Task-Dependent Behavioral Dynamics Make the Case for Temporal Integration in Multiple Strategies during Odor Processing

PubMed Central

Brown, Austin; Mehta, Nisarg; Vujovic, Mark; Amina, Tasneem; Fixsen, Bethany

2017-01-01

Differing results in olfactory-based decision-making research regarding the amount of time that rats and mice use to identify odors have led to some disagreements about odor-processing mechanics, including whether or not rodents use temporal integration (i.e., sniffing longer to identify odors better). Reported differences in behavioral strategies may be due to the different types of tasks used in different laboratories. Some researchers have reported that animals performing two-alternative choice (TAC) tasks need only 1–2 sniffs and do not increase performance with longer sampling. Others have reported that animals performing go/no-go (GNG) tasks increase sampling times and performance for difficult discriminations, arguing for temporal integration. We present results from four experiments comparing GNG and TAC tasks over several behavioral variables (e.g., performance, sampling duration). When rats know only one task, they perform better in GNG than in TAC. However, performance was not statistically different when rats learned and were tested in both tasks. Rats sample odors longer in GNG than in TAC, even when they know both tasks and perform them in the same or different sessions. Longer sampling is associated with better performance for both tasks in difficult discriminations, which supports the case for temporal integration over ≥2–6 sniffs in both tasks. These results illustrate that generalizations from a single task about behavioral or cognitive abilities (e.g., processing, perception) do not capture the full range of complexity and can significantly impact inferences about general abilities in sensory perception. SIGNIFICANCE STATEMENT Behavioral tasks and training and testing history affect measured outcomes in cognitive tests. Rats sample odors longer in a go/no-go (GNG) than in a two-alternative choice (TAC) task, performing better in GNG unless they know both tasks. Odor-sampling time is extended in both tasks when the odors to be discriminated are very similar. Rats may extend sampling time to integrate odor information up to ∼0.5 s (2–6 sniffs). Such factors as task, task parameters, and training history affect decision times and performance, making it important to use multiple tasks when making inferences about sensory or cognitive processing. PMID:28336570

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wu, Ping; Deng, Yuqun; Science and Technology on High Power Microwave Laboratory, Northwest Institute of Nuclear Technology, Xi'an 710024

In relativistic backward wave oscillators (RBWOs), although the slow wave structure (SWS) and electron beam determine the main characteristics of beam-wave interaction, many other factors can also significantly affect the microwave generation process. This paper investigates the influence of voltage rise time on beam-wave interaction in RBWOs. Preliminary analysis and PIC simulations demonstrate if the voltage rise time is moderately long, the microwave frequency will gradually increase during the startup process until the voltage reaches its amplitude, which can be explained by the dispersion relation. However, if the voltage rise time is long enough, the longitudinal resonance of the finitely-longmore » SWS will force the RBWO to work with unwanted longitudinal modes for a while and then gradually hop to the wanted longitudinal mode, and this will lead to an impure microwave frequency spectrum. Besides, a longer voltage rise time will delay the startup process and thus lead to a longer microwave saturation time. And if unwanted longitudinal modes are excited due to long voltage rise time, the microwave saturation time will be further lengthened. Therefore, the voltage rise time of accelerators adopted in high power microwave technology should not be too long in case unwanted longitudinal modes are excited.« less

Unconscious and conscious processing of negative emotions examined through affective priming.

PubMed

Okubo, Chisa; Ogawa, Toshiki

2013-04-01

This study investigated unconscious and conscious processes by which negative emotions arise. Participants (26 men, 47 women; M age = 20.3 yr.) evaluated target words that were primed with subliminally or supraliminally presented emotional pictures. Stimulus onset asynchrony was either 200 or 800 msec. With subliminal presentations, reaction times to negative targets were longer than reaction times to positive targets after negative primes for the 200-msec. stimulus onset asynchrony. Reaction times to positive targets after negative or positive primes were shorter when the stimulus onset asynchrony was 800 msec. For supraliminal presentations, reaction times were longer when evaluating targets that followed emotionally opposite primes. When emotional stimuli were consciously distinguished, the evoked emotional states might lead to emotional conflicts, although the qualitatively different effects might be caused when subliminally presented emotion evoking stimulus was appraised unconsciously; that possibility was discussed.

Neural cascade of conflict processing: Not just time-on-task.

PubMed

McKay, Cameron C; van den Berg, Berry; Woldorff, Marty G

2017-02-01

In visual conflict tasks (e.g., Stroop or flanker), response times (RTs) are generally longer on incongruent trials relative to congruent ones. Two event-related-potential (ERP) components classically associated with the processing of stimulus conflict are the fronto-central, incongruency-related negativity (N inc ) and the posterior late-positive complex (LPC), which are derived from the ERP difference waves for incongruent minus congruent trials. It has been questioned, however, whether these effects, or other neural measures of incongruency (e.g., fMRI responses in the anterior cingulate), reflect true conflict processing, or whether such effects derive mainly from differential time-on-task. To address this question, we leveraged high-temporal-resolution ERP measures of brain activity during two behavioral tasks. The first task, a modified Erikson flanker paradigm (with congruent and incongruent trials), was used to evoke the classic RT and ERP effects associated with conflict. The second was a non-conflict control task in which, participants visually discriminated a single stimulus (with easy and hard discrimination conditions). Behaviorally, the parameters were titrated to yield similar RT effects of conflict and difficulty (27ms). Neurally, both within-task contrasts showed an initial fronto-central negative-polarity wave (N2-latency effect), but they then diverged. In the difficulty difference wave, the initial negativity led directly into the posterior LPC, whereas in the incongruency contrast the initial negativity was followed a by a second fronto-central negative peak (N inc ), which was then followed by a considerably longer-latency LPC. These results provide clear evidence that the longer processing for incongruent stimulus inputs do not just reflect time-on-task or difficulty, but include a true conflict-processing component. Copyright © 2017 Elsevier Ltd. All rights reserved.

Neural cascade of conflict processing: not just time-on-task

PubMed Central

McKay, Cameron C.; van den Berg, Berry; Woldorff, Marty G.

2017-01-01

In visual conflict tasks (e.g., Stroop or flanker), response times (RTs) are generally longer on incongruent trials relative to congruent ones. Two event-related-potential (ERP) components classically associated with the processing of stimulus conflict are the fronto-central, incongruency-related negativity (Ninc) and the posterior late-positive complex (LPC), which are derived from the ERP difference waves for incongruent minus congruent trials. It has been questioned, however, whether these effects, or other neural measures of incongruency (e.g., fMRI responses in the anterior cingulate), reflect true conflict processing, or whether such effects derive mainly from differential time-on-task. To address this question, we leveraged high-temporal-resolution ERP measures of brain activity during two behavioral tasks. The first task, a modified Erikson flanker paradigm (with congruent and incongruent trials), was used to evoke the classic RT and ERP effects associated with conflict. In the second, a non-conflict comparison condition, participants visually discriminated a single stimulus (with easy and hard discrimination conditions). Behaviorally, the parameters were titrated to yield similar RT effects of conflict and difficulty (27 ms). Neurally, both within-task contrasts showed an initial fronto-central negative-polarity wave (N2-latency effect), but they then diverged. In the difficulty difference wave, the initial negativity led directly into the posterior LPC, whereas in the incongruency contrast the initial negativity was followed a by a second fronto-central negative peak (Ninc), which was then followed by a considerably longer-latency LPC. These results provide clear evidence that the longer processing for incongruent stimulus inputs do not just reflect time-on-task or difficulty, but include a true conflict-processing component. PMID:28017818

Electromechanical response times in the knee muscles in young and old women.

PubMed

Szpala, Agnieszka; Rutkowska-Kucharska, Alicja

2017-12-01

The aim of the study was to compare electromechanical response times [total reaction time (TRT), pre-motor time (PMT), and electromechanical delay] in the knee muscles in groups of young and older women during release of peak torque (PT). Fifty women (1 group approximately 20 years of age and the other approximately 60 years of age) participated in the study. PT and electromyographic activity were measured for flexors and extensors of the right and left knee in static conditions in response to a visual stimulus. Significantly longer TRTs (P = 0.05) and PMTs (P = 0.05) were found in the group of older women compared with the younger participants. Asymmetry was found between the older and the younger group of women in PT of knee flexors. Significantly longer TRT and PMT phases in the group of older women suggests a longer time for information processing in the central nervous system in older people. Muscle Nerve 56: E147-E153, 2017. © 2017 Wiley Periodicals, Inc.

Dispersibility of lactose fines as compared to API in dry powders for inhalation.

PubMed

Thalberg, Kyrre; Åslund, Simon; Skogevall, Marcus; Andersson, Patrik

2016-05-17

This work investigates the dispersion performance of fine lactose particles as function of processing time, and compares it to the API, using Beclomethasone Dipropionate (BDP) as model API. The total load of fine particles is kept constant in the formulations while the proportions of API and lactose fines are varied. Fine particle assessment demonstrates that the lactose fines have higher dispersibility than the API. For standard formulations, processing time has a limited effect on the Fine Particle Fraction (FPF). For formulations containing magnesium stearate (MgSt), FPF of BDP is heavily influenced by processing time, with an initial increase, followed by a decrease at longer mixing times. An equation modeling the observed behavior is presented. Surprisingly, the dispersibility of the lactose fines present in the same formulation remains unaffected by mixing time. Magnesium analysis demonstrates that MgSt is transferred to the fine particles during the mixing process, thus lubrication both BDP and lactose fines, which leads to an increased FPF. Dry particle sizing of the formulations reveals a loss of fine particles at longer mixing times. Incorporation of fine particles into the carrier surfaces is believed to be behind this, and is hence a mechanism of importance as regards the dispersion performance of dry powders for inhalation. Copyright © 2016 Elsevier B.V. All rights reserved.

Expansion and Compression of Time Correlate with Information Processing in an Enumeration Task.

PubMed

Wutz, Andreas; Shukla, Anuj; Bapi, Raju S; Melcher, David

2015-01-01

Perception of temporal duration is subjective and is influenced by factors such as attention and context. For example, unexpected or emotional events are often experienced as if time subjectively expands, suggesting that the amount of information processed in a unit of time can be increased. Time dilation effects have been measured with an oddball paradigm in which an infrequent stimulus is perceived to last longer than standard stimuli in the rest of the sequence. Likewise, time compression for the oddball occurs when the duration of the standard items is relatively brief. Here, we investigated whether the amount of information processing changes when time is perceived as distorted. On each trial, an oddball stimulus of varying numerosity (1-14 items) and duration was presented along with standard items that were either short (70 ms) or long (1050 ms). Observers were instructed to count the number of dots within the oddball stimulus and to judge its relative duration with respect to the standards on that trial. Consistent with previous results, oddballs were reliably perceived as temporally distorted: expanded for longer standard stimuli blocks and compressed for shorter standards. The occurrence of these distortions of time perception correlated with perceptual processing; i.e. enumeration accuracy increased when time was perceived as expanded and decreased with temporal compression. These results suggest that subjective time distortions are not epiphenomenal, but reflect real changes in sensory processing. Such short-term plasticity in information processing rate could be evolutionarily advantageous in optimizing perception and action during critical moments.

Fluctuation analysis of proficient and dysgraphic handwriting in children

NASA Astrophysics Data System (ADS)

Rosenblum, S.; Roman, H. E.

2009-03-01

We analyze handwriting records from several school children with the aim of characterizing the fluctuating behavior of the writing speed. It will be concluded that remarkable differences exist between proficient and dysgraphic handwritings which were unknown so far. It is shown that in the case of proficient handwriting, the variations in handwriting speed are strongly autocorrelated within times corresponding to the completion of a single character or letter, while become uncorrelated at longer times. In the case of dysgraphia, such correlations persist on longer time scales and the autocorrelation function seems to display algebraic time decay, indicating the presence of strong anomalies in the handwriting process. Applications of the results in educational/clinical programs are envisaged.

Enhancing The Army Operations Process Through The Incorportation of Holography

DTIC Science & Technology

2017-06-09

the process and gives the user the sense of a noninvasive enhancement to quickly make decisions . Processes and information no longer create...mentally overlaying it onto the process . Data now augments reality and is a noninvasive process to decision making . v ACKNOWLEDGMENTS This paper...environment, augmented on top of reality decreases the amount of time needed to make decisions

45 CFR 5.35 - Time limits.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Time limits. 5.35 Section 5.35 Public Welfare... Denial of Records § 5.35 Time limits. (a) General. FOIA sets certain time limits for us to decide whether... time limits, but if it appears that processing your request may take longer than we would wish, we will...

45 CFR 5.35 - Time limits.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 45 Public Welfare 1 2014-10-01 2014-10-01 false Time limits. 5.35 Section 5.35 Public Welfare... Denial of Records § 5.35 Time limits. (a) General. FOIA sets certain time limits for us to decide whether... time limits, but if it appears that processing your request may take longer than we would wish, we will...

45 CFR 5.35 - Time limits.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 1 2011-10-01 2011-10-01 false Time limits. 5.35 Section 5.35 Public Welfare... Denial of Records § 5.35 Time limits. (a) General. FOIA sets certain time limits for us to decide whether... time limits, but if it appears that processing your request may take longer than we would wish, we will...

45 CFR 5.35 - Time limits.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 45 Public Welfare 1 2012-10-01 2012-10-01 false Time limits. 5.35 Section 5.35 Public Welfare... Denial of Records § 5.35 Time limits. (a) General. FOIA sets certain time limits for us to decide whether... time limits, but if it appears that processing your request may take longer than we would wish, we will...

45 CFR 5.35 - Time limits.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 1 2013-10-01 2013-10-01 false Time limits. 5.35 Section 5.35 Public Welfare... Denial of Records § 5.35 Time limits. (a) General. FOIA sets certain time limits for us to decide whether... time limits, but if it appears that processing your request may take longer than we would wish, we will...

An improved processible acetylene-terminated polyimide for composites

NASA Technical Reports Server (NTRS)

Landis, A. L.; Naselow, A. B.

1985-01-01

The newest member of a family of thermosetting acetylene-substituted polyimide oligomers is HR600P. This oligomer is the isoimide version of the oligomer known as HR600P and Thermid 600. Although both types of material yield the same heat resistant end products after cure, HR600P has much superior processing characteristics. This attributed to its lower melting temperature (160 + or - 10 C, 320 + or - 20 F) in contrast to 202 C (396 F) for Thermid MC-600, its longer gel time at its processing temperature (16 to 30 minutes bvs 3 minutes), and its excellent solubility in low boiling solvents such as tetrahydrofuran, glymes, or 4:1 methyl ethyl ketone/toluene mixtures. These advantages provide more acceptable coating and impregnation procedures, allow for more complete removal at lower temperatures, provide a longer pot life or working time, and allow composite structure fabrication in conventional autoclaves used for epoxy composite curing. The excellent processing characteristics of HR600P allow its use in large area laminated structures, structural composites, and molding compositions.

The determinants of response time in a repeated constant-sum game: A robust Bayesian hierarchical dual-process model.

PubMed

Spiliopoulos, Leonidas

2018-03-01

The investigation of response time and behavior has a long tradition in cognitive psychology, particularly for non-strategic decision-making. Recently, experimental economists have also studied response time in strategic interactions, but with an emphasis on either one-shot games or repeated social-dilemmas. I investigate the determinants of response time in a repeated (pure-conflict) game, admitting a unique mixed strategy Nash equilibrium, with fixed partner matching. Response times depend upon the interaction of two decision models embedded in a dual-process framework (Achtziger and Alós-Ferrer, 2014; Alós-Ferrer, 2016). The first decision model is the commonly used win-stay/lose-shift heuristic and the second the pattern-detecting reinforcement learning model in Spiliopoulos (2013b). The former is less complex and can be executed more quickly than the latter. As predicted, conflict between these two models (i.e., each one recommending a different course of action) led to longer response times than cases without conflict. The dual-process framework makes other qualitative response time predictions arising from the interaction between the existence (or not) of conflict and which one of the two decision models the chosen action is consistent with-these were broadly verified by the data. Other determinants of RT were hypothesized on the basis of existing theory and tested empirically. Response times were strongly dependent on the actions chosen by both players in the previous rounds and the resulting outcomes. Specifically, response time was shortest after a win in the previous round where the maximum possible payoff was obtained; response time after losses was significantly longer. Strongly auto-correlated behavior (regardless of its sign) was also associated with longer response times. I conclude that, similar to other tasks, there is a strong coupling in repeated games between behavior and RT, which can be exploited to further our understanding of decision making. Copyright © 2017 Elsevier B.V. All rights reserved.

Delays in Referral and Enrolment Are Associated With Mitigated Benefits of Cardiac Rehabilitation After Coronary Artery Bypass Surgery.

PubMed

Marzolini, Susan; Blanchard, Chris; Alter, David A; Grace, Sherry L; Oh, Paul I

2015-11-01

Cardiac rehabilitation (CR) is recommended after coronary artery bypass graft surgery; however, the consequences of longer wait times to start CR have not been elucidated. Cardiopulmonary, demographic, and anthropometric assessments were conducted before and after 6 months of CR in consecutively enrolled patients from January 1995 to October 2012. Wait times were ascertained from referral forms and charts. Neighborhood characteristics were ascertained using census data and cross-referencing with patients' home geographic location. Among 6497 post- coronary artery bypass graft participants, mean and median total wait time (time from surgery to first exercise session) was 101.1±47.9 and 80 days, respectively. In multiple linear regression, correlates of longer total wait time and the 2 wait-time phases, time from surgery to CR referral and time from CR referral to first exercise session, were determined. Factors influencing longer wait times included female sex, greater age, being employed, less social support, longer drive time to CR, lower neighborhood socioeconomic status, higher systolic blood pressure, abdominal obesity, and a complex medical history. After adjusting for correlates of delayed entry, longer wait time for each of the total and 2 wait-time phases was significantly associated with less improvement in cardiopulmonary fitness (VO2peak; β=-0.165, P<0.001), body fat percentage (β=0.032, P<0.02), resting heart rate (β=0.066, P<0.001), and poorer attendance to CR classes (β=-0.081, P<0.001) and completion rate (β=2.741, P<0.001). Strategies for timely access to CR at each phase of the process are important given the negative impact that wait time has on key clinical outcomes. This is relevant because optimizing VO2peak and attendance to CR has been shown to confer a mortality advantage. © 2015 American Heart Association, Inc.

Elaborative rehearsal of nontemporal information interferes with temporal processing of durations in the range of seconds but not milliseconds.

PubMed

Rammsayer, Thomas; Ulrich, Rolf

2011-05-01

The distinct timing hypothesis suggests a sensory mechanism for processing of durations in the range of milliseconds and a cognitively controlled mechanism for processing of longer durations. To test this hypothesis, we employed a dual-task approach to investigate the effects of maintenance and elaborative rehearsal on temporal processing of brief and long durations. Unlike mere maintenance rehearsal, elaborative rehearsal as a secondary task involved transfer of information from working to long-term memory and elaboration of information to enhance storage in long-term memory. Duration discrimination of brief intervals was not affected by a secondary cognitive task that required either maintenance or elaborative rehearsal. Concurrent elaborative rehearsal, however, impaired discrimination of longer durations as compared to maintenance rehearsal and a control condition with no secondary task. These findings endorse the distinct timing hypothesis and are in line with the notion that executive functions, such as continuous memory updating and active transfer of information into long-term memory interfere with temporal processing of durations in the second, but not in the millisecond range. 2011 Elsevier B.V. All rights reserved.

Pretreatment effects on orange processing waste for making ethanol by simultaneous saccharification and fermentation

USDA-ARS?s Scientific Manuscript database

Pretreatment of orange processing waste (CPW) by steam explosion under various conditions (pretreatment time, pH and temperatures) was investigated. Pretreatments longer than 4 min with steam purging resulted in CPW containing less than 0.1% limonene, an inhibitor for fermentation. Steam pretreatmen...

Reorganization in Semantic Memory: An Interpretation of the Facilitation Effect

ERIC Educational Resources Information Center

Hopf-Weichel, Rosemarie

1977-01-01

A model is proposed in which information processing is accompanied by dynamic processes, including the reorganization of items into active patterns and their subsequent displacement. Research using category names and instances showed that reaction times decreased with each successive repetition under one condition, but longer latencies were…

A Theory of Reading: From Eye Fixations to Comprehension.

ERIC Educational Resources Information Center

Just, Marcel Adam; Carpenter, Patricia A.

1980-01-01

A model of reading comprehension focuses on eye fixations, which are related to the level of reading processes--words, clauses, and text units. Longer pauses are associated with greater processing difficulty. This model is illustrated for a group of undergraduate students reading scientific articles from "Newsweek" and "Time" magazines. (GDC)

Silicanizing Process On Mild Steel Substrate by Using Tronoh Silica Sand: Microstructure, composition and coating growth

NASA Astrophysics Data System (ADS)

Y, Yusnenti F. M.; M, Othman; Mustapha, Mazli; I, MohdYusri

2016-02-01

A new Silicanizing process on formation of coating on mild steel using Tronoh Silica Sand (TSS) is presented. The process was performed in the temperature range 1000- 1100°C and with varying deposition time of 1-4 hours. Influence of the layer and the substrate constituents on the coating compatibility of the whole silicanized layer is described in detail. Morphology and structure of the silicanized layer were investigated by XRF, XRD and SEM. It is observed that diffusion coatings containing high concentrations of silica which profile distribution of SiO2 in the silicanized layer was encountered and the depth from the surface to the substrate was taken as the layer thickness. The results also depicted that a longer deposition time have tendency to produce a looser and larger grain a hence rougher layer. The silicanized layer composed of FeSi and Fe2SiO4 phases with preferred orientation within the experimental range. It is also found that longer deposition time and higher temperature resulted in an increase in SiO2 concentration on the substrate (mild steel).

Time Processing in Dyscalculia

PubMed Central

Cappelletti, Marinella; Freeman, Elliot D.; Butterworth, Brian L.

2011-01-01

To test whether atypical number development may affect other types of quantity processing, we investigated temporal discrimination in adults with developmental dyscalculia (DD). This also allowed us to test whether number and time may be sub-served by a common quantity system or decision mechanisms: if they do, both should be impaired in dyscalculia, but if number and time are distinct they should dissociate. Participants judged which of two successively presented horizontal lines was longer in duration, the first line being preceded by either a small or a large number prime (“1” or “9”) or by a neutral symbol (“#”), or in a third task participants decided which of two Arabic numbers (either “1,” “5,” “9”) lasted longer. Results showed that (i) DD’s temporal discriminability was normal as long as numbers were not part of the experimental design, even as task-irrelevant stimuli; however (ii) task-irrelevant numbers dramatically disrupted DD’s temporal discriminability the more their salience increased, though the actual magnitude of the numbers had no effect; in contrast (iii) controls’ time perception was robust to the presence of numbers but modulated by numerical quantity: therefore small number primes or numerical stimuli seemed to make durations appear shorter than veridical, but longer for larger numerical prime or numerical stimuli. This study is the first to show spared temporal discrimination – a dimension of continuous quantity – in a population with a congenital number impairment. Our data reinforce the idea of a partially shared quantity system across numerical and temporal dimensions, which supports both dissociations and interactions among dimensions; however, they suggest that impaired number in DD is unlikely to originate from systems initially dedicated to continuous quantity processing like time. PMID:22194731

Time processing in dyscalculia.

PubMed

Cappelletti, Marinella; Freeman, Elliot D; Butterworth, Brian L

2011-01-01

To test whether atypical number development may affect other types of quantity processing, we investigated temporal discrimination in adults with developmental dyscalculia (DD). This also allowed us to test whether number and time may be sub-served by a common quantity system or decision mechanisms: if they do, both should be impaired in dyscalculia, but if number and time are distinct they should dissociate. Participants judged which of two successively presented horizontal lines was longer in duration, the first line being preceded by either a small or a large number prime ("1" or "9") or by a neutral symbol ("#"), or in a third task participants decided which of two Arabic numbers (either "1," "5," "9") lasted longer. Results showed that (i) DD's temporal discriminability was normal as long as numbers were not part of the experimental design, even as task-irrelevant stimuli; however (ii) task-irrelevant numbers dramatically disrupted DD's temporal discriminability the more their salience increased, though the actual magnitude of the numbers had no effect; in contrast (iii) controls' time perception was robust to the presence of numbers but modulated by numerical quantity: therefore small number primes or numerical stimuli seemed to make durations appear shorter than veridical, but longer for larger numerical prime or numerical stimuli. This study is the first to show spared temporal discrimination - a dimension of continuous quantity - in a population with a congenital number impairment. Our data reinforce the idea of a partially shared quantity system across numerical and temporal dimensions, which supports both dissociations and interactions among dimensions; however, they suggest that impaired number in DD is unlikely to originate from systems initially dedicated to continuous quantity processing like time.

How to keep cool in tough times.

PubMed

Muller-Smith, P

1999-02-01

Reengineering is no longer an event that has a beginning and an end. It is an ongoing process of change that continues to occur in all types of businesses. Because there is no longer the sense of security that doing a job well will guarantee continued employment, workers have to approach career planning from a different perspective. Moving up the career ladder in a single organization can no longer serve as the benchmark of success. The contemporary approach to success will be more geared toward the ability to constantly reinvent your unique set of job skills that are transferable from one job setting to another, thus ensuring employability.

Tracking the time course of multi-word noun phrase production with ERPs or on when (and why) cat is faster than the big cat.

PubMed

Bürki, Audrey; Laganaro, Marina

2014-01-01

Words are rarely produced in isolation. Yet, our understanding of multi-word production, and especially its time course, is still rather poor. In this research, we use event-related potentials to examine the production of multi-word noun phrases in the context of overt picture naming. We track the processing costs associated with the production of these noun phrases as compared with the production of bare nouns, from picture onset to articulation. Behavioral results revealed longer naming latencies for French noun phrases with determiners and pre-nominal adjectives (D-A-N, the big cat) than for noun phrases with a determiner (D-N, the cat), or bare nouns (N, cat). The spatio-temporal analysis of the ERPs revealed differences in the duration of stable global electrophysiological patterns as a function of utterance format in two time windows, from ~190 to 300 ms after picture onset, and from ~530 ms after picture onset to 100 ms before articulation. These findings can be accommodated in the following model. During grammatical encoding (here from ~190 to 300 ms), the noun and adjective lemmas are accessed in parallel, followed by the selection of the gender-agreeing determiner. Phonological encoding (after ~530 ms) operates sequentially. As a consequence, the phonological encoding process is longer for longer utterances. In addition, when determiners are repeated across trials, their phonological encoding can be anticipated or primed, resulting in a shortened encoding process.

The Time Factor: Leveraging Intelligent Agents and Directed Narratives in Online Learning Environments

ERIC Educational Resources Information Center

Jones, Greg; Warren, Scott

2009-01-01

Using video games, virtual simulations, and other digital spaces for learning can be a time-consuming process; aside from technical issues that may absorb class time, students take longer to achieve gains in learning in virtual environments. Greg Jones and Scott Warren describe how intelligent agents, in-game characters that respond to the context…

Vertical forearc tectonic displacements offer insights into underlying interplate thrust zone processes: 104-105 yr uplift/subsidence cycles in Southwest Pacific arcs may represent recoverable plastic deformation that is often falsely attributed to other causes

NASA Astrophysics Data System (ADS)

Taylor, F. W.; Lavier, L. L.; Frohlich, C.; Thirumalai, K.; Papabatu, A. K.

2015-12-01

In the forearcs of subduction zones, the characteristics of both short-term (temporary earthquake cycle) and longer-term permanent vertical deformation offer insights into processes by which plates subduct. But permanent vertical deformation may be a product of several simultaneous processes, including tectonic erosion/underplating, changing dip of the slab, upward displacement due to buoyancy or bathymetric features, and plastic shortening/extension of the forearc wedge. Here we note the rarely recognized, but possibly common, phenomenon of intermediate time scale transient vertical movements (TVM's). Both the central New Hebrides and Western Solomon forearcs have uplifted ≥500 m over time scales of 105 yr. Uplift started abruptly (over ≤10 ky) and proceeded at localized rates up to 7-8 mm/yr. Both initial uplifts terminated preceding rapid subsidence of similar dimensions and rates that, in turn, had followed yet older uplift. However, these uplifts and subsidences are superimposed on a yet longer-term trend of uplift on time scales >105 yr. The most recent uplifts extended 100-200 km along-arc and 60-90 km cross-arc while plate convergence was <10 km. These 105 yr vertical oscillations are most likely due to plastic shortening/extension driven by strong horizontal forces related to rugged seafloor bathymetry impinging on the outer forearc. Subsidence follows uplift when horizontal force abates temporarily and uplift is no longer supported by enhanced interplate coupling. Over the 105 yr time frame when interplate slip is <10 km, it is difficult to account for the timing, geography, and amounts of up and down motion by processes such as buoyancy or volumetric displacement of downgoing bathymetric features or by tectonic underplating/erosion. Instead, ~1% of shortening within the upper plate is sufficient to account for up to several hundred m of uplift across a large area of the forearc.

String-like collective motion in the α- and β-relaxation of a coarse-grained polymer melt

NASA Astrophysics Data System (ADS)

Pazmiño Betancourt, Beatriz A.; Starr, Francis W.; Douglas, Jack F.

2018-03-01

Relaxation in glass-forming liquids occurs as a multi-stage hierarchical process involving cooperative molecular motion. First, there is a "fast" relaxation process dominated by the inertial motion of the molecules whose amplitude grows upon heating, followed by a longer time α-relaxation process involving both large-scale diffusive molecular motion and momentum diffusion. Our molecular dynamics simulations of a coarse-grained glass-forming polymer melt indicate that the fast, collective motion becomes progressively suppressed upon cooling, necessitating large-scale collective motion by molecular diffusion for the material to relax approaching the glass-transition. In each relaxation regime, the decay of the collective intermediate scattering function occurs through collective particle exchange motions having a similar geometrical form, and quantitative relationships are derived relating the fast "stringlet" collective motion to the larger scale string-like collective motion at longer times, which governs the temperature-dependent activation energies associated with both thermally activated molecular diffusion and momentum diffusion.

Effect of processing methods on the mechanical properties of natural rubber filled with stearic acid modified soy protein particles

USDA-ARS?s Scientific Manuscript database

Natural rubber was reinforced with stearic acid modified soy protein particles prepared with a microfluidizing and ball milling process. Longer ball milling time tends to increase tensile strength of the rubber composites. Elastic modulus of the composites increased with the increasing filler concen...

Coal liquefaction process

DOEpatents

Carr, Norman L.; Moon, William G.; Prudich, Michael E.

1983-01-01

A C.sub.5 -900.degree. F. (C.sub.5 -482.degree. C.) liquid yield greater than 50 weight percent MAF feed coal is obtained in a coal liquefaction process wherein a selected combination of higher hydrogen partial pressure, longer slurry residence time and increased recycle ash content of the feed slurry are controlled within defined ranges.

Slow Cortical Dynamics and the Accumulation of Information over Long Timescales

PubMed Central

Honey, Christopher J.; Thesen, Thomas; Donner, Tobias H.; Silbert, Lauren J.; Carlson, Chad E.; Devinsky, Orrin; Doyle, Werner K.; Rubin, Nava; Heeger, David J.; Hasson, Uri

2012-01-01

SUMMARY Making sense of the world requires us to process information over multiple timescales. We sought to identify brain regions that accumulate information over short and long timescales and to characterize the distinguishing features of their dynamics. We recorded electrocorticographic (ECoG) signals from individuals watching intact and scrambled movies. Within sensory regions, fluctuations of high-frequency (64–200 Hz) power reliably tracked instantaneous low-level properties of the intact and scrambled movies. Within higher order regions, the power fluctuations were more reliable for the intact movie than the scrambled movie, indicating that these regions accumulate information over relatively long time periods (several seconds or longer). Slow (<0.1 Hz) fluctuations of high-frequency power with time courses locked to the movies were observed throughout the cortex. Slow fluctuations were relatively larger in regions that accumulated information over longer time periods, suggesting a connection between slow neuronal population dynamics and temporally extended information processing. PMID:23083743

Identifying DNA methylation in a nanochannel

NASA Astrophysics Data System (ADS)

Sun, Xiaoyin; Yasui, Takao; Yanagida, Takeshi; Kaji, Noritada; Rahong, Sakon; Kanai, Masaki; Nagashima, Kazuki; Kawai, Tomoji; Baba, Yoshinobu

2016-01-01

DNA methylation is a stable epigenetic modification, which is well known to be involved in gene expression regulation. In general, however, analyzing DNA methylation requires rather time consuming processes (24-96 h) via DNA replication and protein modification. Here we demonstrate a methodology to analyze DNA methylation at a single DNA molecule level without any protein modifications by measuring the contracted length and relaxation time of DNA within a nanochannel. Our methodology is based on the fact that methylation makes DNA molecules stiffer, resulting in a longer contracted length and a longer relaxation time (a slower contraction rate). The present methodology offers a promising way to identify DNA methylation without any protein modification at a single DNA molecule level within 2 h.

Time scales of tunneling decay of a localized state

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ban, Yue; Muga, J. G.; Sherman, E. Ya.

2010-12-15

Motivated by recent time-domain experiments on ultrafast atom ionization, we analyze the transients and time scales that characterize, aside from the relatively long lifetime, the decay of a localized state by tunneling. While the tunneling starts immediately, some time is required for the outgoing flux to develop. This short-term behavior depends strongly on the initial state. For the initial state, tightly localized so that the initial transients are dominated by over-the-barrier motion, the time scale for flux propagation through the barrier is close to the Buettiker-Landauer traversal time. Then a quasistationary, slow-decay process follows, which sets ideal conditions for observingmore » diffraction in time at longer times and distances. To define operationally a tunneling time at the barrier edge, we extrapolate backward the propagation of the wave packet that escaped from the potential. This extrapolated time is considerably longer than the time scale of the flux and density buildup at the barrier edge.« less

The influence of commenting validity, placement, and style on perceptions of computer code trustworthiness: A heuristic-systematic processing approach.

PubMed

Alarcon, Gene M; Gamble, Rose F; Ryan, Tyler J; Walter, Charles; Jessup, Sarah A; Wood, David W; Capiola, August

2018-07-01

Computer programs are a ubiquitous part of modern society, yet little is known about the psychological processes that underlie reviewing code. We applied the heuristic-systematic model (HSM) to investigate the influence of computer code comments on perceptions of code trustworthiness. The study explored the influence of validity, placement, and style of comments in code on trustworthiness perceptions and time spent on code. Results indicated valid comments led to higher trust assessments and more time spent on the code. Properly placed comments led to lower trust assessments and had a marginal effect on time spent on code; however, the effect was no longer significant after controlling for effects of the source code. Low style comments led to marginally higher trustworthiness assessments, but high style comments led to longer time spent on the code. Several interactions were also found. Our findings suggest the relationship between code comments and perceptions of code trustworthiness is not as straightforward as previously thought. Additionally, the current paper extends the HSM to the programming literature. Copyright © 2018 Elsevier Ltd. All rights reserved.

The Relaxation of Vicinal (001) with ZigZag [110] Steps

NASA Astrophysics Data System (ADS)

Hawkins, Micah; Hamouda, Ajmi Bh; González-Cabrera, Diego Luis; Einstein, Theodore L.

2012-02-01

This talk presents a kinetic Monte Carlo study of the relaxation dynamics of [110] steps on a vicinal (001) simple cubic surface. This system is interesting because [110] steps have different elementary excitation energetics and favor step diffusion more than close-packed [100] steps. In this talk we show how this leads to relaxation dynamics showing greater fluctuations on a shorter time scale for [110] steps as well as 2-bond breaking processes being rate determining in contrast to 3-bond breaking processes for [100] steps. The existence of a steady state is shown via the convergence of terrace width distributions at times much longer than the relaxation time. In this time regime excellent fits to the modified generalized Wigner distribution (as well as to the Berry-Robnik model when steps can overlap) were obtained. Also, step-position correlation function data show diffusion-limited increase for small distances along the step as well as greater average step displacement for zigzag steps compared to straight steps for somewhat longer distances along the step. Work supported by NSF-MRSEC Grant DMR 05-20471 as well as a DOE-CMCSN Grant.

Being In-Between: Reflecting on Time, Space and Career during the Tenure Application Process

ERIC Educational Resources Information Center

Eichler, Mathew

2015-01-01

Part of the process of becoming a tenured faculty member is applying for tenure. This reflective essay reports on the period after the submission of tenure materials for review but before the review process for tenure is completed. This is an "in-between" space, where the race of the tenure track is no longer present, but the role of…

Simplifying anemia management in hemodialysis patients: ESAs administered at longer dosing intervals can enhance opportunities to provide patient-focused care.

PubMed

Schiller, Brigitte; Besarab, Anatole

2011-08-01

To review issues and challenges in caring for hemodialysis patients with anemia of chronic kidney disease, specifically focusing on the effects of longer erythropoiesis-stimulating agent (ESA) dosing intervals on processes of care. PubMed searches were performed limited to the last 10 years to February 2011, focusing on articles in English that were 'clinical trials,' assessed processes of care, measured associations of hemoglobin (Hb) with outcomes, and explored/analyzed extended dosing intervals of ESAs in hemodialysis patients and recommendations for increasing the quality of care of these patients. Some limitations included the fact that a meta-analysis was not conducted; many studies were associative and therefore unable to prove causality; and none of the clinical trials directly compared the impact of more frequent or less frequent ESA dosing strategies on patient care and outcomes. Progress over the past several decades has been substantial; however, unmet needs remain and there is room for improvement in efficiencies of care. Many patients fail to meet Hb targets, and nephrology professionals' time is consumed with preparing, administering, and monitoring therapy. Direct interaction between patients and care providers has been lost as attention has shifted to 'cost-effective' (not necessarily patient-centered) ways to deliver care. Use of ESAs at longer dosage intervals represents one opportunity to improve efficiency of care. Newer ESAs have been developed for less frequent dosing. Once-monthly dosing decreases time spent administering/monitoring therapy and allows nephrology professionals to provide comprehensive renal care, wherein the patient rather than task-oriented processes becomes the primary focus. A fragmented, uncoordinated care-delivery model heightens the urgency to systematically address issues related to delivery of care and improve efficiencies in anemia management as part of the patient-centered approach. ESAs designed for administration at longer intervals may effectively and reliably achieve Hb targets with once-monthly dosing, thereby decreasing time spent administering/monitoring therapy.

An ERP Study of the Processing of Subject and Object Relative Clauses in Japanese

ERIC Educational Resources Information Center

Ueno, Mieko; Garnsey, Susan M.

2008-01-01

Using reading times and event-related brain potentials (ERPs), we investigated the processing of Japanese subject and object relative clauses (SRs/ORs). Previous research on English relative clauses shows that ORs take longer to read (King & Just, 1991) and elicit anterior negativity between fillers and gaps (King & Kutas, 1995), which is…

An Action Research on Deep Word Processing Strategy Instruction

ERIC Educational Resources Information Center

Zhang, Limei

2010-01-01

For too long a time, how to memorize more words and keep them longer in mind has been a primary and everlasting problem for vocabulary teaching and learning. This study focused on deep processing as a word memorizing strategy in contextualizing, de- and re- contextualizing learning stages. It also examined possible effects of such pedagogy on…

A unified theory for systems and cellular memory consolidation.

PubMed

Dash, Pramod K; Hebert, April E; Runyan, Jason D

2004-04-01

The time-limited role of the hippocampus for explicit memory storage has been referred to as systems consolidation where learning-related changes occur first in the hippocampus followed by the gradual development of a more distributed memory trace in the neocortex. Recent experiments are beginning to show that learning induces plasticity-related molecular changes in the neocortex as well as in the hippocampus and with a similar time course. Present memory consolidation theories do not account for these findings. In this report, we present a theory (the C theory) that incorporates these new findings, provides an explanation for the length of time for hippocampal dependency, and that can account for the apparent longer consolidation periods in species with larger brains. This theory proposes that a process of cellular consolidation occurs in the hippocampus and in areas of the neocortex during and shortly after learning resulting in long-term memory storage in both areas. For a limited time, the hippocampus is necessary for memory retrieval, a process involving the coordinated reactivation of these areas. This reactivation is later mediated by longer extrahippocampal connectivity between areas. The delay in hippocampal-independent memory retrieval is the time it takes for gene products in these longer extrahippocampal projections to be transported from the soma to tagged synapses by slow axonal transport. This cellular transport event defines the period of hippocampal dependency and, thus, the duration of memory consolidation. The theoretical description for memory consolidation presented in this review provides alternative explanations for several experimental observations and presents a unification of the concepts of systems and cellular memory consolidation.

Influence of time off feed on broiler viscera weight, diameter, and shear.

PubMed

Buhr, R J; Northcutt, J K; Lyon, C E; Rowland, G N

1998-05-01

The influence of time off feed on broiler viscera weight, intestinal diameter, and shear was studied by subjecting market-age male broilers (42, 44, or 48 d) to incremental feed withdrawal periods (0, 6, 12, 18, or 24 h). Body weight was determined prior to feed withdrawal and at the time of processing. After slaughter, scalding, and defeathering, the abdominal cavity was opened. Diameter and shear of the proventriculus-ventriculus junction, jejunum, and ileum segments were measured, as were gallbladder length and width. Thoracic and abdominal viscera, liver, and ventriculus weights were determined, and liver surface color was measured. Percentage body weight loss increased with longer feed withdrawal periods, as viscera, liver, and ventriculus weights decreased. Gallbladder length increased with time off feed, whereas its width did not change. Diameter of the proventriculus-ventriculus junction, jejunum, and ileum decreased with longer feed withdrawal periods. Shear values for the proventriculus-ventriculus junction, jejunum, and ileum were not influenced by time off feed. Positive correlations (P < 0.05 and r > 0.4) between viscera weight and intestinal diameter were detected. Correlations between all measured parameters and shear values were not significant. Liver color measurements indicated that longer feed withdrawal periods resulted in significant linear decreases in L* (lightness), +a* (redness), and +b* (yellowness). Longer feed withdrawal periods decreased viscera weight and intestinal diameter, which would lower the potential for cutting the intestine during automated evisceration. However, the resulting greater gallbladder length (5 mm) would increase the possibility of bile contamination during evisceration.

Licensing of future mobile satellite systems

NASA Technical Reports Server (NTRS)

Lepkowski, Ronald J.

1990-01-01

The regulatory process for licensing mobile satellite systems is complex and can require many years to complete. This process involves frequency allocations, national licensing, and frequency coordination. The regulatory process that resulted in the establishment of the radiodetermination satellite service (RDSS) between 1983 and 1987 is described. In contrast, each of these steps in the licensing of the mobile satellite service (MSS) is taking a significantly longer period of time to complete.

36 CFR 1220.18 - What definitions apply to the regulations in subchapter B?

Code of Federal Regulations, 2010 CFR

2010-07-01

... designed to furnish the information necessary to protect the legal and financial rights of the Government... time in the future. Disposition means those actions taken regarding records no longer needed for the... processing of records which need to be preserved for varying periods of time and need not be retained in...

36 CFR 1220.18 - What definitions apply to the regulations in Subchapter B?

Code of Federal Regulations, 2011 CFR

2011-07-01

... designed to furnish the information necessary to protect the legal and financial rights of the Government... time in the future. Disposition means those actions taken regarding records no longer needed for the... processing of records which need to be preserved for varying periods of time and need not be retained in...

Orthopaedic Device Approval Through the Premarket Approval Process: A Financial Feasibility Analysis for a Single Center.

PubMed

Yang, Brian W; Iorio, Matthew L; Day, Charles S

2017-03-15

The 2 main routes of medical device approval through the U.S. Food and Drug Administration are the premarket approval (PMA) process, which requires clinical trials, and the 510(k) premarket notification, which exempts devices from clinical trials if they are substantially equivalent to an existing device. Recently, there has been growing concern regarding the safety of devices approved through the 510(k) premarket notification. The PMA process decreases the potential for device recall; however, it is substantially more costly and time-consuming. Investors and medical device companies are only willing to invest in devices if they can expect to recoup their investment within a timeline of roughly 7 years. Our study utilizes financial modeling to assess the financial feasibility of approving various orthopaedic medical devices through the 510(k) and PMA processes. The expected time to recoup investment through the 510(k) process ranged from 0.585 years to 7.715 years, with an average time of 2.4 years; the expected time to recoup investment through the PMA route ranged from 2.9 years to 24.5 years, with an average time of 8.5 years. Six of the 13 orthopaedic device systems that we analyzed would require longer than our 7-year benchmark to recoup the investment costs of the PMA process. With the 510(k) premarket notification, only 1 device system would take longer than 7 years to recoup its investment costs. Although the 510(k) premarket notification has demonstrated safety concerns, broad requirements for PMA authorization may limit device innovation for less-prevalent orthopaedic conditions. As a result, new approval frameworks may be beneficial. Our report demonstrates how current regulatory policies can potentially influence orthopaedic device innovation.

Impact of backwashing procedures on deep bed filtration productivity in drinking water treatment.

PubMed

Slavik, Irene; Jehmlich, Alexander; Uhl, Wolfgang

2013-10-15

Backwash procedures for deep bed filters were evaluated and compared by means of a new integrated approach based on productivity. For this, different backwash procedures were experimentally evaluated by using a pilot plant for direct filtration. A standard backwash mode as applied in practice served as a reference and effluent turbidity was used as the criterion for filter run termination. The backwash water volumes needed, duration of the filter-to-waste period, time out of operation, total volume discharged and filter run-time were determined and used to calculate average filtration velocity and average productivity. Results for filter run-times, filter backwash volumes, and filter-to-waste volumes showed considerable differences between the backwash procedures. Thus, backwash procedures with additional clear flushing phases were characterised by an increased need for backwash water. However, this additional water consumption could not be compensated by savings during filter ripening. Compared to the reference backwash procedure, filter run-times were longer for both single-media and dual-media filters when air scour and air/water flush were optimised with respect to flow rates and the proportion of air and water. This means that drinking water production time is longer and less water is needed for filter bed cleaning. Also, backwashing with additional clear flushing phases resulted in longer filter run-times before turbidity breakthrough. However, regarding the productivity of the filtration process, it was shown that it was almost the same for all of the backwash procedures investigated in this study. Due to this unexpected finding, the relationships between filter bed cleaning, filter ripening and filtration performance were considered and important conclusions and new approaches for process optimisation and resource savings were derived. Copyright © 2013 Elsevier Ltd. All rights reserved.

File text security using Hybrid Cryptosystem with Playfair Cipher Algorithm and Knapsack Naccache-Stern Algorithm

NASA Astrophysics Data System (ADS)

Amalia; Budiman, M. A.; Sitepu, R.

2018-03-01

Cryptography is one of the best methods to keep the information safe from security attack by unauthorized people. At present, Many studies had been done by previous researchers to generate a more robust cryptographic algorithm to provide high security for data communication. To strengthen data security, one of the methods is hybrid cryptosystem method that combined symmetric and asymmetric algorithm. In this study, we observed a hybrid cryptosystem method contain Modification Playfair Cipher 16x16 algorithm as a symmetric algorithm and Knapsack Naccache-Stern as an asymmetric algorithm. We observe a running time of this hybrid algorithm with some of the various experiments. We tried different amount of characters to be tested which are 10, 100, 1000, 10000 and 100000 characters and we also examined the algorithm with various key’s length which are 10, 20, 30, 40 of key length. The result of our study shows that the processing time for encryption and decryption process each algorithm is linearly proportional, it means the longer messages character then, the more significant times needed to encrypt and decrypt the messages. The encryption running time of Knapsack Naccache-Stern algorithm takes a longer time than its decryption, while the encryption running time of modification Playfair Cipher 16x16 algorithm takes less time than its decryption.

Eye movements in pedophiles: automatic and controlled attentional processes while viewing prepubescent stimuli.

PubMed

Fromberger, Peter; Jordan, Kirsten; Steinkrauss, Henrike; von Herder, Jakob; Stolpmann, Georg; Kröner-Herwig, Birgit; Müller, Jürgen Leo

2013-05-01

Recent theories in sexuality highlight the importance of automatic and controlled attentional processes in viewing sexually relevant stimuli. The model of Spiering and Everaerd (2007) assumes that sexually relevant features of a stimulus are preattentively selected and automatically induce focal attention to these sexually relevant aspects. Whether this assumption proves true for pedophiles is unknown. It is aim of this study to test this assumption empirically for people suffering from pedophilic interests. Twenty-two pedophiles, 8 nonpedophilic forensic controls, and 52 healthy controls simultaneously viewed the picture of a child and the picture of an adult while eye movements were measured. Entry time was assessed as a measure of automatic attentional processes and relative fixation time in order to assess controlled attentional processes. Pedophiles demonstrated significantly shorter entry time to child stimuli than to adult stimuli. The opposite was the case for nonpedophiles, as they showed longer relative fixation time for adult stimuli, and, against all expectations, pedophiles also demonstrated longer relative fixation time for adult stimuli. The results confirmed the hypothesis that pedophiles automatically selected sexually relevant stimuli (children). Contrary to all expectations, this automatic selection did not trigger the focal attention to these sexually relevant pictures. Furthermore, pedophiles were first and longest attracted by faces and pubic regions of children; nonpedophiles were first and longest attracted by faces and breasts of adults. The results demonstrated, for the first time, that the face and pubic region are the most attracting regions in children for pedophiles. © 2013 American Psychological Association

Improvements in Operational Readiness by Distributing Manufacturing Capability in the Supply Chain through Additive Manufacturing

DTIC Science & Technology

2017-12-01

inefficiencies of a more complex system. Additional time may also be due to the longer distances traveled . The fulfillment time for a requisition to...Approved OMB No. 0704-0188 Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time ...advanced manufacturing methods with additive manufacturing. This work decomposes the additive manufacturing processes into 11 primary functions. The time

A carbon dioxide stripping model for mammalian cell culture in manufacturing scale bioreactors.

PubMed

Xing, Zizhuo; Lewis, Amanda M; Borys, Michael C; Li, Zheng Jian

2017-06-01

Control of carbon dioxide within the optimum range is important in mammalian bioprocesses at the manufacturing scale in order to ensure robust cell growth, high protein yields, and consistent quality attributes. The majority of bioprocess development work is done in laboratory bioreactors, in which carbon dioxide levels are more easily controlled. Some challenges in carbon dioxide control can present themselves when cell culture processes are scaled up, because carbon dioxide accumulation is a common feature due to longer gas-residence time of mammalian cell culture in large scale bioreactors. A carbon dioxide stripping model can be used to better understand and optimize parameters that are critical to cell culture processes at the manufacturing scale. The prevailing carbon dioxide stripping models in literature depend on mass transfer coefficients and were applicable to cell culture processes with low cell density or at stationary/cell death phase. However, it was reported that gas bubbles are saturated with carbon dioxide before leaving the culture, which makes carbon dioxide stripping no longer depend on a mass transfer coefficient in the new generation cell culture processes characterized by longer exponential growth phase, higher peak viable cell densities, and higher specific production rate. Here, we present a new carbon dioxide stripping model for manufacturing scale bioreactors, which is independent of carbon dioxide mass transfer coefficient, but takes into account the gas-residence time and gas CO 2 saturation time. The model was verified by CHO cell culture processes with different peak viable cell densities (7 to 12 × 10 6  cells mL -1 ) for two products in 5,000-L and 25,000-L bioreactors. The model was also applied to a next generation cell culture process to optimize cell culture conditions and reduce carbon dioxide levels at manufacturing scale. The model provides a useful tool to understand and better control cell culture carbon dioxide profiles for process development, scale up, and characterization. Biotechnol. Bioeng. 2017;114: 1184-1194. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

Improving preanalytic processes using the principles of lean production (Toyota Production System).

PubMed

Persoon, Thomas J; Zaleski, Sue; Frerichs, Janice

2006-01-01

The basic technologies used in preanalytic processes for chemistry tests have been mature for a long time, and improvements in preanalytic processes have lagged behind improvements in analytic and postanalytic processes. We describe our successful efforts to improve chemistry test turnaround time from a central laboratory by improving preanalytic processes, using existing resources and the principles of lean production. Our goal is to report 80% of chemistry tests in less than 1 hour and to no longer recognize a distinction between expedited and routine testing. We used principles of lean production (the Toyota Production System) to redesign preanalytic processes. The redesigned preanalytic process has fewer steps and uses 1-piece flow to move blood samples through the accessioning, centrifugation, and aliquoting processes. Median preanalytic processing time was reduced from 29 to 19 minutes, and the laboratory met the goal of reporting 80% of chemistry results in less than 1 hour for 11 consecutive months.

