Effects of distributed database modeling on evaluation of transaction rollbacks

NASA Technical Reports Server (NTRS)

Mukkamala, Ravi

1991-01-01

Data distribution, degree of data replication, and transaction access patterns are key factors in determining the performance of distributed database systems. In order to simplify the evaluation of performance measures, database designers and researchers tend to make simplistic assumptions about the system. Here, researchers investigate the effect of modeling assumptions on the evaluation of one such measure, the number of transaction rollbacks in a partitioned distributed database system. The researchers developed six probabilistic models and expressions for the number of rollbacks under each of these models. Essentially, the models differ in terms of the available system information. The analytical results obtained are compared to results from simulation. It was concluded that most of the probabilistic models yield overly conservative estimates of the number of rollbacks. The effect of transaction commutativity on system throughput is also grossly undermined when such models are employed.

Work-family balance and academic advancement in medical schools.

PubMed

Fox, Geri; Schwartz, Alan; Hart, Katherine M

2006-01-01

This study examines various options that a faculty member might exercise to achieve work-family balance in academic medicine and their consequences for academic advancement. Three data sets were analyzed: an anonymous web-administered survey of part-time tenure track-eligible University of Illinois College of Medicine (UI-COM) faculty members conducted in 2003; exogenous data regarding the entire UI-COM faculty; and tenure rollback ("stop-the-clock") usage by all tenure track-eligible UI-COM faculty from 1994 to 2003. The data reveal a gender split in career-family balance priorities that affect academic advancement among part-time faculty. Women select part-time status for child care; men choose part-time to moonlight. Similarly, among all faculty members seeking tenure rollbacks, women request rollback for child care; men request rollback for other reasons. Among all faculty members, full-time men were more likely to be on the tenure track than any other group. Needs identified by the part-time faculty survey include improved mentoring in track selection, heightened awareness of options, such as tenure rollback, and provision of equitable benefits and opportunities. Policy changes, such as a prorated tenure track, are needed to support a family-friendly culture with flexibility throughout the career lifespan for both men and women medical faculty.

Lazy checkpoint coordination for bounding rollback propagation

NASA Technical Reports Server (NTRS)

Wang, Yi-Min; Fuchs, W. Kent

1992-01-01

Independent checkpointing allows maximum process autonomy but suffers from potential domino effects. Coordinated checkpointing eliminates the domino effect by sacrificing a certain degree of process autonomy. In this paper, we propose the technique of lazy checkpoint coordination which preserves process autonomy while employing communication-induced checkpoint coordination for bounding rollback propagation. The introduction of the notion of laziness allows a flexible trade-off between the cost for checkpoint coordination and the average rollback distance. Worst-case overhead analysis provides a means for estimating the extra checkpoint overhead. Communication trace-driven simulation for several parallel programs is used to evaluate the benefits of the proposed scheme for real applications.

Space Reclamation for Uncoordinated Checkpointing in Message-Passing Systems. Ph.D. Thesis

NASA Technical Reports Server (NTRS)

Wang, Yi-Min

1993-01-01

Checkpointing and rollback recovery are techniques that can provide efficient recovery from transient process failures. In a message-passing system, the rollback of a message sender may cause the rollback of the corresponding receiver, and the system needs to roll back to a consistent set of checkpoints called recovery line. If the processes are allowed to take uncoordinated checkpoints, the above rollback propagation may result in the domino effect which prevents recovery line progression. Traditionally, only obsolete checkpoints before the global recovery line can be discarded, and the necessary and sufficient condition for identifying all garbage checkpoints has remained an open problem. A necessary and sufficient condition for achieving optimal garbage collection is derived and it is proved that the number of useful checkpoints is bounded by N(N+1)/2, where N is the number of processes. The approach is based on the maximum-sized antichain model of consistent global checkpoints and the technique of recovery line transformation and decomposition. It is also shown that, for systems requiring message logging to record in-transit messages, the same approach can be used to achieve optimal message log reclamation. As a final topic, a unifying framework is described by considering checkpoint coordination and exploiting piecewise determinism as mechanisms for bounding rollback propagation, and the applicability of the optimal garbage collection algorithm to domino-free recovery protocols is demonstrated.

South-American plate advance and forced Andean trench retreat as drivers for transient flat subduction episodes.

PubMed

Schepers, Gerben; van Hinsbergen, Douwe J J; Spakman, Wim; Kosters, Martha E; Boschman, Lydian M; McQuarrie, Nadine

2017-05-16

At two trench segments below the Andes, the Nazca Plate is subducting sub-horizontally over ∼200-300 km, thought to result from a combination of buoyant oceanic-plateau subduction and hydrodynamic mantle-wedge suction. Whether the actual conditions for both processes to work in concert existed is uncertain. Here we infer from a tectonic reconstruction of the Andes constructed in a mantle reference frame that the Nazca slab has retreated at ∼2 cm per year since ∼50 Ma. In the flat slab portions, no rollback has occurred since their formation at ∼12 Ma, generating 'horse-shoe' slab geometries. We propose that, in concert with other drivers, an overpressured sub-slab mantle supporting the weight of the slab in an advancing upper plate-motion setting can locally impede rollback and maintain flat slabs until slab tearing releases the overpressure. Tear subduction re-establishes a continuous slab and allows the process to recur, providing a mechanism for the transient character of flat slabs.

Evaluating the Functionality and Usability of Two Novel Wheelchair Anti-Rollback Devices for Ramp Ascent in Manual Wheelchair Users With Spinal Cord Injury.

PubMed

Deems-Dluhy, Susan L; Jayaraman, Chandrasekaran; Green, Steve; Albert, Mark V; Jayaraman, Arun

2017-05-01

Difficulty ascending ramps and inclines with a manual wheelchair adversely affects the everyday mobility and overall quality of life of manual wheelchair users. Currently, various anti-rollback devices are available to assist manual wheelchair users to ascend ramps and inclines. However, these devices have 2 main shortcomings: restriction to backward motion limiting recovery from an overturning wheelchair, which is a safety concern; and difficulty in engaging/disengaging the device while on the ramp. To evaluate the functionality and usability of 2 novel wheelchair anti-rollback devices developed to address these shortcomings (prototypes "Wheel" and "Brake"). Cross-sectional. Rehabilitation research facility. Twelve adult participants with chronic spinal cord injury. Participants completed training and tested with both the wheelchair anti-rollback devices on a 7.3-m-long ramp. Number of stops, perceived physical exertion, pain, and ease of use of these devices as participants maneuvered their wheelchairs up a 7.3-m ramp were assessed. Participants also evaluated their satisfaction with the usability of both the devices using the Quebec User Evaluation of Satisfaction With Assistive Technology (QUEST 2.0). Both prototypes evaluated overcame the limitations of the existing anti-rollback devices. Nonparametric statistical tests showed that participants rated both prototypes similarly for the overall functional and usability aspects. However, the participants' satisfactory rating were higher for the prototype "Brake" than for the prototype "Wheel" based on a functional aspect (ie, engaging/disengaging easiness), and higher for Wheel than for Brake, based on a usability aspect (prototype size). The qualitative and quantitative outcomes of this investigation, based on the usability and functional evaluations, provided useful information for the improvement in the design of both anti-rollback devices, which may allow manual wheelchair users to manage ramp ascent more safely and easily. Further evaluations with a different SCI population is recommended. IV. Copyright © 2017 American Academy of Physical Medicine and Rehabilitation. Published by Elsevier Inc. All rights reserved.

Multiple Alternatives Modeling in Determining Fiscal Roll-Backs during Educational Funding Crises. Interim Draft. Paper and Report Series No. 70.

ERIC Educational Resources Information Center

Wholeben, Brent E.; Sullivan, John M.

This report provides an extensive discussion of the use of criterion referenced, mathematical modeling procedures to determine which budget reductions minimize reduction in the quality of educational programs. Part I, "Evaluation of Potential Budgeting Roll-backs under Educational Fiscal Crisis," explains the basic design of multiple…

Using Rollback Avoidance to Mitigate Failures in Next-Generation Extreme-Scale Systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Levy, Scott N.

2016-05-01

High-performance computing (HPC) systems enable scientists to numerically model complex phenomena in many important physical systems. The next major milestone in the development of HPC systems is the construction of the rst supercomputer capable executing more than an exa op, 10 18 oating point operations per second. On systems of this scale, failures will occur much more frequently than on current systems. As a result, resilience is a key obstacle to building next-generation extremescale systems. Coordinated checkpointing is currently the most widely-used mechanism for handling failures on HPC systems. Although coordinated checkpointing remains e ective on current systems, increasing themore » scale of today's systems to build next-generation systems will increase the cost of fault tolerance as more and more time is taken away from the application to protect against or recover from failure. Rollback avoidance techniques seek to mitigate the cost of checkpoint/restart by allowing an application to continue its execution rather than rolling back to an earlier checkpoint when failures occur. These techniqes include failure prediction and preventive migration, replicated computation, fault-tolerant algorithms, and softwarebased memory fault correction. In this thesis, we examine how rollback avoidance techniques can be used to address failures on extreme-scale systems. Using a combination of analytic modeling and simulation, we evaluate the potential impact of rollback avoidance on these systems. We then present a novel rollback avoidance technique that exploits similarities in application memory. Finally, we examine the feasibility of using this technique to protect against memory faults in kernel memory.« less

Design and evaluation of a fault-tolerant multiprocessor using hardware recovery blocks

NASA Technical Reports Server (NTRS)

Lee, Y. H.; Shin, K. G.

1982-01-01

A fault-tolerant multiprocessor with a rollback recovery mechanism is discussed. The rollback mechanism is based on the hardware recovery block which is a hardware equivalent to the software recovery block. The hardware recovery block is constructed by consecutive state-save operations and several state-save units in every processor and memory module. When a fault is detected, the multiprocessor reconfigures itself to replace the faulty component and then the process originally assigned to the faulty component retreats to one of the previously saved states in order to resume fault-free execution. A mathematical model is proposed to calculate both the coverage of multi-step rollback recovery and the risk of restart. A performance evaluation in terms of task execution time is also presented.

Specification and Analysis of Parallel Machine Architecture

DTIC Science & Technology

1990-03-17

Parallel Machine Architeture C.V. Ramamoorthy Computer Science Division Dept. of Electrical Engineering and Computer Science University of California...capacity. (4) Adaptive: The overhead in resolution of deadlocks, etc. should be in proportion to their frequency. (5) Avoid rollbacks: Rollbacks can be...snapshots of system state graphically at a rate proportional to simulation time. Some of the examples are as follow: (1) When the simulation clock of

Implementing forward recovery using checkpointing in distributed systems

NASA Technical Reports Server (NTRS)

Long, Junsheng; Fuchs, W. K.; Abraham, Jacob A.

1991-01-01

The paper describes the implementation of a forward recovery scheme using checkpoints and replicated tasks. The implementation is based on the concept of lookahead execution and rollback validation. In the experiment, two tasks are selected for the normal execution and one for rollback validation. It is shown that the recovery strategy has nearly error-free execution time and an average redundancy lower than TMR.

Checkpoint-based forward recovery using lookahead execution and rollback validation in parallel and distributed systems. Ph.D. Thesis, 1992

NASA Technical Reports Server (NTRS)

Long, Junsheng

1994-01-01

This thesis studies a forward recovery strategy using checkpointing and optimistic execution in parallel and distributed systems. The approach uses replicated tasks executing on different processors for forwared recovery and checkpoint comparison for error detection. To reduce overall redundancy, this approach employs a lower static redundancy in the common error-free situation to detect error than the standard N Module Redundancy scheme (NMR) does to mask off errors. For the rare occurrence of an error, this approach uses some extra redundancy for recovery. To reduce the run-time recovery overhead, look-ahead processes are used to advance computation speculatively and a rollback process is used to produce a diagnosis for correct look-ahead processes without rollback of the whole system. Both analytical and experimental evaluation have shown that this strategy can provide a nearly error-free execution time even under faults with a lower average redundancy than NMR.

Gondwana breakup via double-saloon-door rifting and seafloor spreading in a backarc basin during subduction rollback

NASA Astrophysics Data System (ADS)

Martin, A. K.

2007-12-01

A model has been developed where two arc-parallel rifts propagate in opposite directions from an initial central location during backarc seafloor spreading and subduction rollback. The resultant geometry causes pairs of terranes to simultaneously rotate clockwise and counterclockwise like the motion of double-saloon-doors about their hinges. As movement proceeds and the two terranes rotate, a gap begins to extend between them, where a third rift initiates and propagates in the opposite direction to subduction rollback. Observations from the Oligocene to Recent Western Mediterranean, the Miocene to Recent Carpathians, the Miocene to Recent Aegean and the Oligocene to Recent Caribbean point to a two-stage process. Initially, pairs of terranes comprising a pre-existing retro-arc fold thrust belt and magmatic arc rotate about poles and accrete to adjacent continents. Terrane docking reduces the width of the subduction zone, leading to a second phase during which subduction to strike-slip transitions initiate. The clockwise rotated terrane is caught up in a dextral strike-slip zone, whereas the counterclockwise rotated terrane is entrained in a sinistral strike-slip fault system. The likely driving force is a pair of rotational torques caused by slab sinking and rollback of a curved subduction hingeline. By analogy with the above model, a revised five-stage Early Jurassic to Early Cretaceous Gondwana dispersal model is proposed in which three plates always separate about a single triple rift or triple junction in the Weddell Sea area. Seven features are considered diagnostic of double-saloon-door rifting and seafloor spreading: earliest movement involves clockwise and counterclockwise rotations of the Falkland Islands Block and the Ellsworth Whitmore Terrane respectively; terranes comprise areas of a pre-existing retro-arc fold thrust belt (the Permo-Triassic Gondwanide Orogeny) attached to an accretionary wedge/magmatic arc; the Falklands Islands Block is initially attached to Southern Patagonia/West Antarctic Peninsula, while the Ellsworth Whitmore Terrane is combined with the Thurston Island Block; paleogeographies demonstrate rifting and extension in a backarc environment relative to a Pacific margin subduction zone/accretionary wedge where simultaneous crustal shortening occurs; a ridge jump towards the subduction zone from east of the Falkland Islands to the Rocas Verdes Basin evinces subduction rollback; this ridge jump combined with backarc extension isolated an area of thicker continental crust — The Falkland Islands Block; well-documented EW oriented seafloor spreading anomalies in the Weddell Sea are perpendicular to the subduction zone and propagate in the opposite direction to rollback; the dextral strike-slip Gastre and sub-parallel faults form one boundary of the Gondwana subduction rollback, whereas the other boundary may be formed by inferred sinistral strike-slip motion between a combined Thurston Island/Ellsworth Whitmore Terrane and Marie Byrd Land/East Antarctica.

Design and scheduling for periodic concurrent error detection and recovery in processor arrays

NASA Technical Reports Server (NTRS)

Wang, Yi-Min; Chung, Pi-Yu; Fuchs, W. Kent

1992-01-01

Periodic application of time-redundant error checking provides the trade-off between error detection latency and performance degradation. The goal is to achieve high error coverage while satisfying performance requirements. We derive the optimal scheduling of checking patterns in order to uniformly distribute the available checking capability and maximize the error coverage. Synchronous buffering designs using data forwarding and dynamic reconfiguration are described. Efficient single-cycle diagnosis is implemented by error pattern analysis and direct-mapped recovery cache. A rollback recovery scheme using start-up control for local recovery is also presented.

Rollback of an intraoceanic subduction system and termination against a continental margin

NASA Astrophysics Data System (ADS)

Campbell, S. M.; Simmons, N. A.; Moucha, R.

2017-12-01

The Southeast Indian Slab (SEIS) seismic anomaly has been suggested to represent a Tethyan intraoceanic subduction system which operated during the Jurassic until its termination at or near the margin of East Gondwana (Simmons et al., 2015). As plate reconstructions suggest the downgoing plate remained coupled to the continental margin, this long-lived system likely experienced a significant amount of slab rollback and trench migration (up to 6000 km). Using a 2D thermomechanical numerical code that includes the effects of phase transitions, we test this interpretation by modeling the long-term subduction, transition zone stagnation, and rollback of an intraoceanic subduction system in which the downgoing plate remains coupled to a continental margin. In addition, we also investigate the termination style of such a system, with a particular focus on the potential for some continental subduction beneath an overriding oceanic plate. This work performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344. LLNL-ABS-735738

Total knee replacement with natural rollback.

PubMed

Wachowski, Martin Michael; Walde, Tim Alexander; Balcarek, Peter; Schüttrumpf, Jan Philipp; Frosch, Stephan; Stauffenberg, Caspar; Frosch, Karl-Heinz; Fiedler, Christoph; Fanghänel, Jochen; Kubein-Meesenburg, Dietmar; Nägerl, Hans

2012-03-20

A novel class of total knee replacement (AEQUOS G1) is introduced which features a unique design of the articular surfaces. Based on the anatomy of the human knee and differing from all other prostheses, the lateral tibial "plateau" is convexly curved and the lateral femoral condyle is posteriorly shifted in relation to the medial femoral condyle. Under compressive forces the configuration of the articular surfaces of human knees constrains the relative motion of femur and tibia in flexion/extension. This constrained motion is equivalent to that of a four-bar linkage, the virtual 4 pivots of which are given by the centres of curvature of the articulating surfaces. The dimensions of the four-bar linkage were optimized to the effect that constrained motion of the total knee replacement (TKR) follows the flexional motion of the human knee in close approximation, particularly during gait. In pilot studies lateral X-ray pictures have demonstrated that AEQUOS G1 can feature the natural rollback in vivo. Rollback relieves the load of the patello-femoral joint and minimizes retropatellar pressure. This mechanism should reduce the prevalence of anterior knee pain. The articulating surfaces roll predominantly in the stance phase. Consequently sliding friction is replaced by the lesser rolling friction under load. Producing rollback should minimize material wear due to friction and maximize the lifetime of the prosthesis. To definitely confirm these theses one has to wait for the long term results. Copyright © 2011 Elsevier GmbH. All rights reserved.

Health-Related Benefits of Attaining the 8-Hr Ozone Standard

PubMed Central

Hubbell, Bryan J.; Hallberg, Aaron; McCubbin, Donald R.; Post, Ellen

2005-01-01

During the 2000–2002 time period, between 36 and 56% of ozone monitors each year in the United States failed to meet the current ozone standard of 80 ppb for the fourth highest maximum 8-hr ozone concentration. We estimated the health benefits of attaining the ozone standard at these monitors using the U.S. Environmental Protection Agency’s Environmental Benefits Mapping and Analysis Program. We used health impact functions based on published epidemiologic studies, and valuation functions derived from the economics literature. The estimated health benefits for 2000 and 2001 are similar in magnitude, whereas the results for 2002 are roughly twice that of each of the prior 2 years. The simple average of health impacts across the 3 years includes reductions of 800 premature deaths, 4,500 hospital and emergency department admissions, 900,000 school absences, and > 1 million minor restricted activity days. The simple average of benefits (including premature mortality) across the 3 years is $5.7 billion [90% confidence interval (CI), 0.6–15.0] for the quadratic rollback simulation method and $4.9 billion (90% CI, 0.5–14.0) for the proportional rollback simulation method. Results are sensitive to the form of the standard and to assumptions about background ozone levels. If the form of the standard is based on the first highest maximum 8-hr concentration, impacts are increased by a factor of 2–3. Increasing the assumed hourly background from zero to 40 ppb reduced impacts by 30 and 60% for the proportional and quadratic attainment simulation methods, respectively. PMID:15626651

Subduction hinge migration: The backwards component of plate tectonics

NASA Astrophysics Data System (ADS)

Stegman, D.; Freeman, J.; Schellart, W.; Moresi, L.; May, D.

2005-12-01

There are approximately 50 distinct segments of subduction zones in the world, of which 40% have oceanic lithosphere subducting under oceanic lithosphere. All of these ocean-ocean systems are currently experiencing hinge-rollback, with the exception of 2 (Mariana and Kermadec). In hinge-rollback, the surface trace of the suduction zone (trench) is moving in the opposite direction as the plate is moving (i.e. backwards). Coincidentally, the fastest moving plate boundary in the world is actually the Tonga trench at an estimated 17 cm/yr (backwards). Although this quite important process was recognized soon after the birth of plate tectonic theory (Elsasser, 1971), it has received only a limited amount of attention (Garfunkel, 1986; Kincaid and Olson, 1987) until recently. Laboratory models have shown that having a three dimensional experiment is essential in order to build a correct understanding of subduction. We have developed a numerical model with the neccessary 3-D geometry capable of investigating some fundamental questions of plate tectonics: How does hinge-rollback feedback into surface tectonics and mantle flow? What can we learn about the forces that drive plate tectonics by studying hinge-rollback? We will present a quantatitive analysis of the effect of the lateral width of subduction zones, the key aspect to understanding the nature of hinge-rollback. Additionally, particular emphasis has been put on gaining intuition through the use of movies (a 3-D rendering of the numerical models), illustrating the time evolution of slab interactions with the lower mantle as seen in such fields as velocity magnitude, strain rate, viscosity, as well as the toroidal and poloidal components of induced flow. This investigation is well-suited to developing direct comparisons with geological and geophysical observations such as geodetically determined hinge retreat rates, geochemical and petrological observations of arc volcanics and back-arc ridge basalts, timing and distribution of metamorphic core complexes in backarc basins under extension, paleostress observables such surface movements and block rotations, observations of seismic anistropy determined by shear wave splitting, and the emerging studies of regional tomographic models of seismic anistropy.

STS-79 Atlantis rolls back to the VAB (flag in foreground)

NASA Technical Reports Server (NTRS)

1996-01-01

The Space Shuttle Atlantis passes by the Turn Basin and the American flag at the Press Site, in foreground, en route to the Vehicle Assembly Building, where it will be sheltered from the threat of Hurricane Fran. Atlantis is rolling back from Launch Pad 39A, where it was undergoing preparations for Mission STS-79. This marks the second rollback for Atlantis since July because of hurricane threats. The threat of Hurricane Bertha forced the rollback of Atlantis in July. Atlantis currently is scheduled for launch on the fourth Shuttle-Mir docking mission around mid- September.

STS-79 Atlantis rolls back to the VAB at sunrise

NASA Technical Reports Server (NTRS)

1996-01-01

As the sun begins to rise in the early-morning sky, the Space Shuttle Atlantis slowly travels on the Crawlerway toward the Vehicle Assembly Building (VAB) after its departure from Launch Pad 39A. This marks the second rollback for Atlantis since July because of hurricane threats. Atlantis, which is targeted for liftoff later this month on the STS-79 Shuttle mission, is returning to the VAB because of the threat from Hurricane Fran. The threat of Hurricane Bertha forced the rollback of Atlantis in July. Atlantis currently is scheduled for launch on the fourth Shuttle-Mir docking mission around mid-September.

STS-97 Endeavour after RSS rollback

NASA Technical Reports Server (NTRS)

2000-01-01

After rollback of the Rotating Service Structure (at left), Space Shuttle Endeavour stands ready for launch targeted for 10:06 p.m. EST tonight on mission STS-97 to the International Space Station. The orbiter carries the P6 Integrated Truss Segment containing solar arrays that will be temporarily installed to the Unity connecting module by the Z1 truss, recently delivered to and installed on the Station on mission STS-92. The two solar arrays are each more than 100 feet long. They will capture energy from the sun and convert it to power for the Station. Two spacewalks will be required to install the solar array connections.

Pull-Apart vs. Subduction Rollback Mechanisms For The Cenozoic Formation Of Bohai Basin, Eastern China

NASA Astrophysics Data System (ADS)

Castellanos, H. A.; Mann, P.

2005-12-01

The Bohai basin of eastern China covers an area of about 200,000 km2 and forms one of a family of basins that record Cenozoic extension along the eastern margin of Asia from Viet Nam to northeastern Russia. Two very different deformational mechanisms have been proposed for the Cenozoic formation of the Bohai basin. The first model proposes a two-stage extension model consisting of Paleogene rifting in a WNW-ESE direction followed by Neogene thermal subsidence that controlled overlying and less deformed sag basins above the rifted section (Ye et al., 1985). The mechanism for two-stage rifting is generally attributed to rollback of the subducted Pacific plate beneath the Asian continent, lithospheric extension of the overriding continental plate, and thermally-driven, regional subsidence. A second model invokes a more localized Cenozoic pull-apart basin formed at a right-step in a right-lateral shear system parallel to the Asian continental margin (Allen et al., 1997). Earthquakes and GPS data indicate that right-lateral strike-slip faulting continues to the present-day in a pattern consistent with the regional-scale "lazy-Z" map pattern of the Cenozoic Bohai depocenter. Allen et al. (1997) propose the subsurface of the large pull-apart structure contains diffuse, sub-parallel strike-slip faults offset by smaller-scale, intrabasinal stepovers. In order to better distinguish the timing and mechanism for the formation of the Bohai basin, we have interpreted 1400 km of offshore 2D seismic data, a 3D seismic volume, and integrated lithostratigraphic data from 6 wells that are tied to these reflection data. Three major units were identified and mapped on a basin-wide scale: basement, a syn-rift unit, and a post-rift sag unit. Thickening trends and ages indicate the syn-rift phase occurred from late Paleocene to late Oligocene. Basin opening occurred on a series of half-grabens trending NNE-SSW. Rifting ended during the late Oligocene when a regional uplift and erosional event affected the basin. The Miocene to recent was marked by the formation of sag basins deformed by widely-spaced strike-slip faults. These active strike-slip faults are commonly localized on earlier normal faults. Given these observations a three stage basin history is proposed: 1) Eocene-late Oligocene basin opening across a diffuse set of half-grabens; the pattern of rifts supports a regional extension possibly related to subduction rollback of the Pacific plate; 2) a late Oligocene uplift and erosional event of unknown origin; and 3) late Oligocene to recent strike-slip faulting; the regional-scale "lazy-Z" map pattern of Bohai depocenter indicates the importance of right-stepping pull-apart control on the younger sag section.

Longitudinal Strain in the Forearc of a Rollback-Subduction System Forced to Change Length: Structural evolution of the Crotone Basin in NE Calabria, Southern Italy

NASA Astrophysics Data System (ADS)

Reitz, M. A.; Seeber, L.

2009-12-01

Calabria is a continental fragment incorporated into a forearc overriding the WNW directed subduction system. This system rolled back toward ESE across the central Mediterranean during the Neogene to form the Tyrrhenian Basin. Riding above the megathrust, forearcs seek a dynamic equilibrium between boundary stresses (drag below and lateral containments) with body stress (gravity acting on the shape of the forearc). Changes in boundary conditions are balanced by changes in the shape. The internal deformation history of the forearc, therefore, is expected to reflect changes in subduction tectonics during the evolution of the arc. We analyzed the structure of the Crotone Basin, located in northeastern Calabria, which is located in the exposed part of the forearc closest to the deformation front and to the Apennines. The main purpose was to compare the successive phases of deformation in the basin to the known evolution of the arc. We found four distinct events from the late Tortonian to the present. A widespread unconformity correlated with the onset of rollback marks a regional foundering with multidirectional normal growth faults. Following this pervasive and deeply rooted extension, the Crotone Basin experiences a period of parallel and distal sedimentation (Ponda clay). These sediments mark a relative long period (~5ma) of remarkable tectonic quiescence, even though subduction-rollback is moving the arc rapidly (3-5cm/yr) to the ESE. In addition, the forearc is shortening by progressive collision with Apulia (the Apennines) and Africa (the Maghrebides) during this time, but our study area is still far from the oblique collisions occurring at the ends of the forearc. The Messinian Salinity Crisis (5.3-6Ma) causes major instabilities in the accretion by loading it with evaporite deposits first and then removing the water load. Landward (westward) thrusting of the accretionary complex correlates with the Messinian in the Crotone basin and elsewhere along eastern Calabria. A characteristic fluvial conglomerate that locally caps the evaporite sequence records this thrusting by a systematic fracturing of the cobbles. After a well-known mid-Pliocene basin-forming extensional event, we find evidence of a basin-wide contractional event affecting the entire Neogene sequence up to the mid-to-late Pliocene. The data show a north-south compression with vergence to the north. This arc-longitudinal shortening may correlate with mid-Pliocene N-S shortening reported in the southern Apennines. Finally, many of these shortening structures are cut or reactivated by a recent (mid-Pleistocene?) faults, that accommodate extension also directed N-S to NW-SE. Our data show a shift from radial to longitudinal tectonics in the Pliocene as the Crotone basin nears the oblique collision with Apulia. Longitudinal forearc shortening may lead to extension in the Pleistocene, as the forearc squeezes through the narrow between Africa (Sicily) and Apulia, and begins lengthening as rollback consumes progressively wider Ionian lithosphere.

The dynamics of plate tectonics and mantle flow: from local to global scales.

PubMed

Stadler, Georg; Gurnis, Michael; Burstedde, Carsten; Wilcox, Lucas C; Alisic, Laura; Ghattas, Omar

2010-08-27

Plate tectonics is regulated by driving and resisting forces concentrated at plate boundaries, but observationally constrained high-resolution models of global mantle flow remain a computational challenge. We capitalized on advances in adaptive mesh refinement algorithms on parallel computers to simulate global mantle flow by incorporating plate motions, with individual plate margins resolved down to a scale of 1 kilometer. Back-arc extension and slab rollback are emergent consequences of slab descent in the upper mantle. Cold thermal anomalies within the lower mantle couple into oceanic plates through narrow high-viscosity slabs, altering the velocity of oceanic plates. Viscous dissipation within the bending lithosphere at trenches amounts to approximately 5 to 20% of the total dissipation through the entire lithosphere and mantle.

Steady rotation of the Cascade arc

USGS Publications Warehouse

Wells, Ray E.; McCaffrey, Robert

2013-01-01

Displacement of the Miocene Cascade volcanic arc (northwestern North America) from the active arc is in the same sense and at nearly the same rate as the present clockwise block motions calculated from GPS velocities in a North American reference frame. Migration of the ancestral arc over the past 16 m.y. can be explained by clockwise rotation of upper-plate blocks at 1.0°/m.y. over a linear melting source moving westward 1–4.5 km/m.y. due to slab rollback. Block motion and slab rollback are in opposite directions in the northern arc, but both are westerly in the southern extensional arc, where rollback may be enhanced by proximity to the edge of the Juan de Fuca slab. Similarities between post–16 Ma arc migration, paleomagnetic rotation, and modern GPS block motions indicate that the secular block motions from decadal GPS can be used to calculate long-term strain rates and earthquake hazards. Northwest-directed Basin and Range extension of 140 km is predicted behind the southern arc since 16 Ma, and 70 km of shortening is predicted in the northern arc. The GPS rotation poles overlie a high-velocity slab of the Siletzia terrane dangling into the mantle beneath Idaho (United States), which may provide an anchor for the rotations.

Visual Data-Analytics of Large-Scale Parallel Discrete-Event Simulations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ross, Caitlin; Carothers, Christopher D.; Mubarak, Misbah

Parallel discrete-event simulation (PDES) is an important tool in the codesign of extreme-scale systems because PDES provides a cost-effective way to evaluate designs of highperformance computing systems. Optimistic synchronization algorithms for PDES, such as Time Warp, allow events to be processed without global synchronization among the processing elements. A rollback mechanism is provided when events are processed out of timestamp order. Although optimistic synchronization protocols enable the scalability of large-scale PDES, the performance of the simulations must be tuned to reduce the number of rollbacks and provide an improved simulation runtime. To enable efficient large-scale optimistic simulations, one has tomore » gain insight into the factors that affect the rollback behavior and simulation performance. We developed a tool for ROSS model developers that gives them detailed metrics on the performance of their large-scale optimistic simulations at varying levels of simulation granularity. Model developers can use this information for parameter tuning of optimistic simulations in order to achieve better runtime and fewer rollbacks. In this work, we instrument the ROSS optimistic PDES framework to gather detailed statistics about the simulation engine. We have also developed an interactive visualization interface that uses the data collected by the ROSS instrumentation to understand the underlying behavior of the simulation engine. The interface connects real time to virtual time in the simulation and provides the ability to view simulation data at different granularities. We demonstrate the usefulness of our framework by performing a visual analysis of the dragonfly network topology model provided by the CODES simulation framework built on top of ROSS. The instrumentation needs to minimize overhead in order to accurately collect data about the simulation performance. To ensure that the instrumentation does not introduce unnecessary overhead, we perform a scaling study that compares instrumented ROSS simulations with their noninstrumented counterparts in order to determine the amount of perturbation when running at different simulation scales.« less

Slab Roll-Back and Trench Retreat As Controlling Factor for Island-Arc Related Basin Evolution: A Case Study from Southern Central America

NASA Astrophysics Data System (ADS)

Brandes, C.; Winsemann, J.

2014-12-01

Slab roll-back and trench retreat are important factors for basin subsidence, magma generation and volcanism in arc-trench systems. From the sedimentary and tectonic record of the Central American island-arc it is evident that repeated slab roll-back and trench retreats occurred since the Late Cretaceous. These trench retreats were most probably related to the subduction of oceanic plateaus and seamounts. Evidence for trench retreats is given by pulses of uplift in the outer-arc area, followed by subsidence in both the fore-arc and back-arc basins. The first slab roll-back probably occurred during the Early Paleocene indicated by the collapse of carbonate platforms, and the re-deposition of large carbonate blocks into deep-water turbidites. At this time the island-arc was transformed from an incipient non-extensional stage into an extensional stage. A new pulse of uplift or decreased subsidence, respectively during the Late Eocene is attributed to subduction of rough crust, a subsequent slab detachment and the establishment of a new subduction zone further westward. Strong uplift especially affected the outer arc of the North Costa Rican arc segment. In the Sandino Fore-arc basin very coarse-grained deep-water channel-levee complexes were deposited. These deposits contain large well-rounded andesitic boulders and are rich in reworked shallow-water carbonates pointing to uplift of the inner fore-arc. Evidence for the subsequent trench retreat is given by an increased subsidence during the early Oligocene in the Sandino Fore-arc Basin and the collapse of the Barra Honda platform in North Costa Rica. Another trench retreat might have occurred in Miocene times. A phase of higher subsidence from 18 to 13 Ma is documented in the geohistory curve of the North Limon Back-arc Basin. After a short pulse of uplift the subsidence increased to approx. 300 m/myr.

Multithreaded Stochastic PDES for Reactions and Diffusions in Neurons.

PubMed

Lin, Zhongwei; Tropper, Carl; Mcdougal, Robert A; Patoary, Mohammand Nazrul Ishlam; Lytton, William W; Yao, Yiping; Hines, Michael L

2017-07-01

Cells exhibit stochastic behavior when the number of molecules is small. Hence a stochastic reaction-diffusion simulator capable of working at scale can provide a more accurate view of molecular dynamics within the cell. This paper describes a parallel discrete event simulator, Neuron Time Warp-Multi Thread (NTW-MT), developed for the simulation of reaction diffusion models of neurons. To the best of our knowledge, this is the first parallel discrete event simulator oriented towards stochastic simulation of chemical reactions in a neuron. The simulator was developed as part of the NEURON project. NTW-MT is optimistic and thread-based, which attempts to capitalize on multi-core architectures used in high performance machines. It makes use of a multi-level queue for the pending event set and a single roll-back message in place of individual anti-messages to disperse contention and decrease the overhead of processing rollbacks. Global Virtual Time is computed asynchronously both within and among processes to get rid of the overhead for synchronizing threads. Memory usage is managed in order to avoid locking and unlocking when allocating and de-allocating memory and to maximize cache locality. We verified our simulator on a calcium buffer model. We examined its performance on a calcium wave model, comparing it to the performance of a process based optimistic simulator and a threaded simulator which uses a single priority queue for each thread. Our multi-threaded simulator is shown to achieve superior performance to these simulators. Finally, we demonstrated the scalability of our simulator on a larger CICR model and a more detailed CICR model.

Time Warp Operating System (TWOS)

NASA Technical Reports Server (NTRS)

Bellenot, Steven F.

1993-01-01

Designed to support parallel discrete-event simulation, TWOS is complete implementation of Time Warp mechanism - distributed protocol for virtual time synchronization based on process rollback and message annihilation.

Exploring the effect of anisotropy on body-wave tomography models: Rollback and subduction of the Alboran slab

NASA Astrophysics Data System (ADS)

Lee, H.; Bezada, M.

2017-12-01

Teleseismic P-wave tomography models often show low-velocity anomalies behind subducted slabs (i.e. opposite the direction of subduction). One such anomaly, behind the Alboran slab in the westernmost Mediterranean, requires partial melt in the mantle if taken at face-value. However, mantle anisotropy can cause low-velocity anomalies in tomographic models that assume isotropy. In fact, results from SKS splitting suggest rollback-induced anisotropy within the low-velocity region, and we investigate if this anisotropy can explain the sub-slab anomaly. We include anisotropy as an a priori constraint on the inversion and test different magnitudes, azimuths, and dips within the low-velocity region. We find that a range of anisotropic models can fit the travel time data as well as the isotropic models while significantly reducing or eliminating the low-velocity anomaly behind the slab. We conclude that this alternative interpretation (delays are caused by anisotropic structure) is as consistent with the travel time data as an isotropic low-velocity anomaly, and more consistent with SKS splitting observations and the known history of rollback. In addition, we find that models that include anisotropy with steeply dipping fast axes, meant to simulate the effect of downgoing entrained mantle, provide a poorer fit to the travel times than all the other models. This suggests that the slab may no longer be actively subducting.

Performance and evaluation of real-time multicomputer control systems

NASA Technical Reports Server (NTRS)

Shin, K. G.

1983-01-01

New performance measures, detailed examples, modeling of error detection process, performance evaluation of rollback recovery methods, experiments on FTMP, and optimal size of an NMR cluster are discussed.

Laboratory experiments on subduction-induced circulation in the wedge and the evolution of mantle diapirs

NASA Astrophysics Data System (ADS)

Sylvia, R. T.; Kincaid, C. R.; Behn, M. D.; Zhang, N.

2014-12-01

Circulation in subduction zones involves large-scale, forced-convection by the motion of the down-going slab and small scale, buoyant diapirs of hydrated mantle or subducted sediments. Models of subduction-diapir interaction often neglect large-scale flow patterns induced by rollback, back-arc extension and slab morphology. We present results from laboratory experiments relating these parameters to styles of 4-D wedge circulation and diapir ascent. A glucose fluid is used to represent the mantle. Subducting lithosphere is modeled with continuous rubber belts moving with prescribed velocities, capable of reproducing a large range in downdip relative rollback plate rates. Differential steepening of distinct plate segments simulates the evolution of slab gaps. Back-arc extension is produced using Mylar sheeting in contact with fluid beneath the overriding plate that moves relative to the slab rollback rate. Diapirs are introduced at the slab-wedge interface in two modes: 1) distributions of low density rigid spheres and 2) injection of low viscosity, low density fluid to the base of the wedge. Results from 30 experiments with imposed along-trench (y) distributions of buoyancy, show near-vertical ascent paths only in cases with simple downdip subduction and ratios (W*) of diapir rise velocity to downdip plate rate of W*>1. For W* = 0.2-1, diapir ascent paths are complex, with large (400 km) lateral offsets between source and surfacing locations. Rollback and back-arc extension enhance these offsets, occasionally aligning diapirs from different along-trench locations into trench-normal, age-progressive linear chains beneath the overriding plate. Diapirs from different y-locations may surface beneath the same volcanic center, despite following ascent paths of very different lengths and transit times. In cases with slab gaps, diapirs from the outside edge of the steep plate move 1000 km parallel to the trench before surfacing above the shallow dipping plate. "Dead zones" resulting from lateral and vertical shear in the wedge above the slab gap, produce slow transit times. These 4-D ascent pathways are being incorporated into numerical models on the thermal and melting evolution of diapirs. Models show subduction-induced circulation significantly alters diapir ascent beneath arcs.

Kinematic comparison between mobile-bearing and fixed-bearing inserts in NexGen legacy posterior stabilized flex total knee arthroplasty.

PubMed

Shi, Kenrin; Hayashida, Kenji; Umeda, Naoya; Yamamoto, Kengo; Kawai, Hideo

2008-02-01

Femoral component rollback and tibial rotation were evaluated using lateral radiographs taken during passive knee flexion under fluoroscopy in NexGen Legacy Posterior Stabilized Flex (Zimmer, Warsaw, Ind) total knee arthroplasties (TKAs; 30 with mobile insert and 26 with fixed insert). Measured maximal flexion angle demonstrated no significant differences. Femoral component rollback was observed predominantly in TKAs with fixed insert in more than 45 degrees flexion and correlated with maximal flexion angle in each group. Tibial internal rotation was more significant in TKAs with mobile insert in maximal flexion. However, tibial internal rotation from 90 degrees to maximal flexion, which demonstrated correlation with maximal flexion angle in each group, did not show significant difference. The kinematic differences between 2 inserts seemed to have little relevance to the maximal flexion angle.

Evidences for recent plume-induced subduction, microplates and localized lateral plate motions on Venus

NASA Astrophysics Data System (ADS)

Davaille, Anne; Smrekar, Suzanne

2017-04-01

Using laboratory experiments and theoretical modeling, we recently showed that plumes could induce roll-back subduction around large coronae. When a hot plume rises under a brittle and visco-elasto-plastic skin/lithosphere, the latter undergoes a flexural deformation which puts it under tension. Radial cracks and rifting of the skin then develop, sometimes using pre-existing weaknesses. Plume material upwells through the cracks (because it is more buoyant) and spreads as a axisymmetric gravity current above the broken denser skin. The latter bends and sinks under the combined force of its own weight and that of the plume gravity current. However, due to the brittle character of the upper part of the experimental lithosphere, it cannot deform viscously to accomodate the sinking motions. Instead, the plate continues to tear, as a sheet of paper would do upon intrusion. Several slabs are therefore produced, associated with trenches localized along partial circles on the plume, and strong roll-back is always observed. Depending on the lithospheric strength, roll-back can continue and triggers a complete resurfacing, or it stops when the plume stops spreading. Two types of microplates are also observed. First, the upwelling plume material creates a set of new plates interior to the trench segments. These plates move rapidly and expand through time, but do not subduct.. In a few cases, we also observe additional microplates exterior to the trenches. This happens when the subducting plate contains preexisting heterogeneities (e.g. fractures) and the subducted slab is massive enough for slab pull to become efficient and induce horizontal plate motions. Scalings derived from the experiments suggest that Venus lithosphere is soft enough to undergo such a regime. And indeed, at least two candidates can be identified on Venus, where plume-induced subduction could have operated. (1) Artemis Coronae is the largest (2300 km across) coronae on Venus and is bounded over 270° of arc by a trench and outer rise, which is proposed to be a subduction zone based on its morphologic similiarity to several terrestrial features. Its interior is cut by a rift and several shear zones. (2) Lada Terra is a 1000 km diameter topographic rise centered near 65°S, 10°E. The 800 km diameter Quetzelpetlatl Corona (QC) defines its western margin. The western edge of QC is defined by a trench and outer rise. As at Artemis, the latter presents also graben and fractures similar to the extensional features seen in the laboratory. The subsurface density variations inferred from modeling the gravity and topography data at both coronae are compatible with the existence of a slab at depth. Moreover, the interior of Artemis looks like the system of growing microplates inside the coronae described in the laboratory. While the second type is probably occuring in the Lada Terra region, where the presence of an extension zone to the north (Kalaipahoa Linea) could mark the edge of a microplate currently subducting at QC. Moreover, evidence for geologically recent volcanism at Quetzelpetlatl suggests that subduction may be currently active on Venus.

In vivo determination of total knee arthroplasty kinematics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Komistek, Richard D; Mahfouz, Mohamed R; Bertin, Kim

2008-01-01

The objective of this study was to determine if consistent posterior femoral rollback of an asymmetrical posterior cruciate retaining (PCR) total knee arthroplasty was mostly influenced by the implant design, surgical technique, or presence of a well-functioning posterior cruciate ligament (PCL). Three-dimensional femorotibial kinematics was determined for 80 subjects implanted by 3 surgeons, and each subject was evaluated under fluoroscopic surveillance during a deep knee bend. All subjects in this present study having an intact PCL had a well-functioning PCR knee and experienced normal kinematic patterns, although less in magnitude than the normal knee. In addition, a surprising finding wasmore » that, on average, subjects without a PCL still achieved posterior femoral rollback from full extension to maximum knee flexion. The findings in this study revealed that implant design did contribute to the normal kinematics demonstrated by subjects having this asymmetrical PCR total knee arthroplasty.« less

Simulation and analysis of support hardware for multiple instruction rollback

NASA Technical Reports Server (NTRS)

Alewine, Neil J.

1992-01-01

Recently, a compiler-assisted approach to multiple instruction retry was developed. In this scheme, a read buffer of size 2N, where N represents the maximum instruction rollback distance, is used to resolve one type of data hazard. This hardware support helps to reduce code growth, compilation time, and some of the performance impacts associated with hazard resolution. The 2N read buffer size requirement of the compiler-assisted approach is worst case, assuring data redundancy for all data required but also providing some unnecessary redundancy. By adding extra bits in the operand field for source 1 and source 2 it becomes possible to design the read buffer to save only those values required, thus reducing the read buffer size requirement. This study measures the effect on performance of a DECstation 3100 running 10 application programs using 6 read buffer configurations at varying read buffer sizes.

Eocene lake basins in Wyoming and Nevada record rollback of the Farallon flat-slab beneath western North America

NASA Astrophysics Data System (ADS)

Smith, M. E.; Cassel, E. J.; Jicha, B. R.; Singer, B. S.; Carroll, A.

2014-12-01

Numerical and conceptual models of flat-slab rollback predict broad initial dynamic subsidence above the slab hinge then uplift and volcanism triggered by the advection of asthenosphere beneath the overriding plate. These predicted surface effects provide a viable but largely untested explanation for lake basin formation in Cordilleran-type orogenies. We argue that the hydrologic closure of both the foreland (early Eocene) and hinterland (late Eocene) of the North American Cordillera were caused by a trenchward-migrating wave of dynamic and thermal topography resulting from progressive removal of the Farallon flat-slab. Two major episodes of hydrologic drainage closure are recorded by Eocene terrestrial strata in the western United States. The first occurred in the retroarc foreland during the early Eocene, and resulted in the deposition of the Green River Fm. The second occurred in the hinterland during the late Eocene and resulted in accumulation of the Elko Fm. In both regions, lake strata overlie fluvial strata and become progressively more evaporative up-section, and are overlain by volcaniclastic strata. Both successions were then truncated by regional unconformities that extend until the Oligocene. We interpret these stratigraphic successions to record trenchward propagation of a regional topographic wave, caused by slab rollback. Migration of the slab-hinge initially caused dynamic subsidence and initiation of lacustrine deposition. Regional surface uplift followed, and was associated with scattered volcanism. Uplift promoted formation of endorheic basins and ultimately the development of regional unconformities. The height of the uplift can be roughly approximated by the preserved thickness of lacustrine and other nonmarine deposits at both locations (0.2-1.0 km). The 40Ar/39Ar and U-Pb geochronology of Green River Fm ash beds indicate that this surface topographic wave migrated trenchward (SW) across the foreland from 53 to 47 Ma at a velocity of ~6 cm/yr. Single crystal sanidine 40Ar/39Ar ages for ash beds within the Elko Fm indicate hydrologic ponding from 43 to 38 Ma. The 4 myr gap between Green River and Elko Fm deposition may represent the time required for the rollback wave to transit the steep eastern slope of the Sevier fold-thrust belt.

Topography of the Overriding Plate During Progressive Subduction: A Dynamic Model to Explain Forearc Subsidence

NASA Astrophysics Data System (ADS)

Chen, Zhihao; Schellart, Wouter P.; Duarte, João. C.; Strak, Vincent

2017-10-01

Overriding plate topography provides constraints on subduction zone geodynamics. We investigate its evolution using fully dynamic laboratory models of subduction with techniques of stereoscopic photogrammetry and particle image velocimetry. Model results show that the topography is characterized by an area of forearc dynamic subsidence, with a magnitude scaling to 1.44-3.97 km in nature, and a local topographic high between the forearc subsided region and the trench. These topographic features rapidly develop during the slab free-sinking phase and gradually decrease during the steady state slab rollback phase. We propose that they result from the variation of the vertical component of the trench suction force along the subduction zone interface, which gradually increases with depth and results from the gradual slab steepening during the initial transient slab sinking phase. The downward mantle flow in the nose of the mantle wedge plays a minor role in driving forearc subsidence.

Resilient distributed control in the presence of misbehaving agents in networked control systems.

PubMed

Zeng, Wente; Chow, Mo-Yuen

2014-11-01

In this paper, we study the problem of reaching a consensus among all the agents in the networked control systems (NCS) in the presence of misbehaving agents. A reputation-based resilient distributed control algorithm is first proposed for the leader-follower consensus network. The proposed algorithm embeds a resilience mechanism that includes four phases (detection, mitigation, identification, and update), into the control process in a distributed manner. At each phase, every agent only uses local and one-hop neighbors' information to identify and isolate the misbehaving agents, and even compensate their effect on the system. We then extend the proposed algorithm to the leaderless consensus network by introducing and adding two recovery schemes (rollback and excitation recovery) into the current framework to guarantee the accurate convergence of the well-behaving agents in NCS. The effectiveness of the proposed method is demonstrated through case studies in multirobot formation control and wireless sensor networks.

Mediolateral femoral component position in TKA significantly alters patella shift and femoral roll-back.

PubMed

Steinbrück, Arnd; Schröder, Christian; Woiczinski, Matthias; Schmidutz, Florian; Müller, Peter E; Jansson, Volkmar; Fottner, Andreas

2017-11-01

Increased retropatellar pressure and altered kinematics are associated with anterior knee pain and unsatisfied patients after total knee arthroplasty (TKA). Since malposition of the implant is believed to contribute to postoperative pain, we performed this in vitro study to evaluate the influence of mediolateral femoral component position on retropatellar pressure as well as tibio-femoral and patella kinematics. For the test, a fixed-bearing TKA was implanted in eight fresh frozen cadaver specimens. To determine the impact of mediolateral (ML) position, three variants of femoral components (3-mm medialization, neutral position and 3-mm lateralization) were produced using rapid prototyping replicas. In a knee rig, a loaded squat from 20° to 120° of flexion was applied. Retropatellar pressure distribution was measured with a pressure-sensitive film. Additionally, an ultrasonic-based three-dimensional motion analysis system was used to register patello- and tibio-femoral kinematics. ML translation of the femoral component by 3 mm did not lead to a significant alteration in retropatellar peak pressure (medial 6.5 ± 2.5 MPa vs. lateral 6.0 ± 2.4 MPa). Following the ML translation of the femoral component, the patella was significantly shifted and tilted in the same directions. Varying the ML femoral component position also led to a significant alteration in femoral roll-back. In day-by-day use, ML position should be chosen with care since there is a significant influence on patella shift and femoral roll-back. Retropatellar pressure is not significantly altered, so there is no clear evidence of an impact on anterior knee pain.

KSC-07pd2923

NASA Image and Video Library

2007-10-22

KENNEDY SPACE CENTER, FLA. -- On Launch Pad 39A on NASA's Kennedy Space Center, space shuttle Discovery is fully revealed after rollback of the rotating service structure, at far left. Next to it is the fixed service structure, or FSS, with the 80-foot-tall lightning mast on top. Extending from the FSS to the golden external tank is the vent hood (known as the "beanie cap") at the end of the gaseous oxygen vent arm. Vapors are created as the liquid oxygen in the external tank boil off. The hood vents the gaseous oxygen vapors away from the space shuttle vehicle. Below it, also extending toward Discovery from the structure, is the orbiter access arm with the White Room at the end. The crew gains access into the orbiter through the White Room. Rollback of the RSS started at 3:34 p.m. EDT and was complete at 4:20 p.m. The RSS provides protected access to the orbiter for changeout and servicing of payloads at the pad. Rollback of the pad's RSS is one of the milestones in preparation for the launch of mission STS-120. Discovery is scheduled for liftoff at 11:38 a.m. EDT on Oct. 23. The mission will be the 23rd assembly flight to the International Space Station and the 34th flight for Discovery. Payload on the mission is the Italian-built U.S. Node 2, called Harmony. The 14-day mission will install Harmony and move the P6 solar arrays to their permanent position and deploy them. Discovery is expected to complete its mission and return home at 4:47 a.m. EST on Nov. 6. Photo credit: NASA/Kim Shiflett

Compression-extension transition of continental crust in a subduction zone: A parametric numerical modeling study with implications on Mesozoic-Cenozoic tectonic evolution of the Cathaysia Block

PubMed Central

Chan, Lung Sang; Gao, Jian-Feng

2017-01-01

The Cathaysia Block is located in southeastern part of South China, which situates in the west Pacific subduction zone. It is thought to have undergone a compression-extension transition of the continental crust during Mesozoic-Cenozoic during the subduction of Pacific Plate beneath Eurasia-Pacific Plate, resulting in extensive magmatism, extensional basins and reactivation of fault systems. Although some mechanisms such as the trench roll-back have been generally proposed for the compression-extension transition, the timing and progress of the transition under a convergence setting remain ambiguous due to lack of suitable geological records and overprinting by later tectonic events. In this study, a numerical thermo-dynamical program was employed to evaluate how variable slab angles, thermal gradients of the lithospheres and convergence velocities would give rise to the change of crustal stress in a convergent subduction zone. Model results show that higher slab dip angle, lower convergence velocity and higher lithospheric thermal gradient facilitate the subduction process. The modeling results reveal the continental crust stress is dominated by horizontal compression during the early stage of the subduction, which could revert to a horizontal extension in the back-arc region, combing with the roll-back of the subducting slab and development of mantle upwelling. The parameters facilitating the subduction process also favor the compression-extension transition in the upper plate of the subduction zone. Such results corroborate the geology of the Cathaysia Block: the initiation of the extensional regime in the Cathaysia Block occurring was probably triggered by roll-back of the slowly subducting slab. PMID:28182640

Long distance transport of eclogite and blueschist during early Pacific Ocean subduction rollback

NASA Astrophysics Data System (ADS)

Tamblyn, Renee; Hand, Martin; Kelsey, David; Phillips, Glen; Anczkiewicz, Robert

2017-04-01

The Tasmanides in eastern Australia represent a period of continental crustal growth on the western margin of the Pacific Ocean associated with slab rollback from the Cambrian until the Triassic. During rollback numerical models predict that subduction products can become trapped in the forearc (Geyra et al., 2002), and can migrate with the trench as it retreats. In a long-lived subduction controlled regime such as the Tasmanides, this should result in an accumulation of subduction products with protracted geochronological and metamorphic histories. U-Pb, Lu-Hf, Sm-Nd and Ar-Ar geochronology and phase equilibria modelling of lawsonite-eclogite and garnet blueschist in the Southern New England Fold Belt in Australia demonstrate that high-P low-T rocks remained within a subduction setting for c. 40 Ma, from c. 500 to 460 Ma. High-P metamorphic rocks initially formed close to the Australian cratonic margin during the late Cambrian, and were subsequently transported over 1500 Ma oceanward, during which time subducted material continued to accumulate, resulting in the development of complex mélange which records eclogite and blueschist metamorphism and partial exhumation over 40 Ma. The duration of refrigerated metamorphism approximates the extensional evolution of the upper plate which culminated in the development of the Lachlan Fold Belt. The protracted record of eclogite and blueschist metamorphism indicates that rapid exhumation is not necessarily required for preservation of high-pressure metamorphic rocks from subduction systems. Reference: Gerya, T. V., Stockhert, B., & Perchuk, A. L. (2002). Exhumation of high-pressure metamorphic rocks in a subduction channel: A numerical simulation. Tectonics, 21(6), 6-1-6-19. doi:10.1029/2002tc001406

In-vivo evaluation of the kinematic behavior of an artificial medial meniscus implant: A pilot study using open-MRI.

PubMed

De Coninck, Tineke; Elsner, Jonathan J; Linder-Ganz, Eran; Cromheecke, Michiel; Shemesh, Maoz; Huysse, Wouter; Verdonk, René; Verstraete, Koenraad; Verdonk, Peter

2014-09-01

In this pilot study we wanted to evaluate the kinematics of a knee implanted with an artificial polycarbonate-urethane meniscus device, designed for medial meniscus replacement. The static kinematic behavior of the implant was compared to the natural medial meniscus of the non-operated knee. A second goal was to evaluate the motion pattern, the radial displacement and the deformation of the meniscal implant. Three patients with a polycarbonate-urethane implant were included in this prospective study. An open-MRI was used to track the location of the implant during static weight-bearing conditions, within a range of motion of 0° to 120° knee flexion. Knee kinematics were evaluated by measuring the tibiofemoral contact points and femoral roll-back. Meniscus measurements (both natural and artificial) included anterior-posterior meniscal movement, radial displacement, and meniscal height. No difference (P>0.05) was demonstrated in femoral roll-back and tibiofemoral contact points during knee flexion between the implanted and the non-operated knees. Meniscal measurements showed no significant difference in radial displacement and meniscal height (P>0.05) at all flexion angles, in both the implanted and non-operated knees. A significant difference (P ≤ 0.05) in anterior-posterior movement during flexion was observed between the two groups. In this pilot study, the artificial polycarbonate-urethane implant, indicated for medial meniscus replacement, had no influence on femoral roll-back and tibiofemoral contact points, thus suggesting that the joint maintains its static kinematic properties after implantation. Radial displacement and meniscal height were not different, but anterior-posterior movement was slightly different between the implant and the normal meniscus. Copyright © 2014 Elsevier Ltd. All rights reserved.

KSC-07pd3576

NASA Image and Video Library

2007-12-05

KENNEDY SPACE CENTER, FLA. -- Space shuttle Atlantis is revealed on Launch Pad 39A at NASA's Kennedy Space Center after the rotating service structure, or RSS, at left of the pad is rolled back. Rollback was complete at 8:44 p.m. EST. The RSS provides protected access to the orbiter for crew entry and servicing of payloads at the pad. Rollback of the pad's RSS is one of the milestones in preparation for the launch of mission STS-122, scheduled for 4:31 p.m. EST on Dec. 6. Beneath the shuttle is the mobile launcher platform which supports the shuttle until liftoff. Atlantis will carry the Columbus Laboratory, the European Space Agency's largest contribution to the construction of the International Space Station. It will support scientific and technological research in a microgravity environment. Permanently attached to Node 2 of the space station, the laboratory will carry out experiments in materials science, fluid physics and biosciences, as well as perform a number of technological applications. Photo credit: NASA/Kim Shiflett

KSC-07pd3580

NASA Image and Video Library

2007-12-05

KENNEDY SPACE CENTER, FLA. -- Space shuttle Atlantis is revealed on Launch Pad 39A at NASA's Kennedy Space Center after the rotating service structure, or RSS, at left of the pad is rolled back. Rollback was complete at 8:44 p.m. EST. The RSS provides protected access to the orbiter for crew entry and servicing of payloads at the pad. Rollback of the pad's RSS is one of the milestones in preparation for the launch of mission STS-122, scheduled for 4:31 p.m. EST on Dec. 6. Beneath the shuttle is the mobile launcher platform which supports the shuttle until liftoff. Atlantis will carry the Columbus Laboratory, the European Space Agency's largest contribution to the construction of the International Space Station. It will support scientific and technological research in a microgravity environment. Permanently attached to Node 2 of the space station, the laboratory will carry out experiments in materials science, fluid physics and biosciences, as well as perform a number of technological applications. Photo credit: NASA/Kim Shiflett

KSC-2009-2029

NASA Image and Video Library

2009-03-14

CAPE CANAVERAL, Fla. – On Launch Pad 39A at NASA's Kennedy Space Center in Florida, the orbiter access arm and White Room are extended toward space shuttle Discovery after rollback of the rotating service structure. The White Room provides crew access into the shuttle. The rollback is in preparation for Discovery's liftoff on the STS-119 mission with a crew of seven. An earlier launch attempt March 11 was scrubbed at 2:36 p.m. due to a gaseous hydrogen leak from the external tank at the Ground Umbilical Carrier Plate during tanking. A seven-inch quick disconnect and two seals were replaced. The STS-119 mission is the 28th to the International Space Station and the 125th space shuttle flight. Discovery will deliver the final pair of power-generating solar array wings and the S6 truss segment. Installation of S6 will signal the station's readiness to house a six-member crew for conducting increased science. Liftoff of Discovery is scheduled for 7:43 p.m. EDT on March 15. Photo credit: NASA/Jack Pfaller

KSC-2009-2030

NASA Image and Video Library

2009-03-14

CAPE CANAVERAL, Fla. – On Launch Pad 39A at NASA's Kennedy Space Center in Florida, the orbiter access arm and White Room are extended toward space shuttle Discovery after rollback of the rotating service structure. The White Room provides crew access into the shuttle. The rollback is in preparation for Discovery's liftoff on the STS-119 mission with a crew of seven. An earlier launch attempt March 11 was scrubbed at 2:36 p.m. due to a gaseous hydrogen leak from the external tank at the Ground Umbilical Carrier Plate during tanking. A seven-inch quick disconnect and two seals were replaced. The STS-119 mission is the 28th to the International Space Station and the 125th space shuttle flight. Discovery will deliver the final pair of power-generating solar array wings and the S6 truss segment. Installation of S6 will signal the station's readiness to house a six-member crew for conducting increased science. Liftoff of Discovery is scheduled for 7:43 p.m. EDT on March 15. Photo credit: NASA/Jack Pfaller

KSC-2009-2022

NASA Image and Video Library

2009-03-11

CAPE CANAVERAL, Fla. – On Launch Pad 39A at NASA's Kennedy Space Center in Florida, the orbiter access arm and White Room are extended toward space shuttle Discovery after rollback of the rotating service structure. The White Room provides crew access into the shuttle. The rollback is in preparation for Discovery's liftoff on the STS-119 mission with a crew of seven. The rotating structure provides protected access to the shuttle for changeout and servicing of payloads at the pad. After the RSS is rolled back, the orbiter is ready for fuel cell activation and external tank cryogenic propellant loading operations. The mission is the 28th to the International Space Station and the 125th space shuttle flight. Discovery will deliver the final pair of power-generating solar array wings and the S6 truss segment. Installation of S6 will signal the station's readiness to house a six-member crew for conducting increased science. Liftoff of Discovery is scheduled for 9:20 p.m. EDT on March 11. Photo credit: NASA/Kim Shiflett

Slab rollback orogeny in the Alps and evolution of the Swiss Molasse basin

PubMed Central

Schlunegger, Fritz; Kissling, Edi

2015-01-01

The stratigraphies of foreland basins have been related to orogeny, where continent–continent collision causes the construction of topography and the downwarping of the foreland plate. These mechanisms have been inferred for the Molasse basin, stretching along the northern margin of the European Alps. Continuous flexural bending of the subducting European lithosphere as a consequence of topographic loads alone would imply that the Alpine topography would have increased at least between 30 Ma and ca. 5–10 Ma when the basin accumulated the erosional detritus. This, however, is neither consistent with observations nor with isostatic mass balancing models because paleoaltimetry estimates suggest that the topography has not increased since 20 Ma. Here we show that a rollback mechanism for the European plate is capable of explaining the construction of thick sedimentary successions in the Molasse foreland basin where the extra slab load has maintained the Alpine surface at low, but constant, elevations. PMID:26472498

Self-checking self-repairing computer nodes using the mirror processor

NASA Technical Reports Server (NTRS)

Tamir, Yuval

1992-01-01

Circuitry added to fault-tolerant systems for concurrent error deduction usually reduces performance. Using a technique called micro rollback, it is possible to eliminate most of the performance penalty of concurrent error detection. Error detection is performed in parallel with intermodule communication, and erroneous state changes are later undone. The author reports on the design and implementation of a VLSI RISC microprocessor, called the Mirror Processor (MP), which is capable of micro rollback. In order to achieve concurrent error detection, two MP chips operate in lockstep, comparing external signals and a signature of internal signals every clock cycle. If a mismatch is detected, both processors roll back to the beginning of the cycle when the error occurred. In some cases the erroneous state is corrected by copying a value from the fault-free processor to the faulty processor. The architecture, microarchitecture, and VLSI implementation of the MP, emphasizing its error-detection, error-recovery, and self-diagnosis capabilities, are described.

KSC-2010-5887

NASA Image and Video Library

2010-12-21

CAPE CANAVERAL, Fla. -- Space shuttle Discovery awaits its move, called rollback, from Launch Pad 39A to the Vehicle Assembly Building (VAB) at NASA's Kennedy Space Center in Florida. Rollback was scheduled for 12:30 a.m., but was postponed until 10 p.m. so technicians could resolve an issue with a leveling system on the crawler-transporter. Once inside the VAB, Discovery's external fuel tank will be examined and foam reapplied where 89 sensors were installed on the tank's aluminum skin for an instrumented tanking test on Dec. 17. The sensors were used to measure changes in the tank as super-cold propellants were pumped in and drained out. Data and analysis from the test will be used to determine what caused the tops of two, 21-foot-long support beams, called stringers, on the outside of the intertank to crack during fueling on Nov. 5. Discovery's next launch opportunity is no earlier than Feb. 3, 2011. For more information on STS-133, visit www.nasa.gov/mission_pages/shuttle/shuttlemissions/sts133/. Photo credit: NASA/Kim Shiflett

KSC-2010-5923

NASA Image and Video Library

2010-12-21

CAPE CANAVERAL, Fla. -- Space shuttle Discovery, secured to a crawler-transporter, begins its 3.4-mile trek, known as rollback, from Launch Pad 39A to the Vehicle Assembly Building at NASA's Kennedy Space Center in Florida. Rollback began at 10:48 p.m. and took about eight hours. Next, Discovery's external fuel tank will be examined and foam reapplied where 89 sensors were installed on the tank's aluminum skin for an instrumented tanking test on Dec. 17. The sensors were used to measure changes in the tank as super-cold propellants were pumped in and drained out. Data and analysis from the test will be used to determine what caused the tops of two, 21-foot-long support beams, called stringers, on the outside of the intertank to crack during fueling on Nov. 5. Discovery's next launch opportunity to the International Space Station on the STS-133 mission is no earlier than Feb. 3, 2011. For more information on STS-133, visit www.nasa.gov/mission_pages/shuttle/shuttlemissions/sts133/. Photo credit: NASA/Frank Michaux

KSC-2010-5924

NASA Image and Video Library

2010-12-21

CAPE CANAVERAL, Fla. -- Space shuttle Discovery, secured to a crawler-transporter, begins its 3.4-mile trek, known as rollback, from Launch Pad 39A to the Vehicle Assembly Building at NASA's Kennedy Space Center in Florida. Rollback began at 10:48 p.m. and took about eight hours. Next, Discovery's external fuel tank will be examined and foam reapplied where 89 sensors were installed on the tank's aluminum skin for an instrumented tanking test on Dec. 17. The sensors were used to measure changes in the tank as super-cold propellants were pumped in and drained out. Data and analysis from the test will be used to determine what caused the tops of two, 21-foot-long support beams, called stringers, on the outside of the intertank to crack during fueling on Nov. 5. Discovery's next launch opportunity to the International Space Station on the STS-133 mission is no earlier than Feb. 3, 2011. For more information on STS-133, visit www.nasa.gov/mission_pages/shuttle/shuttlemissions/sts133/. Photo credit: NASA/Frank Michaux

KSC-2010-5888

NASA Image and Video Library

2010-12-21

CAPE CANAVERAL, Fla. -- Space shuttle Discovery awaits its move, called rollback, from Launch Pad 39A to the Vehicle Assembly Building (VAB) at NASA's Kennedy Space Center in Florida. Rollback was scheduled for 12:30 a.m., but was postponed until 10 p.m. so technicians could resolve an issue with a leveling system on the crawler-transporter. Once inside the VAB, Discovery's external fuel tank will be examined and foam reapplied where 89 sensors were installed on the tank's aluminum skin for an instrumented tanking test on Dec. 17. The sensors were used to measure changes in the tank as super-cold propellants were pumped in and drained out. Data and analysis from the test will be used to determine what caused the tops of two, 21-foot-long support beams, called stringers, on the outside of the intertank to crack during fueling on Nov. 5. Discovery's next launch opportunity is no earlier than Feb. 3, 2011. For more information on STS-133, visit www.nasa.gov/mission_pages/shuttle/shuttlemissions/sts133/. Photo credit: NASA/Kim Shiflett

KSC-2009-2020

NASA Image and Video Library

2009-03-11

CAPE CANAVERAL, Fla. – On Launch Pad 39A at NASA's Kennedy Space Center in Florida, the orbiter access arm and White Room are extended toward space shuttle Discovery after rollback of the rotating service structure. Above the external tank is the oxygen vent hood, called the "beanie cap." The rollback is in preparation for Discovery's liftoff on the STS-119 mission with a crew of seven. The rotating structure provides protected access to the shuttle for changeout and servicing of payloads at the pad. After the RSS is rolled back, the orbiter is ready for fuel cell activation and external tank cryogenic propellant loading operations. The mission is the 28th to the International Space Station and the 125th space shuttle flight. Discovery will deliver the final pair of power-generating solar array wings and the S6 truss segment. Installation of S6 will signal the station's readiness to house a six-member crew for conducting increased science. Liftoff of Discovery is scheduled for 9:20 p.m. EDT on March 11. Photo credit: NASA/Kim Shiflett

A slab expression in the Gibraltar arc?

NASA Astrophysics Data System (ADS)

Nijholt, Nicolai; Govers, Rob; Wortel, Rinus

2017-04-01

The present-day geodynamic setting of the Gibraltar arc region results from several Myrs of subduction rollback in the overall (oblique) convergence of Africa and Iberia. As for most rollback settings in a convergence zone, the interaction of these two components is complex and distinctly non-stationary. Gibraltar slab rollback is considered to have stalled, or at least diminished largely in magnitude, since the late Miocene/early Pliocene, suggesting that the effect of the slab on present-day surface motions is negligible. However, GPS measurements indicate that the Gibraltar arc region has an anomalous motion with respect to both Iberia and Africa, i.e., the Gibraltar arc region does not move as part of the rigid Iberian, or the rigid African plate. A key question is whether this surface motion is an expression of the Gibraltar slab. Seismic activity in the Gibraltar region is diffuse and considerable in magnitude, making it a region of high seismic risk. Unlike the North African margin to the east, where thrust earthquakes dominate the focal mechanism tables, a complex pattern is observed with thrust, normal and strike-slip earthquakes in a region stretching between the northern Moroccan Atlas across the Gibraltar arc and Alboran Sea (with the Trans-Alboran Shear Zone) to the Betics of southern Spain. Even though no large mega-thrust earthquakes have been observed in recent history, slab rollback may not have completely ceased. However, since no activity has been observed in the accretionary wedge, probably since the Pliocene, it is likely that the subduction interface is locked. In this study, we perform a series of numerical models in which we combine the relative plate convergence, variable magnitude of friction on fault segments, regional variations in gravitational potential energy and slab pull of the Gibraltar slab. We seek to reproduce the GPS velocities and slip sense on regional faults and thereby determine whether the Gibraltar slab has an effect on surface motion. Slab shape and slab continuity to the surface, allowing slab pull to be transfered to the surface lithosphere, are key factors controlling the force balance in the region. We explore slab geometries with or without continuity at the Betics (with a slab window between the known subduction interface and a possible Betics connection) and/or continental material attached to the slab (which lowers the slab pull magnitude). Through our methodology, we are able to study which slab shape of those proposed in the literature best fits the surface data.

Building a generalized distributed system model

NASA Technical Reports Server (NTRS)

Mukkamala, Ravi

1991-01-01

A number of topics related to building a generalized distributed system model are discussed. The effects of distributed database modeling on evaluation of transaction rollbacks, the measurement of effects of distributed database models on transaction availability measures, and a performance analysis of static locking in replicated distributed database systems are covered.

STS-39 Discovery Rollback to the OPF High Bay #2 (Shots of Doors)

NASA Technical Reports Server (NTRS)

1991-01-01

Shown is Discovery rolling back to the Orbiter Processing Facility (OPF) High Bay 2 for repair. High Bay 2, located west of the Vehicle Assembly Building (VAB), is used for external tank (ET) checkout and storage and as a contingency storage area for orbiters.

Subduction Drive of Plate Tectonics

NASA Astrophysics Data System (ADS)

Hamilton, W. B.

2003-12-01

Don Anderson emphasizes that plate tectonics is self-organizing and is driven by subduction, which rights the density inversion generated as oceanic lithosphere forms by cooling of asthenosphere from the top. The following synthesis owes much to many discussions with him. Hinge rollback is the key to kinematics, and, like the rest of actual plate behavior, is incompatible with bottom-up convection drive. Subduction hinges (which are under, not in front of, thin leading parts of arcs and overriding plates) roll back into subducting plates. The Pacific shrinks because bounding hinges roll back into it. Colliding arcs, increasing arc curvatures, back-arc spreading, and advance of small arcs into large plates also require rollback. Forearcs of overriding plates commonly bear basins which preclude shortening of thin plate fronts throughout periods recorded by basin strata (100 Ma for Cretaceous and Paleogene California). This requires subequal rates of advance and rollback, and control of both by subduction. Convergence rate is equal to rates of rollback and advance in many systems but is greater in others. Plate-related circulation probably is closed above 650 km. Despite the popularity of concepts of plumes from, and subduction into, lower mantle, there is no convincing evidence for, and much evidence against, penetration of the 650 in either direction. That barrier not only has a crossing-inhibiting negative Clapeyron slope but also is a compositional boundary between fractionated (not "primitive"), sluggish lower mantle and fertile, mobile upper mantle. Slabs sink more steeply than they dip. Slabs older than about 60 Ma when their subduction began sink to, and lie down on and depress, the 650-km discontinuity, and are overpassed, whereas younger slabs become neutrally buoyant in mid-upper mantle, into which they are mixed as they too are overpassed. Broadside-sinking old slabs push all upper mantle, from base of oceanic lithosphere down to the 650, back under shrinking oceans, forcing rapid Pacific spreading. Slabs suck forward overriding arcs and continental lithosphere, plus most subjacent mantle above the transition zone. Changes in sizes of oceans result primarily from transfer of oceanic lithosphere, so backarcs and expanding oceans spread only slowly. Lithosphere parked in, or displaced from, the transition zone, or mixed into mid-upper mantle, is ultimately recycled, and regional variations in age of that submerged lithosphere may account for some regional contrasts in MORB. Plate motions make no kinematic sense in either the "hotspot" reference frame (HS; the notion of fixed plumes is easily disproved) or the no-net-rotation frame (NNR) In both, for example, many hinges roll forward, impossible with gravity drive. Subduction-drive predictions are fulfilled, and paleomagnetic data are satisfied (as they are not in HS and NNR), in the alternative framework of propulsionless Antarctica fixed relative to sluggish lower mantle. Passive ridges migrate away from Antarctica on all sides, and migration of these and other ridges permits tapping fresh asthenosphere. (HS and NNR tend to fix ridges). Ridge migration and spreading rates accord with subduction drive. All trenches roll back when allowance is made for back-arc spreading and intracontinental deformation. Africa rotates slowly toward subduction systems in the NE, instead of moving rapidly E as in HS and NNR. Stable NW Eurasia is nearly stationary, instead of also moving rapidly, and S and E Eurasian deformation relates to subduction and rollback. The Americas move Pacificward at almost the full spreading rates of passive ridges behind them. Lithosphere has a slow net westward drift. Reference: W.B. Hamilton, An alternative Earth, GSA Today, in press.

Results from CAT/SCAN, the Calabria-Apennine-Tyrrhenian/Subduction-Accretion-Collision Network

NASA Astrophysics Data System (ADS)

Steckler, M. S.; Amato, A.; Guerra, I.; Armbruster, J.; Baccheschi, P.; Diluccio, F.; Gervasi, A.; Harabaglia, P.; Kim, W.; Lerner-Lam, A.; Margheriti, L.; Seeber, L.; Tolstoy, M.; Wilson, C. K.

2005-12-01

The Calabrian Arc region is the final remnant of a Western Mediterranean microplate driven by rollback. Calabria itself is an exotic block that rifted off Sardinia and opened the Tyrrhenian Sea back-arc basin in its wake. The Calabrian Arc rapidly advanced to the southeast, with subduction ahead and extension behind, following subduction rollback of the Mesozoic seafloor. The subduction zone meanwhile collided progressively with the Apulia to form the Apennines in peninsular Italy and with the Africa to form the Maghrebides in Sicily. The Calabrian Arc is where the transition from subduction to continental collision is occurring. The collisions on either side of Calabria have restricted oceanic subduction to a narrow 200-km salient with well-defined edges and seismicity that extends to over 500 km depth. The collisions have also slowed, or possibly even halted, the rapid advance of the arc. Whether rollback of the oceanic lower plate of the Ionian Sea continues and whether the upper plate of Calabria continues to move as an independent plate are both uncertain. The Calabrian-Apennine-Tyrrhenian/Subduction-Collision-Accretion Network (CAT/SCAN) is a passive experiment to study of the Calabrian Arc and the transition to the southern Apennines. The land deployment consisted of three phases. The initial phase included an array of 39 broadband seismometers onshore, deployed in the winter of 2003/4. In September 2004, the array was reduced to 28 broadband and 8 short-period instruments. In April 2005, the array was reduced once again to 20 broadband and 2 short-period instruments. The field deployment was completed in October 2005. Offshore, 12 broadband Ocean Bottom Seismometers (OBSs) were deployed in the beginning of October 2004. Data from 4 OBSs have been recovered so far with deployment durations from a few weeks to almost one year. Fishing activity has been strongly implicated in the early recoveries, (with one instrument returned by fishermen), and is suspected for the instruments that were not recovered. The experiment is determining the structure of the Calabrian subduction and southern Apennine collision systems and the structure of the transition from oceanic subduction in Calabria to continental collision in the southern Apennines. We have delineated a strong anisotropy with a fast direction following the curved arc, but weaker anisotropy beneath the Tyrrhenian Sea. Receiver function images show variations in crustal thickness throughout the region, consistent with previous conceptual models. We also image a negative polarity interface dipping to the southwest that we interpret as the main thrust ramp in the north transitioning to the subduction interface in the south. The transition from one to the other is marked by a loss of amplitude in the Moho conversion. Local seismicity is consistent with surface structure in showing extension normal and parallel to the Calabrian forearc as well as continuing southeastward motion of Calabria relative to the southern Apennines and Maghrebides.

Malaria control in Nicaragua: social and political influences on disease transmission and control activities.

PubMed

Garfield, R

1999-07-31

Throughout Central America, a traditional malaria control strategy (depending on heavy use of organic pesticides) became less effective during the 1970s. In Nicaragua, an alternative strategy, based on frequent local epidemiological assessments and community participation, was developed in the 1980s. Despite war-related social instability, and continuing vector resistance, this approach was highly successful. By the end of the contra war, there finally existed organisational and ecological conditions that favoured improved malaria control. Yet the expected improvements did not occur. In the 1990s, Nicaragua experienced its worst recorded malaria epidemics. This situation was partly caused by the country's macroeconomic structural adjustment programme. Volunteers now take fewer slides and provide less treatment, malaria control workers are less motivated by the spirit of public service, and some malaria control stations charge for diagnosis or treatment. To "roll back malaria", in Nicaragua at least, will require the roll-back of some erroneous aspects of structural adjustment.

Insights Into the Causes of Arc Rifting From 2-D Dynamic Models of Subduction

NASA Astrophysics Data System (ADS)

Billen, Magali I.

