What's what in auditory cortices?

PubMed

Retsa, Chrysa; Matusz, Pawel J; Schnupp, Jan W H; Murray, Micah M

2018-08-01

Distinct anatomical and functional pathways are postulated for analysing a sound's object-related ('what') and space-related ('where') information. It remains unresolved to which extent distinct or overlapping neural resources subserve specific object-related dimensions (i.e. who is speaking and what is being said can both be derived from the same acoustic input). To address this issue, we recorded high-density auditory evoked potentials (AEPs) while participants selectively attended and discriminated sounds according to their pitch, speaker identity, uttered syllable ('what' dimensions) or their location ('where'). Sound acoustics were held constant across blocks; the only manipulation involved the sound dimension that participants had to attend to. The task-relevant dimension was varied across blocks. AEPs from healthy participants were analysed within an electrical neuroimaging framework to differentiate modulations in response strength from modulations in response topography; the latter of which forcibly follow from changes in the configuration of underlying sources. There were no behavioural differences in discrimination of sounds across the 4 feature dimensions. As early as 90ms post-stimulus onset, AEP topographies differed across 'what' conditions, supporting a functional sub-segregation within the auditory 'what' pathway. This study characterises the spatio-temporal dynamics of segregated, yet parallel, processing of multiple sound object-related feature dimensions when selective attention is directed to them. Copyright © 2018 Elsevier Inc. All rights reserved.

Alignment method for solar collector arrays

DOEpatents

Driver, Jr., Richard B

2012-10-23

The present invention is directed to an improved method for establishing camera fixture location for aligning mirrors on a solar collector array (SCA) comprising multiple mirror modules. The method aligns the mirrors on a module by comparing the location of the receiver image in photographs with the predicted theoretical receiver image location. To accurately align an entire SCA, a common reference is used for all of the individual module images within the SCA. The improved method can use relative pixel location information in digital photographs along with alignment fixture inclinometer data to calculate relative locations of the fixture between modules. The absolute locations are determined by minimizing alignment asymmetry for the SCA. The method inherently aligns all of the mirrors in an SCA to the receiver, even with receiver position and module-to-module alignment errors.

Physico-chemical characterisation, cytotoxic activity, and biocompatibility studies of tamoxifen-loaded solid lipid nanoparticles prepared via a temperature-modulated solidification method.

PubMed

Lakkadwala, Sushant; Nguyen, Sanko; Lawrence, Joseph; Nauli, Surya M; Nesamony, Jerry

2014-01-01

Solid lipid nanoparticles (SLNs) can efficiently and efficaciously incorporate anti-cancer agents. To prepare and characterise tamoxifen (TAM)-loaded SLNs. Glyceryl monostearate, Tween-80, and trehalose were used in SLNs. SLNs were tested via dynamic light scattering (DLS), transmission electron microscopy (TEM), differential scanning calorimetry (DSC), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR). Characterisation studies revealed SLNs of about 540 nm with a negative surface charge and confirmed the entrapment of TAM in the SLNs. The entrapment efficiency was estimated to be 60%. The in vitro drug release profile demonstrated a gradual increase followed by a release plateau for several days. A drug concentration-dependent increase in cytotoxic activity was observed when the SLNs were evaluated in cell cultures. Biocompatible and stable lyophilised SLNs were successfully prepared and found to possess properties that may be utilised in an anti-cancer drug delivery system.

Modular organisation and functional analysis of dissected modular beta-mannanase CsMan26 from Caldicellulosiruptor Rt8B.4.

PubMed

Sunna, Anwar

2010-03-01

CsMan26 from Caldicellulosiruptor strain Rt8.B4 is a modular beta-mannanase consisting of two N-terminal family 27 carbohydrate-binding modules (CBMs), followed by a family 35 CBM and a family 26 glycoside hydrolase catalytic module (mannanase). A functional dissection of the full-length CsMan26 and a comprehensive characterisation of the truncated derivatives were undertaken to evaluate the role of the CBMs. Limited proteolysis was used to define biochemically the boundaries of the different structural modules in CsMan26. The full-length CsMan26 and three truncated derivatives were produced in Escherichia coli, purified and characterised. The systematic removal of the CBMs resulted in a decrease in the optimal temperature for activity and in the overall thermostability of the derivatives. Kinetic experiments indicated that the presence of the mannan-specific family 27 CBMs increased the affinity of the enzyme towards the soluble galactomannan substrate but this was accompanied by lower catalytic efficiency. The full-length CsMan26 and its truncated derivatives were unable to hydrolyse mannooligosaccharides with degree of polymerisation (DP) of three or less. The major difference in the hydrolysis pattern of larger mannooligosaccharides (DP >3) by the derivatives was determined by their abilities to further hydrolyse the intermediate sugar mannotetraose.

Precise measurement of the performance of thermoelectric modules

NASA Astrophysics Data System (ADS)

Díaz-Chao, Pablo; Muñiz-Piniella, Andrés; Selezneva, Ekaterina; Cuenat, Alexandre

2016-08-01

The potential exploitation of thermoelectric modules into mass market applications such as exhaust gas heat recovery in combustion engines requires an accurate knowledge of their performance. Further expansion of the market will also require confidence on the results provided by suppliers to end-users. However, large variation in performance and maximum operating point is observed for identical modules when tested by different laboratories. Here, we present the first metrological study of the impact of mounting and testing procedures on the precision of thermoelectric modules measurement. Variability in the electrical output due to mechanical pressure or type of thermal interface materials is quantified for the first time. The respective contribution of the temperature difference and the mean temperature to the variation in the output performance is quantified. The contribution of these factors to the total uncertainties in module characterisation is detailed.

Exomars Mission Verification Approach

NASA Astrophysics Data System (ADS)

Cassi, Carlo; Gilardi, Franco; Bethge, Boris

According to the long-term cooperation plan established by ESA and NASA in June 2009, the ExoMars project now consists of two missions: A first mission will be launched in 2016 under ESA lead, with the objectives to demonstrate the European capability to safely land a surface package on Mars, to perform Mars Atmosphere investigation, and to provide communi-cation capability for present and future ESA/NASA missions. For this mission ESA provides a spacecraft-composite, made up of an "Entry Descent & Landing Demonstrator Module (EDM)" and a Mars Orbiter Module (OM), NASA provides the Launch Vehicle and the scientific in-struments located on the Orbiter for Mars atmosphere characterisation. A second mission with it launch foreseen in 2018 is lead by NASA, who provides spacecraft and launcher, the EDL system, and a rover. ESA contributes the ExoMars Rover Module (RM) to provide surface mobility. It includes a drill system allowing drilling down to 2 meter, collecting samples and to investigate them for signs of past and present life with exobiological experiments, and to investigate the Mars water/geochemical environment, In this scenario Thales Alenia Space Italia as ESA Prime industrial contractor is in charge of the design, manufacturing, integration and verification of the ESA ExoMars modules, i.e.: the Spacecraft Composite (OM + EDM) for the 2016 mission, the RM for the 2018 mission and the Rover Operations Control Centre, which will be located at Altec-Turin (Italy). The verification process of the above products is quite complex and will include some pecu-liarities with limited or no heritage in Europe. Furthermore the verification approach has to be optimised to allow full verification despite significant schedule and budget constraints. The paper presents the verification philosophy tailored for the ExoMars mission in line with the above considerations, starting from the model philosophy, showing the verification activities flow and the sharing of tests between the different levels (system, modules, subsystems, etc) and giving an overview of the main test defined at Spacecraft level. The paper is mainly focused on the verification aspects of the EDL Demonstrator Module and the Rover Module, for which an intense testing activity without previous heritage in Europe is foreseen. In particular the Descent Module has to survive to the Mars atmospheric entry and landing, its surface platform has to stay operational for 8 sols on Martian surface, transmitting scientific data to the Orbiter. The Rover Module has to perform 180 sols mission in Mars surface environment. These operative conditions cannot be verified only by analysis; consequently a test campaign is defined including mechanical tests to simulate the entry loads, thermal test in Mars environment and the simulation of Rover operations on a 'Mars like' terrain. Finally, the paper present an overview of the documentation flow defined to ensure the correct translation of the mission requirements in verification activities (test, analysis, review of design) until the final verification close-out of the above requirements with the final verification reports.

Model Development of Degradation of PV Modules Backsheet with Locating Place of Module

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kempe, Michael D; Wang, Yu; Fairbrother, Andrew

Performance of a photovoltaic (PV) module is related to the micro-environment around the module. The position of photovoltaic modules in an array row have a large effect on the yellowing and gloss of PV module backsheet exposed in Dfa climatic zone (Gaithersburg, MD) with a polyethylene naphthalate (PEN) outer layer. Stress/Response models of yellowing and gloss-losing as function of location parameters of module, including the shed, row, measurement position in a same module and the distance of module location to the row center, are under development. The module installation height had the greatest influence on degradation of PEN PV backsheetmore » in the Dfa climatic zone. The module backsheets at the end of an array have higher degradation rate (edge effect). The edge effect decreases with increasing of module installation heights.« less

Differences in Visual-Spatial Input May Underlie Different Compression Properties of Firing Fields for Grid Cell Modules in Medial Entorhinal Cortex

PubMed Central

Raudies, Florian; Hasselmo, Michael E.

2015-01-01

Firing fields of grid cells in medial entorhinal cortex show compression or expansion after manipulations of the location of environmental barriers. This compression or expansion could be selective for individual grid cell modules with particular properties of spatial scaling. We present a model for differences in the response of modules to barrier location that arise from different mechanisms for the influence of visual features on the computation of location that drives grid cell firing patterns. These differences could arise from differences in the position of visual features within the visual field. When location was computed from the movement of visual features on the ground plane (optic flow) in the ventral visual field, this resulted in grid cell spatial firing that was not sensitive to barrier location in modules modeled with small spacing between grid cell firing fields. In contrast, when location was computed from static visual features on walls of barriers, i.e. in the more dorsal visual field, this resulted in grid cell spatial firing that compressed or expanded based on the barrier locations in modules modeled with large spacing between grid cell firing fields. This indicates that different grid cell modules might have differential properties for computing location based on visual cues, or the spatial radius of sensitivity to visual cues might differ between modules. PMID:26584432

New investigations around CYP11A1 and its possible involvement in an androstenone QTL characterised in Large White pigs

PubMed Central

2011-01-01

Background Previously, in boars with extreme androstenone levels, differential expression of the CYP11A1 gene in the testes has been characterised. CYP11A1 is located in a region where a QTL influencing boar fat androstenone levels has been detected in a Large White pig population. Clarifying the role of CYP11A1 in boar taint is important because it catalyses the initial step of androstenone synthesis and also of steroid synthesis. Results A genome-wide association study located CYP11A1 at approximately 1300 kb upstream from SNP H3GA0021967, defining the centre of the region containing the QTL for androstenone variation. In this study, we partially sequenced the CYP11A1 gene and identified several new single nucleotide polymorphisms (SNP) within it. Characterisation of one animal, heterozygous for CYP11A1 testicular expression but homozygous for a haplotype of a large region containing CYP11A1, revealed that variation of CYP11A1 expression is probably regulated by a mutation located downstream from the SNP H3GA0021967. We analysed CYP11A1 expression in LW families according to haplotypes of the QTL region's centre. Effects of haplotypes on CYP11A1 expression and on androstenone accumulation were not concordant. Conclusion This study shows that testicular expression of CYP11A1 is not solely responsible for the QTL influencing boar fat androstenone levels. As a conclusion, we propose to refute the hypothesis that a single mutation located near the centre of the QTL region could control androstenone accumulation in fat by regulating the CYP11A1 expression. PMID:21504607

Preventing or Inventing? Understanding the Effects of Non-Prescriptive Design Briefs

ERIC Educational Resources Information Center

Oliveira, Sonja; Marco, Elena

2017-01-01

This paper discusses observations of an architecture and environmental engineering undergraduate design studio project assigned to 4th year students at a UK university. In the UK, most architecture courses are characterised by a high proportion of design studio teaching supported by varying amount of technical modules that include environmental…

Saturn Apollo Program

NASA Image and Video Library

1970-04-01

Apollo 13 onboard photo: This view of the severely damaged Apollo 13 Service Module was photographed from the Lunar Module/Command Module following the jettison of the Service Module. As seen here, an entire panel of the Service Module was blown away by the apparent explosion of oxygen tank number two located in Sector 4 of the Service Module. Two of the three fuel cells are visible just forward (above) the heavily damaged area. Three fuel cells, two oxygen tanks, and two hydrogen tanks, are located in Sector 4. The damaged area is located above the S-band high gain anterna. Nearest the camera is the Service Propulsion System (SPS) engine and nozzle. The damage to the Service Module caused the Apollo 13 crewmen to use the Lunar Module as a lifeboat. The Lunar Module was jettisoned by the Command Module just prior to Earth re-entry.

Systems and methods for pressure and temperature measurement

DOEpatents

Challener, William Albert; Airey, Li

2016-12-06

A measurement system in one embodiment includes an acquisition module and a determination module. The acquisition module is configured to acquire resonant frequency information corresponding to a sensor disposed in a remote location from the acquisition module. The resonant frequency information includes first resonant frequency information for a first resonant frequency of the sensor corresponding to environmental conditions of the remote location, and also includes second resonant frequency information for a different, second resonant frequency of the sensor corresponding to the environmental conditions of the remote location. The determination module is configured to use the first resonant frequency information and the second resonant frequency information to determine the temperature and the pressure at the remote location.

Key interactions by conserved polar amino acids located at the transmembrane helical boundaries in Class B GPCRs modulate activation, effector specificity and biased signalling in the glucagon-like peptide-1 receptor.

PubMed

Wootten, Denise; Reynolds, Christopher A; Smith, Kevin J; Mobarec, Juan C; Furness, Sebastian G B; Miller, Laurence J; Christopoulos, Arthur; Sexton, Patrick M

2016-10-15

Class B GPCRs can activate multiple signalling effectors with the potential to exhibit biased agonism in response to ligand stimulation. Previously, we highlighted key TM domain polar amino acids that were crucial for the function of the GLP-1 receptor, a key therapeutic target for diabetes and obesity. Using a combination of mutagenesis, pharmacological characterisation, mathematical and computational molecular modelling, this study identifies additional highly conserved polar residues located towards the TM helical boundaries of Class B GPCRs that are important for GLP-1 receptor stability and/or controlling signalling specificity and biased agonism. This includes (i) three positively charged residues (R3.30 227 , K4.64 288 , R5.40 310 ) located at the extracellular boundaries of TMs 3, 4 and 5 that are predicted in molecular models to stabilise extracellular loop 2, a crucial domain for ligand affinity and receptor activation; (ii) a predicted hydrogen bond network between residues located in TMs 2 (R2.46 176 ), 6 (R6.37 348 ) and 7 (N7.61 406 and E7.63 408 ) at the cytoplasmic face of the receptor that is important for stabilising the inactive receptor and directing signalling specificity, (iii) residues at the bottom of TM 5 (R5.56 326 ) and TM6 (K6.35 346 and K6.40 351 ) that are crucial for receptor activation and downstream signalling; (iv) residues predicted to be involved in stabilisation of TM4 (N2.52 182 and Y3.52 250 ) that also influence cell signalling. Collectively, this work expands our understanding of peptide-mediated signalling by the GLP-1 receptor. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

Station Module Move in 4K Video Resolution

NASA Image and Video Library

2015-06-09

Robotics flight controllers in Mission Control Houston and Canada detached the large Permanent Multipurpose Module (PMM), used as a supply depot on the orbital laboratory, from the Earth-facing port of the Unity module and robotically relocated it to the forward port of the Tranquility module. This move cleared the Unity port for its conversion into the spare berthing location for U.S. cargo spacecraft; the Earth-facing port on Harmony is the primary docking location. Harmony’s space-facing port currently is the spare berthing location for cargo vehicles, so this move frees that location to be used in conjunction with Harmony’s forward port as the arrival locations for commercial crew spacecraft.

Characterisation of novel thin n-in-p planar pixel modules for the ATLAS Inner Tracker upgrade

NASA Astrophysics Data System (ADS)

Beyer, J.-C.; La Rosa, A.; Macchiolo, A.; Nisius, R.; Savic, N.; Taibah, R.

2018-01-01

In view of the high luminosity phase of the LHC (HL-LHC) to start operation around 2026, a major upgrade of the tracker system for the ATLAS experiment is in preparation. The expected neutron equivalent fluence of up to 2.4×1016 1 MeV neq./cm2 at the innermost layer of the pixel detector poses the most severe challenge. Thanks to their low material budget and high charge collection efficiency after irradiation, modules made of thin planar pixel sensors are promising candidates to instrument these layers. To optimise the sensor layout for the decreased pixel cell size of 50×50 μm2, TCAD device simulations are being performed to investigate the charge collection efficiency before and after irradiation. In addition, sensors of 100-150 μm thickness, interconnected to FE-I4 read-out chips featuring the previous generation pixel cell size of 50×250 μm2, are characterised with testbeams at the CERN-SPS and DESY facilities. The performance of sensors with various designs, irradiated up to a fluence of 1×1016 neq./cm2, is compared in terms of charge collection and hit efficiency. A replacement of the two innermost pixel layers is foreseen during the lifetime of HL-LHC . The replacement will require several months of intervention, during which the remaining detector modules cannot be cooled. They are kept at room temperature, thus inducing an annealing. The performance of irradiated modules will be investigated with testbeam campaigns and the method of accelerated annealing at higher temperatures.

Effects of rainfall events on the evapotranspiration retrieved by an energy balance model

NASA Astrophysics Data System (ADS)

Maltese, Antonino; Cammalleri, Carmelo; Ciraolo, Giuseppe; La Loggia, Goffredo

2009-09-01

An alternative way to map the actual evapotranspiration (ET) spatial distribution at daily scale is the application of residual surface energy balance models to satellite images that are characterised by high temporal frequency and moderate spatial resolution, like those acquired by the MODIS sensors on board of TERRA and AQUA platforms. Within this research the well-known SEBAL model has been applied on an area located in the southern part of Sicily (Imera Meridionale catchment) using four images acquired between the 27th of March and the 11th of April 2007. The catchment extends for about 2000 km2 and includes both mountains and hill areas: the first are located in the northern part (the Madonie Mountains), while the latter characterise the southern area. The altitude ranges between 0 and 1900 m a.s.l., with an average altitude of 500 m a.s.l.. In order to validate the outputs of the energy balance model, a flux tower has been installed within a homogeneous field of cereal located in the valley part of the basin (close to Licata town within the Quignones Farm), characterised by semi-arid conditions. The selected images have been acquired before and after a three-rainfall events period (5 mm during the night between the 2nd and the 3rd of April, 17 mm on the 3rd evening, 8 mm on the 4th thoroughly all the day). The study area is mostly cultivated with cereals that, during the study period, were characterised by flag and bolting phenological phases. In the first, the leaf at the stem apex assumes a flag shape, while during the latter, the terminal part of the stem a barrel shape enlargement containing the ear appears. The study aim is the evaluation of the energy partition between sensible and latent heat fluxes, due to the increased water availability in a period characterised by a significant vegetation growth. The comparison between model results and flux tower measurements shows that both the latent heat flux and the other energy balance components are modelled with high accuracy. Moreover, the model well represents the variation in time of energy partition, which increases from 0.5 up to 0.65 in terms of evaporative fraction (Λ). Therefore a greater percent of energy is used to evapotranspiration after the rainfall events.

Wall paintings studied using Raman spectroscopy: a comparative study between various assays of cross sections and external layers.

PubMed

Perez-Rodriguez, Jose Luis; Robador, Maria Dolores; Centeno, Miguel Angel; Siguenza, Belinda; Duran, Adrian

2014-01-01

This work describes a comparative study between in situ applications of portable Raman spectroscopy and direct laboratory measurements using micro-Raman spectroscopy on the surface of small samples and of cross sections. The study was performed using wall paintings from different sites of the Alcazar of Seville. Little information was obtained using a portable Raman spectrometer due to the presence of an acrylic polymer, calcium oxalate, calcite and gypsum that was formed or deposited on the surface. The pigments responsible for different colours, except cinnabar, were not detected by the micro-Raman spectroscopy study of the surface of small samples taken from the wall paintings due to the presence of surface contaminants. The pigments and plaster were characterised using cross sections. The black colour consisted of carbon black. The red layers were formed by cinnabar and white lead or by iron oxides. The green and white colours were composed of green emerald or atacamite and calcite, respectively. Pb3O4 has also been characterised. The white layers (plaster) located under the colour layers consisted of calcite, quartz and feldspars. The fresco technique was used to create the wall paintings. A wall painting located on a gypsum layer was also studied. The Naples yellow in this wall painting was not characterised due to the presence of glue and oils. This study showed the advantage of studying cross sections to completely characterise the pigments and plaster in the studied wall paintings. Copyright © 2013 Elsevier B.V. All rights reserved.

Questioning the Character and Significance of Convergence between Social Network and Professional Practices in Teacher Education

ERIC Educational Resources Information Center

Turvey, Keith

2012-01-01

This paper captures and characterises the interplay between a group of student teachers' narratives of social network practice and their emergent professional practice with technologies. Teachers on an Initial Teacher Education programme in the UK spent a semester studying a module that synthesised university-based lectures with a professional…

Evidence of Fearlessness in Behaviourally Disordered Children: A Study on Startle Reflex Modulation

ERIC Educational Resources Information Center

van Goozen, Stephanie H. M.; Snoek, Heddeke; Matthys, Walter; van Rossum, Inge; van Engeland, Herman

2004-01-01

Background: Patterns of low heart rate, skin conductance and cortisol seem to characterise children with disruptive behaviour disorder (DBD). Until now, the startle paradigm has not been used in DBD children. We investigated whether DBD children, like adult psychopaths, process emotional stimuli in an abnormal way. Method: Twenty-one DBD and 33…

Not the Norm: The Potential of Tree Analysis of Performance Data from Students in a Foundation Mathematics Module

ERIC Educational Resources Information Center

Kirby, Nicola; Dempster, Edith

2015-01-01

Quantitative methods of data analysis usually involve inferential statistics, and are not well known for their ability to reflect the intricacies of a diverse student population. The South African tertiary education sector is characterised by extreme inequality and diversity. Foundation programmes address issues of inequality of access by…

Nonlinear Stage of Modulation Instability for a Fifth-Order Nonlinear Schrödinger Equation

NASA Astrophysics Data System (ADS)

Jia, Hui-Xian; Shan, Dong-Ming

2017-10-01

In this article, a fifth-order nonlinear Schrödinger equation, which can be used to characterise the solitons in the optical fibre and inhomogeneous Heisenberg ferromagnetic spin system, has been investigated. Akhmediev breather, Kuzentsov soliton, and generalised soliton have all been attained via the Darbox transformation. Propagation and interaction for three-type breathers have been studied: the types of breather are determined by the module and complex angle of parameter ξ; interaction between Akhmediev breather and generalised soliton displays a phase shift, whereas the others do not. Modulation instability of the generalised solitons have been analysed: a small perturbation can develop into a rogue wave, which is consistent with the results of rogue wave solutions.

Damage detection and locating using tone burst and continuous excitation modulation method

NASA Astrophysics Data System (ADS)

Li, Zheng; Wang, Zhi; Xiao, Li; Qu, Wenzhong

2014-03-01

Among structural health monitoring techniques, nonlinear ultrasonic spectroscopy methods are found to be effective diagnostic approach to detecting nonlinear damage such as fatigue crack, due to their sensitivity to incipient structural changes. In this paper, a nonlinear ultrasonic modulation method was developed to detect and locate a fatigue crack on an aluminum plate. The method is different with nonlinear wave modulation method which recognizes the modulation of low-frequency vibration and high-frequency ultrasonic wave; it recognizes the modulation of tone burst and high-frequency ultrasonic wave. In the experiment, a Hanning window modulated sinusoidal tone burst and a continuous sinusoidal excitation were simultaneously imposed on the PZT array which was bonded on the surface of an aluminum plate. The modulations of tone burst and continuous sinusoidal excitation was observed in different actuator-sensor paths, indicating the presence and location of fatigue crack. The results of experiments show that the proposed method is capable of detecting and locating the fatigue crack successfully.

Neurotensin enhances glutamatergic EPSCs in VTA neurons by acting on different neurotensin receptors.

PubMed

Bose, Poulomee; Rompré, Pierre-Paul; Warren, Richard A

2015-11-01

Neurotensin (NT) is an endogenous neuropeptide that modulates dopamine and glutamate neurotransmission in several limbic regions innervated by neurons located in the ventral tegmental area (VTA). While several studies showed that NT exerted a direct modulation on VTA dopamine neurons less is known about its role in the modulation of glutamatergic neurotransmission in this region. The present study was aimed at characterising the effects of NT on glutamate-mediated responses in different populations of VTA neurons. Using whole cell patch clamp recording technique in horizontal rat brain slices, we measured the amplitude of glutamatergic excitatory post-synaptic currents (EPSCs) evoked by electrical stimulation of VTA afferents before and after application of different concentrations of NT1-13 or its C-terminal fragment, NT8-13. Neurons were classified as either Ih(+) or Ih(-) based on the presence or absence of a hyperpolarisation activated cationic current (Ih). We found that NT1-13 and NT8-13 produced comparable concentration dependent increase in the amplitude of EPSCs in both Ih(+) and Ih(-) neurons. In Ih(+) neurons, the enhancement effect of NT8-13 was blocked by both antagonists, while in Ih(-) neurons it was blocked by the NTS1/NTS2 antagonist, SR142948A, but not the preferred NTS1 antagonist, SR48692. In as much as Ih(-) neurons are non-dopaminergic neurons and Ih(+) neurons represent both dopamine and non-dopamine neurons, we can conclude that NT enhances glutamatergic mediated responses in dopamine, and in a subset of non-dopamine, neurons by acting respectively on NTS1 and an NT receptor other than NTS1. Copyright © 2015 Elsevier Inc. All rights reserved.

Characterising the structure of quasi-periodic mixing events in stratified turbulent Taylor-Couette flow

NASA Astrophysics Data System (ADS)

Singh, Kanwar Nain; Partridge, Jamie; Dalziel, Stuart; Caulfield, C. P.; Mathematical Underpinnings of Stratified Turbulence (MUST) Team

2017-11-01

We present results from experiments conducted to study mixing in a two-layer stably-stratified turbulent Taylor-Couette flow. It has previously been observed that there is a quasi-periodic mixing event located at the interface separating the layers. We observe, through conductivity probe measurements, that the power of the mixing event in the frequency spectrum of the density data at the interface is higher when measured near the inner cylinder than in the middle of the annular gap. This is consistent with Oglethorpe's (2014) hypothesis that the mixing structure is triggered near the inner cylinder, and then advects and decays or disperses radially. We also observe that at Ri =g/'Ro (RiΩi)2 7 , where Ri, Ro are the inner and outer cylinder radius, respectively, g ' the reduced gravity characterising the density jump between the layers and Ωi is the rotation rate of the inner cylinder, the power drops significantly at all radial locations, which is reminiscent of the onset of the enhanced flux regime as observed by Oglethorpe et al. (2013). We perform experiments to characterise the spatial extent and dynamics of this mixing structure using particle image velocimetry (PIV) giving further insights into this important mixing process. EPSRC programme Grant EP/K034529/1 & SGPC-CCT Scholarship.

Field experience and performance evaluation of a medium-concentration CPV system

NASA Astrophysics Data System (ADS)

Norton, Matthew; Bentley, Roger; Georghiou, George E.; Chonavel, Sylvain; De Mutiis, Alfredo

2012-10-01

With the aim of gaining experience and performance data from location with a harsh summer climate, a 70 X concentrating photovoltaic (CPV) system was installed in Janurary 2009 in Nicosia, Cyprus. The performance of this system has been monitored using regular current-voltage characterisations for three years. Over this period, the output of the system has remained fairly constant. Measured performance ratios varied from 0.79 to 0.86 in the winter, but fell to 0.64 over the year when left uncleaned. Operating cell temperatures were modeled and found to be similar to those of flat plate modules. The most significant causes of energy loss have been identified as originating from tracking issues and soiling. Losses due to soiling could account for a drop in output of 0.2% per day. When cleaned and properly oriented, the normalized output of the system has remained constant, suggesting that this particular design is tolerant to the physical strain of long-term outdoor exposure in harsh summer conditions. Regular cleaning and reliable tracker operation are shown to be essential for maximizing energy yield.

Inflamed juvenile conjunctival naevus: clinicopathological characterisation

PubMed Central

Zamir, Ehud; Mechoulam, Hadas; Micera, Alessandra; Levi-Schaffer, Francesca; Pe'er, Jacob

2002-01-01

Aim: Inflamed juvenile conjunctival naevi (IJCN) are often erroneously suspected to be malignant because of rapid growth. Their clinical and histopathological features have not been characterised in series of patients. The aim of the study is to characterise IJCN clinically and histopathologically. Methods: This is a retrospective non-randomised clinicopathological study. All patients younger than 20 years with conjunctival naevi which were excised between 1990 and 2000 were included. The clinical signs of the affected patients and the histopathological findings of the excised lesions were characterised. Results: A total of 63 conjunctival naevi were resected. 25% of the patients had simple compound conjunctival naevi and 75% had compound naevi with prominent inflammatory histological features (discrete lymphocyte aggregates, plasma cells, and eosinophils). Epithelial cysts and solid epithelial islands were common in the IJCN. The IJCN were all located at or near the limbus, and characterised by recurrent periods of congestion and growth. 75% of the IJCN patients with complete medical records had a history of allergic disease. Marked conjunctival papillary reaction was present in all of the patients, indicating a possible conjunctival allergy. Conclusions: IJCN is a unique entity, different from simple compound conjunctival naevus. Its association with allergic conjunctivitis is suggestive, and despite periods of alarmingly rapid growth, is histologically benign. PMID:11801498

Gamma-ray imaging system for real-time measurements in nuclear waste characterisation

NASA Astrophysics Data System (ADS)

Caballero, L.; Albiol Colomer, F.; Corbi Bellot, A.; Domingo-Pardo, C.; Leganés Nieto, J. L.; Agramunt Ros, J.; Contreras, P.; Monserrate, M.; Olleros Rodríguez, P.; Pérez Magán, D. L.

2018-03-01

A compact, portable and large field-of-view gamma camera that is able to identify, locate and quantify gamma-ray emitting radioisotopes in real-time has been developed. The device delivers spectroscopic and imaging capabilities that enable its use it in a variety of nuclear waste characterisation scenarios, such as radioactivity monitoring in nuclear power plants and more specifically for the decommissioning of nuclear facilities. The technical development of this apparatus and some examples of its application in field measurements are reported in this article. The performance of the presented gamma-camera is also benchmarked against other conventional techniques.

Swedish Plectida (Nematoda). Part 9. The genus Leptolaimoides Vitiello, 1971.

PubMed

Holovachov, Oleksandr

2015-05-01

Three known and two new species of Leptolaimoides are described from bottom sediments collected in Skagerrak off the west coast of Sweden. The following known species are redescribed: Leptolaimoides haploopis Jensen, 1978, L. tubulosus Vitiello, 1971 and L. hexatubulosus Hoang Lai-Phu et al., 2009. Leptolaimoides filicaudatus sp. n. is characterised by the 431-543 µm long body; cephalic sensilla papilliform; amphid 23-26 µm long, located 9-10 µm from anterior end; first body pore located 35-37 µm from anterior end; lateral field simple along most of body, areolated on tail, arising 36-40 µm from anterior end; female without supplements, vagina without pars refringens, vulva midventral; male without tubular and without alveolar supplements; spicules arcuate and 16 µm long. Leptolaimoides leptomicron sp. n. is characterised by the 776-847 µm long body; cephalic sensilla papilliform; amphid 15-17 µm long, located 9-13 µm from anterior end; first body pore located 40-46 µm from anterior end; lateral field areolated, arising 26-28 µm from anterior end; female without supplements, vagina without pars refringens, vulva midventral; male with three tubular and without alveolar supplements, spicules arcuate and 28-29 µm long. The diagnosis of the genus Leptolaimoides is emended and a tabular compendium and dichotomous identification key to species of the genus Leptolaimoides are provided.

View of damaged Apollo 13 Service Module from the Lunar/Command Modules

NASA Image and Video Library

1970-04-17

This view of the damaged Apollo 13 Service Module (SM) was photographed from the Lunar Module/Command Module following SM jettisoning. As seen here, an entire panel on the SM was blown away by the apparent explosion of oxygen tank number two located in Sector 4 of the SM. Two of the three fuel cells are visible just forward (above) the heavily damaged area. Three fuel cells, two oxygen tanks, and two hydrogen tanks are locate in Sector 4. The damaged area is located above the S-band high gain antenna. Nearest the camera is the Service Propulsion System (SPS) engine and nozzle. The damage to the SM caused the Apollo 13 crewmen to use the Lunar Module (LM) as a "lifeboat". The LM was jettisoned just prior to Earth reentry by the Command Module.

KENNEDY SPACE CENTER, FLA. - The U.S. Node 2 is undergoing a Multi-Element Integrated Test (MEIT) in the Space Station Processing Facility. Node 2 attaches to the end of the U.S. Lab on the ISS and provides attach locations for the Japanese laboratory, European laboratory, the Centrifuge Accommodation Module and, eventually, Multipurpose Logistics Modules. It will provide the primary docking location for the Shuttle when a pressurized mating adapter is attached to Node 2. Installation of the module will complete the U.S. Core of the ISS.

NASA Image and Video Library

2003-08-27

KENNEDY SPACE CENTER, FLA. - The U.S. Node 2 is undergoing a Multi-Element Integrated Test (MEIT) in the Space Station Processing Facility. Node 2 attaches to the end of the U.S. Lab on the ISS and provides attach locations for the Japanese laboratory, European laboratory, the Centrifuge Accommodation Module and, eventually, Multipurpose Logistics Modules. It will provide the primary docking location for the Shuttle when a pressurized mating adapter is attached to Node 2. Installation of the module will complete the U.S. Core of the ISS.

Source-term characterisation and solid speciation of plutonium at the Semipalatinsk NTS, Kazakhstan.

PubMed

Nápoles, H Jiménez; León Vintró, L; Mitchell, P I; Omarova, A; Burkitbayev, M; Priest, N D; Artemyev, O; Lukashenko, S

2004-01-01

New data on the concentrations of key fission/activation products and transuranium nuclides in samples of soil and water from the Semipalatinsk Nuclear Test Site are presented and interpreted. Sampling was carried out at Ground Zero, Lake Balapan, the Tel'kem craters and reference locations within the test site boundary well removed from localised sources. Radionuclide ratios have been used to characterise the source term(s) at each of these sites. The geochemical partitioning of plutonium has also been examined and it is shown that the bulk of the plutonium contamination at most of the sites examined is in a highly refractory, non-labile form.

RF transmission line and drill/pipe string switching technology for down-hole telemetry

DOEpatents

Clark, David D [Santa Fe, NM; Coates, Don M [Santa Fe, NM

2007-08-14

A modulated reflectance well telemetry apparatus having an electrically conductive pipe extending from above a surface to a point below the surface inside a casing. An electrical conductor is located at a position a distance from the electrically conductive pipe and extending from above the surface to a point below the surface. Modulated reflectance apparatus is located below the surface for modulating well data into a RF carrier transmitted from the surface and reflecting the modulated carrier back to the surface. A RF transceiver is located at the surface and is connected between the electrically conductive pipe and the electrical conductor for transmitting a RF signal that is confined between the electrically conductive well pipe and the electrical conductor to the modulated reflectance apparatus, and for receiving reflected data on the well from the modulated reflectance apparatus.

Characterisation and molecular association of Nigerian and Sudanese Acacia gum exudates

USDA-ARS?s Scientific Manuscript database

The chemical and physicochemical characteristics of gum exudate samples harvested from mature trees of Acacia senegal at two specific locations in Nigeria have been investigated together with gum samples harvested from Acacia senegal and Acacia seyal originating from Sudan. The monosaccharide sugar ...

Characterising food environment exposure at home, at work, and along commuting journeys using data on adults in the UK.

PubMed

Burgoine, Thomas; Monsivais, Pablo

2013-06-27

Socio-ecological models of behaviour suggest that dietary behaviours are potentially shaped by exposure to the food environment ('foodscape'). Research on associations between the foodscape and diet and health has largely focussed on foodscapes around the home, despite recognition that non-home environments are likely to be important in a more complete assessment of foodscape exposure. This paper characterises and describes foodscape exposure of different types, at home, at work, and along commuting routes for a sample of working adults in Cambridgeshire, UK. Home and work locations, and transport habits for 2,696 adults aged 29-60 were drawn from the Fenland Study, UK. Food outlet locations were obtained from local councils and classified by type - we focus on convenience stores, restaurants, supermarkets and takeaway food outlets. Density of and proximity to food outlets was characterised at home and work. Commuting routes were modelled based on the shortest street network distance between home and work, with exposure (counts of food outlets) that accounted for travel mode and frequency. We describe these three domains of food environment exposure using descriptive and inferential statistics. For all types of food outlet, we found very different foodscapes around homes and workplaces (with overall outlet exposure at work 125% higher), as well as a potentially substantial exposure contribution from commuting routes. On average, work and commuting environments each contributed to foodscape exposure at least equally to residential neighbourhoods, which only accounted for roughly 30% of total exposure. Furthermore, for participants with highest overall exposure to takeaway food outlets, workplaces accounted for most of the exposure. Levels of relative exposure between home, work and commuting environments were poorly correlated. Relying solely on residential neighbourhood characterisation greatly underestimated total foodscape exposure in this sample, with levels of home exposure unrelated to levels of away from home exposure. Such mis-estimation is likely to be expressed in analyses as attenuated parameter estimates, suggesting a minimal 'environmental' contribution to outcomes of interest. Future work should aim to assess exposure more completely through characterising environments beyond the residential neighbourhood, where behaviours related to food consumption are likely to occur.

Pesticide fate at regional scale: Development of an integrated model approach and application

NASA Astrophysics Data System (ADS)

Herbst, M.; Hardelauf, H.; Harms, R.; Vanderborght, J.; Vereecken, H.

As a result of agricultural practice many soils and aquifers are contaminated with pesticides. In order to quantify the side-effects of these anthropogenic impacts on groundwater quality at regional scale, a process-based, integrated model approach was developed. The Richards’ equation based numerical model TRACE calculates the three-dimensional saturated/unsaturated water flow. For the modeling of regional scale pesticide transport we linked TRACE with the plant module SUCROS and with 3DLEWASTE, a hybrid Lagrangian/Eulerian approach to solve the convection/dispersion equation. We used measurements, standard methods like pedotransfer-functions or parameters from literature to derive the model input for the process model. A first-step application of TRACE/3DLEWASTE to the 20 km 2 test area ‘Zwischenscholle’ for the period 1983-1993 reveals the behaviour of the pesticide isoproturon. The selected test area is characterised by an intense agricultural use and shallow groundwater, resulting in a high vulnerability of the groundwater to pesticide contamination. The model results stress the importance of the unsaturated zone for the occurrence of pesticides in groundwater. Remarkable isoproturon concentrations in groundwater are predicted for locations with thin layered and permeable soils. For four selected locations we used measured piezometric heads to validate predicted groundwater levels. In general, the model results are consistent and reasonable. Thus the developed integrated model approach is seen as a promising tool for the quantification of the agricultural practice impact on groundwater quality.

Characterisation of the gene cluster for L-rhamnose catabolism in the yeast Scheffersomyces (Pichia) stipitis

Treesearch

Outi M. Koivistoinen; Mikko Arvas; Jennifer R. Headman; Martina Andberg; Merja Penttilä; Thomas W. Jeffries; Peter Richard

2012-01-01

In Scheffersomyces (Pichia) stipitis and related fungal species the genes for L-rhamnose catabolism RHA1, LRA2, LRA3 and LRA4 but not LADH are clustered. We find that located next to the cluster is a transcription...

KENNEDY SPACE CENTER, FLA. - An overview of the Space Station Processing Facility shows workstands and ISS elements. The most recent additions are the Japanese Experiment Module (JEM)’s pressurized module and the Italian-built Node 2. The pressurized module is the first element of the JEM, Japan’s primary contribution to the Space Station, to be delivered to KSC. It will enhance the unique research capabilities of the orbiting complex by providing an additional shirt-sleeve environment for astronauts to conduct science experiments. Node 2 will be installed on the end of the U.S. Lab and provides attach locations for the Japanese laboratory, European laboratory, the Centrifuge Accommodation Module and, later, Multipurpose Logistics Modules. It will provide the primary docking location for the Shuttle when a pressurized mating adapter is attached to Node 2. Installation of the module will complete the U.S. Core of the ISS.

NASA Image and Video Library

2003-06-06

KENNEDY SPACE CENTER, FLA. - An overview of the Space Station Processing Facility shows workstands and ISS elements. The most recent additions are the Japanese Experiment Module (JEM)’s pressurized module and the Italian-built Node 2. The pressurized module is the first element of the JEM, Japan’s primary contribution to the Space Station, to be delivered to KSC. It will enhance the unique research capabilities of the orbiting complex by providing an additional shirt-sleeve environment for astronauts to conduct science experiments. Node 2 will be installed on the end of the U.S. Lab and provides attach locations for the Japanese laboratory, European laboratory, the Centrifuge Accommodation Module and, later, Multipurpose Logistics Modules. It will provide the primary docking location for the Shuttle when a pressurized mating adapter is attached to Node 2. Installation of the module will complete the U.S. Core of the ISS.

KENNEDY SPACE CENTER, FLA. - A view of the Space Station Processing Facility shows workstands and ISS elements. The most recent additions are the Japanese Experiment Module (JEM)’s pressurized module and the Italian-built Node 2. The pressurized module is the first element of the JEM, Japan’s primary contribution to the Space Station, to be delivered to KSC. It will enhance the unique research capabilities of the orbiting complex by providing an additional shirt-sleeve environment for astronauts to conduct science experiments. Node 2 will be installed on the end of the U.S. Lab and provides attach locations for the Japanese laboratory, European laboratory, the Centrifuge Accommodation Module and, later, Multipurpose Logistics Modules. It will provide the primary docking location for the Shuttle when a pressurized mating adapter is attached to Node 2. Installation of the module will complete the U.S. Core of the ISS.

NASA Image and Video Library

2003-06-06

KENNEDY SPACE CENTER, FLA. - A view of the Space Station Processing Facility shows workstands and ISS elements. The most recent additions are the Japanese Experiment Module (JEM)’s pressurized module and the Italian-built Node 2. The pressurized module is the first element of the JEM, Japan’s primary contribution to the Space Station, to be delivered to KSC. It will enhance the unique research capabilities of the orbiting complex by providing an additional shirt-sleeve environment for astronauts to conduct science experiments. Node 2 will be installed on the end of the U.S. Lab and provides attach locations for the Japanese laboratory, European laboratory, the Centrifuge Accommodation Module and, later, Multipurpose Logistics Modules. It will provide the primary docking location for the Shuttle when a pressurized mating adapter is attached to Node 2. Installation of the module will complete the U.S. Core of the ISS.

Characterising soil surface roughness with a frequency modulated polarimetric radar

NASA Astrophysics Data System (ADS)

Seeger, Manuel; Gronz, Oliver; Beiske, Joshua; Klein, Tobias

2014-05-01

Soil surface roughness is considered crucial for soil erosion as it determines the effective surface exposed to the raindrop impact. It regulates surface runoff velocity and it causes runoff concentration. But a comprehensive characterisation of the shape of the soils' surface is still difficult to achieve. Photographic systems and terrestrial laser-scanning are nowadays able to generate high resolution DEMs, but the derivation of roughness parameters is still not clear. Spaceborne radar systems are used for about 3 decades for earth survey. Spatial soil moisture distribution, ice sheet monitoring and earth-wide topographic survey are the main objectives of these radar systems, working generally with frequencies <10 GHz. Contrasting with this, technologies emitting frequencies up to 77 GHz are generally used for object tracking purposes. But it is known, that the reflection characteristics, such as intensity and polarisation, strongly depend on the properties of the target object. A new design of a frequency modulated continuous wave radar, emitting a right hand shaped circular polarization and receiving both polarization directions, right and left-hand shaped, is tested here for its ability to detect and quantify different surface roughness. The reflection characteristics of 4 different materials 1) steel, 2) sand (0,5-1 mm), 3) fine (2-4 mm) and 4) coarse (15-30 mm) rock-fragments and different roughness as well as moisture content are analysed. In addition, the signals are taken at 2 different angles to the soil's surface (90° and 70°). For quantification of the roughness, a photographic method (Structure-from-Motion) is applied to generate a detailed DEM and random roughness (RR) is calculated. To characterise the radar signal, different ratios of the reflected channels and polarisations are calculated. The signals show differences for all substrates, also clearly visible between sand and fine rock fragments, despite a wavelength of 1 cm of the electromagnetic waves. A systematic change of the signals with changing roughness is also observed. Measurements show a significant influence of the angle of observation. Soil moisture shows also an influence on the reflected signal, but is quite well differentiable to the effects of the shape of the soil's surface. The results show that polarimetric radar technology may be suitable to characterise the surface of soils, but still faces a big lack of knowledge on how to quantify and differentiate the different signals, how to handle variable observation angles, and finally how to characterise roughness.

Influence of imbalance on distortion in optical push-pull frontends

NASA Astrophysics Data System (ADS)

Hagensen, Morten

1995-04-01

The influence of imbalance on second-order inter-modulation distortion (IMD2) in optical push-pull frontends for Subcarrier Multiplex CATV applications is investigated theoretically and experimentally. The investigation focuses on imbalance introduced in either the photodiode, the push-pull amplifier, or the output balun, and expressions describing the overall IMD2 cancellation efficiency are derived. The developed theory is used to predict the IMD2 cancellation behavior of an optical push-pull fronted. Commercially available PIN photodiodes for CATV purposes and ferrite core transformers are characterised for phase and amplitude balance up to 1 GHz. The overall IMD2 cancellation efficiency of an optical push-pull frontend based on the best of these devices is calculated. The theory is finally verified experimentally with an optical push-pull frontend designed with the characterised photodiode and transformer. The improvement in IMD2 suppression obtained with the push-pull structure relative to a single-ended structure is in average 29 dB across the band from 47-862 MHz. The total IMD2 suppression obtained for the frontend is between 60 dBc and 79 dBc at an average optical input power of 1 mW and with an optical modulation index (OMI) of 35% per carrier in a two-tone setup.

Dark solitons, modulation instability and breathers in a chain of weakly nonlinear oscillators with cyclic symmetry

NASA Astrophysics Data System (ADS)

Fontanela, F.; Grolet, A.; Salles, L.; Chabchoub, A.; Hoffmann, N.

2018-01-01

In the aerospace industry the trend for light-weight structures and the resulting complex dynamic behaviours currently challenge vibration engineers. In many cases, these light-weight structures deviate from linear behaviour, and complex nonlinear phenomena can be expected. We consider a cyclically symmetric system of coupled weakly nonlinear undamped oscillators that could be considered a minimal model for different cyclic and symmetric aerospace structures experiencing large deformations. The focus is on localised vibrations that arise from wave envelope modulation of travelling waves. For the defocussing parameter range of the approximative nonlinear evolution equation, we show the possible existence of dark solitons and discuss their characteristics. For the focussing parameter range, we characterise modulation instability and illustrate corresponding nonlinear breather dynamics. Furthermore, we show that for stronger nonlinearity or randomness in initial conditions, transient breather-type dynamics and decay into bright solitons appear. The findings suggest that significant vibration localisation may arise due to mechanisms of nonlinear modulation dynamics.

The topography of frequency and time representation in primate auditory cortices

PubMed Central

Baumann, Simon; Joly, Olivier; Rees, Adrian; Petkov, Christopher I; Sun, Li; Thiele, Alexander; Griffiths, Timothy D

2015-01-01

Natural sounds can be characterised by their spectral content and temporal modulation, but how the brain is organized to analyse these two critical sound dimensions remains uncertain. Using functional magnetic resonance imaging, we demonstrate a topographical representation of amplitude modulation rate in the auditory cortex of awake macaques. The representation of this temporal dimension is organized in approximately concentric bands of equal rates across the superior temporal plane in both hemispheres, progressing from high rates in the posterior core to low rates in the anterior core and lateral belt cortex. In A1 the resulting gradient of modulation rate runs approximately perpendicular to the axis of the tonotopic gradient, suggesting an orthogonal organisation of spectral and temporal sound dimensions. In auditory belt areas this relationship is more complex. The data suggest a continuous representation of modulation rate across several physiological areas, in contradistinction to a separate representation of frequency within each area. DOI: http://dx.doi.org/10.7554/eLife.03256.001 PMID:25590651

Functional characterisation of metal(loid) processes in planta through the integration of synchrotron techniques and plant molecular biology

PubMed Central

Donner, Erica; Punshon, Tracy; Guerinot, Mary Lou; Lombi, Enzo

2013-01-01

Functional characterisation of the genes regulating metal(loid) homeostasis in plants is a major focus of crop biofortification, phytoremediation, and food security research. This paper focuses on the potential for advancing plant metal(loid) research by combining molecular biology and synchrotron-based techniques. Recent advances in x-ray focussing optics and fluorescence detection have greatly improved the potential of synchrotron techniques for plant science research, allowing metal(loids) to be imaged in vivo in hydrated plant tissues at sub-micron resolution. Laterally resolved metal(loid) speciation can also be determined. By using molecular techniques to probe the location of gene expression and protein localisation and combining it with this synchrotron-derived data, functional information can be effectively and efficiently assigned to specific genes. This paper provides a review of the state of the art in this field, and provides examples as to how synchrotron-based methods can be combined with molecular techniques to facilitate functional characterisation of genes in planta. PMID:22200921

Microscopic characterisation of old mortars from the Santa Maria Church in Evora

DOE Office of Scientific and Technical Information (OSTI.GOV)

Adriano, P., E-mail: padriano@lnec.pt; Santos Silva, A., E-mail: ssilva@lnec.pt; Veiga, R., E-mail: rveiga@lnec.pt

2009-07-15

Evora Cathedral (one of the most emblematic monuments of Evora - Portugal) has suffered several conservation and restoration interventions through the ages, without, however, any type of previous knowledge about mortars and materials used. This work was carried out in order to identify the mortar's composition in different locations, which were attributed to different construction or conservation periods. The characterisation methodology involved a multidisciplinary set of chemical, physical, microstructural and mechanical techniques, and gave special attention to the use of microstructural characterisation techniques, particularly petrographical analysis and scanning electron microscopy for the identification of the mortar's constituents as well asmore » in the evaluation of the state of conservation. The test results showed that two types of aerial binders were used, dolomitic and calcitic limes, the former being predominant. The aggregates used have a siliceous nature and are similar in composition to the granodiorites of the region around Evora. The mortars differ in the aggregate contents and, in some cases, crushed bricks were used as an additive.« less

Detection, breakpoint identification and detailed characterisation of a CNV at the FRA16D site using SNP assays.

PubMed

Winchester, L; Newbury, D F; Monaco, A P; Ragoussis, J

2008-01-01

Copy Number Variants (CNV) and other submicroscopic structural changes are now recognised to be widespread across the human genome. We show that SNP data generated for association study can be utilised for the identification of deletion CNVs. During analysis of data for an SNP association study for Specific Language Impairment (SLI) a deletion was identified. SLI adversely affects the language development of children in the absence of any obvious cause. Previous studies have found linkage to a region on chromosome 16. The deletion was located in a known fragile site FRA16D in intron 5-6 of the WWOX gene (also known as FOR). Changes in the FRA16D site have been previously linked to cancer and are often characterised in cell lines. A long-range PCR assay was used to confirm the existence of the deletion. We also show the breakpoint identification and large-scale characterisation of this CNV in a normal human sample set. Copyright 2009 S. Karger AG, Basel.

KENNEDY SPACE CENTER, FLA. - STS-120 Mission Specialists Piers Sellers and Michael Foreman look at the Japanese Experiment Module (JEM) Pressurized Module located in the Space Station Processing Facility. Known as Kibo, the JEM consists of six components: two research facilities -- the Pressurized Module and Exposed Facility; a Logistics Module attached to each of them; a Remote Manipulator System; and an Inter-Orbit Communication System unit. Kibo also has a scientific airlock through which experiments are transferred and exposed to the external environment of space. The various components of JEM will be assembled in space over the course of three Space Shuttle missions. The STS-120 mission will deliver the second of three Station connecting modules, Node 2, which attaches to the end of U.S. Lab. It will provide attach locations for the JEM, European laboratory, the Centrifuge Accommodation Module and later Multi-Purpose Logistics Modules. The addition of Node 2 will complete the U.S. core of the International Space Station.

NASA Image and Video Library

2003-07-18

KENNEDY SPACE CENTER, FLA. - STS-120 Mission Specialists Piers Sellers and Michael Foreman look at the Japanese Experiment Module (JEM) Pressurized Module located in the Space Station Processing Facility. Known as Kibo, the JEM consists of six components: two research facilities -- the Pressurized Module and Exposed Facility; a Logistics Module attached to each of them; a Remote Manipulator System; and an Inter-Orbit Communication System unit. Kibo also has a scientific airlock through which experiments are transferred and exposed to the external environment of space. The various components of JEM will be assembled in space over the course of three Space Shuttle missions. The STS-120 mission will deliver the second of three Station connecting modules, Node 2, which attaches to the end of U.S. Lab. It will provide attach locations for the JEM, European laboratory, the Centrifuge Accommodation Module and later Multi-Purpose Logistics Modules. The addition of Node 2 will complete the U.S. core of the International Space Station.

Evaluation of Automatically Assigned Job-Specific Interview Modules.

PubMed

Friesen, Melissa C; Lan, Qing; Ge, Calvin; Locke, Sarah J; Hosgood, Dean; Fritschi, Lin; Sadkowsky, Troy; Chen, Yu-Cheng; Wei, Hu; Xu, Jun; Lam, Tai Hing; Kwong, Yok Lam; Chen, Kexin; Xu, Caigang; Su, Yu-Chieh; Chiu, Brian C H; Ip, Kai Ming Dennis; Purdue, Mark P; Bassig, Bryan A; Rothman, Nat; Vermeulen, Roel

2016-08-01

In community-based epidemiological studies, job- and industry-specific 'modules' are often used to systematically obtain details about the subject's work tasks. The module assignment is often made by the interviewer, who may have insufficient occupational hygiene knowledge to assign the correct module. We evaluated, in the context of a case-control study of lymphoid neoplasms in Asia ('AsiaLymph'), the performance of an algorithm that provided automatic, real-time module assignment during a computer-assisted personal interview. AsiaLymph's occupational component began with a lifetime occupational history questionnaire with free-text responses and three solvent exposure screening questions. To assign each job to one of 23 study-specific modules, an algorithm automatically searched the free-text responses to the questions 'job title' and 'product made or services provided by employer' using a list of module-specific keywords, comprising over 5800 keywords in English, Traditional and Simplified Chinese. Hierarchical decision rules were used when the keyword match triggered multiple modules. If no keyword match was identified, a generic solvent module was assigned if the subject responded 'yes' to any of the three solvent screening questions. If these question responses were all 'no', a work location module was assigned, which redirected the subject to the farming, teaching, health professional, solvent, or industry solvent modules or ended the questions for that job, depending on the location response. We conducted a reliability assessment that compared the algorithm-assigned modules to consensus module assignments made by two industrial hygienists for a subset of 1251 (of 11409) jobs selected using a stratified random selection procedure using module-specific strata. Discordant assignments between the algorithm and consensus assignments (483 jobs) were qualitatively reviewed by the hygienists to evaluate the potential information lost from missed questions with using the algorithm-assigned module (none, low, medium, high). The most frequently assigned modules were the work location (33%), solvent (20%), farming and food industry (19%), and dry cleaning and textile industry (6.4%) modules. In the reliability subset, the algorithm assignment had an exact match to the expert consensus-assigned module for 722 (57.7%) of the 1251 jobs. Overall, adjusted for the proportion of jobs in each stratum, we estimated that 86% of the algorithm-assigned modules would result in no information loss, 2% would have low information loss, and 12% would have medium to high information loss. Medium to high information loss occurred for <10% of the jobs assigned the generic solvent module and for 21, 32, and 31% of the jobs assigned the work location module with location responses of 'someplace else', 'factory', and 'don't know', respectively. Other work location responses had ≤8% with medium to high information loss because of redirections to other modules. Medium to high information loss occurred more frequently when a job description matched with multiple keywords pointing to different modules (29-69%, depending on the triggered assignment rule). These evaluations demonstrated that automatically assigned modules can reliably reproduce an expert's module assignment without the direct involvement of an industrial hygienist or interviewer. The feasibility of adapting this framework to other studies will be language- and exposure-specific. Published by Oxford University Press on behalf of the British Occupational Hygiene Society 2016.

Where do uncertainties reside within environmental risk assessments? Expert opinion on uncertainty distributions for pesticide risks to surface water organisms.

PubMed

Skinner, Daniel J C; Rocks, Sophie A; Pollard, Simon J T

2016-12-01

A reliable characterisation of uncertainties can aid uncertainty identification during environmental risk assessments (ERAs). However, typologies can be implemented inconsistently, causing uncertainties to go unidentified. We present an approach based on nine structured elicitations, in which subject-matter experts, for pesticide risks to surface water organisms, validate and assess three dimensions of uncertainty: its level (the severity of uncertainty, ranging from determinism to ignorance); nature (whether the uncertainty is epistemic or aleatory); and location (the data source or area in which the uncertainty arises). Risk characterisation contains the highest median levels of uncertainty, associated with estimating, aggregating and evaluating the magnitude of risks. Regarding the locations in which uncertainty is manifest, data uncertainty is dominant in problem formulation, exposure assessment and effects assessment. The comprehensive description of uncertainty described will enable risk analysts to prioritise the required phases, groups of tasks, or individual tasks within a risk analysis according to the highest levels of uncertainty, the potential for uncertainty to be reduced or quantified, or the types of location-based uncertainty, thus aiding uncertainty prioritisation during environmental risk assessments. In turn, it is expected to inform investment in uncertainty reduction or targeted risk management action. Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.

Plasmodium P-Type Cyclin CYC3 Modulates Endomitotic Growth during Oocyst Development in Mosquitoes

PubMed Central

Ferguson, David J. P.; Kaindama, Mbinda L.; Brusini, Lorenzo; Joshi, Nimitray; Rchiad, Zineb; Brady, Declan; Guttery, David S.; Wheatley, Sally P.; Yamano, Hiroyuki; Holder, Anthony A.; Pain, Arnab; Wickstead, Bill; Tewari, Rita

2015-01-01

Cell-cycle progression and cell division in eukaryotes are governed in part by the cyclin family and their regulation of cyclin-dependent kinases (CDKs). Cyclins are very well characterised in model systems such as yeast and human cells, but surprisingly little is known about their number and role in Plasmodium, the unicellular protozoan parasite that causes malaria. Malaria parasite cell division and proliferation differs from that of many eukaryotes. During its life cycle it undergoes two types of mitosis: endomitosis in asexual stages and an extremely rapid mitotic process during male gametogenesis. Both schizogony (producing merozoites) in host liver and red blood cells, and sporogony (producing sporozoites) in the mosquito vector, are endomitotic with repeated nuclear replication, without chromosome condensation, before cell division. The role of specific cyclins during Plasmodium cell proliferation was unknown. We show here that the Plasmodium genome contains only three cyclin genes, representing an unusual repertoire of cyclin classes. Expression and reverse genetic analyses of the single Plant (P)-type cyclin, CYC3, in the rodent malaria parasite, Plasmodium berghei, revealed a cytoplasmic and nuclear location of the GFP-tagged protein throughout the lifecycle. Deletion of cyc3 resulted in defects in size, number and growth of oocysts, with abnormalities in budding and sporozoite formation. Furthermore, global transcript analysis of the cyc3-deleted and wild type parasites at gametocyte and ookinete stages identified differentially expressed genes required for signalling, invasion and oocyst development. Collectively these data suggest that cyc3 modulates oocyst endomitotic development in Plasmodium berghei. PMID:26565797

Evaluation of Automatically Assigned Job-Specific Interview Modules

PubMed Central

Friesen, Melissa C.; Lan, Qing; Ge, Calvin; Locke, Sarah J.; Hosgood, Dean; Fritschi, Lin; Sadkowsky, Troy; Chen, Yu-Cheng; Wei, Hu; Xu, Jun; Lam, Tai Hing; Kwong, Yok Lam; Chen, Kexin; Xu, Caigang; Su, Yu-Chieh; Chiu, Brian C. H.; Ip, Kai Ming Dennis; Purdue, Mark P.; Bassig, Bryan A.; Rothman, Nat; Vermeulen, Roel

2016-01-01

Objective: In community-based epidemiological studies, job- and industry-specific ‘modules’ are often used to systematically obtain details about the subject’s work tasks. The module assignment is often made by the interviewer, who may have insufficient occupational hygiene knowledge to assign the correct module. We evaluated, in the context of a case–control study of lymphoid neoplasms in Asia (‘AsiaLymph’), the performance of an algorithm that provided automatic, real-time module assignment during a computer-assisted personal interview. Methods: AsiaLymph’s occupational component began with a lifetime occupational history questionnaire with free-text responses and three solvent exposure screening questions. To assign each job to one of 23 study-specific modules, an algorithm automatically searched the free-text responses to the questions ‘job title’ and ‘product made or services provided by employer’ using a list of module-specific keywords, comprising over 5800 keywords in English, Traditional and Simplified Chinese. Hierarchical decision rules were used when the keyword match triggered multiple modules. If no keyword match was identified, a generic solvent module was assigned if the subject responded ‘yes’ to any of the three solvent screening questions. If these question responses were all ‘no’, a work location module was assigned, which redirected the subject to the farming, teaching, health professional, solvent, or industry solvent modules or ended the questions for that job, depending on the location response. We conducted a reliability assessment that compared the algorithm-assigned modules to consensus module assignments made by two industrial hygienists for a subset of 1251 (of 11409) jobs selected using a stratified random selection procedure using module-specific strata. Discordant assignments between the algorithm and consensus assignments (483 jobs) were qualitatively reviewed by the hygienists to evaluate the potential information lost from missed questions with using the algorithm-assigned module (none, low, medium, high). Results: The most frequently assigned modules were the work location (33%), solvent (20%), farming and food industry (19%), and dry cleaning and textile industry (6.4%) modules. In the reliability subset, the algorithm assignment had an exact match to the expert consensus-assigned module for 722 (57.7%) of the 1251 jobs. Overall, adjusted for the proportion of jobs in each stratum, we estimated that 86% of the algorithm-assigned modules would result in no information loss, 2% would have low information loss, and 12% would have medium to high information loss. Medium to high information loss occurred for <10% of the jobs assigned the generic solvent module and for 21, 32, and 31% of the jobs assigned the work location module with location responses of ‘someplace else’, ‘factory’, and ‘don’t know’, respectively. Other work location responses had ≤8% with medium to high information loss because of redirections to other modules. Medium to high information loss occurred more frequently when a job description matched with multiple keywords pointing to different modules (29–69%, depending on the triggered assignment rule). Conclusions: These evaluations demonstrated that automatically assigned modules can reliably reproduce an expert’s module assignment without the direct involvement of an industrial hygienist or interviewer. The feasibility of adapting this framework to other studies will be language- and exposure-specific. PMID:27250109

Neuropeptide modulation of addiction: focus on galanin.

PubMed

Genders, Shannyn G; Scheller, Karlene J; Djouma, Elvan

2018-06-24

Addiction is a chronic, relapsing disorder characterised by the use of a substance or act to the point of compulsion. There are a number of medical treatments available for the intervention of these disorders, however, the effectiveness of current therapeutics is far from adequate. Neuropeptides are known to modulate addictive behaviours and may provide new therapeutic targets for the treatment of substance abuse. Accumulating evidence has suggested galanin as a potential important neuromodulator of addiction. Both human genetic studies and animal models have highlighted a role for this neuropeptide in affective disorders, as well as alcohol, nicotine, and opiate dependence. This review highlights the role of galanin and other primary neuropeptides implicated in modulating addiction to different drugs of abuse. Orexin, relaxin-3, corticotrophin-releasing factor, dynorphin and enkephalin, are also discussed given their involvement in mediating reward-seeking behaviour. Copyright © 2018. Published by Elsevier Ltd.

U.S. Laboratory Module (Destiny) for the International Space Station

NASA Technical Reports Server (NTRS)

1997-01-01

In this photograph, the U.S. Laboratory Module (also called Destiny) for the International Space Station (ISS) is shown under construction in the West High Bay of the Space Station manufacturing facility (building 4708) at the Marshall Space Flight Center. The U.S. Laboratory module is the centerpiece of the ISS, where science experiments will be performed in the near-zero gravity of space. The Destiny Module was launched aboard the Space Shuttle orbiter Atlantis (STS-98 mission) on February 7, 2001. The aluminum module is 8.5 meters (28 feet) long and 4.3 meters (14 feet) in diameter. The laboratory consists of three cylindrical sections and two endcones with hatches that will be mated to other station components. A 50.9-centimeter- (20-inch-) diameter window is located on one side of the center module segment. This pressurized module is designed to accommodate pressurized payloads. It has a capacity of 24 rack locations, and payload racks will occupy 13 locations especially designed to support experiments. The ISS is a multidisciplinary laboratory, technology test bed, and observatory that will provide unprecedented undertakings in scientific, technological, and international experimentation.

U.S. Laboratory Module (Destiny) for the International Space Station

NASA Technical Reports Server (NTRS)

1998-01-01

This photograph shows the U.S. Laboratory Module (also called Destiny) for the International Space Station (ISS), in the Space Station manufacturing facility at the Marshall Space Flight Center, being readied for shipment to the Kennedy Space Center. The U.S. Laboratory module is the centerpiece of the ISS, where science experiments will be performed in the near-zero gravity of space. The Destiny Module was launched aboard the Space Shuttle orbiter Atlantis (STS-67 mission) on February 7, 2001. The aluminum module is 8.5 meters (28 feet) long and 4.3 meters (14 feet) in diameter. The laboratory consists of three cylindrical sections and two endcones with hatches that will be mated to other station components. A 50.9-centimeter- (20-inch-) diameter window is located on one side of the center module segment. This pressurized module is designed to accommodate pressurized payloads. It has a capacity of 24 rack locations, and payload racks will occupy 13 locations especially designed to support experiments. The ISS is a multidisciplinary laboratory, technology test bed, and observatory that will provide unprecedented undertakings in scientific, technological, and international experimentation.

U.S. Laboratory Module (Destiny) for the International Space Station

NASA Technical Reports Server (NTRS)

1997-01-01

This photograph shows the U.S. Laboratory Module (also called Destiny) for the International Space Station (ISS), under construction in the Space Station manufacturing facility at the Marshall Space Flight Center. The U.S. Laboratory module is the centerpiece of the ISS, where science experiments will be performed in the near-zero gravity of space. The Destiny Module was launched aboard the Space Shuttle orbiter Atlantis (STS-67 mission) on February 7, 2001. The aluminum module is 8.5 meters (28 feet) long and 4.3 meters (14 feet) in diameter. The laboratory consists of three cylindrical sections and two end cones with hatches that will be mated to other station components. A 50.9-centimeter- (20-inch-) diameter window is located on one side of the center module segment. This pressurized module is designed to accommodate pressurized payloads. It has a capacity of 24 rack locations, and payload racks will occupy 13 locations especially designed to support experiments. The ISS is a multidisciplinary laboratory, technology test bed, and observatory that will provide unprecedented undertakings in scientific, technological, and international experimentation.

Hydrogeochemical characterisation of groundwater in a small watershed in a discontinuous permafrost zone.

NASA Astrophysics Data System (ADS)

Cochand, Marion; Molson, John; Barth, Johannes A. C.; van Geldern, Robert; Lemieux, Jean-Michel; Fortier, Richard; Therrien, René

2017-04-01

Impacts of climate change can already be seen in northern regions. However, the influence of increasing temperature and permafrost degradation on groundwater dynamics is still poorly understood. This study aims to improve knowledge on hydrogeological interactions in degrading permafrost environments using hydrogeochemical characterisation of groundwater. This study is being conducted in a small 2-km2 watershed, in a discontinuous permafrost zone located close to the Inuit community of Umiujaq, on the eastern shore of Hudson Bay in northern Québec, Canada. Two aquifers are being investigated, an unconfined shallow sandy aquifer located in the upper part of the watershed, and a deeper confined aquifer in sands and gravels located below the permafrost mounds. Precipitation, stream and surface water as well as ice-rich permafrost lenses were also sampled during field investigations. Various hydrogeochemical tracers including major ions, water stable isotopes (δ18OH2O and δ2HH2O), carbon phases (DIC, DOC, POC), their stable carbon isotopes (δ13C) and dating tracers (radiocarbon, tritium-helium and CFC/SF6) were analyzed. This characterisation has contributed to further understanding groundwater origin, evolution and residence time in the watershed. Preliminary results show that groundwater has a mainly Ca-HCO3 geochemical signature, typical for young and poorly evolved water. Furthermore, sample mineralisation is low, and is likely linked to limited bedrock weathering caused by short residence times, slow reaction rates as well as low levels of dissolved CO2 due to suppressed biological activity in the catchment. Inter-annual variation of major ions in the deeper aquifer is low. All groundwater samples have significant tritium concentrations, around 8.5 TU, reflecting modern recharge. Ice-rich permafrost lenses within the top four meters of permafrost have a water stable isotope signature close to modern precipitation and groundwater. This indicates that either recharge conditions of permafrost ice were similar to current conditions, or freeze-thaw cycles have drawn modern water into the permafrost mounds. The stream appears to be fed by groundwater exfiltrating at the base of permafrost mounds in the lower part of the watershed. Linking this hydrogeochemical characterisation to groundwater and thermal modelling at the watershed and permafrost mound scales will improve our knowledge on hydrogeological interactions in degrading permafrost environments.

Ground Penetrating Radar as a Contextual Sensor for Multi-Sensor Radiological Characterisation

PubMed Central

Ukaegbu, Ikechukwu K.; Gamage, Kelum A. A.

2017-01-01

Radioactive sources exist in environments or contexts that influence how they are detected and localised. For instance, the context of a moving source is different from a stationary source because of the effects of motion. The need to incorporate this contextual information in the radiation detection and localisation process has necessitated the integration of radiological and contextual sensors. The benefits of the successful integration of both types of sensors is well known and widely reported in fields such as medical imaging. However, the integration of both types of sensors has also led to innovative solutions to challenges in characterising radioactive sources in non-medical applications. This paper presents a review of such recent applications. It also identifies that these applications mostly use visual sensors as contextual sensors for characterising radiation sources. However, visual sensors cannot retrieve contextual information about radioactive wastes located in opaque environments encountered at nuclear sites, e.g., underground contamination. Consequently, this paper also examines ground-penetrating radar (GPR) as a contextual sensor for characterising this category of wastes and proposes several ways of integrating data from GPR and radiological sensors. Finally, it demonstrates combined GPR and radiation imaging for three-dimensional localisation of contamination in underground pipes using radiation transport and GPR simulations. PMID:28387706

KENNEDY SPACE CENTER, FLA. - An overhead crane in the Space Station Processing Facility lifts the U.S. Node 2 out of its shipping container. The node will be moved to a workstand. The second of three connecting modules on the International Space Station, the Italian-built Node 2 attaches to the end of the U.S. Lab and provides attach locations for the Japanese laboratory, European laboratory, the Centrifuge Accommodation Module and, later, Multipurpose Logistics Modules. It will provide the primary docking location for the Shuttle when a pressurized mating adapter is attached to Node 2. Installation of the module will complete the U.S. Core of the ISS. Node 2 is the designated payload for mission STS-120. No orbiter or launch date has been determined yet.