Weak ergodicity breaking, irreproducibility, and ageing in anomalous diffusion processes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Metzler, Ralf

2014-01-14

Single particle traces are standardly evaluated in terms of time averages of the second moment of the position time series r(t). For ergodic processes, one can interpret such results in terms of the known theories for the corresponding ensemble averaged quantities. In anomalous diffusion processes, that are widely observed in nature over many orders of magnitude, the equivalence between (long) time and ensemble averages may be broken (weak ergodicity breaking), and these time averages may no longer be interpreted in terms of ensemble theories. Here we detail some recent results on weakly non-ergodic systems with respect to the time averagedmore » mean squared displacement, the inherent irreproducibility of individual measurements, and methods to determine the exact underlying stochastic process. We also address the phenomenon of ageing, the dependence of physical observables on the time span between initial preparation of the system and the start of the measurement.« less

Older adults' attentional deployment: Differential gaze patterns for different negative mood states.

PubMed

Demeyer, Ineke; Sanchez, Alvaro; De Raedt, Rudi

2017-06-01

Older adults are characterized by an attentional preference for positive over negative information. Since this positivity effect is considered to be an emotion regulation strategy, it should be more pronounced when emotion regulation is needed. In contrast to previous studies that focused on the effects of sad mood on attention, we used a stressor to activate emotion regulation and evaluate the effects of different types of mood state changes. Moreover, we evaluated mood effects on attentional processes using a paradigm that allows disentangling between different attentional engagement and disengagement processes. Sixty older adults were randomly assigned to receive a stressor or a control task. Before and after this manipulation, mood state levels (happy, sad, nervous, calm) were assessed. Next, attentional processing of happy, sad, and angry faces was investigated using an eye-tracking paradigm in which participants had to either engage their attention towards or disengage their attention away from emotional stimuli. Changes in different mood state levels were associated with different attentional disengagement strategies. As expected, older adults who increased in sad mood level showed a larger positivity effect as evidenced by a longer time to disengage attention from happy faces. However, older adults who received the tension induction and who decreased in calm mood level were characterized by longer times to disengage attention from sad faces. The stressor was only partially effective as it led to changes in calm mood, but not in nervous mood. These results suggest that older adults may deploy a positivity effect in attention (i.e., longer times to disengage from positive information) in order to regulate sad mood, but that this effect may be hampered during the confrontation with stressors. Copyright © 2016 Elsevier Ltd. All rights reserved.

The Effect of Stimulus Valence on Lexical Retrieval in Younger and Older Adults.

PubMed

Blackett, Deena Schwen; Harnish, Stacy M; Lundine, Jennifer P; Zezinka, Alexandra; Healy, Eric W

2017-07-12

Although there is evidence that emotional valence of stimuli impacts lexical processes, there is limited work investigating its specific impact on lexical retrieval. The current study aimed to determine the degree to which emotional valence of pictured stimuli impacts naming latencies in healthy younger and older adults. Eighteen healthy younger adults and 18 healthy older adults named positive, negative, and neutral images, and reaction time was measured. Reaction times for positive and negative images were significantly longer than reaction times for neutral images. Reaction times for positive and negative images were not significantly different. Whereas older adults demonstrated significantly longer naming latencies overall than younger adults, the discrepancy in latency with age was far greater when naming emotional pictures. Emotional arousal of pictures appears to impact naming latency in younger and older adults. We hypothesize that the increase in naming latency for emotional stimuli is the result of a necessary disengagement of attentional resources from the emotional images prior to completion of the naming task. We propose that this process may affect older adults disproportionately due to a decline in attentional resources as part of normal aging, combined with a greater attentional preference for emotional stimuli.

A Proof of Factorization Theorem of Drell-Yan Process at Operator Level

NASA Astrophysics Data System (ADS)

Zhou, Gao-Liang

2016-02-01

An alternative proof of factorization theorem for Drell-Yan process that works at operator level is presented in this paper. Contributions of interactions after the hard collision for such inclusive processes are proved to be canceled at operator level according to the unitarity of time evolution operator. After this cancellation, there are no longer leading pinch singular surface in Glauber region in the time evolution of electromagnetic currents. Effects of soft gluons are absorbed into Wilson lines of scalar-polarized gluons. Cancelation of soft gluons is attribute to unitarity of time evolution operator and such Wilson lines. Supported by the National Natural Science Foundation of China under Grant No. 11275242

Search time critically depends on irrelevant subset size in visual search.

PubMed

Benjamins, Jeroen S; Hooge, Ignace T C; van Elst, Jacco C; Wertheim, Alexander H; Verstraten, Frans A J

2009-02-01

In order for our visual system to deal with the massive amount of sensory input, some of this input is discarded, while other parts are processed [Wolfe, J. M. (1994). Guided search 2.0: a revised model of visual search. Psychonomic Bulletin and Review, 1, 202-238]. From the visual search literature it is unclear how well one set of items can be selected that differs in only one feature from target (a 1F set), while another set of items can be ignored that differs in two features from target (a 2F set). We systematically varied the percentage of 2F non-targets to determine the contribution of these non-targets to search behaviour. Increasing the percentage 2F non-targets, that have to be ignored, was expected to result in increasingly faster search, since it decreases the size of 1F set that has to be searched. Observers searched large displays for a target in the 1F set with a variable percentage of 2F non-targets. Interestingly, when the search displays contained 5% 2F non-targets, the search time was longer compared to the search time in other conditions. This effect of 2F non-targets on performance was independent of set size. An inspection of the saccades revealed that saccade target selection did not contribute to the longer search times in displays with 5% 2F non-targets. Occurrence of longer search times in displays containing 5% 2F non-targets might be attributed to covert processes related to visual analysis of the fixated part of the display. Apparently, visual search performance critically depends on the percentage of irrelevant 2F non-targets.

A neuromorphic circuit mimicking biological short-term memory.

PubMed

Barzegarjalali, Saeid; Parker, Alice C

2016-08-01

Research shows that the way we remember things for a few seconds is a different mechanism from the way we remember things for a longer time. Short-term memory is based on persistently firing neurons, whereas storing information for a longer time is based on strengthening the synapses or even forming new neural connections. Information about location and appearance of an object is segregated and processed by separate neurons. Furthermore neurons can continue firing using different mechanisms. Here, we have designed a biomimetic neuromorphic circuit that mimics short-term memory by firing neurons, using biological mechanisms to remember location and shape of an object. Our neuromorphic circuit has a hybrid architecture. Neurons are designed with CMOS 45nm technology and synapses are designed with carbon nanotubes (CNT).

Stable and verifiable state estimation methods and systems with spacecraft applications

NASA Technical Reports Server (NTRS)

Li, Rongsheng (Inventor); Wu, Yeong-Wei Andy (Inventor)

2001-01-01

The stability of a recursive estimator process (e.g., a Kalman filter is assured for long time periods by periodically resetting an error covariance P(t.sub.n) of the system to a predetermined reset value P.sub.r. The recursive process is thus repetitively forced to start from a selected covariance and continue for a time period that is short compared to the system's total operational time period. The time period in which the process must maintain its numerical stability is significantly reduced as is the demand on the system's numerical stability. The process stability for an extended operational time period T.sub.o is verified by performing the resetting step at the end of at least one reset time period T.sub.r whose duration is less than the operational time period T.sub.o and then confirming stability of the process over the reset time period T.sub.r. Because the recursive process starts from a selected covariance at the beginning of each reset time period T.sub.r, confirming stability of the process over at least one reset time period substantially confirms stability over the longer operational time period T.sub.o.

Effects of musical training on sound pattern processing in high-school students.

PubMed

Wang, Wenjung; Staffaroni, Laura; Reid, Errold; Steinschneider, Mitchell; Sussman, Elyse

2009-05-01

Recognizing melody in music involves detection of both the pitch intervals and the silence between sequentially presented sounds. This study tested the hypothesis that active musical training in adolescents facilitates the ability to passively detect sequential sound patterns compared to musically non-trained age-matched peers. Twenty adolescents, aged 15-18 years, were divided into groups according to their musical training and current experience. A fixed order tone pattern was presented at various stimulus rates while electroencephalogram was recorded. The influence of musical training on passive auditory processing of the sound patterns was assessed using components of event-related brain potentials (ERPs). The mismatch negativity (MMN) ERP component was elicited in different stimulus onset asynchrony (SOA) conditions in non-musicians than musicians, indicating that musically active adolescents were able to detect sound patterns across longer time intervals than age-matched peers. Musical training facilitates detection of auditory patterns, allowing the ability to automatically recognize sequential sound patterns over longer time periods than non-musical counterparts.

Chain-Length-Dependent Exciton Dynamics in Linear Oligothiophenes Probed Using Ensemble and Single-Molecule Spectroscopy.

PubMed

Kim, Tae-Woo; Kim, Woojae; Park, Kyu Hyung; Kim, Pyosang; Cho, Jae-Won; Shimizu, Hideyuki; Iyoda, Masahiko; Kim, Dongho

2016-02-04

Exciton dynamics in π-conjugated molecular systems is highly susceptible to conformational disorder. Using time-resolved and single-molecule spectroscopic techniques, the effect of chain length on the exciton dynamics in a series of linear oligothiophenes, for which the conformational disorder increased with increasing chain length, was investigated. As a result, extraordinary features of the exciton dynamics in longer-chain oligothiophene were revealed. Ultrafast fluorescence depolarization processes were observed due to exciton self-trapping in longer and bent chains. Increase in exciton delocalization during dynamic planarization processes was also observed in the linear oligothiophenes via time-resolved fluorescence spectra but was restricted in L-10T because of its considerable conformational disorder. Exciton delocalization was also unexpectedly observed in a bent chain using single-molecule fluorescence spectroscopy. Such delocalization modulates the fluorescence spectral shape by attenuating the 0-0 peak intensity. Collectively, these results provide significant insights into the exciton dynamics in conjugated polymers.

Head and Eye Movements Affect Object Processing in 4-Month-Old Infants More than an Artificial Orientation Cue

ERIC Educational Resources Information Center

Wahl, Sebastian; Michel, Christine; Pauen, Sabina; Hoehl, Stefanie

2013-01-01

This study investigates the effects of attention-guiding stimuli on 4-month-old infants' object processing. In the human head condition, infants saw a person turning her head and eye gaze towards or away from objects. When presented with the objects again, infants showed increased attention in terms of longer looking time measured by eye…

Cancel and rethink in the Wason selection task: further evidence for the heuristic-analytic dual process theory.

PubMed

Wada, Kazushige; Nittono, Hiroshi

2004-06-01

The reasoning process in the Wason selection task was examined by measuring card inspection times in the letter-number and drinking-age problems. 24 students were asked to solve the problems presented on a computer screen. Only the card touched with a mouse pointer was visible, and the total exposure time of each card was measured. Participants were allowed to cancel their previous selections at any time. Although rethinking was encouraged, the cards once selected were rarely cancelled (10% of the total selections). Moreover, most of the cancelled cards were reselected (89% of the total cancellations). Consistent with previous findings, inspection times were longer for selected cards than for nonselected cards. These results suggest that card selections are determined largely by initial heuristic processes and rarely reversed by subsequent analytic processes. The present study gives further support for the heuristic-analytic dual process theory.

Ultrafast dynamics of defect-assisted electron-hole recombination in monolayer MoS2.

PubMed

Wang, Haining; Zhang, Changjian; Rana, Farhan

2015-01-14

In this Letter, we present nondegenerate ultrafast optical pump-probe studies of the carrier recombination dynamics in MoS2 monolayers. By tuning the probe to wavelengths much longer than the exciton line, we make the probe transmission sensitive to the total population of photoexcited electrons and holes. Our measurement reveals two distinct time scales over which the photoexcited electrons and holes recombine; a fast time scale that lasts ∼ 2 ps and a slow time scale that lasts longer than ∼ 100 ps. The temperature and the pump fluence dependence of the observed carrier dynamics are consistent with defect-assisted recombination as being the dominant mechanism for electron-hole recombination in which the electrons and holes are captured by defects via Auger processes. Strong Coulomb interactions in two-dimensional atomic materials, together with strong electron and hole correlations in two-dimensional metal dichalcogenides, make Auger processes particularly effective for carrier capture by defects. We present a model for carrier recombination dynamics that quantitatively explains all features of our data for different temperatures and pump fluences. The theoretical estimates for the rate constants for Auger carrier capture are in good agreement with the experimentally determined values. Our results underscore the important role played by Auger processes in two-dimensional atomic materials.

A Comparative Study of Cyclic Oxidation and Sulfates-Induced Hot Corrosion Behavior of Arc-Sprayed Ni-Cr-Ti Coatings at Moderate Temperatures

NASA Astrophysics Data System (ADS)

Guo, Wenmin; Wu, Yuping; Zhang, Jianfeng; Hong, Sheng; Chen, Liyan; Qin, Yujiao

2015-06-01

The cyclic oxidation and sulfates-induced hot corrosion behaviors of a Ni-43Cr-0.3Ti arc-sprayed coating at 550-750 °C were characterized and compared in this study. In general, all the oxidation and hot corrosion kinetic curves of the coating followed a parabolic law, i.e., the weight of the specimens showed a rapid growth initially and then reached the gradual state. However, the initial stage of the hot corrosion process was approximately two times longer than that of the oxidation process, indicating a longer preparation time required for the formation of a protective scale in the former process. At 650 °C, the parabolic rate constant for the hot corrosion was 7.2 × 10-12 g2/(cm4·s), approximately 1.7 times higher than that for the oxidation at the same temperature. The lower parabolic rate constant for the oxidation was mainly attributed to the formation of a protective oxide scale on the surface of corroded specimens, which was composed of a mixture of NiO, Cr2O3, and NiCr2O4. However, as the liquid molten salts emerged during the hot corrosion, these protective oxides would be dissolved and the coating was corrupted acceleratedly.

Oscillatory multiphase flow strategy for chemistry and biology.

PubMed

Abolhasani, Milad; Jensen, Klavs F

2016-07-19

Continuous multiphase flow strategies are commonly employed for high-throughput parameter screening of physical, chemical, and biological processes as well as continuous preparation of a wide range of fine chemicals and micro/nano particles with processing times up to 10 min. The inter-dependency of mixing and residence times, and their direct correlation with reactor length have limited the adaptation of multiphase flow strategies for studies of processes with relatively long processing times (0.5-24 h). In this frontier article, we describe an oscillatory multiphase flow strategy to decouple mixing and residence times and enable investigation of longer timescale experiments than typically feasible with conventional continuous multiphase flow approaches. We review current oscillatory multiphase flow technologies, provide an overview of the advancements of this relatively new strategy in chemistry and biology, and close with a perspective on future opportunities.

Making the purchase decision: factors other than price.

PubMed

Lyons, D M

1992-05-01

Taking price out of the limelight and concentrating on customer relations, mutual respect, and build-in/buy-in; involving the user; developing communication and evaluation processes; and being process oriented to attain the results needed require commitment on the part of administration and materiel management. There must be a commitment of time to develop the process, commitment of resources to work through the process, and a commitment of support to enhance the process. With those three parameters in place, price will no longer be the only factor in the purchasing decision.

Educator Perceptions of Response to Intervention

ERIC Educational Resources Information Center

DeLoach, Darcia

2017-01-01

Response to Intervention (RTI) is a research-based process in which students are provided timely intensive interventions. No longer adopting "wait to fail" models, this paradigm shift has challenged educators to employ systematic mathematics interventions which has been reported as challenging to implement within high schools. Therefore,…

50 CFR 452.03 - Threshold review and determinations.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 9 2011-10-01 2011-10-01 false Threshold review and determinations. 452... PROCESS CONSIDERATION OF APPLICATION BY THE SECRETARY § 452.03 Threshold review and determinations. (a) Threshold determinations. Within 20 days after receiving an exemption application, or a longer time agreed...

50 CFR 452.03 - Threshold review and determinations.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 11 2014-10-01 2014-10-01 false Threshold review and determinations. 452... PROCESS CONSIDERATION OF APPLICATION BY THE SECRETARY § 452.03 Threshold review and determinations. (a) Threshold determinations. Within 20 days after receiving an exemption application, or a longer time agreed...

NPL-PAD (National Priorities List Publication Assistance Database) for Region 7

EPA Pesticide Factsheets

THIS DATA ASSET NO LONGER ACTIVE: This is metadata documentation for the National Priorities List (NPL) Publication Assistance Databsae (PAD), a Lotus Notes application that holds Region 7's universe of NPL site information such as site description, threats and contaminants, cleanup approach, environmental process, community involvement, site repository, and regional contacts. This database used to be updated annually, at different times for different NPLs, but it is currently no longer being used. This work fell under objectives for EPA's 2003-2008 Strategic Plan (Goal 3) for Land Preservation & Restoration, which are to clean up and reuse contaminated land.

The longer term experiences of parent training: a qualitative analysis.

PubMed

Furlong, M; McGilloway, S

2015-09-01

Child conduct problems are a major public health priority. Group-based parenting programmes are popular in addressing such problems, but evidence for their longer-term effectiveness is limited. Moreover, process evaluations are rare and little is understood about the key facilitative and inhibitive factors associated with maintaining outcomes in the longer term. This study involved the use of qualitative methods as part of a larger process evaluation to explore the longer-term experiences of parents who participated in a randomized controlled trial (RCT) of the Incredible Years Parenting Programme (IYPP) in disadvantaged settings in Ireland. A series of one-to-one in-depth interviews was conducted with parents at 12- (n = 20) and 18-month follow-up (n = 8) and analysed using constructivist grounded theory. Most parents reported positive child behaviour despite several challenges, but a substantial subset reported periods of relapse in positive outcomes. A relapse in child behaviour was linked to relinquishing skills in stressful times, the negative influence of an unsupportive environment, and the perceived ineffectiveness of parenting skills. Resilience in implementing skills despite adversity, and the utilization of available social supports, were associated with the maintenance of positive outcomes. Strengthening resilience and social support capacities may be important factors in maintaining positive longer-term outcomes. Those who design, research and deliver parenting programmes might consider the possibility of including a relapse-prevention module and/or the provision of post-intervention supports for more vulnerable families. © 2014 John Wiley & Sons Ltd.

Software Engineering and Its Application to Avionics

DTIC Science & Technology

1988-01-01

34Automated Software Development Methodolgy (ASDM): An Architecture of a Knowledge-Based Expert System," Masters Thesis , Florida Atlantic University, Boca...operating system provides the control semnrim and aplication services within the miltiproossur system. Them processes timt aks up the application sofhwae...as a high-value target may no longer be occupied by the time the film is processed and analyzed. With the high mobility of today’s enemy forces

Differential memory in the earth's magnetotail

NASA Technical Reports Server (NTRS)

Burkhart, G. R.; Chen, J.

1991-01-01

The process of 'differential memory' in the earth's magnetotail is studied in the framework of the modified Harris magnetotail geometry. It is verified that differential memory can generate non-Maxwellian features in the modified Harris field model. The time scales and the potentially observable distribution functions associated with the process of differential memory are investigated, and it is shown that non-Maxwelllian distributions can evolve as a test particle response to distribution function boundary conditions in a Harris field magnetotail model. The non-Maxwellian features which arise from distribution function mapping have definite time scales associated with them, which are generally shorter than the earthward convection time scale but longer than the typical Alfven crossing time.

Recent topographic evolution and erosion of the deglaciated Washington Cascades inferred from a stochastic landscape evolution model

NASA Astrophysics Data System (ADS)

Moon, Seulgi; Shelef, Eitan; Hilley, George E.

2015-05-01

In this study, we model postglacial surface processes and examine the evolution of the topography and denudation rates within the deglaciated Washington Cascades to understand the controls on and time scales of landscape response to changes in the surface process regime after deglaciation. The postglacial adjustment of this landscape is modeled using a geomorphic-transport-law-based numerical model that includes processes of river incision, hillslope diffusion, and stochastic landslides. The surface lowering due to landslides is parameterized using a physically based slope stability model coupled to a stochastic model of the generation of landslides. The model parameters of river incision and stochastic landslides are calibrated based on the rates and distribution of thousand-year-time scale denudation rates measured from cosmogenic 10Be isotopes. The probability distributions of those model parameters calculated based on a Bayesian inversion scheme show comparable ranges from previous studies in similar rock types and climatic conditions. The magnitude of landslide denudation rates is determined by failure density (similar to landslide frequency), whereas precipitation and slopes affect the spatial variation in landslide denudation rates. Simulation results show that postglacial denudation rates decay over time and take longer than 100 kyr to reach time-invariant rates. Over time, the landslides in the model consume the steep slopes characteristic of deglaciated landscapes. This response time scale is on the order of or longer than glacial/interglacial cycles, suggesting that frequent climatic perturbations during the Quaternary may produce a significant and prolonged impact on denudation and topography.

Managing Relations with Industry: The Case of Brazilian Universities

ERIC Educational Resources Information Center

Lahorgue, Maria Alice

2005-01-01

For a long time, university-business relations were a matter of individual, informal and intermittent contacts. Once the innovation process picked up speed, businesses began asking more from universities (longer-term co-operative research, for example), and governments placed university-business interaction at the centre of their innovation…

Effect of microfluidized and stearic acid modified soy protein in natural rubber

USDA-ARS?s Scientific Manuscript database

Microfluidized and stearic acid modified soy protein aggregates were used to reinforced natural rubber. The size of soy protein particles was reduced with a microfluidizing and ball milling process. Filler size reduction with longer ball milling time tends to increase tensile strength of the rubber ...

Music and Sound in Time Processing of Children with ADHD

PubMed Central

Carrer, Luiz Rogério Jorgensen

2015-01-01

ADHD involves cognitive and behavioral aspects with impairments in many environments of children and their families’ lives. Music, with its playful, spontaneous, affective, motivational, temporal, and rhythmic dimensions can be of great help for studying the aspects of time processing in ADHD. In this article, we studied time processing with simple sounds and music in children with ADHD with the hypothesis that children with ADHD have a different performance when compared with children with normal development in tasks of time estimation and production. The main objective was to develop sound and musical tasks to evaluate and correlate the performance of children with ADHD, with and without methylphenidate, compared to a control group with typical development. The study involved 36 participants of age 6–14 years, recruited at NANI-UNIFESP/SP, subdivided into three groups with 12 children in each. Data was collected through a musical keyboard using Logic Audio Software 9.0 on the computer that recorded the participant’s performance in the tasks. Tasks were divided into sections: spontaneous time production, time estimation with simple sounds, and time estimation with music. Results: (1) performance of ADHD groups in temporal estimation of simple sounds in short time intervals (30 ms) were statistically lower than that of control group (p < 0.05); (2) in the task comparing musical excerpts of the same duration (7 s), ADHD groups considered the tracks longer when the musical notes had longer durations, while in the control group, the duration was related to the density of musical notes in the track. The positive average performance observed in the three groups in most tasks perhaps indicates the possibility that music can, in some way, positively modulate the symptoms of inattention in ADHD. PMID:26441688

Music and Sound in Time Processing of Children with ADHD.

PubMed

Carrer, Luiz Rogério Jorgensen

2015-01-01

ADHD involves cognitive and behavioral aspects with impairments in many environments of children and their families' lives. Music, with its playful, spontaneous, affective, motivational, temporal, and rhythmic dimensions can be of great help for studying the aspects of time processing in ADHD. In this article, we studied time processing with simple sounds and music in children with ADHD with the hypothesis that children with ADHD have a different performance when compared with children with normal development in tasks of time estimation and production. The main objective was to develop sound and musical tasks to evaluate and correlate the performance of children with ADHD, with and without methylphenidate, compared to a control group with typical development. The study involved 36 participants of age 6-14 years, recruited at NANI-UNIFESP/SP, subdivided into three groups with 12 children in each. Data was collected through a musical keyboard using Logic Audio Software 9.0 on the computer that recorded the participant's performance in the tasks. Tasks were divided into sections: spontaneous time production, time estimation with simple sounds, and time estimation with music. (1) performance of ADHD groups in temporal estimation of simple sounds in short time intervals (30 ms) were statistically lower than that of control group (p < 0.05); (2) in the task comparing musical excerpts of the same duration (7 s), ADHD groups considered the tracks longer when the musical notes had longer durations, while in the control group, the duration was related to the density of musical notes in the track. The positive average performance observed in the three groups in most tasks perhaps indicates the possibility that music can, in some way, positively modulate the symptoms of inattention in ADHD.

VARTM Process Modeling of Aerospace Composite Structures

NASA Technical Reports Server (NTRS)

Song, Xiao-Lan; Grimsley, Brian W.; Hubert, Pascal; Cano, Roberto J.; Loos, Alfred C.

2003-01-01

A three-dimensional model was developed to simulate the VARTM composite manufacturing process. The model considers the two important mechanisms that occur during the process: resin flow, and compaction and relaxation of the preform. The model was used to simulate infiltration of a carbon preform with an epoxy resin by the VARTM process. The model predicted flow patterns and preform thickness changes agreed qualitatively with the measured values. However, the predicted total infiltration times were much longer than measured most likely due to the inaccurate preform permeability values used in the simulation.

Analysis of production flow process with lean manufacturing approach

NASA Astrophysics Data System (ADS)

Siregar, Ikhsan; Arif Nasution, Abdillah; Prasetio, Aji; Fadillah, Kharis

2017-09-01

This research was conducted on the company engaged in the production of Fast Moving Consumer Goods (FMCG). The production process in the company are still exists several activities that cause waste. Non value added activity (NVA) in the implementation is still widely found, so the cycle time generated to make the product will be longer. A form of improvement on the production line is by applying lean manufacturing method to identify waste along the value stream to find non value added activities. Non value added activity can be eliminated and reduced by utilizing value stream mapping and identifying it with activity mapping process. According to the results obtained that there are 26% of value-added activities and 74% non value added activity. The results obtained through the current state map of the production process of process lead time value of 678.11 minutes and processing time of 173.94 minutes. While the results obtained from the research proposal is the percentage of value added time of 41% of production process activities while non value added time of the production process of 59%. While the results obtained through the future state map of the production process of process lead time value of 426.69 minutes and processing time of 173.89 minutes.

Computational Fluid Dynamics Modeling of Supersonic Coherent Jets for Electric Arc Furnace Steelmaking Process

NASA Astrophysics Data System (ADS)

Alam, Morshed; Naser, Jamal; Brooks, Geoffrey; Fontana, Andrea

2010-12-01

Supersonic coherent gas jets are now used widely in electric arc furnace steelmaking and many other industrial applications to increase the gas-liquid mixing, reaction rates, and energy efficiency of the process. However, there has been limited research on the basic physics of supersonic coherent jets. In the present study, computational fluid dynamics (CFD) simulation of the supersonic jet with and without a shrouding flame at room ambient temperature was carried out and validated against experimental data. The numerical results show that the potential core length of the supersonic oxygen and nitrogen jet with shrouding flame is more than four times and three times longer, respectively, than that without flame shrouding, which is in good agreement with the experimental data. The spreading rate of the supersonic jet decreased dramatically with the use of the shrouding flame compared with a conventional supersonic jet. The present CFD model was used to investigate the characteristics of the supersonic coherent oxygen jet at steelmaking conditions of around 1700 K (1427 °C). The potential core length of the supersonic coherent oxygen jet at steelmaking conditions was 1.4 times longer than that at room ambient temperature.

The JCMT nearby galaxies legacy survey - X. Environmental effects on the molecular gas and star formation properties of spiral galaxies

NASA Astrophysics Data System (ADS)

Mok, Angus; Wilson, C. D.; Golding, J.; Warren, B. E.; Israel, F. P.; Serjeant, S.; Knapen, J. H.; Sánchez-Gallego, J. R.; Barmby, P.; Bendo, G. J.; Rosolowsky, E.; van der Werf, P.

2016-03-01

We present a study of the molecular gas properties in a sample of 98 H I - flux selected spiral galaxies within ˜25 Mpc, using the CO J = 3 - 2 line observed with the James Clerk Maxwell Telescope. We use the technique of survival analysis to incorporate galaxies with CO upper limits into our results. Comparing the group and Virgo samples, we find a larger mean H2 mass in the Virgo galaxies, despite their lower mean H I mass. This leads to a significantly higher H2 to H I ratio for Virgo galaxies. Combining our data with complementary Hα star formation rate measurements, Virgo galaxies have longer molecular gas depletion times compared to group galaxies, due to their higher H2 masses and lower star formation rates. We suggest that the longer depletion times may be a result of heating processes in the cluster environment or differences in the turbulent pressure. From the full sample, we find that the molecular gas depletion time has a positive correlation with the stellar mass, indicative of differences in the star formation process between low- and high-mass galaxies, and a negative correlation between the molecular gas depletion time and the specific star formation rate.

Efficiency of time-lapse intervals and simple baits for camera surveys of wild pigs

USGS Publications Warehouse

Williams, B.L.; Holtfreter, R.W.; Ditchkoff, S.S.; Grand, J.B.

2011-01-01

Growing concerns surrounding established and expanding populations of wild pigs (Sus scrofa) have created the need for rapid and accurate surveys of these populations. We conducted surveys of a portion of the wild pig population on Fort Benning, Georgia, to determine if a longer time-lapse interval than had been previously used in surveys of wild pigs would generate similar detection results. We concurrently examined whether use of soured corn at camera sites affected the time necessary for pigs to locate a new camera site or the time pigs remained at a site. Our results suggest that a 9-min time-lapse interval generated dependable detection results for pigs and that soured corn neither attracted pigs to a site any quicker than plain, dry, whole-kernel corn, nor held them at a site longer. Maximization of time-lapse interval should decrease data and processing loads, and use of a simple, available bait should decrease cost and effort associated with more complicated baits; combination of these concepts should increase efficiency of wild pig surveys. ?? 2011 The Wildlife Society.

Evaluative Processing of Food Images: A Conditional Role for Viewing in Preference Formation

PubMed Central

Wolf, Alexandra; Ounjai, Kajornvut; Takahashi, Muneyoshi; Kobayashi, Shunsuke; Matsuda, Tetsuya; Lauwereyns, Johan

2018-01-01

Previous research suggested a role of gaze in preference formation, not merely as an expression of preference, but also as a causal influence. According to the gaze cascade hypothesis, the longer subjects look at an item, the more likely they are to develop a preference for it. However, to date the connection between viewing and liking has been investigated predominately with self-paced viewing conditions in which the subjects were required to select certain items from simultaneously presented stimuli on the basis of perceived visual attractiveness. Such conditions might promote a default, but non-mandatory connection between viewing and liking. To explore whether the connection is separable, we examined the evaluative processing of single naturalistic food images in a 2 × 2 design, conducted completely within subjects, in which we varied both the type of exposure (self-paced versus time-controlled) and the type of evaluation (non-exclusive versus exclusive). In the self-paced exclusive evaluation, longer viewing was associated with a higher likelihood of a positive evaluation. However, in the self-paced non-exclusive evaluation, the trend reversed such that longer viewing durations were associated with lesser ratings. Furthermore, in the time-controlled tasks, both with non-exclusive and exclusive evaluation, there was no significant relationship between the viewing duration and the evaluation. The overall pattern of results was consistent for viewing times measured in terms of exposure duration (i.e., the duration of stimulus presentation on the screen) and in terms of actual gaze duration (i.e., the amount of time the subject effectively gazed at the stimulus on the screen). The data indicated that viewing does not intrinsically lead to a higher evaluation when evaluating single food images; instead, the relationship between viewing duration and evaluation depends on the type of task. We suggest that self-determination of exposure duration may be a prerequisite for any influence from viewing time on evaluative processing, regardless of whether the influence is facilitative. Moreover, the purported facilitative link between viewing and liking appears to be limited to exclusive evaluation, when only a restricted number of items can be included in a chosen set. PMID:29942273

Evaluative Processing of Food Images: A Conditional Role for Viewing in Preference Formation.

PubMed

Wolf, Alexandra; Ounjai, Kajornvut; Takahashi, Muneyoshi; Kobayashi, Shunsuke; Matsuda, Tetsuya; Lauwereyns, Johan

2018-01-01

Previous research suggested a role of gaze in preference formation, not merely as an expression of preference, but also as a causal influence. According to the gaze cascade hypothesis, the longer subjects look at an item, the more likely they are to develop a preference for it. However, to date the connection between viewing and liking has been investigated predominately with self-paced viewing conditions in which the subjects were required to select certain items from simultaneously presented stimuli on the basis of perceived visual attractiveness. Such conditions might promote a default, but non-mandatory connection between viewing and liking. To explore whether the connection is separable, we examined the evaluative processing of single naturalistic food images in a 2 × 2 design, conducted completely within subjects, in which we varied both the type of exposure (self-paced versus time-controlled) and the type of evaluation (non-exclusive versus exclusive). In the self-paced exclusive evaluation, longer viewing was associated with a higher likelihood of a positive evaluation. However, in the self-paced non-exclusive evaluation, the trend reversed such that longer viewing durations were associated with lesser ratings. Furthermore, in the time-controlled tasks, both with non-exclusive and exclusive evaluation, there was no significant relationship between the viewing duration and the evaluation. The overall pattern of results was consistent for viewing times measured in terms of exposure duration (i.e., the duration of stimulus presentation on the screen) and in terms of actual gaze duration (i.e., the amount of time the subject effectively gazed at the stimulus on the screen). The data indicated that viewing does not intrinsically lead to a higher evaluation when evaluating single food images; instead, the relationship between viewing duration and evaluation depends on the type of task. We suggest that self-determination of exposure duration may be a prerequisite for any influence from viewing time on evaluative processing, regardless of whether the influence is facilitative. Moreover, the purported facilitative link between viewing and liking appears to be limited to exclusive evaluation, when only a restricted number of items can be included in a chosen set.

Deep geothermal: The ‘Moon Landing’ mission in the unconventional energy and minerals space

DOE PAGES

Regenauer-Lieb, Klaus; Bunger, Andrew; Chua, Hui Tong; ...

2015-01-30

Deep geothermal from the hot crystalline basement has remained an unsolved frontier for the geothermal industry for the past 30 years. This poses the challenge for developing a new unconventional geomechanics approach to stimulate such reservoirs. While a number of new unconventional brittle techniques are still available to improve stimulation on short time scales, the astonishing richness of failure modes of longer time scales in hot rocks has so far been overlooked. These failure modes represent a series of microscopic processes: brittle microfracturing prevails at low temperatures and fairly high deviatoric stresses, while upon increasing temperature and decreasing applied stressmore » or longer time scales, the failure modes switch to transgranular and intergranular creep fractures. Accordingly, fluids play an active role and create their own pathways through facilitating shear localization by a process of time-dependent dissolution and precipitation creep, rather than being a passive constituent by simply following brittle fractures that are generated inside a shear zone caused by other localization mechanisms. We lay out a new paradigm for reservoir stimulation by reactivating pre-existing faults at reservoir scale in a reservoir scale aseismic, ductile manner. A side effect of the new “soft” stimulation method is that owing to the design specification of a macroscopic ductile response, the proposed method offers the potential of a safer control over the stimulation process compared to conventional stimulation protocols such as currently employed in shale gas reservoirs.« less

Improving Models for Coseismic And Postseismic Deformation from the 2002 Denali, Alaska Earthquake

NASA Astrophysics Data System (ADS)

Harper, H.; Freymueller, J. T.

2016-12-01

Given the multi-decadal temporal scale of postseismic deformation, predictions of previous models for postseismic deformation resulting from the 2002 Denali Fault earthquake (M 7.9) do not agree with longer-term observations. In revising the past postseismic models with what is now over a decade of data, the first step is revisiting coseismic displacements and slip distribution of the earthquake. Advances in processing allow us to better constrain coseismic displacement estimates, which affect slip distribution predictions in modeling. Additionally, an updated slip model structure from a homogeneous model to a layered model rectifies previous inconsistencies between coseismic and postseismic models. Previous studies have shown that two primary processes contribute to postseismic deformation: afterslip, which decays with a short time constant; and viscoelastic relaxation, which decays with a longer time constant. We fit continuous postseismic GPS time series with three different relaxation models: 1) logarithmic decay + exponential decay, 2) log + exp + exp, and 3) log + log + exp. A grid search is used to minimize total model WRSS, and we find optimal relaxation times of: 1) 0.125 years (log) and 21.67 years (exp); 2) 0.14 years (log), 0.68 years (exp), and 28.33 years (exp); 3) 0.055 years (log), 14.44 years (log), and 22.22 years (exp). While there is not a one-to-one correspondence between a particular decay constant and a mechanism, the optimization of these constants allows us to model the future timeseries and constrain the contribution of different postseismic processes.

Assessment of pedophilic sexual interest with an attentional choice reaction time task.

PubMed

Mokros, Andreas; Dombert, Beate; Osterheider, Michael; Zappalà, Angelo; Santtila, Pekka

2010-10-01

Choice-reaction time (CRT) is an experimental information-processing paradigm. Based on an interference effect in visual attention, the CRT method has been shown to be suitable for measuring sexual orientation in men and women. The present study assessed the potential of the CRT to identify deviant (i.e., pedophilic) sexual interest. Participants were patients from forensic-psychiatric hospitals: 21 child molesters and 21 non-sex offenders. The dependent variable was reaction time in an ostensible seek-and-locate task (i.e., identifying the position of a dot superimposed on a picture of a person). There was an interaction effect between stimulus age category and participant group status: Child molesters took longer to respond to pictures of children relative to pictures of adults. Non-sex offenders showed an opposite pattern (i.e., longer reaction times with pictures of adults than with pictures of children). In addition, the data supported the notion of sexual content induced delay: Subjects took longer for the task with nude stimuli than with clothed ones. A subtractive preference index, derived from the reaction times for child and adult stimulus material, allowed distinguishing participants from both groups almost perfectly (ROC-AUC = .998). We conclude that a match of sexual interest with properties of visual stimuli led to a cognitive interference effect: Attentional resources were drawn from the ostensible task of locating the dot towards exploring the picture. This opens up the possibility of using this interference effect (i.e., the delay of response times) for diagnostic purposes.

One and two-phonon processes of the spin-flip relaxation in quantum dots: Spin-phonon coupling mechanism

NASA Astrophysics Data System (ADS)

Wang, Zi-Wu; Li, Shu-Shen

2012-07-01

We investigate the spin-flip relaxation in quantum dots using a non-radiation transition approach based on the descriptions for the electron-phonon deformation potential and Fröhlich interaction in the Pavlov-Firsov spin-phonon Hamiltonian. We give the comparisons of the electron relaxations with and without spin-flip assisted by one and two-phonon processes. Calculations are performed for the dependence of the relaxation time on the external magnetic field, the temperature and the energy separation between the Zeeman sublevels of the ground and first-excited state. We find that the electron relaxation time of the spin-flip process is more longer by three orders of magnitudes than that of no spin-flip process.

Effect of the PreBind Engagement Process on Scrum Timing and Stability in the 2013 to 2016 Six Nations.

PubMed

Bradley, Edward J; Hogg, Bob; Archer, David T

2017-12-28

This study examined if changes in scrum engagement laws from the "crouch-touch-set" (CTS) in 2013 to the "PreBind" engagement from 2014 onwards have led to changes in scrum characteristics, specifically timing, in international rugby union. Duration and outcomes were identified for all scrums occurring in the 2013-2016 Six Nations (n=60 games) using video analysis. Scrum duration increased after the introduction of the PreBind engagement from 59 s in 2013 to 69 s in 2016 (ρ=0.024, ES 0.93). A significant increase in mean contact duration per scrum occurred when prebinding was adopted (ρ<0.05), moving from 7.5 s under the CTS process to 8.5, 10.0 and 10.8 s with PreBind in 2014, 2015 and 2016 (ES 0.71, 2.05 and 3.0, respectively). The number of scrum resets and collapsed scrums, along with early engagement and pulling down infringements were lower under the PreBind process. Overall, the PreBind engagement resulted in longer scrums with significant increases observed in overall and contact durations, with improved stability related characteristics. The longer contact time is a consequence of increased stability with a shift from high energy impact to a sustained push phase with a lower force that is a benefit to player welfare.

Thermal processing differentially affects lycopene and other carotenoids in cis-lycopene containing, tangerine tomatoes.

PubMed

Cooperstone, Jessica L; Francis, David M; Schwartz, Steven J

2016-11-01

Tangerine tomatoes, unlike red tomatoes, accumulate cis-lycopenes instead of the all-trans isomer. cis-Lycopene is the predominating isomeric form of lycopene found in blood and tissues. Our objective was to understand how thermal processing and lipid concentration affect carotenoid isomerisation and degradation in tangerine tomatoes. We conducted duplicated factorial designed experiments producing tangerine tomato juice and sauce, varying both processing time and lipid concentration. Carotenoids were extracted and analysed using high-performance liquid chromatography with photodiode array detection. Phytoene, phytofluene, ζ-carotene, neurosporene, tetra-cis-lycopene, all-trans-lycopene and other-cis-lycopenes were quantified. Tetra-cis-lycopene decreased with increasing heating time and reached 80% of the original level in sauce after processing times of 180min. All-trans-lycopene and other-cis-lycopenes increased with longer processing times. Total carotenoids and total lycopene decreased with increased heating times while phytoene and phytofluene were unchanged. These data suggest limiting thermal processing of tangerine tomato products if delivery of tetra-cis-lycopene is desirable. Copyright © 2016 Elsevier Ltd. All rights reserved.

An Integrated Model of Choices and Response Times in Absolute Identification

ERIC Educational Resources Information Center

Brown, Scott D.; Marley, A. A. J.; Donkin, Christopher; Heathcote, Andrew

2008-01-01

Recent theoretical developments in the field of absolute identification have stressed differences between relative and absolute processes, that is, whether stimulus magnitudes are judged relative to a shorter term context provided by recently presented stimuli or a longer term context provided by the entire set of stimuli. The authors developed a…

Character order processing in Chinese reading.

PubMed

Gu, Junjuan; Li, Xingshan; Liversedge, Simon P

2015-02-01

We explored how character order information is encoded in isolated word processing or Chinese sentence reading in 2 experiments using a masked priming paradigm and a gaze-contingent display-change paradigm. The results showed that response latencies in the lexical decision task and reading times on the target word region were longer in the unrelated condition (the prime or the preview was unrelated with the target word) than the transposed-character condition (the prime or the preview was a transposition of the 2 characters of the target word), which were respectively longer than in the identity condition (the prime or preview was identical to the target word). These results show that character order is encoded at an early stage of processing in Chinese reading, but character position encoding was not strict. We also found that character order encoding was similar for single-morpheme and multiple-morpheme words, suggesting that morphemic status does not affect character order encoding. The current results represent an early contribution to our understanding of character order encoding during Chinese reading.

Microwave processing of gustatory tissues for immunohistochemistry

PubMed Central

Bond, Amanda; Kinnamon, John C.

2013-01-01

We use immunohistochemistry to study taste cell structure and function as a means to elucidate how taste receptor cells communicate with nerve fibers and adjacent taste cells. This conventional method, however, is time consuming. In the present study we used taste buds from rat circumvallate papillae to compare conventional immunohistochemical tissue processing with microwave processing for the colocalization of several biochemical pathway markers (PLCβ2, syntaxin-1, IP3R3, α-gustducin) and the nuclear stain, Sytox. The results of our study indicate that in microwave versus conventional immunocytochemistry: (1) fixation quality is improved; (2) the amount of time necessary for processing tissue is decreased; (3) antigen retrieval is no longer needed; (4) image quality is superior. In sum, microwave tissue processing of gustatory tissues is faster and superior to conventional immunohistochemical tissue processing for many applications. PMID:23473796

Leaf phenological characters of main tree species in urban forest of Shenyang.

PubMed

Xu, Sheng; Xu, Wenduo; Chen, Wei; He, Xingyuan; Huang, Yanqing; Wen, Hua

2014-01-01

Plant leaves, as the main photosynthetic organs and the high energy converters among primary producers in terrestrial ecosystems, have attracted significant research attention. Leaf lifespan is an adaptive characteristic formed by plants to obtain the maximum carbon in the long-term adaption process. It determines important functional and structural characteristics exhibited in the environmental adaptation of plants. However, the leaf lifespan and leaf characteristics of urban forests were not studied up to now. By using statistic, linear regression methods and correlation analysis, leaf phenological characters of main tree species in urban forest of Shenyang were observed for five years to obtain the leafing phenology (including leafing start time, end time, and duration), defoliating phenology (including defoliation start time, end time, and duration), and the leaf lifespan of the main tree species. Moreover, the relationships between temperature and leafing phenology, defoliating phenology, and leaf lifespan were analyzed. The timing of leafing differed greatly among species. The early leafing species would have relatively early end of leafing; the longer it took to the end of leafing would have a later time of completed leafing. The timing of defoliation among different species varied significantly, the early defoliation species would have relatively longer duration of defoliation. If the mean temperature rise for 1°C in spring, the time of leafing would experience 5 days earlier in spring. If the mean temperature decline for 1°C, the time of defoliation would experience 3 days delay in autumn. There is significant correlation between leaf longevity and the time of leafing and defoliation. According to correlation analysis and regression analysis, there is significant correlation between temperature and leafing and defoliation phenology. Early leafing species would have a longer life span and consequently have advantage on carbon accumulation compared with later defoliation species.

Psychological and Neural Mechanisms of Subjective Time Dilation

PubMed Central

van Wassenhove, Virginie; Wittmann, Marc; Craig, A. D. (Bud); Paulus, Martin P.

2011-01-01

For a given physical duration, certain events can be experienced as subjectively longer in duration than others. Try this for yourself: take a quick glance at the second hand of a clock. Immediately, the tick will pause momentarily and appear to be longer than the subsequent ticks. Yet, they all last exactly 1 s. By and large, a deviant or an unexpected stimulus in a series of similar events (same duration, same features) can elicit a relative overestimation of subjective time (or “time dilation”) but, as is shown here, this is not always the case. We conducted an event-related functional magnetic neuroimaging study on the time dilation effect. Participants were presented with a series of five visual discs, all static and of equal duration (standards) except for the fourth one, a looming or a receding target. The duration of the target was systematically varied and participants judged whether it was shorter or longer than all other standards in the sequence. Subjective time dilation was observed for the looming stimulus but not for the receding one, which was estimated to be of equal duration to the standards. The neural activation for targets (looming and receding) contrasted with the standards revealed an increased activation of the anterior insula and of the anterior cingulate cortex. Contrasting the looming with the receding targets (i.e., capturing the time dilation effect proper) revealed a specific activation of cortical midline structures. The implication of midline structures in the time dilation illusion is here interpreted in the context of self-referential processes. PMID:21559346

Visual attention mechanisms in happiness versus trustworthiness processing of facial expressions.

PubMed

Calvo, Manuel G; Krumhuber, Eva G; Fernández-Martín, Andrés

2018-03-01

A happy facial expression makes a person look (more) trustworthy. Do perceptions of happiness and trustworthiness rely on the same face regions and visual attention processes? In an eye-tracking study, eye movements and fixations were recorded while participants judged the un/happiness or the un/trustworthiness of dynamic facial expressions in which the eyes and/or the mouth unfolded from neutral to happy or vice versa. A smiling mouth and happy eyes enhanced perceived happiness and trustworthiness similarly, with a greater contribution of the smile relative to the eyes. This comparable judgement output for happiness and trustworthiness was reached through shared as well as distinct attentional mechanisms: (a) entry times and (b) initial fixation thresholds for each face region were equivalent for both judgements, thereby revealing the same attentional orienting in happiness and trustworthiness processing. However, (c) greater and (d) longer fixation density for the mouth region in the happiness task, and for the eye region in the trustworthiness task, demonstrated different selective attentional engagement. Relatedly, (e) mean fixation duration across face regions was longer in the trustworthiness task, thus showing increased attentional intensity or processing effort.

Medial-Vowel Writing Difficulty in Korean Syllabic Writing: A Characteristic Sign of Alzheimer's Disease

PubMed Central

Yoon, Ji Hye; Jeong, Yong

2018-01-01

Background and Purpose Korean-speaking patients with a brain injury may show agraphia that differs from that of English-speaking patients due to the unique features of Hangul syllabic writing. Each grapheme in Hangul must be arranged from left to right and/or top to bottom within a square space to form a syllable, which requires greater visuospatial abilities than when writing the letters constituting an alphabetic writing system. Among the Hangul grapheme positions within a syllable, the position of a vowel is important because it determines the writing direction and the whole configuration in Korean syllabic writing. Due to the visuospatial characteristics of the Hangul vowel, individuals with early-onset Alzheimer's disease (EOAD) may experiences differences between the difficulties of writing Hangul vowels and consonants due to prominent visuospatial dysfunctions caused by parietal lesions. Methods Eighteen patients with EOAD and 18 age-and-education-matched healthy adults participated in this study. The participants were requested to listen to and write 30 monosyllabic characters that consisted of an initial consonant, medial vowel, and final consonant with a one-to-one phoneme-to-grapheme correspondence. We measured the writing time for each grapheme, the pause time between writing the initial consonant and the medial vowel (P1), and the pause time between writing the medial vowel and the final consonant (P2). Results All grapheme writing and pause times were significantly longer in the EOAD group than in the controls. P1 was also significantly longer than P2 in the EOAD group. Conclusions Patients with EOAD might require a higher judgment ability and longer processing time for determining the visuospatial grapheme position before writing medial vowels. This finding suggests that a longer pause time before writing medial vowels is an early marker of visuospatial dysfunction in patients with EOAD. PMID:29504296

Medial-Vowel Writing Difficulty in Korean Syllabic Writing: A Characteristic Sign of Alzheimer's Disease.

PubMed

Yoon, Ji Hye; Jeong, Yong; Na, Duk L

2018-04-01

Korean-speaking patients with a brain injury may show agraphia that differs from that of English-speaking patients due to the unique features of Hangul syllabic writing. Each grapheme in Hangul must be arranged from left to right and/or top to bottom within a square space to form a syllable, which requires greater visuospatial abilities than when writing the letters constituting an alphabetic writing system. Among the Hangul grapheme positions within a syllable, the position of a vowel is important because it determines the writing direction and the whole configuration in Korean syllabic writing. Due to the visuospatial characteristics of the Hangul vowel, individuals with early-onset Alzheimer's disease (EOAD) may experiences differences between the difficulties of writing Hangul vowels and consonants due to prominent visuospatial dysfunctions caused by parietal lesions. Eighteen patients with EOAD and 18 age-and-education-matched healthy adults participated in this study. The participants were requested to listen to and write 30 monosyllabic characters that consisted of an initial consonant, medial vowel, and final consonant with a one-to-one phoneme-to-grapheme correspondence. We measured the writing time for each grapheme, the pause time between writing the initial consonant and the medial vowel (P1), and the pause time between writing the medial vowel and the final consonant (P2). All grapheme writing and pause times were significantly longer in the EOAD group than in the controls. P1 was also significantly longer than P2 in the EOAD group. Patients with EOAD might require a higher judgment ability and longer processing time for determining the visuospatial grapheme position before writing medial vowels. This finding suggests that a longer pause time before writing medial vowels is an early marker of visuospatial dysfunction in patients with EOAD. Copyright © 2018 Korean Neurological Association.

Low power signal processing electronics for wearable medical devices.

PubMed

Casson, Alexander J; Rodriguez-Villegas, Esther

2010-01-01

Custom designed microchips, known as Application Specific Integrated Circuits (ASICs), offer the lowest possible power consumption electronics. However, this comes at the cost of a longer, more complex and more costly design process compared to one using generic, off-the-shelf components. Nevertheless, their use is essential in future truly wearable medical devices that must operate for long periods of time from physically small, energy limited batteries. This presentation will demonstrate the state-of-the-art in ASIC technology for providing online signal processing for use in these wearable medical devices.

An ordinary differential equation model for full thickness wounds and the effects of diabetes.

PubMed

Bowden, L G; Maini, P K; Moulton, D E; Tang, J B; Wang, X T; Liu, P Y; Byrne, H M

2014-11-21

Wound healing is a complex process in which a sequence of interrelated phases contributes to a reduction in wound size. For diabetic patients, many of these processes are compromised, so that wound healing slows down. In this paper we present a simple ordinary differential equation model for wound healing in which attention focusses on the dominant processes that contribute to closure of a full thickness wound. Asymptotic analysis of the resulting model reveals that normal healing occurs in stages: the initial and rapid elastic recoil of the wound is followed by a longer proliferative phase during which growth in the dermis dominates healing. At longer times, fibroblasts exert contractile forces on the dermal tissue, the resulting tension stimulating further dermal tissue growth and enhancing wound closure. By fitting the model to experimental data we find that the major difference between normal and diabetic healing is a marked reduction in the rate of dermal tissue growth for diabetic patients. The model is used to estimate the breakdown of dermal healing into two processes: tissue growth and contraction, the proportions of which provide information about the quality of the healed wound. We show further that increasing dermal tissue growth in the diabetic wound produces closure times similar to those associated with normal healing and we discuss the clinical implications of this hypothesised treatment. Copyright © 2014 Elsevier Ltd. All rights reserved.

Processing of Written Irony in Autism Spectrum Disorder: An Eye-Movement Study.