2017-11-01

Back-arc spreading centers initiate as fore-arc or arc rifting events when extensional forces localize within lithosphere weakened by hydrous fluids or melting. Two models have been proposed for triggering fore-arc/arc rifting: rollback of the subducting plate causing trench retreat or motion of the overriding plate away from the subduction zone. This paper demonstrates that there is a third mechanism caused by an in situ instability that occurs when the thin high-viscosity boundary, which separates the weak fore arc from the hot buoyant mantle wedge, is removed. Buoyant upwelling mantle causes arc rifting, drives the overriding plate away from the subducting plate, and there is sufficient heating of the subducting plate crust and overriding plate lithosphere to form adakite or boninite volcanism. For spontaneous fore-arc/arc rifting to occur a broad region of weak material must be present and one of the plates must be free to respond to the upwelling forces.

Volcanism in slab tear faults is larger than in island-arcs and back-arcs.

PubMed

Cocchi, Luca; Passaro, Salvatore; Tontini, Fabio Caratori; Ventura, Guido

2017-11-13

Subduction-transform edge propagators are lithospheric tears bounding slabs and back-arc basins. The volcanism at these edges is enigmatic because it is lacking comprehensive geological and geophysical data. Here we present bathymetric, potential-field data, and direct observations of the seafloor on the 90 km long Palinuro volcanic chain overlapping the E-W striking tear of the roll-backing Ionian slab in Southern Tyrrhenian Sea. The volcanic chain includes arc-type central volcanoes and fissural, spreading-type centers emplaced along second-order shears. The volume of the volcanic chain is larger than that of the neighbor island-arc edifices and back-arc spreading center. Such large volume of magma is associated to an upwelling of the isotherms due to mantle melts upraising from the rear of the slab along the tear fault. The subduction-transform edge volcanism focuses localized spreading processes and its magnitude is underestimated. This volcanism characterizes the subduction settings associated to volcanic arcs and back-arc spreading centers.

Ed Reform Rollback in New York City

ERIC Educational Resources Information Center

Eide, Stephen

2017-01-01

In his campaign for Mayor of New York City, Bill de Blasio positioned himself as the candidate most determined to break with the legacy of the outgoing Michael Bloomberg administration. Voters responded enthusiastically, handing de Blasio a nearly 50-point margin of victory in the November 2013 election. De Blasio, a Democrat, interpreted the win…

Competitiveness of biomass-fueled electrical power plants.

Treesearch

Bruce A. McCarl; Darius M. Adams; Ralph J. Alig; John T. Chmelik

2000-01-01

One way countries like the United States can comply with suggested rollbacks in greenhouse gas emissions is by employing power plants fueled with biomass. We examine the competitiveness of biomass-based fuel for electrical power as opposed to coal using a mathematical programming structure. We consider fueling power plants from milling residues, whole trees, logging...

Decomposing School Resegregation: Social Closure, Racial Imbalance, and Racial Isolation

ERIC Educational Resources Information Center

Fiel, Jeremy E.

2013-01-01

Today's typical minority student attends school with fewer whites than his counterpart in 1970. This apparent resegregation of U.S. schools has sparked outrage and debate. Some blame a rollback of desegregation policies designed to distribute students more evenly among schools; others blame the changing racial composition of the student…

KSC-2009-2031

NASA Image and Video Library

2009-03-14

CAPE CANAVERAL, Fla. – Lights glow on the structures on Launch Pad 39A at NASA's Kennedy Space Center in Florida, after rollback of the rotating service structure from around space shuttle Discovery. The orbiter access arm and White Room are extended toward Discovery The White Room provides crew access into the shuttle. The rollback is in preparation for Discovery's liftoff on the STS-119 mission with a crew of seven. An earlier launch attempt March 11 was scrubbed at 2:36 p.m. due to a gaseous hydrogen leak from the external tank at the Ground Umbilical Carrier Plate during tanking. A seven-inch quick disconnect and two seals were replaced. The STS-119 mission is the 28th to the International Space Station and the 125th space shuttle flight. Discovery will deliver the final pair of power-generating solar array wings and the S6 truss segment. Installation of S6 will signal the station's readiness to house a six-member crew for conducting increased science. Liftoff of Discovery is scheduled for 7:43 p.m. EDT on March 15. Photo credit: NASA/Jack Pfaller

Message Efficient Checkpointing and Rollback Recovery in Heterogeneous Mobile Networks

NASA Astrophysics Data System (ADS)

Jaggi, Parmeet Kaur; Singh, Awadhesh Kumar

2016-06-01

Heterogeneous networks provide an appealing way of expanding the computing capability of mobile networks by combining infrastructure-less mobile ad-hoc networks with the infrastructure-based cellular mobile networks. The nodes in such a network range from low-power nodes to macro base stations and thus, vary greatly in their capabilities such as computation power and battery power. The nodes are susceptible to different types of transient and permanent failures and therefore, the algorithms designed for such networks need to be fault-tolerant. The article presents a checkpointing algorithm for the rollback recovery of mobile hosts in a heterogeneous mobile network. Checkpointing is a well established approach to provide fault tolerance in static and cellular mobile distributed systems. However, the use of checkpointing for fault tolerance in a heterogeneous environment remains to be explored. The proposed protocol is based on the results of zigzag paths and zigzag cycles by Netzer-Xu. Considering the heterogeneity prevalent in the network, an uncoordinated checkpointing technique is employed. Yet, useless checkpoints are avoided without causing a high message overhead.

Hurricane Properties for KSC and Mid-Florida Coastal Sites

NASA Technical Reports Server (NTRS)

Johnson, Dale L.; Rawlins, Michael A.; Kross, Dennis A.

2000-01-01

Hurricane information and climatologies are needed at Kennedy Space Center (KSC) Florida for launch operational planning purposes during the late summer and early fall Atlantic hurricane season. Also these results are needed to be used in estimating the potential magnitudes of hurricane and tropical storm impact on coastal Florida sites when passing within 50, 100 and 400 nm of that site. Roll-backs of the Space Shuttle and other launch vehicles, on pad, are very costly when a tropical storm approaches. A decision for the vehicle to roll-back or ride-out needs to be made. Therefore the historical Atlantic basin hurricane climatological properties were generated to be used for operational planning purposes and in the estimation of potential damage to launch vehicles, supporting equipment, buildings, etc.. The historical 1885-1998 Atlantic basin hurricane data were compiled and analyzed with respect to the coastal Florida site of KSC. Statistical information generated includes hurricane and tropical storm probabilities for path, maximum wind, and lowest pressure, presented for the areas within 50, 100 and 400 nm of KSC. These statistics are then compared to similar parametric statistics for the entire Atlantic basin.

Read buffer optimizations to support compiler-assisted multiple instruction retry

NASA Technical Reports Server (NTRS)

Alewine, N. J.; Fuchs, W. K.; Hwu, W. M.

1993-01-01

Multiple instruction retry is a recovery mechanism for transient processor faults. We previously developed a compiler-assisted approach to multiple instruction ferry in which a read buffer of size 2N (where N represents the maximum instruction rollback distance) was used to resolve some data hazards while the compiler resolved the remaining hazards. The compiler-assisted scheme was shown to reduce the performance overhead and/or hardware complexity normally associated with hardware-only retry schemes. This paper examines the size and design of the read buffer. We establish a practical lower bound and average size requirement for the read buffer by modifying the scheme to save only the data required for rollback. The study measures the effect on the performance of a DECstation 3100 running ten application programs using six read buffer configurations with varying read buffer sizes. Two alternative configurations are shown to be the most efficient and differed depending on whether split-cycle-saves are assumed. Up to a 55 percent read buffer size reduction is achievable with an average reduction of 39 percent given the most efficient read buffer configuration and a variety of applications.

KSC-2010-5917

NASA Image and Video Library

2010-12-21

CAPE CANAVERAL, Fla. -- Space shuttle Discovery awaits its move, called rollback, from Launch Pad 39A to the Vehicle Assembly Building (VAB) at NASA's Kennedy Space Center in Florida. Rollback was scheduled for 12:30 a.m., but was postponed until 10 p.m. so technicians could resolve an issue with a leveling system on the crawler-transporter, which is in front of the shuttle. Once inside the VAB, Discovery's external fuel tank will be examined and foam reapplied where 89 sensors were installed on the tank's aluminum skin for an instrumented tanking test on Dec. 17. The sensors were used to measure changes in the tank as super-cold propellants were pumped in and drained out. Data and analysis from the test will be used to determine what caused the tops of two, 21-foot-long support beams, called stringers, on the outside of the intertank to crack during fueling on Nov. 5. Discovery's next launch opportunity to the International Space Station on the STS-133 mission is no earlier than Feb. 3, 2011. For more information on STS-133, visit www.nasa.gov/mission_pages/shuttle/shuttlemissions/sts133/. Photo credit: NASA/Frank Michaux

KSC-2010-5913

NASA Image and Video Library

2010-12-21

CAPE CANAVERAL, Fla. -- Space shuttle Discovery awaits its move, called rollback, from Launch Pad 39A to the Vehicle Assembly Building (VAB) at NASA's Kennedy Space Center in Florida. Rollback was scheduled for 12:30 a.m., but was postponed until 10 p.m. so technicians could resolve an issue with a leveling system on the crawler-transporter, which is in front of the shuttle. Once inside the VAB, Discovery's external fuel tank will be examined and foam reapplied where 89 sensors were installed on the tank's aluminum skin for an instrumented tanking test on Dec. 17. The sensors were used to measure changes in the tank as super-cold propellants were pumped in and drained out. Data and analysis from the test will be used to determine what caused the tops of two, 21-foot-long support beams, called stringers, on the outside of the intertank to crack during fueling on Nov. 5. Discovery's next launch opportunity to the International Space Station on the STS-133 mission is no earlier than Feb. 3, 2011. For more information on STS-133, visit www.nasa.gov/mission_pages/shuttle/shuttlemissions/sts133/. Photo credit: NASA/Frank Michaux

KSC-2010-5905

NASA Image and Video Library

2010-12-21

CAPE CANAVERAL, Fla. -- Space shuttle Discovery awaits its move, called rollback, from Launch Pad 39A to the Vehicle Assembly Building (VAB) at NASA's Kennedy Space Center in Florida. Rollback was scheduled for 12:30 a.m., but was postponed until 10 p.m. so technicians could resolve an issue with a leveling system on the crawler-transporter. Once inside the VAB, Discovery's external fuel tank will be examined and foam reapplied where 89 sensors were installed on the tank's aluminum skin for an instrumented tanking test on Dec. 17. The sensors were used to measure changes in the tank as super-cold propellants were pumped in and drained out. Data and analysis from the test will be used to determine what caused the tops of two, 21-foot-long support beams, called stringers, on the outside of the intertank to crack during fueling on Nov. 5. Discovery's next launch opportunity to the International Space Station on the STS-133 mission is no earlier than Feb. 3, 2011. For more information on STS-133, visit www.nasa.gov/mission_pages/shuttle/shuttlemissions/sts133/. Photo credit: NASA/Frank Michaux

KSC-2010-5910

NASA Image and Video Library

2010-12-21

CAPE CANAVERAL, Fla. -- Space shuttle Discovery awaits its move, called rollback, from Launch Pad 39A to the Vehicle Assembly Building (VAB) at NASA's Kennedy Space Center in Florida. Rollback was scheduled for 12:30 a.m., but was postponed until 10 p.m. so technicians could resolve an issue with a leveling system on the crawler-transporter, which is in front of the shuttle. Once inside the VAB, Discovery's external fuel tank will be examined and foam reapplied where 89 sensors were installed on the tank's aluminum skin for an instrumented tanking test on Dec. 17. The sensors were used to measure changes in the tank as super-cold propellants were pumped in and drained out. Data and analysis from the test will be used to determine what caused the tops of two, 21-foot-long support beams, called stringers, on the outside of the intertank to crack during fueling on Nov. 5. Discovery's next launch opportunity to the International Space Station on the STS-133 mission is no earlier than Feb. 3, 2011. For more information on STS-133, visit www.nasa.gov/mission_pages/shuttle/shuttlemissions/sts133/. Photo credit: NASA/Frank Michaux

STS-90 Columbia RSS rollback

NASA Technical Reports Server (NTRS)

1998-01-01

With the Rotating Service Structure (RSS) rolled back, at left, the Space Shuttle Columbia is nearly ready for launch of STS-90. Rollback of the RSS is a major preflight milestone, typically occurring during the T-11-hour hold on L-1 (the day before launch). The scheduled launch of Columbia on Apr. 16 from Launch Pad 39B was postponed 24 hours due to difficulty with network signal processor No. 2 on the orbiter. This device formats data and voice communications between the ground and the Space Shuttle. The unit, which is located in the orbiter's mid-deck, will be removed and replaced. Prior to launch, one of the final steps will be to load the external tank with approximately 500,000 gallons of liquid hydrogen and liquid oxygen for fueling the orbiters three main engines. Tanking had not yet begun when the launch scheduled for Apr. 16 was scrubbed. STS-90 is slated to be the launch of Neurolab, a nearly 17-day mission to examine the effects of spaceflight on the brain, spinal cord, peripheral nerves and sensory organs in the human body.

KSC-2010-5904

NASA Image and Video Library

2010-12-21

CAPE CANAVERAL, Fla. -- Space shuttle Discovery awaits its move, called rollback, from Launch Pad 39A to the Vehicle Assembly Building (VAB) at NASA's Kennedy Space Center in Florida. Rollback was scheduled for 12:30 a.m., but was postponed until 10 p.m. so technicians could resolve an issue with a leveling system on the crawler-transporter. Once inside the VAB, Discovery's external fuel tank will be examined and foam reapplied where 89 sensors were installed on the tank's aluminum skin for an instrumented tanking test on Dec. 17. The sensors were used to measure changes in the tank as super-cold propellants were pumped in and drained out. Data and analysis from the test will be used to determine what caused the tops of two, 21-foot-long support beams, called stringers, on the outside of the intertank to crack during fueling on Nov. 5. Discovery's next launch opportunity to the International Space Station on the STS-133 mission is no earlier than Feb. 3, 2011. For more information on STS-133, visit www.nasa.gov/mission_pages/shuttle/shuttlemissions/sts133/. Photo credit: NASA/Frank Michaux

KSC-2010-5907

NASA Image and Video Library

2010-12-21

CAPE CANAVERAL, Fla. -- Space shuttle Discovery awaits its move, called rollback, from Launch Pad 39A to the Vehicle Assembly Building (VAB) at NASA's Kennedy Space Center in Florida. Rollback was scheduled for 12:30 a.m., but was postponed until 10 p.m. so technicians could resolve an issue with a leveling system on the crawler-transporter. Once inside the VAB, Discovery's external fuel tank will be examined and foam reapplied where 89 sensors were installed on the tank's aluminum skin for an instrumented tanking test on Dec. 17. The sensors were used to measure changes in the tank as super-cold propellants were pumped in and drained out. Data and analysis from the test will be used to determine what caused the tops of two, 21-foot-long support beams, called stringers, on the outside of the intertank to crack during fueling on Nov. 5. Discovery's next launch opportunity to the International Space Station on the STS-133 mission is no earlier than Feb. 3, 2011. For more information on STS-133, visit www.nasa.gov/mission_pages/shuttle/shuttlemissions/sts133/. Photo credit: NASA/Frank Michaux

KSC-2010-5916

NASA Image and Video Library

2010-12-21

CAPE CANAVERAL, Fla. -- Space shuttle Discovery awaits its move, called rollback, from Launch Pad 39A to the Vehicle Assembly Building (VAB) at NASA's Kennedy Space Center in Florida. Rollback was scheduled for 12:30 a.m., but was postponed until 10 p.m. so technicians could resolve an issue with a leveling system on the crawler-transporter, which is in front of the shuttle. Once inside the VAB, Discovery's external fuel tank will be examined and foam reapplied where 89 sensors were installed on the tank's aluminum skin for an instrumented tanking test on Dec. 17. The sensors were used to measure changes in the tank as super-cold propellants were pumped in and drained out. Data and analysis from the test will be used to determine what caused the tops of two, 21-foot-long support beams, called stringers, on the outside of the intertank to crack during fueling on Nov. 5. Discovery's next launch opportunity to the International Space Station on the STS-133 mission is no earlier than Feb. 3, 2011. For more information on STS-133, visit www.nasa.gov/mission_pages/shuttle/shuttlemissions/sts133/. Photo credit: NASA/Frank Michaux

KSC-2010-5914

NASA Image and Video Library

2010-12-21

CAPE CANAVERAL, Fla. -- Space shuttle Discovery awaits its move, called rollback, from Launch Pad 39A to the Vehicle Assembly Building (VAB) at NASA's Kennedy Space Center in Florida. Rollback was scheduled for 12:30 a.m., but was postponed until 10 p.m. so technicians could resolve an issue with a leveling system on the crawler-transporter. Once inside the VAB, Discovery's external fuel tank will be examined and foam reapplied where 89 sensors were installed on the tank's aluminum skin for an instrumented tanking test on Dec. 17. The sensors were used to measure changes in the tank as super-cold propellants were pumped in and drained out. Data and analysis from the test will be used to determine what caused the tops of two, 21-foot-long support beams, called stringers, on the outside of the intertank to crack during fueling on Nov. 5. Discovery's next launch opportunity to the International Space Station on the STS-133 mission is no earlier than Feb. 3, 2011. For more information on STS-133, visit www.nasa.gov/mission_pages/shuttle/shuttlemissions/sts133/. Photo credit: NASA/Frank Michaux

KSC-2010-5912

NASA Image and Video Library

2010-12-21

CAPE CANAVERAL, Fla. -- Space shuttle Discovery awaits its move, called rollback, from Launch Pad 39A to the Vehicle Assembly Building (VAB) at NASA's Kennedy Space Center in Florida. Rollback was scheduled for 12:30 a.m., but was postponed until 10 p.m. so technicians could resolve an issue with a leveling system on the crawler-transporter, which is in front of the shuttle. Once inside the VAB, Discovery's external fuel tank will be examined and foam reapplied where 89 sensors were installed on the tank's aluminum skin for an instrumented tanking test on Dec. 17. The sensors were used to measure changes in the tank as super-cold propellants were pumped in and drained out. Data and analysis from the test will be used to determine what caused the tops of two, 21-foot-long support beams, called stringers, on the outside of the intertank to crack during fueling on Nov. 5. Discovery's next launch opportunity to the International Space Station on the STS-133 mission is no earlier than Feb. 3, 2011. For more information on STS-133, visit www.nasa.gov/mission_pages/shuttle/shuttlemissions/sts133/. Photo credit: NASA/Frank Michaux

KSC-2010-5903

NASA Image and Video Library

2010-12-21

CAPE CANAVERAL, Fla. -- Space shuttle Discovery awaits its move, called rollback, from Launch Pad 39A to the Vehicle Assembly Building (VAB) at NASA's Kennedy Space Center in Florida. Rollback was scheduled for 12:30 a.m., but was postponed until 10 p.m. so technicians could resolve an issue with a leveling system on the crawler-transporter. Once inside the VAB, Discovery's external fuel tank will be examined and foam reapplied where 89 sensors were installed on the tank's aluminum skin for an instrumented tanking test on Dec. 17. The sensors were used to measure changes in the tank as super-cold propellants were pumped in and drained out. Data and analysis from the test will be used to determine what caused the tops of two, 21-foot-long support beams, called stringers, on the outside of the intertank to crack during fueling on Nov. 5. Discovery's next launch opportunity to the International Space Station on the STS-133 mission is no earlier than Feb. 3, 2011. For more information on STS-133, visit www.nasa.gov/mission_pages/shuttle/shuttlemissions/sts133/. Photo credit: NASA/Frank Michaux

KSC-2010-5911

NASA Image and Video Library

2010-12-21

CAPE CANAVERAL, Fla. -- Space shuttle Discovery awaits its move, called rollback, from Launch Pad 39A to the Vehicle Assembly Building (VAB) at NASA's Kennedy Space Center in Florida. Rollback was scheduled for 12:30 a.m., but was postponed until 10 p.m. so technicians could resolve an issue with a leveling system on the crawler-transporter, which is in front of the shuttle. Once inside the VAB, Discovery's external fuel tank will be examined and foam reapplied where 89 sensors were installed on the tank's aluminum skin for an instrumented tanking test on Dec. 17. The sensors were used to measure changes in the tank as super-cold propellants were pumped in and drained out. Data and analysis from the test will be used to determine what caused the tops of two, 21-foot-long support beams, called stringers, on the outside of the intertank to crack during fueling on Nov. 5. Discovery's next launch opportunity to the International Space Station on the STS-133 mission is no earlier than Feb. 3, 2011. For more information on STS-133, visit www.nasa.gov/mission_pages/shuttle/shuttlemissions/sts133/. Photo credit: NASA/Frank Michaux

KSC-2010-5915

NASA Image and Video Library

2010-12-21

CAPE CANAVERAL, Fla. -- Space shuttle Discovery awaits its move, called rollback, from Launch Pad 39A to the Vehicle Assembly Building (VAB) at NASA's Kennedy Space Center in Florida. Rollback was scheduled for 12:30 a.m., but was postponed until 10 p.m. so technicians could resolve an issue with a leveling system on the crawler-transporter, which is in front of the shuttle. Once inside the VAB, Discovery's external fuel tank will be examined and foam reapplied where 89 sensors were installed on the tank's aluminum skin for an instrumented tanking test on Dec. 17. The sensors were used to measure changes in the tank as super-cold propellants were pumped in and drained out. Data and analysis from the test will be used to determine what caused the tops of two, 21-foot-long support beams, called stringers, on the outside of the intertank to crack during fueling on Nov. 5. Discovery's next launch opportunity to the International Space Station on the STS-133 mission is no earlier than Feb. 3, 2011. For more information on STS-133, visit www.nasa.gov/mission_pages/shuttle/shuttlemissions/sts133/. Photo credit: NASA/Frank Michaux

Multiple Alternatives for Educational Evaluation and Decision-Making. Interim Draft. Paper and Report Series No. 72.

ERIC Educational Resources Information Center

Wholeben, Brent E.

This volume is an exposition of a mathematical modeling technique for use in the evaluation and solution of complex educational problems at all levels. It explores in detail the application of simple algebraic techniques to such issues as program reduction, fiscal rollbacks, and computer curriculum planning. Part I ("Introduction to the…

Structural Evolution of the Crotone Basin: Successive Shortening and Extension Episodes Parallel to the Calabrian Forearc (South Italy)

NASA Astrophysics Data System (ADS)

Reitz, M.; Seeber, L.

2008-12-01

At 10-12 Ma, the continental fragment of Calabria separated from Sardinia and became the crystalline core of a forearc in a NW-directed subduction system that is being consuming the Mesozoic (Neo-Tethys) oceanic lithosphere. The southeastward rollback of this arc has left in its wake the Tyrrhenian Sea by back-arc spreading. This system is confined between the continental margins of Africa and its Apulian promontory and created matching oblique-collision orogens (Sicilian Maghrebides and Apennines, respectively) along the margins. These progressive collisions shortened the arc because the gap between the margins narrowed to the SE. However, the arc is now lengthening after passing the point of closest approach of Sicily and Apulia, probably in the Quaternary. We seek evidence of this and other neotectonic episodes in the evolution of the forearc in the Crotone basin, which is situated on the accretionary E side of Calabria. A widespread unconformity correlated with the onset of rollback marks a regional foundering controlled by multidirectional extensional growth faults. These faults are consistently capped by the Messinian evaporite sequence. This sequence ends with a widespread unconformity that marks the final desiccation of the Ionian Sea ~5Ma. Mechanical changes due to drop in pore pressure and backward tilting of the accretionary wedge due to flexural unloading may be responsible for the landward emplacement of an accretionary mélange on the NE side of the Crotone Basin and the deposition of a characteristic conglomerate that locally caps the evaporites. After a well known mid-Pliocene basin-forming extensional event, we find evidence for a basin- wide contraction affecting the entire Neogene sequence up to the mid-to-late Pliocene. Vergence ranges from N to NW from east to west across the basin and is consistent with longitudinal shortening of the forearc. The shortening structures are cut or reactivated(?) by extensional faulting which we associate with Late(?) Quaternary longitudinal extension manifested by several transverse basins across the Calabrian forearc.

Plume-induced roll back subduction around Venus large coronae

NASA Astrophysics Data System (ADS)

Davaille, A.; Smrekar, S. E.; Tomlinson, S. M.

2016-12-01

On Venus, possible subduction trenches are mainly associated with large coronae, eventhough the latter are thought to be produced by hot mantle plumes. The mechanism of assocation between subduction and plume has long remained elusive. However, we recently observe the same association in laboratory experiments on thermal convection in colloidal aqueous dispersions of silica nanoparticles, which deform in the Newtonian regime at low solid particle fraction φp, and transition to strain-rate weakening, plasticity, elasticity, and brittle properties as φp increases. Hence, a dense skin akin to a planetary lithosphere grows on the surface when the system is dried from above. When a hot plume rises under the skin, the latter undergoes a flexural deformation which puts it under tension. Cracks then develop, sometimes using pre-existing weaknesses. Plume material (being more buoyant that the laboratory lithosphere) upwells through the cracks and spreads as a axisymmetric gravity current above the broken denser skin. The latter bends and sinks under the conjugate action of its own weight and the plume gravity current. The brittle character of the top experimental lithosphere forbids it to deform viscously to accomodate the sinking motions. Instead, the plate continues to tear as a sheet of paper would do upon intrusion. Several slabs are therefore produced, associated with trenches localized along partial circles on the plume, and strong roll-back is always observed. Depending on the lithospheric strength, roll-back can continue and triggers a complete resurfacing, or it stops when the plume stops spreading. Scalings derived from the experiments suggest that a weaker lithosphere than that present on Earth today is required for such a convective regime. We identified two candidates on Venus. At Artemis and Quetzelpetlatl Coronae, the radar image observations and subsurface density variations inferred from modeling the gravity and topography agree with the predictions from the laboratory. Evidence for geologically recent volcanism at Quetzelpetlatl further suggests that subduction may be currently active on Venus. However, a more complete appraisal of this mechanism for Venus resurfacing will require a better knowledge of Venus topography and gravity field, such as proposed by the future mission VERITAS.

Cost-Effectiveness Analysis of Intensity Modulated Radiation Therapy Versus 3-Dimensional Conformal Radiation Therapy for Preoperative Treatment of Extremity Soft Tissue Sarcomas

DOE Office of Scientific and Technical Information (OSTI.GOV)

Richard, Patrick, E-mail: patrjr@uw.edu; Phillips, Mark; Smith, Wade

Purpose: Create a cost-effectiveness model comparing preoperative intensity modulated radiation therapy (IMRT) versus 3-dimensional conformal radiation therapy (3DCRT) for extremity soft tissue sarcomas. Methods and Materials: Input parameters included 5-year local recurrence rates, rates of acute wound adverse events, and chronic toxicities (edema, fracture, joint stiffness, and fibrosis). Health-state utilities were used to calculate quality-adjusted life years (QALYs). Overall treatment costs per QALY or incremental cost-effectiveness ratio (ICER) were calculated. Roll-back analysis was performed using average costs and utilities to determine the baseline preferred radiation technique. One-way, 2-way, and probabilistic sensitivity analyses (PSA) were performed for input parameters with themore » largest impact on the ICER. Results: Overall treatment costs were $17,515.58 for 3DCRT compared with $22,920.51 for IMRT. The effectiveness was higher for IMRT (3.68 QALYs) than for 3DCRT (3.35 QALYs). The baseline ICER for IMRT was $16,842.75/QALY, making it the preferable treatment. The ICER was most sensitive to the probability of local recurrence, upfront radiation costs, local recurrence costs, certain utilities (no toxicity/no recurrence, grade 1 toxicity/no local recurrence, grade 4 toxicity/no local recurrence), and life expectancy. Dominance patterns emerged when the cost of 3DCRT exceeded $15,532.05 (IMRT dominates) or the life expectancy was under 1.68 years (3DCRT dominates). Furthermore, preference patterns changed based on the rate of local recurrence (threshold: 13%). The PSA results demonstrated that IMRT was the preferred cost-effective technique for 64% of trials compared with 36% for 3DCRT. Conclusions: Based on our model, IMRT is the preferred technique by lowering rates of local recurrence, severe toxicities, and improving QALYs. From a third-party payer perspective, IMRT should be a supported approach for extremity soft tissue sarcomas.« less

Considerations for Consortia as States Transition Away from AA-MAS. NCEO Brief. Number 7

ERIC Educational Resources Information Center

National Center on Educational Outcomes, 2014

2014-01-01

States with an alternate assessment based on modified achievement standards (AA-MAS) that received a flexibility waiver from some of the requirements of No Child Left Behind are required to phase out their use of this assessment. And, on August 23, 2013, the U.S. Department of Education published a proposed rollback of regulation that allowed the…

Implementation of Tree and Butterfly Barriers with Optimistic Time Management Algorithms for Discrete Event Simulation

NASA Astrophysics Data System (ADS)

Rizvi, Syed S.; Shah, Dipali; Riasat, Aasia

The Time Wrap algorithm [3] offers a run time recovery mechanism that deals with the causality errors. These run time recovery mechanisms consists of rollback, anti-message, and Global Virtual Time (GVT) techniques. For rollback, there is a need to compute GVT which is used in discrete-event simulation to reclaim the memory, commit the output, detect the termination, and handle the errors. However, the computation of GVT requires dealing with transient message problem and the simultaneous reporting problem. These problems can be dealt in an efficient manner by the Samadi's algorithm [8] which works fine in the presence of causality errors. However, the performance of both Time Wrap and Samadi's algorithms depends on the latency involve in GVT computation. Both algorithms give poor latency for large simulation systems especially in the presence of causality errors. To improve the latency and reduce the processor ideal time, we implement tree and butterflies barriers with the optimistic algorithm. Our analysis shows that the use of synchronous barriers such as tree and butterfly with the optimistic algorithm not only minimizes the GVT latency but also minimizes the processor idle time.

Ice Crystal Icing Research at NASA

NASA Technical Reports Server (NTRS)

Flegel, Ashlie B.

2017-01-01

Ice crystals found at high altitude near convective clouds are known to cause jet engine power-loss events. These events occur due to ice crystals entering a propulsion system's core flowpath and accreting ice resulting in events such as uncommanded loss of thrust (rollback), engine stall, surge, and damage due to ice shedding. As part of a community with a growing need to understand the underlying physics of ice crystal icing, NASA has been performing experimental efforts aimed at providing datasets that can be used to generate models to predict the ice accretion inside current and future engine designs. Fundamental icing physics studies on particle impacts, accretion on a single airfoil, and ice accretions observed during a rollback event inside a full-scale engine in the Propulsion Systems Laboratory are summarized. Low fidelity code development using the results from the engine tests which identify key parameters for ice accretion risk and the development of high fidelity codes are described. These activities have been conducted internal to NASA and through collaboration efforts with industry, academia, and other government agencies. The details of the research activities and progress made to date in addressing ice crystal icing research challenges are discussed.

Ice Crystal Icing Research at NASA

NASA Technical Reports Server (NTRS)

Flegel, Ashlie B.

2017-01-01

Ice crystals found at high altitude near convective clouds are known to cause jet engine power-loss events. These events occur due to ice crystals entering a propulsion systems core flowpath and accreting ice resulting in events such as uncommanded loss of thrust (rollback), engine stall, surge, and damage due to ice shedding. As part of a community with a growing need to understand the underlying physics of ice crystal icing, NASA has been performing experimental efforts aimed at providing datasets that can be used to generate models to predict the ice accretion inside current and future engine designs. Fundamental icing physics studies on particle impacts, accretion on a single airfoil, and ice accretions observed during a rollback event inside a full-scale engine in the Propulsion Systems Laboratory are summarized. Low fidelity code development using the results from the engine tests which identify key parameters for ice accretion risk and the development of high fidelity codes are described. These activities have been conducted internal to NASA and through collaboration efforts with industry, academia, and other government agencies. The details of the research activities and progress made to date in addressing ice crystal icing research challenges are discussed.

KSC-2010-5909

NASA Image and Video Library

2010-12-21

CAPE CANAVERAL, Fla. -- Space shuttle Discovery awaits its move, called rollback, from Launch Pad 39A to the Vehicle Assembly Building (VAB) at NASA's Kennedy Space Center in Florida. Rollback was scheduled for 12:30 a.m., but was postponed until 10 p.m. so technicians could resolve an issue with a leveling system on the crawler-transporter, which is to the left of the shuttle. Once inside the VAB, Discovery's external fuel tank will be examined and foam reapplied where 89 sensors were installed on the tank's aluminum skin for an instrumented tanking test on Dec. 17. The sensors were used to measure changes in the tank as super-cold propellants were pumped in and drained out. Data and analysis from the test will be used to determine what caused the tops of two, 21-foot-long support beams, called stringers, on the outside of the intertank to crack during fueling on Nov. 5. Discovery's next launch opportunity to the International Space Station on the STS-133 mission is no earlier than Feb. 3, 2011. For more information on STS-133, visit www.nasa.gov/mission_pages/shuttle/shuttlemissions/sts133/. Photo credit: NASA/Frank Michaux

KSC-2010-5906

NASA Image and Video Library

2010-12-21

CAPE CANAVERAL, Fla. -- Space shuttle Discovery awaits its move, called rollback, from Launch Pad 39A to the Vehicle Assembly Building (VAB) at NASA's Kennedy Space Center in Florida. Rollback was scheduled for 12:30 a.m., but was postponed until 10 p.m. so technicians could resolve an issue with a leveling system on the crawler-transporter, which is to the left of the shuttle. Once inside the VAB, Discovery's external fuel tank will be examined and foam reapplied where 89 sensors were installed on the tank's aluminum skin for an instrumented tanking test on Dec. 17. The sensors were used to measure changes in the tank as super-cold propellants were pumped in and drained out. Data and analysis from the test will be used to determine what caused the tops of two, 21-foot-long support beams, called stringers, on the outside of the intertank to crack during fueling on Nov. 5. Discovery's next launch opportunity to the International Space Station on the STS-133 mission is no earlier than Feb. 3, 2011. For more information on STS-133, visit www.nasa.gov/mission_pages/shuttle/shuttlemissions/sts133/. Photo credit: NASA/Frank Michaux

KSC-2010-5908

NASA Image and Video Library

2010-12-21

CAPE CANAVERAL, Fla. -- Space shuttle Discovery awaits its move, called rollback, from Launch Pad 39A to the Vehicle Assembly Building (VAB) at NASA's Kennedy Space Center in Florida. Rollback was scheduled for 12:30 a.m., but was postponed until 10 p.m. so technicians could resolve an issue with a leveling system on the crawler-transporter, which is to the left of the shuttle. Once inside the VAB, Discovery's external fuel tank will be examined and foam reapplied where 89 sensors were installed on the tank's aluminum skin for an instrumented tanking test on Dec. 17. The sensors were used to measure changes in the tank as super-cold propellants were pumped in and drained out. Data and analysis from the test will be used to determine what caused the tops of two, 21-foot-long support beams, called stringers, on the outside of the intertank to crack during fueling on Nov. 5. Discovery's next launch opportunity to the International Space Station on the STS-133 mission is no earlier than Feb. 3, 2011. For more information on STS-133, visit www.nasa.gov/mission_pages/shuttle/shuttlemissions/sts133/. Photo credit: NASA/Frank Michaux

Launch Pad 39 Hail Monitor Array System

NASA Technical Reports Server (NTRS)

2008-01-01

Weather conditions at Kennedy Space Center are extremely dynamic, and they greatly affect the safety of the Space Shuttles sitting on the launch pads. For example, on May 13, 1999, the foam on the External Tank (ET) of STS-96 was significantly damaged by hail at the launch pad, requiring rollback to the Vehicle Assembly Building. The loss of ET foam on STS-114 in 2005 intensified interest in monitoring and measuring damage to ET foam, especially from hail. But hail can be difficult to detect and monitor because it is often localized and obscured by heavy rain. Furthermore, the hot Florida climate usually melts the hail even before the rainfall subsides. In response, the hail monitor array (HMA) system, a joint effort of the Applied Physics Laboratory operated by NASA and ASRC Aerospace at KSC, was deployed for operational testing in the fall of 2006. Volunteers from the Community Collaborative Rain, Hail, and Snow (CoCoRaHS) network, in conjunction with Colorado State University, continue to test duplicate hail monitor systems deployed in the high plains of Colorado.

Object Orientated Simulation on Transputer Arrays Using Time Warp

DTIC Science & Technology

1989-12-01

Transputer based Machines, Grenoble, Sept 14-16 1987, Ed. Traian Muntean. [ 3 ] Muntean T., "PARX operating system kernal; application to Minix ", Esprit P1085...Simulation 3 Time Warp Simulation 8 3.1 Rollback Mechanism ........ ............................. 8 3.2 Simulation Outp,,t...23 4.3.* Importan Noc .......... ............................ 23 5 Low Level Operations 24 • 3 IIiI 5.1 Global Virtual Timne Estimiation

[Theories of stages of life within the anthropology of romanticism].

PubMed

Schweizer, Pia-Johanna; Schweizer, Stefan

2006-12-01

The essay discusses the importance and prominence of theories about different stages of life in the anthropological and medical discourse of romanticism. This discourse has clearly a stabilising and restaurative function, favouring the age of moderate manhood. The political and social regulative implications of these theories demand a restaurative roll-back. The essay is based on a concept of sociology of knowledge formation.

Modeling the role of back-arc spreading in controlling 3-D circulation and temperature patterns in subduction zones

NASA Astrophysics Data System (ADS)

Kincaid, C.

2005-12-01

Subduction of oceanic lithosphere provides a dominant driving force for mantle dynamics and plate tectonics, and strongly modulates the thermal evolution of the mantle. Magma generation in arc environments is related to slab temperatures, slab dehydration/wedge hydration processes and circulation patterns in the mantle wedge. A series of laboratory experiments is used to model three-dimensional aspects of flow in subduction zones, and the consequent temperature variations in the slab and overlying mantle wedge. The experiments utilize a tank of glucose syrup to simulate the mantle and a Phenolic plate to represent subducting oceanic lithosphere. Different modes of plate sinking are produced using hydraulic pistons. The effects of longitudinal, rollback and slab-steepening components of slab motions are considered, along with different thicknesses of the over-riding lithosphere. Models look specifically at how distinct modes of back-arc spreading alter subduction zone temperatures and flow in the mantle wedge. Results show remarkably different temperature and circulation patterns when spreading is produced by rollback of the trench-slab-arc relative to a stationary overriding back-arc plate versus spreading due to motion of the overriding plate away from a fixed trench location. For rollback-induced spreading, flow trajectories in the wedge are shallow (e.g., limited upwelling), both the sub-arc and back-arc regions are supplied by material flowing around the receding slab. Flow lines in the sub-arc wedge are strongly trench-parallel. In these cases, strong lateral variations in slab surface temperature (SST) are recorded (hot at plate center, cool at plate edge). When the trench is fixed in space and spreading is produced by motion of the overriding plate, strong vertical flow velocities are recorded in the wedge, both the shallow sub-arc and back-arc regions are supplied by flow from under the overriding plate producing strong vertical shear. In these cases SSTs are nearly uniform across the plate. Results have implications for geochemical and seismic models of 3-D flow in subduction zones influenced by back-arc spreading, such as the Marianas.

Relation of local scour to hydraulic properties at selected bridges in New York

USGS Publications Warehouse

Butch, Gerard K.; ,

1993-01-01

Hydraulic properties, bridge geometry, and basin characteristics at 31 bridges in New York are being investigated to identify factors that affect local scour. Streambed elevations measured by the U.S. Geological Survey and New York State Department of Transportation are used to estimate local-scour depth. Data that show zero or minor scour were included in the analysis to decrease bias and to estimate hydraulic properties related to local scour. The maximum measured local scour at the 31 bridges for a single peak flow was 5.4 feet, but the deepening of scour holes at two sites to 6.1 feet and 7.8 feet by multiple peak flows could indicate that the number or duration of high flows is a factor. Local scour at a pier generally increased as the recurrence interval (magnitude) of the discharge increased, but the correlation between local-scour depth and recurrence interval was inconsistent among study sites. For example, flows with a 2-year recurrence interval produced 2 feet of local scour at two sites, whereas a flow with a recurrence interval produced 2 feet of local scour at two sites, whereas a flow with a recurrence interval of 50 years produced only 0.5 feet of local scour at another site. Local-scour depth increased with water depth, stream velocity, and Reynolds number but did not correlate well with bed-material size, Froude number, pier geometry, friction slope, or several other hydraulic and basin characteristics.

The Collapse and Spreading of Sundaland (SE Asia); evolution and Boundary Conditions

NASA Astrophysics Data System (ADS)

Pubellier, Manuel; Morley, Christopher

2014-05-01

By the end of Mesozoic times Sundaland (the continental core of SE Asia) was an elevated area composed of granite and metamorphic basement on the rims; which suffered collapse and incipient extension, whereas the central part was stable. Most of the basins opened inside evolved since the Late Cretaceous in a manner that may be correlated to the conditions of the subduction in the Sunda Trench. The Sundaland promontory was surrounded by a large subduction zone, except in the north and was a free boundary in the Early Cenozoic. Starting from the Palaeogene, fractures initiated during the India Eurasia collision, and rifting began along large faults (mostly N-S and NNW-SSE strike-slip). The basins remained in a continental fluvio-lacustrine or shallow marine environment for a long time and some are marked by extremely stretched crust (Phu Khanh, Natuna, N. Makassar) or even reached the ocean floor spreading stage (Celebes, Flores). Western Sundaland was a combination of basin opening and strike-slip transpressional deformation. The configuration suggests a free boundary particularly to the east (trench pull associated with the Proto-South China Sea subduction; Java-Sulawesi trench subduction rollback). In the Early Miocene, Australian blocks reached the Sunda subduction zone and imposed local shortening in the south and southeast, whereas the western part was free from compression after the Indian continent had moved away to the north. This suggests an important coupling of the Sunda Plate with the Indo-Australian Plate both to SE and NW, possibly further west rollback had ceased in the Java-Sumatra subduction zone, and compressional stress was being transferred northwards across the plate boundary. The internal compression is expressed to the south by shortening which is transmitted as far as the Malay basin. In the Late Miocene, most of the Sunda Plate was under compression, except the tectonically isolated Andaman Sea and the Damar basins. In the Pliocene, collision north of Australia propagated toward the north and west causing subduction reversal and compression in the short-lived Damar Basin. Docking of the Philippine Plate confined the eastern side of Sundaland and created local compression and uplift such as in NW Borneo, Palawan and Taiwan. Transpressional deformation created extensive folding, strike-slip faulting and uplift of the Central Basin and Arakan Yoma in Myanmar. Minor inversion affected many Thailand rift basins. All the other basins record subsidence. The uplift is responsible for gravity tectonics where thick sediments were accumulated (Sarawak, NE Luconia, Bangladesh wedge). We conclude that the evolution of the basin is closely controlled by the absence or the arrival of continental crust at the boundary of Sundaland.

Time Warp Operating System, Version 2.5.1

NASA Technical Reports Server (NTRS)

Bellenot, Steven F.; Gieselman, John S.; Hawley, Lawrence R.; Peterson, Judy; Presley, Matthew T.; Reiher, Peter L.; Springer, Paul L.; Tupman, John R.; Wedel, John J., Jr.; Wieland, Frederick P.;

A cache-aided multiprocessor rollback recovery scheme

NASA Technical Reports Server (NTRS)

Wu, Kun-Lung; Fuchs, W. Kent

1989-01-01

This paper demonstrates how previous uniprocessor cache-aided recovery schemes can be applied to multiprocessor architectures, for recovering from transient processor failures, utilizing private caches and a global shared memory. As with cache-aided uniprocessor recovery, the multiprocessor cache-aided recovery scheme of this paper can be easily integrated into standard bus-based snoopy cache coherence protocols. A consistent shared memory state is maintained without the necessity of global check-pointing.

Out of (South) Africa: Pretoria`s nuclear weapons experience. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Horton, R.E.

1998-04-01

The primary focus of this paper is the impact of key South African leaders on the successful developments and subsequent rollbacks of South Africa`s nuclear weapons capability. It highlights the key milestones in the development of South Africa`s nuclear weapon capability. It also relates how different groups within South Africa (scientists, politicians, military and technocrats) interacted to successfully produce South Africa`s nuclear deterrent. It emphasizes the pivotal influence of the senior political leadership to pursue nuclear rollback given the disadvantages of its nuclear means to achieve vital national interests. The conclusions drawn from flu`s effort are the South African nuclearmore » program was an extreme response to its own identity Crisis. Nuclear weapons became a means to achieving a long term end of a closer affiliation with the West. A South Africa yearning to be identified as a Western nation and receive guarantees of its security rationalized the need for a nuclear deterrent. The deterrent was intended to draw in Western support to counter a feared total onslaught by Communist forces in the region. Two decades later, that same South Africa relinquished its nuclear deterrent and reformed its domestic policies to secure improved economic and political integration with the West.« less

Can in vitro systems capture the characteristic differences between the flexion-extension kinematics of the healthy and TKA knee?

PubMed

Varadarajan, Kartik M; Harry, Rubash E; Johnson, Todd; Li, Guoan

2009-10-01

In vitro systems provide a powerful means to evaluate the efficacy of total knee arthroplasty (TKA) in restoring normal knee kinematics. The Oxford knee rig (OKR) and the robotic knee testing system (RKTS) represent two systems that have been extensively used to study TKA biomechanics. Nonetheless, a frequently asked question is whether in vitro simulations can capture the in vivo behavior of the knee. Here, we compared the flexion-extension kinematics of intact knees and knees after TKA tested on the OKR and RKTS, to results of representative in vivo studies. The goal was to determine if the in vitro systems could capture the key kinematic features of knees in healthy subjects and TKA patients. Results showed that the RKTS and the OKR can replicate the femoral rollback and 'screw home' tibial rotation between 0 degrees and 30 degrees flexion seen in healthy subjects, and the reduced femoral rollback and absence of 'screw home' motion in TKA patients. The RKTS also replicated the overall internally rotated position of the tibia beyond 30 degrees flexion. However, ability of the OKR to replicate the internally rotated position of the knee beyond 30 degrees flexion was inconsistent. These data could aid in validation of new in vitro systems and physiologic interpretations of in vitro results.

Evaluation of locally established reference intervals for hematology and biochemistry parameters in Western Kenya.

PubMed

Odhiambo, Collins; Oyaro, Boaz; Odipo, Richard; Otieno, Fredrick; Alemnji, George; Williamson, John; Zeh, Clement

2015-01-01

Important differences have been demonstrated in laboratory parameters from healthy persons in different geographical regions and populations, mostly driven by a combination of genetic, demographic, nutritional, and environmental factors. Despite this, European and North American derived laboratory reference intervals are used in African countries for patient management, clinical trial eligibility, and toxicity determination; which can result in misclassification of healthy persons as having laboratory abnormalities. An observational prospective cohort study known as the Kisumu Incidence Cohort Study (KICoS) was conducted to estimate the incidence of HIV seroconversion and identify determinants of successful recruitment and retention in preparation for an HIV vaccine/prevention trial among young adults and adolescents in western Kenya. Laboratory values generated from the KICoS were compared to published region-specific reference intervals and the 2004 NIH DAIDS toxicity tables used for the trial. About 1106 participants were screened for the KICoS between January 2007 and June 2010. Nine hundred and fifty-three participants aged 16 to 34 years, HIV-seronegative, clinically healthy, and non-pregnant were selected for this analysis. Median and 95% reference intervals were calculated for hematological and biochemistry parameters. When compared with both published region-specific reference values and the 2004 NIH DAIDS toxicity table, it was shown that the use of locally established reference intervals would have resulted in fewer participants classified as having abnormal hematological or biochemistry values compared to US derived reference intervals from DAIDS (10% classified as abnormal by local parameters vs. >40% by US DAIDS). Blood urea nitrogen was most often out of range if US based intervals were used: <10% abnormal by local intervals compared to >83% by US based reference intervals. Differences in reference intervals for hematological and biochemical parameters between western and African populations highlight importance of developing local reference intervals for clinical care and trials in Africa.

Plumes do not Exist: Plate Circulation is Confined to Upper Mantle

NASA Astrophysics Data System (ADS)

Hamilton, W. B.

2002-12-01

Plumes from deep mantle are widely conjectured to define an absolute reference frame, inaugurate rifting, drive plates, and profoundly modify oceans and continents. Mantle properties and composition are assumed to be whatever enables plumes. Nevertheless, purported critical evidence for plume speculation is false, and all data are better interpreted without plumes. Plume fantasies are made ever more complex and ad hoc to evade contradictory data, and have no predictive value because plumes do not exist. All plume conjecture derives from Hawaii and the guess that the Emperor-Hawaii inflection records a 60-degree change in Pacific plate direction at 45 Ma. Paleomagnetic latitudes and smooth Pacific spreading patterns disprove any such change. Rationales for other fixed plumes collapse when tested, and hypotheses of jumping, splitting, and gyrating plumes are specious. Thermal and physical properties of Hawaiian lithosphere falsify plume predictions. Purported tomographic support elsewhere represents artifacts and misleading presentations. Asthenosphere is everywhere near solidus temperature, so melt needs a tensional setting for egress but not local heat. Gradational and inconsistent contrasts between MORB and OIB are as required by depth-varying melt generation and behavior in contrasted settings and do not indicate systematically unlike sources. MORB melts rise, with minimal reaction, through hot asthenosphere, whereas OIB melts react with cool lithosphere, and lose mass, by crystallizing refractories and retaining and assimilating fusibles. The unfractionated lower mantle of plume conjecture is contrary to cosmologic and thermodynamic data, for mantle below 660 km is more refractory than that above. Subduction, due to density inversion by top-down cooling that forms oceanic lithosphere, drives plate tectonics and upper-mantle circulation. It organizes plate motions and lithosphere stress, which controls plate boundaries and volcanic chains. Hinge rollback is the key to kinematics. Arcs advance and collide, fast-spreading Pacific shrinks, etc. A fore-arc basin atop an overriding plate shows that hinge and non-shortening plate front there track together: velocities of rollback and advance are equal. Convergence velocity commonly also equals rollback velocity but often is greater. Slabs sinking broadside push upper mantle back under incoming plates and force rapid Pacific spreading, whereas overriding plates flow forward with retreating hinges. Backarc basins open behind island arcs migrating with hinges. Slabs settle on uncrossable 660-km discontinuity. (Contrary tomographic claims reflect sampling and smearing artifacts, notably due to along-slab raypaths.) Plates advance over sunken slabs and mantle displaced rearward by them, and ridges spread where advancing plates pull away. Ridges migrate over asthenosphere, producing geophysical and bathymetric asymmetry, and tap fresh asthenosphere into which slab material is recycled upward. Sluggish deep-mantle circulation is decoupled from rapid upper-mantle circulation, so plate motions can be referenced to semistable lower mantle. Global plate motions make kinematic sense if Antarctica, almost ringed by departing ridges and varying little in Cenozoic paleomagnetic position, is stationary: hinges roll back, ridges migrate, and directions and velocities of plate rotations accord with subduction, including sliding and crowding of oceanic lithosphere toward free edges, as the dominant drive. (The invalid hotspot and no-net-rotation frames minimize motions of hinges and ridges, and their plate motions lack kinematic sense.) Northern Eurasia also is almost stationary, Africa rotates very slowly counterclockwise toward Aegean and Zagros, Pacific plate races toward surface-exit subduction systems, etc.

On the local fractional derivative of everywhere non-differentiable continuous functions on intervals

NASA Astrophysics Data System (ADS)

Liu, Cheng-shi

2017-01-01

We first prove that for a continuous function f(x) defined on an open interval, the Kolvankar-Gangal's (or equivalently Chen-Yan-Zhang's) local fractional derivative f(α)(x) is not continuous, and then prove that it is impossible that the KG derivative f(α)(x) exists everywhere on the interval and satisfies f(α)(x) ≠ 0 in the same time. In addition, we give a criterion of the nonexistence of the local fractional derivative of everywhere non-differentiable continuous functions. Furthermore, we construct two simple nowhere differentiable continuous functions on (0, 1) and prove that they have no the local fractional derivatives everywhere.

A Survey of Rollback-Recovery Protocols in Message-Passing Systems

DTIC Science & Technology

1999-06-01

and M.A. Castillo. "Checkpointing through garbage collection." Technical report. Departamento de Ciencia de la Computation, Escuela de Ingenieria ...between consecutive checkpoints. It can be implemented by using the dirty-bit of the memory protection hardware or by emulating a dirty-bit in software [4...compare the program’s state with the previous checkpoint in software , and writing the difference in a new checkpoint [46]. The required storage and

Calcareous nannoplankton and foraminiferal response to global Oligocene and Miocene climatic oscillations: a case study from the Western Carpathian segment of the Central Paratethys

NASA Astrophysics Data System (ADS)

Holcová, Katarína

2017-06-01

The reactions of foraminiferal and calcareous nannoplankton assemblages to global warming and cooling events in the time intervals of ca. 27 to 19 Ma and 13.5 to 15 Ma (Oligocene and Miocene) were studied in subtropical epicontinental seas influenced by local tectonic and palaeogeographic events (the Central Paratethys). Regardless of these local events, global climatic processes significantly influenced the palaeoenvironment within the marine basin. Warm intervals are characterized by a stable, humid climate and a high-nutrient regime, due primarily to increased continental input of phytodetritus and also locally due to seasonal upwelling. Coarse clastics deposited in a hyposaline environment characterize the marginal part of the basin. Aridification events causing decreased riverine input and consequent nutrient decreases, characterized cold intervals. Apparent seasonality, as well as catastrophic climatic events, induced stress conditions and the expansion of opportunistic taxa. Carbonate production and hypersaline facies characterize the marginal part of the basins. Hypersaline surface water triggered downwelling circulation and mixing of water masses. Decreased abundance or extinction of K-specialists during each cold interval accelerated their speciation in the subsequent warm interval. Local tectonic events led to discordances between local and global sea-level changes (tectonically triggered uplift or subsidence) or to local salt formation (in the rain shadows of newly-created mountains).

Impact Upon California School Districts of Senate Bill 90 of 1972 and Assembly Bill 1267 of 1973. A Report to the California Legislature as Required by Assembly Concurrent Resolution No. 54.

ERIC Educational Resources Information Center

California State Dept. of Education, Sacramento. Bureau of School Apportionments and Reports.

This report analyzes the impact of California's 1972 Senate Bill 90 and 1973 Assembly Bill 1267 as they have affected public school finance in California. The portions of SB 90 and AB 1267 that pertain to operating school districts contain general property tax rollback and revenue limit features, as well as mechanisms designed to lessen the…

KSC-03pd0077

NASA Image and Video Library

2003-01-15

KENNEDY SPACE CENTER, FLA. -- The late afternoon sun highlights the external tank and solid rocket booster on Space Shuttle Columbia after rollback of the Rotating Service Structure on Launch Pad 39A. Visible are the orbiter access arm with the White Room extended to Columbia's cockpit, and at the top, the gaseous oxygen vent arm and cap, called the "beanie cap." Columbia is scheduled for launch Jan. 16 at 10:39 a.m. EST on mission STS-107, a research mission.

KSC-03pd0074

NASA Image and Video Library

2003-01-15

KENNEDY SPACE CENTER, FLA. -- The late afternoon sun highlights the external tank and solid rocket booster on Space Shuttle Columbia after rollback of the Rotating Service Structure on Launch Pad 39A. Visible are the orbiter access arm with the White Room extended to Columbia's cockpit, and at the top, the gaseous oxygen vent arm and cap, called the "beanie cap." Columbia is scheduled for launch Jan. 16 at 10:39 a.m. EST on mission STS-107, a research mission.

Orbiting Carbon Observatory-2 (OCO-2)

NASA Image and Video Library

2014-06-30

Workers monitor the progress of the rollback of the launch gantry from the United Launch Alliance Delta II rocket with the Orbiting Carbon Observatory-2 (OCO-2) satellite onboard, at Space Launch Complex 2, Monday, June 30, 2014, Vandenberg Air Force Base, Calif. OCO-2 will measure the global distribution of carbon dioxide, the leading human-produced greenhouse gas driving changes in Earth’s climate. OCO-2 is set for a July 1, 2014 launch. Photo Credit: (NASA/Bill Ingalls)

Thinking About the Unthinkable: Tokyo’s Nuclear Option

DTIC Science & Technology

2009-01-01

Sagan. Sounding a Thucydidean note, he maintains that “strong states do what they can . . . adopting the costly, but self-sufficient, policy of developing...arsenal within a reasonable amount of time. This is not an uncommon approach for governments. Notes Ariel Levite , “Would-be proliferants rarely make...low.26 More to the point, Levite defines “‘nuclear hedging’ as a national strat- egy lying between nuclear pursuit and nuclear rollback.”27 John F

Intraoperative evaluation of total knee replacement: kinematic assessment with a navigation system.

PubMed

Casino, Daniela; Zaffagnini, Stefano; Martelli, Sandra; Lopomo, Nicola; Bignozzi, Simone; Iacono, Francesco; Russo, Alessandro; Marcacci, Maurilio

2009-04-01

Interest in the kinematics of reconstructed knees has increased since it was shown that the alteration of knee motion could lead to abnormal wear and damage to soft tissues. We performed intraoperative kinematic measurements using a navigation system to study knee kinematics before and after posterior substituting rotating platform total knee arthroplasty (TKA). We verified intraoperatively (1) if varus/valgus (VV) laxity and anterior/posterior (AP) laxity were restored after TKA; (2) if TKA induced abnormal femoral rollback; and (3) how tibial axial rotation was influenced by TKA throughout the range of flexion. We found that TKA improved alignment in preoperative osteoarthritic varus knees which became neutral after surgery and maintained a neutral alignment in neutral knees. The VV stability at 0 degrees was restored while AP laxity at 90 degrees significantly increased after TKA. Following TKA, the femur had an abnormal anterior translation up to 60 degrees of flexion, followed by a small rollback of 12 +/- 5 mm. TKA influenced the tibia rotation pattern during flexion, but not the total amount of internal/external rotation throughout whole range of flexion, which was preserved after TKA (6 degrees +/- 5 degrees ). This study showed that the protocol proposed might be useful to adjust knee stability at time zero and that knee kinematic outcome during total knee replacement can be monitored by a navigation system.

Large-Scale Crustal-Block-Extrusion During Late Alpine Collision.

PubMed

Herwegh, Marco; Berger, Alfons; Baumberger, Roland; Wehrens, Philip; Kissling, Edi

2017-03-24

The crustal-scale geometry of the European Alps has been explained by a classical subduction-scenario comprising thrust-and-fold-related compressional wedge tectonics and isostatic rebound. However, massive blocks of crystalline basement (External Crystalline Massifs) vertically disrupt the upper-crustal wedge. In the case of the Aar massif, top basement vertically rises for >12 km and peak metamorphic temperatures increase along an orogen-perpendicular direction from 250 °C-450 °C over horizontal distances of only <15 km (Innertkirchen-Grimselpass), suggesting exhumation of midcrustal rocks with increasing uplift component along steep vertical shear zones. Here we demonstrate that delamination of European lower crust during lithosphere mantle rollback migrates northward in time. Simultaneously, the Aar massif as giant upper crustal block extrudes by buoyancy forces, while substantial volumes of lower crust accumulate underneath. Buoyancy-driven deformation generates dense networks of steep reverse faults as major structures interconnected by secondary branches with normal fault component, dissecting the entire crust up to the surface. Owing to rollback fading, the component of vertical motion reduces and is replaced by a late stage of orogenic compression as manifest by north-directed thrusting. Buoyancy-driven vertical tectonics and modest late shortening, combined with surface erosion, result in typical topographic and metamorphic gradients, which might represent general indicators for final stages of continent-continent collisions.

Slab roll-back and trench retreat as controlling factor for basin subsidence in southern Central America

NASA Astrophysics Data System (ADS)

Brandes, Christian; Winsemann, Jutta

2015-04-01

Slab roll-back and trench retreat are important factors for basin subsidence, magma generation and volcanism in arc-trench systems. Based on the sedimentary and tectonic record of the southern Central American island-arc we conclude that repeated phases of slab roll-back and trench retreats occurred the arc-trench system since the Late Cretaceous. These trench retreats were most probably related to the subduction of oceanic plateaus and seamounts and effected both the fore-arc and back-arc evolution. We used numerical basin modelling techniques to analyse the burial history of fore-arc and back-arc basins in Central America and combined the results with field data of the sedimentological evolution of the basin-fills. From the basin models, geohistory curves were extracted for the fore-arc and back-arc basins to derive the subsidence evolution. The Sandino Fore-arc Basin is characterized by low subsidence during the first 40 Myr. Since the Late Cretaceous the basin has a linear moderate subsidence with a phase of accelerated subsidence in the Oligocene. In the North and South Limón Back-arc Basin, subsidence started at approximately the same time as in the Sandino Fore-arc Basin. The North and South Limón Basins show a linear subsidence trend in the Paleocene and Eocene. Evidence for trench retreats is given by pulses of uplift in the outer-arc area, followed by subsidence in both the fore-arc and back-arc basins. The first slab roll-back probably occurred during the Early Paleocene. This is indicated by the collapse of carbonate platforms, and the re-deposition of large carbonate blocks into deep-water turbidites. A new pulse of uplift or decreased subsidence, respectively during the Late Eocene is attributed to subduction of rough crust. A subsequent slab detachment and the establishment of a new subduction zone further westward was described by Walther et al. (2000). Strong uplift affected the entire fore-arc area, which led to the deposition of very coarse-grained deepwater channel-levee complexes in the Sandino Fore-arc Basin. The channel-fills are rich in reworked shallow-water carbonates that points to strong uplift of the inner fore-arc. A subsequent trench retreat is indicated by an increased subsidence during the Early Oligocene in the Sandino Fore-arc Basin and the collapse of the Barra Honda carbonate platform in North Costa Rica. Another trench retreat might have occurred in Miocene times (Cailleau and Oncken, 2008). A phase of higher subsidence from 18 to 13 Ma is documented in the geohistory curve of the North Limon Back-arc Basin. After a short pulse of uplift the subsidence increased to approx. 300 m/myr (Brandes et al., 2008). References: Brandes C., Astorga A., Littke R. and Winsemann J. (2008) Basin modelling of the Limón Back-arc Basin (Costa Rica): burial history and temperature evolution of an island-arc related basin system. Basin Research 20, 1, 119-142. Cailleau, B. and Oncken, O. (2008) Past forearc deformation in Nicaragua and coupling at the megathrust interface: Evidence for subduction retreat. Geochemistry, Geophysics, Geosystems 9, Q07S24, doi:10.1029/2007GC001754. Walther, C.H.E., Flueh, E.R., Ranero, C.R., von Huene, R. and Strauch, W. (2000) Crustal structure across the Pacific margin of Nicaragua: evidence for ophiolithic basement and a shallow mantle sliver. Geophysical Journal International 141, 759-777.

Zircon Lu-Hf isotope systematics and U-Pb geochronology, whole-rock Sr-Nd isotopes and geochemistry of the early Jurassic Gokcedere pluton, Sakarya Zone-NE Turkey: a magmatic response to roll-back of the Paleo-Tethyan oceanic lithosphere

NASA Astrophysics Data System (ADS)

Karsli, Orhan; Dokuz, Abdurrahman; Kandemir, Raif

2017-05-01

The early Mesozoic was a critical era for the geodynamic evolution of the Sakarya Zone as transition from accretion to collision events in the region. However, its complex evolutionary history is still debated. To address this issue, we present new in situ zircon U-Pb ages and Lu-Hf isotope data, whole-rock Sr-Nd isotopes, and mineral chemistry and geochemistry data of plutonic rocks to better understand the magmatic processes. The Gokcedere pluton is mainly composed of gabbro and gabbroic diorite. LA-ICP-MS zircon U-Pb dating reveals that the pluton was emplaced in the early Jurassic (177 Ma). These gabbros and gabbroic diorites are characterized by relatively low SiO2 content of 47.09 to 57.15 wt% and high Mg# values varying from 46 to 75. The samples belong to the calc-alkaline series and exhibit a metaluminous I-type character. Moreover, they are slightly enriched in large ion lithophile elements (Rb, Ba, Th and K) and light rare earth elements and depleted in high field strength elements (Nb and Ti). Gabbroic rocks of the pluton have a depleted Sr-Nd isotopic composition, including low initial 87Sr/86Sr ranging from 0.705124 to 0.705599, relatively high ɛ Nd ( t) values varying from 0.1 to 3.5 and single-stage Nd model ages ( T DM1 = 0.65-0.95 Ga). In situ zircon analyses show that the rocks have variable and positive ɛ Hf ( t) values (4.6 to 13.5) and single-stage Hf model ages ( T DM1 = 0.30 to 0.65 Ga). Both the geochemical signature and Sr-Nd-Hf isotopic composition of the gabbroic rocks reveal that the magma of the studied rocks was formed by the partial melting of a depleted mantle wedge metasomatized by slab-derived fluids. The influence of slab fluids is mirrored by their trace-element characteristics. Trace-element modeling suggests that the primary magma was generated by a low and variable degree of partial melting ( 5-15%) of a depleted and young lithospheric mantle wedge consisting of phlogopite- and spinel-bearing lherzolite. Heat to melt the mantle material was supplied by the ascendance of a hot asthenosphere triggered by the roll-back of the Paleo-Tethyan oceanic lithosphere. The rising melts were accompanied by fractional crystallization and encountered no or minor crustal contamination en route to the surface. Taking into account these geochemical data and integrating them with regional geological evidence, we propose a slab roll-back model; this model suggests that the Gokcedere gabbroic pluton originated in a back-arc extensional environment associated with the southward subduction of the Paleo-Tethyan oceanic lithosphere during the early Jurassic period. Such an extensional event led to the opening of the northern branch of the Neotethys as a back-arc basin. Consequently, we conclude that the gabbroic pluton was related to intensive extensional tectonic events, which peaked during the early Jurassic in response to the roll-back of Paleo-Tethyan oceanic slab in the final stage of oceanic closure.

Latest Cretaceous "A2-type" granites in the Sakarya Zone, NE Turkey: Partial melting of mafic lower crust in response to roll-back of Neo-Tethyan oceanic lithosphere

NASA Astrophysics Data System (ADS)

Karsli, Orhan; Aydin, Faruk; Uysal, Ibrahim; Dokuz, Abdurrahman; Kumral, Mustafa; Kandemir, Raif; Budakoglu, Murat; Ketenci, Murat

2018-03-01

An integrated study of comprehensive geochronological, geochemical, and Sr-Nd-Hf isotopic data was undertaken for the A-type Topcam pluton that intruded within the Sakarya Zone (NE Turkey) with the aims of elucidating its origin and tectonic significance and gaining new insights into the generation of aluminous A-type granites. New LA-ICP-MS zircon U-Pb crystallization ages of 72 and 73 Ma indicate emplacement in the Late Cretaceous time, just after extensive metaluminous I-type magmatism in the area. The pluton consists mainly of alkali feldspar, quartz, plagioclase, amphibole, and biotite with accessory minerals such as magnetite, apatite, and zircon. The outcrop is composed of granite, syenite, monzonite, and quartz monzonite and possesses a wide range of SiO2 content (57-70 wt%) with elevated Ga/Al ratios and low Mg# (mostly < 43). The pluton is metaluminous to weakly peraluminous, with aluminium saturation index (ASI) (molar Al2O3/[CaO + K2O + Na2O]) values of 0.82 to 1.18, and belongs to the shoshonitic and ultra-potassic series. All the samples exhibit relative enrichment in light rare earth elements (LREE) and significant negative Eu (Eu/Eu* = 0.31 to 0.86) anomalies on the chondrite-normalized REE diagram. The rocks are enriched in some large ion lithophile elements (e.g., Rb, Th and Ba), and spidergrams show a relative depletion in Nb, Ti, and Sr. The granitic rocks of the pluton have identical 87Sr/86Sr(i) ratios ranging from 0.70518 to 0.70716, relatively low εNd (t) values varying from - 5.5 to - 0.4, and TDM ages (0.82-1.19 Ga). In situ zircon analyses show that the rocks have variable negative and positive εHf (t) values (- 5.5 to 5.9) and Hf two-stage model ages (742 to 1468 Ma), which are indicative of minor addition of juvenile material. Sr-Nd isotope modelling suggests mixing of 70-90% of lower crustal-derived melt with 10-30% of mantle-derived melt at lower crust depths. The heat source for partial melting is provided by upwelling of hot asthenosphere triggered by slab roll-back events. Geochemical and isotopic data reveal that metaluminous A2-type granites were derived from partial melting of the Paleozoic lower continental crust dominated by mafic rocks in amphibolitic composition, with minor input of subcontinental lithospheric mantle-derived magma followed by subsequent limited fractional crystallization to generate a variety of rock types. From integrating all available data with the regional tectonic evolution in the Sakarya Zone and adjacent regions, we attribute generation of aluminous A2-type granites to a back-arc extension in the subduction zone, which is induced by the roll-back of the Neo-Tethyan oceanic slab around 72 Ma. Consequently, we conclude that these A-type granites were related to intensive extension tectonic, which peaked during the late Cretaceous (Maastrichtian) in response to the roll-back of the Neo-Tethyan oceanic slab, which is indicative of the final-stage subduction-related magmatism in the Sakarya Zone.

Extension Within The Australia-Eurasia Collision: The Metamorphic Rocks Of Central Sulawesi, Indonesia

NASA Astrophysics Data System (ADS)

Watkinson, I. M.; Hall, R.; Hennig, J.; Forster, M.

2012-12-01

Low-angle mylonitic fabrics from the metamorphic basement of central Sulawesi reveal a complex history of extension from the late Miocene to the present-day. Sulawesi is situated in the convergent triple junction between the Australian, Eurasian and Philippine Sea plates. The island is cut by the Palu-Koro and Matano faults, major active strike-slip zones that were initiated no earlier than about 5 Ma and have previously been attributed to collision-related processes. Within, and to the north and east of the strike-slip faults, are a suite of metamorphic complexes that include mica schists, schistose amphibolites, gneisses, migmatites, granulites, eclogites, marbles and ultramafic rocks including garnet peridotites. Mylonitic fabrics are widespread throughout the metamorphic rocks. The orientation of the mylonitic foliation is highly variable but typically dips less than 30°. Kinematic indicators record transport directions dominantly between top-to-the-NW and top-to-the-NE. Medium to high-grade mylonites, particularly in the south and west, are associated with ductile boudinage of eclogite and kyanite-bearing layers, 'snowball' garnet porphyroclasts, dynamic recrystallisation of feldspar and amphibole, and mylonitic deformation was locally synchronous with partial melting. Medium to high-grade mylonites are commonly overprinted by isoclinal asymmetric similar folds. Low grade mylonites are characterised by quartz recrystallisation only. Mica growth during mylonitic deformation is recorded by young 40Ar-39Ar plateaux between 5.05 ± 0.01 Ma and 2.07 ± 0.03 Ma in the west and 11.33 ± 0.02 Ma in the east. Undeformed aplitic dykes of similar composition to the migmatite leucosomes locally cross-cut the migmatitic mylonites and have yielded a biotite 40Ar-39Ar plateau of 3.62 ± 0.02 Ma. In the east the mylonitic fabric is cut by a low-angle detachment surface expressed as anomalously corrugated topography. On the basis of lithologic variation, shear-sense directions, 40Ar-39Ar ages and topographic character it is possible to divide the central Sulawesi metamorphic complexes into a series of low-angle ductile shear zones, cut by an upper brittle detachment in the east which may still be active. Uplift of the metamorphic rocks has been largely in response to sequential unroofing along these structures. The system is bounded in the west by the Palu-Koro Fault, which links to subduction beneath north Sulawesi, and which may flatten at depth into a basal detachment below central Sulawesi. Early extension is synchronous with spreading in the North Banda Sea, and may have been driven by east-directed rollback of the Banda Sea. Later extension (post-5 Ma) was driven by subduction rollback in the north, and much of the extensional deformation in central Sulawesi represents the crustal 'tear' marking the southern limit of the effects of northward extension.

The Rollback of South Africa’s Chemical and Biological Warfare Program

DTIC Science & Technology

2001-04-01

Weapons and on Their Destruction (the BWC). 1974-1975 —Détente“ between South Africa and Zambia leads to cease-fire and SAP withdrawal from Rhodesia...to UNITA and leads to isolation of South Africa in Angola. vii February 1976 Defense Minister P.W. Botha delivers a speech to the South African...1977, leading to a call for more effective crowd control CBW agents. 1976-1979 War in Rhodesia (Zimbabwe) intensifies and leads to accusations of

Fixing unfair advantages? Providers hope to see more transparency, networks with Medicare private fee-for-service plans in wake of veto override.

PubMed

Lubell, Jennifer

2008-07-21

The new Medicare law delivers a raft of changes. But physicians are cheering the loudest for the rollback of the 10.6% reimbursement cut and the revamping of Medicare Advantage. "It doesn't make any sense that these private plans are paid 17% more than traditional Medicare and don't have to share a dime with the hospitals or physicians," says Albert Fisk, left, a Washington state physician.

76 FR 79607 - Local Number Portability Porting Interval and Validation Requirements; Telephone Number Portability

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-22

... 11-1954] Local Number Portability Porting Interval and Validation Requirements; Telephone Number... information when the new service provider requests a CSR: any working telephone number associated with the...://www.fcc.gov/cgb/ecfs . For detailed instructions for submitting comments and additional information on...

The genesis of early Carboniferous adakitic rocks at the southern margin of the Alxa Block, North China

NASA Astrophysics Data System (ADS)

Xue, Shuo; Ling, Ming-Xing; Liu, Yu-Long; Zhang, Hong; Sun, Weidong

2017-05-01

Adakite is a highly debated petrologic term that was originally proposed to describe igneous rocks formed by slab melting. Subsequent studies reported other ways to generate adakitic signatures such as the melting of mafic lower continental crust and fractional crystallization of basaltic magma. We studied adakitic rocks from the Taohuala Mountain at the southern margin of the Alxa Block, North China. These rocks are characterized by high Sr concentrations (300-450 ppm), high Sr/Y (20-75 ppm) and (La/Yb)N (25-67 ppm) ratios, and low Y (< 18 ppm) and Yb (< 1.9 ppm) concentrations, which are typical of adakite. The distribution of these data on a Sr/Y versus (La/Yb)N discrimination diagram, combined with their high (87Sr/86Sr)i ratios (0.7113-0.7131) and low εNd(t) (- 15.8 to - 16.8) and εHf(t) (- 18 to - 10) values of zircon, indicates that the adakitic rocks formed by partial melting of thickened continental crust. U-Pb dating of zircons using LA-ICP-MS yields an early Carboniferous age of 330 ± 5 Ma. The ages and spatial distribution of magmatic rocks indicate that the Paleo-Asian oceanic crust subducted towards the Alxa Block in the late Paleozoic. Subsequently, northward slab rollback occurred during the Carboniferous. Therefore, we propose that the adakitic rocks from the Taohuala Mountain formed by partial melting of previously thickened lower continental crust, induced by the upwelling of asthenospheric mantle during slab rollback.

Geochronology of the late Pliocene to recent volcanic activity in the Payenia back-arc volcanic province, Mendoza Argentina

NASA Astrophysics Data System (ADS)

Gudnason, Jónas; Holm, Paul Martin; Søager, Nina; Llambías, Eduardo J.

2012-08-01

Eighteen samples originating from monogenetic cones and larger complexes in the back-arc Payenia volcanic province, in Mendoza Argentina, have been dated by the 40Ar/39Ar method. Groundmass and plagioclase separates give plateau ages, ranging from 20.7 ± 0.5 to 0.06 ± 0.02 Ma. Payenia has been divided into six subfields based on the new and literature radiometric ages: Payún Matrú, Río Colorado, Llancanelo, and Nevado volcanic fields, the Northern segment and the Andes retro-arc group. Fifteen samples are younger than 2.83 Ma and show correlation between geographic position and age. Eruption centres younger than 0.5 Ma are concentrated to the west of 69° W with few exceptions among new and literature data. This westward shift of activity supports the rollback theory for the subducting Nazca plate since the late Pliocene. Furthermore, a northward progression of volcanism on the San Rafael block from 2.8 Ma to around 0.5 Ma is recognized. We conclude that rollback was initiated in the southern part of Payenia in the early Pliocene and progressed >200 km northwards during the Pliocene-Pleistocene period creating conditions for hydrous magma generation beneath the eastern part of Payenia. The long lived activity of the Payún Matrú complex is ascribed to the presence of a thermal anomaly in the underlying asthenosphere which could be plume-like.

Active rollback in the Gibraltar Arc: Evidences from CGPS data in the western Betic Cordillera

NASA Astrophysics Data System (ADS)

Gonzalez-Castillo, L.; Galindo-Zaldivar, J.; de Lacy, M. C.; Borque, M. J.; Martinez-Moreno, F. J.; García-Armenteros, J. A.; Gil, A. J.

2015-11-01

The Gibraltar Arc, located in the western Mediterranean Sea, is an arcuate Alpine orogen formed by the Betic and Rif Cordilleras, separated by the Alboran Sea. New continuous GPS data (2008-2013) obtained in the Topo-Iberia stations of the western Betic Cordillera allow us to improve the present-day deformation pattern related to active tectonics in this collision area between the Eurasian and African plates. These data indicate a very consistent westward motion of the Betic Cordillera with respect to the relatively stable Iberian Massif foreland. The displacement in the Betics increases toward the south and west, reaching maximum values in the Gibraltar Strait area (4.27 mm/yr in Ceuta, CEU1, and 4.06 mm/yr in San Fernando, SFER), then progressively decreasing toward the northwestern mountain front. The recent geological structures and seismicity evidence moderate deformation in a roughly NW-SE to WNW-ESE compressional stress setting in the mountain frontal areas, and moderate extension toward the internal part of the cordillera. The mountain front undergoes progressive development of folds affecting at least up to Pliocene deposits, with similar recent geological and geodetical rates. This folded strip helps to accommodate the active deformation with scarce associated seismicity. The displacement pattern is in agreement with the present-day clockwise rotation of the tectonic units in the northern branch of the Gibraltar Arc. Our data support that the westward emplacement of the Betic Cordillera continues to be active in a rollback tectonic scenario.

Discontinuous Galerkin (DG) Method for solving time dependent convection-diffusion type temperature equation : Demonstration and Comparison with Other Methods in the Mantle Convection Code ASPECT

NASA Astrophysics Data System (ADS)

He, Y.; Puckett, E. G.; Billen, M. I.; Kellogg, L. H.

2016-12-01

For a convection-dominated system, like convection in the Earth's mantle, accurate modeling of the temperature field in terms of the interaction between convective and diffusive processes is one of the most common numerical challenges. In the geodynamics community using Finite Element Method (FEM) with artificial entropy viscosity is a popular approach to resolve this difficulty, but introduce numerical diffusion. The extra artificial viscosity added into the temperature system will not only oversmooth the temperature field where the convective process dominates, but also change the physical properties by increasing the local material conductivity, which will eventually change the local conservation of energy. Accurate modeling of temperature is especially important in the mantle, where material properties are strongly dependent on temperature. In subduction zones, for example, the rheology of the cold sinking slab depends nonlinearly on the temperature, and physical processes such as slab detachment, rollback, and melting all are sensitively dependent on temperature and rheology. Therefore methods that overly smooth the temperature may inaccurately represent the physical processes governing subduction, lithospheric instabilities, plume generation and other aspects of mantle convection. Here we present a method for modeling the temperature field in mantle dynamics simulations using a new solver implemented in the ASPECT software. The new solver for the temperature equation uses a Discontinuous Galerkin (DG) approach, which combines features of both finite element and finite volume methods, and is particularly suitable for problems satisfying the conservation law, and the solution has a large variation locally. Furthermore, we have applied a post-processing technique to insure that the solution satisfies a local discrete maximum principle in order to eliminate the overshoots and undershoots in the temperature locally. To demonstrate the capabilities of this new method we present benchmark results (e.g., falling sphere), and a simple subduction models with kinematic surface boundary condition. To evaluate the trade-offs in computational speed and solution accuracy we present results for the same benchmarks using the Finite Element entropy viscosity method available in ASPECT.