NASA Image and Video Library

2003-06-03

KENNEDY SPACE CENTER, FLA. - An overhead crane in the Space Station Processing Facility lifts the U.S. Node 2 out of its shipping container. The node will be moved to a workstand. The second of three connecting modules on the International Space Station, the Italian-built Node 2 attaches to the end of the U.S. Lab and provides attach locations for the Japanese laboratory, European laboratory, the Centrifuge Accommodation Module and, later, Multipurpose Logistics Modules. It will provide the primary docking location for the Shuttle when a pressurized mating adapter is attached to Node 2. Installation of the module will complete the U.S. Core of the ISS. Node 2 is the designated payload for mission STS-120. No orbiter or launch date has been determined yet.

View of damaged Apollo 13 Service Module from the Lunar/Command Modules

NASA Image and Video Library

1970-04-17

AS13-59-8501 (17 April 1970) --- This view of the severely damaged Apollo 13 Service Module (SM) was photographed from the Lunar Module/Command Module (LM/CM) following SM jettisoning. As seen here, an entire panel on the SM was blown away by the apparent explosion of oxygen tank number two located in Sector 4 of the SM. Two of the three fuel cells are visible just forward (above) the heavily damaged area. Three fuel cells, two oxygen tanks, and two hydrogen tanks are located in Sector 4. The damaged area is located above the S-Band high gain antenna. Nearest the camera is the Service Propulsion System (SPS) engine and nozzle. The damage to the SM caused the Apollo 13 crew men to use the LM as a "lifeboat." The LM was jettisoned just prior to Earth re-entry by the CM.

Neem oil nanoemulsions: characterisation and antioxidant activity.

PubMed

Rinaldi, Federica; Hanieh, Patrizia Nadia; Longhi, Catia; Carradori, Simone; Secci, Daniela; Zengin, Gokhan; Ammendolia, Maria Grazia; Mattia, Elena; Del Favero, Elena; Marianecci, Carlotta; Carafa, Maria

2017-12-01

The aim of the present work is to develop nanoemulsions (NEs), nanosized emulsions, manufactured for improving the delivery of active pharmaceutical ingredients. In particular, nanoemulsions composed of Neem seed oil, contain rich bioactive components, and Tween 20 as nonionic surfactant were prepared. A mean droplet size ranging from 10 to 100 nm was obtained by modulating the oil/surfactant ratio. Physicochemical characterisation was carried out evaluating size, ζ-potential, microviscosity, polarity and turbidity of the external shell and morphology, along with stability in simulated cerebrospinal fluid (CSF), activity of Neem oil alone and in NEs, HEp-2 cell interaction and cytotoxicity studies. This study confirms the formation of NEs by Tween 20 and Neem oil at different weight ratios with small and homogenous dimensions. The antioxidant activity of Neem oil alone and in NEs was comparable, whereas its cytotoxicity was strongly reduced when loaded in NEs after interaction with HEp-2 cells.

Schools, Teachers and Community: Cultivating the Conditions for Engaged Student Learning

ERIC Educational Resources Information Center

Hardy, Ian; Grootenboer, Peter

2013-01-01

This paper reveals the nature of the actions, discussions and relationships which characterised teachers' and associated school personnel's efforts to engage poor and refugee students through a community garden located in a school in a low socio-economic urban area in south-east Queensland, Australia. These actions, discussions and relationships…

Trichomonas vaginalis ribosomal RNA: identification and characterisation of the transcription promoter and terminator sequences.

PubMed

Franco, Bernardo; Hernández, Roberto; López-Villaseñor, Imelda

2012-09-01

Trichomonas vaginalis is a parasitic protozoan of both medical and biological relevance. Transcriptional studies in this organism have focused mainly on type II pol promoters, whereas the elements necessary for transcription by polI or polIII have not been investigated. Here, with the aid of a transient transcription system, we characterised the rDNA intergenic region, defining both the promoter and the terminator sequences required for transcription. We defined the promoter as a compact region of approximately 180 bp. We also identified a potential upstream control element (UCE) that was located 80 bp upstream of the transcription start point (TSP). A transcription termination element was identified within a 34 bp region that was located immediately downstream of the 28S coding sequence. The function of this element depends upon polarity and the presence of both a stretch of uridine residues (U's) and a hairpin structure in the transcript. Our observations provide a strong basis for the study of DNA recognition by the polI transcriptional machinery in this early divergent organism. Copyright © 2012 Elsevier B.V. All rights reserved.

Marine asset security and tracking (MAST) system

DOEpatents

Hanson, Gregory Richard [Clinton, TN; Smith, Stephen Fulton [Loudon, TN; Moore, Michael Roy [Corryton, TN; Dobson, Eric Lesley [Charleston, SC; Blair, Jeffrey Scott [Charleston, SC; Duncan, Christopher Allen [Marietta, GA; Lenarduzzi, Roberto [Knoxville, TN

2008-07-01

Methods and apparatus are described for marine asset security and tracking (MAST). A method includes transmitting identification data, location data and environmental state sensor data from a radio frequency tag. An apparatus includes a radio frequency tag that transmits identification data, location data and environmental state sensor data. Another method includes transmitting identification data and location data from a radio frequency tag using hybrid spread-spectrum modulation. Another apparatus includes a radio frequency tag that transmits both identification data and location data using hybrid spread-spectrum modulation.

Characterisation of baroreflex sensitivity of recreational ultra-endurance athletes.

PubMed

Foulds, Heather J A; Cote, Anita T; Phillips, Aaron A; Charlesworth, Sarah A; Bredin, Shannon S D; Burr, Jamie F; Drury, Chipman Taylor; Ngai, Shirley; Fougere, Renee J; Ivey, Adam C; Warburton, Darren E R

2014-01-01

Altered autonomic function has been identified following ultra-endurance event participation among elite world-class athletes. Despite dramatic increases in recreational athlete participation in these ultra-endurance events, the physiological effects on these athletes are less known. This investigation sought to characterise changes in surrogate measures of autonomic function: heart rate variability (HRV), blood pressure variability (BPV) and baroreceptor sensitivity (BRS) following ultra-endurance race participation. Further, we sought to compare baseline measures among ultra-endurance athletes and recreationally active controls not participating in the ultra-endurance race. Recreational ultra-endurance athletes (n = 25, 44.6 ± 8.2 years, 8 females) and recreationally active age, sex and body mass index matched controls (n = 25) were evaluated. Measurements of HRV, BPV and BRS were collected pre- and post-race for recreational ultra-endurance athletes and at baseline, for recreationally active controls. Post-race, ultra-endurance athletes demonstrated significantly greater sympathetic modulation [low frequency (LF) power HRV: 50.3 ± 21.6 normalised units (n.u.) to 65.9 ± 20.4 n.u., p = 0.01] and significantly lower parasympathetic modulation [high frequency (HF) power HRV: 45.0 ± 22.4 n.u. to 23.9 ± 13.1 n.u., p < 0.001] and BRS. Baseline measurements BRS (spectral: 13.96 ± 10.82 ms·mmHg(-1) vs. 11.39 ± 5.33 ms·mmHg(-1)) were similar among recreational ultra-endurance athletes and recreationally active controls, though recreational ultra-endurance athletes demonstrated greater parasympathetic modulation of some HRV and BPV measures. Recreational ultra-endurance athletes experienced increased sympathetic tone and declines in BRS post-race, similar to previously reported elite world-class ultra-endurance athletes, though still within normal population ranges.

A DFT study of the mechanism and the regioselectivity of [3 + 2] cycloaddition reactions of nitrile oxides with α,β-acetylenic aldehyde

NASA Astrophysics Data System (ADS)

Sobhi, Chafia; Nacereddine, Abdelmalek Khorief; Nasri, Lilia; Lechtar, Zohra; Djerourou, Abdelhafid

2016-11-01

A DFT study of the (32CA) reaction of a series of some nitrile oxides with electron-deficient alkyne (3-phenylpropionlaldehyde) in gas phase and in toluene has been carried out using B3LYP functional with 6-31G(d) basis set. Two reactive channels 4- and 5-associated with the two regioisomeric modes have been located and characterised. These 32CA reactions are characterised by a low asynchronous one-step mechanism with a low-polar character. Analysis of the DFT reactivity indices indicates that the nucleophilic centre of the different nitrile oxides accounts for the 4-regioselectivity. Our calculations are in a good agreement with the experimental findings.

Practice-induced and sequential modulations of the Simon effect.

PubMed

Soetens, Eric; Maetens, Kathleen; Zeischka, Peter

2010-05-01

People react more quickly and more accurately to stimuli presented in locations corresponding to the response, as compared with noncorresponding locations, even when stimulus location is irrelevant (Simon effect [SE]). The explanation that SEs are caused by the automatic priming of a corresponding response has been questioned, because of the many exceptions to the effect. We replicated practice-induced and sequential modulations of the SE in two experiments--first, by training participants with blocks of location-relevant stimuli, and second, by mixing location-relevant and location-irrelevant trials. The decrease of the SE with incompatible training was relatively permanent in the blocked experiment, whereas the effect was temporary in the mixed experiment. The difference was caused by a more permanent reversal of the SE after incongruent trials, showing that sequential modulations depend on long-term practice effects. We suggest that there is a formation of a contralateral long-term memory stimulus-response link in blocked conditions and that short-term and long-term memory links are primed by preceding events.

Continuous wavelet transform analysis and modal location analysis acoustic emission source location for nuclear piping crack growth monitoring

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mohd, Shukri; Holford, Karen M.; Pullin, Rhys

2014-02-12

Source location is an important feature of acoustic emission (AE) damage monitoring in nuclear piping. The ability to accurately locate sources can assist in source characterisation and early warning of failure. This paper describe the development of a novelAE source location technique termed 'Wavelet Transform analysis and Modal Location (WTML)' based on Lamb wave theory and time-frequency analysis that can be used for global monitoring of plate like steel structures. Source location was performed on a steel pipe of 1500 mm long and 220 mm outer diameter with nominal thickness of 5 mm under a planar location test setup usingmore » H-N sources. The accuracy of the new technique was compared with other AE source location methods such as the time of arrival (TOA) techniqueand DeltaTlocation. Theresults of the study show that the WTML method produces more accurate location resultscompared with TOA and triple point filtering location methods. The accuracy of the WTML approach is comparable with the deltaT location method but requires no initial acoustic calibration of the structure.« less

KENNEDY SPACE CENTER, FLA. - Workers in the Space Station Processing Facility observe consoles during a Multi-Element Integrated Test (MEIT) of the U.S. Node 2 and the Japanese Experiment Module (JEM). Node 2 attaches to the end of the U.S. Lab on the ISS and provides attach locations for the Japanese laboratory, European laboratory, the Centrifuge Accommodation Module and, eventually, Multipurpose Logistics Modules. It will provide the primary docking location for the Shuttle when a pressurized mating adapter is attached to Node 2. Installation of the module will complete the U.S. Core of the ISS. The JEM, developed by the National Space Development Agency of Japan (NASDA), is Japan's primary contribution to the Station. It will enhance the unique research capabilities of the orbiting complex by providing an additional environment for astronauts to conduct science experiments.

NASA Image and Video Library

2003-09-03

KENNEDY SPACE CENTER, FLA. - Workers in the Space Station Processing Facility observe consoles during a Multi-Element Integrated Test (MEIT) of the U.S. Node 2 and the Japanese Experiment Module (JEM). Node 2 attaches to the end of the U.S. Lab on the ISS and provides attach locations for the Japanese laboratory, European laboratory, the Centrifuge Accommodation Module and, eventually, Multipurpose Logistics Modules. It will provide the primary docking location for the Shuttle when a pressurized mating adapter is attached to Node 2. Installation of the module will complete the U.S. Core of the ISS. The JEM, developed by the National Space Development Agency of Japan (NASDA), is Japan's primary contribution to the Station. It will enhance the unique research capabilities of the orbiting complex by providing an additional environment for astronauts to conduct science experiments.

KENNEDY SPACE CENTER, FLA. - Technicians in the Space Station Processing Facility work on a Multi-Element Integrated Test (MEIT) of the U.S. Node 2 and the Japanese Experiment Module (JEM). Node 2 attaches to the end of the U.S. Lab on the ISS and provides attach locations for the Japanese laboratory, European laboratory, the Centrifuge Accommodation Module and, eventually, Multipurpose Logistics Modules. It will provide the primary docking location for the Shuttle when a pressurized mating adapter is attached to Node 2. Installation of the module will complete the U.S. Core of the ISS. The JEM, developed by the National Space Development Agency of Japan (NASDA), is Japan's primary contribution to the Station. It will enhance the unique research capabilities of the orbiting complex by providing an additional environment for astronauts to conduct science experiments.

NASA Image and Video Library

2003-09-03

KENNEDY SPACE CENTER, FLA. - Technicians in the Space Station Processing Facility work on a Multi-Element Integrated Test (MEIT) of the U.S. Node 2 and the Japanese Experiment Module (JEM). Node 2 attaches to the end of the U.S. Lab on the ISS and provides attach locations for the Japanese laboratory, European laboratory, the Centrifuge Accommodation Module and, eventually, Multipurpose Logistics Modules. It will provide the primary docking location for the Shuttle when a pressurized mating adapter is attached to Node 2. Installation of the module will complete the U.S. Core of the ISS. The JEM, developed by the National Space Development Agency of Japan (NASDA), is Japan's primary contribution to the Station. It will enhance the unique research capabilities of the orbiting complex by providing an additional environment for astronauts to conduct science experiments.

KENNEDY SPACE CENTER, FLA. - An overhead crane in the Space Station Processing Facility is attached to the U.S. Node 2 to lift it out of its shipping container. The node will be moved to a workstand. The second of three connecting modules on the International Space Station, the Italian-built Node 2 attaches to the end of the U.S. Lab and provides attach locations for the Japanese laboratory, European laboratory, the Centrifuge Accommodation Module and, later, Multipurpose Logistics Modules. It will provide the primary docking location for the Shuttle when a pressurized mating adapter is attached to Node 2. Installation of the module will complete the U.S. Core of the ISS. Node 2 is the designated payload for mission STS-120. No orbiter or launch date has been determined yet.

NASA Image and Video Library

2003-06-03

KENNEDY SPACE CENTER, FLA. - An overhead crane in the Space Station Processing Facility is attached to the U.S. Node 2 to lift it out of its shipping container. The node will be moved to a workstand. The second of three connecting modules on the International Space Station, the Italian-built Node 2 attaches to the end of the U.S. Lab and provides attach locations for the Japanese laboratory, European laboratory, the Centrifuge Accommodation Module and, later, Multipurpose Logistics Modules. It will provide the primary docking location for the Shuttle when a pressurized mating adapter is attached to Node 2. Installation of the module will complete the U.S. Core of the ISS. Node 2 is the designated payload for mission STS-120. No orbiter or launch date has been determined yet.

Operation and Maintenance Manual, TECS 18.

DTIC Science & Technology

1978-11-01

width modulated variable output voltage and frequency using a three-phase transistor bridge circuit . Reduced power line electromagnetic interference...Description 3-1 Section II. Circuit Fundamentals 3-1 Section III. System Description 3-2 CHAPTER 4. Protection and Maintenance 4-1 Section I. Internal...Number I-la TECS 18 Electronic Module Location-Evaporator Side 1-3 1-lb TECS 18 Electronic Module Location-Condenser Side 1-4 1-2 Remote Control Panel 1-5

The International Society for Extracellular Vesicles launches the first massive open online course on extracellular vesicles.

PubMed

Lässer, Cecilia; Théry, Clotilde; Buzás, Edit I; Mathivanan, Suresh; Zhao, Weian; Gho, Yong Song; Lötvall, Jan

2016-01-01

The International Society for Extracellular Vesicles (ISEV) has organised its first educational online course for students and beginners in the field of extracellular vesicles (EVs). This course, "Basics of Extracellular Vesicles," uses recorded lectures from experts in the field and will be open for an unlimited number of participants. The course is divided into 5 modules and can be accessed at www.coursera.org/learn/extracellular-vesicles. The first module is an introduction to the field covering the nomenclature and history of EVs. Module 2 focuses on the biogenesis and uptake mechanisms of EVs, as well as their RNA, protein and lipid cargo. Module 3 covers the collection and processing of cell culture media and body fluids such as blood, breast milk, cerebrospinal fluid and urine prior to isolation of EVs. Modules 4 and 5 present different isolation methods and characterisation techniques utilised in the EV field. Here, differential ultracentrifugation, size-exclusion chromatography, density gradient centrifugation, kit-based precipitation, electron microscopy, cryo-electron microscopy, flow cytometry, atomic-force microscopy and nanoparticle-tracking analysis are covered. This first massive open online course (MOOC) on EVs was launched on 15 August 2016 at the platform "Coursera" and is free of charge.

Cosmonaut Gidzenko Near Hatch Between Unity and Destiny

NASA Technical Reports Server (NTRS)

2001-01-01

Cosmonaut Yuri P. Gidzenko, Expedition One Soyuz commander, stands near the hatch leading from the Unity node into the newly-attached Destiny laboratory aboard the International Space Station (ISS). The Node 1, or Unity, serves as a cornecting passageway to Space Station modules. The U.S.-built Unity module was launched aboard the Orbiter Endeavour (STS-88 mission) on December 4, 1998, and connected to Zarya, the Russian-built Functional Cargo Block (FGB). The U.S. Laboratory (Destiny) module is the centerpiece of the ISS, where science experiments will be performed in the near-zero gravity in space. The Destiny Module was launched aboard the Space Shuttle Orbiter Atlantis (STS-98 mission) on February 7, 2001. The aluminum module is 8.5 meters (28 feet) long and 4.3 meters (14 feet) in diameter. The laboratory consists of three cylindrical sections and two endcones with hatches that will be mated to other station components. A 50.9-centimeter- (20-inch-) diameter window is located on one side of the center module segment. This pressurized module is designed to accommodate pressurized payloads. It has a capacity of 24 rack locations, and payload racks will occupy 13 locations especially designed to support experiments.

International Space Station (ISS)

NASA Image and Video Library

2001-02-10

Cosmonaut Yuri P. Gidzenko, Expedition One Soyuz commander, stands near the hatch leading from the Unity node into the newly-attached Destiny laboratory aboard the International Space Station (ISS). The Node 1, or Unity, serves as a cornecting passageway to Space Station modules. The U.S.-built Unity module was launched aboard the Orbiter Endeavour (STS-88 mission) on December 4, 1998, and connected to Zarya, the Russian-built Functional Cargo Block (FGB). The U.S. Laboratory (Destiny) module is the centerpiece of the ISS, where science experiments will be performed in the near-zero gravity in space. The Destiny Module was launched aboard the Space Shuttle Orbiter Atlantis (STS-98 mission) on February 7, 2001. The aluminum module is 8.5 meters (28 feet) long and 4.3 meters (14 feet) in diameter. The laboratory consists of three cylindrical sections and two endcones with hatches that will be mated to other station components. A 50.9-centimeter- (20-inch-) diameter window is located on one side of the center module segment. This pressurized module is designed to accommodate pressurized payloads. It has a capacity of 24 rack locations, and payload racks will occupy 13 locations especially designed to support experiments.

International Space Station (ISS)

NASA Image and Video Library

1998-11-01

This photograph shows the U.S. Laboratory Module (also called Destiny) for the International Space Station (ISS), in the Space Station manufacturing facility at the Marshall Space Flight Center, being readied for shipment to the Kennedy Space Center. The U.S. Laboratory module is the centerpiece of the ISS, where science experiments will be performed in the near-zero gravity of space. The Destiny Module was launched aboard the Space Shuttle orbiter Atlantis (STS-67 mission) on February 7, 2001. The aluminum module is 8.5 meters (28 feet) long and 4.3 meters (14 feet) in diameter. The laboratory consists of three cylindrical sections and two endcones with hatches that will be mated to other station components. A 50.9-centimeter- (20-inch-) diameter window is located on one side of the center module segment. This pressurized module is designed to accommodate pressurized payloads. It has a capacity of 24 rack locations, and payload racks will occupy 13 locations especially designed to support experiments. The ISS is a multidisciplinary laboratory, technology test bed, and observatory that will provide unprecedented undertakings in scientific, technological, and international experimentation.

International Space Station (ISS)

NASA Image and Video Library

1997-01-01

In this photograph, the U.S. Laboratory Module (also called Destiny) for the International Space Station (ISS) is shown under construction in the West High Bay of the Space Station manufacturing facility (building 4708) at the Marshall Space Flight Center. The U.S. Laboratory module is the centerpiece of the ISS, where science experiments will be performed in the near-zero gravity of space. The Destiny Module was launched aboard the Space Shuttle orbiter Atlantis (STS-98 mission) on February 7, 2001. The aluminum module is 8.5 meters (28 feet) long and 4.3 meters (14 feet) in diameter. The laboratory consists of three cylindrical sections and two endcones with hatches that will be mated to other station components. A 50.9-centimeter- (20-inch-) diameter window is located on one side of the center module segment. This pressurized module is designed to accommodate pressurized payloads. It has a capacity of 24 rack locations, and payload racks will occupy 13 locations especially designed to support experiments. The ISS is a multidisciplinary laboratory, technology test bed, and observatory that will provide unprecedented undertakings in scientific, technological, and international experimentation.

International Space Station (ISS)

NASA Image and Video Library

1997-11-01

In this photograph, the U.S. Laboratory Module (also called Destiny) for the International Space Station (ISS) is shown under construction in the West High Bay of the Space Station manufacturing facility (building 4708) at the Marshall Space Flight Center. The U.S. Laboratory module is the centerpiece of the ISS, where science experiments will be performed in the near-zero gravity of space. The Destiny Module was launched aboard the Space Shuttle orbiter Atlantis (STS-98 mission) on February 7, 2001. The aluminum module is 8.5 meters (28 feet) long and 4.3 meters (14 feet) in diameter. The laboratory consists of three cylindrical sections and two endcones with hatches that will be mated to other station components. A 50.9-centimeter- (20-inch-) diameter window is located on one side of the center module segment. This pressurized module is designed to accommodate pressurized payloads. It has a capacity of 24 rack locations, and payload racks will occupy 13 locations especially designed to support experiments. The ISS is a multidisciplinary laboratory, technology test bed, and observatory that will provide unprecedented undertakings in scientific, technological, and international experimentation.

International Space Station (ISS)

NASA Image and Video Library

1997-11-26

This photograph shows the U.S. Laboratory Module (also called Destiny) for the International Space Station (ISS), under construction in the Space Station manufacturing facility at the Marshall Space Flight Center. The U.S. Laboratory module is the centerpiece of the ISS, where science experiments will be performed in the near-zero gravity of space. The Destiny Module was launched aboard the Space Shuttle orbiter Atlantis (STS-67 mission) on February 7, 2001. The aluminum module is 8.5 meters (28 feet) long and 4.3 meters (14 feet) in diameter. The laboratory consists of three cylindrical sections and two end cones with hatches that will be mated to other station components. A 50.9-centimeter- (20-inch-) diameter window is located on one side of the center module segment. This pressurized module is designed to accommodate pressurized payloads. It has a capacity of 24 rack locations, and payload racks will occupy 13 locations especially designed to support experiments. The ISS is a multidisciplinary laboratory, technology test bed, and observatory that will provide unprecedented undertakings in scientific, technological, and international experimentation.

Long-term implications of feed energy source in different genetic types of reproductive rabbit females: I. Resource acquisition and allocation.

PubMed

Arnau-Bonachera, A; Cervera, C; Blas, E; Larsen, T; Martínez-Paredes, E; Ródenas, L; Pascual, J J

2017-12-11

To achieve functional but also productive females, we hypothesised that it is possible to modulate acquisition and allocation of animals from different genetic types by varying the main energy source of the diet. To test this hypothesis, we used 203 rabbit females belonging to three genetic types: H (n=66), a maternal line characterised by hyper-prolificacy; LP (n=67), a maternal line characterised by functional hyper-longevity; R (n=79), a paternal line characterised by growth rate. Females were fed with two isoenergetic and isoprotein diets differing in energy source: animal fat (AF) enhancing milk yield; cereal starch (CS) promoting body reserves recovery. Feed intake, weight, perirenal fat thickness (PFT), milk yield and blood traits were controlled during five consecutive reproductive cycles (RCs). Females fed with CS presented higher PFT (+0.2 mm, P0.05), particularly for those fed with AF. Moreover, LP females fed with AF progressively increased PFT across the RC, whereas those fed with CS increased PFT during early lactation (+7.3%; P<0.05), but partially mobilised it during late lactation (-2.8%; P<0.05). Independently of the diet offered, LP females reached weaning with similar PFT. H females fed with either of the two diets followed a similar trajectory throughout the RC. For milk yield, the effect of energy source was almost constant during the whole experiment, except for the first RC of females from the maternal lines (H and LP). These females yielded +34.1% (P<0.05) when fed with CS during this period. Results from this work indicate that the resource acquisition capacity and allocation pattern of rabbit females is different for each genetic type. Moreover, it seems that by varying the main energy source of the diet it is possible to modulate acquisition and allocation of resources of the different genetic types. However, the response of each one depends on its priorities over time.

Instantaneous frequency based newborn EEG seizure characterisation

NASA Astrophysics Data System (ADS)

Mesbah, Mostefa; O'Toole, John M.; Colditz, Paul B.; Boashash, Boualem

2012-12-01

The electroencephalogram (EEG), used to noninvasively monitor brain activity, remains the most reliable tool in the diagnosis of neonatal seizures. Due to their nonstationary and multi-component nature, newborn EEG seizures are better represented in the joint time-frequency domain than in either the time domain or the frequency domain. Characterising newborn EEG seizure nonstationarities helps to better understand their time-varying nature and, therefore, allow developing efficient signal processing methods for both modelling and seizure detection and classification. In this article, we used the instantaneous frequency (IF) extracted from a time-frequency distribution to characterise newborn EEG seizures. We fitted four frequency modulated (FM) models to the extracted IFs, namely a linear FM, a piecewise-linear FM, a sinusoidal FM, and a hyperbolic FM. Using a database of 30-s EEG seizure epochs acquired from 35 newborns, we were able to show that, depending on EEG channel, the sinusoidal and piecewise-linear FM models best fitted 80-98% of seizure epochs. To further characterise the EEG seizures, we calculated the mean frequency and frequency span of the extracted IFs. We showed that in the majority of the cases (>95%), the mean frequency resides in the 0.6-3 Hz band with a frequency span of 0.2-1 Hz. In terms of the frequency of occurrence of the four seizure models, the statistical analysis showed that there is no significant difference( p = 0.332) between the two hemispheres. The results also indicate that there is no significant differences between the two hemispheres in terms of the mean frequency ( p = 0.186) and the frequency span ( p = 0.302).

Complexity Measures in Magnetoencephalography: Measuring "Disorder" in Schizophrenia

PubMed Central

Brookes, Matthew J.; Hall, Emma L.; Robson, Siân E.; Price, Darren; Palaniyappan, Lena; Liddle, Elizabeth B.; Liddle, Peter F.; Robinson, Stephen E.; Morris, Peter G.

2015-01-01

This paper details a methodology which, when applied to magnetoencephalography (MEG) data, is capable of measuring the spatio-temporal dynamics of ‘disorder’ in the human brain. Our method, which is based upon signal entropy, shows that spatially separate brain regions (or networks) generate temporally independent entropy time-courses. These time-courses are modulated by cognitive tasks, with an increase in local neural processing characterised by localised and transient increases in entropy in the neural signal. We explore the relationship between entropy and the more established time-frequency decomposition methods, which elucidate the temporal evolution of neural oscillations. We observe a direct but complex relationship between entropy and oscillatory amplitude, which suggests that these metrics are complementary. Finally, we provide a demonstration of the clinical utility of our method, using it to shed light on aberrant neurophysiological processing in schizophrenia. We demonstrate significantly increased task induced entropy change in patients (compared to controls) in multiple brain regions, including a cingulo-insula network, bilateral insula cortices and a right fronto-parietal network. These findings demonstrate potential clinical utility for our method and support a recent hypothesis that schizophrenia can be characterised by abnormalities in the salience network (a well characterised distributed network comprising bilateral insula and cingulate cortices). PMID:25886553

KSC-03PD-1776

NASA Technical Reports Server (NTRS)

2003-01-01

KENNEDY SPACE CENTER, FLA. The Italian-built module, U.S. Node 2, for the International Space Station is offloaded from a Beluga at the Shuttle Landing Facility. The second of three Station connecting modules, Node 2 attaches to the end of the U.S. Lab and provides attach locations for the Japanese laboratory, European laboratory, the Centrifuge Accommodation Module and, later, Multipurpose Logistics Modules. It will provide the primary docking location for the Shuttle when a pressurized mating adapter is attached to Node 2. Installation of the module will complete the U.S. Core of the ISS. Node 2 is the designated payload for mission STS-120. No orbiter or launch date has been determined yet.

Cancer Incidence among Persons with Fragile X Syndrome in Finland: A Population-Based Study

ERIC Educational Resources Information Center

Sund, Reijo; Pukkala, E.; Patja, K.

2009-01-01

Background: Fragile X syndrome is a common inheritable cause of intellectual disability (ID) and is characterised by a large number of CGG repeats at the gene "FMR1" located on the X-chromosome. It has been reported that this genetic mechanism may protect against malignant transformations. Methods: We extracted from the Finnish registry…

Transnational Skills Development in Post-Industrial Knowledge Economies: The Case of Luxembourg and The Greater Region

ERIC Educational Resources Information Center

Graf, Lukas; Gardin, Matias

2018-01-01

Luxembourg exhibits strong transnational traits within its skills regime, defying any neat fit with existing educational typologies. It is characterised by its high-skill economy, cross-cultural characteristics, and central location within the European Union. As such, Luxembourg has developed a hybrid strategy of responding to labour market…

North, South, Least, Best: Geographical Location and the Thinking Styles of Italian University Students

ERIC Educational Resources Information Center

Sofo, Francesco; Berzins, Michelle; Colapinto, Cinzia; Ammirato, Salvatore

2009-01-01

There are economic and socio-cultural differences that characterise the north and south of Italy. A stereotype is that university students from rural southern Italy are more disadvantaged and isolated than those from the urban north. Past research has hypothesised that differences in socio-economic status impact on student learning, which is a…

A Pilot Survey of Patient-Initiated Assaults on Medical Students during Clinical Clerkship

ERIC Educational Resources Information Center

Waddell, Andrea E.; Katz, Mark R.; Lofchy, Jodi; Bradley, John

2005-01-01

Objectives: To assess the incidents of patient-initiated assault (PIA) against clinical clerks during the first six months of clinical clerkship. To characterise the assaults with respect to service, location, clerk gender, patient gender. To examine the students' perceptions of the reporting process for PIA. Methods: A brief email survey was sent…

Application of pulsed-field gel electrophoresis to characterise and trace the prevalence of Enterobacter sakazakii in an infant formula processing facility.

PubMed

Mullane, N R; Whyte, P; Wall, P G; Quinn, T; Fanning, S

2007-05-01

Enterobacter sakazakii (E. sakazakii) contamination of powdered infant formula (PIF) and its processing environment was monitored between April 2005 and March 2006. The purpose of the monitoring programme was to locate points of contamination, investigate clonal persistence, and identify possible dissemination routes along the processing chain. A total of 80 E. sakazakii isolates were recovered from the manufacturing facility. The overall frequency of isolation of E. sakazakii in intermediate and final product was 2.5%, while specific locations in the processing environment were contaminated at frequencies up to 31%. All E. sakazakii isolates were characterised by pulsed-field gel electrophoresis (PFGE). XbaI macrorestriction digests yielded 19 unique pulse-types that could be grouped into 6 clusters of between 5 and 32 isolates. The formation of large clusters was consistent with the presence of a number of clones in the manufacturing environment. While the majority of isolates were of environmental origin (72.5%), no cluster was confined to one specific location and indistinguishable PFGE profiles were generated from isolates cultured from the manufacturing environment, sampling points along the processing chain and from intermediate and final product. These findings suggest that the manufacturing environment serves as a key route for sporadic contamination of PIF. These data will support the development of efficient intervention measures contributing to the reduction of E. sakazakii in the PIF processing chain.

STS-98 Onboard Photograph-U.S. Laboratory, Destiny

NASA Technical Reports Server (NTRS)

2001-01-01

This STS-98 Shuttle mission image shows an overall interior view of the newly attached U.S. Laboratory, Destiny. The American-made Destiny module is the cornerstone for space-based research aboard the orbiting platform and the centerpiece of the International Space Station (ISS), where unprecedented science experiments will be performed in the near-zero gravity of space. Destiny will also serve as the command and control center for the ISS. The aluminum module is 8.5-meters (28-feet) long and 4.3-meters (14-feet) in diameter. The laboratory consists of three cylindrical sections and two endcones with hatches that will be mated to other station components. A 50.9-centimeter (20-inch-) diameter window is located on one side of the center module segment. This pressurized module is designed to accommodate pressurized payloads. It has a capacity of 24 rack locations. Payload racks will occupy 15 locations especially designed to support experiments. The Destiny module was built by the Boeing Company under the direction of the Marshall Space Flight Center.

International Space Station (ISS)

NASA Image and Video Library

2001-02-11

This STS-98 mission photograph shows astronauts Thomas D. Jones (foreground) and Kerneth D. Cockrell floating inside the newly installed Laboratory aboard the International Space Station (ISS). The American-made Destiny module is the cornerstone for space-based research aboard the orbiting platform and the centerpiece of the ISS, where unprecedented science experiments will be performed in the near-zero gravity of space. Destiny will also serve as the command and control center for the ISS. The aluminum module is 8.5-meters (28-feet) long and 4.3-meters (14-feet) in diameter. The laboratory consists of three cylindrical sections and two endcones with hatches that will be mated to other station components. A 50.9-centimeter (20-inch-) diameter window is located on one side of the center module segment. This pressurized module is designed to accommodate pressurized payloads. It has a capacity of 24 rack locations. Payload racks will occupy 15 locations especially designed to support experiments. The Destiny module was built by the Boeing Company under the direction of the Marshall Space Flight Center.

Identification and characterisation of isoprene-degrading bacteria in an estuarine environment.

PubMed

Johnston, Antonia; Crombie, Andrew T; El Khawand, Myriam; Sims, Leanne; Whited, Gregg M; McGenity, Terry J; Colin Murrell, J

2017-09-01

Approximately one-third of volatile organic compounds (VOCs) emitted to the atmosphere consists of isoprene, originating from the terrestrial and marine biosphere, with a profound effect on atmospheric chemistry. However, isoprene provides an abundant and largely unexplored source of carbon and energy for microbes. The potential for isoprene degradation in marine and estuarine samples from the Colne Estuary, UK, was investigated using DNA-Stable Isotope Probing (DNA-SIP). Analysis at two timepoints showed the development of communities dominated by Actinobacteria including members of the genera Mycobacterium, Rhodococcus, Microbacterium and Gordonia. Representative isolates, capable of growth on isoprene as sole carbon and energy source, were obtained from marine and estuarine locations, and isoprene-degrading strains of Gordonia and Mycobacterium were characterised physiologically and their genomes were sequenced. Genes predicted to be required for isoprene metabolism, including four-component isoprene monooxygenases (IsoMO), were identified and compared with previously characterised examples. Transcriptional and activity assays of strains growing on isoprene or alternative carbon sources showed that growth on isoprene is an inducible trait requiring a specific IsoMO. This study is the first to identify active isoprene degraders in estuarine and marine environments using DNA-SIP and to characterise marine isoprene-degrading bacteria at the physiological and molecular level. © 2017 The Authors. Environmental Microbiology published by Society for Applied Microbiology and John Wiley & Sons Ltd.

Characterising human atherosclerotic carotid plaque tissue composition and morphology using combined spectroscopic and imaging modalities.

PubMed

Barrett, Hilary E; Mulvihill, John J; Cunnane, Eoghan M; Walsh, Michael T

2015-01-01

Calcification is a marked pathological component in carotid artery plaque. Studies have suggested that calcification may induce regions of high stress concentrations therefore increasing the potential for rupture. However, the mechanical behaviour of the plaque under the influence of calcification is not fully understood. A method of accurately characterising the calcification coupled with the associated mechanical plaque properties is needed to better understand the impact of calcification on the mechanical behaviour of the plaque during minimally invasive treatments. This study proposes a comparison of biochemical and structural characterisation methods of the calcification in carotid plaque specimens to identify plaque mechanical behaviour. Biochemical analysis, by Fourier Transform Infrared (FTIR) spectroscopy, was used to identify the key components, including calcification, in each plaque sample. However, FTIR has a finite penetration depth which may limit the accuracy of the calcification measurement. Therefore, this FTIR analysis was coupled with the identification of the calcification inclusions located internally in the plaque specimen using micro x-ray computed tomography (μX-CT) which measures the calcification volume fraction (CVF) to total tissue content. The tissue characterisation processes were then applied to the mechanical material plaque properties acquired from experimental circumferential loading of human carotid plaque specimen for comparison of the methods. FTIR characterised the degree of plaque progression by identifying the functional groups associated with lipid, collagen and calcification in each specimen. This identified a negative relationship between stiffness and 'lipid to collagen' and 'calcification to collagen' ratios. However, μX-CT results suggest that CVF measurements relate to overall mechanical stiffness, while peak circumferential strength values may be dependent on specific calcification geometries. This study demonstrates the need to fully characterise the calcification structure of the plaque tissue and that a combination of FTIR and μX-CT provides the necessary information to fully understand the mechanical behaviour of the plaque tissue.

KENNEDY SPACE CENTER, FLA. - Workers in the Space Station Processing Facility look over paperwork during a Multi-Element Integrated Test (MEIT) of the U.S. Node 2 and the Japanese Experiment Module (JEM). Node 2 attaches to the end of the U.S. Lab on the ISS and provides attach locations for the Japanese laboratory, European laboratory, the Centrifuge Accommodation Module and, eventually, Multipurpose Logistics Modules. It will provide the primary docking location for the Shuttle when a pressurized mating adapter is attached to Node 2. Installation of the module will complete the U.S. Core of the ISS. The JEM, developed by the National Space Development Agency of Japan (NASDA), is Japan's primary contribution to the Station. It will enhance the unique research capabilities of the orbiting complex by providing an additional environment for astronauts to conduct science experiments.

NASA Image and Video Library

2003-09-03

KENNEDY SPACE CENTER, FLA. - Workers in the Space Station Processing Facility look over paperwork during a Multi-Element Integrated Test (MEIT) of the U.S. Node 2 and the Japanese Experiment Module (JEM). Node 2 attaches to the end of the U.S. Lab on the ISS and provides attach locations for the Japanese laboratory, European laboratory, the Centrifuge Accommodation Module and, eventually, Multipurpose Logistics Modules. It will provide the primary docking location for the Shuttle when a pressurized mating adapter is attached to Node 2. Installation of the module will complete the U.S. Core of the ISS. The JEM, developed by the National Space Development Agency of Japan (NASDA), is Japan's primary contribution to the Station. It will enhance the unique research capabilities of the orbiting complex by providing an additional environment for astronauts to conduct science experiments.

KENNEDY SPACE CENTER, FLA. - Astronaut Soichi Noguchi, with the National Space Development Agency of Japan (NASDA), works at a console during a Multi-Element Integrated Test (MEIT) of the U.S. Node 2 and the Japanese Experiment Module (JEM). Noguchi is assigned to mission STS-114 as a mission specialist. Node 2 attaches to the end of the U.S. Lab on the ISS and provides attach locations for the Japanese laboratory, European laboratory, the Centrifuge Accommodation Module and, eventually, Multipurpose Logistics Modules. It will provide the primary docking location for the Shuttle when a pressurized mating adapter is attached to Node 2. Installation of the module will complete the U.S. Core of the ISS. The JEM, developed by NASDA, is Japan's primary contribution to the Station. It will enhance the unique research capabilities of the orbiting complex by providing an additional environment for astronauts to conduct science experiments.

NASA Image and Video Library

2003-09-03

KENNEDY SPACE CENTER, FLA. - Astronaut Soichi Noguchi, with the National Space Development Agency of Japan (NASDA), works at a console during a Multi-Element Integrated Test (MEIT) of the U.S. Node 2 and the Japanese Experiment Module (JEM). Noguchi is assigned to mission STS-114 as a mission specialist. Node 2 attaches to the end of the U.S. Lab on the ISS and provides attach locations for the Japanese laboratory, European laboratory, the Centrifuge Accommodation Module and, eventually, Multipurpose Logistics Modules. It will provide the primary docking location for the Shuttle when a pressurized mating adapter is attached to Node 2. Installation of the module will complete the U.S. Core of the ISS. The JEM, developed by NASDA, is Japan's primary contribution to the Station. It will enhance the unique research capabilities of the orbiting complex by providing an additional environment for astronauts to conduct science experiments.

KENNEDY SPACE CENTER, FLA. - Astronaut Soichi Noguchi, with the National Space Development Agency of Japan (NASDA), is inside the Japanese Experiment Module (JEM), undergoing a Multi-Element Integrated Test (MEIT) in the Space Station Processing Facility. Noguchi is assigned to mission STS-114 as a mission specialist. Node 2 attaches to the end of the U.S. Lab on the ISS and provides attach locations for the Japanese laboratory, European laboratory, the Centrifuge Accommodation Module and, eventually, Multipurpose Logistics Modules. It will provide the primary docking location for the Shuttle when a pressurized mating adapter is attached to Node 2. Installation of the module will complete the U.S. Core of the ISS. The JEM, developed by NASDA, is Japan's primary contribution to the Station. It will enhance the unique research capabilities of the orbiting complex by providing an additional environment for astronauts to conduct science experiments.

NASA Image and Video Library

2003-09-03

KENNEDY SPACE CENTER, FLA. - Astronaut Soichi Noguchi, with the National Space Development Agency of Japan (NASDA), is inside the Japanese Experiment Module (JEM), undergoing a Multi-Element Integrated Test (MEIT) in the Space Station Processing Facility. Noguchi is assigned to mission STS-114 as a mission specialist. Node 2 attaches to the end of the U.S. Lab on the ISS and provides attach locations for the Japanese laboratory, European laboratory, the Centrifuge Accommodation Module and, eventually, Multipurpose Logistics Modules. It will provide the primary docking location for the Shuttle when a pressurized mating adapter is attached to Node 2. Installation of the module will complete the U.S. Core of the ISS. The JEM, developed by NASDA, is Japan's primary contribution to the Station. It will enhance the unique research capabilities of the orbiting complex by providing an additional environment for astronauts to conduct science experiments.

KENNEDY SPACE CENTER, FLA. - Astronaut Soichi Noguchi, with the National Space Development Agency of Japan (NASDA), rests inside the Japanese Experiment Module (JEM), undergoing a Multi-Element Integrated Test (MEIT) in the Space Station Processing Facility. Noguchi is assigned to mission STS-114 as a mission specialist. Node 2 attaches to the end of the U.S. Lab on the ISS and provides attach locations for the Japanese laboratory, European laboratory, the Centrifuge Accommodation Module and, eventually, Multipurpose Logistics Modules. It will provide the primary docking location for the Shuttle when a pressurized mating adapter is attached to Node 2. Installation of the module will complete the U.S. Core of the ISS. The JEM, developed by NASDA, is Japan's primary contribution to the Station. It will enhance the unique research capabilities of the orbiting complex by providing an additional environment for astronauts to conduct science experiments.

NASA Image and Video Library

2003-09-03

KENNEDY SPACE CENTER, FLA. - Astronaut Soichi Noguchi, with the National Space Development Agency of Japan (NASDA), rests inside the Japanese Experiment Module (JEM), undergoing a Multi-Element Integrated Test (MEIT) in the Space Station Processing Facility. Noguchi is assigned to mission STS-114 as a mission specialist. Node 2 attaches to the end of the U.S. Lab on the ISS and provides attach locations for the Japanese laboratory, European laboratory, the Centrifuge Accommodation Module and, eventually, Multipurpose Logistics Modules. It will provide the primary docking location for the Shuttle when a pressurized mating adapter is attached to Node 2. Installation of the module will complete the U.S. Core of the ISS. The JEM, developed by NASDA, is Japan's primary contribution to the Station. It will enhance the unique research capabilities of the orbiting complex by providing an additional environment for astronauts to conduct science experiments.

KENNEDY SPACE CENTER, FLA. - Astronaut Soichi Noguchi (right), with the National Space Development Agency of Japan (NASDA), is inside the Japanese Experiment Module (JEM), undergoing a Multi-Element Integrated Test (MEIT) in the Space Station Processing Facility. Noguchi is assigned to mission STS-114 as a mission specialist. Node 2 attaches to the end of the U.S. Lab on the ISS and provides attach locations for the Japanese laboratory, European laboratory, the Centrifuge Accommodation Module and, eventually, Multipurpose Logistics Modules. It will provide the primary docking location for the Shuttle when a pressurized mating adapter is attached to Node 2. Installation of the module will complete the U.S. Core of the ISS. The JEM, developed by NASDA, is Japan's primary contribution to the Station. It will enhance the unique research capabilities of the orbiting complex by providing an additional environment for astronauts to conduct science experiments.

NASA Image and Video Library

2003-09-03

KENNEDY SPACE CENTER, FLA. - Astronaut Soichi Noguchi (right), with the National Space Development Agency of Japan (NASDA), is inside the Japanese Experiment Module (JEM), undergoing a Multi-Element Integrated Test (MEIT) in the Space Station Processing Facility. Noguchi is assigned to mission STS-114 as a mission specialist. Node 2 attaches to the end of the U.S. Lab on the ISS and provides attach locations for the Japanese laboratory, European laboratory, the Centrifuge Accommodation Module and, eventually, Multipurpose Logistics Modules. It will provide the primary docking location for the Shuttle when a pressurized mating adapter is attached to Node 2. Installation of the module will complete the U.S. Core of the ISS. The JEM, developed by NASDA, is Japan's primary contribution to the Station. It will enhance the unique research capabilities of the orbiting complex by providing an additional environment for astronauts to conduct science experiments.

KENNEDY SPACE CENTER, FLA. - Astronaut Soichi Noguchi, with the National Space Development Agency of Japan (NASDA), signals success during a Multi-Element Integrated Test (MEIT ) of the Japanese Experiment Module (JEM) in the Space Station Processing Facility. Noguchi is assigned to mission STS-114 as a mission specialist. Node 2 attaches to the end of the U.S. Lab on the ISS and provides attach locations for the Japanese laboratory, European laboratory, the Centrifuge Accommodation Module and, eventually, Multipurpose Logistics Modules. It will provide the primary docking location for the Shuttle when a pressurized mating adapter is attached to Node 2. Installation of the module will complete the U.S. Core of the ISS. The JEM, developed by NASDA, is Japan's primary contribution to the Station. It will enhance the unique research capabilities of the orbiting complex by providing an additional environment for astronauts to conduct science experiments.

NASA Image and Video Library

2003-09-03

KENNEDY SPACE CENTER, FLA. - Astronaut Soichi Noguchi, with the National Space Development Agency of Japan (NASDA), signals success during a Multi-Element Integrated Test (MEIT ) of the Japanese Experiment Module (JEM) in the Space Station Processing Facility. Noguchi is assigned to mission STS-114 as a mission specialist. Node 2 attaches to the end of the U.S. Lab on the ISS and provides attach locations for the Japanese laboratory, European laboratory, the Centrifuge Accommodation Module and, eventually, Multipurpose Logistics Modules. It will provide the primary docking location for the Shuttle when a pressurized mating adapter is attached to Node 2. Installation of the module will complete the U.S. Core of the ISS. The JEM, developed by NASDA, is Japan's primary contribution to the Station. It will enhance the unique research capabilities of the orbiting complex by providing an additional environment for astronauts to conduct science experiments.

Probabilistic seismic hazard analysis for a nuclear power plant site in southeast Brazil

NASA Astrophysics Data System (ADS)

de Almeida, Andréia Abreu Diniz; Assumpção, Marcelo; Bommer, Julian J.; Drouet, Stéphane; Riccomini, Claudio; Prates, Carlos L. M.

2018-05-01

A site-specific probabilistic seismic hazard analysis (PSHA) has been performed for the only nuclear power plant site in Brazil, located 130 km southwest of Rio de Janeiro at Angra dos Reis. Logic trees were developed for both the seismic source characterisation and ground-motion characterisation models, in both cases seeking to capture the appreciable ranges of epistemic uncertainty with relatively few branches. This logic-tree structure allowed the hazard calculations to be performed efficiently while obtaining results that reflect the inevitable uncertainty in long-term seismic hazard assessment in this tectonically stable region. An innovative feature of the study is an additional seismic source zone added to capture the potential contributions of characteristics earthquake associated with geological faults in the region surrounding the coastal site.

Rotor component displacement measurement system

DOEpatents

Mercer, Gary D.; Li, Ming C.; Baum, Charles R.

2003-05-27

A measuring system for measuring axial displacement of a tube relative to an axially stationary component in a rotating rotor assembly includes at least one displacement sensor adapted to be located normal to a longitudinal axis of the tube; an insulated cable system adapted for passage through the rotor assembly; a rotatable proximitor module located axially beyond the rotor assembly to which the cables are connected; and a telemetry system operatively connected to the proximitor module for sampling signals from the proximitor module and forwarding data to a ground station.

Multimedia-based decision support system for hazards recognition and abatement

DOEpatents

Czachowski, John B.; Zoldak, John T.

1998-01-01

A system for monitoring a site includes a portable data collection module used in the field to collect site specific data, and a processor module located at a central location. The data collection module displays choices of categories of findings, and then specific findings within each category. A selected specific finding is then displayed in report form with a citation to the specific code or statutory requirement, as well as a recommended course of action and an abatement date.

Apollo 13 Service Module

NASA Image and Video Library

1970-04-17

AS13-59-8500A (17 April 1970) --- This view of the severely damaged Apollo 13 Service Module (SM) was photographed from the Lunar Module/Command Module (LM/CM) following SM jettisoning. As seen in this cropped image, enlarged to provide a close-up view of the damaged area, an entire panel on the SM was blown away by the apparent explosion of oxygen tank number two located in Sector 4 of the SM. Two of the three fuel cells are visible just forward (above) the heavily damaged area. Three fuel cells, two oxygen tanks, and two hydrogen tanks are located in Sector 4. The damaged area is located above the S-Band high gain antenna. Nearest the camera is the Service Propulsion System (SPS) engine and nozzle. The damage to the SM caused the Apollo 13 crew members to use the LM as a "lifeboat". The LM was jettisoned just prior to Earth re-entry by the CM. Photo credit: NASA

SPACEHAB module at LC-39B for STS-76

NASA Technical Reports Server (NTRS)

1996-01-01

At Launch Pad 39B, the SPACEHAB module has been installed in the payload bay of the Space Shuttle Atlantis, which was rolled out to the pad a day previously. Already located in the payload bay was the Orbiter Docking System (ODS), to which the SPACEHAB was connected via a tunnel. During the upcoming flight of Atlantis on Mission STS-76, the ODS will be docked to the Docking Module located on the Kristall module docking port on the Russian Space Station Mir. The SPACEHAB will be filled with Russian and U.S. logistics equipment for transfer to Mir. Also located in the mini-research laboratory is the European Space Agency's Biorack, which houses experiments to be conducted by the U.S. astronauts during the nine-day flight. Atlantis is scheduled to lift off on the third Shuttle-Mir docking mission on March 21.

Attenuation of dopamine-modulated prefrontal value signals underlies probabilistic reward learning deficits in old age

PubMed Central

Axelsson, Jan; Riklund, Katrine; Nyberg, Lars; Dayan, Peter; Bäckman, Lars

2017-01-01

Probabilistic reward learning is characterised by individual differences that become acute in aging. This may be due to age-related dopamine (DA) decline affecting neural processing in striatum, prefrontal cortex, or both. We examined this by administering a probabilistic reward learning task to younger and older adults, and combining computational modelling of behaviour, fMRI and PET measurements of DA D1 availability. We found that anticipatory value signals in ventromedial prefrontal cortex (vmPFC) were attenuated in older adults. The strength of this signal predicted performance beyond age and was modulated by D1 availability in nucleus accumbens. These results uncover that a value-anticipation mechanism in vmPFC declines in aging, and that this mechanism is associated with DA D1 receptor availability. PMID:28870286

How bees distinguish patterns by green and blue modulation

PubMed Central

Horridge, Adrian

2015-01-01

In the 1920s, Mathilde Hertz found that trained bees discriminated between shapes or patterns of similar size by something related to total length of contrasting contours. This input is now interpreted as modulation in green and blue receptor channels as flying bees scan in the horizontal plane. Modulation is defined as total contrast irrespective of sign multiplied by length of edge displaying that contrast, projected to vertical, therefore, combining structure and contrast in a single input. Contrast is outside the eye; modulation is a phasic response in receptor pathways inside. In recent experiments, bees trained to distinguish color detected, located, and measured three independent inputs and the angles between them. They are the tonic response of the blue receptor pathway and modulation of small-field green or (less preferred) blue receptor pathways. Green and blue channels interacted intimately at a peripheral level. This study explores in more detail how various patterns are discriminated by these cues. The direction of contrast at a boundary was not detected. Instead, bees located and measured total modulation generated by horizontal scanning of contrasts, irrespective of pattern. They also located the positions of isolated vertical edges relative to other landmarks and distinguished the angular widths between vertical edges by green or blue modulation alone. The preferred inputs were the strongest green modulation signal and angular width between outside edges, irrespective of color. In the absence of green modulation, the remaining cue was a measure and location of blue modulation at edges. In the presence of green modulation, blue modulation was inhibited. Black/white patterns were distinguished by the same inputs in blue and green receptor channels. Left–right polarity and mirror images could be discriminated by retinotopic green modulation alone. Colors in areas bounded by strong green contrast were distinguished as more or less blue than the background. The blue content could also be summed over the whole target. There were no achromatic patterns for bees and no evidence that they detected black, white, or gray levels apart from the differences in blue content or modulation at edges. Most of these cues would be sensitive to background color but some were influenced by changes in illumination. The bees usually learned only to avoid the unrewarded target. Exactly the same preferences of the same inputs were used in the detection of single targets as in discrimination between two targets. PMID:28539796

Abstract feature codes: The building blocks of the implicit learning system.

PubMed

Eberhardt, Katharina; Esser, Sarah; Haider, Hilde

2017-07-01

According to the Theory of Event Coding (TEC; Hommel, Müsseler, Aschersleben, & Prinz, 2001), action and perception are represented in a shared format in the cognitive system by means of feature codes. In implicit sequence learning research, it is still common to make a conceptual difference between independent motor and perceptual sequences. This supposedly independent learning takes place in encapsulated modules (Keele, Ivry, Mayr, Hazeltine, & Heuer 2003) that process information along single dimensions. These dimensions have remained underspecified so far. It is especially not clear whether stimulus and response characteristics are processed in separate modules. Here, we suggest that feature dimensions as they are described in the TEC should be viewed as the basic content of modules of implicit learning. This means that the modules process all stimulus and response information related to certain feature dimensions of the perceptual environment. In 3 experiments, we investigated by means of a serial reaction time task the nature of the basic units of implicit learning. As a test case, we used stimulus location sequence learning. The results show that a stimulus location sequence and a response location sequence cannot be learned without interference (Experiment 2) unless one of the sequences can be coded via an alternative, nonspatial dimension (Experiment 3). These results support the notion that spatial location is one module of the implicit learning system and, consequently, that there are no separate processing units for stimulus versus response locations. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

A cross-species socio-emotional behaviour development revealed by a multivariate analysis.

PubMed

Koshiba, Mamiko; Senoo, Aya; Mimura, Koki; Shirakawa, Yuka; Karino, Genta; Obara, Saya; Ozawa, Shinpei; Sekihara, Hitomi; Fukushima, Yuta; Ueda, Toyotoshi; Kishino, Hirohisa; Tanaka, Toshihisa; Ishibashi, Hidetoshi; Yamanouchi, Hideo; Yui, Kunio; Nakamura, Shun

2013-01-01

Recent progress in affective neuroscience and social neurobiology has been propelled by neuro-imaging technology and epigenetic approach in neurobiology of animal behaviour. However, quantitative measurements of socio-emotional development remains lacking, though sensory-motor development has been extensively studied in terms of digitised imaging analysis. Here, we developed a method for socio-emotional behaviour measurement that is based on the video recordings under well-defined social context using animal models with variously social sensory interaction during development. The behaviour features digitized from the video recordings were visualised in a multivariate statistic space using principal component analysis. The clustering of the behaviour parameters suggested the existence of species- and stage-specific as well as cross-species behaviour modules. These modules were used to characterise the behaviour of children with or without autism spectrum disorders (ASDs). We found that socio-emotional behaviour is highly dependent on social context and the cross-species behaviour modules may predict neurobiological basis of ASDs.

Variability of the caprine whey protein genes and their association with milk yield, composition and renneting properties in the Sarda breed. 1. The LALBA gene.

PubMed

Dettori, Maria Luisa; Pazzola, Michele; Paschino, Pietro; Pira, Maria Giovanna; Vacca, Giuseppe Massimo

2015-11-01

The 5' flanking region and 3' UTR of the caprine LALBA gene were analysed by SSCP and sequencing. A total of nine SNPs were detected: three in the promoter region, two were synonymous coding SNPs at exon-1, and four SNPs were in exon-4, within the 3'UTR. The nucleotide changes located in the promoter region (c.-358T>C, c.-163G>A, c.-121T>G) were genotyped by SSCP in 263 Sarda goats to evaluate their possible effect on milk yield, composition and renneting properties. We observed an effect of the three SNPs on milk yield and lactose content. Genotypes TT and CT at c.-358T>C (P A (P C and c.-121T>G were part of transcription factors binding sites, potentially involved in modulating the LALBA gene expression. The LALBA genotype affected renneting properties (P < 0.001), as heterozygotes c.-358CT and c.-163GA were characterised by delayed rennet coagulation time and curd firming time and the lowest value of curd firmness. The present investigation increases the panel of SNPs and adds new information about the effects of the caprine LALBA gene polymorphism.

A framework for assessment and characterisation of municipal solid waste landfill leachate: an application to the Turbhe landfill, Navi Mumbai, India.

PubMed

Mishra, Harshit; Rathod, Merwan; Karmakar, Subhankar; Kumar, Rakesh

2016-06-01

Rapid industrialisation, growing population and changing lifestyles are the root causes for the generation of huge amounts of solid waste in developing countries. In India, disposal of municipal solid waste (MSW) through open dumping is the most common waste disposal method. Unfortunately, leachate generation from landfill is high due to the prolonged and prominent monsoon season in India. As leachate generation rate is high in most of the tropical countries, long-term and extensive monitoring efforts are expected to evaluate actual environmental pollution potential due to leachate contamination. However, the leachate characterisation involves a comprehensive process, which has numerous shortcomings and uncertainties possibly due to the complex nature of landfilling process, heterogeneous waste characteristics, widely varying hydrologic conditions and selection of analytes. In order to develop a sustainable MSW management strategy for protecting the surface and ground water resources, particularly from MSW landfill leachate contamination, assessment and characterisation of leachate are necessary. Numerous studies have been conducted in the past to characterise leachate quality from various municipal landfills; unfortunately, none of these propose a framework or protocol. The present study proposes a generic framework for municipal landfill leachate assessment and characterisation. The proposed framework can be applied to design any type of landfill leachate quality monitoring programme and also to facilitate improved leachate treatment activities. A landfill site located at Turbhe, Navi Mumbai, India, which had not been investigated earlier, has been selected as a case study. The proposed framework has been demonstrated on the Turbhe landfill site which is a comparatively new and the only sanitary landfill in Navi Mumbai.

Coherent optical modulation for antenna remoting

NASA Technical Reports Server (NTRS)

Fitzmartin, D. J.; Gels, R. G.; Balboni, E. J.

1991-01-01

A coherent fiber optic link employing wideband frequency modulation (FM) of the optical carrier is used to transfer radio frequency (RF) or microwave signals. This system is used to link a remotely located antenna to a conveniently located electronics processing site. The advantages of coherent analog fiber optic systems over non-coherent intensity modulated fiber optic analog transmission systems are described. An optical FM link employing an indirect transmitter to frequency modulate the optical carrier and a microwave delay line discriminator receiver is described. Measured performance data for a video signal centered at 60 MHz is presented showing the use of wideband FM in the link.

Where is Cultural Astronomy Going?

NASA Astrophysics Data System (ADS)

Sims, Lionel

2015-05-01

Archaeoastronomy has recently been characterised as 'going round in circles', failing to integrate a rapidly expanding body of data with the interpretive models of anthropology (Ruggles 2011). This paper locates some impediments to disciplinary growth in the legacy of our recent origins, a problematical conceptual vocabulary and a narrow and derivative theoretical base. Proposals are made for an alternative future for the discipline.

WITHDRAWN: Clinical Signs, Neuroanatomical Distribution and Histopathological Characterisation of Meningoencephalitis in Wild Red Foxes (Vulpes vulpes) Associated with a Novel fox Circovirus.

PubMed

Stoll, A L; Mitchell, J A; Priestnall, S L

2016-07-05

This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. Copyright © 2016 Elsevier Ltd. All rights reserved.

L' upwelling de la côte atlantique du Maroc entre 1994 et 1998

NASA Astrophysics Data System (ADS)

Makaoui, Ahmed; Orbi, Abdelattif; Hilmi, Karim; Zizah, Soukaina; Larissi, Jamila; Talbi, Mohammed

2005-12-01

The pelagic ecosystem of the Moroccan Atlantic coast is influenced by the spatiotemporal variability of upwelling. The changes in the physicochemical and biological parameters as well as their interrelationship and regrouping by the principal components analysis allowed us to subdivide the Atlantic coast in four active areas: two areas located at the north of Cape Juby (28°N), characterised by a summery activity and two areas located at the south, active permanently, with a variable intensity. To cite this article: A. Makaoui et al., C. R. Geoscience 337 (2005).

Generalised Extreme Value Distributions Provide a Natural Hypothesis for the Shape of Seed Mass Distributions

PubMed Central

2015-01-01

Among co-occurring species, values for functionally important plant traits span orders of magnitude, are uni-modal, and generally positively skewed. Such data are usually log-transformed “for normality” but no convincing mechanistic explanation for a log-normal expectation exists. Here we propose a hypothesis for the distribution of seed masses based on generalised extreme value distributions (GEVs), a class of probability distributions used in climatology to characterise the impact of event magnitudes and frequencies; events that impose strong directional selection on biological traits. In tests involving datasets from 34 locations across the globe, GEVs described log10 seed mass distributions as well or better than conventional normalising statistics in 79% of cases, and revealed a systematic tendency for an overabundance of small seed sizes associated with low latitudes. GEVs characterise disturbance events experienced in a location to which individual species’ life histories could respond, providing a natural, biological explanation for trait expression that is lacking from all previous hypotheses attempting to describe trait distributions in multispecies assemblages. We suggest that GEVs could provide a mechanistic explanation for plant trait distributions and potentially link biology and climatology under a single paradigm. PMID:25830773

SU-F-J-205: Effect of Cone Beam Factor On Cone Beam CT Number Accuracy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yao, W; Hua, C; Farr, J

Purpose: To examine the suitability of a Catphan™ 700 phantom for image quality QA of a cone beam computed tomography (CBCT) system deployed for proton therapy. Methods: Catphan phantoms, particularly Catphan™ 504, are commonly used in image quality QA for CBCT. As a newer product, Catphan™ 700 offers more tissue equivalent inserts which may be useful for generating the electron density – CT number curve for CBCT based treatment planning. The sensitometry-and-geometry module used in Catphan™ 700 is located at the end of the phantom and after the resolution line pair module. In Catphan™ 504 the line pair module ismore » located at the end of the phantom and after the sensitometry-and-geometry module. To investigate the effect of difference in location on CT number accuracy due to the cone beam factor, we scanned the Catphan™ 700 with the central plane of CBCT at the center of the phantom, line pair and sensitometry-andgeometry modules of the phantom, respectively. The protocol head and thorax scan modes were used. For each position, scans were repeated 4 times. Results: For the head scan mode, the standard deviation (SD) of the CT numbers of each insert under 4 repeated scans was up to 20 HU, 11 HU, and 11 HU, respectively, for the central plane of CBCT located at the center of the phantom, line pair, and sensitometry-and-geometry modules of the phantom. The mean of the SD was 9.9 HU, 5.7 HU, and 5.9 HU, respectively. For the thorax mode, the mean of the SD was 4.5 HU, 4.4 HU, and 4.4 HU, respectively. The assessment of image quality based on resolution and spatial linearity was not affected by imaging location changes. Conclusion: When the Catphan™ 700 was aligned to the center of imaging region, the CT number accuracy test may not meet expectations. We recommend reconfiguration of the modules.« less

Value-Driven Attentional Capture is Modulated by Spatial Context

PubMed Central

Anderson, Brian A.

2014-01-01

When stimuli are associated with reward outcome, their visual features acquire high attentional priority such that stimuli possessing those features involuntarily capture attention. Whether a particular feature is predictive of reward, however, will vary with a number of contextual factors. One such factor is spatial location: for example, red berries are likely to be found in low-lying bushes, whereas yellow bananas are likely to be found on treetops. In the present study, I explore whether the attentional priority afforded to reward-associated features is modulated by such location-based contingencies. The results demonstrate that when a stimulus feature is associated with a reward outcome in one spatial location but not another, attentional capture by that feature is selective to when it appears in the rewarded location. This finding provides insight into how reward learning effectively modulates attention in an environment with complex stimulus–reward contingencies, thereby supporting efficient foraging. PMID:26069450

Locating Health Resources. Teenage Health Teaching Modules.

ERIC Educational Resources Information Center

Education Development Center, Inc., Newton, MA.

The Teenage Health Teaching Modules (THTM) program is a health education curriculum for adolescents. Each THTM module frames an adolescent health task emphasizing development of self-assessment, communication, decision making, health advocacy, and self-management. This module offers information on how young people may avail themselves of community…

KENNEDY SPACE CENTER, FLA. - In the Space Station Processing Facility can be seen the U.S. Node 2 (at left) and the Japanese Experiment Module (JEM)’s Pressurized Module (at right). The Italian-built Node 2, the second of three Space Station connecting modules, attaches to the end of the U.S. Lab and will provide attach locations for the Japanese laboratory, European laboratory, the Centrifuge Accommodation Module and, later, Multipurpose Logistics Modules. It will provide the primary docking location for the Shuttle when a pressurized mating adapter is attached to Node 2. Installation of the module will complete the U.S. Core of the ISS. Node 2 is the designated payload for mission STS-120. No orbiter or launch date has been determined yet. The Pressurized Module is the first element of the JEM to be delivered to KSC. The JEM is Japan's primary contribution to the Station. It will enhance the unique research capabilities of the orbiting complex by providing an additional environment for astronauts to conduct science experiments. The JEM also includes an exposed facility (platform) for space environment experiments, a robotic manipulator system, and two logistics modules. The various JEM components will be assembled in space over the course of three Shuttle missions.

NASA Image and Video Library

2003-08-12

KENNEDY SPACE CENTER, FLA. - In the Space Station Processing Facility can be seen the U.S. Node 2 (at left) and the Japanese Experiment Module (JEM)’s Pressurized Module (at right). The Italian-built Node 2, the second of three Space Station connecting modules, attaches to the end of the U.S. Lab and will provide attach locations for the Japanese laboratory, European laboratory, the Centrifuge Accommodation Module and, later, Multipurpose Logistics Modules. It will provide the primary docking location for the Shuttle when a pressurized mating adapter is attached to Node 2. Installation of the module will complete the U.S. Core of the ISS. Node 2 is the designated payload for mission STS-120. No orbiter or launch date has been determined yet. The Pressurized Module is the first element of the JEM to be delivered to KSC. The JEM is Japan's primary contribution to the Station. It will enhance the unique research capabilities of the orbiting complex by providing an additional environment for astronauts to conduct science experiments. The JEM also includes an exposed facility (platform) for space environment experiments, a robotic manipulator system, and two logistics modules. The various JEM components will be assembled in space over the course of three Shuttle missions.

STS-98 Onboard Photograph-U.S. Laboratory, Destiny

NASA Technical Reports Server (NTRS)

2001-01-01

This STS-98 mission photograph shows astronauts Thomas D. Jones (foreground) and Kerneth D. Cockrell floating inside the newly installed Laboratory aboard the International Space Station (ISS). The American-made Destiny module is the cornerstone for space-based research aboard the orbiting platform and the centerpiece of the ISS, where unprecedented science experiments will be performed in the near-zero gravity of space. Destiny will also serve as the command and control center for the ISS. The aluminum module is 8.5-meters (28-feet) long and 4.3-meters (14-feet) in diameter. The laboratory consists of three cylindrical sections and two endcones with hatches that will be mated to other station components. A 50.9-centimeter (20-inch-) diameter window is located on one side of the center module segment. This pressurized module is designed to accommodate pressurized payloads. It has a capacity of 24 rack locations. Payload racks will occupy 15 locations especially designed to support experiments. The Destiny module was built by the Boeing Company under the direction of the Marshall Space Flight Center.

STS-98 Onboard Photograph-U.S. Laboratory, Destiny

NASA Technical Reports Server (NTRS)

2001-01-01

This closer image of the International Space Station (ISS) showing the newly installed U.S. Laboratory, Destiny (left), was taken from the departing Space Shuttle Atlantis. The American-made Destiny module is the cornerstone for space-based research aboard the orbiting platform and the centerpiece of the ISS, where unprecedented science experiments will be performed in the near-zero gravity of space. Destiny will also serve as the command and control center for the ISS. The aluminum module is 8.5-meters (28-feet) long and 4.3-meters (14-feet) in diameter. The laboratory consists of three cylindrical sections and two endcones with hatches that will be mated to other station components. A 50.9-centimeter (20-inch-) diameter window is located on one side of the center module segment. This pressurized module is designed to accommodate pressurized payloads. It has a capacity of 24 rack locations. Payload racks will occupy 15 locations especially designed to support experiments. The Destiny module was built by the Boeing Company under the direction of the Marshall Space Flight Center.

Modulation of spatial Stroop by object-based attention but not by space-based attention.

PubMed

Luo, Chunming; Lupiáñez, Juan; Funes, María Jesús; Fu, Xiaolan

2010-03-01

Earlier studies have shown that the spatial Stroop effect systematically decreases when a peripheral precue is presented at the same location as the target, compared to an uncued location condition. In this study, two experiments were conducted to explore whether the cueing modulation of spatial Stroop is object based and/or space based. In Experiment 1, we found evidence favouring the view that the cueing modulation of the spatial Stroop effect is entirely object based, as no differences were found in conflict reduction for the same-location and same-object conditions. In Experiment 2, the cue was predictive, and a similar object-based modulation of spatial Stroop was still observed. However, the direction of such modulation was affected by the rectangles' orientation. Overall, the pattern of results obtained favours the object-integration (Lupiáñez & Milliken, 1999; Lupiáñez, Milliken, Solano, Weaver, & Tipper, 2001) and referential-coding accounts (Danziger, Kingstone, & Ward, 2001) and seems to provide evidence against the attention-shift account (Rubichi, Nicoletti, Iani, & Umilta, 1997; Stoffer, 1991).

Characterisation of the properties of a negative hydrogen ion beam by several beam diagnostic techniques

NASA Astrophysics Data System (ADS)

Maurizio, R.; Fantz, U.; Bonomo, F.; Serianni, G.

2016-06-01

The beam properties of the BATMAN negative ion source, which is the prototype of one module of the source for the ITER neutral beam injection system, are characterised by means of three diagnostic techniques: beam emission spectroscopy (BES), the experimental calorimeter mini-STRIKE and a copper calorimeter. The main beam parameters—beam divergence, homogeneity and top-bottom asymmetries—are studied in different operational scenarios: with different magnetic filter field setups, source settings and with different gases (hydrogen or deuterium). Among all dependences, the influence of the magnetic field configuration on the beam and the evolution of the beam features during some conditioning days are investigated in detail. Data show that the stronger the filter field in the beam region, the higher the beam top-bottom asymmetry—likely a v× B effect. During the conditioning of the source, such vertical beam asymmetry increases as well, suggesting an inhomogeneous H -production at the first grid of the extraction system.