PubMed

Au-Yeung, Sheena K; Kaakinen, Johanna K; Liversedge, Simon P; Benson, Valerie

2015-12-01

Previous research has suggested that individuals with Autism Spectrum Disorders (ASD) have difficulties understanding others communicative intent and with using contextual information to correctly interpret irony. We recorded the eye movements of typically developing (TD) adults ASD adults when they read statements that could either be interpreted as ironic or non-ironic depending on the context of the passage. Participants with ASD performed as well as TD controls in their comprehension accuracy for speaker's statements in both ironic and non-ironic conditions. Eye movement data showed that for both participant groups, total reading times were longer for the critical region containing the speaker's statement and a subsequent sentence restating the context in the ironic condition compared to the non-ironic condition. The results suggest that more effortful processing is required in both ASD and TD participants for ironic compared with literal non-ironic statements, and that individuals with ASD were able to use contextual information to infer a non-literal interpretation of ironic text. Individuals with ASD, however, spent more time overall than TD controls rereading the passages, to a similar degree across both ironic and non-ironic conditions, suggesting that they either take longer to construct a coherent discourse representation of the text, or that they take longer to make the decision that their representation of the text is reasonable based on their knowledge of the world. © 2015 International Society for Autism Research, Wiley Periodicals, Inc.

Travel time and concurrent-schedule choice: retrospective versus prospective control.

PubMed

Davison, M; Elliffe, D

2000-01-01

Six pigeons were trained on concurrent variable-interval schedules in which two different travel times between alternatives, 4.5 and 0.5 s, were randomly arranged. In Part 1, the next travel time was signaled while the subjects were responding on each alternative. Generalized matching analyses of performance in the presence of the two travel-time signals showed significantly higher response and time sensitivity when the longer travel time was signaled compared to when the shorter time was signaled. When the data were analyzed as a function of the previous travel time, there were no differences in sensitivity. Dwell times on the alternatives were consistently longer in the presence of the stimulus that signaled the longer travel time than they were in the presence of the stimulus that signaled the shorter travel time. These results are in accord with a recent quantitative account of the effects of travel time. In Part 2, no signals indicating the next travel time were given. When these data were analyzed as a function of the previous travel time, time-allocation sensitivity after the 4.5-s travel time was significantly greater than that after the 0.5-s travel time, but no such difference was found for response allocation. Dwell times were also longer when the previous travel time had been longer.

Object Categorization in Finer Levels Relies More on Higher Spatial Frequencies and Takes Longer.

PubMed

Ashtiani, Matin N; Kheradpisheh, Saeed R; Masquelier, Timothée; Ganjtabesh, Mohammad

2017-01-01

The human visual system contains a hierarchical sequence of modules that take part in visual perception at different levels of abstraction, i.e., superordinate, basic, and subordinate levels. One important question is to identify the "entry" level at which the visual representation is commenced in the process of object recognition. For a long time, it was believed that the basic level had a temporal advantage over two others. This claim has been challenged recently. Here we used a series of psychophysics experiments, based on a rapid presentation paradigm, as well as two computational models, with bandpass filtered images of five object classes to study the processing order of the categorization levels. In these experiments, we investigated the type of visual information required for categorizing objects in each level by varying the spatial frequency bands of the input image. The results of our psychophysics experiments and computational models are consistent. They indicate that the different spatial frequency information had different effects on object categorization in each level. In the absence of high frequency information, subordinate and basic level categorization are performed less accurately, while the superordinate level is performed well. This means that low frequency information is sufficient for superordinate level, but not for the basic and subordinate levels. These finer levels rely more on high frequency information, which appears to take longer to be processed, leading to longer reaction times. Finally, to avoid the ceiling effect, we evaluated the robustness of the results by adding different amounts of noise to the input images and repeating the experiments. As expected, the categorization accuracy decreased and the reaction time increased significantly, but the trends were the same. This shows that our results are not due to a ceiling effect. The compatibility between our psychophysical and computational results suggests that the temporal advantage of the superordinate (resp. basic) level to basic (resp. subordinate) level is mainly due to the computational constraints (the visual system processes higher spatial frequencies more slowly, and categorization in finer levels depends more on these higher spatial frequencies).

Object Categorization in Finer Levels Relies More on Higher Spatial Frequencies and Takes Longer

PubMed Central

Ashtiani, Matin N.; Kheradpisheh, Saeed R.; Masquelier, Timothée; Ganjtabesh, Mohammad

2017-01-01

The human visual system contains a hierarchical sequence of modules that take part in visual perception at different levels of abstraction, i.e., superordinate, basic, and subordinate levels. One important question is to identify the “entry” level at which the visual representation is commenced in the process of object recognition. For a long time, it was believed that the basic level had a temporal advantage over two others. This claim has been challenged recently. Here we used a series of psychophysics experiments, based on a rapid presentation paradigm, as well as two computational models, with bandpass filtered images of five object classes to study the processing order of the categorization levels. In these experiments, we investigated the type of visual information required for categorizing objects in each level by varying the spatial frequency bands of the input image. The results of our psychophysics experiments and computational models are consistent. They indicate that the different spatial frequency information had different effects on object categorization in each level. In the absence of high frequency information, subordinate and basic level categorization are performed less accurately, while the superordinate level is performed well. This means that low frequency information is sufficient for superordinate level, but not for the basic and subordinate levels. These finer levels rely more on high frequency information, which appears to take longer to be processed, leading to longer reaction times. Finally, to avoid the ceiling effect, we evaluated the robustness of the results by adding different amounts of noise to the input images and repeating the experiments. As expected, the categorization accuracy decreased and the reaction time increased significantly, but the trends were the same. This shows that our results are not due to a ceiling effect. The compatibility between our psychophysical and computational results suggests that the temporal advantage of the superordinate (resp. basic) level to basic (resp. subordinate) level is mainly due to the computational constraints (the visual system processes higher spatial frequencies more slowly, and categorization in finer levels depends more on these higher spatial frequencies). PMID:28790954

Effects of bite size and duration of oral processing on retro-nasal aroma release - features contributing to meal termination.

PubMed

Ruijschop, Rianne M A J; Zijlstra, Nicolien; Boelrijk, Alexandra E M; Dijkstra, Annereinou; Burgering, Maurits J M; Graaf, Cees de; Westerterp-Plantenga, Margriet S

2011-01-01

The brain response to a retro-nasally sensed food odour signals the perception of food and it is suggested to be related to satiation. It is hypothesised that consuming food either in multiple small bite sizes or with a longer durations of oral processing may evoke substantial oral processing per gram consumed and an increase in transit time in the oral cavity. This is expected to result in a higher cumulative retro-nasal aroma stimulation, which in turn may lead to increased feelings of satiation and decreased food intake. Using real-time atmospheric pressure chemical ionisation-MS, in vivo retro-nasal aroma release was assessed for twenty-one young, healthy and normal-weight subjects consuming dark chocolate-flavoured custard. Subjects were exposed to both free or fixed bite size (5 and 15 g) and durations of oral processing before swallowing (3 and 9 s) in a cross-over design. For a fixed amount of dark chocolate-flavoured custard, consumption in multiple small bite sizes resulted in a significantly higher cumulative extent of retro-nasal aroma release per gram consumed compared with a smaller amount of large bite sizes. In addition, a longer duration of oral processing tended to result in a higher cumulative extent of retro-nasal aroma release per gram consumed compared with a short duration of oral processing. An interaction effect of bite size and duration of oral processing was not observed. In conclusion, decreasing bite size or increasing duration of oral processing led to a higher cumulative retro-nasal aroma stimulation per gram consumed. Hence, adapting bite size or duration of oral processing indicates that meal termination can be accelerated by increasing the extent of retro-nasal aroma release and, subsequently, the satiation.

The temporal dynamics of masked repetition picture priming effects: manipulations of stimulus-onset asynchrony (SOA) and prime duration

PubMed Central

Eddy, Marianna D.; Holcomb, Phillip J.

2010-01-01

The current study used event-related potentials (ERPs) and masked repetition priming to examine the time-course of picture processing. We manipulated the stimulus-onset asynchrony (110 ms, 230 ms, 350 ms, 470 ms) between repeated and unrepeated prime-target pairs while holding the prime duration constant (50 ms) (Experiment 1) as well as the prime duration (30 ms, 50 ms, 70 ms, 90 ms) (Experiment 2) with a constant SOA of 110 ms in a masked repetition priming paradigm with pictures. The aim of this study was to further elucidate the mechanisms underlying previously observed ERP components in masked priming with pictures. We found both the N/P190 and N400 are modulated by changes in prime duration and SOA, however, it appears that longer prime exposure rather than a longer SOA leads to more in-depth processing as indexed by larger N400 effects. PMID:20403342

[Validation of cold chain during distribution of parenteral nutrition].

PubMed

Tuan, Federico; Perone, Virginia; Verdini, Rocio; Pell, Maria Betina; Traverso, Maria Luz

2015-09-01

this study aims to demonstrate the suitability of the process used to condition the extemporaneous mixtures of parenteral nutrition for distribution, considering the objective of preserving the cold chain during transport until it reaches the patient, necessary to ensure stability, effectiveness and safety of these mixtures. concurrent validation, design and implementation of a protocol for evaluating the process of packaging and distribution of MNPE developed by a pharmaceutical laboratory. Running tests, according to predefined acceptance criteria. It is performed twice, in summer and on routes that require longer transfer time. Evaluation of conservation of temperature by monitoring the internal temperature values of each type of packaging, recorded by data loggers calibrated equipment. the different tests meet the established criteria. The collected data ensure the maintenance of the cold chain for longer than the transfer time to the most distant points. this study establishes the suitability of the processes to maintaining the cold chain for transfer from the laboratory to the patient pharmacist. Whereas the breaking of cold chain can cause changes of compatibility and stability of parenteral nutrition and failures nutritional support, this study contributes to patient safety, one of the relevant dimensions of quality of care the health. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.

Lévy walks with variable waiting time: A ballistic case

NASA Astrophysics Data System (ADS)

Kamińska, A.; Srokowski, T.

2018-06-01

The Lévy walk process for a lower interval of an excursion times distribution (α <1 ) is discussed. The particle rests between the jumps, and the waiting time is position-dependent. Two cases are considered: a rising and diminishing waiting time rate ν (x ) , which require different approximations of the master equation. The process comprises two phases of the motion: particles at rest and in flight. The density distributions for them are derived, as a solution of corresponding fractional equations. For strongly falling ν (x ) , the resting particles density assumes the α -stable form (truncated at fronts), and the process resolves itself to the Lévy flights. The diffusion is enhanced for this case but no longer ballistic, in contrast to the case for the rising ν (x ) . The analytical results are compared with Monte Carlo trajectory simulations. The results qualitatively agree with observed properties of human and animal movements.

Working Memory and the Revision of Syntactic and Discourse Ambiguities

PubMed Central

Evans, William S.; Caplan, David; Ostrowski, Adam; Michaud, Jennifer; Guarino, Anthony; Waters, Gloria

2015-01-01

Two hundred participants, 50 in each of four age ranges (19 – 29; 30 – 49, 50 – 69, 70 – 90) were tested for short term working memory, speed of processing and on-line processing of three types of sentences in which an initially assigned syntactic structure and/or semantic interpretation had to be revised. Self-paced reading times were longer for the segments which signaled the need for revision, and there were interactions of age and sentence type and of speed of processing and sentence type, but not of working memory and sentence type, on reading times for these segments. The results provide evidence that working memory does not support the processes that revise the structure and interpretation of sentences and discourse. PMID:25485458

Letter-sound processing deficits in children with developmental dyslexia: An ERP study.

PubMed

Moll, Kristina; Hasko, Sandra; Groth, Katharina; Bartling, Jürgen; Schulte-Körne, Gerd

2016-04-01

The time course during letter-sound processing was investigated in children with developmental dyslexia (DD) and typically developing (TD) children using electroencephalography. Thirty-eight children with DD and 25 TD children participated in a visual-auditory oddball paradigm. Event-related potentials (ERPs) elicited by standard and deviant stimuli in an early (100-190 ms) and late (560-750 ms) time window were analysed. In the early time window, ERPs elicited by the deviant stimulus were delayed and less left lateralized over fronto-temporal electrodes for children with DD compared to TD children. In the late time window, children with DD showed higher amplitudes extending more over right frontal electrodes. Longer latencies in the early time window and stronger right hemispheric activation in the late time window were associated with slower reading and naming speed. Additionally, stronger right hemispheric activation in the late time window correlated with poorer phonological awareness skills. Deficits in early stages of letter-sound processing influence later more explicit cognitive processes during letter-sound processing. Identifying the neurophysiological correlates of letter-sound processing and their relation to reading related skills provides insight into the degree of automaticity during letter-sound processing beyond behavioural measures of letter-sound-knowledge. Copyright © 2016 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

Nonretinotopic visual processing in the brain.

PubMed

Melcher, David; Morrone, Maria Concetta

2015-01-01

A basic principle in visual neuroscience is the retinotopic organization of neural receptive fields. Here, we review behavioral, neurophysiological, and neuroimaging evidence for nonretinotopic processing of visual stimuli. A number of behavioral studies have shown perception depending on object or external-space coordinate systems, in addition to retinal coordinates. Both single-cell neurophysiology and neuroimaging have provided evidence for the modulation of neural firing by gaze position and processing of visual information based on craniotopic or spatiotopic coordinates. Transient remapping of the spatial and temporal properties of neurons contingent on saccadic eye movements has been demonstrated in visual cortex, as well as frontal and parietal areas involved in saliency/priority maps, and is a good candidate to mediate some of the spatial invariance demonstrated by perception. Recent studies suggest that spatiotopic selectivity depends on a low spatial resolution system of maps that operates over a longer time frame than retinotopic processing and is strongly modulated by high-level cognitive factors such as attention. The interaction of an initial and rapid retinotopic processing stage, tied to new fixations, and a longer lasting but less precise nonretinotopic level of visual representation could underlie the perception of both a detailed and a stable visual world across saccadic eye movements.

Differences between Presentation Methods in Working Memory Procedures: A Matter of Working Memory Consolidation

ERIC Educational Resources Information Center

Ricker, Timothy J.; Cowan, Nelson

2014-01-01

Understanding forgetting from working memory, the memory used in ongoing cognitive processing, is critical to understanding human cognition. In the past decade, a number of conflicting findings have been reported regarding the role of time in forgetting from working memory. This has led to a debate concerning whether longer retention intervals…

Voicing on Virtual and Face to Face Discussion

ERIC Educational Resources Information Center

Yamat, Hamidah

2013-01-01

This paper presents and discusses findings of a study conducted on pre-service teachers' experiences in virtual and face to face discussions. Technology has brought learning nowadays beyond the classroom context or time zone. The learning context and process no longer rely solely on face to face communications in the presence of a teacher.…

48 CFR 970.2204-1-1 - Administrative controls and criteria for application of the Davis-Bacon Act in operational or...

Code of Federal Regulations, 2010 CFR

2010-10-01

... designed for use in a succession of experimental programs over a longer period of time. Examples of loop...) Experimental development of equipment, processes, or devices, including assembly, fitting, installation... for the purpose of conducting a test or experiment. The design may be only conceptual in character...

48 CFR 970.2204-1-1 - Administrative controls and criteria for application of the Davis-Bacon Act in operational or...

Code of Federal Regulations, 2013 CFR

2013-10-01

... designed for use in a succession of experimental programs over a longer period of time. Examples of loop...) Experimental development of equipment, processes, or devices, including assembly, fitting, installation... for the purpose of conducting a test or experiment. The design may be only conceptual in character...

48 CFR 970.2204-1-1 - Administrative controls and criteria for application of the Davis-Bacon Act in operational or...

Code of Federal Regulations, 2012 CFR

2012-10-01

... designed for use in a succession of experimental programs over a longer period of time. Examples of loop...) Experimental development of equipment, processes, or devices, including assembly, fitting, installation... for the purpose of conducting a test or experiment. The design may be only conceptual in character...

48 CFR 970.2204-1-1 - Administrative controls and criteria for application of the Davis-Bacon Act in operational or...

Code of Federal Regulations, 2011 CFR

2011-10-01

... designed for use in a succession of experimental programs over a longer period of time. Examples of loop...) Experimental development of equipment, processes, or devices, including assembly, fitting, installation... for the purpose of conducting a test or experiment. The design may be only conceptual in character...

48 CFR 970.2204-1-1 - Administrative controls and criteria for application of the Davis-Bacon Act in operational or...

Code of Federal Regulations, 2014 CFR

2014-10-01

... designed for use in a succession of experimental programs over a longer period of time. Examples of loop...) Experimental development of equipment, processes, or devices, including assembly, fitting, installation... for the purpose of conducting a test or experiment. The design may be only conceptual in character...

Heavy nuclei as thermal insulation for protoneutron stars

NASA Astrophysics Data System (ADS)

Nakazato, Ken'ichiro; Suzuki, Hideyuki; Togashi, Hajime

2018-03-01

A protoneutron star (PNS) is a newly formed compact object in a core collapse supernova. In this paper, the neutrino emission from the cooling process of a PNS is investigated using two types of nuclear equation of state (EOS). It is found that the neutrino signal is mainly determined by the high-density EOS. The neutrino luminosity and mean energy are higher and the cooling time scale is longer for the softer EOS. Meanwhile, the neutrino mean energy and the cooling time scale are also affected by the low-density EOS because of the difference in the population of heavy nuclei. Heavy nuclei have a large scattering cross section with neutrinos owing to the coherent effects and act as thermal insulation near the surface of a PNS. The neutrino mean energy is higher and the cooling time scale is longer for an EOS with a large symmetry energy at low densities, namely a small density derivative coefficient of the symmetry energy, L .

Recovery of speed of information processing in closed-head-injury patients.

PubMed

Zwaagstra, R; Schmidt, I; Vanier, M

1996-06-01

After severe traumatic brain injury, patients almost invariably demonstrate a slowing of reaction time, reflecting a slowing of central information processing. Methodological problems associated with the traditional method for the analysis of longitudinal data (MANOVA) severely complicate studies on cognitive recovery. It is argued that multilevel models are often better suited for the analysis of improvement over time in clinical settings. Multilevel models take into account individual differences in both overall performance level and recovery. These models enable individual predictions for the recovery of speed of information processing. Recovery is modelled in a group of closed-head-injury patients (N = 24). Recovery was predicted by age and severity of injury, as indicated by coma duration. Over a period up to 44 months post trauma, reaction times were found to decrease faster for patients with longer coma duration.

Space Weathering of Lunar Rocks

NASA Technical Reports Server (NTRS)

Noble, S. K.; Keller, L. P.; Christoffersen, R.; Rahman, Z.

2012-01-01

All materials exposed at the lunar surface undergo space weathering processes. On the Moon, boulders make up only a small percentage of the exposed surface, and areas where such rocks are exposed, like central peaks, are often among the least space weathered regions identified from remote sensing data. Yet space weathered surfaces (patina) are relatively common on returned rock samples, some of which directly sample the surface of larger boulders. Because, as witness plates to lunar space weathering, rocks and boulders experience longer exposure times compared to lunar soil grains, they allow us to develop a deeper perspective on the relative importance of various weathering processes as a function of time.

Aspiration dynamics and the sustainability of resources in the public goods dilemma

NASA Astrophysics Data System (ADS)

Du, Jinming; Wu, Bin; Wang, Long

2016-04-01

How to exploit public non-renewable resources is a public goods dilemma. Individuals can choose to limit the depletion in order to use the resource for a longer time or consume more goods to benefit themselves. When the resource is used up, there is no benefit for the future generations any more, thus the evolutionary process ends. Here we investigate what mechanisms can extend the use of resources in the framework of evolutionary game theory under two updating rules based on imitation and aspiration, respectively. Compared with imitation process, aspiration dynamics may prolong the sustainable time of a public resource.

Plasticity-mediated collapse and recrystallization in hollow copper nanowires: a molecular dynamics simulation.

PubMed

Dutta, Amlan; Raychaudhuri, Arup Kumar; Saha-Dasgupta, Tanusri

2016-01-01

We study the thermal stability of hollow copper nanowires using molecular dynamics simulation. We find that the plasticity-mediated structural evolution leads to transformation of the initial hollow structure to a solid wire. The process involves three distinct stages, namely, collapse, recrystallization and slow recovery. We calculate the time scales associated with different stages of the evolution process. Our findings suggest a plasticity-mediated mechanism of collapse and recrystallization. This contradicts the prevailing notion of diffusion driven transport of vacancies from the interior to outer surface being responsible for collapse, which would involve much longer time scales as compared to the plasticity-based mechanism.

Developmental changes in brain regions involved in phonological and orthographic processing during spoken language processing

PubMed Central

Cone, Nadia E.; Burman, Douglas D.; Bitan, Tali; Bolger, Donald J.; Booth, James R.

2008-01-01

Developmental differences in brain activation of 9- to 15-year-old children were examined during an auditory rhyme decision task to spoken words using functional magnetic resonance imaging (fMRI). As a group, children showed activation in left superior/middle temporal gyri (BA 22, 21), right middle temporal gyrus (BA 21), dorsal (BA 45, pars opercularis) and ventral (BA 46, pars triangularis) aspects of left inferior frontal gyrus, and left fusiform gyrus (BA 37). There was a developmental increase in activation in left middle temporal gyrus (BA 22) across all lexical conditions, suggesting that automatic semantic processing increases with age regardless of task demands. Activation in left dorsal inferior frontal gyrus also showed developmental increases for the conflicting (e.g. PINT-MINT) compared to the non-conflicting (e.g. PRESS-LIST) non-rhyming conditions, indicating that this area becomes increasingly involved in strategic phonological processing in the face of conflicting orthographic and phonological representations. Left inferior temporal/fusiform gyrus (BA 37) activation was also greater for the conflicting (e.g. PINT-MINT) condition, and a developmental increase was found in the positive relationship between individuals' reaction time and activation in left lingual/fusiform gyrus (BA 18) in this condition, indicating an age-related increase in the association between longer reaction times and greater visual-orthographic processing in this conflicting condition. These results suggest that orthographic processing is automatically engaged by children in a task that does not require access to orthographic information for correct performance, especially when orthographic and phonological representations conflict, and especially for longer response latencies in older children. PMID:18413290

Effects of photoperiod on wheat growth, development and yield in CELSS

NASA Astrophysics Data System (ADS)

Yunze, Shen; Shuangsheng, Guo

2014-12-01

A Controlled Ecological Life Support System (CELSS) is a sealed system used in spaceflight in order to provide astronauts with food and O2 by plants. It is of great significance to increase the energy-using efficiency because energy is extremely deficient in the space. Therefore, the objective of this research was to increase the energy-using efficiency of wheat by regulating the photoperiod. Sixteen treatments were set in total: four photoperiods before flowering (PBF) combined with four photoperiods after flowering (PAF) of 12 h, 16 h, 20 h and 24 h. The light source was red-blue LED (90% red+10% blue). As a result, the growth period of wheat was largely extended by shorter PBF, particularly the number of days from tillering to jointing and from jointing to heading. The period from flowering to maturity was extended by shorter PAF. Shorter PBF and longer PAF could increase not only the yield but also the energy-using efficiency of wheat. As for the nutritional quality, longer photoperiod (both PBF and PAF) increased starch concentration as well as decreased protein concentration of seeds. The effects of PBF and PAF were interactional. The lighting strategy with PBF of 12 h and PAF of 24 h was proved to be the optimum photoperiod for wheat cultivation in CELSS. The mechanisms of photoperiod effect contain two aspects. Firstly, photoperiod is a signal for many processes in plant growth, particularly the process of ear differentiation. Shorter PBF promoted the ear differentiation of wheat, increasing the spikelet number, floret number and seed number and thus enhancing the yield. Secondly, longer photoperiod leads to more light energy input and longer time of photosynthesis, so that longer PAF provided more photosynthate and increased seed yield.

The Association of Daytime Maternal Napping and Exercise With Nighttime Sleep in First-Time Mothers Between 3 and 6 Months Postpartum.

PubMed

Lillis, Teresa A; Hamilton, Nancy A; Pressman, Sarah D; Khou, Christina S

2016-10-19

This study investigated the relationship of daytime maternal napping, exercise, caffeine, and alcohol intake to objective and subjective sleep indices. Sixty healthy, nondepressed, first-time mothers between 3 and 6 months postpartum. Seven consecutive days of online behavior diaries, sleep diaries, and wrist actigraphy, collecting Total Sleep Time (TST), Sleep Onset Latency (SOL), and Wake After Sleep Onset (WASO). After controlling for infant age, employment status, infant feeding method, and infant sleeping location, mixed linear models showed that longer average exercise durations were associated with longer average TST, and longer average nap durations were associated with longer average WASO durations. Significant within-person differences in TST and SOL were also observed, such that, on days when participants exercised and napped longer than average, their respective TST and SOL durations that night were longer. Shorter nap durations and longer exercise durations were associated with longer TST, shorter SOL, and reduced WASO. Even small changes in daily exercise and napping behaviors could lead to reliable improvements in postpartum maternal sleep.

Early boost and slow consolidation in motor skill learning.

PubMed

Hotermans, Christophe; Peigneux, Philippe; Maertens de Noordhout, Alain; Moonen, Gustave; Maquet, Pierre

2006-01-01

Motorskill learning is a dynamic process that continues covertly after training has ended and eventually leads to delayed increments in performance. Current theories suggest that this off-line improvement takes time and appears only after several hours. Here we show an early transient and short-lived boost in performance, emerging as early as 5-30 min after training but no longer observed 4 h later. This early boost is predictive of the performance achieved 48 h later, suggesting its functional relevance for memory processes.

Time Manager Software for a Flight Processor

NASA Technical Reports Server (NTRS)

Zoerne, Roger

2012-01-01

Data analysis is a process of inspecting, cleaning, transforming, and modeling data to highlight useful information and suggest conclusions. Accurate timestamps and a timeline of vehicle events are needed to analyze flight data. By moving the timekeeping to the flight processor, there is no longer a need for a redundant time source. If each flight processor is initially synchronized to GPS, they can freewheel and maintain a fairly accurate time throughout the flight with no additional GPS time messages received. How ever, additional GPS time messages will ensure an even greater accuracy. When a timestamp is required, a gettime function is called that immediately reads the time-base register.

Dissociations and interactions between time, numerosity and space processing

PubMed Central

Cappelletti, Marinella; Freeman, Elliot D.; Cipolotti, Lisa

2009-01-01

This study investigated time, numerosity and space processing in a patient (CB) with a right hemisphere lesion. We tested whether these magnitude dimensions share a common magnitude system or whether they are processed by dimension-specific magnitude systems. Five experimental tasks were used: Tasks 1–3 assessed time and numerosity independently and time and numerosity jointly. Tasks 4 and 5 investigated space processing independently and space and numbers jointly. Patient CB was impaired at estimating time and at discriminating between temporal intervals, his errors being underestimations. In contrast, his ability to process numbers and space was normal. A unidirectional interaction between numbers and time was found in both the patient and the control subjects. Strikingly, small numbers were perceived as lasting shorter and large numbers as lasting longer. In contrast, number processing was not affected by time, i.e. short durations did not result in perceiving fewer numbers and long durations in perceiving more numbers. Numbers and space also interacted, with small numbers answered faster when presented on the left side of space, and the reverse for large numbers. Our results demonstrate that time processing can be selectively impaired. This suggests that mechanisms specific for time processing may be partially independent from those involved in processing numbers and space. However, the interaction between numbers and time and between numbers and space also suggests that although independent, there maybe some overlap between time, numbers and space. These data suggest a partly shared mechanism between time, numbers and space which may be involved in magnitude processing or may be recruited to perform cognitive operations on magnitude dimensions. PMID:19501604

Effects of orthographic consistency on eye movement behavior: German and English children and adults process the same words differently.

PubMed

Rau, Anne K; Moll, Kristina; Snowling, Margaret J; Landerl, Karin

2015-02-01

The current study investigated the time course of cross-linguistic differences in word recognition. We recorded eye movements of German and English children and adults while reading closely matched sentences, each including a target word manipulated for length and frequency. Results showed differential word recognition processes for both developing and skilled readers. Children of the two orthographies did not differ in terms of total word processing time, but this equal outcome was achieved quite differently. Whereas German children relied on small-unit processing early in word recognition, English children applied small-unit decoding only upon rereading-possibly when experiencing difficulties in integrating an unfamiliar word into the sentence context. Rather unexpectedly, cross-linguistic differences were also found in adults in that English adults showed longer processing times than German adults for nonwords. Thus, although orthographic consistency does play a major role in reading development, cross-linguistic differences are detectable even in skilled adult readers. Copyright © 2014 Elsevier Inc. All rights reserved.

[Development of an automated processing method to detect coronary motion for coronary magnetic resonance angiography].

PubMed

Asou, Hiroya; Imada, N; Sato, T

2010-06-20

On coronary MR angiography (CMRA), cardiac motions worsen the image quality. To improve the image quality, detection of cardiac especially for individual coronary motion is very important. Usually, scan delay and duration were determined manually by the operator. We developed a new evaluation method to calculate static time of individual coronary artery. At first, coronary cine MRI was taken at the level of about 3 cm below the aortic valve (80 images/R-R). Chronological change of the signals were evaluated with Fourier transformation of each pixel of the images were done. Noise reduction with subtraction process and extraction process were done. To extract higher motion such as coronary arteries, morphological filter process and labeling process were added. Using these imaging processes, individual coronary motion was extracted and individual coronary static time was calculated automatically. We compared the images with ordinary manual method and new automated method in 10 healthy volunteers. Coronary static times were calculated with our method. Calculated coronary static time was shorter than that of ordinary manual method. And scan time became about 10% longer than that of ordinary method. Image qualities were improved in our method. Our automated detection method for coronary static time with chronological Fourier transformation has a potential to improve the image quality of CMRA and easy processing.

Modeling soil moisture memory in savanna ecosystems

NASA Astrophysics Data System (ADS)

Gou, S.; Miller, G. R.

2011-12-01

Antecedent soil conditions create an ecosystem's "memory" of past rainfall events. Such soil moisture memory effects may be observed over a range of timescales, from daily to yearly, and lead to feedbacks between hydrological and ecosystem processes. In this study, we modeled the soil moisture memory effect on savanna ecosystems in California, Arizona, and Africa, using a system dynamics model created to simulate the ecohydrological processes at the plot-scale. The model was carefully calibrated using soil moisture and evapotranspiration data collected at three study sites. The model was then used to simulate scenarios with various initial soil moisture conditions and antecedent precipitation regimes, in order to study the soil moisture memory effects on the evapotranspiration of understory and overstory species. Based on the model results, soil texture and antecedent precipitation regime impact the redistribution of water within soil layers, potentially causing deeper soil layers to influence the ecosystem for a longer time. Of all the study areas modeled, soil moisture memory of California savanna ecosystem site is replenished and dries out most rapidly. Thus soil moisture memory could not maintain the high rate evapotranspiration for more than a few days without incoming rainfall event. On the contrary, soil moisture memory of Arizona savanna ecosystem site lasts the longest time. The plants with different root depths respond to different memory effects; shallow-rooted species mainly respond to the soil moisture memory in the shallow soil. The growing season of grass is largely depended on the soil moisture memory of the top 25cm soil layer. Grass transpiration is sensitive to the antecedent precipitation events within daily to weekly timescale. Deep-rooted plants have different responses since these species can access to the deeper soil moisture memory with longer time duration Soil moisture memory does not have obvious impacts on the phenology of woody plants, as these can maintain transpiration for a longer time even through the top soil layer dries out.

Removal of irrelevant information from working memory: sometimes fast, sometimes slow, and sometimes not at all.

PubMed

Oberauer, Klaus

2018-03-12

To function properly, working memory must be rapidly updated. Updating requires the removal of information no longer relevant. I present six experiments designed to explore the boundary conditions and the time course of removal. A condition in which three out of six memory items can be removed was compared to two baseline conditions in which either three or six items were encoded and maintained in working memory. The time for removal was varied. In experiment 1, in the removal condition, a distinct subset of three words was cued to be irrelevant after encoding all six words. With longer removal time, response times in the removal condition approximated those in the set-size 3 baseline, but accuracies stayed at the set-size 6 level. In experiment 2, in which a random subset of three words was cued as irrelevant, there was no evidence for removal. Experiments 3 and 4 showed that when each item is cued as relevant or irrelevant after its encoding, irrelevant items can be removed rapidly and completely. Experiments 5 and 6 showed that complete removal was no longer possible when words had to be processed before being cued as irrelevant. The pattern of findings can be explained by distinguishing two forms of removal: deactivation removes working-memory contents from the set of competitors for retrieval; unbinding contents from their contexts removes them from working memory entirely, so that they also cease to compete for limited capacity. © 2018 New York Academy of Sciences.

Thermomechanical milling of accessory lithics in volcanic conduits

NASA Astrophysics Data System (ADS)

Campbell, Michelle E.; Russell, James K.; Porritt, Lucy A.

2013-09-01

Accessory lithic clasts recovered from pyroclastic deposits commonly result from the failure of conduit wall rocks, and represent an underutilized resource for constraining conduit processes during explosive volcanic eruptions. The morphological features of lithic clasts provide distinctive 'textural fingerprints' of processes that have reshaped them during transport in the conduit. Here, we present the first study focused on accessory lithic clast morphology and show how the shapes and surfaces of these accessory pyroclasts can inform on conduit processes. We use two main types of accessory lithic clasts from pyroclastic fallout deposits of the 2360 B.P. subplinian eruption of Mount Meager, British Columbia, as a case study: (i) rough and subangular dacite clasts, and (ii) variably rounded and smoothed monzogranite clasts. The quantitative morphological data collected on these lithics include: mass, volume, density, 2-D image analysis of convexity (C), and 3-D laser scans for sphericity (Ψ) and smoothness (S). Shaping and comminution (i.e. milling) of clasts within the conduit are ascribed to three processes: (1) disruptive fragmentation due to high-energy impacts between clasts or between clasts and conduit walls, (2) ash-blasting of clasts suspended within the volcanic flux, and (3) thermal effects. We use a simplified conduit eruption model to predict ash-blasting velocities and lithic residence times as a function of clast size and source depth, thereby constraining the lithic milling processes. The extent of shape and surface modification (i.e. rounding and honing) is directly proportional to clast residence times within the conduit prior to evacuation. We postulate that the shallow-seated dacite clasts remain subangular and rough due to short (<2 min) residence times, whereas monzogranite clasts are much more rounded and smoothed due to deeper source depths and consequently longer residence times (up to ˜1 h). Larger monzogranite clasts are smoother than smaller clasts due to longer residence times and to greater differential velocities within the ash-laden jet. Lastly, our model residence times and mass loss estimates for rounded clasts are used to estimate minimum attrition rates due to volcanic ash-blasting within the conduit (e.g., 12 cm3 s-1 for 25 cm clasts, sourced at 2500 m depth).

Cumulative Significance of Hyporheic Exchange and Biogeochemical Processing in River Networks

NASA Astrophysics Data System (ADS)

Harvey, J. W.; Gomez-Velez, J. D.

2014-12-01

Biogeochemical reactions in rivers that decrease excessive loads of nutrients, metals, organic compounds, etc. are enhanced by hydrologic interactions with microbially and geochemically active sediments of the hyporheic zone. The significance of reactions in individual hyporheic flow paths has been shown to be controlled by the contact time between river water and sediment and the intrinsic reaction rate in the sediment. However, little is known about how the cumulative effects of hyporheic processing in large river basins. We used the river network model NEXSS (Gomez-Velez and Harvey, submitted) to simulate hyporheic exchange through synthetic river networks based on the best available models of network topology, hydraulic geometry and scaling of geomorphic features, grain size, hydraulic conductivity, and intrinsic reaction rates of nutrients and metals in river sediment. The dimensionless reaction significance factor, RSF (Harvey et al., 2013) was used to quantify the cumulative removal fraction of a reactive solute by hyporheic processing. SF scales reaction progress in a single pass through the hyporheic zone with the proportion of stream discharge passing through the hyporheic zone for a specified distance. Reaction progress is optimal where the intrinsic reaction timescale in sediment matches the residence time of hyporheic flow and is less efficient in longer residence time hyporheic flow as a result of the decreasing proportion of river flow that is processed by longer residence time hyporheic flow paths. In contrast, higher fluxes through short residence time hyporheic flow paths may be inefficient because of the repeated surface-subsurface exchanges required to complete the reaction. Using NEXSS we found that reaction efficiency may be high in both small streams and large rivers, although for different reasons. In small streams reaction progress generally is dominated by faster pathways of vertical exchange beneath submerged bedforms. Slower exchange beneath meandering river banks mainly has importance only in large rivers. For solutes entering networks in proportion to water inputs it is the lower order streams that tend to dominate cumulative reaction progress.

Gravitational wave searches with pulsar timing arrays: Cancellation of clock and ephemeris noises

NASA Astrophysics Data System (ADS)

Tinto, Massimo

2018-04-01

We propose a data processing technique to cancel monopole and dipole noise sources (such as clock and ephemeris noises, respectively) in pulsar timing array searches for gravitational radiation. These noises are the dominant sources of correlated timing fluctuations in the lower-part (≈10-9-10-8 Hz ) of the gravitational wave band accessible by pulsar timing experiments. After deriving the expressions that reconstruct these noises from the timing data, we estimate the gravitational wave sensitivity of our proposed processing technique to single-source signals to be at least one order of magnitude higher than that achievable by directly processing the timing data from an equal-size array. Since arrays can generate pairs of clock and ephemeris-free timing combinations that are no longer affected by correlated noises, we implement with them the cross-correlation statistic to search for an isotropic stochastic gravitational wave background. We find the resulting optimal signal-to-noise ratio to be more than one order of magnitude larger than that obtainable by correlating pairs of timing data from arrays of equal size.

Developing high-level change and innovation agents: competencies and challenges for executive leadership.

PubMed

Malloch, Kathy; Melnyk, Bernadette Mazurek

2013-01-01

The work of health care reform and revolution requires leadership competencies that integrate the digital realities of time, space, and media. Leadership skills and behaviors of command, control, and directing from predigital times are no longer effective, given the impacts of the digital changes. Developing leadership competence in evidence-driven processes, facilitation, collaborative teamwork, and instilling a sense of urgency is the work of today's executive leaders. Ten competencies necessary for contemporary executive leadership are presented in this article.

Children Are Not like Older Adults: A Diffusion Model Analysis of Developmental Changes in Speeded Responses

ERIC Educational Resources Information Center

Ratcliff, Roger; Love, Jessica; Thompson, Clarissa A.; Opfer, John E.

2012-01-01

Children (n = 130; M[subscript age] = 8.51-15.68 years) and college-aged adults (n = 72; M[subscript age] = 20.50 years) completed numerosity discrimination and lexical decision tasks. Children produced longer response times (RTs) than adults. R. Ratcliff's (1978) diffusion model, which divides processing into components (e.g., quality of…

Color machine vision in industrial process control: case limestone mine

NASA Astrophysics Data System (ADS)

Paernaenen, Pekka H. T.; Lemstrom, Guy F.; Koskinen, Seppo

1994-11-01

An optical sorter technology has been developed to improve profitability of a mine by using color line scan machine vision technology. The new technology adapted longers the expected life time of the limestone mine and improves its efficiency. Also the project has proved that color line scan technology of today can successfully be applied to industrial use in harsh environments.

Comparing neuronal spike trains with inhomogeneous Poisson distribution: evaluation procedure and experimental application in cases of cyclic activity.

PubMed

Fiore, Lorenzo; Lorenzetti, Walter; Ratti, Giovannino

2005-11-30

A procedure is proposed to compare single-unit spiking activity elicited in repetitive cycles with an inhomogeneous Poisson process (IPP). Each spike sequence in a cycle is discretized and represented as a point process on a circle. The interspike interval probability density predicted for an IPP is computed on the basis of the experimental firing probability density; differences from the experimental interval distribution are assessed. This procedure was applied to spike trains which were repetitively induced by opening-closing movements of the distal article of a lobster leg. As expected, the density of short interspike intervals, less than 20-40 ms in length, was found to lie greatly below the level predicted for an IPP, reflecting the occurrence of the refractory period. Conversely, longer intervals, ranging from 20-40 to 100-120 ms, were markedly more abundant than expected; this provided evidence for a time window of increased tendency to fire again after a spike. Less consistently, a weak depression of spike generation was observed for longer intervals. A Monte Carlo procedure, implemented for comparison, produced quite similar results, but was slightly less precise and more demanding as concerns computation time.

Goal-Directed and Habit-Like Modulations of Stimulus Processing during Reinforcement Learning.

PubMed

Luque, David; Beesley, Tom; Morris, Richard W; Jack, Bradley N; Griffiths, Oren; Whitford, Thomas J; Le Pelley, Mike E

2017-03-15

Recent research has shown that perceptual processing of stimuli previously associated with high-value rewards is automatically prioritized even when rewards are no longer available. It has been hypothesized that such reward-related modulation of stimulus salience is conceptually similar to an "attentional habit." Recording event-related potentials in humans during a reinforcement learning task, we show strong evidence in favor of this hypothesis. Resistance to outcome devaluation (the defining feature of a habit) was shown by the stimulus-locked P1 component, reflecting activity in the extrastriate visual cortex. Analysis at longer latencies revealed a positive component (corresponding to the P3b, from 550-700 ms) sensitive to outcome devaluation. Therefore, distinct spatiotemporal patterns of brain activity were observed corresponding to habitual and goal-directed processes. These results demonstrate that reinforcement learning engages both attentional habits and goal-directed processes in parallel. Consequences for brain and computational models of reinforcement learning are discussed. SIGNIFICANCE STATEMENT The human attentional network adapts to detect stimuli that predict important rewards. A recent hypothesis suggests that the visual cortex automatically prioritizes reward-related stimuli, driven by cached representations of reward value; that is, stimulus-response habits. Alternatively, the neural system may track the current value of the predicted outcome. Our results demonstrate for the first time that visual cortex activity is increased for reward-related stimuli even when the rewarding event is temporarily devalued. In contrast, longer-latency brain activity was specifically sensitive to transient changes in reward value. Therefore, we show that both habit-like attention and goal-directed processes occur in the same learning episode at different latencies. This result has important consequences for computational models of reinforcement learning. Copyright © 2017 the authors 0270-6474/17/373009-09$15.00/0.

Clinical Characteristics and Lesions Responsible for Swallowing Hesitation After Acute Cerebral Infarction.

PubMed

Saito, Tsukasa; Hayashi, Keisuke; Nakazawa, Hajime; Ota, Tetsuo

2016-08-01

Some stroke patients with a unilateral lesion demonstrate acute dysphagia characterized by a markedly prolonged swallowing time, making us think they are reluctant to swallow. In order to clarify the clinical characteristics and causative lesions of delayed swallowing, we conducted a retrospective analysis of 20 right-handed patients without a history of swallowing dysfunction who underwent videofluorography on suspicion of dysphagia after a first ischemic stroke. The oral processing time plus the postfaucial aggregation time required to swallow jelly for patients classified as having delayed swallowing was over 10 s. The time required for swallowing jelly was significantly longer than that without the hesitation (median value, 24.1 vs. 8.9 s, P < 0.001). The oral processing time plus the postfaucial aggregation time required for patients with delayed swallowing to swallow thickened water was largely over 5 s and significantly longer than that of patients without swallowing hesitation (median value, 10.2 vs. 3.3 s, P < 0.001). Swallowing hesitation caused by acute unilateral infarction could be separated into two different patterns. Because four of the five patients with a rippling tongue movement in the swallowing hesitation pattern had a lesion in the left primary motor cortex, which induces some kinds of apraxia, swallowing hesitation with a rippling tongue movement seems to be a representative characteristic of apraxia. The patients with swallowing hesitation with a temporary stasis of the tongue in this study tended to have broad lesions in the frontal lobe, especially in the middle frontal gyrus, which is thought to be involved in higher cognition.

Larger Stimuli Require Longer Processing Time for Perception.

PubMed

Kanai, Ryota; Dalmaijer, Edwin S; Sherman, Maxine T; Kawakita, Genji; Paffen, Chris L E

2017-05-01

The time it takes for a stimulus to reach awareness is often assessed by measuring reaction times (RTs) or by a temporal order judgement (TOJ) task in which perceived timing is compared against a reference stimulus. Dissociations of RT and TOJ have been reported earlier in which increases in stimulus intensity such as luminance intensity results in a decrease of RT, whereas perceived perceptual latency in a TOJ task is affected to a lesser degree. Here, we report that a simple manipulation of stimulus size has stronger effects on perceptual latency measured by TOJ than on motor latency measured by RT tasks. When participants were asked to respond to the appearance of a simple stimulus such as a luminance blob, the perceptual latency measured against a standard reference stimulus was up to 40 ms longer for a larger stimulus. In other words, the smaller stimulus was perceived to occur earlier than the larger one. RT on the other hand was hardly affected by size. The TOJ results were further replicated in a simultaneity judgement task, suggesting that the effects of size are not due to TOJ-specific response biases but more likely reflect an effect on perceived timing.

Slower Perception Followed by Faster Lexical Decision in Longer Words: A Diffusion Model Analysis

PubMed Central

Oganian, Yulia; Froehlich, Eva; Schlickeiser, Ulrike; Hofmann, Markus J.; Heekeren, Hauke R.; Jacobs, Arthur M.

2016-01-01

Effects of stimulus length on reaction times (RTs) in the lexical decision task are the topic of extensive research. While slower RTs are consistently found for longer pseudo-words, a finding coined the word length effect (WLE), some studies found no effects for words, and yet others reported faster RTs for longer words. Moreover, the WLE depends on the orthographic transparency of a language, with larger effects in more transparent orthographies. Here we investigate processes underlying the WLE in lexical decision in German-English bilinguals using a diffusion model (DM) analysis, which we compared to a linear regression approach. In the DM analysis, RT-accuracy distributions are characterized using parameters that reflect latent sub-processes, in particular evidence accumulation and decision-independent perceptual encoding, instead of typical parameters such as mean RT and accuracy. The regression approach showed a decrease in RTs with length for pseudo-words, but no length effect for words. However, DM analysis revealed that the null effect for words resulted from opposing effects of length on perceptual encoding and rate of evidence accumulation. Perceptual encoding times increased with length for words and pseudo-words, whereas the rate of evidence accumulation increased with length for real words but decreased for pseudo-words. A comparison between DM parameters in German and English suggested that orthographic transparency affects perceptual encoding, whereas effects of length on evidence accumulation are likely to reflect contextual information and the increase in available perceptual evidence with length. These opposing effects may account for the inconsistent findings on WLEs. PMID:26779075

Slower Perception Followed by Faster Lexical Decision in Longer Words: A Diffusion Model Analysis.

PubMed

Oganian, Yulia; Froehlich, Eva; Schlickeiser, Ulrike; Hofmann, Markus J; Heekeren, Hauke R; Jacobs, Arthur M

2015-01-01

Effects of stimulus length on reaction times (RTs) in the lexical decision task are the topic of extensive research. While slower RTs are consistently found for longer pseudo-words, a finding coined the word length effect (WLE), some studies found no effects for words, and yet others reported faster RTs for longer words. Moreover, the WLE depends on the orthographic transparency of a language, with larger effects in more transparent orthographies. Here we investigate processes underlying the WLE in lexical decision in German-English bilinguals using a diffusion model (DM) analysis, which we compared to a linear regression approach. In the DM analysis, RT-accuracy distributions are characterized using parameters that reflect latent sub-processes, in particular evidence accumulation and decision-independent perceptual encoding, instead of typical parameters such as mean RT and accuracy. The regression approach showed a decrease in RTs with length for pseudo-words, but no length effect for words. However, DM analysis revealed that the null effect for words resulted from opposing effects of length on perceptual encoding and rate of evidence accumulation. Perceptual encoding times increased with length for words and pseudo-words, whereas the rate of evidence accumulation increased with length for real words but decreased for pseudo-words. A comparison between DM parameters in German and English suggested that orthographic transparency affects perceptual encoding, whereas effects of length on evidence accumulation are likely to reflect contextual information and the increase in available perceptual evidence with length. These opposing effects may account for the inconsistent findings on WLEs.

Alcoholics' selective attention to alcohol stimuli: automated processing?

PubMed

Stormark, K M; Laberg, J C; Nordby, H; Hugdahl, K

2000-01-01

This study investigated alcoholics' selective attention to alcohol words in a version of the Stroop color-naming task. Alcoholic subjects (n = 23) and nonalcoholic control subjects (n = 23) identified the color of Stroop versions of alcohol, emotional, neutral and color words. Manual reaction times (RTs), skin conductance responses (SCRs) and heart rate (HR) were recorded. Alcoholics showed overall longer RTs than controls while both groups were slower in responding to the incongruent color words than to the other words. Alcoholics showed longer RTs to both alcohol (1522.7 milliseconds [ms]) and emotional words (1523.7 ms) than to neutral words (1450.8 ms) which suggests that the content of these words interfered with the ability to attend to the color of the words. There was also a negative correlation (r = -.41) between RT and response accuracy to alcohol words for the alcoholics, reflecting that the longer time the alcoholics used to respond to the color of the alcohol words, the more incorrect their responses were. The alcoholics also showed significantly greater SCRs to alcohol words (0.16 microSiemens) than to any of the other words (ranging from 0.04-0.08 microSiemens), probably reflecting the emotional significance of the alcohol words. Finally, the alcoholics evidenced smaller HR acceleration to alcohol (1.9 delta bpm) compared to neutral (2.8 delta bpm), which could be related to difficulties alcoholics experience in terminating their attention to the alcohol words. These findings indicate that it is difficult for alcoholics to regulate their attention to alcohol stimuli, suggesting that alcoholics' processing of alcohol information is automated.

Direct and real time probe of photoinduced structure transition in colossal magnetoresistive material

DOE PAGES

Li, Junjie; Wang, Xuan; Zhou, Haidong; ...

2016-07-29

Here, we report a direct and real time measurement of photoinduced structure phase transition in single crystal La 0.84Sr 0.16MnO 3 using femtosecond electron diffraction. The melting of orthorhombic lattice ordering under femtosecond optical excitation is found involving two distinct processes with different time scales, an initial fast melting of orthorhombic phase in about 4 ps and a subsequent slower transformation in 90 ps and longer timescales. Furthermore, the fast process is designated as the initial melting of orthorhombic phase induced by the Mn-O bond change that is most likely driven by the quenching of the dynamic Jahn-Teller distortion followingmore » the photo-excitation. We attribute the slow process to the growing of newly formed structure domain from the photo-excited sites to the neighboring non-excited orthorhombic sites.« less

In situ studies of microbial inactivation during high pressure processing

NASA Astrophysics Data System (ADS)

Maldonado, Jose Antonio; Schaffner, Donald W.; Cuitiño, Alberto M.; Karwe, Mukund V.

2016-01-01

High pressure processing (HPP) has been shown to reduce microbial concentration in foods. The mechanisms of microbial inactivation by HPP have been associated with damage to cell membranes. The real-time response of bacteria to HPP was measured to elucidate the mechanisms of inactivation, which can aid in designing more effective processes. Different pressure cycling conditions were used to expose Enterobacter aerogenes cells to HPP. Propidium iodide (PI) was used as a probe, which fluoresces after penetrating cells with damaged membranes and binding with nucleic acids. A HPP vessel with sapphire windows was used for measuring fluorescence in situ. Membrane damage was detected during pressurization and hold time, but not during depressurization. The drop in fluorescence was larger than expected after pressure cycles at higher pressure and longer times. This indicated possible reversible disassociation of ribosomes resulting in additional binding of PI to exposed RNA under pressure and its release after depressurization.

Surgical problems and complex procedures: issues for operative time in robotic totally endoscopic coronary artery bypass grafting.

PubMed

Wiedemann, Dominik; Bonaros, Nikolaos; Schachner, Thomas; Weidinger, Felix; Lehr, Eric J; Vesely, Mark; Bonatti, Johannes

2012-03-01

Robotically assisted totally endoscopic coronary artery bypass grafting (TECAB) is a viable option for closed chest coronary surgery, but it requires learning curves and longer operative times. This study evaluated the effect of extended operation times on the outcome of patients undergoing TECAB. From 2001 to 2009, 325 patients underwent TECAB with the da Vinci telemanipulation system. Correlations between operative times and preoperative, intraoperative, and early postoperative parameters were investigated. Receiver operating characteristic analysis was used to define the threshold of the procedure duration above which intensive care unit stay and ventilation time were prolonged. Demographic data, intraoperative and postoperative parameters, and survival data were compared. Patients with prolonged operative times more often underwent multivessel revascularization (P < .001) and beating-heart TECAB (P =.023). Other preoperative parameters were not associated with longer operative times. Incidences of technical difficulties and conversions (P < .001) were higher among patients with longer operative times. Prolonged intensive care unit stay, mechanical ventilation, hospital stay, and with requirement of blood products were associated with longer operative times. Receiver operating characteristic analysis showed operative times >445 minutes and >478 minutes to predict prolonged (>48 hours) intensive care unit stay and mechanical ventilation, respectively. Patients with procedures >478 minutes had longer hospital stays and higher perioperative morbidity and mortality. Kaplan-Meier analysis revealed decreased survival among patients with operative times >478 minutes. Multivessel revascularization and conversions lead to prolonged operative times in totally endoscopic coronary artery bypass grafting. Longer operative times significantly influence early postoperative and midterm outcomes. Copyright © 2012 The American Association for Thoracic Surgery. Published by Mosby, Inc. All rights reserved.