Efficient massively parallel simulation of dynamic channel assignment schemes for wireless cellular communications

NASA Technical Reports Server (NTRS)

Greenberg, Albert G.; Lubachevsky, Boris D.; Nicol, David M.; Wright, Paul E.

1994-01-01

Fast, efficient parallel algorithms are presented for discrete event simulations of dynamic channel assignment schemes for wireless cellular communication networks. The driving events are call arrivals and departures, in continuous time, to cells geographically distributed across the service area. A dynamic channel assignment scheme decides which call arrivals to accept, and which channels to allocate to the accepted calls, attempting to minimize call blocking while ensuring co-channel interference is tolerably low. Specifically, the scheme ensures that the same channel is used concurrently at different cells only if the pairwise distances between those cells are sufficiently large. Much of the complexity of the system comes from ensuring this separation. The network is modeled as a system of interacting continuous time automata, each corresponding to a cell. To simulate the model, conservative methods are used; i.e., methods in which no errors occur in the course of the simulation and so no rollback or relaxation is needed. Implemented on a 16K processor MasPar MP-1, an elegant and simple technique provides speedups of about 15 times over an optimized serial simulation running on a high speed workstation. A drawback of this technique, typical of conservative methods, is that processor utilization is rather low. To overcome this, new methods were developed that exploit slackness in event dependencies over short intervals of time, thereby raising the utilization to above 50 percent and the speedup over the optimized serial code to about 120 times.

The formation of the Late Cretaceous Xishan Sn-W deposit, South China: Geochronological and geochemical perspectives

NASA Astrophysics Data System (ADS)

Zhang, Lipeng; Zhang, Rongqing; Hu, Yongbin; Liang, Jinlong; Ouyang, Zhixia; He, Junjie; Chen, Yuxiao; Guo, Jia; Sun, Weidong

2017-10-01

The Xishan Sn-W deposit is spatially related to K-feldspar granites in the Yangchun basin, western Guangdong Province, South China. LA-ICP-MS zircon U-Pb dating for the Xishan pluton defines an emplacement age of 79 Ma (78.1 ± 0.9 Ma; 79.0 ± 1.2 Ma; 79.3 ± 0.8 Ma), consistent with the mineralization age of the Xishan Sn-W deposit constrained by molybdenite Re-Os isochron age (79.4 ± 4.5 Ma) and LA-ICP-MS cassiterite U-Pb ages (78.1 ± 0.9 Ma and 79.0 ± 1.2 Ma) for the cassiterite-quartz vein. These indicate a close genetic relationship between the granite and Sn-W mineralization. The Xishan K-feldspar granites have geochemical characteristics of A-type granites, e.g., high total alkali (Na2O + K2O = 7.88-10.07 wt.%), high Ga/Al ratios (10000*Ga/Al > 2.6) and high Zr + Nb + Ce + Y concentrations (> 350 ppm). They are further classified as A2-type granites. The whole-rock isotopic compositions of K-feldspar granites (initial 87Sr/86Sr = 0.705256-0.706181; εNd(t) = - 5.4 to - 4.8) and zircon εHf(t) values (- 7.8 to 2.0) suggest a mixed magma source. The low zircon Ce4 +/Ce3 + ratios (12-88) of K-feldspar granites suggest low oxygen fugacities, which is key for enrichment of tin in primary magmas. The K-feldspar granites have experienced strong differentiation as indicated by their high Rb/Sr and K/Rb ratios, and low Nb/Ta and Zr/Hf ratios, which play an important role in ore-forming element transportation and concentration. A-type granite characteristics of the Xishan pluton show that it formed in an extensional environment. The high F and low Cl characteristics of the K-feldspar granite are most probably attributed to slab rollback. In the Late Cretaceous, the Xishan Sn-W deposit was located near the interaction of the circum-Pacific and the Tethys tectonic realms. Late Cretaceous Sn-W deposits, including the Xishan deposit, form an EW-trending belt from Guangdong to Yunnan Province in South China. This belt is in accordance with the direction of the Neo-Tethys slab rollback in the Late Cretaceous. In addition, the NS-trending extension has been recognized in the Late Cretaceous in South China. We propose that the Xishan Sn-W deposit should be attributed to the Neo-Tethys slab rollback in the Late Cretaceous.

Investigation of mantle kinematics beneath the Hellenic-subduction zone with teleseismic direct shear waves

NASA Astrophysics Data System (ADS)

Confal, Judith M.; Eken, Tuna; Tilmann, Frederik; Yolsal-Çevikbilen, Seda; Çubuk-Sabuncu, Yeşim; Saygin, Erdinc; Taymaz, Tuncay

2016-12-01

The subduction and roll-back of the African plate beneath the Eurasian plate along the arcuate Hellenic trench is the dominant geodynamic process in the Aegean and western Anatolia. Mantle flow and lithospheric kinematics in this region can potentially be understood better by mapping seismic anisotropy. This study uses direct shear-wave splitting measurements based on the Reference Station Technique in the southern Aegean Sea to reveal seismic anisotropy in the mantle. The technique overcomes possible contamination from source-side anisotropy on direct S-wave signals recorded at a station pair by maximizing the correlation between the seismic traces at reference and target stations after correcting the reference stations for known receiver-side anisotropy and the target stations for arbitrary splitting parameters probed via a grid search. We obtained splitting parameters at 35 stations with good-quality S-wave signals extracted from 81 teleseismic events. Employing direct S-waves enabled more stable and reliable splitting measurements than previously possible, based on sparse SKS data at temporary stations, with one to five events for local SKS studies, compared with an average of 12 events for each station in this study. The fast polarization directions mostly show NNE-SSW orientation with splitting time delays between 1.15 s and 1.62 s. Two stations in the west close to the Hellenic Trench and one in the east show N-S oriented fast polarizations. In the back-arc region three stations exhibit NE-SW orientation. The overall fast polarization variations tend to be similar to those obtained from previous SKS splitting studies in the region but indicate a more consistent pattern, most likely due to the usage of a larger number of individual observations in direct S-wave derived splitting measurements. Splitting analysis on direct shear waves typically resulted in larger split time delays compared to previous studies, possibly because S-waves travel along a longer path in the same anisotropic structure. Considering the S-derived splitting measurements of this study together with earlier SKS and Rayleigh wave anisotropy modelling results we suggest that the very consistent direct S-derived fast shear wave directions can be explained by the lattice-preferred orientation of olivine in the asthenospheric mantle due to mantle flow induced by the roll-back of the slab. It is possible that a small contribution originated in the lower crust beneath the study region where anisotropic fabric might have formed in response to extension in the Miocene.

Radiation therapy and surgery for fibrosarcoma in 33 cats.

PubMed

Cronin, K; Page, R L; Spodnick, G; Dodge, R; Hardie, E N; Price, G S; Ruslander, D; Thrall, D E

1998-01-01

Thirty-three cats with histologically confirmed fibrosarcomas were treated with radiation therapy followed by surgery. The median (95% confidence interval) disease free interval and overall survival were 398 (261,924) and 600 (lower limit 515) days, respectively. There were 19 treatment failures; 11 cats had only local recurrence, 4 cats developed metastatic disease, 3 cats had local recurrence followed by metastasis, and 1 cat developed simultaneous local and distant disease. Twelve cats are alive and disease free. Two cats died without evidence of treatment failure. The presence of tumor cells at the margin of resected tissue after radiation was the only variable which influenced treatment success. The median (95% confidence interval) disease free interval in 5 cats with tumor cells at the margin of the resected specimen was 112 (94,150) days versus 700 (lower limit 328) days for 26 cats with negative tumor margins, p < 0.0001. We did not identify a relationship between tumor volume, number of prior tumor excisions, concomitant use of chemotherapy or various descriptors of the radiation therapy technique and disease free interval.

Effect of long interval between hyperthermochemoradiation therapy and surgery for rectal cancer on apoptosis, proliferation and tumor response.

PubMed

Kato, Toshihide; Fujii, Takaaki; Ide, Munenori; Takada, Takahiro; Sutoh, Toshinaga; Morita, Hiroki; Yajima, Reina; Yamaguchi, Satoru; Tsutsumi, Soichi; Asao, Takayuki; Oyama, Tetsunari; Kuwano, Hiroyuki

2014-06-01

Neoadjuvant chemoradiotherapy is commonly used to improve the local control and resectability of locally advanced rectal cancer, with surgery performed after an interval of a number of weeks. We have been conducting a clinical trial of preoperative chemoradiotherapy in combination with regional hyperthermia (hyperthermo-chemoradiation therapy; HCRT) for locally advanced rectal cancer. In the current study we assessed the effect of a longer (>10 weeks) interval after neoadjuvant HCRT on pathological response, oncological outcome and especially on apoptosis, proliferation and p53 expression in patients with rectal cancer. Forty-eight patients with proven rectal adenocarcinoma who underwent HCRT followed by surgery were identified for inclusion in this study. Patients were divided into two groups according to the interval between HCRT and surgery, ≤ 10 weeks (short-interval group) and >10 weeks (long-interval group). Patients in the long-interval group had a significantly higher rate of pathological complete response (pCR) (43.5% vs. 16.0%) than patients of the short-interval group. Patients of the long-interval group had a significantly higher rate of down-staging of T-stage (78.3% vs. 36.0%) and relatively higher rate of that of N-stage (52.2% vs. 36.0%) than patients of the short-interval group. Furthermore, apoptosis in the long-interval group was relatively higher compared to that of the short-interval group, without a significant difference in the Ki-67 proliferative index and expression of p53 in the primary tumor. In conclusion, we demonstrated that a longer interval after HCRT (>10 weeks) seemed to result in a better chance of a pCR, a result confirmed by the trends in tumor response markers, including apoptosis, proliferation and p53 expression. Copyright© 2014 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

A Model-Based Approach to Infer Shifts in Regional Fire Regimes Over Time Using Sediment Charcoal Records

NASA Astrophysics Data System (ADS)

Itter, M.; Finley, A. O.; Hooten, M.; Higuera, P. E.; Marlon, J. R.; McLachlan, J. S.; Kelly, R.

2016-12-01

Sediment charcoal records are used in paleoecological analyses to identify individual local fire events and to estimate fire frequency and regional biomass burned at centennial to millenial time scales. Methods to identify local fire events based on sediment charcoal records have been well developed over the past 30 years, however, an integrated statistical framework for fire identification is still lacking. We build upon existing paleoecological methods to develop a hierarchical Bayesian point process model for local fire identification and estimation of fire return intervals. The model is unique in that it combines sediment charcoal records from multiple lakes across a region in a spatially-explicit fashion leading to estimation of a joint, regional fire return interval in addition to lake-specific local fire frequencies. Further, the model estimates a joint regional charcoal deposition rate free from the effects of local fires that can be used as a measure of regional biomass burned over time. Finally, the hierarchical Bayesian approach allows for tractable error propagation such that estimates of fire return intervals reflect the full range of uncertainty in sediment charcoal records. Specific sources of uncertainty addressed include sediment age models, the separation of local versus regional charcoal sources, and generation of a composite charcoal record The model is applied to sediment charcoal records from a dense network of lakes in the Yukon Flats region of Alaska. The multivariate joint modeling approach results in improved estimates of regional charcoal deposition with reduced uncertainty in the identification of individual fire events and local fire return intervals compared to individual lake approaches. Modeled individual-lake fire return intervals range from 100 to 500 years with a regional interval of roughly 200 years. Regional charcoal deposition to the network of lakes is correlated up to 50 kilometers. Finally, the joint regional charcoal deposition rate exhibits changes over time coincident with major climatic and vegetation shifts over the past 10,000 years. Ongoing work will use the regional charcoal deposition rate to estimate changes in biomass burned as a function of climate variability and regional vegetation pattern.

Apparatus and method for data communication in an energy distribution network

DOEpatents

Hussain, Mohsin; LaPorte, Brock; Uebel, Udo; Zia, Aftab

2014-07-08

A system for communicating information on an energy distribution network is disclosed. In one embodiment, the system includes a local supervisor on a communication network, wherein the local supervisor can collect data from one or more energy generation/monitoring devices. The system also includes a command center on the communication network, wherein the command center can generate one or more commands for controlling the one or more energy generation devices. The local supervisor can periodically transmit a data signal indicative of the data to the command center via a first channel of the communication network at a first interval. The local supervisor can also periodically transmit a request for a command to the command center via a second channel of the communication network at a second interval shorter than the first interval. This channel configuration provides effective data communication without a significant increase in the use of network resources.

Estimation of TOA based MUSIC algorithm and cross correlation algorithm of appropriate interval

NASA Astrophysics Data System (ADS)

Lin, Wei; Liu, Jun; Zhou, Yineng; Huang, Jiyan

2017-03-01

Localization of mobile station (MS) has now gained considerable attention due to its wide applications in military, environmental, health and commercial systems. Phrase angle and encode data of MSK system model are two critical parameters in time-of-arrival (TOA) localization technique; nevertheless, precise value of phrase angle and encode data are not easy to achieved in general. In order to meet the actual situation, we should consider the condition that phase angle and encode data is unknown. In this paper, a novel TOA localization method, which combine MUSIC algorithm and cross correlation algorithm in an appropriate interval, is proposed. Simulations show that the proposed method has better performance than music algorithm and cross correlation algorithm of the whole interval.

KSC-03pd0075

NASA Image and Video Library

2003-01-15

KENNEDY SPACE CENTER, FLA. -- After rollback of the Rotating Service Structure on Launch Pad 39A, the top of Space Shuttle Columbia's external tank and solid rocket booster are bathed in sunlight. Shadows from the Fixed Service Structure stretch across the Shuttle and landscape. Visible are the orbiter access arm with the White Room extended to Columbia's cockpit, and at the top, the gaseous oxygen vent arm and cap, called the "beanie cap." Columbia is scheduled for launch Jan. 16 at 10:39 a.m. EST on mission STS-107, a research mission.

Multiprocessor system with multiple concurrent modes of execution

DOEpatents

Ahn, Daniel; Ceze, Luis H; Chen, Dong; Gara, Alan; Heidelberger, Philip; Ohmacht, Martin

2013-12-31

A multiprocessor system supports multiple concurrent modes of speculative execution. Speculation identification numbers (IDs) are allocated to speculative threads from a pool of available numbers. The pool is divided into domains, with each domain being assigned to a mode of speculation. Modes of speculation include TM, TLS, and rollback. Allocation of the IDs is carried out with respect to a central state table and using hardware pointers. The IDs are used for writing different versions of speculative results in different ways of a set in a cache memory.

Cache-based error recovery for shared memory multiprocessor systems

NASA Technical Reports Server (NTRS)

Wu, Kun-Lung; Fuchs, W. Kent; Patel, Janak H.

1989-01-01

A multiprocessor cache-based checkpointing and recovery scheme for of recovering from transient processor errors in a shared-memory multiprocessor with private caches is presented. New implementation techniques that use checkpoint identifiers and recovery stacks to reduce performance degradation in processor utilization during normal execution are examined. This cache-based checkpointing technique prevents rollback propagation, provides for rapid recovery, and can be integrated into standard cache coherence protocols. An analytical model is used to estimate the relative performance of the scheme during normal execution. Extensions that take error latency into account are presented.

Multiprocessor system with multiple concurrent modes of execution

DOEpatents

Ahn, Daniel; Ceze, Luis H.; Chen, Dong Chen; Gara, Alan; Heidelberger, Philip; Ohmacht, Martin

2016-11-22

A multiprocessor system supports multiple concurrent modes of speculative execution. Speculation identification numbers (IDs) are allocated to speculative threads from a pool of available numbers. The pool is divided into domains, with each domain being assigned to a mode of speculation. Modes of speculation include TM, TLS, and rollback. Allocation of the IDs is carried out with respect to a central state table and using hardware pointers. The IDs are used for writing different versions of speculative results in different ways of a set in a cache memory.

Changing fluvial styles in volcaniclastic successions: A cretaceous example from the Cerro Barcino Formation, Patagonia

NASA Astrophysics Data System (ADS)

Umazano, A. Martín; Krause, J. Marcelo; Bellosi, Eduardo S.; Perez, Mariano; Visconti, Graciela; Melchor, Ricardo N.

2017-08-01

The Cretaceous Puesto La Paloma (PLPM) and Cerro Castaño (CCM) members (Cerro Barcino Formation, Chubut Group) are pyroclastic-rich, alluvial successions deposited in the Somuncurá-Cañadón Asfalto Basin during sag and endorheic conditions. The PLPM comprises sheet-like tuffaceous sandstone strata, whereas the overlying CCM includes sheet-to ribbon-channel sandstone bodies intercalated within tuffaceous and fine-grained sediments. In this context, the goals of this contribution were: i) to make a detailed documentation of the contrasting sedimentary palaeonvironments; and ii) to infer the allocyclic controls that governed the sedimentation of both units. The study area is located in the western sector of the basin, where six localities, which were studied. Six facies associations were defined including ash-falls, sheet-floods, shallow lakes, aeolian, fluvial channel-belts, and reworked debris-flows. We defined four stratigraphic intervals for the studied sections, denominated 1 to 4 in chronological order of deposition, which increase their thicknesses toward the Puesto Mesa-Cerro León site. The interval 1 (18-42 m thick) corresponds to the PLPM and includes numerous pedogenized sheet-flood deposits, carbonate-rich lacustrine, aeolian sandy facies, and ash-fall beds. The interval 1 is interpreted as an ephemeral and unconfined alluvial system that interacted with aeolian dunes and dry interdune zones. The interval 2 (20-47 m thick) represents the lower part of the CCM. It shows an alternation of fluvial channel-belt deposits and vegetated floodplain facies with sediments originated from sheet-floods, lakes, and few ash-falls and debris-flows. The mean palaeoflow was toward E-SE, except in the northernmost locality where the drainage was towards SW. Proportion of channel-belt bodies ranges from 10 to 36%, reaching higher values in the northern part of the study area, where they are also thicker. The interval 2 represents a permanent, meandering or locally low-sinuosity, fluvial system, and displays both an increase of lacustrine facies and a decrease of ash-fall deposits. The interval 3 (7.5-27 m thick) corresponds to the middle part of the CCM, and lacks channel-belt bodies. It has the highest participation of sheet-flood and ash-fall deposits. This interval entirely records a pedogenized floodplain setting. In relation to the interval 2, participation of debris-flow deposits remains constant and lacustrine facies subtly increases. The interval 4 (18-148 m thick) represents the upper part of the CCM. It comprises an alternation of channel-belt bodies and pedogenized floodplain facies, the last characterized by sheet-flood, lake, debris-flow, and volcanic ash rain deposits. The mean palaeoflow was toward E-SE, except in the two localities positioned further north where the drainage was towards NE and SSE. Proportion of channel-belt deposits ranges from 6 to 32%. It represents channelized and perennial fluvial systems with meandering and locally low-sinuosity styles. Increase in channel proportion and thicker channel bodies are in the northern part of the study area. Particularly, in Puesto Mesa-Cerro León locality this interval is the thickest and has the highest proportion of thicker channel-belt bodies. We interpret these changes in facies architecture as the response to alternated periods of high (intervals 1 and 3) and low (intervals 2 and 4) primary pyroclastic sediment supply. Moreover, there was a climatic change to wetter conditions (intervals 1 to 2-4); as well as intrabasinal tectonic activity in northern area for intervals 2 and 4 inferred from palaeocurrent data.

Modeling of a Turbofan Engine with Ice Crystal Ingestion in the NASA Propulsion System Laboratory

NASA Technical Reports Server (NTRS)

Veres, Joseph P.; Jorgenson, Philip C. E.; Jones, Scott M.; Nili, Samaun

2017-01-01

The main focus of this study is to apply a computational tool for the flow analysis of the turbine engine that has been tested with ice crystal ingestion in the Propulsion Systems Laboratory (PSL) at NASA Glenn Research Center. The PSL has been used to test a highly instrumented Honeywell ALF502R-5A (LF11) turbofan engine at simulated altitude operating conditions. Test data analysis with an engine cycle code and a compressor flow code was conducted to determine the values of key icing parameters, that can indicate the risk of ice accretion, which can lead to engine rollback (un-commanded loss of engine thrust). The full engine aerothermodynamic performance was modeled with the Honeywell Customer Deck specifically created for the ALF502R-5A engine. The mean-line compressor flow analysis code, which includes a code that models the state of the ice crystal, was used to model the air flow through the fan-core and low pressure compressor. The results of the compressor flow analyses included calculations of the ice-water flow rate to air flow rate ratio (IWAR), the local static wet bulb temperature, and the particle melt ratio throughout the flow field. It was found that the assumed particle size had a large effect on the particle melt ratio, and on the local wet bulb temperature. In this study the particle size was varied parametrically to produce a non-zero calculated melt ratio in the exit guide vane (EGV) region of the low pressure compressor (LPC) for the data points that experienced a growth of blockage there, and a subsequent engine called rollback (CRB). At data points where the engine experienced a CRB having the lowest wet bulb temperature of 492 degrees Rankine at the EGV trailing edge, the smallest particle size that produced a non-zero melt ratio (between 3 percent - 4 percent) was on the order of 1 micron. This value of melt ratio was utilized as the target for all other subsequent data points analyzed, while the particle size was varied from 1 micron - 9.5 microns to achieve the target melt ratio. For data points that did not experience a CRB which had static wet bulb temperatures in the EGV region below 492 degrees Rankine, a non-zero melt ratio could not be achieved even with a 1 micron ice particle size. The highest value of static wet bulb temperature for data points that experienced engine CRB was 498 degrees Rankine with a particle size of 9.5 microns. Based on this study of the LF11 engine test data, the range of static wet bulb temperature at the EGV exit for engine CRB was in the narrow range of 492 degrees Rankine - 498 degrees Rankine , while the minimum value of IWAR was 0.002. The rate of blockage growth due to ice accretion and boundary layer growth was estimated by scaling from a known blockage growth rate that was determined in a previous study. These results obtained from the LF11 engine analysis formed the basis of a unique “icing wedge.”

KSC-08pd1505

NASA Image and Video Library

2008-05-30

CAPE CANAVERAL, Fla. -- Bathed in lights surrounding Launch Pad 39A and its structures at NASA's Kennedy Space Center, space shuttle Discovery is poised for launch on the STS-124 mission after rollback of the rotating service structure. First motion was at 8:33 p.m. and rollback was complete at 9:07 p.m. The structure provides protected access to the shuttle for changeout and servicing of payloads at the pad. It is supported by a rotating bridge that pivots on a vertical axis on the west side of the pad's flame trench. After the RSS is rolled back, the orbiter is ready for fuel cell activation and external tank cryogenic propellant loading operations. The pad is cleared to the perimeter gate for operations to fill the external tank with about 500,000 gallons of cryogenic propellants used by the shuttle’s main engines. This is done at the pad approximately eight hours before the scheduled launch. Behind the shuttle is the orange external tank and the two solid rocket boosters (only one seen here). Beneath the shuttle's starboard wing is one of two tail service masts, which provide several umbilical connections to the orbiter, including a liquid-oxygen line through one and a liquid-hydrogen line through another. The STS-124 mission is the second of three flights launching components to complete the Japan Aerospace Exploration Agency's Kibo laboratory. The shuttle crew will install Kibo's large Japanese Pressurized Module and its remote manipulator system, or RMS. The 14-day flight includes three spacewalks. Launch is scheduled for 5:02 p.m. May 31. Photo credit: NASA/Troy Cryder

The formation of the Makassar Strait and the separation between SE Kalimantan and SW Sulawesi

NASA Astrophysics Data System (ADS)

Guntoro, Agus

1999-04-01

The formation of the Makassar Strait, situated between southeast (SE) Kalimantan and western Sulawesi, is still subject of much debate. Different authors have proposed several hypotheses to explain its evolution. The only agreement between those several hypotheses is that SE Kalimantan and western Sulawesi once lay close together and that their separation is due to the opening of the Makassar Strait. The age and driving mechanism for this opening are, however, still poorly understood. The strait separates the stable core of the Eurasian Plate to the west from the very active region of the triple junction of three large plates to the east. To the north the strait is bounded by the Sulawesi Sea and to the south by the East Java Sea. The strait is roughly 100-200 km wide and 300 km long and is usually divided into the North and South Makassar basins, separated by the Paternoster Fault. The present study interprets the history of the Makassar Strait using seismic reflection profiles and gravity models, in addition to the compilation of geological information. Implications for the origin of rifting is also discussed. The result of the present study indicates that Makassar Strait was formed by the vertical sinking of a subducting oceanic plate to the east of western Sulawesi, leading to trench roll-back. This vertical sinking was accommodated by extension and rifting of continental crust above the subduction zone at a previous site of collision, causing the opening of Makassar Strait. The time of this trench roll-back marks the cessation of subduction.

Regimes of plume-slab interaction and consequences for hotspot volcanism

NASA Astrophysics Data System (ADS)

Druken, Kelsey; Stegman, Dave; Kincaid, Christopher; Griffiths, Ross

2013-04-01

"Hotspot" volcanism is generally attributed to upwelling of anomalously warm mantle plumes, the intra-plate Hawaiian island chain and its simple age progression serving as an archetypal example. However, interactions of such plumes with plate margins, and in particular with subduction zones, is likely to have been a common occurrence and leads to more complicated geological records. Here we present results from a series of complementary, three-dimensional numerical and laboratory experiments that examine the dynamic interaction between negatively buoyant subducting slabs and positively buoyant mantle plumes. Slab-driven flow is shown to significantly influence the evolution and morphology of nearby plumes, which leads to a range of deformation regimes of the plume head and conduit. The success or failure of an ascending plume head to reach the lithosphere depends on the combination of plume buoyancy and position within the subduction system, where the mantle flow owing to downdip and rollback components of slab motion entrain plume material both vertically and laterally. Plumes rising within the sub-slab region tend to be suppressed by the surrounding flow field, while wedge-side plumes experience a slight enhancement before ultimately being entrained by subduction. Hotspot motion is more complex than that expected at intraplate settings and is primarily controlled by position alone. Regimes include severely deflected conduits as well as retrograde (corkscrew) motion from rollback-driven flow, often with weak and variable age-progression. The interaction styles and surface manifestations of plumes can be predicted from these models, and the results have important implications for potential hotspot evolution near convergent margins.

Subduction disfigured mantle plumes: Plumes that are not plumes?

NASA Astrophysics Data System (ADS)

Druken, K. A.; Stegman, D. R.; Kincaid, C. R.; Griffiths, R. W.

2012-12-01

"Hotspot" volcanism is generally attributed to upwelling of anomalously warm mantle plumes, the intra-plate Hawaiian island chain and its simple age progression serving as an archetypal example. However, interactions of such plumes with plate margins, and in particular with subduction zones, is likely to have been a common occurrence and leads to more complicated geological records. Here we present results from a series of complementary, three-dimensional numerical and laboratory experiments that examine the dynamic interaction between negatively buoyant subducting slabs and positively buoyant mantle plumes. Slab-driven flow is shown to significantly influence the evolution and morphology of nearby plumes, which leads to a range of deformation regimes of the plume head and conduit. The success or failure of an ascending plume head to reach the lithosphere depends on the combination of plume buoyancy and position within the subduction system, where the mantle flow owing to downdip and rollback components of slab motion entrain plume material both vertically and laterally. Plumes rising within the sub-slab region tend to be suppressed by the surrounding flow field, while wedge-side plumes experience a slight enhancement before ultimately being entrained by subduction. Hotspot motion is more complex than that expected at intraplate settings and is primarily controlled by position alone. Regimes include severely deflected conduits as well as retrograde (corkscrew) motion from rollback-driven flow, often with weak and variable age-progression. The interaction styles and surface manifestations of plumes can be predicted from these models, and the results have important implications for potential hotspot evolution near convergent margins.

Impact of Short Interval SMS Digital Data on Wind Vector Determination for a Severe Local Storms Area

NASA Technical Reports Server (NTRS)

Peslen, C. A.

1979-01-01

The impact of 5 minute interval SMS-2 visible digital image data in analyzing severe local storms is examined using wind vectors derived from cloud tracking on time lapsed sequence of geosynchronous satellite images. The cloud tracking areas are located in the Central Plains, where on 6 May 1975, hail-producing thunderstorms occurred ahead of a well defined dry line. The results demonstrate that satellite-derived wind vectors and their associated divergence fields complement conventional meteorological analyses in describing the conditions preceding severe local storm development.

Entanglement negativity after a local quantum quench in conformal field theories

NASA Astrophysics Data System (ADS)

Wen, Xueda; Chang, Po-Yao; Ryu, Shinsei

2015-08-01

We study the time evolution of the entanglement negativity after a local quantum quench in (1 + 1)-dimensional conformal field theories (CFTs), which we introduce by suddenly joining two initially decoupled CFTs at their end points. We calculate the negativity evolution for both adjacent intervals and disjoint intervals explicitly. For two adjacent intervals, the entanglement negativity grows logarithmically in time right after the quench. After developing a plateau-like feature, the entanglement negativity drops to the ground-state value. For the case of two spatially separated intervals, a light-cone behavior is observed in the negativity evolution; in addition, a long-range entanglement, which is independent of the distance between two intervals, can be created. Our results agree with the heuristic picture that quasiparticles, which carry entanglement, are emitted from the joining point and propagate freely through the system. Our analytical results are confirmed by numerical calculations based on a critical harmonic chain.

Timing of Radiotherapy and Outcome in Patients Receiving Adjuvant Endocrine Therapy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Karlsson, Per, E-mail: per.karlsson@oncology.gu.s; Cole, Bernard F.; International Breast Cancer Study Group Statistical Center, Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA

2011-06-01

Purpose: To evaluate the association between the interval from breast-conserving surgery (BCS) to radiotherapy (RT) and the clinical outcome among patients treated with adjuvant endocrine therapy. Patients and Methods: Patient information was obtained from three International Breast Cancer Study Group trials. The analysis was restricted to 964 patients treated with BCS and adjuvant endocrine therapy. The patients were divided into two groups according to the median number of days between BCS and RT and into four groups according to the quartile of time between BCS and RT. The endpoints were the interval to local recurrence, disease-free survival, and overall survival.more » Proportional hazards regression analysis was used to perform comparisons after adjustment for baseline factors. Results: The median interval between BCS and RT was 77 days. RT timing was significantly associated with age, menopausal status, and estrogen receptor status. After adjustment for these factors, no significant effect of a RT delay {<=}20 weeks was found. The adjusted hazard ratio for RT within 77 days vs. after 77 days was 0.94 (95% confidence interval [CI], 0.47-1.87) for the interval to local recurrence, 1.05 (95% CI, 0.82-1.34) for disease-free survival, and 1.07 (95% CI, 0.77-1.49) for overall survival. For the interval to local recurrence the adjusted hazard ratio for {<=}48, 49-77, and 78-112 days was 0.90 (95% CI, 0.34-2.37), 0.86 (95% CI, 0.33-2.25), and 0.89 (95% CI, 0.33-2.41), respectively, relative to {>=}113 days. Conclusion: A RT delay of {<=}20 weeks was significantly associated with baseline factors such as age, menopausal status, and estrogen-receptor status. After adjustment for these factors, the timing of RT was not significantly associated with the interval to local recurrence, disease-free survival, or overall survival.« less

STS-101 Space Shuttle Atlantis after RSS rollback at Launch Pad 39A

NASA Technical Reports Server (NTRS)

2000-01-01

The Rotating Service Structure (left) begins rolling back from Space Shuttle Atlantis on Launch Pad 39A. Atlantis is targeted for liftoff at 4:15 p.m. EDT April 24 on mission STS-101. The mission will take the crew of seven to the International Space Station to deliver logistics and supplies and prepare the Station for the arrival of the Zvezda Service Module, expected to be launched by Russia in July 2000. Also, the crew will conduct one space walk. This will be the third assembly flight to the Space Station.

Delta II JPSS-1 Rollback

NASA Image and Video Library

2017-11-13

At Vandenberg Air Force Base in California, the gantry rolls back at Space Launch Complex 2 in preparation for the liftoff of the Joint Polar Satellite System-1, or JPSS-1, spacecraft. The United Launch Alliance Delta II rocket now is poised to boost the satellite to a polar orbit. Built by Ball Aerospace and Technologies Corp. of Boulder, Colorado, JPSS is the first in a series four next-generation environmental satellites in a collaborative program between NOAA and NASA. The satellite is scheduled to liftoff at 1:47 a.m. PST (4:47 a.m. EST), on Nov. 14, 2017.

Space Shuttle Endeavour STS-134

NASA Image and Video Library

2011-04-29

An faint profile outline of the space shuttle Endeavour is seen projected in the sky as powerful xenon lights illuminate launch pad 39a shortly after the rollback of the Rotating Service Structure (RSS) from Endeavour, Thursday, April 28, 2011, at Kennedy Space Center in Cape Canaveral, Fla. During the 14-day mission, Endeavour and the STS-134 crew will deliver the Alpha Magnetic Spectrometer (AMS) and spare parts including two S-band communications antennas, a high-pressure gas tank and additional spare parts for Dextre. Launch is targeted for Friday, April 29 at 3:47 p.m. EDT. Photo credit: (NASA/Bill Ingalls)

A conservative approach to parallelizing the Sharks World simulation

NASA Technical Reports Server (NTRS)

Nicol, David M.; Riffe, Scott E.

1990-01-01

Parallelizing a benchmark problem for parallel simulation, the Sharks World, is described. The described solution is conservative, in the sense that no state information is saved, and no 'rollbacks' occur. The used approach illustrates both the principal advantage and principal disadvantage of conservative parallel simulation. The advantage is that by exploiting lookahead an approach was found that dramatically improves the serial execution time, and also achieves excellent speedups. The disadvantage is that if the model rules are changed in such a way that the lookahead is destroyed, it is difficult to modify the solution to accommodate the changes.

STS-104 Atlantis on pad after RSS rollback

NASA Technical Reports Server (NTRS)

2001-01-01

KENNEDY SPACE CENTER, Fla. -- Workers clean the mobile launcher platform on which sits Space Shuttle Atlantis. They are standing in front of one of two tail service masts on either side of the Shuttle, in front of each wing. The masts support the fluid, gas and electrical requirements of the orbiters liquid oxygen and liquid hydrogen aft T-0 umbilicals. Launch on mission STS-104 is scheduled for 5:04 a.m. July 12. The launch is the 10th assembly flight to the International Space Station. Along with a crew of five, Atlantis will carry the joint airlock module as primary payload.

Pilot Study of Adding Vincristine, Topotecan, and Cyclophosphamide to Interval-Compressed Chemotherapy in Newly Diagnosed Patients With Localized Ewing Sarcoma: A Report From the Children's Oncology Group.

PubMed

Mascarenhas, Leo; Felgenhauer, Judy L; Bond, Mason C; Villaluna, Doojduen; Femino, Joseph Dominic; Laack, Nadia N; Ranganathan, Sarangarajan; Meyer, James; Womer, Richard B; Gorlick, Richard; Krailo, Mark D; Marina, Neyssa

2016-03-01

The combination of topotecan and cyclophosphamide is active in relapsed Ewing sarcoma family of tumors (ESFT). The feasibility of adding these agents combined with vincristine (vincristine-topotecan-cyclophosphamide [VTc]) to standard five-drug chemotherapy with vincristine-doxorubicin-cyclophosphamide (VDC) and ifosfamide-etoposide (IE) administered in an interval-compressed (2-week instead of 3-week intervals) schedule was investigated. Newly diagnosed patients with localized ESFT < 31 years, with good performance status and adequate organ function were eligible. Seventeen alternating cycles of chemotherapy with VTc, VDC, and IE were administered at 2-week intervals. Local control (LC) of the primary tumor occurred following six cycles. Primary endpoints were the ability to deliver chemotherapy in an interval-compressed schedule, and the rate of grade 3 or greater nonhematologic toxicity and grade 4 hematologic toxicity, which delayed chemotherapy by ≥2 weeks. Secondary endpoints were event-free survival (EFS) and overall survival (OS). Thirty-five patients with a median age of 11 years were enrolled. The mean time to last dose of chemotherapy prior to LC was 12.6 ± 1.4 weeks and 45.5% of patients received intended chemotherapy without any delay prior to LC. There were no toxic deaths or unexpected toxicities. Five-year EFS was 79.6% (95% confidence interval [CI]: 61.8-89.7%) and 5-year OS was 88% (95% CI: 71.4-95.3%). The addition of VTc to standard therapy was tolerable with sufficient interval compression compared to historical standard 3-week cycles. © 2015 Wiley Periodicals, Inc.

The Effects of a Local Negative Feedback Function between Choice and Relative Reinforcer Rate

PubMed Central

Davison, Michael; Elliffe, Douglas; Marr, M. Jackson

2010-01-01

Four pigeons were trained on two-key concurrent variable-interval schedules with no changeover delay. In Phase 1, relative reinforcers on the two alternatives were varied over five conditions from .1 to .9. In Phases 2 and 3, we instituted a molar feedback function between relative choice in an interreinforcer interval and the probability of reinforcers on the two keys ending the next interreinforcer interval. The feedback function was linear, and was negatively sloped so that more extreme choice in an interreinforcer interval made it more likely that a reinforcer would be available on the other key at the end of the next interval. The slope of the feedback function was −1 in Phase 2 and −3 in Phase 3. We varied relative reinforcers in each of these phases by changing the intercept of the feedback function. Little effect of the feedback functions was discernible at the local (interreinforcer interval) level, but choice measured at an extended level across sessions was strongly and significantly decreased by increasing the negative slope of the feedback function. PMID:21451748

Correlation and taphonomy of late Cretaceous vertebrate localities in Fruitland and Kirtland formations, San Juan basin, New Mexico

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hunt, A.P.

Most fossil vertebrates in the Fruitland and Kirtland formations occur in two narrow stratigraphic intervals. The upper interval comprises the approximately 30 m-thick Naashoibito Member of the Kirtland formation. Fossiliferous localities within this interval are physically correlatable within the small and continuous outcrop belt of this unit. The lower fossiliferous interval comprises a 20 m-thick sequence between the stratigraphically highest, thick coal bed (1 m thick) in the Fruitland Formation and distinctive brown tabular sandstones in the lower Kirtland formation, which differ in color and geometry from adjacent sandstone bodies. Localities within this interval occur in physically discontinuous outcrops, principallymore » between Hunter Wash in the northwest and Coal Creek in the southeast. These localities can be correlated utilizing the upper Fruitland coal, the lower Kirtland sandstones, and a series of volcanic ashes. Measurement of 38 stratigraphic sections and examination of more than 100 subsurface geophysical logs has allowed detailed correlation between the principal areas of vertebrate-fossil occurrences in Hunter Wash and the Fossil Forest. The occurrence of fossils in the Naashoibito is related to energy of depositional environment. Farther north, coarser deposits of the McDermott Member of the Animas Formation, which represent proximal facies of the Naashoibito, lack abundant fossil vertebrates. The geographic extent of vertebrate fossils in the upper Fruitland and lower Kirtland coincides with the extent of the tabular brown sandstones in the lower Kirtland and is related to Laramide downwarping of the central San Juan basin.« less

Cretaceous-Cenozoic Geological Evolution of Tibet: Tectonic Interpretations and Outstanding Questions (Invited)

NASA Astrophysics Data System (ADS)

Kapp, P. A.; Decelles, P. G.; Ding, L.; van Hinsbergen, D. J.

2010-12-01

The India-Asia collision, although profound, is only the most recent in a series of orogenic events that has modified the architecture of the Asian lithosphere. For instance, large parts of central Tibet (Lhasa and Qiangtang terranes) underwent >50% upper-crustal shortening, and likely substantial elevation gain, between Cretaceous and Eocene time in response to Lhasa - Qiangtang continental collision and Andean-style orogenesis along the southern margin of Asia. Findings by independent groups of Gangdese-arc-age detrital zircons in 52-50 Ma Tethyan Himalaya (TH) strata indicate that TH-Asia collision was ongoing by this time. This collision timing is consistent with multiple other, albeit less direct lines of evidence and suggests that a magmatic flare-up within the Gangdese arc (culminated at 52-51 Ma) occurred during subduction of TH lithosphere. Low-temperature thermochronologic data indicate that very low erosion rates, and likely plateau-like conditions considering the shortening history, were established in large parts of central Tibet at or by 50-45 Ma. The temporal-spatial distribution of subsequent shortening and exhumation is consistent with plateau growth northward and southward from central Tibet since the Eocene. The Cenozoic magmatic record of Tibet shows intriguing temporal-spatial patterns. Between 45 Ma and 30 Ma, volcanism swept >600 km northward from the Indus-Yarlung suture (IYS) and then back southward between 30 Ma and 25 Ma. These magmatic sweeps may have been produced by underthrusting and subsequent rollback of subducting TH lithosphere. Recent stratigraphic and structural studies suggest localized extension and elevation loss along the IYS at ~25 Ma, which is explainable in a slab rollback scenario, followed within a few million years by uplift back to near-modern elevations, perhaps in response to breakoff of TH lithosphere and northward underthrusting of Indian lithosphere. This hypothesis of TH - Indian lithosphere subduction can explain how ~2000 km of India-Asia convergence was accommodated south of the IYS since ~50 Ma (with the remaining ~1000 km accommodated by shortening of Asian lithosphere). Outstanding questions include: (1) What are the explanations for major, coeval geological changes in the Lhasa terrane, Gangdese forearc, IYS, and TH at 65-63 Ma, which have led some workers to argue for initiation of India-Asia collision at this time? (2) What was the nature of the subducted TH lithosphere and its former paleogeographic and tectonic relationships to Indian cratonic lithosphere? (3) Why has only <50% of the estimated 2000 km of post-50 Ma convergence south of the Indus-Yarlung suture been documented as shortening within the Tethyan-Himalayan thrust belts? (4) Why did Asian lithosphere in Pamir and Tibet behave so differently in response to collisional orogenesis?

Strain development and kinematic significance of the Alpine folding on Andros (western Cyclades, Greece)

NASA Astrophysics Data System (ADS)

Ziv, A.; Katzir, Y.; Avigad, D.; Garfunkel, Z.

2010-06-01

The general trend of both fold axes and stretching lineation in the Cycladic Blueschist Unit is NE-SW to NNE-SSW. This orientation forms a large angle (almost perpendicular) with respect to the Hellenic trend that is inferred from the main thrusts on mainland Greece. Thus, the kinematic significance of the stretching parallel folding in the Cycladic Blueschist Unit is non-trivial. Since within the western Cyclades, the NE-trending folds are best exposed on the island of Andros, it is a key locality for understanding the timing, style and kinematic significance of folding. Here we show that the NE-trending folds on Andros formed within the stability field of glaucophane, after the peak high-pressure metamorphism and simultaneously with the early stage of retrogression. The axes-parallel stretching was non-rotational; it started during the NE folding at blueschist-facies conditions, and continued long afterward and well into the retrograde greenschist overprint. Furthermore, we present the result of a finite strain calculation which shows that the large NE folds could not have been reoriented at ~ 90° as previously thought. Instead it is suggested that these folds formed under constrictional strain regime during regional NE-SW extension, and represent coeval transverse NW-SE shortening and vertical thinning. This implies that NE extension and southwest directed rollback of the active margin prevailed in the western Aegean between the Eocene and early Miocene.

EPA evaluates air, water controls

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fairley, P.

1996-06-05

Water and air pollution controls make significant contribution to the economy`s health, according to two EPA reports. Clean water provides billions of dollars in benefits to US industries, says a recently released study; and the agency`s draft report on the benefits of air pollution identifiesmore » $$20 in medical costs avoided for every dollar spent on pollution controls. The Clean Water Industry Coalition (CWIC) says the water report reaffirms the need to {open_quotes}modernize{close_quotes} the Clean Water Act (CWA), but EPA administrator Carol Browner says a CWA {open_quotes}rollback{close_quotes} supported by CWIC and passed by House Republicans last May would have jeopardized industries that depend on clean water by weakening effluent standards. Browner denies that the benefits of clean water as identified by the EPA report would have protected water standards from the bill`s cost-benefit requirements. A draft EPA report on clean air leaked by the American Lung Association estimates that tailpipe and smokestack controls for air pollution saved 79,000 lives and resulted in 15 million fewer respiratory illnesses in 1990 alone. The report assesses the costs and benefits of the Clean Air Act from 1970 to 1990. The cost of federal, state, and local regulations were estimated at $$436 billion over the 20-year span, whereas direct benefits of reduced pollution totaled $6.8 trillion.« less

Location of eastern Mediterranean hot springs induced by mantle heat flow due to slab roll-back and tearing

NASA Astrophysics Data System (ADS)

Roche, V. M.; Sternai, P.; Guillou-Frottier, L.; Jolivet, L.; Gerya, T.

2016-12-01

The Aegean-Anatolian retreating subduction and collision zones have been investigated through 3D numerical geodynamic models involving slab rollback/tearing/breakoff constrained by, for instance, seismic tomography or anisotropy and geochemical proxies. Here we integrate these investigations by using geothermal anomaly measurements from western Turkey. Such data provides insights into the thermal state of the Aegean-Anatolian region at depth and reflects the development of a widespread active geothermal province that is unlikely to be related only to the Quaternary volcanism because this has a too limited extent in space and time. Firstly, we look for possible connections with larger-scale mantle dynamics and use 3D high-resolution petrological and thermo-mechanical numerical models to quantify the potential contribution of the Aegean-Anatolian subduction dynamics to such measured thermal anomalies. Secondly, the subduction-induced thermal signature at the base of the continental crust is then inserted as the imposed basal thermal condition of 2D models dedicated to the understanding of fluid flow in the shallow crust. These models couple heat transfer and fluid flow equations with appropriate fluid and rock physical properties. Results from the 3D numerical models suggest an efficient control of subduction-related asthenospheric return flow on the regional distribution of thermal anomalies. Results from the 2D numerical models also highlight that low angle normal faults (detachments) in the back-arc region can control the bulk of the heat transport and fluid circulation patterns. Such detachments can drain hot crustal and/or mantellic fluids down to several kilometers depths, thus allowing for or fostering deep fluid circulation.

KENNEDY SPACE CENTER, FLA. - On Launch Complex 17-A, Cape Canaveral Air Force Station, the Boeing Delta II rocket and its Mars Exploration Rover (MER-A) payload are in the clear after tower rollback in preparation for a second attempt at launch. The first attempt on June 8, 2003, was scrubbed due to bad weather in the vicinity. MER-A is the first of two rovers being launched to Mars. When the two rovers arrive at Mars in 2004, they will bounce to airbag-cushioned landings at sites offering a balance of favorable conditions for safe landings and interesting science. The rovers see sharper images, can explore farther and examine rocks better than anything that has ever landed on Mars. The designated site for MER-A mission is Gusev Crater, which appears to have been a crater lake. The second rover, MER-B, is scheduled to launch June 25.

NASA Image and Video Library

2003-06-09

KENNEDY SPACE CENTER, FLA. - On Launch Complex 17-A, Cape Canaveral Air Force Station, the Boeing Delta II rocket and its Mars Exploration Rover (MER-A) payload are in the clear after tower rollback in preparation for a second attempt at launch. The first attempt on June 8, 2003, was scrubbed due to bad weather in the vicinity. MER-A is the first of two rovers being launched to Mars. When the two rovers arrive at Mars in 2004, they will bounce to airbag-cushioned landings at sites offering a balance of favorable conditions for safe landings and interesting science. The rovers see sharper images, can explore farther and examine rocks better than anything that has ever landed on Mars. The designated site for MER-A mission is Gusev Crater, which appears to have been a crater lake. The second rover, MER-B, is scheduled to launch June 25.

KENNEDY SPACE CENTER, FLA. - On Launch Complex 17-A, Cape Canaveral Air Force Station, the Boeing Delta II rocket and its Mars Exploration Rover (MER-A) payload waits for rollback of the launch tower in preparation for a second attempt at launch. The first attempt on June 8, 2003, was scrubbed due to bad weather in the vicinity. MER-A is the first of two rovers being launched to Mars. When the two rovers arrive at Mars in 2004, they will bounce to airbag-cushioned landings at sites offering a balance of favorable conditions for safe landings and interesting science. The rovers see sharper images, can explore farther and examine rocks better than anything that has ever landed on Mars. The designated site for MER-A mission is Gusev Crater, which appears to have been a crater lake. The second rover, MER-B, is scheduled to launch June 25.

NASA Image and Video Library

2003-06-09

KENNEDY SPACE CENTER, FLA. - On Launch Complex 17-A, Cape Canaveral Air Force Station, the Boeing Delta II rocket and its Mars Exploration Rover (MER-A) payload waits for rollback of the launch tower in preparation for a second attempt at launch. The first attempt on June 8, 2003, was scrubbed due to bad weather in the vicinity. MER-A is the first of two rovers being launched to Mars. When the two rovers arrive at Mars in 2004, they will bounce to airbag-cushioned landings at sites offering a balance of favorable conditions for safe landings and interesting science. The rovers see sharper images, can explore farther and examine rocks better than anything that has ever landed on Mars. The designated site for MER-A mission is Gusev Crater, which appears to have been a crater lake. The second rover, MER-B, is scheduled to launch June 25.

A discussion on the tectonic implications of Ediacaran late- to post-orogenic A-type granite in the northeastern Arabian Shield, Saudi Arabia

NASA Astrophysics Data System (ADS)

Robinson, F. A.; Bonin, B.; Pease, V.; Anderson, J. L.

2017-03-01

The transition from late-orogenic to post-orogenic magmatism following major orogenic episodes such as the Neoproterozoic to Cambrian East African Orogen (EAO) is an important, yet not well-understood geological event marking the cessation of subduction-controlled magmatism between buoyant lithospheric fragments. Forming the northern part of the EAO in the Arabian-Nubian Shield are three granitic suites that successively intruded the same northeastern area and post-date the 640 Ma major orogenic episode: (1) 620-600 Ma alkali feldspar (hypersolvous) granite with alkaline/ferroan/A-type geochemistry, (2) 599 Ma granite cumulates (some garnet-bearing) with calc-alkaline/magnesian affinities, and (3) 584-566 Ma alkali feldspar (hypersolvous) granite (aegirine-bearing) with a distinctive peralkaline/ferroan/A-type signature. Combining whole-rock geochemistry from the southern and northern Arabian Shield, suites 1 and 2 are suggested to be products of late-orogenic slab tear/rollback inducing asthenospheric mantle injection and lower crustal melting/fractionation toward A-type/ferroan geochemistry. Suite 3, however, is suggested to be produced by post-orogenic lithospheric delamination, which replaced the older mantle with new asthenospheric (rare earth element-enriched) mantle that ultimately becomes the thermal boundary layer of the new lithosphere. Major shear zones, such as the 620-540 Ma Najd Fault System (NFS), are some of the last tectonic events recorded across the Arabian Shield. Data presented here suggest that the NFS is directly related to the late-orogenic (620-600 Ma) slab tear/rollback in the northeastern Shield as it met with opposing subduction polarity in the southern Shield. Furthermore, this study infers that east and west Gondwana amalgamation interacted with opposing convergence reflected by the NFS.

KENNEDY SPACE CENTER, FLA. - On Launch Complex 17-B, Cape Canaveral Air Force Station, the Delta II Heavy launch vehicle carrying the second Mars Exploration Rover, Opportunity, is poised for launch after rollback of the Mobile Service Tower. Opportunity will reach Mars on Jan. 25, 2004. Together the two MER rovers, Spirit (launched June 10) and Opportunity, seek to determine the history of climate and water at two sites on Mars where conditions may once have been favorable to life. The rovers are identical. They will navigate themselves around obstacles as they drive across the Martian surface, traveling up to about 130 feet each Martian day. Each rover carries five scientific instruments including a panoramic camera and microscope, plus a rock abrasion tool that will grind away the outer surfaces of rocks to expose their interiors for examination. Each rover’s prime mission is planned to last three months on Mars.

NASA Image and Video Library

2003-07-07

KENNEDY SPACE CENTER, FLA. - On Launch Complex 17-B, Cape Canaveral Air Force Station, the Delta II Heavy launch vehicle carrying the second Mars Exploration Rover, Opportunity, is poised for launch after rollback of the Mobile Service Tower. Opportunity will reach Mars on Jan. 25, 2004. Together the two MER rovers, Spirit (launched June 10) and Opportunity, seek to determine the history of climate and water at two sites on Mars where conditions may once have been favorable to life. The rovers are identical. They will navigate themselves around obstacles as they drive across the Martian surface, traveling up to about 130 feet each Martian day. Each rover carries five scientific instruments including a panoramic camera and microscope, plus a rock abrasion tool that will grind away the outer surfaces of rocks to expose their interiors for examination. Each rover’s prime mission is planned to last three months on Mars.

KSC-08pd1503

NASA Image and Video Library

2008-05-30

CAPE CANAVERAL, Fla. -- Against the dark sky, lights bathe space shuttle Discovery, revealed after rollback of the rotating service structure in preparation for launch on the STS-124 mission. First motion was at 8:33 p.m. and rollback was complete at 9:07 p.m. The rotating structure provides protected access to the shuttle for changeout and servicing of payloads at the pad. It is supported by a rotating bridge that pivots on a vertical axis on the west side of the pad's flame trench. After the RSS is rolled back, the orbiter is ready for fuel cell activation and external tank cryogenic propellant loading operations. The pad is cleared to the perimeter gate for operations to fill the external tank with about 500,000 gallons of cryogenic propellants used by the shuttle’s main engines. This is done at the pad approximately eight hours before the scheduled launch. Above the orange external tank is the oxygen vent hood, called the "beanie cap," at the end of the gaseous oxygen vent arm extending from the fixed service structure. Vapors are created as the liquid oxygen in the external tank boil off. The hood vents the gaseous oxygen vapors away from the space shuttle vehicle. Below is the orbiter access arm with the White Room at the end, flush against the shuttle. The White Room provides access into the shuttle. The STS-124 mission is the second of three flights launching components to complete the Japan Aerospace Exploration Agency's Kibo laboratory. The shuttle crew will install Kibo's large Japanese Pressurized Module and its remote manipulator system, or RMS. The 14-day flight includes three spacewalks. Launch is scheduled for 5:02 p.m. May 31. Photo credit: NASA/Troy Cryder

Craton destruction and related resources

NASA Astrophysics Data System (ADS)

Zhu, Rixiang; Zhang, Hongfu; Zhu, Guang; Meng, Qingren; Fan, Hongrui; Yang, Jinhui; Wu, Fuyuan; Zhang, Zhiyong; Zheng, Tianyu

2017-10-01

Craton destruction is a dynamic event that plays an important role in Earth's evolution. Based on comprehensive observations of many studies on the North China Craton (NCC) and correlations with the evolution histories of other cratons around the world, craton destruction has be defined as a geological process that results in the total loss of craton stability due to changes in the physical and chemical properties of the involved craton. The mechanisms responsible for craton destruction would be as the follows: (1) oceanic plate subduction; (2) rollback and retreat of a subducting oceanic plate; (3) stagnation and dehydration of a subducting plate in the mantle transition zone; (4) melting of the mantle above the mantle transition zone caused by dehydration of a stagnant slab; (5) non-steady flow in the upper mantle induced by melting, and/or (6) changes in the nature of the lithospheric mantle and consequent craton destruction caused by non-steady flow. Oceanic plate subduction itself does not result in craton destruction. For the NCC, it is documented that westward subduction of the paleo-Pacific plate should have initiated at the transition from the Middle-to-Late Jurassic, and resulted in the change of tectonic regime of eastern China. We propose that subduction, rollback and retreat of oceanic plates and dehydration of stagnant slabs are the main dynamic factors responsible for both craton destruction and concentration of mineral deposits, such as gold, in the overriding continental plate. Based on global distribution of gold deposits, we suggest that convergent plate margins are the most important setting for large gold concentrations. Therefore, decratonic gold deposits appear to occur preferentially in regions with oceanic subduction and overlying continental lithospheric destruction/modification/growth.

High-pressure metamorphism in the southern New England Orogen: Implications for long-lived accretionary orogenesis in eastern Australia

NASA Astrophysics Data System (ADS)

Phillips, G.; Offler, R.; Rubatto, D.; Phillips, D.

2015-09-01

New geochemical, metamorphic, and isotopic data are presented from high-pressure metamorphic rocks in the southern New England Orogen (eastern Australia). Conventional and optimal thermobarometry are augmented by U-Pb zircon and 40Ar/39Ar phengite dating to define pressure-temperature-time (P-T-t) histories for the rocks. The P-T-t histories are compared with competing geodynamic models for the Tasmanides, which can be summarized as (i) a retreating orogen model, the Tasmanides formed above a continuous, west dipping, and eastward retreating subduction zone, and (ii) a punctuated orogen model, the Tasmanides formed by several arc accretion, subduction flip, and/or transference events. Whereas both scenarios are potentially supported by the new data, an overlap between the timing of metamorphic recrystallization and key stages of Tasmanides evolution favors a relationship between a single, long-lived subduction zone and the formation, exhumation, and exposure of the high-pressure rocks. By comparison with the retreating orogen model, the following links with the P-T-t histories emerge: (i) exhumation and underplating of oceanic eclogite during the Delamerian Orogeny, (ii) recrystallization of underplated and exhuming high-pressure rocks at amphibolite facies conditions coeval with a period of rollback, and (iii) selective recrystallization of high-pressure rocks at blueschist facies conditions, reflecting metamorphism in a cooled subduction zone. The retreating orogen model can also account for the anomalous location of the Cambrian-Ordovician high-pressure rocks in the Devonian-Carboniferous New England Orogen, where sequential rollback cycles detached and translated parts of the leading edge of the overriding plate to the next, younger orogenic cycle.

Auditory inhibitory gating in medial prefrontal cortex: Single unit and local field potential analysis.

PubMed

Mears, R P; Klein, A C; Cromwell, H C

2006-08-11

Medial prefrontal cortex is a crucial region involved in inhibitory processes. Damage to the medial prefrontal cortex can lead to loss of normal inhibitory control over motor, sensory, emotional and cognitive functions. The goal of the present study was to examine the basic properties of inhibitory gating in this brain region in rats. Inhibitory gating has recently been proposed as a neurophysiological assay for sensory filters in higher brain regions that potentially enable or disable information throughput. This perspective has important clinical relevance due to the findings that gating is dramatically impaired in individuals with emotional and cognitive impairments (i.e. schizophrenia). We used the standard inhibitory gating two-tone paradigm with a 500 ms interval between tones and a 10 s interval between tone pairs. We recorded both single unit and local field potentials from chronic microwire arrays implanted in the medial prefrontal cortex. We investigated short-term (within session) and long-term (between session) variability of auditory gating and additionally examined how altering the interval between the tones influenced the potency of the inhibition. The local field potentials displayed greater variability with a reduction in the amplitudes of the tone responses over both the short and long-term time windows. The decrease across sessions was most intense for the second tone response (test tone) leading to a more robust gating (lower T/C ratio). Surprisingly, single unit responses of different varieties retained similar levels of auditory responsiveness and inhibition in both the short and long-term analysis. Neural inhibition decreased monotonically related to the increase in intertone interval. This change in gating was most consistent in the local field potentials. Subsets of single unit responses did not show the lack of inhibition even for the longer intertone intervals tested (4 s interval). These findings support the idea that the medial prefrontal cortex is an important site where early inhibitory functions reside and potentially mediate psychological processes.

A parallel algorithm for switch-level timing simulation on a hypercube multiprocessor

NASA Technical Reports Server (NTRS)

Rao, Hariprasad Nannapaneni

1989-01-01

The parallel approach to speeding up simulation is studied, specifically the simulation of digital LSI MOS circuitry on the Intel iPSC/2 hypercube. The simulation algorithm is based on RSIM, an event driven switch-level simulator that incorporates a linear transistor model for simulating digital MOS circuits. Parallel processing techniques based on the concepts of Virtual Time and rollback are utilized so that portions of the circuit may be simulated on separate processors, in parallel for as large an increase in speed as possible. A partitioning algorithm is also developed in order to subdivide the circuit for parallel processing.

KSC-99pc02

NASA Image and Video Library

1999-01-03

KENNEDY SPACE CENTER, FLA. -- After launch tower rollback, the Boeing Delta II rocket carrying NASA's Mars Polar lander awaits liftoff, scheduled for 3:21 p.m. EST, at Launch Complex 17B, Cape Canaveral Air Station. The lander is a solar-powered spacecraft designed to touch down on the Martian surface near the northern-most boundary of the south pole in order to study the water cycle there. The lander also will help scientists learn more about climate change and current resources on Mars, studying such things as frost, dust, water vapor and condensates in the Martian atmosphere. It is the second spacecraft to be launched in a pair of Mars Surveyor '98 missions

KSC-00pp1776

NASA Image and Video Library

2000-11-30

After rollback of the Rotating Service Structure (at left), Space Shuttle Endeavour stands ready for launch targeted for 10:06 p.m. EST tonight on mission STS-97 to the International Space Station. The orbiter carries the P6 Integrated Truss Segment containing solar arrays that will be temporarily installed to the Unity connecting module by the Z1 truss, recently delivered to and installed on the Station on mission STS-92. The two solar arrays are each more than 100 feet long. They will capture energy from the sun and convert it to power for the Station. Two spacewalks will be required to install the solar array connections

Modes of orogen-parallel stretching and extensional exhumation in response to microplate indentation and roll-back subduction (Tauern Window, Eastern Alps)

NASA Astrophysics Data System (ADS)

Scharf, A.; Handy, M. R.; Favaro, S.; Schmid, S. M.; Bertrand, A.

2013-09-01

The Tauern Window exposes a Paleogene nappe stack consisting of highly metamorphosed oceanic (Alpine Tethys) and continental (distal European margin) thrust sheets. In the eastern part of this window, this nappe stack (Eastern Tauern Subdome, ETD) is bounded by a Neogene system of shear (the Katschberg Shear Zone System, KSZS) that accommodated orogen-parallel stretching, orogen-normal shortening, and exhumation with respect to the structurally overlying Austroalpine units (Adriatic margin). The KSZS comprises a ≤5-km-thick belt of retrograde mylonite, the central segment of which is a southeast-dipping, low-angle extensional shear zone with a brittle overprint (Katschberg Normal Fault, KNF). At the northern and southern ends of this central segment, the KSZS loses its brittle overprint and swings around both corners of the ETD to become subvertical, dextral, and sinistral strike-slip faults. The latter represent stretching faults whose displacements decrease westward to near zero. The kinematic continuity of top-east to top-southeast ductile shearing along the central, low-angle extensional part of the KSZS with strike-slip shearing along its steep ends, combined with maximum tectonic omission of nappes of the ETD in the footwall of the KNF, indicates that north-south shortening, orogen-parallel stretching, and normal faulting were coeval. Stratigraphic and radiometric ages constrain exhumation of the folded nappe complex in the footwall of the KSZS to have begun at 23-21 Ma, leading to rapid cooling between 21 and 16 Ma. This exhumation involved a combination of tectonic unroofing by extensional shearing, upright folding, and erosional denudation. The contribution of tectonic unroofing is greatest along the central segment of the KSZS and decreases westward to the central part of the Tauern Window. The KSZS formed in response to the indentation of wedge-shaped blocks of semi-rigid Austroalpine basement located in front of the South-Alpine indenter that was part of the Adriatic microplate. Northward motion of this indenter along the sinistral Giudicarie Belt offsets the Periadriatic Fault and triggered rapid exhumation of orogenic crust within the entire Tauern Window. Exhumation involved strike-slip and normal faulting that accommodated about 100 km of orogen-parallel extension and was contemporaneous with about 30 km of orogen-perpendicular, north-south shortening of the ETD. Extension of the Pannonian Basin related to roll-back subduction in the Carpathians began at 20 Ma, but did not affect the Eastern Alps before about 17 Ma. The effect of this extension was to reduce the lateral resistance to eastward crustal flow away from the zone of greatest thickening in the Tauern Window area. Therefore, we propose that roll-back subduction temporarily enhanced rather than triggered exhumation and orogen-parallel motion in the Eastern Alps. Lateral extrusion and orogen-parallel extension in the Eastern Alps have continued from 12 to 10 Ma to the present and are driven by northward push of Adria.

Constraints on the topographic evolution of Corsica and Sardinia from geological and geomorphic analyses

NASA Astrophysics Data System (ADS)

Quye-Sawyer, Jennifer; Whittaker, Alexander; Roberts, Gareth; Rood, Dylan

2017-04-01

The western Mediterranean Sea and its surroundings form part of a well-studied region whose geodynamic history is broadly known. However, how the topography of this area has responded to its tectonic and geodynamic influences is not fully understood. In particular, the relative importance of convergent, extensional and dynamic process is not known. Here we focus on the islands of Corsica, France, and Sardinia, Italy, which have played an important role in Alpine-Apennine system. They experienced a similar kinematic history during the Cenozoic, however their different positions on the Tethyan margin allow the relative effects of Alpine collision and rates of back-arc stretching to be compared. In particular, the two stages of back-arc extension (Liguro-Provençal basin to the west and Tyrrhenian Sea on the east) can provide information about how rollback-induced extension developed with time from the late Oligocene to the present. The two islands are historically tectonically quiescent, however they still preserve evidence of collision and subsequent extension from slab roll-back. In this study we have used a combination of geological and geomorphic techniques to provide new constraints into the vertical motions of Corsica and Sardinia. To quantify the spatial and temporal landscape evolution we have integrated stratigraphic, structural and thermochronological data and re-evaluated these alongside present-day geomorphic and geophysical observations. In addition, we have used digital elevation models to acquire 2030 fluvial longitudinal profiles for both islands. Knickpoints identified on these longitudinal profiles have been compared to geological maps to test the influence of rock strength on erosion. Our analysis reveals the presence of non-lithologically controlled knickpoints which we interpret to have been created by Miocene to Recent changes in uplift rate of the landscape. The longitudinal profiles were subsequently used in drainage inversion modelling, whose results show a spatially and temporally variable evolution of topography. Our results show that the initiation of normal fault bounded sedimentary basins, and the evolution from terrestrial to marine environments, is in agreement with progressive extension with eastward directed slab roll-back. However, observations including angular unconformities alongside terrestrial sedimentation and basalt eruptions during the Pliocene, imply basin inversion and uplift that is broadly simultaneous across both islands from the late Miocene. The magnitude of this uplift was probably variable, reaching several hundred metres in north-central Sardinia. Extension then recommenced as normal faults offset Pliocene units in Sardinia. Many of the islands' major faults have pronounced triangular facets with thick Quaternary alluvium in the hangingwall. Several knickpoints may relate to these fault movements. We evaluate potential causes of the landscape development and we suggest our data are consistent with long-lived tectonic processes in a migrating back-arc since the Oligocene, with minor inversion and uplift to expose the Miocene marine basins.

Coalbed methane potential of the Upper Cretaceous Mesaverde and Meeteetse formations, Wind River Reservation, Wyoming

USGS Publications Warehouse

Johnson, R.C.; Clark, A.C.; Barker, C.E.; Crysdale, B.L.; Higley, D.K.; Szmajter, R.J.; Finn, T.M.

1993-01-01

The environments of deposition of the uppermost part of the Cody Shale and the Mesaverde and Meeteetse Formations of Late Cretaceous age were studied on outcrop in the Shotgun Butte area in the north-central part of the Wind River Reservation. A shoreface sandstone occurs in the lower part of the Mesaverde Formation at all localities studied, and is directly overlain by a coaly interval. Repetitive coarsening-upward cycles of mudstone, siltstone, and sandstone occur in the 200 ft interval of the upper part of the Cody Shale below the shoreface sandstone. These Cody sandstones are typically hummocky cross stratified with symmetrical ripples near the top, indicating that they are largely storm surge deposits that were later reworked. Channel-form sandstones from 10 to 20 ft thick, with abundant locally derived clayey clasts, occur in a 75 ft thick interval below the shoreface at one locality. These unusual sandstones are largely confined to a narrow area of the outcrop and grade laterally into more typical storm surge deposits. They may be unusually large storm surge channels created when high-energy flow conditions were localized to a limited area of the shelf.The Mesaverde Formation above the shoreface sandstone is divided into a middle member and the Teapot Sandstone Member. The lower part of the middle member is everywhere coaly. Erosional-based sandstones in this coaly interval are highly variable in thickness and architecture. Thin, single channel sandstone bodies were deposited by moderate to high sinuosity streams, and thick, multistory channel sandstone bodies were deposited by rapidly switching fluvial channel systems that remained relatively stationary for extended periods of time. The architecture of the fluvial channel sandstones in the overlying noncoaly interval appears to be highly variable as well, with complex multistory sandstones occurring at different stratigraphic levels at different localities. This distribution may be explained by long term stability of fluvial channel systems followed by major avulsion events.The Teapot Sandstone Member consists of fairly persistent to lenticular white multistory sandstone units that are as much as 85 ft thick and contain trough cross beds as much as 5 ft high. These sandstone units are interbedded with gray mudstones and carbonaceous shales. Paleosols are preserved at the tops of individual sandstones in the multistory units in some places. It is suggested that these sandstones were deposited largely by low-sinuosity to braided streams. The Meeteetse Formation consists of alternating coal and sandstone-rich intervals. The coal-rich intervals have relatively thin fluvial channel sandstones probably deposited by medium to high sinuosity streams whereas the sand-rich intervals have thick (to 105 ft) multistory fluvial channel sandstones possibly deposited by low-sinousity to braided streams.

Multi-Residential Activity Labelling in Smart Homes with Wearable Tags Using BLE Technology

PubMed Central

Mokhtari, Ghassem; Zhang, Qing; Karunanithi, Mohanraj

2018-01-01

Smart home platforms show promising outcomes to provide a better quality of life for residents in their homes. One of the main challenges that exists with these platforms in multi-residential houses is activity labeling. As most of the activity sensors do not provide any information regarding the identity of the person who triggers them, it is difficult to label the sensor events in multi-residential smart homes. To deal with this challenge, individual localization in different areas can be a promising solution. The localization information can be used to automatically label the activity sensor data to individuals. Bluetooth low energy (BLE) is a promising technology for this application due to how easy it is to implement and its low energy footprint. In this approach, individuals wear a tag that broadcasts its unique identity (ID) in certain time intervals, while fixed scanners listen to the broadcasting packet to localize the tag and the individual. However, the localization accuracy of this method depends greatly on different settings of broadcasting signal strength, and the time interval of BLE tags. To achieve the best localization accuracy, this paper studies the impacts of different advertising time intervals and power levels, and proposes an efficient and applicable algorithm to select optimal value settings of BLE sensors. Moreover, it proposes an automatic activity labeling method, through integrating BLE localization information and ambient sensor data. The applicability and effectiveness of the proposed structure is also demonstrated in a real multi-resident smart home scenario. PMID:29562666

Multi-Residential Activity Labelling in Smart Homes with Wearable Tags Using BLE Technology.

PubMed

Mokhtari, Ghassem; Anvari-Moghaddam, Amjad; Zhang, Qing; Karunanithi, Mohanraj

2018-03-19

Smart home platforms show promising outcomes to provide a better quality of life for residents in their homes. One of the main challenges that exists with these platforms in multi-residential houses is activity labeling. As most of the activity sensors do not provide any information regarding the identity of the person who triggers them, it is difficult to label the sensor events in multi-residential smart homes. To deal with this challenge, individual localization in different areas can be a promising solution. The localization information can be used to automatically label the activity sensor data to individuals. Bluetooth low energy (BLE) is a promising technology for this application due to how easy it is to implement and its low energy footprint. In this approach, individuals wear a tag that broadcasts its unique identity (ID) in certain time intervals, while fixed scanners listen to the broadcasting packet to localize the tag and the individual. However, the localization accuracy of this method depends greatly on different settings of broadcasting signal strength, and the time interval of BLE tags. To achieve the best localization accuracy, this paper studies the impacts of different advertising time intervals and power levels, and proposes an efficient and applicable algorithm to select optimal value settings of BLE sensors. Moreover, it proposes an automatic activity labeling method, through integrating BLE localization information and ambient sensor data. The applicability and effectiveness of the proposed structure is also demonstrated in a real multi-resident smart home scenario.

United Kingdom national paediatric bilateral project: Demographics and results of localization and speech perception testing.

PubMed

Cullington, H E; Bele, D; Brinton, J C; Cooper, S; Daft, M; Harding, J; Hatton, N; Humphries, J; Lutman, M E; Maddocks, J; Maggs, J; Millward, K; O'Donoghue, G; Patel, S; Rajput, K; Salmon, V; Sear, T; Speers, A; Wheeler, A; Wilson, K

2017-01-01

To assess longitudinal outcomes in a large and varied population of children receiving bilateral cochlear implants both simultaneously and sequentially. This observational non-randomized service evaluation collected localization and speech recognition in noise data from simultaneously and sequentially implanted children at four time points: before bilateral cochlear implants or before the sequential implant, 1 year, 2 years, and 3 years after bilateral implants. No inclusion criteria were applied, so children with additional difficulties, cochleovestibular anomalies, varying educational placements, 23 different home languages, a full range of outcomes and varying device use were included. 1001 children were included: 465 implanted simultaneously and 536 sequentially, representing just over 50% of children receiving bilateral implants in the UK in this period. In simultaneously implanted children the median age at implant was 2.1 years; 7% were implanted at less than 1 year of age. In sequentially implanted children the interval between implants ranged from 0.1 to 14.5 years. Children with simultaneous bilateral implants localized better than those with one implant. On average children receiving a second (sequential) cochlear implant showed improvement in localization and listening in background noise after 1 year of bilateral listening. The interval between sequential implants had no effect on localization improvement although a smaller interval gave more improvement in speech recognition in noise. Children with sequential implants on average were able to use their second device to obtain spatial release from masking after 2 years of bilateral listening. Although ranges were large, bilateral cochlear implants on average offered an improvement in localization and speech perception in noise over unilateral implants. These data represent the diverse population of children with bilateral cochlear implants in the UK from 2010 to 2012. Predictions of outcomes for individual patients are not possible from these data. However, there are no indications to preclude children with long inter-implant interval having the chance of a second cochlear implant.

Genomic Correlates of Relationship QTL Involved in Fore- versus Hind Limb Divergence in Mice

PubMed Central

Pavlicev, Mihaela; Wagner, Günter P.; Noonan, James P.; Hallgrímsson, Benedikt; Cheverud, James M.

2013-01-01

Divergence of serially homologous elements of organisms is a common evolutionary pattern contributing to increased phenotypic complexity. Here, we study the genomic intervals affecting the variational independence of fore- and hind limb traits within an experimental mouse population. We use an advanced intercross of inbred mouse strains to map the loci associated with the degree of autonomy between fore- and hind limb long bone lengths (loci affecting the relationship between traits, relationship quantitative trait loci [rQTL]). These loci have been proposed to interact locally with the products of pleiotropic genes, thereby freeing the local trait from the variational constraint due to pleiotropic mutations. Using the known polymorphisms (single nucleotide polymorphisms [SNPs]) between the parental strains, we characterized and compared the genomic regions in which the rQTL, as well as their interaction partners (intQTL), reside. We find that these two classes of QTL intervals harbor different kinds of molecular variation. SNPs in rQTL intervals more frequently reside in limb-specific cis-regulatory regions than SNPs in intQTL intervals. The intQTL loci modified by the rQTL, in contrast, show the signature of protein-coding variation. This result is consistent with the widely accepted view that protein-coding mutations have broader pleiotropic effects than cis-regulatory polymorphisms. For both types of QTL intervals, the underlying candidate genes are enriched for genes involved in protein binding. This finding suggests that rQTL effects are caused by local interactions among the products of the causal genes harbored in rQTL and intQTL intervals. This is the first study to systematically document the population-level molecular variation underlying the evolution of character individuation. PMID:24065733

Gravity drives Great Earthquakes

NASA Astrophysics Data System (ADS)

Lister, Gordon; Forster, Marnie

2010-05-01

The most violent of Great Earthquakes are driven by ruptures on giant megathrusts adjacent to actively forming mountain belts. Current theory suggests that the seismic rupture harvests (and thus releases) elastic energy that has been previously stored in locked segments of the megathrust. The general belief, however, is that this energy was accumulated as the result of relative motion of the adjacent stiff elastic tectonic plates. This mechanism fails to explain many first order aspects of large earthquakes, however. The energy source for strain accumulation must also include gravitational collapse of orogenic crust and/or in the foundering (or roll-back) of an adjacent subducting lithospheric slab. Therefore we have conducted an analysis of the geometry of aftershocks, and report that this allows distinction of two types of failure on giant megathrusts. Mode I failure involves horizontal shortening, and is consistent with the classic view that megathrusts fail in compression, with motion analogous to that expected if accretion takes place against a rigid (or elastic) backstop. Mode II failure involves horizontal extension, and requires the over-riding plate to stretch during an earthquake. This process is likely to continue during the subsequent period of afterslip, and therefore will again be evident in aftershock patterns. Mode I behaviour may well have applied to the southern segment of the Sumatran megathrust, from whence emanated the rupture that drove the 2004 Great Earthquake. Mode II behaviour appears to apply to the northern segment of the same rupture, however. The geometry of aftershocks beneath the Andaman Sea suggest that the crust above the initial rupture failed in an extensional mode. The edge of the Indian plate is foundering, with slab-hinge roll-back in a direction orthogonal to its motion vector. The only possible cause for this extension therefore is westward roll-back of the subducting Indian plate, and the consequent gravity-driven movement of the over-riding crust and mantle. This is possible for the crust and mantle above major subduction zones is mechanically weakened by the flux of heat and water associated with subduction zone processes. In consequence the lithosphere of the over-riding orogens can act more like a fluid than a rigid plate. Such fluid-like behaviour has been noted for the Himalaya and for the crust of the uplifted adjacent Tibetan Plateau, which appear to be collapsing. Similar conclusions as to the fluid-like behaviour of an orogen can also be reached for the crust and mantle of Myanmar and Indonesia, since here again, there is evidence for arc-normal motion adjacent to rolling-back subduction zones. Prior to the Great Sumatran Earthquake of 2004 we had postulated such movements on geological time-scales, describing them as ‘surges‘ driven by the gravitational potential energy of the adjacent orogen. But we considered time-scales that were very different to those that apply in the lead up, or during and subsequent to a catastrophic seismic event. The Great Sumatran Earthquake taught us quite differently. Data from satellites support the hypothesis that extension took place in a discrete increment, which we interpret to be the result of a gravitationally driven surge of the Indonesian crust westward over the weakened rupture during and after the earthquake. Mode II megathrusts are tsunamigenic for one very simple reason: the crust has been attenuated as the result of ongoing extension, so they can be overlain by large tracts of water, and they have a long rupture run time, allowing a succession of stress accumulations to be harvested. The after-slip beneath the Andaman Sea was also significant (in terms of moment) although non-seismogenic in its character. Operation of a Mode II megathrust prior to catastrophic failure may involve relatively quiescent motion with a mixture of normal faults and reverse faults, much like south of Java today. Ductile yield may produce steadily increasing (and accelerating) subsidence (on decadal time scales) as roll-back deepens the trench and adjacent fore-arc basins. This suggests a relatively simple (and cost effective) strategy that would allow precursor motions on Mode II megathrusts to be precisely monitored.

Differentiating the origin of outflow tract ventricular arrhythmia using a simple, novel approach.