Hibiscus sabdariffa L. - a phytochemical and pharmacological review.

PubMed

Da-Costa-Rocha, Inês; Bonnlaender, Bernd; Sievers, Hartwig; Pischel, Ivo; Heinrich, Michael

2014-12-15

Hibiscus sabdariffa L. (Hs, roselle; Malvaceae) has been used traditionally as a food, in herbal drinks, in hot and cold beverages, as a flavouring agent in the food industry and as a herbal medicine. In vitro and in vivo studies as well as some clinical trials provide some evidence mostly for phytochemically poorly characterised Hs extracts. Extracts showed antibacterial, anti-oxidant, nephro- and hepato-protective, renal/diuretic effect, effects on lipid metabolism (anti-cholesterol), anti-diabetic and anti-hypertensive effects among others. This might be linked to strong antioxidant activities, inhibition of α-glucosidase and α-amylase, inhibition of angiotensin-converting enzymes (ACE), and direct vaso-relaxant effect or calcium channel modulation. Phenolic acids (esp. protocatechuic acid), organic acid (hydroxycitric acid and hibiscus acid) and anthocyanins (delphinidin-3-sambubioside and cyanidin-3-sambubioside) are likely to contribute to the reported effects. More well designed controlled clinical trials are needed which use phytochemically characterised preparations. Hs has an excellent safety and tolerability record. Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.

Isolation and characterisation of mesenchymal stem/stromal cells in the ovine endometrium.

PubMed

Letouzey, Vincent; Tan, Ker Sin; Deane, James A; Ulrich, Daniela; Gurung, Shanti; Ong, Y Rue; Gargett, Caroline E

2015-01-01

Mesenchymal stem/stromal cells (MSC) were recently discovered in the human endometrium. These cells possess key stem cell properties and show promising results in small animal models when used for preclinical tissue engineering studies. A small number of surface markers have been identified that enrich for MSC from bone marrow and human endometrium, including the Sushi Domain-containing 2 (SUSD2; W5C5) and CD271 markers. In preparation for developing a large animal preclinical model for urological and gynecological tissue engineering applications we aimed to identify and characterise MSC in ovine endometrium and determine surface markers to enable their prospective isolation. Ovine endometrium was obtained from hysterectomised ewes following progesterone synchronisation, dissociated into single cell suspensions and tested for MSC surface markers and key stem cell properties. Purified stromal cells were obtained by flow cytometry sorting with CD49f and CD45 to remove epithelial cells and leukocytes respectively, and MSC properties investigated. There was a small population CD271+ stromal cells (4.5 ± 2.3%) in the ovine endometrium. Double labelling with CD271 and CD49f showed that the sorted CD271+CD49f- stromal cell population possessed significantly higher cloning efficiency, serial cloning capacity and a qualitative increased ability to differentiate into 4 mesodermal lineages (adipocytic, smooth muscle, chondrocytic and osteoblastic) than CD271-CD49f- cells. Immunolabelling studies identified an adventitial perivascular location for ovine endometrial CD271+ cells. This is the first study to characterise MSC in the ovine endometrium and identify a surface marker profile identifying their location and enabling their prospective isolation. This knowledge will allow future preclinical studies with a large animal model that is well established for pelvic organ prolapse research.

Geophysical and hydrogeological characterisation of the impacts of on-site wastewater treatment discharge to groundwater in a poorly productive bedrock aquifer.

PubMed

Donohue, Shane; McCarthy, Valerie; Rafferty, Patrick; Orr, Alison; Flynn, Raymond

2015-08-01

Contaminants discharging from on-site wastewater treatment systems (OSWTSs) can impact groundwater quality, threatening human health and surface water ecosystems. Risk of negative impacts becomes elevated in areas of extreme vulnerability with high water tables, where thin unsaturated intervals limit vadose zone attenuation. A combined geophysical/hydrogeological investigation into the effects of an OSWTS, located over a poorly productive aquifer (PPA) with thin subsoil cover, aimed to characterise effluent impacts on groundwater. Groundwater, sampled from piezometers down-gradient of the OSWTS percolation area displayed spatially erratic, yet temporally consistent, contaminant distributions. Electrical resistivity tomography identified an area of gross groundwater contamination close to the percolation area and, when combined with seismic refraction and water quality data, indicated that infiltrating effluent reaching the water table discharged to a deeper more permeable zone of weathered shale resting on more competent bedrock. Subsurface structure, defined by geophysics, indicated that elevated chemical and microbiological contaminant levels encountered in groundwater samples collected from piezometers, down-gradient of sampling points with lower contaminant levels, corresponded to those locations where piezometers were screened close to the weathered shale/competent rock interface; those immediately up-gradient were too shallow to intercept this interval, and thus the more impacted zone of the contaminant plume. Intermittent occurrence of faecal indicator bacteria more than 100m down gradient of the percolation area suggested relatively short travel times. Study findings highlight the utility of geophysics as part of multidisciplinary investigations for OSWTS contaminant plume characterisation, while also demonstrating the capacity of effluent discharging to PPAs to impact groundwater quality at distance. Comparable geophysical responses observed in similar settings across Ireland suggest the phenomena observed in this study are more widespread than previously suspected. Copyright © 2015 Elsevier B.V. All rights reserved.

Intra-operative characterisation of subthalamic oscillations in Parkinson’s disease

PubMed Central

Geng, Xinyi; Xu, Xin; Horn, Andreas; Li, Ningfei; Ling, Zhipei; Brown, Peter; Wang, Shouyan

2018-01-01

Objective This study aims to use the activities recorded directly from the deep brain stimulation (DBS) electrode to address the focality and distinct nature of the local field potential (LFP) activities of different frequency. Methods Pre-operative and intra-operative magnetic resonance imaging (MRI) were acquired from patients with Parkinson’s disease (PD) who underwent DBS in the subthalamic nucleus and intra-operative LFP recording at rest and during cued movements. Images were reconstructed and 3-D visualized using Lead-DBS® toolbox to determine the coordinates of contact. The resting spectral power and movement-related power modulation of LFP oscillations were estimated. Results Both subthalamic LFP activity recorded at rest and its modulation by movement had focal maxima in the alpha, beta and gamma bands. The spatial distribution of alpha band activity and its modulation was significantly different to that in the beta band. Moreover, there were significant differences in the scale and timing of movement related modulation across the frequency bands. Conclusion Subthalamic LFP activities within specific frequency bands can be distinguished by spatial topography and pattern of movement related modulation. Significance Assessment of the frequency, focality and pattern of movement related modulation of subthalamic LFPs reveals a heterogeneity of neural population activity in this region. This could potentially be leveraged to finesse intra-operative targeting and post-operative contact selection. PMID:29567582

The International Society for Extracellular Vesicles launches the first massive open online course on extracellular vesicles

PubMed Central

Lässer, Cecilia; Théry, Clotilde; Buzás, Edit I.; Mathivanan, Suresh; Zhao, Weian; Gho, Yong Song; Lötvall, Jan

2016-01-01

The International Society for Extracellular Vesicles (ISEV) has organised its first educational online course for students and beginners in the field of extracellular vesicles (EVs). This course, “Basics of Extracellular Vesicles,” uses recorded lectures from experts in the field and will be open for an unlimited number of participants. The course is divided into 5 modules and can be accessed at www.coursera.org/learn/extracellular-vesicles. The first module is an introduction to the field covering the nomenclature and history of EVs. Module 2 focuses on the biogenesis and uptake mechanisms of EVs, as well as their RNA, protein and lipid cargo. Module 3 covers the collection and processing of cell culture media and body fluids such as blood, breast milk, cerebrospinal fluid and urine prior to isolation of EVs. Modules 4 and 5 present different isolation methods and characterisation techniques utilised in the EV field. Here, differential ultracentrifugation, size-exclusion chromatography, density gradient centrifugation, kit-based precipitation, electron microscopy, cryo-electron microscopy, flow cytometry, atomic-force microscopy and nanoparticle-tracking analysis are covered. This first massive open online course (MOOC) on EVs was launched on 15 August 2016 at the platform “Coursera” and is free of charge. PMID:27989272

Impact of infrasound on the human cochlea.

PubMed

Hensel, Johannes; Scholz, Günther; Hurttig, Ulrike; Mrowinski, Dieter; Janssen, Thomas

2007-11-01

Low-frequency tones were reported to modulate the amplitude of distortion product otoacoustic emissions (DPOAEs) indicating periodic changes of the operating point of the cochlear amplifier. The present study investigates potential differences between infrasound and low-frequency sounds in their ability to modulate human DPOAEs. DPOAEs were recorded in 12 normally hearing subjects in the presence of a biasing tone with f(B)=6Hz and a level L(B)=130dB SPL. Primary frequencies were fixed at f(1)=1.6 and f(2)=2.0kHz with fixed levels L(1)=51 and L(2)=30dB SPL. A new measure, the modulation index (MI), was devised to characterise the degree of DPOAE modulation. In subsequent measurements with biasing tones of f(B) = 12, 24 and 50Hz, L(B) was adjusted to maintain the MI as obtained individually at 6Hz. Modulation patterns lagged with increasing f(B). The necessary L(B) decreased by 12dB/octave with increasing f(B) and ran almost parallel to the published infrasound detection threshold. No signs of an abrupt change in transmission into the cochlea were found between infra- and low-frequency sounds. The results show clearly that infrasound enters the inner ear, and can alter cochlear processing.

HYPE: a WFD tool for the identification of significant and sustained upward trends in groundwater time series

NASA Astrophysics Data System (ADS)

Lopez, Benjamin; Croiset, Nolwenn; Laurence, Gourcy

2014-05-01

The Water Framework Directive 2006/11/CE (WFD) on the protection of groundwater against pollution and deterioration asks Member States to identify significant and sustained upward trends in all bodies or groups of bodies of groundwater that are characterised as being at risk in accordance with Annex II to Directive 2000/60/EC. The Directive indicates that the procedure for the identification of significant and sustained upward trends must be based on a statistical method. Moreover, for significant increases of concentrations of pollutants, trend reversals are identified as being necessary. This means to be able to identify significant trend reversals. A specific tool, named HYPE, has been developed in order to help stakeholders working on groundwater trend assessment. The R encoded tool HYPE provides statistical analysis of groundwater time series. It follows several studies on the relevancy of the use of statistical tests on groundwater data series (Lopez et al., 2011) and other case studies on the thematic (Bourgine et al., 2012). It integrates the most powerful and robust statistical tests for hydrogeological applications. HYPE is linked to the French national database on groundwater data (ADES). So monitoring data gathered by the Water Agencies can be directly processed. HYPE has two main modules: - a characterisation module, which allows to visualize time series. HYPE calculates the main statistical characteristics and provides graphical representations; - a trend module, which identifies significant breaks, trends and trend reversals in time series, providing result table and graphical representation (cf figure). Additional modules are also implemented to identify regional and seasonal trends and to sample time series in a relevant way. HYPE has been used successfully in 2012 by the French Water Agencies to satisfy requirements of the WFD, concerning characterization of groundwater bodies' qualitative status and evaluation of the risk of non-achievement of good status. Bourgine B. et al. 2012, Ninth International Geostatistics Congress, Oslo, Norway June 11 - 15. Lopez B. et al. 2011, Final Report BRGM/RP-59515-FR. 166p.

33 CFR 149.641 - What are the structural fire protection requirements for accommodation spaces and modules?

Code of Federal Regulations, 2011 CFR

2011-07-01

... protection requirements for accommodation spaces and modules? 149.641 Section 149.641 Navigation and... the structural fire protection requirements for accommodation spaces and modules? (a) Accommodation spaces and modules must be designed, located, and constructed so as to minimize the effects of flame...

KENNEDY SPACE CENTER, FLA. - STS-120 Mission Specialists Piers Sellers and Michael Foreman are in the Space Station Processing Facility for hardware familiarization. The mission will deliver the second of three Station connecting modules, Node 2, which attaches to the end of U.S. Lab. It will provide attach locations for the Japanese laboratory, European laboratory, the Centrifuge Accommodation Module and later Multi-Purpose Logistics Modules. The addition of Node 2 will complete the U.S. core of the International Space Station.

NASA Image and Video Library

2003-07-18

KENNEDY SPACE CENTER, FLA. - STS-120 Mission Specialists Piers Sellers and Michael Foreman are in the Space Station Processing Facility for hardware familiarization. The mission will deliver the second of three Station connecting modules, Node 2, which attaches to the end of U.S. Lab. It will provide attach locations for the Japanese laboratory, European laboratory, the Centrifuge Accommodation Module and later Multi-Purpose Logistics Modules. The addition of Node 2 will complete the U.S. core of the International Space Station.

Goal-driven modulation of stimulus-driven attentional capture in multiple-cue displays.

PubMed

Richard, Christian M; Wright, Richard D; Ward, Lawrence M

2003-08-01

Six location-cuing experiments were conducted to examine the goal-driven control of attentional capture in multiple-cue displays. In most of the experiments, the cue display consisted of the simultaneous presentation of a red direct cue that was highly predictive of the target location (the unique cue) and three gray direct cues (the standard cues) that were not predictive of the location. The results indicated that although target responses were faster at all cued locations relative to uncued locations, they were significantly faster at the unique-cue location than at the standard-cue locations. Other results suggest that the faster responses produced by direct cues may be associated with two different components: an attention-related component that can be modulated by goal-driven factors and a nonattentional component that occurs in parallel at multiple direct-cue locations and is minimally affected by the same goal-driven factors.

Does rTMS Alter Neurocognitive Functioning in Patients with Panic Disorder/Agoraphobia? An fNIRS-Based Investigation of Prefrontal Activation during a Cognitive Task and Its Modulation via Sham-Controlled rTMS

PubMed Central

Sickinger, Stephanie; Haeussinger, Florian B.; Laeger, Inga; Arolt, Volker; Zwanzger, Peter; Fallgatter, Andreas J.

2014-01-01

Objectives. Neurobiologically, panic disorder (PD) is supposed to be characterised by cerebral hypofrontality. Via functional near-infrared spectroscopy (fNIRS), we investigated whether prefrontal hypoactivity during cognitive tasks in PD-patients compared to healthy controls (HC) could be replicated. As intermittent theta burst stimulation (iTBS) modulates cortical activity, we furthermore investigated its ability to normalise prefrontal activation. Methods. Forty-four PD-patients, randomised to sham or verum group, received 15 iTBS-sessions above the left dorsolateral prefrontal cortex (DLPFC) in addition to psychoeducation. Before first and after last iTBS-treatment, cortical activity during a verbal fluency task was assessed via fNIRS and compared to the results of 23 HC. Results. At baseline, PD-patients showed hypofrontality including the DLPFC, which differed significantly from activation patterns of HC. However, verum iTBS did not augment prefrontal fNIRS activation. Solely after sham iTBS, a significant increase of measured fNIRS activation in the left inferior frontal gyrus (IFG) during the phonological task was found. Conclusion. Our results support findings that PD is characterised by prefrontal hypoactivation during cognitive performance. However, verum iTBS as an “add-on” to psychoeducation did not augment prefrontal activity. Instead we only found increased fNIRS activation in the left IFG after sham iTBS application. Possible reasons including task-related psychophysiological arousal are discussed. PMID:24757668

Does rTMS alter neurocognitive functioning in patients with panic disorder/agoraphobia? An fNIRS-based investigation of prefrontal activation during a cognitive task and its modulation via sham-controlled rTMS.

PubMed

Deppermann, Saskia; Vennewald, Nadja; Diemer, Julia; Sickinger, Stephanie; Haeussinger, Florian B; Notzon, Swantje; Laeger, Inga; Arolt, Volker; Ehlis, Ann-Christine; Zwanzger, Peter; Fallgatter, Andreas J

2014-01-01

Neurobiologically, panic disorder (PD) is supposed to be characterised by cerebral hypofrontality. Via functional near-infrared spectroscopy (fNIRS), we investigated whether prefrontal hypoactivity during cognitive tasks in PD-patients compared to healthy controls (HC) could be replicated. As intermittent theta burst stimulation (iTBS) modulates cortical activity, we furthermore investigated its ability to normalise prefrontal activation. Forty-four PD-patients, randomised to sham or verum group, received 15 iTBS-sessions above the left dorsolateral prefrontal cortex (DLPFC) in addition to psychoeducation. Before first and after last iTBS-treatment, cortical activity during a verbal fluency task was assessed via fNIRS and compared to the results of 23 HC. At baseline, PD-patients showed hypofrontality including the DLPFC, which differed significantly from activation patterns of HC. However, verum iTBS did not augment prefrontal fNIRS activation. Solely after sham iTBS, a significant increase of measured fNIRS activation in the left inferior frontal gyrus (IFG) during the phonological task was found. Our results support findings that PD is characterised by prefrontal hypoactivation during cognitive performance. However, verum iTBS as an "add-on" to psychoeducation did not augment prefrontal activity. Instead we only found increased fNIRS activation in the left IFG after sham iTBS application. Possible reasons including task-related psychophysiological arousal are discussed.

The influence of habitat structure on energy allocation tactics in an estuarine batch spawner

NASA Astrophysics Data System (ADS)

Brigolin, D.; Cavraro, F.; Zanatta, V.; Pastres, R.; Malavasi, S.

2016-04-01

Trade-off between fecundity and survival was tested in a batch spawner, the Mediterranean killifish Aphanius fasciatus, using an integrated modelling-data approach based on previously collected empirical data. Two sites of the lagoon of Venice (Northern Adriatic sea, Italy) were selected in order to compare the energy allocation between growth and reproduction in two contrasting habitats. These were characterised by high and comparable level of richness in basal resources, but showed two different mortality schedules: an open natural salt marsh, exposed to high level of predation, and a confined artificial site protected from piscivorous predation. By means of a bioenergetic Scope for Growth model, developed and calibrated for the specific goals of this work, we compared the average individual life history between the two habitats. The average individual life history is characterised by a higher number of spawning events and lower per-spawning investment in the confined site exposed to lower predation risk, compared to the site connected with the open lagoon. Thus, model predictions suggest that habitat structure with different extrinsic mortality schedules may shape the life history strategy in modulating the pattern of energy allocation. Model application highlights the central role of energy partitioning through batch spawning, in determining the life history strategy. The particular ovary structure of a batch spawner seems therefore to allow the fish to modulate timing and investment of spawning events, shaping the optimal life history in relation to the environmental conditions.

Atypical right hemisphere response to slow temporal modulations in children with developmental dyslexia.

PubMed

Cutini, Simone; Szűcs, Dénes; Mead, Natasha; Huss, Martina; Goswami, Usha

2016-12-01

Phase entrainment of neuronal oscillations is thought to play a central role in encoding speech. Children with developmental dyslexia show impaired phonological processing of speech, proposed theoretically to be related to atypical phase entrainment to slower temporal modulations in speech (<10Hz). While studies of children with dyslexia have found atypical phase entrainment in the delta band (~2Hz), some studies of adults with developmental dyslexia have shown impaired entrainment in the low gamma band (~35-50Hz). Meanwhile, studies of neurotypical adults suggest asymmetric temporal sensitivity in auditory cortex, with preferential processing of slower modulations by right auditory cortex, and faster modulations processed bilaterally. Here we compared neural entrainment to slow (2Hz) versus faster (40Hz) amplitude-modulated noise using fNIRS to study possible hemispheric asymmetry effects in children with developmental dyslexia. We predicted atypical right hemisphere responding to 2Hz modulations for the children with dyslexia in comparison to control children, but equivalent responding to 40Hz modulations in both hemispheres. Analyses of HbO concentration revealed a right-lateralised region focused on the supra-marginal gyrus that was more active in children with dyslexia than in control children for 2Hz stimulation. We discuss possible links to linguistic prosodic processing, and interpret the data with respect to a neural 'temporal sampling' framework for conceptualizing the phonological deficits that characterise children with developmental dyslexia across languages. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

Reward modulation of contextual cueing: Repeated context overshadows repeated target location.

PubMed

Sharifian, Fariba; Contier, Oliver; Preuschhof, Claudia; Pollmann, Stefan

2017-10-01

Contextual cueing can be enhanced by reward. However, there is a debate if reward is associated with the repeated target-distractor configurations or with the repeated target locations that occur in both repeated and new displays. Based on neuroimaging evidence, we hypothesized that reward becomes associated with the target location only in new displays, but not in repeated displays, where the repeated target location is overshadowed by the more salient repeated target-distractor configuration. To test this hypothesis, we varied the reward value associated with the same target location in repeated and new displays. The results confirmed the overshadowing hypothesis in that search facilitation in repeated target-distractor configurations was modulated by the variable value associated with the target location. This effect was observed mainly in early learning.

Conceptualisations of infinity by primary pre-service teachers

NASA Astrophysics Data System (ADS)

Date-Huxtable, Elizabeth; Cavanagh, Michael; Coady, Carmel; Easey, Michael

2018-05-01

As part of the Opening Real Science: Authentic Mathematics and Science Education for Australia project, an online mathematics learning module embedding conceptual thinking about infinity in science-based contexts, was designed and trialled with a cohort of 22 pre-service teachers during 1 week of intensive study. This research addressed the question: "How do pre-service teachers conceptualise infinity mathematically?" Participants argued the existence of infinity in a summative reflective task, using mathematical and empirical arguments that were coded according to five themes: definition, examples, application, philosophy and teaching; and 17 codes. Participants' reflections were differentiated as to whether infinity was referred to as an abstract (A) or a real (R) concept or whether both (B) codes were used. Principal component analysis of the reflections, using frequency of codings, revealed that A and R codes occurred at different frequencies in three groups of reflections. Distinct methods of argument were associated with each group of reflections: mathematical numerical examples and empirical measurement comparisons characterised arguments for infinity as an abstract concept, geometric and empirical dynamic examples and belief statements characterised arguments for infinity as a real concept and empirical measurement and mathematical examples and belief statements characterised arguments for infinity as both an abstract and a real concept. An implication of the results is that connections between mathematical and empirical applications of infinity may assist pre-service teachers to contrast finite with infinite models of the world.

First amplification of Eimeria hessei DNA from the lesser horseshoe bat (Rhinolophus hipposideros) and its phylogenetic relationships with Eimeria species from other bats and rodents.

PubMed

Afonso, Eve; Baurand, Pierre-Emmanuel; Tournant, Pierline; Capelli, Nicolas

2014-04-01

Although coccidian parasites of the genus Eimeria are among the best-documented parasites in bats, few Eimeria species found in bats have been characterised using molecular tools, and none of the characterised species are found in European countries. Phylogenetic relationships of Eimeria species that parasitise bats and rodents can be related to the morphology of oocysts, independently from host range, suggesting that these species are derived from common ancestors. In the present study, we isolated a partial sequence of the Eimeria hessei 18S rRNA gene from the lesser horseshoe bat (Rhinolophus hipposideros), a European bat species. Droppings from lesser horseshoe bats were collected from 11 maternity roosts located in France that were positive for the presence of the parasite. Through morphological characterisation, the oocysts detected in the lesser horseshoe bat droppings were confirmed to be E. hessei. The unique E. hessei sequence obtained through molecular analysis belonged to a clade that includes both rodent and bat Eimeria species. However, the E. hessei oocysts isolated from the bat droppings did not show morphological similarities to rodent Eimeria species. Copyright © 2014 Elsevier Inc. All rights reserved.

Action preparation modulates sensory perception in unseen personal space: An electrophysiological investigation.

PubMed

Job, Xavier E; de Fockert, Jan W; van Velzen, José

2016-08-01

Behavioural and electrophysiological evidence has demonstrated that preparation of goal-directed actions modulates sensory perception at the goal location before the action is executed. However, previous studies have focused on sensory perception in areas of peripersonal space. The present study investigated visual and tactile sensory processing at the goal location of upcoming movements towards the body, much of which is not visible, as well as visible peripersonal space. A motor task cued participants to prepare a reaching movement towards goals either in peripersonal space in front of them or personal space on the upper chest. In order to assess modulations of sensory perception during movement preparation, event-related potentials (ERPs) were recorded in response to task-irrelevant visual and tactile probe stimuli delivered randomly at one of the goal locations of the movements. In line with previous neurophysiological findings, movement preparation modulated visual processing at the goal of a movement in peripersonal space. Movement preparation also modulated somatosensory processing at the movement goal in personal space. The findings demonstrate that tactile perception in personal space is subject to similar top-down sensory modulation by motor preparation as observed for visual stimuli presented in peripersonal space. These findings show for the first time that the principles and mechanisms underlying adaptive modulation of sensory processing in the context of action extend to tactile perception in unseen personal space. Copyright © 2016 Elsevier Ltd. All rights reserved.

An ancestral stomatal patterning module revealed in the non-vascular land plant Physcomitrella patens

PubMed Central

Chater, Caspar C.; Kamisugi, Yasuko

2016-01-01

The patterning of stomata plays a vital role in plant development and has emerged as a paradigm for the role of peptide signals in the spatial control of cellular differentiation. Research in Arabidopsis has identified a series of epidermal patterning factors (EPFs), which interact with an array of membrane-localised receptors and associated proteins (encoded by ERECTA and TMM genes) to control stomatal density and distribution. However, although it is well-established that stomata arose very early in the evolution of land plants, until now it has been unclear whether the established angiosperm stomatal patterning system represented by the EPF/TMM/ERECTA module reflects a conserved, universal mechanism in the plant kingdom. Here, we use molecular genetics to show that the moss Physcomitrella patens has conserved homologues of angiosperm EPF, TMM and at least one ERECTA gene that function together to permit the correct patterning of stomata and that, moreover, elements of the module retain function when transferred to Arabidopsis. Our data characterise the stomatal patterning system in an evolutionarily distinct branch of plants and support the hypothesis that the EPF/TMM/ERECTA module represents an ancient patterning system. PMID:27407102

The Female Predominance of a Vocational and Scientific Education Programme for High School Students in Rio de Janeiro and Recife, Brazil

ERIC Educational Resources Information Center

de Sousa, Isabela Cabral Felix; Braga, Cristiane Nogueira; Frutuoso, Telma de Mello; Ferreira, Cristina Araripe; Vargas, Diego da Silva

2008-01-01

The aim of this research is to understand how students view their volunteer choices to take part in a specific scientific education programme while they attend high school. This programme is called (Provoc) located at Oswaldo Cruz Foundation (Fiocruz), Brazil. Historically, this programme has been characterised by a significant predominance of…

Characterisation of Best Practices in the Development of Cross-Curricular Competences in Vocational Education and Training: Case Study in the Basque Country

ERIC Educational Resources Information Center

Eizagirre Sagardia, Ana; Imaz Bengoetxea, Jose Inazio; Rekalde Rodríguez, Itziar

2018-01-01

This paper presents the most important results of a research project aimed at gathering empirical evidence on current efforts to foster and develop cross-curricular competences (CCC) in Vocational Education and Training (VET) Centres located in the Basque Country (Spain). The case study research method was used, with data being gathered by means…

Cholinergic enhancement modulates neural correlates of selective attention and emotional processing.

PubMed

Bentley, Paul; Vuilleumier, Patrik; Thiel, Christiane M; Driver, Jon; Dolan, Raymond J

2003-09-01

Neocortical cholinergic afferents are proposed to influence both selective attention and emotional processing. In a study of healthy adults we used event-related fMRI while orthogonally manipulating attention and emotionality to examine regions showing effects of cholinergic modulation by the anticholinesterase physostigmine. Either face or house pictures appeared at task-relevant locations, with the alternative picture type at irrelevant locations. Faces had either neutral or fearful expressions. Physostigmine increased relative activity within the anterior fusiform gyrus for faces at attended, versus unattended, locations, but decreased relative activity within the posterolateral occipital cortex for houses in attended, versus unattended, locations. A similar pattern of regional differences in the effect of physostigmine on cue-evoked responses was also present in the absence of stimuli. Cholinergic enhancement augmented the relative neuronal response within the middle fusiform gyrus to fearful faces, whether at attended or unattended locations. By contrast, physostigmine influenced responses in the orbitofrontal, intraparietal and cingulate cortices to fearful faces when faces occupied task-irrelevant locations. These findings suggest that acetylcholine may modulate both selective attention and emotional processes through independent, region-specific effects within the extrastriate cortex. Furthermore, cholinergic inputs to the frontoparietal cortex may influence the allocation of attention to emotional information.

Accurate determination of segmented X-ray detector geometry

PubMed Central

Yefanov, Oleksandr; Mariani, Valerio; Gati, Cornelius; White, Thomas A.; Chapman, Henry N.; Barty, Anton

2015-01-01

Recent advances in X-ray detector technology have resulted in the introduction of segmented detectors composed of many small detector modules tiled together to cover a large detection area. Due to mechanical tolerances and the desire to be able to change the module layout to suit the needs of different experiments, the pixels on each module might not align perfectly on a regular grid. Several detectors are designed to permit detector sub-regions (or modules) to be moved relative to each other for different experiments. Accurate determination of the location of detector elements relative to the beam-sample interaction point is critical for many types of experiment, including X-ray crystallography, coherent diffractive imaging (CDI), small angle X-ray scattering (SAXS) and spectroscopy. For detectors with moveable modules, the relative positions of pixels are no longer fixed, necessitating the development of a simple procedure to calibrate detector geometry after reconfiguration. We describe a simple and robust method for determining the geometry of segmented X-ray detectors using measurements obtained by serial crystallography. By comparing the location of observed Bragg peaks to the spot locations predicted from the crystal indexing procedure, the position, rotation and distance of each module relative to the interaction region can be refined. We show that the refined detector geometry greatly improves the results of experiments. PMID:26561117

Avionics Architecture Standards as an Approach to Obsolescence Management

DTIC Science & Technology

2000-10-01

and goals is one method of system. The term System Architecture refers to a achieving the necessary critical mass of skilled and consistent set of such...Processing Module (GPM), Mass Memory Module executed on the modules within an ASAAC system will (MMM) and Power Conversion Module (PCM). be stored in a central...location, the Mass Memory * MOS -Module Support Layer to Operating System Module (MMM). Therefore, if modules are to be The purpose of the MOS

BoreholeAR: A mobile tablet application for effective borehole database visualization using an augmented reality technology

NASA Astrophysics Data System (ADS)

Lee, Sangho; Suh, Jangwon; Park, Hyeong-Dong

2015-03-01

Boring logs are widely used in geological field studies since the data describes various attributes of underground and surface environments. However, it is difficult to manage multiple boring logs in the field as the conventional management and visualization methods are not suitable for integrating and combining large data sets. We developed an iPad application to enable its user to search the boring log rapidly and visualize them using the augmented reality (AR) technique. For the development of the application, a standard borehole database appropriate for a mobile-based borehole database management system was designed. The application consists of three modules: an AR module, a map module, and a database module. The AR module superimposes borehole data on camera imagery as viewed by the user and provides intuitive visualization of borehole locations. The map module shows the locations of corresponding borehole data on a 2D map with additional map layers. The database module provides data management functions for large borehole databases for other modules. Field survey was also carried out using more than 100,000 borehole data.

Spatiotemporal reconstruction of auditory steady-state responses to acoustic amplitude modulations: Potential sources beyond the auditory pathway.

PubMed

Farahani, Ehsan Darestani; Goossens, Tine; Wouters, Jan; van Wieringen, Astrid

2017-03-01

Investigating the neural generators of auditory steady-state responses (ASSRs), i.e., auditory evoked brain responses, with a wide range of screening and diagnostic applications, has been the focus of various studies for many years. Most of these studies employed a priori assumptions regarding the number and location of neural generators. The aim of this study is to reconstruct ASSR sources with minimal assumptions in order to gain in-depth insight into the number and location of brain regions that are activated in response to low- as well as high-frequency acoustically amplitude modulated signals. In order to reconstruct ASSR sources, we applied independent component analysis with subsequent equivalent dipole modeling to single-subject EEG data (young adults, 20-30 years of age). These data were based on white noise stimuli, amplitude modulated at 4, 20, 40, or 80Hz. The independent components that exhibited a significant ASSR were clustered among all participants by means of a probabilistic clustering method based on a Gaussian mixture model. Results suggest that a widely distributed network of sources, located in cortical as well as subcortical regions, is active in response to 4, 20, 40, and 80Hz amplitude modulated noises. Some of these sources are located beyond the central auditory pathway. Comparison of brain sources in response to different modulation frequencies suggested that the identified brain sources in the brainstem, the left and the right auditory cortex show a higher responsiveness to 40Hz than to the other modulation frequencies. Copyright © 2017 Elsevier Inc. All rights reserved.

KENNEDY SPACE CENTER, FLA. - Various elements intended for the International Space Station are lined up in the Space Station Processing Facility. The newest to arrive at KSC are in the rear: at left, the U.S. Node 2, and at right, the Japanese Experiment Module (JEM). The two elements are undergoing a Multi-Element Integrated Test (MEIT). Node 2 attaches to the end of the U.S. Lab on the ISS and provides attach locations for the Japanese laboratory, European laboratory, the Centrifuge Accommodation Module and, eventually, Multipurpose Logistics Modules. It will provide the primary docking location for the Shuttle when a pressurized mating adapter is attached to Node 2. Installation of the module will complete the U.S. Core of the ISS. Developed by the National Space Development Agency of Japan (NASDA), the JEM is Japan's primary contribution to the Station. It will enhance the unique research capabilities of the orbiting complex by providing an additional environment for astronauts to conduct science experiments.

NASA Image and Video Library

2003-08-27

KENNEDY SPACE CENTER, FLA. - Various elements intended for the International Space Station are lined up in the Space Station Processing Facility. The newest to arrive at KSC are in the rear: at left, the U.S. Node 2, and at right, the Japanese Experiment Module (JEM). The two elements are undergoing a Multi-Element Integrated Test (MEIT). Node 2 attaches to the end of the U.S. Lab on the ISS and provides attach locations for the Japanese laboratory, European laboratory, the Centrifuge Accommodation Module and, eventually, Multipurpose Logistics Modules. It will provide the primary docking location for the Shuttle when a pressurized mating adapter is attached to Node 2. Installation of the module will complete the U.S. Core of the ISS. Developed by the National Space Development Agency of Japan (NASDA), the JEM is Japan's primary contribution to the Station. It will enhance the unique research capabilities of the orbiting complex by providing an additional environment for astronauts to conduct science experiments.

KENNEDY SPACE CENTER, FLA. - Various elements intended for the International Space Station are lined up in the Space Station Processing Facility. The newest to arrive at KSC are in the rear: at left, the U.S. Node 2, and next to it at right, the Japanese Experiment Module (JEM). The two elements are undergoing a Multi-Element Integrated Test (MEIT). Node 2 attaches to the end of the U.S. Lab on the ISS and provides attach locations for the Japanese laboratory, European laboratory, the Centrifuge Accommodation Module and, eventually, Multipurpose Logistics Modules. It will provide the primary docking location for the Shuttle when a pressurized mating adapter is attached to Node 2. Installation of the module will complete the U.S. Core of the ISS. Developed by the National Space Development Agency of Japan (NASDA), the JEM is Japan's primary contribution to the Station. It will enhance the unique research capabilities of the orbiting complex by providing an additional environment for astronauts to conduct science experiments.

NASA Image and Video Library

2003-09-03

KENNEDY SPACE CENTER, FLA. - Various elements intended for the International Space Station are lined up in the Space Station Processing Facility. The newest to arrive at KSC are in the rear: at left, the U.S. Node 2, and next to it at right, the Japanese Experiment Module (JEM). The two elements are undergoing a Multi-Element Integrated Test (MEIT). Node 2 attaches to the end of the U.S. Lab on the ISS and provides attach locations for the Japanese laboratory, European laboratory, the Centrifuge Accommodation Module and, eventually, Multipurpose Logistics Modules. It will provide the primary docking location for the Shuttle when a pressurized mating adapter is attached to Node 2. Installation of the module will complete the U.S. Core of the ISS. Developed by the National Space Development Agency of Japan (NASDA), the JEM is Japan's primary contribution to the Station. It will enhance the unique research capabilities of the orbiting complex by providing an additional environment for astronauts to conduct science experiments.

KENNEDY SPACE CENTER, FLA. - In the Space Station Processing Facility, the U.S. Node 2 (center) and the Japanese Experiment Module (JEM), background right, await a Multi-Element Integrated Test (MEIT). Node 2 attaches to the end of the U.S. Lab on the International Space Station and provides attach locations for the Japanese laboratory, European laboratory, the Centrifuge Accommodation Module and, eventually, Multipurpose Logistics Modules. It will provide the primary docking location for the Shuttle when a pressurized mating adapter is attached to Node 2. Installation of the module will complete the U.S. Core of the ISS. The National Space Development Agency of Japan (NASDA) developed their laboratory at the Tsukuba Space Center near Tokyo. It is the first element, named "Kibo" (Hope), to be delivered to KSC. The JEM is Japan's primary contribution to the Station. It will enhance the unique research capabilities of the orbiting complex by providing an additional environment for astronauts to conduct science experiments.

NASA Image and Video Library

2003-08-27

KENNEDY SPACE CENTER, FLA. - In the Space Station Processing Facility, the U.S. Node 2 (center) and the Japanese Experiment Module (JEM), background right, await a Multi-Element Integrated Test (MEIT). Node 2 attaches to the end of the U.S. Lab on the International Space Station and provides attach locations for the Japanese laboratory, European laboratory, the Centrifuge Accommodation Module and, eventually, Multipurpose Logistics Modules. It will provide the primary docking location for the Shuttle when a pressurized mating adapter is attached to Node 2. Installation of the module will complete the U.S. Core of the ISS. The National Space Development Agency of Japan (NASDA) developed their laboratory at the Tsukuba Space Center near Tokyo. It is the first element, named "Kibo" (Hope), to be delivered to KSC. The JEM is Japan's primary contribution to the Station. It will enhance the unique research capabilities of the orbiting complex by providing an additional environment for astronauts to conduct science experiments.

Changing selective pressure during antigenic changes in human influenza H3.

PubMed

Blackburne, Benjamin P; Hay, Alan J; Goldstein, Richard A

2008-05-02

The rapid evolution of influenza viruses presents difficulties in maintaining the optimal efficiency of vaccines. Amino acid substitutions result in antigenic drift, a process whereby antisera raised in response to one virus have reduced effectiveness against future viruses. Interestingly, while amino acid substitutions occur at a relatively constant rate, the antigenic properties of H3 move in a discontinuous, step-wise manner. It is not clear why this punctuated evolution occurs, whether this represents simply the fact that some substitutions affect these properties more than others, or if this is indicative of a changing relationship between the virus and the host. In addition, the role of changing glycosylation of the haemagglutinin in these shifts in antigenic properties is unknown. We analysed the antigenic drift of HA1 from human influenza H3 using a model of sequence change that allows for variation in selective pressure at different locations in the sequence, as well as at different parts of the phylogenetic tree. We detect significant changes in selective pressure that occur preferentially during major changes in antigenic properties. Despite the large increase in glycosylation during the past 40 years, changes in glycosylation did not correlate either with changes in antigenic properties or with significantly more rapid changes in selective pressure. The locations that undergo changes in selective pressure are largely in places undergoing adaptive evolution, in antigenic locations, and in locations or near locations undergoing substitutions that characterise the change in antigenicity of the virus. Our results suggest that the relationship of the virus to the host changes with time, with the shifts in antigenic properties representing changes in this relationship. This suggests that the virus and host immune system are evolving different methods to counter each other. While we are able to characterise the rapid increase in glycosylation of the haemagglutinin during time in human influenza H3, an increase not present in influenza in birds, this increase seems unrelated to the observed changes in antigenic properties.

Modular radiochemistry synthesis system

DOEpatents

Satyamurthy, Nagichettiar; Barrio, Jorge R.; Amarasekera, Bernard; Van Dam, Michael R.; Olma, Sebastian; Williams, Dirk; Eddings, Mark; Shen, Clifton Kwang-Fu

2016-11-01

A modular chemical production system includes multiple modules for performing a chemical reaction, particularly of radiochemical compounds, from a remote location. One embodiment comprises a reaction vessel including a moveable heat source with the position thereof relative to the reaction vessel being controllable from a remote position. Alternatively the heat source may be fixed in location and the reaction vial is moveable into and out of the heat source. The reaction vessel has one or more sealing plugs, the positioning of which in relationship to the reaction vessel is controllable from a remote position. Also the one or more reaction vessel sealing plugs can include one or more conduits there through for delivery of reactants, gases at atmospheric or an elevated pressure, inert gases, drawing a vacuum and removal of reaction end products to and from the reaction vial, the reaction vial with sealing plug in position being operable at elevated pressures. The modular chemical production system is assembled from modules which can each include operating condition sensors and controllers configured for monitoring and controlling the individual modules and the assembled system from a remote position. Other modules include, but are not limited to a Reagent Storage and Delivery Module, a Cartridge Purification Module, a Microwave Reaction Module, an External QC/Analysis/Purification Interface Module, an Aliquotting Module, an F-18 Drying Module, a Concentration Module, a Radiation Counting Module, and a Capillary Reactor Module.

Modular radiochemistry synthesis system

DOEpatents

Satyamurthy, Nagichettiar; Barrio, Jorge R.; Amarasekera, Bernard; Van Dam, R. Michael; Olma, Sebastian; Williams, Dirk; Eddings, Mark; Shen, Clifton Kwang-Fu

2015-12-15

A modular chemical production system includes multiple modules for performing a chemical reaction, particularly of radiochemical compounds, from a remote location. One embodiment comprises a reaction vessel including a moveable heat source with the position thereof relative to the reaction vessel being controllable from a remote position. Alternatively the heat source may be fixed in location and the reaction vial is moveable into and out of the heat source. The reaction vessel has one or more sealing plugs, the positioning of which in relationship to the reaction vessel is controllable from a remote position. Also the one or more reaction vessel sealing plugs can include one or more conduits there through for delivery of reactants, gases at atmospheric or an elevated pressure, inert gases, drawing a vacuum and removal of reaction end products to and from the reaction vial, the reaction vial with sealing plug in position being operable at elevated pressures. The modular chemical production system is assembled from modules which can each include operating condition sensors and controllers configured for monitoring and controlling the individual modules and the assembled system from a remote position. Other modules include, but are not limited to a Reagent Storage and Delivery Module, a Cartridge Purification Module, a Microwave Reaction Module, an External QC/Analysis/Purification Interface Module, an Aliquotting Module, an F-18 Drying Module, a Concentration Module, a Radiation Counting Module, and a Capillary Reactor Module.

Modular radiochemistry synthesis system

DOEpatents

Satyamurthy, Nagichettiar; Barrio, Jorge R; Amarasekera, Bernard; Van Dam, R. Michael; Olma, Sebastian; Williams, Dirk; Eddings, Mark A; Shen, Clifton Kwang-Fu

2015-02-10

A modular chemical production system includes multiple modules for performing a chemical reaction, particularly of radiochemical compounds, from a remote location. One embodiment comprises a reaction vessel including a moveable heat source with the position thereof relative to the reaction vessel being controllable from a remote position. Alternatively the heat source may be fixed in location and the reaction vial is moveable into and out of the heat source. The reaction vessel has one or more sealing plugs, the positioning of which in relationship to the reaction vessel is controllable from a remote position. Also the one or more reaction vessel sealing plugs can include one or more conduits there through for delivery of reactants, gases at atmospheric or an elevated pressure, inert gases, drawing a vacuum and removal of reaction end products to and from the reaction vial, the reaction vial with sealing plug in position being operable at elevated pressures. The modular chemical production system is assembled from modules which can each include operating condition sensors and controllers configured for monitoring and controlling the individual modules and the assembled system from a remote position. Other modules include, but are not limited to a Reagent Storage and Delivery Module, a Cartridge Purification Module, a Microwave Reaction Module, an External QC/Analysis/Purification Interface Module, an Aliquotting Module, an F-18 Drying Module, a Concentration Module, a Radiation Counting Module, and a Capillary Reactor Module.

Stable orbits for lunar landing assistance

NASA Astrophysics Data System (ADS)

Condoleo, Ennio; Cinelli, Marco; Ortore, Emiliano; Circi, Christian

2017-10-01

To improve lunar landing performances in terms of mission costs, trajectory determination and visibility the use of a single probe located over an assistance orbit around the Moon has been taken into consideration. To this end, the properties of two quasi-circular orbits characterised by a stable behaviour of semi-major axis, eccentricity and inclination have been investigated. The analysis has demonstrated the possibility of using an assistance probe, located over one of these orbits, as a relay satellite between lander and Earth, even in the case of landings on the far side of the Moon. A comparison about the accuracy in retrieving the lander's state with respect to the use of a probe located in the Lagrangian point L2 of the Earth-Moon system has also been carried out.

STS-98 Onboard Photograph-U.S. Laboratory, Destiny

NASA Technical Reports Server (NTRS)

2001-01-01

In the grasp of the Shuttle's Remote Manipulator System (RMS) robot arm, the U.S. Laboratory, Destiny, is moved from its stowage position in the cargo bay of the Space Shuttle Atlantis. This photograph was taken by astronaut Thomas D. Jones during his Extravehicular Activity (EVA). The American-made Destiny module is the cornerstone for space-based research aboard the orbiting platform and the centerpiece of the International Space Station (ISS), where unprecedented science experiments will be performed in the near-zero gravity of space. Destiny will also serve as the command and control center for the ISS. The aluminum module is 8.5- meters (28-feet) long and 4.3-meters (14-feet) in diameter. The laboratory consists of three cylindrical sections and two endcones with hatches that will be mated to other station components. A 50.9-centimeter- (20-inch-) diameter window is located on one side of the center module segment. This pressurized module is designed to accommodate pressurized payloads. It has a capacity of 24 rack locations. Payload racks will occupy 15 locations especially designed to support experiments. The Destiny module was built by the Boeing Company under the direction of the Marshall Space Flight Center.

STS-98 Onboard Photograph-U.S. Laboratory, Destiny

NASA Technical Reports Server (NTRS)

2001-01-01

In the grasp of the Shuttle's Remote Manipulator System (RMS) robot arm, the U.S. Laboratory, Destiny, is moved from its stowage position in the cargo bay of the Space Shuttle Atlantis. This photograph was taken by astronaut Thomas D. Jones during his Extravehicular Activity (EVA). The American-made Destiny module is the cornerstone for space-based research aboard the orbiting platform and the centerpiece of the International Space Station (ISS), where unprecedented science experiments will be performed in the near-zero gravity of space. Destiny will also serve as the command and control center for the ISS. The aluminum module is 8.5- meters (28-feet) long and 4.3-meters (14-feet) in diameter. The laboratory consists of three cylindrical sections and two endcones with hatches that will be mated to other station components. A 50.9-centimeter (20-inch-) diameter window is located on one side of the center module segment. This pressurized module is designed to accommodate pressurized payloads. It has a capacity of 24 rack locations. Payload racks will occupy 15 locations especially designed to support experiments. The Destiny module was built by the Boeing Company under the direction of the Marshall Space Flight Center.

STS-98 Onboard Photograph-U.S. Laboratory, Destiny

NASA Technical Reports Server (NTRS)

2001-01-01

With its new U.S. Laboratory, Destiny, contrasted over a blue and white Earth, the International Space Station (ISS) was photographed by one of the STS-98 crew members aboard the Space Shuttle Atlantis following separation of the Shuttle and Station. The Laboratory is shown at the lower right of the Station. The American-made Destiny module is the cornerstone for space-based research aboard the orbiting platform and the centerpiece of the ISS, where unprecedented science experiments will be performed in the near-zero gravity of space. Destiny will also serve as the command and control center for the ISS. The aluminum module is 8.5- meters (28-feet) long and 4.3-meters (14-feet) in diameter. The laboratory consists of three cylindrical sections and two endcones with hatches that will be mated to other station components. A 50.9-centimeter (20-inch-) diameter window is located on one side of the center module segment. This pressurized module is designed to accommodate pressurized payloads. It has a capacity of 24 rack locations. Payload racks will occupy 15 locations especially designed to support experiments. The Destiny module was built by the Boeing Company under the direction of the Marshall Space Flight Center.

International Space Station (ISS)

NASA Image and Video Library

2001-02-16

The International Space Station (ISS), with its newly attached U.S. Laboratory, Destiny, was photographed by a crew member aboard the Space Shuttle Orbiter Atlantis during a fly-around inspection after Atlantis separated from the Space Station. The Laboratory is shown in the foreground of this photograph. The American-made Destiny module is the cornerstone for space-based research aboard the orbiting platform and the centerpiece of the International Space Station (ISS), where unprecedented science experiments will be performed in the near-zero gravity of space. Destiny will also serve as the command and control center for the ISS. The aluminum module is 8.5-meters (28-feet) long and 4.3-meters (14-feet) in diameter. The laboratory consists of three cylindrical sections and two endcones with hatches that will be mated to other station components. A 50.9-centimeter (20-inch-) diameter window is located on one side of the center module segment. This pressurized module is designed to accommodate pressurized payloads. It has a capacity of 24 rack locations. Payload racks will occupy 15 locations especially designed to support experiments. The Destiny module was built by the Boeing Company under the direction of the Marshall Space Flight Center.

International Space Station (ISS)

NASA Image and Video Library

2001-02-16

With its new U.S. Laboratory, Destiny, contrasted over a blue and white Earth, the International Space Station (ISS) was photographed by one of the STS-98 crew members aboard the Space Shuttle Atlantis following separation of the Shuttle and Station. The Laboratory is shown at the lower right of the Station. The American-made Destiny module is the cornerstone for space-based research aboard the orbiting platform and the centerpiece of the ISS, where unprecedented science experiments will be performed in the near-zero gravity of space. Destiny will also serve as the command and control center for the ISS. The aluminum module is 8.5- meters (28-feet) long and 4.3-meters (14-feet) in diameter. The laboratory consists of three cylindrical sections and two endcones with hatches that will be mated to other station components. A 50.9-centimeter (20-inch-) diameter window is located on one side of the center module segment. This pressurized module is designed to accommodate pressurized payloads. It has a capacity of 24 rack locations. Payload racks will occupy 15 locations especially designed to support experiments. The Destiny module was built by the Boeing Company under the direction of the Marshall Space Flight Center.

International Space Station (ISS)

NASA Image and Video Library

2001-02-01

In the grasp of the Shuttle's Remote Manipulator System (RMS) robot arm, the U.S. Laboratory, Destiny, is moved from its stowage position in the cargo bay of the Space Shuttle Atlantis. This photograph was taken by astronaut Thomas D. Jones during his Extravehicular Activity (EVA). The American-made Destiny module is the cornerstone for space-based research aboard the orbiting platform and the centerpiece of the International Space Station (ISS), where unprecedented science experiments will be performed in the near-zero gravity of space. Destiny will also serve as the command and control center for the ISS. The aluminum module is 8.5- meters (28-feet) long and 4.3-meters (14-feet) in diameter. The laboratory consists of three cylindrical sections and two endcones with hatches that will be mated to other station components. A 50.9-centimeter (20-inch-) diameter window is located on one side of the center module segment. This pressurized module is designed to accommodate pressurized payloads. It has a capacity of 24 rack locations. Payload racks will occupy 15 locations especially designed to support experiments. The Destiny module was built by the Boeing Company under the direction of the Marshall Space Flight Center.

International Space Station (ISS)

NASA Image and Video Library

2001-02-01

In the grasp of the Shuttle's Remote Manipulator System (RMS) robot arm, the U.S. Laboratory, Destiny, is moved from its stowage position in the cargo bay of the Space Shuttle Atlantis. This photograph was taken by astronaut Thomas D. Jones during his Extravehicular Activity (EVA). The American-made Destiny module is the cornerstone for space-based research aboard the orbiting platform and the centerpiece of the International Space Station (ISS), where unprecedented science experiments will be performed in the near-zero gravity of space. Destiny will also serve as the command and control center for the ISS. The aluminum module is 8.5- meters (28-feet) long and 4.3-meters (14-feet) in diameter. The laboratory consists of three cylindrical sections and two endcones with hatches that will be mated to other station components. A 50.9-centimeter- (20-inch-) diameter window is located on one side of the center module segment. This pressurized module is designed to accommodate pressurized payloads. It has a capacity of 24 rack locations. Payload racks will occupy 15 locations especially designed to support experiments. The Destiny module was built by the Boeing Company under the direction of the Marshall Space Flight Center.

Method of and system for classifying emergency locating transmitters and emergency positions indicating radio beacons

NASA Technical Reports Server (NTRS)

Wren, Paul E. (Inventor)

1983-01-01

During a distress call, a distress location transmitter 10 generates a high frequency carrier signal 40 that is modulated by a predetermined distress waveform characteristic 29. The classification of user associated with the distress call is identified by periodically interrupting modulation 42; user classification is determined by the repetition rate of the interruptions, the interruption periods, or both.

Location. Unit 9. Level 1. Instructor Guide. PACE: Program for Acquiring Competence in Entrepreneurship. Third Edition. Research & Development Series No. 301-09.

ERIC Educational Resources Information Center

Ohio State Univ., Columbus. Center on Education and Training for Employment.

This instructor guide for a unit on locating a business in the PACE (Program for Acquiring Competence in Entrepreneurship) curriculum includes the full text of the student module and lesson plans, instructional suggestions, and other teacher resources. The competencies that are incorporated into this module are at Level 1 of…

Location. Unit 9. Level 2. Instructor Guide. PACE: Program for Acquiring Competence in Entrepreneurship. Third Edition. Research & Development Series No. 302-09.

ERIC Educational Resources Information Center

Ohio State Univ., Columbus. Center on Education and Training for Employment.

This instructor guide for a unit on locating a business in the PACE (Program for Acquiring Competence in Entrepreneurship) curriculum includes the full text of the student module and lesson plans, instructional suggestions, and other teacher resources. The competencies that are incorporated into this module are at Level 2 of learning--planning for…

Location. Unit 9. Level 3. Instructor Guide. PACE: Program for Acquiring Competence in Entrepreneurship. Third Edition. Research & Development Series No. 303-09.

ERIC Educational Resources Information Center

Ohio State Univ., Columbus. Center on Education and Training for Employment.

This instructor guide for a unit on location in the PACE (Program for Acquiring Competence in Entrepreneurship) curriculum includes the full text of the student module and lesson plans, instructional suggestions, and other teacher resources. The competencies that are incorporated into this module are at Level 3 of learning--starting and managing…

Spatially tuned normalization explains attention modulation variance within neurons.

PubMed

Ni, Amy M; Maunsell, John H R

2017-09-01

Spatial attention improves perception of attended parts of a scene, a behavioral enhancement accompanied by modulations of neuronal firing rates. These modulations vary in size across neurons in the same brain area. Models of normalization explain much of this variance in attention modulation with differences in tuned normalization across neurons (Lee J, Maunsell JHR. PLoS One 4: e4651, 2009; Ni AM, Ray S, Maunsell JHR. Neuron 73: 803-813, 2012). However, recent studies suggest that normalization tuning varies with spatial location both across and within neurons (Ruff DA, Alberts JJ, Cohen MR. J Neurophysiol 116: 1375-1386, 2016; Verhoef BE, Maunsell JHR. eLife 5: e17256, 2016). Here we show directly that attention modulation and normalization tuning do in fact covary within individual neurons, in addition to across neurons as previously demonstrated. We recorded the activity of isolated neurons in the middle temporal area of two rhesus monkeys as they performed a change-detection task that controlled the focus of spatial attention. Using the same two drifting Gabor stimuli and the same two receptive field locations for each neuron, we found that switching which stimulus was presented at which location affected both attention modulation and normalization in a correlated way within neurons. We present an equal-maximum-suppression spatially tuned normalization model that explains this covariance both across and within neurons: each stimulus generates equally strong suppression of its own excitatory drive, but its suppression of distant stimuli is typically less. This new model specifies how the tuned normalization associated with each stimulus location varies across space both within and across neurons, changing our understanding of the normalization mechanism and how attention modulations depend on this mechanism. NEW & NOTEWORTHY Tuned normalization studies have demonstrated that the variance in attention modulation size seen across neurons from the same cortical area can be largely explained by between-neuron differences in normalization strength. Here we demonstrate that attention modulation size varies within neurons as well and that this variance is largely explained by within-neuron differences in normalization strength. We provide a new spatially tuned normalization model that explains this broad range of observed normalization and attention effects. Copyright © 2017 the American Physiological Society.

Programmable phase plate for tool modification in laser machining applications

DOEpatents

Thompson Jr., Charles A.; Kartz, Michael W.; Brase, James M.; Pennington, Deanna; Perry, Michael D.

2004-04-06

A system for laser machining includes a laser source for propagating a laser beam toward a target location, and a spatial light modulator having individual controllable elements capable of modifying a phase profile of the laser beam to produce a corresponding irradiance pattern on the target location. The system also includes a controller operably connected to the spatial light modulator for controlling the individual controllable elements. By controlling the individual controllable elements, the phase profile of the laser beam may be modified into a desired phase profile so as to produce a corresponding desired irradiance pattern on the target location capable of performing a machining operation on the target location.

Characterising flow regime and interrelation between surface-water and ground-water in the Fuente de Piedra salt lake basin by means of stable isotopes, hydrogeochemical and hydraulic data

NASA Astrophysics Data System (ADS)

Kohfahl, Claus; Rodriguez, Miguel; Fenk, Cord; Menz, Christian; Benavente, Jose; Hubberten, Hans; Meyer, Hanno; Paul, Liisa; Knappe, Andrea; López-Geta, Juan Antonio; Pekdeger, Asaf

2008-03-01

SummaryThis research reports the characterisation of ground- and surface-water interaction in the Fuente de Piedra Salt lake basin in southern Spain by a combined approach using hydraulic, hydrogeochemical and stable isotope data. During three sampling campaigns (February 2004, 2005 and October 2005) ground- and surface-water samples were collected for stable isotope studies ( 18O, D) and for major and minor ion analysis. Hydraulic measurements at multilevel piezometers were carried out at four different locations around the lake edge. Conductivity logs were performed at four piezometers located along a profile at the northern lake border and at two deeper piezometers in the Miocene basin at a greater distance from the lake. To describe processes that control the brine evolution different hydrogeochemical simulations were performed. Hydrogeochemical data show a variety of brines related to thickness variations of lacustrine evaporites around the lake. Salinity profiles in combination with stable isotope and hydraulic data indicate the existence of convection cells and recycled brines. Furthermore restricted ground-water inflow into the lake was detected. Dedolomitisation processes were identified by hydrogeochemical simulations and different brine origins were reproduced by inverse modelling approaches.

Characterisation of the Subaquatic Groundwater Discharge That Maintains the Permanent Stratification within Lake Kivu; East Africa

PubMed Central

Ross, Kelly Ann; Gashugi, Elisée; Gafasi, Augustin; Wüest, Alfred; Schmid, Martin

2015-01-01

Warm and cold subaquatic groundwater discharge into Lake Kivu forms the large-scale density gradients presently observed in the lake. This structure is pertinent to maintaining the stratification that locks the high volume of gases in the deepwater. Our research presents the first characterisation of these inflows. Temperature and conductivity profiling was conducted from January 2010 to March 2013 to map the locations of groundwater discharge. Water samples were obtained within the lake at the locations of the greatest temperature anomalies observed from the background lake-profile. The isotopic and chemical signatures of the groundwater were applied to assess how these inflows contribute to the overall stratification. It is inferred that Lake Kivu’s deepwater has not been completely recharged by the groundwater inflows since its turnover that is speculated to have occurred within the last ~1000 yrs. Given a recent salinity increase in the lake constrained to within months of seismic activity measured beneath the basin, it is plausible that increased hydrothermal-groundwater inflows into the deep basin are correlated with episodic geologic events. These results invalidate the simple two-component end-member mixing regime that has been postulated up to now, and indicate the importance of monitoring this potentially explosive lake. PMID:25799098

Attention operates uniformly throughout the classical receptive field and the surround.

PubMed

Verhoef, Bram-Ernst; Maunsell, John Hr

2016-08-22

Shifting attention among visual stimuli at different locations modulates neuronal responses in heterogeneous ways, depending on where those stimuli lie within the receptive fields of neurons. Yet how attention interacts with the receptive-field structure of cortical neurons remains unclear. We measured neuronal responses in area V4 while monkeys shifted their attention among stimuli placed in different locations within and around neuronal receptive fields. We found that attention interacts uniformly with the spatially-varying excitation and suppression associated with the receptive field. This interaction explained the large variability in attention modulation across neurons, and a non-additive relationship among stimulus selectivity, stimulus-induced suppression and attention modulation that has not been previously described. A spatially-tuned normalization model precisely accounted for all observed attention modulations and for the spatial summation properties of neurons. These results provide a unified account of spatial summation and attention-related modulation across both the classical receptive field and the surround.

Ring modulator small-signal response analysis based on pole-zero representation.

PubMed

Karimelahi, Samira; Sheikholeslami, Ali

2016-04-04

We present a closed-form expression for the small-signal response of a depletion-mode ring modulator and verify it by measurement results. Both electrical and optical behavior of micro-ring modulator as well as the loss variation due to the index modulation is considered in the derivation. This expression suggests that a ring modulator is a third-order system with one real pole, one zero and a pair of complex-conjugate poles. The exact positions of the poles/zero are given and shown to be dependent upon parameters such as electrical bandwidth, coupling condition, optical loss, and sign/value of laser detunings. We show that the location of zero is different for positive and negative detuning, and therefore, the ring modulator frequency response is asymmetric. We use the gain-bandwidth product as a figure of merit and calculate it for various pole/zero locations. We show that gain-bandwidth for the over-coupled ring modulator is superior compared to other coupling conditions. Also, we show that the gain-bandwidth product can be increased to a limit by increasing the electrical bandwidth.

Reducing tilt-to-length coupling for the LISA test mass interferometer

NASA Astrophysics Data System (ADS)

Tröbs, M.; Schuster, S.; Lieser, M.; Zwetz, M.; Chwalla, M.; Danzmann, K.; Fernández Barránco, G.; Fitzsimons, E. D.; Gerberding, O.; Heinzel, G.; Killow, C. J.; Perreur-Lloyd, M.; Robertson, D. I.; Schwarze, T. S.; Wanner, G.; Ward, H.

2018-05-01

Objects sensed by laser interferometers are usually not stable in position or orientation. This angular instability can lead to a coupling of angular tilt to apparent longitudinal displacement—tilt-to-length coupling (TTL). In LISA this is a potential noise source for both the test mass interferometer and the long-arm interferometer. We have experimentally investigated TTL coupling in a setup representative for the LISA test mass interferometer and used this system to characterise two different imaging systems (a two-lens design and a four-lens design) both designed to minimise TTL coupling. We show that both imaging systems meet the LISA requirement of  ±25 μm rad‑1 for interfering beams with relative angles of up to  ±300 μrad. Furthermore, we found a dependency of the TTL coupling on beam properties such as the waist size and location, which we characterised both theoretically and experimentally.

Solvent relaxation of fluorescent labels as a new tool for the detection of polarity and rigidity changes in membranes

NASA Astrophysics Data System (ADS)

Hof, Martin; Hutterer, Rudi

1998-04-01

Since solvent relaxation (SR) exclusively depends on the physical properties of the dye environment, SR spectroscopy of defined located labels in amphiphilic assemblies accomplishes the characterisation of specific domains. The most accurate way to characterise SR is the determination of the time-dependent Stokes shift. The time course of the Stokes shift, expressed as a solvent relaxation time, gives information about both the rigidity and polarity of the dye environment. The absolute value of the Stokes shift following the excitation is correlated with the polarity of the probed region. The validity of this approach for the investigation of phospholipid bilayers is illustrated by listing the parameters influencing the SR kinetics of appropriate membrane labels: membrane curvature, percentage of phosphatidylserine (PS) in small unilamell vesicles (SUV), addition of Ca2+ ions, binding of vitamin-K dependent proteins, percentage of diether-lipids in phosphatidylcholine (PC)-vesicles, and temperature.

Characterization of building materials from the aqueduct of Antioch-on-the-Orontes (Turkey)

NASA Astrophysics Data System (ADS)

Benjelloun, Yacine; de Sigoyer, Julia; Carlut, Julie; Hubert-Ferrari, Aurélia; Dessales, Hélène; Pamir, Hatice; Karabacak, Volkan

2015-07-01

The Roman aqueduct of Antioch-on-the-Orontes (Turkey), a city located near the junction between the active Dead Sea fault and the East Anatolian fault, has been damaged several times due to historical earthquakes, as mentioned in ancient texts. The traces of repairs are studied in order to identify their potential seismic origin. The deformations of the structure were characterised thanks to a LIDAR scan. Several bricks were sampled on different parts of the city's aqueducts, on the original structure and on repaired parts. The bricks were characterized through a petrological approach. 14C and archaeomagnetism were tested on the bricks in order to constrain the age of their production. The synthesis of all the data showed a local origin for the bricks, and led to the identification of several manufacturing techniques and several types of production, thus, confirming the potentiality of this approach to date and characterise post-seismic repairs.

Sheet metals characterization using the virtual fields method

NASA Astrophysics Data System (ADS)

Marek, Aleksander; Davis, Frances M.; Pierron, Fabrice

2018-05-01

In this work, a characterisation method involving a deep-notched specimen subjected to a tensile loading is introduced. This specimen leads to heterogeneous states of stress and strain, the latter being measured using a stereo DIC system (MatchID). This heterogeneity enables the identification of multiple material parameters in a single test. In order to identify material parameters from the DIC data, an inverse method called the Virtual Fields Method is employed. The method combined with recently developed sensitivity-based virtual fields allows to optimally locate areas in the test where information about each material parameter is encoded, improving accuracy of the identification over the traditional user-defined virtual fields. It is shown that a single test performed at 45° to the rolling direction is sufficient to obtain all anisotropic plastic parameters, thus reducing experimental effort involved in characterisation. The paper presents the methodology and some numerical validation.

The BepiColombo Laser Altimeter (BeLA) power converter module (PCM): Concept and characterisation.

PubMed

Rodrigo, J; Gasquet, E; Castro, J-M; Herranz, M; Lara, L-M; Muñoz, M; Simon, A; Behnke, T; Thomas, N

2017-03-01

This paper presents the principal considerations when designing DC-DC converters for space instruments, in particular for the power converter module as part of the first European space laser altimeter: "BepiColombo Laser Altimeter" on board the European Space Agency-Japan Aerospace Exploration Agency (JAXA) mission BepiColombo. The main factors which determine the design of the DC-DC modules in space applications are printed circuit board occupation, mass, DC-DC converter efficiency, and environmental-survivability constraints. Topics included in the appropriated DC-DC converter design flow are hereby described. The topology and technology for the primary and secondary stages, input filters, transformer design, and peripheral components are discussed. Component selection and design trade-offs are described. Grounding, load and line regulation, and secondary protection circuitry (under-voltage, over-voltage, and over-current) are then introduced. Lastly, test results and characterization of the final flight design are also presented. Testing of the inrush current, the regulated output start-up, and the switching function of the power supply indicate that these performances are fully compliant with the requirements.

Server rack for improved data center management

DOEpatents

Bermudez Rodriguez, Sergio A.; Hamann, Hendrik F.; Wehle, Hans-Dieter

2018-01-09

Methods and systems for data center management include collecting sensor data from one or more sensors in a rack; determining a location and identifying information for each asset in the rack using a set of asset tags associated with respective assets; communicating the sensor and asset location to a communication module; receiving an instruction from the communication module; and executing the received instruction to change a property of the rack.

Accurate determination of segmented X-ray detector geometry

DOE PAGES

Yefanov, Oleksandr; Mariani, Valerio; Gati, Cornelius; ...

2015-10-22

Recent advances in X-ray detector technology have resulted in the introduction of segmented detectors composed of many small detector modules tiled together to cover a large detection area. Due to mechanical tolerances and the desire to be able to change the module layout to suit the needs of different experiments, the pixels on each module might not align perfectly on a regular grid. Several detectors are designed to permit detector sub-regions (or modules) to be moved relative to each other for different experiments. Accurate determination of the location of detector elements relative to the beam-sample interaction point is critical formore » many types of experiment, including X-ray crystallography, coherent diffractive imaging (CDI), small angle X-ray scattering (SAXS) and spectroscopy. For detectors with moveable modules, the relative positions of pixels are no longer fixed, necessitating the development of a simple procedure to calibrate detector geometry after reconfiguration. We describe a simple and robust method for determining the geometry of segmented X-ray detectors using measurements obtained by serial crystallography. By comparing the location of observed Bragg peaks to the spot locations predicted from the crystal indexing procedure, the position, rotation and distance of each module relative to the interaction region can be refined. Furthermore, we show that the refined detector geometry greatly improves the results of experiments.« less

An improved method to characterise the modulation of small-scale turbulent by large-scale structures

NASA Astrophysics Data System (ADS)

Agostini, Lionel; Leschziner, Michael; Gaitonde, Datta

2015-11-01

A key aspect of turbulent boundary layer dynamics is ``modulation,'' which refers to degree to which the intensity of coherent large-scale structures (LS) cause an amplification or attenuation of the intensity of the small-scale structures (SS) through large-scale-linkage. In order to identify the variation of the amplitude of the SS motion, the envelope of the fluctuations needs to be determined. Mathis et al. (2009) proposed to define this latter by low-pass filtering the modulus of the analytic signal built from the Hilbert transform of SS. The validity of this definition, as a basis for quantifying the modulated SS signal, is re-examined on the basis of DNS data for a channel flow. The analysis shows that the modulus of the analytic signal is very sensitive to the skewness of its PDF, which is dependent, in turn, on the sign of the LS fluctuation and thus of whether these fluctuations are associated with sweeps or ejections. The conclusion is that generating an envelope by use of a low-pass filtering step leads to an important loss of information associated with the effects of the local skewness of the PDF of the SS on the modulation process. An improved Hilbert-transform-based method is proposed to characterize the modulation of SS turbulence by LS structures

Interactions between target location and reward size modulate the rate of microsaccades in monkeys

PubMed Central

Tokiyama, Stefanie; Lisberger, Stephen G.

2015-01-01

We have studied how rewards modulate the occurrence of microsaccades by manipulating the size of an expected reward and the location of the cue that sets the expectations for future reward. We found an interaction between the size of the reward and the location of the cue. When monkeys fixated on a cue that signaled the size of future reward, the frequency of microsaccades was higher if the monkey expected a large vs. a small reward. When the cue was presented at a site in the visual field that was remote from the position of fixation, reward size had the opposite effect: the frequency of microsaccades was lower when the monkey was expecting a large reward. The strength of pursuit initiation also was affected by reward size and by the presence of microsaccades just before the onset of target motion. The gain of pursuit initiation increased with reward size and decreased when microsaccades occurred just before or after the onset of target motion. The effect of the reward size on pursuit initiation was much larger than any indirect effects reward might cause through modulation of the rate of microsaccades. We found only a weak relationship between microsaccade direction and the location of the exogenous cue relative to fixation position, even in experiments where the location of the cue indicated the direction of target motion. Our results indicate that the expectation of reward is a powerful modulator of the occurrence of microsaccades, perhaps through attentional mechanisms. PMID:26311180

Clinical and molecular genetic characterisation of a family segregating autosomal dominant retinitis pigmentosa and sensorineural deafness.

PubMed

Kenna, P; Mansergh, F; Millington-Ward, S; Erven, A; Kumar-Singh, R; Brennan, R; Farrar, G J; Humphries, P

1997-03-01

To characterise clinically a large kindred segregating retinitis pigmentosa and sensorineural hearing impairment in an autosomal dominant pattern and perform genetic linkage studies in this family. Extensive linkage analysis in this family had previously excluded the majority of loci shown to be involved in the aetiologies of RP, some other forms of inherited retinal degeneration, and inherited deafness. Members of the family were subjected to detailed ophthalmic and audiological assessment. In addition, some family members underwent skeletal muscle biopsy, electromyography, and electrocardiography. Linkage analysis using anonymous microsatellite markers was performed on DNA samples from all living members of the pedigree. Patients in this kindred have a retinopathy typical of retinitis pigmentosa in addition to a hearing impairment. Those members of the pedigree examined demonstrated a subclinical myopathy, as evidence by abnormal skeletal muscle histology, electromyography, and electrocardiography. LOD scores of Zmax = 3.75 (theta = 0.10), Zmax = 3.41 (theta = 0.10), and Zmax = 3.25 (theta = 0.15) respectively were obtained with the markers D9S118, D9S121, and ASS, located on chromosome 9q34-qter, suggesting that the causative gene in this family may lie on the long arm (q) of chromosome 9. These data indicate that the gene responsible for the phenotype in this kindred is located on chromosome 9 q. These data, together with evidence that a murine deafness gene is located in a syntenic area of the mouse genome, should direct the research community to consider this area as a candidate region for retinopathy and/or deafness genes.