Transfer of patients with ST-elevation myocardial infarction for primary percutaneous coronary intervention: a province-wide evaluation of "door-in to door-out" delays at the first hospital.

PubMed

Lambert, Laurie J; Brown, Kevin A; Boothroyd, Lucy J; Segal, Eli; Maire, Sébastien; Kouz, Simon; Ross, Dave; Harvey, Richard; Rinfret, Stéphane; Xiao, Yongling; Nasmith, James; Bogaty, Peter

2014-06-24

Interhospital transfer of patients with ST-elevation myocardial infarction (STEMI) for primary percutaneous coronary intervention (PPCI) is associated with longer delays to reperfusion, related in part to turnaround ("door in" to "door out," or DIDO) time at the initial hospital. As part of a systematic, province-wide evaluation of STEMI care, we examined DIDO times and associations with patient, hospital, and process-of-care factors. We performed medical chart review for STEMI patients transferred for PPCI during a 6-month period (October 1, 2008, through March 31, 2009) and linked these data to ambulance service databases. Two core laboratory cardiologists reviewed presenting ECGs to identify left bundle-branch block and, in the absence of left bundle-branch block, definite STEMI (according to both cardiologists) or an ambiguous reading. Median DIDO time was 51 minutes (25th to 75th percentile: 35-82 minutes); 14.1% of the 988 patients had a timely DIDO interval (≤30 minutes as recommended by guidelines). The data-to-decision delay was the major contributor to DIDO time. Female sex, more comorbidities, longer symptom duration, arrival by means other than ambulance, arrival at a hospital not exclusively transferring for PPCI, arrival at a center with a low STEMI volume, and an ambiguous ECG were independently associated with longer DIDO time. When turnaround was timely, 70% of patients received timely PPCI (door-to-device time ≤90 minutes) versus 14% if turnaround was not timely (P<0.0001). Benchmark DIDO times for STEMI patients transferred for PPCI were rarely achieved. Interventions aimed at facilitating the transfer decision, particularly in cases of ECGs that are difficult to interpret, are likely to have the best impact on reducing delay to reperfusion. © 2014 American Heart Association, Inc.

Planning and production of grammatical and lexical verbs in multi-word messages.

PubMed

Michel Lange, Violaine; Messerschmidt, Maria; Harder, Peter; Siebner, Hartwig Roman; Boye, Kasper

2017-01-01

Grammatical words represent the part of grammar that can be most directly contrasted with the lexicon. Aphasiological studies, linguistic theories and psycholinguistic studies suggest that their processing is operated at different stages in speech production. Models of sentence production propose that at the formulation stage, lexical words are processed at the functional level while grammatical words are processed at a later positional level. In this study we consider proposals made by linguistic theories and psycholinguistic models to derive two predictions for the processing of grammatical words compared to lexical words. First, based on the assumption that grammatical words are less crucial for communication and therefore paid less attention to, it is predicted that they show shorter articulation times and/or higher error rates than lexical words. Second, based on the assumption that grammatical words differ from lexical words in being dependent on a lexical host, it is hypothesized that the retrieval of a grammatical word has to be put on hold until its lexical host is available, and it is predicted that this is reflected in longer reaction times (RTs) for grammatical compared to lexical words. We investigated these predictions by comparing fully homonymous sentences with only a difference in verb status (grammatical vs. lexical) elicited by a specific context. We measured RTs, duration and accuracy rate. No difference in duration was observed. Longer RTs and a lower accuracy rate for grammatical words were reported, successfully reflecting grammatical word properties as defined by linguistic theories and psycholinguistic models. Importantly, this study provides insight into the span of encoding and grammatical encoding processes in speech production.

Planning and production of grammatical and lexical verbs in multi-word messages

PubMed Central

Messerschmidt, Maria; Harder, Peter; Siebner, Hartwig Roman; Boye, Kasper

2017-01-01

Grammatical words represent the part of grammar that can be most directly contrasted with the lexicon. Aphasiological studies, linguistic theories and psycholinguistic studies suggest that their processing is operated at different stages in speech production. Models of sentence production propose that at the formulation stage, lexical words are processed at the functional level while grammatical words are processed at a later positional level. In this study we consider proposals made by linguistic theories and psycholinguistic models to derive two predictions for the processing of grammatical words compared to lexical words. First, based on the assumption that grammatical words are less crucial for communication and therefore paid less attention to, it is predicted that they show shorter articulation times and/or higher error rates than lexical words. Second, based on the assumption that grammatical words differ from lexical words in being dependent on a lexical host, it is hypothesized that the retrieval of a grammatical word has to be put on hold until its lexical host is available, and it is predicted that this is reflected in longer reaction times (RTs) for grammatical compared to lexical words. We investigated these predictions by comparing fully homonymous sentences with only a difference in verb status (grammatical vs. lexical) elicited by a specific context. We measured RTs, duration and accuracy rate. No difference in duration was observed. Longer RTs and a lower accuracy rate for grammatical words were reported, successfully reflecting grammatical word properties as defined by linguistic theories and psycholinguistic models. Importantly, this study provides insight into the span of encoding and grammatical encoding processes in speech production. PMID:29091940

Estimation of surface heat and moisture fluxes over a prairie grassland. II - Two-dimensional time filtering and site variability

NASA Technical Reports Server (NTRS)

Crosson, William L.; Smith, Eric A.

1992-01-01

The behavior of in situ measurements of surface fluxes obtained during FIFE 1987 is examined by using correlative and spectral techniques in order to assess the significance of fluctuations on various time scales, from subdiurnal up to synoptic, intraseasonal, and annual scales. The objectives of this analysis are: (1) to determine which temporal scales have a significant impact on areal averaged fluxes and (2) to design a procedure for filtering an extended flux time series that preserves the basic diurnal features and longer time scales while removing high frequency noise that cannot be attributed to site-induced variation. These objectives are accomplished through the use of a two-dimensional cross-time Fourier transform, which serves to separate processes inherently related to diurnal and subdiurnal variability from those which impact flux variations on the longer time scales. A filtering procedure is desirable before the measurements are utilized as input with an experimental biosphere model, to insure that model based intercomparisons at multiple sites are uncontaminated by input variance not related to true site behavior. Analysis of the spectral decomposition indicates that subdiurnal time scales having periods shorter than 6 hours have little site-to-site consistency and therefore little impact on areal integrated fluxes.

Meterwavelength Single-pulse Polarimetric Emission Survey. III. The Phenomenon of Nulling in Pulsars

DOE Office of Scientific and Technical Information (OSTI.GOV)

Basu, Rahul; Mitra, Dipanjan; Melikidze, George I., E-mail: rahulbasu.astro@gmail.com

A detailed analysis of nulling was conducted for the pulsars studied in the Meterwavelength Single-pulse Polarimetric Emission Survey. We characterized nulling in 36 pulsars including 17 pulsars where the phenomenon was reported for the first time. The most dominant nulls lasted for a short duration, less than five periods. Longer duration nulls extending to hundreds of periods were also seen in some cases. A careful analysis showed the presence of periodicities in the transition from the null to the burst states in 11 pulsars. In our earlier work, fluctuation spectrum analysis showed multiple periodicities in 6 of these 11 pulsars.more » We demonstrate that the longer periodicity in each case was associated with nulling. The shorter periodicities usually originate from subpulse drifting. The nulling periodicities were more aligned with the periodic amplitude modulation, indicating a possible common origin for both. The most prevalent nulls last for a single period and can be potentially explained using random variations affecting the plasma processes in the pulsar magnetosphere. On the other hand, longer-duration nulls require changes in the pair-production processes, which need an external triggering mechanism for the changes. The presence of periodic nulling puts an added constraint on the triggering mechanism, which also needs to be periodic.« less

Quality Service Analysis and Improvement of Pharmacy Unit of XYZ Hospital Using Value Stream Analysis Methodology

NASA Astrophysics Data System (ADS)

Jonny; Nasution, Januar

2013-06-01

Value stream mapping is a tool which is needed to let the business leader of XYZ Hospital to see what is actually happening in its business process that have caused longer lead time for self-produced medicines in its pharmacy unit. This problem has triggered many complaints filed by patients. After deploying this tool, the team has come up with the fact that in processing the medicine, pharmacy unit does not have any storage and capsule packing tool and this condition has caused many wasting times in its process. Therefore, the team has proposed to the business leader to procure the required tools in order to shorten its process. This research has resulted in shortened lead time from 45 minutes to 30 minutes as required by the government through Indonesian health ministry with increased %VA (valued added activity) or Process Cycle Efficiency (PCE) from 66% to 68% (considered lean because it is upper than required 30%). This result has proved that the process effectiveness has been increase by the improvement.

Antigen Masking During Fixation and Embedding, Dissected

PubMed Central

Scalia, Carla Rossana; Boi, Giovanna; Bolognesi, Maddalena Maria; Riva, Lorella; Manzoni, Marco; DeSmedt, Linde; Bosisio, Francesca Maria; Ronchi, Susanna; Leone, Biagio Eugenio; Cattoretti, Giorgio

2016-01-01

Antigen masking in routinely processed tissue is a poorly understood process caused by multiple factors. We sought to dissect the effect on antigenicity of each step of processing by using frozen sections as proxies of the whole tissue. An equivalent extent of antigen masking occurs across variable fixation times at room temperature. Most antigens benefit from longer fixation times (>24 hr) for optimal detection after antigen retrieval (AR; for example, Ki-67, bcl-2, ER). The transfer to a graded alcohol series results in an enhanced staining effect, reproduced by treating the sections with detergents, possibly because of a better access of the polymeric immunohistochemical detection system to tissue structures. A second round of masking occurs upon entering the clearing agent, mostly at the paraffin embedding step. This may depend on the non-freezable water removal. AR fully reverses the masking due both to the fixation time and the paraffin embedding. AR itself destroys some epitopes which do not survive routine processing. Processed frozen sections are a tool to investigate fixation and processing requirements for antigens in routine specimens. PMID:27798289

Power Ultrasound to Process Dairy Products

NASA Astrophysics Data System (ADS)

Bermúdez-Aguirre, Daniela; Barbosa-Cánovas, Gustavo V.

Conventional methods of pasteurizing milk involve the use of heat regardless of treatment (batch, high temperature short time - HTST or ultra high temperature - UHT sterilization), and the quality of the milk is affected because of the use of high temperatures. Consequences of thermal treatment are a decrease in nutritional properties through the destruction of vitamins or denaturation of proteins, and sometimes the flavor of milk is undesirably changed. These changes are produced at the same time that the goal of the pasteurization process is achieved, which is to have a microbiological safe product, free of pathogenic bacteria, and to reduce the load of deteriorative microorganisms and enzymes, resulting in a product with a longer storage life.

Plasticity-mediated collapse and recrystallization in hollow copper nanowires: a molecular dynamics simulation

PubMed Central

Raychaudhuri, Arup Kumar; Saha-Dasgupta, Tanusri

2016-01-01

Summary We study the thermal stability of hollow copper nanowires using molecular dynamics simulation. We find that the plasticity-mediated structural evolution leads to transformation of the initial hollow structure to a solid wire. The process involves three distinct stages, namely, collapse, recrystallization and slow recovery. We calculate the time scales associated with different stages of the evolution process. Our findings suggest a plasticity-mediated mechanism of collapse and recrystallization. This contradicts the prevailing notion of diffusion driven transport of vacancies from the interior to outer surface being responsible for collapse, which would involve much longer time scales as compared to the plasticity-based mechanism. PMID:26977380

Investigating tunneling process of atom exposed in circularly polarized strong-laser field

NASA Astrophysics Data System (ADS)

Yuan, MingHu; Xin, PeiPei; Chu, TianShu; Liu, HongPing

2017-03-01

We propose a method for studying the tunneling process by analyzing the instantaneous ionization rate of a circularly polarized laser. A numerical calculation shows that, for an atom exposed to a long laser pulse, if its initial electronic state wave function is non-spherical symmetric, the delayed phase shift of the ionization rate vs the laser cycle period in real time in the region close to the peak intensity of the laser pulse can be used to probe the tunneling time. In this region, an obvious time delay phase shift of more than 190 attoseconds is observed. Further study shows that the atom has a longer tunneling time in the ionization under a shorter wavelength laser pulse. In our method, a Wigner rotation technique is employed to numerically solve the time-dependent Schrödinger equation of a single-active electron in a three-dimensional spherical coordinate system.

Reading Function and Content Words in Subtitled Videos

PubMed Central

Szarkowska, Agnieszka; Łogińska, Maria

2016-01-01

In this study, we examined how function and content words are read in intra- and interlingual subtitles. We monitored eye movements of a group of 39 deaf, 27 hard of hearing, and 56 hearing Polish participants while they viewed English and Polish videos with Polish subtitles. We found that function words and short content words received less visual attention than longer content words, which was reflected in shorter dwell time, lower number of fixations, shorter first fixation duration, and lower subject hit count. Deaf participants dwelled significantly longer on function words than other participants, which may be an indication of their difficulty in processing this type of words. The findings are discussed in the context of classical reading research and applied research on subtitling. PMID:26681268

Leaf Phenological Characters of Main Tree Species in Urban Forest of Shenyang

PubMed Central

Xu, Sheng; Xu, Wenduo; Chen, Wei; He, Xingyuan; Huang, Yanqing; Wen, Hua

2014-01-01

Background Plant leaves, as the main photosynthetic organs and the high energy converters among primary producers in terrestrial ecosystems, have attracted significant research attention. Leaf lifespan is an adaptive characteristic formed by plants to obtain the maximum carbon in the long-term adaption process. It determines important functional and structural characteristics exhibited in the environmental adaptation of plants. However, the leaf lifespan and leaf characteristics of urban forests were not studied up to now. Methods By using statistic, linear regression methods and correlation analysis, leaf phenological characters of main tree species in urban forest of Shenyang were observed for five years to obtain the leafing phenology (including leafing start time, end time, and duration), defoliating phenology (including defoliation start time, end time, and duration), and the leaf lifespan of the main tree species. Moreover, the relationships between temperature and leafing phenology, defoliating phenology, and leaf lifespan were analyzed. Findings The timing of leafing differed greatly among species. The early leafing species would have relatively early end of leafing; the longer it took to the end of leafing would have a later time of completed leafing. The timing of defoliation among different species varied significantly, the early defoliation species would have relatively longer duration of defoliation. If the mean temperature rise for 1°C in spring, the time of leafing would experience 5 days earlier in spring. If the mean temperature decline for 1°C, the time of defoliation would experience 3 days delay in autumn. Interpretation There is significant correlation between leaf longevity and the time of leafing and defoliation. According to correlation analysis and regression analysis, there is significant correlation between temperature and leafing and defoliation phenology. Early leafing species would have a longer life span and consequently have advantage on carbon accumulation compared with later defoliation species. PMID:24963625

[The effect of a new antiparkinson agent, Selegilin, on psychomotor performance in humans].

PubMed

Müller-Limmroth, W

1985-01-01

A combination of tests consisting of a compensation task with differential value indication, a tachystoscopic arrangement with verbal identification of characteristic features and an arrangement for a visually induced motor reaction was carried out on 12 healthy volunteers aged from 20-30 to determine psychomotor efficiency under the influence of the new antiparkinson drug selegiline (Eldepryl). The results were compared with the effects of the psychostimulant fenetylline and the depressant-antihistamine chlorphenoxamine, and with a placebo. While fenetylline and chlorphenoxamine produced the anticipated effects with regard to an improvement or deterioration in performance in all parameters, selegiline resulted in a slightly longer motor reaction time and an increase in control errors, and in a significantly longer mental processing time. In comparison with the placebo, selegiline increased the motor reaction time by 0.8 +/- 1.95% and mental processing time by 4.1 +/- 1.7%. This depressant effect of selegiline, however, only attained 1/8 and 2/3, resp., of the sedative effect of the normal dose of the antihistamine chlorophenoxamine. Under the influence of chlorphenoxamine, performance becomes less regular and under fenetylline more regular. Selegiline does not differ significantly from the placebo. In spite of selegiline metabolites 1-metamphetamine and 1-amphetamine, which act as mild stimulants, the slightly depressant effect of selegiline detected can be explained by the increased effect of dopamine inhibitory neurons, particularly in the inhibitory system of the formatio reticularis and the cortex frontalis as a result of a concentration of dopamine.

Recrystallization-Induced Surface Cracks of Carbon Ions Irradiated 6H-SiC after Annealing.

PubMed

Ye, Chao; Ran, Guang; Zhou, Wei; Shen, Qiang; Feng, Qijie; Lin, Jianxin

2017-10-25

Single crystal 6H-SiC wafers with 4° off-axis [0001] orientation were irradiated with carbon ions and then annealed at 900 °C for different time periods. The microstructure and surface morphology of these samples were investigated by grazing incidence X-ray diffraction (GIXRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). Ion irradiation induced SiC amorphization, but the surface was smooth and did not have special structures. During the annealing process, the amorphous SiC was recrystallized to form columnar crystals that had a large amount of twin structures. The longer the annealing time was, the greater the amount of recrystallized SiC would be. The recrystallization volume fraction was accorded with the law of the Johnson-Mehl-Avrami equation. The surface morphology consisted of tiny pieces with an average width of approximately 30 nm in the annealed SiC. The volume shrinkage of irradiated SiC layer and the anisotropy of newly born crystals during annealing process produced internal stress and then induced not only a large number of dislocation walls in the non-irradiated layer but also the initiation and propagation of the cracks. The direction of dislocation walls was perpendicular to the growth direction of the columnar crystal. The longer the annealing time was, the larger the length and width of the formed crack would be. A quantitative model of the crack growth was provided to calculate the length and width of the cracks at a given annealing time.

Intact figure-ground segmentation in schizophrenia.

PubMed

Herzog, Michael H; Kopmann, Sabine; Brand, Andreas

2004-11-30

As revealed by backward masking studies, schizophrenic patients show strong impairments of early visual processing. However, the underlying temporal mechanisms are not yet well understood. To shed light on the exact timing of these deficits, we employed a paradigm in which two masks follow each other. We investigated 16 medicated schizophrenic patients and a matched group of 14 controls with a new backward masking technique, shine-through. In accordance with other masking studies, schizophrenic patients require a dramatically longer processing time to reach a predefined performance level compared with healthy subjects. However, patients are surprisingly sensitive to subtle differences in the timing of the two masks, revealing good temporal resolution. This good temporal resolution indicates intact and fast perceptual grouping and figure-ground segmentation in spite of high susceptibility to masking procedures in schizophrenia.

Facilitating Analysis of Multiple Partial Data Streams

NASA Technical Reports Server (NTRS)

Maimone, Mark W.; Liebersbach, Robert R.

2008-01-01

Robotic Operations Automation: Mechanisms, Imaging, Navigation report Generation (ROAMING) is a set of computer programs that facilitates and accelerates both tactical and strategic analysis of time-sampled data especially the disparate and often incomplete streams of Mars Explorer Rover (MER) telemetry data described in the immediately preceding article. As used here, tactical refers to the activities over a relatively short time (one Martian day in the original MER application) and strategic refers to a longer time (the entire multi-year MER missions in the original application). Prior to installation, ROAMING must be configured with the types of data of interest, and parsers must be modified to understand the format of the input data (many example parsers are provided, including for general CSV files). Thereafter, new data from multiple disparate sources are automatically resampled into a single common annotated spreadsheet stored in a readable space-separated format, and these data can be processed or plotted at any time scale. Such processing or plotting makes it possible to study not only the details of a particular activity spanning only a few seconds, but also longer-term trends. ROAMING makes it possible to generate mission-wide plots of multiple engineering quantities [e.g., vehicle tilt as in Figure 1(a), motor current, numbers of images] that, heretofore could be found only in thousands of separate files. ROAMING also supports automatic annotation of both images and graphs. In the MER application, labels given to terrain features by rover scientists and engineers are automatically plotted in all received images based on their associated camera models (see Figure 2), times measured in seconds are mapped to Mars local time, and command names or arbitrary time-labeled events can be used to label engineering plots, as in Figure 1(b).

[Improving the CMP appointment waiting time for children and adolescents].

PubMed

Cani, Pascale

2014-01-01

The increasing activity of mental health centres for children and adolescents and longer waiting times in obtaining a first appointment have led an area of child psychiatry to question the organisation of new consultation applications. Two CMP in the sector had a waiting period of over 40 days for half of the patients. Two improvement actions were implemented:the implementation of organisation and reception nurses and the development of a new applications management process. The evaluation after one year showed a decrease of half of the appointment waiting time without changing the non showed up rate.

Private Industry Support to Defense Needs.

DTIC Science & Technology

1982-04-19

especially private industry, must fully understand that defense procurement is changing drastically and it will no longer be looking for all its...products on the leading edge of technology. The price in time and money dictates this changed procure - ment strategy immediately. Private industry would...A process to stablize procurements and breakdown the barriers that are stopping new firms from entering into defense business; private industry

Methodology Investigation of AI Test Officer Support Tool II

DTIC Science & Technology

1989-10-01

request. B-1 This page intentionally blank B-2 APPENDIX C. ACRONYM AND AB9EVIATIONS ADP ............ Autmated Data Processing AI...longer needed. Do not return it to the originator. DISCLAIMER Information and data contained in this document are based on input available at the time...infrastructure, with subsequent incorporation of common requirements into a supporting structure (i.e., data bases, networks, geographic information

Predictors for cecal insertion time: the impact of abdominal visceral fat measured by computed tomography.

PubMed

Nagata, Naoyoshi; Sakamoto, Kayo; Arai, Tomohiro; Niikura, Ryota; Shimbo, Takuro; Shinozaki, Masafumi; Noda, Mitsuhiko; Uemura, Naomi

2014-10-01

Several factors affect the risk for longer cecal insertion time. The aim of this study was to identify the predictors of longer insertion time and to evaluate the effect of visceral fat measured by CT. This is a retrospective observational study. Outpatients for colorectal cancer screening who underwent colonoscopies and CT were enrolled. Computed tomography was performed in individuals who requested cancer screening and in those with GI bleeding. Information on obesity indices (BMI, visceral adipose tissue, and subcutaneous adipose tissue area), constipation score, history of abdominal surgery, poor preparation, fellow involvement, diverticulosis, patient discomfort, and the amount of sedation used was collected. The cecal insertion rate was 95.2% (899/944), and 899 patients were analyzed. Multiple regression analysis showed that female sex, lower BMI, lower visceral adipose tissue area, lower subcutaneous adipose tissue area, higher constipation score, history of surgery, poor bowel preparation, and fellow involvement were independently associated with longer insertion time. When obesity indices were considered simultaneously, smaller subcutaneous adipose tissue area (p = 0.038), but not lower BMI (p = 0.802) or smaller visceral adipose tissue area (p = 0.856), was associated with longer insertion time; the other aforementioned factors remained associated with longer insertion time. In the subanalysis of normal-weight patients (BMI <25 kg/m), a smaller subcutaneous adipose tissue area (p = 0.002), but not a lower BMI (p = 0.782), was independently associated with a longer insertion time. Longer insertion time had a positive correlation with a higher patient discomfort score (ρ = 0.51, p < 0.001) and a greater amount of midazolam use (ρ = 0.32, p < 0.001). This single-center retrospective study includes a potential selection bias. In addition to BMI and intra-abdominal fat, female sex, constipation, history of abdominal surgery, poor preparation, and fellow involvement were predictors of longer cecal insertion time. Among the obesity indices, high subcutaneous fat accumulation was the best predictive factor for easier passage of the colonoscope, even when body weight was normal.

From self to social cognition: Theory of Mind mechanisms and their relation to Executive Functioning.

PubMed

Bradford, Elisabeth E F; Jentzsch, Ines; Gomez, Juan-Carlos

2015-05-01

'Theory of Mind' refers to the ability to attribute mental states to oneself and other people (Premack & Woodruff, 1978). This study examined the extent to which 'Self' and 'Other' belief-attribution processes within the Theory of Mind (ToM) mechanism could be distinguished behaviourally, and whether these separable components differentially related to Executive Functioning (EF) abilities. A computerized false-belief task, utilizing a matched-design to allow direct comparison of self-oriented vs. other-oriented belief-attribution, was used to assess ToM, and a face-image Stroop task was employed to assess EF, within a population of typically-developed adults. Results revealed significantly longer reaction times when attributing beliefs to other people as opposed to recognizing and attributing beliefs to oneself. Intriguingly, results revealed that 'perspective-shift' requirements (i.e. changing from adoption of the 'self' perspective to the perspective of the 'other', or vice versa) across false-belief trials influenced reaction times. Reaction times were significantly longer when the perspective shift was from self-to-other than from other-to-self. It is suggested that the 'self' forms the stem of understanding the 'other', and is therefore processed regardless of ultimate task demands; in contrast, the 'other' perspective is only processed when explicitly required. We conclude that adopting another person's perspective, even when their belief state is matched to one's own, requires more cognitive effort than recalling and reflecting on self-oriented belief-states. Copyright © 2015 The Authors. Published by Elsevier B.V. All rights reserved.

Selective Impairment of Spatial Cognition Caused by Autoantibodies to the N-Methyl-d-Aspartate Receptor

PubMed Central

Chang, Eric H.; Volpe, Bruce T.; Mackay, Meggan; Aranow, Cynthia; Watson, Philip; Kowal, Czeslawa; Storbeck, Justin; Mattis, Paul; Berlin, RoseAnn; Chen, Huiyi; Mader, Simone; Huerta, Tomás S.; Huerta, Patricio T.; Diamond, Betty

2015-01-01

Patients with systemic lupus erythematosus (SLE) experience cognitive abnormalities in multiple domains including processing speed, executive function, and memory. Here we show that SLE patients carrying antibodies that bind DNA and the GluN2A and GluN2B subunits of the N-methyl-d-aspartate receptor (NMDAR), termed DNRAbs, displayed a selective impairment in spatial recall. Neural recordings in a mouse model of SLE, in which circulating DNRAbs penetrate the hippocampus, revealed that CA1 place cells exhibited a significant expansion in place field size. Structural analysis showed that hippocampal pyramidal cells had substantial reductions in their dendritic processes and spines. Strikingly, these abnormalities became evident at a time when DNRAbs were no longer detectable in the hippocampus. These results suggest that antibody-mediated neurocognitive impairments may be highly specific, and that spatial cognition may be particularly vulnerable to DNRAb-mediated structural and functional injury to hippocampal cells that evolves after the triggering insult is no longer present. PMID:26286205

The temporal dynamics of masked repetition picture priming effects: manipulations of stimulus-onset asynchrony (SOA) and prime duration.

PubMed

Eddy, Marianna D; Holcomb, Phillip J

2010-06-22

The current study used event-related potentials (ERPs) and masked repetition priming to examine the time-course of picture processing. We manipulated the stimulus-onset asynchrony (110 ms, 230 ms, 350 ms, and 470 ms) between repeated and unrepeated prime-target pairs while holding the prime duration constant (50 ms) (Experiment 1) as well as the prime durations (30 ms, 50 ms, 70 ms, and 90 ms) (Experiment 2) with a constant SOA of 110 ms in a masked repetition priming paradigm with pictures. The aim of this study was to further elucidate the mechanisms underlying previously observed ERP components in masked priming with pictures. We found that both the N/P190 and N400 are modulated by changes in prime duration and SOA, however, it appears that longer prime exposure rather than a longer SOA leads to more in-depth processing as indexed by larger N400 effects. (c) 2010 Elsevier B.V. All rights reserved.

Effect of posttraumatic stress on study time in a task measuring four component processes underlying text-level reading.

PubMed

Sullivan, Michael P; Griffiths, Gina G; Moore Sohlberg, Mckay

2014-10-01

To investigate the effect of combat-related posttraumatic stress disorder (PTSD) on 4 components underlying text-level reading comprehension. A group of 17 veterans with PTSD and 17 matched control participants took part. An experimental task required participants to read and study 3-sentence paragraphs describing semantic features associated with real and unreal objects. Each paragraph was followed by true-false statements that assessed knowledge access, text memory, inference, and integration. The results revealed that the PTSD group took significantly longer than the control group to study the paragraphs. Although there was no group difference in test statement accuracy, the PTSD group also took significantly longer to respond to the test statements. Overall, the results provide evidence for the control theory of attention but suggest that more direct measures of task-irrelevant processing during text-level reading are needed. More important, the results begin to lay a foundation for developing not only diagnostic but also intervention strategies.

An application of digital image processing techniques to the characterization of liquid petroleum gas (LPG) spray

NASA Astrophysics Data System (ADS)

Qi, Y. L.; Xu, B. Y.; Cai, S. L.

2006-12-01

To control fuel injection, optimize combustion and reduce emissions for LPG (liquefied petroleum gas) engines, it is necessary and important to understand the characteristics of LPG sprays. The present work investigates the geometry of LPG sprays, including spray tip penetration, spray angle, projected spray area and spray volume, by using schlieren photography and digital image processing techniques. Two types of single nozzle injectors were studied, with the same nozzle diameter, but one with and one without a double-hole flow-split head. A code developed to analyse the results directly from the digitized images is shown to be more accurate and efficient than manual measurement and analysis. Test results show that a higher injection pressure produces a longer spray tip penetration, a larger projected spray area and spray volume, but a smaller spray cone angle. The injector with the double-hole split-head nozzle produces better atomization and shorter tip penetration at medium and late injection times, but longer tip penetration in the early stage.

24-Hour Relativistic Bit Commitment.

PubMed

Verbanis, Ephanielle; Martin, Anthony; Houlmann, Raphaël; Boso, Gianluca; Bussières, Félix; Zbinden, Hugo

2016-09-30

Bit commitment is a fundamental cryptographic primitive in which a party wishes to commit a secret bit to another party. Perfect security between mistrustful parties is unfortunately impossible to achieve through the asynchronous exchange of classical and quantum messages. Perfect security can nonetheless be achieved if each party splits into two agents exchanging classical information at times and locations satisfying strict relativistic constraints. A relativistic multiround protocol to achieve this was previously proposed and used to implement a 2-millisecond commitment time. Much longer durations were initially thought to be insecure, but recent theoretical progress showed that this is not so. In this Letter, we report on the implementation of a 24-hour bit commitment solely based on timed high-speed optical communication and fast data processing, with all agents located within the city of Geneva. This duration is more than 6 orders of magnitude longer than before, and we argue that it could be extended to one year and allow much more flexibility on the locations of the agents. Our implementation offers a practical and viable solution for use in applications such as digital signatures, secure voting and honesty-preserving auctions.

Bypassing the Kohn-Sham equations with machine learning.

PubMed

Brockherde, Felix; Vogt, Leslie; Li, Li; Tuckerman, Mark E; Burke, Kieron; Müller, Klaus-Robert

2017-10-11

Last year, at least 30,000 scientific papers used the Kohn-Sham scheme of density functional theory to solve electronic structure problems in a wide variety of scientific fields. Machine learning holds the promise of learning the energy functional via examples, bypassing the need to solve the Kohn-Sham equations. This should yield substantial savings in computer time, allowing larger systems and/or longer time-scales to be tackled, but attempts to machine-learn this functional have been limited by the need to find its derivative. The present work overcomes this difficulty by directly learning the density-potential and energy-density maps for test systems and various molecules. We perform the first molecular dynamics simulation with a machine-learned density functional on malonaldehyde and are able to capture the intramolecular proton transfer process. Learning density models now allows the construction of accurate density functionals for realistic molecular systems.Machine learning allows electronic structure calculations to access larger system sizes and, in dynamical simulations, longer time scales. Here, the authors perform such a simulation using a machine-learned density functional that avoids direct solution of the Kohn-Sham equations.

Comparison of the Operative Outcomes and Learning Curves between Laparoscopic and Robotic Gastrectomy for Gastric Cancer

PubMed Central

Huang, Kuo-Hung; Lan, Yuan-Tzu; Fang, Wen-Liang; Chen, Jen-Hao; Lo, Su-Shun; Li, Anna Fen-Yau; Chiou, Shih-Hwa; Wu, Chew-Wun; Shyr, Yi-Ming

2014-01-01

Background Minimally invasive surgery, including laparoscopic and robotic gastrectomy, has become more popular in the treatment of gastric cancer. However, few studies have compared the learning curves between laparoscopic and robotic gastrectomy for gastric cancer. Methods Data were prospectively collected between July 2008 and Aug 2014. A total of 145 patients underwent minimally invasive gastrectomy for gastric cancer by a single surgeon, including 73 laparoscopic and 72 robotic gastrectomies. The clinicopathologic characteristics, operative outcomes and learning curves were compared between the two groups. Results Compared with the laparoscopic group, the robotic group was associated with less blood loss and longer operative time. After the surgeon learning curves were overcome for each technique, the operative outcomes became similar between the two groups except longer operative time in the robotic group. After accumulating more cases of robotic gastrectomy, the operative time in the laparoscopic group decreased dramatically. Conclusions After overcoming the learning curves, the operative outcomes became similar between laparoscopic and robotic gastrectomy. The experience of robotic gastrectomy could affect the learning process of laparoscopic gastrectomy. PMID:25360767

Non-Markovian properties and multiscale hidden Markovian network buried in single molecule time series

NASA Astrophysics Data System (ADS)

Sultana, Tahmina; Takagi, Hiroaki; Morimatsu, Miki; Teramoto, Hiroshi; Li, Chun-Biu; Sako, Yasushi; Komatsuzaki, Tamiki

2013-12-01

We present a novel scheme to extract a multiscale state space network (SSN) from single-molecule time series. The multiscale SSN is a type of hidden Markov model that takes into account both multiple states buried in the measurement and memory effects in the process of the observable whenever they exist. Most biological systems function in a nonstationary manner across multiple timescales. Combined with a recently established nonlinear time series analysis based on information theory, a simple scheme is proposed to deal with the properties of multiscale and nonstationarity for a discrete time series. We derived an explicit analytical expression of the autocorrelation function in terms of the SSN. To demonstrate the potential of our scheme, we investigated single-molecule time series of dissociation and association kinetics between epidermal growth factor receptor (EGFR) on the plasma membrane and its adaptor protein Ash/Grb2 (Grb2) in an in vitro reconstituted system. We found that our formula successfully reproduces their autocorrelation function for a wide range of timescales (up to 3 s), and the underlying SSNs change their topographical structure as a function of the timescale; while the corresponding SSN is simple at the short timescale (0.033-0.1 s), the SSN at the longer timescales (0.1 s to ˜3 s) becomes rather complex in order to capture multiscale nonstationary kinetics emerging at longer timescales. It is also found that visiting the unbound form of the EGFR-Grb2 system approximately resets all information of history or memory of the process.

Three-dimensional numerical and experimental studies on transient ignition of hybrid rocket motor

NASA Astrophysics Data System (ADS)

Tian, Hui; Yu, Ruipeng; Zhu, Hao; Wu, Junfeng; Cai, Guobiao

2017-11-01

This paper presents transient simulations and experimental studies of the ignition process of the hybrid rocket motors (HRMs) using 90% hydrogen peroxide (HP) as the oxidizer and polymethyl methacrylate (PMMA) and Polyethylene (PE) as fuels. A fluid-solid coupling numerically method is established based on the conserved form of the three-dimensional unsteady Navier-Stokes (N-S) equations, considering gas fluid with chemical reactions and heat transfer between the fluid and solid region. Experiments are subsequently conducted using high-speed camera to record the ignition process. The flame propagation, chamber pressurizing process and average fuel regression rate of the numerical simulation results show good agreement with the experimental ones, which demonstrates the validity of the simulations in this study. The results also indicate that the flame propagation time is mainly affected by fluid dynamics and it increases with an increasing grain port area. The chamber pressurizing process begins when the flame propagation completes in the grain port. Furthermore, the chamber pressurizing time is about 4 times longer than the time of flame propagation.

Serious games for elderly continuous monitoring.

PubMed

Lemus-Zúñiga, Lenin-G; Navarro-Pardo, Esperanza; Moret-Tatay, Carmen; Pocinho, Ricardo

2015-01-01

Information technology (IT) and serious games allow older population to remain independent for longer. Hence, when designing technology for this population, developmental changes, such as attention and/or perception, should be considered. For instance, a crucial developmental change has been related to cognitive speed in terms of reaction time (RT). However, this variable presents a skewed distribution that difficult data analysis. An alternative strategy is to characterize the data to an ex-Gaussian function. Furthermore, this procedure provides different parameters that have been related to underlying cognitive processes in the literature. Another issue to be considered is the optimal data recording, storing and processing. For that purpose mobile devices (smart phones and tablets) are a good option for targeting serious games where valuable information can be stored (time spent in the application, reaction time, frequency of use, and a long etcetera). The data stored inside the smartphones and tablets can be sent to a central computer (cloud storage) in order to store the data collected to not only fill the distribution of reaction times to mathematical functions, but also to estimate parameters which may reflect cognitive processes underlying language, aging, and decisional process.

IL8 and IL16 levels indicate serum and plasma quality.

PubMed

Kofanova, Olga; Henry, Estelle; Quesada, Rocio Aguilar; Bulla, Alexandre; Linares, Hector Navarro; Lescuyer, Pierre; Shea, Kathi; Stone, Mars; Tybring, Gunnel; Bellora, Camille; Betsou, Fay

2018-02-09

Longer pre-centrifugation times alter the quality of serum and plasma samples. Markers for such delays in sample processing and hence for the sample quality, have been identified. Twenty cytokines in serum, EDTA plasma and citrate plasma samples were screened for changes in concentration induced by extended blood pre-centrifugation delays at room temperature. The two cytokines that showed the largest changes were further validated for their "diagnostic performance" in identifying serum or plasma samples with extended pre-centrifugation times. In this study, using R&D Systems ELISA kits, EDTA plasma samples and serum samples with a pre-centrifugation delay longer than 24 h had an IL16 concentration higher than 313 pg/mL, and an IL8 concentration higher than 125 pg/mL, respectively. EDTA plasma samples with a pre-centrifugation delay longer than 48 h had an IL16 concentration higher than 897 pg/mL, citrate plasma samples had an IL8 concentration higher than 21.5 pg/mL and serum samples had an IL8 concentration higher than 528 pg/mL. These robust and accurate tools, based on simple and commercially available ELISA assays can greatly facilitate qualification of serum and plasma legacy collections with undocumented pre-analytics.

Why sauropods had long necks; and why giraffes have short necks.

PubMed

Taylor, Michael P; Wedel, Mathew J

2013-01-01

The necks of the sauropod dinosaurs reached 15 m in length: six times longer than that of the world record giraffe and five times longer than those of all other terrestrial animals. Several anatomical features enabled this extreme elongation, including: absolutely large body size and quadrupedal stance providing a stable platform for a long neck; a small, light head that did not orally process food; cervical vertebrae that were both numerous and individually elongate; an efficient air-sac-based respiratory system; and distinctive cervical architecture. Relevant features of sauropod cervical vertebrae include: pneumatic chambers that enabled the bone to be positioned in a mechanically efficient way within the envelope; and muscular attachments of varying importance to the neural spines, epipophyses and cervical ribs. Other long-necked tetrapods lacked important features of sauropods, preventing the evolution of longer necks: for example, giraffes have relatively small torsos and large, heavy heads, share the usual mammalian constraint of only seven cervical vertebrae, and lack an air-sac system and pneumatic bones. Among non-sauropods, their saurischian relatives the theropod dinosaurs seem to have been best placed to evolve long necks, and indeed their necks probably surpassed those of giraffes. But 150 million years of evolution did not suffice for them to exceed a relatively modest 2.5 m.

Why sauropods had long necks; and why giraffes have short necks

PubMed Central

Wedel, Mathew J.

2013-01-01

The necks of the sauropod dinosaurs reached 15 m in length: six times longer than that of the world record giraffe and five times longer than those of all other terrestrial animals. Several anatomical features enabled this extreme elongation, including: absolutely large body size and quadrupedal stance providing a stable platform for a long neck; a small, light head that did not orally process food; cervical vertebrae that were both numerous and individually elongate; an efficient air-sac-based respiratory system; and distinctive cervical architecture. Relevant features of sauropod cervical vertebrae include: pneumatic chambers that enabled the bone to be positioned in a mechanically efficient way within the envelope; and muscular attachments of varying importance to the neural spines, epipophyses and cervical ribs. Other long-necked tetrapods lacked important features of sauropods, preventing the evolution of longer necks: for example, giraffes have relatively small torsos and large, heavy heads, share the usual mammalian constraint of only seven cervical vertebrae, and lack an air-sac system and pneumatic bones. Among non-sauropods, their saurischian relatives the theropod dinosaurs seem to have been best placed to evolve long necks, and indeed their necks probably surpassed those of giraffes. But 150 million years of evolution did not suffice for them to exceed a relatively modest 2.5 m. PMID:23638372

Rehabilitation time before disability pension.

PubMed

Støver, Morten; Pape, Kristine; Johnsen, Roar; Fleten, Nils; Sund, Erik R; Claussen, Bjørgulf; Ose, Solveig Osborg; Bjørngaard, Johan Håkon

2012-10-30

The decision to grant a disability pension is usually the end of a long process of medical examinations, treatment and rehabilitation attempts. This study investigates to what extent the time spent on rehabilitation time prior to disability pension is associated with characteristics of the individual or the local employment and welfare office, measured as municipality variance. A study of 2,533 40 to 42 year olds who received disability pension over a period of 18 years. The logarithm of the rehabilitation time before granting a disability pension was analysed with multilevel regression. The rehabilitation time before a disability pension was granted ranged from 30 to 5,508 days. Baseline health characteristics were only moderately associated with rehabilitation time. Younger people and people with unemployment periods had longer rehabilitation time before a disability pension was granted. There were only minor differences in rehabilitation time between men and women and between different levels of education. Approximately 2% of the total variance in rehabilitation time could be attributed to the municipality of residence. There is a higher threshold for granting a disability pension to younger persons and those who are expecting periods of unemployment, which is reflected in the extended rehabilitation requirements for these groups. The longer rehabilitation period for persons with psychiatric disorders might reflect a lack of common knowledge on the working capacity of and the fitted rehabilitation programs for people with psychiatric disorders.

Rehabilitation time before disability pension

PubMed Central

2012-01-01

Background The decision to grant a disability pension is usually the end of a long process of medical examinations, treatment and rehabilitation attempts. This study investigates to what extent the time spent on rehabilitation time prior to disability pension is associated with characteristics of the individual or the local employment and welfare office, measured as municipality variance. Methods A study of 2,533 40 to 42 year olds who received disability pension over a period of 18 years. The logarithm of the rehabilitation time before granting a disability pension was analysed with multilevel regression. Results The rehabilitation time before a disability pension was granted ranged from 30 to 5,508 days. Baseline health characteristics were only moderately associated with rehabilitation time. Younger people and people with unemployment periods had longer rehabilitation time before a disability pension was granted. There were only minor differences in rehabilitation time between men and women and between different levels of education. Approximately 2% of the total variance in rehabilitation time could be attributed to the municipality of residence. Conclusions There is a higher threshold for granting a disability pension to younger persons and those who are expecting periods of unemployment, which is reflected in the extended rehabilitation requirements for these groups. The longer rehabilitation period for persons with psychiatric disorders might reflect a lack of common knowledge on the working capacity of and the fitted rehabilitation programs for people with psychiatric disorders. PMID:23110397

Looking into the crystal ball: future device learning using hybrid e-beam and optical lithography (Keynote Paper)

NASA Astrophysics Data System (ADS)

Steen, S. E.; McNab, S. J.; Sekaric, L.; Babich, I.; Patel, J.; Bucchignano, J.; Rooks, M.; Fried, D. M.; Topol, A. W.; Brancaccio, J. R.; Yu, R.; Hergenrother, J. M.; Doyle, J. P.; Nunes, R.; Viswanathan, R. G.; Purushothaman, S.; Rothwell, M. B.

2005-05-01

Semiconductor process development teams are faced with increasing process and integration complexity while the time between lithographic capability and volume production has remained more or less constant over the last decade. Lithography tools have often gated the volume checkpoint of a new device node on the ITRS roadmap. The processes have to be redeveloped after the tooling capability for the new groundrule is obtained since straight scaling is no longer sufficient. In certain cases the time window that the process development teams have is actually decreasing. In the extreme, some forecasts are showing that by the time the 45nm technology node is scheduled for volume production, the tooling vendors will just begin shipping the tools required for this technology node. To address this time pressure, IBM has implemented a hybrid-lithography strategy that marries the advantages of optical lithography (high throughput) with electron beam direct write lithography (high resolution and alignment capability). This hybrid-lithography scheme allows for the timely development of semiconductor processes for the 32nm node, and beyond. In this paper we will describe how hybrid lithography has enabled early process integration and device learning and how IBM applied e-beam & optical hybrid lithography to create the world's smallest working SRAM cell.

A Cartesian reflex assessment of face processing.

PubMed

Polewan, Robert J; Vigorito, Christopher M; Nason, Christopher D; Block, Richard A; Moore, John W

2006-03-01

Commands to blink were embedded within pictures of faces and simple geometric shapes or forms. The faces and shapes were conditioned stimuli (CSs), and the required responses were conditioned responses, or more properly, Cartesian reflexes (CRs). As in classical conditioning protocols, response times (RTs) were measured from CS onset. RTs provided a measure of the processing cost (PC) of attending to a CS. A PC is the extra time required to respond relative to RTs to unconditioned stimulus (US) commands presented alone. They reflect the interplay between attentional processing of the informational content of a CS and its signaling function with respect to the US command. This resulted in longer RTs to embedded commands. Differences between PCs of faces and geometric shapes represent a starting place for a new mental chronometry based on the traditional idea that differences in RT reflect differences in information processing.

Reversibility in Quantum Models of Stochastic Processes

NASA Astrophysics Data System (ADS)

Gier, David; Crutchfield, James; Mahoney, John; James, Ryan

Natural phenomena such as time series of neural firing, orientation of layers in crystal stacking and successive measurements in spin-systems are inherently probabilistic. The provably minimal classical models of such stochastic processes are ɛ-machines, which consist of internal states, transition probabilities between states and output values. The topological properties of the ɛ-machine for a given process characterize the structure, memory and patterns of that process. However ɛ-machines are often not ideal because their statistical complexity (Cμ) is demonstrably greater than the excess entropy (E) of the processes they represent. Quantum models (q-machines) of the same processes can do better in that their statistical complexity (Cq) obeys the relation Cμ >= Cq >= E. q-machines can be constructed to consider longer lengths of strings, resulting in greater compression. With code-words of sufficiently long length, the statistical complexity becomes time-symmetric - a feature apparently novel to this quantum representation. This result has ramifications for compression of classical information in quantum computing and quantum communication technology.

Fabrication of the planar angular rotator using the CMOS process

NASA Astrophysics Data System (ADS)

Dai, Ching-Liang; Chang, Chien-Liu; Chen, Hung-Lin; Chang, Pei-Zen

2002-05-01

In this investigation we propose a novel planar angular rotator fabricated by the conventional complementary metal-oxide semiconductor (CMOS) process. Following the 0.6 μm single poly triple metal (SPTM) CMOS process, the device is completed by a simple maskless, post-process etching step. The rotor of the planar angular rotator rotates around its geometric center with electrostatic actuation. The proposed design adopts an intelligent mechanism including the slider-crank system to permit simultaneous motion. The CMOS planar angular rotator could be driven with driving voltages of around 40 V. The design proposed here has a shorter response time and longer life, without problems of friction and wear, compared to the more common planar angular micromotor.

Scaling and clustering effects of extreme precipitation distributions

NASA Astrophysics Data System (ADS)

Zhang, Qiang; Zhou, Yu; Singh, Vijay P.; Li, Jianfeng

2012-08-01

SummaryOne of the impacts of climate change and human activities on the hydrological cycle is the change in the precipitation structure. Closely related to the precipitation structure are two characteristics: the volume (m) of wet periods (WPs) and the time interval between WPs or waiting time (t). Using daily precipitation data for a period of 1960-2005 from 590 rain gauge stations in China, these two characteristics are analyzed, involving scaling and clustering of precipitation episodes. Our findings indicate that m and t follow similar probability distribution curves, implying that precipitation processes are controlled by similar underlying thermo-dynamics. Analysis of conditional probability distributions shows a significant dependence of m and t on their previous values of similar volumes, and the dependence tends to be stronger when m is larger or t is longer. It indicates that a higher probability can be expected when high-intensity precipitation is followed by precipitation episodes with similar precipitation intensity and longer waiting time between WPs is followed by the waiting time of similar duration. This result indicates the clustering of extreme precipitation episodes and severe droughts or floods are apt to occur in groups.

Influence of Temperature and Backslopping Time on the Microbiota of a Type I Propagated Laboratory Wheat Sourdough Fermentation▿

PubMed Central

Vrancken, Gino; Rimaux, Tom; Weckx, Stefan; Leroy, Frédéric; De Vuyst, Luc

2011-01-01

Sourdough fermentation is a cereal fermentation that is characterized by the formation of stable yeast/lactic acid bacteria (LAB) associations. It is a unique process among food fermentations in that the LAB that mostly dominate these fermentations are heterofermentative. In the present study, four wheat sourdough fermentations were carried out under different conditions of temperature and backslopping time to determine their effect on the composition of the microbiota of the final sourdoughs. A substantial effect of temperature was observed. A fermentation with 10 backsloppings (once every 24 h) at 23°C resulted in a microbiota composed of Leuconostoc citreum as the dominant species, whereas fermentations at 30 and 37°C with backslopping every 24 h resulted in ecosystems dominated by Lactobacillus fermentum. Longer backslopping times (every 48 h at 30°C) resulted in a combination of Lactobacillus fermentum and Lactobacillus plantarum. Residual maltose remained present in all fermentations, except those with longer backslopping times, and ornithine was found in almost all fermentations, indicating enhanced sourdough-typical LAB activity. The sourdough-typical species Lactobacillus sanfranciscensis was not found. Finally, a nonflour origin for this species was hypothesized. PMID:21335386

mStroke: "Mobile Stroke"-Improving Acute Stroke Care with Smartphone Technology.

PubMed

Andrew, Benjamin Y; Stack, Colleen M; Yang, Julian P; Dodds, Jodi A

2017-07-01

This study aimed to evaluate the effect of method and time of system activation on clinical metrics in cases utilizing the Stop Stroke (Pulsara, Inc.) mobile acute stroke care coordination application. A retrospective cohort analysis of stroke codes at 12 medical centers using Stop Stroke from March 2013 to May 2016 was performed. Comparison of metrics (door-to-needle time [DTN] and door-to-CT time [DTC], and rate of DTN ≤ 60 minutes [goal DTN]) was performed between subgroups based on method (emergency medical service [EMS] versus emergency department [ED]) and time of activation. Effects were adjusted for confounders (age, sex, National Institutes of Health Stroke Scale [NIHSS] score) using multiple linear and logistic regression. The final dataset included 2589 cases. Cases activated by EMS were more severe (median NIHSS score 8 versus 4, P < .0001) and more likely to receive recombinant tissue plasminogen activator (20% versus 12%, P < .0001) than those with ED activation. After adjustment, cases with EMS activation had shorter DTC (6.1 minutes shorter, 95% CI [-10.3, -2]) and DTN (12.8 minutes shorter, 95% CI [-21, -4.6]) and were more likely to meet goal DTN (OR 1.83, 95% CI [1.1, 3]). Cases between 1200 and 1800 had longer DTC (7.7 minutes longer, 95% CI [2.4, 13]) and DTN (21.1 minutes longer, 95% CI [9.3, 33]), and reduced rate of goal DTN (OR .3, 95% CI [.15, .61]) compared to those between 0000 and 0600. Incorporating real-time prehospital data obtained via smartphone technology provides unique insight into acute stroke codes. Activation of mobile electronic stroke coordination in the field appears to promote a more expedited and successful care process. Copyright © 2017 National Stroke Association. Published by Elsevier Inc. All rights reserved.

Neurophysiological correlates of word processing deficits in isolated reading and isolated spelling disorders.

PubMed

Bakos, Sarolta; Landerl, Karin; Bartling, Jürgen; Schulte-Körne, Gerd; Moll, Kristina

2018-03-01

In consistent orthographies, isolated reading disorders (iRD) and isolated spelling disorders (iSD) are nearly as common as combined reading-spelling disorders (cRSD). However, the exact nature of the underlying word processing deficits in isolated versus combined literacy deficits are not well understood yet. We applied a phonological lexical decision task (including words, pseudohomophones, legal and illegal pseudowords) during ERP recording to investigate the neurophysiological correlates of lexical and sublexical word-processing in children with iRD, iSD and cRSD compared to typically developing (TD) 9-year-olds. TD children showed enhanced early sensitivity (N170) for word material and for the violation of orthographic rules compared to the other groups. Lexical orthographic effects (higher LPC amplitude for words than for pseudohomophones) were the same in the TD and iRD groups, although processing took longer in children with iRD. In the iSD and cRSD groups, lexical orthographic effects were evident and stable over time only for correctly spelled words. Orthographic representations were intact in iRD children, but word processing took longer compared to TD. Children with spelling disorders had partly missing orthographic representations. Our study is the first to specify the underlying neurophysiology of word processing deficits associated with isolated literacy deficits. Copyright © 2017 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.