PubMed

Efimova, Elena; Dinov, Borislav; Acou, Willem-Jan; Schirripa, Valentina; Kornej, Jelena; Kosiuk, Jedrzej; Rolf, Sascha; Sommer, Philipp; Richter, Sergio; Bollmann, Andreas; Hindricks, Gerhard; Arya, Arash

2015-07-01

Numerous electrocardiographic (ECG) criteria have been proposed to identify localization of outflow tract ventricular arrhythmias (OT-VAs); however, in some cases, it is difficult to accurately localize the origin of OT-VA using the surface ECG. The purpose of this study was to assess a simple criterion for localization of OT-VAs during electrophysiology study. We measured the interval from the onset of the earliest QRS complex of premature ventricular contractions (PVCs) to the distal right ventricular apical signal (the QRS-RVA interval) in 66 patients (31 men aged 53.3 ± 14.0 years; right ventricular outflow tract [RVOT] origin in 37) referred for ablation of symptomatic outflow tract PVCs. We prospectively validated this criterion in 39 patients (22 men aged 52 ± 15 years; RVOT origin in 19). Compared with patients with RVOT PVCs, the QRS-RVA interval was significantly longer in patients with left ventricular outflow tract (LVOT) PVCs (70 ± 14 vs 33.4±10 ms, P < .001). Receiver operating characteristic analysis showed that a QRS-RVA interval ≥49 ms had sensitivity, specificity, and positive and negative predictive values of 100%, 94.6%, 93.5%, and 100%, respectively, for prediction of an LVOT origin. The same analysis in the validation cohort showed sensitivity, specificity, and positive and negative predictive values of 94.7%, 95%, 95%, and 94.7%, respectively. When these data were combined, a QRS-RVA interval ≥49 ms had sensitivity, specificity, and positive and negative predictive values of 98%, 94.6%, 94.1%, and 98.1%, respectively, for prediction of an LVOT origin. A QRS-RVA interval ≥49 ms suggests an LVOT origin. The QRS-RVA interval is a simple and accurate criterion for differentiating the origin of outflow tract arrhythmia during electrophysiology study; however, the accuracy of this criterion in identifying OT-VA from the right coronary cusp is limited. Copyright © 2015 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.

Checkpointing in speculative versioning caches

DOEpatents

Eichenberger, Alexandre E; Gara, Alan; Gschwind, Michael K; Ohmacht, Martin

2013-08-27

Mechanisms for generating checkpoints in a speculative versioning cache of a data processing system are provided. The mechanisms execute code within the data processing system, wherein the code accesses cache lines in the speculative versioning cache. The mechanisms further determine whether a first condition occurs indicating a need to generate a checkpoint in the speculative versioning cache. The checkpoint is a speculative cache line which is made non-speculative in response to a second condition occurring that requires a roll-back of changes to a cache line corresponding to the speculative cache line. The mechanisms also generate the checkpoint in the speculative versioning cache in response to a determination that the first condition has occurred.

KSC-00pp1775

NASA Image and Video Library

2000-11-30

Against a cloudless blue sky, Space Shuttle Endeavour stands ready for launch after the rollback of the Rotating Service Structure, at left. Endeavour is targeted for launch tonight at about 10:06 p.m. EST on mission STS-97 to the International Space Station. The orbiter carries the P6 Integrated Truss Segment containing solar arrays that will be temporarily installed to the Unity connecting module by the Z1 truss, recently delivered to and installed on the Station on mission STS-92. The two solar arrays are each more than 100 feet long. They will capture energy from the sun and convert it to power for the Station. Two spacewalks will be required to install the solar array connections

STS-104 Atlantis on pad after RSS rollback

NASA Technical Reports Server (NTRS)

2001-01-01

KENNEDY SPACE CENTER, Fla. -- This view from above Space Shuttle Atlantis reduces the workers below to appearing like ants. Seen below the Shuttle is the opening over the exhaust hole containing flame detectors. On either side of the Atlantis, in front of the wings, are two tail service masts. The masts support the fluid, gas and electrical requirements of the orbiters liquid oxygen and liquid hydrogen aft T-0 umbilicals. Launch on mission STS-104 is scheduled for 5:04 a.m. July 12. The launch is the 10th assembly flight to the International Space Station. Along with a crew of five, Atlantis will carry the joint airlock module as primary payload.

Error recovery in shared memory multiprocessors using private caches

NASA Technical Reports Server (NTRS)

Wu, Kun-Lung; Fuchs, W. Kent; Patel, Janak H.

1990-01-01

The problem of recovering from processor transient faults in shared memory multiprocesses systems is examined. A user-transparent checkpointing and recovery scheme using private caches is presented. Processes can recover from errors due to faulty processors by restarting from the checkpointed computation state. Implementation techniques using checkpoint identifiers and recovery stacks are examined as a means of reducing performance degradation in processor utilization during normal execution. This cache-based checkpointing technique prevents rollback propagation, provides rapid recovery, and can be integrated into standard cache coherence protocols. An analytical model is used to estimate the relative performance of the scheme during normal execution. Extensions to take error latency into account are presented.

Reducing Interprocessor Dependence in Recoverable Distributed Shared Memory

NASA Technical Reports Server (NTRS)

Janssens, Bob; Fuchs, W. Kent

1994-01-01

Checkpointing techniques in parallel systems use dependency tracking and/or message logging to ensure that a system rolls back to a consistent state. Traditional dependency tracking in distributed shared memory (DSM) systems is expensive because of high communication frequency. In this paper we show that, if designed correctly, a DSM system only needs to consider dependencies due to the transfer of blocks of data, resulting in reduced dependency tracking overhead and reduced potential for rollback propagation. We develop an ownership timestamp scheme to tolerate the loss of block state information and develop a passive server model of execution where interactions between processors are considered atomic. With our scheme, dependencies are significantly reduced compared to the traditional message-passing model.

Pathologic Response, When Increased by Longer Interval, Is a Marker but Not the Cause of Good Prognosis in Rectal Cancer: 17-year Follow-up of the Lyon R90-01 Randomized Trial

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cotte, Eddy, E-mail: eddy.cotte@chu-lyon.fr; Lyon 1 University, EMR 3738, Lyon-Sud/Charles Mérieux Medical University, Oullins; Passot, Guillaume

Purpose: The Lyon R90-01 randomized trial investigated whether the interval between preoperative radiation therapy and surgery influenced rectal cancer outcome. Long-term results are reported here after a median follow-up of 17 years. Methods and Materials: Between February 1991 and December 1995, 210 patients from 29 French centers were randomly assigned (ratio of 1:1) to groups that waited either 2 weeks (short interval [SI]) or 6 to 8 weeks (long interval [LI]) between neoadjuvant radiation therapy and surgery. The primary endpoint was sphincter-preserving surgery. Results: LI group showed a better pathologic response (complete response or few residual cells) after radiation therapy than the SImore » group (26% vs 10.3%, P=.015). A better pathologic response was associated in multivariate analysis with significant improvement of overall survival (pT: P=.0293 and pN: P=.0048) but it was irrespective of the interval duration. The median follow-up was 17.2 years. The 5-, 10-, 15-, and 17-year overall survival rates were, respectively, 66.8%, 48.7%, 40.0%, and 34.0% for the SI group and, respectively, 67.1%, 53.5%, 41.9%, and 34.0% for the LI group. There were no significant differences between groups in terms of survival (P=.7656) or local recurrence rates (SI: 14.4% vs LI: 12.1%, respectively; P=.6202). Of 24 local disease recurrences, 20 (83%) occurred during the first 2 postoperative years, and all but one (96%) occurred during the first 5 postoperative years. The rate of second new malignancies was 9.4% (19 patients). Conclusions: The radiation-induced sterilization rate of the preoperative cancer specimen was a marker of good prognosis. The interval duration (the treatment being the same) although it is modifying the sterilization rate has no impact on survival. Radiation therapy did not postpone local recurrence, because the rate of local relapse after 5 years was low. Radiation-induced cancers after radiation therapy were unusual and should not influence treatment decisions in adults.« less

Time Interval From Breast-Conserving Surgery to Breast Irradiation in Early Stage Node-Negative Breast Cancer: 17-Year Follow-Up Results and Patterns of Recurrence

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vujovic, Olga, E-mail: olga.vujovic@lhsc.on.ca; Yu, Edward; Cherian, Anil

Purpose: A retrospectivechart review was conducted to determine whether the time interval from breast-conserving surgery to breast irradiation (surgery-radiation therapy interval) in early stage node-negative breast cancer had any detrimental effects on recurrence rates. Methods and Materials: There were 566 patients with T1 to T3, N0 breast cancer treated with breast-conserving surgery and breast irradiation and without adjuvant systemic treatment between 1985 and 1992. The surgery-to-radiation therapy intervals used for analysis were 0 to 8 weeks (201 patients), >8 to 12 weeks (233 patients), >12 to 16 weeks (91 patients), and >16 weeks (41 patients). Kaplan-Meier estimates of time to local recurrence, disease-free survival, distantmore » disease-free survival, cause-specific survival, and overall survival rates were calculated. Results: Median follow-up was 17.4 years. Patients in all 4 time intervals were similar in terms of characteristics and pathologic features. There were no statistically significant differences among the 4 time groups in local recurrence (P=.67) or disease-free survival (P=.82). The local recurrence rates at 5, 10, and 15 years were 4.9%, 11.5%, and 15.0%, respectively. The distant disease relapse rates at 5, 10, and 15 years were 10.6%, 15.4%, and 18.5%, respectively. The disease-free failure rates at 5, 10, and 15 years were 20%, 32.3%, and 39.8%, respectively. Cause-specific survival rates at 5, 10, and 15 years were 92%, 84.6%, and 79.8%, respectively. The overall survival rates at 5, 10, and 15 years were 89.3%, 79.2%, and 66.9%, respectively. Conclusions: Surgery-radiation therapy intervals up to 16 weeks from breast-conserving surgery are not associated with any increased risk of recurrence in early stage node-negative breast cancer. There is a steady local recurrence rate of 1% per year with adjuvant radiation alone.« less

GABAergic Local Interneurons Shape Female Fruit Fly Response to Mating Songs.

PubMed

Yamada, Daichi; Ishimoto, Hiroshi; Li, Xiaodong; Kohashi, Tsunehiko; Ishikawa, Yuki; Kamikouchi, Azusa

2018-05-02

Many animals use acoustic signals to attract a potential mating partner. In fruit flies ( Drosophila melanogaster ), the courtship pulse song has a species-specific interpulse interval (IPI) that activates mating. Although a series of auditory neurons in the fly brain exhibit different tuning patterns to IPIs, it is unclear how the response of each neuron is tuned. Here, we studied the neural circuitry regulating the activity of antennal mechanosensory and motor center (AMMC)-B1 neurons, key secondary auditory neurons in the excitatory neural pathway that relay song information. By performing Ca 2+ imaging in female flies, we found that the IPI selectivity observed in AMMC-B1 neurons differs from that of upstream auditory sensory neurons [Johnston's organ (JO)-B]. Selective knock-down of a GABA A receptor subunit in AMMC-B1 neurons increased their response to short IPIs, suggesting that GABA suppresses AMMC-B1 activity at these IPIs. Connection mapping identified two GABAergic local interneurons that synapse with AMMC-B1 and JO-B. Ca 2+ imaging combined with neuronal silencing revealed that these local interneurons, AMMC-LN and AMMC-B2, shape the response pattern of AMMC-B1 neurons at a 15 ms IPI. Neuronal silencing studies further suggested that both GABAergic local interneurons suppress the behavioral response to artificial pulse songs in flies, particularly those with a 15 ms IPI. Altogether, we identified a circuit containing two GABAergic local interneurons that affects the temporal tuning of AMMC-B1 neurons in the song relay pathway and the behavioral response to the courtship song. Our findings suggest that feedforward inhibitory pathways adjust the behavioral response to courtship pulse songs in female flies. SIGNIFICANCE STATEMENT To understand how the brain detects time intervals between sound elements, we studied the neural pathway that relays species-specific courtship song information in female Drosophila melanogaster We demonstrate that the signal transmission from auditory sensory neurons to key secondary auditory neurons antennal mechanosensory and motor center (AMMC)-B1 is the first-step to generate time interval selectivity of neurons in the song relay pathway. Two GABAergic local interneurons are suggested to shape the interval selectivity of AMMC-B1 neurons by receiving auditory inputs and in turn providing feedforward inhibition onto AMMC-B1 neurons. Furthermore, these GABAergic local interneurons suppress the song response behavior in an interval-dependent manner. Our results provide new insights into the neural circuit basis to adjust neuronal and behavioral responses to a species-specific communication sound. Copyright © 2018 the authors 0270-6474/18/384329-19$15.00/0.

Fluorine 18 fluorodeoxyglucose PET/CT volume-based indices in locally advanced non-small cell lung cancer: prediction of residual viable tumor after induction chemotherapy.

PubMed

Soussan, Michael; Cyrta, Joanna; Pouliquen, Christelle; Chouahnia, Kader; Orlhac, Fanny; Martinod, Emmanuel; Eder, Véronique; Morère, Jean-François; Buvat, Irène

2014-09-01

To study whether volume-based indices of fluorine 18 fluorodeoxyglucose positron emission tomographic (PET)/computed tomographic (CT) imaging is an accurate tool to predict the amount of residual viable tumor after induction chemotherapy in patients with locally advanced non-small cell lung cancer (NSCLC). This study was approved by institutional review board with waivers of informed consent. Twenty-two patients with locally advanced NSCLC underwent surgery after induction chemotherapy. All had pre- and posttreatment FDG PET/CT scans. CT largest diameter, CT volume, maximum standardized uptake value (SUVmax), mean SUV (SUVmean), metabolic tumor volume (TV), and total lesion glycolysis of primary tumor were calculated. Changes in tumor measurements were determined by dividing follow-up by baseline measurement (ratio index). Amounts of residual viable tumor, necrosis, fibrous tissue, inflammatory infiltrate, and Ki-67 proliferative index were estimated on resected tumor. Correlations between imaging indices and histologic parameters were estimated by using Spearman correlation coefficients or Mann-Whitney tests. No baseline or posttreatment indices correlated with percentage of residual viable tumor. TV ratio was the only index that correlated with percentage of residual viable tumor (r = 0.61 [95% confidence interval: 0.24, 0.81]; P = .003). Conversely, SUVmax and SUVmean ratios were only indices correlated with Ki-67 (r = 0.62 [95% confidence interval: 0.24, 0.82]; P = .003; and r = 0.60 [95% confidence interval: 0.21, 0.81]; P = .004, respectively). Total lesion glycolysis ratio was moderately correlated with residual viable tumor (r = 0.53 [95% confidence interval: 0.13, 0.78]; P = .01) and with Ki-67 (r = 0.57 [95% confidence interval: 0.18, 0.80]; P = .006). No ratios were correlated with presence of inflammatory infiltrate or foamy macrophages. TV and total lesion glycolysis ratios were the only indices correlated with residual viable tumor after induction chemotherapy in locally advanced NSCLC.

Pockets, conduits, channels, and plumes: links to volcanism and orogeny in the rollback dominated western Mediterranean

NASA Astrophysics Data System (ADS)

Miller, Meghan S.; Sun, Daoyuan; O'Driscoll, Leland; Becker, Thorsten W.; Holt, Adam; Diaz, Jordi; Thomas, Christine

2015-04-01

Detailed mantle and lithospheric structure from the Canary Islands to Iberia have been imaged with data from recent temporary deployments and select permanent stations from over 300 broadband seismometers. The stations extended across Morocco and Spain as part of the PICASSO, IberArray, and Morocco-Münster experiments. We present results from S receiver functions (SRF), shear wave splitting, waveform modeling, and geodynamic models that help constrain the tectonic evolution of the westernmost Mediterranean, including orogenesis of the Atlas Mountains and occurrence of localized alkaline volcanism. Our receiver function images, in agreement with previous geophysical modeling, show that the lithosphere is thin (~65 km) beneath the Atlas, but thickens (~100 km) over a very short length scale at the flanks of the mountains. We find that these dramatic changes in lithospheric thickness also correspond to dramatic decreases in delay times inferred from S and SKS splitting observations of seismic anisotropy. Pockets and conduits of low seismic velocity material below the lithosphere extend along much of the Atlas to Southern Spain and correlate with the locations of Pliocene-Quaternary magmatism. Waveform analysis from the USC linear seismic array across the Atlas Mountains constrains the position, shape, and physical characteristics of one localized, low velocity conduit that extends from the uppermost mantle (~200 km depth) up to the volcanoes in the Middle Atlas. The shape, position and temperature of these seismically imaged low velocity anomalies, topography of the base of the lithosphere, morphology of the subducted slab beneath the Alboran Sea, position of the West African Craton and correlation with mantle flow inferred from shear wave splitting suggest that the unusually high topography of the Atlas Mountains and isolated recent volcanics are due to active mantle support that may be from material channeled from the Canary Island plume.

Global and local music perception in children with Williams syndrome.

PubMed

Deruelle, Christine; Schön, Daniele; Rondan, Cécilie; Mancini, Josette

2005-04-25

Musical processing can be decomposed into the appreciation of global and local elements. This global/local dissociation was investigated with the processing of contour-violated and interval-violated melodies. Performance of a group of 16 children with Williams syndrome and a group of 16 control children were compared in a same-different task. Control participants were more accurate in detecting differences in the contour-violated than in the interval-violated condition while Williams syndrome individuals performed equally well in both conditions. This finding suggests that global precedence may occur at an early perceptual stage in normally developing children. In contrast, no such global precedence is observed in the Williams syndrome population. These data are discussed in the context of atypical cognitive profiles of individuals with Williams syndrome.

On the role of horizontal displacements in the exhumation of high pressure metamorphic rocks

NASA Astrophysics Data System (ADS)

Brun, J.-P.; Tirel, C.; Philippon, M.; Burov, E.; Faccenna, C.; Gueydan, F.; Lebedev, S.

2012-04-01

High pressure metamorphic rocks exposed in the core of many mountain belts correspond to various types of upper crustal materials that have been buried to mantle depths and, soon after, brought back to surface at mean displacement rates up to few cm/y, comparable to those of plate boundaries. The vertical component of HP rock exhumation velocity back to surface is commonly well constrained by pressure estimates from petrology and geochronological data whereas the horizontal component remains generally difficult or impossible to estimate. Consequently, most available models, if not all, attempt to simulate exhumation with a minimal horizontal component of displacement. Such models, require that the viscosity of HP rocks is low and/or the erosion rate large -i.e. at least equal to the rate of exhumation. However, in some regions like the Aegean, where the exhumation of blueschists and eclogites is driven by slab rollback, it can be shown that the horizontal component of exhumation related displacement, obtained from map view restoration, is 5 to 7 times larger than the vertical one, deduced from metamorphic pressure estimates. Using finite element models performed with FLAMAR, we show that such a situation simply results from the subduction of small continental blocks (< 500km) that stimulate subduction rollback. The continental block is dragged downward and sheared off the downgoing mantle slab by buoyancy force. Exhumation of the crustal block occurs through a one step Caterpillar-type walk, with the block's tail slipping along a basal décollement, approaching the head and making a large buckle, which then unrolls at surface as soon as the entire block is delaminated. Finally, the crustal block emplaces at surface in the space created by trench retreat. This process of exhumation requires neither rheological weakening of HP rocks nor high rates of erosion.

Modeling Diverse Pathways to Age Progressive Volcanism in Subduction Zones.

NASA Astrophysics Data System (ADS)

Kincaid, C. R.; Szwaja, S.; Sylvia, R. T.; Druken, K. A.

2015-12-01

One of the best, and most challenging clues to unraveling mantle circulation patterns in subduction zones comes in the form of age progressive volcanic and geochemical trends. Hard fought geological data from many subduction zones, like Tonga-Lau, the Cascades and Costa-Rica/Nicaragua, reveal striking temporal patterns used in defining mantle flow directions and rates. We summarize results from laboratory subduction models showing a range in circulation and thermal-chemical transport processes. These interaction styles are capable of producing such trends, often reflecting apparent instead of actual mantle velocities. Lab experiments use a glucose working fluid to represent Earth's upper mantle and kinematically driven plates to produce a range in slab sinking and related wedge transport patterns. Kinematic forcing assumes most of the super-adiabatic temperature gradient available to drive major downwellings is in the tabular slabs. Moreover, sinking styles for fully dynamic subduction depend on many complicating factors that are only poorly understood and which can vary widely even for repeated parameter combinations. Kinematic models have the benefit of precise, repeatable control of slab motions and wedge flow responses. Results generated with these techniques show the evolution of near-surface thermal-chemical-rheological heterogeneities leads to age progressive surface expressions in a variety of ways. One set of experiments shows that rollback and back-arc extension combine to produce distinct modes of linear, age progressive melt delivery to the surface through a) erosion of the rheological boundary layer beneath the overriding plate, and deformation and redistribution of both b) mantle residuum produced from decompression melting and c) formerly active, buoyant plumes. Additional experiments consider buoyant diapirs rising in a wedge under the influence of rollback, back-arc spreading and slab-gaps. Strongly deflected diapirs, experiencing variable rise rates, also commonly surface as linear, age progressive tracks. Applying these results to systems like the Cascades and Tonga-Lau suggest there are multiple ways to produce timing trends due both to linear flows and waves of heterogeneity obliquely impacting surface plates.

KSC-08pd0671

NASA Image and Video Library

2008-03-10

KENNEDY SPACE CENTER, FLA. -- On Launch Pad 39A at NASA's Kennedy Space Center, rollback of the rotating service structure reveals space shuttle Endeavour atop the mobile launcher platform. First motion was at 8:23 a.m. and rollback was complete at 8:55 a.m. Above the orange external tank is seen the "beanie cap" at the end of the gaseous oxygen vent arm, extending from the fixed service structure. Vapors are created as the liquid oxygen in the external tank boil off. The hood vents the gaseous oxygen vapors away from the space shuttle vehicle. Below is the orbiter access arm with the White Room at the end, flush against the shuttle. The crew gains access into the orbiter through the White Room. On either side of the main engines and below the wings are the tail service masts, which provide several umbilical connections to the orbiter, including a liquid-oxygen line through one and a liquid-hydrogen line through another. The rotating structure provides protected access to the orbiter for changeout and servicing of payloads at the pad. The structure is supported by a rotating bridge that pivots about a vertical axis on the west side of the pad's flame trench. After the RSS is rolled back, the orbiter is ready for fuel cell activation and external tank cryogenic propellant loading operations. The pad is cleared to the perimeter gate for operations to fill the external tank with about 500,000 gallons of cryogenic propellants used by the shuttle’s main engines. This is done at the pad approximately eight hours before the scheduled launch. Endeavour and its crew will deliver the first section of the Japan Aerospace Exploration Agency's Kibo laboratory and the Canadian Space Agency's two-armed robotic system, Dextre. Launch is scheduled for 2:28 a.m. EDT March 11. Photo credit: NASA/Kim Shiflett

KSC-08pd0670

NASA Image and Video Library

2008-03-10

KENNEDY SPACE CENTER, FLA. -- On Launch Pad 39A at NASA's Kennedy Space Center, rollback of the rotating service structure (at left) reveals space shuttle Endeavour atop the mobile launcher platform. First motion was at 8:23 a.m. and rollback was complete at 8:55 a.m. Above the orange external tank is seen the "beanie cap" at the end of the gaseous oxygen vent arm, extending from the fixed service structure. Vapors are created as the liquid oxygen in the external tank boil off. The hood vents the gaseous oxygen vapors away from the space shuttle vehicle. Below is the orbiter access arm with the White Room at the end, flush against the shuttle. The crew gains access into the orbiter through the White Room. On either side of the main engines and below the wings are the tail service masts, which provide several umbilical connections to the orbiter, including a liquid-oxygen line through one and a liquid-hydrogen line through another. The rotating structure provides protected access to the orbiter for changeout and servicing of payloads at the pad. The structure is supported by a rotating bridge that pivots about a vertical axis on the west side of the pad's flame trench. After the RSS is rolled back, the orbiter is ready for fuel cell activation and external tank cryogenic propellant loading operations. The pad is cleared to the perimeter gate for operations to fill the external tank with about 500,000 gallons of cryogenic propellants used by the shuttle’s main engines. This is done at the pad approximately eight hours before the scheduled launch. Endeavour and its crew will deliver the first section of the Japan Aerospace Exploration Agency's Kibo laboratory and the Canadian Space Agency's two-armed robotic system, Dextre. Launch is scheduled for 2:28 a.m. EDT March 11. Photo credit: NASA/Kim Shiflett

Late Cenozoic deformation of the Eurasian and Burma Plates due to subduction of the Indian Plate beneath SE Tibetan Plateau and Myanmar

NASA Astrophysics Data System (ADS)

Ni, J.; Holt, W. E.; Flesch, L. M.; Sandvol, E. A.; Hearn, T. M.; Schmerr, N. C.

2015-12-01

The late Cenozoic tectonics of the southeastern Tibetan Plateau and surrounding regions needs to be evaluated within the context of a larger dynamic system related to the subduction of the Indian oceanic lithosphere beneath Myanmar and Yunnan. The details of the geodynamic processes involve mantle flows associated with rollback and tears (which probably occur both laterally and horizontally) of the Indian slab with consequent effects on the geology of the overriding plate. These effects include: 1) volcanism in Tongchong, Yunnan Province, 2) clockwise rotational deformation of the overriding plate and 3) Burma Plate capture. In this talk we will present the strain rate throughout the region with a moment tensor summation of earthquake data. The deformation of SE Tibet, Yunnan and western Sichuan constitutes a distributed N-S oriented dextral shear zone with clockwise rotations up to 1.7° per million years. It is the clockwise vorticity relative to south China that accounts for the relative northward motion of India at a rate of 38±12 mm/yr at the Himalayas. Relative to south China, there is no southeastward extrusion of crustal material beyond the eastern margin of the Tibetan Plateau. Studies on earthquake seismic moment data, fault-slip data, and GPS measurements all show a clockwise rotational motion of SE Tibet, Yunnan, western Sichuan and eastern Myanmar around the EHS. The mirror image of this situation that is occurring today is the counterclockwise rotation of Anatolia, which is associated with the rollback of the Hellenic and Cyprian Trenches. In this talk we will also discuss the extreme oblique convergence between Indian and Burma plates and one of the effects of the oblique subducation is the transfer of right-lateral strike-slip faulting to the Indo Burma Range, one of the largest GeoPRISMs on Earth.

Active and fossil mantle flows in the western Alpine region unravelled by seismic anisotropy analysis and high-resolution P wave tomography

NASA Astrophysics Data System (ADS)

Salimbeni, Simone; Malusà, Marco G.; Zhao, Liang; Guillot, Stéphane; Pondrelli, Silvia; Margheriti, Lucia; Paul, Anne; Solarino, Stefano; Aubert, Coralie; Dumont, Thierry; Schwartz, Stéphane; Wang, Qingchen; Xu, Xiaobing; Zheng, Tianyu; Zhu, Rixiang

2018-04-01

The anisotropy of seismic velocities in the mantle, when integrated with high-resolution tomographic models and geologic information, can be used to detect active mantle flows in complex plate boundary areas, providing new insights on the impact of mantle processes on the topography of mountain belts. Here we use a densely spaced array of temporary broadband seismic stations to analyze the seismic anisotropy pattern of the western Alpine region, at the boundary between the Alpine and Apenninic slabs. Our results are supportive of a polyphase development of anisotropic mantle fabrics, possibly starting from the Jurassic to present. Geophysical data presented in this work, and geologic evidence taken from the literature, indicate that: (i) fossil fabrics formed during Tethyan rifting may be still preserved within the Alpine and Apenninic slabs; (ii) mantle deformation during Apenninic slab rollback is not compensated by a complete toroidal flow around the northern tip of the retreating slab; (iii) the previously observed continuous trend of anisotropy fast axes near-parallel to the western Alpine arc is confirmed. We observe that this arc-parallel trend of fast axes is located in correspondence to a low velocity anomaly in the European upper mantle, beneath regions of the Western and Ligurian Alps showing the highest uplift rates. We propose that the progressive rollback of the Apenninic slab, in the absence of a counterclockwise toroidal flow at its northern tip, induced a suction effect at the scale of the supraslab mantle. The resulting mantle flow pattern was characterized by an asthenospheric counterflow at the rear of the unbroken Western Alps slab and around its southern tip, and by an asthenospheric upwelling, mirrored by low P wave velocities, that would have favored the topographic uplift of the Alpine belt from the Mont Blanc to the Mediterranean sea.

Preliminary Results From a Heavily Instrumented Engine Ice Crystal Icing Test in a Ground Based Altitude Test Facility

NASA Technical Reports Server (NTRS)

Flegel, Ashlie B.; Oliver, Michael J.

2016-01-01

Preliminary results from the heavily instrumented ALF502R-5 engine test conducted in the NASA Glenn Research Center Propulsion Systems Laboratory are discussed. The effects of ice crystal icing on a full scale engine is examined and documented. This same model engine, serial number LF01, was used during the inaugural icing test in the Propulsion Systems Laboratory facility. The uncommanded reduction of thrust (rollback) events experienced by this engine in flight were simulated in the facility. Limited instrumentation was used to detect icing on the LF01 engine. Metal temperatures on the exit guide vanes and outer shroud and the load measurement were the only indicators of ice formation. The current study features a similar engine, serial number LF11, which is instrumented to characterize the cloud entering the engine, detect/ characterize ice accretion, and visualize the ice accretion in the region of interest. Data were acquired at key LF01 test points and additional points that explored: icing threshold regions, low altitude, high altitude, spinner heat effects, and the influence of varying the facility and engine parameters. For each condition of interest, data were obtained from some selected variations of ice particle median volumetric diameter, total water content, fan speed, and ambient temperature. For several cases the NASA in-house engine icing risk assessment code was used to find conditions that would lead to a rollback event. This study further helped NASA develop necessary icing diagnostic instrumentation, expand the capabilities of the Propulsion Systems Laboratory, and generate a dataset that will be used to develop and validate in-house icing prediction and risk mitigation computational tools. The ice accretion on the outer shroud region was acquired by internal video cameras. The heavily instrumented engine showed good repeatability of icing responses when compared to the key LF01 test points and during day-to-day operation. Other noticeable observations are presented.

Preliminary Results From a Heavily Instrumented Engine Ice Crystal Icing Test in a Ground Based Altitude Test Facility

NASA Technical Reports Server (NTRS)

Flegel, Ashlie B.; Oliver, Michael J.

2016-01-01

Preliminary results from the heavily instrumented ALF502R-5 engine test conducted in the NASA Glenn Research Center Propulsion Systems Laboratory are discussed. The effects of ice crystal icing on a full scale engine is examined and documented. This same model engine, serial number LF01, was used during the inaugural icing test in the Propulsion Systems Laboratory facility. The uncommanded reduction of thrust (rollback) events experienced by this engine in flight were simulated in the facility. Limited instrumentation was used to detect icing on the LF01 engine. Metal temperatures on the exit guide vanes and outer shroud and the load measurement were the only indicators of ice formation. The current study features a similar engine, serial number LF11, which is instrumented to characterize the cloud entering the engine, detect/characterize ice accretion, and visualize the ice accretion in the region of interest. Data were acquired at key LF01 test points and additional points that explored: icing threshold regions, low altitude, high altitude, spinner heat effects, and the influence of varying the facility and engine parameters. For each condition of interest, data were obtained from some selected variations of ice particle median volumetric diameter, total water content, fan speed, and ambient temperature. For several cases the NASA in-house engine icing risk assessment code was used to find conditions that would lead to a rollback event. This study further helped NASA develop necessary icing diagnostic instrumentation, expand the capabilities of the Propulsion Systems Laboratory, and generate a dataset that will be used to develop and validate in-house icing prediction and risk mitigation computational tools. The ice accretion on the outer shroud region was acquired by internal video cameras. The heavily instrumented engine showed good repeatability of icing responses when compared to the key LF01 test points and during day-to-day operation. Other noticeable observations are presented.

New constraints on the mechanism for the formation of the Pannonian basin

NASA Astrophysics Data System (ADS)

Horváth, Ferenc; Fodor, László; Balázs, Attila; Musitz, Balázs; Koroknai, Balázs

2013-04-01

The epoch making cooperation with the MIT group (especially Wiki Royden) in the 1980's on the Pannonian basin arrived at two main conclusions: i) modest to medium value of synrift crustal extension was accompanied by dramatic attenuation of the mantle lithosphere, and ii) subduction and rollback of the Alpine Tethys controlled the extrusion of Alcapa and Tisza-Dacia terranes into the Carpathian embayment. These early results already went beyond a thermomechanical model and suggested the importance of dynamic influences exerted by upper mantle flows. Recent results of SKS anisotropy determinations (Kovács et al. 2012) has been interpreted in terms of a west-east directed flow sub-parallel with the main strike of the Eastern Alps at the western and central part of the basin, and a toroidal flow around the subducted Carpathian slab more towards the east. Horváth and Faccenna (2011) have put forward the idea that inflow of upper mantle material into the Pannonian basin was derived from the sub-Adriatic lithosphere via the northern Dinaric slab window since the late Oligocene, when rollback of oceanic lithosphere commenced on the western and eastern side of Adria. The importance of Dinaric subduction in the evolution of the Pannonian basin has been spectacularly demonstrated recently by the recognition of a number of metamorphic core complexes in the Sava-zone, which were exhumed during the synrift phase of the Pannonian basin (e.g. Ustaszewski et al. 2010, Matenco et al. 2012). Inside the basin the Sava zone represents a complex transfer fault system between the Alcapa and Tisza-Dacia terranes. High quality seismic sections will be presented with new interpretation to show the complicated structural features and the massive volcanism interpreted in terms of leaky transforms. The seismic sections will also show new time constraint for the postrift fill of the basin, which shed new light on the dramatically anomalous subsidence and uplift pattern during the late Miocene to Present history of the Pannonian basin.

Complex interactions between diapirs and 4-D subduction driven mantle wedge circulation.

NASA Astrophysics Data System (ADS)

Sylvia, R. T.; Kincaid, C. R.

2015-12-01

Analogue laboratory experiments generate 4-D flow of mantle wedge fluid and capture the evolution of buoyant mesoscale diapirs. The mantle is modeled with viscous glucose syrup with an Arrhenius type temperature dependent viscosity. To characterize diapir evolution we experiment with a variety of fluids injected from multiple point sources. Diapirs interact with kinematically induced flow fields forced by subducting plate motions replicating a range of styles observed in dynamic subduction models (e.g., rollback, steepening, gaps). Data is collected using high definition timelapse photography and quantified using image velocimetry techniques. While many studies assume direct vertical connections between the volcanic arc and the deeper mantle source region, our experiments demonstrate the difficulty of creating near vertical conduits. Results highlight extreme curvature of diapir rise paths. Trench-normal deflection occurs as diapirs are advected downward away from the trench before ascending into wedge apex directed return flow. Trench parallel deflections up to 75% of trench length are seen in all cases, exacerbated by complex geometry and rollback motion. Interdiapir interaction is also important; upwellings with similar trajectory coalesce and rapidly accelerate. Moreover, we observe a new mode of interaction whereby recycled diapir material is drawn down along the slab surface and then initiates rapid fluid migration updip along the slab-wedge interface. Variability in trajectory and residence time leads to complex petrologic inferences. Material from disparate source regions can surface at the same location, mix in the wedge, or become fully entrained in creeping flow adding heterogeneity to the mantle. Active diapirism or any other vertical fluid flux mechanism employing rheological weakening lowers viscosity in the recycling mantle wedge affecting both solid and fluid flow characteristics. Many interesting and insightful results have been presented based upon 2-D, steady-state thermal and flow regimes. We reiterate the importance of 4-D time evolution in subduction models. Analogue experiments allow added feedbacks and complexity improving intuition and providing insight for further investigation.

Lithosphere and Asthenosphere Structure of the Western Mediterranean and Northwest Africa from Rayleigh Wave tomography and Ps Receiver Functions

NASA Astrophysics Data System (ADS)

Palomeras, Imma; Thurner, Sally; Levander, Alan; Bezada, Maximiliano; Villasenor, Antonio; Humphreys, Eugene; Carbonell, Ramon; Gallart, Josep

2013-04-01

Since Cenozoic times the Western Mediterranean has been affected by complex subduction and slab rollback, during African-European convergence. The deformed region occupies a wide area from the Atlas mountains in northwest Africa to the southern Iberian Massif in Spain. Evolutionary models of the Western Mediterranean invoke extensive slab rollback and compression, as well as likely upper mantle delamination/convective drip scenarios during formation of the Alboran domain, the Betics, Rif, and Atlas Mountains. We report on a multidisciplinary, international investigation of the Alboran System and surrounding areas. In this study we have analyzed teleseismic data from the roughly 240 temporary and permanent broadband seismographs operated in this region by more than a dozen different cooperating research groups. Here we present combined results from Rayleigh wave tomography and Ps receiver functions. Receiver functions were made in 3 frequency bands (2 Hz, 1 Hz, 0.5 Hz) using iterative time-domain and water-level frequency-domain methods. We measured Rayleigh phase velocities using the two-plane-wave method and finite-frequency kernels to remove complications due to multi-pathing and to improve lateral resolution, respectively. The resulting 3D shear velocity model was used to create 3D image volumes of the Ps receiver functions. The RF and tomography images are consistent with one another and withteleseismic body wave tomography (Bezada et al., submitted) Our results show high velocities from ~70 km to 230 km depth in an elliptical area just west of the Gibraltar straits which is interpreted as a near vertical slab beneath the Alboran Domain and the adjacent Spanish continental margin. The surface wave results map out the top of a 600+ km deep nearly vertical slab seen in the P body wave tomography. The RF images suggest that the top of this slab is still attached to the Alboran domain Moho beneath Gibraltar, a complex region where lower crustal velocities (

On the potential asthenospheric linkage between Apenninic slab rollback and Alpine topographic uplift: insights from P wave tomography and seismic anisotropy analysis

NASA Astrophysics Data System (ADS)

Malusa', Marco Giovanni; Salimbeni, Simone; Zhao, Liang; Guillot, Stéphane; Pondrelli, Silvia; Margheriti, Lucia; Paul, Anne; Solarino, Stefano; Aubert, Coralie; Dumont, Thierry; Schwartz, Stéphane; Wang, Qingchen; Xu, Xiaobing; Zheng, Tianyu; Zhu, Rixiang

2017-04-01

The role of surface and deep-seated processes in controlling the topography of complex plate-boundary areas is a highly debated issue. In the Western Alps, which include the highest summits in Europe, factors controlling topographic uplift still remain poorly understood. In the absence of active convergence, recent works have suggested a potential linkage between slab breakoff and fast uplift, but this hypothesis is ruled out by the down-dip continuity of the Alpine slab documented by recent tomographic images of the upper mantle beneath the Alpine region (Zhao et al. 2016). In order to shed light on this issue, we use a densely spaced array of temporary broadband seismic stations and previously published observations to analyze the seismic anisotropy pattern along the transition zone between the Alps and the Apennines, within the framework of the upper mantle structure unveiled by P wave tomography. Our results show a continuous trend of anisotropy fast axes near-parallel to the western alpine arc, possibly due to an asthenospheric counterflow triggered by the eastward retreat of the Apenninic slab. This trend is located in correspondence of a low velocity anomaly in the European upper mantle, and beneath the Western Alps region characterized by the highest uplift rates, which may suggest a potential impact of mantle dynamics on Alpine topography. We propose that the progressive rollback of the Apenninic slab induced a suction effect and an asthenospheric counterflow at the rear of the unbroken Alpine slab and around its southern tip, as well as an asthenospheric upwelling, mirrored by low P wave velocities, which may have favored the topographic uplift of the Alpine belt from the Mt Blanc to the Ligurian coast. Zhao L. et al., 2016. Continuity of the Alpine slab unraveled by high-resolution P wave tomography. J. Geophys. Res., doi:10.1002/2016JB013310.

Seismic anisotropy in the Hellenic subduction zone: Effects of slab segmentation and subslab mantle flow

NASA Astrophysics Data System (ADS)

Evangelidis, C. P.

2017-12-01

The segmentation and differentiation of subducting slabs have considerable effects on mantle convection and tectonics. The Hellenic subduction zone is a complex convergent margin with strong curvature and fast slab rollback. The upper mantle seismic anisotropy in the region is studied focusing at its western and eastern edges in order to explore the effects of possible slab segmentation on mantle flow and fabrics. Complementary to new SKS shear-wave splitting measurements in regions not adequately sampled so far, the source-side splitting technique is applied to constrain the depth of anisotropy and to densify measurements. In the western Hellenic arc, a trench-normal subslab anisotropy is observed near the trench. In the forearc domain, source-side and SKS measurements reveal a trench-parallel pattern. This indicates subslab trench-parallel mantle flow, associated with return flow due to the fast slab rollback. The passage from continental to oceanic subduction in the western Hellenic zone is illustrated by a forearc transitional anisotropy pattern. This indicates subslab mantle flow parallel to a NE-SW smooth ramp that possibly connects the two subducted slabs. A young tear fault initiated at the Kefalonia Transform Fault is likely not entirely developed, as this trench-parallel anisotropy pattern is observed along the entire western Hellenic subduction system, even following this horizontal offset between the two slabs. At the eastern side of the Hellenic subduction zone, subslab source-side anisotropy measurements show a general trench-normal pattern. These are associated with mantle flow through a possible ongoing tearing of the oceanic lithosphere in the area. Although the exact geometry of this slab tear is relatively unknown, SKS trench-parallel measurements imply that the tear has not reached the surface yet. Further exploration of the Hellenic subduction system is necessary; denser seismic networks should be deployed at both its edges in order to achieve a more definite image of the structure and geodynamics of this area.

Slab dragging and the recent geodynamic evolution of the western Mediterranean plate boundary region

NASA Astrophysics Data System (ADS)

Spakman, Wim; Chertova, Maria V.; van den Berg, Arie P.; Thieulot, Cedric; van Hinsbergen, Douwe J. J.

2016-04-01

The Tortonian-Present geodynamic evolution of the plate boundary between North Africa and Iberia is characterized by first-order enigmas. This concerns, e.g., the diffuse tectonic activity of the plate boundary; the crustal thickening below the Rif; the closing of the northern Moroccan marine gateways prior to the Messinian Salinity Crisis; crustal extension of the central to eastern Betics; the origin and sense of motion of the large left-lateral Trans Alboran Shear Zone (TASZ) and Eastern Betic Shear Zone (EBSZ); and lithosphere delamination of the North African continental edge. Many explanations have been given for each of these seemingly disparate tectonic features, which invariably have been addressed in the plate tectonic context of the NW-SE relative plate convergence between the major plates since the Tortonian, mostly independently from each other. Usually there is no clear role for the subducted slab underlying the region, except for presumed rollback, either to SW or to the W, depending on the type of observations that require explanation. Here we integrate the dynamic role of the slab with the NW-SE relative plate convergence by 3-D numerical modelling of the slab evolution constrained by absolute plate motions (Chertova et al., JGR,2014 & Gcubed 2014). By combining observations and predictions from seismology, geology, and geodesy, with our numerical 3-D slab-mantle dynamics modelling, we developed a new and promising geodynamic framework that provides explanations of all noted tectonic enigmas in a coherent and connected way. From the Tortonian until today, we propose that mantle-resisted slab dragging combines with the NW-SE plate convergence across the (largely) unbroken plate boundary to drive the crustal deformation of the region. Slab dragging is the lateral transport, pushing or pulling, of slab through the mantle by the absolute motion of the subducting plate (Chertova et al., Gcubed, 2014). Because the slab is connected to both the Iberian and African lithosphere, both plates are dragging the slab by their shared ~NNE component of absolute plate motion, which in fact is invisible in the relative plate convergence frame that is usually adopted. Slab dragging induces mantle resistance that, we demonstrate by numerical modelling, leads in the region to differential lateral motion between the slab and African plate driving indentation of the Africa continental lithosphere leading to crustal shortening explaining the closure of Moroccan seaways and the thickening of the Rif crust. The differential motion also explains the TASZ and the transition from western Betics shortening to eastern Betics extension, both still active today. During Miocene westward slab rollback mantle-resisted slab dragging also provided the driving force of edge delamination of African lithosphere, we propose. These explanations of geological features are fully corroborates by an analysis of the GPS motion field in terms of the strain- and rotation rate fields using the method of Spakman and Nyst (2002), and the predicted crustal flow field. In particular, we derive from the GPS and geological data that the direction of African absolute motion is ~NNE and that the slab experiences at present negligible rollback.

A plate-driven model for enigmatic volcanic history of the Cascades-Yellowstone System

NASA Astrophysics Data System (ADS)

Szwaja, S.; Kincaid, C. R.; Druken, K. A.; MacDougall, J.

2013-12-01

The Cascades subduction system in the Pacific Northwest (USA) represents a complex tectonic setting, where rollback subduction of the Juan de Fuca plate beneath the North American plate, back-arc extension, and a possible mantle plume have been proposed to explain the complicated volcanic trends observed over the past 20 Ma. Plume and non-plume models have been developed to reconcile the voluminous Columbia River/Steens Flood Basalts (CSFB) (~20 Ma), the age progressive (15 Ma to present) Snake River Plain (SRP) that terminates at Yellowstone and the opposite, or westward trending High Lava Plains (HLP) volcanic track of eastern/central Oregon. We present results from laboratory experiments designed to test a plate-driven model for reproducing gross spatial-temporal characteristics of these three magmatic features. Models use a glucose fluid with temperature dependent viscosity in representing Earth's mantle and continuous rubber belts that kinematically reproduce subduction trends for the Cascades system. Experiments begin at 20 Ma with a volume of mantle residuum in the Cascades wedge that is elongated and restricted in the trench-parallel and trench-normal directions, respectively. The underlying assumption is that residuum was created in the wedge during an earlier plate steepening event that caused the flood basalts. Our models characterize dispersion patterns for the melt residuum material as it deforms within four-dimensional wedge circulation fields driven by rollback subduction (e.g. with a translational component of motion). Results show that residuum viscosity, relative to the ambient fluid, determines whether anomalous fluid can evolve to a morphology that matches the SRP/HLP tracks over ~15-20Ma. A weak residuum (e.g. retained partial melt) deforms over this time scale from the initial north-south oriented feature to an east-west trending morphology that is thin in both depth and north-south extent, material initially beneath CSFB is offset to the south, and is capable of producing opposite age progressions beneath the surface HLP/SRP track locations. The evolution of a high viscosity residuum in rollback-driven flow did not match the observed trends, as the feature deformed into an overly thick and wide morphology in the sub-HLP wedge compared to seismic data. Higher viscosity also produces stress coupling throughout the residuum, causing efficient entrainment from under the SRP towards the trench, leaving only ambient fluid beneath this track. In cases with stronger viscous coupling to the base of the overriding plate, the residuum is not able to deform into a morphology that is consistent with SRP/HLP tracks over the period 15 - 0 Ma. Models show only a limited range of conditions, where a low viscosity residuum is decoupled from the overriding plate, are capable of producing morphologies and offsets that roughly match observed spatial and temporal trends for primary features in the Pacific Northwest. Additional work is needed to understand the vertical heat/mass transfer processes that would enable deforming residuum to continually supply the bimodal magmatic output recorded over ~15Ma along the HLP and SRP tracks.

Deconstructing spatiotemporal chaos using local symbolic dynamics.

PubMed

Pethel, Shawn D; Corron, Ned J; Bollt, Erik

2007-11-23

We find that the global symbolic dynamics of a diffusively coupled map lattice is well approximated by a very small local model for weak to moderate coupling strengths. A local symbolic model is a truncation of the full symbolic model to one that considers only a single element and a few neighbors. Using interval analysis, we give rigorous results for a range of coupling strengths and different local model widths. Examples are presented of extracting a local symbolic model from data and of controlling spatiotemporal chaos.

Altered skin flowmotion in hypertensive humans

PubMed Central

Bruning, R.S.; Kenney, W.L.; Alexander, L.M.

2017-01-01

Essential hypertensive humans exhibit attenuated cutaneous nitric oxide (NO)-dependent vasodilation. Using spectral analysis (fast Fourier transformation) we aimed to characterize the skin flowmotion contained in the laser-Doppler flowmetry recordings during local heating-induced vasodilation before and after concurrent pharmacological inhibition of nitric oxide synthase (NOS) in hypertensive and age-matched normotensive men and women. We hypothesized that hypertensive subjects would have lower total power spectral densities (PSD), specifically in the frequency intervals associated with intrinsic endothelial and neurogenic control of the microvasculature. Furthermore, we hypothesized that NOS inhibition would attenuate the endothelial frequency interval. Laser-Doppler flowmetry recordings during local heating experiments from 18 hypertensive (MAP: 108±2mmHg) and 18 normotensive (MAP: 88±2mmHg) men and women were analyzed. Within site NO-dependent vasodilation was assessed by perfusion of a non-specific NOS inhibitor (NG-nitro-L-arginine methyl ester; L-NAME) through intradermal microdialysis during the heating-induced plateau in skin blood flow. Local heating-induced vasodilation increased total PSD for all frequency intervals (all p<0.001). Hypertensives had a lower total PSD (p=0.03) and absolute neurogenic frequency intervals (p<0.01) compared to the normotensives. When normalized as a percentage of total PSD, hypertensives had reduced neurogenic (p<0.001) and augmented myogenic contributions (p=0.04) to the total spectrum. NOS inhibition decreased total PSD (p<0.001) for both groups, but hypertensives exhibited lower absolute endothelial (p<0.01), neurogenic (p<0.05), and total PSD (p<0.001) frequency intervals compared to normotensives. These data suggest that essential hypertension results in altered neurogenic and NOS-dependent control of skin flowmotion and support the use of spectral analysis as a non-invasive technique to study vasoreactivity. PMID:24418051

Comparison of WBRT alone, SRS alone, and their combination in the treatment of one or more brain metastases: Review and meta-analysis.

PubMed

Khan, Muhammad; Lin, Jie; Liao, Guixiang; Li, Rong; Wang, Baiyao; Xie, Guozhu; Zheng, Jieling; Yuan, Yawei

2017-07-01

Whole brain radiotherapy has been a standard treatment of brain metastases. Stereotactic radiosurgery provides more focal and aggressive radiation and normal tissue sparing but worse local and distant control. This meta-analysis was performed to assess and compare the effectiveness of whole brain radiotherapy alone, stereotactic radiosurgery alone, and their combination in the treatment of brain metastases based on randomized controlled trial studies. Electronic databases (PubMed, MEDLINE, Embase, and Cochrane Library) were searched to identify randomized controlled trial studies that compared treatment outcome of whole brain radiotherapy and stereotactic radiosurgery. This meta-analysis was performed using the Review Manager (RevMan) software (version 5.2) that is provided by the Cochrane Collaboration. The data used were hazard ratios with 95% confidence intervals calculated for time-to-event data extracted from survival curves and local tumor control rate curves. Odds ratio with 95% confidence intervals were calculated for dichotomous data, while mean differences with 95% confidence intervals were calculated for continuous data. Fixed-effects or random-effects models were adopted according to heterogeneity. Five studies (n = 763) were included in this meta-analysis meeting the inclusion criteria. All the included studies were randomized controlled trials. The sample size ranged from 27 to 331. In total 202 (26%) patients with whole brain radiotherapy alone, 196 (26%) patients receiving stereotactic radiosurgery alone, and 365 (48%) patients were in whole brain radiotherapy plus stereotactic radiosurgery group. No significant survival benefit was observed for any treatment approach; hazard ratio was 1.19 (95% confidence interval: 0.96-1.43, p = 0.12) based on three randomized controlled trials for whole brain radiotherapy only compared to whole brain radiotherapy plus stereotactic radiosurgery and hazard ratio was 1.03 (95% confidence interval: 0.82-1.29, p = 0.81) for stereotactic radiosurgery only compared to combined approach. Local control was best achieved when whole brain radiotherapy was combined with stereotactic radiosurgery. Hazard ratio 2.05 (95% confidence interval: 1.36-3.09, p = 0.0006) and hazard ratio 1.84 (95% confidence interval: 1.26-2.70, p = 0.002) were obtained from comparing whole brain radiotherapy only and stereotactic radiosurgery only to whole brain radiotherapy + stereotactic radiosurgery, respectively. No difference in adverse events for treatment difference; odds ratio 1.16 (95% confidence interval: 0.77-1.76, p = 0.48) and odds ratio 0.92 (95% confidence interval: 0.59-1.42, p = 71) for whole brain radiotherapy + stereotactic radiosurgery versus whole brain radiotherapy only and whole brain radiotherapy + stereotactic radiosurgery versus stereotactic radiosurgery only, respectively. Adding stereotactic radiosurgery to whole brain radiotherapy provides better local control as compared to whole brain radiotherapy only and stereotactic radiosurgery only with no difference in radiation related toxicities.

STS-84 Atlantis on Pad 39-A after RSS roll back

NASA Technical Reports Server (NTRS)

1997-01-01

News media representatives watch and record as the Space Shuttle Atlantis in full launch configuration is revealed after the Rotating Service Structure (RSS) is rotated back at Launch Pad 39A. Rollback of the RSS is a major preflight milestone, typically occurring during the T-11-hour hold on L-1 (the day before launch). Atlantis and its crew of seven are in final preparations for liftoff on Mission STS-84, the sixth of nine planned dockings of the Space Shuttle with the Russian Space Station Mir. Launch is scheduled at about 4:08 a.m. during an approximately 7-minute launch window. The exact liftoff time will be determined about 90 minutes prior to launch, based on the most current location of Mir.

New-Sum: A Novel Online ABFT Scheme For General Iterative Methods

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tao, Dingwen; Song, Shuaiwen; Krishnamoorthy, Sriram

Emerging high-performance computing platforms, with large component counts and lower power margins, are anticipated to be more susceptible to soft errors in both logic circuits and memory subsystems. We present an online algorithm-based fault tolerance (ABFT) approach to efficiently detect and recover soft errors for general iterative methods. We design a novel checksum-based encoding scheme for matrix-vector multiplication that is resilient to both arithmetic and memory errors. Our design decouples the checksum updating process from the actual computation, and allows adaptive checksum overhead control. Building on this new encoding mechanism, we propose two online ABFT designs that can effectively recovermore » from errors when combined with a checkpoint/rollback scheme.« less

Low cost management of replicated data in fault-tolerant distributed systems

NASA Technical Reports Server (NTRS)

Joseph, Thomas A.; Birman, Kenneth P.

1990-01-01

Many distributed systems replicate data for fault tolerance or availability. In such systems, a logical update on a data item results in a physical update on a number of copies. The synchronization and communication required to keep the copies of replicated data consistent introduce a delay when operations are performed. A technique is described that relaxes the usual degree of synchronization, permitting replicated data items to be updated concurrently with other operations, while at the same time ensuring that correctness is not violated. The additional concurrency thus obtained results in better response time when performing operations on replicated data. How this technique performs in conjunction with a roll-back and a roll-forward failure recovery mechanism is also discussed.

Integrated analysis of error detection and recovery

NASA Technical Reports Server (NTRS)

Shin, K. G.; Lee, Y. H.

1985-01-01

An integrated modeling and analysis of error detection and recovery is presented. When fault latency and/or error latency exist, the system may suffer from multiple faults or error propagations which seriously deteriorate the fault-tolerant capability. Several detection models that enable analysis of the effect of detection mechanisms on the subsequent error handling operations and the overall system reliability were developed. Following detection of the faulty unit and reconfiguration of the system, the contaminated processes or tasks have to be recovered. The strategies of error recovery employed depend on the detection mechanisms and the available redundancy. Several recovery methods including the rollback recovery are considered. The recovery overhead is evaluated as an index of the capabilities of the detection and reconfiguration mechanisms.

STS-35 Columbia, OV-102, rolls back to KSC VAB after hydrogen leak discovered

NASA Image and Video Library

1990-06-12

S90-42289 ( 3 July 1990) --- Kennedy Space Center (KSC) workers watch as Columbia, Orbiter Vehicle (OV) 102, along with its external tank (ET) and two solid rocket boosters (SRBs) atop the giant crawler transporter, rolls back to KSC's Vehicle Assembly Building (VAB). The rollback was caused by a hydrogen leak that stopped the STS-35 countdown during ET fueling, 05-29-90. Once in the VAB, OV-102 and its stack will be demated, and OV-102, with its Astronomy Laboratory 1 (ASTRO-1) payload aboard, will be moved to the Orbiter Processing Facility (OPF) to await return to KSC Launch Complex (LC) Pad 39A. View provided by KSC with alternate number KSC-90PC-901.

After tower rollback, the Boeing Delta II rocket with Mars Polar Lander aboard is ready for liftoff

NASA Technical Reports Server (NTRS)

1999-01-01

After launch tower retraction, the Boeing Delta II rocket carrying NASA's Mars Polar lander waits for liftoff, scheduled for 3:21 p.m. EST, at Launch Complex 17B, Cape Canaveral Air Station. The lander is a solar-powered spacecraft designed to touch down on the Martian surface near the northern-most boundary of the south pole in order to study the water cycle there. The lander also will help scientists learn more about climate change and current resources on Mars, studying such things as frost, dust, water vapor and condensates in the Martian atmosphere. It is the second spacecraft to be launched in a pair of Mars Surveyor 98 missions.

KSC-08pd1619

NASA Image and Video Library

2008-06-11

CAPE CANAVERAL, Fla. -- NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft atop the Delta II rocket is spotlighted after rollback of the mobile service tower on Cape Canaveral Air Force Station's Launch Pad 17-B. GLAST is a powerful space observatory that will explore the universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Launch is scheduled for 11:45 a.m. June 11. Photo credit: NASA/Dimitri Gerondidakis

A model-based approach to wildland fire reconstruction using sediment charcoal records

USGS Publications Warehouse

Itter, Malcolm S.; Finley, Andrew O.; Hooten, Mevin B.; Higuera, Philip E.; Marlon, Jennifer R.; Kelly, Ryan; McLachlan, Jason S.

2017-01-01

Lake sediment charcoal records are used in paleoecological analyses to reconstruct fire history, including the identification of past wildland fires. One challenge of applying sediment charcoal records to infer fire history is the separation of charcoal associated with local fire occurrence and charcoal originating from regional fire activity. Despite a variety of methods to identify local fires from sediment charcoal records, an integrated statistical framework for fire reconstruction is lacking. We develop a Bayesian point process model to estimate the probability of fire associated with charcoal counts from individual-lake sediments and estimate mean fire return intervals. A multivariate extension of the model combines records from multiple lakes to reduce uncertainty in local fire identification and estimate a regional mean fire return interval. The univariate and multivariate models are applied to 13 lakes in the Yukon Flats region of Alaska. Both models resulted in similar mean fire return intervals (100–350 years) with reduced uncertainty under the multivariate model due to improved estimation of regional charcoal deposition. The point process model offers an integrated statistical framework for paleofire reconstruction and extends existing methods to infer regional fire history from multiple lake records with uncertainty following directly from posterior distributions.

Characterization of minimal sequences associated with self-similar interval exchange maps

NASA Astrophysics Data System (ADS)

Cobo, Milton; Gutiérrez-Romo, Rodolfo; Maass, Alejandro

2018-04-01

The construction of affine interval exchange maps (IEMs) with wandering intervals that are semi-conjugate to a given self-similar IEM is strongly related to the existence of the so-called minimal sequences associated with local potentials, which are certain elements of the substitution subshift arising from the given IEM. In this article, under the condition called unique representation property, we characterize such minimal sequences for potentials coming from non-real eigenvalues of the substitution matrix. We also give conditions on the slopes of the affine extensions of a self-similar IEM that determine whether it exhibits a wandering interval or not.

76 FR 60789 - Local Number Portability Porting Interval and Validation Requirements; Telephone Number Portability

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-30

... (NANC) recommending a set of standard thresholds and intervals for non-simple ports and ``projects... comment on whether the thresholds and processing timelines for non-simple ports and projects are...: Interested parties may submit comments, identified by WC Docket No. 07-244 and CC Docket No. 95-116, by any...

'Where' and 'what' in visual search.

PubMed

Atkinson, J; Braddick, O J

1989-01-01

A line segment target can be detected among distractors of a different orientation by a fast 'preattentive' process. One view is that this depends on detection of a 'feature gradient', which enables subjects to locate where the target is without necessarily identifying what it is. An alternative view is that a target can be identified as distinctive in a particular 'feature map' without subjects knowing where it is in that map. Experiments are reported in which briefly exposed arrays of line segments were followed by a pattern mask, and the threshold stimulus-mask interval determined for three tasks: 'what'--subjects reported whether the target was vertical or horizontal among oblique distractors; 'coarse where'--subjects reported whether the target was in the upper or lower half of the array; 'fine where'--subjects reported whether or not the target was in a set of four particular array positions. The threshold interval was significantly lower for the 'coarse where' than for the 'what' task, indicating that, even though localization in this task depends on the target's orientation difference, this localization is possible without absolute identification of target orientation. However, for the 'fine where' task, intervals as long as or longer than those for the 'what' task were required. It appears either that different localization processes work at different levels of resolution, or that a single localization process, independent of identification, can increase its resolution at the expense of processing speed. These possibilities are discussed in terms of distinct neural representations of the visual field and fixed or variable localization processes acting upon them.

Plume-stagnant slab-lithosphere interactions: Origin of the late Cenozoic intra-plate basalts on the East Eurasia margin

NASA Astrophysics Data System (ADS)

Kimura, Jun-Ichi; Sakuyama, Tetsuya; Miyazaki, Takashi; Vaglarov, Bogdan S.; Fukao, Yoshio; Stern, Robert J.

2018-02-01

Intra-plate basalts of 35-0 Ma in East Eurasia formed in a broad backarc region above the stagnant Pacific Plate slab in the mantle transition zone. These basalts show regional-scale variations in Nd-Hf isotopes. The basalts with the most radiogenic Nd-Hf center on the Shandong Peninsula with intermediate Nd-Hf at Hainan and Datong. The least radiogenic basalts occur in the perimeters underlain by the thick continental lithosphere. Shandong basalts possess isotopic signatures of the young igneous oceanic crust of the subducted Pacific Plate. Hainan and Datong basalts have isotopic signatures of recycled subduction materials with billions of years of storage in the mantle. The perimeter basalts have isotopic signatures similar to pyroxenite xenoliths from the subcontinental lithospheric mantle beneath East Eurasia. Hainan basalts exhibit the highest mantle potential temperature (Tp), while the Shandong basalts have the lowest Tp. We infer that a deep high-Tp plume interacted with the subducted Pacific Plate slab in the mantle transition zone to form a local low-Tp plume by entraining colder igneous oceanic lithosphere. We infer that the subducted Izanagi Plate slab, once a part of the Pacific Plate mosaic, broke off from the Pacific Plate slab at 35 Ma to sink into the lower mantle. The sinking Izanagi slab triggered the plume that interacted with the stagnant Pacific slab and caused subcontinental lithospheric melting. This coincided with formation of the western Pacific backarc marginal basins due to Pacific Plate slab rollback and stagnation.

Hydrocarbons in New Guinea, controlled by basement fabric, Mesozoic extension and Tertiary convergent margin tectonics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hill, K.C.; Kendrick, R.D.; Crowhurst, P.V.

1996-01-01

Most models for the tectonic evolution of New Guinea involve Early and Late Miocene arc-continent collisions, creating an orogenic belt. Structural trends and prospectivity are then analyzed in terms of belts across the country; the Fold Belt (with the discovered oil and gas fields), the Mobile Belt and the accreted arcs. This model inhibits realistic assessment of prospectivity. It now appears the Mobile Belt formed by Oligocene compression then by Early Miocene extension, related to slab-rollback, that unroofed metamorphic core complexes adjacent to starved half-grabens. The grabens filled in the Middle Miocene and were largely transported intact during the Pliocenemore » arc-collision. Early Miocene reefs and hypothesized starved basin source rocks create a viable play throughout northern New Guinea as in the Salawati Basin. The Pliocene clastic section is locally prospective due to overthrusting and deep burial. Within the Fold Belt, the site and types of oil and gas fields are largely controlled by the basement architecture. This controlled the transfer zones and depocentres during Mesozoic extension and the location of major basement uplifts during compression. In PNG, the Bosavi lineament separates an oil province from a gas province. In Irian Jaya the transition from a relatively competent sequence to a rifted sequence west of [approx]139[degrees]E may also be a gas-oil province boundary. Understanding, in detail, the compartmentalization of inverted blocks and areas of thin-skinned thrusting, controlled by the basement architecture, will help constrain hydrocarbon prospectivity.« less

Hydrocarbons in New Guinea, controlled by basement fabric, Mesozoic extension and Tertiary convergent margin tectonics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hill, K.C.; Kendrick, R.D.; Crowhurst, P.V.

1996-12-31

Most models for the tectonic evolution of New Guinea involve Early and Late Miocene arc-continent collisions, creating an orogenic belt. Structural trends and prospectivity are then analyzed in terms of belts across the country; the Fold Belt (with the discovered oil and gas fields), the Mobile Belt and the accreted arcs. This model inhibits realistic assessment of prospectivity. It now appears the Mobile Belt formed by Oligocene compression then by Early Miocene extension, related to slab-rollback, that unroofed metamorphic core complexes adjacent to starved half-grabens. The grabens filled in the Middle Miocene and were largely transported intact during the Pliocenemore » arc-collision. Early Miocene reefs and hypothesized starved basin source rocks create a viable play throughout northern New Guinea as in the Salawati Basin. The Pliocene clastic section is locally prospective due to overthrusting and deep burial. Within the Fold Belt, the site and types of oil and gas fields are largely controlled by the basement architecture. This controlled the transfer zones and depocentres during Mesozoic extension and the location of major basement uplifts during compression. In PNG, the Bosavi lineament separates an oil province from a gas province. In Irian Jaya the transition from a relatively competent sequence to a rifted sequence west of {approx}139{degrees}E may also be a gas-oil province boundary. Understanding, in detail, the compartmentalization of inverted blocks and areas of thin-skinned thrusting, controlled by the basement architecture, will help constrain hydrocarbon prospectivity.« less

Topography of the overriding plate during progressive subduction: A dynamic model to explain forearc subsidence

NASA Astrophysics Data System (ADS)

Chen, Z.; Schellart, W. P.; Duarte, J. C.; Strak, V.

2017-12-01

Topography that forms at the free top surface of the lithosphere contains important information about the dynamics of the tectonic plates and the sub-lithospheric mantle. Investigating topography around subduction zones can provide quantitative and conceptual insights into the interaction between the plates, the slabs, mantle flow, and the associated stresses. To achieve this, geodynamic modelling can be an effective tool. In this study, we used techniques of stereoscopic photogrammetry and Particle Image Velocimetry to monitor simultaneously the topography of the overriding plate and the velocity field of the subduction-induced mantle flow occurring in the mantle wedge. Model results show that the overriding plate topography is characterized by an area of forearc topographic subsidence, with a magnitude scaling to 1.44-3.97 km in nature, and a transient local topographic high located between the forearc depression and the trench. These topographic features rapidly develop during the slab sinking phase and gradually decrease during the slab rollback phase. We propose that these topographic transient features predominantly result from the variation of the vertical component of the trench suction along the subduction zone interface, which is minimum near the trench and maximum near the tip of the mantle wedge and is caused by the gradual slab steepening during the initial transient slab sinking phase. The downward mantle flow in the nose of the mantle wedge plays a minor role in the formation of the forearc subsidence. Our findings provide a new mechanism for the formation of forearc topographic subsidence, which has been commonly observed at natural subduction zones.

Raising the Gangdese Mountains in southern Tibet

NASA Astrophysics Data System (ADS)

Zhu, Di-Cheng; Wang, Qing; Cawood, Peter A.; Zhao, Zhi-Dan; Mo, Xuan-Xue

2017-01-01

The surface uplift of mountain belts is in large part controlled by the effects of crustal thickening and mantle dynamic processes (e.g., lithospheric delamination or slab breakoff). Understanding the history and driving mechanism of uplift of the southern Tibetan Plateau requires accurate knowledge on crustal thickening over time. Here we determine spatial and temporal variations in crustal thickness using whole-rock La/Yb ratios of intermediate intrusive rocks from the Gangdese arc. Our results show that the crust was likely of normal thickness prior to approximately 70 Ma ( 37 km) but began to thicken locally at approximately 70-60 Ma. The crust reached (58-50) ± 10 km at 55-45 Ma extending over 400 km along the strike of the arc. This thickening was likely due to magmatic underplating as a consequence of rollback and then breakoff of the subducting Neo-Tethyan slab. The crust attained a thickness of 68 ± 12 km at approximately 20-10 Ma, as a consequence of underthrusting of India and associated thrust faulting. The Gangdese Mountains in southern Tibet broadly attained an elevation of >4000 m at approximately 55-45 Ma as a result of isostatic surface uplift driven by crustal thickening and slab breakoff and reached their present-day elevation by 20-10 Ma. Our paleoelevation estimates are consistent not only with the C-O isotope-based paleoaltimetry but also with the carbonate-clumped isotope paleothermometer, exemplifying the promise of reconstructing paleoelevation in time and space for ancient orogens through a combination of magmatic composition and Airy isostatic compensation.

The Effects of a Local Negative Feedback Function between Choice and Relative Reinforcer Rate

ERIC Educational Resources Information Center

Davison, Michael; Elliffe, Douglas; Marr, M. Jackson

2010-01-01

Four pigeons were trained on two-key concurrent variable-interval schedules with no changeover delay. In Phase 1, relative reinforcers on the two alternatives were varied over five conditions from 0.1 to 0.9. In Phases 2 and 3, we instituted a molar feedback function between relative choice in an interreinforcer interval and the probability of…

Fear conditioning is associated with dynamic directed functional interactions between and within the human amygdala, hippocampus, and frontal lobe.

PubMed

Liu, C C; Crone, N E; Franaszczuk, P J; Cheng, D T; Schretlen, D S; Lenz, F A

2011-08-25

The current model of fear conditioning suggests that it is mediated through modules involving the amygdala (AMY), hippocampus (HIP), and frontal lobe (FL). We now test the hypothesis that habituation and acquisition stages of a fear conditioning protocol are characterized by different event-related causal interactions (ERCs) within and between these modules. The protocol used the painful cutaneous laser as the unconditioned stimulus and ERC was estimated by analysis of local field potentials recorded through electrodes implanted for investigation of epilepsy. During the prestimulus interval of the habituation stage FL>AMY ERC interactions were common. For comparison, in the poststimulus interval of the habituation stage, only a subdivision of the FL (dorsolateral prefrontal cortex, dlPFC) still exerted the FL>AMY ERC interaction (dlFC>AMY). For a further comparison, during the poststimulus interval of the acquisition stage, the dlPFC>AMY interaction persisted and an AMY>FL interaction appeared. In addition to these ERC interactions between modules, the results also show ERC interactions within modules. During the poststimulus interval, HIP>HIP ERC interactions were more common during acquisition, and deep hippocampal contacts exerted causal interactions on superficial contacts, possibly explained by connectivity between the perihippocampal gyrus and the HIP. During the prestimulus interval of the habituation stage, AMY>AMY ERC interactions were commonly found, while interactions between the deep and superficial AMY (indirect pathway) were independent of intervals and stages. These results suggest that the network subserving fear includes distributed or widespread modules, some of which are themselves "local networks." ERC interactions between and within modules can be either static or change dynamically across intervals or stages of fear conditioning. Copyright © 2011 IBRO. Published by Elsevier Ltd. All rights reserved.

Dynamical Localization for Discrete and Continuous Random Schrödinger Operators

NASA Astrophysics Data System (ADS)

Germinet, F.; De Bièvre, S.

We show for a large class of random Schrödinger operators Ho on and on that dynamical localization holds, i.e. that, with probability one, for a suitable energy interval I and for q a positive real, Here ψ is a function of sufficiently rapid decrease, and PI(Ho) is the spectral projector of Ho corresponding to the interval I. The result is obtained through the control of the decay of the eigenfunctions of Ho and covers, in the discrete case, the Anderson tight-binding model with Bernoulli potential (dimension ν = 1) or singular potential (ν > 1), and in the continuous case Anderson as well as random Landau Hamiltonians.

Mantle to Surface Dynamics Across Subduction-Collision Transitions in Space and Time: Results from the CD-CAT Project in Anatolia

NASA Astrophysics Data System (ADS)

Whitney, D. L.; Abgarmi, B.; Beck, S. L.; Brocard, G. Y.; Cosca, M. A.; Darin, M. H.; Delph, J. R.; Hui, H.; Kahraman, M.; Kaymakci, N.; Kuscu, G.; Meijers, M. J.; Mulch, A.; Özacar, A.; Portner, D. E.; Reid, M. R.; Rey, P. F.; Rojay, B.; Schlieffarth, W. K.; Sandvol, E. A.; Schoenbohm, L. M.; Tank, B.; Teoman, U.; Teyssier, C. P.; Thomson, S. N.; Turkelli, N.; Umhoefer, P. J.; Uslular, G.; Willenbring, J. K.

2017-12-01

From west to east, the southern plate boundary of Anatolia varies from subduction to continental collision; plate dynamics are influenced by the interaction of back-arc extension in the west (Aegean) and convergence in the east (Arabia-Eurasia). Prior to 40 Ma, the entire margin was a subduction zone. The NSF project "Continental Dynamics-Central Anatolian Tectonics (CD-CAT)" has contributed to understanding how the mantle, crust, and surface evolve in subduction-to-collision transitions in time and space. Differences are seen in changes in deformation style as collision proceeded; e.g. from distributed across a broad zone to highly localized on a series of oblique-slip faults, and from transpression to transtension (W of the Central Anatolian fault zone, CAFZ) or strike-slip (E of the CAFZ); age, composition, and sources of magmatism, including a magmatic lull from 40-20 Ma, followed by expansion of magmatism SE-ward in central Anatolia; properties and architecture of the lithosphere and sub-lithospheric mantle (e.g. significant and locally abrupt crustal thickness variations, including thick crust under the Tauride Mts; thin to absent lithospheric mantle; and a torn and disaggregating slab that varies from shallow to steep below central Anatolia); and a topographic gradient from a high eastern plateau (> 2 km) to a central plateau (1-1.5 km) bounded to the N and S by mountain ranges that rose > 2 km from the sea between 11-5 Ma, producing a rain shadow in the Anatolian interior. Thermochronologic and structural studies of exhumed mid-crust and associated basins and fault zones as well as geophysical data for Anatolia today show the extent to which inherited features (suture zones, faults) have affected the tectonic evolution of Anatolia, particularly in the vicinity of the CAFZ/East Anatolian Fault, and mantle properties. Results also show that the Miocene was a dynamic time in the thermal and mechanical evolution of the region, as early Miocene rollback/foundering of the subducted slab drove major volcanism, faulting, and landscape changes (uplift). Slab dynamics below Anatolia accelerated the late Miocene-Pliocene transition from distributed to highly localized deformation, including inception of the North and East Anatolia strike-slip faults that today accommodate tectonic escape of Anatolia.

KSC-2009-1956

NASA Image and Video Library

2009-03-06

CAPE CANAVERAL, Fla. – The Delta II 7925 rocket stands ready for launch following rollback of the mobile service tower on Launch Pad 17-B at Cape Canaveral Air Force Station. Atop the rocket is NASA's Kepler spacecraft. Kepler is a spaceborne telescope designed to search the nearby region of our galaxy for Earth-size planets orbiting in the habitable zone of stars like our sun. The habitable zone is the region around a star where temperatures permit water to be liquid on a planet's surface. The challenge for Kepler is to look at a large number of stars in order to statistically estimate the total number of Earth-size planets orbiting sun-like stars in the habitable zone. Kepler will survey more than 100,000 stars in our galaxy. Photo credit: NASA/Jack Pfaller

KSC-2009-1961

NASA Image and Video Library

2009-03-06

CAPE CANAVERAL, Fla. – After rollback of the mobile service tower on Cape Canaveral Air Force Station's Launch Pad 17-B, in Florida, NASA's Kepler spacecraft sits poised for launch atop the United Launch Alliance Delta II 7925 rocket. Kepler is a spaceborne telescope designed to search the nearby region of our galaxy for Earth-size planets orbiting in the habitable zone of stars like our sun. The habitable zone is the region around a star where temperatures permit water to be liquid on a planet's surface. The challenge for Kepler is to look at a large number of stars in order to statistically estimate the total number of Earth-size planets orbiting sun-like stars in the habitable zone. Kepler will survey more than 100,000 stars in our galaxy. Photo credit: NASA/Jack Pfaller

KSC-2009-1963

NASA Image and Video Library

2009-03-06

CAPE CANAVERAL, Fla. – After rollback of the mobile service tower on Cape Canaveral Air Force Station's Launch Pad 17-B in Florida, NASA's Kepler spacecraft sits poised for launch atop the United Launch Alliance Delta II 7925 rocket. Kepler is a spaceborne telescope designed to search the nearby region of our galaxy for Earth-size planets orbiting in the habitable zone of stars like our sun. The habitable zone is the region around a star where temperatures permit water to be liquid on a planet's surface. The challenge for Kepler is to look at a large number of stars in order to statistically estimate the total number of Earth-size planets orbiting sun-like stars in the habitable zone. Kepler will survey more than 100,000 stars in our galaxy. Photo credit: NASA/Jack Pfaller

Reversible Parallel Discrete-Event Execution of Large-scale Epidemic Outbreak Models

DOE Office of Scientific and Technical Information (OSTI.GOV)

Perumalla, Kalyan S; Seal, Sudip K

2010-01-01

The spatial scale, runtime speed and behavioral detail of epidemic outbreak simulations together require the use of large-scale parallel processing. In this paper, an optimistic parallel discrete event execution of a reaction-diffusion simulation model of epidemic outbreaks is presented, with an implementation over themore » $$\\mu$$sik simulator. Rollback support is achieved with the development of a novel reversible model that combines reverse computation with a small amount of incremental state saving. Parallel speedup and other runtime performance metrics of the simulation are tested on a small (8,192-core) Blue Gene / P system, while scalability is demonstrated on 65,536 cores of a large Cray XT5 system. Scenarios representing large population sizes (up to several hundred million individuals in the largest case) are exercised.« less

KSC-08pd3269

NASA Image and Video Library

2008-10-20

CAPE CANAVERAL, Fla. - Space shuttle Atlantis rolls through the open gate of Launch Pad 39A at NASA's Kennedy Space Center in Florida. First motion was at 6:48 a.m. EDT. Atlantis is rolling back to the Vehicle Assembly Building to await launch on its STS-125 mission to repair NASA's Hubble Space Telescope. Atlantis' targeted launch on Oct. 14 was delayed when a system that transfers science data from the orbiting observatory to Earth malfunctioned on Sept. 27. The new target launch date is under review. The space shuttle is mounted on a Mobile Launcher Platform and will be delivered to the Vehicle Assembly Building atop a crawler transporter. traveling slower than 1 mph during the 3.4-mile journey. The rollback is expected to take approximately six hours. Photo credit: NASA/Kim Shiflett

Design of a fault tolerant airborne digital computer. Volume 2: Computational requirements and technology

NASA Technical Reports Server (NTRS)

Ratner, R. S.; Shapiro, E. B.; Zeidler, H. M.; Wahlstrom, S. E.; Clark, C. B.; Goldberg, J.

1973-01-01

This final report summarizes the work on the design of a fault tolerant digital computer for aircraft. Volume 2 is composed of two parts. Part 1 is concerned with the computational requirements associated with an advanced commercial aircraft. Part 2 reviews the technology that will be available for the implementation of the computer in the 1975-1985 period. With regard to the computation task 26 computations have been categorized according to computational load, memory requirements, criticality, permitted down-time, and the need to save data in order to effect a roll-back. The technology part stresses the impact of large scale integration (LSI) on the realization of logic and memory. Also considered was module interconnection possibilities so as to minimize fault propagation.