A Chromosome 7 Pericentric Inversion Defined at Single-Nucleotide Resolution Using Diagnostic Whole Genome Sequencing in a Patient with Hand-Foot-Genital Syndrome.

PubMed

Watson, Christopher M; Crinnion, Laura A; Harrison, Sally M; Lascelles, Carolina; Antanaviciute, Agne; Carr, Ian M; Bonthron, David T; Sheridan, Eamonn

2016-01-01

Next generation sequencing methodologies are facilitating the rapid characterisation of novel structural variants at nucleotide resolution. These approaches are particularly applicable to variants initially identified using alternative molecular methods. We report a child born with bilateral postaxial syndactyly of the feet and bilateral fifth finger clinodactyly. This was presumed to be an autosomal recessive syndrome, due to the family history of consanguinity. Karyotype analysis revealed a homozygous pericentric inversion of chromosome 7 (46,XX,inv(7)(p15q21)x2) which was confirmed to be heterozygous in both unaffected parents. Since the resolution of the karyotype was insufficient to identify any putatively causative gene, we undertook medium-coverage whole genome sequencing using paired-end reads, in order to elucidate the molecular breakpoints. In a two-step analysis, we first narrowed down the region by identifying discordant read-pairs, and then determined the precise molecular breakpoint by analysing the mapping locations of "soft-clipped" breakpoint-spanning reads. PCR and Sanger sequencing confirmed the identified breakpoints, both of which were located in intergenic regions. Significantly, the 7p15 breakpoint was located 523 kb upstream of HOXA13, the locus for hand-foot-genital syndrome. By inference from studies of HOXA locus control in the mouse, we suggest that the inversion has delocalised a HOXA13 enhancer to produce the phenotype observed in our patient. This study demonstrates how modern genetic diagnostic approach can characterise structural variants at nucleotide resolution and provide potential insights into functional regulation.

Animated analysis of geoscientific datasets: An interactive graphical application

NASA Astrophysics Data System (ADS)

Morse, Peter; Reading, Anya; Lueg, Christopher

2017-12-01

Geoscientists are required to analyze and draw conclusions from increasingly large volumes of data. There is a need to recognise and characterise features and changing patterns of Earth observables within such large datasets. It is also necessary to identify significant subsets of the data for more detailed analysis. We present an innovative, interactive software tool and workflow to visualise, characterise, sample and tag large geoscientific datasets from both local and cloud-based repositories. It uses an animated interface and human-computer interaction to utilise the capacity of human expert observers to identify features via enhanced visual analytics. 'Tagger' enables users to analyze datasets that are too large in volume to be drawn legibly on a reasonable number of single static plots. Users interact with the moving graphical display, tagging data ranges of interest for subsequent attention. The tool provides a rapid pre-pass process using fast GPU-based OpenGL graphics and data-handling and is coded in the Quartz Composer visual programing language (VPL) on Mac OSX. It makes use of interoperable data formats, and cloud-based (or local) data storage and compute. In a case study, Tagger was used to characterise a decade (2000-2009) of data recorded by the Cape Sorell Waverider Buoy, located approximately 10 km off the west coast of Tasmania, Australia. These data serve as a proxy for the understanding of Southern Ocean storminess, which has both local and global implications. This example shows use of the tool to identify and characterise 4 different types of storm and non-storm events during this time. Events characterised in this way are compared with conventional analysis, noting advantages and limitations of data analysis using animation and human interaction. Tagger provides a new ability to make use of humans as feature detectors in computer-based analysis of large-volume geosciences and other data.

Detection and characterisation of anthropogenic pieces by magnetic method

NASA Astrophysics Data System (ADS)

Nodot, Emilie; Munschy, Marc; Benevent, Pierre

2013-04-01

Human activities have let many anthropogenic objects buried under our feet. Some of these like explosive devices left after the World Wars turn out to be a threat to safety or environment. Others must be perfectly localised in case of construction work, for example gas pipe. Geophysics and more specifically magnetic cartography (many of these items are magnetic) can obviously help to locate them. We already use this method on daily basis to detect UXO (unexploded ordnance) but less than 10% of the unearthed objects are actually bombs or shells. Detection and mostly characterisation methods must be improved in order to reduce this proportion. On the field there are a few things we can do to increase data qualities. Characterisation may be improved by multiple scale prospections. We search a large area with our usual and rather fast method then we achieve high definition cartographies of small interesting areas (upon the object to characterise). In the case of measurements in an urban environment for example, data are distorted. The traffic (train, tramway, cars…) produces temporal variations of the magnetic field. This effect can be lessened, sometimes even removed by the use of a fixed scalar magnetic sensor. Data treatment is another key as regards the characterisation. Tools such as analytic signal or derivative are frequently used at the first degree. We will see that in a synthetic case the second and third degree bring even more information. A new issue appeared recently about pipes. Can we localise very precisely (less than 10 cm uncertainty) a gas pipe? Horizontally we can but due to our inversion method we still have troubles with the depth accuracy. Our final concern is about the amplitude of some anomalies. Potential methods equations are based on the fact that the anomaly norm must be minor to magnetic field norm. Sometimes this is not the case but vector magnetometry is a lead to solve this problem.

Impaired color word processing at an unattended location: evidence from a Stroop task combined with inhibition of return.

PubMed

Choi, Jong Moon; Cho, Yang Seok; Proctor, Robert W

2009-09-01

A Stroop task with separate color bar and color word stimuli was combined with an inhibition-of-return procedure to examine whether visual attention modulates color word processing. In Experiment 1, the color bar was presented at the cued location and the color word at the uncued location, or vice versa, with a 100- or 1,050-msec stimulus onset asynchrony (SOA) between cue and Stroop stimuli. In Experiment 2, on Stroop trials, the color bar was presented at a central fixated location and the color word at a cued or uncued location above or below the color bar. In both experiments, with a 100-msec SOA, the Stroop effect was numerically larger when the color word was displayed at the cued location than when it was displayed at the uncued location, but with the 1,050-msec SOA, this relation between Stroop effect magnitude and location was reversed. These results provide evidence that processing of the color word in the Stroop task is modulated by the location to which visual attention is directed.

Milk thistle: a future potential anti-osteoporotic and fracture healing agent.

PubMed

Mohd Fozi, Nur Farhana; Mazlan, Mazliadiyana; Shuid, Ahmad Nazrun; Isa Naina, Mohamed

2013-12-01

Osteoporosis is a progressive disease of the skeleton characterised by bone fragility due to a reduction in bone mass and possibly to alteration in bone architecture that lead to a propensity to fracture with minimum trauma. Most osteoporotic fractures occur at locations rich in trabecular or cancellous bone and usually related to post menopausal women. Recently, silymarin received attention due to its alternative beneficial effect on bone formation. It is a mixture of flavonoids with powerful antioxidant properties. This review focuses on the use of milk thistle or silymarin for the treatment of osteoporosis that may be related to fracture bone. Silymarin shows potent antioxidant herb that may modulate multiple genes in favour of helping to build bone and prevent bone loss. In the mouse fracture healing model, silymarin supplementation improved tibial healing with elevated BMD and serum levels of ALP and osteocalcin. Silymarin also demonstrated clear estrogenic antiosteoporotic effects in bone structure. Silymarin appears to play a crucial role to prevent bone loss and might regulate osteogenesis and may be beneficial for fracture healing. If silymarin is considered for the use of post menopausal women, it may be used for the treatment of osteoporosis. It would be of great benefit to postmenopausal women to develop an oestrogen antagonist that is as potent and efficacious as oestrogen in preventing bone loss without the major side effect associated with HRT.

Analysis and design of the Multimission Modular Spacecraft hydrazine propulsion module

NASA Technical Reports Server (NTRS)

Etheridge, F. G.; Woodruff, W. L.

1978-01-01

The translational velocity increment, stabilization and control requirements, vehicle weight, and geometric considerations of the Multimission Modular Spacecraft (MMS) provided the basic data on which to initiate the analysis and design of the hydrazine propulsion modules. The Landsat D was used as the mission model. Tradeoff studies were conducted on thrust level, thruster location, and clustering arrangement together with tankage volume and location. The impact of the use of single and dual seat thruster valves on plumbing configuration, reliability, and overall system cost was studied in detail. Conceptual designs of a recommended propulsion module configuration for both the Delta 3910 and Shuttle were prepared.

Wireless tracking of cotton modules Part II: automatic machine identification and system testing

USDA-ARS?s Scientific Manuscript database

Mapping the harvest location of cotton modules is essential to practical understanding and utilization of spatial-variability information in fiber quality. A wireless module-tracking system was recently developed, but automation of the system is required before it will find practical use on the far...

Maintenance on the Advanced Colloids Experiment Module

NASA Image and Video Library

2018-04-16

iss055e035366 (April 16, 2018) --- NASA astronaut Ricky Arnold performs maintenance on the Advanced Colloids Experiment Module located inside the Light Microscopy Module which is a modified commercial, highly flexible, state-of-the-art light imaging microscope facility that provides researchers with powerful diagnostic hardware and software in microgravity.

Multivariate thermo-hygrometric characterisation of the archaeological site of Plaza de l'Almoina (Valencia, Spain) for preventive conservation.

PubMed

Fernández-Navajas, Angel; Merello, Paloma; Beltrán, Pedro; García-Diego, Fernando-Juan

2013-07-29

Preventive conservation requires monitoring and control of the parameters involved in the deterioration process, mainly temperature and relative humidity. It is important to characterise an archaeological site prior to carrying out comparative studies in the future for preventive conservation, either by regular studies to verify whether the conditions are constant, or occasional ones when the boundary conditions are altered. There are numerous covered archaeological sites, but few preventive conservation works that give special attention to the type of cover installed. In particular, there is no background of microclimatic studies in sites that are in the ground and, as in the Plaza de l'Almoina (Valencia, Spain), are buried and partially covered by a transparent roof. A large effect of the transparent cover was found by the sensors located below this area, with substantial increases in temperature and a decrease in the relative humidity during the day. Surrounding zones also have values above the recommended temperature values. On the other hand, the influence of a buried water drainage line near the site is notable, causing an increase in relative humidity levels in the surrounding areas. Multivariate statistical analyses enabled us to characterise the microclimate of the archaeological site, allowing future testing to determine whether the conservation conditions have been altered.

Multivariate Thermo-Hygrometric Characterisation of the Archaeological Site of Plaza de l’Almoina (Valencia, Spain) for Preventive Conservation

PubMed Central

Fernández-Navajas, Ángel; Merello, Paloma; Beltrán, Pedro; García-Diego, Fernando-Juan

2013-01-01

Preventive conservation requires monitoring and control of the parameters involved in the deterioration process, mainly temperature and relative humidity. It is important to characterise an archaeological site prior to carrying out comparative studies in the future for preventive conservation, either by regular studies to verify whether the conditions are constant, or occasional ones when the boundary conditions are altered. There are numerous covered archaeological sites, but few preventive conservation works that give special attention to the type of cover installed. In particular, there is no background of microclimatic studies in sites that are in the ground and, as in the Plaza de l’Almoina (Valencia, Spain), are buried and partially covered by a transparent roof. A large effect of the transparent cover was found by the sensors located below this area, with substantial increases in temperature and a decrease in the relative humidity during the day. Surrounding zones also have values above the recommended temperature values. On the other hand, the influence of a buried water drainage line near the site is notable, causing an increase in relative humidity levels in the surrounding areas. Multivariate statistical analyses enabled us to characterise the microclimate of the archaeological site, allowing future testing to determine whether the conservation conditions have been altered. PMID:23899937

Performance analysis of the lineal model for estimating the maximum power of a HCPV module in different climate conditions

NASA Astrophysics Data System (ADS)

Fernández, Eduardo F.; Almonacid, Florencia; Sarmah, Nabin; Mallick, Tapas; Sanchez, Iñigo; Cuadra, Juan M.; Soria-Moya, Alberto; Pérez-Higueras, Pedro

2014-09-01

A model based on easily obtained atmospheric parameters and on a simple lineal mathematical expression has been developed at the Centre of Advanced Studies in Energy and Environment in southern Spain. The model predicts the maximum power of a HCPV module as a function of direct normal irradiance, air temperature and air mass. Presently, the proposed model has only been validated in southern Spain and its performance in locations with different atmospheric conditions still remains unknown. In order to address this issue, several HCPV modules have been measured in two different locations with different climate conditions than the south of Spain: the Environment and Sustainability Institute in southern UK and the National Renewable Energy Center in northern Spain. Results show that the model has an adequate match between actual and estimated data with a RMSE lower than 3.9% at locations with different climate conditions.

Detection of underground pipeline based on Golay waveform design

NASA Astrophysics Data System (ADS)

Dai, Jingjing; Xu, Dazhuan

2017-08-01

The detection of underground pipeline is an important problem in the development of the city, but the research about it is not mature at present. In this paper, based on the principle of waveform design in wireless communication, we design an acoustic signal detection system to detect the location of underground pipelines. According to the principle of acoustic localization, we chose DSP-F28335 as the development board, and use DA and AD module as the master control chip. The DA module uses complementary Golay sequence as emission signal. The AD module acquisiting data synchronously, so that the echo signals which containing position information of the target is recovered through the signal processing. The test result shows that the method in this paper can not only calculate the sound velocity of the soil, but also can locate the location of underground pipelines accurately.

STS-98 Onboard Photograph-U.S. Laboratory, Destiny

NASA Technical Reports Server (NTRS)

2001-01-01

The International Space Station (ISS), with the newly installed U.S. Laboratory, Destiny, is backdropped over clouds, water and land in South America. South Central Chile shows up at the bottom of the photograph. Just below the Destiny, the Chacao Charnel separates the large island of Chile from the mainland and connects the Gulf of Coronado on the Pacific side with the Gulf of Ancud, southwest of the city of Puerto Montt. The American-made Destiny module is the cornerstone for space-based research aboard the orbiting platform and the centerpiece of the ISS, where unprecedented science experiments will be performed in the near-zero gravity of space. Destiny will also serve as the command and control center for the ISS. The aluminum module is 8.5-meters (28-feet) long and 4.3-meters (14-feet) in diameter. The laboratory consists of three cylindrical sections and two endcones with hatches that will be mated to other station components. A 50.9-centimeter (20-inch-) diameter window is located on one side of the center module segment. This pressurized module is designed to accommodate pressurized payloads. It has a capacity of 24 rack locations. Payload racks will occupy 15 locations especially designed to support experiments. The Destiny module was built by the Boeing Company under the direction of the Marshall Space Flight Center.

International Space Station (ISS)

NASA Image and Video Library

2001-02-16

The International Space Station (ISS), with the newly installed U.S. Laboratory, Destiny, is backdropped over clouds, water and land in South America. South Central Chile shows up at the bottom of the photograph. Just below the Destiny, the Chacao Charnel separates the large island of Chile from the mainland and connects the Gulf of Coronado on the Pacific side with the Gulf of Ancud, southwest of the city of Puerto Montt. The American-made Destiny module is the cornerstone for space-based research aboard the orbiting platform and the centerpiece of the ISS, where unprecedented science experiments will be performed in the near-zero gravity of space. Destiny will also serve as the command and control center for the ISS. The aluminum module is 8.5-meters (28-feet) long and 4.3-meters (14-feet) in diameter. The laboratory consists of three cylindrical sections and two endcones with hatches that will be mated to other station components. A 50.9-centimeter (20-inch-) diameter window is located on one side of the center module segment. This pressurized module is designed to accommodate pressurized payloads. It has a capacity of 24 rack locations. Payload racks will occupy 15 locations especially designed to support experiments. The Destiny module was built by the Boeing Company under the direction of the Marshall Space Flight Center.

Understanding the relationship between schizotypy and attention: dissociating stimulus- and dimension-specific processes.

PubMed

Schmidt-Hansen, Mia; Honey, Robert C

2014-03-01

Two experiments investigated how the schizotypal characteristics of unusual experiences modulate changes in attention to alphanumeric stimuli. In the first stage of both experiments, participants were required to attend and respond to either Arabic numerals or Latin letters; with the four exemplars from each dimension being presented on a different number of occasions (0, 5, 10, 20). During the test in Experiment 1 (n=103), speeded alphanumeric decisions were more accurate for the novel than familiar exemplars, irrespective of whether they had been attended to or not. This influence of familiarity was not modulated by schizotypy. During the test in Experiment 2 (n=128), learning that the attended dimension predicted the presentation of the symbol X (or the absence of X) proceeded more rapidly than learning the corresponding predictions involving the unattended dimension. In the case of novel exemplars, but not familiar exemplars, this modulation of learning by attention was reduced as schizotypy scores increased. Taken together, these results show that schizotypal characteristics do not modulate the influence of familiarity on performance (Experiment 1), but do have an influence on attention, which is best characterised as one on tuning attention to stimulus dimensions rather than individual stimuli. Crown Copyright © 2013. Published by Elsevier B.V. All rights reserved.

Logarithmic M(2,p) minimal models, their logarithmic couplings, and duality

NASA Astrophysics Data System (ADS)

Mathieu, Pierre; Ridout, David

2008-10-01

A natural construction of the logarithmic extension of the M(2,p) (chiral) minimal models is presented, which generalises our previous model of percolation ( p=3). Its key aspect is the replacement of the minimal model irreducible modules by reducible ones obtained by requiring that only one of the two principal singular vectors of each module vanish. The resulting theory is then constructed systematically by repeatedly fusing these building block representations. This generates indecomposable representations of the type which signify the presence of logarithmic partner fields in the theory. The basic data characterising these indecomposable modules, the logarithmic couplings, are computed for many special cases and given a new structural interpretation. Quite remarkably, a number of them are presented in closed analytic form (for general p). These are the prime examples of "gauge-invariant" data—quantities independent of the ambiguities present in defining the logarithmic partner fields. Finally, mere global conformal invariance is shown to enforce strong constraints on the allowed spectrum: It is not possible to include modules other than those generated by the fusion of the model's building blocks. This generalises the statement that there cannot exist two effective central charges in a c=0 model. It also suggests the existence of a second "dual" logarithmic theory for each p. Such dual models are briefly discussed.

Inter-annual precipitation variabiity inferred from late Holocene speleothem records from Fiji: implications for SPCZ localisation and ENSO behaviour

NASA Astrophysics Data System (ADS)

Mattey, D.; Stephens, M.; Hoffmann, D.; Brett, M.

2015-12-01

The modern tropical Fiji climate is characterised by seasonal rainfall controlled by the position of the South Pacific Convergence Zone (SPCZ). Interannual rainfall is strongly modulated on decadal timescales by ENSO with higher rainfall associated with La Nina events. Voli Voli cave near Sigatoga (Viti Levu) is a stream passage that has been monitored since 2009. A U-Th dated laminated speleothem spans a 1500 year interval across the transition from the Medieval Warm Period into the Little Ice Age marked by a fabric change from finely laminated calcite with thin clay layers, to white well-laminated calcite. The older record is characterised by rising δ13C values followed by a rapid decrease in δ13C around 1200 AD. Evidence from cave monitoring shows that cave air CO2 levels are strongly seasonal as a result of greater ventilation by winter trade winds and high resolution δ13C record shows regularly spaced peaks correlated with paired laminae and cycles in P and S which provide annual markers driven by rainfall and seasonal ventilation. δ18O values remain relatively unchanged throughout the record but micromilling at sub-annual resolution reveals systematic cycles in δ18O that span groups of paired laminae with an inferred periodicity of 3-7 years i.e. a similar frequency to modern ENSO. The presence of these sub-decadal cycles in δ18O may be a result of a combination of factors. The amplitude of 2-3‰ would be equivalent to an amount-effect related change in annual precipitation of around 50% but an additional smoothing process, perhaps a result of aquifer storage, is required to attenuate interannual variance in precipitation. The Voli Voli record provides evidence of an underlying climatic change to more frequent La Niña conditions from 1200 AD and may be associated with increased conflict, shifts in settlements and changes in subsistence strategies on the island. Coeval speleothem isotope records from tropical Pacific Islands provide a provide a powerful means of locating the mean position and intensity of the SPCZ and changes in regional coupling of ocean-atmospheric circulation patterns.

Characterisation and novel applications of glass beads as dosimeters in radiotherapy

NASA Astrophysics Data System (ADS)

Jafari, Shakardokht

The intent of external beam radiotherapy is to deliver as high a radiation dose as possible to tumour volume whilst minimizing the dose to surrounding normal tissues. Recent development of techniques such as intensity modulated radiation therapy (IMRT) and stereotactic ablative body radiotherapy (SABR) aim to extend this capability. The main feature of these techniques is to use beams which often contain small fields and very steep dose gradients. These present several dosimetric challenges including loss of charge particle equilibrium (CPE), partial occlusion of the direct-beam source and steep fall-off in dose in the penumbra. Dosimeters which are small in size relative to the radiation field dimensions are recommended for such conditions. The particular glass beads studied herein have several potentially favourable physical characteristics; they are small in size (1 to 3 mm diameter), chemically inert, inexpensive, readily available and reusable. The dosimetric characterisation of glass beads has been obtained by irradiating them in various radiotherapy beams of kilo-voltage and mega-voltage photons, megavoltage electrons, protons and carbon ions. They exhibit minimal fading compared with commercial LiF thermo-luminescent (TL) dosimeters, have high TL light transparency, high sensitivity and a large dynamic dose range that remains linear from 1 cGy to 100 Gy They have also been shown to be independent of dose rate and beam incidence angle, as well as having a low variation in response with energy over a range of megavoltage photon and electron beams. The latter characteristic is of importance, where spectral changes may occur as a function of field size and off axis location and for the use of dosimeters in postal audit situations where each institution may have slightly different quality index (QI) for their respective photon energies thus ensuring that the calibration is still valid. These properties suggest their practical use as TL dosimeters for radiotherapy dosimetry. Investigations have been performed to evaluate the feasibility of using glass beads in treatment plan verification, small field radiation dosimetry and postal dosimetry audit.

Space biology initiative program definition review. Trade study 6: Space Station Freedom/spacelab modules compatibility

NASA Technical Reports Server (NTRS)

Jackson, L. Neal; Crenshaw, John, Sr.; Davidson, William L.; Blacknall, Carolyn; Bilodeau, James W.; Stoval, J. Michael; Sutton, Terry

1989-01-01

The differences in rack requirements for Spacelab, the Shuttle Orbiter, and the United States (U.S.) laboratory module, European Space Agency (ESA) Columbus module, and the Japanese Experiment Module (JEM) of Space Station Freedom are identified. The feasibility of designing standardized mechanical, structural, electrical, data, video, thermal, and fluid interfaces to allow space flight hardware designed for use in the U.S. laboratory module to be used in other locations is assessed.

Is that a belt or a snake? object attentional selection affects the early stages of visual sensory processing

PubMed Central

2012-01-01

Background There is at present crescent empirical evidence deriving from different lines of ERPs research that, unlike previously observed, the earliest sensory visual response, known as C1 component or P/N80, generated within the striate cortex, might be modulated by selective attention to visual stimulus features. Up to now, evidence of this modulation has been related to space location, and simple features such as spatial frequency, luminance, and texture. Additionally, neurophysiological conditions, such as emotion, vigilance, the reflexive or voluntary nature of input attentional selection, and workload have also been related to C1 modulations, although at least the workload status has received controversial indications. No information is instead available, at present, for objects attentional selection. Methods In this study object- and space-based attention mechanisms were conjointly investigated by presenting complex, familiar shapes of artefacts and animals, intermixed with distracters, in different tasks requiring the selection of a relevant target-category within a relevant spatial location, while ignoring the other shape categories within this location, and, overall, all the categories at an irrelevant location. EEG was recorded from 30 scalp electrode sites in 21 right-handed participants. Results and Conclusions ERP findings showed that visual processing was modulated by both shape- and location-relevance per se, beginning separately at the latency of the early phase of a precocious negativity (60-80 ms) at mesial scalp sites consistent with the C1 component, and a positivity at more lateral sites. The data also showed that the attentional modulation progressed conjointly at the latency of the subsequent P1 (100-120 ms) and N1 (120-180 ms), as well as later-latency components. These findings support the views that (1) V1 may be precociously modulated by direct top-down influences, and participates to object, besides simple features, attentional selection; (2) object spatial and non-spatial features selection might begin with an early, parallel detection of a target object in the visual field, followed by the progressive focusing of spatial attention onto the location of an actual target for its identification, somehow in line with neural mechanisms reported in the literature as "object-based space selection", or with those proposed for visual search. PMID:22300540

Optimization and performance of bifacial solar modules: A global perspective

DOE PAGES

Sun, Xingshu; Khan, Mohammad Ryyan; Deline, Chris; ...

2018-02-06

With the rapidly growing interest in bifacial photovoltaics (PV), a worldwide map of their potential performance can help assess and accelerate the global deployment of this emerging technology. However, the existing literature only highlights optimized bifacial PV for a few geographic locations or develops worldwide performance maps for very specific configurations, such as the vertical installation. It is still difficult to translate these location- and configuration-specific conclusions to a general optimized performance of this technology. In this paper, we present a global study and optimization of bifacial solar modules using a rigorous and comprehensive modeling framework. Our results demonstrate thatmore » with a low albedo of 0.25, the bifacial gain of ground-mounted bifacial modules is less than 10% worldwide. However, increasing the albedo to 0.5 and elevating modules 1 m above the ground can boost the bifacial gain to 30%. Moreover, we derive a set of empirical design rules, which optimize bifacial solar modules across the world and provide the groundwork for rapid assessment of the location-specific performance. We find that ground-mounted, vertical, east-west-facing bifacial modules will outperform their south-north-facing, optimally tilted counterparts by up to 15% below the latitude of 30 degrees, for an albedo of 0.5. The relative energy output is reversed in latitudes above 30 degrees. A detailed and systematic comparison with data from Asia, Africa, Europe, and North America validates the model presented in this paper.« less

Optimization and performance of bifacial solar modules: A global perspective

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sun, Xingshu; Khan, Mohammad Ryyan; Deline, Chris

With the rapidly growing interest in bifacial photovoltaics (PV), a worldwide map of their potential performance can help assess and accelerate the global deployment of this emerging technology. However, the existing literature only highlights optimized bifacial PV for a few geographic locations or develops worldwide performance maps for very specific configurations, such as the vertical installation. It is still difficult to translate these location- and configuration-specific conclusions to a general optimized performance of this technology. In this paper, we present a global study and optimization of bifacial solar modules using a rigorous and comprehensive modeling framework. Our results demonstrate thatmore » with a low albedo of 0.25, the bifacial gain of ground-mounted bifacial modules is less than 10% worldwide. However, increasing the albedo to 0.5 and elevating modules 1 m above the ground can boost the bifacial gain to 30%. Moreover, we derive a set of empirical design rules, which optimize bifacial solar modules across the world and provide the groundwork for rapid assessment of the location-specific performance. We find that ground-mounted, vertical, east-west-facing bifacial modules will outperform their south-north-facing, optimally tilted counterparts by up to 15% below the latitude of 30 degrees, for an albedo of 0.5. The relative energy output is reversed in latitudes above 30 degrees. A detailed and systematic comparison with data from Asia, Africa, Europe, and North America validates the model presented in this paper.« less

Health Instruction Packages: Dental Personnel.

ERIC Educational Resources Information Center

Hayes, Gary E.; And Others

Text, illustrations, and exercises are utilized in this set of four learning modules designed to instruct non-professional dental personnel in selected job-related skills. The first module, by Gary E. Hayes, describes how to locate the hinge axis point of the jaw, place and secure a bitefork, and perform a facebow transfer. The second module,…

Nuclear Technology. Course 27: Metrology. Module 27-5, Tolerancing.

ERIC Educational Resources Information Center

Selleck, Ben; Espy, John

This fifth in a series of eight modules for a course titled Metrology describes the application of the American National Standard (ANSI Y14.5-1973) for dimensioning and tolerancing and gives guidance on interpreting form and location controls consistent with the national standard. The module follows a typical format that includes the following…

Small Business Management. Going-Into-Business Modules for Adult and/or Post Secondary Instruction.

ERIC Educational Resources Information Center

Rice, Fred; And Others

Fifteen modules on small business management are provided in this curriculum guide developed for postsecondary vocational instructors. Module titles are as follow: decision making steps; financing a small business; location of a small business; record systems; the balance sheet and profit and loss statement; purchasing; marketing; sales; cash…

Characterisation of adipocyte-derived extracellular vesicle subtypes identifies distinct protein and lipid signatures for large and small extracellular vesicles

PubMed Central

Durcin, Maëva; Fleury, Audrey; Taillebois, Emiliane; Hilairet, Grégory; Krupova, Zuzana; Henry, Céline; Truchet, Sandrine; Trötzmüller, Martin; Köfeler, Harald; Mabilleau, Guillaume; Hue, Olivier; Andriantsitohaina, Ramaroson; Martin, Patrice; Le Lay, Soazig

2017-01-01

ABSTRACT Extracellular vesicles (EVs) are biological vectors that can modulate the metabolism of target cells by conveying signalling proteins and genomic material. The level of EVs in plasma is significantly increased in cardiometabolic diseases associated with obesity, suggesting their possible participation in the development of metabolic dysfunction. With regard to the poor definition of adipocyte-derived EVs, the purpose of this study was to characterise both qualitatively and quantitatively EVs subpopulations secreted by fat cells. Adipocyte-derived EVs were isolated by differential centrifugation of conditioned media collected from 3T3-L1 adipocytes cultured for 24 h in serum-free conditions. Based on morphological and biochemical properties, as well as quantification of secreted EVs, we distinguished two subpopulations of adipocyte-derived EVs, namely small extracellular vesicles (sEVs) and large extracellular vesicles (lEVs). Proteomic analyses revealed that lEVs and sEVs exhibit specific protein signatures, allowing us not only to define novel markers of each population, but also to predict their biological functions. Despite similar phospholipid patterns, the comparative lipidomic analysis performed on these EV subclasses revealed a specific cholesterol enrichment of the sEV population, whereas lEVs were characterised by high amounts of externalised phosphatidylserine. Enhanced secretion of lEVs and sEVs is achievable following exposure to different biological stimuli related to the chronic low-grade inflammation state associated with obesity. Finally, we demonstrate the ability of primary murine adipocytes to secrete sEVs and lEVs, which display physical and biological characteristics similar to those described for 3T3-L1. Our study provides additional information and elements to define EV subtypes based on the characterisation of adipocyte-derived EV populations. It also underscores the need to distinguish EV subpopulations, through a combination of multiple approaches and markers, since their specific composition may cause distinct metabolic responses in recipient cells and tissues. PMID:28473884

View of damaged Apollo 13 Service Module from the Lunar/Command Modules

NASA Image and Video Library

1970-04-17

AS13-58-8464 (17 April 1970) --- This view of the severely damaged Apollo 13 Service Module (SM) was photographed from the Lunar Module/Command Module (LM/CM) following SM jettisoning. Nearest the camera is the Service Propulsion System (SPS) engine and nozzle. An entire SM panel was blown away by the apparent explosion of oxygen tank number two located in Sector 4 of the SM. The apparent rupture of the oxygen tank caused the Apollo 13 crew men to use the Lunar Module (LM) as a "lifeboat".

Determination of Flaw Type and Location Using an Expert Module in Ultrasonic Nondestructive Testing for Weld Inspection

NASA Astrophysics Data System (ADS)

Shahriari, D.; Zolfaghari, A.; Masoumi, F.

2011-01-01

Nondestructive evaluation is explained as nondestructive testing, nondestructive inspection, and nondestructive examination. It is a desire to determine some characteristic of the object or to determine whether the object contains irregularities, discontinuities, or flaws. Ultrasound based inspection techniques are used extensively throughout industry for detection of flaws in engineering materials. The range and variety of imperfections encountered is large, and critical assessment of location, size, orientation and type is often difficult. In addition, increasing quality requirements of new standards and codes of practice relating to fitness for purpose are placing higher demands on operators. Applying of an expert knowledge-based analysis in ultrasonic examination is a powerful tool that can help assure safety, quality, and reliability; increase productivity; decrease liability; and save money. In this research, an expert module system is coupled with ultrasonic examination (A-Scan Procedure) to determine and evaluate type and location of flaws that embedded during welding parts. The processing module of this expert system is implemented based on EN standard to classify welding defects, acceptance condition and measuring of their location via echo static pattern and image processing. The designed module introduces new system that can automate evaluating of the results of A-scan method according to EN standard. It can simultaneously recognize the number and type of defects, and determine flaw position during each scan.

Biochemical and biomechanical characterisation of equine cervical facet joint cartilage.

PubMed

O'Leary, S A; White, J L; Hu, J C; Athanasiou, K A

2018-04-15

The equine cervical facet joint is a site of significant pathology. Located bilaterally on the dorsal spine, these diarthrodial joints work in conjunction with the intervertebral disc to facilitate appropriate spinal motion. Despite the high prevalence of pathology in this joint, the facet joint is understudied and thus lacking in viable treatment options. The goal of this study was to characterise equine facet joint cartilage and provide a comprehensive database describing the morphological, histological, biochemical and biomechanical properties of this tissue. Descriptive cadaver studies. A total of 132 facet joint surfaces were harvested from the cervical spines of six skeletally mature horses (11 surfaces per animal) for compiling biomechanical and biochemical properties of hyaline cartilage of the equine cervical facet joints. Gross morphometric measurements and histological staining were performed on facet joint cartilage. Creep indentation and uniaxial strain-to-failure testing were used to determine the biomechanical compressive and tensile properties. Biochemical assays included quantification of total collagen, sulfated glycosaminoglycan and DNA content. The facet joint surfaces were ovoid in shape with a flat articular surface. Histological analyses highlighted structures akin to articular cartilage of other synovial joints. In general, biomechanical and biochemical properties did not differ significantly between the inferior and superior joint surfaces as well as among spinal levels. Interestingly, compressive and tensile properties of cervical facet articular cartilage were lower than those of articular cartilage from other previously characterised equine joints. Removal of the superficial zone reduced the tissue's tensile strength, suggesting that this zone is important for the tensile integrity of the tissue. Facet surfaces were sampled at a single, central location and do not capture the potential topographic variation in cartilage properties. This is the first study to report the properties of equine cervical facet joint cartilage and may serve as the foundation for the development of future tissue-engineered replacements as well as other treatment strategies. © 2018 EVJ Ltd.

Identification and characterisation of local aerosol sources using high temporal resolution measurements.

PubMed

Contini, D; Donateo, A; Cesari, D; Belosi, F; Francioso, S

2010-09-01

Aerosol and gaseous pollution measurements were carried out at an urban background site in the south of Italy located near an industrial complex. Collection of 24 h samples of PM10 and PM2.5 and successive chemical quantification of metals were performed. Data were compared with measurements taken at a suburban background site, located at 25 km distance. The comparison showed the presence of an industrial contribution with a well defined chemical emission profile, similar, in terms of metals content, to urban emissions. As this made difficult the quantitative characterisation of the contribution of the two sources to atmospheric PM, a statistical method based on the treatment of data arising from high temporal resolution measurements was developed. Data were taken with a micrometeorological station based on an integrating nephelometer (Mie pDR-1200) for optical detection of PM2.5 concentration, with successive evaluation of vertical turbulent fluxes using the eddy-correlation method. Results show that the contribution from the two sources (urban emissions and industrial releases) have a very different behaviour, with the industrial contribution being present at high wind velocity with short concentration peaks (average duration 4 min) associated to strong positive and negative vertical fluxes. The estimated contribution to PM2.5 is 2.3% over long-term averages. The urban emissions are mainly present at low wind velocity, with longer concentration peaks in the morning and late evening hours, generally associated to small positive vertical fluxes. The characterisation of the contribution was performed using deposition velocity V(d) that is on average -3.5 mm s(-1) and has a diurnal pattern, with negligible values during the night and a minimum value of around -9 mm s(-1) late in the afternoon. Results show a correlation between V(d), friction velocity and wind velocity that could be the basis for a parameterisation of V(d) to be used in dispersion codes.

On-site characterisation, re-packaging and transport of luminised, former aircraft escape hatches

DOE Office of Scientific and Technical Information (OSTI.GOV)

Reeves, Nigel; John, Gordon; Beadle, Ian

2007-07-01

AMEC NNC, under contract to the UK Environment Agency, recovered a number of redundant aircraft hatches from an insecure location in North Wales. The Environment Agency instigated emergency action under the Radioactive Substances Act 1993 (RSA93), to recover the hatches. Section 30(1) of RSA93 gives the Environment Agency powers to dispose of radioactive waste where it is unlikely the waste will be lawfully disposed of. Funding for this project was provided by the UK Government, within the Surplus Source Disposal Programme. The Environment Agency worked closely with partner regulatory organisations including the Health and Safety Executive (HSE), the Department formore » Transport (DfT) and the Local Authority to ensure the safe packaging, removal and transport of the material to a part-shielded store pending final disposal. The project comprised a number of technical difficulties that needed to be overcome. These included poor existing characterisation of the waste, insecure premises requiring daily lock-down, construction of a temporary containment facility with associated filtered extract and the inclement weather. AMEC NNC's initial risk assessment identified the likelihood of high levels of loose, airborne radiological material. In order to provide adequate protection for personnel, and to prevent the spread of any radioactive contamination, the decision was made to implement radiological containment and to equip contractors with appropriate RPE (Respiratory Protective Equipment). Accurate characterisation of the radiological nature of the material was a crucial objective within the project. This was in order to correctly identify the Proper Shipping Name for consignment for transport, and to ensure that suitable transport containers were used. The packaged wastes were then transported to a secure location for temporary storage prior to final disposal. An innovative route was identified for processing of this material. Beneficial recycling and re-use within the nuclear industry was the outcome. (authors)« less

Auditory-visual integration modulates location-specific repetition suppression of auditory responses.

PubMed

Shrem, Talia; Murray, Micah M; Deouell, Leon Y

2017-11-01

Space is a dimension shared by different modalities, but at what stage spatial encoding is affected by multisensory processes is unclear. Early studies observed attenuation of N1/P2 auditory evoked responses following repetition of sounds from the same location. Here, we asked whether this effect is modulated by audiovisual interactions. In two experiments, using a repetition-suppression paradigm, we presented pairs of tones in free field, where the test stimulus was a tone presented at a fixed lateral location. Experiment 1 established a neural index of auditory spatial sensitivity, by comparing the degree of attenuation of the response to test stimuli when they were preceded by an adapter sound at the same location versus 30° or 60° away. We found that the degree of attenuation at the P2 latency was inversely related to the spatial distance between the test stimulus and the adapter stimulus. In Experiment 2, the adapter stimulus was a tone presented from the same location or a more medial location than the test stimulus. The adapter stimulus was accompanied by a simultaneous flash displayed orthogonally from one of the two locations. Sound-flash incongruence reduced accuracy in a same-different location discrimination task (i.e., the ventriloquism effect) and reduced the location-specific repetition-suppression at the P2 latency. Importantly, this multisensory effect included topographic modulations, indicative of changes in the relative contribution of underlying sources across conditions. Our findings suggest that the auditory response at the P2 latency is affected by spatially selective brain activity, which is affected crossmodally by visual information. © 2017 Society for Psychophysiological Research.

Predictors of adherence among community users of a cognitive behavior therapy website

PubMed Central

Batterham, Philip J; Neil, Alison L; Bennett, Kylie; Griffiths, Kathleen M; Christensen, Helen

2008-01-01

Objective To investigate the predictors of early and late dropout among community users of the MoodGYM website, a five module online intervention for reducing the symptoms of depression. Method Approximately 82,000 users accessed the site in 2006, of which 27% completed one module and 10% completed two or more modules. Adherence was modeled as a trichotomous variable representing non-starters (0 modules), early dropouts (1 module) and late dropouts (2–5 modules). Predictor variables included age, gender, education, location, referral source, depression severity, anxiety severity, dysfunctional thinking, and change in symptom count. Results Better adherence was predicted by higher depression severity, higher anxiety severity, a greater level of dysfunctional thinking, younger age, higher education, being female, and being referred to the site by a mental health professional. In addition, users whose depression severity had improved or remained stable after the first intervention module had higher odds of completing subsequent modules. Conclusions While the effect of age and the null effect of location were in accordance with prior adherence research, the significant effects of gender, education and depression severity were not, and may reflect user characteristics, the content of the intervention and unique aspects of online interventions. Further research directions are suggested to investigate the elements of open access online interventions that facilitate adherence. PMID:19920949

Attention operates uniformly throughout the classical receptive field and the surround

PubMed Central

Verhoef, Bram-Ernst; Maunsell, John HR

2016-01-01

Shifting attention among visual stimuli at different locations modulates neuronal responses in heterogeneous ways, depending on where those stimuli lie within the receptive fields of neurons. Yet how attention interacts with the receptive-field structure of cortical neurons remains unclear. We measured neuronal responses in area V4 while monkeys shifted their attention among stimuli placed in different locations within and around neuronal receptive fields. We found that attention interacts uniformly with the spatially-varying excitation and suppression associated with the receptive field. This interaction explained the large variability in attention modulation across neurons, and a non-additive relationship among stimulus selectivity, stimulus-induced suppression and attention modulation that has not been previously described. A spatially-tuned normalization model precisely accounted for all observed attention modulations and for the spatial summation properties of neurons. These results provide a unified account of spatial summation and attention-related modulation across both the classical receptive field and the surround. DOI: http://dx.doi.org/10.7554/eLife.17256.001 PMID:27547989

Neural activity reveals perceptual grouping in working memory.

PubMed

Rabbitt, Laura R; Roberts, Daniel M; McDonald, Craig G; Peterson, Matthew S

2017-03-01

There is extensive evidence that the contralateral delay activity (CDA), a scalp recorded event-related brain potential, provides a reliable index of the number of objects held in visual working memory. Here we present evidence that the CDA not only indexes visual object working memory, but also the number of locations held in spatial working memory. In addition, we demonstrate that the CDA can be predictably modulated by the type of encoding strategy employed. When individual locations were held in working memory, the pattern of CDA modulation mimicked previous findings for visual object working memory. Specifically, CDA amplitude increased monotonically until working memory capacity was reached. However, when participants were instructed to group individual locations to form a constellation, the CDA was prolonged and reached an asymptote at two locations. This result provides neural evidence for the formation of a unitary representation of multiple spatial locations. Published by Elsevier B.V.

Using PVDF to locate the debris cloud impact position

NASA Astrophysics Data System (ADS)

Pang, Baojun; Liu, Zhidong

2010-03-01

With the increase of space activities, space debris environment has deteriorated. Space debris impact shields of spacecraft creates debris cloud, the debris cloud is a threat to module wall. In order to conduct an assessment of spacecraft module wall damage impacted by debris cloud, the damage position must be known. In order to design a light weight location system, polyvinylidene fluoride (PVDF) has been studied. Hyper-velocity impact experiments were conducted using two-stage light gas gun, the experimental results indicate that: the virtual wave front location method can be extended to debris cloud impact location, PVDF can be used to locate the damage position effectively, the signals gathered by PVDF from debris cloud impact contain more high frequency components than the signals created by single projectile impact event. The results provide a reference for the development of the sensor systems to detect impacts on spacecraft.

Sedimentology and sequence stratigraphy from outcrops of the Kribi-Campo sub-basin: Lower Mundeck Formation (Lower Cretaceous, southern Cameroon)

NASA Astrophysics Data System (ADS)

Ntamak-Nida, Marie Joseph; Bourquin, Sylvie; Makong, Jean-Claude; Baudin, François; Mpesse, Jean Engelbert; Ngouem, Christophe Itjoko; Komguem, Paul Bertrand; Abolo, Guy Martin

2010-08-01

The Kribi-Campo sub-basin is composed of an Early to Mid Cretaceous series from West Africa's Atlantic coast and is located in southern Cameroon in the Central African equatorial rain forest. It is the smallest coastal basin in Cameroon and forms the southern part of the Douala/Kribi-Campo basin known as Douala basin ( s.l.). Until now, no detailed sedimentological studies have been carried out on the outcrops of this basin located in the Campo area. The aim of this study was to characterise the depositional environments, vertical evolution and tectonic context of these Lower Cretaceous series in order to make a comparison with adjacent basins and replace them in the geodynamic context. Facies analysis of the Lower Mundeck Formation (Lower Cretaceous) indicates the presence of four major, interfigered facies associations, that are inferred to represent elements of an alluvial to lacustrine-fan delta system. The clast lithologies suggest proximity of relief supplying coarse-grained sediment during the deposition of the Lower Mundeck Formation at Campo. The general dip and direction of the bedding is approximately 10°-12°NW, which also corresponds to the orientation of the foliations in the underlying metamorphic basement. The main sedimentary succession is characterised by a major retrogradational/progradational cycle of Late Aptian age, evaluated at about 3 Ma, with a well-developed progradational trend characterised by fluctuations of the recognised depositional environments. Fluctuations in lake level and sediment supply were possibly controlled by active faults at the basin margin, although climatic changes may have also played a role. The consistently W-WNW palaeoflow of sediments suggests that the palaeorelief was located to the east and could be oriented in a NNE-SSW direction, downthrown to the west. Local outcrops dated as Albian, both north and south of the main outcrop, display some marine influence. These deposits are cut by 040-060 faults parallel to the oceanic transform. Similarly, the Lower Mundeck Formation of the Campo outcrops is considered to be associated mainly with the early drift period of Late Aptian-Albian age. This study is also the first step of knowledge of these African margin deposits, to realise in the future the correlations between outcrops and offshore data.

Scalable Hierarchical Network Management System for Displaying Network Information in Three Dimensions

NASA Technical Reports Server (NTRS)

George, Jude (Inventor); Schlecht, Leslie (Inventor); McCabe, James D. (Inventor); LeKashman, John Jr. (Inventor)

1998-01-01

A network management system has SNMP agents distributed at one or more sites, an input output module at each site, and a server module located at a selected site for communicating with input output modules, each of which is configured for both SNMP and HNMP communications. The server module is configured exclusively for HNMP communications, and it communicates with each input output module according to the HNMP. Non-iconified, informationally complete views are provided of network elements to aid in network management.

Method and apparatus for determining the coordinates of an object

DOEpatents

Pedersen, Paul S; Sebring, Robert

2003-01-01

A method and apparatus is described for determining the coordinates on the surface of an object which is illuminated by a beam having pixels which have been modulated according to predetermined mathematical relationships with pixel position within the modulator. The reflected illumination is registered by an image sensor at a known location which registers the intensity of the pixels as received. Computations on the intensity, which relate the pixel intensities received to the pixel intensities transmitted at the modulator, yield the proportional loss of intensity and planar position of the originating pixels. The proportional loss and position information can then be utilized within triangulation equations to resolve the coordinates of associated surface locations on the object.

Attention Effects on Neural Population Representations for Shape and Location Are Stronger in the Ventral than Dorsal Stream

PubMed Central

2018-01-01

Abstract We examined how attention causes neural population representations of shape and location to change in ventral stream (AIT) and dorsal stream (LIP). Monkeys performed two identical delayed-match-to-sample (DMTS) tasks, attending either to shape or location. In AIT, shapes were more discriminable when directing attention to shape rather than location, measured by an increase in mean distance between population response vectors. In LIP, attending to location rather than shape did not increase the discriminability of different stimulus locations. Even when factoring out the change in mean vector response distance, multidimensional scaling (MDS) still showed a significant task difference in AIT, but not LIP, indicating that beyond increasing discriminability, attention also causes a nonlinear warping of representation space in AIT. Despite single-cell attentional modulations in both areas, our data show that attentional modulations of population representations are weaker in LIP, likely due to a need to maintain veridical representations for visuomotor control. PMID:29876521

Genomic characterisation of Wongabel virus reveals novel genes within the Rhabdoviridae.

PubMed

Gubala, Aneta J; Proll, David F; Barnard, Ross T; Cowled, Chris J; Crameri, Sandra G; Hyatt, Alex D; Boyle, David B

2008-06-20

Viruses belonging to the family Rhabdoviridae infect a variety of different hosts, including insects, vertebrates and plants. Currently, there are approximately 200 ICTV-recognised rhabdoviruses isolated around the world. However, the majority remain poorly characterised and only a fraction have been definitively assigned to genera. The genomic and transcriptional complexity displayed by several of the characterised rhabdoviruses indicates large diversity and complexity within this family. To enable an improved taxonomic understanding of this family, it is necessary to gain further information about the poorly characterised members of this family. Here we present the complete genome sequence and predicted transcription strategy of Wongabel virus (WONV), a previously uncharacterised rhabdovirus isolated from biting midges (Culicoides austropalpalis) collected in northern Queensland, Australia. The 13,196 nucleotide genome of WONV encodes five typical rhabdovirus genes N, P, M, G and L. In addition, the WONV genome contains three genes located between the P and M genes (U1, U2, U3) and two open reading frames overlapping with the N and G genes (U4, U5). These five additional genes and their putative protein products appear to be novel, and their functions are unknown. Predictive analysis of the U5 gene product revealed characteristics typical of viroporins, and indicated structural similarities with the alpha-1 protein (putative viroporin) of viruses in the genus Ephemerovirus. Phylogenetic analyses of the N and G proteins of WONV indicated closest similarity with the avian-associated Flanders virus; however, the genomes of these two viruses are significantly diverged. WONV displays a novel and unique genome structure that has not previously been described for any animal rhabdovirus.

Characterising alluvial aquifers in a remote ephemeral catchment (Flinders River, Queensland) using a direct push tracer approach

NASA Astrophysics Data System (ADS)

Taylor, Andrew R.; Smith, Stanley D.; Lamontagne, Sébastien; Suckow, Axel

2018-01-01

The availability of reliable water supplies is a key factor limiting development in northern Australia. However, characterising groundwater resources in this remote part of Australia is challenging due to a lack of existing infrastructure and data. Here, direct push technology (DPT) was used to characterise shallow alluvial aquifers at two locations in the semiarid Flinders River catchment. DPT was used to evaluate the saturated thickness of the aquifer and estimate recharge rates by sampling for environmental tracers in groundwater (major ions, 2H, 18O, 3H and 14C). The alluvium at Fifteen Mile Reserve and Glendalough Station consisted of a mixture of permeable coarse sandy and gravely sediments and less permeable clays and silts. The alluvium was relatively thin (i.e. < 20 m) and, at the time of the investigation, was only partially saturated. Tritium (3H) concentrations in groundwater was ∼1 Tritium Unit (TU), corresponding to a mean residence time for groundwater of about 12 years. The lack of an evaporation signal for the 2H and 18O of groundwater suggests rapid localised recharge from overbank flood events as the primary recharge mechanism. Using the chloride mass balance technique (CMB) and lumped parameter models to interpret patterns in 3H in the aquifer, the mean annual recharge rate varied between 21 and 240 mm/yr. Whilst this recharge rate is relatively high for a semiarid climate, the alluvium is thin and heterogeneous hosting numerous alluvial aquifers with varied connectivity and limited storage capacity. Combining DPT and environmental tracers is a cost-effective strategy to characterise shallow groundwater resources in unconsolidated sedimentary aquifers in remote data sparse areas.

The design and performance of a scintillating-fibre tracker for the cosmic-ray muon tomography of legacy nuclear waste containers

NASA Astrophysics Data System (ADS)

Clarkson, A.; Hamilton, D. J.; Hoek, M.; Ireland, D. G.; Johnstone, J. R.; Kaiser, R.; Keri, T.; Lumsden, S.; Mahon, D. F.; McKinnon, B.; Murray, M.; Nutbeam-Tuffs, S.; Shearer, C.; Staines, C.; Yang, G.; Zimmerman, C.

2014-05-01

Tomographic imaging techniques using the Coulomb scattering of cosmic-ray muons are increasingly being exploited for the non-destructive assay of shielded containers in a wide range of applications. One such application is the characterisation of legacy nuclear waste materials stored within industrial containers. The design, assembly and performance of a prototype muon tomography system developed for this purpose are detailed in this work. This muon tracker comprises four detection modules, each containing orthogonal layers of Saint-Gobain BCF-10 2 mm-pitch plastic scintillating fibres. Identification of the two struck fibres per module allows the reconstruction of a space point, and subsequently, the incoming and Coulomb-scattered muon trajectories. These allow the container content, with respect to the atomic number Z of the scattering material, to be determined through reconstruction of the scattering location and magnitude. On each detection layer, the light emitted by the fibre is detected by a single Hamamatsu H8500 MAPMT with two fibres coupled to each pixel via dedicated pairing schemes developed to ensure the identification of the struck fibre. The PMT signals are read out to standard charge-to-digital converters and interpreted via custom data acquisition and analysis software. The design and assembly of the detector system are detailed and presented alongside results from performance studies with data collected after construction. These results reveal high stability during extended collection periods with detection efficiencies in the region of 80% per layer. Minor misalignments of millimetre order have been identified and corrected in software. A first image reconstructed from a test configuration of materials has been obtained using software based on the Maximum Likelihood Expectation Maximisation algorithm. The results highlight the high spatial resolution provided by the detector system. Clear discrimination between the low, medium and high-Z materials assayed is also observed.

STS-96 crew takes part in payload Interface Verification Test

NASA Technical Reports Server (NTRS)

1999-01-01

Posing on the platform next to the SPACEHAB Logistics Double Module in the SPACEHAB Facility are the STS-96 crew (from left) Mission Specialists Dan Barry, Tamara Jernigan, Valery Tokarev of Russia, and Julie Payette; Pilot Rick Husband; Mission Specialist Ellen Ochoa; and Commander Kent Rominger. The crew is at KSC for a payload Interface Verification Test for their upcoming mission to the International Space Station. Mission STS-96 carries the SPACEHAB Logistics Double Module, which will have equipment to further outfit the International Space Station service module and equipment that can be off-loaded from the early U.S. assembly flights. It carries internal logistics and resupply cargo for station outfitting, plus an external Russian cargo crane to be mounted to the exterior of the Russian station segment and used to perform space walking maintenance activities. The double module stowage provides capacity of up to 10,000 lbs. with the ability to accommodate powered payloads, four external rooftop stowage locations, four double-rack locations (two powered), up to 61 bulkhead-mounted middeck locker locations, and floor storage for large unique items and Soft Stowage. STS-96 is targeted to launch May 20 about 9:32 a.m.

STS-96 crew takes part in payload Interface Verification Test

NASA Technical Reports Server (NTRS)

1999-01-01

During a payload Interface Verification Test (IVT) for the upcoming mission to the International Space Station , Chris Jaskolka of Boeing points out a piece of equipment in the SPACEHAB module to STS-96 Commander Kent Rominger, Mission Specialist Ellen Ochoa and Pilot Rick Husband. Other crew members visiting KSC for the IVT are Mission Specialists Tamara Jernigan, Dan Barry, Julie Payette and Valery Tokarev of Russia. Mission STS-96 carries the SPACEHAB Logistics Double Module, which will have equipment to further outfit the International Space Station service module and equipment that can be off-loaded from the early U.S. assembly flights. It carries internal logistics and resupply cargo for station outfitting, plus an external Russian cargo crane to be mounted to the exterior of the Russian station segment and used to perform space walking maintenance activities. The double module stowage provides capacity of up to 10,000 lbs. with the ability to accommodate powered payloads, four external rooftop stowage locations, four double-rack locations (two powered), up to 61 bulkhead-mounted middeck locker locations, and floor storage for large unique items and Soft Stowage. STS-96 is targeted to launch May 20 about 9:32 a.m. EDT.

Program structure-based blocking

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bertolli, Carlo; Eichenberger, Alexandre E.; O'Brien, John K.

2017-09-26

Embodiments relate to program structure-based blocking. An aspect includes receiving source code corresponding to a computer program by a compiler of a computer system. Another aspect includes determining a prefetching section in the source code by a marking module of the compiler. Yet another aspect includes performing, by a blocking module of the compiler, blocking of instructions located in the prefetching section into instruction blocks, such that the instruction blocks of the prefetching section only contain instructions that are located in the prefetching section.

Location of Microbial Ecology Evaluation Device in Apollo Command Module

NASA Technical Reports Server (NTRS)

1971-01-01

The location of the Microbial Ecology Evaluation Device (MEED) installed on the open hatch of the Apollo Command Module is illustrated in this photograph. The MEED, equipment of the Microbial Response in Space Environment experiment, will house a selection of microbial systems. The MEED will be deployed during the extravehicular activity on the transearth coast phase of the Aopllo 16 lunar landing mission. The purpose of the experiment will be to measure the effects of certain space environmental parameters on the microbial test systems.

Identification coding schemes for modulated reflectance systems

DOEpatents

Coates, Don M [Santa Fe, NM; Briles, Scott D [Los Alamos, NM; Neagley, Daniel L [Albuquerque, NM; Platts, David [Santa Fe, NM; Clark, David D [Santa Fe, NM

2006-08-22

An identifying coding apparatus employing modulated reflectance technology involving a base station emitting a RF signal, with a tag, located remotely from the base station, and containing at least one antenna and predetermined other passive circuit components, receiving the RF signal and reflecting back to the base station a modulated signal indicative of characteristics related to the tag.

Embedded diagnostic, prognostic, and health management system and method for a humanoid robot

NASA Technical Reports Server (NTRS)

Barajas, Leandro G. (Inventor); Strawser, Philip A (Inventor); Sanders, Adam M (Inventor); Reiland, Matthew J (Inventor)

2013-01-01

A robotic system includes a humanoid robot with multiple compliant joints, each moveable using one or more of the actuators, and having sensors for measuring control and feedback data. A distributed controller controls the joints and other integrated system components over multiple high-speed communication networks. Diagnostic, prognostic, and health management (DPHM) modules are embedded within the robot at the various control levels. Each DPHM module measures, controls, and records DPHM data for the respective control level/connected device in a location that is accessible over the networks or via an external device. A method of controlling the robot includes embedding a plurality of the DPHM modules within multiple control levels of the distributed controller, using the DPHM modules to measure DPHM data within each of the control levels, and recording the DPHM data in a location that is accessible over at least one of the high-speed communication networks.

Modulation of gut microbiota dysbioses in type 2 diabetic patients by macrobiotic Ma-Pi 2 diet.

PubMed

Candela, Marco; Biagi, Elena; Soverini, Matteo; Consolandi, Clarissa; Quercia, Sara; Severgnini, Marco; Peano, Clelia; Turroni, Silvia; Rampelli, Simone; Pozzilli, Paolo; Pianesi, Mario; Fallucca, Francesco; Brigidi, Patrizia

2016-07-01

The gut microbiota exerts a role in type 2 diabetes (T2D), and deviations from a mutualistic ecosystem layout are considered a key environmental factor contributing to the disease. Thus, the possibility of improving metabolic control in T2D by correcting gut microbiome dysbioses through diet has been evaluated. Here, we explore the potential of two different energy-restricted dietary approaches - the fibre-rich macrobiotic Ma-Pi 2 diet or a control diet recommended by Italian professional societies for T2D treatment - to correct gut microbiota dysbioses in T2D patients. In a previous 21-d open-label MADIAB trial, fifty-six overweight T2D patients were randomised to the Ma-Pi 2 or the control diet. For the present study, stools were collected before and after intervention from a subset of forty MADIAB participants, allowing us to characterise the gut microbiota by 16S rRNA sequencing and imputed metagenomics. To highlight microbiota dysbioses in T2D, the gut microbiota of thirteen normal-weight healthy controls were characterised. According to our findings, both diets were effective in modulating gut microbiome dysbioses in T2D, resulting in an increase of the ecosystem diversity and supporting the recovery of a balanced community of health-promoting SCFA producers, such as Faecalibacterium, Roseburia, Lachnospira, Bacteroides and Akkermansia. The Ma-Pi 2 diet, but not the control diet, was also effective in counteracting the increase of possible pro-inflammatory groups, such as Collinsella and Streptococcus, in the gut ecosystem, showing the potential to reverse pro-inflammatory dysbioses in T2D, and possibly explaining the greater efficacy in improving the metabolic control.

Line drawing of layout of Scietific Instrument Module of Apollo 16

NASA Image and Video Library

1972-03-01

A line drawing illustrating the layout of the Scietific Instrument Module (SIM) of the Apollo 16 Service Module. Shown here is the location in the SIM bay of the equipment for each orbital experiment. Arrows point to various components of the SIM bay. The sensors for the gamma ray spectrometer and the mas spectrometer both extend outward on a boom about 25 feet when the instruments are in use. The subsatellite is launched while the Service Module is in orbit around the moon. The film cassettes must be retrieved prior to Command Module/Service Module separation.

Somatosensory nociceptive characteristics differentiate subgroups in people with chronic low back pain: a cluster analysis.

PubMed

Rabey, Martin; Slater, Helen; OʼSullivan, Peter; Beales, Darren; Smith, Anne

2015-10-01

The objectives of this study were to explore the existence of subgroups in a cohort with chronic low back pain (n = 294) based on the results of multimodal sensory testing and profile subgroups on demographic, psychological, lifestyle, and general health factors. Bedside (2-point discrimination, brush, vibration and pinprick perception, temporal summation on repeated monofilament stimulation) and laboratory (mechanical detection threshold, pressure, heat and cold pain thresholds, conditioned pain modulation) sensory testing were examined at wrist and lumbar sites. Data were entered into principal component analysis, and 5 component scores were entered into latent class analysis. Three clusters, with different sensory characteristics, were derived. Cluster 1 (31.9%) was characterised by average to high temperature and pressure pain sensitivity. Cluster 2 (52.0%) was characterised by average to high pressure pain sensitivity. Cluster 3 (16.0%) was characterised by low temperature and pressure pain sensitivity. Temporal summation occurred significantly more frequently in cluster 1. Subgroups were profiled on pain intensity, disability, depression, anxiety, stress, life events, fear avoidance, catastrophizing, perception of the low back region, comorbidities, body mass index, multiple pain sites, sleep, and activity levels. Clusters 1 and 2 had a significantly greater proportion of female participants and higher depression and sleep disturbance scores than cluster 3. The proportion of participants undertaking <300 minutes per week of moderate activity was significantly greater in cluster 1 than in clusters 2 and 3. Low back pain, therefore, does not appear to be homogeneous. Pain mechanisms relating to presentations of each subgroup were postulated. Future research may investigate prognoses and interventions tailored towards these subgroups.

ICRH antenna S-matrix measurements and plasma coupling characterisation at JET

NASA Astrophysics Data System (ADS)

Monakhov, I.; Jacquet, P.; Blackman, T.; Bobkov, V.; Dumortier, P.; Helou, W.; Lerche, E.; Kirov, K.; Milanesio, D.; Maggiora, R.; Noble, C.; Contributors, JET

2018-04-01

The paper is dedicated to the characterisation of multi-strap ICRH antenna coupling to plasma. Relevance of traditional concept of coupling resistance to antennas with mutually coupled straps is revised and the importance of antenna port excitation consistency for application of the concept is highlighted. A method of antenna S-matrix measurement in presence of plasma is discussed allowing deeper insight into the problem of antenna-plasma coupling. The method is based entirely on the RF plant hardware and control facilities available at JET and it involves application of variable phasing between the antenna straps during the RF plant operations at  >100 kW. Unlike traditional techniques relying on low-power (~10 mW) network analysers, the applied antenna voltage amplitudes are relevant to practical conditions of ICRH operations; crucially, they are high enough to minimise possible effects of antenna loading non-linearity due to the RF sheath effects and other phenomena which could affect low-power measurements. The method has been successfully applied at JET to conventional 4-port ICRH antennas energised at frequencies of 33 MHz, 42 MHz and 51 MHz during L-mode plasma discharges while different gas injection modules (GIMs) were used to maintain comparable plasma densities during the pulses. The S-matrix assessment and its subsequent processing yielding ‘global’ antenna coupling resistances in conditions of equalised port maximum voltages allowed consistent description of antenna coupling to plasma at different strap phasing, operational frequencies and applied GIMs. Comprehensive experimental characterisation of mutually coupled antenna straps in presence of plasma also provided a unique opportunity for in-depth verification of TOPICA computer simulations.

Development of the Global Earthquake Model’s neotectonic fault database

USGS Publications Warehouse

Christophersen, Annemarie; Litchfield, Nicola; Berryman, Kelvin; Thomas, Richard; Basili, Roberto; Wallace, Laura; Ries, William; Hayes, Gavin P.; Haller, Kathleen M.; Yoshioka, Toshikazu; Koehler, Richard D.; Clark, Dan; Wolfson-Schwehr, Monica; Boettcher, Margaret S.; Villamor, Pilar; Horspool, Nick; Ornthammarath, Teraphan; Zuñiga, Ramon; Langridge, Robert M.; Stirling, Mark W.; Goded, Tatiana; Costa, Carlos; Yeats, Robert

2015-01-01

The Global Earthquake Model (GEM) aims to develop uniform, openly available, standards, datasets and tools for worldwide seismic risk assessment through global collaboration, transparent communication and adapting state-of-the-art science. GEM Faulted Earth (GFE) is one of GEM’s global hazard module projects. This paper describes GFE’s development of a modern neotectonic fault database and a unique graphical interface for the compilation of new fault data. A key design principle is that of an electronic field notebook for capturing observations a geologist would make about a fault. The database is designed to accommodate abundant as well as sparse fault observations. It features two layers, one for capturing neotectonic faults and fold observations, and the other to calculate potential earthquake fault sources from the observations. In order to test the flexibility of the database structure and to start a global compilation, five preexisting databases have been uploaded to the first layer and two to the second. In addition, the GFE project has characterised the world’s approximately 55,000 km of subduction interfaces in a globally consistent manner as a basis for generating earthquake event sets for inclusion in earthquake hazard and risk modelling. Following the subduction interface fault schema and including the trace attributes of the GFE database schema, the 2500-km-long frontal thrust fault system of the Himalaya has also been characterised. We propose the database structure to be used widely, so that neotectonic fault data can make a more complete and beneficial contribution to seismic hazard and risk characterisation globally.

[Huntington's disease: molecular foundations and implications in the characterisation of the neuronal mechanisms responsible for linguistic processing].

PubMed

Benítez-Burraco, A

Certain neuronal models of linguistic processing suggest that the basal ganglia play a key role in this processing, thanks to their integration within the so-called cortico-striato-cortical circuits. A comparative analysis, at a phenotypic and molecular level, of the pathologies, syndromes and disorders that entail a structural alteration and/or a dysfunction of the basal ganglia is essential for validating and optimising such models, as well as for achieving a suitable characterisation of the genetic program responsible for the development and functioning of the 'language organ'. One of the most significant pathologies in this respect is Huntington's disease, which is caused by the destruction of certain groups of neurons in the caudate nucleus. This type of analysis seems to confirm the hypothesis that, during linguistic processing, the basal ganglia would be responsible for planning and modulating the sequential tasks related to the so-called procedural (or computational or rule-applying) component of language. Equally plausible, however, is the hypothesis that, inside them, there would be regions that are specifically dedicated to processing the different (morphological and syntactical) rules that go to make up said component. Additionally, the nature of these subcortical structures and the function they perform would explain the simultaneous presence of an articulatory and a linguistic deficit in disorders in which the basal ganglia are affected. Lastly, this kind of analysis is also making it possible to characterise some of the genes that constitute the genetic program responsible for the development and functioning of this region of the brain and, by extension, of the 'language organ'.

Use of New Imaging CARTO® Segmentation Module Software to Facilitate Ablation of Ventricular Arrhythmias.

PubMed

Tovia-Brodie, Oholi; Belhassen, Bernard; Glick, Aharon; Shmilovich, Haim; Aviram, Galit; Rosso, Raphael; Michowitz, Yoav

2017-02-01

A new imaging software (CARTO® Segmentation Module, Biosense Webster) allows preprocedural 3-D reconstruction of all heart chambers based on cardiac CT. We describe our initial experience with the new module during ablation of ventricular arrhythmias. Eighteen consecutive patients with idiopathic ventricular arrhythmias or ischemic ventricular tachycardia (VT) were studied. In the latter group, a combined endocardial and epicardial ablation was performed. Of the 14 patients with idiopathic arrhythmias, 12 were ablated in the outflow tract (OT), 1 in the midseptal left ventricle, and 1 at the left posterior fascicular area; acute successful ablation was achieved in 11 (78.6%) patients. The procedure was discontinued due to close proximity of the arrhythmia origin to the coronary arteries (CA) in 2 patients. Acute successful uncomplicated ablation was achieved in all 4 patients with ischemic VT. During ablation in the coronary cusps commissures, the CARTO® Segmentation Module accurately defined the cusps anatomy. The precise anatomic location provided by the module assisted in successfully ablating when information from activation mapping was not optimal, by ablating at the opposite side of the cusps. In addition, by demonstrating the precise location of the CA, it allowed safe ablation of arrhythmias that originated in close proximity to the CA both in the OT area and the epicardium, eliminating the need for repeat angiography. The CARTO® Segmentation Module is useful for accurate definition of the exact anatomic location of ventricular arrhythmias and for safely ablating them especially in close proximity to the CA. © 2016 Wiley Periodicals, Inc.

A RFID specific participatory design approach to support design and implementation of real-time location systems in the operating room.

PubMed

Guédon, A C P; Wauben, L S G L; de Korne, D F; Overvelde, M; Dankelman, J; van den Dobbelsteen, J J

2015-01-01

Information technology, such as real-time location (RTL) systems using Radio Frequency IDentification (RFID) may contribute to overcome patient safety issues and high costs in healthcare. The aim of this work is to study if a RFID specific Participatory Design (PD) approach supports the design and the implementation of RTL systems in the Operating Room (OR). A RFID specific PD approach was used to design and implement two RFID based modules. The Device Module monitors the safety status of OR devices and the Patient Module tracks the patients' locations during their hospital stay. The PD principles 'multidisciplinary team', 'participation users (active involvement)' and 'early adopters' were used to include users from the RFID company, the university and the hospital. The design and implementation process consisted of two 'structured cycles' ('iterations'). The effectiveness of this approach was assessed by the acceptance in terms of level of use, continuity of the project and purchase. The Device Module included eight strategic and twelve tactical actions and the Patient Module included six strategic and twelve tactical actions. Both modules are now used on a daily basis and are purchased by the hospitals for continued use. The RFID specific PD approach was effective in guiding and supporting the design and implementation process of RFID technology in the OR. The multidisciplinary teams and their active participation provided insights in the social and the organizational context of the hospitals making it possible to better fit the technology to the hospitals' (future) needs.

Characterising the spatial variability of the tidal stream energy resource from floating turbines

NASA Astrophysics Data System (ADS)

Ward, Sophie; Neill, Simon; Robins, Peter

2017-04-01

The shelf seas, in particular the northwest European shelf seas surrounding the UK, contain significant tidal power potential. Tidal stream energy is both predictable and reliable providing that sites are well-selected based upon the hydrodynamic regime and the device specifics. In this high resolution three-dimensional tidal modelling study, we investigate how the tidal stream resource around the Welsh coast (UK) varies with water depth and location, with particular focus on the Pembrokeshire region. The potential extractable energy for a floating tidal stream energy converter is compared with that for a bottom-fixed device, highlighting the need to vary the resource characterisation criteria based on device specifics. We demonstrate how small variations in the tidal current speeds - with hub depth or due to tidal asymmetry - can lead to substantial variations in potential power output. Further, the results indicate that power generation from floating tidal energy converters will be more significantly influenced by tidal elevations in regions characterised by a lower tidal range (more progressive waves) than regions that experience a high tidal range (standing waves). As numerical modelling capacity improves and tidal stream energy converter technologies develop, ongoing improved quantification of the tidal resource is needed, as well as consideration of the possible feedbacks of the devices and energy extraction on the hydrodynamic regime and the surrounding area.