Impact of Cold Ischemia Time in Kidney Transplants From Donation After Circulatory Death Donors.

PubMed

Kayler, Liise; Yu, Xia; Cortes, Carlos; Lubetzky, Michelle; Friedmann, Patricia

2017-07-01

Deceased-donor kidneys are exposed to ischemic events from donor instability during the process of donation after circulatory death (DCD). Clinicians may be reluctant to transplant DCD kidneys with prolonged cold ischemia time (CIT) for fear of an additional deleterious effect. We performed a retrospective cohort study examining US registry data between 1998 and 2013 of adult first-time kidney-only recipients of paired kidneys (derived from the same donor transplanted into different recipients) from DCD donors. On multivariable analysis, death-censored graft survival (DCGS) was comparable between recipients of kidneys with higher CIT relative to paired donor recipients with lower CIT when the CIT difference was 1 hour or longer (adjusted hazard ratio, [aHR], 1.02; 95% confidence interval [CI], 0.88-1.17; n = 6276), 5 hours or longer (aHR, 0.98; 95% CI, 0.80-1.19; n = 3130), 10 hours or longer (aHR, 1.15; 95% CI, 0.82-1.60; n = 1124) or 15 hours (aHR, 1.15; 95% CI, 0.66-1.99; n = 498). There was a higher rate of primary non function in the long CIT groups for delta 1 hour or longer (0.89% vs 1.63%; P = 0.006), 5 hours (1.09% vs 1.67%, P = 0.13); 10 hours (0.53% vs 1.78%; P = 0.03), and 15 hours (0.40% vs 1.61%; P = 0.18), respectively. Between each of the 4 delta CIT levels of shorter and longer CIT, there was a significantly and incrementally higher rate of delayed graft function in the long CIT groups for delta 1 hour or longer (37.3% vs 41.7%; P < 0.001), 5 hours (35.9% vs 42.7%; P < 0.001), 10 hours (29.4% vs 44.2%, P < 0.001), and 15 hours (29.6% vs 46.1%, P < 0.001), respectively. Overall patient survival was comparable with delta CITs of 1 hour or longer (aHR, 0.96; 95% CI, 0.84-1.08), 5 hours (aHR, 1.01; 95% CI, 0.85-1.20), and 15 hours (aHR, 1.27; 95% CI, 0.79-2.06) but not 10 hours (aHR, 1.47; 95% CI, 1.09-1.98). These results suggest that in the setting of a prior ischemic donor event, prolonged CIT has limited bearing on long-term outcomes.

Impact of Cold Ischemia Time in Kidney Transplants From Donation After Circulatory Death Donors

PubMed Central

Kayler, Liise; Yu, Xia; Cortes, Carlos; Lubetzky, Michelle; Friedmann, Patricia

2017-01-01

Background Deceased-donor kidneys are exposed to ischemic events from donor instability during the process of donation after circulatory death (DCD). Clinicians may be reluctant to transplant DCD kidneys with prolonged cold ischemia time (CIT) for fear of an additional deleterious effect. Methods We performed a retrospective cohort study examining US registry data between 1998 and 2013 of adult first-time kidney-only recipients of paired kidneys (derived from the same donor transplanted into different recipients) from DCD donors. Results On multivariable analysis, death-censored graft survival (DCGS) was comparable between recipients of kidneys with higher CIT relative to paired donor recipients with lower CIT when the CIT difference was 1 hour or longer (adjusted hazard ratio, [aHR], 1.02; 95% confidence interval [CI], 0.88-1.17; n = 6276), 5 hours or longer (aHR, 0.98; 95% CI, 0.80-1.19; n = 3130), 10 hours or longer (aHR, 1.15; 95% CI, 0.82-1.60; n = 1124) or 15 hours (aHR, 1.15; 95% CI, 0.66-1.99; n = 498). There was a higher rate of primary non function in the long CIT groups for delta 1 hour or longer (0.89% vs 1.63%; P = 0.006), 5 hours (1.09% vs 1.67%, P = 0.13); 10 hours (0.53% vs 1.78%; P = 0.03), and 15 hours (0.40% vs 1.61%; P = 0.18), respectively. Between each of the 4 delta CIT levels of shorter and longer CIT, there was a significantly and incrementally higher rate of delayed graft function in the long CIT groups for delta 1 hour or longer (37.3% vs 41.7%; P < 0.001), 5 hours (35.9% vs 42.7%; P < 0.001), 10 hours (29.4% vs 44.2%, P < 0.001), and 15 hours (29.6% vs 46.1%, P < 0.001), respectively. Overall patient survival was comparable with delta CITs of 1 hour or longer (aHR, 0.96; 95% CI, 0.84-1.08), 5 hours (aHR, 1.01; 95% CI, 0.85-1.20), and 15 hours (aHR, 1.27; 95% CI, 0.79-2.06) but not 10 hours (aHR, 1.47; 95% CI, 1.09-1.98). Conclusions These results suggest that in the setting of a prior ischemic donor event, prolonged CIT has limited bearing on long-term outcomes. PMID:28706980

Validation of Models Used to Inform Colorectal Cancer Screening Guidelines: Accuracy and Implications.

PubMed

Rutter, Carolyn M; Knudsen, Amy B; Marsh, Tracey L; Doria-Rose, V Paul; Johnson, Eric; Pabiniak, Chester; Kuntz, Karen M; van Ballegooijen, Marjolein; Zauber, Ann G; Lansdorp-Vogelaar, Iris

2016-07-01

Microsimulation models synthesize evidence about disease processes and interventions, providing a method for predicting long-term benefits and harms of prevention, screening, and treatment strategies. Because models often require assumptions about unobservable processes, assessing a model's predictive accuracy is important. We validated 3 colorectal cancer (CRC) microsimulation models against outcomes from the United Kingdom Flexible Sigmoidoscopy Screening (UKFSS) Trial, a randomized controlled trial that examined the effectiveness of one-time flexible sigmoidoscopy screening to reduce CRC mortality. The models incorporate different assumptions about the time from adenoma initiation to development of preclinical and symptomatic CRC. Analyses compare model predictions to study estimates across a range of outcomes to provide insight into the accuracy of model assumptions. All 3 models accurately predicted the relative reduction in CRC mortality 10 years after screening (predicted hazard ratios, with 95% percentile intervals: 0.56 [0.44, 0.71], 0.63 [0.51, 0.75], 0.68 [0.53, 0.83]; estimated with 95% confidence interval: 0.56 [0.45, 0.69]). Two models with longer average preclinical duration accurately predicted the relative reduction in 10-year CRC incidence. Two models with longer mean sojourn time accurately predicted the number of screen-detected cancers. All 3 models predicted too many proximal adenomas among patients referred to colonoscopy. Model accuracy can only be established through external validation. Analyses such as these are therefore essential for any decision model. Results supported the assumptions that the average time from adenoma initiation to development of preclinical cancer is long (up to 25 years), and mean sojourn time is close to 4 years, suggesting the window for early detection and intervention by screening is relatively long. Variation in dwell time remains uncertain and could have important clinical and policy implications. © The Author(s) 2016.

X-ray reflectivity measurement of interdiffusion in metallic multilayers during rapid heating

PubMed Central

Liu, J. P.; Kirchhoff, J.; Zhou, L.; Zhao, M.; Grapes, M. D.; Dale, D. S.; Tate, M. D.; Philipp, H. T.; Gruner, S. M.; Weihs, T. P.; Hufnagel, T. C.

2017-01-01

A technique for measuring interdiffusion in multilayer materials during rapid heating using X-ray reflectivity is described. In this technique the sample is bent to achieve a range of incident angles simultaneously, and the scattered intensity is recorded on a fast high-dynamic-range mixed-mode pixel array detector. Heating of the multilayer is achieved by electrical resistive heating of the silicon substrate, monitored by an infrared pyrometer. As an example, reflectivity data from Al/Ni heated at rates up to 200 K s−1 are presented. At short times the interdiffusion coefficient can be determined from the rate of decay of the reflectivity peaks, and it is shown that the activation energy for interdiffusion is consistent with a grain boundary diffusion mechanism. At longer times the simple analysis no longer applies because the evolution of the reflectivity pattern is complicated by other processes, such as nucleation and growth of intermetallic phases. PMID:28664887

Modeling competitive substitution in a polyelectrolyte complex

DOE Office of Scientific and Technical Information (OSTI.GOV)

Peng, B.; Muthukumar, M., E-mail: muthu@polysci.umass.edu

2015-12-28

We have simulated the invasion of a polyelectrolyte complex made of a polycation chain and a polyanion chain, by another longer polyanion chain, using the coarse-grained united atom model for the chains and the Langevin dynamics methodology. Our simulations reveal many intricate details of the substitution reaction in terms of conformational changes of the chains and competition between the invading chain and the chain being displaced for the common complementary chain. We show that the invading chain is required to be sufficiently longer than the chain being displaced for effecting the substitution. Yet, having the invading chain to be longermore » than a certain threshold value does not reduce the substitution time much further. While most of the simulations were carried out in salt-free conditions, we show that presence of salt facilitates the substitution reaction and reduces the substitution time. Analysis of our data shows that the dominant driving force for the substitution process involving polyelectrolytes lies in the release of counterions during the substitution.« less

X-ray reflectivity measurement of interdiffusion in metallic multilayers during rapid heating

DOE PAGES

Liu, J. P.; Kirchhoff, J.; Zhou, L.; ...

2017-06-15

A technique for measuring interdiffusion in multilayer materials during rapid heating using X-ray reflectivity is described. In this technique the sample is bent to achieve a range of incident angles simultaneously, and the scattered intensity is recorded on a fast high-dynamic-range mixed-mode pixel array detector. Heating of the multilayer is achieved by electrical resistive heating of the silicon substrate, monitored by an infrared pyrometer. As an example, reflectivity data from Al/Ni heated at rates up to 200 K s -1 are presented. At short times the interdiffusion coefficient can be determined from the rate of decay of the reflectivity peaks,more » and it is shown that the activation energy for interdiffusion is consistent with a grain boundary diffusion mechanism. At longer times the simple analysis no longer applies because the evolution of the reflectivity pattern is complicated by other processes, such as nucleation and growth of intermetallic phases.« less

Electrophysiology of Memory-Updating Differs with Age

PubMed Central

Steiner, Genevieve Z.; Gonsalvez, Craig J.; De Blasio, Frances M.; Barry, Robert J.

2016-01-01

In oddball tasks, the P3 component of the event-related potential systematically varies with the time between target stimuli—the target-to-target interval (TTI). Longer TTIs result in larger P3 amplitudes and shorter latencies, and this pattern of results has been linked with working memory-updating processes. Given that working memory and the P3 have both been shown to diminish with age, the current study aimed to determine whether the linear relationship between P3 and TTI is compromised in healthy aging by comparing TTI effects on P3 amplitudes and latencies, and reaction time (RT), in young and older adults. Older adults were found to have an overall reduction in P3 amplitudes, longer latencies, an anterior shift in topography, a trend toward slower RTs, and a flatter linear relationship between P3 and TTI than young adults. Results suggest that the ability to maintain templates in working memory required for stimulus categorization decreases with age, and that as a result, neural compensatory mechanisms are employed. PMID:27378908

Temporal and Cross Correlations in Business News

NASA Astrophysics Data System (ADS)

Mizuno, T.; Takei, K.; Ohnishi, T.; Watanabe, T.

We empirically investigate temporal and cross correlations inthe frequency of news reports on companies, using a dataset of more than 100 million news articles reported in English by around 500 press agencies worldwide for the period 2003--2009. Our first finding is that the frequency of news reports on a company does not follow a Poisson process, but instead exhibits long memory with a positive autocorrelation for longer than one year. The second finding is that there exist significant correlations in the frequency of news across companies. Specifically, on a daily time scale or longer the frequency of news is governed by external dynamics, while on a time scale of minutes it is governed by internal dynamics. These two findings indicate that the frequency of news reports on companies has statistical properties similar to trading volume or price volatility in stock markets, suggesting that the flow of information through company news plays an important role in price dynamics in stock markets.

Electrophysiology of Memory-Updating Differs with Age.

PubMed

Steiner, Genevieve Z; Gonsalvez, Craig J; De Blasio, Frances M; Barry, Robert J

2016-01-01

In oddball tasks, the P3 component of the event-related potential systematically varies with the time between target stimuli-the target-to-target interval (TTI). Longer TTIs result in larger P3 amplitudes and shorter latencies, and this pattern of results has been linked with working memory-updating processes. Given that working memory and the P3 have both been shown to diminish with age, the current study aimed to determine whether the linear relationship between P3 and TTI is compromised in healthy aging by comparing TTI effects on P3 amplitudes and latencies, and reaction time (RT), in young and older adults. Older adults were found to have an overall reduction in P3 amplitudes, longer latencies, an anterior shift in topography, a trend toward slower RTs, and a flatter linear relationship between P3 and TTI than young adults. Results suggest that the ability to maintain templates in working memory required for stimulus categorization decreases with age, and that as a result, neural compensatory mechanisms are employed.

Simulating complex atomistic processes: On-the-fly kinetic Monte Carlo scheme with selective active volumes

NASA Astrophysics Data System (ADS)

Xu, Haixuan; Osetsky, Yury N.; Stoller, Roger E.

2011-10-01

An accelerated atomistic kinetic Monte Carlo (KMC) approach for evolving complex atomistic structures has been developed. The method incorporates on-the-fly calculations of transition states (TSs) with a scheme for defining active volumes (AVs) in an off-lattice (relaxed) system. In contrast to conventional KMC models that require all reactions to be predetermined, this approach is self-evolving and any physically relevant motion or reaction may occur. Application of this self-evolving atomistic kinetic Monte Carlo (SEAK-MC) approach is illustrated by predicting the evolution of a complex defect configuration obtained in a molecular dynamics (MD) simulation of a displacement cascade in Fe. Over much longer times, it was shown that interstitial clusters interacting with other defects may change their structure, e.g., from glissile to sessile configuration. The direct comparison with MD modeling confirms the atomistic fidelity of the approach, while the longer time simulation demonstrates the unique capability of the model.

4D visualization of embryonic, structural crystallization by single-pulse microscopy

PubMed Central

Kwon, Oh-Hoon; Barwick, Brett; Park, Hyun Soon; Baskin, J. Spencer; Zewail, Ahmed H.

2008-01-01

In many physical and biological systems the transition from an amorphous to ordered native structure involves complex energy landscapes, and understanding such transformations requires not only their thermodynamics but also the structural dynamics during the process. Here, we extend our 4D visualization method with electron imaging to include the study of irreversible processes with a single pulse in the same ultrafast electron microscope (UEM) as used before in the single-electron mode for the study of reversible processes. With this augmentation, we report on the transformation of amorphous to crystalline structure with silicon as an example. A single heating pulse was used to initiate crystallization from the amorphous phase while a single packet of electrons imaged selectively in space the transformation as the structure continuously changes with time. From the evolution of crystallinity in real time and the changes in morphology, for nanosecond and femtosecond pulse heating, we describe two types of processes, one that occurs at early time and involves a nondiffusive motion and another that takes place on a longer time scale. Similar mechanisms of two distinct time scales may perhaps be important in biomolecular folding. PMID:18562291

Atomistic details of protein dynamics and the role of hydration water

DOE PAGES

Khodadadi, Sheila; Sokolov, Alexei P.

2016-05-04

The importance of protein dynamics for their biological activity is nowwell recognized. Different experimental and computational techniques have been employed to study protein dynamics, hierarchy of different processes and the coupling between protein and hydration water dynamics. But, understanding the atomistic details of protein dynamics and the role of hydration water remains rather limited. Based on overview of neutron scattering, molecular dynamic simulations, NMR and dielectric spectroscopy results we present a general picture of protein dynamics covering time scales from faster than ps to microseconds and the influence of hydration water on different relaxation processes. Internal protein dynamics spread overmore » a wide time range fromfaster than picosecond to longer than microseconds. We suggest that the structural relaxation in hydrated proteins appears on the microsecond time scale, while faster processes present mostly motion of side groups and some domains. Hydration water plays a crucial role in protein dynamics on all time scales. It controls the coupled protein-hydration water relaxation on 10 100 ps time scale. Our process defines the friction for slower protein dynamics. Analysis suggests that changes in amount of hydration water affect not only general friction, but also influence significantly the protein's energy landscape.« less

Atomistic details of protein dynamics and the role of hydration water

DOE Office of Scientific and Technical Information (OSTI.GOV)

Khodadadi, Sheila; Sokolov, Alexei P.

The importance of protein dynamics for their biological activity is nowwell recognized. Different experimental and computational techniques have been employed to study protein dynamics, hierarchy of different processes and the coupling between protein and hydration water dynamics. But, understanding the atomistic details of protein dynamics and the role of hydration water remains rather limited. Based on overview of neutron scattering, molecular dynamic simulations, NMR and dielectric spectroscopy results we present a general picture of protein dynamics covering time scales from faster than ps to microseconds and the influence of hydration water on different relaxation processes. Internal protein dynamics spread overmore » a wide time range fromfaster than picosecond to longer than microseconds. We suggest that the structural relaxation in hydrated proteins appears on the microsecond time scale, while faster processes present mostly motion of side groups and some domains. Hydration water plays a crucial role in protein dynamics on all time scales. It controls the coupled protein-hydration water relaxation on 10 100 ps time scale. Our process defines the friction for slower protein dynamics. Analysis suggests that changes in amount of hydration water affect not only general friction, but also influence significantly the protein's energy landscape.« less

Seeing Emotion with Your Ears: Emotional Prosody Implicitly Guides Visual Attention to Faces

PubMed Central

Rigoulot, Simon; Pell, Marc D.

2012-01-01

Interpersonal communication involves the processing of multimodal emotional cues, particularly facial expressions (visual modality) and emotional speech prosody (auditory modality) which can interact during information processing. Here, we investigated whether the implicit processing of emotional prosody systematically influences gaze behavior to facial expressions of emotion. We analyzed the eye movements of 31 participants as they scanned a visual array of four emotional faces portraying fear, anger, happiness, and neutrality, while listening to an emotionally-inflected pseudo-utterance (Someone migged the pazing) uttered in a congruent or incongruent tone. Participants heard the emotional utterance during the first 1250 milliseconds of a five-second visual array and then performed an immediate recall decision about the face they had just seen. The frequency and duration of first saccades and of total looks in three temporal windows ([0–1250 ms], [1250–2500 ms], [2500–5000 ms]) were analyzed according to the emotional content of faces and voices. Results showed that participants looked longer and more frequently at faces that matched the prosody in all three time windows (emotion congruency effect), although this effect was often emotion-specific (with greatest effects for fear). Effects of prosody on visual attention to faces persisted over time and could be detected long after the auditory information was no longer present. These data imply that emotional prosody is processed automatically during communication and that these cues play a critical role in how humans respond to related visual cues in the environment, such as facial expressions. PMID:22303454

Initiating statistical process control to improve quality outcomes in colorectal surgery.

PubMed

Keller, Deborah S; Stulberg, Jonah J; Lawrence, Justin K; Samia, Hoda; Delaney, Conor P

2015-12-01

Unexpected variations in postoperative length of stay (LOS) negatively impact resources and patient outcomes. Statistical process control (SPC) measures performance, evaluates productivity, and modifies processes for optimal performance. The goal of this study was to initiate SPC to identify LOS outliers and evaluate its feasibility to improve outcomes in colorectal surgery. Review of a prospective database identified colorectal procedures performed by a single surgeon. Patients were grouped into elective and emergent categories and then stratified by laparoscopic and open approaches. All followed a standardized enhanced recovery protocol. SPC was applied to identify outliers and evaluate causes within each group. A total of 1294 cases were analyzed--83% elective (n = 1074) and 17% emergent (n = 220). Emergent cases were 70.5% open and 29.5% laparoscopic; elective cases were 36.8% open and 63.2% laparoscopic. All groups had a wide range in LOS. LOS outliers ranged from 8.6% (elective laparoscopic) to 10.8% (emergent laparoscopic). Evaluation of outliers demonstrated patient characteristics of higher ASA scores, longer operating times, ICU requirement, and temporary nursing at discharge. Outliers had higher postoperative complication rates in elective open (57.1 vs. 20.0%) and elective lap groups (77.6 vs. 26.1%). Outliers also had higher readmission rates for emergent open (11.4 vs. 5.4%), emergent lap (14.3 vs. 9.2%), and elective lap (32.8 vs. 6.9%). Elective open outliers did not follow trends of longer LOS or higher reoperation rates. SPC is feasible and promising for improving colorectal surgery outcomes. SPC identified patient and process characteristics associated with increased LOS. SPC may allow real-time outlier identification, during quality improvement efforts, and reevaluation of outcomes after introducing process change. SPC has clinical implications for improving patient outcomes and resource utilization.

Facile fabrication of superhydrophobic films with fractal structures using epoxy resin microspheres

NASA Astrophysics Data System (ADS)

Quan, Yun-Yun; Zhang, Li-Zhi

2014-02-01

A simple method has been developed to fabricate superhydrophobic surfaces with fractal structures with epoxy resin microspheres (ERMs). The ERMs is produced by phase separation in an epoxy-amine curing system with a silica sol (SS) dispersant. The transparent epoxy solution becomes cloudy and turns into epoxy suspension (ES) in this process. The fractal structure (two tier structure) generated by synthetic epoxy resin microspheres (ERMs) and deposited nanoincrutations on the surfaces of these ERMs, which have been observed by scanning electron microscope (SEM). The curing time of ES is an important condition to obtain films with good comprehensive performances. Superhydrophobic films can be prepared by adding extra SS into ES with a curing time longer than 5 h. The optimal curing time is 10 h to fabricate a film with good mechanical stability and high superhydrophobicity. In addition, a surface with anti-wetting property of impacting microdroplets can be fabricated by prolonging the curing time of ES to 24 h. The gradually decreased hydrophilic groups resulted from a longer curing time enable the surface to have smaller surface adhesions to water droplets, which is the main reason to keep its superhydrophobicity under impacting conditions. The coated surface is highly hydrophobic and the impacting water droplets are bounced off from the surface.

Effects of tip-substrate gap, deposition temperature, holding time, and pull-off velocity on dip-pen lithography investigated using molecular dynamics simulation

NASA Astrophysics Data System (ADS)

Wu, Cheng-Da; Fang, Te-Hua; Lin, Jen-Fin

2012-05-01

The process parameters in the dip-pen nanolithography process, including tip-substrate gap, deposition temperature, holding time, and pull-off velocity are evaluated in terms of the mechanism of molecular transference, alkanethiol meniscus characteristic, surface adsorbed energy, and pattern formation using molecular dynamics simulations. The simulation results clearly show that the optimum deposition occurs at a smaller tip-substrate gap, a slower pull-off velocity, a higher temperature, and a longer holding time. The pattern area increases with decreasing tip-substrate gap and increasing deposition temperature and holding time. With an increase in deposition temperature, the molecular transfer ability significantly increases. Pattern height is a function of meniscus length. When the pull-off velocity is decreased, the pattern height increases. The height of the neck in meniscus decreases and the neck width increases with holding time. Meniscus size increases with increasing deposition temperature and holding time.

Duration of extinction trials as a determinant of instrumental extinction in terrestrial toads (Rhinella arenarum).

PubMed

Puddington, Martín M; Papini, Mauricio R; Muzio, Rubén N

2018-01-01

Instrumental learning guides behavior toward resources. When such resources are no longer available, approach to previously reinforced locations is reduced, a process called extinction. The present experiments are concerned with factors affecting the extinction of acquired behaviors in toads. In previous experiments, total reward magnitude in acquisition and duration of extinction trials were confounded. The present experiments were designed to test the effects of these factors in factorial designs. Experiment 1 varied reward magnitude (900, 300, or 100 s of water access per trial) and amount of acquisition training (5 or 15 daily trials). With total amount of water access equated in acquisition, extinction with large rewards was faster (longer latencies in 900/5 than 300/15), but with total amount of training equated, extinction with small rewards was faster (longer latencies in 100/15 than 300/15). Experiment 2 varied reward magnitude (1200 or 120 s of water access per trial) while holding constant the number of acquisition trials (5 daily trials) and the duration of extinction trials (300 s). Extinction performance was lower with small, rather than large reward magnitude (longer latencies in 120/300 than in 1200/300). Thus, instrumental extinction depends upon the amount of time toads are exposed to the empty goal compartment during extinction trials.

Process intensification of biodiesel production by using microwave and ionic liquids as catalyst

DOE Office of Scientific and Technical Information (OSTI.GOV)

Handayani, Prima Astuti; Chemical Engineering Program, Faculty of Engineering, Semarang State University; Abdullah

The energy crisis pushes the development and intensification of biodiesel production process. Biodiesel is produced by transesterification of vegetable oils or animal fats and conventionally produced by using acid/base catalyst. However, the conventional method requires longer processing time and obtains lower yield of biodiesel. The microwave has been intensively used to accelerate production process and ionic liquids has been introduced as source of catalyst. This paper discusses the overview of the development of biodiesel production through innovation using microwave irradiation and ionic liquids catalyst to increase the yield of biodiesel. The potential microwave to reduce the processing time will bemore » discussed and compared with other energy power, while the ionic liquids as a new generation of catalysts in the chemical industry will be also discussed for its use. The ionic liquids has potential to enhance the economic and environmental aspects because it has a low corrosion effect, can be recycled, and low waste form.« less

Process intensification of biodiesel production by using microwave and ionic liquids as catalyst

NASA Astrophysics Data System (ADS)

Handayani, Prima Astuti; Abdullah, dan Hadiyanto

2015-12-01

The energy crisis pushes the development and intensification of biodiesel production process. Biodiesel is produced by transesterification of vegetable oils or animal fats and conventionally produced by using acid/base catalyst. However, the conventional method requires longer processing time and obtains lower yield of biodiesel. The microwave has been intensively used to accelerate production process and ionic liquids has been introduced as source of catalyst. This paper discusses the overview of the development of biodiesel production through innovation using microwave irradiation and ionic liquids catalyst to increase the yield of biodiesel. The potential microwave to reduce the processing time will be discussed and compared with other energy power, while the ionic liquids as a new generation of catalysts in the chemical industry will be also discussed for its use. The ionic liquids has potential to enhance the economic and environmental aspects because it has a low corrosion effect, can be recycled, and low waste form.

Grammatical verb aspect and event roles in sentence processing.

PubMed

Madden-Lombardi, Carol; Dominey, Peter Ford; Ventre-Dominey, Jocelyne

2017-01-01

Two experiments examine how grammatical verb aspect constrains our understanding of events. According to linguistic theory, an event described in the perfect aspect (John had opened the bottle) should evoke a mental representation of a finished event with focus on the resulting object, whereas an event described in the imperfective aspect (John was opening the bottle) should evoke a representation of the event as ongoing, including all stages of the event, and focusing all entities relevant to the ongoing action (instruments, objects, agents, locations, etc.). To test this idea, participants saw rebus sentences in the perfect and imperfective aspect, presented one word at a time, self-paced. In each sentence, the instrument and the recipient of the action were replaced by pictures (John was using/had used a *corkscrew* to open the *bottle* at the restaurant). Time to process the two images as well as speed and accuracy on sensibility judgments were measured. Although experimental sentences always made sense, half of the object and instrument pictures did not match the temporal constraints of the verb. For instance, in perfect sentences aspect-congruent trials presented an image of the corkscrew closed (no longer in-use) and the wine bottle fully open. The aspect-incongruent yet still sensible versions either replaced the corkscrew with an in-use corkscrew (open, in-hand) or the bottle image with a half-opened bottle. In this case, the participant would still respond "yes", but with longer expected response times. A three-way interaction among Verb Aspect, Sentence Role, and Temporal Match on image processing times showed that participants were faster to process images that matched rather than mismatched the aspect of the verb, especially for resulting objects in perfect sentences. A second experiment replicated and extended the results to confirm that this was not due to the placement of the object in the sentence. These two experiments extend previous research, showing how verb aspect drives not only the temporal structure of event representation, but also the focus on specific roles of the event. More generally, the findings of visual match during online sentence-picture processing are consistent with theories of perceptual simulation.

Grammatical verb aspect and event roles in sentence processing

PubMed Central

Madden-Lombardi, Carol; Dominey, Peter Ford; Ventre-Dominey, Jocelyne

2017-01-01

Two experiments examine how grammatical verb aspect constrains our understanding of events. According to linguistic theory, an event described in the perfect aspect (John had opened the bottle) should evoke a mental representation of a finished event with focus on the resulting object, whereas an event described in the imperfective aspect (John was opening the bottle) should evoke a representation of the event as ongoing, including all stages of the event, and focusing all entities relevant to the ongoing action (instruments, objects, agents, locations, etc.). To test this idea, participants saw rebus sentences in the perfect and imperfective aspect, presented one word at a time, self-paced. In each sentence, the instrument and the recipient of the action were replaced by pictures (John was using/had used a *corkscrew* to open the *bottle* at the restaurant). Time to process the two images as well as speed and accuracy on sensibility judgments were measured. Although experimental sentences always made sense, half of the object and instrument pictures did not match the temporal constraints of the verb. For instance, in perfect sentences aspect-congruent trials presented an image of the corkscrew closed (no longer in-use) and the wine bottle fully open. The aspect-incongruent yet still sensible versions either replaced the corkscrew with an in-use corkscrew (open, in-hand) or the bottle image with a half-opened bottle. In this case, the participant would still respond “yes”, but with longer expected response times. A three-way interaction among Verb Aspect, Sentence Role, and Temporal Match on image processing times showed that participants were faster to process images that matched rather than mismatched the aspect of the verb, especially for resulting objects in perfect sentences. A second experiment replicated and extended the results to confirm that this was not due to the placement of the object in the sentence. These two experiments extend previous research, showing how verb aspect drives not only the temporal structure of event representation, but also the focus on specific roles of the event. More generally, the findings of visual match during online sentence-picture processing are consistent with theories of perceptual simulation. PMID:29287091

Conformity and Dissonance in Generalized Voter Models

NASA Astrophysics Data System (ADS)

Page, Scott E.; Sander, Leonard M.; Schneider-Mizell, Casey M.

2007-09-01

We generalize the voter model to include social forces that produce conformity among voters and avoidance of cognitive dissonance of opinions within a voter. The time for both conformity and consistency (which we call the exit time) is, in general, much longer than for either process alone. We show that our generalized model can be applied quite widely: it is a form of Wright's island model of population genetics, and is related to problems in the physical sciences. We give scaling arguments, numerical simulations, and analytic estimates for the exit time for a range of relative strengths in the tendency to conform and to avoid dissonance.

Accelerating the spin-up of the coupled carbon and nitrogen cycle model in CLM4

DOE PAGES

Fang, Yilin; Liu, Chongxuan; Leung, Lai-Yung R.

2015-03-24

The commonly adopted biogeochemistry spin-up process in an Earth system model (ESM) is to run the model for hundreds to thousands of years subject to periodic atmospheric forcing to reach dynamic steady state of the carbon–nitrogen (CN) models. A variety of approaches have been proposed to reduce the computation time of the spin-up process. Significant improvement in computational efficiency has been made recently. However, a long simulation time is still required to reach the common convergence criteria of the coupled carbon–nitrogen model. A gradient projection method was proposed and used to further reduce the computation time after examining the trendmore » of the dominant carbon pools. The Community Land Model version 4 (CLM4) with a carbon and nitrogen component was used in this study. From point-scale simulations, we found that the method can reduce the computation time by 20–69% compared to one of the fastest approaches in the literature. We also found that the cyclic stability of total carbon for some cases differs from that of the periodic atmospheric forcing, and some cases even showed instability. Close examination showed that one case has a carbon periodicity much longer than that of the atmospheric forcing due to the annual fire disturbance that is longer than half a year. The rest was caused by the instability of water table calculation in the hydrology model of CLM4. The instability issue is resolved after we replaced the hydrology scheme in CLM4 with a flow model for variably saturated porous media.« less

Investigations to improve laser induced lithrotripsy (Conference Presentation)

NASA Astrophysics Data System (ADS)

Eisel, Max; Ulaganathan, Keerthanan; Strittmatter, Frank; Pongratz, Thomas; Sroka, Ronald

2017-02-01

Laser lithotripsy is the preferred application for the destruction of ureteral and kidney stones. Clinically Ho:YAG lasers (λ=2.1μm) are used due to high absorption by water to induce thermomechanical ablation. This study focussed on the investigation of different laser parameters in relation to the stone dusting efficiency. The term dusting was defined when the ablated fragments were d<1mm in diameter while fragmentation is defined to pieces of d> 1mm. The discussion about fragment-size showed advantages like reduced surgery time. Experiments were performed using clinical available Ho:YAG laser energy transferred via a standard fibre (Ø: 365μm) onto phantom calculi (Bego-Stones of different hardness) in a water filled vessel. Dusting can be reached most efficient by using low energy/pulse (approx. 0.5J/pulse) and repetition rate of around 40 Hz. Higher energy/pulse showed strong repulsion and thereby increased mobility, while using lower repetition rates result in longer ablation times. With regard to the hardness of the phantoms it can be derived that on soft calculi or calculi with a very rugged surface dusting can be observed less because the stone breaks into large fragments after a short time of laser application. For hard calculi the ablation process takes a much longer time compared to soft stones. In the following will be shown that dusting and fragmentation process depends not only on the energy/pulse and repetition rate of a Ho:YAG-laser, but also there are differences between Ho:YAG-laser systems according to the dusting efficiency.

Recrystallization-Induced Surface Cracks of Carbon Ions Irradiated 6H-SiC after Annealing

PubMed Central

Ye, Chao; Ran, Guang; Zhou, Wei; Shen, Qiang; Feng, Qijie; Lin, Jianxin

2017-01-01

Single crystal 6H-SiC wafers with 4° off-axis [0001] orientation were irradiated with carbon ions and then annealed at 900 °C for different time periods. The microstructure and surface morphology of these samples were investigated by grazing incidence X-ray diffraction (GIXRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). Ion irradiation induced SiC amorphization, but the surface was smooth and did not have special structures. During the annealing process, the amorphous SiC was recrystallized to form columnar crystals that had a large amount of twin structures. The longer the annealing time was, the greater the amount of recrystallized SiC would be. The recrystallization volume fraction was accorded with the law of the Johnson–Mehl–Avrami equation. The surface morphology consisted of tiny pieces with an average width of approximately 30 nm in the annealed SiC. The volume shrinkage of irradiated SiC layer and the anisotropy of newly born crystals during annealing process produced internal stress and then induced not only a large number of dislocation walls in the non-irradiated layer but also the initiation and propagation of the cracks. The direction of dislocation walls was perpendicular to the growth direction of the columnar crystal. The longer the annealing time was, the larger the length and width of the formed crack would be. A quantitative model of the crack growth was provided to calculate the length and width of the cracks at a given annealing time. PMID:29068408

Emotion self-regulation and empathy depend upon longer stimulus exposure.

PubMed

Ikezawa, Satoru; Corbera, Silvia; Wexler, Bruce E

2014-10-01

Observation of others in pain induces positive elevation (pain effect) in late event-related potentials (ERP). This effect is associated with top-down attention regulating processes. It has previously been shown that stimulus exposure duration can affect top-down attentional modulation of response to threat-related stimuli. We investigated the effect of exposure duration on ERP response to others in pain. Two late ERP components, P3 and late positive potentials (LPP), from 18 healthy people were measured while they viewed pictures of hands in painful or neutral situations for either 200 or 500 ms, during two task conditions (pain judgment and counting hands). P3 and LPP pain effects during the pain judgment condition were significantly greater with 500 ms than 200 ms stimulus presentation. Ours is the first study to suggest that engagement of empathy-related self-regulatory processes reflected in late potentials requires longer exposure to the pain-related stimulus. Although this is important information about the relationship between early sensory and subsequent brain processing, and about engagement of self-regulatory processes, the neural basis of this time-dependence remains unclear. It might be important to investigate the relationship between stimulus duration and empathic response in clinical populations where issues of self-regulation, empathic response and speed of information processing exist. © The Author (2013). Published by Oxford University Press. For Permissions, please email: journals.permissions@oup.com.

Microbiological and physicochemical characterization of dry-cured Halal goat meat. Effect of salting time and addition of olive oil and paprika covering.

PubMed

Cherroud, Sanâa; Cachaldora, Aida; Fonseca, Sonia; Laglaoui, Amin; Carballo, Javier; Franco, Inmaculada

2014-10-01

The objective of this work was to define a simple technological process for dry-cured Halal goat meat elaboration. The aims of this study were to analyze physicochemical parameters and to enumerate the microbial population at the end of the different manufacturing processes (two salting times and the addition of olive oil and paprika covering) on 36 units of meat product. A total of 532 strains were isolated from several selective culture media and then identified using classical and molecular methods. In general, salt effect and the addition of olive oil and paprika were significant for all the studied microbial groups as well as on NaCl content and water activity. Molecular analysis proves that staphylococci, especially Staphylococcus xylosus and Staphylococcus equorum, were the most common naturally occurring microbiota. The best manufacturing process would be obtained with a longer salting time and the addition of the olive oil and paprika covering. Copyright © 2014 Elsevier Ltd. All rights reserved.

Building a Bridge to Deep Time: Sedimentary Systems Across Timescales

NASA Astrophysics Data System (ADS)

Romans, B.; Castelltort, S.; Covault, J. A.; Walsh, J. P.

2013-12-01

It is increasingly important to understand the complex and interdependent processes associated with sediment production, transport, and deposition at timescales relevant to civilization (annual to millennial). However, predicting the response of sedimentary systems to global environmental change across a range of timescales remains a significant challenge. For example, a significant increase in global average temperature at the Paleocene-Eocene boundary (55.8 Ma) is interpreted to have occurred over millennial timescales; however, the specific response of sedimentary systems (e.g., timing and magnitude of sediment flux variability in river systems) to that forcing is debated. Thus, using such environmental perturbations recorded in sedimentary archives as analogs for ongoing/future global change requires improved approaches to bridging across time. Additionally, the ability to bridge timescales is critical for addressing other questions about sedimentary system behavior, including signal propagation and signal versus ';noise' in the record. The geologic record provides information that can be used to develop a comprehensive understanding of process-response behavior at multiple timescales. The geomorphic ';snapshot' of present-day erosional and depositional landscapes can be examined to reconstruct the history of processes that created the observable configurations. Direct measurement and monitoring of active processes are used to constrain conceptual and numerical models and develop sedimentary system theory. But real-time observations of active Earth-surface processes are limited to the very recent, and how such processes integrate over longer timescales to transform into strata remains unknown. At longer timescales (>106 yr), the stratigraphic record is the only vestige of ancient sedimentary systems. Stratigraphic successions contain a complex record of sediment deposition and preservation, as well as the detrital material that originated in long since denuded orogenic belts. Moreover, as the timescale of the duration of the process-response behavior and/or system age increase, additional aspects must be considered (e.g., significant tectonic regime change, rare but significant events, non-periodic global change, etc.). In this presentation we discuss several examples of sedimentary system analysis at different timescales with the goal of highlighting various approaches at one timescale and how they can (or cannot) be applied for questions at different timescales. Examples include: (1) brief review of decadal to centennial sediment budgets; (2) land-to-sea sediment budget reconstructions from southern California at millennial to multi-millennial timescales, and (3) sedimentary system response to climatic and tectonic forcings at ≥105 yr timescales.

Relationships between plate convergence, the earthquake cycle, and long-term accumulation of net tectonic deformation at island arcs; not so simple as it seems

NASA Astrophysics Data System (ADS)

Taylor, F. W.; Lavier, L. L.; Bevis, M. G.; Thirumalai, K.; Frohlich, C. A.

2012-12-01

Over million-year time scales, what is the relationship between the meter-scale vertical displacements that occur in individual large subduction-zone earthquakes, and the observed topography and geology of island arcs? Because the geographic distribution of vertical displacements associated with the earthquake cycle sometimes mimics topography, it is tempting to assume that vertical deformation simply accrues as the coseismic part of the cycle that is preserved from one event to another. However, our research in the Central New Hebrides and Western Solomon arcs demonstrates that truly permanent tectonic deformation is a step farther removed from the earthquake cycle than we originally assumed. By precisely dating of coral reef terraces we are able to evaluate vertical deformation over time scales of 10,000 to 100,000 years. This analysis indicates that these arcs undergo episodes of hundreds of meters of subsidence and uplift over time scales of tens of thousands of years. Thus what remains in the geologic record is potentially providing invaluable information about more fundamental processes than the elastic earthquake cycle. These longer-term episodes of vertical motion may act in many arcs throughout the world, but evidence of them may be poorly preserved outside of tropical regions where corals along island coastlines provide a record of their occurrence.In our presentation we will describe the tectonic behavior observed in the Central New Hebrides and Western Solomons. We will speculate about some possible mechanisms that explain how the subduction process generates longer-term episodes of subsidence and uplift, and make suggestions about future observations that could better constrain the nature of these processes.

Sex Differences in Time to Return-to-Play Progression After Sport-Related Concussion.

PubMed

Stone, Sarah; Lee, Bobby; Garrison, J Craig; Blueitt, Damond; Creed, Kalyssa

2016-10-03

Recently, female sports participation has increased, and there is a tendency for women to experience more symptoms and variable presentation after sport-related concussion (SRC). The purpose of this study was to determine whether sex differences exist in time to begin a return-to-play (RTP) progression after an initial SRC. After initial SRC, female athletes (11-20 years old) would take longer to begin an RTP progression compared with age-matched male athletes. Retrospective cohort study. Level 3. A total of 579 participants (365 males [mean age, 15.0 ± 1.7 years], 214 females [mean age, 15.2 ± 1.5 years]), including middle school, high school, and collegiate athletes who participated in various sports and experienced an initial SRC were included and underwent retrospective chart review. The following information was collected: sex, age at injury, sport, history of prior concussion, date of injury, and date of initiation of RTP progression. Participants with a history of more than 1 concussion or injury sustained from non-sport-related activity were excluded. Despite American football having the greatest percentage (49.2%) of sport participation, female athletes took significantly longer to start an RTP progression after an initial SRC (29.1 ± 26.3 days) compared with age-matched male athletes (22.7 ± 18.3 days; P = 0.002). On average, female athletes took approximately 6 days longer to begin an RTP progression compared with age-matched male athletes. This suggests that sex differences exist between athletes, ages 11 to 20 years, with regard to initiation of an RTP progression after SRC. Female athletes may take longer to recover after an SRC, and therefore, may take longer to return to sport. Sex should be considered as part of the clinical decision-making process when determining plan of care for this population. © 2016 The Author(s).

The effect of hubs and shortcuts on fixation time in evolutionary graphs

NASA Astrophysics Data System (ADS)

Askari, Marziyeh; Moradi Miraghaei, Zeinab; Aghababaei Samani, Keivan

2017-07-01

How can a new species (like a gene, an idea, or a strategy) take over the whole of a population? This process, which is called fixation, is considerably affected by the structure of the population. There are two key quantities to quantify the fixation process, namely fixation probability and fixation time. Fixation probability has been vastly studied in recent years, but fixation time has not been completely explored, yet. This is because the discovery of a relationship between fixation time and network structure is quite challenging. In this paper we investigate this relationship for a number of well-known complex networks. We show that the existence of a few high-degree nodes (hubs) in the network results in a longer fixation time, while the existence of a few short-cuts decreases the fixation time. Furthermore we investigate the effect of network parameters, such as connection probability, on fixation time. We show that by increasing the density of edges, fixation time decreases for all types of studied networks. Finally, we survey the effect of rewiring probability in a Watts-Strogatz network on fixation time.

Phased Array Feeds

NASA Astrophysics Data System (ADS)

Fisher, J. Richard; Bradley, Richard F.; Brisken, Walter F.; Cotton, William D.; Emerson, Darrel T.; Kerr, Anthony R.; Lacasse, Richard J.; Morgan, Matthew A.; Napier, Peter J.; Norrod, Roger D.; Payne, John M.; Pospieszalski, Marian W.; Symmes, Arthur; Thompson, A. Richard; Webber, John C.

2009-03-01

This white paper offers cautionary observations about the planning and development of new, large radio astronomy instruments. Complexity is a strong cost driver so every effort should be made to assign differing science requirements to different instruments and probably different sites. The appeal of shared resources is generally not realized in practice and can often be counterproductive. Instrument optimization is much more difficult with longer lists of requirements, and the development process is longer and less efficient. More complex instruments are necessarily further behind the technology state of the art because of longer development times. Including technology R&D in the construction phase of projects is a growing trend that leads to higher risks, cost overruns, schedule delays, and project de-scoping. There are no technology breakthroughs just over the horizon that will suddenly bring down the cost of collecting area. Advances come largely through careful attention to detail in the adoption of new technology provided by industry and the commercial market. Radio astronomy instrumentation has a very bright future, but a vigorous long-term R&D program not tied directly to specific projects needs to be restored, fostered, and preserved.

Large Instrument Development for Radio Astronomy

NASA Astrophysics Data System (ADS)

Fisher, J. Richard; Warnick, Karl F.; Jeffs, Brian D.; Norrod, Roger D.; Lockman, Felix J.; Cordes, James M.; Giovanelli, Riccardo

2009-03-01

This white paper offers cautionary observations about the planning and development of new, large radio astronomy instruments. Complexity is a strong cost driver so every effort should be made to assign differing science requirements to different instruments and probably different sites. The appeal of shared resources is generally not realized in practice and can often be counterproductive. Instrument optimization is much more difficult with longer lists of requirements, and the development process is longer and less efficient. More complex instruments are necessarily further behind the technology state of the art because of longer development times. Including technology R&D in the construction phase of projects is a growing trend that leads to higher risks, cost overruns, schedule delays, and project de-scoping. There are no technology breakthroughs just over the horizon that will suddenly bring down the cost of collecting area. Advances come largely through careful attention to detail in the adoption of new technology provided by industry and the commercial market. Radio astronomy instrumentation has a very bright future, but a vigorous long-term R&D program not tied directly to specific projects needs to be restored, fostered, and preserved.

Inferring difficulty: Flexibility in the real-time processing of disfluency

PubMed Central

Heller, Daphna; Arnold, Jennifer E.; Klein, Natalie M.; Tanenhaus, Michael K.

2015-01-01

Upon hearing a disfluent referring expression, listeners expect the speaker to refer to an object that is previously-unmentioned, an object that does not have a straightforward label, or an object that requires a longer description. Two visual-world eye-tracking experiments examined whether listeners directly associate disfluency with these properties of objects, or whether disfluency attribution is more flexible and involves situation-specific inferences. Since in natural situations reference to objects that do not have a straightforward label or that require a longer description is correlated with both production difficulty and with disfluency, we used a mini artificial lexicon to dissociate difficulty from these properties, building on the fact that recently-learned names take longer to produce than existing words in one’s mental lexicon. The results demonstrate that disfluency attribution involves situation-specific inferences; we propose that in new situations listeners spontaneously infer what may cause production difficulty. However, the results show that these situation-specific inferences are limited in scope: listeners assessed difficulty relative to their own experience with the artificial names, and did not adapt to the assumed knowledge of the speaker. PMID:26677642

Retrofit concept for small safety related stationary machines

NASA Astrophysics Data System (ADS)

Epple, S.; Jalba, C. K.; Muminovic, A.; Jung, R.

2017-05-01

More and more old machines have the problem that their control electronics’ lifecycle comes to its intended end of life, whilst the mechanics itself and process capability is still in very good condition. This article shows an example of a reactive ion etcher originally built in 1988, which was refitted with a new control concept. The original control unit was repaired several times based on manufacturer’s obsolescence management. At start of the retrofit project the integrated circuits were no longer available for further repair of the original control unit. Safety, repeatability and stability of the process were greatly improved.

Sex and personality traits influence the difference between time taken to tell the truth or lie.

PubMed

Farrow, Tom F D; Reilly, Rebecca; Rahman, Towhida A; Herford, Amy E; Woodruff, Peter W R; Spence, Sean A

2003-10-01

A necessary component of lying is the withholding of a truthful response. Hence, lying may be conceptualised as involving the inhibition of an initial, automatic response (the truth) while an alternative response (the lie) is generated. We investigated response times to visually and auditorially presented questions probing recent episodic memory, when subjects answered questions truthfully or with lies. We also investigated whether the absolute response times or difference between time taken to tell the truth or lie was affected by participants' sex or correlated with personality scores on the Eysenck Personality Questionnaire Revised-Short Scale. 61 subjects answered the same 36 questions five times. The first time involved answering all questions truthfully, which allowed post hoc analysis of whether subjects had been consistent in their lying and truth-telling on the following four occasions. These latter four occasions involved answering all questions (one each with 'truth' or 'lie') for both types of presentation. Regardless of type of presentation or subjects' sex, subjects took approximately 200 msec. longer to lie than to tell the truth in response to each question (p<.001). There were significant correlations between truthful response times to auditorially presented questions and Eysenck 'Neuroticism' scores. There was also a significant correlation for women between mean individual lie-minus-truth time to auditorially presented questions and Eysenck 'Lie' scores. These preliminary data suggest that response time is systematically longer when telling a lie and that personality variables may play a part in this process.

Exploring if day and time of admission is associated with average length of stay among inpatients from a tertiary hospital in Singapore: an analytic study based on routine admission data.

PubMed

Earnest, Arul; Chen, Mark I C; Seow, Eillyne

2006-01-22

It has been postulated that patients admitted on weekends or after office hours may experience delays in clinical management and consequently have longer length of stay (LOS). We investigated if day and time of admission is associated with LOS in Tan Tock Seng Hospital (TTSH), a 1,400 bed acute care tertiary hospital serving the central and northern regions of Singapore. This was a historical cohort study based on all admissions from TTSH from 1st September 2003 to 31st August 2004. Data was extracted from routinely available computerized hospital information systems for analysis by episode of care. LOS for each episode of care was log-transformed before analysis, and a multivariate linear regression model was used to study if sex, age group, type of admission, admission source, day of week admitted, admission on a public holiday or eve of public holiday, admission on a weekend and admission time were associated with an increased LOS. In the multivariate analysis, sex, age group, type of admission, source of admission, admission on the eve of public holiday and weekends and time of day admitted were independently and significantly associated with LOS. Patients admitted on Friday, Saturday or Sunday stayed on average 0.3 days longer than those admitted on weekdays, after adjusting for potential confounders; those admitted on the eve of public holidays, and those admitted in the afternoons and after office hours also had a longer LOS (differences of 0.71, 1.14 and 0.65 days respectively). Cases admitted over a weekend, eve of holiday, in the afternoons, and after office hours, do have an increased LOS. Further research is needed to identify processes contributing to the above phenomenon.

[Lymphoscintigrams with anatomical landmarks obtained with vector graphics].

PubMed

Rubini, Giuseppe; Antonica, Filippo; Renna, Maria Antonia; Ferrari, Cristina; Iuele, Francesca; Stabile Ianora, Antonio Amato; Losco, Matteo; Niccoli Asabella, Artor

2012-11-01

Nuclear medicine images are difficult to interpret because they do not include anatomical details. The aim of this study was to obtain lymphoscintigrams with anatomical landmarks that could be easily interpreted by General Physicians. Traditional lymphoscintigrams were processed with Adobe© Photoshop® CS6 and converted into vector images created by Illustrator®. The combination with a silhouette vector improved image interpretation, without resulting in longer radiation exposure or acquisition times.

Zero Nuclear Weapons and Nuclear Security Enterprise Modernization

DTIC Science & Technology

2011-01-01

national security strategy. For the first time since the Manhattan Project , the United States was no longer building nuclear weapons and was in fact...50 to 60 years to the Manhattan Project and are on the verge of catastrophic failure. Caustic chemicals and processes have sped up the corrosion and...day, the United States must fund the long-term modernization effort of the entire enter­ prise. Notes 1. Nuclear Weapon Archive, “The Manhattan

Are Experienced Hearing Aid Users Faster at Grasping the Meaning of a Sentence Than Inexperienced Users? An Eye-Tracking Study

PubMed Central

Kollmeier, Birger; Neher, Tobias

2016-01-01

This study assessed the effects of hearing aid (HA) experience on how quickly a participant can grasp the meaning of an acoustic sentence-in-noise stimulus presented together with two similar pictures that either correctly (target) or incorrectly (competitor) depict the meaning conveyed by the sentence. Using an eye tracker, the time taken by the participant to start fixating the target (the processing time) was measured for two levels of linguistic complexity (low vs. high) and three HA conditions: clinical linear amplification (National Acoustic Laboratories-Revised), single-microphone noise reduction with National Acoustic Laboratories-Revised, and linear amplification ensuring a sensation level of ≥ 15 dB up to at least 4 kHz for the speech material used here. Timed button presses to the target stimuli after the end of the sentences (offline reaction times) were also collected. Groups of experienced (eHA) and inexperienced (iHA) HA users matched in terms of age, hearing loss, and working memory capacity took part (N = 15 each). For the offline reaction times, no effects were found. In contrast, processing times increased with linguistic complexity. Furthermore, for all HA conditions, processing times were longer (poorer) for the iHA group than for the eHA group, despite comparable speech recognition performance. Taken together, these results indicate that processing times are more sensitive to speech processing-related factors than offline reaction times. Furthermore, they support the idea that HA experience positively impacts the ability to process noisy speech quickly, irrespective of the precise gain characteristics. PMID:27595793

Role of syn-eruptive plagioclase disequilibrium crystallization in basaltic magma ascent dynamics.