KSC-2009-1962

NASA Image and Video Library

2009-03-06

CAPE CANAVERAL, Fla. – After rollback of the mobile service tower on Cape Canaveral Air Force Station's Launch Pad 17-B in Florida, NASA's Kepler spacecraft sits poised for launch atop the United Launch Alliance Delta II 7925 rocket. Kepler is a spaceborne telescope designed to search the nearby region of our galaxy for Earth-size planets orbiting in the habitable zone of stars like our sun. The habitable zone is the region around a star where temperatures permit water to be liquid on a planet's surface. The challenge for Kepler is to look at a large number of stars in order to statistically estimate the total number of Earth-size planets orbiting sun-like stars in the habitable zone. Kepler will survey more than 100,000 stars in our galaxy. Photo credit: NASA/Jack Pfaller

KSC-2009-1959

NASA Image and Video Library

2009-03-06

CAPE CANAVERAL, Fla. – The Delta II 7925 rocket stands ready for launch following rollback of the mobile service tower on Launch Pad 17-B at Cape Canaveral Air Force Station in Florida. Atop the rocket is NASA's Kepler spacecraft. Kepler is a spaceborne telescope designed to search the nearby region of our galaxy for Earth-size planets orbiting in the habitable zone of stars like our sun. The habitable zone is the region around a star where temperatures permit water to be liquid on a planet's surface. The challenge for Kepler is to look at a large number of stars in order to statistically estimate the total number of Earth-size planets orbiting sun-like stars in the habitable zone. Kepler will survey more than 100,000 stars in our galaxy. Photo credit: NASA/Jack Pfaller

KSC-2009-1958

NASA Image and Video Library

2009-03-06

CAPE CANAVERAL, Fla. – The Delta II 7925 rocket stands ready for launch following rollback of the mobile service tower on Launch Pad 17-B at Cape Canaveral Air Force Station in Florida. Atop the rocket is NASA's Kepler spacecraft. Kepler is a spaceborne telescope designed to search the nearby region of our galaxy for Earth-size planets orbiting in the habitable zone of stars like our sun. The habitable zone is the region around a star where temperatures permit water to be liquid on a planet's surface. The challenge for Kepler is to look at a large number of stars in order to statistically estimate the total number of Earth-size planets orbiting sun-like stars in the habitable zone. Kepler will survey more than 100,000 stars in our galaxy. Photo credit: NASA/Jack Pfaller

KSC-2009-1955

NASA Image and Video Library

2009-03-06

CAPE CANAVERAL, Fla. – The Delta II 7925 rocket stands ready for launch following rollback of the mobile service tower on Launch Pad 17-B at Cape Canaveral Air Force Station. Atop the rocket is NASA's Kepler spacecraft. Kepler is a spaceborne telescope designed to search the nearby region of our galaxy for Earth-size planets orbiting in the habitable zone of stars like our sun. The habitable zone is the region around a star where temperatures permit water to be liquid on a planet's surface. The challenge for Kepler is to look at a large number of stars in order to statistically estimate the total number of Earth-size planets orbiting sun-like stars in the habitable zone. Kepler will survey more than 100,000 stars in our galaxy. Photo credit: NASA/Jack Pfaller

KSC-08pd1620

NASA Image and Video Library

2008-06-11

CAPE CANAVERAL, Fla. -- On Cape Canaveral Air Force Station's Launch Pad 17-B, NASA's Gamma-ray Large Area Space Telescope , or GLAST, sits poised for launch atop the United Launch Alliance Delta II rocket after rollback of the mobile service tower. GLAST is a powerful space observatory that will explore the universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Launch is scheduled for 11:45 a.m. June 11. Photo credit: Carleton Bailie photograph for United Launch Alliance

KSC-08pd1621

NASA Image and Video Library

2008-06-11

CAPE CANAVERAL, Fla. -- On Cape Canaveral Air Force Station's Launch Pad 17-B, NASA's Gamma-ray Large Area Space Telescope , or GLAST, sits poised for launch atop the United Launch Alliance Delta II rocket after rollback of the mobile service tower. GLAST is a powerful space observatory that will explore the universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Launch is scheduled for 11:45 a.m. June 11. Photo credit: Carleton Bailie photograph for United Launch Alliance

KSC-08pd1623

NASA Image and Video Library

2008-06-11

CAPE CANAVERAL, Fla. -- On Cape Canaveral Air Force Station's Launch Pad 17-B, NASA's Gamma-ray Large Area Space Telescope , or GLAST, sits poised for launch atop the United Launch Alliance Delta II rocket after rollback of the mobile service tower. GLAST is a powerful space observatory that will explore the universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Launch is scheduled for 11:45 a.m. June 11. Photo credit: Carleton Bailie photograph for United Launch Alliance

KSC-08pd1622

NASA Image and Video Library

2008-06-11

CAPE CANAVERAL, Fla. -- On Cape Canaveral Air Force Station's Launch Pad 17-B, NASA's Gamma-ray Large Area Space Telescope , or GLAST, sits poised for launch atop the United Launch Alliance Delta II rocket after rollback of the mobile service tower. GLAST is a powerful space observatory that will explore the universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Launch is scheduled for 11:45 a.m. June 11. Photo credit: Carleton Bailie photograph for United Launch Alliance

Delta II SIRTF MST Rollback

NASA Image and Video Library

2003-08-24

The mobile service tower is rolled back at Launch Pad 17-B, Cape Canaveral Air Force Station, to reveal NASA's Space Infrared Telescope Facility (SIRTF) ready for launch aboard a Delta II Heavy launch vehicle. Liftoff is scheduled for Aug. 25 at 1:35:39 a.m. EDT. SIRTF will obtain images and spectra by detecting the infrared energy, or heat, radiated by objects in space. Consisting of a 0.85-meter telescope and three cryogenically cooled science instruments, SIRTF will be the largest infrared telescope ever launched into space. It is the fourth and final element in NASA’s family of orbiting “Great Observatories.” Its highly sensitive instruments will give a unique view of the Universe and peer into regions of space that are hidden from optical telescopes.

A Scheduling Algorithm for Replicated Real-Time Tasks

NASA Technical Reports Server (NTRS)

Yu, Albert C.; Lin, Kwei-Jay

1991-01-01

We present an algorithm for scheduling real-time periodic tasks on a multiprocessor system under fault-tolerant requirement. Our approach incorporates both the redundancy and masking technique and the imprecise computation model. Since the tasks in hard real-time systems have stringent timing constraints, the redundancy and masking technique are more appropriate than the rollback techniques which usually require extra time for error recovery. The imprecise computation model provides flexible functionality by trading off the quality of the result produced by a task with the amount of processing time required to produce it. It therefore permits the performance of a real-time system to degrade gracefully. We evaluate the algorithm by stochastic analysis and Monte Carlo simulations. The results show that the algorithm is resilient under hardware failures.

Plate-Tectonic Circulation is Driven by Cooling From the Top and is Closed Within the Upper Mantle

NASA Astrophysics Data System (ADS)

Hamilton, W. B.

2001-12-01

Subduction drives plate tectonics and is due to cooling from the top: circulation is self-organized, and likely is closed above the discontinuity near 660 km. The contrary consensus that plate tectonics is driven by bottom heating and involves the entire mantle combines misunderstood kinematics with flawed concepts of through-the-mantle plumes and subduction. Plume conjecture came from the Emperor-Hawaii progression, the 45 Ma inflection in which was assumed to mark a 60-degree change in direction of that part of the Pacific plate over a fixed plume. Smooth spreading patterns around the east and south margin of the Pacific plate, and paleomagnetic data, disprove such a change. Speculations that plumes move, jump, etc. do not revive falsified conjecture. Geochemical distinctions between enriched island and depleted ridge basalts (which overlap) are expected products of normal upper-mantle processes, not plumes. MORB traverses solidus-T asthenosphere, whereas OIB zone-refines through subsolidus lithosphere and crust, crystallizing refractories to retain T of diminishing melt while assimilating and retaining fusibles. Tomographic inference of deep-mantle subduction is presented misleadingly and may reflect methodological and sampling artifacts (downward smearing, and concentration of recorded body waves in bundles within broad anomalies otherwise poorly sampled). Planetological and other data require hot Earth accretion, and thorough early fractionation, from material much more refractory than primitive meteorites, and are incompatible with the little-fractionated lower mantle postulated to permit whole-mantle circulation. The profound seismic discontinuity near 660 km is a thermodynamic and physical barrier to easy mass transfer in either direction. Refractory lower mantle convects slowly, perhaps in layers, and loses primarily original heat, whereas upper mantle churns rapidly, and the 660 decoupling boundary must have evolved into a compositional barrier also. Plate motions are driven by subduction, the passive falling away of oceanic lithosphere which is negatively buoyant because of top-down cooling. Slabs have top and bottom rolling hinges and sink subvertically (inclinations of slabs mark their positions, not trajectories) into the transition zone, where they are laid down on, and depress, the 660-km discontinuity. Rollback of upper hinges into subducting plates is required by plate behavior at all scales. That fronts of overriding plates advance at rollback velocity is required by common preservation atop their thin leading edges of little-deformed fore-arc basins. Convergence velocity also commonly equals rollback but is faster in some arcs. Steeply-sinking inclined slabs push sublithospheric upper mantle forward into the shrinking ocean from which they came, forcing seafloor spreading therein, and pull overriding plates behind them. Continental plates pass over sunken slabs like tanks above their basal treads, and material from, and displaced rearward by, sunken slabs is cycled into pull-apart oceans opening behind the continents, thus transferring mantle from shrinking to enlarging oceans. Hot mantle displaced above slabs enables backarc spreading. Spreading ridges, in both shrinking and enlarging oceans, are passive byproducts of subduction, and migrate because it is more energy efficient to process new asthenosphere than to get partial melt from increasingly distant sources. A plate-motion framework wherein hinges roll back, ridges migrate, Antarctica is approximately fixed, and intraplate deformation is integrated may approximate an absolute reference to sluggish lower mantle, whereas the hotspot frame is invalid, and the no-net-rotation frame minimizes trench and ridge motions.

Geochemical Consequences of Lithospheric Delamination in the Eastern Mediterranean: Evidence From Young Turkish Basalts

NASA Astrophysics Data System (ADS)

Furman, T.; Kurkcuoglu, B.; Plummer, C.

2007-12-01

Magmatism associated with continental collision is increasingly attributed to major disturbance of or within the lithosphere. Geochemical and isotopic data on post-collisional primitive mafic lavas from across the Anatolian plate enable us to assess the effects of lithospheric delamination (slab rollback and breakoff) as indicated by geophysical studies. The Anatolian province displays geodynamically complex manifestations of the closure of neo-Tethys and the collision between Africa and Europe that commenced circa 30 Ma. The current south- southwestward motion of Anatolia, a.k.a. "Turkish escape", is accommodated by slab rollback along the Hellenic trench and orogenic collapse along both the eastern and western margins of the microplate. Volcanism occurs primarily along the fault zones that border and cross-cut Anatolia, and major element characteristics of the lavas vary with both space and time. In Western Anatolia, early Miocene collisional calc- alkaline magmatism was followed by Quaternary alkaline volcanism (Alici et al. 1998, 2002; Aldanmaz et al. 2000, 2006) related to orogenic collapse, presumably resulting from slab rollback. Orogenic collapse in Eastern Anatolia is facilitated by slab breakoff as determined by geophysical studies (Zor et al. 2003; Angus et al. 2006; Lei & Zhao 2007). This transition was accompanied a change from mid-Miocene calc-alkaline to Quaternary alkaline volcanism (e.g., Yilmaz 1990; Pearce et al. 1990). Central Anatolia displays calc-alkaline and tholeiitic volcanism, including alkali olivine basalts; plate tectonic reconstructions (Lyberis et al. 1992) indicate that the African slab did not reach Central Anatolia. Sr-Nd isotope values from each volcanic province define linear arrays that converge upon a common unradiogenic value typical of global depleted mantle. We suggest that mafic volcanism throughout Anatolia is supported by a common asthenospheric component, modified by identifiable, location-specific additions. In areas of lithospheric removal, young basalts have Sr-Nd values close to that of the inferred asthenospheric source, whereas older lavas display more enriched signatures. Limited Pb isotopic data fall within the range of Atlantic and Pacific Ocean sediments, suggesting the mantle signature is masked or strongly influenced by sediments. We focus on the Sivas volcanics, northernmost of the Central provinces, where the most highly magnesian lavas of Anatolia are found. Incompatible trace element considerations suggest that the Sivas suite provides key insights into the nature of the common source region. These lavas have MORB- and OIB-like values of most incompatible trace elements e.g., La/Nb, Ba/Nb, Ba/Rb, Rb/Sr and Th/La, and lack positive Pb anomalies characteristic of crustal interaction. Their geochemical and isotopic compositions - and comparisons between Sivas and areas of orogenic collapse to the east and west - provide new information on the interaction between lithospheric and asthenospheric materials across Turkey. References: Aldanmaz et al. 2000 JVGR 102, 67-95; Aldanmaz et al. 2006 Lithos 86, 50-76; Alici et al. 1998 JVGR 85, 423-446; Alici et al. 2002 JVGR 115, 487-510; Angus et al. 2006 GJI 166, 1335-1346; Lei & Zhao 2007 EPSL 257, 14-28; Lyberis et al. 1992 Tectonophysics 204, 1-15; Pearce et al. 1990 JVGR 44, 189-229; Yilmaz 1990 JVGR 44, 69-87; Zor et al. 2003 GRL 30, doi: 10.1029/2003GL018192

Active and Inactive Leg Hemodynamics during Sequential Single-Leg Interval Cycling.

PubMed

Gordon, Nicole; Abbiss, Chris R; Ihsan, Mohammed; Maiorana, Andrew J; Peiffer, Jeremiah J

2018-06-01

Leg order during sequential single-leg cycling (i.e., exercising both legs independently within a single session) may affect local muscular responses potentially influencing adaptations. This study examined the cardiovascular and skeletal muscle hemodynamic responses during double-leg and sequential single-leg cycling. Ten young healthy adults (28 ± 6 yr) completed six 1-min double-leg intervals interspersed with 1 min of passive recovery and, on a separate occasion, 12 (six with one leg followed by six with the other leg) 1-min single-leg intervals interspersed with 1 min of passive recovery. Oxygen consumption, heart rate, blood pressure, muscle oxygenation, muscle blood volume, and power output were measured throughout each session. Oxygen consumption, heart rate, and power output were not different between sets of single-leg intervals, but the average of both sets was lower than the double-leg intervals. Mean arterial pressure was higher during double-leg compared with sequential single-leg intervals (115 ± 9 vs 104 ± 9 mm Hg, P < 0.05) and higher during the initial compared with second set of single-leg intervals (108 ± 10 vs 101 ± 10 mm Hg, P < 0.05). The increase in muscle blood volume from baseline was similar between the active single leg and the double leg (267 ± 150 vs 214 ± 169 μM·cm, P = 0.26). The pattern of change in muscle blood volume from the initial to second set of intervals was significantly different (P < 0.05) when the leg was active in the initial (-52.3% ± 111.6%) compared with second set (65.1% ± 152.9%). These data indicate that the order in which each leg performs sequential single-leg cycling influences the local hemodynamic responses, with the inactive muscle influencing the stimulus experienced by the contralateral leg.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dinshaw, Ketayun A.; Budrukkar, Ashwini N.; Chinoy, Roshan F.

Purpose: The outcome of breast cancer treatment can vary in different geographic and ethnic groups. A multivariate analysis was performed for various prognostic factors in 1022 Indian women with pathologic Stage I-II breast cancer treated between 1980 and 2000 with standard breast-conserving therapy with or without systemic adjuvant therapy. Methods and Materials: At a mean follow-up of 53 months, the outcomes studied were local failure, locoregional failure, and distant failure, overall survival (OS), and disease-free survival (DFS). Results: The median pathologic tumor size was 3 cm (range, 1-5 cm), and axillary lymph node metastasis was present in 39% of women.more » The actuarial 5- and 10-year OS and DFS rate was 87% and 77% and 76% and 68%, respectively. Lymphovascular emboli or invasion (LVI) was the strongest independent adverse factor for all failure and survival (local failure, hazard ratio 2.85; 95% confidence interval, 1.68-4.83; OS; hazard ratio, 2.01, 95% confidence interval, 1.35-2.99). Lymph node metastasis was also an independent adverse factor for local failure, locoregional failure, distant failure, DFS, and OS (hazard ratio, 1.55, 95% confidence interval, 1.04-2.30). Age {<=}40 years increased the incidence of local recurrence, and patients with inner quadrant tumors had inferior DFS. The incidence of LVI was significantly greater in women with lymph node metastases than in node-negative women (p < 0.001) and in women with Grade 3 tumors than in those with Grade 1 or 2 tumors (p = 0.001). Conclusion: In Indian women, LVI was the strongest independent prognostic factor for OS, DFS, and local recurrence, irrespective of nodal status and systemic adjuvant treatment. Although LVI may not be a contraindication for BCT, as has been proposed by certain groups, it is necessary to define its role in prospective studies in determining local and systemic treatment.« less

Detrital Geochemical Fingerprints of Rivers Along Southern Tibet and Nepal: Implications for Erosion of the Indus-Yarlung Suture Zone and the Himalayas

NASA Astrophysics Data System (ADS)

Hassim, M. F. B.; Carrapa, B.; DeCelles, P. G.; Kapp, P. A.; Gehrels, G. E.

2014-12-01

Our detrital geochemical study of modern sand collected from tributaries of the Yarlung River in southern Tibet and the Kali Gandaki River and its tributaries in Nepal shed light on the ages and exhumation histories of source rocks within the Indus-Yarlung Suture (IYS) zone and the Himalayas. Seven sand samples from rivers along the suture zone in southern Tibet between Xigatze to the east and Mt. Kailas to the west were collected for detrital zircon U-Pb geochronologic and Apatite Fission Track (AFT) thermochronologic analyses. Zircon U-Pb ages for all rivers range between 15 and 3568 Ma. Rivers draining the northern side of the suture zone mainly yield ages between 40 and 60 Ma, similar to the age of the Gangdese magmatic arc. Samples from rivers draining the southern side of the suture zone record a Tethyan Himalayan signal characterized by age clusters at 500 Ma and 1050 Ma. Our results indicate that the ages and proportion of U-Pb zircons ages of downstream samples from tributaries of the Yarlung River directly reflect source area ages and relative area of source rock exposure in the catchment basin. Significant age components at 37 - 40 Ma, 47 - 50 Ma, 55 - 58 Ma and 94 - 97 Ma reflect episodicity in Gangdese arc magmatism. Our AFT ages show two main signals at 23-18 Ma and 12 Ma, which are in agreement with accelerated exhumation of the Gangdese batholith during these time intervals. The 23 - 18 Ma signal partly overlaps with deposition of the Kailas Formation along the suture zone and may be related to exhumation due to upper plate extension in southern Tibet in response to Indian slab rollback and/or break-off events. Detrital thermochronology of four sand samples from the Kali Gandaki River and some of its tributaries in Nepal is underway and will provide constraints on the timing of erosion of the central Nepal Himalaya.

Transverse ion energization and low-frequency plasma waves in the mid-altitude auroral zone - A case study

NASA Technical Reports Server (NTRS)

Peterson, W. K.; Shelley, E. G.; Boardsen, S. A.; Gurnett, D. A.; Ledley, B. G.; Sugiura, M.; Moore, T. E.

1988-01-01

Evidence of transverse ion energization at altitudes of several earth radii in the auroral zone was reexamined using several hundred hours of high-sensitivity and high-resolution plasma data obtained by the Dynamics Explorer 1 satellite. The data on particle environment encountered at midaltitudes in the auroral zone disclosed rapid variations in the values of total density, thermal structure, and composition of the plasma in the interval measured; the modes of low-frequency plasma waves also varied rapidly. It was not possible to unambiguously identify in these data particle and wave signature of local transverse ion energization; however, many intervals were found where local transverse ion heating was consistent with the observations.

Tectonic and Magmatic Controls on Extension and Crustalaccretion in Backarc Basins, Insights from the Lau Basin and Southern Mariana Trough

NASA Astrophysics Data System (ADS)

Sleeper, Jonathan D.

This dissertation examines magmatic and tectonic processes in backarc basins, and how they are modulated by plate- and mantle-driven mechanisms. Backarc basins initiate by tectonic rifting near the arc volcanic front and transition to magmatic seafloor spreading. As at mid-ocean ridges (MORs), spreading can be focused in narrow plate boundary zones, but we also describe a diffuse spreading mode particular to backarc basins. At typical MORs away from hot spots and other melting anomalies, spreading rate is the primary control on the rate of mantle upwelling and decompression melting. At backarc spreading centers, water derived from the subducting slab creates an additional mantle-driven source of melt and buoyant upwelling. Furthermore, because basins open primarily in response to trench rollback, which is inherently a non-rigid process, backarc extensional systems often have to respond to a constantly evolving stress regime, generating complex tectonics and unusual plate boundaries not typically found at MORs. The interplay between these plate- and mantle-driven processes gives rise to the variety of tectonic and volcanic morphologies peculiar to backarc basins. Chapter 2 is focused on the Fonualei Rift and Spreading Center in the Lau Basin. The southern portion of the axis is spreading at ultraslow (<20 mm/yr) opening rates in close proximity to the arc volcanic front and axial morphology abruptly changes from a volcanic ridge to spaced volcanic cones resembling arc volcanoes. Spreading rate and arc proximity appear to control transitions between two-dimensional and three-dimensional mantle upwelling and volcanism. In the second study (Chapter 3), I develop a new model for the rollback-driven kinematic and tectonic evolution of the Lau Basin, where microplate tectonics creates rapidly changing plate boundary configurations. The third study (Chapter 4) focuses on the southern Mariana Trough and the transitions between arc rifting, seafloor spreading, and a new mode of "diffuse spreading," where new crust is accreted in broad zones rather than along a narrow spreading axis, apparently controlled by a balance between slab water addition and its extraction due to melting and crustal accretion.

Thermal Evolution of Diapirs with Complex Mantle Wedge Flow

NASA Astrophysics Data System (ADS)

Sylvia, R. T.; Kincaid, C.

2016-12-01

Subduction of oceanic lithosphere drives heat and mass exchange between Earth's interior and surface. One proposed transport mechanism for thermally and chemically distinct material through the wedge is the diapir model. The dominant driver of flow in the upper mantle is a mode of forced convection responding to motion of a tabular slab. A set of 4D laboratory experiments was conducted exploring the relationship between buoyancy flux and subduction parameters and subsequent effects on diapir transport. Variable subduction styles tested include downdip and rollback motion, slab gaps, slab steepening and backarc extension. The mantle is modeled using viscous glucose syrup with an Arrhenius type temperature dependent viscosity. Diapirs representing homogeneous mechanically mixed melange layer are introduced as buoyant fluid injected at multiple point sources situated along the surface of the sinking slab. Laboratory data is collected using high definition time-lapse photography and quantified using image velocimetry techniques. Here we present results from numerical simulation of the thermal evolution of spherical mantle wedge diapirs using 2D axisymmetric advection-diffusion model with internal diapir flow described by an analytic potential flow solution. A suite of wedge temperature profiles are used as thermal forcing on diapirs traversing the wedge along experimentally observed 4D ascent pathways. Scaling arguments suggest that for systems with Péclet number on the order of 15 advective heat transport is expected to dominate over diffusive heat transport, but the range of observed P-T-t paths and vigorous internal flow complicate this assumption. Interactions between modes of free (diapiric) and forced (wedge) convection lead to complex spatio-temporal variability in slab-to-arc connectivity patterns. Rollback induced toroidal flow, along trench changes in dip, convergence rate and backarc extension all produce a significant ( 500 km) trench-parallel transport component. Combined with diapir-diapir interactions these factors produce a spectrum of transit times and pathlengths, ranging from much shorter to much longer than those from simple 2D model estimates. Results highlight the broad range of expected internal temperature distributions derived from variable transit paths.

Late Alpine to recent thick-skinned tectonics of the central Swiss Molasse Basin, Canton of Bern, Switzerland

NASA Astrophysics Data System (ADS)

Mock, Samuel; Allenbach, Robin; Wehrens, Philip; Reynolds, Lance; Kurmann-Matzenauer, Eva; Michael, Salomè; Herwegh, Marco

2017-04-01

The Swiss Molasse Basin (SMB) forms part of the North Alpine Foreland Basin. It is a typical peripheral foreland basin, which developed in Paleogene and Neogene times in response to flexural bending of the European lithosphere induced by the orogenic loading of the advancing Alpine thrust wedge. The tectonics of the SMB and the role of Paleozoic and Mesozoic structures are still poorly understood. It is widely accepted that during the main deformation phase of the Jura fold-and-thrust belt, the SMB was riding piggy-back above a major detachment horizon situated within Triassic evaporites. In recent years it has been observed that the Jura fold-and-thrust belt is today deforming in a thick-skinned tectonic style. As for the western and central SMB, most authors still argue in favor of a classical foreland type, thin-skinned style of deformation. Based on the geological 3D modeling of seismic interpretations, we present new insights into the structural configuration of the central SMB. Revised and new interpretations of 2D reflection seismic data from the 1960s to the 1980s reveal a major strike-slip fault zone affecting not only the Mesozoic and Cenozoic cover, but also the crystalline basement beneath. The fault zone reactivated late Paleozoic synsedimentary normal faults bounding a Permo-Carboniferous trough. Basement-involved thrusting observed in the southern part of the SMB seems to be controlled by the presence of slightly inverted Permo-Carboniferous troughs as well. These observations, combined with a compiled structural map and the distribution of recent earthquake hypocenters suggest a late stage, NNW-SSE directed, compressional thick-skinned and strike-slip dominated tectonic activity of the central SMB, post-dating the main deformation phase of the Jura fold-and-thrust belt. This still ongoing deformation might be related to the slab rollback of the European plate and the associated lower crustal delamination as recently suggested by Singer et al. (2014). References: Singer, J., Diehl, T., Husen, S., Kissling, E., Duretz, T., 2014. Alpine lithosphere slab rollback causing lower crustal seismicity in northern foreland. Earth Planet. Sci. Lett. 397, 42-56. doi:10.1016/j.epsl.2014.04.002

Lithospheric structure of an incipient rift basin: Results from receiver function analysis of Bransfield Strait, NW Antarctic Peninsula

NASA Astrophysics Data System (ADS)

Biryol, C. Berk; Lee, Stephen J.; Lees, Jonathan M.; Shore, Michael J.

2018-06-01

Bransfield Basin (BB), located northwest of the Antarctic Peninsula (AP) and southeast of the South Shetland Islands (SSI), is the most active section of the Antarctic continental margin. The region has long been (50 Ma) a convergent plate boundary where the Phoenix plate was subducting beneath the Antarctic Plate and is characterized by long-lived arc magmatism and accretion. However, the collision of the Antarctic-Phoenix spreading center with the subduction front near SSI (ca. 4 Ma) gave way to the opening of slab windows and dramatic decrease in the subduction rate of the Phoenix plate beneath AP and SSI. Consequently, the Phoenix slab began to rollback slowly along the South Shetland Trench (SST), giving way to slow extension in the back-arc region and rifting along the BB. Although there is consensus on the factors that control the current deformation and extension of the BB, the origin of the BB and the tectonic configuration of the basin are still unclear. Most of the controversy stems from uncertainties regarding the crustal thickness of the BB. Hence, we computed teleseismic receiver functions for 10 broadband stations in the region that belong to existing permanent and temporary deployments in order obtain robust constraints on the lithospheric structure and crustal thickness of the BB, as well as the AP and SSI. Our results indicate that the crust is thinning from 30 km to 26 km from the AP towards the South Shetland trench and Central BB showing the asymmetrical character of the rift basin. The crustal thickness and Vp/Vs variations are less pronounced along the AP but very significant across the SSB indicating the lithospheric scale segmentation of the South Shetland Block (SSB) and the incipient rift basin under the control of the opening of slab window and the roll-back of stalled Phoenix slab. High Vp/Vs ratios (∼1.9) beneath BB and SSI, agree well with the nascent rift character of BB, the presence of a steep Phoenix slab and consequently a wider mantle wedge characterized by the presence of underplating partial melts beneath SSI and BB.

Temporal and Spatial Fluctuations in Ancestral Northern Cascade Arc Magmatism from New LA-ICP-MS U-Pb Zircon Dating

NASA Astrophysics Data System (ADS)

McCallum, I. S.; Mullen, E.; Jean-Louis, P.; Tepper, J. H.

2015-12-01

Mt. Baker and the adjacent Chilliwack batholith (MBC focus) in NW Washington preserve the longest magmatic record in the Cascade Arc, providing an excellent natural laboratory for examining the spatial, temporal and geochemical evolution of Cascade magmatism and links to tectonic processes. We present new U-Pb zircon LA-ICP-MS ages for 14 samples from MBC and neighboring regions of the north Cascades. The new results are up to 8 Myr different from previous K-Ar ages, illustrating the need for new age determinations in the Cascades. A maximum age of 34.74±0.24 Ma (2σ) (Post Creek stock) is consistent with 35-40 Ma ages for arc inception in the southern Cascades. The most voluminous MBC plutons cluster at 32-29 Ma, consistent with an early flare-up that also coincides with intrusion of the Index batholith farther south (2 samples at 33.26±0.19, 33.53±0.15 Ma). This flare-up is absent in the northernmost Cascades where the oldest pluton (Fall Creek stock) is 6.646±0.046 Ma, 4 Myr younger than previously cited. Earliest Cascade magmatism is progressively younger to the north of MBC, possibly tracing the northerly passage of the slab edge. MBC activity was continuous to 22.75±0.17 Ma (Whatcom Arm), marking the initiation of an 11 Myr hiatus. Magmatism resumed at 11.33±0.08 Ma (Indian Creek) and continued to the modern Mt. Baker cone, defining a pattern of southwesterly migration over ~55 km that may be attributable to slab rollback and arc rotation (e.g. Wells & McCaffrey 2013). Uniformity of the rate and direction of migration implies that rollback and rotation began at least 11 Myr ago. Post-hiatus magmas show distinct geochemical and petrologic characteristics including a major Pb isotopic shift. The 2.430±0.016 Ma Lake Ann stock contains 4.2 Ma zircon antecrysts, recording prolonged activity in that area. The 1.165±0.013 Ma Kulshan caldera ignimbrite contains ~200 Ma inherited zircons that may provide the first direct record of Wrangellian basement beneath the arc.

A direct sensitivity approach to predict hourly ozone resulting from compliance with the National Ambient Air Quality Standard.

PubMed

Simon, Heather; Baker, Kirk R; Akhtar, Farhan; Napelenok, Sergey L; Possiel, Norm; Wells, Benjamin; Timin, Brian

2013-03-05

In setting primary ambient air quality standards, the EPA's responsibility under the law is to establish standards that protect public health. As part of the current review of the ozone National Ambient Air Quality Standard (NAAQS), the US EPA evaluated the health exposure and risks associated with ambient ozone pollution using a statistical approach to adjust recent air quality to simulate just meeting the current standard level, without specifying emission control strategies. One drawback of this purely statistical concentration rollback approach is that it does not take into account spatial and temporal heterogeneity of ozone response to emissions changes. The application of the higher-order decoupled direct method (HDDM) in the community multiscale air quality (CMAQ) model is discussed here to provide an example of a methodology that could incorporate this variability into the risk assessment analyses. Because this approach includes a full representation of the chemical production and physical transport of ozone in the atmosphere, it does not require assumed background concentrations, which have been applied to constrain estimates from past statistical techniques. The CMAQ-HDDM adjustment approach is extended to measured ozone concentrations by determining typical sensitivities at each monitor location and hour of the day based on a linear relationship between first-order sensitivities and hourly ozone values. This approach is demonstrated by modeling ozone responses for monitor locations in Detroit and Charlotte to domain-wide reductions in anthropogenic NOx and VOCs emissions. As seen in previous studies, ozone response calculated using HDDM compared well to brute-force emissions changes up to approximately a 50% reduction in emissions. A new stepwise approach is developed here to apply this method to emissions reductions beyond 50% allowing for the simulation of more stringent reductions in ozone concentrations. Compared to previous rollback methods, this application of modeled sensitivities to ambient ozone concentrations provides a more realistic spatial response of ozone concentrations at monitors inside and outside the urban core and at hours of both high and low ozone concentrations.

The Application of Synoptic Weather Forecasting Rules to Selected Weather Situations in the United States.

ERIC Educational Resources Information Center

Kohler, Fred E.

The document describes the use of weather maps and data in teaching introductory college courses in synoptic meteorology. Students examine weather changes at three-hour intervals from data obtained from the "Monthly Summary of Local Climatological Data." Weather variables in the local summary include sky cover, air temperature, dew point, relative…

Algorithms and Complexity Results for Genome Mapping Problems.

PubMed

Rajaraman, Ashok; Zanetti, Joao Paulo Pereira; Manuch, Jan; Chauve, Cedric

2017-01-01

Genome mapping algorithms aim at computing an ordering of a set of genomic markers based on local ordering information such as adjacencies and intervals of markers. In most genome mapping models, markers are assumed to occur uniquely in the resulting map. We introduce algorithmic questions that consider repeats, i.e., markers that can have several occurrences in the resulting map. We show that, provided with an upper bound on the copy number of repeated markers and with intervals that span full repeat copies, called repeat spanning intervals, the problem of deciding if a set of adjacencies and repeat spanning intervals admits a genome representation is tractable if the target genome can contain linear and/or circular chromosomal fragments. We also show that extracting a maximum cardinality or weight subset of repeat spanning intervals given a set of adjacencies that admits a genome realization is NP-hard but fixed-parameter tractable in the maximum copy number and the number of adjacent repeats, and tractable if intervals contain a single repeated marker.

Trading Speed and Accuracy by Coding Time: A Coupled-circuit Cortical Model

PubMed Central

Standage, Dominic; You, Hongzhi; Wang, Da-Hui; Dorris, Michael C.

2013-01-01

Our actions take place in space and time, but despite the role of time in decision theory and the growing acknowledgement that the encoding of time is crucial to behaviour, few studies have considered the interactions between neural codes for objects in space and for elapsed time during perceptual decisions. The speed-accuracy trade-off (SAT) provides a window into spatiotemporal interactions. Our hypothesis is that temporal coding determines the rate at which spatial evidence is integrated, controlling the SAT by gain modulation. Here, we propose that local cortical circuits are inherently suited to the relevant spatial and temporal coding. In simulations of an interval estimation task, we use a generic local-circuit model to encode time by ‘climbing’ activity, seen in cortex during tasks with a timing requirement. The model is a network of simulated pyramidal cells and inhibitory interneurons, connected by conductance synapses. A simple learning rule enables the network to quickly produce new interval estimates, which show signature characteristics of estimates by experimental subjects. Analysis of network dynamics formally characterizes this generic, local-circuit timing mechanism. In simulations of a perceptual decision task, we couple two such networks. Network function is determined only by spatial selectivity and NMDA receptor conductance strength; all other parameters are identical. To trade speed and accuracy, the timing network simply learns longer or shorter intervals, driving the rate of downstream decision processing by spatially non-selective input, an established form of gain modulation. Like the timing network's interval estimates, decision times show signature characteristics of those by experimental subjects. Overall, we propose, demonstrate and analyse a generic mechanism for timing, a generic mechanism for modulation of decision processing by temporal codes, and we make predictions for experimental verification. PMID:23592967

Steerable dyadic wavelet transform and interval wavelets for enhancement of digital mammography

NASA Astrophysics Data System (ADS)

Laine, Andrew F.; Koren, Iztok; Yang, Wuhai; Taylor, Fred J.

1995-04-01

This paper describes two approaches for accomplishing interactive feature analysis by overcomplete multiresolution representations. We show quantitatively that transform coefficients, modified by an adaptive non-linear operator, can make more obvious unseen or barely seen features of mammography without requiring additional radiation. Our results are compared with traditional image enhancement techniques by measuring the local contrast of known mammographic features. We design a filter bank representing a steerable dyadic wavelet transform that can be used for multiresolution analysis along arbitrary orientations. Digital mammograms are enhanced by orientation analysis performed by a steerable dyadic wavelet transform. Arbitrary regions of interest (ROI) are enhanced by Deslauriers-Dubuc interpolation representations on an interval. We demonstrate that our methods can provide radiologists with an interactive capability to support localized processing of selected (suspicion) areas (lesions). Features extracted from multiscale representations can provide an adaptive mechanism for accomplishing local contrast enhancement. By improving the visualization of breast pathology can improve changes of early detection while requiring less time to evaluate mammograms for most patients.

Reference Intervals of Common Clinical Chemistry Analytes for Adults in Hong Kong.

PubMed

Lo, Y C; Armbruster, David A

2012-04-01

Defining reference intervals is a major challenge because of the difficulty in recruiting volunteers to participate and testing samples from a significant number of healthy reference individuals. Historical literature citation intervals are often suboptimal because they're be based on obsolete methods and/or only a small number of poorly defined reference samples. Blood donors in Hong Kong gave permission for additional blood to be collected for reference interval testing. The samples were tested for twenty-five routine analytes on the Abbott ARCHITECT clinical chemistry system. Results were analyzed using the Rhoads EP evaluator software program, which is based on the CLSI/IFCC C28-A guideline, and defines the reference interval as the 95% central range. Method specific reference intervals were established for twenty-five common clinical chemistry analytes for a Chinese ethnic population. The intervals were defined for each gender separately and for genders combined. Gender specific or combined gender intervals were adapted as appropriate for each analyte. A large number of healthy, apparently normal blood donors from a local ethnic population were tested to provide current reference intervals for a new clinical chemistry system. Intervals were determined following an accepted international guideline. Laboratories using the same or similar methodologies may adapt these intervals if deemed validated and deemed suitable for their patient population. Laboratories using different methodologies may be able to successfully adapt the intervals for their facilities using the reference interval transference technique based on a method comparison study.

Stress direction history of the western United States and Mexico since 85 Ma

NASA Astrophysics Data System (ADS)

Bird, Peter

2002-06-01

A data set of 369 paleostress direction indicators (sets of dikes, veins, or fault slip vectors) is collected from previous compilations and the geologic literature. Like contemporary data, these stress directions show great variability, even over short distances. Therefore statistical methods are helpful in deciding which apparent variations in space or in time are significant. First, the interpolation technique of Bird and Li [1996] is used to interpolate stress directions to a grid of evenly spaced points in each of seventeen 5-m.y. time steps since 85 Ma. Then, a t test is used to search for stress direction changes between pairs of time windows whose sense can be determined with some minimum confidence. Available data cannot resolve local stress provinces, and only the broadest changes affecting country-sized regions are reasonably certain. During 85-50 Ma, the most compressive horizontal stress azimuth $\\hat \\sigma $1H was fairly constant at ~68° (United States) to 75° (Mexico). During 50-35 Ma, both counterclockwise stress changes (in the Pacific Northwest) and clockwise stress changes (from Nevada to New Mexico) are seen, but only locally and with about 50% confidence. A major stress azimuth change by ~90° occurred at 33 +/- 2 Ma in Mexico and at 30 +/- 2 Ma in the western United States. This was probably an interchange between $\\hat \\sigma $1 and $\\hat \\sigma $3 caused by a decrease in horizontal compression and/or an increase in vertical compression. The most likely cause was the rollback of horizontally subducting Farallon slab from under the southwestern United States and northwest Mexico, which was rapid during 35-25 Ma. After this transition, a clockwise rotation of principal stress axes by 36°-48° occurred more gradually since 22 Ma, affecting the region between latitudes 28°N and 41°N. This occurred as the lengthening Pacific/North America transform boundary gradually added dextral shear on northwest striking planes to the previous stress field of SW-NE extension.

Manifestations of Dynamical Localization in the Disordered XXZ Spin Chain

NASA Astrophysics Data System (ADS)

Elgart, Alexander; Klein, Abel; Stolz, Günter

2018-04-01

We study disordered XXZ spin chains in the Ising phase exhibiting droplet localization, a single cluster localization property we previously proved for random XXZ spin chains. It holds in an energy interval I near the bottom of the spectrum, known as the droplet spectrum. We establish dynamical manifestations of localization in the energy window I, including non-spreading of information, zero-velocity Lieb-Robinson bounds, and general dynamical clustering. Our results do not rely on knowledge of the dynamical characteristics of the model outside the droplet spectrum. A byproduct of our analysis is that for random XXZ spin chains this droplet localization can happen only inside the droplet spectrum.

Local Risk-Minimization for Defaultable Claims with Recovery Process

DOE Office of Scientific and Technical Information (OSTI.GOV)

Biagini, Francesca, E-mail: biagini@mathematik.uni-muenchen.de; Cretarola, Alessandra, E-mail: alessandra.cretarola@dmi.unipg.it

We study the local risk-minimization approach for defaultable claims with random recovery at default time, seen as payment streams on the random interval [0,{tau} Logical-And T], where T denotes the fixed time-horizon. We find the pseudo-locally risk-minimizing strategy in the case when the agent information takes into account the possibility of a default event (local risk-minimization with G-strategies) and we provide an application in the case of a corporate bond. We also discuss the problem of finding a pseudo-locally risk-minimizing strategy if we suppose the agent obtains her information only by observing the non-defaultable assets.

Heterogeneities in the Ecoepidemiology of Trypanosoma cruzi Infection in Rural Communities of the Argentinean Chaco

PubMed Central

Cardinal, M. Victoria; Orozco, M. Marcela; Enriquez, Gustavo F.; Ceballos, Leonardo A.; Gaspe, María Sol; Alvarado-Otegui, Julián A.; Gurevitz, Juan M.; Kitron, Uriel; Gürtler, Ricardo E.

2014-01-01

We conducted a cross-sectional survey of Trypanosoma cruzi infection of Triatoma infestans as well as dogs and cats in 327 households from a well-defined rural area in northeastern Argentina to test whether the household distribution of infection differed between local ethnic groups (Tobas and Creoles) and identify risk factors for host infection. Overall prevalence of infection of bugs (27.2%; 95% confidence interval = 25.3–29.3%), dogs (26.0%; 95% confidence interval = 23.3–30.1%), and cats examined (28.7%; 95% confidence interval = 20.2–39.0%) was similar. A multimodel inference approach showed that infection in dogs was associated strongly with the intensity and duration of local exposure to infected bugs and moderately with household ethnic background. Overall, Toba households were at a substantially greater risk of infection than Creole households. The strong heterogeneities in the distribution of bug, dog, and cat infections at household, village, and ethnic group levels may be used for targeted vector and disease control. PMID:24732461

Responding for sucrose and wheel-running reinforcement: effect of D-amphetamine.

PubMed

Belke, T W; Oldford, A C; Forgie, M Y; Beye, J A

2005-07-01

The present study assessed the effect of D-amphetamine on responding maintained by wheel-running and sucrose reinforcement. Six male albino Wistar rats were placed in running wheels and exposed to a fixed-interval 30-s schedule that produced either a drop of 5% sucrose solution or the opportunity to run for 15 s as reinforcing consequences for lever pressing. Each reinforcer type was signaled by a different stimulus. Doses of 0.25, 0.5, 1.0, 1.5, and 3.0 mg/kg D-amphetamine were administered by i.p. injection 20 min prior to a session. As the dose increased, index of curvature values decreased toward zero and rate-dependency plots revealed increases in lower rates early in the interval and decreases in higher rates toward the end of the interval. Effects were similar in the presence of both stimuli. However, an analysis of post-reinforcement pauses and local response rates broken down by transitions revealed a differential effect. As the dose increased, local response rates following a wheel-running reinforcer were affected more than those following a sucrose reinforcer.

KSC00pp0822

NASA Image and Video Library

2000-06-30

After tower rollback just before dawn on Launch Pad 36A, Cape Canaveral Air Force Station, NASA’s Tracking and Data Relay Satellite (TDRS-H) sits bathed in spotlights before liftoff atop an Atlas IIA/Centaur rocket. One of three satellites (labeled H, I and J) being built by the Hughes Space and Communications Company, the latest TDRS uses an innovative springback antenna design. A pair of 15-foot-diameter, flexible mesh antenna reflectors fold up for launch, then spring back into their original cupped circular shape on orbit. The new satellites will augment the TDRS system’s existing Sand Ku-band frequencies by adding Ka-band capability. TDRS will serve as the sole means of continuous, high-data-rate communication with the Space Shuttle, with the International Space Station upon its completion, and with dozens of unmanned scientific satellites in low earth orbit

KSC-00pp0822

NASA Image and Video Library

2000-06-30

After tower rollback just before dawn on Launch Pad 36A, Cape Canaveral Air Force Station, NASA’s Tracking and Data Relay Satellite (TDRS-H) sits bathed in spotlights before liftoff atop an Atlas IIA/Centaur rocket. One of three satellites (labeled H, I and J) being built by the Hughes Space and Communications Company, the latest TDRS uses an innovative springback antenna design. A pair of 15-foot-diameter, flexible mesh antenna reflectors fold up for launch, then spring back into their original cupped circular shape on orbit. The new satellites will augment the TDRS system’s existing Sand Ku-band frequencies by adding Ka-band capability. TDRS will serve as the sole means of continuous, high-data-rate communication with the Space Shuttle, with the International Space Station upon its completion, and with dozens of unmanned scientific satellites in low earth orbit

KSC-2009-1960

NASA Image and Video Library

2009-03-06

CAPE CANAVERAL, Fla. – Against the backdrop of the Atlantic Ocean, the Delta II 7925 rocket stands ready for launch following rollback of the mobile service tower on Launch Pad 17-B at Cape Canaveral Air Force Station. Atop the rocket is NASA's Kepler spacecraft. Kepler is a spaceborne telescope designed to search the nearby region of our galaxy for Earth-size planets orbiting in the habitable zone of stars like our sun. The habitable zone is the region around a star where temperatures permit water to be liquid on a planet's surface. The challenge for Kepler is to look at a large number of stars in order to statistically estimate the total number of Earth-size planets orbiting sun-like stars in the habitable zone. Kepler will survey more than 100,000 stars in our galaxy. Photo credit: NASA/Jack Pfaller

LC-39A RSS Rollback before launch of STS-113

NASA Technical Reports Server (NTRS)

2002-01-01

KENNEDY SPACE CENTER, FLA. -- Space Shuttle Endeavour stands ready for launch on mission STS-113. . The Orbiter Access Arm extends from the Fixed Service Structure (FSS) to the crew compartment hatch, through which the STS-113 crew will enter Endeavour. STS-113 is the 16th American assembly flight to the International Space Station. The primary mission is bringing the Expedition 6 crew to the Station and returning the Expedition 5 crew to Earth. The major objective of the mission is delivery of the Port 1 (P1) Integrated Truss Assembly, which will be attached to the port side of the S0 truss. Three spacewalks are planned to install and activate the truss and its associated equipment. Launch of Space Shuttle Endeavour on mission STS-113 is scheduled for Nov. 11 at 12:58 a.m. EST.

KSC-05PD-1177

NASA Technical Reports Server (NTRS)

2005-01-01

KENNEDY SPACE CENTER, FLA. At NASAs Kennedy Space Center, Space Shuttle Discovery, resting on the Mobile Launcher Platform, rolls into high bay 1 of the Vehicle Assembly Building (VAB). The Shuttle is being rolled back from Launch Pad 39B. It will be demated from its External Tank and lifted into the transfer aisle. On or about June 7, Discovery will be attached to its new tank and Solid Rocket Boosters, which are already in the VAB. Only the 15th rollback in Space Shuttle Program history, the 4.2- mile journey allows additional modifications to be made to the External Tank prior to a safe Return to Flight. Discovery is expected to be rolled back to the launch pad in mid-June for Return to Flight mission STS-114. The launch window extends from July 13 to July 31. [Photo courtesy of Scott Andrews

Space Shuttle Projects

NASA Image and Video Library

2000-11-30

Back dropped by a cloudless blue sky, Space Shuttle Endeavor stands ready for launch after the rollback of the Rotating Service Structure, at left. The orbiter launched that night carrying the STS-97 crew of five. The STS-97 mission's primary objective was the delivery, assembly, and activation of the U.S. electrical power system onboard the International Space Station (ISS). The electrical power system, which is built into a 73-meter (240-foot) long solar array structure, consists of solar arrays, radiators, batteries, and electronics. The entire 15.4-metric ton (17-ton) package is called the P6 Integrated Truss Segment, and is the heaviest and largest element yet delivered to the station aboard a space shuttle. The electric system will eventually provide the power necessary for the first ISS crews to live and work in the U.S. segment.

KSC-2014-3084

NASA Image and Video Library

2014-06-30

VANDENBERG AIR FORCE BASE, Calif. – The United Launch Alliance Delta II rocket carrying NASA's Orbiting Carbon Observatory-2, or OCO-2, is illuminated on Space Launch Complex 2 on Vandenberg Air Force Base in California following rollback of the mobile service tower. Launch is scheduled for 5:56 a.m. EDT on July 1. OCO-2 is NASA’s first mission dedicated to studying atmospheric carbon dioxide, the leading human-produced greenhouse gas driving changes in Earth’s climate. OCO-2 will provide a new tool for understanding the human and natural sources of carbon dioxide emissions and the natural "sinks" that absorb carbon dioxide and help control its buildup. The observatory will measure the global geographic distribution of these sources and sinks and study their changes over time. To learn more about OCO-2, visit http://www.nasa.gov/oco2. Photo credit: NASA/Kim Shiflett

KSC-2014-3071

NASA Image and Video Library

2014-06-30

VANDENBERG AIR FORCE BASE, Calif. – The United Launch Alliance Delta II rocket carrying NASA's Orbiting Carbon Observatory-2, or OCO-2, is illuminated on Space Launch Complex 2 on Vandenberg Air Force Base in California following rollback of the mobile service tower. Launch is scheduled for 5:56 a.m. EDT on July 1. OCO-2 is NASA’s first mission dedicated to studying atmospheric carbon dioxide, the leading human-produced greenhouse gas driving changes in Earth’s climate. OCO-2 will provide a new tool for understanding the human and natural sources of carbon dioxide emissions and the natural "sinks" that absorb carbon dioxide and help control its buildup. The observatory will measure the global geographic distribution of these sources and sinks and study their changes over time. To learn more about OCO-2, visit http://www.nasa.gov/oco2. Photo credit: NASA/Randy Beaudoin

High charge state carbon and oxygen ions in Earth's equatorial quasi-trapping region

NASA Technical Reports Server (NTRS)

Christon, S. P.; Hamilton, D. C.; Gloeckler, G.; Eastmann, T. E.

1994-01-01

Observations of energetic (1.5 - 300 keV/e) medium-to-high charge state (+3 less than or equal to Q less than or equal to +7) solar wind origin C and O ions made in the quasi-trapping region (QTR) of Earth's magnetosphere are compared to ion trajectories calculated in model equatorial magnetospheric magnetic and electric fields. These comparisons indicate that solar wind ions entering the QTR on the nightside as an energetic component of the plasma sheet exit the region on the dayside, experiencing little or no charge exchange on the way. Measurements made by the CHarge Energy Mass (CHEM) ion spectrometer on board the Active Magnetospheric Particle Tracer Explorer/Charge Composition Explorer (AMPTE/CCE) spacecraft at 7 less than L less than 9 from September 1984 to January 1989 are the source of the new results contained herein: quantitative long-term determination of number densities, average energies, energy spectra, local time distributions, and their variation with geomagnetic disturbance level as indexed by Kp. Solar wind primaries (ions with charge states unchanged) and their secondaries (ions with generally lower charge states produced from primaries in the magnetosphere via charge exchange)are observed throughout the QTR and have distinctly different local time variations that persist over the entire 4-year analysis interval. During Kp larger than or equal to 3 deg intervals, primary ion (e.g., O(+6)) densities exhibit a pronounced predawn maximum with average energy minimum and a broad near-local-noon density minimum with average energy maximum. Secondary ion (e.g., O(+5)) densities do not have an identifiable predawn peak, rather they have a broad dayside maximum peaked in local morning and a nightside minimum. During Kp less than or equal to 2(-) intervals, primary ion density peaks are less intense, broader in local time extent, and centered near midnight, while secondary ion density local time variations diminish. The long-time-interval baseline helps to refine and extend previous observations; for example, we show that ionospheric contribution to O(+3)) is negligible. Through comparison with model ion trajectories, we interpret the lack of pronounced secondary ion density peaks colocated with the primary density peaks to indicate that: (1) negligible charge exchange occurs at L greater than 7, that is, solar wind secondaries are produced at L less than 7, and (2) solar wind secondaries do not form a significant portion of the plasma sheet population injected into the QTR. We conclude that little of the energetic solar wind secondary ion population is recirculated through the magnetosphere.

The Ionian and Alfeo-Etna fault zones: New segments of an evolving plate boundary in the central Mediterranean Sea?

NASA Astrophysics Data System (ADS)

Polonia, A.; Torelli, L.; Artoni, A.; Carlini, M.; Faccenna, C.; Ferranti, L.; Gasperini, L.; Govers, R.; Klaeschen, D.; Monaco, C.; Neri, G.; Nijholt, N.; Orecchio, B.; Wortel, R.

2016-04-01

The Calabrian Arc is a narrow subduction-rollback system resulting from Africa/Eurasia plate convergence. While crustal shortening is taken up in the accretionary wedge, transtensive deformation accounts for margin segmentation along transverse lithospheric faults. One of these structures is the NNW-SSE transtensive fault system connecting the Alfeo seamount and the Etna volcano (Alfeo-Etna Fault, AEF). A second, NW-SE crustal discontinuity, the Ionian Fault (IF), separates two lobes of the CA subduction complex (Western and Eastern Lobes) and impinges on the Sicilian coasts south of the Messina Straits. Analysis of multichannel seismic reflection profiles shows that: 1) the IF and the AEF are transfer crustal tectonic features bounding a complex deformation zone, which produces the downthrown of the Western lobe along a set of transtensive fault strands; 2) during Pleistocene times, transtensive faulting reactivated structural boundaries inherited from the Mesozoic Tethyan domain which acted as thrust faults during the Messinian and Pliocene; and 3) the IF and the AEF, and locally the Malta escarpment, accommodate a recent tectonic event coeval and possibly linked to the Mt. Etna formation. Regional geodynamic models show that, whereas AEF and IF are neighboring fault systems, their individual roles are different. Faulting primarily resulting from the ESE retreat of the Ionian slab is expressed in the northwestern part of the IF. The AEF, on the other hand, is part of the overall dextral shear deformation, resulting from differences in Africa-Eurasia motion between the western and eastern sectors of the Tyrrhenian margin of northern Sicily, and accommodating diverging motions in the adjacent compartments, which results in rifting processes within the Western Lobe of the Calabrian Arc accretionary wedge. As such, it is primarily associated with Africa-Eurasia relative motion.

The initiation and tectonic regimes of the Cenozoic extension in the Bohai Bay Basin, North China revealed by numerical modelling

NASA Astrophysics Data System (ADS)

Li, Lu; Qiu, Nansheng

2017-06-01

In this study the dynamic aspects of the Cenozoic extension in the Bohai Bay Basin are considered in the context of initial thickness of the crust and lithosphere, tectonic force, strain rate and thermal rheology, which are directly or indirectly estimated from a pure shear extensional model. It is accordingly reasonable to expect that, in the Bohai Bay Basin, the thickness variation could be present prior to the initiation of extension. The extensional deformation is localized by a thickness variation of the crust and lithosphere and the heterogeneity of the initial thickness plays an important role in rifting dynamics. The onset of rifting requires a critical tectonic force (initial tectonic force) to be applied, which then immediately begins to decay gradually. Rifting will only occur when the total effective buoyancy force of the subducting slab reaches a critical level, after a certain amount of subduction taking place. The magnitude of the tectonic force decreases with time in the early phase of rifting, which indicates the weakening due to the increase in geothermal gradient. In order to deform the continental lithosphere within the currently accepted maximum magnitude of the force derived from subducted slab roll-back, the following conditions should be satisfied: (1) the thickness of the continental lithosphere is significantly thin and less than 125 km and (2) the lithosphere has a wet and hot rheology, which provides implications for rheological layering in continental lithosphere. Our results are strongly supported by the ;crème brûlée; model, in which the lower crust and mantle are relatively ductile.

Tonga Trench gabbros and peridotites: A suit of temporal and spatial forearc materials

NASA Astrophysics Data System (ADS)

Michibayashi, K.; Shinkai, Y.; Tani, K.; Uehara, S.; Harigane, Y.; Ishii, T.; Bloomer, S. H.

2012-12-01

The Tonga trench is one of the deepest oceanic regions in the world (10,866 m). Various types of rocks have been dredged and drilled at several localities on the landward slopes of the trench during Boomerang Leg8 in 1996. In particular, very pristine peridotites outcrop at the most deep landward trench slope. We show that the trench can be divided into two regions: southern region and northern region. The peridotites in the southern region have high-Cr# (0.46-0.83) which were typical of forearc peridotites, whereas the peridotites in the northern region have evidences of the reaction with magma during partial melting. Olivine fabrics are characterized by E-type and D-type. Although E-type and D-type are no clear relationship of mineral composition, grain size and equilibrium temperature, the only difference between E-type and D-type were fabric intensities: D-type has higher fabric intensity than that for E-type. Geochronological study revealed that the gabbros in the southern region have the oldest ages of ~52 Ma that are as old as the oldest rocks in the Izu-Bonin-Mariana arc recording the subduction infancy (e.g., Ishizuka et al., 2011 EPSL). We argue that the southern region preserves the oldest mantle fabrics that took place during the subduction infancy, where pristine and serpentinized peridotites have been deformed in the region where high strain field occurred due to the dragged flow. Eventually, they expose in a very neat condition (i.e. active tectonic erosion and fast ascent rate) resulting from an unique tectonic setting including fast subducting plate (24 cm/yr), fast spreading plate (15 cm/yr) and slab rollback.

A rapid method to map the crustal and lithospheric thickness using elevation, geoid anomaly and thermal analysis. Application to the Gibraltar Arc System, Atlas Mountains and adjacent zones

NASA Astrophysics Data System (ADS)

Fullea, J.; Fernàndez, M.; Zeyen, H.; Vergés, J.

2007-02-01

We present a method based on the combination of elevation and geoid anomaly data together with thermal field to map crustal and lithospheric thickness. The main assumptions are local isostasy and a four-layered model composed of crust, lithospheric mantle, sea water and the asthenosphere. We consider a linear density gradient for the crust and a temperature dependent density for the lithospheric mantle. We perform sensitivity tests to evaluate the effect of the variation of the model parameters and the influence of RMS error of elevation and geoid anomaly databases. The application of this method to the Gibraltar Arc System, Atlas Mountains and adjacent zones reveals the presence of a lithospheric thinning zone, SW-NE oriented. This zone affects the High and Middle Atlas and extends from the Canary Islands to the eastern Alboran Basin and is probably linked with a similarly trending zone of thick lithosphere constituting the western Betics, eastern Rif, Rharb Basin, and Gulf of Cadiz. A number of different, even mutually opposite, geodynamic models have been proposed to explain the origin and evolution of the study area. Our results suggest that a plausible slab-retreating model should incorporate tear and asymmetric roll-back of the subducting slab to fit the present-day observed lithosphere geometry. In this context, the lithospheric thinning would be caused by lateral asthenospheric flow. An alternative mechanism responsible for lithospheric thinning is the presence of a hot magmatic reservoir derived from a deep ancient plume centred in the Canary Island, and extending as far as Central Europe.

Cluster spacecraft observations of a ULF wave enhanced by Space Plasma Exploration by Active Radar (SPEAR)

NASA Astrophysics Data System (ADS)

Badman, S. V.; Wright, D. M.; Clausen, L. B. N.; Fear, R. C.; Robinson, T. R.; Yeoman, T. K.

2009-09-01

Space Plasma Exploration by Active Radar (SPEAR) is a high-latitude ionospheric heating facility capable of exciting ULF waves on local magnetic field lines. We examine an interval from 1 February 2006 when SPEAR was transmitting a 1 Hz modulation signal with a 10 min on-off cycle. Ground magnetometer data indicated that SPEAR modulated currents in the local ionosphere at 1 Hz, and enhanced a natural field line resonance with a 10 min period. During this interval the Cluster spacecraft passed over the heater site. Signatures of the SPEAR-enhanced field line resonance were present in the magnetic field data measured by the magnetometer on-board Cluster-2. These are the first joint ground- and space-based detections of field line tagging by SPEAR.

Timescale- and Sensory Modality-Dependency of the Central Tendency of Time Perception.

PubMed

Murai, Yuki; Yotsumoto, Yuko

2016-01-01

When individuals are asked to reproduce intervals of stimuli that are intermixedly presented at various times, longer intervals are often underestimated and shorter intervals overestimated. This phenomenon may be attributed to the central tendency of time perception, and suggests that our brain optimally encodes a stimulus interval based on current stimulus input and prior knowledge of the distribution of stimulus intervals. Two distinct systems are thought to be recruited in the perception of sub- and supra-second intervals. Sub-second timing is subject to local sensory processing, whereas supra-second timing depends on more centralized mechanisms. To clarify the factors that influence time perception, the present study investigated how both sensory modality and timescale affect the central tendency. In Experiment 1, participants were asked to reproduce sub- or supra-second intervals, defined by visual or auditory stimuli. In the sub-second range, the magnitude of the central tendency was significantly larger for visual intervals compared to auditory intervals, while visual and auditory intervals exhibited a correlated and comparable central tendency in the supra-second range. In Experiment 2, the ability to discriminate sub-second intervals in the reproduction task was controlled across modalities by using an interval discrimination task. Even when the ability to discriminate intervals was controlled, visual intervals exhibited a larger central tendency than auditory intervals in the sub-second range. In addition, the magnitude of the central tendency for visual and auditory sub-second intervals was significantly correlated. These results suggest that a common modality-independent mechanism is responsible for the supra-second central tendency, and that both the modality-dependent and modality-independent components of the timing system contribute to the central tendency in the sub-second range.

Physical Properties of Gabbroic Rock Exposed in Oceanic Core Complexes- New Borehole Data From IODP Hole U1473A in the Indian Ocean and Prior Mid-Atlantic Ridge Results

NASA Astrophysics Data System (ADS)

Blackman, D. K.; Ildefonse, B.; Abe, N.; Harding, A. J.; Guerin, G.

2016-12-01

IODP Expedition 360 to Atlantis Bank on the Southwest Indian Ridge obtained physical property measurements of the 800 m section drilled into the footwall of the oceanic core complex. Compressional velocity (Vp) of core samples range from 5.9-7.2 km/s throughout the hole, with no simple relation to either basic rock type or alteration. Some intervals show a local trend, for example a general increase from 6.7-7.1 km/s over the interval 280-400 mbsf, above a major fault zone at 411-462 mbsf. Below the fault zone, core sample Vp is lower on average (6.6 km/s) than it is in the upper part of the hole (6.8 km/s). Some of this decrease is due to locally greater alteration, but higher oxide content also contributes. Borehole logs show lower Vp shallower than 400 m (6.3-6.4 km/s) and close match to olivine gabbro values below the fault zone, due to higher alteration levels and greater shallow fracturing. Local trends of decreasing Vp, over 10's of m correspond to increasing sample porosity within veined or fractured intervals. Porosities of core in Hole U1473A are low overall (<4.5%) and more variable above 570 mbsf than below. Electrical resistivity of the wallrock tracks logged velocity pattern, dropping below 100 ohm-m in altered or fractured intervals 20-50 m thick and rising over 1000 ohm-m where fresher rock was recovered. The range of velocity, density, and resistivity at Hole U1473A are similar to those in the other deep boreholes from Atlantis Bank (ODP Hole 735B, 1105A) and slightly higher than Vp in the gabbroic core of Atlantis Massif in the Atlantic, Hole U1309D. This may reflect erosion of the detachment zone when the bank was exposed at sealevel. Atlantis Massif displays an increase in Vp from the seafloor to a fault zone at 750 mbsf ( 4.0-6.2 km/s), followed by fairly constant values ( 6.7 km/s) at greater depths, interrupted by a highly altered olivine-rich troctolite interval 1080-1200 mbsf where velocity is up to 1 km/s slower. New analysis of seismic anisotropy based on sonic logs does not show any systematic signature for either core complex, but there are a few intervals up to 10 m thick where anisotropy due to local deformation or dominant fracture direction may be indicated. The new and prior borehole data will be presented in the context of available geophysical, lithologic and alteration results.

Impact of General Anesthesia on Safety and Outcomes in the Endovascular Arm of Interventional Management of Stroke (IMS) III Trial.

PubMed

Abou-Chebl, Alex; Yeatts, Sharon D; Yan, Bernard; Cockroft, Kevin; Goyal, Mayank; Jovin, Tudor; Khatri, Pooja; Meyers, Phillip; Spilker, Judith; Sugg, Rebecca; Wartenberg, Katja E; Tomsick, Tom; Broderick, Joe; Hill, Michael D

2015-08-01

General anesthesia (GA) for endovascular therapy (EVT) of acute ischemic stroke may be associated with worse outcomes. The Interventional Management of Stroke III trial randomized patients within 3 hours of acute ischemic stroke onset to intravenous tissue-type plasminogen activator±EVT. GA use within 7 hours of stroke onset was recorded per protocol. Good outcome was defined as 90-day modified Rankin Scale ≤2. A multivariable analysis adjusting for dichotomized National Institutes of Health Stroke Scale (NIHSS; 8-19 versus ≥20), age, and time from onset to groin puncture was performed. Four hundred thirty-four patients were randomized to EVT, 269 (62%) were treated under local anesthesia and 147 (33.9%) under GA; 18 (4%) were undetermined. The 2 groups were comparable except for median baseline NIHSS (16 local anesthesia versus 18 GA; P<0.0001). The GA group was less likely to achieve a good outcome (adjusted relative risk, 0.68; confidence interval, 0.52-0.90; P=0.0056) and had increased in-hospital mortality (adjusted relative risk, 2.84; confidence interval, 1.65-4.91; P=0.0002). Those with medically indicated GA had worse outcomes (adjusted relative risk, 0.49; confidence interval, 0.30-0.81; P=0.005) and increased mortality (relative risk, 3.93; confidence interval, 2.18-7.10; P<0.0001) with a trend for higher mortality with routine GA. There was no significant difference in the adjusted risks of subarachnoid hemorrhage (P=0.32) or symptomatic intracerebral hemorrhage (P=0.37). GA was associated with worse neurological outcomes and increased mortality in the EVT arm; this was primarily true among patients with medical indications for GA. Relative risk estimates, though not statistically significant, suggest reduced risk for subarachnoid hemorrhage and symptomatic intracerebral hemorrhage under local anesthesia. Although the reasons for these associations are not clear, these data support the use of local anesthesia when possible during EVT. URL: http://www.clinicaltrials.gov. Unique identifier: NCT00359424. © 2015 American Heart Association, Inc.

Delta of the local ventriculo-atrial intervals at the septal location to differentiate tachycardia using septal accessory pathways from atypical atrioventricular nodal re-entry.

PubMed

Calvo, David; Pérez, Diego; Rubín, José; García, Daniel; Ávila, Pablo; Javier García-Fernández, F; Pachón, Marta; Bravo, Loreto; Hernández, Jesús; Miracle, Ángel L; Valverde, Irene; Gozalez-Vasserot, Mar; Árias, Miguel Ángel; Jimenez-Candíl, Javier; Morís, César

2018-01-02

Tachycardia mediated by septal accessory pathways (AP) and atypical atrioventricular nodal re-entry (AVNRT) require careful electrophysiologic evaluation for differential diagnosis. We aim to describe the differential behaviour of local ventriculo-atrial (VA) intervals which predicts the tachycardia mechanism. The local VA intervals at the para-Hisian septum were measured under three different situations: (i) tachycardia; (ii) sustained entrainment from the right ventricular apex (RVA); and (iii) continuous pacing from the RVA during sinus rhythm. Differences were computed as follows: Δ-VAentr = VA during entrainment - VA during tachycardia; and Δ-VApac = VA while pacing during sinus rhythm - VA during tachycardia. In contrast to AVNRT, we hypothesized that an invariable retrograde conduction through the septal AP will keep the result of the subtractions close to 0 ms in cases of ortodromic atrioventricular re-entrant tachycardia (AVRT). We analysed 55 atypical AVNRT (45% posterior type) and 82 AVRT (10 anteroseptal, 18 para-Hisian, 12 mid-septal, and 42 posteroseptal). Δ-VAentr was longer for AVNRT (98.5 ± 40.3 ms) compared with septal AP (-5.7 ± 19.3 ms; P < 0.001). A value of 50 ms showed 98.7% sensitivity and 92% specificity (AUC 0.99; 95% CI 0.98-1). According to physiological criteria, a negative Δ-VAentr remains unobserved in the case of AVNRT (positive predictive value 100% for septal AP). Δ-VApac was also longer for AVNRT (66.5 ± 14.6 ms) compared with septal AP (-9.7 ± 3.3 ms; P < 0.001). A value of 50 ms showed 100% sensitivity and 74% specificity (AUC 0.86; 95% CI 0.76-0.93). Delta of the local VA intervals enables distinction between atypical AVNRT and AVRT mediated by septal AP. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2018. For permissions, please email: journals.permissions@oup.com.

Can mumps vaccine induce remission in recurrent respiratory papilloma?

PubMed

Pashley, Nigel R T

2002-07-01

To describe our experience using laser excision and locally injected mumps vaccine to induce remission in patients with recurrent respiratory papilloma (RRP). Tertiary care regional medical center. Initially, 11 children with RRP treated in a pilot study with laser excision at regular intervals for at least a year without adjuvant therapy; later, a series of 18 children and 20 adults with RRP, some of whom had used various adjuvant therapy with interval laser excision. Both patient groups continued their same interval laser excision with the same or similar laser, same clinical setting, and same surgeon. Locally injected mumps vaccine was then administered into the excision site after each laser removal of papilloma. Larynx and trachea were microphotographed with each treatment. Two consecutive disease-free intervals and a follow-up of at least 1 year were required criteria for remission. In the pilot study, remission was induced in 9 (82%) of 11 patients by 1 to 10 injections, with follow-up of 5 to 19 years. In the subsequent series, remission was induced in 29 (76%) of 38 patients by 4 to 26 injections, and follow-up was 2 to 5 years. Combined with serial laser excision, mumps vaccine positively influences induction of remission in children with RRP. The mechanisms of this effect are unclear, but the treatment is readily available, inexpensive, and has a low risk of adverse effects.

The Friedreich ataxia critical region spans a 150-kb interval on chromosome 9q13

DOE Office of Scientific and Technical Information (OSTI.GOV)

Montermini, L.; Zara, F.; Patel, P.I.

1995-11-01

By analysis of crossovers in key recombinant families and by homozygosity analysis of inbred families, the Friedreich ataxia (FRDA) locus was localized in a 300-kb interval between the X104 gene and the microsatellite marker FR8 (D9S888). By homology searches of the sequence databases, we identified X104 as the human tight junction protein ZO-2 gene. We generated a large-scale physical map of the FRDA region by pulsed-field gel electrophoresis analysis of genomic DNA and of three YAC clones derived from different libraries, and we constructed an uninterrupted cosmid contig spanning the FRDA locus. The cAMP-dependent protein kinase {gamma}-catalytic subunit gene wasmore » identified within the critical FRDA interval, but it was excluded as candidate because of its biological properties and because of lack of mutations in FRDA patients. Six new polymorphic markers were isolated between FR2 (D9S886) and FR8 (D9S888), which were used for homozygosity analysis in a family in which parents of an affected child are distantly related. An ancient recombination involving the centromeric FRDA flanking markers had been previously demonstrated in this family. Homozygosity analysis indicated that the FRDA gene is localized in the telomeric 150 kb of the FR2-FR8 interval. 17 refs., 3 figs., 1 tab.« less

Effectiveness of local therapy for stage I non-small-cell lung cancer in nonagenarians.

PubMed

Arnold, Brian N; Thomas, Daniel C; Rosen, Joshua E; Salazar, Michelle C; Detterbeck, Frank C; Blasberg, Justin D; Boffa, Daniel J; Kim, Anthony W

2017-09-01

Stage I non-small-cell lung cancer is potentially curable, yet older patients undergo treatment at lower rates than younger patients. This analysis sought to describe the treatment outcomes of nonagenarians with stage I non-small-cell lung cancer to better guide treatment decisions in this population. The National Cancer DataBase was queried for patients age ≥90 years old with stage I non-small-cell lung cancer (tumors ≤4 cm). Patients were divided into 3 groups: local therapy, other therapy, or no treatment. The primary outcomes were 5-year overall and relative survival. Of the 616 patients identified, 33% (202) were treated with local therapy, 34% (207) were treated with other therapy, and 34% (207) underwent no treatment. Compared with local therapy, overall mortality was significantly higher with no treatment (hazard ratio 2.50, 95% confidence interval, 1.95-3.21) and other therapy (hazard ratio 1.43, 95% confidence interval, 1.11-1.83). The 5-year relative survival was 81% for local therapy, 49% for other therapy, and 32% for no treatment (P < .0001). Nonagenarians managed with local therapy for stage I non-small-cell lung cancer (tumors ≤4 cm) have better overall survival than those receiving other therapy or no treatment and should be considered for treatment with either operation or stereotactic body radiation therapy if able to tolerate treatment. Copyright © 2017 Elsevier Inc. All rights reserved.

Effects of practice on variability in an isochronous serial interval production task: asymptotical levels of tapping variability after training are similar to those of musicians.

PubMed

Madison, Guy; Karampela, Olympia; Ullén, Fredrik; Holm, Linus

2013-05-01

Timing permeates everyday activities such as walking, dancing and music, yet the effect of short-term practice in this ubiquitous activity is largely unknown. In two training experiments involving sessions spread across several days, we examined short-term practice effects on timing variability in a sequential interval production task. In Experiment 1, we varied the mode of response (e.g., drumstick and finger tapping) and the level of sensory feedback. In Experiment 2 we varied the interval in 18 levels ranging from 500 ms to 1624 ms. Both experiments showed a substantial decrease in variability within the first hour of practice, but little thereafter. This effect was similar across mode of response, amount of feedback, and interval duration, and was manifested as a reduction in both local variability (between neighboring intervals) and drift (fluctuation across multiple intervals). The results suggest mainly effects on motor implementation rather than on cognitive timing processes, and have methodological implications for timing studies that have not controlled for practice. Copyright © 2013 Elsevier B.V. All rights reserved.

CLSI-derived hematology and biochemistry reference intervals for healthy adults in eastern and southern Africa.

PubMed

Karita, Etienne; Ketter, Nzeera; Price, Matt A; Kayitenkore, Kayitesi; Kaleebu, Pontiano; Nanvubya, Annet; Anzala, Omu; Jaoko, Walter; Mutua, Gaudensia; Ruzagira, Eugene; Mulenga, Joseph; Sanders, Eduard J; Mwangome, Mary; Allen, Susan; Bwanika, Agnes; Bahemuka, Ubaldo; Awuondo, Ken; Omosa, Gloria; Farah, Bashir; Amornkul, Pauli; Birungi, Josephine; Yates, Sarah; Stoll-Johnson, Lisa; Gilmour, Jill; Stevens, Gwynn; Shutes, Erin; Manigart, Olivier; Hughes, Peter; Dally, Len; Scott, Janet; Stevens, Wendy; Fast, Pat; Kamali, Anatoli

2009-01-01

Clinical laboratory reference intervals have not been established in many African countries, and non-local intervals are commonly used in clinical trials to screen and monitor adverse events (AEs) among African participants. Using laboratory reference intervals derived from other populations excludes potential trial volunteers in Africa and makes AE assessment challenging. The objective of this study was to establish clinical laboratory reference intervals for 25 hematology, immunology and biochemistry values among healthy African adults typical of those who might join a clinical trial. Equal proportions of men and women were invited to participate in a cross sectional study at seven clinical centers (Kigali, Rwanda; Masaka and Entebbe, Uganda; two in Nairobi and one in Kilifi, Kenya; and Lusaka, Zambia). All laboratories used hematology, immunology and biochemistry analyzers validated by an independent clinical laboratory. Clinical and Laboratory Standards Institute guidelines were followed to create study consensus intervals. For comparison, AE grading criteria published by the U.S. National Institute of Allergy and Infectious Diseases Division of AIDS (DAIDS) and other U.S. reference intervals were used. 2,990 potential volunteers were screened, and 2,105 (1,083 men and 1,022 women) were included in the analysis. While some significant gender and regional differences were observed, creating consensus African study intervals from the complete data was possible for 18 of the 25 analytes. Compared to reference intervals from the U.S., we found lower hematocrit and hemoglobin levels, particularly among women, lower white blood cell and neutrophil counts, and lower amylase. Both genders had elevated eosinophil counts, immunoglobulin G, total and direct bilirubin, lactate dehydrogenase and creatine phosphokinase, the latter being more pronounced among women. When graded against U.S. -derived DAIDS AE grading criteria, we observed 774 (35.3%) volunteers with grade one or higher results; 314 (14.9%) had elevated total bilirubin, and 201 (9.6%) had low neutrophil counts. These otherwise healthy volunteers would be excluded or would require special exemption to participate in many clinical trials. To accelerate clinical trials in Africa, and to improve their scientific validity, locally appropriate reference ranges should be used. This study provides ranges that will inform inclusion criteria and evaluation of adverse events for studies in these regions of Africa.

Geodynamic Evolution of Subduction to Collision to Escape in Central Anatolia From Surface to Mantle - Results From the CD-CAT Project

NASA Astrophysics Data System (ADS)

Darin, Michael

2017-04-01

Despite significant progress toward understanding the kinematics of modern tectonic escape in Anatolia, considerable uncertainty remains regarding the dynamics of the transition from collision to escape. Because of the relatively small size of the Anatolia microplate, regional-scale studies spanning the plate margins and interior are well-suited to investigate the driving forces and space-time evolution of this unique tectonic transition in collisional orogens. CD-CAT (Continental Dynamics-Central Anatolia Tectonics) is a five-year (2011-2016) project funded by the National Science Foundation (USA) designed to explore the surface-to-mantle dynamics of Anatolia during the Cenozoic subduction-collision-escape transition in central Anatolia. Our approach integrates results from a diversity of methods including: structural, stratigraphic, and geomorphic analyses; magnetostratigraphy; low-temperature thermochronometry; Ar/Ar geochronology; geochemistry; passive seismic experiments (71 stations over two years); magnetotellurics; and numerical modeling. The principal results from this project include: recognition of a margin-wide magmatic lull from 40-20 Ma, followed by a southwestward migration of the initiation of magmatism toward and within the Central Anatolia Volcanic Province (CAVP); an early Miocene switch from contraction/transpression to extension/transtension in the Kırşehir and Niǧde Massifs, while contraction changed to late Miocene strike-slip deformation east of the Central Anatolian fault zone (CAFZ); rain shadow development due to uplift of the central Taurides 11-5 Ma; thin to absent lithospheric mantle beneath central Anatolia; the lack of an Arabia slab shallower than 800 km depth; and a change in the Cyprus slab from horizontal beneath the central Taurides and apparently fragmented beneath the CAVP, to very steeply dipping beneath the eastern Isparta Angle. The CAFZ lies along part of the Inner Tauride Suture (ITS) and represents a fundamental inherited lithosphere-scale structure that has accommodated contrasting magnitudes and styles of deformation to the east and west since Arabia collision. The coincidence of a similarly NNE-oriented lower plate boundary (Africa COB) or STEP fault between the Cyprus and Arabia slabs may have amplified the role of the CAFZ in controlling differential upper plate deformation. These findings support the following tectonic scenario: the first stage involved late Eocene to early Miocene horizontal subduction of the Afro-Arabia slab from central Anatolia to the Zagros, culminating in the final suturing of the Taurides and Pontides in Anatolia. The second stage occurred during the Miocene and involved the segmentation of the downgoing slab at the longitude of the CAFZ to form the Arabia slab in the east and the Cyprus slab in the west. North of Arabia, early Miocene rollback and foundering of the Arabia slab resulted in widespread volcanism, slab delamination beneath the eastern Taurides and eventual break-off and rapid sinking into the lower mantle starting at 15-10 Ma. North of Cyprus, initial rollback, steepening and breakup of the Cyprus slab are recorded by early Miocene upper plate extension and exhumation, followed by middle Miocene voluminous CAVP magmatism and uplift of the southern Taurides margin. The final stage involved a transition from diffuse to localized strain along transcurrent structures that have facilitated the westward escape of Anatolia since the latest Miocene-Pliocene.