Non-destructive testing of satellite nozzles made of carbon fibre ceramic matrix composite, C/SiC

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rebelo Kornmeier, J.; Hofmann, M.; Schmidt, S.

Carbon fibre ceramic matrix composite materials, C/SiC, are excellent candidates as lightweight structural materials for high performance hot structures such as in aerospace applications. Satellite nozzles are manufactured from C/SiC, using, for instance, the Liquid Polymer Infiltration (LPI) process. In this article the applicability of different non-destructive analysis methods for the characterisation of C/SiC components will be discussed. By using synchrotron and neutron tomography it is possible to characterise the C/SiC material in each desired location or orientation. Synchrotron radiation using tomography on small samples with a resolution of 1.4 {mu}m, i.e. the fibre scale, was used to characterise threemore » dimensionally fibre orientation and integrity, matrix homogeneity and dimensions and distributions of micro pores. Neutron radiation tomography with a resolution of about 300 {mu}m was used to analyse the over-all C/SiC satellite nozzle component with respect to the fibre content. The special solder connection of a C/SiC satellite nozzle to a metallic ring was also successfully analysed by neutron tomography. In addition, the residual stress state of a temperature tested satellite nozzle was analysed non-destructively in depth by neutron diffraction. The results revealed almost zero stress for the principal directions, radial, axial and tangential, which can be considered to be the principal directions.« less

High Speed Videometric Monitoring of Rock Breakage

NASA Astrophysics Data System (ADS)

Allemand, J.; Shortis, M. R.; Elmouttie, M. K.

2018-05-01

Estimation of rock breakage characteristics plays an important role in optimising various industrial and mining processes used for rock comminution. Although little research has been undertaken into 3D photogrammetric measurement of the progeny kinematics, there is promising potential to improve the efficacy of rock breakage characterisation. In this study, the observation of progeny kinematics was conducted using a high speed, stereo videometric system based on laboratory experiments with a drop weight impact testing system. By manually tracking individual progeny through the captured video sequences, observed progeny coordinates can be used to determine 3D trajectories and velocities, supporting the idea that high speed video can be used for rock breakage characterisation purposes. An analysis of the results showed that the high speed videometric system successfully observed progeny trajectories and showed clear projection of the progeny away from the impact location. Velocities of the progeny could also be determined based on the trajectories and the video frame rate. These results were obtained despite the limitations of the photogrammetric system and experiment processes observed in this study. Accordingly there is sufficient evidence to conclude that high speed videometric systems are capable of observing progeny kinematics from drop weight impact tests. With further optimisation of the systems and processes used, there is potential for improving the efficacy of rock breakage characterisation from measurements with high speed videometric systems.

Increased entropy of signal transduction in the cancer metastasis phenotype.

PubMed

Teschendorff, Andrew E; Severini, Simone

2010-07-30

The statistical study of biological networks has led to important novel biological insights, such as the presence of hubs and hierarchical modularity. There is also a growing interest in studying the statistical properties of networks in the context of cancer genomics. However, relatively little is known as to what network features differ between the cancer and normal cell physiologies, or between different cancer cell phenotypes. Based on the observation that frequent genomic alterations underlie a more aggressive cancer phenotype, we asked if such an effect could be detectable as an increase in the randomness of local gene expression patterns. Using a breast cancer gene expression data set and a model network of protein interactions we derive constrained weighted networks defined by a stochastic information flux matrix reflecting expression correlations between interacting proteins. Based on this stochastic matrix we propose and compute an entropy measure that quantifies the degree of randomness in the local pattern of information flux around single genes. By comparing the local entropies in the non-metastatic versus metastatic breast cancer networks, we here show that breast cancers that metastasize are characterised by a small yet significant increase in the degree of randomness of local expression patterns. We validate this result in three additional breast cancer expression data sets and demonstrate that local entropy better characterises the metastatic phenotype than other non-entropy based measures. We show that increases in entropy can be used to identify genes and signalling pathways implicated in breast cancer metastasis and provide examples of de-novo discoveries of gene modules with known roles in apoptosis, immune-mediated tumour suppression, cell-cycle and tumour invasion. Importantly, we also identify a novel gene module within the insulin growth factor signalling pathway, alteration of which may predispose the tumour to metastasize. These results demonstrate that a metastatic cancer phenotype is characterised by an increase in the randomness of the local information flux patterns. Measures of local randomness in integrated protein interaction mRNA expression networks may therefore be useful for identifying genes and signalling pathways disrupted in one phenotype relative to another. Further exploration of the statistical properties of such integrated cancer expression and protein interaction networks will be a fruitful endeavour.

Testing Pearl Model In Three European Sites

NASA Astrophysics Data System (ADS)

Bouraoui, F.; Bidoglio, G.

The Plant Protection Product Directive (91/414/EEC) stresses the need of validated models to calculate predicted environmental concentrations. The use of models has become an unavoidable step before pesticide registration. In this context, European Commission, and in particular DGVI, set up a FOrum for the Co-ordination of pes- ticide fate models and their USe (FOCUS). In a complementary effort, DG research supported the APECOP project, with one of its objective being the validation and im- provement of existing pesticide fate models. The main topic of research presented here is the validation of the PEARL model for different sites in Europe. The PEARL model, actually used in the Dutch pesticide registration procedure, was validated in three well- instrumented sites: Vredepeel (the Netherlands), Brimstone (UK), and Lanna (Swe- den). A step-wise procedure was used for the validation of the PEARL model. First the water transport module was calibrated, and then the solute transport module, using tracer measurements keeping unchanged the water transport parameters. The Vrede- peel site is characterised by a sandy soil. Fourteen months of measurements were used for the calibration. Two pesticides were applied on the site: bentazone and etho- prophos. PEARL predictions were very satisfactory for both soil moisture content, and pesticide concentration in the soil profile. The Brimstone site is characterised by a cracking clay soil. The calibration was conducted on a time series measurement of 7 years. The validation consisted in comparing predictions and measurement of soil moisture at different soil depths, and in comparing the predicted and measured con- centration of isoproturon in the drainage water. The results, even if in good agreement with the measuremens, highlighted the limitation of the model when the preferential flow becomes a dominant process. PEARL did not reproduce well soil moisture pro- file during summer months, and also under-predicted the arrival of isoproturon to the drains. The Lanna site is characterised by s structured clay soil. PEARL was success- ful in predicting soil moisture profiles and the draining water. PEARL performed well in predicting the soil concentration of bentazone at different depth. However, since PEARL does not consider cracks in the soil, it did not predict well the peak concen- trations of bentazone in the drainage water. Along with the validation results for the three sites, a sensitivity analysis of the model is presented.

HDAC inhibition modulates hippocampus-dependent long-term memory for object location in a CBP-dependent manner

PubMed Central

Haettig, Jakob; Stefanko, Daniel P.; Multani, Monica L.; Figueroa, Dario X.; McQuown, Susan C.; Wood, Marcelo A.

2011-01-01

Transcription of genes required for long-term memory not only involves transcription factors, but also enzymatic protein complexes that modify chromatin structure. Chromatin-modifying enzymes, such as the histone acetyltransferase (HAT) CREB (cyclic-AMP response element binding) binding protein (CBP), are pivotal for the transcriptional regulation required for long-term memory. Several studies have shown that CBP and histone acetylation are necessary for hippocampus-dependent long-term memory and hippocampal long-term potentiation (LTP). Importantly, every genetically modified Cbp mutant mouse exhibits long-term memory impairments in object recognition. However, the role of the hippocampus in object recognition is controversial. To better understand how chromatin-modifying enzymes modulate long-term memory for object recognition, we first examined the role of the hippocampus in retrieval of long-term memory for object recognition or object location. Muscimol inactivation of the dorsal hippocampus prior to retrieval had no effect on long-term memory for object recognition, but completely blocked long-term memory for object location. This was consistent with experiments showing that muscimol inactivation of the hippocampus had no effect on long-term memory for the object itself, supporting the idea that the hippocampus encodes spatial information about an object (such as location or context), whereas cortical areas (such as the perirhinal or insular cortex) encode information about the object itself. Using location-dependent object recognition tasks that engage the hippocampus, we demonstrate that CBP is essential for the modulation of long-term memory via HDAC inhibition. Together, these results indicate that HDAC inhibition modulates memory in the hippocampus via CBP and that different brain regions utilize different chromatin-modifying enzymes to regulate learning and memory. PMID:21224411

VERDE Analytic Modules

DOE Office of Scientific and Technical Information (OSTI.GOV)

2008-01-15

The Verde Analytic Modules permit the user to ingest openly available data feeds about phenomenology (storm tracks, wind, precipitation, earthquake, wildfires, and similar natural and manmade power grid disruptions and forecast power outages, restoration times, customers outaged, and key facilities that will lose power. Damage areas are predicted using historic damage criteria of the affected area. The modules use a cellular automata approach to estimating the distribution circuits assigned to geo-located substations. Population estimates served within the service areas are located within 1 km grid cells and converted to customer counts by conversion through demographic estimation of households and commercialmore » firms within the population cells. Restoration times are estimated by agent-based simulation of restoration crews working according to utility published prioritization calibrated by historic performance.« less

Seismic Hazard Implication of the Seismotectonics of southern Africa

NASA Astrophysics Data System (ADS)

Midzi, Vunganai; Mulabisana, Thifelimbilu; Manzunzu, Brassnavy

2014-05-01

The work presented in this report / presentation was prepared as part of the requirements for the SIDA/IGCP Project 601 titled "Seismotectonics and Seismic Hazards in Africa" as well as part of the seismic source characterisation of the GEM-Africa Seismic hazard study. An effort was made to compile information necessary to prepare a seismotectonic map of Africa which can then be used in carrying out a seismic hazard assessment of the continent or locations within the continent. Information on major faults, fault plane solutions, geophysical data as well as stress data has so far been collected and included in a database for the southern Africa region. Reports published by several experts contributed much to the collected information. The seismicity data used are part of the earthquake catalogue being prepared for the GEM-Africa project, which includes historical and instrumental records as collected from various sources. An effort has been made to characterise the identified major faults and through further analysis investigate their possible impact on the seismic hazard of southern Africa.

The dog and cat population on Maio Island, Cape Verde: characterisation and prediction based on household survey and remotely sensed imagery.

PubMed

Lopes Antunes, Ana Carolina; Ducheyne, Els; Bryssinckx, Ward; Vieira, Sara; Malta, Manuel; Vaz, Yolanda; Nunes, Telmo; Mintiens, Koen

2015-11-04

The objective was to estimate and characterise the dog and cat population on Maio Island, Cape Verde. Remotely sensed imagery was used to document the number of houses across the island and a household survey was carried out in six administrative areas recording the location of each animal using a global positioning system instrument. Linear statistical models were applied to predict the dog and cat populations based on the number of houses found and according to various levels of data aggregation. In the surveyed localities, a total of 457 dogs and 306 cats were found. The majority of animals had owners and only a few had free access to outdoor activities. The estimated population size was 531 dogs [95% confidence interval (CI): 453-609] and 354 cats (95% CI: 275-431). Stray animals were not a concern on the island in contrast to the rest of the country.

Hydrogeochemical and isotopic characterisation of groundwater in a sand-dune phreatic aquifer on the northeastern coast of the province of Buenos Aires, Argentina.

PubMed

Carretero, Silvina C; Dapeña, Cristina; Kruse, Eduardo E

2013-01-01

This contribution presents the hydrochemical and isotopic characterisation of the phreatic aquifer located in the Partido de la Costa, province of Buenos Aires, Argentina. In the sand-dune barrier geomorphological environment, groundwater is mainly a low-salinity Ca-HCO3 and Na-HCO3-type, being in general suitable for drinking, whereas in the continental plain (silty clay sediments), groundwater is a Na-Cl type with high salinity and unsuitable for human consumption. The general isotopic composition of the area ranges from-6.8 to-4.3 ‰ for δ(18)O and from-39 to-21 ‰ for δ(2)H, showing that rainwater rapidly infiltrates into the sandy substrate and reaches the water table almost without significant modification in its isotopic composition. These analyses, combined with other chemical parameters, made it possible to corroborate that in the eastern area of the phreatic aquifer, there is no contamination from marine salt water.

Smart intimation and location of faults in distribution system

NASA Astrophysics Data System (ADS)

Hari Krishna, K.; Srinivasa Rao, B.

2018-04-01

Location of faults in the distribution system is one of the most complicated problems that we are facing today. Identification of fault location and severity of fault within a short time is required to provide continuous power supply but fault identification and information transfer to the operator is the biggest challenge in the distribution network. This paper proposes a fault location method in the distribution system based on Arduino nano and GSM module with flame sensor. The main idea is to locate the fault in the distribution transformer by sensing the arc coming out from the fuse element. The biggest challenge in the distribution network is to identify the location and the severity of faults under different conditions. Well operated transmission and distribution systems will play a key role for uninterrupted power supply. Whenever fault occurs in the distribution system the time taken to locate and eliminate the fault has to be reduced. The proposed design was achieved with flame sensor and GSM module. Under faulty condition, the system will automatically send an alert message to the operator in the distribution system, about the abnormal conditions near the transformer, site code and its exact location for possible power restoration.

Behavioral research in pigeons with ARENA: An automated remote environmental navigation apparatus

PubMed Central

Leising, Kenneth J.; Garlick, Dennis; Parenteau, Michael; Blaisdell, Aaron P.

2009-01-01

Three experiments established the effectiveness of an Automated Remote Environmental Navigation Apparatus (ARENA) developed in our lab to study behavioral processes in pigeons. The technology utilizes one or more wireless modules, each capable of presenting colored lights as visual stimuli to signal reward and of detecting subject peck responses. In Experiment 1, subjects were instrumentally shaped to peck at a single ARENA module following an unsuccessful autoshaping procedure. In Experiment 2, pigeons were trained with a simultaneous discrimination procedure during which two modules were illuminated different colors; pecks to one color (S+) were reinforced while pecks to the other color (S−) were not. Pigeons learned to preferentially peck the module displaying the S+. In Experiment 3, two modules were lit the same color concurrently from a set of six colors in a conditional discrimination task. For three of the colors pecks to the module in one location (e.g., upper quadrant) were reinforced while for the remaining colors pecks at the other module (e.g., lower quadrant) were reinforced. After learning this discrimination, the color-reinforced location assignments were reversed. Pigeons successfully acquired the reversal. ARENA is an automated system for open-field studies and a more ecologically valid alternative to the touchscreen. PMID:19429204

Method and apparatus for laser-controlled proton beam radiology

DOEpatents

Johnstone, Carol J.

1998-01-01

A proton beam radiology system provides cancer treatment and proton radiography. The system includes an accelerator for producing an H.sup.- beam and a laser source for generating a laser beam. A photodetachment module is located proximate the periphery of the accelerator. The photodetachment module combines the H.sup.- beam and laser beam to produce a neutral beam therefrom within a subsection of the H.sup.- beam. The photodetachment module emits the neutral beam along a trajectory defined by the laser beam. The photodetachment module includes a stripping foil which forms a proton beam from the neutral beam. The proton beam is delivered to a conveyance segment which transports the proton beam to a patient treatment station. The photodetachment module further includes a laser scanner which moves the laser beam along a path transverse to the cross-section of the H.sup.- beam in order to form the neutral beam in subsections of the H.sup.- beam. As the scanning laser moves across the H.sup.- beam, it similarly varies the trajectory of the proton beam emitted from the photodetachment module and in turn varies the target location of the proton beam upon the patient. Intensity modulation of the proton beam can also be achieved by controlling the output of the laser.

Method and apparatus for laser-controlled proton beam radiology

DOEpatents

Johnstone, C.J.

1998-06-02

A proton beam radiology system provides cancer treatment and proton radiography. The system includes an accelerator for producing an H{sup {minus}} beam and a laser source for generating a laser beam. A photodetachment module is located proximate the periphery of the accelerator. The photodetachment module combines the H{sup {minus}} beam and laser beam to produce a neutral beam therefrom within a subsection of the H{sup {minus}} beam. The photodetachment module emits the neutral beam along a trajectory defined by the laser beam. The photodetachment module includes a stripping foil which forms a proton beam from the neutral beam. The proton beam is delivered to a conveyance segment which transports the proton beam to a patient treatment station. The photodetachment module further includes a laser scanner which moves the laser beam along a path transverse to the cross-section of the H{sup {minus}} beam in order to form the neutral beam in subsections of the H{sup {minus}} beam. As the scanning laser moves across the H{sup {minus}} beam, it similarly varies the trajectory of the proton beam emitted from the photodetachment module and in turn varies the target location of the proton beam upon the patient. Intensity modulation of the proton beam can also be achieved by controlling the output of the laser. 9 figs.

Object-location memory in adults with autism spectrum disorder.

PubMed

Ring, Melanie; Gaigg, Sebastian B; Bowler, Dermot M

2015-10-01

This study tested implicit and explicit spatial relational memory in Autism Spectrum Disorder (ASD). Participants were asked to study pictures of rooms and pictures of daily objects for which locations were highlighted in the rooms. Participants were later tested for their memory of the object locations either by being asked to place objects back into their original locations or into new locations. Proportions of times when participants choose the previously studied locations for the objects irrespective of the instruction were used to derive indices of explicit and implicit memory [process-dissociation procedure, Jacoby, 1991, 1998]. In addition, participants performed object and location recognition and source memory tasks where they were asked about which locations belonged to the objects and which objects to the locations. The data revealed difficulty for ASD individuals in actively retrieving object locations (explicit memory) but not in subconsciously remembering them (implicit memory). These difficulties cannot be explained by difficulties in memory for objects or locations per se (i.e., the difficulty pertains to object-location relations). Together these observations lend further support to the idea that ASD is characterised by relatively circumscribed difficulties in relational rather than item-specific memory processes and show that these difficulties extend to the domain of spatial information. They also lend further support to the idea that memory difficulties in ASD can be reduced when support is provided at test. © 2015 International Society for Autism Research, Wiley Periodicals, Inc.

Modulation of a methane Bunsen flame by upstream perturbations

NASA Astrophysics Data System (ADS)

de Souza, T. Cardoso; Bastiaans, R. J. M.; De Goey, L. P. H.; Geurts, B. J.

2017-04-01

In this paper the effects of an upstream spatially periodic modulation acting on a turbulent Bunsen flame are investigated using direct numerical simulations of the Navier-Stokes equations coupled with the flamelet generated manifold (FGM) method to parameterise the chemistry. The premixed Bunsen flame is spatially agitated with a set of coherent large-scale structures of specific wave-number, K. The response of the premixed flame to the external modulation is characterised in terms of time-averaged properties, e.g. the average flame height ⟨H⟩ and the flame surface wrinkling ⟨W⟩. Results show that the flame response is notably selective to the size of the length scales used for agitation. For example, both flame quantities ⟨H⟩ and ⟨W⟩ present an optimal response, in comparison with an unmodulated flame, when the modulation scale is set to relatively low wave-numbers, 4π/L ≲ K ≲ 6π/L, where L is a characteristic scale. At the agitation scales where the optimal response is observed, the average flame height, ⟨H⟩, takes a clearly defined minimal value while the surface wrinkling, ⟨W⟩, presents an increase by more than a factor of 2 in comparison with the unmodulated reference case. Combined, these two response quantities indicate that there is an optimal scale for flame agitation and intensification of combustion rates in turbulent Bunsen flames.

The Computational Development of Reinforcement Learning during Adolescence

PubMed Central

Palminteri, Stefano; Coricelli, Giorgio; Blakemore, Sarah-Jayne

2016-01-01

Adolescence is a period of life characterised by changes in learning and decision-making. Learning and decision-making do not rely on a unitary system, but instead require the coordination of different cognitive processes that can be mathematically formalised as dissociable computational modules. Here, we aimed to trace the developmental time-course of the computational modules responsible for learning from reward or punishment, and learning from counterfactual feedback. Adolescents and adults carried out a novel reinforcement learning paradigm in which participants learned the association between cues and probabilistic outcomes, where the outcomes differed in valence (reward versus punishment) and feedback was either partial or complete (either the outcome of the chosen option only, or the outcomes of both the chosen and unchosen option, were displayed). Computational strategies changed during development: whereas adolescents’ behaviour was better explained by a basic reinforcement learning algorithm, adults’ behaviour integrated increasingly complex computational features, namely a counterfactual learning module (enabling enhanced performance in the presence of complete feedback) and a value contextualisation module (enabling symmetrical reward and punishment learning). Unlike adults, adolescent performance did not benefit from counterfactual (complete) feedback. In addition, while adults learned symmetrically from both reward and punishment, adolescents learned from reward but were less likely to learn from punishment. This tendency to rely on rewards and not to consider alternative consequences of actions might contribute to our understanding of decision-making in adolescence. PMID:27322574

Metaphysics and medical ethics: a reply.

PubMed Central

Gillett, G

1994-01-01

The total longitudinal form view of human beings is a metaphysical view which aims to locate our moral judgements about human embryos in a broader set of attitudes and characterisations. On this basis it has explanatory power and a real function in that it grounds our ethical discussion of embryos in other discourses. Contra Leavitt, this grounding suggests a broader criterion of relevance for metaphysical discussion than asking 'what comes out of' such a discussion for a particular ethical dilemma. PMID:8035442

Evaluation of the microclimate in poultry transport module drawers during the marketing process of end-of-lay hens from farm to slaughter.

PubMed

Richards, G J; Wilkins, L J; Weeks, C A; Knowles, T G; Brown, S N

2012-11-10

Changes in module drawer temperature and relative humidity were monitored for 24 commercial loads of hens. Mathematical models revealed significant differences in predicted drawer temperature depending on their location and the outside environmental temperature. Higher predicted temperatures were found in uppermost drawers of the top modules at the front of the lorry, and lower temperatures in drawers on the outer sides of modules and in those drawers in modules next to the back of the lorry in both the upper and lower modules during transport. In the lairage, drawer temperature generally decreased, except in drawers at the top of modules where temperatures increased. Temperature increases were most often recorded in modules which had been located at the rear of the lorry, which were generally cooler during transport. End-of-lay hens would appear to be exposed to a greater risk of cold stress rather than heat stress in the UK. Inspection of birds during transport, or upon arrival, should be directed to the bottom and side drawers of a load when looking for cold stress, and the top row of drawers (centre) of the top modules when looking for heat stress. The frequency of inspections should increase at times of high ambient temperature while the birds are being held in lairages. Adjusting the numbers of birds loaded per drawer according to bird condition and weather appears to be an effective mitigation strategy which is already in use commercially.

An abundant tissue macrophage population in the adult murine heart with a distinct alternatively-activated macrophage profile.

PubMed

Pinto, Alexander R; Paolicelli, Rosa; Salimova, Ekaterina; Gospocic, Janko; Slonimsky, Esfir; Bilbao-Cortes, Daniel; Godwin, James W; Rosenthal, Nadia A

2012-01-01

Cardiac tissue macrophages (cTMs) are a previously uncharacterised cell type that we have identified and characterise here as an abundant GFP(+) population within the adult Cx(3)cr1(GFP/+) knock-in mouse heart. They comprise the predominant myeloid cell population in the myocardium, and are found throughout myocardial interstitial spaces interacting directly with capillary endothelial cells and cardiomyocytes. Flow cytometry-based immunophenotyping shows that cTMs exhibit canonical macrophage markers. Gene expression analysis shows that cTMs (CD45(+)CD11b(+)GFP(+)) are distinct from mononuclear CD45(+)CD11b(+)GFP(+) cells sorted from the spleen and brain of adult Cx(3)cr1(GFP/+) mice. Gene expression profiling reveals that cTMs closely resemble alternatively-activated anti-inflammatory M2 macrophages, expressing a number of M2 markers, including Mrc1, CD163, and Lyve-1. While cTMs perform normal tissue macrophage homeostatic functions, they also exhibit a distinct phenotype, involving secretion of salutary factors (including IGF-1) and immune modulation. In summary, the characterisation of cTMs at the cellular and molecular level defines a potentially important role for these cells in cardiac homeostasis.

Characterisation and changes in the antioxidant system of chloroplasts and chromoplasts isolated from green and mature pepper fruits.

PubMed

Martí, M C; Camejo, D; Olmos, E; Sandalio, L M; Fernández-García, N; Jiménez, A; Sevilla, F

2009-07-01

Purification and characterisation of pepper (Capsicum annuum L) chloroplasts and chromoplasts isolated from commercial green, red and yellow mature fruits were undertaken. Induction of the synthesis of several antioxidants in organelles isolated from mature fruits was found. The ultrastructure of organelles and the presence and activity of SOD isozymes and enzymes involved in the ASC-GSH cycle, together with the non-enzymatic antioxidant content and some oxidative parameters, were analysed. It was found that lipids, rather than proteins, seem to be a target for oxidation in the chromoplasts. The ascorbate and glutathione contents were elicited during differentiation of chloroplasts into chromoplasts in both red and yellow fruits. The activity of SOD and of components of the ASC-GSH cycle was up-regulated, suggesting that these enzymes may play a role in the protection of plastids and could act as modulators of signal molecules such as O(2) ( -) and H(2)O(2) during fruit maturation. The presence of an Mn-SOD in chromoplasts isolated from yellow pepper fruits was also investigated in terms of structural and antioxidant differences between the two cultivars.

The therapeutic potential of Na+ and Ca2+ channel blockers in pain management.

PubMed

Sabido-David, Cibele; Faravelli, Laura; Salvati, Patricia

2004-10-01

Chronic pain affects a large percentage of the population, representing a socio-economic burden. Current treatments are characterised by suboptimal efficacy and/or side effects that limit their use. Among several approaches to treating chronic pain, voltage-sensitive Ca(2+) and Na(+) channels are promising targets. This review evaluates the preclinical evidence that supports the involvement of these targets, with specific attention to those subtypes that appear more strictly correlated with pain generation and sustainment, as well as those compounds that modulate the activity of Ca(2+) and/or Na(+) channels that are currently in clinical development for chronic pain conditions.

Identification and characterisation of ROS modulator 1 in Lampetra japonica.

PubMed

Zhao, Chunhui; Feng, Bin; Cao, Ying; Xie, Peng; Xu, Jie; Pang, Yue; Liu, Xin; Li, Qingwei

2013-08-01

Reactive oxygen species (ROS) are a heterogeneous group of highly reactive molecules that oxidise targets in biological systems. ROS are also considered important immune regulators. In this study, we identified a homologue of reactive oxygen species modulator 1 (Romo1) in the Japanese lamprey (Lampetra japonica). The L japonica Romo1 (Lj-Romo1) gene shares high sequence homology with the Romo1 genes of jawed vertebrates. Real-time quantitative PCR demonstrated the wide distribution of Lj-Romo1 in lamprey tissues. Furthermore, after the lampreys were stimulated with lipopolysaccharide (LPS), the level of Lj-Romo1 mRNA was markedly up-regulated in the liver, gill, kidney, and intestine tissues. Lj-Romo1 was localised to the mitochondria and has the capacity to increase the ROS level in cells. The results obtained in the present study will help us to understand the roles of Romo1 in ROS production and innate immune responses in jawless vertebrates. Copyright © 2013 Elsevier Ltd. All rights reserved.

[Antioxidant and anti-inflammatory modulation of exercise during aging].

PubMed

Galle, Fernando Alexis; Martella, Diana; Bresciani, Guilherme

2018-06-10

Aging is characterised by a gradual loss of the functional reserve. This, along with the fostering of sedentary habits and the increase in risk factors, causes a deterioration of antioxidant defences and an increase of the circulatory levels of inflammatory and oxidative markers, boosting a low-rate chronic inflammation, defined as inflamm-aging. This phenomenon is present in the aetiopathology of chronic diseases, as well as in cognitive deterioration cases associated with aging. The objective of this review is to describe the modulation of antioxidant and anti-inflammatory effects of physical exercise of moderate intensity and volume in the elderly. Evidence of its effectiveness as a non-pharmacological resource is presented, which decreases some deleterious effects of aging. This is mainly due to its neuroprotective action, the increase in circulating anti-inflammatory markers, and the improvement of antioxidant defence derived from its practice. Copyright © 2018 SEGG. Publicado por Elsevier España, S.L.U. All rights reserved.

Magneto-orbital helices: a novel coupling mechanism between magnetism and ferroelectricity in multiferroic CaMn7O12

NASA Astrophysics Data System (ADS)

Radaelli, Paolo G.; Perks, Natasha; Johnson, Roger D.; Martin, Christine; Chapon, Laurent

2013-03-01

The trigonal quadruple perovskite CaMn7O12 displays one of the largest magnetically induced ferroelectric polarisations measured to date (2870 μC m-2). Ferroelectricity appears below 90 K, together with an incommensurate helical magnetic modulation, and cannot be explained within the framework developed for cycloidal magnets. We report an unprecedented magneto-orbital texture in multiferroic CaMn7O12, which is directly connected to ferroelectricity. X-ray and neutron diffraction characterisation of the structural and magnetic modulations in these ``magneto-orbital helices'', and analysis of magnetic exchange shows that orbital order is crucial in stabilising a chiral magnetic structure. Additionally, the presence of a global structural rotation enables the magnetic helicity to couple with the lattice, giving rise to electric polarisation. These novel principles open up the possibility of discovering new multiferroics with even larger polarization and higher transition temperatures. Work at Oxford was funded by EPSRC grant EP/J003557/1.

The influence of sex-linked genetic mechanisms on attention and impulsivity

PubMed Central

Trent, Simon; Davies, William

2012-01-01

It is now generally agreed that there are inherent sex differences in healthy individuals across a number of neurobiological domains (including brain structure, neurochemistry, and cognition). Moreover, there is a burgeoning body of evidence highlighting sex differences within neuropsychiatric populations (in terms of the rates of incidence, clinical features/progression, neurobiology and pathology). Here, we consider the extent to which attention and impulsivity are sexually dimorphic in healthy populations and the extent to which sex might modulate the expression of disorders characterised by abnormalities in attention and/or impulsivity such as attention deficit hyperactivity disorder (ADHD), autism and addiction. We then discuss general genetic mechanisms that might underlie sex differences in attention and impulsivity before focussing on specific positional and functional candidate sex-linked genes that are likely to influence these cognitive processes. Identifying novel sex-modulated molecular targets should ultimately enable us to develop more effective therapies in disorders associated with attentional/impulsive dysfunction. PMID:21983394

The modulational instability in the extended Hasegawa-Mima equation with a finite Larmor radius

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gallagher, S.; Hnat, B.; Rowlands, G.

2012-12-15

The effects of the finite Larmor radius on the generation of zonal flows by the four-wave modulational instability are investigated using an extended form of the Hasegawa-Mima equation. Growth rates of the zonal mode are quantified using analytical predictions from a four-mode truncated model, as well as from direct numerical simulation of the nonlinear extended Hasegawa-Mima equation. We not only consider purely zonal flows but also examine the generic oblique case and show that, for small Larmor radii, off-axis modes may become dominant. We find a key parameter M{sub {rho}} which characterises the behaviour of the system due to changesmore » in the Larmor radius. We find that, similarly to previous results obtained by changing the driving wave amplitude, two separate dynamical regimes can be accessed. These correspond to oscillatory energy transfer between zonal flows and a driving wave and the fully saturated zonal flow.« less

Development of a Thermoelectric Module Suitable for Vehicles and Based on CoSb3 Manufactured Close to Production

NASA Astrophysics Data System (ADS)

Klein Altstedde, Mirko; Sottong, Reinhard; Freitag, Oliver; Kober, Martin; Dreißigacker, Volker; Zabrocki, Knud; Szabo, Patric

2015-06-01

Despite the ongoing electrification of vehicle propulsion systems, vehicles with combustion engines will continue to bear the brunt of passenger services worldwide for the next few decades. As a result, the German Aerospace Center Institute of Vehicle Concepts, the Institute of Materials Research and the Institute of Technical Thermodynamics have focused on utilising the exhaust heat of internal combustion engines by means of thermoelectric generators (TEGs). Their primary goal is the development of cost-efficient TEGs with long-term stability and maximised energy yield. In addition to the overall TEG system design, the development of long-term stable, efficient thermoelectric modules (TEMs) for high-temperature applications is a great challenge. This paper presents the results of internal development work and reveals an expedient module design for use in TEGs suitable for vehicles. The TEM requirements identified, which were obtained by means of experiments on the test vehicle and test bench, are described first. Doped semiconductor materials were produced and characterised by production methods capable of being scaled up in order to represent series application. The results in terms of thermoelectric properties (Seebeck coefficient, electrical conductivity and thermal conductivity) were used for the simulative design of a thermoelectric module using a constant-property model and with the aid of FEM calculations. Thermomechanical calculations of material stability were carried out in addition to the TEM's thermodynamic and thermoelectric design. The film sequence within the module represented a special challenge. Multilayer films facilitated adaptation of the thermal and mechanical properties of plasma-sprayed films. A joint which dispenses with solder additives was also possible using multilayer films. The research resulted in a functionally-optimised module design, which was enhanced for use in motor vehicles using process flexibility and close-to-production manufacturing methods.

Stochastic blockmodeling of the modules and core of the Caenorhabditis elegans connectome.

PubMed

Pavlovic, Dragana M; Vértes, Petra E; Bullmore, Edward T; Schafer, William R; Nichols, Thomas E

2014-01-01

Recently, there has been much interest in the community structure or mesoscale organization of complex networks. This structure is characterised either as a set of sparsely inter-connected modules or as a highly connected core with a sparsely connected periphery. However, it is often difficult to disambiguate these two types of mesoscale structure or, indeed, to summarise the full network in terms of the relationships between its mesoscale constituents. Here, we estimate a community structure with a stochastic blockmodel approach, the Erdős-Rényi Mixture Model, and compare it to the much more widely used deterministic methods, such as the Louvain and Spectral algorithms. We used the Caenorhabditis elegans (C. elegans) nervous system (connectome) as a model system in which biological knowledge about each node or neuron can be used to validate the functional relevance of the communities obtained. The deterministic algorithms derived communities with 4-5 modules, defined by sparse inter-connectivity between all modules. In contrast, the stochastic Erdős-Rényi Mixture Model estimated a community with 9 blocks or groups which comprised a similar set of modules but also included a clearly defined core, made of 2 small groups. We show that the "core-in-modules" decomposition of the worm brain network, estimated by the Erdős-Rényi Mixture Model, is more compatible with prior biological knowledge about the C. elegans nervous system than the purely modular decomposition defined deterministically. We also show that the blockmodel can be used both to generate stochastic realisations (simulations) of the biological connectome, and to compress network into a small number of super-nodes and their connectivity. We expect that the Erdős-Rényi Mixture Model may be useful for investigating the complex community structures in other (nervous) systems.

Bilateral Functional Connectivity of the Basal Ganglia in Patients with Parkinson’s Disease and Its Modulation by Dopaminergic Treatment

PubMed Central

Little, Simon; Tan, Huiling; Anzak, Anam; Pogosyan, Alek; Kühn, Andrea; Brown, Peter

2013-01-01

Parkinson’s disease is characterised by excessive subcortical beta oscillations. However, little is known about the functional connectivity of the two basal ganglia across hemispheres and specifically the role beta plays in this. We recorded local field potentials from the subthalamic nucleus bilaterally in 23 subjects with Parkinson’s disease at rest, on and off medication. We found suppression of low beta power in response to levodopa (t22 = −4.4, p<0.001). There was significant coherence between the two sides in the beta range in 19 of the subjects. Coherence was selectively attenuated in the low beta range following levodopa (t22 = −2.7; p = 0.01). We also separately analysed amplitude co-modulation and phase synchronisation in the beta band and found significant amplitude co-modulation and phase locking values in 17 and 16 subjects respectively, off medication. There was a dissociable effect of levodopa on these measures, with a significant suppression only in low beta phase locking value (t22 = −2.8, p = 0.01) and not amplitude co-modulation. The absolute mean values of amplitude co-modulation (0.40±0.03) and phase synchronisation (0.29±0.02) off medication were, however, relatively low, suggesting that the two basal ganglia networks may have to be approached separately with independent sensing and stimulation during adaptive deep brain stimulation. In addition, our findings highlight the functional distinction between the lower and upper beta frequency ranges and between amplitude co-modulation and phase synchronization across subthalamic nuclei. PMID:24376574

Noise-induced modulation of the relaxation kinetics around a non-equilibrium steady state of non-linear chemical reaction networks.

PubMed

Ramaswamy, Rajesh; Sbalzarini, Ivo F; González-Segredo, Nélido

2011-01-28

Stochastic effects from correlated noise non-trivially modulate the kinetics of non-linear chemical reaction networks. This is especially important in systems where reactions are confined to small volumes and reactants are delivered in bursts. We characterise how the two noise sources confinement and burst modulate the relaxation kinetics of a non-linear reaction network around a non-equilibrium steady state. We find that the lifetimes of species change with burst input and confinement. Confinement increases the lifetimes of all species that are involved in any non-linear reaction as a reactant. Burst monotonically increases or decreases lifetimes. Competition between burst-induced and confinement-induced modulation may hence lead to a non-monotonic modulation. We quantify lifetime as the integral of the time autocorrelation function (ACF) of concentration fluctuations around a non-equilibrium steady state of the reaction network. Furthermore, we look at the first and second derivatives of the ACF, each of which is affected in opposite ways by burst and confinement. This allows discriminating between these two noise sources. We analytically derive the ACF from the linear Fokker-Planck approximation of the chemical master equation in order to establish a baseline for the burst-induced modulation at low confinement. Effects of higher confinement are then studied using a partial-propensity stochastic simulation algorithm. The results presented here may help understand the mechanisms that deviate stochastic kinetics from its deterministic counterpart. In addition, they may be instrumental when using fluorescence-lifetime imaging microscopy (FLIM) or fluorescence-correlation spectroscopy (FCS) to measure confinement and burst in systems with known reaction rates, or, alternatively, to correct for the effects of confinement and burst when experimentally measuring reaction rates.

Identifying gender differences in reported occupational information from three US population-based case-control studies.

PubMed

Locke, Sarah J; Colt, Joanne S; Stewart, Patricia A; Armenti, Karla R; Baris, Dalsu; Blair, Aaron; Cerhan, James R; Chow, Wong-Ho; Cozen, Wendy; Davis, Faith; De Roos, Anneclaire J; Hartge, Patricia; Karagas, Margaret R; Johnson, Alison; Purdue, Mark P; Rothman, Nathaniel; Schwartz, Kendra; Schwenn, Molly; Severson, Richard; Silverman, Debra T; Friesen, Melissa C

2014-12-01

Growing evidence suggests that gender-blind assessment of exposure may introduce exposure misclassification, but few studies have characterised gender differences across occupations and industries. We pooled control responses to job-specific, industry-specific and exposure-specific questionnaires (modules) that asked detailed questions about work activities from three US population-based case-control studies to examine gender differences in work tasks and their frequencies. We calculated the ratio of female-to-male controls that completed each module. For four job modules (assembly worker, machinist, health professional, janitor/cleaner) and for subgroups of jobs that completed those modules, we evaluated gender differences in task prevalence and frequency using χ(2) and Mann-Whitney U tests, respectively. The 1360 female and 2245 male controls reported 6033 and 12 083 jobs, respectively. Gender differences in female:male module completion ratios were observed for 39 of 45 modules completed by ≥20 controls. Gender differences in task prevalence varied in direction and magnitude. For example, female janitors were significantly more likely to polish furniture (79% vs 44%), while male janitors were more likely to strip floors (73% vs 50%). Women usually reported more time spent on tasks than men. For example, the median hours per week spent degreasing for production workers in product manufacturing industries was 6.3 for women and 3.0 for men. Observed gender differences may reflect actual differences in tasks performed or differences in recall, reporting or perception, all of which contribute to exposure misclassification and impact relative risk estimates. Our findings reinforce the need to capture subject-specific information on work tasks. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

A Study of the Time Dependence in Fracture Processes Relating to Service Life Prediction of Adhesive Joints and Advanced Composites.

DTIC Science & Technology

1981-04-30

fluid temperature should exceed 145°F. The flow control module contains all the hydraulic circuit elements necessary for both the pressure line to and...are contained in three basic modules : 1) the hydraulic power supply, 2) a flow control module containing valving, accumulators and filters, and 3) the...hydraulic transient overpressures, is located in the flow control module , as are the high and low pressure filters. The load frame (MTS Systems Corp

STS-96 crew takes part in payload Interface Verification Test

NASA Technical Reports Server (NTRS)

1999-01-01

In the SPACEHAB Facility, STS-96 Mission Specialist Valery Tokarev (in foreground) of the Russian Space Agency closes a container, part of the equipment that will be in the SPACEHAB module on mission STS-96. Behind Tokarev are Pilot Rick Husband (left) and Mission Specialist Dan Barry (right). Other crew members at KSC for a payload Interface Verification Test for the upcoming mission to the International Space Station are Commander Kent Rominger and Mission Specialists Ellen Ochoa, Tamara Jernigan and Julie Payette. Mission STS-96 carries the SPACEHAB Logistics Double Module, which has equipment to further outfit the International Space Station service module and equipment that can be off-loaded from the early U.S. assembly flights. The SPACEHAB carries internal logistics and resupply cargo for station outfitting, plus an external Russian cargo crane to be mounted to the exterior of the Russian station segment and used to perform space walking maintenance activities. The double module stowage provides capacity of up to 10,000 lbs. with the ability to accommodate powered payloads, four external rooftop stowage locations, four double-rack locations (two powered), up to 61 bulkhead-mounted middeck locker locations, and floor storage for large unique items and Soft Stowage. STS-96 is targeted to launch May 20 about 9:32 a.m.

Earth-Science Data Co-Locating Tool

NASA Technical Reports Server (NTRS)

Lee, Seungwon; Pan, Lei; Block, Gary L.

2012-01-01

This software is used to locate Earth-science satellite data and climate-model analysis outputs in space and time. This enables the direct comparison of any set of data with different spatial and temporal resolutions. It is written in three separate modules that are clearly separated for their functionality and interface with other modules. This enables a fast development of supporting any new data set. In this updated version of the tool, several new front ends are developed for new products. This software finds co-locatable data pairs for given sets of data products and creates new data products that share the same spatial and temporal coordinates. This facilitates the direct comparison between the two heterogeneous datasets and the comprehensive and synergistic use of the datasets.

Autonomous Vehicles for Wave Energy Site Characterisation and monitoring in the Atlantic areas: North Scotland and Portugal

NASA Astrophysics Data System (ADS)

McIlvenny, J.; Campuzano, F.; Goddijn-Murphy, L.

2016-02-01

Surface autonomous marine robots allow the collection of environmental data for weeks or months at a time in difficult to reach or extreme oceanic environments. Wave glider technology has improved in recent years and is now capable of carrying instruments from different manufacturers1, such as ADCP, wave modules, and acoustic sensors2. Here we investigate the suitability of surface based robotic platforms for the collection of environmental data for the renewable energy industry. The Waveglider robotic platform was chosen for this study, representing one of the most advanced platforms in its class. Two sites were chosen: Farr point in North Scotland and Nazare in Portugal. Both study sites are potential locations for wave energy development. We present the results of two simultaneous field campaigns using Waveglider technology. Of particular importance to the study were data integrity and accuracy, platform ability, performance and durability and risk. The project's main aims were to test the platform's capabilities and collect wave data from two wave energy lease sites. The wave data from the Waveglider are compared to nearshore wave height and period data from simultaneous overhead passes by the altimeter satellite AltiKa3. In addition, Waverider buoys were also deployed and recording wave characteristics at both sites visited by the Waveglider. We present the preliminary inter-comparison between the three wave datasets at both sites and assess the performance of the Waveglider technology.

Back-clocking of Fe2+/Fe1+ spin states in a H2-producing catalyst by advanced EPR

NASA Astrophysics Data System (ADS)

Stathi, Panagiota; Mitrikas, George; Sanakis, Yiannis; Louloudi, Maria; Deligiannakis, Yiannis

2013-10-01

A mononuclear Fe-(P(PPh2)3) ((P(PPh2)3) = tris[2-diphenylphospino)ethyl]phosphine) catalyst was studied in situ under catalytic conditions using advanced electron paramagnetic resonance (EPR) techniques. Fe-(P(PPh2)3) efficiently catalyses H2 production using HCOOH as substrate. Dual-mode continuous-wave (CW) EPR, used to study the initial Fe2+(S = 2) state, shows that the complex is characterised by a - rather small - zero field splitting parameter Δ = 0.45 cm-1 and geff = 8.0. In the presence of HCOOH substrate the complex evolves and a unique Fe1+(S = 1/2) state is trapped. The Fe1+ atom is coordinated by four 31P nuclei in a pseudo-C3 symmetry. Only a small fraction of the Fe1+ spin density is delocalised onto the 31P atoms. Four-pulse electron spin echo envelope modulation (ESEEM) and two-dimensional hyperfine sublevel correlation spectroscopy (2D-HYSCORE) data reveal the existence of two types of 1H couplings. One corresponds to weak, purely dipolar coupling, tentatively assigned to phenyl protons. The most important is a - rather unusual - 1H coupling with negative Aiso (-2.75 MHz) and strong dipolar part (T = 5.5 MHz). This 1H is located on the pseudo-C3 symmetry axis of the Fe1+-(P(PPh2)3-HCOO- complex where one substrate molecule, formate anion, is coordinated on the Fe1+ atom.

Representing Where along with What Information in a Model of a Cortical Patch

PubMed Central

Roudi, Yasser; Treves, Alessandro

2008-01-01

Behaving in the real world requires flexibly combining and maintaining information about both continuous and discrete variables. In the visual domain, several lines of evidence show that neurons in some cortical networks can simultaneously represent information about the position and identity of objects, and maintain this combined representation when the object is no longer present. The underlying network mechanism for this combined representation is, however, unknown. In this paper, we approach this issue through a theoretical analysis of recurrent networks. We present a model of a cortical network that can retrieve information about the identity of objects from incomplete transient cues, while simultaneously representing their spatial position. Our results show that two factors are important in making this possible: A) a metric organisation of the recurrent connections, and B) a spatially localised change in the linear gain of neurons. Metric connectivity enables a localised retrieval of information about object identity, while gain modulation ensures localisation in the correct position. Importantly, we find that the amount of information that the network can retrieve and retain about identity is strongly affected by the amount of information it maintains about position. This balance can be controlled by global signals that change the neuronal gain. These results show that anatomical and physiological properties, which have long been known to characterise cortical networks, naturally endow them with the ability to maintain a conjunctive representation of the identity and location of objects. PMID:18369416

Software Engineering Practices: Their Impact on the Design of a Program Maintenance Manual.

DTIC Science & Technology

1982-12-01

listinjs. Myers raef. 18) st at es: Since we already have the zoi?, 1’hYlnot let it SerVe as-he loic documentation? . diin3 ocmtati-)n such as a flowchart ...Recommended Locations for Coiments 1. ht the beginnning of eaz- module lnzlude the module name the current date, the module’sfunction, its’inputs and outputs

Optimum filters for narrow-band frequency modulation.

NASA Technical Reports Server (NTRS)

Shelton, R. D.

1972-01-01

The results of a computer search for the optimum type of bandpass filter for low-index angle-modulated signals are reported. The bandpass filters are discussed in terms of their low-pass prototypes. Only filter functions with constant numerators are considered. The pole locations for the optimum filters of several cases are shown in a table. The results are fairly independent of modulation index and bandwidth.

Design and long-term monitoring of DSC/CIGS tandem solar module

NASA Astrophysics Data System (ADS)

Vildanova, M. F.; Nikolskaia, A. B.; Kozlov, S. S.; Shevaleevskiy, O. I.

2015-11-01

This paper describes the design and development of tandem dye-sensitized/Cu(In, Ga)Se (DSC/CIGS) PV modules. The tandem PV module comprised of the top DSC module and a bottom commercial 0,8 m2 CIGS module. The top DSC module was made of 10 DSC mini-modules with the field size of 20 × 20 cm2 each. Tandem DSC/CIGS PV modules were used for providing the long-term monitoring of energy yield and electrical parameters in comparison with standalone CIGS modules under outdoor conditions. The outdoor test facility, containing solar modules of both types and a measurement unit, was located on the roof of the Institute of Biochemical Physics in Moscow. The data obtained during monitoring within the 2014 year period has shown the advantages of the designed tandem DSC/CIGS PV-modules over the conventional CIGS modules, especially for cloudy weather and low-intensity irradiation conditions.

Microwave determination of location and speed of an object inside a pipe

DOEpatents

Sinha, Dipen N.

2010-12-14

Apparatus and method are described for measuring the location and speed of an object, such as instrumentation on a movable platform, disposed within a pipe, using continuous-wave, amplitude-modulated microwave radiation.

KENNEDY SPACE CENTER, FLA. - In the Space Station Processing Facility, STS-120 Mission Specialist Piers Sellers looks over the Japanese Experiment Module (JEM) Pressurized Module. Known as Kibo, the JEM consists of six components: two research facilities -- the Pressurized Module and Exposed Facility; a Logistics Module attached to each of them; a Remote Manipulator System; and an Inter-Orbit Communication System unit. Kibo also has a scientific airlock through which experiments are transferred and exposed to the external environment of space. The various components of JEM will be assembled in space over the course of three Space Shuttle missions. The STS-120 mission will deliver the second of three Station connecting modules, Node 2, which attaches to the end of U.S. Lab. It will provide attach locations for the Japanese laboratory, European laboratory, the Centrifuge Accommodation Module and later Multi-Purpose Logistics Modules. The addition of Node 2 will complete the U.S. core of the International Space Station.

NASA Image and Video Library

2003-07-18

KENNEDY SPACE CENTER, FLA. - In the Space Station Processing Facility, STS-120 Mission Specialist Piers Sellers looks over the Japanese Experiment Module (JEM) Pressurized Module. Known as Kibo, the JEM consists of six components: two research facilities -- the Pressurized Module and Exposed Facility; a Logistics Module attached to each of them; a Remote Manipulator System; and an Inter-Orbit Communication System unit. Kibo also has a scientific airlock through which experiments are transferred and exposed to the external environment of space. The various components of JEM will be assembled in space over the course of three Space Shuttle missions. The STS-120 mission will deliver the second of three Station connecting modules, Node 2, which attaches to the end of U.S. Lab. It will provide attach locations for the Japanese laboratory, European laboratory, the Centrifuge Accommodation Module and later Multi-Purpose Logistics Modules. The addition of Node 2 will complete the U.S. core of the International Space Station.

KENNEDY SPACE CENTER, FLA. - In the Space Station Processing Facility, STS-120 Mission Specialist Michael Foreman looks over the Japanese Experiment Module (JEM) Pressurized Module. Known as Kibo, the JEM consists of six components: two research facilities -- the Pressurized Module and Exposed Facility; a Logistics Module attached to each of them; a Remote Manipulator System; and an Inter-Orbit Communication System unit. Kibo also has a scientific airlock through which experiments are transferred and exposed to the external environment of space. The various components of JEM will be assembled in space over the course of three Space Shuttle missions. The STS-120 mission will deliver the second of three Station connecting modules, Node 2, which attaches to the end of U.S. Lab. It will provide attach locations for the Japanese laboratory, European laboratory, the Centrifuge Accommodation Module and later Multi-Purpose Logistics Modules. The addition of Node 2 will complete the U.S. core of the International Space Station.

NASA Image and Video Library

2003-07-18

KENNEDY SPACE CENTER, FLA. - In the Space Station Processing Facility, STS-120 Mission Specialist Michael Foreman looks over the Japanese Experiment Module (JEM) Pressurized Module. Known as Kibo, the JEM consists of six components: two research facilities -- the Pressurized Module and Exposed Facility; a Logistics Module attached to each of them; a Remote Manipulator System; and an Inter-Orbit Communication System unit. Kibo also has a scientific airlock through which experiments are transferred and exposed to the external environment of space. The various components of JEM will be assembled in space over the course of three Space Shuttle missions. The STS-120 mission will deliver the second of three Station connecting modules, Node 2, which attaches to the end of U.S. Lab. It will provide attach locations for the Japanese laboratory, European laboratory, the Centrifuge Accommodation Module and later Multi-Purpose Logistics Modules. The addition of Node 2 will complete the U.S. core of the International Space Station.

Distributed Attention Is Implemented through Theta-Rhythmic Gamma Modulation.

PubMed

Landau, Ayelet Nina; Schreyer, Helene Marianne; van Pelt, Stan; Fries, Pascal

2015-08-31

When subjects monitor a single location, visual target detection depends on the pre-target phase of an ∼8 Hz brain rhythm. When multiple locations are monitored, performance decrements suggest a division of the 8 Hz rhythm over the number of locations, indicating that different locations are sequentially sampled. Indeed, when subjects monitor two locations, performance benefits alternate at a 4 Hz rhythm. These performance alternations were revealed after a reset of attention to one location. Although resets are common and important events for attention, it is unknown whether, in the absence of resets, ongoing attention samples stimuli in alternation. Here, we examined whether spatially specific attentional sampling can be revealed by ongoing pre-target brain rhythms. Visually induced gamma-band activity plays a role in spatial attention. Therefore, we hypothesized that performance on two simultaneously monitored stimuli can be predicted by a 4 Hz modulation of gamma-band activity. Brain rhythms were assessed with magnetoencephalography (MEG) while subjects monitored bilateral grating stimuli for a unilateral target event. The corresponding contralateral gamma-band responses were subtracted from each other to isolate spatially selective, target-related fluctuations. The resulting lateralized gamma-band activity (LGA) showed opposite pre-target 4 Hz phases for detected versus missed targets. The 4 Hz phase of pre-target LGA accounted for a 14.5% modulation in performance. These findings suggest that spatial attention is a theta-rhythmic sampling process that is continuously ongoing, with each sampling cycle being implemented through gamma-band synchrony. Copyright © 2015 Elsevier Ltd. All rights reserved.

Contextual control over task-set retrieval.

PubMed

Crump, Matthew J C; Logan, Gordon D

2010-11-01

Contextual cues signaling task likelihood or the likelihood of task repetition are known to modulate the size of switch costs. We follow up on the finding by Leboe, Wong, Crump, and Stobbe (2008) that location cues predictive of the proportion of switch or repeat trials modulate switch costs. Their design employed one cue per task, whereas our experiment employed two cues per task, which allowed separate assessment of modulations to the cue-repetition benefit, a measure of lower level cue-encoding processes, and to the task-alternation cost, a measure of higher level processes representing task-set information. We demonstrate that location information predictive of switch proportion modulates performance at the level of task-set representations. Furthermore, we demonstrate that contextual control occurs even when subjects are unaware of the associations between context and switch likelihood. We discuss the notion that contextual information provides rapid, unconscious control over the extent to which prior task-set representations are retrieved in the service of guiding online performance.

Route Advising in a Dynamic Environment - A High-Tech Approach

NASA Astrophysics Data System (ADS)

Firdhous, M. F. M.; Basnayake, D. L.; Kodithuwakku, K. H. L.; Hatthalla, N. K.; Charlin, N. W.; Bandara, P. M. R. I. K.

Finding the optimal path between two locations in the Colombo city is not a straight forward task, because of the complex road system and the huge traffic jams etc. This paper presents a system to find the optimal driving direction between two locations within the Colombo city, considering road rules (one way, two ways or fully closed in both directions). The system contains three main modules - core module, web module and mobile module, additionally there are two user interfaces one for normal users and the other for administrative users. Both these interfaces can be accessed using a web browser or a GPRS enabled mobile phone. The system is developed based on the Geographic Information System (GIS) technology. GIS is considered as the best option to integrate hardware, software, and data for capturing, managing, analyzing, and displaying all forms of geographically referenced information. The core of the system is MapServer (MS4W) used along with the other supporting technologies such as PostGIS, PostgreSQL, pgRouting, ASP.NET and C#.

Software Assists in Extensive Environmental Auditing

NASA Technical Reports Server (NTRS)

Callac, Christopher; Matherne, Charlie

2002-01-01

The Base Enivronmental Management System (BEMS) is a Web-based application program for managing and tracking audits by the Environmental Office of Stennis Space Center in conformity with standard 14001 of the International Organization for Standardization (ISO 14001). (This standard specifies requirements for an environmental-management system.) BEMS saves time by partly automating what were previously manual processes for creating audit checklists; recording and tracking audit results; issuing, tracking, and implementing corrective-action requests (CARs); tracking continuous improvements (CIs); and tracking audit results and statistics. BEMS consists on an administration module and an auditor module. As its name suggests, the administration module is used to administer the audit. It helps administrators to edit the list of audit questions; edit the list of audit locations; assign manditory questions to locations; track, approve, and edit CARs; and edit completed audits. The auditor module is used by auditors to perform audits and record audit results: It helps the auditors to create audit checklists, complete audits, view completed audits, create CARs, record and acknowledge CIs, and generate reports from audit results.

Software Assists in Extensive Environmental Auditing

NASA Technical Reports Server (NTRS)

Callac, Christopher; Matherne, Charlie

2003-01-01

The Base Environmental Management System (BEMS) is a Web-based application program for managing and tracking audits by the Environmental Office of Stennis Space Center in conformity with standard 14001 of the International Organization for Standardization (ISO 14001). (This standard specifies requirements for an environmental-management system.) BEMS saves time by partly automating what were previously manual processes for creating audit checklists; recording and tracking audit results; issuing, tracking, and implementing corrective-action requests (CARs); tracking continuous improvements (CIs); and tracking audit results and statistics. BEMS consists of an administration module and an auditor module. As its name suggests, the administration module is used to administer the audit. It helps administrators to edit the list of audit questions; edit the list of audit locations; assign mandatory questions to locations; track, approve, and edit CARs; and edit completed audits. The auditor module is used by auditors to perform audits and record audit results: it helps the auditors to create audit checklists, complete audits, view completed audits, create CARs, record and acknowledge CIs, and generate reports from audit results.

Software Assists in Extensive Environmental Auditing

NASA Technical Reports Server (NTRS)

Callac, Christopher; Matherne, Charlie; Selinsky, T.

2002-01-01

The Base Environmental Management System (BEMS) is a Web-based application program for managing and tracking audits by the Environmental Office of Stennis Space Center in conformity with standard 14001 of the International Organization for Standardization (ISO 14001). (This standard specifies requirements for an environmental-management system.) BEMS saves time by partly automating what were previously manual processes for creating audit checklists; recording and tracking audit results; issuing, tracking, and implementing corrective-action requests (CARs); tracking continuous improvements (CIs); and tracking audit results and statistics. BEMS consists of an administration module and an auditor module. As its name suggests, the administration module is used to administer the audit. It helps administrators to edit the list of audit questions; edit the list of audit locations; assign mandatory questions to locations; track, approve, and edit CARs; and edit completed audits. The auditor module is used by auditors to perform audits and record audit results: it helps the auditors to create audit checklists, complete audits, view completed audits, create CARs, record and acknowledge CIs, and generate reports from audit results.

The MUSICA MetOp/IASI H2O and δD products: characterisation and long-term comparison to NDACC/FTIR data

NASA Astrophysics Data System (ADS)

Wiegele, A.; Schneider, M.; Hase, F.; Barthlott, S.; García, O. E.; Sepúlveda, E.; González, Y.; Blumenstock, T.; Raffalski, U.; Gisi, M.; Kohlhepp, R.

2014-04-01

Within the project MUSICA (MUlti-platform remote Sensing of Isotopologues for investigating the Cycle of Atmospheric water) ground- and space-based remote sensing as well as in-situ datasets of tropospheric water vapour isotopologues are provided. The space-based remote-sensing dataset is produced from spectra measured by the IASI (Infrared Atmospheric Sounding Interferometer) sensor and is potentially available on a global scale. Here, we present the MUSICA IASI data for three different geophysical locations (subtropics, mid-latitudes, and arctic) and we provide a comprehensive characterisation of the complex nature of such space-based isotopologue remote sensing products. The quality assessment study is complemented by a comparison to MUSICA's ground-based FTIR (Fourier-Transform InfraRed) remote sensing data retrieved from the spectra recorded at three different locations within the framework of NDACC (Network for the Detection of Atmospheric Composition Change). We confirm that IASI is able to measure tropospheric H2O profiles with a vertical resolution of about 4 km and a random error of about 10%. In addition IASI can observe middle tropospheric δD that adds complementary value to IASI's middle tropospheric H2O observations. Our study is both, a theoretical and an empirical proof that IASI has the capability for a global observation of middle tropospheric water vapour isotopologues on a daily timescale and at a quality that is sufficiently high for water cycle research purposes.

The MUSICA MetOp/IASI H2O and δD products: characterisation and long-term comparison to NDACC/FTIR data

NASA Astrophysics Data System (ADS)

Wiegele, A.; Schneider, M.; Hase, F.; Barthlott, S.; García, O. E.; Sepúlveda, E.; González, Y.; Blumenstock, T.; Raffalski, U.; Gisi, M.; Kohlhepp, R.

2014-08-01

Within the project MUSICA (MUlti-platform remote Sensing of Isotopologues for investigating the Cycle of Atmospheric water) ground- and space-based remote sensing as well as in situ data sets of tropospheric water vapour isotopologues are provided. The space-based remote-sensing data set is produced from spectra measured by the IASI (Infrared Atmospheric Sounding Interferometer) sensor and is potentially available on a global scale. Here, we present the MUSICA IASI data for three different geophysical locations (subtropics, midlatitudes, and Arctic), and we provide a comprehensive characterisation of the complex nature of such space-based isotopologue remote-sensing products. The quality assessment study is complemented by a comparison to MUSICA's ground-based FTIR (Fourier Transform InfraRed) remote-sensing data retrieved from the spectra recorded at three different locations within the framework of NDACC (Network for the Detection of Atmospheric Composition Change). We confirm that IASI is able to measure tropospheric H2O profiles with a vertical resolution of about 4 km and a random error of about 10%. In addition IASI can observe middle tropospheric δD that adds complementary value to IASI's middle tropospheric H2O observations. Our study presents theoretical and empirical proof that IASI has the capability for a global observation of middle tropospheric water vapour isotopologues on a daily timescale and at a quality that is sufficiently high for water cycle research purposes.

Volcano-tectonic structures, gravity and helium in geothermal areas of Tuscany and Latium (Vulsini volcanic district), Italy

USGS Publications Warehouse

Di, Filippo M.; Lombardi, S.; Nappi, G.; Reimer, G.M.; Renzulli, A.; Toro, B.

1999-01-01

Since the early 1980s, geological and structural mapping, gravity, and helium soil-gas studies have been performed in the eastern sector of the Vulsini Volcanic District (Roman Magmatic Province) in an attempt to locate potential geothermal reservoirs. This area is characterised by an anomalous geothermal gradient of > 100??C/km, and by widespread hydrothermal mineralization, thermal springs, high gas fluxes, and fossil and current travertine deposits. The results of these surveys indicate the existence of a number of fault systems, with N-S and E-W structures that appear to be superimposed on older NW-SE and NE-SW features. Comparison of the results of the various studies also reveals differences in permeability and potential reservoir structures at depth.Since the early 1980s, geological and structural mapping, gravity, and helium soil-gas studies have been performed in the eastern sector of the Vulsini Volcanic District (Roman Magmatic Province) in an attempt to locate potential geothermal reservoirs. This area is characterised by an anomalous geothermal gradient of > 100??C/km, and by widespread hydrothermal mineralization, thermal springs, high gas fluxes, and fossil and current travertine deposits. The results of these surveys indicate the existence of a number of fault systems, with N-S and E-W structures that appear to be superimposed on older NW-SE and NE-SW features. Comparison of the results of the various studies also reveals differences in permeability and potential reservoir structures at depth.

Reduced order modelling in searches for continuous gravitational waves - I. Barycentring time delays

NASA Astrophysics Data System (ADS)

Pitkin, M.; Doolan, S.; McMenamin, L.; Wette, K.

2018-06-01

The frequencies and phases of emission from extra-solar sources measured by Earth-bound observers are modulated by the motions of the observer with respect to the source, and through relativistic effects. These modulations depend critically on the source's sky-location. Precise knowledge of the modulations are required to coherently track the source's phase over long observations, for example, in pulsar timing, or searches for continuous gravitational waves. The modulations can be modelled as sky-location and time-dependent time delays that convert arrival times at the observer to the inertial frame of the source, which can often be the Solar system barycentre. We study the use of reduced order modelling for speeding up the calculation of this time delay for any sky-location. We find that the time delay model can be decomposed into just four basis vectors, and with these the delay for any sky-location can be reconstructed to sub-nanosecond accuracy. When compared to standard routines for time delay calculation in gravitational wave searches, using the reduced basis can lead to speed-ups of 30 times. We have also studied components of time delays for sources in binary systems. Assuming eccentricities <0.25, we can reconstruct the delays to within 100 s of nanoseconds, with best case speed-ups of a factor of 10, or factors of two when interpolating the basis for different orbital periods or time stamps. In long-duration phase-coherent searches for sources with sky-position uncertainties, or binary parameter uncertainties, these speed-ups could allow enhancements in their scopes without large additional computational burdens.

DNDO Report: Predicting Solar Modulation Potentials for Modeling Cosmic Background Radiation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Behne, Patrick Alan

The modeling of the detectability of special nuclear material (SNM) at ports and border crossings requires accurate knowledge of the background radiation at those locations. Background radiation originates from two main sources, cosmic and terrestrial. Cosmic background is produced by high-energy galactic cosmic rays (GCR) entering the atmosphere and inducing a cascade of particles that eventually impact the earth’s surface. The solar modulation potential represents one of the primary inputs to modeling cosmic background radiation. Usosokin et al. formally define solar modulation potential as “the mean energy loss [per unit charge] of a cosmic ray particle inside the heliosphere…” Modulationmore » potential, a function of elevation, location, and time, shares an inverse relationship with cosmic background radiation. As a result, radiation detector thresholds require adjustment to account for differing background levels, caused partly by differing solar modulations. Failure to do so can result in higher rates of false positives and failed detection of SNM for low and high levels of solar modulation potential, respectively. This study focuses on solar modulation’s time dependence, and seeks the best method to predict modulation for future dates using Python. To address the task of predicting future solar modulation, we utilize both non-linear least squares sinusoidal curve fitting and cubic spline interpolation. This material will be published in transactions of the ANS winter meeting of November, 2016.« less

KENNEDY SPACE CENTER, FLA. - Astronaut Soichi Noguchi (left), with the National Space Development Agency of Japan (NASDA), points to data on the console during a Multi-Element Integrated Test (MEIT) of the U.S. Node 2 and the Japanese Experiment Module (JEM) in the Space Station Processing Facility. The JEM, developed by NASDA, is Japan's primary contribution to the Station. It will enhance the unique research capabilities of the orbiting complex by providing an additional environment for astronauts to conduct science experiments. Noguchi is assigned to mission STS-114 as a mission specialist. Node 2 provides attach locations for the Japanese laboratory, as well as European laboratory, the Centrifuge Accommodation Module and, eventually, Multipurpose Logistics Modules. Installation of the module will complete the U.S. Core of the ISS.

NASA Image and Video Library

2003-09-03

KENNEDY SPACE CENTER, FLA. - Astronaut Soichi Noguchi (left), with the National Space Development Agency of Japan (NASDA), points to data on the console during a Multi-Element Integrated Test (MEIT) of the U.S. Node 2 and the Japanese Experiment Module (JEM) in the Space Station Processing Facility. The JEM, developed by NASDA, is Japan's primary contribution to the Station. It will enhance the unique research capabilities of the orbiting complex by providing an additional environment for astronauts to conduct science experiments. Noguchi is assigned to mission STS-114 as a mission specialist. Node 2 provides attach locations for the Japanese laboratory, as well as European laboratory, the Centrifuge Accommodation Module and, eventually, Multipurpose Logistics Modules. Installation of the module will complete the U.S. Core of the ISS.

KENNEDY SPACE CENTER, FLA. - In the Space Station Processing Facility, astronaut Soichi Noguchi (right), with the National Space Development Agency of Japan (NASDA), stands inside the Japanese Experiment Module (JEM) that is undergoing a Multi-Element Integrated Test (MEIT) with the U.S. Node 2. The JEM, developed by NASDA, is Japan's primary contribution to the Station. It will enhance the unique research capabilities of the orbiting complex by providing an additional environment for astronauts to conduct science experiments. Noguchi is assigned to mission STS-114 as a mission specialist. Node 2 provides attach locations for the Japanese laboratory, as well as European laboratory, the Centrifuge Accommodation Module and, eventually, Multipurpose Logistics Modules. Installation of the module will complete the U.S. Core of the ISS.

NASA Image and Video Library

2003-09-03

KENNEDY SPACE CENTER, FLA. - In the Space Station Processing Facility, astronaut Soichi Noguchi (right), with the National Space Development Agency of Japan (NASDA), stands inside the Japanese Experiment Module (JEM) that is undergoing a Multi-Element Integrated Test (MEIT) with the U.S. Node 2. The JEM, developed by NASDA, is Japan's primary contribution to the Station. It will enhance the unique research capabilities of the orbiting complex by providing an additional environment for astronauts to conduct science experiments. Noguchi is assigned to mission STS-114 as a mission specialist. Node 2 provides attach locations for the Japanese laboratory, as well as European laboratory, the Centrifuge Accommodation Module and, eventually, Multipurpose Logistics Modules. Installation of the module will complete the U.S. Core of the ISS.

KENNEDY SPACE CENTER, FLA. - Astronaut Soichi Noguchi (left), with the National Space Development Agency of Japan (NASDA), works at a console during a Multi-Element Integrated Test (MEIT) of the U.S. Node 2 and the Japanese Experiment Module (JEM) in the Space Station Processing Facility. The JEM, developed by NASDA, is Japan's primary contribution to the Station. It will enhance the unique research capabilities of the orbiting complex by providing an additional environment for astronauts to conduct science experiments. Noguchi is assigned to mission STS-114 as a mission specialist. Node 2 provides attach locations for the Japanese laboratory, as well as European laboratory, the Centrifuge Accommodation Module and, eventually, Multipurpose Logistics Modules. Installation of the module will complete the U.S. Core of the ISS.

NASA Image and Video Library

2003-09-03

KENNEDY SPACE CENTER, FLA. - Astronaut Soichi Noguchi (left), with the National Space Development Agency of Japan (NASDA), works at a console during a Multi-Element Integrated Test (MEIT) of the U.S. Node 2 and the Japanese Experiment Module (JEM) in the Space Station Processing Facility. The JEM, developed by NASDA, is Japan's primary contribution to the Station. It will enhance the unique research capabilities of the orbiting complex by providing an additional environment for astronauts to conduct science experiments. Noguchi is assigned to mission STS-114 as a mission specialist. Node 2 provides attach locations for the Japanese laboratory, as well as European laboratory, the Centrifuge Accommodation Module and, eventually, Multipurpose Logistics Modules. Installation of the module will complete the U.S. Core of the ISS.

Vertical view of Apollo 16 landing site located Descartes area lunar nearside

NASA Technical Reports Server (NTRS)

1971-01-01

A vertical view of the Apollo 16 landing site located in the Descartes area lunar nearside. The overlay indicates the location of the proposed touchdown point for the Apollo 16 Lunar Module. Descartes is located west of the Sea of Nectar and southwest of the Sea of Tranquility. This photograph was taken with a 500mm lens camera from lunar orbit by the Apollo 14 crew.

Viewing the body modulates tactile receptive fields.

PubMed

Haggard, Patrick; Christakou, Anastasia; Serino, Andrea

2007-06-01

Tactile discrimination performance depends on the receptive field (RF) size of somatosensory cortical (SI) neurons. Psychophysical masking effects can reveal the RF of an idealized "virtual" somatosensory neuron. Previous studies show that top-down factors strongly affect tactile discrimination performance. Here, we show that non-informative vision of the touched body part influences tactile discrimination by modulating tactile RFs. Ten subjects performed spatial discrimination between touch locations on the forearm. Performance was improved when subjects saw their forearm compared to viewing a neutral object in the same location. The extent of visual information was relevant, since restricted view of the forearm did not have this enhancing effect. Vibrotactile maskers were placed symmetrically on either side of the tactile target locations, at two different distances. Overall, masking significantly impaired discrimination performance, but the spatial gradient of masking depended on what subjects viewed. Viewing the body reduced the effect of distant maskers, but enhanced the effect of close maskers, as compared to viewing a neutral object. We propose that viewing the body improves functional touch by sharpening tactile RFs in an early somatosensory map. Top-down modulation of lateral inhibition could underlie these effects.