PubMed

La Spina, G; Burton, M; De' Michieli Vitturi, M; Arzilli, F

2016-12-12

Timescales of magma ascent in conduit models are typically assumed to be much longer than crystallization and gas exsolution for basaltic eruptions. However, it is now recognized that basaltic magmas may rise fast enough for disequilibrium processes to play a key role on the ascent dynamics. The quantification of the characteristic times for crystallization and exsolution processes are fundamental to our understanding of such disequilibria and ascent dynamics. Here we use observations from Mount Etna's 2001 eruption and a magma ascent model to constrain timescales for crystallization and exsolution processes. Our results show that plagioclase reaches equilibrium in 1-2 h, whereas ascent times were <1 h. Using these new constraints on disequilibrium plagioclase crystallization we also reproduce observed crystal abundances for different basaltic eruptions. The strong relation between magma ascent rate and disequilibrium crystallization and exsolution plays a key role in controlling eruption dynamics in basaltic volcanism.

Role of syn-eruptive plagioclase disequilibrium crystallization in basaltic magma ascent dynamics

PubMed Central

La Spina, G.; Burton, M.; de' Michieli Vitturi, M.; Arzilli, F.

2016-01-01

Timescales of magma ascent in conduit models are typically assumed to be much longer than crystallization and gas exsolution for basaltic eruptions. However, it is now recognized that basaltic magmas may rise fast enough for disequilibrium processes to play a key role on the ascent dynamics. The quantification of the characteristic times for crystallization and exsolution processes are fundamental to our understanding of such disequilibria and ascent dynamics. Here we use observations from Mount Etna's 2001 eruption and a magma ascent model to constrain timescales for crystallization and exsolution processes. Our results show that plagioclase reaches equilibrium in 1–2 h, whereas ascent times were <1 h. Using these new constraints on disequilibrium plagioclase crystallization we also reproduce observed crystal abundances for different basaltic eruptions. The strong relation between magma ascent rate and disequilibrium crystallization and exsolution plays a key role in controlling eruption dynamics in basaltic volcanism. PMID:27941750

Transport time and care processes for patients transferred with ST-segment-elevation myocardial infarction: the reperfusion in acute myocardial infarction in Carolina emergency rooms experience.

PubMed

Muñoz, Daniel; Roettig, Mayme L; Monk, Lisa; Al-Khalidi, Hussein; Jollis, James G; Granger, Christopher B

2012-08-01

For patients with ST-segment elevation myocardial infarction transferred for primary percutaneous coronary intervention, guidelines have called for device activation within 90 minutes of initial presentation. Fewer than 20% of transferred patients are treated in such a timely fashion. We examine the association between transfer drive times and door-to-device (D2D) times in a network of North Carolina hospitals. We compare the feasibility of timely percutaneous coronary intervention using ground versus air transfer. We perform a retrospective analysis of the relationship between transfer drive times and D2D times in a 119-hospital ST-segment-elevation myocardial infarction statewide network. Between July 2008 and December 2009, 1537 ST-segment-elevation myocardial infarction patients underwent interhospital transfer for reperfusion via primary percutaneous coronary intervention. For ground transfers, median D2D time was 93 minutes for drive times ≤30 minutes, 117 minutes for drive times of 31 to 45 minutes, and 121 minutes for drive times >45 minutes. For air transfers, median D2D time was 125 minutes for drive times of 31 to 45 minutes and 138 minutes for drive times >45 minutes. Helicopter transport was associated with longer door-in door-out times and, ultimately, was associated with median D2D times that exceeded guideline recommendations, no matter the transfer drive time category. In a well-developed ST-segment-elevation myocardial infarction system, D2D times within 90 to 120 minutes appear most feasible for hospitals within 30-minute transfer drive time. Helicopter transport did not offer D2D time advantages for transferred STEMI patients. This finding appears to be attributable to comparably longer door-in door-out times for air transfers.

Watch what you type: the role of visual feedback from the screen and hands in skilled typewriting.

PubMed

Snyder, Kristy M; Logan, Gordon D; Yamaguchi, Motonori

2015-01-01

Skilled typing is controlled by two hierarchically structured processing loops (Logan & Crump, 2011): The outer loop, which produces words, commands the inner loop, which produces keystrokes. Here, we assessed the interplay between the two loops by investigating how visual feedback from the screen (responses either were or were not echoed on the screen) and the hands (the hands either were or were not covered with a box) influences the control of skilled typing. Our results indicated, first, that the reaction time of the first keystroke was longer when responses were not echoed than when they were. Also, the interkeystroke interval (IKSI) was longer when the hands were covered than when they were visible, and the IKSI for responses that were not echoed was longer when explicit error monitoring was required (Exp. 2) than when it was not required (Exp. 1). Finally, explicit error monitoring was more accurate when response echoes were present than when they were absent, and implicit error monitoring (i.e., posterror slowing) was not influenced by visual feedback from the screen or the hands. These findings suggest that the outer loop adjusts the inner-loop timing parameters to compensate for reductions in visual feedback. We suggest that these adjustments are preemptive control strategies designed to execute keystrokes more cautiously when visual feedback from the hands is absent, to generate more cautious motor programs when visual feedback from the screen is absent, and to enable enough time for the outer loop to monitor keystrokes when visual feedback from the screen is absent and explicit error reports are required.

Protected quantum computing: interleaving gate operations with dynamical decoupling sequences.

PubMed

Zhang, Jingfu; Souza, Alexandre M; Brandao, Frederico Dias; Suter, Dieter

2014-02-07

Implementing precise operations on quantum systems is one of the biggest challenges for building quantum devices in a noisy environment. Dynamical decoupling attenuates the destructive effect of the environmental noise, but so far, it has been used primarily in the context of quantum memories. Here, we experimentally demonstrate a general scheme for combining dynamical decoupling with quantum logical gate operations using the example of an electron-spin qubit of a single nitrogen-vacancy center in diamond. We achieve process fidelities >98% for gate times that are 2 orders of magnitude longer than the unprotected dephasing time T2.

Hyperscanning and avoidance in social anxiety disorder: the visual scanpath during public speaking.

PubMed

Chen, Nigel Teik Ming; Thomas, Laurenn Maree; Clarke, Patrick Joseph Fraser; Hickie, Ian Bernard; Guastella, Adam John

2015-02-28

Social anxiety disorder (SAD) is a debilitating mental illness which is thought to be maintained in part by the aberrant attentional processing of socially relevant information. Critically however, research has not assessed whether such aberrant attentional processing occurs during social-evaluative contexts characteristically feared in SAD. The current study presents a novel approach for the assessment of the visuocognitive biases operating in SAD during a social-evaluative stressor. For this task, clinically socially anxious participants and controls were required to give a brief impromptu speech in front of a pre-recorded audience who intermittently displayed socially positive or threatening gestures. Participant gaze at the audience display was recorded throughout the speech. Socially anxious participants exhibited a significantly longer visual scanpath, relative to controls. In addition, socially anxious participants spent relatively longer time fixating at the non-social regions in between and around the confederates. The findings of the present study suggest that SAD is associated with hyperscanning and the attentional avoidance of social stimuli. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Accuracy and time requirements of a bar-code inventory system for medical supplies.

PubMed

Hanson, L B; Weinswig, M H; De Muth, J E

1988-02-01

The effects of implementing a bar-code system for issuing medical supplies to nursing units at a university teaching hospital were evaluated. Data on the time required to issue medical supplies to three nursing units at a 480-bed, tertiary-care teaching hospital were collected (1) before the bar-code system was implemented (i.e., when the manual system was in use), (2) one month after implementation, and (3) four months after implementation. At the same times, the accuracy of the central supply perpetual inventory was monitored using 15 selected items. One-way analysis of variance tests were done to determine any significant differences between the bar-code and manual systems. Using the bar-code system took longer than using the manual system because of a significant difference in the time required for order entry into the computer. Multiple-use requirements of the central supply computer system made entering bar-code data a much slower process. There was, however, a significant improvement in the accuracy of the perpetual inventory. Using the bar-code system for issuing medical supplies to the nursing units takes longer than using the manual system. However, the accuracy of the perpetual inventory was significantly improved with the implementation of the bar-code system.

Child and family-related predictors of psychological outcomes in children adopted from abroad; what is the role of caregiver time?

PubMed

Rita, Niina; Elovainio, Marko; Raaska, Hanna; Lahti-Nuuttila, Pekka; Matomäki, Jaakko; Sinkkonen, Jari; Lapinleimu, Helena

2017-08-01

International adoptees need to cope with stressful transitions and to develop secure attachment with their caregivers at the same time. Although most children adopted from abroad adjust fine, they are at increased risk of psychological problems. We investigated whether both child and family-related factors are associated with later psychological problems and whether the length of time spent at home after adoption before daycare moderates these associations among internationally adopted children in Finland (FinAdo, Finnish Adoption Study). The sample consisted of 1,265 children (708 girls, 557 boys) who arrived in Finland before they started school (mean age 2 years at arrival). Later behavioral problems were measured using the Child Behavior Check List (CBCL). According to our results, male gender, older age, child's early clinical symptoms (problems of sensory processing) and single parenthood were associated with later behavioral problems measured by CBCL scores. Longer stay at home before the start of daycare or school modified these results. Longer stay at home was associated with less later behavioral externalizing problems in girls but not in boys compared to those who spent a shorter time at home. © 2017 Scandinavian Psychological Associations and John Wiley & Sons Ltd.

Individual differences in non-symbolic numerical abilities predict mathematical achievements but contradict ATOM.

PubMed

Agrillo, Christian; Piffer, Laura; Adriano, Andrea

2013-07-01

A significant debate surrounds the nature of the cognitive mechanisms involved in non-symbolic number estimation. Several studies have suggested the existence of the same cognitive system for estimation of time, space, and number, called "a theory of magnitude" (ATOM). In addition, researchers have proposed the theory that non-symbolic number abilities might support our mathematical skills. Despite the large number of studies carried out, no firm conclusions can be drawn on either topic. In the present study, we correlated the performance of adults on non-symbolic magnitude estimations and symbolic numerical tasks. Non-symbolic magnitude abilities were assessed by asking participants to estimate which auditory tone lasted longer (time), which line was longer (space), and which group of dots was more numerous (number). To assess symbolic numerical abilities, participants were required to perform mental calculations and mathematical reasoning. We found a positive correlation between non-symbolic and symbolic numerical abilities. On the other hand, no correlation was found among non-symbolic estimations of time, space, and number. Our study supports the idea that mathematical abilities rely on rudimentary numerical skills that predate verbal language. By contrast, the lack of correlation among non-symbolic estimations of time, space, and number is incompatible with the idea that these magnitudes are entirely processed by the same cognitive system.

Critical reflexivity in financial markets: a Hawkes process analysis

NASA Astrophysics Data System (ADS)

Hardiman, Stephen J.; Bercot, Nicolas; Bouchaud, Jean-Philippe

2013-10-01

We model the arrival of mid-price changes in the E-mini S&P futures contract as a self-exciting Hawkes process. Using several estimation methods, we find that the Hawkes kernel is power-law with a decay exponent close to -1.15 at short times, less than ≈ 103 s, and crosses over to a second power-law regime with a larger decay exponent ≈-1.45 for longer times scales in the range [ 103,106 ] seconds. More importantly, we find that the Hawkes kernel integrates to unity independently of the analysed period, from 1998 to 2011. This suggests that markets are and have always been close to criticality, challenging a recent study which indicates that reflexivity (endogeneity) has increased in recent years as a result of increased automation of trading. However, we note that the scale over which market events are correlated has decreased steadily over time with the emergence of higher frequency trading.

Transient establishment of the wavefronts for negative, zero, and positive refraction.

PubMed

Zhao, Wenjuan; Wu, Qiang; Wang, Ride; Gao, Jianshun; Lu, Yao; Zhang, Qi; Qi, Jiwei; Zhang, Chunling; Pan, Chongpei; Rupp, Romano; Xu, Jingjun

2018-01-22

We quantitatively demonstrate transient establishment of wavefronts for negative, zero, and positive refraction through a wedge-shaped metamaterial consisting of periodically arranged split-ring resonators and metallic wires. The wavefronts for the three types of refractions propagate through the second interface of the wedge along positive refraction angles at first, then reorganize, and finally propagate along the effective refraction angles after a period of establishment time respectively. The establishment time of the wavefronts prevents violating causality or superluminal propagation for negative and zero refraction. The establishment time for negative or zero refraction is longer than that for positive refraction. For all three refraction processes, transient establishment processes precede the establishment of steady propagation. Moreover, some detailed characters are proven in our research, including infinite wavelength, uniform phase inside the zero-index material, and the phase velocity being antiparallel to the group velocity in the negative-index material.

Remediation of sandy soils contaminated with hydrocarbons and halogenated hydrocarbons by soil vapour extraction.

PubMed

Albergaria, José Tomás; Alvim-Ferraz, Maria da Conceição M; Delerue-Matos, Cristina

2012-08-15

This paper presents the study of the remediation of sandy soils containing six of the most common contaminants (benzene, toluene, ethylbenzene, xylene, trichloroethylene and perchloroethylene) using soil vapour extraction (SVE). The influence of soil water content on the process efficiency was evaluated considering the soil type and the contaminant. For artificially contaminated soils with negligible clay contents and natural organic matter it was concluded that: (i) all the remediation processes presented efficiencies above 92%; (ii) an increase of the soil water content led to a more time-consuming remediation; (iii) longer remediation periods were observed for contaminants with lower vapour pressures and lower water solubilities due to mass transfer limitations. Based on these results an easy and relatively fast procedure was developed for the prediction of the remediation times of real soils; 83% of the remediation times were predicted with relative deviations below 14%. Copyright © 2012 Elsevier Ltd. All rights reserved.

Can correlations among receptors affect the information about the stimulus?

NASA Astrophysics Data System (ADS)

Singh, Vijay; Tchernookov, Martin; Nemenman, Ilya

2014-03-01

In the context of neural information processing, it has been observed that, compared to the case of independent receptors, correlated receptors can often carry more information about the stimulus. We explore similar ideas in the context of molecular information processing, analyzing a cell with receptors whose activity is intrinsically negatively correlated because they compete for the same ligand molecules. We show analytically that, in case the involved biochemical interactions are linear, the information between the number of molecules captured by the receptors and the ligand concentration does not depend on correlations among the receptors. For a nonlinear kinetic network, correlations similarly do not change the amount of information for observation times much shorter or much longer than the characteristic time scale of ligand molecule binding and unbinding. However, at intermediate times, correlations can increase the amount of available information. This work has been supported by the James S McDonnell foundation.

Information processing capacity in psychopathy: Effects of anomalous attention.

PubMed

Hamilton, Rachel K B; Newman, Joseph P

2018-03-01

Hamilton and colleagues (2015) recently proposed that an integrative deficit in psychopathy restricts simultaneous processing, thereby leaving fewer resources available for information encoding, narrowing the scope of attention, and undermining associative processing. The current study evaluated this parallel processing deficit proposal using the Simultaneous-Sequential paradigm. This investigation marks the first a priori test of the Hamilton et al.'s theoretical framework. We predicted that psychopathy would be associated with inferior performance (as indexed by lower accuracy and longer response time) on trials requiring simultaneous processing of visual information relative to trials necessitating sequential processing. Results were consistent with these predictions, supporting the proposal that psychopathy is characterized by a reduced capacity to process multicomponent perceptual information concurrently. We discuss the potential implications of impaired simultaneous processing for the conceptualization of the psychopathic deficit. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

Histological preparation of developing vestibular otoconia for scanning electron microscopy

NASA Technical Reports Server (NTRS)

Huss, D.; Dickman, J. D.

2003-01-01

The unique nature of vestibular otoconia as calcium carbonate biominerals makes them particularly susceptible to chemical deformation during histological processing. We fixed and stored otoconia from all three otolith endorgans of embryonic, hatchling and adult Japanese quail in glutaraldehyde containing either phosphate or non-phosphate buffers for varying lengths of time and processed them for scanning electron microscopy. Otoconia from all age groups and otolith endorgans processed in 0.1 M phosphate buffer (pH 7.4) showed abnormal surface morphology when compared to acetone fixed controls. Otoconia processed in 0.1 M sodium cacodylate or HEPES buffered artificial endolymph (pH 7.4) showed normal morphology that was similar to controls. The degree of otoconial deformation was directly related to the time exposed to phosphate buffer. Short duration exposure produced particulate deformations while longer exposures resulted in fused otoconia that formed solid sheets. Otoconial surface deformation and fusing was independent of the glutaraldehyde component of the histological processing. These findings should help vestibular researchers to develop appropriate histological processing protocols in future studies of otoconia.

Electrophysiological evidence for parallel and serial processing during visual search.

PubMed

Luck, S J; Hillyard, S A

1990-12-01

Event-related potentials were recorded from young adults during a visual search task in order to evaluate parallel and serial models of visual processing in the context of Treisman's feature integration theory. Parallel and serial search strategies were produced by the use of feature-present and feature-absent targets, respectively. In the feature-absent condition, the slopes of the functions relating reaction time and latency of the P3 component to set size were essentially identical, indicating that the longer reaction times observed for larger set sizes can be accounted for solely by changes in stimulus identification and classification time, rather than changes in post-perceptual processing stages. In addition, the amplitude of the P3 wave on target-present trials in this condition increased with set size and was greater when the preceding trial contained a target, whereas P3 activity was minimal on target-absent trials. These effects are consistent with the serial self-terminating search model and appear to contradict parallel processing accounts of attention-demanding visual search performance, at least for a subset of search paradigms. Differences in ERP scalp distributions further suggested that different physiological processes are utilized for the detection of feature presence and absence.

Objectively-measured impulsivity and attention-deficit/hyperactivity disorder (ADHD): testing competing predictions from the working memory and behavioral inhibition models of ADHD.

PubMed

Raiker, Joseph S; Rapport, Mark D; Kofler, Michael J; Sarver, Dustin E

2012-07-01

Impulsivity is a hallmark of two of the three DSM-IV ADHD subtypes and is associated with myriad adverse outcomes. Limited research, however, is available concerning the mechanisms and processes that contribute to impulsive responding by children with ADHD. The current study tested predictions from two competing models of ADHD-working memory (WM) and behavioral inhibition (BI)-to examine the extent to which ADHD-related impulsive responding was attributable to model-specific mechanisms and processes. Children with ADHD (n = 21) and typically developing children (n = 20) completed laboratory tasks that provided WM (domain-general central executive [CE], phonological/visuospatial storage/rehearsal) and BI indices (stop-signal reaction time [SSRT], stop-signal delay, mean reaction time). These indices were examined as potential mediators of ADHD-related impulsive responding on two objective and diverse laboratory tasks used commonly to assess impulsive responding (CPT: continuous performance test; VMTS: visual match-to-sample). Bias-corrected, bootstrapped mediation analyses revealed that CE processes significantly attenuated between-group impulsivity differences, such that the initial large-magnitude impulsivity differences were no longer significant on either task after accounting for ADHD-related CE deficits. In contrast, SSRT partially mediated ADHD-related impulsive responding on the CPT but not VMTS. This partial attenuation was no longer significant after accounting for shared variance between CE and SSRT; CE continued to attenuate the ADHD-impulsivity relationship after accounting for SSRT. These findings add to the growing literature implicating CE deficits in core ADHD behavioral and functional impairments, and suggest that cognitive interventions targeting CE rather than storage/rehearsal or BI processes may hold greater promise for alleviating ADHD-related impairments.

Relationship between slow visual processing and reading speed in people with macular degeneration

PubMed Central

Cheong, Allen MY; Legge, Gordon E; Lawrence, Mary G; Cheung, Sing-Hang; Ruff, Mary A

2007-01-01

Purpose People with macular degeneration (MD) often read slowly even with adequate magnification to compensate for acuity loss. Oculomotor deficits may affect reading in MD, but cannot fully explain the substantial reduction in reading speed. Central-field loss (CFL) is often a consequence of macular degeneration, necessitating the use of peripheral vision for reading. We hypothesized that slower temporal processing of visual patterns in peripheral vision is a factor contributing to slow reading performance in MD patients. Methods Fifteen subjects with MD, including 12 with CFL, and five age-matched control subjects were recruited. Maximum reading speed and critical print size were measured with RSVP (Rapid Serial Visual Presentation). Temporal processing speed was studied by measuring letter-recognition accuracy for strings of three randomly selected letters centered at fixation for a range of exposure times. Temporal threshold was defined as the exposure time yielding 80% recognition accuracy for the central letter. Results Temporal thresholds for the MD subjects ranged from 159 to 5881 ms, much longer than values for age-matched controls in central vision (13 ms, p<0.01). The mean temporal threshold for the 11 MD subjects who used eccentric fixation (1555.8 ± 1708.4 ms) was much longer than the mean temporal threshold (97.0 ms ± 34.2 ms, p<0.01) for the age-matched controls at 10° in the lower visual field. Individual temporal thresholds accounted for 30% of the variance in reading speed (p<0.05). Conclusion The significant association between increased temporal threshold for letter recognition and reduced reading speed is consistent with the hypothesis that slower visual processing of letter recognition is one of the factors limiting reading speed in MD subjects. PMID:17881032

Signatures of hypermassive neutron star lifetimes on r-process nucleosynthesis in the disc ejecta from neutron star mergers

NASA Astrophysics Data System (ADS)

Lippuner, Jonas; Fernández, Rodrigo; Roberts, Luke F.; Foucart, Francois; Kasen, Daniel; Metzger, Brian D.; Ott, Christian D.

2017-11-01

We investigate the nucleosynthesis of heavy elements in the winds ejected by accretion discs formed in neutron star mergers. We compute the element formation in disc outflows from hypermassive neutron star (HMNS) remnants of variable lifetime, including the effect of angular momentum transport in the disc evolution. We employ long-term axisymmetric hydrodynamic disc simulations to model the ejecta, and compute r-process nucleosynthesis with tracer particles using a nuclear reaction network containing ∼8000 species. We find that the previously known strong correlation between HMNS lifetime, ejected mass and average electron fraction in the outflow is directly related to the amount of neutrino irradiation on the disc, which dominates mass ejection at early times in the form of a neutrino-driven wind. Production of lanthanides and actinides saturates at short HMNS lifetimes (≲10 ms), with additional ejecta contributing to a blue optical kilonova component for longer-lived HMNSs. We find good agreement between the abundances from the disc outflow alone and the solar r-process distribution only for short HMNS lifetimes (≲10 ms). For longer lifetimes, the rare-earth and third r-process peaks are significantly underproduced compared to the solar pattern, requiring additional contributions from the dynamical ejecta. The nucleosynthesis signature from a spinning black hole (BH) can only overlap with that from an HMNS of moderate lifetime (≲60 ms). Finally, we show that angular momentum transport not only contributes with a late-time outflow component, but that it also enhances the neutrino-driven component by moving material to shallower regions of the gravitational potential, in addition to providing additional heating.

Effects of Age and Working Memory Load on Syntactic Processing: An Event-Related Potential Study.

PubMed

Alatorre-Cruz, Graciela C; Silva-Pereyra, Juan; Fernández, Thalía; Rodríguez-Camacho, Mario A; Castro-Chavira, Susana A; Sanchez-Lopez, Javier

2018-01-01

Cognitive changes in aging include working memory (WM) decline, which may hamper language comprehension. An increase in WM demands in older adults would probably provoke a poorer sentence processing performance in this age group. A way to increase the WM load is to separate two lexical units in an agreement relation (i.e., adjective and noun), in a given sentence. To test this hypothesis, event-related potentials (ERPs) were collected from Spanish speakers (30 older adults, mean age = 66.06 years old; and 30 young adults, mean age = 25.7 years old) who read sentences to detect grammatical errors. The sentences varied with regard to (1) the gender agreement of the noun and adjective, where the gender of the adjective either agreed or disagreed with the noun, and (2) the WM load (i.e., the number of words between the noun and adjective in the sentence). No significant behavioral differences between groups were observed in the accuracy of the response, but older adults showed longer reaction times regardless of WM load condition. Compared with young participants, older adults showed a different pattern of ERP components characterized by smaller amplitudes of LAN, P600a, and P600b effects when the WM load was increased. A smaller LAN effect probably reflects greater difficulties in processing the morpho-syntactic features of the sentence, while smaller P600a and P600b effects could be related to difficulties in recovering and mapping all sentence constituents. We concluded that the ERP pattern in older adults showed subtle problems in syntactic processing when the WM load was increased, which was not sufficient to affect response accuracy but was only observed to result in a longer reaction time.

Language-motor interference reflected in MEG beta oscillations.

PubMed

Klepp, Anne; Niccolai, Valentina; Buccino, Giovanni; Schnitzler, Alfons; Biermann-Ruben, Katja

2015-04-01

The involvement of the brain's motor system in action-related language processing can lead to overt interference with simultaneous action execution. The aim of the current study was to find evidence for this behavioural interference effect and to investigate its neurophysiological correlates using oscillatory MEG analysis. Subjects performed a semantic decision task on single action verbs, describing actions executed with the hands or the feet, and abstract verbs. Right hand button press responses were given for concrete verbs only. Therefore, longer response latencies for hand compared to foot verbs should reflect interference. We found interference effects to depend on verb imageability: overall response latencies for hand verbs did not differ significantly from foot verbs. However, imageability interacted with effector: while response latencies to hand and foot verbs with low imageability were equally fast, those for highly imageable hand verbs were longer than for highly imageable foot verbs. The difference is reflected in motor-related MEG beta band power suppression, which was weaker for highly imageable hand verbs compared with highly imageable foot verbs. This provides a putative neuronal mechanism for language-motor interference where the involvement of cortical hand motor areas in hand verb processing interacts with the typical beta suppression seen before movements. We found that the facilitatory effect of higher imageability on action verb processing time is perturbed when verb and motor response relate to the same body part. Importantly, this effect is accompanied by neurophysiological effects in beta band oscillations. The attenuated power suppression around the time of movement, reflecting decreased cortical excitability, seems to result from motor simulation during action-related language processing. This is in line with embodied cognition theories. Copyright © 2015. Published by Elsevier Inc.

Investigation of pouring temperature and holding time for semisolid metal feedstock production

NASA Astrophysics Data System (ADS)

Razak, N. A.; Ahmad, A. H.; Rashidi, M. M.

2017-10-01

Semisolid metal (SSM) processing, as a kind of new technology that exploits forming of alloys between solidus and liquidus temperatures, has attracted great attention from investigators for its thixotropic behaviour as well as having advantages in reducing porosity, macrosegregation, and forming forces during shaping process. Various techniques are employed to produce feedstock with fine globular microstructures, and direct thermal method is one of them. In this paper, the effect from different pouring temperatures and holding times using a direct thermal method on microstructure and hardness of aluminium alloy 6061 is presented. Molten aluminium alloy 6061 was poured into a cylindrical copper mould and cooled down to the semisolid temperature before being quenched in water at room temperature. The effect of different pouring temperatures of 660 °C, 680 °C, 700 °C, and holding time of 20 s, and 60 s on the microstructure of aluminium alloy 6061 were investigated. From the micrographs, it was found that the most globular structures were achieved at processing parameters of 660 °C pouring temperature and 60 s holding time. The highest density and hardness of the samples were found at the same processing parameters. It can be concluded that the most spheroidal microstructure, the highest density, and the hardness were recorded at lower pouring temperature and longer holding time.

Does mood influence text processing and comprehension? Evidence from an eye-movement study.

PubMed

Scrimin, Sara; Mason, Lucia

2015-09-01

Previous research has indicated that mood influences cognitive processes. However, there is scarce data regarding the link between everyday emotional states and readers' text processing and comprehension. We aim to extend current research on the effects of mood induction on science text processing and comprehension, using eye-tracking methodology. We investigated whether a positive-, negative-, and neutral-induced mood influences online processing, as revealed by indices of visual behaviour during reading, and offline text comprehension, as revealed by post-test questions. We were also interested in the link between text processing and comprehension. Seventy-eight undergraduate students randomly assigned to three mood-induction conditions. Students were mood-induced by watching a video clip. They were then asked to read a scientific text while eye movements were registered. Pre- and post-reading knowledge was assessed through open-ended questions. Experimentally induced moods lead readers to process an expository text differently. Overall, students in a positive mood spent significantly longer on the text processing than students in the negative and neutral moods. Eye-movement patterns indicated more effective processing related to longer proportion of look-back fixation times in positive-induced compared with negative-induced readers. Students in a positive mood also comprehended the text better, learning more factual knowledge, compared with students in the negative group. Only for the positive-induced readers did the more purposeful second-pass reading positively predict text comprehension. New insights are given on the effects of normal mood variations and students' text processing and comprehension by the use of eye-tracking methodology. Important implications for the role of emotional states in educational settings are highlighted. © 2015 The British Psychological Society.

National performance on door-in to door-out time among patients transferred for primary percutaneous coronary intervention.

PubMed

Herrin, Jeph; Miller, Lauren E; Turkmani, Dima F; Nsa, Wato; Drye, Elizabeth E; Bernheim, Susannah M; Ling, Shari M; Rapp, Michael T; Han, Lein F; Bratzler, Dale W; Bradley, Elizabeth H; Nallamothu, Brahmajee K; Ting, Henry H; Krumholz, Harlan M

2011-11-28

Delays in treatment time are commonplace for patients with ST-segment elevation acute myocardial infarction who must be transferred to another hospital for percutaneous coronary intervention. Experts have recommended that door-in to door-out (DIDO) time (ie, time from arrival at the first hospital to transfer from that hospital to the percutaneous coronary intervention hospital) should not exceed 30 minutes. We sought to describe national performance in DIDO time using a new measure developed by the Centers for Medicare & Medicaid Services. We report national median DIDO time and examine associations with patient characteristics (age, sex, race, contraindication to fibrinolytic therapy, and arrival time) and hospital characteristics (number of beds, geographic region, location [rural or urban], and number of cases reported) using a mixed effects multivariable model. Among 13,776 included patients from 1034 hospitals, only 1343 (9.7%) had a DIDO time within 30 minutes, and DIDO exceeded 90 minutes for 4267 patients (31.0%). Mean estimated times (95% CI) to transfer based on multivariable analysis were 8.9 (5.6-12.2) minutes longer for women, 9.1 (2.7-16.0) minutes longer for African Americans, 6.9 (1.6-11.9) minutes longer for patients with contraindication to fibrinolytic therapy, shorter for all age categories (except >75 years) relative to the category of 18 to 35 years, 15.3 (7.3-23.5) minutes longer for rural hospitals, and 14.4 (6.6-21.3) minutes longer for hospitals with 9 or fewer transfers vs 15 or more in 2009 (all P < .001). Among patients presenting to emergency departments and requiring transfer to another facility for percutaneous coronary intervention, the DIDO time rarely met the recommended 30 minutes.

National Performance on Door-In to Door-Out Time Among Patients Transferred for Primary Percutaneous Coronary Intervention

PubMed Central

Herrin, Jeph; Miller, Lauren E.; Turkmani, Dima F.; Nsa, Wato; Drye, Elizabeth E.; Bernheim, Susannah M.; Ling, Shari M.; Rapp, Michael T.; Han, Lein F.; Bratzler, Dale W.; Bradley, Elizabeth H.; Nallamothu, Brahmajee K.; Ting, Henry H.; Krumholz, Harlan M.

2015-01-01

Background Delays in treatment time are commonplace for patients with ST-segment elevation acute myocardial infarction who must be transferred to another hospital for per-cutaneous coronary intervention. Experts have recommended that door-in to door-out (DIDO) time(ie, time from arrival at the first hospital to transfer from that hospital to the percutaneous coronary intervention hospital) should not exceed 30 minutes. We sought to describe national performance in DIDO time using a new measure developed by the Centers for Medicare & Medicaid Services. Methods We report national median DIDO time and examine associations with patient characteristics (age, sex, race, contraindication to fibrinolytic therapy, and arrival time) and hospital characteristics (number of beds, geographic region, location [rural or urban], and number of cases reported) using a mixed effects multivariable model. Results Among 13 776 included patients from 1034 hospitals, only 1343 (9.7%) had a DIDO time within 30 minutes, and DIDO exceeded 90 minutes for 4267 patients (31.0%). Mean estimated times (95% CI) to transfer based on multivariable analysis were 8.9 (5.6-12.2) minutes longer for women, 9.1 (2.7-16.0) minutes longer for African Americans, 6.9 (1.6-11.9) minutes longer for patients with contraindication to fibrinolytic therapy, shorter for all age categories (except >75 years) relative to the category of 18 to 35 years, 15.3 (7.3-23.5) minutes longer for rural hospitals, and 14.4 (6.6-21.3) minutes longer for hospitals with 9 or fewer transfers vs 15 or more in 2009 (all P<.001). Conclusion Among patients presenting to emergency departments and requiring transfer to another facility for percutaneous coronary intervention, the DIDO time rarely met the recommended 30 minutes. PMID:22123793

Improvement of CFD Methods for Modeling Full Scale Circulating Fluidized Bed Combustion Systems

NASA Astrophysics Data System (ADS)

Shah, Srujal; Klajny, Marcin; Myöhänen, Kari; Hyppänen, Timo

With the currently available methods of computational fluid dynamics (CFD), the task of simulating full scale circulating fluidized bed combustors is very challenging. In order to simulate the complex fluidization process, the size of calculation cells should be small and the calculation should be transient with small time step size. For full scale systems, these requirements lead to very large meshes and very long calculation times, so that the simulation in practice is difficult. This study investigates the requirements of cell size and the time step size for accurate simulations, and the filtering effects caused by coarser mesh and longer time step. A modeling study of a full scale CFB furnace is presented and the model results are compared with experimental data.

Use of Six Sigma Methodology to Reduce Appointment Lead-Time in Obstetrics Outpatient Department.

PubMed

Ortiz Barrios, Miguel A; Felizzola Jiménez, Heriberto

2016-10-01

This paper focuses on the issue of longer appointment lead-time in the obstetrics outpatient department of a maternal-child hospital in Colombia. Because of extended appointment lead-time, women with high-risk pregnancy could develop severe complications in their health status and put their babies at risk. This problem was detected through a project selection process explained in this article and to solve it, Six Sigma methodology has been used. First, the process was defined through a SIPOC diagram to identify its input and output variables. Second, six sigma performance indicators were calculated to establish the process baseline. Then, a fishbone diagram was used to determine the possible causes of the problem. These causes were validated with the aid of correlation analysis and other statistical tools. Later, improvement strategies were designed to reduce appointment lead-time in this department. Project results evidenced that average appointment lead-time reduced from 6,89 days to 4,08 days and the deviation standard dropped from 1,57 days to 1,24 days. In this way, the hospital will serve pregnant women faster, which represents a risk reduction of perinatal and maternal mortality.

Understanding Preprocedure Patient Flow in IR.

PubMed

Zafar, Abdul Mueed; Suri, Rajeev; Nguyen, Tran Khanh; Petrash, Carson Cope; Fazal, Zanira

2016-08-01

To quantify preprocedural patient flow in interventional radiology (IR) and to identify potential contributors to preprocedural delays. An administrative dataset was used to compute time intervals required for various preprocedural patient-flow processes. These time intervals were compared across on-time/delayed cases and inpatient/outpatient cases by Mann-Whitney U test. Spearman ρ was used to assess any correlation of the rank of a procedure on a given day and the procedure duration to the preprocedure time. A linear-regression model of preprocedure time was used to further explore potential contributing factors. Any identified reason(s) for delay were collated. P < .05 was considered statistically significant. Of the total 1,091 cases, 65.8% (n = 718) were delayed. Significantly more outpatient cases started late compared with inpatient cases (81.4% vs 45.0%; P < .001, χ(2) test). The multivariate linear regression model showed outpatient status, length of delay in arrival, and longer procedure times to be significantly associated with longer preprocedure times. Late arrival of patients (65.9%), unavailability of physicians (18.4%), and unavailability of procedure room (13.0%) were the three most frequently identified reasons for delay. The delay was multifactorial in 29.6% of cases (n = 213). Objective measurement of preprocedural IR patient flow demonstrated considerable waste and highlighted high-yield areas of possible improvement. A data-driven approach may aid efficient delivery of IR care. Copyright © 2016 SIR. Published by Elsevier Inc. All rights reserved.

Evaluating the bakeout effectiveness of RTV-S691 silicone adhesive by measuring outgassing rate

NASA Astrophysics Data System (ADS)

Miyazaki, Eiji; Miura, Yuka; Numata, Osamu; Yamanaka, Riyo; Baba, Susumu; Ishizawa, Junichiro; Kimoto, Yugo; Tamura, Takashi

2014-09-01

Outgassing rate measurements are basically performed for fresh materials, e.g. just cured adhesives, paints, etc. and reveal a lot about how the material can behave as a contamination source. It is also important to determine the bakeout process sufficiently. In the present study, a typical silicone adhesive for use in space, RTV S-691, Wacker Chemie, was selected for the measurement. Two cured specimens, 40 × 40 mm in size, were applied for several isothermal tests under identical conditions: a specimen at 125 degrees C for 144 hours with CQCM at -193 degrees C to measure TML. Consequently, it was determined that the TML and TML rate could be reduced by bakeout as expected. It also emerged that a longer bakeout, i.e. a longer cumulative bakeout time, for the material would reduce the TML and TML rate more effectively. The results suggest that bakeout mainly affects the behavior in the "low-rate" phase, whereby the TML rate curve can be divided into two phases. The elapsed time for a specimen can also be considered the cumulative test time. Based on the cumulative elapsed time, the TML rate curve is replotted and a correlation emerges between the cumulative bakeout time and TML rate. The first measurement data of TML and the TML rate could be affected by the stored time from cure, which might result from the change in unreacted substances declining as the stored time elapsed.

An Automated Energy Detection Algorithm Based on Morphological Filter Processing with a Semi-Disk Structure

DTIC Science & Technology

2018-01-01

statistical moments of order 2, 3, and 4. The probability density function (PDF) of the vibrational time series of a good bearing has a Gaussian...ARL-TR-8271 ● JAN 2018 US Army Research Laboratory An Automated Energy Detection Algorithm Based on Morphological Filter...when it is no longer needed. Do not return it to the originator. ARL-TR-8271 ● JAN 2018 US Army Research Laboratory An Automated

Optimal electromagnetic energy transmission and real-time dissipation in extended media.

PubMed

Glasgow, S; Ware, M

2014-02-24

Pulse reshaping effects that give rise to fast and slow light phenomena are inextricably linked to the dynamics of energy exchange between the pulse and the propagation medium. Energy that is dissipated from the pulse can no longer participate in this exchange process, but previous methods of calculating real-time dissipation are not valid for extended propagation media. We present a method for calculating real-time dissipation that is valid for electromagnetic pulse propagation in extended media. This method allows one to divide the energy stored in an extended medium into the portion that can be later transmitted out of the medium, and that portion which must be lost to either dissipation or reflection.

Protecting a quantum memory for a photonic polarization qubit in a cold atomic ensemble by dynamical decoupling.

PubMed

Wu, Yuelong; Chen, Lirong; Xu, Zhongxiao; Wang, Hai

2014-09-22

We report an experimental demonstration of storage of photonic polarization qubit (PPQ) protected by dynamical decoupling (DD). PPQ's states are stored as a superposition of two spin waves by electromagnetically-induced-transparency (EIT). Carr-Purcell-Meiboom-Gill (CPMG) DD sequences are applied to the spin-wave superposition to suppress its decoherence. Thus, the quantum process fidelity remains better than 0.8 for up to 800 μs storage time, which is 3.4-times longer than the corresponding storage time of ~180 μs without the CPMG sequences. This work is a key step towards the storage of single-photon polarization qubit protected by the CPMG sequences.

Eye Movement Evidence for Hierarchy Effects on Memory Representation of Discourses.

PubMed

Wu, Yingying; Yang, Xiaohong; Yang, Yufang

2016-01-01

In this study, we applied the text-change paradigm to investigate whether and how discourse hierarchy affected the memory representation of a discourse. Three kinds of three-sentence discourses were constructed. In the hierarchy-high condition and the hierarchy-low condition, the three sentences of the discourses were hierarchically organized and the last sentence of each discourse was located at the high level and the low level of the discourse hierarchy, respectively. In the linear condition, the three sentences of the discourses were linearly organized. Critical words were always located at the last sentence of the discourses. These discourses were successively presented twice and the critical words were changed to semantically related words in the second presentation. The results showed that during the early processing stage, the critical words were read for longer times when they were changed in the hierarchy-high and the linear conditions, but not in the hierarchy-low condition. During the late processing stage, the changed-critical words were again found to induce longer reading times only when they were in the hierarchy-high condition. These results suggest that words in a discourse have better memory representation when they are located at the higher rather than at the lower level of the discourse hierarchy. Global discourse hierarchy is established as an important factor in constructing the mental representation of a discourse.

Eye Movement Evidence for Hierarchy Effects on Memory Representation of Discourses

PubMed Central

Wu, Yingying; Yang, Xiaohong; Yang, Yufang

2016-01-01

In this study, we applied the text-change paradigm to investigate whether and how discourse hierarchy affected the memory representation of a discourse. Three kinds of three-sentence discourses were constructed. In the hierarchy-high condition and the hierarchy-low condition, the three sentences of the discourses were hierarchically organized and the last sentence of each discourse was located at the high level and the low level of the discourse hierarchy, respectively. In the linear condition, the three sentences of the discourses were linearly organized. Critical words were always located at the last sentence of the discourses. These discourses were successively presented twice and the critical words were changed to semantically related words in the second presentation. The results showed that during the early processing stage, the critical words were read for longer times when they were changed in the hierarchy-high and the linear conditions, but not in the hierarchy-low condition. During the late processing stage, the changed-critical words were again found to induce longer reading times only when they were in the hierarchy-high condition. These results suggest that words in a discourse have better memory representation when they are located at the higher rather than at the lower level of the discourse hierarchy. Global discourse hierarchy is established as an important factor in constructing the mental representation of a discourse. PMID:26789002

Relapse prevention and smoking cessation.

PubMed

Davis, J R; Glaros, A G

1986-01-01

A multicomponent smoking relapse prevention treatment based on Marlatt and Gordon's (1980) model of the relapse process was developed and evaluated. Behavior-analytic methods were used to develop assessment instruments, training situations, and coping responses. The prevention components were presented in the context of a basic broad-spectrum stop-smoking program, and were compared with the basic program plus discussion control, and the basic program alone. Smoking-related dependent variables generally did not differ between groups at any time from pre-treatment to 12 month follow-up. Only the subjects in the relapse prevention condition improved problem-solving and social skills needed to cope with high-risk situations. These subjects also tended to take longer to relapse and smoke fewer cigarettes at the time of relapse. Subjects above the median level of competence on measures of social skill at post-treatment remained abstinent significantly longer. Maintenance of non-smoking was found to be related to the degree of competence with which individuals deal with high-risk situations. Results are discussed in relation to models of compliance with therapeutic regimens.

Autogenic geomorphic processes determine the resolution and fidelity of terrestrial paleoclimate records.

PubMed

Foreman, Brady Z; Straub, Kyle M

2017-09-01

Terrestrial paleoclimate records rely on proxies hosted in alluvial strata whose beds are deposited by unsteady and nonlinear geomorphic processes. It is broadly assumed that this renders the resultant time series of terrestrial paleoclimatic variability noisy and incomplete. We evaluate this assumption using a model of oscillating climate and the precise topographic evolution of an experimental alluvial system. We find that geomorphic stochasticity can create aliasing in the time series and spurious climate signals, but these issues are eliminated when the period of climate oscillation is longer than a key time scale of internal dynamics in the geomorphic system. This emergent autogenic geomorphic behavior imparts regularity to deposition and represents a natural discretization interval of the continuous climate signal. We propose that this time scale in nature could be in excess of 10 4 years but would still allow assessments of the rates of climate change at resolutions finer than the existing age model techniques in isolation.

Tracking performance under time sharing conditions with a digit processing task: A feedback control theory analysis. [attention sharing effect on operator performance

NASA Technical Reports Server (NTRS)

Gopher, D.; Wickens, C. D.

1975-01-01

A one dimensional compensatory tracking task and a digit processing reaction time task were combined in a three phase experiment designed to investigate tracking performance in time sharing. Adaptive techniques, elaborate feedback devices, and on line standardization procedures were used to adjust task difficulty to the ability of each individual subject and manipulate time sharing demands. Feedback control analysis techniques were employed in the description of tracking performance. The experimental results show that when the dynamics of a system are constrained, in such a manner that man machine system stability is no longer a major concern of the operator, he tends to adopt a first order control describing function, even with tracking systems of higher order. Attention diversion to a concurrent task leads to an increase in remnant level, or nonlinear power. This decrease in linearity is reflected both in the output magnitude spectra of the subjects, and in the linear fit of the amplitude ratio functions.

Media processors using a new microsystem architecture designed for the Internet era

NASA Astrophysics Data System (ADS)

Wyland, David C.

1999-12-01

The demands of digital image processing, communications and multimedia applications are growing more rapidly than traditional design methods can fulfill them. Previously, only custom hardware designs could provide the performance required to meet the demands of these applications. However, hardware design has reached a crisis point. Hardware design can no longer deliver a product with the required performance and cost in a reasonable time for a reasonable risk. Software based designs running on conventional processors can deliver working designs in a reasonable time and with low risk but cannot meet the performance requirements. What is needed is a media processing approach that combines very high performance, a simple programming model, complete programmability, short time to market and scalability. The Universal Micro System (UMS) is a solution to these problems. The UMS is a completely programmable (including I/O) system on a chip that combines hardware performance with the fast time to market, low cost and low risk of software designs.

Autogenic geomorphic processes determine the resolution and fidelity of terrestrial paleoclimate records

PubMed Central

Foreman, Brady Z.; Straub, Kyle M.

2017-01-01

Terrestrial paleoclimate records rely on proxies hosted in alluvial strata whose beds are deposited by unsteady and nonlinear geomorphic processes. It is broadly assumed that this renders the resultant time series of terrestrial paleoclimatic variability noisy and incomplete. We evaluate this assumption using a model of oscillating climate and the precise topographic evolution of an experimental alluvial system. We find that geomorphic stochasticity can create aliasing in the time series and spurious climate signals, but these issues are eliminated when the period of climate oscillation is longer than a key time scale of internal dynamics in the geomorphic system. This emergent autogenic geomorphic behavior imparts regularity to deposition and represents a natural discretization interval of the continuous climate signal. We propose that this time scale in nature could be in excess of 104 years but would still allow assessments of the rates of climate change at resolutions finer than the existing age model techniques in isolation. PMID:28924607

Micro-resonator-based electric field sensors with long durations of sensitivity

NASA Astrophysics Data System (ADS)

Ali, Amir R.

2017-05-01

In this paper, we present a new fabrication method for the whispering gallery mode (WGM) micro-sphere based electric field sensor that which allows for longer time periods of sensitivity. Recently, a WGM-based photonic electric field sensor was proposed using a coupled dielectric microsphere-beam. The external electric field imposes an electrtrostriction force on the dielectric beam, deflecting it. The beam, in turn compresses the sphere causing a shift in its WGM. As part of the fabrication process, the PDMS micro-beams and the spheres are curied at high-temperature (100oC) and subsequently poled by exposing to strong external electric field ( 8 MV/m) for two hours. The poling process allows for the deposition of surface charges thereby increasing the electrostriction effect. This methodology is called curing-then-poling (CTP). Although the sensors do become sufficiently sensitive to electric field, they start de-poling after a short period (within 10 minutes) after poling, hence losing sensitivity. In an attempt to mitigate this problem and to lock the polarization for a longer period, we use an alternate methodology whereby the beam is poled and cured simultaneously (curing-while-poling or CWP). The new fabrication method allows for the retention of polarization (and hence, sensitivity to electric field) longer ( 1500 minutes). An analysis is carried out along with preliminary experiments. Results show that electric fields as small as 100 V/m can be detected with a 300 μm diameter sphere sensor a day after poling.

Template directed assembly of nanoelements in viscous polymer environments

NASA Astrophysics Data System (ADS)

Modi, Satyamkumar

Polymer melt-based manufacturing methods, such as injection molding, offer the potential of directly fabricating three-dimensional parts with nanostructured surfaces in a one-step, high-rate, and solventless process. Electrophoretic deposition has the potential to produce in-mold assembly of nanoparticles during injection molding. The process is fast, is cost effective and can be automated. This electrophoretic deposition, however, has been performed from low-viscosity media and polymer melts are far more viscous. This research provided a fundamental understanding of the electrophoretic deposition process in viscous media. Electrophoresis was performed using a model system of carbon black and polystyrene in tetrahydrofuran (THF). Examined were the effects of processing parameters, polystyrene molecular weight, and carbon black charge. The presence of polystyrene did not prevent deposition of carbon black, but deposition rates decreased at shorter deposition times; deposition was not linear with increasing applied voltage; and greater solution concentrations reduced the critical voltages. A comparison of experimental data with Hamaker's model showed that about 1.6% of the available polystyrene was initially deposited with the carbon black. At voltages above the critical voltage, the deposited mass indicated formation of electrically insulating layers on the electrodes. Increases in polystyrene molecular weight reduced the electrophoretic deposition of the carbon black particles due to increases in suspension viscosity and preferential adsorption of the longer polystyrene chains on the carbon black particles. At low deposition times (≤ 5 seconds), only carbon black deposited onto the electrodes. For longer deposition times, polystyrene co-deposited with the carbon black, with the amount of polystyrene increasing with molecular weight and decreasing with greater charge on the polystyrene molecules. The additional of function groups to the carbon black surface decoupled the carbon black and polystyrene, however, the deposition of the carbon black particles, followed by deposition of a thick layer of polystyrene was observed. This polystyrene deposition was present regardless of the applied voltage, the deposition time, the polystyrene molecular weight, polystyrene material (i.e., charge), and solvent polarity. This deposition behavior suggests that use of lower molecular polymers and unmodified carbon blacks, and control of electrical properties will permit electrophoretic deposition of nanoparticles from polymer melts.

TEMPORAL EVOLUTION AND SPATIAL DISTRIBUTION OF WHITE-LIGHT FLARE KERNELS IN A SOLAR FLARE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kawate, T.; Ishii, T. T.; Nakatani, Y.

2016-12-10

On 2011 September 6, we observed an X2.1-class flare in continuum and H α with a frame rate of about 30 Hz. After processing images of the event by using a speckle-masking image reconstruction, we identified white-light (WL) flare ribbons on opposite sides of the magnetic neutral line. We derive the light curve decay times of the WL flare kernels at each resolution element by assuming that the kernels consist of one or two components that decay exponentially, starting from the peak time. As a result, 42% of the pixels have two decay-time components with average decay times of 15.6 andmore » 587 s, whereas the average decay time is 254 s for WL kernels with only one decay-time component. The peak intensities of the shorter decay-time component exhibit good spatial correlation with the WL intensity, whereas the peak intensities of the long decay-time components tend to be larger in the early phase of the flare at the inner part of the flare ribbons, close to the magnetic neutral line. The average intensity of the longer decay-time components is 1.78 times higher than that of the shorter decay-time components. If the shorter decay time is determined by either the chromospheric cooling time or the nonthermal ionization timescale and the longer decay time is attributed to the coronal cooling time, this result suggests that WL sources from both regions appear in 42% of the WL kernels and that WL emission of the coronal origin is sometimes stronger than that of chromospheric origin.« less

Impact of storage prior to cryopreservation on plasma membrane function and fertility of boar sperm.

PubMed

Guthrie, H D; Welch, G R

2005-01-15

Occasionally, boar semen must be shipped to another location for cryopreservation. We increased the initial holding time for the cooling of extended semen at 15 degrees C from 3 to 24 h to determine the effects on sperm characteristics and fertility. Thirty-one gilts and sows were inseminated once with subsequently cryopreserved and thawed semen. Increasing the holding time from 3 to 24 h had no significant effect on pregnancy rate 23 days after AI with frozen-thawed semen (64.5%) but decreased (P<0.05) embryo number from 15 to 9 and recovered embryos as fraction of CL from 73 to 47%. While the longer holding time at 15 degrees C did decrease potential litter size, the loss incurred was not too great to preclude the incorporation of a longer holding time into the cryopreservation protocol. An experiment was conducted to test the hypothesis that processing and freeze-thawing of boar semen would induce phospholipid scrambling in the plasma membrane similar to that evoked by incubation in bicarbonate-containing media. Merocyanine staining after incubation in the presence and absence of bicarbonate indicated that changes in plasma membrane phospholipid scrambling of processed and cryopreserved sperm differed from those in fresh semen undergoing bicarbonate-induced capacitation. The level of Annexin-V binding in boar spermatozoa increased from 1.6% in live spermatozoa in fresh semen to 18.7% in cryopreserved sperm. Apoptosis is unlikely to operate in mature spermatozoa. Apoptotic morphology in ejaculated spermatozoa is probably a result of incomplete deletion of apoptotic spermatocytes during spermatogenesis. Increased Annexin-V binding in thawed spermatozoa probably results from plasma membrane damage incurred during freezing and thawing.