Reestablishment of the Ancestral Cascades Arc in Western Nevada and Eastern California by Rollback of the Shallow Farallon Slab

NASA Astrophysics Data System (ADS)

Henry, C. D.; Cousens, B.; John, D. A.; Colgan, J. P.

2009-12-01

The character and even existence of an ancestral Tertiary Cascades arc in western Nevada and eastern California south of the modern arc are controversial. Based on extensive published and new data on the regional distribution, timing, style, and composition of magmatism, we conclude that an ancestral arc was established by WSW migration of magmatism into western NV and the northeastern Sierra Nevada in the Oligocene and Miocene as a result of progressive rollback of the shallow subducted slab. Magma migration started with the well-known southward sweep through NE NV and NW UT between ~46 and 36 Ma. By ~30 Ma, migration of the leading edge and central belt of activity was much more WSW, especially after removing younger ~E-W extension. Locally sourced, initially dispersed and small volume, intermediate to mafic lavas erupted in western NV and northeastern CA by ~30 Ma and the eastern Sierra Nevada by ~28 Ma, contemporaneous with the much more voluminous ignimbrite flare-up in central NV. As migration continued, the ignimbrite flare-up tapered off. A voluminous, NNW-trending, dominantly effusive volcanic belt developed by ~22-18 Ma in western NV and was continuous from the Bodie Hills (CA/NV) to the Warner Range (northeast CA) by ~16-15 Ma. The volcanic belt was dominated by intermediate to mafic magmas compositionally similar to those of the modern south Cascades arc but reflecting melting of an old, subduction-modified lithosphere (Cousens et al. 2008; Geosphere). Extensive middle Miocene bimodal rocks related to the Yellowstone hotspot cover these rocks in NW NV, NE CA, and SE OR, but 30-23 Ma, intermediate to mafic and lesser silicic rocks are voluminous wherever older rocks are exposed below the middle Miocene rocks. Between ~25 Ma and the present, magmatism migrated WSW at an average rate of ~8 km/Ma but was at least partly stepwise, as exemplified by an ~50 km westward step at 2 Ma in the Lassen area (Guffanti et al. 1990, JGR). The magmatic belt was as much as 250 km wide (present-day NE-SW, perpendicular to WSW migration) during much of its activity and only narrowed as it focused in western NV. In contrast, the ancestral Western Cascades arc in OR developed by ~35-40 Ma and persisted to the present as a narrow (≤50 km) belt nearly coincident with the modern Cascade arc. The Western Cascades and ancestral arc activity in NV and CA were misaligned by 100s of km and only became aligned during the ~2 Ma westward step. Misalignment suggests a major tear in the subducted slab near the OR-NV/CA border. Steep subduction was reestablished in OR by 35 Ma but only developed in NV/CA by progressive foundering of the shallow slab. Examining the magmatic record from past to present (WSW migration) complicates the question of what constituted an ancestral Cascades arc, e.g., what is the setting of the ignimbrite flare-up? In contrast, by examining the record from present to past and W to E, it is difficult to determine when and where the modern arc stopped being a continental volcanic arc. More important to address the existence of a southern ancestral Cascades arc is to comprehensively determine the distribution, timing, and origin of magmatism.

Factors influencing pre-hospital care time intervals in Iran: a qualitative study.

PubMed

Khorasani-Zavareh, Davoud; Mohammadi, Reza; Bohm, Katarina

2018-06-23

Pre-hospital time management provides better access to victims of road traffic crashes (RTCs) and can help minimize preventable deaths, injuries and disabilities. While most studies have been focused on measuring various time intervals in the pre-hospital phase, to our best knowledge there is no study exploring the barriers and facilitators that affects these various intervals qualitatively. The present study aimed to explore factors affecting various time intervals relating to road traffic incidents in the pre-hospital phase and provides suggestions for improvements in Iran. The study was conducted during 2013-2014 at both the national and local level in Iran. Overall, 18 face-to-face interviews with emergency medical services (EMS) personnel were used for data collection. Qualitative content analysis was employed to analyze the data. The most important barriers in relation to pre-hospital intervals were related to the manner of cooperation by members of the public with the EMS and their involvement at the crash scene, as well as to pre-hospital system factors, including the number and location of EMS facilities, type and number of ambulances and manpower. These factors usually affect how rapidly the EMS can arrive at the scene of the crash and how quickly victims can be transferred to hospital. These two categories have six main themes: notification interval; activation interval; response interval; on-scene interval; transport interval; and delivery interval. Despite more focus on physical resources, cooperation from members of the public needs to be taken in account in order to achieve better pre-hospital management of the various intervals, possibly through the use of public education campaigns.

Self-calibrating threshold detector

NASA Technical Reports Server (NTRS)

Barnes, J. R.; Huang, M. Y. (Inventor)

1980-01-01

A self calibrating threshold detector comprises a single demodulating channel which includes a mixer having one input receiving the incoming signal and another input receiving a local replica code. During a short time interval, an incorrect local code is applied to the mixer to incorrectly demodulate the incoming signal and to provide a reference level that calibrates the noise propagating through the channel. A sample and hold circuit is coupled to the channel for storing a sample of the reference level. During a relatively long time interval, the correct replica code provides an output level which ranges between the reference level and a maximum level that represents incoming signal presence and synchronism with the replica code. A summer substracts the stored sample reference from the output level to provide a resultant difference signal indicative of the acquisition of the expected signal.

Open Smart Energy Gateway (OpenSEG)

DOE Office of Scientific and Technical Information (OSTI.GOV)

The Open Smart Energy Gateway (OpenSEG) aims to provide near-real time smart meter data to consumers without the delays or latencies associated with it being transported to the utility data center and then back to the consumer's application. To do this, the gateway queries the local Smart Meter to which it is bound to get energy consumption information at pre-defined intervals (minimum interval is 4 seconds). OpenSEG then stores the resulting data internally for retrieval by an external application.

Preliminary Results From a Heavily Instrumented Engine Ice Crystal Icing Test in a Ground Based Altitude Test Facility

NASA Technical Reports Server (NTRS)

Flegel, Ashlie B.; Oliver, Michael J.

2016-01-01

Preliminary results from the Heavily Instrumented ALF503R-5 Engine test conducted in the NASA Glenn Research Center Propulsion Systems Laboratory will be discussed. The effects of ice crystal icing on a full scale engine is examined and documented. This model engine, serial number LF01, was used during the inaugural icing test in the PSL facility. The reduction of thrust (rollback) events experienced by this engine in flight were replicated in the facility. Limited instrumentation was used to detect icing. Metal temperature on the exit guide vanes and outer shroud and the load measurement were the only indicators of ice formation. The current study features a similar engine, serial number LF11, which is instrumented to characterize the cloud entering the engine, detect characterize ice accretion, and visualize the ice accretion in the region of interest.

Performance bounds on parallel self-initiating discrete-event

NASA Technical Reports Server (NTRS)

Nicol, David M.

1990-01-01

The use is considered of massively parallel architectures to execute discrete-event simulations of what is termed self-initiating models. A logical process in a self-initiating model schedules its own state re-evaluation times, independently of any other logical process, and sends its new state to other logical processes following the re-evaluation. The interest is in the effects of that communication on synchronization. The performance is considered of various synchronization protocols by deriving upper and lower bounds on optimal performance, upper bounds on Time Warp's performance, and lower bounds on the performance of a new conservative protocol. The analysis of Time Warp includes the overhead costs of state-saving and rollback. The analysis points out sufficient conditions for the conservative protocol to outperform Time Warp. The analysis also quantifies the sensitivity of performance to message fan-out, lookahead ability, and the probability distributions underlying the simulation.

KSC-2009-2019

NASA Image and Video Library

2009-03-11

CAPE CANAVERAL, Fla. – On Launch Pad 39A at NASA's Kennedy Space Center in Florida, space shuttle Discovery is revealed after the rotating service structure has been rolled back. The rollback is in preparation for Discovery's liftoff on the STS-119 mission with a crew of seven. The rotating structure provides protected access to the shuttle for changeout and servicing of payloads at the pad. After the RSS is rolled back, the orbiter is ready for fuel cell activation and external tank cryogenic propellant loading operations. The mission is the 28th to the International Space Station and the 125th space shuttle flight. Discovery will deliver the final pair of power-generating solar array wings and the S6 truss segment. Installation of S6 will signal the station's readiness to house a six-member crew for conducting increased science. Liftoff of Discovery is scheduled for 9:20 p.m. EDT on March 11. Photo credit: NASA/Kim Shiflett

OCO-2 Tower Roll Prior to Fairing Hoist

NASA Image and Video Library

2014-03-24

VANDENBERG AIR FORCE BASE, Calif. – At Space Launch Complex 2 on Vandenberg Air Force Base in California, workers prepare to hoist the fairing for NASA's Orbiting Carbon Observatory-2 mission, or OCO-2, seen in the background, into the gantry's environmental enclosure, or clean room, following the rollback of the mobile service tower. The fairing will protect OCO-2 during launch aboard a United Launch Alliance Delta II rocket from Space Launch Complex 2 in July. The observatory will collect precise global measurements of carbon dioxide in the Earth's atmosphere and provide scientists with a better idea of the chemical compound's impacts on climate change. Scientists will analyze this data to improve our understanding of the natural processes and human activities that regulate the abundance and distribution of this important atmospheric gas. To learn more about OCO-2, visit http://oco.jpl.nasa.gov. Photo credit: NASA/Randy Beaudoin

KSC-08pd3268

NASA Image and Video Library

2008-10-20

CAPE CANAVERAL, Fla. - Space shuttle Atlantis rolls away from Launch Pad 39A at NASA's Kennedy Space Center in Florida. First motion was at 6:48 a.m. EDT. In the background are the open rotating service structure and the fixed service structure topped by its 80-foot-tall lightning mast. Atlantis is rolling back to the Vehicle Assembly Building to await launch on its STS-125 mission to repair NASA's Hubble Space Telescope. Atlantis' targeted launch on Oct. 14 was delayed when a system that transfers science data from the orbiting observatory to Earth malfunctioned on Sept. 27. The new target launch date is under review. The space shuttle is mounted on a Mobile Launcher Platform and will be delivered to the Vehicle Assembly Building atop a crawler transporter. traveling slower than 1 mph during the 3.4-mile journey. The rollback is expected to take approximately six hours. Photo credit: NASA/Kim Shiflett

KSC-05PD-1148

NASA Technical Reports Server (NTRS)

2005-01-01

KENNEDY SPACE CENTER, FLA. Dwarfing the accompanying vehicles, Space Shuttle Discovery, resting on the Mobile Launcher Platform atop the Crawler/Transporter, heads along the crawlerway to the Vehicle Assembly Building (VAB). Discovery is rolling back from Launch Pad 39B (in the background). Once inside the VAB, Discovery will be demated from its External Tank and lifted into the transfer aisle. On or about June 7, Discovery will be lifted and attached to its new tank and Solid Rocket Boosters, which are already in the VAB. Only the 15th rollback in Space Shuttle Program history, the 4.2-mile journey allows additional modifications to be made to the External Tank prior to a safe Return to Flight. Discovery is expected to be rolled back to the launch pad in mid-June for Return to Flight mission STS-114. The launch window extends from July 13 to July 31.

KSC-05PD-1175

NASA Technical Reports Server (NTRS)

2005-01-01

KENNEDY SPACE CENTER, FLA. Space Shuttle Discovery, resting on the Mobile Launcher Platform, turns the corner on the crawlerway as it rolls back from Launch Pad 39B to the Vehicle Assembly Building (VAB) at NASAs Kennedy Space Center. Once inside the VAB, it will be demated from its External Tank and lifted into the transfer aisle. On or about June 7, Discovery will be attached to its new tank and Solid Rocket Boosters, which are already in the VAB. Only the 15th rollback in Space Shuttle Program history, the 4.2-mile journey allows additional modifications to be made to the External Tank prior to a safe Return to Flight. Discovery is expected to be rolled back to the launch pad in mid-June for Return to Flight mission STS-114. The launch window extends from July 13 to July 31. [Photo courtesy of Scott Andrews

KSC-03PD-2086

NASA Technical Reports Server (NTRS)

2003-01-01

KENNEDY SPACE CENTER, FLA. On Launch Complex 17-B, Cape Canaveral Air Force Station, the Delta II Heavy launch vehicle carrying the rover 'Opportunity' for the second Mars Exploration Rover mission is poised for launch after rollback of the Mobile Service Tower. Opportunity will reach Mars on Jan. 25, 2004. Together the two MER rovers, Spirit (launched June 10) and Opportunity, seek to determine the history of climate and water at two sites on Mars where conditions may once have been favorable to life. The rovers are identical. They will navigate themselves around obstacles as they drive across the Martian surface, traveling up to about 130 feet each Martian day. Each rover carries five scientific instruments including a panoramic camera and microscope, plus a rock abrasion tool that will grind away the outer surfaces of rocks to expose their interiors for examination. Each rovers prime mission is planned to last three months on Mars.

Delta II Heavy MER-B Prelaunch

NASA Image and Video Library

2003-07-07

On Launch Complex 17-B, Cape Canaveral Air Force Station, the Delta II Heavy launch vehicle carrying the rover "Opportunity" for the second Mars Exploration Rover mission is poised for launch after rollback of the Mobile Service Tower. Opportunity will reach Mars on Jan. 25, 2004. Together the two MER rovers, Spirit (launched June 10) and Opportunity, seek to determine the history of climate and water at two sites on Mars where conditions may once have been favorable to life. The rovers are identical. They will navigate themselves around obstacles as they drive across the Martian surface, traveling up to about 130 feet each Martian day. Each rover carries five scientific instruments including a panoramic camera and microscope, plus a rock abrasion tool that will grind away the outer surfaces of rocks to expose their interiors for examination. Each rover’s prime mission is planned to last three months on Mars.

Delta II Heavy MER-B - MST Rollback

NASA Image and Video Library

2003-07-07

The Mobile Service Tower is ready to be rolled back at Launch Complex 17-B, Cape Canaveral Air Force Station, to launch the Delta II Heavy launch vehicle carrying the rover "Opportunity" on the second Mars Exploration Rover mission. Opportunity will reach Mars on Jan. 25, 2004. Together the two MER rovers, Spirit (launched June 10) and Opportunity, seek to determine the history of climate and water at two sites on Mars where conditions may once have been favorable to life. The rovers are identical. They will navigate themselves around obstacles as they drive across the Martian surface, traveling up to about 130 feet each Martian day. Each rover carries five scientific instruments including a panoramic camera and microscope, plus a rock abrasion tool that will grind away the outer surfaces of rocks to expose their interiors for examination. Each rover’s prime mission is planned to last three months on Mars.

Checkpointing filesystem

DOEpatents

Gara, Alan G.; Giampapa, Mark E.; Steinmacher-Burow, Burkhard D.

2005-05-17

The present in invention is directed to a checkpointing filesystem of a distributed-memory parallel supercomputer comprising a node that accesses user data on the filesystem, the filesystem comprising an interface that is associated with a disk for storing the user data. The checkpointing filesystem provides for taking and checkpoint of the filesystem and rolling back to a previously taken checkpoint, as well as for writing user data to and deleting user data from the checkpointing filesystem. The checkpointing filesystem provides a recently written file allocation table (WFAT) for maintaining information regarding the user data written since a previously taken checkpoint and a recently deleted file allocation table (DFAT) for maintaining information regarding user data deleted from since the previously taken checkpoint, both of which are utilized by the checkpointing filesystem to take a checkpoint of the filesystem and rollback the filesystem to a previously taken checkpoint, as well as to write and delete user data from the checkpointing filesystem.

Evaluating and extending user-level fault tolerance in MPI applications

DOE PAGES

Laguna, Ignacio; Richards, David F.; Gamblin, Todd; ...

2016-01-11

The user-level failure mitigation (ULFM) interface has been proposed to provide fault-tolerant semantics in the Message Passing Interface (MPI). Previous work presented performance evaluations of ULFM; yet questions related to its programability and applicability, especially to non-trivial, bulk synchronous applications, remain unanswered. In this article, we present our experiences on using ULFM in a case study with a large, highly scalable, bulk synchronous molecular dynamics application to shed light on the advantages and difficulties of this interface to program fault-tolerant MPI applications. We found that, although ULFM is suitable for master–worker applications, it provides few benefits for more common bulkmore » synchronous MPI applications. Furthermore, to address these limitations, we introduce a new, simpler fault-tolerant interface for complex, bulk synchronous MPI programs with better applicability and support than ULFM for application-level recovery mechanisms, such as global rollback.« less

Performing aggressive code optimization with an ability to rollback changes made by the aggressive optimizations

DOEpatents

Gschwind, Michael K

2013-07-23

Mechanisms for aggressively optimizing computer code are provided. With these mechanisms, a compiler determines an optimization to apply to a portion of source code and determines if the optimization as applied to the portion of source code will result in unsafe optimized code that introduces a new source of exceptions being generated by the optimized code. In response to a determination that the optimization is an unsafe optimization, the compiler generates an aggressively compiled code version, in which the unsafe optimization is applied, and a conservatively compiled code version in which the unsafe optimization is not applied. The compiler stores both versions and provides them for execution. Mechanisms are provided for switching between these versions during execution in the event of a failure of the aggressively compiled code version. Moreover, predictive mechanisms are provided for predicting whether such a failure is likely.

KSC-99pp0863

NASA Image and Video Library

1999-07-19

Space Shuttle Columbia, sitting on its mobile launcher platform, is framed against the early morning sky after the rollback of the Rotating Service Structure on Launch Pad 39-B. Columbia waits for the launch of mission STS-93 July 20 at 12:36 a.m. EDT. The primary payload of STS-93 is the Chandra X-ray Observatory, which will allow scientists from around the world to study some of the most distant, powerful and dynamic objects in the universe. The new telescope is 20 to 50 times more sensitive than any previous X-ray telescope and is expected unlock the secrets of supernovae, quasars and black holes. The STS-93 crew numbers five: Commander Eileen M. Collins, Pilot Jeffrey S. Ashby, and Mission Specialists Steven A. Hawley (Ph.D.), Catherine G. Coleman (Ph.D.) and Michel Tognini of France, with the Centre National d'Etudes Spatiales (CNES). Collins is the first woman to serve as commander of a shuttle mission

KSC-05PD-0124

NASA Technical Reports Server (NTRS)

2005-01-01

KENNEDY SPACE CENTER, FLA. On Launch Pad 17-B, Cape Canaveral Air Force Station, Fla., the Boeing Delta II rocket carrying the Deep Impact spacecraft is bathed in light waiting for tower rollback before launch. Scheduled for liftoff at 1:47 p.m. EST today, Deep Impact will head for space and a rendezvous with Comet Tempel 1 when the comet is 83 million miles from Earth. After releasing a 3- by 3-foot projectile (impactor) to crash onto the surface July 4, 2005, Deep Impacts flyby spacecraft will reveal the secrets of the comets interior by collecting pictures and data of how the crater forms, measuring the craters depth and diameter as well as the composition of the interior of the crater and any material thrown out, and determining the changes in natural outgassing produced by the impact. It will send the data back to Earth through the antennas of the Deep Space Network. Deep Impact is a NASA Discovery mission.

KSC-99pp0862

NASA Image and Video Library

1999-07-19

Space Shuttle Columbia catches the rising sun after the rollback of the Rotating Service Structure on Launch Pad 39-B. Columbia waits for the launch of mission STS-93 July 20 at 12:36 a.m. EDT. The primary payload of STS-93 is the Chandra X-ray Observatory, which will allow scientists from around the world to study some of the most distant, powerful and dynamic objects in the universe. The new telescope is 20 to 50 times more sensitive than any previous X-ray telescope and is expected unlock the secrets of supernovae, quasars and black holes. The STS-93 crew numbers five: Commander Eileen M. Collins, Pilot Jeffrey S. Ashby, and Mission Specialists Steven A. Hawley (Ph.D.), Catherine G. Coleman (Ph.D.) and Michel Tognini of France, with the Centre National d'Etudes Spatiales (CNES). Collins is the first woman to serve as commander of a shuttle mission

KSC-99pp0864

NASA Image and Video Library

1999-07-19

The rollback of the Rotating Service Structure on launch Pad 39-B reveals Space Shuttle Columbia on its mobile launcher platform, waiting for the launch of mission STS-93 on July 20 at 12:36 a.m. EDT. The primary payload of STS-93 is the Chandra X-ray Observatory, which will allow scientists from around the world to study some of the most distant, powerful and dynamic objects in the universe. The new telescope is 20 to 50 times more sensitive than any previous X-ray telescope and is expected unlock the secrets of supernovae, quasars and black holes. The STS-93 crew numbers five: Commander Eileen M. Collins, Pilot Jeffrey S. Ashby, and Mission Specialists Steven A. Hawley (Ph.D.), Catherine G. Coleman (Ph.D.) and Michel Tognini of France, with the Centre National d'Etudes Spatiales (CNES). Collins is the first woman to serve as commander of a shuttle mission

KSC-2014-3086

NASA Image and Video Library

2014-06-30

VANDENBERG AIR FORCE BASE, Calif. – Nightfall on Space Launch Complex 2 at Vandenberg Air Force Base in California follows the rollback of the mobile service tower for launch of NASA's Orbiting Carbon Observatory-2, or OCO-2, aboard a United Launch Alliance Delta II rocket. Launch is scheduled for 5:56 a.m. EDT on July 1. OCO-2 is NASA’s first mission dedicated to studying atmospheric carbon dioxide, the leading human-produced greenhouse gas driving changes in Earth’s climate. OCO-2 will provide a new tool for understanding the human and natural sources of carbon dioxide emissions and the natural "sinks" that absorb carbon dioxide and help control its buildup. The observatory will measure the global geographic distribution of these sources and sinks and study their changes over time. To learn more about OCO-2, visit http://www.nasa.gov/oco2. Photo credit: NASA/Kim Shiflett

KSC-2014-3083

NASA Image and Video Library

2014-06-30

VANDENBERG AIR FORCE BASE, Calif. – Final preparations are underway for the launch of NASA's Orbiting Carbon Observatory-2, or OCO-2, aboard a United Launch Alliance Delta II rocket, following rollback of the mobile service tower on Space Launch Complex 2 on Vandenberg Air Force Base in California. Launch is scheduled for 5:56 a.m. EDT on July 1. OCO-2 is NASA’s first mission dedicated to studying atmospheric carbon dioxide, the leading human-produced greenhouse gas driving changes in Earth’s climate. OCO-2 will provide a new tool for understanding the human and natural sources of carbon dioxide emissions and the natural "sinks" that absorb carbon dioxide and help control its buildup. The observatory will measure the global geographic distribution of these sources and sinks and study their changes over time. To learn more about OCO-2, visit http://www.nasa.gov/oco2. Photo credit: NASA/Kim Shiflett

KSC-2014-3087

NASA Image and Video Library

2014-06-30

VANDENBERG AIR FORCE BASE, Calif. – At Vandenberg Air Force Base in California, the United Launch Alliance Delta II rocket carrying NASA's Orbiting Carbon Observatory-2, or OCO-2, awaits loading of its cryogenic propellants following rollback of the mobile service tower on Space Launch Complex 2. Launch is scheduled for 5:56 a.m. EDT on July 1. OCO-2 is NASA’s first mission dedicated to studying atmospheric carbon dioxide, the leading human-produced greenhouse gas driving changes in Earth’s climate. OCO-2 will provide a new tool for understanding the human and natural sources of carbon dioxide emissions and the natural "sinks" that absorb carbon dioxide and help control its buildup. The observatory will measure the global geographic distribution of these sources and sinks and study their changes over time. To learn more about OCO-2, visit http://www.nasa.gov/oco2. Photo credit: NASA/Kim Shiflett

KSC-2014-3075

NASA Image and Video Library

2014-06-30

VANDENBERG AIR FORCE BASE, Calif. – Nightfall on Space Launch Complex 2 at Vandenberg Air Force Base in California follows the rollback of the mobile service tower for launch of NASA's Orbiting Carbon Observatory-2, or OCO-2, aboard a United Launch Alliance Delta II rocket. Launch is scheduled for 5:56 a.m. EDT on July 1. OCO-2 is NASA’s first mission dedicated to studying atmospheric carbon dioxide, the leading human-produced greenhouse gas driving changes in Earth’s climate. OCO-2 will provide a new tool for understanding the human and natural sources of carbon dioxide emissions and the natural "sinks" that absorb carbon dioxide and help control its buildup. The observatory will measure the global geographic distribution of these sources and sinks and study their changes over time. To learn more about OCO-2, visit http://www.nasa.gov/oco2. Photo credit: NASA/Randy Beaudoin

KSC-2014-3069

NASA Image and Video Library

2014-06-30

VANDENBERG AIR FORCE BASE, Calif. – NASA's Orbiting Carbon Observatory-2, or OCO-2, is ready for launch aboard a United Launch Alliance Delta II rocket following rollback of the mobile service tower on Space Launch Complex 2 on Vandenberg Air Force Base in California. Launch is scheduled for 5:56 a.m. EDT on July 1. OCO-2 is NASA’s first mission dedicated to studying atmospheric carbon dioxide, the leading human-produced greenhouse gas driving changes in Earth’s climate. OCO-2 will provide a new tool for understanding the human and natural sources of carbon dioxide emissions and the natural "sinks" that absorb carbon dioxide and help control its buildup. The observatory will measure the global geographic distribution of these sources and sinks and study their changes over time. To learn more about OCO-2, visit http://www.nasa.gov/oco2. Photo credit: NASA/Randy Beaudoin

KSC-2014-3076

NASA Image and Video Library

2014-06-30

VANDENBERG AIR FORCE BASE, Calif. – Space Launch Complex 2 at Vandenberg Air Force Base in California is illuminated following the rollback of the mobile service tower, preparing the way for launch of NASA's Orbiting Carbon Observatory-2, or OCO-2, aboard a United Launch Alliance Delta II rocket. Launch is scheduled for 5:56 a.m. EDT on July 1. OCO-2 is NASA’s first mission dedicated to studying atmospheric carbon dioxide, the leading human-produced greenhouse gas driving changes in Earth’s climate. OCO-2 will provide a new tool for understanding the human and natural sources of carbon dioxide emissions and the natural "sinks" that absorb carbon dioxide and help control its buildup. The observatory will measure the global geographic distribution of these sources and sinks and study their changes over time. To learn more about OCO-2, visit http://www.nasa.gov/oco2. Photo credit: NASA/Randy Beaudoin

KSC-2014-3088

NASA Image and Video Library

2014-06-30

VANDENBERG AIR FORCE BASE, Calif. – Space Launch Complex 2 on Vandenberg Air Force Base in California is illuminated following the rollback of the mobile service tower, preparing the way for launch of NASA's Orbiting Carbon Observatory-2, or OCO-2, aboard a United Launch Alliance Delta II rocket. Launch is scheduled for 5:56 a.m. EDT on July 1. OCO-2 is NASA’s first mission dedicated to studying atmospheric carbon dioxide, the leading human-produced greenhouse gas driving changes in Earth’s climate. OCO-2 will provide a new tool for understanding the human and natural sources of carbon dioxide emissions and the natural "sinks" that absorb carbon dioxide and help control its buildup. The observatory will measure the global geographic distribution of these sources and sinks and study their changes over time. To learn more about OCO-2, visit http://www.nasa.gov/oco2. Photo credit: NASA/Kim Shiflett

KSC-2014-3072

NASA Image and Video Library

2014-06-30

VANDENBERG AIR FORCE BASE, Calif. – The United Launch Alliance Delta II rocket carrying NASA's Orbiting Carbon Observatory-2, or OCO-2, is ready for launch over the flame trench on Space Launch Complex 2 at Vandenberg Air Force Base in California following rollback of the mobile service tower. Launch is scheduled for 5:56 a.m. EDT on July 1. OCO-2 is NASA’s first mission dedicated to studying atmospheric carbon dioxide, the leading human-produced greenhouse gas driving changes in Earth’s climate. OCO-2 will provide a new tool for understanding the human and natural sources of carbon dioxide emissions and the natural "sinks" that absorb carbon dioxide and help control its buildup. The observatory will measure the global geographic distribution of these sources and sinks and study their changes over time. To learn more about OCO-2, visit http://www.nasa.gov/oco2. Photo credit: NASA/Randy Beaudoin

KSC-2014-3082

NASA Image and Video Library

2014-06-30

VANDENBERG AIR FORCE BASE, Calif. – NASA's Orbiting Carbon Observatory-2, or OCO-2, stands ready for launch aboard a United Launch Alliance Delta II rocket following rollback of the mobile service tower on Space Launch Complex 2 on Vandenberg Air Force Base in California. Launch is scheduled for 5:56 a.m. EDT on July 1. OCO-2 is NASA’s first mission dedicated to studying atmospheric carbon dioxide, the leading human-produced greenhouse gas driving changes in Earth’s climate. OCO-2 will provide a new tool for understanding the human and natural sources of carbon dioxide emissions and the natural "sinks" that absorb carbon dioxide and help control its buildup. The observatory will measure the global geographic distribution of these sources and sinks and study their changes over time. To learn more about OCO-2, visit http://www.nasa.gov/oco2. Photo credit: NASA/Kim Shiflett

KSC-2014-3070

NASA Image and Video Library

2014-06-30

VANDENBERG AIR FORCE BASE, Calif. – Final preparations are underway for the launch of NASA's Orbiting Carbon Observatory-2, or OCO-2, aboard a United Launch Alliance Delta II rocket, following rollback of the mobile service tower on Space Launch Complex 2 on Vandenberg Air Force Base in California. Launch is scheduled for 5:56 a.m. EDT on July 1. OCO-2 is NASA’s first mission dedicated to studying atmospheric carbon dioxide, the leading human-produced greenhouse gas driving changes in Earth’s climate. OCO-2 will provide a new tool for understanding the human and natural sources of carbon dioxide emissions and the natural "sinks" that absorb carbon dioxide and help control its buildup. The observatory will measure the global geographic distribution of these sources and sinks and study their changes over time. To learn more about OCO-2, visit http://www.nasa.gov/oco2. Photo credit: NASA/Randy Beaudoin

KSC-2014-3074

NASA Image and Video Library

2014-06-30

VANDENBERG AIR FORCE BASE, Calif. – At Vandenberg Air Force Base in California, the United Launch Alliance Delta II rocket carrying NASA's Orbiting Carbon Observatory-2, or OCO-2, awaits loading of its cryogenic propellants following rollback of the mobile service tower on Space Launch Complex 2. Launch is scheduled for 5:56 a.m. EDT on July 1. OCO-2 is NASA’s first mission dedicated to studying atmospheric carbon dioxide, the leading human-produced greenhouse gas driving changes in Earth’s climate. OCO-2 will provide a new tool for understanding the human and natural sources of carbon dioxide emissions and the natural "sinks" that absorb carbon dioxide and help control its buildup. The observatory will measure the global geographic distribution of these sources and sinks and study their changes over time. To learn more about OCO-2, visit http://www.nasa.gov/oco2. Photo credit: NASA/Randy Beaudoin

KSC01padig260

NASA Image and Video Library

2001-08-08

KENNEDY SPACE CENTER, Fla. -- Floodlights reveal the Space Shuttle Discovery after rollback of the Rotating Service Structure in preparation for launch on mission STS-105. Above the external tank, the “beanie cap” is poised, waiting for loading of the propellants. The cap, or vent hood, is on the end of the gaseous oxygen vent arm that allows gaseous oxygen vapors to vent away from the Space Shuttle. On the mission, Discovery will be transporting the Expedition Three crew and several payloads and scientific experiments to the ISS, including the Early Ammonia Servicer (EAS) tank. The EAS, which will support the thermal control subsystems until a permanent system is activated, will be attached to the Station during two spacewalks. The three-member Expedition Two crew will be returning to Earth aboard Discovery after a five-month stay on the Station. Launch is scheduled for 5:38 p.m. EDT Aug. 9

Efficient Tracing for On-the-Fly Space-Time Displays in a Debugger for Message Passing Programs

NASA Technical Reports Server (NTRS)

Hood, Robert; Matthews, Gregory

2001-01-01

In this work we describe the implementation of a practical mechanism for collecting and displaying trace information in a debugger for message passing programs. We introduce a trace format that is highly compressible while still providing information adequate for debugging purposes. We make the mechanism convenient for users to access by incorporating the trace collection in a set of wrappers for the MPI (message passing interface) communication library. We implement several debugger operations that use the trace display: consistent stoplines, undo, and rollback. They all are implemented using controlled replay, which executes at full speed in target processes until the appropriate position in the computation is reached. They provide convenient mechanisms for getting to places in the execution where the full power of a state-based debugger can be brought to bear on isolating communication errors.

Surface imprint of toroidal flow at retreating slab edges: The first geodetic evidence in the Calabrian subduction system

NASA Astrophysics Data System (ADS)

Palano, M.; Piromallo, C.; Chiarabba, C.

2017-01-01

Dense GPS observations can help Earth scientists to capture the surface imprint of mantle toroidal flow at slab edges. We document this process in the Calabrian subduction system, where the Ionian slab rollback took place during the past 30 Ma, following a stepwise process driven by migration of lithospheric tearing. We found rotation rates of 1.29°/Ma (counterclockwise) and 1.74°/Ma (clockwise), for poles located close to the northern and southern slab edges, respectively. These small-scale, opposite rotations occur along complex sets of active faults representing the present-day lithospheric expression of the tearing processes affecting the southeastward retreating Ionian slab at both edges. The observed rotations are likely still young and the process more immature at the northern tear, where it is unable to reorient mantle fabric and therefore is unseen by SKS splitting.

KSC-07pd2168

NASA Image and Video Library

2007-08-03

KENNEDY SPACE CENTER, FLA. -- Rollback of the mobile service tower, or gantry, from around the Delta II 7925 rocket is complete on Launch Pad 17A at Cape Canaveral Air Force Station. Equipped with three stages and nine strap-on solid rocket motors, the Delta II rocket packs plenty of punch for sending the Phoenix spacecraft on its way toward Mars. Launch is targeted for Aug. 4 during one of two opportunities for liftoff: 5:26 or 6:02 a.m. EDT. Phoenix will land in icy soils near the north polar, permanent ice cap of Mars and explore the history of the water in these soils and any associated rocks, while monitoring polar climate. Landing on Mars is planned in May 2008 on arctic ground where a mission currently in orbit, Mars Odyssey, has detected high concentrations of ice just beneath the top layer of soil. Photo credit: NASA/Jim Grossmann

KSC-06pd1980

NASA Image and Video Library

2006-08-29

KENNEDY SPACE CENTER, FLA. - A serene scene surrounds Space Shuttle Atlantis as it begins rolling off Launch Pad 39B to return to the Vehicle Assembly Building. First motion off the pad was at 10:04 a.m. EDT. The crawler is 131 feet long, 113 feet wide and 20 feet high. It weights 5.5 million pounds unloaded. The combined weight of crawler, mobile launcher platform and a space shuttle is 12 million pounds. Unloaded, the crawler moves at 2 mph. Loaded, the snail's pace slows to 1 mph. The rollback is a safety precaution as the area waits for the arrival of Tropical Storm Ernesto. The storm is forecast to be bringing 58-mph to 70-mph winds in the next 24 hours. The shuttle will be moved into high bay 2, on the southwest side of the VAB, for protection from the storm. Photo credit: NASA/Ken Thornsley

Response to treatment and interval to surgery after preoperative short-course radiotherapy in rectal cancer.

PubMed

García-Cabezas, Sonia; Rodríguez-Liñán, Milagrosa; Otero-Romero, Ana M; Bueno-Serrano, Carmen M; Gómez-Barbadillo, José; Palacios-Eito, Amalia

2016-10-01

Preoperative short-course radiotherapy with immediate surgery improves local control in patients with rectal cancer. Tumor responses are smaller than those described with radiochemotherapy. Preliminary data associate this lower response to the short period until surgery. The aim of this study is to analyze the response to preoperative short-course radiotherapy and its correlation with the interval to surgery especially analyzing patients with mesorectal fascia involvement. A total of 155 patients with locally advanced rectal cancer treated with preoperative radiotherapy (5×5Gy) were retrospectively analyzed. Tumor response in terms of rates of complete pathological response, downstaging, tumor regression grading and status of the circumferential resection margin were quantified. The mean interval from radiotherapy to surgery was 23 days. The rate of complete pathological response was 2.2% and 28% experienced downstaging (stage decreased). No differences between these rates and interval to surgery were detected. Eighty-eight patients had magnetic resonance imaging for staging (in 31 patients the mesorectal fascia was involved).The mean time to surgery in patients with involvement of the fascia and R0 surgery was 27 days and 16 days if R1 (P=.016). The cutoff of 20 days reached the highest probability of achieving a free circumferential resection margin between patients with mesorectal fascia involvement, with no statistically significant differences: RR 3.036 95% CI=(0.691-13.328), P=.06. After preoperative short-course radiotherapy, an interval>20 days enhances the likelihood of achieving a free circumferential resection margin in patients with mesorectal fascia involvement. Copyright © 2016 AEC. Publicado por Elsevier España, S.L.U. All rights reserved.

Effect of Time Interval Between Tumescent Local Anesthesia Infiltration and Start of Surgery on Operative Field Visibility in Hand Surgery Without Tourniquet.

PubMed

Bashir, Muhammad Mustehsan; Qayyum, Rehan; Saleem, Muhammad Hammad; Siddique, Kashif; Khan, Farid Ahmad

2015-08-01

To determine the optimal time interval between tumescent local anesthesia infiltration and the start of hand surgery without a tourniquet for improved operative field visibility. Patients aged 16 to 60 years who needed contracture release and tendon repair in the hand were enrolled from the outpatient clinic. Patients were randomized to 10-, 15-, or 25-minute intervals between tumescent anesthetic solution infiltration (0.18% lidocaine and 1:221,000 epinephrine) and the start of surgery. The end point of tumescence anesthetic infiltration was pale and firm skin. The surgical team was blinded to the time of anesthetic infiltration. At the completion of the procedure, the surgeon and the first assistant rated the operative field visibility as excellent, fair, or poor. We used logistic regression models without and with adjustment for confounding variables. Of the 75 patients enrolled in the study, 59 (79%) were males, 7 were randomized to 10-minute time intervals (further randomization was stopped after interim analysis found consistently poor operative field visibility), and 34 were randomized to the each of the 15- and 25-minute groups. Patients who were randomized to the 25-minute delay group had 29 times higher odds of having an excellent operative visual field than those randomized to the 15-minute delay group. After adjusting for age, sex, amount of tumescent solution infiltration, and duration of operation, the odds ratio remained highly significant. We found that an interval of 25 minutes provides vastly superior operative field visibility; 10-minute delay had the poorest results. Therapeutic I. Copyright © 2015 American Society for Surgery of the Hand. Published by Elsevier Inc. All rights reserved.

Prognostic factors for cases with no extracranial metastasis in whom brain metastasis is detected after resection of non-small cell lung cancer.

PubMed

Bae, Mi Kyung; Yu, Woo Sik; Byun, Go Eun; Lee, Chang Young; Lee, Jin Gu; Kim, Dae Joon; Chung, Kyung Young

2015-05-01

This study aimed to determine prognostic factors associated with postrecurrence survival in cases with postoperative brain metastasis but with no extracranial metastasis in non-small cell lung cancer (NSCLC). Between 1992 and 2012, a total of 2832 patients underwent surgical resection for NSCLC. Among those, 86 patients had postoperative brain metastasis as the initial recurrence. Those patients were retrospectively reviewed. The median follow-up time after the initial lung resection was 24.0 months (range, 2.0-126.0 months). The median overall survival after initial lung cancer resection was 25.0 months and the median overall postrecurrence survival was 11 months. An initial lesion of adenocarcinoma (hazard ratio, 0.548; 95% confidence interval, 0.318 to 0.946; p=0.031), non-pneumonectomy, and a disease-free interval longer than 10.0 months (hazard ratio, 0.565; 95% confidence interval, 0.321-0.995; p=0.048) from the initial lung resection to the diagnosis of brain metastasis positively related to a good postrecurrence survival. Solitary brain metastasis and a size of less than 3 cm for the largest brain lesion were also positive factors for postrecurrence survival. Systemic chemotherapy for brain metastasis (hazard ratio, 0.356; 95% confidence interval, 0.189-0.670; p=0.001) and local treatment of surgery and/or stereotactic radiosurgery (SRS) for brain lesions (hazard ratio, 0.321; 95% confidence interval, 0.138-0.747; p=0.008) were positive factors for better postrecurrence survival. In patients with brain metastasis after resection for NSCLC with no extracranial metastasis, adenocarcinoma histologic type, longer disease-free interval, systemic chemotherapy for brain metastasis and local treatment of surgery and/or SRS for brain metastasis are independent positive prognostic factors for postrecurrence survival. Copyright © 2015. Published by Elsevier Ireland Ltd.

Mono Lake excursion recorded in sediment of the Santa Clara Valley, California

USGS Publications Warehouse

Mankinen, Edward A.; Wentworth, Carl M.

2004-01-01

Two intervals recording anomalous paleomagnetic inclinations were encountered in the top 40 meters of research drill hole CCOC in the Santa Clara Valley, California. The younger of these two intervals has an age of 28,090 ± 330 radiocarbon years B.P. (calibrated age ∼32.8 ka). This age is in excellent agreement with the latest estimate for the Mono Lake excursion at the type locality and confirms that the excursion has been recorded by sediment in the San Francisco Bay region. The age of an anomalous inclination change below the Mono Lake excursion was not directly determined, but estimates of sedimentation rates indicate that the geomagnetic behavior it represents most likely occurred during the Mono Lake/Laschamp time interval (∼45–28 ka). If true, it may represent one of several recurring fluctuations of magnetic inclination during an interval of a weak geomagnetic dipole, behavior noted in other studies in the region.

The Rotator Interval – A Link Between Anatomy and Ultrasound

PubMed Central

Tamborrini, Giorgio; Möller, Ingrid; Bong, David; Miguel, Maribel; Marx, Christian; Müller, Andreas Marc; Müller-Gerbl, Magdalena

2017-01-01

Shoulder pathologies of the rotator cuff of the shoulder are common in clinical practice. The focus of this pictorial essay is to discuss the anatomical details of the rotator interval of the shoulder, correlate the anatomy with normal ultrasound images and present selected pathologies. We focus on the imaging of the rotator interval that is actually the anterosuperior aspect of the glenohumeral joint capsule that is reinforced externally by the coracohumeral ligament, internally by the superior glenohumeral ligament and capsular fibers which blend together and insert medially and laterally to the bicipital groove. In this article we demonstrate the capability of high-resolution musculoskeletal ultrasound to visualize the detailed anatomy of the rotator interval. MSUS has a higher spatial resolution than other imaging techniques and the ability to examine these structures dynamically and to utilize the probe for precise anatomic localization of the patient’s pain by sono-palpation. PMID:28845477

Pediatric reference intervals for general clinical chemistry components - merging of studies from Denmark and Sweden.

PubMed

Ridefelt, Peter; Hilsted, Linda; Juul, Anders; Hellberg, Dan; Rustad, Pål

2018-05-28

Reference intervals are crucial tools aiding clinicians when making medical decisions. However, for children such values often are lacking or incomplete. The present study combines data from separate pediatric reference interval studies of Denmark and Sweden in order to increase sample size and to include also pre-school children who were lacking in the Danish study. Results from two separate studies including 1988 healthy children and adolescents aged 6 months to 18 years of age were merged and recalculated. Eighteen general clinical chemistry components were measured on Abbott and Roche platforms. To facilitate commutability, the NFKK Reference Serum X was used. Age- and gender-specific pediatric reference intervals were defined by calculating 2.5 and 97.5 percentiles. The data generated are primarily applicable to a Nordic population, but could be used by any laboratory if validated for the local patient population.

The Rotator Interval - A Link Between Anatomy and Ultrasound.

PubMed

Tamborrini, Giorgio; Möller, Ingrid; Bong, David; Miguel, Maribel; Marx, Christian; Müller, Andreas Marc; Müller-Gerbl, Magdalena

2017-06-01

Shoulder pathologies of the rotator cuff of the shoulder are common in clinical practice. The focus of this pictorial essay is to discuss the anatomical details of the rotator interval of the shoulder, correlate the anatomy with normal ultrasound images and present selected pathologies. We focus on the imaging of the rotator interval that is actually the anterosuperior aspect of the glenohumeral joint capsule that is reinforced externally by the coracohumeral ligament, internally by the superior glenohumeral ligament and capsular fibers which blend together and insert medially and laterally to the bicipital groove. In this article we demonstrate the capability of high-resolution musculoskeletal ultrasound to visualize the detailed anatomy of the rotator interval. MSUS has a higher spatial resolution than other imaging techniques and the ability to examine these structures dynamically and to utilize the probe for precise anatomic localization of the patient's pain by sono-palpation.

Comparative Diagnostic Performance of Ultrasonography and 99mTc-Sestamibi Scintigraphy for Parathyroid Adenoma in Primary Hyperparathyroidism; Systematic Review and Meta- Analysis

PubMed

Nafisi Moghadam, Reza; Amlelshahbaz, Amir Pasha; Namiranian, Nasim; Sobhan-Ardekani, Mohammad; Emami-Meybodi, Mahmood; Dehghan, Ali; Rahmanian, Masoud; Razavi-Ratki, Seid Kazem

2017-12-28

Objective: Ultrasonography (US) and parathyroid scintigraphy (PS) with 99mTc-MIBI are common methods for preoperative localization of parathyroid adenomas but there discrepancies exist with regard to diagnostic accuracy. The aim of the study was to compare PS and US for localization of parathyroid adenoma with a systematic review and meta-analysis of the literature. Methods: Pub Med, Scopus (EMbase), Web of Science and the reference lists of all included studies were searched up to 1st January 2016. The search strategy was according PICO characteristics. Heterogeneity between the studies was accounted by P < 0.1. Point estimates were pooled estimate of sensitivity, specificity and positive predictive value of SPECT and ultrasonography with 99% confidence intervals (CIs) by pooling available data. Data analysis was performed using Meta-DiSc software (version 1.4). Results: Among 188 studies and after deletion of duplicated studies (75), a total of 113 titles and abstracts were studied. From these, 12 studies were selected. The meta-analysis determined a pooled sensitivity for scintigraphy of 83% [99% confidence interval (CI) 96.358 -97.412] and for ultra-sonography of 80% [99% confidence interval (CI) 76-83]. Similar results for specificity were also obtained for both approache. Conclusion: According this meta- analysis, there were no significant differences between the two methods in terms of sensitivity and specificity. There were overlaps in 99% confidence intervals. Also features of the two methods are similar. Creative Commons Attribution License

Surface geology of the northern Midway-Sunset Field and adjacent Temblor Range, Kern County, California

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wylie, A.S. Jr.; Sturm, D.H.; Gardiner, R.L.

1996-01-01

New surface mapping at a 1:12000 scale adjacent to the 2 billion barrel Midway Sunset Field has revealed complex intraformational stratigraphy within the upper Miocene Santa Margarita Formation (Tms). Locally known as the Potter and Spellacy Formations in the subsurface, these sandstone and conglomerate heavy oil reservoirs produce the majority of Midway Sunset daily production of 164,000 barrels of oil via thermal EOR processes. The Tms consists mostly of conglomerate inserted into the Belridge Diatomite (Tmb) interval. The stratigraphically lower intervals of the Tms clearly fill deeply incised valleys or submarine canyons cut into Tmb and locally into the underlyingmore » Antelope Shale (Tma). The basal intervals of Tms; are very coarse grained, containing boulders of granitic and metamorphic rock as large as 4 meters that were derived from the Salinian block west of the San Andreas Fault. The upper intervals of Tms are more sheet-like and interbedded containing clasts less than 50 cm in length. The incised valleys have a spacing of about one mile in outcrop, with a gap located in the area of the older Republic Sandstone (Tmr). Paleocurrents from Tms regionally suggest sediment transport to the northeast. The sedimentary structures of Tms suggest deposition in deep-water conditions, probably a slope (bathyal) setting. Shelf environments should have been present to the southwest (now stripped away by erosion) and submarine-fan and basin-floor environments to the northeast.« less

Surface geology of the northern Midway-Sunset Field and adjacent Temblor Range, Kern County, California

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wylie, A.S. Jr.; Sturm, D.H.; Gardiner, R.L.

1996-12-31

New surface mapping at a 1:12000 scale adjacent to the 2 billion barrel Midway Sunset Field has revealed complex intraformational stratigraphy within the upper Miocene Santa Margarita Formation (Tms). Locally known as the Potter and Spellacy Formations in the subsurface, these sandstone and conglomerate heavy oil reservoirs produce the majority of Midway Sunset daily production of 164,000 barrels of oil via thermal EOR processes. The Tms consists mostly of conglomerate inserted into the Belridge Diatomite (Tmb) interval. The stratigraphically lower intervals of the Tms clearly fill deeply incised valleys or submarine canyons cut into Tmb and locally into the underlyingmore » Antelope Shale (Tma). The basal intervals of Tms; are very coarse grained, containing boulders of granitic and metamorphic rock as large as 4 meters that were derived from the Salinian block west of the San Andreas Fault. The upper intervals of Tms are more sheet-like and interbedded containing clasts less than 50 cm in length. The incised valleys have a spacing of about one mile in outcrop, with a gap located in the area of the older Republic Sandstone (Tmr). Paleocurrents from Tms regionally suggest sediment transport to the northeast. The sedimentary structures of Tms suggest deposition in deep-water conditions, probably a slope (bathyal) setting. Shelf environments should have been present to the southwest (now stripped away by erosion) and submarine-fan and basin-floor environments to the northeast.« less

Some properties of negative cloud-to-ground flashes from observations of a local thunderstorm based on accurate-stroke-count studies

NASA Astrophysics Data System (ADS)

Zhu, Baoyou; Ma, Ming; Xu, Weiwei; Ma, Dong

2015-12-01

Properties of negative cloud-to-ground (CG) lightning flashes, in terms of number of strokes per flash, inter-stroke intervals and the relative intensity of subsequent and first strokes, were presented by accurate-stroke-count studies based on all 1085 negative flashes from a local thunderstorm. The percentage of single-stroke flashes and stroke multiplicity evolved significantly during the whole life cycle of the study thunderstorm. The occurrence probability of negative CG flashes decreased exponentially with the increasing number of strokes per flash. About 30.5% of negative CG flashes contained only one stroke and number of strokes per flash averaged 3.3. In a subset of 753 negative multiple-stroke flashes, about 41.4% contained at least one subsequent stroke stronger than the corresponding first stroke. Subsequent strokes tended to decrease in strength with their orders and the ratio of subsequent to first stroke peaks presented a geometric mean value of 0.52. Interestingly, negative CG flashes of higher multiplicity tended to have stronger initial strokes. 2525 inter-stroke intervals showed a more or less log-normal distribution and gave a geometric mean value of 62 ms. For CG flashes of particular multiplicity geometric mean inter-stroke intervals tended to decrease with the increasing number of strokes per flash, while those intervals associated with higher order strokes tended to be larger than those associated with low order strokes.

CLSI-based transference of CALIPER pediatric reference intervals to Beckman Coulter AU biochemical assays.

PubMed

Abou El Hassan, Mohamed; Stoianov, Alexandra; Araújo, Petra A T; Sadeghieh, Tara; Chan, Man Khun; Chen, Yunqi; Randell, Edward; Nieuwesteeg, Michelle; Adeli, Khosrow

2015-11-01

The CALIPER program has established a comprehensive database of pediatric reference intervals using largely the Abbott ARCHITECT biochemical assays. To expand clinical application of CALIPER reference standards, the present study is aimed at transferring CALIPER reference intervals from the Abbott ARCHITECT to Beckman Coulter AU assays. Transference of CALIPER reference intervals was performed based on the CLSI guidelines C28-A3 and EP9-A2. The new reference intervals were directly verified using up to 100 reference samples from the healthy CALIPER cohort. We found a strong correlation between Abbott ARCHITECT and Beckman Coulter AU biochemical assays, allowing the transference of the vast majority (94%; 30 out of 32 assays) of CALIPER reference intervals previously established using Abbott assays. Transferred reference intervals were, in general, similar to previously published CALIPER reference intervals, with some exceptions. Most of the transferred reference intervals were sex-specific and were verified using healthy reference samples from the CALIPER biobank based on CLSI criteria. It is important to note that the comparisons performed between the Abbott and Beckman Coulter assays make no assumptions as to assay accuracy or which system is more correct/accurate. The majority of CALIPER reference intervals were transferrable to Beckman Coulter AU assays, allowing the establishment of a new database of pediatric reference intervals. This further expands the utility of the CALIPER database to clinical laboratories using the AU assays; however, each laboratory should validate these intervals for their analytical platform and local population as recommended by the CLSI. Copyright © 2015 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

Clinical chemistry reference intervals of healthy adult populations in Gojjam Zones of Amhara National Regional State, Northwest Ethiopia.

PubMed

Mekonnen, Zewdie; Amuamuta, Asmare; Mulu, Wondemagegn; Yimer, Mulat; Zenebe, Yohannes; Adem, Yesuf; Abera, Bayeh; Gebeyehu, Wondemu; Gebregziabher, Yakob

2017-01-01

Reference interval is crucial for disease screening, diagnosis, monitoring, progression and treatment efficacy. Due to lack of locally derived reference values for the parameters, clinicians use reference intervals derived from western population. But, studies conducted in different African countries have indicated differences between locally and western derived reference values. Different studies also indicated considerable variation in clinical chemistry reference intervals by several variables such as age, sex, geographical location, environment, lifestyle and genetic variation. This study aimed to determine the reference intervals of common clinical chemistry parameters of the community of Gojjam Zones, Northwest Ethiopia. Population based cross-sectional study was conducted from November 2015 to December 2016 in healthy adult populations of Gojjam zone. Data such as, medical history, physical examination and socio-demographic data were collected. In addition, laboratory investigations were undertaken to screen the population. Clinical chemistry parameters were measured using Mindray BS 200 clinical chemistry autoanalyzer as per the manufacturer's instructions. Descriptive statistics was used to calculate mean, median and 95th percentiles. Independent sample T-test and one way ANOVA were used to see association between variables. After careful screening of a total of 799 apparently healthy adults who were consented for this study, complete data from 446 (224 females and 222 males) were included for the analysis. The mean age of both the study participants was 28.8 years. Males had high (P<0.05) mean and 2.5th-97.5th percentile ranges of ALT, AST, ALP, creatinine and direct bilirubin. The reference intervals of amylase, LDH, total protein and total bilirubin were not significantly different between the two sex groups (P>0.05). Mean, median, 95% percentile values of AST, ALP, amylase, LDH, creatinine, total protein, total bilirubin, and direct bilirubin across all age groups of participants were similar (P>0.05). But, there was a significant difference in the value of ALT (P<0.05). The reference intervals of ALT, total protein and creatinine were significantly (P<0.05) high in people having monthly income >1500 ETB compared to those with low monthly income. Significant (P<0.05) higher values of the ALT, ALP and total protein were observed in people living in high land compared to low land residences. The study showed that some of the common clinical chemistry parameters reference intervals of healthy adults in Gojjam zones were higher than the reference intervals generated from developed countries. Therefore, strict adherence to the reference values generated in developed countries could lead to inappropriate diagnosis and treatment of patients. There was also variation of reference interval values based on climate, gender, age, monthly income and geographical locations. Therefore, further study is required to establish reference intervals for Ethiopian population.

Localization of an Ataxia-Telangiectasia Gene to an −500-kb Interval on Chromosome 11q23.1: Linkage Analysis of 176 Families by an International Consortium

PubMed Central

Lange, Ethan; Borresen, Anna-Lise; Chen, Xiaoguang; Chessa, Luciana; Chiplunkar, Sujata; Concannon, Patrick; Dandekar, Sugandha; Gerken, Steven; Lange, Kenneth; Liang, Teresa; McConville, Carmel; Polakow, Jeff; Porras, Oscar; Rotman, Galit; Sanal, Ozden; Sheikhavandi, Sepideh; Shiloh, Yosef; Sobel, Eric; Taylor, Malcolm; Telatar, Milhan; Teraoka, Sharon; Tolun, Aslihan; Udar, Nitin; Uhrhammer, Nancy; Vanagaite, Lina; Wang, Zhijun; Wapelhorst, Beth; Wright, Jocyndra; Yang, Huan-Ming; Yang, Lan; Ziv, Yael; Gatti, Richard A.

1995-01-01

We describe a 20-point linkage analysis map of chromosome 11q22-23 that is based on genotyping 249 families (59 CEPH and 190 A-T). Monte Carlo linkage analyses of 176 ataxia-telangiectasia (A-T) families localizes the major A-T locus to the region between S1819(A4) and S1818(A2). When seven nonlinking families were excluded from subsequent analyses, a 2-lod support interval of ∼500 kb was identified between S1819(A4) and S1294. No recombinants were observed between A-T and markers S384, B7, S535, or S1294. Only 17 of the international consortium families have been assigned to complementation groups. The available evidence favors either a cluster of A-T genes on chromosome 11 or intragenic defects in a single gene. PMID:7611279

An algorithm for synchronizing a clock when the data are received over a network with an unstable delay

PubMed Central

Levine, Judah

2016-01-01

A method is presented for synchronizing the time of a clock to a remote time standard when the channel connecting the two has significant delay variation that can be described only statistically. The method compares the Allan deviation of the channel fluctuations to the free-running stability of the local clock, and computes the optimum interval between requests based on one of three selectable requirements: (1) choosing the highest possible accuracy, (2) choosing the best tradeoff of cost vs. accuracy, or (3) minimizing the number of requests to realize a specific accuracy. Once the interval between requests is chosen, the final step is to steer the local clock based on the received data. A typical adjustment algorithm, which supports both the statistical considerations based on the Allan deviation comparison and the timely detection of errors is included as an example. PMID:26529759

Dynamical behaviors of inter-out-of-equilibrium state intervals in Korean futures exchange markets

NASA Astrophysics Data System (ADS)

Lim, Gyuchang; Kim, SooYong; Kim, Kyungsik; Lee, Dong-In; Scalas, Enrico

2008-05-01

A recently discovered feature of financial markets, the two-phase phenomenon, is utilized to categorize a financial time series into two phases, namely equilibrium and out-of-equilibrium states. For out-of-equilibrium states, we analyze the time intervals at which the state is revisited. The power-law distribution of inter-out-of-equilibrium state intervals is shown and we present an analogy with discrete-time heat bath dynamics, similar to random Ising systems. In the mean-field approximation, this model reduces to a one-dimensional multiplicative process. By varying global and local model parameters, the relevance between volatilities in financial markets and the interaction strengths between agents in the Ising model are investigated and discussed.

FFT-local gravimetric geoid computation

NASA Technical Reports Server (NTRS)

Nagy, Dezso; Fury, Rudolf J.

1989-01-01

Model computations show that changes of sampling interval introduce only 0.3 cm changes, whereas zero padding provides an improvement of more than 5 cm in the fast Fourier transformation (FFT) generated geoid. For the Global Positioning System (GPS) survey of Franklin County, Ohio, the parameters selected as a result of model computations, allow large reduction in local data requirements while still retaining the cm accuracy when tapering and padding is applied. The results are shown in tables.

Cenozoic landforms and post-orogenic landscape evolution of the Balkanide orogen: Evidence for alternatives to the tectonic denudation narrative in southern Bulgaria

NASA Astrophysics Data System (ADS)

Gunnell, Y.; Calvet, M.; Meyer, B.; Pinna-Jamme, R.; Bour, I.; Gautheron, C.; Carter, A.; Dimitrov, D.

2017-01-01

Continental denudation is the mass transfer of rock from source areas to sedimentary depocentres, and is typically the result of Earth surface processes. However, a process known as tectonic denudation is also understood to expose deep-seated rocks in short periods of geological time by displacing large masses of continental crust along shallow-angle faults, and without requiring major contributions from surface erosion. Some parts of the world, such as the Basin and Range in the USA or the Aegean province in Europe, have been showcased for their Cenozoic tectonic denudation features, commonly described as metamorphic core-complexes or as supradetachment faults. Based on 22 new apatite fission-track (AFT) and 21 helium (AHe) cooling ages among rock samples collected widely from plateau summits and their adjacent valley floors, and elaborating on inconsistencies between the regional stratigraphic, topographic and denudational records, this study frames a revised perspective on the prevailing tectonic denudation narrative for southern Bulgaria. We conclude that conspicuous landforms in this region, such as erosion surfaces on basement-cored mountain ranges, are not primarily the result of Paleogene to Neogene core-complex formation. They result instead from "ordinary" erosion-driven, subaerial denudation. Rock cooling, each time suggesting at least 2 km of crustal denudation, has exposed shallow Paleogene granitic plutons and documents a 3-stage wave of erosional denudation which progressed from north to south during the Middle Eocene, Oligocene, Early to Middle Miocene, and Late Miocene. Denudation initially prevailed during the Paleogene under a syn-orogenic compressional regime involving piggyback extensional basins (Phase 1), but subsequently migrated southward in response to post-orogenic upper-plate extension driven by trench rollback of the Hellenic subduction slab (Phase 2). Rare insight given by the denudation pattern indicates that trench rollback progressed at a mean velocity of 3 to 4 km/Ma. The Neogene horst-and-graben mosaic that defines the modern landscape (Phase 3) has completely overprinted the earlier fabrics of Phases 1 and 2, and has been the prime focus of tectonic geomorphologists working in the region. The new narrative proposed here for linking the geodynamic evolution of SE Europe with surface landform assemblages raises issues in favour of better documenting the regional sedimentary record of existing Paleogene basins, which constitute a poorly documented missing link to the thermochronological evidence presented here.

Dynamics of subduction, accretion, exhumation and slab roll-back: Mediterranean scenarios

NASA Astrophysics Data System (ADS)

Tirel, C.; Brun, J.; Burov, E. B.; Wortel, M. J.; Lebedev, S.

2010-12-01

A dynamic orogen reveals various tectonic processes brought about by subduction: accretion of oceanic and continental crust, exhumation of UHP-HP rocks, and often, back-arc extension. In the Mediterranean, orogeny is strongly affected by slab retreat, as in the Aegean and Tyrrhenian Seas. In order to examine the different dynamic processes in a self-consistent manner, we perform a parametric study using the fully coupled thermo-mechanical numerical code PARAFLAM. The experiments reproduce a subduction zone in a slab pull mode, with accretion of one (the Tyrrhenian case) and two continental blocks (the Aegean case) that undergo, in sequence, thrusting, burial and exhumation. The modeling shows that despite differences in structure between the two cases, the deformation mechanisms are fundamentally similar and can be described as follows. The accretion of a continental block at the trench beneath the suture zone begins with its burial to UHP-HP conditions and thrusting. Then the continental block is delaminated from its subducting lithosphere. During the subduction-accretion process, the angle of the subducting slab increases due to the buoyancy of the continental block. When the oceanic subduction resumes, the angle of the slab decreases to reach a steady-state position. The Aegean and Tyrrhenian scenarios diverge at this stage, due naturally to the differences of their accretion history. When continental accretion is followed by oceanic subduction only, the continental block that has been accreted and detached stays at close to the trench and does not undergo further deformation, despite the continuing rollback. The extensional deformation is located further within the overriding plate, resulting in continental breakup and the development of an oceanic basin, as in the Tyrrhenian domain. When the continental accretion is followed first by oceanic subduction and then by accretion of another continental block, however, the evolution of the subduction zone is different. The angle of the subducting slab increases again, following the arrival of the second continental block. The first continental block is now disconnected from the trench and is strongly heated by the asthenosphere that rises to just below the Moho. The locus of extension, originally in the overriding plate, moves to the first continental block, resulting in the development of metamorphic core complexes, as in the Aegean domain. Simultaneously, the second continent undergoes burial to UHP-HP conditions, thrusting and exhumation.

Subduction zone evolution and low viscosity wedges and channels

NASA Astrophysics Data System (ADS)

Manea, Vlad; Gurnis, Michael

2007-12-01

Dehydration of subducting lithosphere likely transports fluid into the mantle wedge where the viscosity is decreased. Such a decrease in viscosity could form a low viscosity wedge (LVW) or a low viscosity channel (LVC) on top of the subducting slab. Using numerical models, we investigate the influence of low viscosity wedges and channels on subduction zone structure. Slab dip changes substantially with the viscosity reduction within the LVWs and LVCs. For models with or without trench rollback, overthickening of slabs is greatly reduced by LVWs or LVCs. Two divergent evolutionary pathways have been found depending on the maximum depth extent of the LVW and wedge viscosity. Assuming a viscosity contrast of 0.1 with background asthenosphere, models with a LVW that extends down to 400 km depth show a steeply dipping slab, while models with an LVW that extends to much shallower depth, such as 200 km, can produce slabs that are flat lying beneath the overriding plate. There is a narrow range of mantle viscosities that produces flat slabs (5 to10 × 10 19 Pa s) and the slab flattening process is enhanced by trench rollback. Slab can be decoupled from the overriding plate with a LVC if the thickness is at least a few 10 s of km, the viscosity reduction is at least a factor of two and the depth extent of the LVC is several hundred km. These models have important implications for the geochemical and spatial evolution of volcanic arcs and the state of stress within the overriding plate. The models explain the poor correlation between traditional geodynamic controls, subducting plate age and convergence rates, on slab dip. We predict that when volcanic arcs change their distance from the trench, they could be preceded by changes in arc chemistry. We predict that there could be a larger volatile input into the wedge when arcs migrate toward the trench and visa-versa. The transition of a subduction zone into the flat-lying regime could be preceded by changes in the volatile budget such that the dehydration front moves to shallower depths. Our flat-slab models shed some light on puzzling flat subduction systems, like in Central Mexico, where there is no deformation within the overriding plate above the flat segment. The lack of in-plane compression in Central Mexico suggests the presence of a low viscosity shear zone above the flat slab.

Performance of the local health system and contingent influences in Northeast-Brazil: breaking vicious and virtuous circles

PubMed Central

Medeiros, Regianne Leila Rolim; Atkinson, Sarah

2015-01-01

Organizational theory has long emphasized the importance of contingent, environmental influences on organizational performance. Similarly, research has demonstrated the importance of local political culture and informal management on the performance of the local health system, establishing vicious and virtuous circles of influence that contribute to increasing inequalities in performance among decentralized local health systems. A longitudinal ethnography studied the relationship between these elements in the same rural municipality in Northeast Brazil after a four-year interval. The second study found the local health system performance much improved. Two main factors appear to have interacted to bring this about: leadership vision and power to implement of one individual; professionalization of the local health system by hiring a significant number of senior health staff. The origins of these influences combine initiatives at local, state and federal levels. PMID:24196907

Sampling and Control Circuit Board for an Inertial Measurement Unit

NASA Technical Reports Server (NTRS)

Chelmins, David T (Inventor); Sands, Obed (Inventor); Powis, Richard T., Jr. (Inventor)

2016-01-01

A circuit board that serves as a control and sampling interface to an inertial measurement unit ("IMU") is provided. The circuit board is also configured to interface with a local oscillator and an external trigger pulse. The circuit board is further configured to receive the external trigger pulse from an external source that time aligns the local oscillator and initiates sampling of the inertial measurement device for data at precise time intervals based on pulses from the local oscillator. The sampled data may be synchronized by the circuit board with other sensors of a navigation system via the trigger pulse.

Weak climatic control of stand-scale fire history during the late holocene.

PubMed

Gavin, Daniel G; Hu, Feng Sheng; Lertzman, Kenneth; Corbett, Peter

2006-07-01

Forest fire occurrence is affected by multiple controls that operate at local to regional scales. At the spatial scale of forest stands, regional climatic controls may be obscured by local controls (e.g., stochastic ignitions, topography, and fuel loads), but the long-term role of such local controls is poorly understood. We report here stand-scale (<100 ha) fire histories of the past 5000 years based on the analysis of sediment charcoal at two lakes 11 km apart in southeastern British Columbia. The two lakes are today located in similar subalpine forests, and they likely have experienced the same late-Holocene climatic changes because of their close proximity. We evaluated two independent properties of fire history: (1) fire-interval distribution, a measure of the overall incidence of fire, and (2) fire synchroneity, a measure of the co-occurrence of fire (here, assessed at centennial to millennial time scales due to the resolution of sediment records). Fire-interval distributions differed between the sites prior to, but not after, 2500 yr before present. When the entire 5000-yr period is considered, no statistical synchrony between fire-episode dates existed between the two sites at any temporal scale, but for the last 2500 yr marginal levels of synchrony occurred at centennial scales. Each individual fire record exhibited little coherency with regional climate changes. In contrast, variations in the composite record (average of both sites) matched variations in climate evidenced by late-Holocene glacial advances. This was probably due to the increased sample size and spatial extent represented by the composite record (up to 200 ha) plus increased regional climatic variability over the last several millennia, which may have partially overridden local, non-climatic controls. We conclude that (1) over past millennia, neighboring stands with similar modern conditions may have experienced different fire intervals and asynchronous patterns in fire episodes, likely because local controls outweighed the synchronizing effect of climate; (2) the influence of climate on fire occurrence is more strongly expressed when climatic variability is relatively great; and (3) multiple records from a region are essential if climate-fire relations are to be reliably described.

Early sexual maturity in local boars of Northeastern India: age-related changes in testicular growth, epididymal sperm characteristics and peripheral testosterone levels.

PubMed

Kumaresan, A; Bujarbaruah, K M; Kadirvel, G; Khargharia, G; Sarma, Rumi G; Goswami, J; Basumatary, Rantu; Palaniappan, Kavitha; Bardoloi, R K

2011-03-01

The present study reports the age related changes in the peripheral testosterone levels, testicular and epididymal growth and development and cauda epididymal spermiogram in local pigs of Northeastern India, which attain sexual maturity around 3 months of age. Local boars (n = 20) were castrated at monthly intervals from 2 to 6 months of age (4 boars per month) to study the testicular growth and development and the epididymal spermiogram. Blood samples, collected from local boars (n = 6) at monthly intervals from 2 to 6 months of age, were analyzed for testosterone levels by radioimmunoassay. Compared to Hampshire boars, significantly (P < 0.05) high testosterone levels were observed in the local boars as early as 2 months of age. The mean (± SEM) level of testosterone in the local boars at 2, 3 and 4 months of age was 11.89 ± 1.52, 20.45 ± 1.33 and 20.38 ± 2.0 ngml(-1), respectively. Though there was consistently significant (P < 0.05) difference in the body weight between Hampshire and local pigs, the same was not observed in case of testicular weight except at 3 and 6 months of age. In line with the above observation, the testis:body weight ratio (gram testis per kg body weight) was significantly (P < 0.05) higher in the local boars compared to the Hampshire boars at any time of observation, which ranged from 0.8 to 1.0 in case of Hampshire and from 2.3 to 3.0 in local boars. The sperm concentration in the cauda epididymal fluid of local boars at 2, 3 and 6 months of age was 2255 ± 186.6, 3685 ± 103.8 and 4325 ± 146.2 million/ml, respectively and the sperm motility, viability and total abnormality was 73.3, 75.2 and 6.2%, respectively at 3 months of age. Taken together, the testosterone level, testicular growth and development and epididymal spermiogram indicate the trait of early sexual maturity in the local pigs as compared to Hampshire. Copyright © 2011 Elsevier Inc. All rights reserved.

Fire management strategies to maintain species population processes in a fragmented landscape of fire-interval extremes.

PubMed

Tulloch, Ayesha I T; Pichancourt, Jean-Baptiste; Gosper, Carl R; Sanders, Angela; Chadès, Iadine

2016-10-01

Changed fire regimes have led to declines of fire-regime-adapted species and loss of biodiversity globally. Fire affects population processes of growth, reproduction, and dispersal in different ways, but there is little guidance about the best fire regime(s) to maintain species population processes in fire-prone ecosystems. We use a process-based approach to determine the best range of fire intervals for keystone plant species in a highly modified Mediterranean ecosystem in southwestern Australia where current fire regimes vary. In highly fragmented areas, fires are few due to limited ignitions and active suppression of wildfire on private land, while in highly connected protected areas fires are frequent and extensive. Using matrix population models, we predict population growth of seven Banksia species under different environmental conditions and patch connectivity, and evaluate the sensitivity of species survival to different fire management strategies and burning intervals. We discover that contrasting, complementary patterns of species life-histories with time since fire result in no single best fire regime. All strategies result in the local patch extinction of at least one species. A small number of burning strategies secure complementary species sets depending on connectivity and post-fire growing conditions. A strategy of no fire always leads to fewer species persisting than prescribed fire or random wildfire, while too-frequent or too-rare burning regimes lead to the possible local extinction of all species. In low landscape connectivity, we find a smaller range of suitable fire intervals, and strategies of prescribed or random burning result in a lower number of species with positive growth rates after 100 years on average compared with burning high connectivity patches. Prescribed fire may reduce or increase extinction risk when applied in combination with wildfire depending on patch connectivity. Poor growing conditions result in a significantly reduced number of species exhibiting positive growth rates after 100 years of management. By exploring the consequences of managing fire, we are able to identify which species are likely to disappear under a given fire regime. Identifying the appropriate complementarity of fire intervals, and their species-specific as well as community-level consequences, is crucial to reduce local extinctions of species in fragmented fire-prone landscapes. © 2016 by the Ecological Society of America.

Empirical Model of the Location of the Main Ionospheric Trough

NASA Astrophysics Data System (ADS)

Deminov, M. G.; Shubin, V. N.

2018-05-01

The empirical model of the location of the main ionospheric trough (MIT) is developed based on an analysis of data from CHAMP satellite measured at the altitudes of 350-450 km during 2000-2007; the model is presented in the form of the analytical dependence of the invariant latitude of the trough minimum Φm on the magnetic local time (MLT), the geomagnetic activity, and the geographical longitude for the Northern and Southern Hemispheres. The time-weighted average index Kp(τ), the coefficient of which τ = 0.6 is determined by the requirement of the model minimum deviation from experimental data, is used as an indicator of geomagnetic activity. The model has no limitations, either in local time or geomagnetic activity. However, the initial set of MIT minima mainly contains data dealing with an interval of 16-08 MLT for Kp(τ) < 6; therefore, the model is rather qualitative outside this interval. It is also established that (a) the use of solar local time (SLT) instead of MLT increases the model error no more than by 5-10%; (b) the amplitude of the longitudinal effect at the latitude of MIT minimum in geomagnetic (invariant) coordinates is ten times lower than that in geographical coordinates.

Education Research: Bias and poor interrater reliability in evaluating the neurology clinical skills examination

PubMed Central

Schuh, L A.; London, Z; Neel, R; Brock, C; Kissela, B M.; Schultz, L; Gelb, D J.

2009-01-01

Objective: The American Board of Psychiatry and Neurology (ABPN) has recently replaced the traditional, centralized oral examination with the locally administered Neurology Clinical Skills Examination (NEX). The ABPN postulated the experience with the NEX would be similar to the Mini-Clinical Evaluation Exercise, a reliable and valid assessment tool. The reliability and validity of the NEX has not been established. Methods: NEX encounters were videotaped at 4 neurology programs. Local faculty and ABPN examiners graded the encounters using 2 different evaluation forms: an ABPN form and one with a contracted rating scale. Some NEX encounters were purposely failed by residents. Cohen’s kappa and intraclass correlation coefficients (ICC) were calculated for local vs ABPN examiners. Results: Ninety-eight videotaped NEX encounters of 32 residents were evaluated by 20 local faculty evaluators and 18 ABPN examiners. The interrater reliability for a determination of pass vs fail for each encounter was poor (kappa 0.32; 95% confidence interval [CI] = 0.11, 0.53). ICC between local faculty and ABPN examiners for each performance rating on the ABPN NEX form was poor to moderate (ICC range 0.14-0.44), and did not improve with the contracted rating form (ICC range 0.09-0.36). ABPN examiners were more likely than local examiners to fail residents. Conclusions: There is poor interrater reliability between local faculty and American Board of Psychiatry and Neurology examiners. A bias was detected for favorable assessment locally, which is concerning for the validity of the examination. Further study is needed to assess whether training can improve interrater reliability and offset bias. GLOSSARY ABIM = American Board of Internal Medicine; ABPN = American Board of Psychiatry and Neurology; CI = confidence interval; HFH = Henry Ford Hospital; ICC = intraclass correlation coefficients; IM = internal medicine; mini-CEX = Mini-Clinical Evaluation Exercise; NEX = Neurology Clinical Skills Examination; RITE = residency inservice training examination; UC = University of Cincinnati; UM = University of Michigan; USF = University of South Florida. PMID:19605769

On the mass of the local group

DOE Office of Scientific and Technical Information (OSTI.GOV)

González, Roberto E.; Kravtsov, Andrey V.; Gnedin, Nickolay Y., E-mail: regonzar@astro.puc.cl

2014-10-01

We use recent proper motion measurements of the tangential velocity of M31, along with its radial velocity and distance, to derive the likelihood of the sum of halo masses of the Milky Way and M31. This is done using a sample of halo pairs in the Bolshoi cosmological simulation of ΛCDM cosmology selected to match the properties and the environment of the Local Group. The resulting likelihood gives an estimate of the sum of the masses of M {sub MW,} {sub 200c} + M {sub M31,} {sub 200c} = 2.40{sub −1.05}{sup +1.95}×10{sup 12} M{sub ⊙} (90% confidence interval). This estimatemore » is consistent with individual mass estimates for the Milky Way and M31 and is consistent, albeit somewhat on the low side, with the mass estimated using the timing argument. We show that although the timing argument is unbiased on average for all pairs, for pairs constrained to have radial and tangential velocities similar to that of the Local Group the argument overestimates the sum of masses by a factor of 1.6. Using similar technique, we estimate the total dark matter mass enclosed within 1 Mpc from the Local Group barycenter to be M{sub LG}(r<1 Mpc)=4.2{sub −2.0}{sup +3.4}×10{sup 12} M{sub ⊙} (90% confidence interval).« less

Measuring levee elevation heights in North Louisiana.

DOT National Transportation Integrated Search

2010-01-01

The primary goals of this research are to measure the elevation and centerline coordinates of the top of federal and local levees and also to ensure that the resulting global positioning system (GPS) measurement data is within a precision interval of...

Shallowing-upward cyclic patterns within larger-scale transgressive-regressive (T-R) sedimentary sequences, St. Peter through Decorah Formations, Ordovician, Iowa area

DOE Office of Scientific and Technical Information (OSTI.GOV)

Witzke, B.J.

1993-03-01

Four large-scale (2--8 Ma) T-R sedimentary sequences of M. Ord. age (late Chaz.-Sherm.) were delimited by Witzke Kolata (1980) in the Iowa area, each bounded by local to regional unconformity/disconformity surfaces. These encompass both siliciclastic and carbonate intervals, in ascending order: (1) St. Peter-Glenwood fms., (2) Platteville Fm., (3) Decorah Fm., (4) Dunleith/upper Decorah fms. Finer-scale resolution of depth-related depositional features has led to regional recognition of smaller-scale shallowing-upward cyclicity contained within each large-scale sequence. Such smaller-scale cyclicity encompasses stratigraphic intervals of 1--10 m thickness, with estimated durations of 0.5--1.5 Ma. The St. Peter Sandst. has long been regarded asmore » a classic transgressive sheet sand. However, four discrete shallowing-upward packages characterize the St. Peter-Glenwood interval regionally (IA, MN, NB, KS), including western facies displaying coarsening-upward sandstone packages with condensed conodont-rich brown shale and phosphatic sediments in their lower part (local oolitic ironstone), commonly above pyritic hardgrounds. Regional continuity of small-scale cyclic patterns in M. Ord. strata of the Iowa area may suggest eustatic controls; this can be tested through inter-regional comparisons.« less

High-dose-rate interstitial brachytherapy for the treatment of high-volume locally recurrent endometrial carcinoma.