Apparatuses to support photovoltaic modules

DOEpatents

Ciasulli, John; Jones, Jason

2017-08-22

Methods and apparatuses to support photovoltaic ("PV") modules are described. A saddle bracket has a mounting surface to support one or more PV modules over a tube, a gusset coupled to the mounting surface, and a mounting feature coupled to the gusset to couple to the tube. A grounding washer has a first portion to couple to a support; and a second portion coupled to the first portion to provide a ground path to a PV module. A PV system has a saddle bracket; a PV module over the saddle bracket; and a grounding washer coupled to the saddle bracket and the PV module. Saddle brackets can be coupled to a torque tube at predetermined locations. PV modules can be coupled to the saddle brackets.

A typology of female sex work in the Metropolitan Region of Santiago, Chile.

PubMed

Belmar, Julieta; Stuardo, Valeria; Folch, Cinta; Carvajal, Bielka; Clunes, Maria José; Montoliu, Alexandra; Casabona, Jordi

2018-04-01

In Chile, sex work takes place covertly in a variety of venues and locations. Formative research using time-location sampling methods is important in order to understand the nature of this diversity. This study used qualitative methods to develop a typology of female sex work in the Metropolitan Region of Santiago, Chile, using semi-structured interviews, focus groups and ethnographic fieldwork during visits to sex work venues. The study identified seven types of venue, which reflect the context and regulatory framework of the country and the structural vulnerabilities that affect female sex workers in Chile. These venues and locations include: cafés con piernas (coffee with legs); nightclubs, topless bars and cabarets; brothels; hotels; street and highway soliciting; massage parlours; and private residences. Formative research methods were helpful in identifying and characterising the venues and locations in which sex work occurred. Barriers to accessing and mapping specific locations were also identified. Recommendations for addressing these barriers include working with non-governmental organisations to map venues and initiate contact with the populations of interest. A comprehensive typology of sex work in the Metropolitan Region of Santiago, Chile, is an essential element for future time-location sampling and bio-behavioural research in the context of second-generation surveillance for HIV and sexually transmitted infections in Chile.

A "Do-It-Yourself" phenotyping system: measuring growth and morphology throughout the diel cycle in rosette shaped plants.

PubMed

Dobrescu, Andrei; Scorza, Livia C T; Tsaftaris, Sotirios A; McCormick, Alistair J

2017-01-01

Improvements in high-throughput phenotyping technologies are rapidly expanding the scope and capacity of plant biology studies to measure growth traits. Nevertheless, the costs of commercial phenotyping equipment and infrastructure remain prohibitively expensive for wide-scale uptake, while academic solutions can require significant local expertise. Here we present a low-cost methodology for plant biologists to build their own phenotyping system for quantifying growth rates and phenotypic characteristics of Arabidopsis thaliana rosettes throughout the diel cycle. We constructed an image capture system consisting of a near infra-red (NIR, 940 nm) LED panel with a mounted Raspberry Pi NoIR camera and developed a MatLab-based software module (iDIEL Plant) to characterise rosette expansion. Our software was able to accurately segment and characterise multiple rosettes within an image, regardless of plant arrangement or genotype, and batch process image sets. To further validate our system, wild-type Arabidopsis plants (Col-0) and two mutant lines with reduced Rubisco contents, pale leaves and slow growth phenotypes ( 1a3b and 1a2b ) were grown on a single plant tray. Plants were imaged from 9 to 24 days after germination every 20 min throughout the 24 h light-dark growth cycle (i.e. the diel cycle). The resulting dataset provided a dynamic and uninterrupted characterisation of differences in rosette growth and expansion rates over time for the three lines tested. Our methodology offers a straightforward solution for setting up automated, scalable and low-cost phenotyping facilities in a wide range of lab environments that could greatly increase the processing power and scalability of Arabidopsis soil growth experiments.

Spectrum-Modulating Fiber-Optic Sensors

NASA Technical Reports Server (NTRS)

Beheim, Glenn; Fritsch, Klaus

1989-01-01

Family of spectrum-modulating fiber-optic sensors undergoing development for use in aircraft-engine control systems. Fiber-optic sensors offer advantages of small size, high bandwidth, immunity to electromagnetic interference, and light weight. Furthermore, they reduce number of locations on aircraft to which electrical power has to be supplied.

Bioluminescence Truth Data Measurement and Signature Detection

DTIC Science & Technology

2007-09-30

cell phone based communications module attached to the top of the piling. A cell phone tower represents communication of data to shore. Also shown...representing each Kilroy installation are located based on GPS coordinates telemetered by the cell phone module. Icons point in direction of most recently

Molecular genetic classification in Prader-Willi syndrome: a multisite cohort study.

PubMed

Butler, Merlin G; Hartin, Samantha N; Hossain, Waheeda A; Manzardo, Ann M; Kimonis, Virginia; Dykens, Elisabeth; Gold, June Anne; Kim, Soo-Jeong; Weisensel, Nicolette; Tamura, Roy; Miller, Jennifer L; Driscoll, Daniel J

2018-05-05

Prader-Willi syndrome (PWS) is due to errors in genomic imprinting. PWS is recognised as the most common known genetic cause of life-threatening obesity. This report summarises the frequency and further characterises the PWS molecular classes and maternal age effects. High-resolution microarrays, comprehensive chromosome 15 genotyping and methylation-specific multiplex ligation probe amplification were used to describe and further characterise molecular classes of maternal disomy 15 (UPD15) considering maternal age. We summarised genetic data from 510 individuals with PWS and 303 (60%) had the 15q11-q13 deletion; 185 (36%) with UPD15 and 22 (4%) with imprinting defects. We further characterised UPD15 findings into subclasses based on the presence (size, location) or absence of loss of heterozygosity (LOH). Additionally, significantly older mothers (mean age=32.5 years vs 27.7 years) were found in the UPD15 group (n=145) compared with the deletion subtype (n=200). We report on molecular classes in PWS using advanced genomic technology in the largest cohort to date. LOH patterns in UPD15 may impact the risk of having a second genetic condition if the mother carries a recessive mutant allele in the isodisomic region on chromosome 15. The risk of UPD15 may also increase with maternal age. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Characterisation and expression of microRNAs in developing wings of the neotropical butterfly Heliconius melpomene

PubMed Central

2011-01-01

Background Heliconius butterflies are an excellent system for studies of adaptive convergent and divergent phenotypic traits. Wing colour patterns are used as signals to both predators and potential mates and are inherited in a Mendelian manner. The underlying genetic mechanisms of pattern formation have been studied for many years and shed light on broad issues, such as the repeatability of evolution. In Heliconius melpomene, the yellow hindwing bar is controlled by the HmYb locus. MicroRNAs (miRNAs) are important post-transcriptional regulators of gene expression that have key roles in many biological processes, including development. miRNAs could act as regulators of genes involved in wing development, patterning and pigmentation. For this reason we characterised miRNAs in developing butterfly wings and examined differences in their expression between colour pattern races. Results We sequenced small RNA libraries from two colour pattern races and detected 142 Heliconius miRNAs with homology to others found in miRBase. Several highly abundant miRNAs were differentially represented in the libraries between colour pattern races. These candidates were tested further using Northern blots, showing that differences in expression were primarily due to developmental stage rather than colour pattern. Assembly of sequenced reads to the HmYb region identified hme-miR-193 and hme-miR-2788; located 2380 bp apart in an intergenic region. These two miRNAs are expressed in wings and show an upregulation between 24 and 72 hours post-pupation, indicating a potential role in butterfly wing development. A search for miRNAs in all available H. melpomene BAC sequences (~ 2.5 Mb) did not reveal any other miRNAs and no novel miRNAs were predicted. Conclusions Here we describe the first butterfly miRNAs and characterise their expression in developing wings. Some show differences in expression across developing pupal stages and may have important functions in butterfly wing development. Two miRNAs were located in the HmYb region and were expressed in developing pupal wings. Future work will examine the expression of these miRNAs in different colour pattern races and identify miRNA targets among wing patterning genes. PMID:21266089

Characterisation of tropomyosin and paramyosin as vaccine candidate molecules for the poultry red mite, Dermanyssus gallinae.

PubMed

Wright, Harry W; Bartley, Kathryn; Huntley, John F; Nisbet, Alasdair J

2016-10-12

Dermanyssus gallinae is the most economically important haematophagous ectoparasite in commercial egg laying flocks worldwide. It infests the hens during the night where it causes irritation leading to restlessness, pecking and in extreme cases anaemia and increased cannibalism. Due to an increase in the occurrence of acaricide-resistant D. gallinae populations, new control strategies are required and vaccination may offer a sustainable alternative to acaricides. In this study, recombinant forms of D. gallinae tropomyosin (Der g 10) and paramyosin (Der g 11) were produced, characterised and tested as vaccine candidate molecules. The D. gallinae paramyosin (Der g 11) coding sequence was characterised and recombinant versions of Der g 11 and D. gallinae tropomyosin (Der g 10) were produced. Hens were immunised with the recombinant proteins and the resulting antibodies were fed to D. gallinae and mite mortality evaluated. Sections of mites were probed with anti- Der g 11 and Der g 10 antibodies to identify the tissue distribution of these protein in D. gallinae. The entire coding sequence of Der g 11 was 2,622 bp encoding 874 amino acid residues. Immunohistochemical staining of mite sections revealed that Der g 10 and Der g 11 were located throughout D. gallinae tissues. In phylogenetic analyses of these proteins both clustered with orthologues from tick species rather than with orthologues from astigmatid mites. Antibodies raised in hens against recombinant forms of these proteins significantly increased D. gallinae mortality, by 19 % for Der g 10 (P < 0.001) and by 23 % for Der g 11 (P = 0.009) when fed to the mites using an in vitro feeding device. This study has shown that Der g 10 and Der g 11 were located ubiquitously throughout D. gallinae and that antibodies raised against recombinant versions of these proteins can be used to significantly increase D. gallinae mortality in an in vitro feeding assay. When comparing archived data for all recombinant and native proteins assessed as vaccines using this in vitro feeding assay, Der g 10 and Der g 11 ranked highly and performed better than some of the pools of native proteins.

Characterisation and expression of microRNAs in developing wings of the neotropical butterfly Heliconius melpomene.

PubMed

Surridge, Alison K; Lopez-Gomollon, Sara; Moxon, Simon; Maroja, Luana S; Rathjen, Tina; Nadeau, Nicola J; Dalmay, Tamas; Jiggins, Chris D

2011-01-26

Heliconius butterflies are an excellent system for studies of adaptive convergent and divergent phenotypic traits. Wing colour patterns are used as signals to both predators and potential mates and are inherited in a Mendelian manner. The underlying genetic mechanisms of pattern formation have been studied for many years and shed light on broad issues, such as the repeatability of evolution. In Heliconius melpomene, the yellow hindwing bar is controlled by the HmYb locus. MicroRNAs (miRNAs) are important post-transcriptional regulators of gene expression that have key roles in many biological processes, including development. miRNAs could act as regulators of genes involved in wing development, patterning and pigmentation. For this reason we characterised miRNAs in developing butterfly wings and examined differences in their expression between colour pattern races. We sequenced small RNA libraries from two colour pattern races and detected 142 Heliconius miRNAs with homology to others found in miRBase. Several highly abundant miRNAs were differentially represented in the libraries between colour pattern races. These candidates were tested further using Northern blots, showing that differences in expression were primarily due to developmental stage rather than colour pattern. Assembly of sequenced reads to the HmYb region identified hme-miR-193 and hme-miR-2788; located 2380 bp apart in an intergenic region. These two miRNAs are expressed in wings and show an upregulation between 24 and 72 hours post-pupation, indicating a potential role in butterfly wing development. A search for miRNAs in all available H. melpomene BAC sequences (~2.5 Mb) did not reveal any other miRNAs and no novel miRNAs were predicted. Here we describe the first butterfly miRNAs and characterise their expression in developing wings. Some show differences in expression across developing pupal stages and may have important functions in butterfly wing development. Two miRNAs were located in the HmYb region and were expressed in developing pupal wings. Future work will examine the expression of these miRNAs in different colour pattern races and identify miRNA targets among wing patterning genes.

Orion Crew Module Move

NASA Image and Video Library

2017-11-17

The Orion crew module for Exploration Mission-1 was moved into the thermal chamber in the Neil Armstrong Operations and Checkout Building high bay at NASA's Kennedy Space Center in Florida. The crew module will undergo a thermal cycle test to assess the workmanship of critical hardware and structural locations. The test also demonstrates crew module subsystem operations in a thermally stressing environment to confirm no damage or anomalous hardware conditions as a result of the test. The Orion spacecraft will launch atop NASA's Space Launch System rocket on its first uncrewed integrated flight.

Orion Crew Module Move

NASA Image and Video Library

2017-11-17

Technicians assist as the Orion crew module for Exploration Mission-1 is moved toward the thermal chamber in the Neil Armstrong Operations and Checkout Building high bay at NASA's Kennedy Space Center in Florida. The crew module will undergo a thermal cycle test to assess the workmanship of critical hardware and structural locations. The test also demonstrates crew module subsystem operations in a thermally stressing environment to confirm no damage or anomalous hardware conditions as a result of the test. The Orion spacecraft will launch atop NASA's Space Launch System rocket on its first uncrewed integrated flight.

Module Degradation Mechanisms Studied by a Multi-Scale Approach

DOE Office of Scientific and Technical Information (OSTI.GOV)

Johnston, Steve; Al-Jassim, Mowafak; Hacke, Peter

2016-11-21

A key pathway to meeting the Department of Energy SunShot 2020 goals is to reduce financing costs by improving investor confidence through improved photovoltaic (PV) module reliability. A comprehensive approach to further understand and improve PV reliability includes characterization techniques and modeling from module to atomic scale. Imaging techniques, which include photoluminescence, electroluminescence, and lock-in thermography, are used to locate localized defects responsible for module degradation. Small area samples containing such defects are prepared using coring techniques and are then suitable and available for microscopic study and specific defect modeling and analysis.

Pulse width modulation inverter with battery charger

DOEpatents

Slicker, James M.

1985-01-01

An inverter is connected between a source of DC power and a three-phase AC induction motor, and a microprocessor-based circuit controls the inverter using pulse width modulation techniques. In the disclosed method of pulse width modulation, both edges of each pulse of a carrier pulse train are equally modulated by a time proportional to sin .theta., where .theta. is the angular displacement of the pulse center at the motor stator frequency from a fixed reference point on the carrier waveform. The carrier waveform frequency is a multiple of the motor stator frequency. The modulated pulse train is then applied to each of the motor phase inputs with respective phase shifts of 120.degree. at the stator frequency. Switching control commands for electronic switches in the inverter are stored in a random access memory (RAM) and the locations of the RAM are successively read out in a cyclic manner, each bit of a given RAM location controlling a respective phase input of the motor. The DC power source preferably comprises rechargeable batteries and all but one of the electronic switches in the inverter can be disabled, the remaining electronic switch being part of a "flyback" DC-DC converter circuit for recharging the battery.

Pulse width modulation inverter with battery charger

NASA Technical Reports Server (NTRS)

Slicker, James M. (Inventor)

1985-01-01

An inverter is connected between a source of DC power and a three-phase AC induction motor, and a microprocessor-based circuit controls the inverter using pulse width modulation techniques. In the disclosed method of pulse width modulation, both edges of each pulse of a carrier pulse train are equally modulated by a time proportional to sin .theta., where .theta. is the angular displacement of the pulse center at the motor stator frequency from a fixed reference point on the carrier waveform. The carrier waveform frequency is a multiple of the motor stator frequency. The modulated pulse train is then applied to each of the motor phase inputs with respective phase shifts of 120.degree. at the stator frequency. Switching control commands for electronic switches in the inverter are stored in a random access memory (RAM) and the locations of the RAM are successively read out in a cyclic manner, each bit of a given RAM location controlling a respective phase input of the motor. The DC power source preferably comprises rechargeable batteries and all but one of the electronic switches in the inverter can be disabled, the remaining electronic switch being part of a flyback DC-DC converter circuit for recharging the battery.

Hyaluronan and hyaluronectin in the extracellular matrix of human brain tumour stroma.

PubMed

Delpech, B; Maingonnat, C; Girard, N; Chauzy, C; Maunoury, R; Olivier, A; Tayot, J; Creissard, P

1993-01-01

Hyaluronan (HA) and the hyaluronan-binding glycoprotein hyaluronectin (HN) were measured in 23 gliomas and 8 meningiomas and their location was revisited in 35 tumours. A clear-cut difference was found in the HN/HA ratio values of glioblastomas (below 0.5) and that of astrocytomas (above 0.5 P < 0.001). Besides their location in the intercellular part of gliomas, HA and HN displayed a perivascular location in 1/3 astrocytomas, 17/24 glioblastomas, and 3/7 meningiomas, suggesting they could be produced also by the vascular stroma of tumours and that they would characterise the neoangiogenesis. All cultivated glioma cells tested produced HA in vitro, whereas only 1/11 cell lines produced HN, at a low level. The results obtained suggest that glioma HA and HN are produced by both cancer cells and vascular stroma cells, which contribute to the edification of the extracellular matrix. In meningiomas only the stroma would be responsible for HA and HN production.

Increasing the information rates of optical communications via coded modulation: a study of transceiver performance

NASA Astrophysics Data System (ADS)

Maher, Robert; Alvarado, Alex; Lavery, Domaniç; Bayvel, Polina

2016-02-01

Optical fibre underpins the global communications infrastructure and has experienced an astonishing evolution over the past four decades, with current commercial systems transmitting data rates in excess of 10 Tb/s over a single fibre core. The continuation of this dramatic growth in throughput has become constrained due to a power dependent nonlinear distortion arising from a phenomenon known as the Kerr effect. The mitigation of fibre nonlinearities is an area of intense research. However, even in the absence of nonlinear distortion, the practical limit on the transmission throughput of a single fibre core is dominated by the finite signal-to-noise ratio (SNR) afforded by current state-of-the-art coherent optical transceivers. Therefore, the key to maximising the number of information bits that can be reliably transmitted over a fibre channel hinges on the simultaneous optimisation of the modulation format and code rate, based on the SNR achieved at the receiver. In this work, we use an information theoretic approach based on the mutual information and the generalised mutual information to characterise a state-of-the-art dual polarisation m-ary quadrature amplitude modulation transceiver and subsequently apply this methodology to a 15-carrier super-channel to achieve the highest throughput (1.125 Tb/s) ever recorded using a single coherent receiver.

Anticipation of guilt for everyday moral transgressions: The role of the anterior insula and the influence of interpersonal psychopathic traits

PubMed Central

Seara-Cardoso, Ana; Sebastian, Catherine L.; McCrory, Eamon; Foulkes, Lucy; Buon, Marine; Roiser, Jonathan P.; Viding, Essi

2016-01-01

Psychopathy is a personality disorder characterised by atypical moral behaviour likely rooted in atypical affective/motivational processing, as opposed to an inability to judge the wrongness of an action. Guilt is a moral emotion believed to play a crucial role in adherence to moral and social norms, but the mechanisms by which guilt (or lack thereof) may influence behaviour in individuals with high levels of psychopathic traits are unclear. We measured neural responses during the anticipation of guilt about committing potential everyday moral transgressions, and tested the extent to which these varied with psychopathic traits. We found a significant interaction between the degree to which anticipated guilt was modulated in the anterior insula and interpersonal psychopathic traits: anterior insula modulation of anticipated guilt was weaker in individuals with higher levels of these traits. Data from a second sample confirmed that this pattern of findings was specific to the modulation of anticipated guilt and not related to the perceived wrongness of the transgression. These results suggest a central role for the anterior insula in coding the anticipation of guilt regarding potential moral transgressions and advance our understanding of the neurocognitive mechanisms that may underlie propensity to antisocial behaviour. PMID:27808160

Increasing the information rates of optical communications via coded modulation: a study of transceiver performance

PubMed Central

Maher, Robert; Alvarado, Alex; Lavery, Domaniç; Bayvel, Polina

2016-01-01

Optical fibre underpins the global communications infrastructure and has experienced an astonishing evolution over the past four decades, with current commercial systems transmitting data rates in excess of 10 Tb/s over a single fibre core. The continuation of this dramatic growth in throughput has become constrained due to a power dependent nonlinear distortion arising from a phenomenon known as the Kerr effect. The mitigation of fibre nonlinearities is an area of intense research. However, even in the absence of nonlinear distortion, the practical limit on the transmission throughput of a single fibre core is dominated by the finite signal-to-noise ratio (SNR) afforded by current state-of-the-art coherent optical transceivers. Therefore, the key to maximising the number of information bits that can be reliably transmitted over a fibre channel hinges on the simultaneous optimisation of the modulation format and code rate, based on the SNR achieved at the receiver. In this work, we use an information theoretic approach based on the mutual information and the generalised mutual information to characterise a state-of-the-art dual polarisation m-ary quadrature amplitude modulation transceiver and subsequently apply this methodology to a 15-carrier super-channel to achieve the highest throughput (1.125 Tb/s) ever recorded using a single coherent receiver. PMID:26864633

Anticipation of guilt for everyday moral transgressions: The role of the anterior insula and the influence of interpersonal psychopathic traits.

PubMed

Seara-Cardoso, Ana; Sebastian, Catherine L; McCrory, Eamon; Foulkes, Lucy; Buon, Marine; Roiser, Jonathan P; Viding, Essi

2016-11-03

Psychopathy is a personality disorder characterised by atypical moral behaviour likely rooted in atypical affective/motivational processing, as opposed to an inability to judge the wrongness of an action. Guilt is a moral emotion believed to play a crucial role in adherence to moral and social norms, but the mechanisms by which guilt (or lack thereof) may influence behaviour in individuals with high levels of psychopathic traits are unclear. We measured neural responses during the anticipation of guilt about committing potential everyday moral transgressions, and tested the extent to which these varied with psychopathic traits. We found a significant interaction between the degree to which anticipated guilt was modulated in the anterior insula and interpersonal psychopathic traits: anterior insula modulation of anticipated guilt was weaker in individuals with higher levels of these traits. Data from a second sample confirmed that this pattern of findings was specific to the modulation of anticipated guilt and not related to the perceived wrongness of the transgression. These results suggest a central role for the anterior insula in coding the anticipation of guilt regarding potential moral transgressions and advance our understanding of the neurocognitive mechanisms that may underlie propensity to antisocial behaviour.

Health Instruction Packages: Venipuncture and Intravenous Therapy.

ERIC Educational Resources Information Center

Gray, P. Allen, Jr.; And Others

Text, illustrations, and exercises are utilized in these five learning modules to instruct nursing students in techniques for initiating intravenous (I.V.) therapy. The first module, "Selection of a Venipuncture Site: Arm" by P. Allen Gray, Jr., describes the utilization of a tourniquet in locating filled veins in the arm. The second…

Software Repository

NASA Technical Reports Server (NTRS)

Merwarth, P., D.

1983-01-01

The Common Software Module Repository (CSMR) is computerized library system with high product and service visibility to potential users. Online capabilities of system allow both librarian and user to interact with library. Librarian is responsible for maintaining information in CSMR library. User searches library to locate software modules that meet his or her current needs.

Ultrasonically enhanced fractionation of milk fat in a litre-scale prototype vessel.

PubMed

Leong, Thomas; Johansson, Linda; Mawson, Raymond; McArthur, Sally L; Manasseh, Richard; Juliano, Pablo

2016-01-01

The ultrasonic fractionation of milk fat in whole milk to fractions with distinct particle size distributions was demonstrated using a stage-based ultrasound-enhanced gravity separation protocol. Firstly, a single stage ultrasound gravity separation was characterised after various sonication durations (5-20 min) with a mass balance, where defined volume partitions were removed across the height of the separation vessel to determine the fat content and size distribution of fat droplets. Subsequent trials using ultrasound-enhanced gravity separation were carried out in three consecutive stages. Each stage consisted of 5 min sonication, with single and dual transducer configurations at 1 MHz and 2 MHz, followed by aliquot collection for particle size characterisation of the formed layers located at the bottom and top of the vessel. After each sonication stage, gentle removal of the separated fat layer located at the top was performed. Results indicated that ultrasound promoted the formation of a gradient of vertically increasing fat concentration and particle size across the height of the separation vessel, which became more pronounced with extended sonication time. Ultrasound-enhanced fractionation provided fat enriched fractions located at the top of the vessel of up to 13 ± 1% (w/v) with larger globules present in the particle size distributions. In contrast, semi-skim milk fractions located at the bottom of the vessel as low as 1.2 ± 0.01% (w/v) could be produced, containing proportionally smaller sized fat globules. Particle size differentiation was enhanced at higher ultrasound energy input (up to 347 W/L). In particular, dual transducer after three-stage operation at maximum energy input provided highest mean particle size differentiation with up to 0.9 μm reduction in the semi-skim fractions. Higher frequency ultrasound at 2 MHz was more effective in manipulating smaller sized fat globules retained in the later stages of skimming than 1 MHz. While 2 MHz ultrasound removed 59 ± 2% of the fat contained in the initial sample, only 47 ± 2% was removed with 1 MHz after 3 ultrasound-assisted fractionation stages. Copyright © 2015 Elsevier B.V. All rights reserved.

Bracket for photovoltaic modules

DOEpatents

Ciasulli, John; Jones, Jason

2014-06-24

Brackets for photovoltaic ("PV") modules are described. In one embodiment, a saddle bracket has a mounting surface to support one or more PV modules over a tube, a gusset coupled to the mounting surface, and a mounting feature coupled to the gusset to couple to the tube. The gusset can have a first leg and a second leg extending at an angle relative to the mounting surface. Saddle brackets can be coupled to a torque tube at predetermined locations. PV modules can be coupled to the saddle brackets. The mounting feature can be coupled to the first gusset and configured to stand the one or more PV modules off the tube.

Microterminal/Microfiche System for Computer-Based Instruction: Hardware and Software Development.

DTIC Science & Technology

1980-10-01

Circuit Description and Schematic of Adaptor Module 57 Appendix C Circuit Description The schematics for circuitry used in the microfiche viewer and the...composed of four major components and associated interfaces. The major components are (a) mirroterminal. (Is) microfiche reader. (0) memory module , and (d...sensing of the position of the platen containing the microfiche so that frame locations can be verified by the microterminal software. The memory module is

iss049e012018

NASA Image and Video Library

2016-09-27

ISS049e012018 (09/27/2016) --- Expedition 49 crewmember Kate Rubins of NASA works with the airlock inside of Kibo, the Japanese Experiment Module. Rubins was installing the Robotics External Leak Locator (RELL), a technology demonstration designed to locate external ISS ammonia (NH3) leaks.

Comparative study of CXC chemokines modulation in brown trout (Salmo trutta) following infection with a bacterial or viral pathogen.

PubMed

Gorgoglione, Bartolomeo; Zahran, Eman; Taylor, Nick G H; Feist, Stephen W; Zou, Jun; Secombes, Christopher J

2016-03-01

Chemokine modulation in response to pathogens still needs to be fully characterised in fish, in view of the recently described novel chemokines present. This paper reports the first comparative study of CXC chemokine genes transcription in salmonids (brown trout), with a particular focus on the fish specific CXC chemokines (CXCL_F). Adopting new primer sets, optimised to specifically target mRNA, a RT-qPCR gene screening was carried out. Constitutive gene expression was assessed first in six tissues from SPF brown trout. Transcription modulation was next investigated in kidney and spleen during septicaemic infection induced by a RNA virus (Viral Haemorrhagic Septicaemia virus, genotype Ia) or by a Gram negative bacterium (Yersinia ruckeri, ser. O1/biot. 2). From each target organ specific pathogen burden, measured detecting VHSV-glycoprotein or Y. ruckeri 16S rRNA, and IFN-γ gene expression were analysed for their correlation to chemokine transcription. Both pathogens modulated CXC chemokine gene transcript levels, with marked up-regulation seen in some cases, and with both temporal and tissue specific effects apparent. For example, Y. ruckeri strongly induced chemokine transcription in spleen within 24h, whilst VHS generally induced the largest increases at 3d.p.i. in both tissues. This study gives clues to the role of the novel CXC chemokines, in comparison to the other known CXC chemokines in salmonids. Copyright © 2016 Elsevier Ltd. All rights reserved.

Detrecting and Locating Partial Discharges in Transformers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shourbaji, A.; Richards, R.; Kisner, R. A.

A collaborative research between the Oak Ridge National Laboratory (ORNL), the American Electric Power (AEP), the Tennessee Valley Authority (TVA), and the State of Ohio Energy Office (OEO) has been formed to conduct a feasibility study to detect and locate partial discharges (PDs) inside large transformers. The success of early detection of the PDs is necessary to avoid costly catastrophic failures that can occur if the process of PD is ignored. The detection method under this research is based on an innovative technology developed by ORNL researchers using optical methods to sense the acoustical energy produced by the PDs. ORNLmore » researchers conducted experimental studies to detect PD using an optical fiber as an acoustic sensor capable of detecting acoustical disturbances at any point along its length. This technical approach also has the potential to locate the point at which the PD was sensed within the transformer. Several optical approaches were experimentally investigated, including interferometric detection of acoustical disturbances along the sensing fiber, light detection and ranging (LIDAR) techniques using frequency modulation continuous wave (FMCW), frequency modulated (FM) laser with a multimode fiber, FM laser with a single mode fiber, and amplitude modulated (AM) laser with a multimode fiber. The implementation of the optical fiber-based acoustic measurement technique would include installing a fiber inside a transformer allowing real-time detection of PDs and determining their locations. The fibers are nonconductive and very small (core plus cladding are diameters of 125 μm for single-mode fibers and 230 μm for multimode fibers). The research identified the capabilities and limitations of using optical technology to detect and locate sources of acoustical disturbances such as in PDs in large transformers. Amplitude modulation techniques showed the most promising results and deserve further research to better quantify the technique’s sensitivity and its ability to characterize a PD event. Other sensing techniques have been also identified, such as the wavelength shifting fiber optics and custom fabricated fibers with special coatings.« less

Comparison of Indo-Pacific humpback dolphin (Sousa chinensis) whistles from two areas of western Peninsular Malaysia.

PubMed

Hoffman, Jordan M; Ponnampalam, Louisa S; Araújo, Claryana C; Wang, John Y; Kuit, Sui Hyang; Hung, Samuel K

2015-11-01

Differences in the acoustic variables of whistles emitted by Indo-Pacific humpback dolphins (Sousa chinensis) from two coastal locations along western Peninsular Malaysia were investigated. Duration, frequency, and frequency modulation variables were extracted from and used to characterize recordings of free-ranging humpback dolphins that were made using a broadband towed hydrophone. A total of 960 whistles from Matang Mangroves and 823 whistles from Langkawi Island were used in analyses. The whistles of Malaysian humpback dolphins covered frequencies from 1231 to 27 120 Hz with durations from 0.010-1.575 s. Significant multivariate differences were found in whistles emitted between locations. Significant differences were also found between dolphins of the two locations in their whistle duration, frequency modulation, and all frequency variables except for minimum frequency, which is likely under morphological constraints. The differences in whistles may be related to adaptations to the local acoustic habitat or unique whistles may have developed due to social interactions within each location, or broader scale differences resulting from geographic separation between the locations.

A Functional Characterisation of a Wide Range of Cover Crop Species: Growth and Nitrogen Acquisition Rates, Leaf Traits and Ecological Strategies

PubMed Central

Tribouillois, Hélène; Fort, Florian; Cruz, Pablo; Charles, Raphaël; Flores, Olivier; Garnier, Eric; Justes, Eric

2015-01-01

Cover crops can produce ecosystem services during the fallow period, as reducing nitrate leaching and producing green manure. Crop growth rate (CGR) and crop nitrogen acquisition rate (CNR) can be used as two indicators of the ability of cover crops to produce these services in agrosystems. We used leaf functional traits to characterise the growth strategies of 36 cover crops as an approach to assess their ability to grow and acquire N rapidly. We measured specific leaf area (SLA), leaf dry matter content (LDMC), leaf nitrogen content (LNC) and leaf area (LA) and we evaluated their relevance to characterise CGR and CNR. Cover crop species were positioned along the Leaf Economics Spectrum (LES), the SLA-LDMC plane, and the CSR triangle of plant strategies. LA was positively correlated with CGR and CNR, while LDMC was negatively correlated with CNR. All cover crops could be classified as resource-acquisitive species from their relative position on the LES and the SLA-LDMC plane. Most cover crops were located along the Competition/Ruderality axis in the CSR triangle. In particular, Brassicaceae species were classified as very competitive, which was consistent with their high CGR and CNR. Leaf functional traits, especially LA and LDMC, allowed to differentiate some cover crops strategies related to their ability to grow and acquire N. LDMC was lower and LNC was higher in cover crop than in wild species, pointing to an efficient acquisitive syndrome in the former, corresponding to the high resource availability found in agrosystems. Combining several leaf traits explained approximately half of the CGR and CNR variances, which might be considered insufficient to precisely characterise and rank cover crop species for agronomic purposes. We hypothesised that may be the consequence of domestication process, which has reduced the range of plant strategies and modified the leaf trait syndrome in cultivated species. PMID:25789485

PV module mounting method and mounting assembly

DOEpatents

Lenox, Carl J.S.; Johnson, Kurt M.

2013-04-23

A method for mounting PV modules to a deck includes selecting PV module layout pattern so that adjacent PV module edges are spaced apart. PV mounting and support assemblies are secured to the deck according to the layout pattern using fasteners extending into the deck. The PV modules are placed on the PV mounting and support assemblies. Retaining elements are located over and secured against the upper peripheral edge surfaces of the PV modules so to secure them to the deck with the peripheral edges of the PV modules spaced apart from the deck. In some examples a PV module mounting assembly, for use on a shingled deck, comprises flashing, a base mountable on the flashing, a deck-penetrating fastener engageable with the base and securable to the deck so to secure the flashing and the base to the shingled deck, and PV module mounting hardware securable to the base.

Affect is a form of cognition: A neurobiological analysis

PubMed Central

Duncan, Seth; Barrett, Lisa Feldman

2008-01-01

In this paper, we suggest that affect meets the traditional definition of “cognition” such that the affect–cognition distinction is phenomenological, rather than ontological. We review how the affect–cognition distinction is not respected in the human brain, and discuss the neural mechanisms by which affect influences sensory processing. As a result of this sensory modulation, affect performs several basic “cognitive” functions. Affect appears to be necessary for normal conscious experience, language fluency, and memory. Finally, we suggest that understanding the differences between affect and cognition will require systematic study of how the phenomenological distinction characterising the two comes about, and why such a distinction is functional. PMID:18509504

Quantification and characterisation of Trichoderma spp. from different ecosystems.

PubMed

Sariah, M; Choo, C W; Zakaria, H; Norihan, M S

2005-01-01

Basal stem rot of oil palm caused by Ganoderma boninense is of major economic importance. Observations of the low incidence of disease due to Ganoderma species in natural stands, suggest that the disease is kept under control by some biological means. Trichoderma spp. are saprophytic fungi with high antagonistic activities against soil-borne pathogens. However, their abundance and distribution are soil and crop specific. Trichoderma species have been found to be concentrated in the A1 (0-30 cm) and Be soil horizons (30-60 cm), although the abundance of Trichoderma was not significantly different between the oil palm and non-oil palm ecosystems. Characterisation of Trichoderma isolates based on cultural, morphological and DNA polymorphism showed that T. harzianum, T. virens, T. koningii and T. longibrachiatum made up 72, 14, 10 and 4% of the total Trichoderma isolates isolated. As Trichoderma species are present in the oil palm ecosystem, but at lower numbers and in locations different from those desired, soil augmentation with antagonistic Trichoderma spp. can be developed as a strategy towards integrated management of basal stem rot of oil palm.

The large-scale ionospheric transient current system response to upstream solar wind IMF Bz north-south and south-north turnings as seen by the WIND satellite and the full SuperMAG network of ground based magnetometers

NASA Astrophysics Data System (ADS)

Dods, Joe; Chapman, Sandra; Gjerloev, Jesper

2017-04-01

We characterise the response of the quiet-time (no substorms or storms) large scale ionospheric convection system to north-south and south-north IMF turnings by using a dynamical network of ground-based magnetometers. Canonical correlation between all pairs of SuperMAG magnetometer stations in the northern hemisphere (MLat 50-82°) is used to establish the extent of near-simultaneous magnetic response between regions of MLT-MLat. Parameters and maps that describe spatial-temporal correlation are used to characterise the system and its response to the turnings aggregated over several hundred events. We find that regions that experience large increases in correlation post-turning coincide with typical locations of a two cell convection system and are influenced by the IMF By. The time between the turnings reaching the magnetopause and a network response is found to be ˜8-10 minutes and correlation in the dayside occurs 2-8 mins before that in the nightside.

Spectral autofluorescence imaging of the retina for drusen detection

NASA Astrophysics Data System (ADS)

Foubister, James J.; Gorman, Alistair; Harvey, Andy; Hemert, Jano van

2018-02-01

The presence and characteristics of drusen in retinal images, namely their size, location, and distribution, can be used to aid in the diagnosis and monitoring of Age Related Macular Degeneration (AMD); one of the leading causes for blindness in the elderly population. Current imaging techniques are effective at determining the presence and number of drusen, but fail when it comes to classifying their size and form. These distinctions are important for correctly characterising the disease, especially in the early stages where the development of just one larger drusen can indicate progression. Another challenge for automated detection is in distinguishing them from other retinal features, such as cotton wool spots. We describe the development of a multi-spectral scanning-laser ophthalmoscope that records images of retinal autofluorescence (AF) in four spectral bands. This will offer the potential to detect drusen with improved contrast based on spectral discrimination for automated classification. The resulting improved specificity and sensitivity for their detection offers more reliable characterisation of AMD. We present proof of principle images prior to further system optimisation and clinical trials for assessment of enhanced detection of drusen.

Optimal configurations of spatial scale for grid cell firing under noise and uncertainty

PubMed Central

Towse, Benjamin W.; Barry, Caswell; Bush, Daniel; Burgess, Neil

2014-01-01

We examined the accuracy with which the location of an agent moving within an environment could be decoded from the simulated firing of systems of grid cells. Grid cells were modelled with Poisson spiking dynamics and organized into multiple ‘modules’ of cells, with firing patterns of similar spatial scale within modules and a wide range of spatial scales across modules. The number of grid cells per module, the spatial scaling factor between modules and the size of the environment were varied. Errors in decoded location can take two forms: small errors of precision and larger errors resulting from ambiguity in decoding periodic firing patterns. With enough cells per module (e.g. eight modules of 100 cells each) grid systems are highly robust to ambiguity errors, even over ranges much larger than the largest grid scale (e.g. over a 500 m range when the maximum grid scale is 264 cm). Results did not depend strongly on the precise organization of scales across modules (geometric, co-prime or random). However, independent spatial noise across modules, which would occur if modules receive independent spatial inputs and might increase with spatial uncertainty, dramatically degrades the performance of the grid system. This effect of spatial uncertainty can be mitigated by uniform expansion of grid scales. Thus, in the realistic regimes simulated here, the optimal overall scale for a grid system represents a trade-off between minimizing spatial uncertainty (requiring large scales) and maximizing precision (requiring small scales). Within this view, the temporary expansion of grid scales observed in novel environments may be an optimal response to increased spatial uncertainty induced by the unfamiliarity of the available spatial cues. PMID:24366144

Low-Speed Flight Dynamic Tests and Analysis of the Orion Crew Module Drogue Parachute System

NASA Technical Reports Server (NTRS)

Hahne, David E.; Fremaux, C. Michael

2008-01-01

A test of a dynamically scaled model of the NASA Orion Crew Module (CM) with drogue parachutes was conducted in the NASA-Langley 20-Foot Vertical Spin Tunnel. The primary test objective was to assess the ability of the Orion Crew Module drogue parachute system to adequately stabilize the CM and reduce angular rates at low subsonic Mach numbers. Two attachment locations were tested: the current design nominal and an alternate. Experimental results indicated that the alternate attachment location showed a somewhat greater tendency to attenuate initial roll rate and reduce roll rate oscillations than the nominal location. Comparison of the experimental data to a Program To Optimize Simulated Trajectories (POST II) simulation of the experiment yielded results for the nominal attachment point that indicate differences between the low-speed pitch and yaw damping derivatives in the aerodynamic database and the physical model. Comparisons for the alternate attachment location indicate that riser twist plays a significant role in determining roll rate attenuation characteristics. Reevaluating the impact of the alternate attachment points using a simulation modified to account for these results showed significantly reduced roll rate attenuation tendencies when compared to the original simulation. Based on this modified simulation the alternate attachment point does not appear to offer a significant increase in allowable roll rate over the nominal configuration.

Forensic analysis of rockfall scars

NASA Astrophysics Data System (ADS)

de Vilder, Saskia J.; Rosser, Nick J.; Brain, Matthew J.

2017-10-01

We characterise and analyse the detachment (scar) surfaces of rockfalls to understand the mechanisms that underpin their failure. Rockfall scars are variously weathered and comprised of both discontinuity release surfaces and surfaces indicative of fracturing through zones of previously intact rock, known as rock bridges. The presence of rock bridges and pre-existing discontinuities is challenging to quantify due to the difficulty in determining discontinuity persistence below the surface of a rock slope. Rock bridges form an important control in holding blocks onto rockslopes, with their frequency, extent and location commonly modelled from the surface exposure of daylighting discontinuities. We explore an alternative approach to assessing their role, by characterising failure scars. We analyse a database of multiple rockfall scar surfaces detailing the areal extent, shape, and location of broken rock bridges and weathered surfaces. Terrestrial laser scanning and gigapixel imagery were combined to record the detailed texture and surface morphology. From this, scar surfaces were mapped via automated classification based on RGB pixel values. Our analysis of the resulting data from scars on the North Yorkshire coast (UK) indicates a wide variation in both weathering and rock bridge properties, controlled by lithology and associated rock mass structure. Importantly, the proportion of rock bridges in a rockfall failure surface does not increase with failure size. Rather larger failures display fracturing through multiple rock bridges, and in contrast smaller failures fracture occurs only through a single critical rock bridge. This holds implications for how failure mechanisms change with rockfall size and shape. Additionally, the location of rock bridges with respect to the geometry of an incipient rockfall is shown to determine failure mode. Weathering can occur both along discontinuity surfaces and previously broken rock bridges, indicating the sequential stages of progressively detaching rockfall. Our findings have wider implications for hazard assessment where rock slope stability is dependent on the nature of rock bridges, how this is accounted for in slope stability modelling, and the implications of rock bridges on long-term rock slope evolution.

Active stress along the ne external margin of the Apennines: the Ferrara arc, northern Italy

NASA Astrophysics Data System (ADS)

Montone, Paola; Mariucci, M. Teresa

1999-09-01

We have analysed borehole breakout data from 12 deep wells in order to constrain the direction of the minimum and maximum horizontal stress in a part of the Po Plain, northern Italy, characterised by a ˜N-S prevailing compressional stress regime, and in order to shed light on the regional state of stress and on the correlation between the active stress field and the orientation of tectonic structures. The results have been compared with seismological data relating to 1988-1995 crustal seismicity (2.5< Md<4.8) and to the 1983 Parma ( Ms=5.0) and the 1996 Reggio Emilia ( Ms=5.1) events. Plio-Pleistocene mesostructural data are also described in order to better define the present-day stress field and to understand the active tectonic processes in particular stress provinces. The borehole breakout analysis, in accordance with the seismicity and mesostructural data, shows the presence of a predominant compression area, characterised by approximately N-S maximum horizontal stress, along the outer thrust of the Ferrara arc. Particularly, the breakout analysis indicates a minimum horizontal stress, N81W±22° relative to a total of eleven analysed wells, with 3746 m cumulative total length of breakout zones. Among these, nine wells are located in the same tectonic structure, consisting of an arc of asymmetric folds overthrust towards the NE. The breakout results for these wells are quite similar in terms of minimum horizontal stress direction (˜E-W oriented). The other two wells are located in the outside sector of the arc and one of them shows a different minimum horizontal stress direction, probably distinctive of another tectonic unit. On the basis of these new reliable stress indicators, the active compressive front in this area is located along the termination of the external northern Apenninic arc.

A decade of passive seismic monitoring experiments with local networks in four Italian regions

NASA Astrophysics Data System (ADS)

Chiaraluce, L.; Valoroso, L.; Anselmi, M.; Bagh, S.; Chiarabba, C.

2009-10-01

We report on four seismic monitoring experiments that in the past ten years we carried out with dense local networks in seismically active Italian areas where for at least a year, tens of three component seismic stations were set up to record microseismicity. The areas observed are Alpago-Cansiglio, located in the Venetian Alps, Città di Castello in the Northern Apennines, Marsica in the Central Apennines and Val d'Agri located in the Southern Apennines. We produced homogeneous catalogues regarding earthquake locations and local magnitudes to investigate seismicity patterns during an inter-seismic period. The four regions are characterised by different kinematics, strain rates and historical/recent seismicity. We investigate earthquake distribution in space, time and size obtaining reference seismic rates and parameters of the Gutenberg and Richter law. We declustered the catalogues to look for coherent signs in the background seismic activity. Despite a difference in the catalogues magnitudes of completeness due both to the diverse detection threshold of the local networks and different seismic release, we detect and observe two common main behaviours: a) The Alpago-Cansiglio and Marsica regions are characterised by a relatively lower rate of seismic release associated to the episodic occurrence of seismic sequences with the largest event being 3 < ML < 4. In these areas the seismicity is not localised around the main faults. b) The Città di Castello and Val d'Agri regions have a relatively high rate of seismicity release almost continuously with time, and the increase in earthquake production is not clearly related to seismic sequences. In these areas the seismicity nucleates around defined fault systems and is usually lower than ML < 3. We suggest that the presence of over-pressured fluids in the Città di Castello and Val d'Agri uppermost crustal volume may favour and mould the higher rate of microseismic release.

Qualification testing of flat-plate photovoltaic modules

NASA Technical Reports Server (NTRS)

Hoffman, A. R.; Griffith, J. S.; Ross, R. G., Jr.

1982-01-01

The placement of photovoltaic modules in various applications, in climates and locations throughout the world, results in different degrees and combinations of environmental and electrical stress. Early detection of module reliability deficiencies via laboratory testing is necessary for achieving long, satisfactory field service. This overview paper describes qualification testing techniques being used in the US Department of Energy's flat-plate terrestrial photovoltaic development program in terms of their significance, rationale for specified levels and durations, and test results.

Long period seismic noise modulated by atmospheric tides

NASA Astrophysics Data System (ADS)

Custódio, Susana; Helffrich, George

2016-04-01

The amplitudes of long-period (LP) seismic noise often exhibit a daily modulation, which is particularly visible on data recorded by temporary stations and horizontal components. These daily variations of the LP noise have been associated with temperature fluctuations. Temperature has been suggested to affect the noise recorded by seismometers by means of thermal convection around the sensor or by causing thermally induced tilts. Recently, we observed a semi-diurnal (12.0 hr) modulation of LP seismic noise amplitudes in seismometers in Portugal, SW Europe. This modulation was associated with the variation of atmospheric pressure, the only environmental signal to display a dominant 12-hr periodicity (at some locations). In this presentation we will present an analysis of this semi-diurnal modulation of long-period seismic noise. We show that the modulation: 1) is not instrument dependent, being recorded in a variety of sensors; 2) is observed in stations in mainland Portugal, Madeira island (N Atlantic), Florida (USA) and Mozambique, where it is strongest; 3) is seen only at a minority of sites without a clear geographical association, thus appearing to be strongly site-dependent; 5) is stronger during the Summer than during the Winter; and 6) is more clearly seen on vertical components. We will use data from the Transportable Array (EarthScope, USA) to investigate the admittance between LP seismic noise variations and co-located atmospheric pressure measurements.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Horowitz, Kelsey A. W.; Fu, Ran; Woodhouse, Michael

This article examines current cost drivers and potential avenues to reduced cost for monolithic, glass-glass Cu(In,Ga)(Se,S)2 (CIGS) modules by constructing a comprehensive bottom-up cost model. For a reference case where sputtering plus batch sulfurization after selenization (SAS) is employed, we compute a manufacturing cost of $69/m2 if the modules are made in the United States at a 1 GW/year production volume. At 14% module efficiency, this corresponds to a manufacturing cost of $0.49/WDC and a minimum sustainable price (MSP) of $0.67/WDC. We estimate that MSP could vary within +/-20% of this value given the range of quoted input prices, andmore » existing variations in module design, manufacturing processes, and manufacturing location. Potential for reduction in manufacturing costs to below $0.40/WDC may be possible if average production module efficiencies can be increased above 17% without increasing $/m2 costs; even lower costs could be achieved if $/m2 costs could be reduced, particularly via innovations in the CIGS deposition process or balance-of-module elements. We present the impact on cost of regional factors, CIGS deposition method, device design, and price fluctuations. One metric of competitiveness-levelized cost of energy (LCOE) -- is also assessed for several U.S. locations and compared to that of standard multi-crystalline silicon (m(c-Si)) and cadmium telluride (CdTe).« less

FTIR microspectroscopy for rapid screening and monitoring of polyunsaturated fatty acid production in commercially valuable marine yeasts and protists.

PubMed

Vongsvivut, Jitraporn; Heraud, Philip; Gupta, Adarsha; Puri, Munish; McNaughton, Don; Barrow, Colin J

2013-10-21

The increase in polyunsaturated fatty acid (PUFA) consumption has prompted research into alternative resources other than fish oil. In this study, a new approach based on focal-plane-array Fourier transform infrared (FPA-FTIR) microspectroscopy and multivariate data analysis was developed for the characterisation of some marine microorganisms. Cell and lipid compositions in lipid-rich marine yeasts collected from the Australian coast were characterised in comparison to a commercially available PUFA-producing marine fungoid protist, thraustochytrid. Multivariate classification methods provided good discriminative accuracy evidenced from (i) separation of the yeasts from thraustochytrids and distinct spectral clusters among the yeasts that conformed well to their biological identities, and (ii) correct classification of yeasts from a totally independent set using cross-validation testing. The findings further indicated additional capability of the developed FPA-FTIR methodology, when combined with partial least squares regression (PLSR) analysis, for rapid monitoring of lipid production in one of the yeasts during the growth period, which was achieved at a high accuracy compared to the results obtained from the traditional lipid analysis based on gas chromatography. The developed FTIR-based approach when coupled to programmable withdrawal devices and a cytocentrifugation module would have strong potential as a novel online monitoring technology suited for bioprocessing applications and large-scale production.

Host defence related responses in bovine milk during an experimentally induced Streptococcus uberis infection

PubMed Central

2014-01-01

Background Milk contains a range of proteins of moderate or low abundance that contribute to host defence. Characterisation of these proteins, the extent to which their abundance is regulated by pathogenic stimuli, and the variability of their response between and within individual animals would facilitate a better understanding of the molecular basis for this important function of milk. Results We have characterised the host defence proteins in bovine milk and their responses to intra-mammary infection by a common Gram positive mastitis pathogen, Streptococcus uberis, using a combination of 2D gel electrophoresis and GeLC mass spectrometry. In total, 68 host defence-associated proteins were identified, 18 of which have a direct antimicrobial function, 23 of which have a pathogen-recognition function, and 27 of which have a role in modulating inflammatory or immune signalling. The responsiveness of seven proteins was quantified by western blotting; validating the proteomic analyses, quantifying the within- and between animal variability of the responses, and demonstrating the complexity and specificity of the responses to this pathogen. Conclusions These data provide a foundation for understanding the role of milk in host-microbe interaction. Furthermore they provide candidate biomarkers for mastitis diagnosis, and will inform efforts to develop dairy products with improved health-promoting properties. PMID:24721702

Functional conservation between rodents and chicken of regulatory sequences driving skeletal muscle gene expression in transgenic chickens

PubMed Central

2010-01-01

Background Regulatory elements that control expression of specific genes during development have been shown in many cases to contain functionally-conserved modules that can be transferred between species and direct gene expression in a comparable developmental pattern. An example of such a module has been identified at the rat myosin light chain (MLC) 1/3 locus, which has been well characterised in transgenic mouse studies. This locus contains two promoters encoding two alternatively spliced isoforms of alkali myosin light chain. These promoters are differentially regulated during development through the activity of two enhancer elements. The MLC3 promoter alone has been shown to confer expression of a reporter gene in skeletal and cardiac muscle in transgenic mice and the addition of the downstream MLC enhancer increased expression levels in skeletal muscle. We asked whether this regulatory module, sufficient for striated muscle gene expression in the mouse, would drive expression in similar domains in the chicken. Results We have observed that a conserved downstream MLC enhancer is present in the chicken MLC locus. We found that the rat MLC1/3 regulatory elements were transcriptionally active in chick skeletal muscle primary cultures. We observed that a single copy lentiviral insert containing this regulatory cassette was able to drive expression of a lacZ reporter gene in the fast-fibres of skeletal muscle in chicken in three independent transgenic chicken lines in a pattern similar to the endogenous MLC locus. Reporter gene expression in cardiac muscle tissues was not observed for any of these lines. Conclusions From these results we conclude that skeletal expression from this regulatory module is conserved in a genomic context between rodents and chickens. This transgenic module will be useful in future investigations of muscle development in avian species. PMID:20184756

LSM I: Library Skills Module for English 131.

ERIC Educational Resources Information Center

Wright, Nancy Kirkpatrick

This learning module provides 11 lessons to acquaint English Composition I students at Yavapai College (YC) with the facilities and resources of the YC Library. After introductory material describing course requirements, providing instructions, and locating the campuses' libraries, Lesson I explains how to check out a book, put a book on hold, and…

Modulation of Neck Intermuscular Beta Coherence during Voice and Speech Production

ERIC Educational Resources Information Center

Stepp, Cara E.; Hillman, Robert E.; Heaton, James T.

2011-01-01

Purpose: The purpose of this study was to better understand neck intermuscular beta coherence (15-35 Hz; NIBcoh) in healthy individuals, with respect to modulation by behavioral tasks. Method: Mean NIBcoh was measured using surface electromyography at 2 anterior neck locations in 10 individuals during normal speech, static nonspeech maneuvers,…

AUTOMOTIVE DIESEL MAINTENANCE 1. UNIT VI, MAINTAINING MECHANICAL GOVERNORS--DETROIT DIESEL ENGINES.

ERIC Educational Resources Information Center

Human Engineering Inst., Cleveland, OH.

THIS MODULE OF A 30-MODULE COURSE IS DESIGNED TO DEVELOP AN UNDERSTANDING OF THE OPERATION AND MAINTENANCE OF MECHANICAL GOVERNORS USED ON DIESEL ENGINES. TOPICS ARE (1) TYPES OF GOVERNORS AND ENGINE LOCATION, (2) GOVERNOR APPLICATIONS, (3) LIMITING SPEED MECHANICAL GOVERNOR, (4) VARIABLE SPEED MECHANICAL GOVERNOR, AND (5) CONSTANT SPEED…

Mathematics in Baseball. Topical Module for Use in a Mathematics Laboratory Setting.

ERIC Educational Resources Information Center

Stitt, Mary; Ostrom, Nat

The objectives of this module include: (1) improving general arithmetic skills including whole numbers, fractions, and decimal fractions; (2) learning to compute averages; (3) strengthening knowledge of percent; (4) learning to locate needed information or statistical data; (5) reviewing or learning the use of the Pythagorean Theorem; (6)…

C-Terminal carbohydrate-binding module 9_2 fused to the N-terminus of GH11 xylanase from Aspergillus niger.

PubMed

Xu, Wenxuan; Liu, Yajuan; Ye, Yanxin; Liu, Meng; Han, Laichuang; Song, Andong; Liu, Liangwei

2016-10-01

The 9_2 carbohydrate-binding module (C2) locates natively at the C-terminus of the GH10 thermophilic xylanase from Thermotoga marimita. When fused to the C-terminus, C2 improved thermostability of a GH11 xylanase (Xyn) from Aspergillus niger. However, a question is whether the C-terminal C2 would have a thermostabilizing effect when fused to the N-terminus of a catalytic module. A chimeric enzyme, C2-Xyn, was created by step-extension PCR, cloned in pET21a(+), and expressed in E. coli BL21(DE3). The C2-Xyn exhibited a 2 °C higher optimal temperature, a 2.8-fold longer thermostability, and a 4.5-fold higher catalytic efficiency on beechwood xylan than the Xyn. The C2-Xyn exhibited a similar affinity for binding to beechwood xylan and a higher affinity for oat-spelt xylan than Xyn. C2 is a thermostabilizing carbohydrate-binding module and provides a model of fusion at an enzymatic terminus inconsistent with the modular natural terminal location.

Objects but not concepts modulate the size of the attended region.

PubMed

Goodhew, Stephanie C; Edwards, Mark

2017-07-01

Here we investigated the types of stimuli that modulate the size of the attentional spotlight. In particular, it has been previously shown that conceptual cues that either directly refer to or are semantically related to particular spatial locations can shift attention to that location (known as "conceptual cueing"). For example, reading the word sun or joy can shift attention upward whereas the word boot or hostile can shift attention downward. Here, therefore, we tested whether words could modulate the size of the attended area. Across five experiments, we found that words that either directly referred to, or were abstractly associated with, particular sizes (small versus large) did not change the size of the attentional spotlight, whereas the presence of differently sized stimuli did, as evidenced by faster responses to targets when the spotlight is small than when it is large. This suggests that physical but not conceptual inducers can modulate the size of the attentional spotlight. This highlights an important difference between the regulation of spotlight size and shifts of attention, supporting the notion that they are subserved by distinct mechanisms.

Temporally selective attention modulates early perceptual processing: event-related potential evidence.

PubMed

Sanders, Lisa D; Astheimer, Lori B

2008-05-01

Some of the most important information we encounter changes so rapidly that our perceptual systems cannot process all of it in detail. Spatially selective attention is critical for perception when more information than can be processed in detail is presented simultaneously at distinct locations. When presented with complex, rapidly changing information, listeners may need to selectively attend to specific times rather than to locations. We present evidence that listeners can direct selective attention to time points that differ by as little as 500 msec, and that doing so improves target detection, affects baseline neural activity preceding stimulus presentation, and modulates auditory evoked potentials at a perceptually early stage. These data demonstrate that attentional modulation of early perceptual processing is temporally precise and that listeners can flexibly allocate temporally selective attention over short intervals, making it a viable mechanism for preferentially processing the most relevant segments in rapidly changing streams.

Optimal design and operation of a photovoltaic-electrolyser system using particle swarm optimisation

NASA Astrophysics Data System (ADS)

Sayedin, Farid; Maroufmashat, Azadeh; Roshandel, Ramin; Khavas, Sourena Sattari

2016-07-01

In this study, hydrogen generation is maximised by optimising the size and the operating conditions of an electrolyser (EL) directly connected to a photovoltaic (PV) module at different irradiance. Due to the variations of maximum power points of the PV module during a year and the complexity of the system, a nonlinear approach is considered. A mathematical model has been developed to determine the performance of the PV/EL system. The optimisation methodology presented here is based on the particle swarm optimisation algorithm. By this method, for the given number of PV modules, the optimal sizeand operating condition of a PV/EL system areachieved. The approach can be applied for different sizes of PV systems, various ambient temperatures and different locations with various climaticconditions. The results show that for the given location and the PV system, the energy transfer efficiency of PV/EL system can reach up to 97.83%.

The NavTrax fleet management system

NASA Astrophysics Data System (ADS)

McLellan, James F.; Krakiwsky, Edward J.; Schleppe, John B.; Knapp, Paul L.

The NavTrax System, a dispatch-type automatic vehicle location and navigation system, is discussed. Attention is given to its positioning, communication, digital mapping, and dispatch center components. The positioning module is a robust GPS (Global Positioning System)-based system integrated with dead reckoning devices by a decentralized-federated filter, making the module fault tolerant. The error behavior and characteristics of GPS, rate gyro, compass, and odometer sensors are discussed. The communications module, as presently configured, utilizes UHF radio technology, and plans are being made to employ a digital cellular telephone system. Polling and automatic smart vehicle reporting are also discussed. The digital mapping component is an intelligent digital single line road network database stored in vector form with full connectivity and address ranges. A limited form of map matching is performed for the purposes of positioning, but its main purpose is to define location once position is determined.

High resolution PET breast imager with improved detection efficiency

DOEpatents

Majewski, Stanislaw

2010-06-08

A highly efficient PET breast imager for detecting lesions in the entire breast including those located close to the patient's chest wall. The breast imager includes a ring of imaging modules surrounding the imaged breast. Each imaging module includes a slant imaging light guide inserted between a gamma radiation sensor and a photodetector. The slant light guide permits the gamma radiation sensors to be placed in close proximity to the skin of the chest wall thereby extending the sensitive region of the imager to the base of the breast. Several types of photodetectors are proposed for use in the detector modules, with compact silicon photomultipliers as the preferred choice, due to its high compactness. The geometry of the detector heads and the arrangement of the detector ring significantly reduce dead regions thereby improving detection efficiency for lesions located close to the chest wall.

Emotion modulates activity in the 'what' but not 'where' auditory processing pathway.

PubMed

Kryklywy, James H; Macpherson, Ewan A; Greening, Steven G; Mitchell, Derek G V

2013-11-15

Auditory cortices can be separated into dissociable processing pathways similar to those observed in the visual domain. Emotional stimuli elicit enhanced neural activation within sensory cortices when compared to neutral stimuli. This effect is particularly notable in the ventral visual stream. Little is known, however, about how emotion interacts with dorsal processing streams, and essentially nothing is known about the impact of emotion on auditory stimulus localization. In the current study, we used fMRI in concert with individualized auditory virtual environments to investigate the effect of emotion during an auditory stimulus localization task. Surprisingly, participants were significantly slower to localize emotional relative to neutral sounds. A separate localizer scan was performed to isolate neural regions sensitive to stimulus location independent of emotion. When applied to the main experimental task, a significant main effect of location, but not emotion, was found in this ROI. A whole-brain analysis of the data revealed that posterior-medial regions of auditory cortex were modulated by sound location; however, additional anterior-lateral areas of auditory cortex demonstrated enhanced neural activity to emotional compared to neutral stimuli. The latter region resembled areas described in dual pathway models of auditory processing as the 'what' processing stream, prompting a follow-up task to generate an identity-sensitive ROI (the 'what' pathway) independent of location and emotion. Within this region, significant main effects of location and emotion were identified, as well as a significant interaction. These results suggest that emotion modulates activity in the 'what,' but not the 'where,' auditory processing pathway. Copyright © 2013 Elsevier Inc. All rights reserved.

Orion Crew Module Move

NASA Image and Video Library

2017-11-17

A crane is being prepared for use during move operations of the Orion crew module for Exploration Mission-1 to the thermal chamber in the Neil Armstrong Operations and Checkout Building high bay at NASA's Kennedy Space Center in Florida. The crew module will undergo a thermal cycle test to assess the workmanship of critical hardware and structural locations. The test also demonstrates crew module subsystem operations in a thermally stressing environment to confirm no damage or anomalous hardware conditions as a result of the test. The Orion spacecraft will launch atop NASA's Space Launch System rocket on its first uncrewed integrated flight.

Orion Crew Module Move

NASA Image and Video Library

2017-11-17

Technicians check a crane that will be used during move operations of the Orion crew module for Exploration Mission-1 to the thermal chamber in the Neil Armstrong Operations and Checkout Building high bay at NASA's Kennedy Space Center in Florida. The crew module will undergo a thermal cycle test to assess the workmanship of critical hardware and structural locations. The test also demonstrates crew module subsystem operations in a thermally stressing environment to confirm no damage or anomalous hardware conditions as a result of the test. The Orion spacecraft will launch atop NASA's Space Launch System rocket on its first uncrewed integrated flight.

Orion Crew Module Move

NASA Image and Video Library

2017-11-17

Technicians prepare a crane for use during move operations of the Orion crew module for Exploration Mission-1 to the thermal chamber in the Neil Armstrong Operations and Checkout Building high bay at NASA's Kennedy Space Center in Florida. The crew module will undergo a thermal cycle test to assess the workmanship of critical hardware and structural locations. The test also demonstrates crew module subsystem operations in a thermally stressing environment to confirm no damage or anomalous hardware conditions as a result of the test. The Orion spacecraft will launch atop NASA's Space Launch System rocket on its first uncrewed integrated flight.

Design and demonstration of an advanced data collection/position location system

NASA Technical Reports Server (NTRS)

1977-01-01

The final report on a breadboard evaluation and demonstration program is reported concerning the applicability of MSK modulation and chirp-z transformer technology in Advanced Data Collection/Position Location (ADC/PL) systems. The program effort consisted of three phases - design, testing, and evaluation. Section 2 describes the breadboard hardware built during the design phase of the program, Section 3 describes the tests conducted on the breadboard and the results of the tests, and Section 4 presents a brief analysis and summary of the findings of the breadboard tests and develops a sample ADC/PL system which incorporates both MSK modulation and a chirp-z transformer.

Ultra-Wideband Chaos Life-Detection Radar with Sinusoidal Wave Modulation

NASA Astrophysics Data System (ADS)

Xu, Hang; Li, Ying; Zhang, Jianguo; Han, Hong; Zhang, Bing; Wang, Longsheng; Wang, Yuncai; Wang, Anbang

2017-12-01

We propose and experimentally demonstrate an ultra-wideband (UWB) chaos life-detection radar. The proposed radar transmits a wideband chaotic-pulse-position modulation (CPPM) signal modulated by a single-tone sinusoidal wave. A narrow-band split ring sensor is used to collect the reflected sinusoidal wave, and a lock-in amplifier is utilized to identify frequencies of respiration and heartbeat by detecting the phase change of the sinusoidal echo signal. Meanwhile, human location is realized by correlating the CPPM echo signal with its delayed duplicate and combining the synthetic aperture technology. Experimental results demonstrate that the human target can be located accurately and his vital signs can be detected in a large dynamic range through a 20-cm-thick wall using our radar system. The down-range resolution is 15cm, benefiting from the 1-GHz bandwidth of the CPPM signal. The dynamic range for human location is 50dB, and the dynamic ranges for heartbeat and respiration detection respectively are 20dB and 60dB in our radar system. In addition, the bandwidth of the CPPM signal can be adjusted from 620MHz to 1.56GHz to adapt to different requirements.

Phase-Array Approach to Optical Whispering Gallery Modulators

NASA Technical Reports Server (NTRS)

Strekalov, Dmitry

2010-01-01

This technology leverages the well-defined orbital number of a whispering gallery modulator (WGM) to expand the range of applications for such resonators. This property rigidly connects the phase variation of the field in this mode with the azimuthal angle between the coupling locations. A WGM with orbital momentum L has exactly L instant nodes around the circumference of the WGM resonator supporting such a mode. Therefore, in two locations separated by the arc alpha, the phase difference of such a field will be equal to phi= alpha L. Coupling the field out of such locations, and into a balanced interferometer, once can observe a complete constructive or distractive interference (or have any situation in between) depending on the angle alpha. Similarly, a mode L + delta L will pick up the phase phi + alpha delta L. In all applications of a WGM resonator as a modulator, the orbital numbers for the carrier and sidebands are different, and their differences delta L are known (usually, but not necessarily, delta L = 1). Therefore, the choice of the angle alpha, and of the interferometer arms difference, allows one to control the relative phase between different modes and to perform the conversion, separation, and filtering tasks necessary.

STS-96 crew takes part in payload Interface Verification Test

NASA Technical Reports Server (NTRS)

1999-01-01

At the SPACEHAB Facility, STS-96 Mission Specialist Ellen Ochoa and Commander Kent Rominger pause during a payload Interface Verification Test (IVT) for their upcoming mission to the International Space Station. Other crew members at KSC for the IVT are Pilot Rick Husband and Mission Specialists Tamara Jernigan, Dan Barry, Julie Payette and Valery Tokarev of Russia. Mission STS-96 carries the SPACEHAB Logistics Double Module, which will have equipment to further outfit the International Space Station service module and equipment that can be off-loaded from the early U.S. assembly flights. It carries internal logistics and resupply cargo for station outfitting, plus an external Russian cargo crane to be mounted to the exterior of the Russian station segment and used to perform space walking maintenance activities. The double module stowage provides capacity of up to 10,000 lbs. with the ability to accommodate powered payloads, four external rooftop stowage locations, four double-rack locations (two powered), up to 61 bulkhead-mounted middeck locker locations, and floor storage for large unique items and Soft Stowage. STS-96 is targeted to launch May 20 about 9:32 a.m. EDT.

STS-96 crew takes part in payload Interface Verification Test

NASA Technical Reports Server (NTRS)

1999-01-01

In the SPACEHAB Facility, STS-96 Mission Specialist Julie Payette closes a container, part of the equipment to be carried on the SPACEHAB and mission STS-96. She and other crew members Commander Kent Rominger, Pilot Rick Husband, and Mission Speciaists Ellen Ochoa, Tamara Jernigan, Dan Barry and Valery Tokarev of Russia are at KSC for a payload Interface Verification Test for the upcoming mission to the International Space Station . Mission STS-96 carries the SPACEHAB Logistics Double Module, which has equipment to further outfit the International Space Station service module and equipment that can be off-loaded from the early U.S. assembly flights. The SPACEHAB carries internal logistics and resupply cargo for station outfitting, plus an external Russian cargo crane to be mounted to the exterior of the Russian station segment and used to perform space walking maintenance activities. The double module stowage provides capacity of up to 10,000 lbs. with the ability to accommodate powered payloads, four external rooftop stowage locations, four double-rack locations (two powered), up to 61 bulkhead-mounted middeck locker locations, and floor storage for large unique items and Soft Stowage. STS-96 is targeted to launch May 20 about 9:32 a.m.

STS-96 crew takes part in payload Interface Verification Test

NASA Technical Reports Server (NTRS)

1999-01-01

At the SPACEHAB Facility, STS-96 Mission Specialist Ellen Ochoa and Commander Kent Rominger smile for the camera during a payload Interface Verification Test (IVT) for their upcoming mission to the International Space Station. Other crew members at KSC for the IVT are Pilot Rick Husband and Mission Specialists Tamara Jernigan, Dan Barry, Julie Payette and Valery Tokarev of Russia. Mission STS-96 carries the SPACEHAB Logistics Double Module, which will have equipment to further outfit the International Space Station service module and equipment that can be off-loaded from the early U.S. assembly flights. It carries internal logistics and resupply cargo for station outfitting, plus an external Russian cargo crane to be mounted to the exterior of the Russian station segment and used to perform space walking maintenance activities. The double module stowage provides capacity of up to 10,000 lbs. with the ability to accommodate powered payloads, four external rooftop stowage locations, four double-rack locations (two powered), up to 61 bulkhead-mounted middeck locker locations, and floor storage for large unique items and Soft Stowage. STS-96 is targeted to launch May 20 about 9:32 a.m. EDT.

STS-96 crew takes part in payload Interface Verification Test

NASA Technical Reports Server (NTRS)

1999-01-01

In the SPACEHAB Facility, STS-96 Mission Specialists Dan Barry and Tamara Jernigan discuss procedures during a payload Interface Verification Test (IVT) for their upcoming mission to the International Space Station. Other STS-96 crew members at KSC for the IVT are Commander Kent Rominger, Pilot Rick Husband and Mission Specialists Ellen Ochoa, Julie Payette and Valery Tokarev of Russia. Mission STS-96 carries the SPACEHAB Logistics Double Module, which will have equipment to further outfit the International Space Station service module and equipment that can be off-loaded from the early U.S. assembly flights. It carries internal logistics and resupply cargo for station outfitting, plus an external Russian cargo crane to be mounted to the exterior of the Russian station segment and used to perform space walking maintenance activities. The double module stowage provides capacity of up to 10,000 lbs. with the ability to accommodate powered payloads, four external rooftop stowage locations, four double-rack locations (two powered), up to 61 bulkhead-mounted middeck locker locations, and floor storage for large unique items and Soft Stowage. STS-96 is targeted to launch May 20 about 9:32 a.m.