Epizoochorous dispersal by ungulates depends on fur, grooming and social interactions.

PubMed

Liehrmann, Océane; Jégoux, Flore; Guilbert, Marie-Alice; Isselin-Nondedeu, Francis; Saïd, Sonia; Locatelli, Yann; Baltzinger, Christophe

2018-02-01

The transport phase of the animal-mediated plant dispersal process is critical to dispersal effectiveness as it determines the spatial distribution of the diaspores released and their chance for further recruitment. Assessing this specific phase of the dispersal process generally requires combining diaspore retention times with the associated distances covered. Here, we specifically tested the effect of grooming behavior, interindividual contacts and ungulate fur on diaspore retention times and associated dispersal distances for the hooked diaspores of Xanthium strumarium L. experimentally attached to tamed individuals of three ungulate species. We used a comparative approach based on differing fur quality on different body zones of these three ungulates. During 6-hr sessions, we monitored for grooming and social interactions that may induce intended or inadvertent diaspore detachment. Additionally, we proposed innovative approaches to directly assessing diaspore dispersal distances by red deer in situ. Fat-tailed functions fitted diaspore retention time, highlighting the potential for long-distance dispersal events. The longer the hair, the higher the retention capacity of diaspores in the animal's fur. As predicted, donkey retained diaspores longer than red deer and dwarf goat; and we also confirmed that diaspores attached to the short hair of the head fell off more quickly than did those on the other body zones. Dwarf goat groomed more often than both red deer and donkey, but also when it carried diaspores. Up to 14% of the diaspores detached from animal fur after specific grooming behavior. We observed, in controlled conditions, for the first time and for each ungulate species, interindividual transfers of diaspores, representing 5% of the diaspores attached to animals' fur. Our results militate for incorporating animal behavior into plant dispersal modeling approaches.

Evidence for auditory-visual processing specific to biological motion.

PubMed

Wuerger, Sophie M; Crocker-Buque, Alexander; Meyer, Georg F

2012-01-01

Biological motion is usually associated with highly correlated sensory signals from more than one modality: an approaching human walker will not only have a visual representation, namely an increase in the retinal size of the walker's image, but also a synchronous auditory signal since the walker's footsteps will grow louder. We investigated whether the multisensorial processing of biological motion is subject to different constraints than ecologically invalid motion. Observers were presented with a visual point-light walker and/or synchronised auditory footsteps; the walker was either approaching the observer (looming motion) or walking away (receding motion). A scrambled point-light walker served as a control. Observers were asked to detect the walker's motion as quickly and as accurately as possible. In Experiment 1 we tested whether the reaction time advantage due to redundant information in the auditory and visual modality is specific for biological motion. We found no evidence for such an effect: the reaction time reduction was accounted for by statistical facilitation for both biological and scrambled motion. In Experiment 2, we dissociated the auditory and visual information and tested whether inconsistent motion directions across the auditory and visual modality yield longer reaction times in comparison to consistent motion directions. Here we find an effect specific to biological motion: motion incongruency leads to longer reaction times only when the visual walker is intact and recognisable as a human figure. If the figure of the walker is abolished by scrambling, motion incongruency has no effect on the speed of the observers' judgments. In conjunction with Experiment 1 this suggests that conflicting auditory-visual motion information of an intact human walker leads to interference and thereby delaying the response.

How many hours do people sleep in Bangladesh? A country-representative survey.

PubMed

Yunus, Fakir M; Khan, Safayet; Akter, Tahera; Jhohura, Fatema T; Reja, Saifur; Islam, Akramul; Rahman, Mahfuzar

2016-06-01

This study investigated total sleep time in the Bangladeshi population and identified the proportion of the population at greater risk of developing chronic diseases due to inadequate sleep. Using a cross-sectional survey, total sleep time was captured and analysed in 3968 respondents aged between 6 and 106 years in 24 (of 64) districts in Bangladesh. Total sleep time was defined as the hours of total sleep in the previous 24 h. We used National Sleep Foundation (2015) guidelines to determine the recommended sleep hours in different age categories. Less or more than the recommended total sleep time (in hours) was considered 'shorter' and 'longer' sleep time, respectively. Linear and multinomial logistic regression models were used to determine the relationship between demographic variables and estimated risk of shorter and longer total sleep time. The mean (±standard deviation) total sleep time of children (6-13 years), teenagers (14-17 years), young adults and adults (18-64 years) and older adults (≥65 years) were 8.6 (±1.1), 8.1 (±1.0), 7.7 (±0.9) and 7.8 (±1.4) h, respectively, which were significantly different (P < 0.01). More than half of school-age children (55%) slept less than, and 28.2% of older adults slept longer than, recommended. Residents in all divisions (except Chittagong) in Bangladesh were less likely to sleep longer than in the Dhaka division. Rural populations had a 3.96× greater chance of sleeping for a shorter time than urban residents. The Bangladeshi population tends to sleep for longer and/or shorter times than their respective recommended sleep hours, which is detrimental to health. © 2016 European Sleep Research Society.

Processing deficits and the mediation of positive affect in persuasion.

PubMed

Mackie, D M; Worth, L T

1989-07-01

Motivational and cognitive mediators of the reduced processing of persuasive messages shown by recipients in a positive mood were tested. Ss in positive or neutral moods read strong or weak counterattitudinal advocadies for either a limited time or for as long as they wanted. Under limited exposure conditions, neutral mood Ss showed attitude change indicative of systemic processing, whereas positive mood Ss showed no differentiation of strong and weak versions of the message. When message exposure was unlimited, positive mood Ss viewed the message longer than did neutral mood Ss and systematically processed it rather than relying on persuasion heuristics. These findings replicated with 2 manipulations of mood and 2 different attitude issues. We interpret the results as providing evidence that reduced cognitive capacity to process the message contributes to the decrements shown by positive mood Ss.

The analysis of verbal interaction sequences in dyadic clinical communication: a review of methods.

PubMed

Connor, Martin; Fletcher, Ian; Salmon, Peter

2009-05-01

To identify methods available for sequential analysis of dyadic verbal clinical communication and to review their methodological and conceptual differences. Critical review, based on literature describing sequential analyses of clinical and other relevant social interaction. Dominant approaches are based on analysis of communication according to its precise position in the series of utterances that constitute event-coded dialogue. For practical reasons, methods focus on very short-term processes, typically the influence of one party's speech on what the other says next. Studies of longer-term influences are rare. Some analyses have statistical limitations, particularly in disregarding heterogeneity between consultations, patients or practitioners. Additional techniques, including ones that can use information about timing and duration of speech from interval-coding are becoming available. There is a danger that constraints of commonly used methods shape research questions and divert researchers from potentially important communication processes including ones that operate over a longer-term than one or two speech turns. Given that no one method can model the complexity of clinical communication, multiple methods, both quantitative and qualitative, are necessary. Broadening the range of methods will allow the current emphasis on exploratory studies to be balanced by tests of hypotheses about clinically important communication processes.

Brain hemodynamic activity during viewing and re-viewing of comedy movies explained by experienced humor

PubMed Central

Jääskeläinen, Iiro P.; Pajula, Juha; Tohka, Jussi; Lee, Hsin-Ju; Kuo, Wen-Jui; Lin, Fa-Hsuan

2016-01-01

Humor is crucial in human social interactions. To study the underlying neural processes, three comedy clips were shown twice to 20 volunteers during functional magnetic resonance imaging (fMRI). Inter-subject similarities in humor ratings, obtained immediately after fMRI, explained inter-subject correlation of hemodynamic activity in right frontal pole and in a number of other brain regions. General linear model analysis also indicated activity in right frontal pole, as well as in additional cortical areas and subcortically in striatum, explained by humorousness. The association of the right frontal pole with experienced humorousness is a novel finding, which might be related to humor unfolding over longer time scales in the movie clips. Specifically, frontal pole has been shown to exhibit longer temporal receptive windows than, e.g., sensory areas, which might have enabled processing of humor in the clips based on holding information and reinterpreting that in light of new information several (even tens of) seconds later. As another novel finding, medial and lateral prefrontal areas, frontal pole, posterior-inferior temporal areas, posterior parietal areas, posterior cingulate, striatal structures and amygdala showed reduced activity upon re-viewing of the clips, suggesting involvement in processing of humor related to novelty of the comedic events. PMID:27323928

Nanoscale soldering of axially positioned single-walled carbon nanotubes: a molecular dynamics simulation study.

PubMed

Cui, Jianlei; Yang, Lijun; Zhou, Liang; Wang, Yang

2014-02-12

The miniaturization of electronics devices into the nanometer scale is indispensable for next-generation semi-conductor technology. Carbon nanotubes (CNTs) are considered to be the promising candidates for future interconnection wires. To study the carbon nanotubes interconnection during nanosoldering, the melting process of nanosolder and nanosoldering process between single-walled carbon nanotubes are simulated with molecular dynamics method. As the simulation results, the melting point of 2 nm silver solder is about 605 K because of high surface energy, which is below the melting temperature of Ag bulk material. In the nanosoldering process simulations, Ag atoms may be dragged into the nanotubes to form different connection configuration, which has no apparent relationship with chirality of SWNTs. The length of core filling nanowires structure has the relationship with the diameter, and it does not become longer with the increasing diameter of SWNT. Subsequently, the dominant mechanism of was analyzed. In addition, as the heating temperature and time, respectively, increases, more Ag atoms can enter the SWNTs with longer length of Ag nanowires. And because of the strong metal bonds, less Ag atoms can remain with the tight atomic structures in the gap between SWNT and SWNT. The preferred interconnection configurations can be achieved between SWNT and SWNT in this paper.

Possession Zone as a Performance Indicator in Football. The Game of the Best Teams.

PubMed

Casal, Claudio A; Maneiro, Rubén; Ardá, Toni; Marí, Francisco J; Losada, José L

2017-01-01

Possession time in football has been widely discussed in research but few studies have analyzed the importance of the field area in which possession occurs. The objective of this study was to identify the existence of significant differences in the field zone of ball possession between successful and unsuccessful teams and to acknowledge if the match status modulates the possession model. To this end, 2,284 attacks were analyzed corresponding to the matches in the final phase of the UEFA Euro 2016 France, recording possession time and field zone in which possession occurred. Video recordings of matches were analyzed and coded post-event using notational analysis. We have found that successful offensive game patterns are different from unsuccessful ones. Specifically, field zone in which major possession occurs changes significantly between successful and unsuccessful teams ( x 2 = 15.72, p < 0.05) and through Welch's T significant differences were detected in possession time between successful and unsuccessful teams ( H = 24.289, p < 0.001). The former are characterized by longer possession times, preferably in the middle offensive zone, on the other hand, unsuccessful teams have shorter possession times and preferably on the middle defensive zone. Logistic regression also allowed us to identify that greater possession in the middle offensive zone is a good indicator of success in the offensive game, allowing us to predict a greater chance of victory in the match. Specifically, every time the teams achieve possession in the middle offensive zone, the chance of winning the match will increase 1.72 times and, the probability of winning the match making longer possessions in the middle offensive zone is 44.25%. Applying the Kruskal-Wallis test we have also been able to verify how match status modulates the teams possession time, specifically, when teams are winning they have longer possessions x 2 = 92.628, p = 0.011. Results obtained are expected to help gain more knowledge about successful offensive game models, as well as performance factors of the offensive phase, which will allow teams to optimize their training process and performance during the match.

Possession Zone as a Performance Indicator in Football. The Game of the Best Teams

PubMed Central

Casal, Claudio A.; Maneiro, Rubén; Ardá, Toni; Marí, Francisco J.; Losada, José L.

2017-01-01

Possession time in football has been widely discussed in research but few studies have analyzed the importance of the field area in which possession occurs. The objective of this study was to identify the existence of significant differences in the field zone of ball possession between successful and unsuccessful teams and to acknowledge if the match status modulates the possession model. To this end, 2,284 attacks were analyzed corresponding to the matches in the final phase of the UEFA Euro 2016 France, recording possession time and field zone in which possession occurred. Video recordings of matches were analyzed and coded post-event using notational analysis. We have found that successful offensive game patterns are different from unsuccessful ones. Specifically, field zone in which major possession occurs changes significantly between successful and unsuccessful teams (x2 = 15.72, p < 0.05) and through Welch’s T significant differences were detected in possession time between successful and unsuccessful teams (H = 24.289, p < 0.001). The former are characterized by longer possession times, preferably in the middle offensive zone, on the other hand, unsuccessful teams have shorter possession times and preferably on the middle defensive zone. Logistic regression also allowed us to identify that greater possession in the middle offensive zone is a good indicator of success in the offensive game, allowing us to predict a greater chance of victory in the match. Specifically, every time the teams achieve possession in the middle offensive zone, the chance of winning the match will increase 1.72 times and, the probability of winning the match making longer possessions in the middle offensive zone is 44.25%. Applying the Kruskal–Wallis test we have also been able to verify how match status modulates the teams possession time, specifically, when teams are winning they have longer possessions x2 = 92.628, p = 0.011. Results obtained are expected to help gain more knowledge about successful offensive game models, as well as performance factors of the offensive phase, which will allow teams to optimize their training process and performance during the match. PMID:28769833

Quarantine versus pathogen-reduced plasma-coagulation factor content and rotational thromboelastometry coagulation.

PubMed

Theusinger, Oliver M; Goslings, David; Studt, Jan-Dirk; Brand-Staufer, Brigitte; Seifert, Burkhardt; Spahn, Donat R; Frey, Beat M

2017-03-01

Different types of fresh-frozen plasma (FFP) exist, and the concentrations of plasma proteins vary between individuals and blood groups. Furthermore, processing may also influence the content. Quarantine-stored plasma (qFFP) and plasma that was pathogen-reduced using blood-safety (Intercept) technology (piFFP) were analyzed regarding procoagulant and anticoagulant hemostasis proteins, including endogenous thrombin (thrombin-generation) potential (ETP). Thirty-five samples of each type of FFP were analyzed using only male Blood Group O donors. FFP units were stored frozen for comparable periods of time before plasma protein content was assessed. Once the units were thawed, all tests were completed within 4 hours. The results are presented as means ± standard deviations or as median (minimum; maximum) and were compared using independent-sample t tests (significance, p < 0.01). Significantly higher concentrations of adintegrin-like and metalloprotease with thrombospondin type-13 motifs (ADAMTS13), fibrinogen, Factor (F)V, FVIII, FXIII, protein S, protein S activity, antithrombin, microvesicle (<900 nm), and α2 antiplasmin were observed in qFFP. The variability of factors was significantly lower in piFFP. Tissue factor (TF) at 1 picomolar (pM) exhibited significantly longer lag time, a lower peak, lower ETP, and a lower velocity index in qFFP compared with piFFP. In TF at 5 pM, significant differences in lag time (longer in qFFP), velocity index (lower in qFFP), and peak (lower in qFFP) were observed. Rotational thromboelastometry revealed a significantly longer (p = 0.002) clot-formation time with intrinsic thromboelastometry for piFFP and a significantly shorter clotting time (p = 0.004) with thromboelastometry fibrinogen testing for piFFP. Pathogen reduction reduces procoagulant and anticoagulant coagulation factors as well as variability. A thrombin-generation assay showed no reduced ETP and no supraphysiological thrombin generation. None of the FFP preparations is likely to be effective for treating fibrinogen deficiency. © 2016 AABB.

Return to normal activities and work after living donor laparoscopic nephrectomy.

PubMed

Larson, Dawn B; Jacobs, Cheryl; Berglund, Danielle; Wiseman, Jennifer; Garvey, Catherine; Gillingham, Kristen; Ibrahim, Hassan N; Matas, Arthur J

2017-01-01

Transplant programs inform potential donors that they should be able to return to normal activities within ~2 weeks and to work by 6 weeks after laparoscopic nephrectomy. We studied actual time. Between 10/2004 and 9/2014, 911 donors having laparoscopic nephrectomy were surveyed 6 months post-donation. Surveys asked questions specific to their recovery experience, including time to return to normal activities and work and a description of their recovery time relative to pre-donation expectations. Of the 911, 646 (71%) responded: mean age at donation was 43.5±10.6 years; 65% were female, 95% were white, 51% were biologically related to their recipient, and 83% reported education beyond high school. Of the 646 respondents, a total of 35% returned to normal activities by 2 weeks post-donation; 79% by 4 weeks post-donation; 94% by 5-6 weeks; however, 6% took >6 weeks. Of the 646, 551 (85%) were working for pay; of these, mean time to return to work was 5.3±2.8 weeks; median, 5 weeks. Of the 551, a total of 14% returned to work in 1-2 weeks, 46% by 3-4 weeks, and 76% by 5-6 weeks. Importantly, 24% required >6 weeks before returning to work with the highest rates for donors in manual labor or a skilled trade. Significantly longer return to work was reported by females (vs males; P=.01), those without (vs those with) post-high school education (P=.010, those with longer hospital stay (P=.01), and those with a postoperative complication (P=.02). Of respondents, 37% described their recovery time as longer than expected. During the donor informed consent process, additional emphasis on realistic expectations around recovery to baseline activities and return to work is warranted. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Surface regions of illusory images are detected with a slower processing speed than those of luminance-defined images.

PubMed

Mihaylova, Milena; Manahilov, Velitchko

2010-11-24

Research has shown that the processing time for discriminating illusory contours is longer than for real contours. We know, however, little whether the visual processes, associated with detecting regions of illusory surfaces, are also slower as those responsible for detecting luminance-defined images. Using a speed-accuracy trade-off (SAT) procedure, we measured accuracy as a function of processing time for detecting illusory Kanizsa-type and luminance-defined squares embedded in 2D static luminance noise. The data revealed that the illusory images were detected at slower processing speed than the real images, while the points in time, when accuracy departed from chance, were not significantly different for both stimuli. The classification images for detecting illusory and real squares showed that observers employed similar detection strategies using surface regions of the real and illusory squares. The lack of significant differences between the x-intercepts of the SAT functions for illusory and luminance-modulated stimuli suggests that the detection of surface regions of both images could be based on activation of a single mechanism (the dorsal magnocellular visual pathway). The slower speed for detecting illusory images as compared to luminance-defined images could be attributed to slower processes of filling-in of regions of illusory images within the dorsal pathway.

Accuracy of time-domain and frequency-domain methods used to characterize catchment transit time distributions

NASA Astrophysics Data System (ADS)

Godsey, S. E.; Kirchner, J. W.

2008-12-01

The mean residence time - the average time that it takes rainfall to reach the stream - is a basic parameter used to characterize catchment processes. Heterogeneities in these processes lead to a distribution of travel times around the mean residence time. By examining this travel time distribution, we can better predict catchment response to contamination events. A catchment system with shorter residence times or narrower distributions will respond quickly to contamination events, whereas systems with longer residence times or longer-tailed distributions will respond more slowly to those same contamination events. The travel time distribution of a catchment is typically inferred from time series of passive tracers (e.g., water isotopes or chloride) in precipitation and streamflow. Variations in the tracer concentration in streamflow are usually damped compared to those in precipitation, because precipitation inputs from different storms (with different tracer signatures) are mixed within the catchment. Mathematically, this mixing process is represented by the convolution of the travel time distribution and the precipitation tracer inputs to generate the stream tracer outputs. Because convolution in the time domain is equivalent to multiplication in the frequency domain, it is relatively straightforward to estimate the parameters of the travel time distribution in either domain. In the time domain, the parameters describing the travel time distribution are typically estimated by maximizing the goodness of fit between the modeled and measured tracer outputs. In the frequency domain, the travel time distribution parameters can be estimated by fitting a power-law curve to the ratio of precipitation spectral power to stream spectral power. Differences between the methods of parameter estimation in the time and frequency domain mean that these two methods may respond differently to variations in data quality, record length and sampling frequency. Here we evaluate how well these two methods of travel time parameter estimation respond to different sources of uncertainty and compare the methods to one another. We do this by generating synthetic tracer input time series of different lengths, and convolve these with specified travel-time distributions to generate synthetic output time series. We then sample both the input and output time series at various sampling intervals and corrupt the time series with realistic error structures. Using these 'corrupted' time series, we infer the apparent travel time distribution, and compare it to the known distribution that was used to generate the synthetic data in the first place. This analysis allows us to quantify how different record lengths, sampling intervals, and error structures in the tracer measurements affect the apparent mean residence time and the apparent shape of the travel time distribution.

Teaching the process of delegation.

PubMed

Adams, D

1995-12-01

Registered nurses can no longer expect to perform all patient care activities in this age of decentralization, shared governance, and redefining of work duties to include nurse extenders. Delegation is a much needed skill for hospital nurses, because it can free them to deal with professional activities of care, if it is learned and practiced over time. Practitioners of delegation must learn how to assess readiness for delegation in the extender and must recognize that delegation should be a planned process, not an act of desperation. Clear communication is critical at all stages of the process, and evaluation is necessary to be sure that the delegated tasks were completed accurately and promptly. The benefits of delegating far outweigh the loss of control and potential as a result of inconsistency.

Pupil measures of alertness and mental load

NASA Technical Reports Server (NTRS)

Backs, Richard W.; Walrath, Larry C.

1988-01-01

A study of eight adults given active and passive search tasks showed that evoked pupillary response was sensitive to information processing demands. In particular, large pupillary diameter was observed in the active search condition where subjects were actively processing information relevant to task performance, as opposed to the passive search (control) condition where subjects passively viewed the displays. However, subjects may have simply been more aroused in the active search task. Of greater importance was that larger pupillary diameter, corresponding to longer search time, was observed for noncoded than for color-coded displays in active search. In the control condition, pupil diameter was larger with the color displays. The data indicate potential usefulness of pupillary responses in evaluating the information processing requirements of visual displays.

Modeling aeolian transport in response to succession, disturbance and future climate: Dynamic long-term risk assessment for contaminant redistribution

USGS Publications Warehouse

Breshears, D.D.; Kirchner, T.B.; Whicker, J.J.; Field, J.P.; Allen, Craig D.

2012-01-01

Aeolian sediment transport is a fundamental process redistributing sediment, nutrients, and contaminants in dryland ecosystems. Over time frames of centuries or longer, horizontal sediment fluxes and associated rates of contaminant transport are likely to be influenced by succession, disturbances, and changes in climate, yet models of horizontal sediment transport that account for these fundamental factors are lacking, precluding in large part accurate assessment of human health risks associated with persistent soil-bound contaminants. We present a simple model based on empirical measurements of horizontal sediment transport (predominantly saltation) to predict potential contaminant transport rates for recently disturbed sites such as a landfill cover. Omnidirectional transport is estimated within vegetation that changes using a simple Markov model that simulates successional trajectory and considers three types of short-term disturbances (surface fire, crown fire, and drought-induced plant mortality) under current and projected climates. The model results highlight that movement of contaminated soil is sensitive to vegetation dynamics and increases substantially (e.g., > fivefold) when disturbance and/or future climate are considered. The time-dependent responses in horizontal sediment fluxes and associated contaminant fluxes were sensitive to variability in the timing of disturbance, with longer intervals between disturbance allowing woody plants to become dominant and crown fire and drought abruptly reducing woody plant cover. Our results, which have direct implications for contaminant transport and landfill management in the specific context of our assessment, also have general relevance because they highlight the need to more fully account for vegetation dynamics, disturbance, and changing climate in aeolian process studies.

Do greater mouse-eared bats experience a trade-off between energy conservation and learning?

PubMed

Ruczyński, Ireneusz; Clarin, Theresa M A; Siemers, Bjoern M

2014-11-15

Bats, some species of rodents and some birds are able to save energy during the summer period by decreasing their body temperature and falling into torpor. Some studies indicate that torpor prevents sleeping and causes effects similar to sleep deprivation. Impairment of processes stabilizing memory slows down learning accuracy and speed. We conducted two experiments to test whether greater mouse-eared bats, Myotis myotis, which commonly use torpor during the summer period, experience a trade-off between energy savings and learning abilities. We compared learning speed and accuracy in bats that were exposed to low (7°C) and higher ambient temperatures (22°C) between training and experimental sessions. Tests were conducted in experiments with food reward (food search) and without food reward (perch search). Time spent with the skin temperature above 30°C was significantly longer for bats exposed to 22°C than for those exposed to 7°C, and longer in experiments with food reward than without food reward. We observed only a very weak tendency for better accuracy and shorter search times in bats exposed to 22°C than in those exposed to 7°C. Our data indicate that memory consolidation of bats under natural conditions is not affected by daily torpor when bats are in good condition and may therefore defend against a rapid fall into torpor. We suggest that homeostatic processes connected with the circadian rhythm allow protection of the consolidation of memory for relatively simple tasks despite time spent in torpor. © 2014. Published by The Company of Biologists Ltd.

Collaborative Technology Assessments Of Transient Field Processing And Additive Manufacturing Technologies As Applied To Gas Turbine Components

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ludtka, Gerard Michael; Dehoff, Ryan R.; Szabo, Attila

2016-01-01

ORNL partnered with GE Power & Water to investigate the effect of thermomagnetic processing on the microstructure and mechanical properties of GE Power & Water newly developed wrought Ni-Fe-Cr alloys. Exploration of the effects of high magnetic field process during heat treatment of the alloys indicated conditions where applications of magnetic fields yields significant property improvements. The alloy aged using high magnetic field processing exhibited 3 HRC higher hardness compared to the conventionally-aged alloy. The alloy annealed at 1785 F using high magnetic field processing demonstrated an average creep life 2.5 times longer than that of the conventionally heat-treated alloy.more » Preliminary results show that high magnetic field processing can improve the mechanical properties of Ni-Fe-Cr alloys and potentially extend the life cycle of the gas turbine components such as nozzles leading to significant energy savings.« less

Time crawls when you're not having fun: feeling entitled makes dull tasks drag on.

PubMed

O'Brien, Edward H; Anastasio, Phyllis A; Bushman, Brad J

2011-10-01

All people have to complete dull tasks, but individuals who feel entitled may be more inclined to perceive them as a waste of their "precious" time, resulting in the perception that time drags. This hypothesis was confirmed in three studies. In Study 1, participants with higher trait entitlement (controlling for related variables) thought dull tasks took longer to complete; no link was found for fun tasks. In Study 2, participants exposed to entitled messages thought taking a dull survey was a greater waste of time and took longer to complete. In Study 3, participants subliminally exposed to entitled words thought dull tasks were less interesting, thought they took longer to complete, and walked away faster when leaving the laboratory. Like most resources, time is a resource valued more by entitled individuals. A time-entitlement link provides novel insight into mechanisms underlying self-focus and prosocial dynamics.

Making tomorrow's mistakes today: Evolutionary prototyping for risk reduction and shorter development time

NASA Astrophysics Data System (ADS)

Friedman, Gary; Schwuttke, Ursula M.; Burliegh, Scott; Chow, Sanguan; Parlier, Randy; Lee, Lorrine; Castro, Henry; Gersbach, Jim

1993-03-01

In the early days of JPL's solar system exploration, each spacecraft mission required its own dedicated data system with all software applications written in the mainframe's native assembly language. Although these early telemetry processing systems were a triumph of engineering in their day, since that time the computer industry has advanced to the point where it is now advantageous to replace these systems with more modern technology. The Space Flight Operations Center (SFOC) Prototype group was established in 1985 as a workstation and software laboratory. The charter of the lab was to determine if it was possible to construct a multimission telemetry processing system using commercial, off-the-shelf computers that communicated via networks. The staff of the lab mirrored that of a typical skunk works operation -- a small, multi-disciplinary team with a great deal of autonomy that could get complex tasks done quickly. In an effort to determine which approaches would be useful, the prototype group experimented with all types of operating systems, inter-process communication mechanisms, network protocols, packet size parameters. Out of that pioneering work came the confidence that a multi-mission telemetry processing system could be built using high-level languages running in a heterogeneous, networked workstation environment. Experience revealed that the operating systems on all nodes should be similar (i.e., all VMS or all PC-DOS or all UNIX), and that a unique Data Transport Subsystem tool needed to be built to address the incompatibilities of network standards, byte ordering, and socket buffering. The advantages of building a telemetry processing system based on emerging industry standards were numerous: by employing these standards, we would no longer be locked into a single vendor. When new technology came to market which offered ten times the performance at one eighth the cost, it would be possible to attach the new machine to the network, re-compile the application code, and run. In addition, we would no longer be plagued with lack of manufacturer support when we encountered obscure bugs. And maybe, hopefully, the eternal elusive goal of software portability across different vendors' platforms would finally be available. Some highlights of our prototyping efforts are described.

Making tomorrow's mistakes today: Evolutionary prototyping for risk reduction and shorter development time

NASA Technical Reports Server (NTRS)

Friedman, Gary; Schwuttke, Ursula M.; Burliegh, Scott; Chow, Sanguan; Parlier, Randy; Lee, Lorrine; Castro, Henry; Gersbach, Jim

1993-01-01

In the early days of JPL's solar system exploration, each spacecraft mission required its own dedicated data system with all software applications written in the mainframe's native assembly language. Although these early telemetry processing systems were a triumph of engineering in their day, since that time the computer industry has advanced to the point where it is now advantageous to replace these systems with more modern technology. The Space Flight Operations Center (SFOC) Prototype group was established in 1985 as a workstation and software laboratory. The charter of the lab was to determine if it was possible to construct a multimission telemetry processing system using commercial, off-the-shelf computers that communicated via networks. The staff of the lab mirrored that of a typical skunk works operation -- a small, multi-disciplinary team with a great deal of autonomy that could get complex tasks done quickly. In an effort to determine which approaches would be useful, the prototype group experimented with all types of operating systems, inter-process communication mechanisms, network protocols, packet size parameters. Out of that pioneering work came the confidence that a multi-mission telemetry processing system could be built using high-level languages running in a heterogeneous, networked workstation environment. Experience revealed that the operating systems on all nodes should be similar (i.e., all VMS or all PC-DOS or all UNIX), and that a unique Data Transport Subsystem tool needed to be built to address the incompatibilities of network standards, byte ordering, and socket buffering. The advantages of building a telemetry processing system based on emerging industry standards were numerous: by employing these standards, we would no longer be locked into a single vendor. When new technology came to market which offered ten times the performance at one eighth the cost, it would be possible to attach the new machine to the network, re-compile the application code, and run. In addition, we would no longer be plagued with lack of manufacturer support when we encountered obscure bugs. And maybe, hopefully, the eternal elusive goal of software portability across different vendors' platforms would finally be available. Some highlights of our prototyping efforts are described.

The impact of a streamlined funding application process on application time: two cross-sectional surveys of Australian researchers

PubMed Central

Barnett, Adrian G; Graves, Nicholas; Clarke, Philip; Herbert, Danielle

2015-01-01

Objective To examine if streamlining a medical research funding application process saved time for applicants. Design Cross-sectional surveys before and after the streamlining. Setting The National Health and Medical Research Council (NHMRC) of Australia. Participants Researchers who submitted one or more NHMRC Project Grant applications in 2012 or 2014. Main outcome measures Average researcher time spent preparing an application and the total time for all applications in working days. Results The average time per application increased from 34 working days before streamlining (95% CI 33 to 35) to 38 working days after streamlining (95% CI 37 to 39; mean difference 4 days, bootstrap p value <0.001). The estimated total time spent by all researchers on applications after streamlining was 614 working years, a 67-year increase from before streamlining. Conclusions Streamlined applications were shorter but took longer to prepare on average. Researchers may be allocating a fixed amount of time to preparing funding applications based on their expected return, or may be increasing their time in response to increased competition. Many potentially productive years of researcher time are still being lost to preparing failed applications. PMID:25596201

Presenting characteristics and processing times for culturally and linguistically diverse (CALD) patients with chest pain in an emergency department: Time, Ethnicity, and Delay (TED) Study II.

PubMed

Wechkunanukul, Kannikar; Grantham, Hugh; Teubner, David; Hyun, Karice K; Clark, Robyn A

2016-10-01

To date there has been limited published data presenting the characteristics and timeliness of the management in an Emergency Department (ED) for culturally and linguistically diverse (CALD) patients presenting with chest pain. This study aimed to describe the presenting characteristics and processing times for CALD patients with chest pain compared to the Australian-born population, and current guidelines. This study was a cross sectional analysis of a cohort of patients who presented with chest pain to the metropolitan hospital between 1 July 2012 and 30 June 2014. Of the total study population (n=6640), 1241 (18.7%) were CALD and 5399 (81.3%) were Australian-born. CALD patients were significantly older than Australian-born patients (mean age 62 vs 56years, p<0.001). There were no differences in the proportion of patients who had central chest pain (74.9% vs 75.7%, p=0.526); ambulance utilisation (41.7% vs 41.1%, p=0.697); and time to initial treatment in ED (21 vs 22min, p=0.375). However, CALD patients spent a significantly longer total time in ED (5.4 vs 4.3h, p<0.001). There was no difference in guideline concordance between the two groups with low rates of 12.5% vs 13%, p=0.556. Nonetheless, CALD patients were 22% (95% CI, 0.65, 0.95, p=0.015) less likely to receive the guideline management for chest pain. The initial emergency care was equally provided to all patients in the context of a low rate of concordance with three chest pain related standards from the two guidelines. Nonetheless, CALD patients spent a longer time in ED compared to the Australian-born group. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Reputation drives cooperative behaviour and network formation in human groups.

PubMed

Cuesta, Jose A; Gracia-Lázaro, Carlos; Ferrer, Alfredo; Moreno, Yamir; Sánchez, Angel

2015-01-19

Cooperativeness is a defining feature of human nature. Theoreticians have suggested several mechanisms to explain this ubiquitous phenomenon, including reciprocity, reputation, and punishment, but the problem is still unsolved. Here we show, through experiments conducted with groups of people playing an iterated Prisoner's Dilemma on a dynamic network, that it is reputation what really fosters cooperation. While this mechanism has already been observed in unstructured populations, we find that it acts equally when interactions are given by a network that players can reconfigure dynamically. Furthermore, our observations reveal that memory also drives the network formation process, and cooperators assort more, with longer link lifetimes, the longer the past actions record. Our analysis demonstrates, for the first time, that reputation can be very well quantified as a weighted mean of the fractions of past cooperative acts and the last action performed. This finding has potential applications in collaborative systems and e-commerce.

Reading Function and Content Words in Subtitled Videos.

PubMed

Krejtz, Izabela; Szarkowska, Agnieszka; Łogińska, Maria

2016-04-01

In this study, we examined how function and content words are read in intra- and interlingual subtitles. We monitored eye movements of a group of 39 deaf, 27 hard of hearing, and 56 hearing Polish participants while they viewed English and Polish videos with Polish subtitles. We found that function words and short content words received less visual attention than longer content words, which was reflected in shorter dwell time, lower number of fixations, shorter first fixation duration, and lower subject hit count. Deaf participants dwelled significantly longer on function words than other participants, which may be an indication of their difficulty in processing this type of words. The findings are discussed in the context of classical reading research and applied research on subtitling. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Reputation drives cooperative behaviour and network formation in human groups

PubMed Central

Cuesta, Jose A.; Gracia-Lázaro, Carlos; Ferrer, Alfredo; Moreno, Yamir; Sánchez, Angel

2015-01-01

Cooperativeness is a defining feature of human nature. Theoreticians have suggested several mechanisms to explain this ubiquitous phenomenon, including reciprocity, reputation, and punishment, but the problem is still unsolved. Here we show, through experiments conducted with groups of people playing an iterated Prisoner's Dilemma on a dynamic network, that it is reputation what really fosters cooperation. While this mechanism has already been observed in unstructured populations, we find that it acts equally when interactions are given by a network that players can reconfigure dynamically. Furthermore, our observations reveal that memory also drives the network formation process, and cooperators assort more, with longer link lifetimes, the longer the past actions record. Our analysis demonstrates, for the first time, that reputation can be very well quantified as a weighted mean of the fractions of past cooperative acts and the last action performed. This finding has potential applications in collaborative systems and e-commerce. PMID:25598347

Creating Learning Environments in the Early Grades That Support Teacher and Student Success: Profiles of Effective Practices in Three Expanded Learning Time Schools

ERIC Educational Resources Information Center

Farbman, David A.; Novoryta, Ami

2016-01-01

In "Creating Learning Environments in the Early Grades that Support Teacher and Student Success," the National Center on Time & Learning (NCTL) profiles three expanded-time elementary schools that leverage a longer school day to better serve young students. In particular, the report describes how a longer day opens up opportunities…

Design of container velocity profile for the suppression of liquid sloshing

NASA Astrophysics Data System (ADS)

Kim, Dongjoo

2016-11-01

In many industrial applications, high-speed position control of a liquid container causes undesirable liquid vibrations called 'sloshing' which poses a control challenge in fast maneuvering and accurate positioning of containers. Recently, it has been shown that a control theory called 'input shaping' is successfully applied to reduce the sloshing, but its success comes at a cost of longer process time. Therefore, we aim to minimize liquid sloshing without increasing the process time when a container moves horizontally by a target distance within a limited time. In this study, sensing and feedback actuation are not permitted but the container velocity is allowed to be modified from a given triangular profile. A new design is proposed by applying input shaping to the container velocity with carefully selected acceleration time. That is, the acceleration time is chosen to be the 1st mode natural period, and the input shaper is determined based on the 3rd mode natural frequency. The proposed approach is validated by performing numerical simulations, which show that the simple modification of container velocity reduces the sloshing significantly without additional process time in a feedforward manner. Supported by the NRF programs (NRF-2015R1D1A1A01059675) of Korean government.

How does processing affect storage in working memory tasks? Evidence for both domain-general and domain-specific effects.

PubMed

Jarrold, Christopher; Tam, Helen; Baddeley, Alan D; Harvey, Caroline E

2011-05-01

Two studies that examine whether the forgetting caused by the processing demands of working memory tasks is domain-general or domain-specific are presented. In each, separate groups of adult participants were asked to carry out either verbal or nonverbal operations on exactly the same processing materials while maintaining verbal storage items. The imposition of verbal processing tended to produce greater forgetting even though verbal processing operations took no longer to complete than did nonverbal processing operations. However, nonverbal processing did cause forgetting relative to baseline control conditions, and evidence from the timing of individuals' processing responses suggests that individuals in both processing groups slowed their responses in order to "refresh" the memoranda. Taken together the data suggest that processing has a domain-general effect on working memory performance by impeding refreshment of memoranda but can also cause effects that appear domain-specific and that result from either blocking of rehearsal or interference.

The Effect of Nitrogen and Titanium on the Toughness of High Strength Saw Weld Deposits

DTIC Science & Technology

1989-05-12

2.3 CCT diagram for typical SAW steel welds [8]. 26 Figure 2.4 Oxygen and nitrogen levels expected from several arc 31 welding processes [10]. Figure...alloyed ferritic weld metal such formation is achieved if the CCT diagram is displaced towards longer times. However, it is worth noting that too large...dilution and cooling rate [5]. In this context, the CCT diagram is often used to denote the transformations that occur in weld metal samples which

To develop a spectral analyzer for physiological and medical use

NASA Technical Reports Server (NTRS)

Iberall, A.; Cardon, S.; Weinberg, M.; Schindler, A.

1971-01-01

Scientific requirements necessary to develop a spectral analyzer for monitoring mammalian subjects, are discussed. The analyzer measures dynamic or time dependent data as a measure of the subjects operating status. Measurable data include metabolic rate, body temperature, and blood constituents like glucose, oxygen, and carbon dioxide, and lactic acid. Metabolic cycles were found with periodicities in the range of minutes and hours; longer cycles in body weight (3 1/2 days and 60 days), indicative of metabolic processes, were also found.

Dynamics of soil CO 2 efflux under varying atmospheric CO 2 concentrations reveal dominance of slow processes

Treesearch

Dohyoung Kim; Ram Oren; James S. Clark; Sari Palmroth; A. Christopher Oishi; Heather R. McCarthy; Chris A. Maier; Kurt Johnsen

2017-01-01

We evaluated the effect on soil CO2 efflux (FCO2) of sudden changes in photosynthetic rates by altering CO2 concentration in plots subjected to +200 ppmv for 15 years. Five-day intervals of exposure to elevated CO2 (eCO2) ranging 1.0–1.8 times ambient did not affect FCO2. FCO2 did not decrease until 4 months after termination of the long-term eCO2 treatment, longer...

Air and Water Processes Do Not Produce the Same High-Quality Pasteurization of Donor Human Milk.

PubMed

Buffin, Rachel; Pradat, Pierre; Trompette, Jocelyne; Ndiaye, Isabelle; Basson, Eliane; Jordan, Isabelle; Picaud, Jean-Charles

2017-11-01

Holder pasteurization is the most commonly used technique in milk banks worldwide, but higher temperatures and longer pasteurization time have been associated with damage to the immune components of human milk. Research aim: This study aimed to assess the detailed pattern of pasteurization temperature using two water pasteurizers (WP1 and WP2) and one air pasteurizer (AP). The milk temperature during each phase of the pasteurization cycle was recorded using 6 to 9 probes, depending on the number of bottles, in the pasteurizers. We used 90 to 200 ml bottles to assess the effect of volume on milk temperature. The time to heat the milk from room temperature to 58°C was 12.4, 12.9, and 64.5 min, respectively, for WP1, WP2, and the AP ( p < .0001). The duration of the plateau was 35.5, 35.2, and 45.8 min ( p < .0001). The duration of exposure to a temperature above 58°C was 49.6, 40.7, and 76.2 min ( p < .0001). The total duration of a full cycle was 79, 66, and 182 min ( p < .0001). The duration of exposure above 58°C for the different volumes of milk treated showed no difference when using WP1 but was significantly longer in small volumes when using WP2. Human milk treated using the air pasteurizer in our study was exposed to higher temperatures and for longer periods of time than the water pasteurizers we employed. Regular qualification of pasteurizers is requested when evaluating the effect of pasteurization on milk components and for routine treatment of human milk in milk banks.

How can we deal with ANN in flood forecasting? As a simulation model or updating kernel!

NASA Astrophysics Data System (ADS)

Hassan Saddagh, Mohammad; Javad Abedini, Mohammad

2010-05-01

Flood forecasting and early warning, as a non-structural measure for flood control, is often considered to be the most effective and suitable alternative to mitigate the damage and human loss caused by flood. Forecast results which are output of hydrologic, hydraulic and/or black box models should secure accuracy of flood values and timing, especially for long lead time. The application of the artificial neural network (ANN) in flood forecasting has received extensive attentions in recent years due to its capability to capture the dynamics inherent in complex processes including flood. However, results obtained from executing plain ANN as simulation model demonstrate dramatic reduction in performance indices as lead time increases. This paper is intended to monitor the performance indices as it relates to flood forecasting and early warning using two different methodologies. While the first method employs a multilayer neural network trained using back-propagation scheme to forecast output hydrograph of a hypothetical river for various forecast lead time up to 6.0 hr, the second method uses 1D hydrodynamic MIKE11 model as forecasting model and multilayer neural network as updating kernel to monitor and assess the performance indices compared to ANN alone in light of increase in lead time. Results presented in both graphical and tabular format indicate superiority of MIKE11 coupled with ANN as updating kernel compared to ANN as simulation model alone. While plain ANN produces more accurate results for short lead time, the errors increase expeditiously for longer lead time. The second methodology provides more accurate and reliable results for longer forecast lead time.

Dynamic-Type Ice Thermal Storage Systems

NASA Astrophysics Data System (ADS)

Ohira, Akiyoshi

This paper deals with reviews for research and development of a dynamic-type ice thermal storage system. This system has three main features. First, the ice thermal storage tank and the ice generator are separate. Second, ice is transported to the tank from the ice generator by water or air. Third, the ice making and melting processes are operated at the same time. Outlet water temperature from the dynamic-type ice thermal storage tank remains low for a longer time. In this paper, dynamic-Type ice thermal storage systems are divided into three parts: the ice making part, the ice transport part, and the cold energy release part. Each part is reviewed separately.

Stabilization and Structure of wave packets in Rydberg atoms ionized by a strong light field.

PubMed

Fedorov, M; Fedorov, S

1998-09-28

New features of the phenomenon of interference stabilization of Rydberg atoms are found to exist. The main of them are: (i) dynamical stabilization, which means that in case of pulses with a smooth envelope the time-dependent residual probability for an atom to survive in bound states remains almost constant in the middle part of a pulse (at the strongest fields); (ii) existence of the strong-field stabilization of the after-pulse residual probability in case of pulses longer than the classical Kepler period; and (iii) pulsation of the time-dependent Rydberg wave packet formed in the process of photoionization.

Acute Stress Dysregulates the LPP ERP Response to Emotional Pictures and Impairs Sustained Attention: Time-Sensitive Effects

PubMed Central

Alomari, Rima A.; Fernandez, Mercedes; Banks, Jonathan B.; Acosta, Juliana; Tartar, Jaime L.

2015-01-01

Stress can increase emotional vigilance at the cost of a decrease in attention towards non-emotional stimuli. However, the time-dependent effects of acute stress on emotion processing are uncertain. We tested the effects of acute stress on subsequent emotion processing up to 40 min following an acute stressor. Our measure of emotion processing was the late positive potential (LPP) component of the visual event-related potential (ERP), and our measure of non-emotional attention was the sustained attention to response task (SART). We also measured cortisol levels before and after the socially evaluated cold pressor test (SECPT) induction. We found that the effects of stress on the LPP ERP emotion measure were time sensitive. Specifically, the LPP ERP was only altered in the late time-point (30–40 min post-stress) when cortisol was at its highest level. Here, the LPP no longer discriminated between the emotional and non-emotional picture categories, most likely because neutral pictures were perceived as emotional. Moreover, compared to the non-stress condition, the stress-condition showed impaired performance on the SART. Our results support the idea that a limit in attention resources after an emotional stressor is associated with the brain incorrectly processing non-emotional stimuli as emotional and interferes with sustained attention. PMID:26010485

Image Corruption Detection in Diffusion Tensor Imaging for Post-Processing and Real-Time Monitoring

PubMed Central

Li, Yue; Shea, Steven M.; Lorenz, Christine H.; Jiang, Hangyi; Chou, Ming-Chung; Mori, Susumu

2013-01-01

Due to the high sensitivity of diffusion tensor imaging (DTI) to physiological motion, clinical DTI scans often suffer a significant amount of artifacts. Tensor-fitting-based, post-processing outlier rejection is often used to reduce the influence of motion artifacts. Although it is an effective approach, when there are multiple corrupted data, this method may no longer correctly identify and reject the corrupted data. In this paper, we introduce a new criterion called “corrected Inter-Slice Intensity Discontinuity” (cISID) to detect motion-induced artifacts. We compared the performance of algorithms using cISID and other existing methods with regard to artifact detection. The experimental results show that the integration of cISID into fitting-based methods significantly improves the retrospective detection performance at post-processing analysis. The performance of the cISID criterion, if used alone, was inferior to the fitting-based methods, but cISID could effectively identify severely corrupted images with a rapid calculation time. In the second part of this paper, an outlier rejection scheme was implemented on a scanner for real-time monitoring of image quality and reacquisition of the corrupted data. The real-time monitoring, based on cISID and followed by post-processing, fitting-based outlier rejection, could provide a robust environment for routine DTI studies. PMID:24204551

Acute Stress Dysregulates the LPP ERP Response to Emotional Pictures and Impairs Sustained Attention: Time-Sensitive Effects.

PubMed

Alomari, Rima A; Fernandez, Mercedes; Banks, Jonathan B; Acosta, Juliana; Tartar, Jaime L

2015-05-20

Stress can increase emotional vigilance at the cost of a decrease in attention towards non-emotional stimuli. However, the time-dependent effects of acute stress on emotion processing are uncertain. We tested the effects of acute stress on subsequent emotion processing up to 40 min following an acute stressor. Our measure of emotion processing was the late positive potential (LPP) component of the visual event-related potential (ERP), and our measure of non-emotional attention was the sustained attention to response task (SART). We also measured cortisol levels before and after the socially evaluated cold pressor test (SECPT) induction. We found that the effects of stress on the LPP ERP emotion measure were time sensitive. Specifically, the LPP ERP was only altered in the late time-point (30-40 min post-stress) when cortisol was at its highest level. Here, the LPP no longer discriminated between the emotional and non-emotional picture categories, most likely because neutral pictures were perceived as emotional. Moreover, compared to the non-stress condition, the stress-condition showed impaired performance on the SART. Our results support the idea that a limit in attention resources after an emotional stressor is associated with the brain incorrectly processing non-emotional stimuli as emotional and interferes with sustained attention.

Early chemo-dynamical evolution of dwarf galaxies deduced from enrichment of r-process elements

NASA Astrophysics Data System (ADS)

Hirai, Yutaka; Ishimaru, Yuhri; Saitoh, Takayuki R.; Fujii, Michiko S.; Hidaka, Jun; Kajino, Toshitaka

2017-04-01

The abundance of elements synthesized by the rapid neutron-capture process (r-process elements) of extremely metal-poor (EMP) stars in the Local Group galaxies gives us clues to clarify the early evolutionary history of the Milky Way halo. The Local Group dwarf galaxies would have similarly evolved with building blocks of the Milky Way halo. However, how the chemo-dynamical evolution of the building blocks affects the abundance of r-process elements is not yet clear. In this paper, we perform a series of simulations using dwarf galaxy models with various dynamical times and total mass, which determine star formation histories. We find that galaxies with dynamical times longer than 100 Myr have star formation rates less than 10-3 M⊙ yr-1 and slowly enrich metals in their early phase. These galaxies can explain the observed large scatters of r-process abundance in EMP stars in the Milky Way halo regardless of their total mass. On the other hand, the first neutron star merger appears at a higher metallicity in galaxies with a dynamical time shorter than typical neutron star merger times. The scatters of r-process elements mainly come from the inhomogeneity of the metals in the interstellar medium whereas the scatters of α-elements are mostly due to the difference in the yield of each supernova. Our results demonstrate that the future observations of r-process elements in EMP stars will be able to constrain the early chemo-dynamical evolution of the Local Group galaxies.

Neural stem cell differentiation by electrical stimulation using a cross-linked PEDOT substrate: Expanding the use of biocompatible conjugated conductive polymers for neural tissue engineering.

PubMed

Pires, Filipa; Ferreira, Quirina; Rodrigues, Carlos A V; Morgado, Jorge; Ferreira, Frederico Castelo

2015-06-01

The use of conjugated polymers allows versatile interactions between cells and flexible processable materials, while providing a platform for electrical stimulation, which is particularly relevant when targeting differentiation of neural stem cells and further application for therapy or drug screening. Materials were tested for cytotoxicity following the ISO10993-5. PSS was cross-linked. ReNcellVM neural stem cells (NSC) were seeded in laminin coated surfaces, cultured for 4 days in the presence of EGF (20 ng/mL), FGF-2 (20 ng/mL) and B27 (20 μg/mL) and differentiated over eight additional days in the absence of those factors under 100Hz pulsed DC electrical stimulation, 1V with 10 ms pulses. NSC and neuron elongation aspect ratio as well as neurite length were assessed using ImageJ. Cells were immune-stained for Tuj1 and GFAP. F8T2, MEH-PPV, P3HT and cross-linked PSS (x PSS) were assessed as non-cytotoxic. L929 fibroblast population was 1.3 higher for x PSS than for glass control, while F8T2 presents moderate proliferation. The population of neurons (Tuj1) was 1.6 times higher with longer neurites (73 vs 108 μm) for cells cultured under electrical stimulus, with cultured NSC. Such stimulus led also to longer neurons. x PSS was, for the first time, used to elongate human NSC through the application of pulsed current, impacting on their differentiation towards neurons and contributing to longer neurites. The range of conductive conjugated polymers known as non-cytotoxic was expanded. x PSS was introduced as a stable material, easily processed from solution, to interface with biological systems, in particular NSC, without the need of in-situ polymerization. Copyright © 2015 Elsevier B.V. All rights reserved.

Investigation of the effect of power ultrasound on the nucleation of water during freezing of agar gel samples in tubing vials.