PubMed

Huang, Kitty; D'Souza, David; Patil, Nikhilesh; Velker, Vikram; Leung, Eric; Stitt, Larry; Whiston, Frances; Sugimoto, Akira; McGee, Jacob; Prefontaine, Michel

2016-01-01

Limited therapeutic options are available for the treatment of locally recurrent endometrial carcinoma. Our objective was to report an institutional experience using interstitial brachytherapy (IBT) to treat significant recurrent endometrial carcinoma, including previously irradiated disease. Between December 2004 and September 2012, 40 patients with high-volume locally recurrent endometrial cancer were treated by high-dose-rate IBT (± external beam radiation therapy EBRT). Sixteen patients had prior radiotherapy: EBRT alone (n = 5), intracavitary brachytherapy alone (n = 3), or EBRT with intracavitary brachytherapy boost (n = 8). Actuarial outcome rates were calculated using the Kaplan-Meier method and compared using the log-rank test. Median followup interval was 18 months. Median disease-free interval was 61 months. Actuarial local control, progression-free survival (PFS), and overall survival were 74% and 60%, 70% and 51%, and 83% and 72% at 12 and 24 months, respectively. p-Values for local control, progression-free survival, and overall survival between patient who had prior RT (n = 16) to no prior RT (n = 24) were p = 0.38, 0.32, and 0.90, respectively. Acute toxicities include Grade 1-2 pain (5%), genitourinary (7%), gastrointestinal (12%), soft tissue (5%), and dermatologic (12%). Four patients observed late Grade 3-4 toxicities, including rectal bleeding/fistula and soft tissue necrosis. High-dose-rate IBT is an effective treatment for locally recurrent endometrial carcinoma with an acceptable toxicity profile. Outcomes are similar between previously irradiated and nonirradiated patients. In women who have received prior radiotherapy and are often considered for palliative treatment, interstitial brachytherapy is a potentially curative option. Copyright © 2016 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved.

Mammal extinctions, body size, and paleotemperature

USGS Publications Warehouse

Bown, T.M.; Holroyd, P.A.; Rose, K.D.

1994-01-01

There is a general inverse relationship between the natural logarithm of tooth area (a body size indicator) of some fossil mammals and paleotemperature during approximately 2.9 million years of the early Eocene in the Bighorn Basin of northwest Wyoming. When mean temperatures became warmer, tooth areas tended to become smaller. During colder times, larger species predominated; these generally became larger or remained the same size. Paleotemperature trends also markedly affected patterns of local (and, perhaps, regional) extinction and immigration. New species appeared as immigrants during or near the hottest (smaller forms) and coldest (larger forms) intervals. Paleotemperature trend reversals commonly resulted in the ultimate extinction of both small forms (during cooling intervals) and larger forms (during warming intervals). These immigrations and extinctions mark faunal turnovers that were also modulated by sharp increases in sediment accumulation rate.

Use of synthetic sonic logs derived from seismic data in interpretation of stratigraphic variation in cretaceous carbonates of North field area, Qatar

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aves, H.S.; Tappmeyer, D.M.

This study uses geologic and synthetic sonic sections to evaluate the hydrocarbon potential of the Lower and middle Cretaceous Thamama Group carbonates of the Mishrif, Nahr, Umr, Shuaiba, and Kharaib Formations in the North Field, Qatar. The North field area, a regional high throughout Lower and middle Cretaceous time, is document by depositional thinning and by higher energy carbonate facies development. Oil and gas accumulations are found on the crestal portions of this paleohigh in structural/stratigraphic traps. Three factors affect the interval velocities on both a regional and local basis. These are (1) variation of carbonate facies-higher energy wackestone/packstone andmore » possibly grainstones flanked by predominantly mudstones, (2) secondary porosity developed near the top of unconformity surfaces, and (3) the existence of hydrocarbons in the reservoir. Many local lateral and vertical variations in interval velocities were noted on the synthetic sonic sections that would have otherwise been undetected, such as areas of tight or porous reservoir development, permeability barriers, and subtle faulting. In these studied formations, there are many examples of low interval velocity zones that are known to contain hydrocarbons whereas equivalent higher interval velocity zones on the seismic sections at other well site locations do not contain hydrocarbons. In many places, these variations are of sufficient magnitude to be mapped as intraformational permeability barriers. These variations were useful in explaining the occurrence of different oil-water and gas-water contacts within the same formation that could not be explained solely on structural criteria.« less

Pediatric reference value distributions and covariate-stratified reference intervals for 29 endocrine and special chemistry biomarkers on the Beckman Coulter Immunoassay Systems: a CALIPER study of healthy community children.

PubMed

Karbasy, Kimiya; Lin, Danny C C; Stoianov, Alexandra; Chan, Man Khun; Bevilacqua, Victoria; Chen, Yunqi; Adeli, Khosrow

2016-04-01

The CALIPER program is a national research initiative aimed at closing the gaps in pediatric reference intervals. CALIPER previously reported reference intervals for endocrine and special chemistry markers on Abbott immunoassays. We now report new pediatric reference intervals for immunoassays on the Beckman Coulter Immunoassay Systems and assess platform-specific differences in reference values. A total of 711 healthy children and adolescents from birth to <19 years of age were recruited from the community. Serum samples were collected for measurement of 29 biomarkers on the Beckman Coulter Immunoassay Systems. Statistically relevant age and/or gender-based partitions were determined, outliers removed, and reference intervals calculated in accordance with Clinical and Laboratory Standards Institute (CLSI) EP28-A3c guidelines. Complex profiles were observed for all 29 analytes, necessitating unique age and/or sex-specific partitions. Overall, changes in analyte concentrations observed over the course of development were similar to trends previously reported, and are consistent with biochemical and physiological changes that occur during childhood. Marked differences were observed for some assays including progesterone, luteinizing hormone and follicle-stimulating hormone where reference intervals were higher than those reported on Abbott immunoassays and parathyroid hormone where intervals were lower. This study highlights the importance of determining reference intervals specific for each analytical platform. The CALIPER Pediatric Reference Interval database will enable accurate diagnosis and laboratory assessment of children monitored by Beckman Coulter Immunoassay Systems in health care institutions worldwide. These reference intervals must however be validated by individual labs for the local pediatric population as recommended by CLSI.

Clinical chemistry reference intervals of healthy adult populations in Gojjam Zones of Amhara National Regional State, Northwest Ethiopia

PubMed Central

Amuamuta, Asmare; Mulu, Wondemagegn; Yimer, Mulat; Zenebe, Yohannes; Adem, Yesuf; Abera, Bayeh; Gebeyehu, Wondemu; Gebregziabher, Yakob

2017-01-01

Background Reference interval is crucial for disease screening, diagnosis, monitoring, progression and treatment efficacy. Due to lack of locally derived reference values for the parameters, clinicians use reference intervals derived from western population. But, studies conducted in different African countries have indicated differences between locally and western derived reference values. Different studies also indicated considerable variation in clinical chemistry reference intervals by several variables such as age, sex, geographical location, environment, lifestyle and genetic variation. Objective This study aimed to determine the reference intervals of common clinical chemistry parameters of the community of Gojjam Zones, Northwest Ethiopia. Method Population based cross-sectional study was conducted from November 2015 to December 2016 in healthy adult populations of Gojjam zone. Data such as, medical history, physical examination and socio-demographic data were collected. In addition, laboratory investigations were undertaken to screen the population. Clinical chemistry parameters were measured using Mindray BS 200 clinical chemistry autoanalyzer as per the manufacturer’s instructions. Descriptive statistics was used to calculate mean, median and 95th percentiles. Independent sample T-test and one way ANOVA were used to see association between variables. Results After careful screening of a total of 799 apparently healthy adults who were consented for this study, complete data from 446 (224 females and 222 males) were included for the analysis. The mean age of both the study participants was 28.8 years. Males had high (P<0.05) mean and 2.5th-97.5th percentile ranges of ALT, AST, ALP, creatinine and direct bilirubin. The reference intervals of amylase, LDH, total protein and total bilirubin were not significantly different between the two sex groups (P>0.05). Mean, median, 95% percentile values of AST, ALP, amylase, LDH, creatinine, total protein, total bilirubin, and direct bilirubin across all age groups of participants were similar (P>0.05). But, there was a significant difference in the value of ALT (P<0.05). The reference intervals of ALT, total protein and creatinine were significantly (P<0.05) high in people having monthly income >1500 ETB compared to those with low monthly income. Significant (P<0.05) higher values of the ALT, ALP and total protein were observed in people living in high land compared to low land residences. Conclusion The study showed that some of the common clinical chemistry parameters reference intervals of healthy adults in Gojjam zones were higher than the reference intervals generated from developed countries. Therefore, strict adherence to the reference values generated in developed countries could lead to inappropriate diagnosis and treatment of patients. There was also variation of reference interval values based on climate, gender, age, monthly income and geographical locations. Therefore, further study is required to establish reference intervals for Ethiopian population. PMID:28886191

Environmental Controls on Photosynthetic Microbial Mat Distribution and Morphogenesis on a 3.42 Ga Clastic-Starved Platform

NASA Astrophysics Data System (ADS)

Tice, Michael M.

2009-12-01

All mats are preserved in the shallowest-water interval of those rocks deposited below normal wave base and above storm wave base. This interval is bounded below by a transgressive lag formed during regional flooding and above by a small condensed section that marks a local relative sea-level maximum. Restriction of all mat morphotypes to the shallowest interval of the storm-active layer in the BRC ocean reinforces previous interpretations that these mats were constructed primarily by photosynthetic organisms. Morphotypes α and β dominate the lower half of this interval and grew during deposition of relatively coarse detrital carbonaceous grains, while morphotype γ dominates the upper half and grew during deposition of fine detrital carbonaceous grains. The observed mat distribution suggests that either light intensity or, more likely, small variations in ambient current energy acted as a first-order control on mat morphotype distribution. These results demonstrate significant environmental control on biological morphogenetic processes independent of influences from siliciclastic sedimentation.

Case-control study on the association between a cluster of childhood haematopoietic malignancies and local environmental factors in Aalsmeer, The Netherlands.

PubMed Central

Mulder, Y M; Drijver, M; Kreis, I A

1994-01-01

STUDY OBJECTIVE AND DESIGN--In Aalsmeer, a horticultural community near the main international airport in The Netherlands, a more than fourfold increase in the incidence of haematopoietic malignancies in young people was observed between 1980 and 1985. In a population based case-control study, the association with local environmental factors was investigated. PARTICIPANTS--For each patient younger than 40 years of age (n = 14) diagnosed between 1975 and 1989, four age and sex matched controls were selected via local general practitioners. METHODS--All parents of patients and controls completed a questionnaire on their lifestyle, living conditions, and health, for several years preceding each individual diagnosis. Odds ratios (ORs) with 95% confidence intervals (CI) were calculated, matched, and, if necessary, stratified for neighbourhood. MAIN RESULTS--Increased ORs were recorded for intensive use of petroleum products and pesticides by the patients themselves and their fathers: OR petroleum products: 8.0 (95% CI 2.2, 129.9) and 9.0 (1.0, 66.1) respectively; OR pesticides: 6.0 (0.6, 49.3) and 3.2 (1.0, 10.1) respectively. Swimming in a local pond was also significantly associated with the disease: OR = 5.3 (1.3, 17.4). In the 1970s this pond had been polluted by petroleum products and pesticides. CONCLUSIONS--The increased incidence of childhood haematopoietic malignancies in Aalsmeer may have been associated with several specific local environmental factors. Interpretation of the results, however, should take into account the fact that confidence intervals were wide because of the limited number of cases. PMID:8189171

Predictors and Patterns of Local, Regional, and Distant Failure in Squamous Cell Carcinoma of the Vulva.

PubMed

Bogani, Giorgio; Cromi, Antonella; Serati, Maurizio; Uccella, Stefano; Donato, Violante Di; Casarin, Jvan; Naro, Edoardo Di; Ghezzi, Fabio

2017-06-01

To identify factors predicting for recurrence in vulvar cancer patients undergoing surgical treatment. We retrospectively evaluated data of consecutive patients with squamous cell vulvar cancer treated between January 1, 1990 and December 31, 2013. Basic descriptive statistics and multivariable analysis were used to design predicting models influencing outcomes. Five-year disease-free survival (DFS) and overall survival (OS) were analyzed using the Cox model. The study included 101 patients affected by vulvar cancer: 64 (63%) stage I, 12 (12%) stage II, 20 (20%) stage III, and 5 (5%) stage IV. After a mean (SD) follow-up of 37.6 (22.1) months, 21 (21%) recurrences occurred. Local, regional, and distant failures were recorded in 14 (14%), 6 (6%), and 3 (3%) patients, respectively. Five-year DFS and OS were 77% and 82%, respectively. At multivariate analysis only stromal invasion >2 mm (hazard ratio: 4.9 [95% confidence interval, 1.17-21.1]; P=0.04) and extracapsular lymph node involvement (hazard ratio: 9.0 (95% confidence interval, 1.17-69.5); P=0.03) correlated with worse DFS, although no factor independently correlated with OS. Looking at factors influencing local and regional failure, we observed that stromal invasion >2 mm was the only factor predicting for local recurrence, whereas lymph node extracapsular involvement predicted for regional recurrence. Stromal invasion >2 mm and lymph node extracapsular spread are the most important factors predicting for local and regional failure, respectively. Studies evaluating the effectiveness of adjuvant treatment in high-risk patients are warranted.

Automated Interval velocity picking for Atlantic Multi-Channel Seismic Data

NASA Astrophysics Data System (ADS)

Singh, Vishwajit

2016-04-01

This paper described the challenge in developing and testing a fully automated routine for measuring interval velocities from multi-channel seismic data. Various approaches are employed for generating an interactive algorithm picking interval velocity for continuous 1000-5000 normal moveout (NMO) corrected gather and replacing the interpreter's effort for manual picking the coherent reflections. The detailed steps and pitfalls for picking the interval velocities from seismic reflection time measurements are describe in these approaches. Key ingredients these approaches utilized for velocity analysis stage are semblance grid and starting model of interval velocity. Basin-Hopping optimization is employed for convergence of the misfit function toward local minima. SLiding-Overlapping Window (SLOW) algorithm are designed to mitigate the non-linearity and ill- possessedness of root-mean-square velocity. Synthetic data case studies addresses the performance of the velocity picker generating models perfectly fitting the semblance peaks. A similar linear relationship between average depth and reflection time for synthetic model and estimated models proposed picked interval velocities as the starting model for the full waveform inversion to project more accurate velocity structure of the subsurface. The challenges can be categorized as (1) building accurate starting model for projecting more accurate velocity structure of the subsurface, (2) improving the computational cost of algorithm by pre-calculating semblance grid to make auto picking more feasible.

Cluster analysis based on dimensional information with applications to feature selection and classification

NASA Technical Reports Server (NTRS)

Eigen, D. J.; Fromm, F. R.; Northouse, R. A.

1974-01-01

A new clustering algorithm is presented that is based on dimensional information. The algorithm includes an inherent feature selection criterion, which is discussed. Further, a heuristic method for choosing the proper number of intervals for a frequency distribution histogram, a feature necessary for the algorithm, is presented. The algorithm, although usable as a stand-alone clustering technique, is then utilized as a global approximator. Local clustering techniques and configuration of a global-local scheme are discussed, and finally the complete global-local and feature selector configuration is shown in application to a real-time adaptive classification scheme for the analysis of remote sensed multispectral scanner data.

Practice Patterns and Outcomes for Pemetrexed Plus Platinum Doublet as Neoadjuvant Chemotherapy in Adenocarcinomas of Lung: Looking Beyond the Usual Paradigm.

PubMed

Noronha, V; Zanwar, S; Joshi, A; Patil, V M; Mahajan, A; Janu, A; Agarwal, J P; Bhargava, P; Kapoor, A; Prabhash, K

2018-01-01

Neoadjuvant chemotherapy (NACT) is the standard of care in non-small cell lung cancers (NSCLC) with locally advanced N2 disease. There is a scarcity of data for the pemetrexed-platinum regimen as NACT. Also, apart from N2 disease, the role of NACT in locally advanced NSCLCs for tumour downstaging is unclear. Non-metastatic adenocarcinomas of lung treated with pemetrexed-platinum-based NACT were analysed. The patients with locoregionally advanced N2 disease and those who were borderline candidates for upfront definitive treatment were planned for NACT after discussion in a multidisciplinary clinic. In total, four cycles of 3-weekly pemetrexed and platinum were delivered in the combined neoadjuvant and adjuvant setting. A response assessment was carried out using RECIST criteria. Progression-free (PFS) and overall survival were calculated using the Kaplan-Meier method. Of 114 patients, 96 evaluable patients received NACT with pemetrexed-platinum. The most common indication for NACT was N2 disease at baseline (46.8%). The objective response rate was 36.4% (95% confidence interval 22-52%), including two complete and 32 partial responses, whereas 12.5% of patients had progressive disease on NACT. The median PFS was 14 months (95% confidence interval 10.7-17.3) and the median overall survival was 22 months (95% confidence interval 15.6-28.4) at a median follow-up of 16 months. There was a significant improvement in the overall survival of patients undergoing definitive therapy versus no definitive therapy (median overall survival 25 months [95% confidence interval 19.6-30.4] versus 12 months [95% confidence interval 3.2-20.7], respectively; P = 0.015, hazard ratio 0.56 [95% confidence interval 0.3-0.9]). Among patients who could not undergo definitive chemoradiation upfront due to dosimetric constraints (n = 34), 24 (70.6%) patients finally underwent definitive therapy after NACT. Pemetrexed-platinum-based NACT seems to be an effective option and many borderline cases, where upfront definitive therapy is not feasible, may become amenable to the same after incorporation of NACT. Copyright © 2017 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.

Joint Command Decision Support 21st Century Technology Demonstration: Human Factors Style Guide

DTIC Science & Technology

2009-03-01

education, religion , etc.) or for a variable sampled at discrete intervals. Histograms (bar charts without spaces between the bars) shall be used when...with Zulu time as the default. The seconds are optional. All colons are required and the Zulu (Z) shall be capitalized. 3. The display shall...include Zulu time and local time; Zulu time shall be presented above local time. 4. The date time group shall be presented on the COMDAT status bar on the

Impacts of Sigma Coordinates on the Euler and Navier-Stokes Equations using Continuous Galerkin Methods

DTIC Science & Technology

2009-03-01

the 1- D local basis functions. The 1-D Lagrange polynomial local basis function, using Legendre -Gauss-Lobatto interpolation points, was defined by...cases were run using 10th order polynomials , with contours from -0.05 to 0.525 K with an interval of 0.025 K...after 700 s for reso- lutions: (a) 20, (b) 10, and (c) 5 m. All cases were run using 10th order polynomials , with contours from -0.05 to 0.525 K

The Sooner the Better? How Symptom Interval Correlates With Outcome in Children and Adolescents With Solid Tumors: Regression Tree Analysis of the Findings of a Prospective Study.

PubMed

Ferrari, Andrea; Lo Vullo, Salvatore; Giardiello, Daniele; Veneroni, Laura; Magni, Chiara; Clerici, Carlo Alfredo; Chiaravalli, Stefano; Casanova, Michela; Luksch, Roberto; Terenziani, Monica; Spreafico, Filippo; Meazza, Cristina; Catania, Serena; Schiavello, Elisabetta; Biassoni, Veronica; Podda, Marta; Bergamaschi, Luca; Puma, Nadia; Massimino, Maura; Mariani, Luigi

2016-03-01

The potential impact of diagnostic delays on patients' outcomes is a debated issue in pediatric oncology and discordant results have been published so far. We attempted to tackle this issue by analyzing a prospective series of 351 consecutive children and adolescents with solid malignancies using innovative statistical tools. To address the nonlinear complexity of the association between symptom interval and overall survival (OS), a regression tree algorithm was constructed with sequential binary splitting rules and used to identify homogeneous patient groups vis-à-vis functional relationship between diagnostic delay and OS. Three different groups were identified: group A, with localized disease and good prognosis (5-year OS 85.4%); group B, with locally or regionally advanced, or metastatic disease and intermediate prognosis (5-year OS 72.9%), including neuroblastoma, Wilms tumor, non-rhabdomyosarcoma soft tissue sarcoma, and germ cell tumor; and group C, with locally or regionally advanced, or metastatic disease and poor prognosis (5-year OS 45%), including brain tumors, rhabdomyosarcoma, and bone sarcoma. The functional relationship between symptom interval and mortality risk differed between the three subgroups, there being no association in group A (hazard ratio [HR]: 0.96), a positive linear association in group B (HR: 1.48), and a negative linear association in group C (HR: 0.61). Our analysis suggests that at least a subset of patients can benefit from an earlier diagnosis in terms of survival. For others, intrinsic aggressiveness may mask the potential effect of diagnostic delays. Based on these findings, early diagnosis should remain a goal for pediatric cancer patients. © 2015 Wiley Periodicals, Inc.

Forensic Entomology: Evaluating Uncertainty Associated With Postmortem Interval (PMI) Estimates With Ecological Models.

PubMed

Faris, A M; Wang, H-H; Tarone, A M; Grant, W E

2016-05-31

Estimates of insect age can be informative in death investigations and, when certain assumptions are met, can be useful for estimating the postmortem interval (PMI). Currently, the accuracy and precision of PMI estimates is unknown, as error can arise from sources of variation such as measurement error, environmental variation, or genetic variation. Ecological models are an abstract, mathematical representation of an ecological system that can make predictions about the dynamics of the real system. To quantify the variation associated with the pre-appearance interval (PAI), we developed an ecological model that simulates the colonization of vertebrate remains by Cochliomyia macellaria (Fabricius) (Diptera: Calliphoridae), a primary colonizer in the southern United States. The model is based on a development data set derived from a local population and represents the uncertainty in local temperature variability to address PMI estimates at local sites. After a PMI estimate is calculated for each individual, the model calculates the maximum, minimum, and mean PMI, as well as the range and standard deviation for stadia collected. The model framework presented here is one manner by which errors in PMI estimates can be addressed in court when no empirical data are available for the parameter of interest. We show that PAI is a potential important source of error and that an ecological model is one way to evaluate its impact. Such models can be re-parameterized with any development data set, PAI function, temperature regime, assumption of interest, etc., to estimate PMI and quantify uncertainty that arises from specific prediction systems. © The Authors 2016. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Insights into the Cell Shape Dynamics of Migrating Dictyostelium discoideum

NASA Astrophysics Data System (ADS)

Driscoll, Meghan; Homan, Tess; McCann, Colin; Parent, Carole; Fourkas, John; Losert, Wolfgang

2010-03-01

Dynamic cell shape is a highly visible manifestation of the interaction between the internal biochemical state of a cell and its external environment. We analyzed the dynamic cell shape of migrating cells using the model system Dictyostelium discoideum. Applying a snake algorithm to experimental movies, we extracted cell boundaries in each frame and followed local boundary motion over long time intervals. Using a local motion measure that corresponds to protrusive/retractive activity, we found that protrusions are intermittent and zig-zag, whereas retractions are more sustained and straight. Correlations of this local motion measure reveal that protrusions appear more localized than retractions. Using a local shape measure, curvature, we also found that small peaks in boundary curvature tend to originate at the front of cells and propagate backwards. We will review the possible cytoskeletal origin of these mechanical waves.

Variability of ionospheric TEC during solar and geomagnetic minima (2008 and 2009): external high speed stream drivers

NASA Astrophysics Data System (ADS)

Verkhoglyadova, O. P.; Tsurutani, B. T.; Mannucci, A. J.; Mlynczak, M. G.; Hunt, L. A.; Runge, T.

2013-02-01

We study solar wind-ionosphere coupling through the late declining phase/solar minimum and geomagnetic minimum phases during the last solar cycle (SC23) - 2008 and 2009. This interval was characterized by sequences of high-speed solar wind streams (HSSs). The concomitant geomagnetic response was moderate geomagnetic storms and high-intensity, long-duration continuous auroral activity (HILDCAA) events. The JPL Global Ionospheric Map (GIM) software and the GPS total electron content (TEC) database were used to calculate the vertical TEC (VTEC) and estimate daily averaged values in separate latitude and local time ranges. Our results show distinct low- and mid-latitude VTEC responses to HSSs during this interval, with the low-latitude daytime daily averaged values increasing by up to 33 TECU (annual average of ~20 TECU) near local noon (12:00 to 14:00 LT) in 2008. In 2009 during the minimum geomagnetic activity (MGA) interval, the response to HSSs was a maximum of ~30 TECU increases with a slightly lower average value than in 2008. There was a weak nighttime ionospheric response to the HSSs. A well-studied solar cycle declining phase interval, 10-22 October 2003, was analyzed for comparative purposes, with daytime low-latitude VTEC peak values of up to ~58 TECU (event average of ~55 TECU). The ionospheric VTEC changes during 2008-2009 were similar but ~60% less intense on average. There is an evidence of correlations of filtered daily averaged VTEC data with Ap index and solar wind speed. We use the infrared NO and CO2 emission data obtained with SABER on TIMED as a proxy for the radiation balance of the thermosphere. It is shown that infrared emissions increase during HSS events possibly due to increased energy input into the auroral region associated with HILDCAAs. The 2008-2009 HSS intervals were ~85% less intense than the 2003 early declining phase event, with annual averages of daily infrared NO emission power of ~ 3.3 × 1010 W and 2.7 × 1010 W in 2008 and 2009, respectively. The roles of disturbance dynamos caused by high-latitude winds (due to particle precipitation and Joule heating in the auroral zones) and of prompt penetrating electric fields (PPEFs) in the solar wind-ionosphere coupling during these intervals are discussed. A correlation between geoeffective interplanetary electric field components and HSS intervals is shown. Both PPEF and disturbance dynamo mechanisms could play important roles in solar wind-ionosphere coupling during prolonged (up to days) external driving within HILDCAA intervals.

Measuring levee elevation heights in North Louisiana.

DOT National Transportation Integrated Search

2009-12-01

The primary goals of this research are to measure the elevation and centerline coordinates of the top of federal and local levees and to ensure that resulting GPS measurement data are within a precise interval of plus or minus 3/10ths of a foot verti...

LOCAL EM ESTIMATION OF THE HAZARD FUNCTION FOR INTERVAL CENSORED DATA. (R824757)

EPA Science Inventory

The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Concl...

Detection of sedimentary structural elements using formation micro imager technique, a case study from South Mansoura-1 well, Nile Delta, Egypt

NASA Astrophysics Data System (ADS)

Abd El-Wahed, Ahmed G.; Anan, Tarek I.

2016-12-01

A detailed structure and sedimentology interpretation was performed for the South Mansoura-1 well. The Formation Micro Imager (FMI) is recorded and interpreted over the interval 9100-8009 ft. This interval belongs to Sidi Salem and Qawasim Formations. Based on azimuth trend of manually picked dips (bed boundaries), the interval can be divided into 4 structural dip zones (Zone 1 (9100-8800 ft), variable azimuth direction with the major trends mainly to SW&NE; Zone 2 (8800-8570 ft), bedding dip azimuth is mainly to the NW; Zone 3 (8570-8250 ft), bedding dip azimuth is mainly to the NE; and Zone 4 (8250-8009 ft), bedding dip azimuth is mainly to the NW). Lamination identified over the interval shows a dominant dip azimuth trend toward North North-West direction. The interbedded shale units are highly laminated and show little evidence of bioturbation. Sand exhibits abundant cross bedding showing a dominant dip azimuth trends toward NNE and NE and more locally to the E. Sixteen truncations identified over the interval show variable azimuth trend with the major trend mainly to the North North-West.

Population-based pediatric reference intervals for general clinical chemistry analytes on the Abbott Architect ci8200 instrument.

PubMed

Ridefelt, Peter; Aldrimer, Mattias; Rödöö, Per-Olof; Niklasson, Frank; Jansson, Leif; Gustafsson, Jan; Hellberg, Dan

2012-02-29

Reference intervals are crucial decision-making tools aiding clinicians in differentiating between healthy and diseased populations. However, for children such values often are lacking or incomplete. Blood samples were obtained from 692 healthy children, aged 6 months to 18 years, recruited in daycare centers and schools. Twelve common general clinical chemistry analytes were measured on the Abbott Architect ci8200 platform; sodium, potassium, chloride, calcium, albumin-adjusted calcium, phosphate, magnesium, creatinine (Jaffe and enzymatic), cystatin C, urea and uric acid. Age- and gender specific pediatric reference intervals were defined by calculating the 2.5th and 97.5th percentiles. The data generated is primarily applicable to a Caucasian population when using the Abbott Architect platform, but could be used by any laboratory if validated for the local patient population.

On-line registration of femtosecond time intervals based on polarization properties of femtosecond stimulated photon echo generated on exciton states

NASA Astrophysics Data System (ADS)

Bakhodurov, A. U.; Vashourin, N. S.; Vinogradov, E. A.; Gazizov, K. Sh.; Kompanets, V. O.; Popov, I. I.; Putilin, S. E.; Chekalin, S. V.

2017-10-01

This paper reflects the results of the research on the character of the dependence of the non-Faraday rotation of the femtosecond stimulated photon echo polarization plane on the time interval between the second and third exciting pulses, discretely varying from 180 to 900 fs in increments 180 fs. The time interval between the first and second pulses was equal to zero. The echo signal was formed at room temperature on exciton states localized on the surface defects of a thin three-layer textured ZnO/Si(P)/Si(B) film in the presence of a homogeneous magnetic field of 0.25 mT applied longitudinally to the optical excitation axis. The qualitative coincidence of the investigated dependence with the theoretical prediction of the investigated effect for gaseous medium is shown.

Periapical Microsurgery: The Effects of Locally Injected Dexamethasone on Pain, Swelling, Bruising, and Wound Healing.

PubMed

Kan, Elena; Coelho, Marcelo Santos; Reside, Jonathan; Card, Steven J; Tawil, Peter Z

2016-11-01

The purpose of this prospective, double-blind, randomized clinical trial was to evaluate the postoperative healing of endodontic periapical microsurgery after local administration of dexamethasone. Sixty patients were divided into 2 groups. The dexamethasone group received a single local submucosal injection of 4 mg dexamethasone, and the placebo group received a submucosal injection of saline solution at the conclusion of standardized periapical microsurgery. Acetaminophen and hydrocodone/acetaminophen were prescribed for pain relief. A Likert-like 6-point scale was used for self-evaluation of pain, bruising, swelling, and wound healing at 24, 48, 72, 96 hours and at 1 week. The number of tablets taken was registered. Data were analyzed using the chi-square and Fisher exact tests at a significance level of P < .05. No improvements in pain, bruising, and wound healing were registered at any time interval. No difference was found in the number of tablets taken for pain relief. Subjects who received the dexamethasone injection reported less swelling 24 hours after periapical microsurgery (P < .05) but showed no significant benefit for the longer follow-up periods. This study shows that a 4-mg dose of dexamethasone administered through a local submucosal injection after periapical microsurgery has minimal impact on pain, bruising, and apparent wound healing at any time over a 7-day interval, and the impact on swelling seems limited. Copyright © 2016 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.

Receptive amusia: evidence for cross-hemispheric neural networks underlying music processing strategies.

PubMed

Schuppert, M; Münte, T F; Wieringa, B M; Altenmüller, E

2000-03-01

Perceptual musical functions were investigated in patients suffering from unilateral cerebrovascular cortical lesions. Using MIDI (Musical Instrument Digital Interface) technique, a standardized short test battery was established that covers local (analytical) as well as global perceptual mechanisms. These represent the principal cognitive strategies in melodic and temporal musical information processing (local, interval and rhythm; global, contour and metre). Of the participating brain-damaged patients, a total of 69% presented with post-lesional impairments in music perception. Left-hemisphere-damaged patients showed significant deficits in the discrimination of local as well as global structures in both melodic and temporal information processing. Right-hemisphere-damaged patients also revealed an overall impairment of music perception, reaching significance in the temporal conditions. Detailed analysis outlined a hierarchical organization, with an initial right-hemisphere recognition of contour and metre followed by identification of interval and rhythm via left-hemisphere subsystems. Patterns of dissociated and associated melodic and temporal deficits indicate autonomous, yet partially integrated neural subsystems underlying the processing of melodic and temporal stimuli. In conclusion, these data contradict a strong hemispheric specificity for music perception, but indicate cross-hemisphere, fragmented neural substrates underlying local and global musical information processing in the melodic and temporal dimensions. Due to the diverse profiles of neuropsychological deficits revealed in earlier investigations as well as in this study, individual aspects of musicality and musical behaviour very likely contribute to the definite formation of these widely distributed neural networks.

Estimating bridge scour in New York from historical U.S. geological survey streamflow measurements

USGS Publications Warehouse

Butch, Gerard K.; ,

1993-01-01

Historical streamflow measurements by the U.S. Geological Survey an bridge-inspection reports by the New York State Department of Transportation are being used to estimate scour at 31 bridges in New York State. Streamflow measurements that were made before, during, or after high flows are used to estimate scour and to define hydraulic properties associated with floods. Clear-water scour is common at most sites; local scour holes that formed during high flows did not refill after subsequent high flows. The 31 streambeds are armored by gravel; median particle size ranges form 22 to 68 millimeters. Streambed elevations measured after a high flow are assumed to represent the elevations during peak flow. Measurements at several bridges indicate scour by multiple high flows, severe floods, and debris. Three high flows at State Route 23 over the Otselic River in Cortland County produced 6.1 feet of local scour and partly exposed concrete pilings below the footing. Although the recurrence interval of each flow was less than 10 years, a 30-degree angle between the flow and the pier increased the tendency of the streambed to scour. State Route 427 over the Chemung River in Chemung County survived the 1972 flood ( recurrence interval greater than 100 years) because pilings supported the undermined piers. The maximum local scour during the 1972 flood was estimated to be 5.4 feet. A local-scour hole, 2.4 feet deep before the flood, was deepened to 7.8 feet.

KSC-2009-2028

NASA Image and Video Library

2009-03-14

CAPE CANAVERAL, Fla. – Bathed in light on Launch Pad 39A at NASA's Kennedy Space Center in Florida, space shuttle Discovery is revealed after the rotating service structure has been rolled back. The rollback is in preparation for Discovery's liftoff on the STS-119 mission with a crew of seven. An earlier launch attempt March 11 was scrubbed at 2:36 p.m. due to a gaseous hydrogen leak from the external tank at the Ground Umbilical Carrier Plate during tanking. A seven-inch quick disconnect and two seals were replaced. The STS-119 mission is the 28th to the International Space Station and the 125th space shuttle flight. Discovery will deliver the final pair of power-generating solar array wings and the S6 truss segment. Installation of S6 will signal the station's readiness to house a six-member crew for conducting increased science. Liftoff of Discovery is scheduled for 7:43 p.m. EDT on March 15. Photo credit: NASA/Jack Pfaller

STS-99 RSS rollback from Space Shuttle Endeavour on Launch Pad 39A

NASA Technical Reports Server (NTRS)

2000-01-01

Just after sundown, the Rotating Service Structure is rolled back to reveal Space Shuttle Endeavour, mated with its solid rocket boosters (left and right) and external tank (center), poised for launch on mission STS-99. Known as the Shuttle Radar Topography Mission (SRTM), STS-99 is scheduled to lift off 12:47 p.m. EST from Launch Pad 39A. The SRTM will chart a new course to produce unrivaled 3-D images of the Earth's surface, using two antennae and a 200-foot-long section of space station-derived mast protruding from the payload bay. The result of the Shuttle Radar Topography Mission could be close to 1 trillion measurements of the Earth's topography. Besides contributing to the production of better maps, these measurements could lead to improved water drainage modeling, more realistic flight simulators, better locations for cell phone towers, and enhanced navigation safety. The mission is expected to last about 11days, with Endeavour landing at KSC Friday, Feb. 11, at 4:55 p.m. EST.

Expanding role for autonomy in military space

NASA Technical Reports Server (NTRS)

Evans, D. D.; Gajewski, R. R.

1985-01-01

The Jet Propulsion Laboratory is currently transferring satellite on-board autonomy technology to the USAF for use in military spacecraft as a means of lowering the ground support requirements. The techniques were proven on the Viking and Voyager spacecraft and permitted on-board fault detection and correction. New military satellites will incorporate an autonomous redundancy and maintenance management subsystem in an on-board computer, while the system will still be subject to ground-based safing commands for situations demanding deeper analyses. A level 5 autonomy will need 256 kb memory, 10 Mb nonvolatile data storage and 50 W power and will weigh 20 kg. Systems will be periodically checked and compared with an ideal in the data base. Deviations detected will result in a rollback and redundant examination by two microprocessors, which can initiate correction commands until operational criteria are met. The development of the expert systems to the point that they satisfy military specifications is expected to take 10 yr.

KSC-2014-3106

NASA Image and Video Library

2014-07-01

VANDENBERG AIR FORCE BASE, Calif. – NASA's Orbiting Carbon Observatory-2, or OCO-2, stands ready for launch aboard a United Launch Alliance Delta II rocket following rollback of the mobile service tower on Space Launch Complex 2 on Vandenberg Air Force Base in California. Launch of OCO-2 is scheduled for 5:56 a.m. EDT on July 2 following the repair of the pad's water suppression system, which failed on the first launch attempt July 1. OCO-2 is NASA’s first mission dedicated to studying atmospheric carbon dioxide, the leading human-produced greenhouse gas driving changes in Earth’s climate. OCO-2 will provide a new tool for understanding the human and natural sources of carbon dioxide emissions and the natural "sinks" that absorb carbon dioxide and help control its buildup. The observatory will measure the global geographic distribution of these sources and sinks and study their changes over time. To learn more about OCO-2, visit http://www.nasa.gov/oco2. Photo credit: NASA/Randy Beaudoin

KSC-2014-3099

NASA Image and Video Library

2014-07-01

VANDENBERG AIR FORCE BASE, Calif. – At Vandenberg Air Force Base in California, the United Launch Alliance Delta II rocket carrying NASA's Orbiting Carbon Observatory-2, or OCO-2, awaits loading of its cryogenic propellants following rollback of the mobile service tower on Space Launch Complex 2. Launch of OCO-2 is scheduled for 5:56 a.m. EDT on July 2 following the repair of the pad's water suppression system, which failed on the first launch attempt July 1. OCO-2 is NASA’s first mission dedicated to studying atmospheric carbon dioxide, the leading human-produced greenhouse gas driving changes in Earth’s climate. OCO-2 will provide a new tool for understanding the human and natural sources of carbon dioxide emissions and the natural "sinks" that absorb carbon dioxide and help control its buildup. The observatory will measure the global geographic distribution of these sources and sinks and study their changes over time. To learn more about OCO-2, visit http://www.nasa.gov/oco2. Photo credit: NASA/Kim Shiflett

KSC-2014-3097

NASA Image and Video Library

2014-07-01

VANDENBERG AIR FORCE BASE, Calif. – Final preparations are underway for the launch of NASA's Orbiting Carbon Observatory-2, or OCO-2, aboard a United Launch Alliance Delta II rocket, following rollback of the mobile service tower on Space Launch Complex 2 on Vandenberg Air Force Base in California. Launch of OCO-2 is scheduled for 5:56 a.m. EDT on July 2 following the repair of the pad's water suppression system, which failed on the first launch attempt July 1. OCO-2 is NASA’s first mission dedicated to studying atmospheric carbon dioxide, the leading human-produced greenhouse gas driving changes in Earth’s climate. OCO-2 will provide a new tool for understanding the human and natural sources of carbon dioxide emissions and the natural "sinks" that absorb carbon dioxide and help control its buildup. The observatory will measure the global geographic distribution of these sources and sinks and study their changes over time. To learn more about OCO-2, visit http://www.nasa.gov/oco2. Photo credit: NASA/Kim Shiflett

KSC-2014-3095

NASA Image and Video Library

2014-07-01

VANDENBERG AIR FORCE BASE, Calif. – NASA's Orbiting Carbon Observatory-2, or OCO-2, stands ready for launch aboard a United Launch Alliance Delta II rocket following rollback of the mobile service tower on Space Launch Complex 2 on Vandenberg Air Force Base in California. Launch of OCO-2 is scheduled for 5:56 a.m. EDT on July 2 following the repair of the pad's water suppression system, which failed on the first launch attempt July 1. OCO-2 is NASA’s first mission dedicated to studying atmospheric carbon dioxide, the leading human-produced greenhouse gas driving changes in Earth’s climate. OCO-2 will provide a new tool for understanding the human and natural sources of carbon dioxide emissions and the natural "sinks" that absorb carbon dioxide and help control its buildup. The observatory will measure the global geographic distribution of these sources and sinks and study their changes over time. To learn more about OCO-2, visit http://www.nasa.gov/oco2. Photo credit: NASA/Kim Shiflett

KSC-2010-5933

NASA Image and Video Library

2010-12-22

CAPE CANAVERAL, Fla. -- Space shuttle Discovery enters the Vehicle Assembly Building at NASA's Kennedy Space Center in Florida. The 3.4-mile trek, called rollback, from Launch Pad 39A began at 10:48 p.m. yesterday and took about eight hours. Next, Discovery's external fuel tank will be examined and foam reapplied where 89 sensors were installed on the tank's aluminum skin for an instrumented tanking test on Dec. 17. The sensors were used to measure changes in the tank as super-cold propellants were pumped in and drained out. Data and analysis from the test will be used to determine what caused the tops of two, 21-foot-long support beams, called stringers, on the outside of the intertank to crack during fueling on Nov. 5. Discovery's next launch opportunity to the International Space Station on the STS-133 mission is no earlier than Feb. 3, 2011. For more information on STS-133, visit www.nasa.gov/mission_pages/shuttle/shuttlemissions/sts133/. Photo credit: NASA/Frank Michaux

KSC-2010-5932

NASA Image and Video Library

2010-12-22

CAPE CANAVERAL, Fla. -- The bright lights inside the Vehicle Assembly Building at NASA's Kennedy Space Center in Florida invite space shuttle Discovery inside. The 3.4-mile trek, called rollback, from Launch Pad 39A began at 10:48 p.m. yesterday and took about eight hours. Next, Discovery's external fuel tank will be examined and foam reapplied where 89 sensors were installed on the tank's aluminum skin for an instrumented tanking test on Dec. 17. The sensors were used to measure changes in the tank as super-cold propellants were pumped in and drained out. Data and analysis from the test will be used to determine what caused the tops of two, 21-foot-long support beams, called stringers, on the outside of the intertank to crack during fueling on Nov. 5. Discovery's next launch opportunity to the International Space Station on the STS-133 mission is no earlier than Feb. 3, 2011. For more information on STS-133, visit www.nasa.gov/mission_pages/shuttle/shuttlemissions/sts133/. Photo credit: NASA/Frank Michaux

KSC-2010-5927

NASA Image and Video Library

2010-12-21

CAPE CANAVERAL, Fla. -- Space shuttle Discovery, secured to a crawler-transporter, slowly moves away from Launch Pad 39A at NASA's Kennedy Space Center in Florida. The 3.4-mile trek, called rollback, to the Vehicle Assembly Building began at 10:48 p.m. and took about eight hours. Next, Discovery's external fuel tank will be examined and foam reapplied where 89 sensors were installed on the tank's aluminum skin for an instrumented tanking test on Dec. 17. The sensors were used to measure changes in the tank as super-cold propellants were pumped in and drained out. Data and analysis from the test will be used to determine what caused the tops of two, 21-foot-long support beams, called stringers, on the outside of the intertank to crack during fueling on Nov. 5. Discovery's next launch opportunity to the International Space Station on the STS-133 mission is no earlier than Feb. 3, 2011. For more information on STS-133, visit www.nasa.gov/mission_pages/shuttle/shuttlemissions/sts133/. Photo credit: NASA/Frank Michaux

KSC-2010-5925

NASA Image and Video Library

2010-12-21

CAPE CANAVERAL, Fla. -- Space shuttle Discovery, secured to a crawler-transporter, slowly moves away from Launch Pad 39A at NASA's Kennedy Space Center in Florida. The 3.4-mile trek, called rollback, to the Vehicle Assembly Building began at 10:48 p.m. and took about eight hours. Next, Discovery's external fuel tank will be examined and foam reapplied where 89 sensors were installed on the tank's aluminum skin for an instrumented tanking test on Dec. 17. The sensors were used to measure changes in the tank as super-cold propellants were pumped in and drained out. Data and analysis from the test will be used to determine what caused the tops of two, 21-foot-long support beams, called stringers, on the outside of the intertank to crack during fueling on Nov. 5. Discovery's next launch opportunity to the International Space Station on the STS-133 mission is no earlier than Feb. 3, 2011. For more information on STS-133, visit www.nasa.gov/mission_pages/shuttle/shuttlemissions/sts133/. Photo credit: NASA/Frank Michaux

KSC-2010-5928

NASA Image and Video Library

2010-12-22

CAPE CANAVERAL, Fla. -- Space shuttle Discovery slowly moves down the crawlerway at NASA's Kennedy Space Center in Florida. The 3.4-mile trek, called rollback, from Launch Pad 39A to the Vehicle Assembly Building began at 10:48 p.m. yesterday and took about eight hours. Next, Discovery's external fuel tank will be examined and foam reapplied where 89 sensors were installed on the tank's aluminum skin for an instrumented tanking test on Dec. 17. The sensors were used to measure changes in the tank as super-cold propellants were pumped in and drained out. Data and analysis from the test will be used to determine what caused the tops of two, 21-foot-long support beams, called stringers, on the outside of the intertank to crack during fueling on Nov. 5. Discovery's next launch opportunity to the International Space Station on the STS-133 mission is no earlier than Feb. 3, 2011. For more information on STS-133, visit www.nasa.gov/mission_pages/shuttle/shuttlemissions/sts133/. Photo credit: NASA/Frank Michaux

KSC-2010-5926

NASA Image and Video Library

2010-12-21

CAPE CANAVERAL, Fla. -- Space shuttle Discovery, secured to a crawler-transporter, slowly moves away from Launch Pad 39A at NASA's Kennedy Space Center in Florida. The 3.4-mile trek, called rollback, to the Vehicle Assembly Building began at 10:48 p.m. and took about eight hours. Next, Discovery's external fuel tank will be examined and foam reapplied where 89 sensors were installed on the tank's aluminum skin for an instrumented tanking test on Dec. 17. The sensors were used to measure changes in the tank as super-cold propellants were pumped in and drained out. Data and analysis from the test will be used to determine what caused the tops of two, 21-foot-long support beams, called stringers, on the outside of the intertank to crack during fueling on Nov. 5. Discovery's next launch opportunity to the International Space Station on the STS-133 mission is no earlier than Feb. 3, 2011. For more information on STS-133, visit www.nasa.gov/mission_pages/shuttle/shuttlemissions/sts133/. Photo credit: NASA/Frank Michaux

KSC-2010-5929

NASA Image and Video Library

2010-12-22

CAPE CANAVERAL, Fla. -- Space shuttle Discovery slowly moves down the crawlerway at NASA's Kennedy Space Center in Florida. The 3.4-mile trek, called rollback, from Launch Pad 39A to the Vehicle Assembly Building began at 10:48 p.m. yesterday and took about eight hours. Next, Discovery's external fuel tank will be examined and foam reapplied where 89 sensors were installed on the tank's aluminum skin for an instrumented tanking test on Dec. 17. The sensors were used to measure changes in the tank as super-cold propellants were pumped in and drained out. Data and analysis from the test will be used to determine what caused the tops of two, 21-foot-long support beams, called stringers, on the outside of the intertank to crack during fueling on Nov. 5. Discovery's next launch opportunity to the International Space Station on the STS-133 mission is no earlier than Feb. 3, 2011. For more information on STS-133, visit www.nasa.gov/mission_pages/shuttle/shuttlemissions/sts133/. Photo credit: NASA/Frank Michaux

State recovery and lockstep execution restart in a system with multiprocessor pairing

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gara, Alan; Gschwind, Michael K; Salapura, Valentina

System, method and computer program product for a multiprocessing system to offer selective pairing of processor cores for increased processing reliability. A selective pairing facility is provided that selectively connects, i.e., pairs, multiple microprocessor or processor cores to provide one highly reliable thread (or thread group). Each paired microprocessor or processor cores that provide one highly reliable thread for high-reliability connect with a system components such as a memory "nest" (or memory hierarchy), an optional system controller, and optional interrupt controller, optional I/O or peripheral devices, etc. The memory nest is attached to a selective pairing facility via a switchmore » or a bus. Each selectively paired processor core is includes a transactional execution facility, whereing the system is configured to enable processor rollback to a previous state and reinitialize lockstep execution in order to recover from an incorrect execution when an incorrect execution has been detected by the selective pairing facility.« less

Performance enhancement of various real-time image processing techniques via speculative execution

NASA Astrophysics Data System (ADS)

Younis, Mohamed F.; Sinha, Purnendu; Marlowe, Thomas J.; Stoyenko, Alexander D.

1996-03-01

In real-time image processing, an application must satisfy a set of timing constraints while ensuring the semantic correctness of the system. Because of the natural structure of digital data, pure data and task parallelism have been used extensively in real-time image processing to accelerate the handling time of image data. These types of parallelism are based on splitting the execution load performed by a single processor across multiple nodes. However, execution of all parallel threads is mandatory for correctness of the algorithm. On the other hand, speculative execution is an optimistic execution of part(s) of the program based on assumptions on program control flow or variable values. Rollback may be required if the assumptions turn out to be invalid. Speculative execution can enhance average, and sometimes worst-case, execution time. In this paper, we target various image processing techniques to investigate applicability of speculative execution. We identify opportunities for safe and profitable speculative execution in image compression, edge detection, morphological filters, and blob recognition.

KSC-2010-5930

NASA Image and Video Library

2010-12-22

CAPE CANAVERAL, Fla. -- Space shuttle Discovery approached the Vehicle Assembly Building at NASA's Kennedy Space Center in Florida. The 3.4-mile trek, called rollback, from Launch Pad 39A began at 10:48 p.m. yesterday and took about eight hours. Next, Discovery's external fuel tank will be examined and foam reapplied where 89 sensors were installed on the tank's aluminum skin for an instrumented tanking test on Dec. 17. The sensors were used to measure changes in the tank as super-cold propellants were pumped in and drained out. Data and analysis from the test will be used to determine what caused the tops of two, 21-foot-long support beams, called stringers, on the outside of the intertank to crack during fueling on Nov. 5. Discovery's next launch opportunity to the International Space Station on the STS-133 mission is no earlier than Feb. 3, 2011. For more information on STS-133, visit www.nasa.gov/mission_pages/shuttle/shuttlemissions/sts133/. Photo credit: NASA/Frank Michaux

KSC-2010-5922

NASA Image and Video Library

2010-12-21

CAPE CANAVERAL, Fla. -- Space shuttle Discovery, secured to a crawler-transporter, slowly moves away from Launch Pad 39A at NASA's Kennedy Space Center in Florida. The 3.4-mile trek, called rollback, to the Vehicle Assembly Building began at 10:48 p.m. and took about eight hours. Next, Discovery's external fuel tank will be examined and foam reapplied where 89 sensors were installed on the tank's aluminum skin for an instrumented tanking test on Dec. 17. The sensors were used to measure changes in the tank as super-cold propellants were pumped in and drained out. Data and analysis from the test will be used to determine what caused the tops of two, 21-foot-long support beams, called stringers, on the outside of the intertank to crack during fueling on Nov. 5. Discovery's next launch opportunity to the International Space Station on the STS-133 mission is no earlier than Feb. 3, 2011. For more information on STS-133, visit www.nasa.gov/mission_pages/shuttle/shuttlemissions/sts133/. Photo credit: NASA/Frank Michaux

KSC-2010-5931

NASA Image and Video Library

2010-12-22

CAPE CANAVERAL, Fla. -- Space shuttle Discovery begins to enter the Vehicle Assembly Building at NASA's Kennedy Space Center in Florida. The 3.4-mile trek, called rollback, from Launch Pad 39A began at 10:48 p.m. yesterday and took about eight hours. Next, Discovery's external fuel tank will be examined and foam reapplied where 89 sensors were installed on the tank's aluminum skin for an instrumented tanking test on Dec. 17. The sensors were used to measure changes in the tank as super-cold propellants were pumped in and drained out. Data and analysis from the test will be used to determine what caused the tops of two, 21-foot-long support beams, called stringers, on the outside of the intertank to crack during fueling on Nov. 5. Discovery's next launch opportunity to the International Space Station on the STS-133 mission is no earlier than Feb. 3, 2011. For more information on STS-133, visit www.nasa.gov/mission_pages/shuttle/shuttlemissions/sts133/. Photo credit: NASA/Frank Michaux

KSC-2010-5921

NASA Image and Video Library

2010-12-21

CAPE CANAVERAL, Fla. -- Space shuttle Discovery, secured to a crawler-transporter, slowly moves away from Launch Pad 39A at NASA's Kennedy Space Center in Florida. The 3.4-mile trek, called rollback, to the Vehicle Assembly Building began at 10:48 p.m. and took about eight hours. Next, Discovery's external fuel tank will be examined and foam reapplied where 89 sensors were installed on the tank's aluminum skin for an instrumented tanking test on Dec. 17. The sensors were used to measure changes in the tank as super-cold propellants were pumped in and drained out. Data and analysis from the test will be used to determine what caused the tops of two, 21-foot-long support beams, called stringers, on the outside of the intertank to crack during fueling on Nov. 5. Discovery's next launch opportunity to the International Space Station on the STS-133 mission is no earlier than Feb. 3, 2011. For more information on STS-133, visit www.nasa.gov/mission_pages/shuttle/shuttlemissions/sts133/. Photo credit: NASA/Frank Michaux

KSC-01pp1276

NASA Image and Video Library

2001-07-11

KENNEDY SPACE CENTER, Fla. -- After RSS rollback, Space Shuttle Atlantis is ready for final launch preparations. The orbiter access arm, with the environmentally controlled White Room at the end, is extended to the orbiter to allow entry into Atlantis. Above it is the gaseous oxygen vent arm with its characteristic “beanie cap” or hood placed over the external tank. The retractable arm and vent hood assembly allows gaseous oxygen vapors to vent away from the Space Shuttle vehicle. The vapors are created as the liquid oxygen in the external tank boils off. At the lower end of Atlantis are the tail service masts, in front of either wing. The masts support the fluid, gas and electrical requirements of the orbiter’s liquid oxygen and liquid hydrogen aft T-0 umbilicals. Launch on mission STS-104 is scheduled for 5:04 a.m. July 12. The launch is the 10th assembly flight to the International Space Station. Along with a crew of five, Atlantis will carry the joint airlock module as primary payload

KSC-08pd3265

NASA Image and Video Library

2008-10-20

CAPE CANAVERAL, Fla. - In the early morning hours, space shuttle Atlantis begins to roll away from Launch Pad 39A at NASA's Kennedy Space Center in Florida. First motion was at 6:48 a.m. EDT. At left are the fixed service structure topped by its 80-foot lightning mast and the rotating service structure. At far left is the 300,000-gallon water tower, which contents are used for sound suppression during liftoff. Atlantis is rolling back to the Vehicle Assembly Building to await launch on its STS-125 mission to repair NASA's Hubble Space Telescope. Atlantis' targeted launch on Oct. 14 was delayed when a system that transfers science data from the orbiting observatory to Earth malfunctioned on Sept. 27. The new target launch date is under review. The space shuttle is mounted on a Mobile Launcher Platform and will be delivered to the Vehicle Assembly Building atop a crawler transporter. traveling slower than 1 mph during the 3.4-mile journey. The rollback is expected to take approximately six hours. Photo credit: NASA/Kim Shiflett

KSC-08pd3271

NASA Image and Video Library

2008-10-20

CAPE CANAVERAL, Fla. - Next to the waters of the Banana River, space shuttle Atlantis rolls away from the rotating and fixed service structures on Launch Pad 39A at NASA's Kennedy Space Center in Florida. At far right is Launch Pad 39B where space shuttle Endeavour is seen. First motion of Atlantis was at 6:48 a.m. EDT. Atlantis is rolling back to the Vehicle Assembly Building to await launch on its STS-125 mission to repair NASA's Hubble Space Telescope. Atlantis' targeted launch on Oct. 14 was delayed when a system that transfers science data from the orbiting observatory to Earth malfunctioned on Sept. 27. The new target launch date is under review. The space shuttle is mounted on a Mobile Launcher Platform and will be delivered to the Vehicle Assembly Building atop a crawler transporter. traveling slower than 1 mph during the 3.4-mile journey. The rollback is expected to take approximately six hours. Photo credit: NASA/Kim Shiflett

KSC-2011-6779

NASA Image and Video Library

2011-09-07

CAPE CANAVERAL, Fla. -- At Space Launch Complex 17B on Cape Canaveral Air Force Station, view of the United Launch Alliance Delta II rocket that will launch NASA's Gravity Recovery and Interior Laboratory mission is unobstructed as the mobile service tower rolls away. The "rollback" began at about 11:20 p.m. EDT. GRAIL will fly twin spacecraft in tandem around the moon to precisely measure and map variations in the moon's gravitational field. The mission will provide the most accurate global gravity field to date for any planet, including Earth. This detailed information will reveal differences in the density of the moon's crust and mantle and will help answer fundamental questions about the moon's internal structure, thermal evolution, and history of collisions with asteroids. The aim is to map the moon's gravity field so completely that future lunar vehicles can safely navigate anywhere on the moon’s surface. Launch is scheduled for 8:37:06 a.m. EDT Sept. 8. For more information, visit http://www.nasa.gov/grail. Photo credit: NASA/Kim Shiflett

KSC-2011-6786

NASA Image and Video Library

2011-09-08

CAPE CANAVERAL, Fla. -- At Space Launch Complex 17B on Cape Canaveral Air Force Station, the United Launch Alliance Delta II rocket that will launch NASA's Gravity Recovery and Interior Laboratory mission undergoes final preparations for launch. The "rollback" of the mobile service tower began at about 11:20 p.m. EDT Sept. 7. GRAIL will fly twin spacecraft in tandem around the moon to precisely measure and map variations in the moon's gravitational field. The mission will provide the most accurate global gravity field to date for any planet, including Earth. This detailed information will reveal differences in the density of the moon's crust and mantle and will help answer fundamental questions about the moon's internal structure, thermal evolution, and history of collisions with asteroids. The aim is to map the moon's gravity field so completely that future lunar vehicles can safely navigate anywhere on the moon’s surface. Launch is scheduled for 8:37:06 a.m. EDT Sept. 8. For more information, visit http://www.nasa.gov/grail. Photo credit: NASA/Kim Shiflett

KSC-01pp1234

NASA Image and Video Library

2001-06-30

KENNEDY SPACE CENTER, Fla. -- The Boeing Delta II rocket is poised for flight on Launch Complex 17-A, Cape Canaveral Air Force Station, after rollback of the Mobile Service Tower. Topping the rocket is the payload, the Microwave Anisotropy Probe (MAP) spacecraft. Launch is scheduled at 3:46 p.m. EDT June 30. The launch will place MAP into a lunar-assisted trajectory to the Sun-Earth for a 27-month mission. The probe will measure small fluctuations in the temperature of the cosmic microwave background radiation to an accuracy of one millionth of a degree. These measurements should reveal the size, matter content, age, geometry and fate of the universe. They will also reveal the primordial structure that grew to form galaxies and will test ideas about the origins of these primordial structures. The MAP instrument will be continuously shaded from the Sun, Earth, and Moon by the spacecraft. The probe is a product of Goddard Space Flight Center in partnership with Princeton University

KSC01padig235

NASA Image and Video Library

2001-06-30

KENNEDY SPACE CENTER, Fla. -- The Boeing Delta II rocket is poised for flight on Launch Complex 17-A, Cape Canaveral Air Force Station, after rollback of the Mobile Service Tower (right). Topping the rocket is the payload, the Microwave Anisotropy Probe (MAP) spacecraft. Launch is scheduled at 3:46 p.m. EDT June 30. The launch will place MAP into a lunar-assisted trajectory to the Sun-Earth for a 27-month mission. The probe will measure small fluctuations in the temperature of the cosmic microwave background radiation to an accuracy of one millionth of a degree. These measurements should reveal the size, matter content, age, geometry and fate of the universe. They will also reveal the primordial structure that grew to form galaxies and will test ideas about the origins of these primordial structures. The MAP instrument will be continuously shaded from the Sun, Earth, and Moon by the spacecraft. The probe is a product of Goddard Space Flight Center in partnership with Princeton University

A Domain Decomposition Parallelization of the Fast Marching Method

NASA Technical Reports Server (NTRS)

Herrmann, M.

2003-01-01

In this paper, the first domain decomposition parallelization of the Fast Marching Method for level sets has been presented. Parallel speedup has been demonstrated in both the optimal and non-optimal domain decomposition case. The parallel performance of the proposed method is strongly dependent on load balancing separately the number of nodes on each side of the interface. A load imbalance of nodes on either side of the domain leads to an increase in communication and rollback operations. Furthermore, the amount of inter-domain communication can be reduced by aligning the inter-domain boundaries with the interface normal vectors. In the case of optimal load balancing and aligned inter-domain boundaries, the proposed parallel FMM algorithm is highly efficient, reaching efficiency factors of up to 0.98. Future work will focus on the extension of the proposed parallel algorithm to higher order accuracy. Also, to further enhance parallel performance, the coupling of the domain decomposition parallelization to the G(sub 0)-based parallelization will be investigated.

Monetization of Nigeria coal by conversion to hydrocarbon fuels through Fischer-Tropsch process

DOE Office of Scientific and Technical Information (OSTI.GOV)

Oguejiofor, G.C.

Given the instability of crude oil prices and the disruptions in crude oil supply chains, this article offers a complementing investment proposal through diversification of Nigeria's energy source and dependence. Therefore, the following issues were examined and reported: A comparative survey of coal and hydrocarbon reserve bases in Nigeria was undertaken and presented. An excursion into the economic, environmental, and technological justifications for the proposed diversification and roll-back to coal-based resource was also undertaken and presented. The technology available for coal beneficiation for environmental pollution control was reviewed and reported. The Fischer-Tropsch synthesis and its advances into Sasol's slurry phasemore » distillate process were reviewed. Specifically, the adoption of Sasol's advanced synthol process and the slurry phase distillate process were recommended as ways of processing the products of coal gasification. The article concludes by discussing all the above-mentioned issues with regard to value addition as a means of wealth creation and investment.« less

Comprehensive haematological indices reference intervals for a healthy Omani population: First comprehensive study in Gulf Cooperation Council (GCC) and Middle Eastern countries based on age, gender and ABO blood group comparison.

PubMed

Al-Mawali, Adhra; Pinto, Avinash Daniel; Al-Busaidi, Raiya; Al-Lawati, Rabab H; Morsi, Magdi

2018-01-01

Reference intervals for venous blood parameters differs with age, gender, geographic region, and ethnic groups. Hence local laboratory reference intervals are important to improve the diagnostic accuracy of health assessments and diseases. However, there have been no comprehensive published reference intervals established in Oman, the Gulf Cooperation Council or Middle Eastern countries. Hence, the aim of this study was to establish reference intervals for full blood count in healthy Omani adults. Venous blood specimens were collected from 2202 healthy individuals aged 18 to 69 years from January 2012 to April 2017, and analysed by Sysmex XS-1000i and Cell-Dyn Sapphire automated haematology analysers. Results were statistically analysed and compared by gender, age, and ABO blood group. The lower and upper reference limits of the haematology reference intervals were established at the 2.5th and 97.5th percentiles respectively. Reference intervals were calculated for 17 haematology parameters which included red blood cell, white blood cell, and platelet parameters. Red blood cell (RBC), haemoglobin (HGB), haematocrit (HCT), platelet and platelet haematocrit counts of the healthy donors were significantly different between males and females at all ages (p < 0.05), with males having higher mean values of RBC, HGB and HCT than females. Other complete blood count parameters showed no significant differences between genders, age groups, instruments, or blood groups. Our study showed a lower haemoglobin limit for the normal reference interval in males and females than the currently used in Oman. Data from this study established specific reference intervals which could be considered for general use in Oman. The differences in haematology reference intervals highlights the necessity to establish reference intervals for venous blood parameters among the healthy population in each country or at least in each region.

Exploring versioned distributed arrays for resilience in scientific applications: Global view resilience

DOE PAGES

Chien, Andrew A.; Balaji, Pavan; Dun, Nan; ...

2016-09-08

Exascale studies project reliability challenges for future HPC systems. We present the Global View Resilience (GVR) system, a library for portable resilience. GVR begins with a subset of the Global Arrays interface, and adds new capabilities to create versions, name versions, and compute on version data. Applications can focus versioning where and when it is most productive, and customize for each application structure independently. This control is portable, and its embedding in application source makes it natural to express and easy to maintain. The ability to name multiple versions and “partially materialize” them efficiently makes ambitious forward-recovery based on “datamore » slices” across versions or data structures both easy to express and efficient. Using several large applications (OpenMC, preconditioned conjugate gradient (PCG) solver, ddcMD, and Chombo), we evaluate the programming effort to add resilience. The required changes are small (< 2% lines of code (LOC)), localized and machine-independent, and perhaps most important, require no software architecture changes. We also measure the overhead of adding GVR versioning and show that overheads < 2% are generally achieved. This overhead suggests that GVR can be implemented in large-scale codes and support portable error recovery with modest investment and runtime impact. Our results are drawn from both IBM BG/Q and Cray XC30 experiments, demonstrating portability. We also present two case studies of flexible error recovery, illustrating how GVR can be used for multi-version rollback recovery, and several different forward-recovery schemes. GVR’s multi-version enables applications to survive latent errors (silent data corruption) with significant detection latency, and forward recovery can make that recovery extremely efficient. Lastly, our results suggest that GVR is scalable, portable, and efficient. GVR interfaces are flexible, supporting a variety of recovery schemes, and altogether GVR embodies a gentle-slope path to tolerate growing error rates in future extreme-scale systems.« less

On the Role of Subduction Dynamics on Emplacement of Metamorphic Core Complexes and Geothermal Systems

NASA Astrophysics Data System (ADS)

Roche, V. M.; Sternai, P.; Guillou-Frottier, L.; Menant, A.; Jolivet, L.; Bouchot, V.; Gerya, T.

2017-12-01

Subduction-induced extensional tectonics in back-arc domains results in the development of metamorphic core complexes (MCCs) and low-angle normal faults (detachments) that also control magma ascent and fluid circulation. However, possible links with the genesis of high-enthalpy geothermal resources (HEGRs) remain barely explored, and no unifying mechanism responsible for both the generation of MCCs and emplacement of HEGRs has yet been recognized. Although discussions on the possible role of magmatic intrusions beneath these systems are still active, another source of heat is required when one considers the scale of a geothermal Province. An additional source of heat, for instance, could arise from the deep dynamics implied by large-scale tectonic processes such as subduction. Firstly, we investigate subduction dynamics through 3D numerical geodynamic models involving slab rollback and tearing constrained primarily by, geothermal anomaly measurements from western Turkey. Our results show that subduction-induced extensional tectonics controls the genesis and distribution of crustal-scale thermal domes, analogous to crustal and lithospheric boudinage. The thermal domes weaken the crust, localize deformation and enhance development of crustal-scale detachments. Thus, these thermo-mechanical instabilities primarily trigger and control the distribution of MCCs. In addition, subduction-related asthenospheric return flow and shear heating in the mantle increase the temperature of the Moho by up to 250°C. Such forcing is observed in natural settings such as the Menderes (western Anatolia) and the Basin and Range (Western United States). Secondly, the numerically-obtained subduction-induced thermal signature at the base of the continental crust is then imposed as basal thermal condition for 2D high-resolution crustal models dedicated to the understanding of fluid flow around detachments. Our results show that permeable detachments control the bulk of the heat transport and fluid circulation patterns at shallow depth, thus creating favourable zones for HEGRS, as illustrated in the Menderes Massif and in the Basin & Range province.

Initiation of Extension in South China Continental Margin during the Active-Passive Margin Transition: Thermochronological and Kinematic Constraints

NASA Astrophysics Data System (ADS)

Zuo, X.; Chan, L. S.

2015-12-01

The South China continental margin is characterized by a widespread magmatic belt, prominent NE-striking faults and numerous rifted basins filled by Cretaceous-Eocene sediments. The geology denotes a transition from active to passive margin, which led to rapid modifications of crustal stress configuration and reactivation of older faults in this area. Our zircon fission-track data in this region show two episodes of exhumation: The first episode, occurring during 170-120Ma, affected local parts of the Nanling Range. The second episode, a more regional exhumation event, occurred during 115-70Ma, including the Yunkai Terrane and the Nanling Range. Numerical geodynamic modeling was conducted to simulate the subduction between the paleo-Pacific plate and the South China Block. The modeling results could explain the fact that exhumation of the granite-dominant Nanling Range occurred earlier than that of the gneiss-dominant Yunkai Terrane. In addition to the difference in rock types, the heat from Jurassic-Early Cretaceous magmatism in Nanling may have softened the upper crust, causing the area to exhume more readily than Yunkai. Numerical modeling results also indicate that (1) high lithospheric geothermal gradient, high slab dip angle and low convergence velocity favor the reversal of crustal stress state from compression to extension in the upper continental plate; (2) late Mesozoic magmatism in South China was probably caused by a slab roll-back; and (3) crustal extension could have occurred prior to the cessation of plate subduction. The inversion of stress regime in the continental crust from compression to crustal extension imply that the Late Cretaceous-early Paleogene red-bed basins in South China could have formed during the late stage of the subduction, accounting for the occurrence of volcanic events in some sedimentary basins. We propose that the rifting started as early as Late Cretaceous, probably before the cessation of subduction process.

Exploring versioned distributed arrays for resilience in scientific applications: Global view resilience

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chien, Andrew A.; Balaji, Pavan; Dun, Nan

Exascale studies project reliability challenges for future HPC systems. We present the Global View Resilience (GVR) system, a library for portable resilience. GVR begins with a subset of the Global Arrays interface, and adds new capabilities to create versions, name versions, and compute on version data. Applications can focus versioning where and when it is most productive, and customize for each application structure independently. This control is portable, and its embedding in application source makes it natural to express and easy to maintain. The ability to name multiple versions and “partially materialize” them efficiently makes ambitious forward-recovery based on “datamore » slices” across versions or data structures both easy to express and efficient. Using several large applications (OpenMC, preconditioned conjugate gradient (PCG) solver, ddcMD, and Chombo), we evaluate the programming effort to add resilience. The required changes are small (< 2% lines of code (LOC)), localized and machine-independent, and perhaps most important, require no software architecture changes. We also measure the overhead of adding GVR versioning and show that overheads < 2% are generally achieved. This overhead suggests that GVR can be implemented in large-scale codes and support portable error recovery with modest investment and runtime impact. Our results are drawn from both IBM BG/Q and Cray XC30 experiments, demonstrating portability. We also present two case studies of flexible error recovery, illustrating how GVR can be used for multi-version rollback recovery, and several different forward-recovery schemes. GVR’s multi-version enables applications to survive latent errors (silent data corruption) with significant detection latency, and forward recovery can make that recovery extremely efficient. Lastly, our results suggest that GVR is scalable, portable, and efficient. GVR interfaces are flexible, supporting a variety of recovery schemes, and altogether GVR embodies a gentle-slope path to tolerate growing error rates in future extreme-scale systems.« less

The dynamic history of the Trans-Mexican Volcanic Belt and the Mexico subduction zone

NASA Astrophysics Data System (ADS)

Ferrari, Luca; Orozco-Esquivel, Teresa; Manea, Vlad; Manea, Marina

2012-02-01

The Trans-Mexican Volcanic Belt (TMVB) is a 1000 km long Neogene continental arc showing a large variation in composition and volcanic style, and an intra-arc extensional tectonics. It overlies the Rivera and Cocos slabs, which display marked changes in geometry. Geophysical studies indicate that lithospheric mantle is very thin or absent beneath the forearc and arc, the fluids from the slab are released in a 40 to 100 km wide belt beneath the frontal part of the arc, and the lower crust beneath the arc is partially molten. East of 101°W the TMVB is built on a Precambrian to Paleozoic crust with thickness of 50-55 km. West of 101°W the TMVB is underlain by Jurassic to Cenozoic marine and continental arcs with a 35-40 km thick crust. The evolution of the TMVB occurred in four stages: 1) from ~ 20 to 10 Ma the initial andesitic arc moved inland showing progressively drier melting and, eventually, slab melting, suggesting flattening of the subducted slab; 2) since ~ 11 Ma a pulse of mafic volcanism migrated from west to east reaching the Gulf of Mexico by 7 Ma. This mafic lavas marks the lateral propagation of a slab tear, triggered by cessation of subduction beneath Baja California; 3) thereafter, the volcanic front started moving trenchward, with a marked phase of silicic volcanism between 7.5 and 3 Ma, local emplacement of small volume intraplate-like basalts since 5 Ma, and development of extensional faulting. These features are related to slab rollback, enhancing asthenophere flux into the mantle wedge and promoting partial melting of the crust; 4) the modern arc consists of a frontal belt dominated by flux and slab melting, and a rear belt characterized by more differentiated rocks or by mafic lavas with little or no evidence of subduction fluids but higher asthenosphere fingerprint.

Crustal Strike-Slip Faulting along Small Circle Paths in the Northwestern United States

NASA Astrophysics Data System (ADS)

Brocher, T. M.; Wells, R. E.; Lamb, A. P.; Weaver, C. S.

2015-12-01

Late Cenozoic and Quaternary faults, seismicity lineaments, and focal mechanisms provide evidence that clockwise rotation of Washington and Oregon is accommodated by north-directed thrusting and strike-slip deformation in the Washington segment of the Cascadia forearc. Curvilinear NW- to NNW-trending high-angle strike-slip faults and seismicity lineaments define small circles around an Euler pole (117.7°W, 47.9°N) of rotation relative to North America that approximates GPS-derived poles for the rotation of eastern Washington and the Snake River Plain. Although the lengths of strike-slip faults that follow small circle paths suggest maximum earthquake magnitudes of M6.6 to M7.2, their slip rates calculated from the Euler pole are low (0.3 to 0.5 mm/yr). Many normal faults in the Lewis and Clark Zone in Montana, the Centennial fault system north of the Snake River Plain, west of the Wasatch Front, in the northern Basin and Range, and locally east of the Oregon Cascade arc are radial to this pole of rotation, suggesting that these normal faults help accommodate this crustal rotation. Regions undergoing contraction in western Washington and northwestern Oregon are separated from those to the east undergoing extension by lines radial to the Euler pole. In our regional kinematic model, dextral faults along small circles connect SW-directed crustal extension in the Intermountain Seismic Belt and E-directed extension in the Cascade arc south of Mount Hood to N-directed contraction in the Olympic Peninsula, Puget Lowland, and the Yakima Fold and Thrust Belt. The lack of Quaternary faulting and seismicity in the Oregon segment of the forearc is consistent with its clockwise rotation as a rigid block. Potential drivers of the crustal rotation include westward slab rollback and the Yellowstone geoid high, and the overall velocity field may integrate the response of rotating blocks and distributed deformation between them.

Quantum jumps on Anderson attractors

NASA Astrophysics Data System (ADS)

Yusipov, I. I.; Laptyeva, T. V.; Ivanchenko, M. V.

2018-01-01

In a closed single-particle quantum system, spatial disorder induces Anderson localization of eigenstates and halts wave propagation. The phenomenon is vulnerable to interaction with environment and decoherence that is believed to restore normal diffusion. We demonstrate that for a class of experimentally feasible non-Hermitian dissipators, which admit signatures of localization in asymptotic states, quantum particle opts between diffusive and ballistic regimes, depending on the phase parameter of dissipators, with sticking about localization centers. In a diffusive regime, statistics of quantum jumps is non-Poissonian and has a power-law interval, a footprint of intermittent locking in Anderson modes. Ballistic propagation reflects dispersion of an ordered lattice and introduces the second timescale for jumps, resulting in non-nonmonotonous probability distribution. Hermitian dephasing dissipation makes localization features vanish, and Poissonian jump statistics along with normal diffusion are recovered.

The Effects of Local Anaesthetics on QT Parameters during Thoracic Epidural Anaesthesia Combined with General Anaesthesia: Ropivacaine versus Bupivacaine

PubMed Central

Güven, Özlem; Sazak, Hilal; Alagöz, Ali; Şavkılıoğlu, Eser; Demirbaş, Çilsem Sevgen; Yıldız, Ali; Karabulut, Erdem

2013-01-01

Background: Many studies focusing on the effects of local anaesthetics on QT intervals have been performed, but the articles evaluating the relationship between thoracic epidural anaesthesia combined with general anaesthesia and QT parameters are very limited. Aims: We aimed to compare the effects of bupivacaine and ropivacaine on QT interval, corrected QT, dispersion of QT, and corrected dispersion of QT in patients undergoing lung resection under thoracic epidural anaesthesia combined with general anaesthesia. Study Design: Prospective clinical study. Methods: Thirty ASA physical status 1–3 patients requiring thoracic epidural anaesthesia combined with general anaesthesia for thoracic surgery. Patients were randomly assigned to two groups, which were allocated to receive either bupivacaine (Group B) or ropivacaine (Group R) during thoracic epidural anaesthesia. Following haemodynamic monitoring, a thoracic epidural catheter was inserted. Local anaesthetic at an average dose of 1.5 mL/ segment was given through an epidural catheter. The same general anaesthesia protocol was administered in both groups. Records and measurements were performed on 10 phases that were between the thoracic epidural catheter insertion to the 5th min of endobronchial intubation. In all phases, systolic arterial pressure, diastolic arterial pressure, mean arterial pressure, heart rate, peripheral O2 saturation, and electrocardiogram monitoring were performed in patients. All QT parameters were recorded by 12-lead electrocardiogram and analysed manually by a cardiologist. Results: QT intervals were similar between two groups. In Group R, corrected QT values at the 20th min of local anaesthetic injection and the 5th min of endobronchial intubation were shorter than those in Group B (p<0.05). The basal dispersion of QT and dispersion of QT values at the 1st min of propofol injection were shorter than those in Group R (p<0.05). The corrected dispersion of QT value at the 1st min of propofol injection was shorter in Group R (p<0.05). In Group R, the decrease in mean arterial pressure at the 1st min of fentanyl injection was significant compared with Group B (p<0.05). There was no significant difference between the groups with respect to heart rate and complications. Conclusion: The corrected QT, dispersion of QT, and corrected dispersion of QT intervals were slightly longer in the patients receiving bupivacaine compared with those receiving ropivacaine in various phases of the present study. PMID:25207150

A string of Peregrine rogue waves in the nonlocal nonlinear Schrödinger equation with parity-time symmetric self-induced potential

NASA Astrophysics Data System (ADS)

Gupta, Samit Kumar

2018-03-01

Dynamic wave localization phenomena draw fundamental and technological interests in optics and photonics. Based on the recently proposed (Ablowitz and Musslimani, 2013) continuous nonlocal nonlinear Schrödinger system with parity-time symmetric Kerr nonlinearity (PTNLSE), a numerical investigation has been carried out for two first order Peregrine solitons as the initial ansatz. Peregrine soliton, as an exact solution to the PTNLSE, evokes a very potent question: what effects does the interaction of two first order Peregrine solitons have on the overall optical field dynamics. Upon numerical computation, we observe the appearance of Kuznetsov-Ma (KM) soliton trains in the unbroken PT-phase when the initial Peregrine solitons are in phase. In the out of phase condition, it shows repulsive nonlinear waves. Quite interestingly, our study shows that within a specific range of the interval factor in the transverse co-ordinate there exists a string of high intensity well-localized Peregrine rogue waves in the PT unbroken phase. We note that the interval factor as well as the transverse shift parameter play important roles in the nonlinear interaction and evolution dynamics of the optical fields. This could be important in developing fundamental understanding of nonlocal non-Hermitian NLSE systems and dynamic wave localization behaviors.