STS-96 crew takes part in payload Interface Verification Test

NASA Technical Reports Server (NTRS)

1999-01-01

In the SPACEHAB Facility, James Behling, with Boeing, talks about equipment for mission STS-96 during a payload Interface Verification Test (IVT). Watching are (from left) Mission Specialists Ellen Ochoa, Julie Payette and Dan Berry, and Pilot Rick Husband. Other STS-96 crew members at KSC for the IVT are Commander Kent Rominger and Mission Specialists Tamara Jernigan and Valery Tokarev of Russia. Mission STS-96 carries the SPACEHAB Logistics Double Module, which will have equipment to further outfit the International Space Station service module and equipment that can be off-loaded from the early U.S. assembly flights. It carries internal logistics and resupply cargo for station outfitting, plus an external Russian cargo crane to be mounted to the exterior of the Russian station segment and used to perform space walking maintenance activities. The double module stowage provides capacity of up to 10,000 lbs. with the ability to accommodate powered payloads, four external rooftop stowage locations, four double-rack locations (two powered), up to 61 bulkhead-mounted middeck locker locations, and floor storage for large unique items and Soft Stowage. STS-96 is targeted to launch May 20 about 9:32 a.m.

STS-96 crew takes part in payload Interface Verification Test

NASA Technical Reports Server (NTRS)

1999-01-01

During a payload Interface Verification Test (IVT) for their upcoming mission to the International Space Station, STS-96 Mission Specialists Julie Payette, Dan Barry, and Valery Tokarev of Russia, look at a Sequential Shunt Unit in the SPACEHAB Facility. Other crew members at KSC for the IVT are Commander Kent Rominger, Pilot Rick Husband, and Mission Specialists Ellen Ochoa and Tamara Jernigan. Mission STS-96 carries the SPACEHAB Logistics Double Module, which will have equipment to further outfit the International Space Station service module and equipment that can be off-loaded from the early U.S. assembly flights. It carries internal logistics and resupply cargo for station outfitting, plus an external Russian cargo crane to be mounted to the exterior of the Russian station segment and used to perform space walking maintenance activities. The double module stowage provides capacity of up to 10,000 lbs. with the ability to accommodate powered payloads, four external rooftop stowage locations, four double-rack locations (two powered), up to 61 bulkhead-mounted middeck locker locations, and floor storage for large unique items and Soft Stowage. STS-96 is targeted to launch May 20 about 9:32 a.m. EDT.

STS-96 crew takes part in payload Interface Verification Test

NASA Technical Reports Server (NTRS)

1999-01-01

In the SPACEHAB Facility for a payload Interface Verification Test (IVT) for their upcoming mission to the International Space Station are (left to right) Mission Specialists Valery Tokarev, Julie Payette (holding a lithium hydroxide canister) and Dan Barry. Other crew members at KSC for the IVT are Commander Kent Rominger, Pilot Rick Husband and Mission Specialists Ellen Ochoa and Tamara Jernigan. Mission STS-96 carries the SPACEHAB Logistics Double Module, which has equipment to further outfit the International Space Station service module and equipment that can be off-loaded from the early U.S. assembly flights. The SPACEHAB carries internal logistics and resupply cargo for station outfitting, plus an external Russian cargo crane to be mounted to the exterior of the Russian station segment and used to perform space walking maintenance activities. The double module stowage provides capacity of up to 10,000 lbs. with the ability to accommodate powered payloads, four external rooftop stowage locations, four double-rack locations (two powered), up to 61 bulkhead-mounted middeck locker locations, and floor storage for large unique items and Soft Stowage. STS-96 is targeted to launch May 20 about 9:32 a.m.

STS-96 crew takes part in payload Interface Verification Test

NASA Technical Reports Server (NTRS)

1999-01-01

In the SPACEHAB Facility, the STS-96 crew looks over equipment during a payload Interface Verification Test for the upcoming mission to the International Space Station. From left are Commander Kent Rominger, Mission Specialists Tamara Jernigan and Valery Tokarev of Russia, Pilot Rick Husband, and Mission Specialists Ellen Ochoa and Julie Payette (backs to the camera). They are listening to Chris Jaskolka of Boeing talk about the equipment. Mission STS-96 carries the SPACEHAB Logistics Double Module, which will have equipment to further outfit the International Space Station service module and equipment that can be off-loaded from the early U.S. assembly flights. It carries internal logistics and resupply cargo for station outfitting, plus an external Russian cargo crane to be mounted to the exterior of the Russian station segment and used to perform space walking maintenance activities. The double module stowage provides capacity of up to 10,000 lbs. with the ability to accommodate powered payloads, four external rooftop stowage locations, four double-rack locations (two powered), up to 61 bulkhead-mounted middeck locker locations, and floor storage for large unique items and Soft Stowage. STS-96 is targeted to launch May 20 about 9:32 a.m. EDT.

KSC-99pp0208

NASA Image and Video Library

1999-02-11

KENNEDY SPACE CENTER, FLA. -- In the SPACEHAB Facility for a payload Interface Verification Test (IVT) for their upcoming mission to the International Space Station are (left to right) Mission Specialists Valery Tokarev, Julie Payette (holding a lithium hydroxide canister) and Dan Barry. Other crew members at KSC for the IVT are Commander Kent Rominger, Pilot Rick Husband and Mission Specialists Ellen Ochoa and Tamara Jernigan. Mission STS-96 carries the SPACEHAB Logistics Double Module, which has equipment to further outfit the International Space Station service module and equipment that can be off-loaded from the early U.S. assembly flights. The SPACEHAB carries internal logistics and resupply cargo for station outfitting, plus an external Russian cargo crane to be mounted to the exterior of the Russian station segment and used to perform space walking maintenance activities. The double module stowage provides capacity of up to 10,000 lbs. with the ability to accommodate powered payloads, four external rooftop stowage locations, four double-rack locations (two powered), up to 61 bulkhead-mounted middeck locker locations, and floor storage for large unique items and Soft Stowage. STS-96 is targeted to launch May 20 about 9:32 a.m

High accuracy position method based on computer vision and error analysis

NASA Astrophysics Data System (ADS)

Chen, Shihao; Shi, Zhongke

2003-09-01

The study of high accuracy position system is becoming the hotspot in the field of autocontrol. And positioning is one of the most researched tasks in vision system. So we decide to solve the object locating by using the image processing method. This paper describes a new method of high accuracy positioning method through vision system. In the proposed method, an edge-detection filter is designed for a certain running condition. Here, the filter contains two mainly parts: one is image-processing module, this module is to implement edge detection, it contains of multi-level threshold self-adapting segmentation, edge-detection and edge filter; the other one is object-locating module, it is to point out the location of each object in high accurate, and it is made up of medium-filtering and curve-fitting. This paper gives some analysis error for the method to prove the feasibility of vision in position detecting. Finally, to verify the availability of the method, an example of positioning worktable, which is using the proposed method, is given at the end of the paper. Results show that the method can accurately detect the position of measured object and identify object attitude.

Video Diagnostic for W7-X Stellarator

NASA Astrophysics Data System (ADS)

Sárközi, J.; Grosser, K.; Kocsis, G.; König, R.; Neuner, U.; Molnár, Á.; Petravich, G.; Por, G.; Porempovics, G.; Récsei, S.; Szabó, V.; Szappanos, A.; Zoletnik, S.

2008-03-01

The video diagnostics for W7-X—which is under development—is devoted to observe plasma and frrst wall elements during operation, to warn in case of hot spots and dangerous heat load and to give information about the plasma size, position, edge structure, the geometry and location of magnetic islands and distribution of impurities. The video diagnostics will be mounted on the tangential AEQ-ports of the torus that are not straight and have about 2m length and a typical diameter of 0.1m which makes its realization more difficult. The geometry of the 10 tangential views of the AEQ-ports allows giving an almost complete overview of the vessel interior making this diagnostic indispensable for the machine operation. Different concepts of the diagnostics were investigated and finally the following design was selected. As a large heat load is expected on the optical window located at the plasma-facing end of the AEQ-port, the port window is protected by a cooled pinhole. An uncooled shutter located behind the pinhole can be closed to prevent window contamination during vessel conditioning discharges (glow discharge cleaning) and from inter-pulse deposition of soft a-C:H layers. The imaging optics and the detection sensor are located behind the port window in the port tube, which will be under atmospheric pressure. To detect the visible radiation distribution a new camera system called Event Detection Intelligent Camera (EDICAM) is under development. The system is divided into three major separated components. The Sensor Module contains only the selected CMOS sensor, the analog digital converters and the minimal electronics necessary for the communication with the subsequent camera system module called Image Processing and Control Unit (IPCU). Its simple structure makes the Sensor Module suitable to operate despite being exposed to ionizing (neutron, γ-) radiation. The IPCU, which can be located far from the Sensor Module and therefore far from the plasma, is designed to perform real time evaluation of the images detecting predefined events, managing the sensor read-out and the input triggers and producing the output triggers generated by the detected events. The IPCU can also be used to reduce the amount of the stored data. A Standard 10 Gigabit Ethernet fiber optics connection connects the IPCU module to the PC with GigEVision communication protocol.

View of damaged Apollo 13 Service Module from the Lunar/Command Modules

NASA Image and Video Library

1970-04-17

AS13-58-8458 (17 April 1970) --- This view of the severely damaged Apollo 13 Service Module (SM) was photographed from the Lunar Module/Command Module (LM/CM) following SM jettisoning. An entire SM panel was blown away by the apparent explosion of oxygen tank number two. Two of the three fuel cells are visible at the forward portion of the opening. The hydrogen tanks are located in Sector 4 of the Apollo 13 SM. The apparent rupture of the oxygen tank caused the Apollo 13 crew members to use the LM as a "lifeboat." The LM was jettisoned just prior to Earth re-entry by the CM.

Spectroscopic characterisation of moonmilk deposits in Pozalagua tourist Cave (Karrantza, Basque Country, North of Spain)

NASA Astrophysics Data System (ADS)

Martínez-Arkarazo, I.; Angulo, M.; Zuloaga, O.; Usobiaga, A.; Madariaga, J. M.

2007-12-01

Composition of moonmilk deposits located in different zones of the tourist Dolomite Cave of Pozalagua (Karrantza, Basque Country, North of Spain) was established by Raman spectroscopy. The deposits were located in column bases and detached rocks near a gour full of water or a dripping zone. Hydromagnesite (Mg 5(CO 3) 4(OH) 2·4H 2O) with a strong Raman band at 1116 cm -1 and weaker ones at 1522vw, 1487vw, 1452vw, 756w, 727w, 466w, 434w, 371w, 327m, 291w, 258w, 247vw and 230 m cm -1 was found as the main component of the moonmilk. Aragonite is the unique calcium carbonate compound that sometimes composes the moonmilk but always together with the hydromagnesite. Among non-carbonate minerals, some nitrates (nitrocalcite, niter, nitromagnesite, nitratine and gwihabaite) and sulphates (arkanite) were also identified as minor compounds. Most of the deposits were matt white and pasty, but occasionally some samples appear greyish on the surface. In these samples, carbon particles were also found, apart from the above, and Raman shift changes were observed in the hydromagnesite spectra. Apart from the elements involved in the mentioned minerals, Si, Fe, Mn, Zn and Ti were identified by X-ray microfluorescence as trace elements and the results were correlated with mineral compositions found by Raman measurements. Furthermore, quantification of the soluble salts of moonmilk deposits was carried out by ionic chromatography and the results were chemometrically treated to find correlations among soluble ions and the composition of the mineral phases spectroscopically characterised.

Influenza C virus high seroprevalence rates observed in 3 different population groups.

PubMed

Salez, Nicolas; Mélade, Julien; Pascalis, Hervé; Aherfi, Sarah; Dellagi, Koussay; Charrel, Rémi N; Carrat, Fabrice; de Lamballerie, Xavier

2014-08-01

The epidemiology of Influenza C virus (FLUCV) infections remains poorly characterised. Here, we have examined the age- and location-specific seroprevalence of antibodies against FLUCV in 1441 sera from metropolitan continental France (Marseille), South-West Indian Ocean French territories (Reunion Island) and United-Kingdom (Edinburgh) using a combination of haemagglutination inhibition, virus neutralisation and ELISA assays. Our results show that immunity to FLUCV is common in all locations studied (global seroprevalence values >50%) and that the first immunising contacts generally occur early in life (i.e., in the 0-4 year-old age group). The latter item is further supported by the detection of FLUCV RNA by RT-PCR in naso-pharyngeal samples collected in patient attending the Emergency Room of the Public hospitals of Marseille, France with a large majority of children under 10 years-old: 17 (60.7%) in children ≤3 yo, 10 (35.7%) in the 4-10 yo age group and 1 (3.6%) in an adult (49yo). The temporal distribution of cases was atypical with regard to influenza (a large proportion of cases occurred in spring and summer) and the clinical presentation was diverse, including but being not limited to classical Influenza-like-Ilnesses. Altogether, our results indicate an intense circulation of FLUCV in the different study areas and an early occurrence of infection in human life. Flu C appears to be a widely under-diagnosed and under-studied human paediatric disease that obviously deserves further clinical and epidemiological characterisation. Copyright © 2014 The British Infection Association. Published by Elsevier Ltd. All rights reserved.

Spectroscopic characterisation of moonmilk deposits in Pozalagua tourist cave (Karrantza, Basque Country, North of Spain).

PubMed

Martínez-Arkarazo, I; Angulo, M; Zuloaga, O; Usobiaga, A; Madariaga, J M

2007-12-15

Composition of moonmilk deposits located in different zones of the tourist Dolomite Cave of Pozalagua (Karrantza, Basque Country, North of Spain) was established by Raman spectroscopy. The deposits were located in column bases and detached rocks near a gour full of water or a dripping zone. Hydromagnesite (Mg(5)(CO(3))(4)(OH)(2).4H(2)O) with a strong Raman band at 1116 cm(-1) and weaker ones at 1522vw, 1487vw, 1452vw, 756w, 727w, 466w, 434w, 371w, 327m, 291w, 258w, 247vw and 230 m cm(-1) was found as the main component of the moonmilk. Aragonite is the unique calcium carbonate compound that sometimes composes the moonmilk but always together with the hydromagnesite. Among non-carbonate minerals, some nitrates (nitrocalcite, niter, nitromagnesite, nitratine and gwihabaite) and sulphates (arkanite) were also identified as minor compounds. Most of the deposits were matt white and pasty, but occasionally some samples appear greyish on the surface. In these samples, carbon particles were also found, apart from the above, and Raman shift changes were observed in the hydromagnesite spectra. Apart from the elements involved in the mentioned minerals, Si, Fe, Mn, Zn and Ti were identified by X-ray microfluorescence as trace elements and the results were correlated with mineral compositions found by Raman measurements. Furthermore, quantification of the soluble salts of moonmilk deposits was carried out by ionic chromatography and the results were chemometrically treated to find correlations among soluble ions and the composition of the mineral phases spectroscopically characterised.

Social and place-focused communities in location-based online social networks

NASA Astrophysics Data System (ADS)

Brown, Chloë; Nicosia, Vincenzo; Scellato, Salvatore; Noulas, Anastasios; Mascolo, Cecilia

2013-06-01

Thanks to widely available, cheap Internet access and the ubiquity of smartphones, millions of people around the world now use online location-based social networking services. Understanding the structural properties of these systems and their dependence upon users' habits and mobility has many potential applications, including resource recommendation and link prediction. Here, we construct and characterise social and place-focused graphs by using longitudinal information about declared social relationships and about users' visits to physical places collected from a popular online location-based social service. We show that although the social and place-focused graphs are constructed from the same data set, they have quite different structural properties. We find that the social and location-focused graphs have different global and meso-scale structure, and in particular that social and place-focused communities have negligible overlap. Consequently, group inference based on community detection performed on the social graph alone fails to isolate place-focused groups, even though these do exist in the network. By studying the evolution of tie structure within communities, we show that the time period over which location data are aggregated has a substantial impact on the stability of place-focused communities, and that information about place-based groups may be more useful for user-centric applications than that obtained from the analysis of social communities alone.

Fifteen years of research on oral-facial-digital syndromes: from 1 to 16 causal genes.

PubMed

Bruel, Ange-Line; Franco, Brunella; Duffourd, Yannis; Thevenon, Julien; Jego, Laurence; Lopez, Estelle; Deleuze, Jean-François; Doummar, Diane; Giles, Rachel H; Johnson, Colin A; Huynen, Martijn A; Chevrier, Véronique; Burglen, Lydie; Morleo, Manuela; Desguerres, Isabelle; Pierquin, Geneviève; Doray, Bérénice; Gilbert-Dussardier, Brigitte; Reversade, Bruno; Steichen-Gersdorf, Elisabeth; Baumann, Clarisse; Panigrahi, Inusha; Fargeot-Espaliat, Anne; Dieux, Anne; David, Albert; Goldenberg, Alice; Bongers, Ernie; Gaillard, Dominique; Argente, Jesús; Aral, Bernard; Gigot, Nadège; St-Onge, Judith; Birnbaum, Daniel; Phadke, Shubha R; Cormier-Daire, Valérie; Eguether, Thibaut; Pazour, Gregory J; Herranz-Pérez, Vicente; Goldstein, Jaclyn S; Pasquier, Laurent; Loget, Philippe; Saunier, Sophie; Mégarbané, André; Rosnet, Olivier; Leroux, Michel R; Wallingford, John B; Blacque, Oliver E; Nachury, Maxence V; Attie-Bitach, Tania; Rivière, Jean-Baptiste; Faivre, Laurence; Thauvin-Robinet, Christel

2017-06-01

Oral-facial-digital syndromes (OFDS) gather rare genetic disorders characterised by facial, oral and digital abnormalities associated with a wide range of additional features (polycystic kidney disease, cerebral malformations and several others) to delineate a growing list of OFDS subtypes. The most frequent, OFD type I, is caused by a heterozygous mutation in the OFD1 gene encoding a centrosomal protein. The wide clinical heterogeneity of OFDS suggests the involvement of other ciliary genes. For 15 years, we have aimed to identify the molecular bases of OFDS. This effort has been greatly helped by the recent development of whole-exome sequencing (WES). Here, we present all our published and unpublished results for WES in 24 cases with OFDS. We identified causal variants in five new genes ( C2CD3 , TMEM107 , INTU , KIAA0753 and IFT57 ) and related the clinical spectrum of four genes in other ciliopathies ( C5orf42 , TMEM138 , TMEM231 and WDPCP ) to OFDS. Mutations were also detected in two genes previously implicated in OFDS. Functional studies revealed the involvement of centriole elongation, transition zone and intraflagellar transport defects in OFDS, thus characterising three ciliary protein modules: the complex KIAA0753-FOPNL-OFD1, a regulator of centriole elongation; the Meckel-Gruber syndrome module, a major component of the transition zone; and the CPLANE complex necessary for IFT-A assembly. OFDS now appear to be a distinct subgroup of ciliopathies with wide heterogeneity, which makes the initial classification obsolete. A clinical classification restricted to the three frequent/well-delineated subtypes could be proposed, and for patients who do not fit one of these three main subtypes, a further classification could be based on the genotype. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Magnetic nanoparticle hyperthermia enhances radiation therapy: A study in mouse models of human prostate cancer

PubMed Central

Attaluri, Anilchandra; Kandala, Sri Kamal; Wabler, Michele; Zhou, Haoming; Cornejo, Christine; Armour, Michael; Hedayati, Mohammad; Zhang, Yonggang; DeWeese, Theodore L.; Herman, Cila; Ivkov, Robert

2015-01-01

Purpose We aimed to characterise magnetic nanoparticle hyperthermia (mNPH) with radiation therapy (RT) for prostate cancer. Methods Human prostate cancer subcutaneous tumours, PC3 and LAPC-4, were grown in nude male mice. When tumours measured 150 mm3 magnetic iron oxide nanoparticles (MIONPs) were injected into tumours to a target dose of 5.5 mg Fe/cm3 tumour, and treated 24 h later by exposure to alternating magnetic field (AMF). Mice were randomly assigned to one of four cohorts to characterise (1) intratumour MIONP distribution, (2) effects of variable thermal dose mNPH (fixed AMF peak amplitude 24 kA/m at 160±5 kHz) with/without RT (5 Gy), (3) effects of RT (RT5: 5 Gy; RT8: 8 Gy), and (4) fixed thermal dose mNPH (43 °C for 20min) with/without RT (5 Gy). MIONP concentration and distribution were assessed following sacrifice and tissue harvest using inductively coupled plasma mass spectrometry (ICP-MS) and Prussian blue staining, respectively. Tumour growth was monitored and compared among treated groups. Results LAPC-4 tumours retained higher MIONP concentration and more uniform distribution than did PC3 tumours. AMF power modulation provided similar thermal dose for mNPH and combination therapy groups (CEM43: LAPC-4: 33.6 ± 3.4 versus 25.9 ± 0.8, and PC3: 27.19 ± 0.7 versus 27.50 ± 0.6), thereby overcoming limitations of MIONP distribution and yielding statistically significant tumour growth delay. Conclusion PC3 and LAPC-4 tumours represent two biological models that demonstrate different patterns of nanoparticle retention and distribution, offering a model to make comparisons of these effects for mNPH. Modulating power for mNPH offers potential to overcome limitations of MIONP distribution to enhance mNPH. PMID:25811736

Magnetic nanoparticle hyperthermia enhances radiation therapy: A study in mouse models of human prostate cancer.

PubMed

Attaluri, Anilchandra; Kandala, Sri Kamal; Wabler, Michele; Zhou, Haoming; Cornejo, Christine; Armour, Michael; Hedayati, Mohammad; Zhang, Yonggang; DeWeese, Theodore L; Herman, Cila; Ivkov, Robert

2015-06-01

We aimed to characterise magnetic nanoparticle hyperthermia (mNPH) with radiation therapy (RT) for prostate cancer. Human prostate cancer subcutaneous tumours, PC3 and LAPC-4, were grown in nude male mice. When tumours measured 150 mm3 magnetic iron oxide nanoparticles (MIONPs) were injected into tumours to a target dose of 5.5 mg Fe/cm3 tumour, and treated 24 h later by exposure to alternating magnetic field (AMF). Mice were randomly assigned to one of four cohorts to characterise (1) intratumour MIONP distribution, (2) effects of variable thermal dose mNPH (fixed AMF peak amplitude 24 kA/m at 160 ± 5 kHz) with/without RT (5 Gy), (3) effects of RT (RT5: 5 Gy; RT8: 8 Gy), and (4) fixed thermal dose mNPH (43 °C for 20 min) with/without RT (5 Gy). MIONP concentration and distribution were assessed following sacrifice and tissue harvest using inductively coupled plasma mass spectrometry (ICP-MS) and Prussian blue staining, respectively. Tumour growth was monitored and compared among treated groups. LAPC-4 tumours retained higher MIONP concentration and more uniform distribution than did PC3 tumours. AMF power modulation provided similar thermal dose for mNPH and combination therapy groups (CEM43: LAPC-4: 33.6 ± 3.4 versus 25.9 ± 0.8, and PC3: 27.19 ± 0.7 versus 27.50 ± 0.6), thereby overcoming limitations of MIONP distribution and yielding statistically significant tumour growth delay. PC3 and LAPC-4 tumours represent two biological models that demonstrate different patterns of nanoparticle retention and distribution, offering a model to make comparisons of these effects for mNPH. Modulating power for mNPH offers potential to overcome limitations of MIONP distribution to enhance mNPH.

Characterisation of the pharmacological profile of desoxymethyltestosterone (Madol), a steroid misused for doping.

PubMed

Diel, P; Friedel, A; Geyer, H; Kamber, M; Laudenbach-Leschowsky, U; Schänzer, W; Thevis, M; Vollmer, G; Zierau, O

2007-02-28

Desoxymethyltestosterone (DMT), also known as Madol, is a steroid recently identified to be misused as a doping agent. Since, the knowledge of functions of this substance is rather limited, it was our aim to characterise the pharmacological profile of DMT and to identify potential adverse side effects. DMT was synthesised, its purity was confirmed and its biological activity was tested. The potency of Madol (DMT) to transactivate androgen receptor (AR) dependent reporter gene expression was two times lower as compared to dihydrotestosterone (DHT). Receptor binding tests demonstrate that DMT binds with high selectivity to the AR, binding to the progesterone receptor (PR) was low. In vivo experiments in orchiectomised rats demonstrated that treatment with DMT resulted only in a stimulation of the weight of the levator ani muscle; the prostate and seminal vesicle weights remained unaffected. Like testosterone, administration of DMT resulted in a stimulation of IGF-1 and myostatin mRNA expression in the gastrocnemius muscle. In the prostate proliferation was stimulated by TP (testosteronepropionate), but remained unaffected by DMT. Remarkably, treatment with DMT, in contrast to TP, resulted in a significant increase of the heart weight. In the liver, DMT slightly stimulates the expression of the tyrosine aminotransferase gene (TAT). Our results demonstrate that DMT is a potent AR agonist with an anabolic activity. Besides the levator ani weight, DMT also modulates the gene expression in the musculus gastrocnemius. The observed stimulation of TAT expression in the liver and the significant increase of the heart weight after DMT treatment can be taken as an indication for side effects. Summarizing these data it is obvious that DMT is a powerful anabolic steroid with selective androgen receptor modulators (SARM) like properties and some indications for toxic side effects. Therefore, there is a need for a strict control of a possible misuse.

A novel extracellular metallopeptidase domain shared by animal host-associated mutualistic and pathogenic microbes.

PubMed

Nakjang, Sirintra; Ndeh, Didier A; Wipat, Anil; Bolam, David N; Hirt, Robert P

2012-01-01

The mucosal microbiota is recognised as an important factor for our health, with many disease states linked to imbalances in the normal community structure. Hence, there is considerable interest in identifying the molecular basis of human-microbe interactions. In this work we investigated the capacity of microbes to thrive on mucosal surfaces, either as mutualists, commensals or pathogens, using comparative genomics to identify co-occurring molecular traits. We identified a novel domain we named M60-like/PF13402 (new Pfam entry PF13402), which was detected mainly among proteins from animal host mucosa-associated prokaryotic and eukaryotic microbes ranging from mutualists to pathogens. Lateral gene transfers between distantly related microbes explained their shared M60-like/PF13402 domain. The novel domain is characterised by a zinc-metallopeptidase-like motif and is distantly related to known viral enhancin zinc-metallopeptidases. Signal peptides and/or cell surface anchoring features were detected in most microbial M60-like/PF13402 domain-containing proteins, indicating that these proteins target an extracellular substrate. A significant subset of these putative peptidases was further characterised by the presence of associated domains belonging to carbohydrate-binding module family 5/12, 32 and 51 and other glycan-binding domains, suggesting that these novel proteases are targeted to complex glycoproteins such as mucins. An in vitro mucinase assay demonstrated degradation of mammalian mucins by a recombinant form of an M60-like/PF13402-containing protein from the gut mutualist Bacteroides thetaiotaomicron. This study reveals that M60-like domains are peptidases targeting host glycoproteins. These peptidases likely play an important role in successful colonisation of both vertebrate mucosal surfaces and the invertebrate digestive tract by both mutualistic and pathogenic microbes. Moreover, 141 entries across various peptidase families described in the MEROPS database were also identified with carbohydrate-binding modules defining a new functional context for these glycan-binding domains and providing opportunities to engineer proteases targeting specific glycoproteins for both biomedical and industrial applications.

Integrated Design of Basic Training, Practicum and End-of-Course Assignment Modules in the Teacher Training Degree: Perception of University Teachers, Students, and School Teachers

NASA Astrophysics Data System (ADS)

Torremorell, Maria Carme Boqué; de Nicolás, Montserrat Alguacil; Valls, Mercè Pañellas

Teacher training at the Blanquerna Faculty of Psychology and Educational and Sports Sciences (FPCEE), in Barcelona, has a long pedagogical tradition based on teaching innovation. Its educational style is characterised by methods focused on the students' involvement and on close collaboration with teaching practice centres. Within a core subject in the Teacher Training diploma course, students were asked to assess different methodological proposals aimed at promoting the development of their personal, social, and professional competences. In the assessment surveys, from a sample of 145 students, scores for variables very satisfactory or satisfactory ranged from 95.8 % to 83.4 % for the entire set of methodological actions under analysis. Data obtained in this first research phase were very useful to design basic training modules for the new Teacher Training Degree. In the second phase (in process), active teachers are asked for their perception on the orientation of the practicum, its connection with the end-of-course assignment, and the in-service student's incidence on innovation processes at school.

Amino acid-dependent signaling via S6K1 and MYC is essential for regulation of rDNA transcription

PubMed Central

Kang, Jian; Kusnadi, Eric P.; Ogden, Allison J.; Hicks, Rodney J.; Bammert, Lukas; Kutay, Ulrike; Hung, Sandy; Sanij, Elaine; Hannan, Ross D.; Hannan, Katherine M.; Pearson, Richard B.

2016-01-01

Dysregulation of RNA polymerase I (Pol I)-dependent ribosomal DNA (rDNA) transcription is a consistent feature of malignant transformation that can be targeted to treat cancer. Understanding how rDNA transcription is coupled to the availability of growth factors and nutrients will provide insight into how ribosome biogenesis is maintained in a tumour environment characterised by limiting nutrients. We demonstrate that modulation of rDNA transcription initiation, elongation and rRNA processing is an immediate, co-regulated response to altered amino acid abundance, dependent on both mTORC1 activation of S6K1 and MYC activity. Growth factors regulate rDNA transcription initiation while amino acids modulate growth factor-dependent rDNA transcription by primarily regulating S6K1-dependent rDNA transcription elongation and processing. Thus, we show for the first time amino acids regulate rRNA synthesis by a distinct, post-initiation mechanism, providing a novel model for integrated control of ribosome biogenesis that has implications for understanding how this process is dysregulated in cancer. PMID:27385002

Iron from haemoglobin and haemin modulates nucleotide hydrolysis in Trichomonas vaginalis.

PubMed

Vieira, Patrícia de Brum; Silva, Nícolas Luiz Feijó; Kist, Luiza Wilges; Oliveira, Giovanna Medeiros Tavares de; Bogo, Maurício Reis; Carli, Geraldo Atillio de; Macedo, Alexandre José; Tasca, Tiana

2015-04-01

Extracellular ATP may act as a danger signalling molecule, inducing inflammation and immune responses in infection sites. The ectonucleotidases NTPDase and ecto-5'-nucleotidase are enzymes that modulate extracellular nucleotide levels; these enzymes have been previously characterised in Trichomonas vaginalis. Iron plays an important role in the complex trichomonal pathogenesis. Herein, the effects of iron on growth, nucleotide hydrolysis and NTPDase gene expression in T. vaginalis isolates from female and male patients were evaluated. Iron from different sources sustained T. vaginalis growth. Importantly, iron from haemoglobin (HB) and haemin (HM) enhanced NTPDase activity in isolates from female patients and conversely reduced the enzyme activity in isolates from male patients. Iron treatments could not alter the NTPDase transcript levels in T. vaginalis. Furthermore, our results reveal a distinct ATP, ADP and AMP hydrolysis profile between isolates from female and male patients influenced by iron from HB and HM. Our data indicate the participation of NTPDase and ecto-5'-nucleotidase in the establishment of trichomonas infection through ATP degradation and adenosine production influenced by iron.

Method and apparatus for pulse width modulation control of an AC induction motor

DOEpatents

Geppert, Steven; Slicker, James M.

1984-01-01

An inverter is connected between a source of DC power and a three-phase AC induction motor, and a micro-processor-based circuit controls the inverter using pulse width modulation techniques. In the disclosed method of pulse width modulation, both edges of each pulse of a carrier pulse train are equally modulated by a time proportional to sin .THETA., where .THETA. is the angular displacement of the pulse center at the motor stator frequency from a fixed reference point on the carrier waveform. The carrier waveform frequency is a multiple of the motor stator frequency. The modulated pulse train is then applied to each of the motor phase inputs with respective phase shifts of 120.degree. at the stator frequency. Switching control commands of electronic switches in the inverter are stored in a random access memory (RAM) and the locations of the RAM are successively read out in a cyclic manner, each bit of a given RAM location controlling a respective phase input of the motor. The DC power source preferably comprises rechargeable batteries and all but one of the electronic switches in the inverter can be disabled, the remaining electronic switch being part of a "flyback" DC-DC converter circuit for recharging the battery.

Deficient attention modulation of lateralized alpha power in schizophrenia.

PubMed

Kustermann, Thomas; Rockstroh, Brigitte; Kienle, Johanna; Miller, Gregory A; Popov, Tzvetan

2016-06-01

Modulation of 8-14 Hz (alpha) activity in posterior brain regions is associated with covert attention deployment in visuospatial tasks. Alpha power decrease contralateral to to-be-attended stimuli is believed to foster subsequent processing, such as retention of task-relevant input. Degradation of this alpha-regulation mechanism may reflect an early stage of disturbed attention regulation contributing to impaired attention and working memory commonly found in schizophrenia. The present study tested this hypothesis of early disturbed attention regulation by examining alpha power modulation in a lateralized cued delayed response task in 14 schizophrenia patients (SZ) and 25 healthy controls (HC). Participants were instructed to remember the location of a 100-ms saccade-target cue in the left or right visual hemifield in order to perform a delayed saccade to that location after a retention interval. As expected, alpha power decrease during the retention interval was larger in contralateral than ipsilateral posterior regions, and SZ showed less of this lateralization than did HC. In particular, SZ failed to show hemifield-specific alpha modulation in posterior right hemisphere. Results suggest less efficient modulation of alpha oscillations that are considered critical for attention deployment and item encoding and, hence, may affect subsequent spatial working memory performance. © 2016 Society for Psychophysiological Research.

Method and apparatus for pulse width modulation control of an AC induction motor

NASA Technical Reports Server (NTRS)

Geppert, Steven (Inventor); Slicker, James M. (Inventor)

1984-01-01

An inverter is connected between a source of DC power and a three-phase AC induction motor, and a micro-processor-based circuit controls the inverter using pulse width modulation techniques. In the disclosed method of pulse width modulation, both edges of each pulse of a carrier pulse train are equally modulated by a time proportional to sin .THETA., where .THETA. is the angular displacement of the pulse center at the motor stator frequency from a fixed reference point on the carrier waveform. The carrier waveform frequency is a multiple of the motor stator frequency. The modulated pulse train is then applied to each of the motor phase inputs with respective phase shifts of 120.degree. at the stator frequency. Switching control commands of electronic switches in the inverter are stored in a random access memory (RAM) and the locations of the RAM are successively read out in a cyclic manner, each bit of a given RAM location controlling a respective phase input of the motor. The DC power source preferably comprises rechargeable batteries and all but one of the electronic switches in the inverter can be disabled, the remaining electronic switch being part of a flyback DC-DC converter circuit for recharging the battery.

Changes in predictive cuing modulate the hemispheric distribution of the P1 inhibitory response to attentional targets.

PubMed

Lasaponara, Stefano; D' Onofrio, Marianna; Dragone, Alessio; Pinto, Mario; Caratelli, Ludovica; Doricchi, Fabrizio

2017-05-01

Brain activity related to orienting of attention with spatial cues and brain responses to attentional targets are influenced the probabilistic contingency between cues and targets. Compared to predictive cues, cues predicting at chance the location of targets reduce the filtering out of uncued locations and the costs in reorienting attention to targets presented at these locations. Slagter et al. (2016) have recently suggested that the larger target related P1 component that is found in the hemisphere ipsilateral to validly cued targets reflects stimulus-driven inhibition in the processing of the unstimulated side of space contralateral to the same hemisphere. Here we verified whether the strength of this inhibition and the amplitude of the corresponding P1 wave are modulated by the probabilistic link between cues and targets. Healthy participants performed a task of endogenous orienting once with predictive and once with non-predictive directional cues. In the non-predictive condition we observed a drop in the amplitude of the P1 ipsilateral to the target and in the costs of reorienting. No change in the inter-hemispheric latencies of the P1 was found between the two predictive conditions. The N1 facilitatory component was unaffected by predictive cuing. These results show that the predictive context modulates the strength of the inhibitory P1 response and that this modulation is not matched with changes in the inter-hemispheric interaction between the P1 generators of the two hemispheres. Copyright © 2017. Published by Elsevier Ltd.

Passive thermal regulation of flat PV modules by coupling the mechanisms of evaporative and fin cooling

NASA Astrophysics Data System (ADS)

Chandrasekar, M.; Senthilkumar, T.

2016-07-01

A passive thermal regulation technique with fins in conjunction with cotton wicks is developed in the present work for controlling the temperature of PV module during its operation. Experiments were conducted with the developed technique in the location of Tiruchirappalli (78.6°E and 10.8°N), Tamil Nadu, India with flat 25 Wp PV module and its viability was confirmed. The PV module temperature got reduced by 12 % while the electrical yield is increased by 14 % with the help of the developed cooling system. Basic energy balance equation applicable for PV module was used to evaluate the module temperatures and a fair agreement was obtained between the theoretical and experimental values for the cases of with cooling and without cooling.

Generation of ultra-wideband triplet pulses based on four-wave mixing and phase-to-intensity modulation conversion.

PubMed

Li, Wei; Wang, Li Xian; Hofmann, Werner; Zhu, Ning Hua; Bimberg, Dieter

2012-08-27

We propose and demonstrate a novel scheme to generate ultra-wideband (UWB) triplet pulses based on four-wave mixing and phase-to-intensity modulation conversion. First a phase-modulated Gaussian doublet pulse is generated by four-wave mixing in a highly nonlinear fiber. Then an UWB triplet pulse is generated by generating the first-order derivative of the phase-modulated Gaussian doublet pulse using an optical filter serving as a frequency discriminator. By locating the optical signal at the linear slope of the optical filter, the phase modulated Gaussian doublet pulse is converted to an intensity-modulated UWB triplet pulse which well satisfies the Federal Communications Commission spectral mask requirements, even in the extremely power-restricted global positioning system band.

Negative ion beam characterisation in BATMAN by mini-STRIKE: Improved design and new measurements

NASA Astrophysics Data System (ADS)

Serianni, G.; Bonomo, F.; Brombin, M.; Cervaro, V.; Chitarin, G.; Cristofaro, S.; Delogu, R.; De Muri, M.; Fasolo, D.; Fonnesu, N.; Franchin, L.; Franzen, P.; Ghiraldelli, R.; Molon, F.; Muraro, A.; Pasqualotto, R.; Ruf, B.; Schiesko, L.; Tollin, M.; Veltri, P.

2015-04-01

The ITER project requires additional heating provided by two injectors of neutral beams resulting from the neutralisation of accelerated negative ions. To study and optimise negative ion production, the SPIDER test facility (particle energy 100keV; beam current 50A) is under construction in Padova, with the aim of testing beam characteristics and to verify the source proper operation. The SPIDER beam will be characterised by the instrumented calorimeter STRIKE, whose main components are one-directional carbon fibre carbon composite tiles. Some prototype tiles have been employed in 2012 as a small-scale version (mini-STRIKE) of the entire system to investigate the features of the beam from BATMAN at IPP-Garching. As the BATMAN beamlets are superposed at the measurement position, about 1m from the grounded grid, an actively cooled copper mask is located in front of the tiles; holes in the mask create an artificial beamlet structure. Recently the mini-STRIKE has been updated, taking into account the results obtained in the first campaign. In particular the spatial resolution of the system has been improved by increasing the number of the copper mask holes. Moreover a custom measurement system has been realized for the thermocouple signals and employed in BATMAN in view of its use in SPIDER. The present contribution gives a description of the new design of the system as well as of the thermocouple measurements system and its field test. A new series of measurements has been carried out in BATMAN. The BATMAN beam characterisation in different experimental conditions is presented.

Negative ion beam characterisation in BATMAN by mini-STRIKE: Improved design and new measurements

DOE Office of Scientific and Technical Information (OSTI.GOV)

Serianni, G., E-mail: gianluigi.serianni@igi.cnr.it; Brombin, M.; Cervaro, V.

The ITER project requires additional heating provided by two injectors of neutral beams resulting from the neutralisation of accelerated negative ions. To study and optimise negative ion production, the SPIDER test facility (particle energy 100keV; beam current 50A) is under construction in Padova, with the aim of testing beam characteristics and to verify the source proper operation. The SPIDER beam will be characterised by the instrumented calorimeter STRIKE, whose main components are one-directional carbon fibre carbon composite tiles. Some prototype tiles have been employed in 2012 as a small-scale version (mini-STRIKE) of the entire system to investigate the features ofmore » the beam from BATMAN at IPP-Garching. As the BATMAN beamlets are superposed at the measurement position, about 1m from the grounded grid, an actively cooled copper mask is located in front of the tiles; holes in the mask create an artificial beamlet structure. Recently the mini-STRIKE has been updated, taking into account the results obtained in the first campaign. In particular the spatial resolution of the system has been improved by increasing the number of the copper mask holes. Moreover a custom measurement system has been realized for the thermocouple signals and employed in BATMAN in view of its use in SPIDER. The present contribution gives a description of the new design of the system as well as of the thermocouple measurements system and its field test. A new series of measurements has been carried out in BATMAN. The BATMAN beam characterisation in different experimental conditions is presented.« less

Characterisation of the Context-Dependence of the Gene Concept in Research Articles. Possible Consequences for Teaching Concepts with Multiple Meanings

NASA Astrophysics Data System (ADS)

Flodin, Veronica S.

2017-03-01

The purpose of this study is to interpret and qualitatively characterise the content in some research articles and evaluate cases of possible difference in meanings of the gene concept used. Using a reformulation of Hirst's criteria of forms of knowledge, articles from five different sub-disciplines in biology (transmission genetic, molecular biology, genomics, developmental biology and population genetics) were characterised according to knowledge project, methods used and conceptual contexts. Depending on knowledge project, the gene may be used as a location of recombination, a target of regulatory proteins, a carrier of regulatory sequences, a cause in organ formation or a basis for a genetic map. Methods used range from catching wild birds and dissecting beetle larvae to growing yeast cells in 94 small wells as well as mapping of recombinants, doing statistical calculations, immunoblotting analysis of protein levels, analysis of gene expression with PCR, immunostaining of embryos and automated constructions of multi-locus linkage maps. The succeeding conceptual contexts focused around concepts as meiosis and chromosome, DNA and regulation, cell fitness and production, development and organ formation, conservation and evolution. These contextual differences lead to certain content leaps in relation to different conceptual schemes. The analysis of the various uses of the gene concept shows how differences in methodologies and questions entail a concept that escapes single definitions and "drift around" in meanings. These findings make it important to ask how science might use concepts as tools of specific inquiries and to discuss possible consequences for biology education.

Discriminating the Mediterranean Pinus spp. using the land surface phenology extracted from the whole MODIS NDVI time series and machine learning algorithms

NASA Astrophysics Data System (ADS)

Rodriguez-Galiano, Victor; Aragones, David; Caparros-Santiago, Jose A.; Navarro-Cerrillo, Rafael M.

2017-10-01

Land surface phenology (LSP) can improve the characterisation of forest areas and their change processes. The aim of this work was: i) to characterise the temporal dynamics in Mediterranean Pinus forests, and ii) to evaluate the potential of LSP for species discrimination. The different experiments were based on 679 mono-specific plots for the 5 native species on the Iberian Peninsula: P. sylvestris, P. pinea, P. halepensis, P. nigra and P. pinaster. The entire MODIS NDVI time series (2000-2016) of the MOD13Q1 product was used to characterise phenology. The following phenological parameters were extracted: the start, end and median days of the season, and the length of the season in days, as well as the base value, maximum value, amplitude and integrated value. Multi-temporal metrics were calculated to synthesise the inter-annual variability of the phenological parameters. The species were discriminated by the application of Random Forest (RF) classifiers from different subsets of variables: model 1) NDVI-smoothed time series, model 2) multi-temporal metrics of the phenological parameters, and model 3) multi-temporal metrics and the auxiliary physical variables (altitude, slope, aspect and distance to the coastline). Model 3 was the best, with an overall accuracy of 82%, a kappa coefficient of 0.77 and whose most important variables were: elevation, coast distance, and the end and start days of the growing season. The species that presented the largest errors was P. nigra, (kappa= 0.45), having locations with a similar behaviour to P. sylvestris or P. pinaster.

Identification and characterisation of the angiotensin converting enzyme-3 (ACE3) gene: a novel mammalian homologue of ACE

PubMed Central

Rella, Monika; Elliot, Joann L; Revett, Timothy J; Lanfear, Jerry; Phelan, Anne; Jackson, Richard M; Turner, Anthony J; Hooper, Nigel M

2007-01-01

Background Mammalian angiotensin converting enzyme (ACE) plays a key role in blood pressure regulation. Although multiple ACE-like proteins exist in non-mammalian organisms, to date only one other ACE homologue, ACE2, has been identified in mammals. Results Here we report the identification and characterisation of the gene encoding a third homologue of ACE, termed ACE3, in several mammalian genomes. The ACE3 gene is located on the same chromosome downstream of the ACE gene. Multiple sequence alignment and molecular modelling have been employed to characterise the predicted ACE3 protein. In mouse, rat, cow and dog, the predicted protein has mutations in some of the critical residues involved in catalysis, including the catalytic Glu in the HEXXH zinc binding motif which is Gln, and ESTs or reverse-transcription PCR indicate that the gene is expressed. In humans, the predicted ACE3 protein has an intact HEXXH motif, but there are other deletions and insertions in the gene and no ESTs have been identified. Conclusion In the genomes of several mammalian species there is a gene that encodes a novel, single domain ACE-like protein, ACE3. In mouse, rat, cow and dog ACE3, the catalytic Glu is replaced by Gln in the putative zinc binding motif, indicating that in these species ACE3 would lack catalytic activity as a zinc metalloprotease. In humans, no evidence was found that the ACE3 gene is expressed and the presence of deletions and insertions in the sequence indicate that ACE3 is a pseudogene. PMID:17597519

Characterising boiler ash from a circulating fluidised bed municipal solid waste incinerator and distribution of PCDD/F and PCB.

PubMed

Zhang, Mengmei; Buekens, Alfons; Li, Xiaodong

2018-05-31

In this study, ash samples were collected from five locations situated in the boiler of a circulating fluidised bed municipal solid waste incinerator (high- and low-temperature superheater, evaporator tubes and upper and lower economiser). These samples represent a huge range of flue gas temperatures and were characterised for their particle size distribution, surface characteristics, elemental composition, chemical forms of carbon and chlorine and distribution of polychlorinated dibenzo-p-dioxins (PCDD), dibenzofurans (PCDF) and biphenyls (PCB). Enrichment of chlorine, one of the main elements of organochlorinated pollutants, and copper, zinc and lead, major catalytic metals for dioxin-like compounds, was observed in lower-temperature ash deposits. The speciation of carbon and chlorine on ash surfaces was established, showing a positive correlation between organic chlorine and oxygen-containing carbon functional groups. The load of PCDD/F and PCB (especially dioxin-like PCB) tends to rise rapidly with falling temperature of flue gas, reaching their highest value in economiser ashes. The formation of PCDD/F congeners through the chlorophenol precursor route apparently was enhanced downstream the boiler. Principal component analysis (PCA) was applied to study the links between the ash characteristics and distribution of chloro-aromatics. The primary purpose of this study is improving the understanding of any links between the characteristics of ash from waste heat systems and its potential to form PCDD/F and PCB. The question is raised whether further characterisation of fly ash may assist to establish a diagnosis of poor plant operation, inclusive the generation, destruction and eventual emission of persistent organic pollutants (POPs).

Rigorous Characterisation of a Novel, Statistically-Based Ocean Colour Algorithm for the PACE Mission

NASA Astrophysics Data System (ADS)

Craig, S. E.; Lee, Z.; Du, K.; Lin, J.

2016-02-01

An approach based on empirical orthogonal function (EOF) analysis of ocean colour spectra has been shown to accurately derive inherent optical properties (IOPs) and chlorophyll concentration in scenarios, such as optically complex waters, where standard algorithms often perform poorly. The algorithm has been successfully used in a number of regional applications, and has also shown promise in a global implementation based on the NASA NOMAD data set. Additionally, it has demonstrated the unique ability to derive ocean colour products from top of atmosphere (TOA) signals with either no or minimal atmospheric correction applied. Due to its high potential for use over coastal and inland waters, the EOF approach is currently being rigorously characterised as part of a suite of approaches that will be used to support the new NASA ocean colour mission, PACE (Pre-Aerosol, Clouds and ocean Ecosystem). A major component in this model characterisation is the generation of a synthetic TOA data set using a coupled ocean-atmosphere radiative transfer model, which has been run to mimic PACE spectral resolution, and under a wide range of geographical locations, water constituent concentrations, and sea surface and atmospheric conditions. The resulting multidimensional data set will be analysed, and results presented on the sensitivity of the model to various combinations of parameters, and preliminary conclusions made regarding the optimal implementation strategy of this promising approach (e.g. on a global, optical water type or regional basis). This will provide vital guidance for operational implementation of the model for both existing satellite ocean colour sensors and the upcoming PACE mission.

The neural correlates of competition during memory retrieval are modulated by attention to the cues

PubMed Central

Danker, Jared F.; Fincham, Jon M.; Anderson, John R.

2011-01-01

As people learn more facts about a concept, those facts become more difficult to remember. This is called the fan effect, where fan refers to the number of facts known about a concept. Increasing fan has been shown to decrease accuracy and increase response time and left ventrolateral prefrontal cortex (VLPFC) activity during retrieval. In this study, participants learned 36 arbitrary person-location pairings and had to recognize them while we recorded brain activity using fMRI. We separately manipulated the fan of each person and location, as well as the training procedure with which each pair was studied. In the person focus condition, participants studied pairs with a picture of the person’s face and used the person as a retrieval cue during training. In the location focus condition, participants studied pairs with a picture of the location and used the location as a retrieval cue during training. We found that the fan of the focused cue had a greater effect on response time, accuracy, and left VLPFC activity during retrieval than the fan of the unfocused cue. We also found that the parahippocampal place area (PPA) was more active during the recognition of pairs studied in the location focus condition, but not when the fan of the location was high. Overall, we found opposite effects of fan on VLPFC and PPA that were modulated by cue focus. PMID:21549721

Apollo 10 view of the Earth rising above the lunar horizon

NASA Image and Video Library

1969-05-18

AS10-27-3890 (18-26 May 1969) --- A view of Earth rising above the lunar horizon photographed from the Apollo 10 Lunar Module, looking west in the direction of travel. The Lunar Module at the time the picture was taken was located above the lunar farside highlands at approximately 105 degrees east longitude.

Troubleshooting of an Electromechanical System (Westinghouse PLC Controlling a Pneumatic Robot). High-Technology Training Module.

ERIC Educational Resources Information Center

Tucker, James D.

This training module on the troubleshooting of an electromechanical system, The Westinghouse Programmable Logic Controller (PLC) controlling a pneumatic robot, is used for a troubleshooting unit in an electromechanical systems/robotics and automation systems course. In this unit, students locate and repair a defect in a PLC-operated machine. The…

AUTOMOTIVE DIESEL MAINTENANCE 2. UNIT V, AUTOMATIC TRANSMISSIONS--TORQUE CONVERTER.

ERIC Educational Resources Information Center

Human Engineering Inst., Cleveland, OH.

THIS MODULE OF A 25-MODULE COURSE IS DESIGNED TO DEVELOP AN UNDERSTANDING OF THE OPERATION AND MAINTENANCE OF TORQUE CONVERTERS USED ON DIESEL POWERED VEHICLES. TOPICS ARE (1) FLUID COUPLINGS (LOCATION AND PURPOSE), (2) PRINCIPLES OF OPERATION, (3) TORQUE CONVERRS, (4) TORQMATIC CONVERTER, (5) THREE STAGE, THREE ELEMENT TORQUE CONVERTER, AND (6)…

Sampling. Operational Control Tests for Wastewater Treatment Facilities. Instructor's Manual [and] Student Workbook.

ERIC Educational Resources Information Center

Carnegie, John W.

A brief overview of the basic concepts and philosophies for sampling water and waste water systems is presented in this module. The module is not intended to specify sampling procedures, frequencies, or locations for specific treatment facilities but rather to outline those general procedures which should be followed when sampling under most…

Dynamic Sampling of Cabin VOCs during the Mission Operations Test of the Deep Space Habitat

NASA Technical Reports Server (NTRS)

Monje, Oscar; Rojdev, Kristina

2013-01-01

The atmospheric composition inside spacecraft is dynamic due to changes in crew metabolism and payload operations. A portable FTIR gas analyzer was used to monitor the atmospheric composition of four modules (Core lab, Veggie Plant Atrium, Hygiene module, and Xhab loft) within the Deep Space Habitat '(DSH) during the Mission Operations Test (MOT) conducted at the Johnson Space Center. The FTIR was either physically relocated to a new location or the plumbing was changed so that a different location was monitored. An application composed of 20 gases was used and the FTIR was zeroed using N2 gas every time it was relocated. The procedures developed for operating the FTIR were successful as all data was collected and the FTIR worked during the entire MOT mission. Not all the 20 gases in the application sampled were detected and it was possible to measure dynamic VOC concentrations in each DSH location.

Habitat Demonstration Unit (HDU) Vertical Cylinder Habitat

NASA Technical Reports Server (NTRS)

Howe, Alan; Kennedy, Kriss J.; Gill, Tracy R.; Tri, Terry O.; Toups, Larry; Howard, Robert I.; Spexarth, Gary R.; Cavanaugh, Stephen; Langford, William M.; Dorsey, John T.

2014-01-01

NASA's Constellation Architecture Team defined an outpost scenario optimized for intensive mobility that uses small, highly mobile pressurized rovers supported by portable habitat modules that can be carried between locations of interest on the lunar surface. A compact vertical cylinder characterizes the habitat concept, where the large diameter maximizes usable flat floor area optimized for a gravity environment and allows for efficient internal layout. The module was sized to fit into payload fairings for the Constellation Ares V launch vehicle, and optimized for surface transport carried by the All-Terrain Hex-Limbed Extra-Terrestrial Explorer (ATHLETE) mobility system. Launch and other loads are carried through the barrel to a top and bottom truss that interfaces with a structural support unit (SSU). The SSU contains self-leveling feet and docking interfaces for Tri-ATHLETE grasping and heavy lift. A pressurized module needed to be created that was appropriate for the lunar environment, could be easily relocated to new locations, and could be docked together in multiples for expanding pressurized volume in a lunar outpost. It was determined that horizontally oriented pressure vessels did not optimize floor area, which takes advantage of the gravity vector for full use. Hybrid hard-inflatable habitats added an unproven degree of complexity that may eventually be worked out. Other versions of vertically oriented pressure vessels were either too big, bulky, or did not optimize floor area. The purpose of the HDU vertical habitat module is to provide pressurized units that can be docked together in a modular way for lunar outpost pressurized volume expansion, and allow for other vehicles, rovers, and modules to be attached to the outpost to allow for IVA (intra-vehicular activity) transfer between them. The module is a vertically oriented cylinder with a large radius to allow for maximal floor area and use of volume. The modular, 5- m-diameter HDU vertical habitat module consists of a 2-m-high barrel with 0.6-mhigh end domes forming the 56-cubicmeter pressure vessel, and a 19-squaremeter floor area. The module has up to four docking ports located orthogonally from each other around the perimeter, and up to one docking port each on the top or bottom end domes. In addition, the module has mounting trusses top and bottom for equipment, and to allow docking with the ATHLETE mobility system. Novel or unique features of the HDU vertical habitat module include the nodelike function with multiple pressure hatches for docking with other versions of itself and other modules and vehicles; the capacity to be carried by an ATHLETE mobility system; and the ability to attach inflatable 'attic' domes to the top for additional pressurized volume.

Design and Performance Evaluation on Ultra-Wideband Time-Of-Arrival 3D Tracking System

NASA Technical Reports Server (NTRS)

Ni, Jianjun; Arndt, Dickey; Ngo, Phong; Dusl, John

2012-01-01

A three-dimensional (3D) Ultra-Wideband (UWB) Time--of-Arrival (TOA) tracking system has been studied at NASA Johnson Space Center (JSC) to provide the tracking capability inside the International Space Station (ISS) modules for various applications. One of applications is to locate and report the location where crew experienced possible high level of carbon-dioxide and felt upset. In order to accurately locate those places in a multipath intensive environment like ISS modules, it requires a robust real-time location system (RTLS) which can provide the required accuracy and update rate. A 3D UWB TOA tracking system with two-way ranging has been proposed and studied. The designed system will be tested in the Wireless Habitat Testbed which simulates the ISS module environment. In this presentation, we discuss the 3D TOA tracking algorithm and the performance evaluation based on different tracking baseline configurations. The simulation results show that two configurations of the tracking baseline are feasible. With 100 picoseconds standard deviation (STD) of TOA estimates, the average tracking error 0.2392 feet (about 7 centimeters) can be achieved for configuration Twisted Rectangle while the average tracking error 0.9183 feet (about 28 centimeters) can be achieved for configuration Slightly-Twisted Top Rectangle . The tracking accuracy can be further improved with the improvement of the STD of TOA estimates. With 10 picoseconds STD of TOA estimates, the average tracking error 0.0239 feet (less than 1 centimeter) can be achieved for configuration "Twisted Rectangle".

Directed network modules

NASA Astrophysics Data System (ADS)

Palla, Gergely; Farkas, Illés J.; Pollner, Péter; Derényi, Imre; Vicsek, Tamás

2007-06-01

A search technique locating network modules, i.e. internally densely connected groups of nodes in directed networks is introduced by extending the clique percolation method originally proposed for undirected networks. After giving a suitable definition for directed modules we investigate their percolation transition in the Erdos-Rényi graph both analytically and numerically. We also analyse four real-world directed networks, including Google's own web-pages, an email network, a word association graph and the transcriptional regulatory network of the yeast Saccharomyces cerevisiae. The obtained directed modules are validated by additional information available for the nodes. We find that directed modules of real-world graphs inherently overlap and the investigated networks can be classified into two major groups in terms of the overlaps between the modules. Accordingly, in the word-association network and Google's web-pages, overlaps are likely to contain in-hubs, whereas the modules in the email and transcriptional regulatory network tend to overlap via out-hubs.

Diffusion spectral imaging modules correlate with EEG LORETA neuroimaging modules.

PubMed

Thatcher, Robert W; North, Duane M; Biver, Carl J

2012-05-01

The purpose of this study was to test the hypothesis that the highest temporal correlations between 3-dimensional EEG current source density corresponds to anatomical Modules of high synaptic connectivity. Eyes closed and eyes open EEG was recorded from 19 scalp locations with a linked ears reference from 71 subjects age 13-42 years. LORETA was computed from 1 to 30 Hz in 2,394 cortical gray matter voxels that were grouped into six anatomical Modules corresponding to the ROIs in the Hagmann et al.'s [2008] diffusion spectral imaging (DSI) study. All possible cross-correlations between voxels within a DSI Module were compared with the correlations between Modules. The Hagmann et al. [ 2008] Module correlation structure was replicated in the correlation structure of EEG three-dimensional current source density. EEG Temporal correlation between brain regions is related to synaptic density as measured by diffusion spectral imaging. Copyright © 2011 Wiley-Liss, Inc.

Cauda equina syndrome secondary to neurolymphomatosis: Case report and literature review.

PubMed

Jiménez Zapata, Herbert Daniel; Rojas Medina, Luis Mariano; Carrasco Moro, Rodrigo; Martínez Rodrigo, Aurora; García-Cosio Piqueras, Mónica

Neurolymphomatosis is a rare disorder characterised by infiltration of neoplastic lymphocytes into the peripheral nervous system. A wide variety of symptoms can manifest depending on its nature and location, making its diagnosis a real challenge. Treatment is based on methotrexate, although various chemotherapy regimens are currently available for patients with systemic disease. We present the case of a male patient with neurolymphomatosis of the cauda equina, together with a review of all cases published to date. Copyright © 2017 Sociedad Española de Neurocirugía. Publicado por Elsevier España, S.L.U. All rights reserved.

Final design of a space debris removal system

NASA Technical Reports Server (NTRS)

Carlson, Erika; Casali, Steve; Chambers, Don; Geissler, Garner; Lalich, Andrew; Leipold, Manfred; Mach, Richard; Parry, John; Weems, Foley

1990-01-01

The objective is the removal of medium sized orbital debris in low Earth orbits. The design incorporates a transfer vehicle and a netting vehicle to capture the medium size debris. The system is based near an operational space station located at 28.5 degrees inclination and 400 km altitude. The system uses ground based tracking to determine the location of a satellite breakup or debris cloud. This data is unloaded to the transfer vehicle, and the transfer vehicle proceeds to rendezvous with the debris at a lower altitude parking orbit. Next, the netting vehicle is deployed, tracks the targeted debris, and captures it. After expending the available nets, the netting vehicle returns to the transfer vehicle for a new netting module and continues to capture more debris in the target area. Once all the netting modules are expended, the transfer vehicle returns to the space station's orbit, where it is resupplied with new netting modules from a space shuttle load. The new modules are launched by the shuttle from the ground, and the expended modules are taken back to Earth for removal of the captured debris, refueling, and repacking of the nets. Once the netting modules are refurbished, they are taken back into orbit for reuse. In a typical mission, the system has the ability to capture 50 pieces of orbital debris. One mission will take about six months. The system is designed to allow for a 30 degree inclination change on the outgoing and incoming trips of the transfer vehicle.

Final design of a space debris removal system

NASA Astrophysics Data System (ADS)

Carlson, Erika; Casali, Steve; Chambers, Don; Geissler, Garner; Lalich, Andrew; Leipold, Manfred; Mach, Richard; Parry, John; Weems, Foley

1990-12-01

The objective is the removal of medium sized orbital debris in low Earth orbits. The design incorporates a transfer vehicle and a netting vehicle to capture the medium size debris. The system is based near an operational space station located at 28.5 degrees inclination and 400 km altitude. The system uses ground based tracking to determine the location of a satellite breakup or debris cloud. This data is unloaded to the transfer vehicle, and the transfer vehicle proceeds to rendezvous with the debris at a lower altitude parking orbit. Next, the netting vehicle is deployed, tracks the targeted debris, and captures it. After expending the available nets, the netting vehicle returns to the transfer vehicle for a new netting module and continues to capture more debris in the target area. Once all the netting modules are expended, the transfer vehicle returns to the space station's orbit, where it is resupplied with new netting modules from a space shuttle load. The new modules are launched by the shuttle from the ground, and the expended modules are taken back to Earth for removal of the captured debris, refueling, and repacking of the nets. Once the netting modules are refurbished, they are taken back into orbit for reuse. In a typical mission, the system has the ability to capture 50 pieces of orbital debris. One mission will take about six months. The system is designed to allow for a 30 degree inclination change on the outgoing and incoming trips of the transfer vehicle.

Automatic Railway Traffic Object Detection System Using Feature Fusion Refine Neural Network under Shunting Mode.

PubMed

Ye, Tao; Wang, Baocheng; Song, Ping; Li, Juan

2018-06-12

Many accidents happen under shunting mode when the speed of a train is below 45 km/h. In this mode, train attendants observe the railway condition ahead using the traditional manual method and tell the observation results to the driver in order to avoid danger. To address this problem, an automatic object detection system based on convolutional neural network (CNN) is proposed to detect objects ahead in shunting mode, which is called Feature Fusion Refine neural network (FR-Net). It consists of three connected modules, i.e., the depthwise-pointwise convolution, the coarse detection module, and the object detection module. Depth-wise-pointwise convolutions are used to improve the detection in real time. The coarse detection module coarsely refine the locations and sizes of prior anchors to provide better initialization for the subsequent module and also reduces search space for the classification, whereas the object detection module aims to regress accurate object locations and predict the class labels for the prior anchors. The experimental results on the railway traffic dataset show that FR-Net achieves 0.8953 mAP with 72.3 FPS performance on a machine with a GeForce GTX1080Ti with the input size of 320 × 320 pixels. The results imply that FR-Net takes a good tradeoff both on effectiveness and real time performance. The proposed method can meet the needs of practical application in shunting mode.

Modulation selection for visible light communications using lighting LEDs

NASA Astrophysics Data System (ADS)

Siuzdak, Jerzy

2015-09-01

The paper analyzes suitability of various spectrally efficient modulations (PAM, CAP, OFDM/DMT) in a VLC system using lighting LEDs as a transmitter. Although under ideal conditions all modulation have similar efficiency i.e. they produce similar throughputs with a given BER, their practical performances are different. For example, the level of nonlinear distortions generated by each modulation is the least for PAM and by far the greatest for OFDM/DMT locating CAP in the middle. The suitability of various OFDM/DMT variants in a VLC LED link was also analyzed proving that the asymmetrically clipped (ACO) OFDM has a worse performance as compared with DC biased (DCO) OFDM.

Hand-arm vibration exposure monitoring with wearable sensor module.

PubMed

Austad, Hanne O; Røed, Morten H; Liverud, Anders E; Dalgard, Steffen; Seeberg, Trine M

2013-01-01

Vibration exposure is a serious risk within work physiology for several work groups. Combined with cold artic climate, the risk for permanent harm is even higher. Equipment that can monitor the vibration exposure and warn the user when at risk will provide a safer work environment for these work groups. This study evaluates whether data from a wearable wireless multi-parameter sensor module can be used to estimate vibration exposure and exposure time. This work has been focused on the characterization of the response from the accelerometer in the sensor module and the optimal location of the module in the hand-arm configuration.

Interpreting fMRI data: maps, modules and dimensions

PubMed Central

Op de Beeck, Hans P.; Haushofer, Johannes; Kanwisher, Nancy G.

2009-01-01

Neuroimaging research over the past decade has revealed a detailed picture of the functional organization of the human brain. Here we focus on two fundamental questions that are raised by the detailed mapping of sensory and cognitive functions and illustrate these questions with findings from the object-vision pathway. First, are functionally specific regions that are located close together best understood as distinct cortical modules or as parts of a larger-scale cortical map? Second, what functional properties define each cortical map or module? We propose a model in which overlapping continuous maps of simple features give rise to discrete modules that are selective for complex stimuli. PMID:18200027

Annexin A1 influences in breast cancer: Controversies on contributions to tumour, host and immunoediting processes.

PubMed

Tu, Yan; Johnstone, Cameron N; Stewart, Alastair G

2017-05-01

Annexin A1 is a multifunctional protein characterised by its actions in modulating the innate and adaptive immune response. Accumulating evidence of altered annexin A1 expression in many human tumours raises interest in its functional role in cancer biology. In breast cancer, altered annexin A1 expression levels suggest a potential influence on tumorigenic and metastatic processes. However, reports of conflicting results reveal a relationship that is much more complex than first conceptualised. In this review, we explore the diverse actions of annexin A1 on breast tumour cells and various host cell types, including stromal immune and structural cells, particularly in the context of cancer immunoediting. Copyright © 2017 Elsevier Ltd. All rights reserved.

Gut microbiota and obesity: role in aetiology and potential therapeutic target.

PubMed

Moran, Carthage P; Shanahan, Fergus

2014-08-01

Obesity is epidemic; chronic energy surplus is clearly important in obesity development but other factors are at play. Indigenous gut microbiota are implicated in the aetiopathogenesis of obesity and obesity-related disorders. Evidence from murine models initially suggested a role for the gut microbiota in weight regulation and the microbiota has been shown to contribute to the low grade inflammation that characterises obesity. The microbiota and its metabolites mediate some of the alterations of the microbiota-gut-brain axis, the endocannabinoid system, and bile acid metabolism, found in obesity-related disorders. Modulation of the gut microbiota is an attractive proposition for prevention or treatment of obesity, particularly as traditional measures have been sub-optimal. Copyright © 2014 Elsevier Ltd. All rights reserved.

One-dimensional, two-dimensional, and three-dimensional photonic crystals fabricated with interferometric techniques on ultrafine-grain silver halide emulsions

NASA Astrophysics Data System (ADS)

Ulibarrena, Manuel; Carretero, Luis; Acebal, Pablo; Madrigal, Roque; Blaya, Salvador; Fimia, Antonio

2004-09-01

Holographic techniques have been used for manufacturing multiple band one-dimensional, two-dimensional, and three-dimensional photonic crystals with different configurations, by multiplexing reflection and transmission setups on a single layer of holographic material. The recording material used for storage is an ultra fine grain silver halide emulsion, with an average grain size around 20 nm. The results are a set of photonic crystals with the one-dimensional, two-dimensional, and three-dimensional index modulation structure consisting of silver halide particles embedded in the gelatin layer of the emulsion. The characterisation of the fabricated photonic crystals by measuring their transmission band structures has been done and compared with theoretical calculations.

Parallel-Connected Photovoltaic Inverters: Zero Frequency Sequence Harmonic Analysis and Solution

NASA Astrophysics Data System (ADS)

Carmeli, Maria Stefania; Mauri, Marco; Frosio, Luisa; Bezzolato, Alberto; Marchegiani, Gabriele

2013-05-01

High-power photovoltaic (PV) plants are usually constituted of the connection of different PV subfields, each of them with its interface transformer. Different solutions have been studied to improve the efficiency of the whole generation system. In particular, transformerless configurations are the more attractive one from efficiency and costs point of view. This paper focuses on transformerless PV configurations characterised by the parallel connection of interface inverters. The problem of zero sequence current due to both the parallel connection and the presence of undesirable parasitic earth capacitances is considered and a solution, which consists of the synchronisation of pulse-width modulation triangular carrier, is proposed and theoretically analysed. The theoretical analysis has been validated through simulation and experimental results.

Fraxinus paxiana bark mediated photosynthesis of silver nanoparticles and their size modulation using swift heavy ion irradiation

NASA Astrophysics Data System (ADS)

Sharma, Hemant; Vendamani, V. S.; Pathak, Anand P.; Tiwari, Archana

2015-12-01

Photosynthesis of silver nanoparticles is presented using bark extracts of Fraxinus paxiana var. sikkimensis. The synthesized nanoparticles are characterised by UV-Vis absorption, photoluminescence, powder X-ray diffraction and scanning and transmission electron microscopy. In addition, the bark samples are irradiated with 100 MeV silver ions and the subsequent structural modifications are analyzed. The swift heavy ion irradiated Fraxinus paxiana var. sikkimensis bark is also used for the synthesis of silver nanoparticles. It is illustrated that the irradiated bark assists in synthesizing smaller nanoparticles of homogenous size distribution as compared to when the pristine bark is used. The newly synthesized silver nanoparticles are also used to demonstrate the antimicrobial activities on Escherichia coli bacteria.

Capsule Design for Blue Light Therapy against Helicobacter pylori.

PubMed

Li, Zhangyong; Ren, Binbin; Tan, Haiyan; Liu, Shengrong; Wang, Wei; Pang, Yu; Lin, Jinzhao; Zeng, Chen

2016-01-01

A photo-medical capsule that emits blue light for Helicobacter pylori treatment was described in this paper. The system consists of modules for pH sensing and measuring, light-emitting diode driver circuit, radio communication and microcontroller, and power management. The system can differentiate locations by monitoring the pH values of the gastrointestinal tract, and turn on and off the blue light according to the preset range of pH values. Our experimental tests show that the capsule can operate in the effective light therapy mode for more than 32 minutes and the wireless communication module can reliably transmit the measured pH value to a receiver located outside the body.

Floristic and phytosociology in dense "terra firme" rainforest in the Belo Monte Hydroelectric Plant influence area, Pará, Brazil.