Analysis of RGU Photometry in Selected Area 51

NASA Astrophysics Data System (ADS)

Bilir, S.; Karaali, S.; Buser, R.

2004-09-01

A low-latitude anticenter field (l=189 °, b=+21 °) is investigated by using the full calibration tools of RGU photometry. The observed RGU data are reduced to the standard system and the separation of dwarfs and evolved stars is carried out by an empirical method. Stars are categorized into three metallicity classes, i.e. -0.25<[M/H]≤+0.50, $-1.00<[M/H]≤-0.25, and [M/H]≤-1.00 dex, and their absolute magnitudes are determined by the corresponding color-magnitude diagrams. The unusually large scattering in the two-color diagrams is reduced by excluding 153 extra-galactic objects, identifying them compared with the charts of Basel Astronomical Institute and University of Minnesota, and by the criterion and algorithm of Gaidos et al. [1]. The local logarithmic space density for giants, D*(0)=6.75, lies within the local densities of Gliese and Gliese & Jahreiss. The local luminosity function in our work for the absolute magnitude interval 3

Influence of double stimulation on sound-localization behavior in barn owls.

PubMed

Kettler, Lutz; Wagner, Hermann

2014-12-01

Barn owls do not immediately approach a source after they hear a sound, but wait for a second sound before they strike. This represents a gain in striking behavior by avoiding responses to random incidents. However, the first stimulus is also expected to change the threshold for perceiving the subsequent second sound, thus possibly introducing some costs. We mimicked this situation in a behavioral double-stimulus paradigm utilizing saccadic head turns of owls. The first stimulus served as an adapter, was presented in frontal space, and did not elicit a head turn. The second stimulus, emitted from a peripheral source, elicited the head turn. The time interval between both stimuli was varied. Data obtained with double stimulation were compared with data collected with a single stimulus from the same positions as the second stimulus in the double-stimulus paradigm. Sound-localization performance was quantified by the response latency, accuracy, and precision of the head turns. Response latency was increased with double stimuli, while accuracy and precision were decreased. The effect depended on the inter-stimulus interval. These results suggest that waiting for a second stimulus may indeed impose costs on sound localization by adaptation and this reduces the gain obtained by waiting for a second stimulus.

Re-Irradiation of Locoregional NSCLC Recurrence Using Robotic Stereotactic Body Radiotherapy.

PubMed

Ceylan, Cemile; Hamacı, Andaç; Ayata, Hande; Berberoglu, Kezban; Kılıç, Ayhan; Güden, Metin; Engin, Kayıhan

2017-01-01

We evaluated the efficacy, toxicity, and dose responses of re-irradiation with stereotactic body radiotherapy (SBRT) in patients with recurrent non- small cell lung cancer (NSCLC) after previous irradiation. 28 patients were included. Previous median radiation doses were 54 and 66 Gy. The median interval time between previous radiotherapy and SBRT was 14 months. The median follow-up time after SBRT was 9 months (range 3-93 months). To evaluate the effectiveness of SBRT, local control, overall survival, and treatment-related toxicity were reported. SBRT doses and fractionation ranged from 60 to 30 Gy and from 3 to 8, respectively, according to previous doses, location of the recurrence, and interval time. 65% of tumor recurrences overlapped with previous treatment, while 35% of tumors recurred outside of the previous treatment. 4 patients had local progression after SBRT at their first follow-up. The Kaplan-Meier estimates of the 1- and 2-year actuarial overall survival were 71 and 42%, respectively. The mean survival following SBRT was 32.8 months, and the median survival was 21 months. No grade 3 or higher toxicities were observed. Robotic SBRT is a tolerable treatment option with manageable toxicity which can be used with radical or palliative intent in carefully selected patients with locally recurrent tumors after previous irradiation. © 2017 S. Karger GmbH, Freiburg.

The "Interval Walking in Colorectal Cancer" (I-WALK-CRC) study: Design, methods and recruitment results of a randomized controlled feasibility trial.

PubMed

Banck-Petersen, Anna; Olsen, Cecilie K; Djurhuus, Sissal S; Herrstedt, Anita; Thorsen-Streit, Sarah; Ried-Larsen, Mathias; Østerlind, Kell; Osterkamp, Jens; Krarup, Peter-Martin; Vistisen, Kirsten; Mosgaard, Camilla S; Pedersen, Bente K; Højman, Pernille; Christensen, Jesper F

2018-03-01

Low physical activity level is associated with poor prognosis in patients with colorectal cancer (CRC). To increase physical activity, technology-based platforms are emerging and provide intriguing opportunities to prescribe and monitor active lifestyle interventions. The "Interval Walking in Colorectal Cancer"(I-WALK-CRC) study explores the feasibility and efficacy a home-based interval-walking intervention delivered by a smart-phone application in order to improve cardio-metabolic health profile among CRC survivors. The aim of the present report is to describe the design, methods and recruitment results of the I-WALK-CRC study.Methods/Results: The I-WALK-CRC study is a randomized controlled trial designed to evaluate the feasibility and efficacy of a home-based interval walking intervention compared to a waiting-list control group for physiological and patient-reported outcomes. Patients who had completed surgery for local stage disease and patients who had completed surgery and any adjuvant chemotherapy for locally advanced stage disease were eligible for inclusion. Between October 1st , 2015, and February 1st , 2017, 136 inquiries were recorded; 83 patients were eligible for enrollment, and 42 patients accepted participation. Age and employment status were associated with participation, as participants were significantly younger (60.5 vs 70.8 years, P < 0.001) and more likely to be working (OR 5.04; 95%CI 1.96-12.98, P < 0.001) than non-participants. In the present study, recruitment of CRC survivors was feasible but we aim to better the recruitment rate in future studies. Further, the study clearly favored younger participants. The I-WALK-CRC study will provide important information regarding feasibility and efficacy of a home-based walking exercise program in CRC survivors.

Bell's Inequalities for Any Spin

NASA Astrophysics Data System (ADS)

González-Robles, V. M.

John Ju Sakurai's classical book in quantum mechanics makes a very illuminative presentation that studies entangled states in a two spin s=1/2 particles system in a singlet state. A Bell's inequality emerges as a consequence. Bell's inequality is a relationship among observables that discriminates between Einstein's locality principle and the nonlocal point of view of orthodox quantum mechanics. Following Sakurai's style we propose, by making natural induction, a generalization for Bell's inequality for any two spin-s particles in a singlet state (s integer or half-integer). This inequality is expressed as a function of a θ parameter, which is a measure of the angle between two possible directions in which the spin is measured. Besides the expression for this general inequality we have found that - (a) for any finite half-integer spin Bell's inequality is violated for some interval of the θ-parameter. The right limit of this interval is fixed and equal to π/2, while the left one comes closer and closer to this value as spin number grows. A function fit shows clearly that the size of this θ-interval over which Bell's inequality is violated diminishes asymptotically to zero as 1/s1/2; (b) an analogous behavior for any finite integer spin. For large spins the disagreement between Einstein's locality principle and the nonlocal point of view in orthodox quantum mechanics disappears.

Extensive excitatory network interactions shape temporal processing of communication signals in a model sensory system.

PubMed

Ma, Xiaofeng; Kohashi, Tsunehiko; Carlson, Bruce A

2013-07-01

Many sensory brain regions are characterized by extensive local network interactions. However, we know relatively little about the contribution of this microcircuitry to sensory coding. Detailed analyses of neuronal microcircuitry are usually performed in vitro, whereas sensory processing is typically studied by recording from individual neurons in vivo. The electrosensory pathway of mormyrid fish provides a unique opportunity to link in vitro studies of synaptic physiology with in vivo studies of sensory processing. These fish communicate by actively varying the intervals between pulses of electricity. Within the midbrain posterior exterolateral nucleus (ELp), the temporal filtering of afferent spike trains establishes interval tuning by single neurons. We characterized pairwise neuronal connectivity among ELp neurons with dual whole cell recording in an in vitro whole brain preparation. We found a densely connected network in which single neurons influenced the responses of other neurons throughout the network. Similarly tuned neurons were more likely to share an excitatory synaptic connection than differently tuned neurons, and synaptic connections between similarly tuned neurons were stronger than connections between differently tuned neurons. We propose a general model for excitatory network interactions in which strong excitatory connections both reinforce and adjust tuning and weak excitatory connections make smaller modifications to tuning. The diversity of interval tuning observed among this population of neurons can be explained, in part, by each individual neuron receiving a different complement of local excitatory inputs.

Incidence of isolated nodal failure in non-small cell lung cancer patients included in a prospective study of the value of PET-CT.

PubMed

Kolodziejczyk, Milena; Bujko, Krzysztof; Michalski, Wojciech; Kepka, Lucyna

2012-07-01

Elective nodal irradiation (ENI) is not recommended in PET-CT-based radiotherapy for NSCLC despite a low level of evidence to support such guidelines. The aim of this investigation is to find out whether omitting ENI is safe. Sixty-seven patients treated within a frame of a previously published prospective trial of the value of PET-CT were included in the analysis. Seventeen (25%) patients received ENI due to higher initial nodal involvement and in the remaining 50 patients (75%) with N0-N1 or single N2 disease ENI was omitted. Isolated nodal failure (INF) was recorded if relapse occurred in the initially uninvolved regional lymph node without previous or simultaneous local recurrence regardless of the status of distant metastases. With a median follow-up of 32 months, the estimated 3-year overall survival was 42%, local progression-free interval was 55%, and distant metastases-free interval was 62%. Three patients developed INF; all had ENI omitted from treatment, giving a final result of three INFs in 50 (6%) patients treated without ENI. In this group of patients, the 3-year cause-specific cumulative incidence of INF was 6.4% (95% confidence interval: 0-17%). The omission of ENI appears to be not as safe as suggested by current recommendations. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

Continuous Transversus Abdominis Plane Nerve Blocks: Does Varying Local Anesthetic Delivery Method-Automatic Repeated Bolus Versus Continuous Basal Infusion-Influence the Extent of Sensation to Cold?: A Randomized, Triple-Masked, Crossover Study in Volunteers.

PubMed

Khatibi, Bahareh; Said, Engy T; Sztain, Jacklynn F; Monahan, Amanda M; Gabriel, Rodney A; Furnish, Timothy J; Tran, Johnathan T; Donohue, Michael C; Ilfeld, Brian M

2017-04-01

It remains unknown whether continuous or scheduled intermittent bolus local anesthetic administration is preferable for transversus abdominis plane (TAP) catheters. We therefore tested the hypothesis that when using TAP catheters, providing local anesthetic in repeated bolus doses increases the cephalad-caudad cutaneous effects compared with a basal-only infusion. Bilateral TAP catheters (posterior approach) were inserted in 24 healthy volunteers followed by ropivacaine 2 mg/mL administration for a total of 6 hours. The right side was randomly assigned to either a basal infusion (8 mL/h) or bolus doses (24 mL administered every 3 hours for a total of 2 bolus doses) in a double-masked manner. The left side received the alternate treatment. The primary end point was the extent of sensory deficit as measured by cool roller along the axillary line at hour 6 (6 hours after the local anesthetic administration was initiated). Secondary end points included the extent of sensory deficit as measured by cool roller and Von Frey filaments along the axillary line and along a transverse line at the level of the anterior superior iliac spine at hours 0 to 6. Although there were statistically significant differences between treatments within the earlier part of the administration period, by hour 6 the difference in extent of sensory deficit to cold failed to reach statistical significance along the axillary line (mean = 0.9 cm; SD = 6.8; 95% confidence interval -2.0 to 3.8; P = .515) and transverse line (mean = 2.5 cm; SD = 10.1; 95% confidence interval -1.8 to 6.8; P = .244). Although the difference between treatments was statistically significant at various early time points for the horizontal, vertical, and estimated area measurements of both cold and mechanical pressure sensory deficits, no comparison remained statistically significant by hour 6. No evidence was found in this study involving healthy volunteers to support the hypothesis that changing the local anesthetic administration technique (continuous basal versus hourly bolus) when using ropivacaine 0.2% and TAP catheters at 8 mL/h and 24 mL every 3 hours significantly influences the cutaneous effects after 6 hours of administration. Additional research is required to determine whether changing variables (eg, local anesthetic concentration, basal infusion rate, bolus dose volume, and/or interval) would provide different results.

Localization and characterization of X chromosome inversion breakpoints separating Drosophila mojavensis and Drosophila arizonae.

PubMed

Cirulli, Elizabeth T; Noor, Mohamed A F

2007-01-01

Ectopic exchange between transposable elements or other repetitive sequences along a chromosome can produce chromosomal inversions. As a result, genome sequence studies typically find sequence similarity between corresponding inversion breakpoint regions. Here, we identify and investigate the breakpoint regions of the X chromosome inversion distinguishing Drosophila mojavensis and Drosophila arizonae. We localize one inversion breakpoint to 13.7 kb and localize the other to a 1-Mb interval. Using this localization and assuming microsynteny between Drosophila melanogaster and D. arizonae, we pinpoint likely positions of the inversion breakpoints to windows of less than 3000 bp. These breakpoints define the size of the inversion to approximately 11 Mb. However, in contrast to many other studies, we fail to find significant sequence similarity between the 2 breakpoint regions. The localization of these inversion breakpoints will facilitate future genetic and molecular evolutionary studies in this species group, an emerging model system for ecological genetics.

Scale-dependent Normalized Amplitude and Weak Spectral Anisotropy of Magnetic Field Fluctuations in the Solar Wind Turbulence

NASA Astrophysics Data System (ADS)

Wang, Xin; Tu, Chuanyi; Marsch, Eckart; He, Jiansen; Wang, Linghua

2016-01-01

Turbulence in the solar wind was recently reported to be anisotropic, with the average power spectral index close to -2 when sampling parallel to the local mean magnetic field B0 and close to -5/3 when sampling perpendicular to the local B0. This result was widely considered to be observational evidence for the critical balance theory (CBT), which is derived by making the assumption that the turbulence strength is close to one. However, this basic assumption has not yet been checked carefully with observational data. Here we present for the first time the scale-dependent magnetic-field fluctuation amplitude, which is normalized by the local B0 and evaluated for both parallel and perpendicular sampling directions, using two 30-day intervals of Ulysses data. From our results, the turbulence strength is evaluated as much less than one at small scales in the parallel direction. An even stricter criterion is imposed when selecting the wavelet coefficients for a given sampling direction, so that the time stationarity of the local B0 is better ensured during the local sampling interval. The spectral index for the parallel direction is then found to be -1.75, whereas the spectral index in the perpendicular direction remains close to -1.65. These two new results, namely that the value of the turbulence strength is much less than one in the parallel direction and that the angle dependence of the spectral index is weak, cannot be explained by existing turbulence theories, like CBT, and thus will require new theoretical considerations and promote further observations of solar-wind turbulence.

Exact Local Correlations and Full Counting Statistics for Arbitrary States of the One-Dimensional Interacting Bose Gas

NASA Astrophysics Data System (ADS)

Bastianello, Alvise; Piroli, Lorenzo; Calabrese, Pasquale

2018-05-01

We derive exact analytic expressions for the n -body local correlations in the one-dimensional Bose gas with contact repulsive interactions (Lieb-Liniger model) in the thermodynamic limit. Our results are valid for arbitrary states of the model, including ground and thermal states, stationary states after a quantum quench, and nonequilibrium steady states arising in transport settings. Calculations for these states are explicitly presented and physical consequences are critically discussed. We also show that the n -body local correlations are directly related to the full counting statistics for the particle-number fluctuations in a short interval, for which we provide an explicit analytic result.

40 CFR 255.41 - Procedure for revision.

Code of Federal Regulations, 2010 CFR

2010-07-01

... intervals of less than 3 years. Review and modification should include, but not be limited to, the following... for solid waste functions in the region. (b) Revisions or adjustments to the State plan may require... or boundaries should be made in consultation with local officials and be subject to the same...

Assessment of Simulated and Aquarius-Observed Sea Surface Salinity Using Salinity Measurements in Dry Tortugas National Park, Florida, U.S.A.: Application for Pseudocoral δ18O

NASA Astrophysics Data System (ADS)

Chaichitehrani, N.; DeLong, K. L.

2016-02-01

Salinity plays a critical role in ocean physics thus is a target for paleoclimatologic and paleoceanographic reconstruction. Here we assess the quality of space-borne sea surface salinity (SSS) determinations and simulated SSS versus SSS measurements from an open ocean coral reef site, Dry Tortugas National Park (DTNP). The oxygen isotopic composition of seawater (δ18Osw) is related to SSS, thus SSS can be used to understand δ18Osw variability when measurements of δ18Osw are sparse. In marine carbonates such as corals, δ18Ocoral varies with temperature and δ18Osw creating a bivariate system, which is difficult to calibrate with two variables. Accurate determinations of SSS from satellites and simulations can be substituted for local SSS, converted to δ18Osw, in bivariate forward models to estimate δ18Ocoral or pseudocoral thus improving calibrations of δ18Ocoral for locations and time intervals without in situ observations. Monthly and daily Aquarius-retrieved SSS data Level-3 (Official Version 3.0) with spatial resolution are compared with local SSS in DTNP obtained from Water Quality Monitoring Project for the Florida Keys National Marine Sanctuary and southwest Florida shelf, which includes DTNP, for the concurrent interval from 2011-2014. Our statistical analysis shows a satisfactory agreement between daily Aquarius SSS and local SSS (r2=0.68; RMSE=0.24 psu). Additional SSS data are obtained from the National Data Buoy Center DRYF1 station in DTNP. Monthly-simulated SSS (Global Ocean Physics Reanalysis GLORYS2V3) obtained from the MyOcean WebPortal compares relatively well with DRYF1 monthly SSS data (r2=0.68; RMSE=0.35 psu) for the earlier interval from 1998-2002. Our analysis indicates that Aquarius-retrieved and simulated SSS can be utilized as a substitute for local SSS in bivariate forward models to calculate pseudocoral δ18Ocoral as well as forward models other marine carbonates for locations without SSS observations.

Craton destruction by subduction, collision or plume impingement? Comparisons of some representative cratons in the world

NASA Astrophysics Data System (ADS)

Wang, Zhensheng; Kusky, Timothy; Li, Xiaoyong; Wang, Xu; Fu, Jianmin; Yuan, Yuefeng; Zhu, Peimin

2015-04-01

The fact that cratonic lithosphere can be destructed has been demonstrated by numerous studies. However, the driving force of craton destruction and its mechanism are still unclear1,2. Subduction, collision and mantle plumes, the most important driving forces for most geological events, may also be responsible for craton destruction. However, their relationship in the destruction process including which of them is the major driving force and how they interact with each other is not understood sufficiently1,2. In this article, the North China Craton, North Atlantic Craton, Tanzania Craton, Wyoming Craton, Kaapvaal Craton, Yangtze Craton, Yilgarn Craton and Superior Craton are used as examples to study their difference and similarities during subduction, collision, or mantle plume impingement. The work is mainly based on comparison of their tectonic history, geophysical data, as well as xenolith chronology. It is suggested that large-scale craton destruction can be influenced by the interaction of subduction, collision and mantle plumes, acting to different degrees in different examples. Mantle plume related thermal action enhances the chemical stratification or layering of subcontinental lithospheric mantle (SCLM), which can form a weak-coupling mid lithosphere discontinuity (MLD) 3,4,5 and a lower denser SCLM below the MLD. Convergence (subduction and collision), especially when associated with slab rollback 6, leads to the regional thinning of the cratonic margin, which is subsequently linked by extension (mantle plume or slab rollback) related discontinuities. Continuous extension-related discontinuities extend upward to the MLD depth and cut off the shearing resistance from adjacent blocks. Next, the lower part of the chemically stratified SCLM in the cratonic interior is decoupled along the weakly coupled MLD and founders into the deep asthenosphere 7. Then the destruction of the rest of the lithosphere can be affected by upwelling related decompression melting and subduction related hydroweakening. Additionally, if the craton is surrounded by orogenic (mobile) belts, these, can absorb tectonic energy from collisions, may be aid in the preservation of the cratonic root 8. Kusky T., et al. (2007). Geological Society, London, Special Publications, 280(1): 331-343. Gao, S., et al. (2009). Chinese Science Bulletin, 54(19): 3367-3378. Thybo H., et al. (1997). Science, 275(5306): 1626-1629. Thybo H. (2006). Tectonophysics, 416(1): 53-79. Rader E. Et al. (2013). AGU Fall Meeting Abstracts, 2013, 8. Kusky T., et al. (2014). Tectonophysics, 3(630): 208-221. Chen L., et al. (2014). Geology, 42(3): 223-226. Lenardic, A. et al. (2000). Geophysical Research Letters, 27(8): 1235-1238.

The newly-discovered Late Cretaceous igneous rocks in the Nuocang district: Products of ancient crust melting trigged by Neo-Tethyan slab rollback in the western Gangdese

NASA Astrophysics Data System (ADS)

Jiang, Jun-Sheng; Zheng, You-Ye; Gao, Shun-Bao; Zhang, Yong-Chao; Huang, Jian; Liu, Jun; Wu, Song; Xu, Jing; Huang, Liang-Liang

2018-05-01

The newly discovered polymetallic Nuocang Pb-Zn skarn deposit is located in the southern Lhasa subterrane, western Gangdese, Tibet. The orebodies occur primarily at the contact zone between the Angjie Formation and the Linzizong volcanic rocks of Dianzhong Formation (LDF) that are dominated by basaltic andesitic tuff and rhyolite. Zircon U-Pb dating for two granite porphyries yield ages of 72.4 ± 0.2 Ma and 73.4 ± 0.9 Ma, which are different from the ages ( 69-60 Ma) of the LDF in the eastern Gangdese. The basaltic andesite tuff at Nuocang exhibits enrichment of MgO, TiO2, LILE, and LREE, with a relative depletion of SiO2, K2O, HFSE, and HREE, low Sr/Y ratios (32.9-38.0), and weak negative Eu anomalies (mean 0.86). They have 87Sr/86Sr(i) from 0.70695 to 0.70807 and εNd(t) values between -4.3 and -5.9. These features are similar to the Linzizong volcanic rocks of Dianzhong Formation in the Linzhou basin, indicating that they were associated with partial melting of mantle wedge mixing with 25-35% ancient Lhasa terrane basement. The rhyolite and granite porphyry show high SiO2 and K2O, and low Sr/Y ratio (1.2-9.9), enrichment of LILE and LREE and strong depletion of the HFSEs. They have pronounced negative Eu anomalies (mean 0.46), and εHf (t) values of the granite porphyry zircons range from -22.0 to -6.0. All these features suggest that they are the product of anatexis of ancient crustal materials heated by mantle-derived magma, the latter derived from Neo-Tethyan slab dehydration mechanisms. Combined with the previous geochronological and geochemical data, we proposed that the Nuocang district of western Gangdese in the southern Lhasa subterrane contains an ancient block, and the igneous rocks here were triggered by the Neo-Tethyan slab rollback starting at 82 Ma. The western Gangdese contains more ancient continental crustal materials and Late Cretaceous-Eocene Linzizong volcanic rocks and coeval intrusions than in the eastern Gangdese. Thus the western Gangdese block displays greater potential for deposits associated with Late Cretaceous-Eocene magmatism including porphyry Mo, polymetallic skarn (W-Sn-Mo-Pb-Zn-Ag), base and precious metal epithermal (Pb-Zn-Ag-Au), cryptoexplosive breccia (Pb-Zn-Ag), and hydrothermal vein Pb-Zn-Ag deposits.

Linkage Disequilibrium Mapping in Domestic Dog Breeds Narrows the Progressive Rod-Cone Degeneration (prcd) Interval and Identifies Ancestral Disease Transmitting Chromosome

PubMed Central

Goldstein, Orly; Zangerl, Barbara; Pearce-Kelling, Sue; Sidjanin, Duska J.; Kijas, James W.; Felix, Jeanette; Acland, Gregory M; Aguirre, Gustavo D.

2014-01-01

Canine progressive rod-cone degeneration (prcd) is a retinal disease previously mapped to a broad, gene-rich centromeric region of canine chromosome 9. As allelic disorders are present in multiple breeds, we used linkage disequilibrium (LD) to narrow the ∼6.4 Mb interval candidate region. Multiple dog breeds, each representing genetically isolated populations, were typed for SNPs and other polymorphisms identified from BACs. The candidate region was initially localized to a 1.5 Mb zero recombination interval between growth factor receptor-bound protein 2 (GRB2) and SEC14-like 1 (SEC14L). A fine-scale haplotype of the region was developed which reduced the LD interval to 106 Kb, and identified a conserved haplotype of 98 polymorphisms present in all prcd-affected chromosomes from 14 different dog breeds. The findings strongly suggest that a common ancestor transmitted the prcd disease allele to many of the modern dog breeds, and demonstrate the power of LD approach in the canine model. PMID:16859891

Biomorphic networks: approach to invariant feature extraction and segmentation for ATR

NASA Astrophysics Data System (ADS)

Baek, Andrew; Farhat, Nabil H.

1998-10-01

Invariant features in two dimensional binary images are extracted in a single layer network of locally coupled spiking (pulsating) model neurons with prescribed synapto-dendritic response. The feature vector for an image is represented as invariant structure in the aggregate histogram of interspike intervals obtained by computing time intervals between successive spikes produced from each neuron over a given period of time and combining such intervals from all neurons in the network into a histogram. Simulation results show that the feature vectors are more pattern-specific and invariant under translation, rotation, and change in scale or intensity than achieved in earlier work. We also describe an application of such networks to segmentation of line (edge-enhanced or silhouette) images. The biomorphic spiking network's capabilities in segmentation and invariant feature extraction may prove to be, when they are combined, valuable in Automated Target Recognition (ATR) and other automated object recognition systems.

Relationship Between Maximum Tsunami Amplitude and Duration of Signal

NASA Astrophysics Data System (ADS)

Kim, Yoo Yin; Whitmore, Paul M.

2014-12-01

All available tsunami observations at tide gauges situated along the North American coast were examined to determine if there is any clear relationship between maximum amplitude and signal duration. In total, 89 historical tsunami recordings generated by 13 major earthquakes between 1952 and 2011 were investigated. Tidal variations were filtered out of the signal and the duration between the arrival time and the time at which the signals drops and stays below 0.3 m amplitude was computed. The processed tsunami time series were evaluated and a linear least-squares fit with a 95 % confidence interval was examined to compare tsunami durations with maximum tsunami amplitude in the study region. The confidence interval is roughly 20 h over the range of maximum tsunami amplitudes in which we are interested. This relatively large confidence interval likely results from variations in local resonance effects, late-arriving reflections, and other effects.

[Evaluation of immunogenicity and safety of 2 immunizations with allantoic intranasal live influenza vaccine Ultragrivac].

PubMed

Shishkina, L N; Mazurkova, N A; Ternovoĭ, V A; Bulychev, L E; Tumanov, Iu V; Skarnovich, M O; Kabanov, A S; Ryndiuk, N N; Kuzubov, V I; Mironov, A N; Stavskiĭ, E A; Drozdov, I G

2011-01-01

Evaluate reactogenicity, safety and immunogenicity in phase 2 clinical trials of 2 immunization schedules with Ultragrivac--an allantoic intranasal life influenza vaccine based on A/17/ duck/Potsdam/86/92 [17/H5] reassortant strain. 4 groups of volunteers participated in the study: group 1--40 individuals were vaccinated twice with a 10 day interval; group 2--40 individuals were vaccinated twice with a 21 day interval; group 3 (control)--10 individuals received placebo twice with a 10 day interval; group 4 (control)--10 individuals received placebo twice with a 21 day interval. Local (secretory IgA), cellular and humoral immune response were evaluated. Humoral immunity was evaluated by the intensity of increase of geometric mean antibody titers against 2 influenza virus strains A/17/duck/Potsdam/86/92 [17/H5] and A/chicken/Suzdalka/Nov-1 1/2005 (H5N1), and by the level of significant (4 times or more) antibody seroconversions after the vaccination. After the use of Ultragrivac the level of secretory IgA in the nasal cavity of vaccinated volunteers in the groups with revaccination intervals of 10 and 21 days increased significantly. The second immunization with 10 or 21 day intervals significantly increased postvaccinal humoral immune response. Humoral immune response induction after 2 vaccinations with 10 day interval was no less effective than with 21 day interval. Ultragrivac allantoic intranasal live influenza vaccine is areactogenic, harmless for vaccinated individuals, safe for those around, and has immunogenic properties against not only homologous virus A(H5N2), but also against influenza strain A(H5N1).

Aberrant Expression of the Cell Polarity Regulator aPKCλ/ι is Associated With Disease Progression in Cervical Intraepithelial Neoplasia (CIN): A Possible Marker for Predicting CIN Prognosis.

PubMed

Mizushima, Taichi; Asai-Sato, Mikiko; Akimoto, Kazunori; Nagashima, Yoji; Taguri, Masataka; Sasaki, Kazunori; Nakaya, Masa-aki; Asano, Ryoko; Tokinaga, Aya; Kiyono, Tohru; Hirahara, Fumiki; Ohno, Shigeo; Miyagi, Etsuko

2016-03-01

Atypical protein kinase C λ/ι (aPKCλ/ι) is a regulator of epithelial cellular polarity. It is also overexpressed in several cancers and functions in cell proliferation and invasion. Therefore, we hypothesized that aPKCλ/ι may be involved in development and progression of cervical intraepithelial neoplasia (CIN), the precancerous disease of cervical cancer induced by human papillomavirus. To do this, we investigated the relationship between aPKCλ/ι expression and CIN. aPKCλ/ι expression level and subcellular localization were assessed in 192 CIN biopsy samples and 13 normal epithelial samples using immunohistochemistry. aPKCλ/ι overexpression (normal epithelium, 7.7%; CIN1, 41.7%; CIN2/3, 76.4%) and aPKCλ/ι nuclear localization (normal epithelium, 0.0%; CIN1, 36.9%; CIN2/3, 78.7%) were higher in CIN samples than normal samples (P<0.05), suggesting that CIN grade is related to aPKCλ/ι overexpression and nuclear localization. Then, 140 CIN cases were retrospectively analyzed for 4-yr cumulative disease progression and regression rates using the Cox proportional hazards model. CIN1 cases with aPKCλ/ι overexpression or aPKCλ/ι nuclear localization had a higher progression rate than CIN1 cases with normal aPKCλ/ι expression levels or cytoplasmic localization (62.5% vs. 9.7% and 63.1% vs. 9.4%, respectively; P<0.001). Multivariate analysis indicated that human papillomavirus types 16 and 18, aPKCλ/ι overexpression (hazard ratio=4.26; 95% confidence interval, 1.50-12.1; P=0.007), and aPKCλ/ι nuclear localization (hazard ratio=3.59; 95% confidence interval, 1.24-10.4; P=0.019) were independent risk factors for CIN1 progression. In conclusion, aPKCλ/ι could be useful for the therapeutic management of patients with CIN, particularly those with non-human papillomavirus 16/18 types.

Hemostatic efficacy of local chitosan linear polymer granule in an experimental sheep model with severe bleeding of arteria and vena femoralis.

PubMed

Ersoy, Gürkan; Rodoplu, Ülkümen; Yılmaz, Osman; Gökmen, Necati; Doğan, Alper; Dikme, Özgür; Aydınoğlu, Aslı; Orhon, Okyanus

2016-05-01

The aim of the present study was to evaluate the hemostatic effect of chitosan linear polymer in a sheep model with femoral bleeding. Following induction of anesthesia and intubation of sheep, groin injury was induced to initiate hemorrhage. Animals were randomly assigned to study and control groups. In the control group, absorbent pads were packed on the wound, and pressure was supplied by a weight placed over the dressing. In the study group, chitosan linear polymer was poured onto the bleeding site; absorbent pads and pressure were applied in the same manner. At 5-min intervals, bleeding was evaluated. Primary endpoint was time to hemostasis. Bleeding had stopped by the 1st interval in 5 members of the study group, and by the 2nd interval in 1 member. One sheep was excluded. The bleeding stopped after the 1st interval in 1 member of the control group and after the 2nd interval in 4 members. Bleeding stopped in 2 cases following ligation of the bleeding vessel. Hemostasis was achieved earlier in the study group, compared to the control group, and the difference was statistically significant. Hemostasis was achieved earlier following application of chitosan linear polymer.

Likelihood of home death associated with local rates of home birth: influence of local area healthcare preferences on site of death.

PubMed

Silveira, Maria J; Copeland, Laurel A; Feudtner, Chris

2006-07-01

We tested whether local cultural and social values regarding the use of health care are associated with the likelihood of home death, using variation in local rates of home births as a proxy for geographic variation in these values. For each of 351110 adult decedents in Washington state who died from 1989 through 1998, we calculated the home birth rate in each zip code during the year of death and then used multivariate regression modeling to estimate the relation between the likelihood of home death and the local rate of home births. Individuals residing in local areas with higher home birth rates had greater adjusted likelihood of dying at home (odds ratio [OR]=1.04 for each percentage point increase in home birth rate; 95% confidence interval [CI] = 1.03, 1.05). Moreover, the likelihood of dying at home increased with local wealth (OR=1.04 per $10000; 95% CI=1.02, 1.06) but decreased with local hospital bed availability (OR=0.96 per 1000 beds; 95% CI=0.95, 0.97). The likelihood of home death is associated with local rates of home births, suggesting the influence of health care use preferences.

Establishment of reference intervals for plasma protein electrophoresis in Indo-Pacific green sea turtles, Chelonia mydas.

PubMed

Flint, Mark; Matthews, Beren J; Limpus, Colin J; Mills, Paul C

2015-01-01

Biochemical and haematological parameters are increasingly used to diagnose disease in green sea turtles. Specific clinical pathology tools, such as plasma protein electrophoresis analysis, are now being used more frequently to improve our ability to diagnose disease in the live animal. Plasma protein reference intervals were calculated from 55 clinically healthy green sea turtles using pulsed field electrophoresis to determine pre-albumin, albumin, α-, β- and γ-globulin concentrations. The estimated reference intervals were then compared with data profiles from clinically unhealthy turtles admitted to a local wildlife hospital to assess the validity of the derived intervals and identify the clinically useful plasma protein fractions. Eighty-six per cent {19 of 22 [95% confidence interval (CI) 65-97]} of clinically unhealthy turtles had values outside the derived reference intervals, including the following: total protein [six of 22 turtles or 27% (95% CI 11-50%)], pre-albumin [two of five, 40% (95% CI 5-85%)], albumin [13 of 22, 59% (95% CI 36-79%)], total albumin [13 of 22, 59% (95% CI 36-79%)], α- [10 of 22, 45% (95% CI 24-68%)], β- [two of 10, 20% (95% CI 3-56%)], γ- [one of 10, 10% (95% CI 0.3-45%)] and β-γ-globulin [one of 12, 8% (95% CI 0.2-38%)] and total globulin [five of 22, 23% (8-45%)]. Plasma protein electrophoresis shows promise as an accurate adjunct tool to identify a disease state in marine turtles. This study presents the first reference interval for plasma protein electrophoresis in the Indo-Pacific green sea turtle.

Incomplete surgery, local immunostimulation, and recurrence of some tumour types in dogs and cats.

PubMed

Misdorp, W

1987-07-01

Histologically confirmed inadequate treatment resulted in a lower than expected recurrence percentage in dogs with haemangiopericytoma (38%) and mastocytoma (30%). Clinical suspicion of inadequate tumour treatment did not always correlate with the histologically assessed inadequacy, nor with the appearance of local recurrence. Local recurrence did not seem to be correlated with histological grade of malignancy and tumour size. Local injection of C. parvum vaccine did not result in a lower percentage of local recurrence or longer recurrence-free intervals in any of the three tumour groups (canine haemangiopericytoma, canine mastocytoma, feline mammary carcinoma). Nor was palliative local adjuvant injection of Cp successful in dogs and cats with soft tissue sarcomas or in dogs with gingival melanoma. Re-operation of locally recurrent tumour was successful in some dogs with haemangiopericytoma, in a few with mastocytoma, but not in cats with mammary carcinoma. A trend toward histological progression of recurrences and metastases, when compared with the primary tumours, was not evident. The possible reasons for the relatively low recurrence rate of some tumour types and for the failure of Cp-treatment are discussed.

Paleohydrology and paleoenvironments at Bir Sahara: Pleistocene lithostratigraphy and sedimentology in the southern Egyptian Sahara

NASA Astrophysics Data System (ADS)

Hill, Christopher L.; Schild, Romuald

2017-12-01

The Bir Sahara area contains a remarkable record of Middle and Late Pleistocene hydrologic and environmental conditions for Saharan North Africa, based on lithostratigraphic and sedimentologic evidence from basin-fill deposits. Some of the deposits contain Lower Paleolithic (Acheulean) or Middle Paleolithic artifacts that help to constrain their age, since Acheulian artifacts are assigned to the Middle Pleistocene, while Middle Paleolithic artifacts are limited to either the Middle or Late Pleistocene. Locality BS-14 is in the southern part of Bir Sahara, while localities E-88-15, E-88-2, BS-13, and BS-16 are situated in the south-central part of the deflational basin, closer to the present-day water-hole. Lowered groundwater conditions during arid intervals resulted in erosional topographic basins. These deflational basins were later filled with sediments associated with wetter hydrologic conditions. The oldest studied sedimentary sequence in the Bir Sahara depression (BS-14) contains in situ Acheulian artifacts. Acheulian handaxes are found in sands underlying carbonates that are interpreted as evidence of spring-fed pond and marsh environments during a Middle Pleistocene wet interval. At the E-88-15 locality, the stratigraphic sequence documents deposition in a possible perennial pond or small lake that varied in extent and depth and is associated with Middle Paleolithic artifacts. At E-88-12 and BS-13, lateral and vertical variations in the lithofacies of the basin-fill sediments provide additional records of changing hydrologic conditions during the Late Pleistocene. These hydrologic conditions appear to reflect variations in water-table levels related to groundwater recharge and, at times, local rains.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nemani, Deepika; Vapiwala, Neha; Hwang, W.-T.

Purpose: Little information has been reported regarding outcomes after treatment for patients with early-stage invasive breast cancer and a prior nonbreast malignancy. This report analyzes the outcomes in patients with Stage I and II breast cancer after breast conservation treatment (BCT) with a prior nonbreast malignancy. Methods and Materials: The study cohort comprised 66 women with invasive breast cancer and a prior nonbreast malignancy. All patients were treated with breast conservation surgery followed by definitive breast irradiation between 1978 and 2003. Median ages at diagnosis of invasive breast cancer and prior malignancy were 57 and 50 years, respectively. The medianmore » interval between the prior malignancy and breast cancer was 7.0 years. Median and mean follow-up times after BCT were 5.3 and 7.0 years. Results: The 5-year and 10-year overall survival rates were 94% (95% confidence interval [CI], 82-98%) and 78% (95% CI, 59-89%), respectively. There were 4 patients (6%) with local failure and 10 patients (15%) with distant metastases. The 10-year rate of local failure rate was 5% (95% CI, 2-16%) and freedom from distant metastases was 78% (95% CI, 61-88%). No obvious differences in survival or local control were noted compared with the reported results in the literature for patients with invasive breast cancer alone. Conclusions: Both overall survival and local control at 5 and 10 years were comparable to rates observed in early-stage breast cancer patients without a prior malignancy. Prior nonbreast malignancy is not a contraindication to BCT, if the primary cancer is effectively controlled.« less

Aspen's ecological role in the West

Treesearch

William H. Romme; Lisa Floyd-Hanna; David D. Hanna; Elisabeth Bartlett

2001-01-01

Aspen exhibits a variety of ecological roles. In southern Colorado, the 1880 landscape mosaic contained a range of stand ages, of which half were >70 years old and half were younger. Pure aspen stands in southern Colorado are widespread and may result from previous short fire intervals that eliminated local conifer seed sources. Aspen regeneration in northern...

47 CFR 52.35 - Porting Intervals.

Code of Federal Regulations, 2012 CFR

2012-10-01

... telephone numbers must complete a simple wireline-to-wireline or simple intermodal port request within one... work week of Monday through Friday represents mandatory business days and 8 a.m. to 5 p.m. represents... complete Local Service Request (LSR) must be received by the current service provider between 8 a.m. and 1...

47 CFR 52.35 - Porting Intervals.

Code of Federal Regulations, 2013 CFR

2013-10-01

... telephone numbers must complete a simple wireline-to-wireline or simple intermodal port request within one... work week of Monday through Friday represents mandatory business days and 8 a.m. to 5 p.m. represents... complete Local Service Request (LSR) must be received by the current service provider between 8 a.m. and 1...

Pleomorphic liposarcoma following radiotherapy for breast carcinoma

DOE Office of Scientific and Technical Information (OSTI.GOV)

Arbabi, L.; Warhol, M.J.

1982-03-01

A pleomorphic liposarcoma arising in a site previously irradiated as a treatment for breast carcinoma is described. This case fulfills the criteria for a tumor to be radiation-induced. The tumor is localized with an irradiated area, there is a clear histologic distinction between the previous and current tumor, and there is a long latent interval.

75 FR 5013 - Local Number Portability Porting Interval and Validation Requirements; Telephone Number Portability

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-01

... proposals submitted to the Commission regarding what data fields are necessary in order to complete simple...), and other interested parties on or before April 2, 2010. ADDRESSES: You may submit comments... information fields are necessary for completing simple ports. On November 2, 2009, the North American...

Bidirectional holographic codes and sub-AdS locality

NASA Astrophysics Data System (ADS)

Yang, Zhao; Hayden, Patrick; Qi, Xiaoliang

Tensor networks implementing quantum error correcting codes have recently been used as toy models of the holographic duality which explicitly realize some of the more puzzling features of the AdS/CFT correspondence. These models reproduce the Ryu-Takayanagi entropy formula for boundary intervals, and allow bulk operators to be mapped to the boundary in a redundant fashion. These exactly solvable, explicit models have provided valuable insight but nonetheless suffer from many deficiencies, some of which we attempt to address in this talk. We propose a new class of tensor network models that subsume the earlier advances and, in addition, incorporate additional features of holographic duality, including: (1) a holographic interpretation of all boundary states, not just those in a ''code'' subspace, (2) a set of bulk states playing the role of ''classical geometries'' which reproduce the Ryu-Takayanagi formula for boundary intervals, (3) a bulk gauge symmetry analogous to diffeomorphism invariance in gravitational theories, (4) emergent bulk locality for sufficiently sparse excitations, and the ability to describe geometry at sub-AdS resolutions or even flat space. David and Lucile Packard Foundation.

Bidirectional holographic codes and sub-AdS locality

NASA Astrophysics Data System (ADS)

Yang, Zhao; Hayden, Patrick; Qi, Xiao-Liang

2016-01-01

Tensor networks implementing quantum error correcting codes have recently been used to construct toy models of holographic duality explicitly realizing some of the more puzzling features of the AdS/CFT correspondence. These models reproduce the Ryu-Takayanagi entropy formula for boundary intervals, and allow bulk operators to be mapped to the boundary in a redundant fashion. These exactly solvable, explicit models have provided valuable insight but nonetheless suffer from many deficiencies, some of which we attempt to address in this article. We propose a new class of tensor network models that subsume the earlier advances and, in addition, incorporate additional features of holographic duality, including: (1) a holographic interpretation of all boundary states, not just those in a "code" subspace, (2) a set of bulk states playing the role of "classical geometries" which reproduce the Ryu-Takayanagi formula for boundary intervals, (3) a bulk gauge symmetry analogous to diffeomorphism invariance in gravitational theories, (4) emergent bulk locality for sufficiently sparse excitations, and (5) the ability to describe geometry at sub-AdS resolutions or even flat space.

Intermittent carbonate sedimentation in the equatoral Indian Ocean: fluctuations of the Eocene CCD?

NASA Astrophysics Data System (ADS)

Mitchison, F.; Kachovich, S.; Backman, J.; Pike, J.

2017-12-01

IODP Expedition 362 recently drilled from the sea floor to oceanic basement in the eastern equatorial Indian Ocean at Site U1480G (3°N, 91°E, water depth 4148 m). Beneath the thick ( 1250 m) predominantly siliciclastic Nicobar Fan succession, a condensed ( 10 m) middle Eocene pelagic interval displayed striking decimetre-scale banding, alternating between calcareous oozes and darker clays. We investigate whether deposition of the calcareous sediments was associated with periodic global carbonate accumulation events previously documented in the Equatorial Pacific and Atlantic Oceans, linked to oscillations of the carbonate compensation depth (CCD). We present high-resolution geochemical records (carbonate, organic carbon, bulk carbonate stable isotopes) and scanning electron microscope micro-element maps through several of the calcareous to clay transitions, as well as microfossil assemblages and new biostratigraphic constraints for the interval. Our data will reveal whether the banded sediments represent fluctuations of the CCD, and whether the CCD was likely responding to global (e.g. changes in pCO2) or local (e.g. local changes in calcareous plankton productivity) processes.

Contamination of the 5394 Å spectral region by telluric lines

NASA Astrophysics Data System (ADS)

Vince, I.; Vince, O.

2010-11-01

The spectral region in the vicinity of 5394 Å contains three prominent photospheric spectral lines, which can be used as a solar plasma diagnostic tool. The occurrence of telluric lines in this region is a potential source of systematic and random errors in these solar spectral lines. The goal of our investigation was to determine the telluric line contamination of this interesting spectral region. Several series of high-resolution solar spectra within an interval of about 4 Å around the 5394 Å wavelength were observed at different zenith distances of the Sun. Comparison of these spectra has permitted identification of telluric lines in this spectral interval. The observations were carried out with the horizontal solar spectrograph of the Heliophysical Observatory in Debrecen. Telluric feature blending was identified in the blue and red wings of the Fe I 5393.2 Å line, and in the local continuum of the Mn I 5394.7 Å line. The blue wing of the Fe I 5395.2 Å line is contaminated by a weak telluric feature too. The red continuum of this line has a more prominent telluric contamination. A dozen of water vapor telluric lines that determined the observed telluric features were identified in this spectral interval. The profiles of three telluric lines that have a significant influence on both the profiles of solar spectral lines and the level of local continuum were derived, and the variation of their parameters (equivalent width and central depth) with air mass were analyzed.

Properties of Asymmetric Detrended Fluctuation Analysis in the time series of RR intervals

NASA Astrophysics Data System (ADS)

Piskorski, J.; Kosmider, M.; Mieszkowski, D.; Krauze, T.; Wykretowicz, A.; Guzik, P.

2018-02-01

Heart rate asymmetry is a phenomenon by which the accelerations and decelerations of heart rate behave differently, and this difference is consistent and unidirectional, i.e. in most of the analyzed recordings the inequalities have the same directions. So far, it has been established for variance and runs based types of descriptors of RR intervals time series. In this paper we apply the newly developed method of Asymmetric Detrended Fluctuation Analysis, which so far has mainly been used with economic time series, to the set of 420 stationary 30 min time series of RR intervals from young, healthy individuals aged between 20 and 40. This asymmetric approach introduces separate scaling exponents for rising and falling trends. We systematically study the presence of asymmetry in both global and local versions of this method. In this study global means "applying to the whole time series" and local means "applying to windows jumping along the recording". It is found that the correlation structure of the fluctuations left over after detrending in physiological time series shows strong asymmetric features in both magnitude, with α+ <α-, where α+ is related to heart rate decelerations and α- to heart rate accelerations, and the proportion of the signal in which the above inequality holds. A very similar effect is observed if asymmetric noise is added to a symmetric self-affine function. No such phenomena are observed in the same physiological data after shuffling or with a group of symmetric synthetic time series.

Flood of September 7-9, 1987, in Lexington and Richland counties in the vicinity of Saint Andrews Road and Irmo, South Carolina

USGS Publications Warehouse

Guimaraes, W.B.

1989-01-01

Localized heavy rainfall on September 7, 1987, in Lexington and Richland Counties, South Carolina, caused severe flooding in the basins of Kinley Creek, Rawls Creek, and Stoop Creek, in the vicinity of Saint Andrews Road and the town of Irmo, South Carolina. The flooding damaged homes, furnishings, and landscaping. Rainfall, peak discharges, high-water elevations, and frequency relations of rainfall and discharge are tabulated and plotted for selected streams. The rain was most intense in the area along Rawls Creek, R-2 (tributary to Rawls Creek), Koon Branch (tributary to Rawls Creek), and the upper part of Kinley Creek. A rainfall of about 5.5 inches in 3 hours, which has a recurrence interval in excess of 100 years, was reported by local residents along these streams. High-water marks are presented in this report for Stoop Creek, Kinley Creek, K-1 (tributary to Kinley Creek), K-2 (tributary to Kinley Creek), unnamed tributary to Kinley Creek, Lowery Creek (tributary to Kinley Creek), Rawls Creek, R-2 (tributary to Rawls Creek), and Koon Branch (tributary to Rawls Creek). Peak discharges at the most downstream sites on Rawls Creek and Koon Branch had recurrence intervals of 75 years and 60 years, respectively. Peak discharges on Kinley Creek varied from 20 to 25 years north of K-1 basin to less than 10 years at K-1. The Stoop Creek basin had a recurrence interval of 10 years. (USGS)

Interval From Imaging to Treatment Delivery in the Radiation Surgery Age: How Long Is Too Long?

DOE Office of Scientific and Technical Information (OSTI.GOV)

Seymour, Zachary A., E-mail: seymourz@radonc.ucsf.edu; Fogh, Shannon E.; Westcott, Sarah K.

Purpose: The purpose of this study was to evaluate workflow and patient outcomes related to frameless stereotactic radiation surgery (SRS) for brain metastases. Methods and Materials: We reviewed all treatment demographics, clinical outcomes, and workflow timing, including time from magnetic resonance imaging (MRI), computed tomography (CT) simulation, insurance authorization, and consultation to the start of SRS for brain metastases. Results: A total of 82 patients with 151 brain metastases treated with SRS were evaluated. The median times from consultation, insurance authorization, CT simulation, and MRI for treatment planning were 15, 7, 6, and 11 days to SRS. Local freedom from progressionmore » (LFFP) was lower in metastases with MRI ≥14 days before treatment (P=.0003, log rank). The 6- and 12-month LFFP rate were 95% and 75% for metastasis with interval of <14 days from MRI to treatment compared to 56% and 34% for metastases with MRI ≥14 days before treatment. On multivariate analysis, LFFP remained significantly lower for lesions with MRI ≥14 days at SRS (P=.002, Cox proportional hazards; hazard ratio: 3.4, 95% confidence interval: 1.6-7.3). Conclusions: Delay from MRI to SRS treatment delivery for brain metastases appears to reduce local control. Future studies should monitor the timing from imaging acquisition to treatment delivery. Our experience suggests that the time from MRI to treatment should be <14 days.« less

A MIS 15-MIS 12 record of environmental changes and Lower Palaeolithic occupation from Valle Giumentina, central Italy

NASA Astrophysics Data System (ADS)

Villa, Valentina; Pereira, Alison; Chaussé, Christine; Nomade, Sébastien; Giaccio, Biagio; Limondin-Lozouet, Nicole; Fusco, Fabio; Regattieri, Eleonora; Degeai, Jean-Philippe; Robert, Vincent; Kuzucuoglu, Catherine; Boschian, Giovanni; Agostini, Silvano; Aureli, Daniele; Pagli, Marina; Bahain, Jean Jacques; Nicoud, Elisa

2016-11-01

An integrated geological study, including sedimentology, stable isotope analysis (δ18O, δ13C), geochemistry, micromorphology, biomarker analysis, 40Ar/39Ar geochronology and tephrochronology, was undertaken on the Quaternary infill of the Valle Giumentina basin in Central Italy, which also includes an outstanding archaeological succession, composed of nine human occupation levels ascribed to the Lower and Middle Palaeolithic. 40Ar/39Ar dating, and other palaeoenvironmental and tephrochronological data, constrain the sedimentary history of the whole succession to the MIS 15-MIS 12 interval, between 618 ± 13 ka and 456 ± 2 ka. Palaeoenvironmental proxies suggest that over this time interval of about 150 ka, sedimentary and pedogenic processes were mainly influenced by climatic changes, in particular by the pulsing of local mountain glaciers of the Majella massif. Specifically, the Valle Giumentina succession records glacio-fluvial and lacustrine sedimentation during the colder glacial periods and pedogenesis and/or alluvial sedimentation during the warmer interglacial and/or interstadial periods. During this interval, tectonics played a negligible role as a driving factor of local morphogenesis and sedimentation, whereas the general regional uplift experienced in the Middle Pleistocene led to capture of the basin and its definitive extinction after MIS 12. These data substantially improve previous knowledge of the chronology and sedimentary evolution of the succession, providing for the first time, a well constrained chronological and palaeoenvironmental framework for the archaeological and human palaeoecological record of Valle Giumentina.

Spatial variability in the trends in extreme storm surges and weekly-scale high water levels in the eastern Baltic Sea

NASA Astrophysics Data System (ADS)

Soomere, Tarmo; Pindsoo, Katri

2016-03-01

We address the possibilities of a separation of the overall increasing trend in maximum water levels of semi-enclosed water bodies into associated trends in the heights of local storm surges and basin-scale components of the water level based on recorded and modelled local water level time series. The test area is the Baltic Sea. Sequences of strong storms may substantially increase its water volume and raise the average sea level by almost 1 m for a few weeks. Such events are singled out from the water level time series using a weekly-scale average. The trends in the annual maxima of the weekly average have an almost constant value along the entire eastern Baltic Sea coast for averaging intervals longer than 4 days. Their slopes are ~4 cm/decade for 8-day running average and decrease with an increase of the averaging interval. The trends for maxima of local storm surge heights represent almost the entire spatial variability in the water level maxima. Their slopes vary from almost zero for the open Baltic Proper coast up to 5-7 cm/decade in the eastern Gulf of Finland and Gulf of Riga. This pattern suggests that an increase in wind speed in strong storms is unlikely in this area but storm duration may have increased and wind direction may have rotated.

Is there a relationship between gluten sensitivity and postural tachycardia syndrome?

PubMed

Penny, Hugo A; Aziz, Imran; Ferrar, Melloney; Atkinson, Jayne; Hoggard, Nigel; Hadjivassiliou, Marios; West, John N; Sanders, David S

2016-12-01

We have noticed that patients with postural tachycardia syndrome (PoTS) were placing themselves on a gluten-free diet without medical consultation. Therefore, we aimed to evaluate the prevalence of coeliac disease and self-reported gluten sensitivity in a cohort of patients with PoTS and compare this with local population data. A total of 100 patients with PoTS were recruited to complete a questionnaire that screened for gluten sensitivity, related symptoms and dietary habits. Patients were also assessed for coeliac disease. For comparison, the local coeliac prevalence was determined from a total of 1200 controls (group 1) and a further 400 controls (group 2), frequency matched for age and sex, who completed the same questionnaire. Overall, 4/100 (4%) patients with PoTS had serology and biopsy-proven coeliac disease. This was significantly higher than the local population prevalence of coeliac disease (12/1200, 1%; odds ratio: 4.1, 95% confidence interval: 1.3-13.0; P=0.03). PoTS patients also had a higher prevalence of self-reported gluten sensitivity (42 vs. 19%, respectively; odds ratio: 3.1, 95% confidence interval: 2.0-5.0; P<0.0001) compared with age-matched and sex-matched controls. This is the first study to suggest a potential association between gluten-related disorders and PoTS. A prospective study evaluating this relationship further may enable a better understanding and management of these conditions.

Salvage HDR Brachytherapy for Recurrent Prostate Cancer After Previous Definitive Radiation Therapy: 5-Year Outcomes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, Chien Peter; Weinberg, Vivian; Shinohara, Katsuto

Purpose: Evaluate efficacy and toxicity of salvage high-dose-rate brachytherapy (HDRB) for locally recurrent prostate cancer after definitive radiation therapy (RT). Methods and Materials: We retrospectively analyzed 52 consecutively accrued patients undergoing salvage HDRB between 1998 and 2009 for locally recurrent prostate cancer after previous definitive RT. After pathologic confirmation of locally recurrent disease, patients received 36 Gy in 6 fractions. Twenty-four patients received neoadjuvant hormonal therapy before salvage, and no patients received adjuvant hormonal therapy. Determination of biochemical failure after salvage HDRB was based on the Phoenix definition. Overall survival (OS) and bF distributions were calculated using the Kaplan-Meier method.more » Univariate analyses were performed to identify predictors of biochemical control. Acute and late genitourinary (GU) and gastrointestinal (GI) toxicities, based on Common Terminology Criteria for Adverse Events (version 4), were documented. Results: Median follow-up after salvage HDRB was 59.6 months. The 5-year OS estimate was 92% (95% confidence interval [CI]: 80%-97%) with median survival not yet reached. Five-year biochemical control after salvage was 51% (95% CI: 34%-66%). Median PSA nadir postsalvage was 0.1 (range: 0-7.2) reached at a median of 10.2 months after completing HDRB. As for complications, acute and late grade 3 GU toxicities were observed in only 2% and 2%, respectively. No grade 2 or higher acute GI events and 4% grade 2 GI late events were observed. On univariate analysis, disease-free interval after initial definitive RT (P=.07), percent of positive cores at the time of diagnosis (P=.08), interval from first recurrence to salvage HDRB (P=.09), and pre-HDRB prostate-specific antigen (P=.07) were each of borderline significance in predicting biochemical control after salvage HDRB. Conclusions: Prostate HDRB is an effective salvage modality with relatively few long-term toxicities. We provide potential predictors of biochemical control for prostate salvage HDRB.« less

Posterior interosseous nerve localization within the proximal forearm - a patient normalized parameter.

PubMed

Kamineni, Srinath; Norgren, Crystal R; Davidson, Evan M; Kamineni, Ellora P; Deane, Andrew S

2017-04-18

To provide a "patient-normalized" parameter in the proximal forearm. Sixty-three cadaveric upper extremities from thirty-five cadavers were studied. A muscle splitting approach was utilized to locate the posterior interosseous nerve (PIN) at the point where it emerges from beneath the supinator. The supinator was carefully incised to expose the midpoint length of the nerve as it passes into the forearm while preserving the associated fascial connections, thereby preserving the relationship of the nerve with the muscle. We measured the transepicondylar distance (TED), PIN distance in the forearm's neutral rotation position, pronation position, supination position, and the nerve width. Two individuals performed measurements using a digital caliper with inter-observer and intra-observer blinding. The results were analyzed with the Wilcoxon-Mann-Whitney test for paired samples. In pronation, the PIN was within two confidence intervals of 1.0 TED in 95% of cases (range 0.7-1.3 TED); in neutral, within two confidence intervals of 0.84 TED in 95% of cases (range 0.5-1.1 TED); in supination, within two confidence intervals of 0.72 TED in 95% of cases (range 0.5-0.9 TED). The mean PIN distance from the lateral epicondyle was 100% of TED in a pronated forearm, 84% in neutral, and 72% in supination. Predictive accuracy was highest in supination; in all cases the majority of specimens (90.47%-95.23%) are within 2 cm of the forearm position-specific percentage of TED. When comparing right to left sides for TEDs with the signed Wilcoxon-Mann-Whitney test for paired samples as well as a significance test (with normal distribution), the P -value was 0.0357 (significance - 0.05) indicating a significant difference between the two sides. This "patient normalized" parameter localizes the PIN crossing a line drawn between the lateral epicondyle and the radial styloid. Accurate PIN localization will aid in diagnosis, injections, and surgical approaches.

Posterior interosseous nerve localization within the proximal forearm - a patient normalized parameter

PubMed Central

Kamineni, Srinath; Norgren, Crystal R; Davidson, Evan M; Kamineni, Ellora P; Deane, Andrew S

2017-01-01

AIM To provide a “patient-normalized” parameter in the proximal forearm. METHODS Sixty-three cadaveric upper extremities from thirty-five cadavers were studied. A muscle splitting approach was utilized to locate the posterior interosseous nerve (PIN) at the point where it emerges from beneath the supinator. The supinator was carefully incised to expose the midpoint length of the nerve as it passes into the forearm while preserving the associated fascial connections, thereby preserving the relationship of the nerve with the muscle. We measured the transepicondylar distance (TED), PIN distance in the forearm’s neutral rotation position, pronation position, supination position, and the nerve width. Two individuals performed measurements using a digital caliper with inter-observer and intra-observer blinding. The results were analyzed with the Wilcoxon-Mann-Whitney test for paired samples. RESULTS In pronation, the PIN was within two confidence intervals of 1.0 TED in 95% of cases (range 0.7-1.3 TED); in neutral, within two confidence intervals of 0.84 TED in 95% of cases (range 0.5-1.1 TED); in supination, within two confidence intervals of 0.72 TED in 95% of cases (range 0.5-0.9 TED). The mean PIN distance from the lateral epicondyle was 100% of TED in a pronated forearm, 84% in neutral, and 72% in supination. Predictive accuracy was highest in supination; in all cases the majority of specimens (90.47%-95.23%) are within 2 cm of the forearm position-specific percentage of TED. When comparing right to left sides for TEDs with the signed Wilcoxon-Mann-Whitney test for paired samples as well as a significance test (with normal distribution), the P-value was 0.0357 (significance - 0.05) indicating a significant difference between the two sides. CONCLUSION This “patient normalized” parameter localizes the PIN crossing a line drawn between the lateral epicondyle and the radial styloid. Accurate PIN localization will aid in diagnosis, injections, and surgical approaches. PMID:28473958

Increased tissue oxygenation explains the attenuation of hyperemia upon repetitive pneumatic compression of the lower leg.

PubMed

Messere, Alessandro; Ceravolo, Gianluca; Franco, Walter; Maffiodo, Daniela; Ferraresi, Carlo; Roatta, Silvestro

2017-12-01

The rapid hyperemia evoked by muscle compression is short lived and was recently shown to undergo a rapid decrease even in spite of continuing mechanical stimulation. The present study aims at investigating the mechanisms underlying this attenuation, which include local metabolic mechanisms, desensitization of mechanosensitive pathways, and reduced efficacy of the muscle pump. In 10 healthy subjects, short sequences of mechanical compressions ( n = 3-6; 150 mmHg) of the lower leg were delivered at different interstimulus intervals (ranging from 20 to 160 s) through a customized pneumatic device. Hemodynamic monitoring included near-infrared spectroscopy, detecting tissue oxygenation and blood volume in calf muscles, and simultaneous echo-Doppler measurement of arterial (superficial femoral artery) and venous (femoral vein) blood flow. The results indicate that 1 ) a long-lasting (>100 s) increase in local tissue oxygenation follows compression-induced hyperemia, 2 ) compression-induced hyperemia exhibits different patterns of attenuation depending on the interstimulus interval, 3 ) the amplitude of the hyperemia is not correlated with the amount of blood volume displaced by the compression, and 4 ) the extent of attenuation negatively correlates with tissue oxygenation ( r  = -0,78, P < 0.05). Increased tissue oxygenation appears to be the key factor for the attenuation of hyperemia upon repetitive compressive stimulation. Tissue oxygenation monitoring is suggested as a useful integration in medical treatments aimed at improving local circulation by repetitive tissue compression. NEW & NOTEWORTHY This study shows that 1 ) the hyperemia induced by muscle compression produces a long-lasting increase in tissue oxygenation, 2 ) the hyperemia produced by subsequent muscle compressions exhibits different patterns of attenuation at different interstimulus intervals, and 3 ) the extent of attenuation of the compression-induced hyperemia is proportional to the level of oxygenation achieved in the tissue. The results support the concept that tissue oxygenation is a key variable in blood flow regulation. Copyright © 2017 the American Physiological Society.

Love-to-Rayleigh Conversions and Seismic Anisotropy in Cascadia

NASA Astrophysics Data System (ADS)

Rieger, Duayne Matthew

Seismic anisotropy is often attributed to the development of lattice-preferred orientation (LPO) of olivine crystals in peridotite, induced by the dislocation creep component of mantle deformation (Karato et al., 2008; Ribe, 1992). Mantle-flow-induced seismic anisotropy is often modeled in the simple form of hexagonal symmetry, where the anisotropic volume is uniaxially fast or slow. This relationship between seismic anisotropy and mantle deformation allows for the mapping of mantle dynamics using measurements of seismic anisotropy. Presently, methods of measuring seismic anisotropy in Earth's mantle include shear-wave splitting and surface-wave tomography. These methods are tuned to seismically fast axes laying in the horizontal or surface-tangent plane and are limited in discerning clipping seismic fast axes. This is a shortcoming. It is reasonable to suspect the presence of dipping seismic fast axes induced by mantle flow in several tectonic regimes such as subduction zones. The slab rollback model of the subduction zone system has been argued to exhibit trench-parallel subslab anisotropy due to the lateral evacuation of the subslab mantle material (Hall et al., 2000; Russo and Silver, 1994). This model has been emboldened by the dominance of trench-parallel shear-wave-splitting measurements in the subslab mantle of global subduction zones. This model has significant geodynamic implications, requiring viscous decoupling between the subslab mantle and the sub-ducting slab. The Cascadian subduction zone is of particular scientific interest. While experiencing slab rollback (Zandt and Humphreys, 2008), trench-perpendicular shear-wave-splitting measurements are observed in the subslab mantle of Cascadia (Currie et al., 2004; Eakin et al., 2010; Long and Silver, 2008; 2009). This suggests either viscous coupling resulting in slab-entrained flow or the presence of an alternate relationship between finite strain in the mantle and seismic anisotropy. The ability to discern a clipping anisotropic axis would help gain insight into the mantle dynamics of regions such as Cascadia. Lateral gradients of seismic anisotropy in Earth's upper mantle induce coupling among Earth's spheroidal and toroidal normal modes. This coupling can manifest as observable surface-wave polarization anomalies resulting from Love to Rayleigh wave conversions. These Love to Rayleigh conversions are known in the literature as Quasi-Love (QL) waves (Park and Yu, 1992) and are sensitive to both the strike and the dip of an anisotropic symmetry axis. In this dissertation I investigate the phenomenology of QL surface-wave scattering, including its sensitivity to the type and orientation of seismic anisotropy. I then apply my findings to observations of QL wave scattering in Cascada in order to further constrain subslab mantle anisotropy in the region. First, I make initial observations and confirm the presence of QL scattering in Cascada and the western U.S. using data recorded on USArray. I then move on to develop an algorithm to model efficiently QL wave scattering in the presence of 3-dimensional anisotropic structure. Using this forward-modeling algorithm, I investigate the dependence of QL wave scattering on the type and orientation of seismic Anisotropy. I find that P and S anisotropies exhibit independent effects on scattering. Scattering due to S anisotropy is stronger than that due to P anisotropy for all orientations and dominates in the observed scattering pattern. Both the phase and amplitude of the QL wave is dependent on the orientation (strike and dip) of the symmetry axis relative to the incident propagation azimuth of the source-receiver great-circle path. Due to this, the orientation of the anisotropic symmetry axis provides a distinct signature which is observable in the variation of QL wave scattering with wave-propagation azimuth. Finally, using data recorded on USArray, I observe the variation in QL wave scattering with propagation azimuth. I then attempt to forward-model the observed behavior using the algorithm developed earlier. The best-fitting model suggests coherent trench-perpendicular mantle anisotropy with an eastward dip in the sublsab mantle of the Cascadian subduction zone. The resulting anisotropic model adds confidence to the entrained subslab mantle-flow model for Cascadia and further refutes the 3-D return-flow model associated with slab rollback.

Measured sections and discussion of the main turbidite member, Middle Pennsylvanian Minturn Formation, northern Sangre de Cristo Range, Custer and Saguache counties, Colorado

USGS Publications Warehouse

Soulliere, S.J.; DeAngelis, B.L.; Lindsey, D.A.

1984-01-01

The main turbidite member is the thickest and most extensive of the intervals of prodelta turbidites in the Minturn Formation. Each turbidite interval is part of a coarsening upward sequence interpreted as a prograding fan delta. A typical prograding cycle consists of prodelta marine shale and siltstone, prodelta turbidite sandstones, delta-front sandstone and conglomerate, and deltaic and alluvial-plain sandstone, siltstone, and shale. Fossils of 1and plants (mostly Calamites, including some in growth position) are locally abundant in deltaic and alluvial sediments of the prograding cycles. The turbidites are regarded as having been deposited offshore from alluvial systems.

A contour for the entanglement entropies in harmonic lattices

NASA Astrophysics Data System (ADS)

Coser, Andrea; De Nobili, Cristiano; Tonni, Erik

2017-08-01

We construct a contour function for the entanglement entropies in generic harmonic lattices. In one spatial dimension, numerical analysis are performed by considering harmonic chains with either periodic or Dirichlet boundary conditions. In the massless regime and for some configurations where the subsystem is a single interval, the numerical results for the contour function are compared to the inverse of the local weight function which multiplies the energy-momentum tensor in the corresponding entanglement hamiltonian, found through conformal field theory methods, and a good agreement is observed. A numerical analysis of the contour function for the entanglement entropy is performed also in a massless harmonic chain for a subsystem made by two disjoint intervals.

Localization of cortical tissue optical changes during seizure activity in vivo with optical coherence tomography

PubMed Central

Eberle, Melissa M.; Hsu, Mike S.; Rodriguez, Carissa L.; Szu, Jenny I.; Oliveira, Michael C.; Binder, Devin K.; Park, B. Hyle

2015-01-01

Optical coherence tomography (OCT) is a high resolution, minimally invasive imaging technique, which can produce depth-resolved cross-sectional images. In this study, OCT was used to detect changes in the optical properties of cortical tissue in vivo in mice during the induction of global (pentylenetetrazol) and focal (4-aminopyridine) seizures. Through the use of a confidence interval statistical method on depth-resolved volumes of attenuation coefficient, we demonstrated localization of regions exhibiting both significant positive and negative changes in attenuation coefficient, as well as differentiating between global and focal seizure propagation. PMID:26137382

Discrimination surfaces with application to region-specific brain asymmetry analysis.

PubMed

Martos, Gabriel; de Carvalho, Miguel

2018-05-20

Discrimination surfaces are here introduced as a diagnostic tool for localizing brain regions where discrimination between diseased and nondiseased participants is higher. To estimate discrimination surfaces, we introduce a Mann-Whitney type of statistic for random fields and present large-sample results characterizing its asymptotic behavior. Simulation results demonstrate that our estimator accurately recovers the true surface and corresponding interval of maximal discrimination. The empirical analysis suggests that in the anterior region of the brain, schizophrenic patients tend to present lower local asymmetry scores in comparison with participants in the control group. Copyright © 2018 John Wiley & Sons, Ltd.

IUE high resolution spectrophotometry of H Ly alpha emission from the local interstellar medium

NASA Technical Reports Server (NTRS)

Clarke, J. T.; Bowyer, S.; Fahr, H. J.; Lay, G.

1984-01-01

IUE high dispersion spectra of resonantly scattered solar Ly alpha emission from H moving into the solar system with the local interstellar wind are reported which are based on observations conducted in April 1981 and April 1983. A heliocentric velocity of -29 + or - 5 km/s has been observed from the ISW component along with a surface brightness which has decreased from about 1000 to 800 Rayleighs over the two-year interval. A preliminary derivation of the velocity of the ISM at large distances from the sun yields a value of 25.6 + or - 5 km/s.

Localized Scleroderma, Systemic Sclerosis and Cardiovascular Risk: A Danish Nationwide Cohort Study.

PubMed

Hesselvig, Jeanette Halskou; Kofoed, Kristian; Wu, Jashin J; Dreyer, Lene; Gislason, Gunnar; Ahlehoff, Ole

2018-03-13

Recent findings indicate that patients with systemic sclerosis have an increased risk of cardiovascular disease. To determine whether patients with systemic sclerosis or localized scleroderma are at increased risk of cardiovascular disease, a cohort study of the entire Danish population aged ≥ 18 and ≤ 100 years was conducted, followed from 1997 to 2011 by individual-level linkage of nationwide registries. Multivariable adjusted Cox regression models were used to estimate the hazard ratios (HRs) for a composite cardiovascular disease endpoint. A total of 697 patients with localized scleroderma and 1,962 patients with systemic sclerosis were identified and compared with 5,428,380 people in the reference population. In systemic sclerosis, the adjusted HR was 2.22 (95% confidence interval 1.99-2.48). No association was seen between patients with localized scleroderma and cardiovascular disease. In conclusion, systemic sclerosis is a significant cardiovascular disease risk factor, while patients with localized scleroderma are not at increased risk of cardiovascular disease.

Pragmatic and evidence-based approach to paediatric cerebrospinal fluid reference limits for white cell count and concentrations of total protein and glucose.

PubMed

Josman, Nicky; Tee, Nancy W S; Maiwald, Matthias; Loo, Liat Hui; Ho, Clement K M

2018-06-15

It is often impractical for each laboratory to establish its own paediatric reference intervals. This is particularly true for specimen types collected using invasive procedures, for example, cerebrospinal fluid (CSF). Published CSF reference intervals for white cell count, and concentrations of total protein and glucose were reviewed by stakeholders in a paediatric hospital. Consensus reference intervals for the three CSF parameters were then subjected to verification using guidelines from the Clinical Laboratory Standards Institute and residual CSF specimens. Consensus paediatric reference intervals adapted from published studies with minor modifications were locally verified as follows. White cell count (x10 6 cells/L): 0-20 (<1 month); 0-10 (1-2 months); 0-5 (>2 months). Total protein (g/L): 0.3-1.2 (<1 month); 0.2-0.6 (1-3 months); 0.1-0.4 (>3 months). Glucose (mmol/L): 2.0-5.6 (<6 months); 2.4-4.3 (6 months or older). © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Multi-Response Parameter Interval Sensitivity and Optimization for the Composite Tape Winding Process.

PubMed

Deng, Bo; Shi, Yaoyao; Yu, Tao; Kang, Chao; Zhao, Pan

2018-01-31

The composite tape winding process, which utilizes a tape winding machine and prepreg tapes, provides a promising way to improve the quality of composite products. Nevertheless, the process parameters of composite tape winding have crucial effects on the tensile strength and void content, which are closely related to the performances of the winding products. In this article, two different object values of winding products, including mechanical performance (tensile strength) and a physical property (void content), were respectively calculated. Thereafter, the paper presents an integrated methodology by combining multi-parameter relative sensitivity analysis and single-parameter sensitivity analysis to obtain the optimal intervals of the composite tape winding process. First, the global multi-parameter sensitivity analysis method was applied to investigate the sensitivity of each parameter in the tape winding processing. Then, the local single-parameter sensitivity analysis method was employed to calculate the sensitivity of a single parameter within the corresponding range. Finally, the stability and instability ranges of each parameter were distinguished. Meanwhile, the authors optimized the process parameter ranges and provided comprehensive optimized intervals of the winding parameters. The verification test validated that the optimized intervals of the process parameters were reliable and stable for winding products manufacturing.

Multi-Response Parameter Interval Sensitivity and Optimization for the Composite Tape Winding Process

PubMed Central

Yu, Tao; Kang, Chao; Zhao, Pan

2018-01-01

The composite tape winding process, which utilizes a tape winding machine and prepreg tapes, provides a promising way to improve the quality of composite products. Nevertheless, the process parameters of composite tape winding have crucial effects on the tensile strength and void content, which are closely related to the performances of the winding products. In this article, two different object values of winding products, including mechanical performance (tensile strength) and a physical property (void content), were respectively calculated. Thereafter, the paper presents an integrated methodology by combining multi-parameter relative sensitivity analysis and single-parameter sensitivity analysis to obtain the optimal intervals of the composite tape winding process. First, the global multi-parameter sensitivity analysis method was applied to investigate the sensitivity of each parameter in the tape winding processing. Then, the local single-parameter sensitivity analysis method was employed to calculate the sensitivity of a single parameter within the corresponding range. Finally, the stability and instability ranges of each parameter were distinguished. Meanwhile, the authors optimized the process parameter ranges and provided comprehensive optimized intervals of the winding parameters. The verification test validated that the optimized intervals of the process parameters were reliable and stable for winding products manufacturing. PMID:29385048

The impact of change in albumin assay on reference intervals, prevalence of 'hypoalbuminaemia' and albumin prescriptions.

PubMed

Coley-Grant, Deon; Herbert, Mike; Cornes, Michael P; Barlow, Ian M; Ford, Clare; Gama, Rousseau

2016-01-01

We studied the impact on reference intervals, classification of patients with hypoalbuminaemia and albumin infusion prescriptions on changing from a bromocresol green (BCG) to a bromocresol purple (BCP) serum albumin assay. Passing-Bablok regression analysis and Bland-Altman plot were used to compare Abbott BCP and Roche BCG methods. Linear regression analysis was used to compare in-house and an external laboratory Abbott BCP serum albumin results. Reference intervals for Abbott BCP serum albumin were derived in two different laboratories using pathology data from adult patients in primary care. Prescriptions for 20% albumin infusions were compared one year before and one year after changing the albumin method. Abbott BCP assay had a negative bias of approximately 6 g/L compared with Roche BCG method.There was good agreement (y = 1.04 x - 1.03; R(2 )= 0.9933) between in-house and external laboratory Abbott BCP results. Reference intervals for the serum albumin Abbott BCP assay were 31-45 g/L, different to those recommended by Pathology Harmony and the manufacturers (35-50 g/L). Following the change in method there was a large increase in the number of patients classified as hypoalbuminaemic using Pathology Harmony references intervals (32%) but not when retrospectively compared to locally derived reference intervals (16%) compared with the previous year (12%). The method change was associated with a 44.6% increase in albumin prescriptions. This equated to an annual increase in expenditure of £35,234. We suggest that serum albumin reference intervals be method specific to prevent misclassification of albumin status in patients. Change in albumin methodology may have significant impact on hospital resources. © The Author(s) 2015.

Establishment of reference intervals for plasma protein electrophoresis in Indo-Pacific green sea turtles, Chelonia mydas

PubMed Central

Flint, Mark; Matthews, Beren J.; Limpus, Colin J.; Mills, Paul C.

2015-01-01

Biochemical and haematological parameters are increasingly used to diagnose disease in green sea turtles. Specific clinical pathology tools, such as plasma protein electrophoresis analysis, are now being used more frequently to improve our ability to diagnose disease in the live animal. Plasma protein reference intervals were calculated from 55 clinically healthy green sea turtles using pulsed field electrophoresis to determine pre-albumin, albumin, α-, β- and γ-globulin concentrations. The estimated reference intervals were then compared with data profiles from clinically unhealthy turtles admitted to a local wildlife hospital to assess the validity of the derived intervals and identify the clinically useful plasma protein fractions. Eighty-six per cent {19 of 22 [95% confidence interval (CI) 65–97]} of clinically unhealthy turtles had values outside the derived reference intervals, including the following: total protein [six of 22 turtles or 27% (95% CI 11–50%)], pre-albumin [two of five, 40% (95% CI 5–85%)], albumin [13 of 22, 59% (95% CI 36–79%)], total albumin [13 of 22, 59% (95% CI 36–79%)], α- [10 of 22, 45% (95% CI 24–68%)], β- [two of 10, 20% (95% CI 3–56%)], γ- [one of 10, 10% (95% CI 0.3–45%)] and β–γ-globulin [one of 12, 8% (95% CI 0.2–38%)] and total globulin [five of 22, 23% (8–45%)]. Plasma protein electrophoresis shows promise as an accurate adjunct tool to identify a disease state in marine turtles. This study presents the first reference interval for plasma protein electrophoresis in the Indo-Pacific green sea turtle. PMID:27293722