PubMed

Lemos, D A N; Ferreira, B G A; Siqueira, J D P; Oliveira, M M; Ferreira, A M

2015-08-01

The objective of the present study was to characterise the floristic and phytosociological composition on a stretch of dense "Terra Firme" rainforest located in the Belo Monte hydroelectric plant area of influence, located in the state of Pará, Brazil. All trees with DAP >10 cm situated in 75 permanent plots of 1 ha were inventoried. 27,126 individuals trees (361 ind.ha-1), distributed in 59 botanical families, comprising 481 species were observed. The families with the largest number of species were Fabaceae (94), Araceae (65) and Arecaceae (43), comprising 43.7% of total species. The species Alexa grandiflora (4.41), Cenostigma tocantinum (2.50) and Bertholletia excelsa (2.28) showed the highest importance values (IV). The ten species with greater IV are concentrated (22%). The forest community has high species richness and can be classified as diverse age trees, heterogeneous and of medium conservation condition.

Application of Time-Domain Electromagnetic Method in Investigating Saltwater Intrusion of Santiago Island (Cape Verde)

NASA Astrophysics Data System (ADS)

Gonçalves, Rui; Farzamian, Mohammad; Monteiro Santos, Fernando A.; Represas, Patrícia; Mota Gomes, A.; Lobo de Pina, A. F.; Almeida, Eugénio P.

2017-11-01

Santiago Island, the biggest and most populated island of the Cape Verde Republic, is characterised by limited surface waters and strong dependence on groundwater sources as the primary source of natural water supply for extensive agricultural activity and human use. However, as a consequence of the scarce precipitation and high evaporation as well as the intense overexploitation of the groundwater resources, the freshwater management is also in a delicate balance with saltwater at coastal areas. The time-domain electromagnetic (TDEM) method is used to locate the extent of saltwater intrusion in four important agricultural regions in Santiago Island; São Domingos, Santa Cruz, São Miguel, and Tarrafal. The application of this method in Santiago Island proves it to be a successful tool in imaging the fresh/saltwater interface location. Depths to the saline zones and extensions of saline water are mapped along eight TDEM profiles.

Linkage analysis in Usher syndrome type I (USH1) families from Spain.

PubMed Central

Espinós, C; Nájera, C; Millán, J M; Ayuso, C; Baiget, M; Pérez-Garrigues, H; Rodrigo, O; Vilela, C; Beneyto, M

1998-01-01

Usher syndrome (USH) is an autosomal recessive hereditary disorder characterised by congenital sensorineural hearing loss and gradual visual impairment secondary to retinitis pigmentosa (RP). The disorder is clinically and genetically heterogeneous. With regard to Usher type I (USH1), several subtypes have been described, the most frequent being USH1B located on chromosome 11q13.5. Of 18 USH1 families studied by linkage analysis, 12 (67%) showed significant lod score values for locus D11S527 (Zmax=14.032, theta=0.000) situated on chromosome 11q. Our findings suggest considerable genetic heterogeneity in the Spanish USH1 population. It is important to note that one of our families linked to the USH1B locus shows interesting intrafamilial clinical variability. As regards the remaining six USH1 families, the linkage analysis did not provide conclusive data, although two of them show slight linkage to markers located on chromosome 3q (Zmax=1.880, theta=0.000 for D3S1279), the same location that had previously been assigned to some USH3 families. Images PMID:9610802

Urban retail location: Insights from percolation theory and spatial interaction modeling

PubMed Central

Molinero, Carlos; Wilson, Alan

2017-01-01

Characterising road networks has been the focus of a large body of research due to it being the main driver of activities in an urban ecosystem and the structuring factor in the dynamics of the city. One of these activities, and one with the largest economical impact in a city, is retail dynamics and its evolution. Therefore, the mathematical modeling of the location of retail activities and of the emergence of clustering in retail centers has as well generated a large number of works. Despite these two interwoven components strongly depending on one another and their fundamental importance in understanding cities, little work has been done in order to compare their local and global properties. Here we compare the road network’s hierarchical structure, unveiled through a percolation analysis of the network, with the retail location distribution defined by exploiting a gravity-based retail model. We interpret the great agreement in the city’s organizations as it emerges from both methodologies as new evidence of the interdependence of these two crucial dimensions of a city’s life. PMID:28977032

Urban retail location: Insights from percolation theory and spatial interaction modeling.

PubMed

Piovani, Duccio; Molinero, Carlos; Wilson, Alan

2017-01-01

Characterising road networks has been the focus of a large body of research due to it being the main driver of activities in an urban ecosystem and the structuring factor in the dynamics of the city. One of these activities, and one with the largest economical impact in a city, is retail dynamics and its evolution. Therefore, the mathematical modeling of the location of retail activities and of the emergence of clustering in retail centers has as well generated a large number of works. Despite these two interwoven components strongly depending on one another and their fundamental importance in understanding cities, little work has been done in order to compare their local and global properties. Here we compare the road network's hierarchical structure, unveiled through a percolation analysis of the network, with the retail location distribution defined by exploiting a gravity-based retail model. We interpret the great agreement in the city's organizations as it emerges from both methodologies as new evidence of the interdependence of these two crucial dimensions of a city's life.

Comprehensive characterisation of groundwater quality in and around a landfill area for agricultural suitability

NASA Astrophysics Data System (ADS)

Hariharan, V.; Chilambarasan, L.; Nandhakumar, G.; Porchelvan, P.

2017-11-01

Groundwater contamination has become so alarming that the existing valuable freshwater resources are at stake. Landfilling of solid refuse without pre-emptive measures, over the years, leads to the utter depletion of the groundwater quality in its vicinity. The Kodungaiyur landfill at the Perambur taluk located in the northernmost region of the Chennai metropolitan, is such a poorly managed landfill. This research article is intended to exhibit a detailed study report on the physicochemical and bacteriological parametric analyses of the currently available subsurface water in and around the landfill area. Besides being evident from the faecal coliform test that the water is not potable, the chief objective was to investigate the suitability of groundwater for irrigation. Representative samples of groundwater were collected from inside the landfill site, and the residential areas located within 2 km from the site and analysed using standard methods. The test results were interpreted by employing exhaustive statistical approaches. It is evident to the interpretations that, out of the nine sampled locations, seven were found to be endowed with a groundwater quality fit enough for irrigation.

In-situ comparison of thermal measurement technologies for interpretation of PV module temperature de-rating effects

NASA Astrophysics Data System (ADS)

Elwood, Teri; Bennett, Whit; Lai, Teh; Simmons-Potter, Kelly

2016-09-01

It is well known that the efficiency of a photovoltaic (PV) module is strongly impacted by its temperature such that higher temperatures lead to lower energy conversion efficiencies. An accurate measurement of the temperature de-rating effect, therefore, is vital to the correct interpretation of PV module performance under varied environmental conditions. The current work investigates and compares methods for performing measurements of module temperature both in the lab and in field-test environments. A comparison of several temperature measurement devices was made in order to establish the ideal sensor configuration for quantifying module operating temperature. Sensors were also placed in various locations along a string of up to eight photovoltaic modules to examine the variance in operating temperature with position in the string and within a larger array of strings.

Large Advanced Space Systems (LASS) computer-aided design program additions

NASA Technical Reports Server (NTRS)

Farrell, C. E.

1982-01-01

The LSS preliminary and conceptual design requires extensive iteractive analysis because of the effects of structural, thermal, and control intercoupling. A computer aided design program that will permit integrating and interfacing of required large space system (LSS) analyses is discussed. The primary objective of this program is the implementation of modeling techniques and analysis algorithms that permit interactive design and tradeoff studies of LSS concepts. Eight software modules were added to the program. The existing rigid body controls module was modified to include solar pressure effects. The new model generator modules and appendage synthesizer module are integrated (interfaced) to permit interactive definition and generation of LSS concepts. The mass properties module permits interactive specification of discrete masses and their locations. The other modules permit interactive analysis of orbital transfer requirements, antenna primary beam n, and attitude control requirements.

Locating the Business. PACE Revised. Level 2. Unit 7. Research & Development Series No. 240BB7.

ERIC Educational Resources Information Center

Ashmore, M. Catherine; Pritz, Sandra G.

This unit on selecting a site for a small business, the seventh in a series of 18 modules, is on the second level of the revised PACE (Program for Acquiring Competence in Entrepreneurship) comprehensive curriculum. Geared to advanced secondary and beginning postsecondary or adult students, the modules provide an opportunity to learn about and try…

Land Application of Wastes: An Educational Program. Case Studies Reviewed - Module 14.

ERIC Educational Resources Information Center

Clarkson, W. W.; And Others

This module provides information about 14 existing land application systems. Each case study gives the location and description of the system, volume treated, climate and soil type, cost, land area, and other data. A brief comment about the system is given as well as a more detailed discussion. References are cited which may be used to examine 100…

Attention modulates maintenance of representations in visual short-term memory.

PubMed

Kuo, Bo-Cheng; Stokes, Mark G; Nobre, Anna Christina

2012-01-01

Recent studies have shown that selective attention is of considerable importance for encoding task-relevant items into visual short-term memory (VSTM) according to our behavioral goals. However, it is not known whether top-down attentional biases can continue to operate during the maintenance period of VSTM. We used ERPs to investigate this question across two experiments. Specifically, we tested whether orienting attention to a given spatial location within a VSTM representation resulted in modulation of the contralateral delay activity (CDA), a lateralized ERP marker of VSTM maintenance generated when participants selectively encode memory items from one hemifield. In both experiments, retrospective cues during the maintenance period could predict a specific item (spatial retrocue) or multiple items (neutral retrocue) that would be probed at the end of the memory delay. Our results revealed that VSTM performance is significantly improved by orienting attention to the location of a task-relevant item. The behavioral benefit was accompanied by modulation of neural activity involved in VSTM maintenance. Spatial retrocues reduced the magnitude of the CDA, consistent with a reduction in memory load. Our results provide direct evidence that top-down control modulates neural activity associated with maintenance in VSTM, biasing competition in favor of the task-relevant information.

Understanding allosteric interactions in G protein-coupled receptors using Supervised Molecular Dynamics: A prototype study analysing the human A3 adenosine receptor positive allosteric modulator LUF6000.

PubMed

Deganutti, Giuseppe; Cuzzolin, Alberto; Ciancetta, Antonella; Moro, Stefano

2015-07-15

The search for G protein-coupled receptors (GPCRs) allosteric modulators represents an active research field in medicinal chemistry. Allosteric modulators usually exert their activity only in the presence of the orthosteric ligand by binding to protein sites topographically different from the orthosteric cleft. They therefore offer potentially therapeutic advantages by selectively influencing tissue responses only when the endogenous agonist is present. The prediction of putative allosteric site location, however, is a challenging task. In facts, they are usually located in regions showing more structural variation among the family members. In the present work, we applied the recently developed Supervised Molecular Dynamics (SuMD) methodology to interpret at the molecular level the positive allosteric modulation mediated by LUF6000 toward the human adenosine A3 receptor (hA3 AR). Our data suggest at least two possible mechanisms to explain the experimental data available. This study represent, to the best of our knowledge, the first case reported of an allosteric recognition mechanism depicted by means of molecular dynamics simulations. Copyright © 2015 Elsevier Ltd. All rights reserved.

The Multisensory Attentional Consequences of Tool Use: A Functional Magnetic Resonance Imaging Study

PubMed Central

Holmes, Nicholas P.; Spence, Charles; Hansen, Peter C.; Mackay, Clare E.; Calvert, Gemma A.

2008-01-01

Background Tool use in humans requires that multisensory information is integrated across different locations, from objects seen to be distant from the hand, but felt indirectly at the hand via the tool. We tested the hypothesis that using a simple tool to perceive vibrotactile stimuli results in the enhanced processing of visual stimuli presented at the distal, functional part of the tool. Such a finding would be consistent with a shift of spatial attention to the location where the tool is used. Methodology/Principal Findings We tested this hypothesis by scanning healthy human participants' brains using functional magnetic resonance imaging, while they used a simple tool to discriminate between target vibrations, accompanied by congruent or incongruent visual distractors, on the same or opposite side to the tool. The attentional hypothesis was supported: BOLD response in occipital cortex, particularly in the right hemisphere lingual gyrus, varied significantly as a function of tool position, increasing contralaterally, and decreasing ipsilaterally to the tool. Furthermore, these modulations occurred despite the fact that participants were repeatedly instructed to ignore the visual stimuli, to respond only to the vibrotactile stimuli, and to maintain visual fixation centrally. In addition, the magnitude of multisensory (visual-vibrotactile) interactions in participants' behavioural responses significantly predicted the BOLD response in occipital cortical areas that were also modulated as a function of both visual stimulus position and tool position. Conclusions/Significance These results show that using a simple tool to locate and to perceive vibrotactile stimuli is accompanied by a shift of spatial attention to the location where the functional part of the tool is used, resulting in enhanced processing of visual stimuli at that location, and decreased processing at other locations. This was most clearly observed in the right hemisphere lingual gyrus. Such modulations of visual processing may reflect the functional importance of visuospatial information during human tool use. PMID:18958150

STS-96 crew takes part in payload Interface Verification Test

NASA Technical Reports Server (NTRS)

1999-01-01

In the SPACEHAB Facility, the STS-96 crew looks at equipment as part of a payload Interface Verification Test (IVT) for their upcoming mission to the International Space Station . From left are Mission Specialist Ellen Ochoa (behind the opened storage cover ), Commander Kent Rominger, Pilot Rick Husband (holding a lithium hydroxide canister) and Mission Specialists Dan Barry, Valery Tokarev of Russia and Julie Payette. In the background is TTI interpreter Valentina Maydell. The other crew member at KSC for the IVT is Mission Specialist Tamara Jernigan. Mission STS-96 carries the SPACEHAB Logistics Double Module, which has equipment to further outfit the International Space Station service module and equipment that can be off-loaded from the early U.S. assembly flights. The SPACEHAB carries internal logistics and resupply cargo for station outfitting, plus an external Russian cargo crane to be mounted to the exterior of the Russian station segment and used to perform space walking maintenance activities. The double module stowage provides capacity of up to 10,000 lbs. with the ability to accommodate powered payloads, four external rooftop stowage locations, four double-rack locations (two powered), up to 61 bulkhead-mounted middeck locker locations, and floor storage for large unique items and Soft Stowage. STS-96 is targeted to launch May 20 about 9:32 a.m.

STS-96 crew takes part in payload Interface Verification Test

NASA Technical Reports Server (NTRS)

1999-01-01

In the SPACEHAB Facility, STS-96 crew members look over equipment during a payload Interface Verification Test (IVT) for their upcoming mission to the International Space Station. From left are Khristal Parker, with Boeing; Mission Specialist Dan Barry, Pilot Rick Husband, Mission Specialist Tamara Jernigan, and at the far right, Mission Specialist Julie Payette. An unidentified worker is in the background. Also at KSC for the IVT are Commander Kent Rominger and Mission Specialists Ellen Ochoa and Valery Tokarev of Russia. Mission STS-96 carries the SPACEHAB Logistics Double Module, which will have equipment to further outfit the International Space Station service module and equipment that can be off-loaded from the early U.S. assembly flights. It carries internal logistics and resupply cargo for station outfitting, plus an external Russian cargo crane to be mounted to the exterior of the Russian station segment and used to perform space walking maintenance activities. The double module stowage provides capacity of up to 10,000 lbs. with the ability to accommodate powered payloads, four external rooftop stowage locations, four double-rack locations (two powered), up to 61 bulkhead-mounted middeck locker locations, and floor storage for large unique items and Soft Stowage. STS-96 is targeted to launch May 20 about 9:32 a.m.

STS-96 crew takes part in payload Interface Verification Test

NASA Technical Reports Server (NTRS)

1999-01-01

In the SPACEHAB Facility, (left to right) STS-96 Pilot Rick Husband and Mission Specialists Julie Payette and Ellen Ochoa work the straps on the Sequential Shunt Unit (SSU) in front of them. The STS-96 crew is at KSC for a payload Interface Verification Test (IVT) for its upcoming mission to the International Space Station . Other crew members at KSC for the IVT are Commander Kent Rominger and Mission Specialists Tamara Jernigan, Dan Barry and Valery Tokarev of Russia. The SSU is part of the cargo on Mission STS-96, which carries the SPACEHAB Logistics Double Module, with equipment to further outfit the International Space Station service module and equipment that can be off-loaded from the early U.S. assembly flights. The SPACEHAB carries internal logistics and resupply cargo for station outfitting, plus an external Russian cargo crane to be mounted to the exterior of the Russian station segment and used to perform space walking maintenance activities. The double module stowage provides capacity of up to 10,000 lbs. with the ability to accommodate powered payloads, four external rooftop stowage locations, four double-rack locations (two powered), up to 61 bulkhead-mounted middeck locker locations, and floor storage for large unique items and Soft Stowage. STS-96 is targeted to launch May 20 about 9:32 a.m.

STS-96 crew takes part in payload Interface Verification Test

NASA Technical Reports Server (NTRS)

1999-01-01

In the SPACEHAB Facility, STS-96 Mission Specialist Valery Tokarev of Russia (left) and Commander Kent Rominger (second from right) listen to Lynn Ashby (far right), with JSC, talking about the SPACEHAB equipment in front of them during a payload Interface Verification Test (IVT). In the background behind Tokarev is TTI interpreter Valentina Maydell. Other STS-96 crew members at KSC for the IVT are Pilot Rick Husband and Mission Specialists Dan Barry, Ellen Ochoa, Tamara Jernigan and Julie Payette. Mission STS-96 carries the SPACEHAB Logistics Double Module, which will have equipment to further outfit the International Space Station service module and equipment that can be off-loaded from the early U.S. assembly flights. It carries internal logistics and resupply cargo for station outfitting, plus an external Russian cargo crane to be mounted to the exterior of the Russian station segment and used to perform space walking maintenance activities. The double module stowage provides capacity of up to 10,000 lbs. with the ability to accommodate powered payloads, four external rooftop stowage locations, four double-rack locations (two powered), up to 61 bulkhead-mounted middeck locker locations, and floor storage for large unique items and Soft Stowage. STS-96 is targeted to launch May 20 about 9:32 a.m.

STS-96 crew takes part in payload Interface Verification Test

NASA Technical Reports Server (NTRS)

1999-01-01

During a payload Interface Verification Test (IVT) in the SPACEHAB Facility, STS-96 Mission Specialist Valery Tokarev of Russia (second from left) and Commander Kent Rominger learn about the Sequential Shunt Unit (SSU) in front of them from Lynn Ashby (far right), with Johnson Space Center. At the far left looking on is TTI interpreter Valentina Maydell. Other crew members at KSC for the IVT are Pilot Rick Husband and Mission Specialists Ellen Ochoa, Tamara Jernigan, Dan Barry and Julie Payette. The SSU is part of the cargo on Mission STS-96, which carries the SPACEHAB Logistics Double Module, with equipment to further outfit the International Space Station service module and equipment that can be off-loaded from the early U.S. assembly flights. The SPACEHAB carries internal logistics and resupply cargo for station outfitting, plus an external Russian cargo crane to be mounted to the exterior of the Russian station segment and used to perform space walking maintenance activities. The double module stowage provides capacity of up to 10,000 lbs. with the ability to accommodate powered payloads, four external rooftop stowage locations, four double-rack locations (two powered), up to 61 bulkhead-mounted middeck locker locations, and floor storage for large unique items and Soft Stowage. STS-96 is targeted to launch May 20 about 9:32 a.m.

STS-96 crew takes part in payload Interface Verification Test

NASA Technical Reports Server (NTRS)

1999-01-01

During a payload Interface Verification Test (IVT) in the SPACEHAB Facility, STS-96 Mission Specialist Tamara Jernigan checks over instructions while Mission Specialist Dan Barry looks up from the Sequential Shunt Unit (SSU) in front of him to other equipment Lynn Ashby (right), with Johnson Space Center, is pointing at. Other crew members at KSC for the IVT are Commander Kent Rominger, Pilot Rick Husband, and Mission Specialists Ellen Ochoa, Julie Payette and Valery Tokarev of Russia. The SSU is part of the cargo on Mission STS-96, which carries the SPACEHAB Logistics Double Module, with equipment to further outfit the International Space Station service module and equipment that can be off-loaded from the early U.S. assembly flights. The SPACEHAB carries internal logistics and resupply cargo for station outfitting, plus an external Russian cargo crane to be mounted to the exterior of the Russian station segment and used to perform space walking maintenance activities. The double module stowage provides capacity of up to 10,000 lbs. with the ability to accommodate powered payloads, four external rooftop stowage locations, four double-rack locations (two powered), up to 61 bulkhead-mounted middeck locker locations, and floor storage for large unique items and Soft Stowage. STS-96 is targeted to launch May 20 about 9:32 a.m.

STS-96 crew takes part in payload Interface Verification Test

NASA Technical Reports Server (NTRS)

1999-01-01

During a payload Interface Verification Test (IVT) in the SPACEHAB Facility, STS-96 Pilot Rick Husband and Mission Specialist Ellen Ochoa (on the left) and Mission Specialist Julie Payette (on the far right) listen to Khristal Parker (second from right), with Boeing, explain about the equipment in front of them. Other crew members at KSC for the IVT are Commander Kent Rominger and Mission Specialists Tamara Jernigan, Dan Barry and Valery Tokarev of Russia. The SSU is part of the cargo on Mission STS-96, which carries the SPACEHAB Logistics Double Module, with equipment to further outfit the International Space Station service module and equipment that can be off-loaded from the early U.S. assembly flights. The SPACEHAB carries internal logistics and resupply cargo for station outfitting, plus an external Russian cargo crane to be mounted to the exterior of the Russian station segment and used to perform space walking maintenance activities. The double module stowage provides capacity of up to 10,000 lbs. with the ability to accommodate powered payloads, four external rooftop stowage locations, four double-rack locations (two powered), up to 61 bulkhead-mounted middeck locker locations, and floor storage for large unique items and Soft Stowage. STS-96 is targeted to launch May 20 about 9:32 a.m.

STS-96 crew takes part in payload Interface Verification Test

NASA Technical Reports Server (NTRS)

1999-01-01

In the SPACEHAB Facility for a payload Interface Verification Test (IVT) for their upcoming mission to the International Space Station are (kneeling) STS-96 Mission Specialists Julie Payette and Ellen Ochoa, Pilot Rick Husband, and (standing at right) Mission Specialist Dan Barry. At the left is James Behling, with Boeing, explaining some of the equipment that will be on board STS-96. Other STS-96 crew members at KSC for the IVT are Commander Kent Rominger and Mission Specialists Tamara Jernigan and Valery Tokarev of Russia. Mission STS-96 carries the SPACEHAB Logistics Double Module, which will have equipment to further outfit the International Space Station service module and equipment that can be off-loaded from the early U.S. assembly flights. It carries internal logistics and resupply cargo for station outfitting, plus an external Russian cargo crane to be mounted to the exterior of the Russian station segment and used to perform space walking maintenance activities. The double module stowage provides capacity of up to 10,000 lbs. with the ability to accommodate powered payloads, four external rooftop stowage locations, four double-rack locations (two powered), up to 61 bulkhead-mounted middeck locker locations, and floor storage for large unique items and Soft Stowage. STS-96 is targeted to launch May 20 about 9:32 a.m.

KSC-99pd0209

NASA Image and Video Library

1999-02-11

KENNEDY SPACE CENTER, FLA. -- In the SPACEHAB Facility, the STS-96 crew looks at equipment as part of a payload Interface Verification Test (IVT) for their upcoming mission to the International Space Station . From left are Mission Specialist Ellen Ochoa (behind the opened storage cover ), Commander Kent Rominger, Pilot Rick Husband (holding a lithium hydroxide canister) and Mission Specialists Dan Barry, Valery Tokarev of Russia and Julie Payette. In the background is TTI interpreter Valentina Maydell. The other crew member at KSC for the IVT is Mission Specialist Tamara Jernigan. Mission STS-96 carries the SPACEHAB Logistics Double Module, which has equipment to further outfit the International Space Station service module and equipment that can be off-loaded from the early U.S. assembly flights. The SPACEHAB carries internal logistics and resupply cargo for station outfitting, plus an external Russian cargo crane to be mounted to the exterior of the Russian station segment and used to perform space walking maintenance activities. The double module stowage provides capacity of up to 10,000 lbs. with the ability to accommodate powered payloads, four external rooftop stowage locations, four double-rack locations (two powered), up to 61 bulkhead-mounted middeck locker locations, and floor storage for large unique items and Soft Stowage. STS-96 is targeted to launch May 20 about 9:32 a.m

KSC-99pp0201

NASA Image and Video Library

1999-02-11

KENNEDY SPACE CENTER, FLA. -- In the SPACEHAB Facility, STS-96 Mission Specialist Valery Tokarev of Russia (left) and Commander Kent Rominger (second from right) listen to Lynn Ashby (far right), with JSC, talking about the SPACEHAB equipment in front of them during a payload Interface Verification Test (IVT). In the background behind Tokarev is TTI interpreter Valentina Maydell. Other STS-96 crew members at KSC for the IVT are Pilot Rick Husband and Mission Specialists Dan Barry, Ellen Ochoa, Tamara Jernigan and Julie Payette. Mission STS-96 carries the SPACEHAB Logistics Double Module, which will have equipment to further outfit the International Space Station service module and equipment that can be off-loaded from the early U.S. assembly flights. It carries internal logistics and resupply cargo for station outfitting, plus an external Russian cargo crane to be mounted to the exterior of the Russian station segment and used to perform space walking maintenance activities. The double module stowage provides capacity of up to 10,000 lbs. with the ability to accommodate powered payloads, four external rooftop stowage locations, four double-rack locations (two powered), up to 61 bulkhead-mounted middeck locker locations, and floor storage for large unique items and Soft Stowage. STS-96 is targeted to launch May 20 about 9:32 a.m

KSC-99pd0214

NASA Image and Video Library

1999-02-11

KENNEDY SPACE CENTER, FLA. -- During a payload Interface Verification Test (IVT) in the SPACEHAB Facility, STS-96 Mission Specialist Valery Tokarev of Russia (second from left) and Commander Kent Rominger learn about the Sequential Shunt Unit (SSU) in front of them from Lynn Ashby (far right), with Johnson Space Center. At the far left looking on is TTI interpreter Valentina Maydell. Other crew members at KSC for the IVT are Pilot Rick Husband and Mission Specialists Ellen Ochoa, Tamara Jernigan, Dan Barry and Julie Payette. The SSU is part of the cargo on Mission STS-96, which carries the SPACEHAB Logistics Double Module, with equipment to further outfit the International Space Station service module and equipment that can be off-loaded from the early U.S. assembly flights. The SPACEHAB carries internal logistics and resupply cargo for station outfitting, plus an external Russian cargo crane to be mounted to the exterior of the Russian station segment and used to perform space walking maintenance activities. The double module stowage provides capacity of up to 10,000 lbs. with the ability to accommodate powered payloads, four external rooftop stowage locations, four double-rack locations (two powered), up to 61 bulkhead-mounted middeck locker locations, and floor storage for large unique items and Soft Stowage. STS-96 is targeted to launch May 20 about 9:32 a.m

Characterisation of Central-African emissions based on MAX-DOAS measurements, satellite observations and model simulations over Bujumbura, Burundi.

NASA Astrophysics Data System (ADS)

Gielen, Clio; Hendrick, Francois; Pinardi, Gaia; De Smedt, Isabelle; Stavrakou, Trissevgeni; Yu, Huan; Fayt, Caroline; Hermans, Christian; Bauwens, Maité; Ndenzako, Eugene; Nzohabonayo, Pierre; Akimana, Rachel; Niyonzima, Sébastien; Müller, Jean-Francois; Van Roozendael, Michel

2016-04-01

Central Africa is known for its strong biogenic, pyrogenic, and to a lesser extent anthropogenic emissions. Satellite observations of species like nitrogen dioxide (NO2) and formaldehyde (HCHO), as well as inverse modelling results have shown that there are large uncertainties associated with the emissions in this region. There is thus a need for additional measurements, especially from the ground, in order to better characterise the biomass-burning and biogenic products emitted in this area. We present MAX-DOAS measurements of NO2, HCHO, and aerosols performed in Central Africa, in the city of Bujumbura, Burundi (3°S, 29°E, 850m). A MAX-DOAS instrument has been operating at this location by BIRA-IASB since late 2013. Aerosol-extinction and trace-gases vertical profiles are retrieved by applying the optimal-estimation-based profiling tool bePRO to the measured O4, NO2 and HCHO slant-column densities. The MAX-DOAS vertical columns and profiles are used for investigating the diurnal and seasonal cycles of NO2, HCHO, and aerosols. Regarding the aerosols, the retrieved AODs are compared to co-located AERONET sun photometer measurements for verification purpose, while in the case of NO2 and HCHO, the MAX-DOAS vertical columns and profiles are used for validating GOME-2 and OMI satellite observations. To characterise the biomass-burning and biogenic emissions in the Bujumbura region, the trace gases and aerosol MAX-DOAS retrievals are used in combination to MODIS fire counts/radiative-power and GOME-2/OMI NO2 and HCHO satellite data, as well as simulations from the NOAA backward trajectory model HYSPLIT. First results show that HCHO seasonal variation around local noon is driven by the alternation of rain and dry periods, the latter being associated with intense biomass-burning agricultural activities and forest fires in the south/south-east and transport from this region to Bujumbura. In contrast, NO2 is seen to depend mainly on local emissions close to the city, due to the short lifetime of this species (typically 1-2 hours). Regarding the biogenic emissions, it is found that they play only a minor role in the observed HCHO seasonality. These results are further assessed using the tropospheric 3D-CTM IMAGES.

First search for a dark matter annual modulation signal with NaI(Tl) in the Southern Hemisphere by DM-Ice17

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barbosa de Souza, E.; Cherwinka, J.; Cole, A.

The first search for a dark matter annual modulation signal with NaI(Tl) target material in the Southern Hemisphere conducted with the DM-Ice17 experiment is presented. DM-Ice17 consists of 17 kg of NaI(Tl) scintillating crystal under 2200 m.w.e. overburden of Antarctic glacial ice. The analysis presented here utilizes a 60.8 kg yr exposure. While unable to exclude the signal reported by DAMA/LIBRA, the DM-Ice17 data are consistent with no modulation in the energy range of 4-20 keV, providing the strongest limits on WIMP candidates from a direct detection experiment located in the Southern Hemisphere. Additionally, the successful deployment and stable operationmore » of 17 kg of NaI(Tl) crystal over 3.5 years establishes the South Pole ice as a viable location for future underground, low-background experiments.« less

Dysregulated fibroblast growth factor (FGF) signaling in neurological and psychiatric disorders.

PubMed

Turner, Cortney A; Eren-Koçak, Emine; Inui, Edny G; Watson, Stanley J; Akil, Huda

2016-05-01

The role of the fibroblast growth factor (FGF) system in brain-related disorders has received considerable attention in recent years. To understand the role of this system in neurological and psychiatric disorders, it is important to identify the specific members of the FGF family that are implicated, their location and the various mechanisms they can be modulated. Each disorder appears to impact specific molecular players in unique anatomical locations, and all of these could conceivably become targets for treatment. In the last several years, the issue of how to target this system directly has become an area of increasing interest. To date, the most promising therapeutics are small molecule inhibitors and antibodies that modulate FGF receptor (FGFR) function. Beyond attempting to modify the primary players affected by a given brain disorder, it may prove useful to target molecules, such as membrane-bound or extracellular proteins that interact with FGF ligands or FGFRs to modulate signaling. Published by Elsevier Ltd.

Monoaminergic modulation of photoreception in ascidian: evidence for a proto-hypothalamo-retinal territory

PubMed Central

2012-01-01

Background The retina of craniates/vertebrates has been proposed to derive from a photoreceptor prosencephalic territory in ancestral chordates, but the evolutionary origin of the different cell types making the retina is disputed. Except for photoreceptors, the existence of homologs of retinal cells remains uncertain outside vertebrates. Methods The expression of genes expressed in the sensory vesicle of the ascidian Ciona intestinalis including those encoding components of the monoaminergic neurotransmission systems, was analyzed by in situ hybridization or in vivo transfection of the corresponding regulatory elements driving fluorescent reporters. Modulation of photic responses by monoamines was studied by electrophysiology combined with pharmacological treatments. Results We show that many molecular characteristics of dopamine-synthesizing cells located in the vicinity of photoreceptors in the sensory vesicle of the ascidian Ciona intestinalis are similar to those of amacrine dopamine cells of the vertebrate retina. The ascidian dopamine cells share with vertebrate amacrine cells the expression of the key-transcription factor Ptf1a, as well as that of dopamine-synthesizing enzymes. Surprisingly, the ascidian dopamine cells accumulate serotonin via a functional serotonin transporter, as some amacrine cells also do. Moreover, dopamine cells located in the vicinity of the photoreceptors modulate the light-off induced swimming behavior of ascidian larvae by acting on alpha2-like receptors, instead of dopamine receptors, supporting a role in the modulation of the photic response. These cells are located in a territory of the ascidian sensory vesicle expressing genes found both in the retina and the hypothalamus of vertebrates (six3/6, Rx, meis, pax6, visual cycle proteins). Conclusion We propose that the dopamine cells of the ascidian larva derive from an ancestral multifunctional cell population located in the periventricular, photoreceptive field of the anterior neural tube of chordates, which also gives rise to both anterior hypothalamus and the retina in craniates/vertebrates. It also shows that the existence of multiple cell types associated with photic responses predates the formation of the vertebrate retina. PMID:22642675

Dark Energy Survey Year 1 Results: Galaxy Sample for BAO Measurement

DOE Office of Scientific and Technical Information (OSTI.GOV)

Crocce, M.; et al.

We define and characterise a sample of 1.3 million galaxies extracted from the first year of Dark Energy Survey data, optimised to measure Baryon Acoustic Oscillations in the presence of significant redshift uncertainties. The sample is dominated by luminous red galaxies located at redshiftsmore » $$z \\gtrsim 0.6$$. We define the exact selection using color and magnitude cuts that balance the need of high number densities and small photometric redshift uncertainties, using the corresponding forecasted BAO distance error as a figure-of-merit in the process. The typical photo-$z$ uncertainty varies from $$2.3\\%$$ to $$3.6\\%$$ (in units of 1+$z$) from $z=0.6$ to $1$, with number densities from $200$ to $130$ galaxies per deg$^2$ in tomographic bins of width $$\\Delta z = 0.1$$. Next we summarise the validation of the photometric redshift estimation. We characterise and mitigate observational systematics including stellar contamination, and show that the clustering on large scales is robust in front of those contaminants. We show that the clustering signal in the auto-correlations and cross-correlations is generally consistent with theoretical models, which serves as an additional test of the redshift distributions.« less

Lithostratigraphie, sédimentologie et évolution de deux bassins molassiques intramontagneux de la chaine Pan-Africaine: la Série pourprée de l'Ahnet, Nord-Ouest du Hoggar, Algérie

NASA Astrophysics Data System (ADS)

Ait-Kaci Ahmed, Ali; Moussine-Pouchkine, Alexis

The study of two of the intermontane molassic basins of the 'Série pourprée de l'Ahnet' shows that they developed independently both in time and space. The characteristics of their thick sedimentary infillings are quite different. The Ouallen basin is filled by essentially fine-grained sediments which were deposited in continental then marine or lacustrine environments; these sediments thicen from east to west. The In Semmen basin is characterised by coarser sediments which were deposited from south to north, in alluvial fan, fluvial, deltaic and slope environments. This basin is also characterised by an episode of carbonate sedimentation leading to the formation of a remarkable thin layer of carbonate, covering the entire sedimentary area, and perhaps related to a volcanic rhyolitic event. The history of the two basins is also marked by obvious tectonic events simultaneous with the sedimentation and related to the recurrent faulting of major Pan-African faults. These led to the formation of very coarse fanglomerates located near the fault scarps, and are probably responsible for the shape and the evolution of the basins.

Strategies for the profiling, characterisation and detailed structural analysis of N-linked oligosaccharides.

PubMed

Tharmalingam, Tharmala; Adamczyk, Barbara; Doherty, Margaret A; Royle, Louise; Rudd, Pauline M

2013-02-01

Many post-translational modifications, including glycosylation, are pivotal for the structural integrity, location and functional activity of glycoproteins. Sub-populations of proteins that are relocated or functionally changed by such modifications can change resting proteins into active ones, mediating specific effector functions, as in the case of monoclonal antibodies. To ensure safe and efficacious drugs it is essential to employ appropriate robust, quantitative analytical strategies that can (i) perform detailed glycan structural analysis, (ii) characterise specific subsets of glycans to assess known critical features of therapeutic activities (iii) rapidly profile glycan pools for at-line monitoring or high level batch to batch screening. Here we focus on these aspects of glycan analysis, showing how state-of-the-art technologies are required at all stages during the production of recombinant glycotherapeutics. These data can provide insights into processing pathways and suggest markers for intervention at critical control points in bioprocessing and also critical decision points in disease and drug monitoring in patients. Importantly, these tools are now enabling the first glycome/genome studies in large populations, allowing the integration of glycomics into other 'omics platforms in a systems biology context.

Infusing considerations of trophic dependencies into species distribution modelling.

PubMed

Trainor, Anne M; Schmitz, Oswald J

2014-12-01

Community ecology involves studying the interdependence of species with each other and their environment to predict their geographical distribution and abundance. Modern species distribution analyses characterise species-environment dependency well, but offer only crude approximations of species interdependency. Typically, the dependency between focal species and other species is characterised using other species' point occurrences as spatial covariates to constrain the focal species' predicted range. This implicitly assumes that the strength of interdependency is homogeneous across space, which is not generally supported by analyses of species interactions. This discrepancy has an important bearing on the accuracy of inferences about habitat suitability for species. We introduce a framework that integrates principles from consumer-resource analyses, resource selection theory and species distribution modelling to enhance quantitative prediction of species geographical distributions. We show how to apply the framework using a case study of lynx and snowshoe hare interactions with each other and their environment. The analysis shows how the framework offers a spatially refined understanding of species distribution that is sensitive to nuances in biophysical attributes of the environment that determine the location and strength of species interactions. © 2014 John Wiley & Sons Ltd/CNRS.

A scientific approach to the characterisation of the painting technique of an author: the case of Raffaele Rinaldi

NASA Astrophysics Data System (ADS)

La Russa, Mauro F.; Ruffolo, Silvestro A.; Belfiore, Cristina M.; Comite, Valeria; Casoli, Antonella; Berzioli, Michela; Nava, Gianluca

2014-03-01

During the last restoration of the six paintings by Raffaele Rinaldi (1851-1916), located in the church of Maria SS. Annunziata (Marano Principato, Cosenza, Italy), made between 1890 and 1903, several scientific investigations were carried out on them. The present work aims at classifying the painting in terms of its materials and technical particularities. The goal of this study was to characterise the painting technique of the painter, its evolution and possible additions made during previous restorations. Pigments, binder media and raw materials used for the application of the ground and the paint layers were studied using electronic microscopy equipped with energy dispersive spectroscopy qualitative microanalysis (SEM-EDS), infrared spectroscopy (FTIR) and gas chromatography coupled with mass spectrometry (GC/MS). Furthermore, a complete analysis of the state of preservation of these paintings represents a scientific aid and guide for its restoration, taking into account the severe damage not exclusively due to natural decay processes. Our data can provide information about historical and stylistic background as well as advise for correct planning of the cleaning procedures. The identification of materials allowed a correct restoration.

Chemical and mineralogical characterisation of weathered historical bricks from the Venice lagoonal environment

NASA Astrophysics Data System (ADS)

Schiavon, Nick; Mazzocchin, Gian Antonio; Baudo, Fulvio

2008-12-01

Surficial and bulk samples of historical bricks of different age (from XII to XVIII centuries) recovered from a campaign of archaeological excavations recently carried out at the site of a medieval monastery in the S. Giacomo in Paludo Island in theVenice Lagoon have been characterised by FT-IR, TGA-DTG and DTA, XRD, SEM + EDS. The samples belong to a particular brick type commonly used in the Venice region: the " altinella brick". The bulk relative abundance of primary (i.e. calcite and dolomite) and secondary firing minerals (i.e. diopside and wollastonite) in the bricks coupled with their relative geometrical dimensions allows placing the samples in a chronological sequence according to known historical changes in brickmaking firing temperatures and practices. Most of the bricks were used as paving material and have been exposed to the action of seawater salts (chlorides and sulphates) due to periodical submersion following high tide episodes. Salt-laden (gypsum, halite, mirabilite) surficial patinas are indeed present but salt weathering does not appear to have affected the overall structural soundness of the bricks in this now abandoned island as it is the case with brickwork located in other more populated (and polluted) areas in Venice and its lagoon.

Bone matrix to growth factors: location, location, location

PubMed Central

Todorovic, Vesna

2010-01-01

The demonstration that fibrillin-1 mutations perturb transforming growth factor (TGF)–β bioavailability/signaling in Marfan syndrome (MFS) changed the view of the extracellular matrix as a passive structural support to a dynamic modulator of cell behavior. In this issue, Nistala et al. (2010. J. Cell Biol. doi: 10.1083/jcb.201003089) advance this concept by demonstrating how fibrillin-1 and -2 regulate TGF-β and bone morphogenetic protein (BMP) action during osteoblast maturation. PMID:20855500

The neural correlates of competition during memory retrieval are modulated by attention to the cues.

PubMed

Danker, Jared F; Fincham, Jon M; Anderson, John R

2011-07-01

As people learn more facts about a concept, those facts become more difficult to remember. This is called the fan effect, where fan refers to the number of facts known about a concept. Increasing fan has been shown to decrease accuracy and increase response time and left ventrolateral prefrontal cortex (VLPFC) activity during retrieval. In this study, participants learned 36 arbitrary person-location pairings and made recognition decisions while we recorded brain activity using fMRI. We separately manipulated the fan of each person and location, as well as the training procedure with which each pair was studied. In the person focus condition, participants studied pairs with a picture of the person's face and used the person as a retrieval cue during training. In the location focus condition, participants studied pairs with a picture of the location and used the location as a retrieval cue during training. We found that the fan of the focused cue had a greater effect on response time, accuracy, and left VLPFC activity during retrieval than the fan of the unfocused cue. We also found that the parahippocampal place area (PPA) was more active during the recognition of pairs studied in the location focus condition, but not when the fan of the location was high. Overall, we found opposite effects of fan on VLPFC and PPA that were modulated by cue focus. Copyright © 2011 Elsevier Ltd. All rights reserved.

Spatial Probability Dynamically Modulates Visual Target Detection in Chickens

PubMed Central

Sridharan, Devarajan; Ramamurthy, Deepa L.; Knudsen, Eric I.

2013-01-01

The natural world contains a rich and ever-changing landscape of sensory information. To survive, an organism must be able to flexibly and rapidly locate the most relevant sources of information at any time. Humans and non-human primates exploit regularities in the spatial distribution of relevant stimuli (targets) to improve detection at locations of high target probability. Is the ability to flexibly modify behavior based on visual experience unique to primates? Chickens (Gallus domesticus) were trained on a multiple alternative Go/NoGo task to detect a small, briefly-flashed dot (target) in each of the quadrants of the visual field. When targets were presented with equal probability (25%) in each quadrant, chickens exhibited a distinct advantage for detecting targets at lower, relative to upper, hemifield locations. Increasing the probability of presentation in the upper hemifield locations (to 80%) dramatically improved detection performance at these locations to be on par with lower hemifield performance. Finally, detection performance in the upper hemifield changed on a rapid timescale, improving with successive target detections, and declining with successive detections at the diagonally opposite location in the lower hemifield. These data indicate the action of a process that in chickens, as in primates, flexibly and dynamically modulates detection performance based on the spatial probabilities of sensory stimuli as well as on recent performance history. PMID:23734188

Exploring the potential of 3D Zernike descriptors and SVM for protein-protein interface prediction.

PubMed

Daberdaku, Sebastian; Ferrari, Carlo

2018-02-06

The correct determination of protein-protein interaction interfaces is important for understanding disease mechanisms and for rational drug design. To date, several computational methods for the prediction of protein interfaces have been developed, but the interface prediction problem is still not fully understood. Experimental evidence suggests that the location of binding sites is imprinted in the protein structure, but there are major differences among the interfaces of the various protein types: the characterising properties can vary a lot depending on the interaction type and function. The selection of an optimal set of features characterising the protein interface and the development of an effective method to represent and capture the complex protein recognition patterns are of paramount importance for this task. In this work we investigate the potential of a novel local surface descriptor based on 3D Zernike moments for the interface prediction task. Descriptors invariant to roto-translations are extracted from circular patches of the protein surface enriched with physico-chemical properties from the HQI8 amino acid index set, and are used as samples for a binary classification problem. Support Vector Machines are used as a classifier to distinguish interface local surface patches from non-interface ones. The proposed method was validated on 16 classes of proteins extracted from the Protein-Protein Docking Benchmark 5.0 and compared to other state-of-the-art protein interface predictors (SPPIDER, PrISE and NPS-HomPPI). The 3D Zernike descriptors are able to capture the similarity among patterns of physico-chemical and biochemical properties mapped on the protein surface arising from the various spatial arrangements of the underlying residues, and their usage can be easily extended to other sets of amino acid properties. The results suggest that the choice of a proper set of features characterising the protein interface is crucial for the interface prediction task, and that optimality strongly depends on the class of proteins whose interface we want to characterise. We postulate that different protein classes should be treated separately and that it is necessary to identify an optimal set of features for each protein class.

Implementation of a chemical background method (OH-CHEM) for measurements of OH using the Leeds FAGE instrument: Characterisation and observations from a coastal location

NASA Astrophysics Data System (ADS)

Woodward-Massey, R.; Cryer, D. R.; Whalley, L. K.; Ingham, T.; Seakins, P. W.; Heard, D. E.; Stimpson, L. M.

2015-12-01

The removal of pollutants and greenhouse gases in the troposphere is dominated by reactions with the hydroxyl radical (OH), which is closely coupled to the hydroperoxy radical (HO2). Comparisons of the levels of OH and HO2 observed during field campaigns to the results of detailed chemical box models serve as a vital tool to assess our understanding of the underlying chemical mechanisms involved in tropospheric oxidation. Recent measurements of OH and HO2 radicals are significantly higher than those predicted by models for some instruments measuring in certain environments, especially those influenced by high emissions of biogenic compounds such as isoprene, prompting intense laboratory research to account for such discrepancies. While current chemical mechanisms are likely incomplete, it is also possible that, at least in part, these elevated radical observations have been influenced by instrumental biases from interfering species. Recent studies have suggested that fluorescence assay by gas expansion (FAGE) instruments may be susceptible to an unknown interference in the measurement of OH. This hypothesis can be tested through the implementation of an alternative method to determine the OH background signal, whereby OH is removed by the addition of a chemical scavenger prior to sampling by FAGE. The Leeds FAGE instrument was modified to facilitate this method by the construction of an inlet pre-injector (IPI), where OH is removed through reaction with propane. The modified Leeds FAGE instrument was deployed at a coastal location in southeast England during summer 2015 as part of the ICOZA (Integrated Chemistry of OZone in the Atmosphere) project. Measurements of OH made using both background methods will be presented, alongside results from laboratory characterisation experiments and details of the IPI design.

Marine turtles are not fussy nesters: a novel test of small-scale nest site selection using structure from motion beach terrain information

PubMed Central

Leon, Javier X.; Gilby, Ben L.; Olds, Andrew D.; Schlacher, Thomas A.

2017-01-01

Background Nest selection is widely regarded as a key process determining the fitness of individuals and viability of animal populations. For marine turtles that nest on beaches, this is particularly pivotal as the nesting environment can significantly control reproductive success.The aim of this study was to identify the environmental attributes of beaches (i.e., morphology, vegetation, urbanisation) that may be associated with successful oviposition in green and loggerhead turtle nests. Methods We quantified the proximity of turtle nests (and surrounding beach locations) to urban areas, measured their exposure to artificial light, and used ultra-high resolution (cm-scale) digital surface models derived from Structure-from-Motion (SfM) algorithms, to characterise geomorphic and vegetation features of beaches on the Sunshine Coast, eastern Australia. Results At small spatial scales (i.e., <100 m), we found no evidence that turtles selected nest sites based on a particular suite of environmental attributes (i.e., the attributes of nest sites were not consistently different from those of surrounding beach locations). Nest sites were, however, typically characterised by occurring close to vegetation, on parts of the shore where the beach- and dune-face was concave and not highly rugged, and in areas with moderate exposure to artificial light. Conclusion This study used a novel empirical approach to identify the attributes of turtle nest sites from a broader ‘envelope’ of environmental nest traits, and is the first step towards optimizing conservation actions to mitigate, at the local scale, present and emerging human impacts on turtle nesting beaches. PMID:28070454

Intra-urban and street scale variability of BTEX, NO 2 and O 3 in Birmingham, UK: Implications for exposure assessment

NASA Astrophysics Data System (ADS)

Vardoulakis, Sotiris; Solazzo, Efisio; Lumbreras, Julio

2011-09-01

Automatic monitoring networks have the ability of capturing air pollution episodes, as well as short- and long-term air quality trends in urban areas that can be used in epidemiological studies. However, due to practical constraints (e.g. cost and bulk of equipment), the use of automatic analysers is restricted to a limited number of roadside and background locations within a city. As a result, certain localised air pollution hotspots may be overlooked or overemphasised, especially near heavily trafficked street canyons and intersections. This has implications for compliance with regulatory standards and may cause exposure misclassification in epidemiological studies. Apart from automatic analysers, low cost passive diffusion tubes can be used to characterise the spatial variability of air pollution in urban areas. In this study, BTEX, NO 2 and O 3 data from a one-year passive sampling survey were used to characterise the intra-urban and street scale spatial variability of traffic-related pollutants in Birmingham (UK). In addition, continuous monitoring of NO 2, NO x, O 3, CO, SO 2, PM 10 and PM 2.5 from three permanent monitoring sites was used to identify seasonal and annual pollution patterns. The passive sampling measurements allowed us to evaluate the representativeness of a permanent roadside monitoring site that has recorded some of the highest NO 2 and PM 10 concentrations in Birmingham in recent years. Dispersion modelling was also used to gain further insight into pollutant sources and dispersion characteristics at this location. The strong spatial concentration gradients observed in busy streets, as well as the differences between roadside and urban background levels highlight the importance of appropriate positioning of air quality monitoring equipment in cities.

A pericentric inversion of chromosome X disrupting F8 and resulting in haemophilia A.

PubMed

Xin, Yu; Zhou, Jingyi; Ding, Qiulan; Chen, Changming; Wu, Xi; Wang, Xuefeng; Wang, Hongli; Jiang, Xiaofeng

2017-08-01

The frequency of X chromosome pericentric inversion is much less than that of autosome chromosome. We hereby characterise a pericentric inversion of X chromosome associated with severe factor VIII (FVIII) deficiency in a sporadic haemophilia A (HA) pedigree. PCR primer walking and genome walking strategies were adopted to identify the exact breakpoints of the inversion. Copy number variations (CNVs) of the F8 and the whole chromosomes were detected by AccuCopy and Affymetrix CytoScan High Definition (HD) assays, respectively. A karyotype analysis was performed by cytogenetic G banding technique. We identified a previously undescribed type of pericentric inversion of the X chromosome [inv(X)(p11.21q28)] in the proband with FVIII:C <1%. One breakpoint was located in the intron 7 of the F 8, which disrupted the transcription of the F8, and the other located in the upstream of the PFKFB1 of the X chromosome. The inversion segment was approximately 64.4% of the total chromosomal length. The karyotype analysis of the X chromosome confirmed the pericentric inversion of the X chromosome in the proband and his mother. A haplotype analysis traced the inversion to his maternal grandfather, who was not a somatic mosaic of the inversion. This finding indicated that the causative mutation may originate from his germ cells or a rare possibility of germ-cell mosaicism. The characterisation of pericentric inversion involving F8 extended the molecular mechanisms causing HA. The pericentric inversion rearrangement involves F8 by non-homologous end joining is responsible for pathogensis of severe HA. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

Spatial variation of volcanic rock geochemistry in the Virunga Volcanic Province: Statistical analysis of an integrated database

NASA Astrophysics Data System (ADS)

Barette, Florian; Poppe, Sam; Smets, Benoît; Benbakkar, Mhammed; Kervyn, Matthieu

2017-10-01

We present an integrated, spatially-explicit database of existing geochemical major-element analyses available from (post-) colonial scientific reports, PhD Theses and international publications for the Virunga Volcanic Province, located in the western branch of the East African Rift System. This volcanic province is characterised by alkaline volcanism, including silica-undersaturated, alkaline and potassic lavas. The database contains a total of 908 geochemical analyses of eruptive rocks for the entire volcanic province with a localisation for most samples. A preliminary analysis of the overall consistency of the database, using statistical techniques on sets of geochemical analyses with contrasted analytical methods or dates, demonstrates that the database is consistent. We applied a principal component analysis and cluster analysis on whole-rock major element compositions included in the database to study the spatial variation of the chemical composition of eruptive products in the Virunga Volcanic Province. These statistical analyses identify spatially distributed clusters of eruptive products. The known geochemical contrasts are highlighted by the spatial analysis, such as the unique geochemical signature of Nyiragongo lavas compared to other Virunga lavas, the geochemical heterogeneity of the Bulengo area, and the trachyte flows of Karisimbi volcano. Most importantly, we identified separate clusters of eruptive products which originate from primitive magmatic sources. These lavas of primitive composition are preferentially located along NE-SW inherited rift structures, often at distance from the central Virunga volcanoes. Our results illustrate the relevance of a spatial analysis on integrated geochemical data for a volcanic province, as a complement to classical petrological investigations. This approach indeed helps to characterise geochemical variations within a complex of magmatic systems and to identify specific petrologic and geochemical investigations that should be tackled within a study area.

Isolation, cloning and structural characterisation of boophilin, a multifunctional Kunitz-type proteinase inhibitor from the cattle tick.

PubMed

Macedo-Ribeiro, Sandra; Almeida, Carla; Calisto, Bárbara M; Friedrich, Thomas; Mentele, Reinhard; Stürzebecher, Jörg; Fuentes-Prior, Pablo; Pereira, Pedro José Barbosa

2008-02-20

Inhibitors of coagulation factors from blood-feeding animals display a wide variety of structural motifs and inhibition mechanisms. We have isolated a novel inhibitor from the cattle tick Boophilus microplus, one of the most widespread parasites of farm animals. The inhibitor, which we have termed boophilin, has been cloned and overexpressed in Escherichia coli. Mature boophilin is composed of two canonical Kunitz-type domains, and inhibits not only the major procoagulant enzyme, thrombin, but in addition, and by contrast to all other previously characterised natural thrombin inhibitors, significantly interferes with the proteolytic activity of other serine proteinases such as trypsin and plasmin. The crystal structure of the bovine alpha-thrombin.boophilin complex, refined at 2.35 A resolution reveals a non-canonical binding mode to the proteinase. The N-terminal region of the mature inhibitor, Q16-R17-N18, binds in a parallel manner across the active site of the proteinase, with the guanidinium group of R17 anchored in the S(1) pocket, while the C-terminal Kunitz domain is negatively charged and docks into the basic exosite I of thrombin. This binding mode resembles the previously characterised thrombin inhibitor, ornithodorin which, unlike boophilin, is composed of two distorted Kunitz modules. Unexpectedly, both boophilin domains adopt markedly different orientations when compared to those of ornithodorin, in its complex with thrombin. The N-terminal boophilin domain rotates 9 degrees and is displaced by 6 A, while the C-terminal domain rotates almost 6 degrees accompanied by a 3 A displacement. The reactive-site loop of the N-terminal Kunitz domain of boophilin with its P(1) residue, K31, is fully solvent exposed and could thus bind a second trypsin-like proteinase without sterical restraints. This finding explains the formation of a ternary thrombin.boophilin.trypsin complex, and suggests a mechanism for prothrombinase inhibition in vivo.

Development of solid-state NMR techniques for the characterisation of pharmaceutical compounds

NASA Astrophysics Data System (ADS)

Tatton, Andrew S.

Structural characterisation in the solid state is an important step in understanding the physical and chemical properties of a material. Solid-state NMR techniques applied to solid delivery forms are presented as an alternative to more established structural characterisation methods. The effect of homonuclear decoupling upon heteronuclear couplings is investigated using a combination of experimental and density-matrix simulation results acquired from a 13C-1H spinecho pulse sequence, modulated by scalar couplings. It is found that third-order cross terms under MAS and homonuclear decoupling contribute to strong dephasing effects in the NMR signal. Density-matrix simulations allow access to parameters currently unattainable in experiment, and demonstrate that higher homonuclear decoupling rf nutation frequencies reduce the magnitude of third-order cross terms. 15N-1H spinecho experiments were applied to pharmaceutically relevant samples to differentiate between the number of directly attached protons. Using this method, proton transfer in an acid-base reaction is proven in pharmaceutical salts. The indirect detection of 14N lineshapes via protons obtained using 2D 14N-1H HMQC experiments is presented, where coherence transfer is achieved via heteronuclear through-space dipolar couplings. The importance of fast MAS frequencies is demonstrated, and it is found that increasing the recoupling duration reveals longer range NH proximities. The 2D 14N-1H HMQC method is used to demonstrate the presence of specific hydrogen bonding interactions, and thus aid in identifying molecular association in a cocrystal and an amorphous dispersion. In addition, hydrogen bonding motifs were identified by observing the changes in the 14N quadrupolar parameters between individual molecular components relative to the respective solid delivery form. First-principles calculations of NMR chemical shifts and quadrupolar parameters using the GIPAW method were combined with 14N-1H experimental results to assist with spectral assignment and the identification of the hydrogen bonding interactions.

The felt presence of other minds: Predictive processing, counterfactual predictions, and mentalising in autism.

PubMed

Palmer, Colin J; Seth, Anil K; Hohwy, Jakob

2015-11-01

The mental states of other people are components of the external world that modulate the activity of our sensory epithelia. Recent probabilistic frameworks that cast perception as unconscious inference on the external causes of sensory input can thus be expanded to enfold the brain's representation of others' mental states. This paper examines this subject in the context of the debate concerning the extent to which we have perceptual awareness of other minds. In particular, we suggest that the notion of perceptual presence helps to refine this debate: are others' mental states experienced as veridical qualities of the perceptual world around us? This experiential aspect of social cognition may be central to conditions such as autism spectrum disorder, where representations of others' mental states seem to be selectively compromised. Importantly, recent work ties perceptual presence to the counterfactual predictions of hierarchical generative models that are suggested to perform unconscious inference in the brain. This enables a characterisation of mental state representations in terms of their associated counterfactual predictions, allowing a distinction between spontaneous and explicit forms of mentalising within the framework of predictive processing. This leads to a hypothesis that social cognition in autism spectrum disorder is characterised by a diminished set of counterfactual predictions and the reduced perceptual presence of others' mental states. Copyright © 2015 Elsevier Inc. All rights reserved.

The role of plant mycorrhizal type and status in modulating the relationship between plant and arbuscular mycorrhizal fungal communities.

PubMed

Neuenkamp, Lena; Moora, Mari; Öpik, Maarja; Davison, John; Gerz, Maret; Männistö, Minna; Jairus, Teele; Vasar, Martti; Zobel, Martin

2018-01-25

Interactions between communities of plants and arbuscular mycorrhizal (AM) fungi shape fundamental ecosystem properties. Experimental evidence suggests that compositional changes in plant and AM fungal communities should be correlated, but empirical data from natural ecosystems are scarce. We investigated the dynamics of covariation between plant and AM fungal communities during three stages of grassland succession, and the biotic and abiotic factors shaping these dynamics. Plant communities were characterised using vegetation surveys. AM fungal communities were characterised by 454-sequencing of the small subunit rRNA gene and identification against the AM fungal reference database MaarjAM. AM fungal abundance was estimated using neutral-lipid fatty acids (NLFAs). Multivariate correlation analysis (Procrustes) revealed a significant relationship between plant and AM fungal community composition. The strength of plant-AM fungal correlation weakened during succession following cessation of grassland management, reflecting changes in the proportion of plants exhibiting different AM status. Plant-AM fungal correlation was strong when the abundance of obligate AM plants was high, and declined as the proportion of facultative AM plants increased. We conclude that the extent to which plants rely on AM symbiosis can determine how tightly communities of plants and AM fungi are interlinked, regulating community assembly of both symbiotic partners. © 2018 The Authors. New Phytologist © 2018 New Phytologist Trust.

Optimal spectral tracking--adapting to dynamic regime change.

PubMed

Brittain, John-Stuart; Halliday, David M

2011-01-30

Real world data do not always obey the statistical restraints imposed upon them by sophisticated analysis techniques. In spectral analysis for instance, an ergodic process--the interchangeability of temporal for spatial averaging--is assumed for a repeat-trial design. Many evolutionary scenarios, such as learning and motor consolidation, do not conform to such linear behaviour and should be approached from a more flexible perspective. To this end we previously introduced the method of optimal spectral tracking (OST) in the study of trial-varying parameters. In this extension to our work we modify the OST routines to provide an adaptive implementation capable of reacting to dynamic transitions in the underlying system state. In so doing, we generalise our approach to characterise both slow-varying and rapid fluctuations in time-series, simultaneously providing a metric of system stability. The approach is first applied to a surrogate dataset and compared to both our original non-adaptive solution and spectrogram approaches. The adaptive OST is seen to display fast convergence and desirable statistical properties. All three approaches are then applied to a neurophysiological recording obtained during a study on anaesthetic monitoring. Local field potentials acquired from the posterior hypothalamic region of a deep brain stimulation patient undergoing anaesthesia were analysed. The characterisation of features such as response delay, time-to-peak and modulation brevity are considered. Copyright © 2010 Elsevier B.V. All rights reserved.

The nuclear factor (erythroid-derived 2)-like 2 (NRF2) antioxidant response promotes melanocyte viability and reduces toxicity of the vitiligo-inducing phenol monobenzone.

PubMed

Arowojolu, Omotayo A; Orlow, Seth J; Elbuluk, Nada; Manga, Prashiela

2017-07-01

Vitiligo, characterised by progressive melanocyte death, can be initiated by exposure to vitiligo-inducing phenols (VIPs). VIPs generate oxidative stress in melanocytes and activate the master antioxidant regulator NRF2. While NRF2-regulated antioxidants are reported to protect melanocytes from oxidative stress, the role of NRF2 in the melanocyte response to monobenzone, a clinically relevant VIP, has not been characterised. We hypothesised that activation of NRF2 may protect melanocytes from monobenzone-induced toxicity. We observed that knockdown of NRF2 or NRF2-regulated antioxidants NQO1 and PRDX6 reduced melanocyte viability, but not viability of keratinocytes and fibroblasts, suggesting that melanocytes were preferentially dependent upon NRF2 activity for growth compared to other cutaneous cells. Furthermore, melanocytes activated the NRF2 response following monobenzone exposure and constitutive NRF2 activation reduced monobenzone toxicity, supporting NRF2's role in the melanocyte stress response. In contrast, melanocytes from individuals with vitiligo (vitiligo melanocytes) did not activate the NRF2 response as efficiently. Dimethyl fumarate-mediated NRF2 activation protected normal and vitiligo melanocytes against monobenzone-induced toxicity. Given the contribution of oxidant-antioxidant imbalance in vitiligo, modulation of this pathway may be of therapeutic interest. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Both a Nicotinic Single Nucleotide Polymorphism (SNP) and a Noradrenergic SNP Modulate Working Memory Performance when Attention Is Manipulated

ERIC Educational Resources Information Center

Greenwood, Pamela M.; Sundararajan, Ramya; Lin, Ming-Kuan; Kumar, Reshma; Fryxell, Karl J.; Parasuraman, Raja

2009-01-01

We investigated the relation between the two systems of visuospatial attention and working memory by examining the effect of normal variation in cholinergic and noradrenergic genes on working memory performance under attentional manipulation. We previously reported that working memory for location was impaired following large location precues,…

Parasitic nematode Meloidogyne incognita interactions with different Capsicum annum cultivars reveal the chemical constituents modulating root herbiovry

USDA-ARS?s Scientific Manuscript database

Plant volatile signatures are often used as cues by herbivores to locate their preferred hosts. Here, we report on the volatile organic compounds used by the subterranean root-knot nematode (RKN) Meloidogyne incognita for host location. We compared responses of infective second stage juveniles (J2s)...

Locating the Business. PACE Revised. Level 3. Unit 7. Research & Development Series No. 240CB7.

ERIC Educational Resources Information Center

Ashmore, M. Catherine; Pritz, Sandra G.

This individualized, competency-based unit on locating businesses, the seventh of 18 modules, is on the third level of the revised Program for Acquiring Competence in Entrepreneurship (PACE). Intended for the advanced secondary and postsecondary levels and for adults wanting training or retraining, this unit, together with the other materials at…

Orion Crew Module Move

NASA Image and Video Library

2017-11-17

Technicians in clean-room suits attach a crane to the Orion crew module for Exploration Mission-1 for its move to the thermal chamber in the Neil Armstrong Operations and Checkout Building high bay at NASA's Kennedy Space Center in Florida. Orion will be lifted out of a test stand and lowered onto another stand to for the move. The crew module will undergo a thermal cycle test to assess the workmanship of critical hardware and structural locations. The test also demonstrates crew module subsystem operations in a thermally stressing environment to confirm no damage or anomalous hardware conditions as a result of the test. The Orion spacecraft will launch atop NASA's Space Launch System rocket on its first uncrewed integrated flight.

Atomic force microscopy captures length phenotypes in single proteins

PubMed Central

Carrion-Vazquez, Mariano; Marszalek, Piotr E.; Oberhauser, Andres F.; Fernandez, Julio M.

1999-01-01

We use single-protein atomic force microscopy techniques to detect length phenotypes in an Ig module. To gain amino acid resolution, we amplify the mechanical features of a single module by engineering polyproteins composed of up to 12 identical repeats. We show that on mechanical unfolding, mutant polyproteins containing five extra glycine residues added to the folded core of the module extend 20 Å per module farther than the wild-type polyproteins. By contrast, similar insertions near the N or C termini have no effect. Hence, our atomic force microscopy measurements readily discriminate the location of the insert and measure its size with a resolution similar to that of NMR and x-ray crystallography. PMID:10500169

Interrogation, and detection system

DOEpatents

Baldwin, Howard A.; Depp, Steven W.; Koelle, Alfred R.; Freyman, Robert W.

1978-02-21

The specification relates to a telemetering apparatus comprising a generator which generates at least a single frequency rf signal, a transponder for receiving that signal and for amplitude modulating it in accordance with information selected for transmission, an antenna on the transponder for reflecting the amplitude modulated signal, and a receiver which is preferably located at the generator. The receiver processes the signal to determine the information carried thereby.

DCERP Annual Technical Report III: March 2009-February 2010. Executive Summary

DTIC Science & Technology

2010-04-01

groundwater passing though marshes to the estuary. Loading estimates may vary considerably depending on inter-annual hydrologic (storm versus drought ...climatic events (i.e., hurricanes and droughts ); and integrate results with the other DCERP modules. The benefits of the Aquatic/Estuarine Module...inter-annual hydrologic (storm versus drought years) variability. ▪ Several large phytoplankton blooms in mid-estuary to upper estuary locations

TransHab Materials Selection

NASA Technical Reports Server (NTRS)

Pedley, M. D.; Mayeaux, B.

2001-01-01

A viewgraph presentation gives an overview of the materials selection for the TransHab, the habitation module on the International Space Station (ISS). Details are given on the location of TransHab on the ISS, the multilayer inflatable shell that surrounds the module, the materials requirements (including information on the expected thermal environment), the materials selection challenges, the bladder materials requirements and testing, and meteoroid/debris shielding material.

ULF Generation by Modulated Ionospheric Heating

NASA Astrophysics Data System (ADS)

Chang, C.; Labenski, J.; Wallace, T.; Papadopoulos, K.

2013-12-01

Modulated ionospheric heating experiments designed to generate ULF waves using the HAARP heater have been conducted since 2007. Artificial ULF waves in the Pc1 frequency range were observed from space and by ground induction magnetometers located in the vicinity of the heater as well as at long distances. Two distinct generation mechanisms of artificial ULF waves were identified. The first was electroject modulation under geomagnetically disturbed conditions. The second was pressure modulation in the E and F regions of the ionosphere under quiet conditions. Ground detections of ULF waves near the heater included both Shear Alfven waves and Magnetosonic waves generated by electrojet and/or pressure modulations. Distant ULF detections involved Magnetosonic wave propagation in the Alfvenic duct with pressure modulation as the most likely source. Summary of our observations and theoretical interpretations will be presented at the meeting. We would like to acknowledge the support provided by the staff at the HAARP facility during our ULF experiments.

Molecular characterisation and interpretation of genetic diversity within globally distributed germplasm collections of tall fescue (Festuca arundinacea Schreb.) and meadow fescue (F. pratensis Huds.).

PubMed

Hand, Melanie L; Cogan, Noel O I; Forster, John W

2012-04-01

Allohexaploid tall fescue (Festuca arundinacea Schreb. syn. Lolium arundinaceum [Schreb.] Darbysh.) is an agriculturally important grass cultivated for pasture and turf world-wide. Genetic improvement of tall fescue could benefit from the use of non-domesticated germplasm to diversify breeding populations through the incorporation of novel and superior allele content. However, such potential germplasm must first be characterised, as three major morphotypes (Continental, Mediterranean and rhizomatous) with varying degrees of hybrid interfertility are commonly described within this species. As hexaploid tall fescue is also a member of a polyploid species complex that contains tetraploid, octoploid and decaploid taxa, it is also possible that germplasm collections may have inadvertently sampled some of these sub-species. In this study, 1,040 accessions from the publicly available United States Department of Agriculture tall fescue and meadow fescue germplasm collections were investigated. Sequence of the chloroplast genome-located matK gene and the nuclear ribosomal DNA internal transcribed spacer (rDNA ITS) permitted attribution of accessions to the three previously known morphotypes and also revealed the presence of tall fescue sub-species of varying ploidy levels, as well as other closely related species. The majority of accessions were, however, identified as Continental hexaploid tall fescue. Analysis using 34 simple sequence repeat markers was able to further investigate the level of genetic diversity within each hexaploid tall fescue morphotype group. At least two genetically distinct sub-groups of Continental hexaploid tall fescue were identified which are probably associated with palaeogeographic range expansion of this morphotype. This work has comprehensively characterised a large and complex germplasm collection and has identified genetically diverse accessions which may potentially contribute valuable alleles at agronomic loci for tall fescue cultivar improvement programs.

Using high-frequency sensors to identify hydroclimatological controls on storm-event variability in catchment nutrient fluxes and source zone activation

NASA Astrophysics Data System (ADS)

Blaen, Phillip; Khamis, Kieran; Lloyd, Charlotte; Krause, Stefan

2017-04-01

At the river catchment scale, storm events can drive highly variable behaviour in nutrient and water fluxes, yet short-term dynamics are frequently missed by low resolution sampling regimes. In addition, nutrient source contributions can vary significantly within and between storm events. Our inability to identify and characterise time dynamic source zone contributions severely hampers the adequate design of land use management practices in order to control nutrient exports from agricultural landscapes. Here, we utilise an 8-month high-frequency (hourly) time series of streamflow, nitrate concentration (NO3) and fluorescent dissolved organic matter concentration (FDOM) derived from optical in-situ sensors located in a headwater agricultural catchment. We characterised variability in flow and nutrient dynamics across 29 storm events. Storm events represented 31% of the time series and contributed disproportionately to nutrient loads (43% of NO3 and 36% of CDOM) relative to their duration. Principal components analysis of potential hydroclimatological controls on nutrient fluxes demonstrated that a small number of components, representing >90% of variance in the dataset, were highly significant model predictors of inter-event variability in catchment nutrient export. Hysteresis analysis of nutrient concentration-discharge relationships suggested spatially discrete source zones existed for NO3 and FDOM, and that activation of these zones varied on an event-specific basis. Our results highlight the benefits of high-frequency in-situ monitoring for characterising complex short-term nutrient dynamics and unravelling connections between hydroclimatological variability and river nutrient export and source zone activation under extreme flow conditions. These new process-based insights are fundamental to underpinning the development of targeted management measures to reduce nutrient loading of surface waters.