PubMed

Kiani, Hossein; Sun, Da-Wen; Delgado, Adriana; Zhang, Zhihang

2012-05-01

Nucleation, as an important stage of freezing process, can be induced by the irradiation of power ultrasound. In this study, the effect of irradiation temperature (-2 °C, -3 °C, -4 °C and -5 °C), irradiation duration (0s, 1s, 3s, 5s, 10s or 15s) and ultrasound intensity (0.07 W cm(-2), 0.14 W cm(-2), 0.25 W cm(-2), 0.35 W cm(-2) and 0.42 W cm(-2)) on the dynamic nucleation of ice in agar gel samples was studied. The samples were frozen in an ethylene glycol-water mixture (-20 °C) in an ultrasonic bath system after putting them into tubing vials. Results indicated that ultrasound irradiation is able to initiate nucleation at different supercooled temperatures (from -5 °C to -2 °C) in agar gel if optimum intensity and duration of ultrasound were chosen. Evaluation of the effect of 0.25 W cm(-2) ultrasound intensity and different durations of ultrasound application on agar gels showed that 1s was not long enough to induce nucleation, 3s induced the nucleation repeatedly but longer irradiation durations resulted in the generation of heat and therefore nucleation was postponed. Investigation of the effect of ultrasound intensity revealed that higher intensities of ultrasound were effective when a shorter period of irradiation was used, while lower intensities only resulted in nucleation when a longer irradiation time was applied. In addition to this, higher intensities were not effective at longer irradiation times due to the heat generated in the samples by the heating effect of ultrasound. In conclusion, the use of ultrasound as a means to control the crystallization process offers promising application in freezing of solid foods, however, optimum conditions should be selected. Copyright © 2011 Elsevier B.V. All rights reserved.

Climate is changing, everything is flowing, stationarity is immortal

NASA Astrophysics Data System (ADS)

Koutsoyiannis, Demetris; Montanari, Alberto

2015-04-01

There is no doubt that climate is changing -- and ever has been. The environment is also changing and in the last decades, as a result of demographic change and technological advancement, environmental change has been accelerating. These affect also the hydrological processes, whose changes in connection with rapidly changing human systems have been the focus of the new scientific decade 2013-2022 of the International Association of Hydrological Sciences, entitled "Panta Rhei - Everything Flows". In view of the changing systems, it has recently suggested that, when dealing with water management and hydrological extremes, stationarity is no longer a proper assumption. Hence, it was proposed that hydrological processes should be treated as nonstationary. Two main reasons contributed to this perception. First, the climate models project a future hydroclimate that will be different from the current one. Second, as streamflow record become longer, they indicate the presence of upward or downward trends. However, till now hydroclimatic projections made in the recent past have not been verified. At the same time, evidence from quite longer records, instrumental or proxy, suggest that local trends are omnipresent but not monotonic; rather at some time upward trends turn to downward ones and vice versa. These observations suggest that improvident dismiss of stationarity and adoption of nonstationary descriptions based either on climate model outputs or observed trends may entail risks. The risks stem from the facts that the future can be different from what was deterministically projected, that deterministic projections are associated with an illusion of decreased uncertainty, as well as that nonstationary models fitted on observed data may have lower predictive capacity than simpler stationary ones. In most of the cases, what is actually needed is to revisit the concept of stationarity and try to apply it carefully, making it consistent with the presence of local trends, possibly incorporating information from deterministic predictions, whenever these prove to be reliable, and estimating the total predictive uncertainty.

The role of dopamine in the timing of Pavlovian conditioned keypecking in ring doves.

PubMed

Ohyama, T; Horvitz, J C; Kitsos, E; Balsam, P D

2001-01-01

The effect of dopaminergic drugs on the timing of conditioned keypecking in ring doves was studied in two experiments. Subjects were given pairings of a keylight with food and the temporal distribution of keypecks was obtained during unreinforced probe trials. Experiment 1 demonstrated that injections of pimozide before each session immediately decreased response rates but shifted timing distributions gradually to the right over several days of treatment. Experiment 2 showed similar results using a longer interstimulus interval (ISI). No shifts were observed when the drug was injected after training sessions, or when a delay, identical to each subject's average latency to eat during the drug condition, was inserted between keylight offset and food presentation. Consequently, the shifts in timing were mediated neither by mere accumulation of the drug nor a delay from keylight offset to food presentation resulting from the drug's ability to slow motor processes. The results suggest that pimozide modulates response rate through its effect on motor processes or incentive value, and response timing through a conditioned response (CR) to injection-related cues established via their repeated pairings with the drug.

Melting dynamics of ice in the mesoscopic regime

PubMed Central

Citroni, Margherita; Fanetti, Samuele; Falsini, Naomi; Foggi, Paolo; Bini, Roberto

2017-01-01

How does a crystal melt? How long does it take for melt nuclei to grow? The melting mechanisms have been addressed by several theoretical and experimental works, covering a subnanosecond time window with sample sizes of tens of nanometers and thus suitable to determine the onset of the process but unable to unveil the following dynamics. On the other hand, macroscopic observations of phase transitions, with millisecond or longer time resolution, account for processes occurring at surfaces and time limited by thermal contact with the environment. Here, we fill the gap between these two extremes, investigating the melting of ice in the entire mesoscopic regime. A bulk ice Ih or ice VI sample is homogeneously heated by a picosecond infrared pulse, which delivers all of the energy necessary for complete melting. The evolution of melt/ice interfaces thereafter is monitored by Mie scattering with nanosecond resolution, for all of the time needed for the sample to reequilibrate. The growth of the liquid domains, over distances of micrometers, takes hundreds of nanoseconds, a time orders of magnitude larger than expected from simple H-bond dynamics. PMID:28536197

Two dimensional kinetic analysis of electrostatic harmonic plasma waves

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fonseca-Pongutá, E. C.; Ziebell, L. F.; Gaelzer, R.

2016-06-15

Electrostatic harmonic Langmuir waves are virtual modes excited in weakly turbulent plasmas, first observed in early laboratory beam-plasma experiments as well as in rocket-borne active experiments in space. However, their unequivocal presence was confirmed through computer simulated experiments and subsequently theoretically explained. The peculiarity of harmonic Langmuir waves is that while their existence requires nonlinear response, their excitation mechanism and subsequent early time evolution are governed by essentially linear process. One of the unresolved theoretical issues regards the role of nonlinear wave-particle interaction process over longer evolution time period. Another outstanding issue is that existing theories for these modes aremore » limited to one-dimensional space. The present paper carries out two dimensional theoretical analysis of fundamental and (first) harmonic Langmuir waves for the first time. The result shows that harmonic Langmuir wave is essentially governed by (quasi)linear process and that nonlinear wave-particle interaction plays no significant role in the time evolution of the wave spectrum. The numerical solutions of the two-dimensional wave spectra for fundamental and harmonic Langmuir waves are also found to be consistent with those obtained by direct particle-in-cell simulation method reported in the literature.« less

The Effect of Interruption Duration and Demand on Resuming Suspended Goals

ERIC Educational Resources Information Center

Monk, Christopher A.; Trafton, J. Gregory; Boehm-Davis, Deborah A.

2008-01-01

The time to resume task goals after an interruption varied depending on the duration and cognitive demand of interruptions, as predicted by the memory for goals model (Altmann & Trafton, 2002). Three experiments using an interleaved tasks interruption paradigm showed that longer and more demanding interruptions led to longer resumption times in a…

Fast but not intuitive, slow but not reflective: Decision conflict drives reaction times in social dilemmas.

PubMed

Evans, Anthony M; Dillon, Kyle D; Rand, David G

2015-10-01

When people have the chance to help others at a cost to themselves, are cooperative decisions driven by intuition or reflection? To answer this question, recent studies have tested the relationship between reaction times (RTs) and cooperation, reporting both positive and negative correlations. To reconcile this apparent contradiction, we argue that decision conflict (rather than the use of intuition vs. reflection) drives response times, leading to an inverted-U shaped relationship between RT and cooperation. Studies 1 through 3 show that intermediate decisions take longer than both extremely selfish and extremely cooperative decisions. Studies 4 and 5 find that the conflict between self-interested and cooperative motives explains individual differences in RTs. Manipulating conflictedness causes longer RTs and more intermediate decisions, and RTs mediate the relationship between conflict and intermediate decisions. Finally, Studies 6 and 7 demonstrate that conflict is distinct from reflection by manipulating the use of intuition (vs. reflection). Experimentally promoting reliance on intuition increases cooperation, but has no effects on decision extremity or feelings of conflictedness. In sum, we provide evidence that RTs should not be interpreted as a direct proxy for the use of intuitive or reflective processes, and dissociate the effects of conflict and reflection in social decision making. (c) 2015 APA, all rights reserved).

Femtosecond to nanosecond excited state dynamics of vapor deposited copper phthalocyanine thin films.

PubMed

Caplins, Benjamin W; Mullenbach, Tyler K; Holmes, Russell J; Blank, David A

2016-04-28

Vapor deposited thin films of copper phthalocyanine (CuPc) were investigated using transient absorption spectroscopy. Exciton-exciton annihilation dominated the kinetics at high exciton densities. When annihilation was minimized, the observed lifetime was measured to be 8.6 ± 0.6 ns, which is over an order of magnitude longer than previous reports. In comparison with metal free phthalocyanine (H2Pc), the data show evidence that the presence of copper induces an ultrafast relaxation process taking place on the ca. 500 fs timescale. By comparison to recent time-resolved photoemission studies, this is assigned as ultrafast intersystem crossing. As the intersystem crossing occurs ca. 10(4) times faster than lifetime decay, it is likely that triplets are the dominant excitons in vapor deposited CuPc films. The exciton lifetime of CuPc thin films is ca. 35 times longer than H2Pc thin films, while the diffusion lengths reported in the literature are typically quite similar for the two materials. These findings suggest that despite appearing to be similar materials at first glance, CuPc and H2Pc may transport energy in dramatically different ways. This has important implications on the design and mechanistic understanding of devices where phthalocyanines are used as an excitonic material.

Time and decision making: differential contribution of the posterior insular cortex and the striatum during a delay discounting task.

PubMed

Wittmann, Marc; Leland, David S; Paulus, Martin P

2007-06-01

Delay discounting refers to the fact that an immediate reward is valued more than the same reward if it occurs some time in the future. To examine the neural substrates underlying this process, we studied 13 healthy volunteers who repeatedly had to decide between an immediate and parametrically varied delayed hypothetical reward using a delay discounting task during event-related functional magnetic resonance imaging. Subject's preference judgments resulted in different discounting slopes for shorter (<1 year) and for longer (> or =1 year) delays. Neural activation associated with the shorter delays relative to the longer delays was associated with increased activation in the head of the left caudate nucleus and putamen. When individuals selected the delayed relative to the immediate reward, a strong activation was found in bilateral posterior insular cortex. Several brain areas including the left caudate nucleus showed a correlation between the behaviorally determined discounting and brain activation for the contrast of intervals with delays <1 and > or =1 year. These results suggest that (1) the posterior insula, which is a critical component of the decision-making neural network, is involved in delaying gratification and (2) the degree of neural activation in the striatum, which plays a fundamental role in reward prediction and in time estimation, may code for the time delay.

[Metaplasic Paneth cells in ulcerative colitis].

PubMed

Bedini, Oscar Alfredo; Naves, Ariel; San Miguel, Patricia; Quispe, Arturo; Guida, Carolina

2014-01-01

Paneth cells are normally present in small intestine, but its appearance in other areas of the gastrointestinal tract is related to chronic inflammatory processes. In our study we retrospectively examined 29 patients with diagnosis of ulcerative colitis, from the files of Instituto de Histopatología de Rosario, and from the casuistry of two authors (O.B. and P.S.M.), during two years. Biopsies corresponded to rectal or sigmoid mucosa and were stained with H.E. Distal Paneth cells in rectum and/or sigmoid colon were found in 60% of patients. This finding was related to the time of evolution of the disease (median 7 years for patients with Paneth cells and 3 years for patients without Paneth cells). With more time of evolution, there were more number of affected crypts and more number of Paneth cells. Some of the patients with longer evolution had 2-5 crypts with Paneth cells (up to 11 Paneth cells). When the time of evolution of the disease was longer, we found an irregular distribution of Paneth cells, with migration from the depth of the crypt to highest crypt levels. There was a relationship between the number of Paneth cells and the degree of leukocyte infiltration of the mucosa. We observed a direct correlation of the presence of Paneth cells with the time of evolution of the disease and with the leukocyte infiltration of the mucosa.

Outpatient Office Wait Times and Quality of Care for Medicaid Patients

PubMed Central

Oostrom, Tamar; Einav, Liran; Finkelstein, Amy

2018-01-01

Time spent in the doctor’s waiting room captures an important aspect of the healthcare experience. We analyzed data on 21 million outpatient visits obtained from electronic health record systems, allowing us to measure time spent in the waiting room beyond the scheduled appointment time. Median wait time was just over 4 minutes. Almost one-fifth of visits had waits longer than 20 minutes, and 10% were over 30 minutes. Waits were shorter for early morning appointments, younger patients, and at larger practices. Median wait time was 4.1 minutes for privately-insured and 4.6 minutes for Medicaid patients; adjusting for patient and appointment characteristics, Medicaid patients were 20% more likely than the privately-insured to wait longer than 20 minutes (P<0.001), with most of this disparity explained by differences in practices and providers they saw. Wait time for Medicaid patients relative to the privately-insured was longer in states with relatively lower Medicaid reimbursement rates. PMID:28461348

Typical visual search performance and atypical gaze behaviors in response to faces in Williams syndrome.

PubMed

Hirai, Masahiro; Muramatsu, Yukako; Mizuno, Seiji; Kurahashi, Naoko; Kurahashi, Hirokazu; Nakamura, Miho

2016-01-01

Evidence indicates that individuals with Williams syndrome (WS) exhibit atypical attentional characteristics when viewing faces. However, the dynamics of visual attention captured by faces remain unclear, especially when explicit attentional forces are present. To clarify this, we introduced a visual search paradigm and assessed how the relative strength of visual attention captured by a face and explicit attentional control changes as search progresses. Participants (WS and controls) searched for a target (butterfly) within an array of distractors, which sometimes contained an upright face. We analyzed reaction time and location of the first fixation-which reflect the attentional profile at the initial stage-and fixation durations. These features represent aspects of attention at later stages of visual search. The strength of visual attention captured by faces and explicit attentional control (toward the butterfly) was characterized by the frequency of first fixations on a face or butterfly and on the duration of face or butterfly fixations. Although reaction time was longer in all groups when faces were present, and visual attention was not dominated by faces in any group during the initial stages of the search, when faces were present, attention to faces dominated in the WS group during the later search stages. Furthermore, for the WS group, reaction time correlated with eye-movement measures at different stages of searching such that longer reaction times were associated with longer face-fixations, specifically at the initial stage of searching. Moreover, longer reaction times were associated with longer face-fixations at the later stages of searching, while shorter reaction times were associated with longer butterfly fixations. The relative strength of attention captured by faces in people with WS is not observed at the initial stage of searching but becomes dominant as the search progresses. Furthermore, although behavioral responses are associated with some aspects of eye movements, they are not as sensitive as eye-movement measurements themselves at detecting atypical attentional characteristics in people with WS.

The Time-Course of Ultrarapid Categorization: The Influence of Scene Congruency and Top-Down Processing.

PubMed

Vanmarcke, Steven; Calders, Filip; Wagemans, Johan

2016-01-01

Although categorization can take place at different levels of abstraction, classic studies on semantic labeling identified the basic level, for example, dog, as entry point for categorization. Ultrarapid categorization tasks have contradicted these findings, indicating that participants are faster at detecting superordinate-level information, for example, animal, in a complex visual image. We argue that both seemingly contradictive findings can be reconciled within the framework of parallel distributed processing and its successor Leabra (Local, Error-driven and Associative, Biologically Realistic Algorithm). The current study aimed at verifying this prediction in an ultrarapid categorization task with a dynamically changing presentation time (PT) for each briefly presented object, followed by a perceptual mask. Furthermore, we manipulated two defining task variables: level of categorization (basic vs. superordinate categorization) and object presentation mode (object-in-isolation vs. object-in-context). In contradiction with previous ultrarapid categorization research, focusing on reaction time, we used accuracy as our main dependent variable. Results indicated a consistent superordinate processing advantage, coinciding with an overall improvement in performance with longer PT and a significantly more accurate detection of objects in isolation, compared with objects in context, at lower stimulus PT. This contextual disadvantage disappeared when PT increased, indicating that figure-ground separation with recurrent processing is vital for meaningful contextual processing to occur.

The Time-Course of Ultrarapid Categorization: The Influence of Scene Congruency and Top-Down Processing

PubMed Central

Calders, Filip; Wagemans, Johan

2016-01-01

Although categorization can take place at different levels of abstraction, classic studies on semantic labeling identified the basic level, for example, dog, as entry point for categorization. Ultrarapid categorization tasks have contradicted these findings, indicating that participants are faster at detecting superordinate-level information, for example, animal, in a complex visual image. We argue that both seemingly contradictive findings can be reconciled within the framework of parallel distributed processing and its successor Leabra (Local, Error-driven and Associative, Biologically Realistic Algorithm). The current study aimed at verifying this prediction in an ultrarapid categorization task with a dynamically changing presentation time (PT) for each briefly presented object, followed by a perceptual mask. Furthermore, we manipulated two defining task variables: level of categorization (basic vs. superordinate categorization) and object presentation mode (object-in-isolation vs. object-in-context). In contradiction with previous ultrarapid categorization research, focusing on reaction time, we used accuracy as our main dependent variable. Results indicated a consistent superordinate processing advantage, coinciding with an overall improvement in performance with longer PT and a significantly more accurate detection of objects in isolation, compared with objects in context, at lower stimulus PT. This contextual disadvantage disappeared when PT increased, indicating that figure-ground separation with recurrent processing is vital for meaningful contextual processing to occur. PMID:27803794

Specimen origin, type and testing laboratory are linked to longer turnaround times for HIV viral load testing in Malawi

PubMed Central

Chipungu, Geoffrey; Kim, Andrea A.; Sarr, Abdoulaye; Ali, Hammad; Mwenda, Reuben; Nkengasong, John N.; Singer, Daniel

2017-01-01

Background Efforts to reach UNAIDS’ treatment and viral suppression targets have increased demand for viral load (VL) testing and strained existing laboratory networks, affecting turnaround time. Longer VL turnaround times delay both initiation of formal adherence counseling and switches to second-line therapy for persons failing treatment and contribute to poorer health outcomes. Methods We utilized descriptive statistics and logistic regression to analyze VL testing data collected in Malawi between January 2013 and March 2016. The primary outcomes assessed were greater-than-median pretest phase turnaround time (days elapsed from specimen collection to receipt at the laboratory) and greater-than-median test phase turnaround time (days from receipt to testing). Results The median number of days between specimen collection and testing increased 3-fold between 2013 (8 days, interquartile range (IQR) = 6–16) and 2015 (24, IQR = 13–39) (p<0.001). Multivariable analysis indicated that the odds of longer pretest phase turnaround time were significantly higher for specimen collection districts without laboratories capable of conducting viral load tests (adjusted odds ratio (aOR) = 5.16; 95% confidence interval (CI) = 5.04–5.27) as well as for Malawi’s Northern and Southern regions. Longer test phase turnaround time was significantly associated with use of dried blood spots instead of plasma (aOR = 2.30; 95% CI = 2.23–2.37) and for certain testing months and testing laboratories. Conclusion Increased turnaround time for VL testing appeared to be driven in part by categorical factors specific to the phase of turnaround time assessed. Given the implications of longer turnaround time and the global effort to scale up VL testing, addressing these factors via increasing efficiencies, improving quality management systems and generally strengthening the VL spectrum should be considered essential components of controlling the HIV epidemic. PMID:28235013

Pitting temporal against spatial integration in schizophrenic patients.

PubMed

Herzog, Michael H; Brand, Andreas

2009-06-30

Schizophrenic patients show strong impairments in visual backward masking possibly caused by deficits on the early stages of visual processing. The underlying aberrant mechanisms are not clearly understood. Spatial as well as temporal processing deficits have been proposed. Here, by combining a spatial with a temporal integration paradigm, we show further evidence that temporal but not spatial processing is impaired in schizophrenic patients. Eleven schizophrenic patients and ten healthy controls were presented with sequences composed of Vernier stimuli. Patients needed significantly longer presentation times for sequentially presented Vernier stimuli to reach a performance level comparable to that of healthy controls (temporal integration deficit). When we added spatial contextual elements to some of the Vernier stimuli, performance changed in a complex but comparable manner in patients and controls (intact spatial integration). Hence, temporal but not spatial processing seems to be deficient in schizophrenia.

The association between time scarcity, sociodemographic correlates and consumption of ultra-processed foods among parents in Norway: a cross-sectional study.

PubMed

Djupegot, Ingrid Laukeland; Nenseth, Camilla Bengtson; Bere, Elling; Bjørnarå, Helga Birgit Torgeirsdotter; Helland, Sissel Heidi; Øverby, Nina Cecilie; Torstveit, Monica Klungland; Stea, Tonje Holte

2017-05-15

Use of ultra-processed foods has expanded rapidly over the last decades and high consumption has been positively associated with risk of e.g. overweight, obesity and type 2 diabetes. Ultra-processed foods offer convenience as they require minimal time for preparation. It is therefore reasonable to assume that such foods are consumed more often among people who experience time scarcity. The main aim of this study was to investigate the association between time scarcity and consumption of ultra-processed foods among parents of 2-year olds in Norway. A secondary aim was to investigate the association between sociodemographic correlates, weight status and consumption of ultra-processed foods. This cross-sectional study included 497 participants. Chi-square and cross tabulations were used to calculate proportions of high vs. low consumption of ultra-processed foods in relation to time scarcity, sociodemographic correlates and weight status. Binary logistic regression analyses were performed to test the relationship between independent variables and consumption of ultra-processed foods. Participants reporting medium and high time scarcity were more likely to have a high consumption of ultra-processed dinner products (OR = 3. 68, 95% CI = 2. 32-5.84 and OR = 3.10, 1.80-5.35, respectively) and fast foods (OR = 2.60, 1.62-4.18 and OR = 1.90, 1.08-3.32, respectively) compared to those with low time scarcity. Further, participants with medium time scarcity were more likely to have a high consumption of snacks and soft drinks compared to participants with low time scarcity (OR = 1.63, 1.06-2.49). Finally, gender, ethnicity, educational level, number of children in the household and weight status were identified as important factors associated with the consumption of certain types of ultra-processed foods. Results from the present study showed that time scarcity, various sociodemographic factors and weight status was associated with consumption of processed foods. Future studies with a longitudinal design are needed to further explore these patterns over a longer period of time.

Time and interference: Effects on working memory.

PubMed

Botto, Marta; Palladino, Paola

2016-05-01

This study tested predictions from the time-based resource-sharing (TBRS) model with a classical verbal working memory (WM) task, where target and non-target information interfere strongly with each other. Different predictions can be formulated according to the dominant perspectives (TBRS and interference hypothesis) on the role of inhibitory control in WM task performance. Here, we aimed to trace the activation of irrelevant information, examining priming effects in a lexical decision task immediately following WM recall. Results indicate the roles of both time and interference constraints in determining task performance. In particular, the role of time available seemed crucial at the highest WM loads (i.e., 3 and 4 memoranda). These were also associated with a higher activation of no-longer-relevant information but, in this case, independently from time available for processing. © 2015 The British Psychological Society.

Distinctiveness and encoding effects in online sentence comprehension

PubMed Central

Hofmeister, Philip; Vasishth, Shravan

2014-01-01

In explicit memory recall and recognition tasks, elaboration and contextual isolation both facilitate memory performance. Here, we investigate these effects in the context of sentence processing: targets for retrieval during online sentence processing of English object relative clause constructions differ in the amount of elaboration associated with the target noun phrase, or the homogeneity of superficial features (text color). Experiment 1 shows that greater elaboration for targets during the encoding phase reduces reading times at retrieval sites, but elaboration of non-targets has considerably weaker effects. Experiment 2 illustrates that processing isolated superficial features of target noun phrases—here, a green word in a sentence with words colored white—does not lead to enhanced memory performance, despite triggering longer encoding times. These results are interpreted in the light of the memory models of Nairne, 1990, 2001, 2006, which state that encoding remnants contribute to the set of retrieval cues that provide the basis for similarity-based interference effects. PMID:25566105

SSI/SSDI Outreach, Access, and Recovery (SOAR): Disability Application Outcomes Among Homeless Adults.

PubMed

Lowder, Evan M; Desmarais, Sarah L; Neupert, Shevaun D; Truelove, Melissa A

2017-11-01

The SSI/SSDI Outreach, Access, and Recovery (SOAR) program has been shown to increase access to Supplemental Security Income and Social Security Disability Insurance benefits among homeless adults. However, little empirical data exist on how or for whom SOAR achieves successful application outcomes. This study investigated applicant and application characteristics associated with disability application outcomes among homeless adults. Secondary data on 6,361 SOAR-assisted applications were obtained. Multilevel models investigated between-applicant differences in application processing time and decision as a function of applicant and application characteristics. Older age and living in an institution were associated with greater odds of application approval. Female gender and receipt of public assistance were associated with longer processing time and lower odds of approval. Except for quality review, SOAR critical components were associated with greater odds of approval. Women and adults receiving public assistance appear disadvantaged in the SOAR application process. SOAR critical components promote successful disability application outcomes.

Gone for 60 seconds: reactivation length determines motor memory degradation during reconsolidation.

PubMed

de Beukelaar, Toon T; Woolley, Daniel G; Wenderoth, Nicole

2014-10-01

When a stable memory is reactivated it becomes transiently labile and requires restabilization, a process known as reconsolidation. Animal studies have convincingly demonstrated that during reconsolidation memories are modifiable and can be erased when reactivation is followed by an interfering intervention. Few studies have been conducted in humans, however, and results are inconsistent regarding the extent to which a memory can be degraded. We used a motor sequence learning paradigm to show that the length of reactivation constitutes a crucial boundary condition determining whether human motor memories can be degraded. In our first experiment, we found that a short reactivation (less than 60 sec) renders the memory labile and susceptible to degradation through interference, while a longer reactivation does not. In our second experiment, we reproduce these results and show a significant linear relationship between the length of memory reactivation and the detrimental effect of the interfering task performed afterwards, i.e., the longer the reactivation, the smaller the memory loss due to interference. Our data suggest that reactivation via motor execution activates a time-dependent process that initially destabilizes the memory, which is then followed by restabilization during further practice.

Microbiological and abiotic processes in modelling longer-term marine corrosion of steel.

PubMed

Melchers, Robert E

2014-06-01

Longer term exposure of mild steel in natural (biotic) waters progresses as a bimodal function of time, both for corrosion mass loss and for pit depth. Recent test results, however, found this also for immersion in clean fresh, almost pure and triply distilled waters. This shows chlorides or microbiological activity is not essential for the electrochemical processes producing bimodal behaviour. It is proposed that the first mode is aerobic corrosion that eventually produces a non-homogeneous corroded surface and rust coverage sufficient to allow formation of anoxic niches. Within these, aggressive autocatalytic reduction then occurs under anoxic abiotic conditions, caused by sulfide species originating from the MnS inclusions typical in steels. This is consistent with Wranglen's model for abiotic anoxic crevice and pitting corrosion without external aggressive ions. In biotic conditions, metabolites from anaerobic bacterial activity within and near the anoxic niches provides additional (sulfide) species to contribute to the severity of corrosion. Limited observational evidence that supports this hypothesis is given but further investigation is required to determine all contributor(s) to the cathodic current for the electrochemical reaction. The results are important for estimating the contribution of microbiological corrosion in infrastructure applications. © 2013.

A Deficit in Older Adults' Effortful Selection of Cued Responses

PubMed Central

Proctor, Robert W.; Vu, Kim-Phuong L.; Pick, David F.

2007-01-01

J. J. Adam et al. (1998) provided evidence for an “age-related deficit in preparing 2 fingers on 2 hands, but not on 1 hand” (p. 870). Instead of having an anatomical basis, the deficit could result from the effortful processing required for individuals to select cued subsets of responses that do not coincide with left and right subgroups. The deficit also could involve either the ultimate benefit that can be attained or the time required to attain that benefit. The authors report 3 experiments (Ns = 40, 48, and 32 participants, respectively) in which they tested those distinctions by using an overlapped hand placement (participants alternated the index and middle fingers of the hands), a normal hand placement, and longer precuing intervals than were used in previous studies. The older adults were able to achieve the full precuing benefit shown by younger adults but required longer to achieve the maximal benefit for most pairs of responses. The deficit did not depend on whether the responses were from different hands, suggesting that it lies primarily in the effortful processing required for those subsets of cued responses that are not selected easily. PMID:16801319

Interventions to reduce discrimination and stigma: the state of the art.

PubMed

Gronholm, Petra C; Henderson, Claire; Deb, Tanya; Thornicroft, Graham

2017-03-01

There is a rich literature on the nature of mental health-related stigma and the processes by which it severely affects the life chances of people with mental health problems. However, applying this knowledge to deliver and evaluate interventions to reduce discrimination and stigma in a lasting way is a complex and long-term challenge. We conducted a narrative synthesis of systematic reviews published since 2012, and supplemented this with papers published subsequently as examples of more recent work. There is evidence for small to moderate positive impacts of both mass media campaigns and interventions for target groups in terms of stigma-related knowledge, attitudes, and intended behaviour in terms of desire for contact. However, the limited evidence from longer follow-up times suggests that it is not clear whether short-term contact interventions have a lasting impact. The risk that short-term interventions may only have a short-term impact suggests a need to study longer term interventions and to use interim process and outcome data to improve interventions along the way. There is scope for more thorough application of intergroup contact theory whenever contact is used and of evidence-based teaching and assessment methods when skills training is used for target groups.

Effect of low-level copper and pentachlorophenol exposure on various early life stages of Xenopus laevis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fort, D.J.; Stover, E.L.

1996-12-31

An evaluation of the effects of low-level copper and pentachlorophenol exposure on various early life stages of the South African clawed frog, Xenopus laevis, was performed using stage-specific and long-term continuous exposures. Stage-specific exposure experiments were conducted such that separate subsets of embryos and larvae from the same clutch were exposed to two toxicants, copper and pentachlorphenol, from 0 d to 4 d (standard Frog Embryo Teratogenesis Assay--Xenopus [FETAX]), 4 d to 8 d, 8 d to 12 d, and 12 d to 16 d. Results from two separate concentration-response experiments indicated that sensitivity to either toxicant increased in eachmore » successive time period. Longer-term exposure studies conducted for 60 to 75 days indicated that copper, but not pentachlorophenol induced reduction deficiency malformations of the hind limb at concentrations as low as 0.05 mg/L. Pentachlorophenol concentrations as low as 0.5 {micro}g/L inhibited tail resorption. However, copper did not adversely affect the process of tail resorption. These results indicated that studies evaluating longer-term developmental processes are important in ecological hazard evaluation.« less

Effect of edible coating on the aromatic attributes of roasted coffee beans.

PubMed

Rattan, Supriya; Parande, A K; Ramalakshmi, K; Nagaraju, V D

2015-09-01

Coffee is known throughout the world for its distinct aroma and flavour which results from a number of volatile compounds present in it. It is very difficult to arrest the aromatic compounds once the roasting process is complete and it becomes even more challenging to store the beans for a longer time with the retained volatiles as these compounds are easily lost during industrialized processing such as the grinding of roasted coffee beans and storage of ground coffee. Thus, an attempt was made to minimise the loss of volatile from roasted coffee beans by coating with Carboxymethyl cellulose (CMC), Hydroxypropylmethyl cellulose (HPMC) and Whey protein concentrate. Coffee volatiles were analysed by Gas chromatography and 14 major compounds were identified and compared in this study. Results showed an increase in the relative area of major volatile compounds in coated roasted coffee beans when compared with unroasted coffee beans for consecutive two months. Moreover, effect of coating on textural properties and non-volatiles were also analysed. The results have indicated that edible coatings preserve the sensory properties of roasted coffee beans for a longer shelf life and cellulose derivatives, as an edible coating, exhibited the best protecting effect on roasted coffee beans.

Connectivity variations in time and space: role of events, structures and morphology in ephemeral channels

NASA Astrophysics Data System (ADS)

Hooke, Janet

2017-04-01

Flow and sediment processes in ephemeral channels are highly dynamic and spatially variable. The connectivity characteristics in a range of events are examined for several semi-arid catchments in Southeast Spain. Rainfall thresholds for runoff generation on slopes and for flow generation in channels have been identified at various scales. In many events, flow is not continuous down the channel system due partly to localised rainfall and to transmission losses but also to structural and morphological conditions. One extreme flow event with high sediment supply produced very high flow and sediment connectivity throughout the system. Results of spatial analysis of variation in hydraulics and sediment processes are presented and the effects are analysed. Amounts and locations of sediment storage were identified from repeat surveys. The overall contribution of such an event to morphological and sedimentological changes in the channel and longer-term landscape evolution is assessed. Land use and management are demonstrated to have a profound influence on the sediment delivery and connectivity functioning. The implications for land, channel and flood management in such an environment, together with the impacts of longer-term variations in flow regime due to land use and climate change, are considered.

Probing the Time Scale of FPOP (Fast Photochemical Oxidation of Proteins): Radical Reactions Extend Over Tens of Milliseconds

NASA Astrophysics Data System (ADS)

Vahidi, Siavash; Konermann, Lars

2016-07-01

Hydroxyl radical (ṡOH) labeling with mass spectrometry detection reports on protein conformations and interactions. Fast photochemical oxidation of proteins (FPOP) involves ṡOH production via H2O2 photolysis by UV laser pulses inside a flow tube. The experiments are conducted in the presence of a scavenger (usually glutamine) that shortens the ṡOH lifetime. The literature claims that FPOP takes place within 1 μs. This ultrafast time scale implies that FPOP should be immune to labeling-induced artifacts that may be encountered with other techniques. Surprisingly, the FPOP time scale has never been validated in direct kinetic measurements. Here we employ flash photolysis for probing oxidation processes under typical FPOP conditions. Bleaching of the reporter dye cyanine-5 (Cy5) served as readout of the time-dependent radical milieu. Surprisingly, Cy5 oxidation extends over tens of milliseconds. This time range is four orders of magnitude longer than expected from the FPOP literature. We demonstrate that the glutamine scavenger generates metastable secondary radicals in the FPOP solution, and that these radicals lengthen the time frame of Cy5 oxidation. Cy5 and similar dyes are widely used for monitoring the radical dose experienced by proteins in solution. The measured Cy5 kinetics thus strongly suggest that protein oxidation in FPOP extends over a much longer time window than previously thought (i.e., many milliseconds instead of one microsecond). The optical approach developed here should be suitable for assessing the performance of future FPOP-like techniques with improved temporal labeling characteristics.

Human Life History Evolution Explains Dissociation between the Timing of Tooth Eruption and Peak Rates of Root Growth

PubMed Central

Dean, M. Christopher; Cole, Tim J.

2013-01-01

We explored the relationship between growth in tooth root length and the modern human extended period of childhood. Tooth roots provide support to counter chewing forces and so it is advantageous to grow roots quickly to allow teeth to erupt into function as early as possible. Growth in tooth root length occurs with a characteristic spurt or peak in rate sometime between tooth crown completion and root apex closure. Here we show that in Pan troglodytes the peak in root growth rate coincides with the period of time teeth are erupting into function. However, the timing of peak root velocity in modern humans occurs earlier than expected and coincides better with estimates for tooth eruption times in Homo erectus. With more time to grow longer roots prior to eruption and smaller teeth that now require less support at the time they come into function, the root growth spurt no longer confers any advantage in modern humans. We suggest that a prolonged life history schedule eventually neutralised this adaptation some time after the appearance of Homo erectus. The root spurt persists in modern humans as an intrinsic marker event that shows selection operated, not primarily on tooth tissue growth, but on the process of tooth eruption. This demonstrates the overarching influence of life history evolution on several aspects of dental development. These new insights into tooth root growth now provide an additional line of enquiry that may contribute to future studies of more recent life history and dietary adaptations within the genus Homo. PMID:23342167

Motor programming in apraxia of speech.

PubMed

Maas, Edwin; Robin, Donald A; Wright, David L; Ballard, Kirrie J

2008-08-01

Apraxia of Speech (AOS) is an impairment of motor programming. However, the exact nature of this deficit remains unclear. The present study examined motor programming in AOS in the context of a recent two-stage model [Klapp, S. T. (1995). Motor response programming during simple and choice reaction time: The role of practice. Journal of Experimental Psychology: Human Perception and Performance, 21, 1015-1027; Klapp, S. T. (2003). Reaction time analysis of two types of motor preparation for speech articulation: Action as a sequence of chunks. Journal of Motor Behavior, 35, 135-150] that proposes a preprogramming stage (INT) and a process that assigns serial order to multiple programs in a sequence (SEQ). The main hypothesis was that AOS involves a process-specific deficit in the INT (preprogramming) stage of processing, rather than in the on-line serial ordering (SEQ) and initiation of movement. In addition, we tested the hypothesis that AOS involves a central (i.e., modality-general) motor programming deficit. We used a reaction time paradigm that provides two dependent measures: study time (the amount of time for participants to ready a motor response; INT), and reaction time (time to initiate movement; SEQ). Two experiments were conducted to examine INT and SEQ in AOS: Experiment 1 involved finger movements, Experiment 2 involved speech movements analogous to the finger movements. Results showed longer preprogramming time for patients with AOS but normal sequencing and initiation times, relative to controls. Together, the findings are consistent with the hypothesis of a process-specific, but central (modality-independent) deficit in AOS; alternative explanations are also discussed.

Modeling information diffusion in time-varying community networks

NASA Astrophysics Data System (ADS)

Cui, Xuelian; Zhao, Narisa

2017-12-01

Social networks are rarely static, and they typically have time-varying network topologies. A great number of studies have modeled temporal networks and explored social contagion processes within these models; however, few of these studies have considered community structure variations. In this paper, we present a study of how the time-varying property of a modular structure influences the information dissemination. First, we propose a continuous-time Markov model of information diffusion where two parameters, mobility rate and community attractiveness, are introduced to address the time-varying nature of the community structure. The basic reproduction number is derived, and the accuracy of this model is evaluated by comparing the simulation and theoretical results. Furthermore, numerical results illustrate that generally both the mobility rate and community attractiveness significantly promote the information diffusion process, especially in the initial outbreak stage. Moreover, the strength of this promotion effect is much stronger when the modularity is higher. Counterintuitively, it is found that when all communities have the same attractiveness, social mobility no longer accelerates the diffusion process. In addition, we show that the local spreading in the advantage group has been greatly enhanced due to the agglomeration effect caused by the social mobility and community attractiveness difference, which thus increases the global spreading.

Variability in organic carbon reactivity across lake residence time and trophic gradients

NASA Astrophysics Data System (ADS)

Evans, Chris D.; Futter, Martyn N.; Moldan, Filip; Valinia, Salar; Frogbrook, Zoe; Kothawala, Dolly N.

2017-11-01

The transport of dissolved organic carbon from land to ocean is a large dynamic component of the global carbon cycle. Inland waters are hotspots for organic matter turnover, via both biological and photochemical processes, and mediate carbon transfer between land, oceans and atmosphere. However, predicting dissolved organic carbon reactivity remains problematic. Here we present in situ dissolved organic carbon budget data from 82 predominantly European and North American water bodies with varying nutrient concentrations and water residence times ranging from one week to 700 years. We find that trophic status strongly regulates whether water bodies act as net dissolved organic carbon sources or sinks, and that rates of both dissolved organic carbon production and consumption can be predicted from water residence time. Our results suggest a dominant role of rapid light-driven removal in water bodies with a short water residence time, whereas in water bodies with longer residence times, slower biotic production and consumption processes are dominant and counterbalance one another. Eutrophication caused lakes to transition from sinks to sources of dissolved organic carbon. We conclude that rates and locations of dissolved organic carbon processing and associated CO2 emissions in inland waters may be misrepresented in global carbon budgets if temporal and spatial reactivity gradients are not accounted for.

Identifying differences in biased affective information processing in major depression.

PubMed

Gollan, Jackie K; Pane, Heather T; McCloskey, Michael S; Coccaro, Emil F

2008-05-30

This study investigates the extent to which participants with major depression differ from healthy comparison participants in the irregularities in affective information processing, characterized by deficits in facial expression recognition, intensity categorization, and reaction time to identifying emotionally salient and neutral information. Data on diagnoses, symptom severity, and affective information processing using a facial recognition task were collected from 66 participants, male and female between ages 18 and 54 years, grouped by major depressive disorder (N=37) or healthy non-psychiatric (N=29) status. Findings from MANCOVAs revealed that major depression was associated with a significantly longer reaction time to sad facial expressions compared with healthy status. Also, depressed participants demonstrated a negative bias towards interpreting neutral facial expressions as sad significantly more often than healthy participants. In turn, healthy participants interpreted neutral faces as happy significantly more often than depressed participants. No group differences were observed for facial expression recognition and intensity categorization. The observed effects suggest that depression has significant effects on the perception of the intensity of negative affective stimuli, delayed speed of processing sad affective information, and biases towards interpreting neutral faces as sad.

Distinct constrictive processes, separated in time and space, divide caulobacter inner and outer membranes.

PubMed

Judd, Ellen M; Comolli, Luis R; Chen, Joseph C; Downing, Kenneth H; Moerner, W E; McAdams, Harley H

2005-10-01

Cryoelectron microscope tomography (cryoEM) and a fluorescence loss in photobleaching (FLIP) assay were used to characterize progression of the terminal stages of Caulobacter crescentus cell division. Tomographic cryoEM images of the cell division site show separate constrictive processes closing first the inner membrane (IM) and then the outer membrane (OM) in a manner distinctly different from that of septum-forming bacteria. FLIP experiments had previously shown cytoplasmic compartmentalization (when cytoplasmic proteins can no longer diffuse between the two nascent progeny cell compartments) occurring 18 min before daughter cell separation in a 135-min cell cycle so the two constrictive processes are separated in both time and space. In the very latest stages of both IM and OM constriction, short membrane tether structures are observed. The smallest observed pre-fission tethers were 60 nm in diameter for both the inner and outer membranes. Here, we also used FLIP experiments to show that both membrane-bound and periplasmic fluorescent proteins diffuse freely through the FtsZ ring during most of the constriction procession.

Speech timing and working memory in profoundly deaf children after cochlear implantation

PubMed Central

Burkholder, Rose A.; Pisoni, David B.

2012-01-01

Thirty-seven profoundly deaf children between 8- and 9-years-old with cochlear implants and a comparison group of normal-hearing children were studied to measure speaking rates, digit spans, and speech timing during digit span recall. The deaf children displayed longer sentence durations and pauses during recall and shorter digit spans compared to the normal-hearing children. Articulation rates, measured from sentence durations, were strongly correlated with immediate memory span in both normal-hearing and deaf children, indicating that both slower subvocal rehearsal and scanning processes may be factors that contribute to the deaf children’s shorter digit spans. These findings demonstrate that subvocal verbal rehearsal speed and memory scanning processes are not only dependent on chronological age as suggested in earlier research by Cowan and colleagues (1998). Instead, in this clinical population the absence of early auditory experience and phonological processing activities before implantation appears to produce measurable effects on the working memory processes that rely on verbal rehearsal and serial scanning of phonological information in short-term memory. PMID:12742763

Second order nonlinear QED processes in ultra-strong laser fields

NASA Astrophysics Data System (ADS)

Mackenroth, Felix

2017-10-01

In the interaction of ultra-intense laser fields with matter the ever increasing peak laser intensities render nonlinear QED effects ever more important. For long, ultra-intense laser pulses scattering large systems, like a macroscopic plasma, the interaction time can be longer than the scattering time, leading to multiple scatterings. These are usually approximated as incoherent cascades of single-vertex processes. Under certain conditions, however, this common cascade approximation may be insufficient, as it disregards several effects such as coherent processes, quantum interferences or pulse shape effects. Quantifying deviations of the full amplitude of multiple scatterings from the commonly employed cascade approximations is a formidable, yet unaccomplished task. In this talk we are going to discuss how to compute second order nonlinear QED amplitudes and relate them to the conventional cascade approximation. We present examples for typical second order processes and benchmark the full result against common approximations. We demonstrate that the approximation of multiple nonlinear QED scatterings as a cascade of single interactions has certain limitations and discuss these limits in light of upcoming experimental tests.

Eye Movements in Strategic Choice

PubMed Central

Gächter, Simon; Noguchi, Takao; Mullett, Timothy L.

2015-01-01

Abstract In risky and other multiattribute choices, the process of choosing is well described by random walk or drift diffusion models in which evidence is accumulated over time to threshold. In strategic choices, level‐k and cognitive hierarchy models have been offered as accounts of the choice process, in which people simulate the choice processes of their opponents or partners. We recorded the eye movements in 2 × 2 symmetric games including dominance‐solvable games like prisoner's dilemma and asymmetric coordination games like stag hunt and hawk–dove. The evidence was most consistent with the accumulation of payoff differences over time: we found longer duration choices with more fixations when payoffs differences were more finely balanced, an emerging bias to gaze more at the payoffs for the action ultimately chosen, and that a simple count of transitions between payoffs—whether or not the comparison is strategically informative—was strongly associated with the final choice. The accumulator models do account for these strategic choice process measures, but the level‐k and cognitive hierarchy models do not. © 2015 The Authors. Journal of Behavioral Decision Making published by John Wiley & Sons Ltd. PMID:27513881

Innovation Chinese rice wine brewing technology by bi-acidification to exclude rice soaking process.

PubMed

Wei, Xiao Lu; Liu, Shuang Ping; Yu, Jian Shen; Yu, Yong Jian; Zhu, Sheng Hu; Zhou, Zhi Lei; Hu, Jian; Mao, Jian

2017-04-01

As a traditional fermented alcoholic beverage of China, Chinese rice wine (CRW) had a long history of more than 5000 years. Rice soaking process was the most crucial step during CRW brewing process, because rice soaking quality directly determined the quality of CRW. However, rice soaking water would cause the eutrophication of water bodies and waste of water. The longer time of rice soaking, the higher the content of biogenic amine, and it would have a huge impact on human health. An innovation brewing technology was carried out to exclude the rice soaking process and the Lactobacillus was added to make up for the total acid. Compared to the traditional brewing technology, the new technology saved water resources and reduced environmental pollution. The concentration of biogenic amine was also decreased by 27.16%, which improving the security of the CRW. The esters increased led to more soft-tasted CRW and less aging time; the quality of CRW would be improved with less alcohol. Copyright © 2016 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.

Dielectric behavior of MgO:Li/sup +/ crystals

DOE Office of Scientific and Technical Information (OSTI.GOV)

Puma, M.; Lorincz, A.; Andrews, J.F.

1980-01-01

Measurements of the dielectric constant in crystals of MgO doped with Li/sup +/ ions have been carried out after quenching from anneals at 1300/sup 0/C in static air. Prior to heat treatment the crystals showed no discernible dielectric loss but afterwards the loss tangent exceeded 0.4. For 10 min anneals the dielectric relaxation is very close to a Debye process and the temperature dependence of the maximum of the loss peak corresponds to an activation energy of 0.72 eV. When plotted in the form of a Cole-Cole arc the data indicate that deviation from a Debye relaxation amounts to amore » distribution of relaxation time no greater than that which can be accounted for with a distribution of activation energies only 0.007 eV. For longer heating times overlapping relaxation processes appear. The lack of broadening of the loss peak and the magnitude of the relaxation time yield clues as to possible loss mechanisms.« less

Dielectric behavior of MgO:Li/sup +/ crystals

DOE Office of Scientific and Technical Information (OSTI.GOV)

Puma, M.; Lorincz, A.; Andrews, J.F.

1982-06-01

Measurements of the dielectric constant in crystals of MgO doped with Li/sup +/ ions have been carried out after quenching from anneals at 1300 /sup 0/C in static air. Prior to heat treatment, the crystals showed no discernible dielectric loss, but afterwards, the loss tangent exceeded 0.4. For 10-min anneals, the dielectric relaxation is very close to a Debye process, and the temperature dependence of the maximum of the loss peak corresponds to an activation energy of 0.724 eV. When plotted in the form of a Cole-Cole arc, the data indicate that deviation from a Debye relaxation amounts to amore » distribution of relaxation time no greater than that which can be accounted for with a distribution of activation energies of only 0.007 eV. For longer heating times, overlapping relaxation processes appear. The lack of broadening of the loss peak, and the magnitude of the relaxation time, yield clues as to possible loss mechanisms.« less

Effects of operational conditions on sludge degradation and organic acids formation in low-critical wet air oxidation.

PubMed

Chung, Jinwook; Lee, Mikyung; Ahn, Jaehwan; Bae, Wookeun; Lee, Yong-Woo; Shim, Hojae

2009-02-15

Wet air oxidation processes are to treat highly concentrated organic compounds including refractory materials, sludge, and night soil, and usually operated at supercritical water conditions of high temperature and pressure. In this study, the effects of operational conditions including temperature, pressure, and oxidant dose on sludge degradation and conversion into subsequent intermediates such as organic acids were investigated at low critical wet oxidation conditions. The reaction time and temperature in the wet air oxidation process was shown an important factor affecting the liquefaction of volatile solids, with more significant effect on the thermal hydrolysis reaction rather than the oxidation reaction. The degradation efficiency of sludge and the formation of organic acids were improved with longer reaction time and higher reaction temperature. For the sludge reduction and the organic acids formation under the wet air oxidation, the optimal conditions for reaction temperature, time, pressure, and oxidant dose were shown approximately 240 degrees C, 30min, 60atm, and 2.0L/min, respectively.

Experimental and theoretical investigation of radiation and dynamics properties in laser-produced carbon plasmas

NASA Astrophysics Data System (ADS)

Min, Qi; Su, Maogen; Wang, Bo; Cao, Shiquan; Sun, Duixiong; Dong, Chenzhong

2018-05-01

The radiation and dynamics properties of laser-produced carbon plasma in vacuum were studied experimentally with aid of a spatio-temporally resolved emission spectroscopy technique. In addition, a radiation hydrodynamics model based on the fluid dynamic equations and the radiative transfer equation was presented, and calculation of the charge states was performed within the time-dependent collisional radiative model. Detailed temporal and spatial evolution behavior about plasma parameters have been analyzed, such as velocity, electron temperature, charge state distribution, energy level population, and various atomic processes. At the same time, the effects of different atomic processes on the charge state distribution were examined. Finally, the validity of assuming a local thermodynamic equilibrium in the carbon plasma expansion was checked, and the results clearly indicate that the assumption was valid only at the initial (<80 ns) stage of plasma expansion. At longer delay times, it was not applicable near the plasma boundary because of a sharp drop of plasma temperature and electron density.

Dopant effects on 2-ethyl-1-hexanol: A dual-channel impedance spectroscopy and neutron scattering study

DOE Office of Scientific and Technical Information (OSTI.GOV)

Singh, Lokendra P.; Richert, Ranko, E-mail: ranko@asu.edu; Raihane, Ahmed

2015-01-07

A two-channel impedance technique has been used to study the relaxation behavior of 2-ethyl-1-hexanol with polar and non-polar dopants at the few percent concentration level over a wide temperature and frequency range. The non-polar dopants shift both the Debye and the primary structural relaxation time in the same direction, to shorter times for 3-methylpentane and to longer times for squalane, consistent with the relative glass transition temperatures (T{sub g}) of the components. By contrast, polar dopants such as water or methanol modify the α-process towards slower dynamics and increased amplitude, while the Debye process is accelerated and with a decreasedmore » amplitude. This effect of adding water to alcohol is explained by water promoting more compact structures with reduced Kirkwood correlation factors. This picture is consistent with a shift in the neutron scattering pre-peak to lower scattering vectors and with simulation work on alcohol-water systems.« less

Cross-scale impact of climate temporal variability on ecosystem water and carbon fluxes

DOE PAGES

Paschalis, Athanasios; Fatichi, Simone; Katul, Gabriel G.; ...

2015-08-07

While the importance of ecosystem functioning is undisputed in the context of climate change and Earth system modeling, the role of short-scale temporal variability of hydrometeorological forcing (~1 h) on the related ecosystem processes remains to be fully understood. Additionally, various impacts of meteorological forcing variability on water and carbon fluxes across a range of scales are explored here using numerical simulations. Synthetic meteorological drivers that highlight dynamic features of the short temporal scale in series of precipitation, temperature, and radiation are constructed. These drivers force a mechanistic ecohydrological model that propagates information content into the dynamics of water andmore » carbon fluxes for an ensemble of representative ecosystems. The focus of the analysis is on a cross-scale effect of the short-scale forcing variability on the modeled evapotranspiration and ecosystem carbon assimilation. Interannual variability of water and carbon fluxes is emphasized in the analysis. The main study inferences are summarized as follows: (a) short-scale variability of meteorological input does affect water and carbon fluxes across a wide range of time scales, spanning from the hourly to the annual and longer scales; (b) different ecosystems respond to the various characteristics of the short-scale variability of the climate forcing in various ways, depending on dominant factors limiting system productivity; (c) whenever short-scale variability of meteorological forcing influences primarily fast processes such as photosynthesis, its impact on the slow-scale variability of water and carbon fluxes is small; and (d) whenever short-scale variability of the meteorological forcing impacts slow processes such as movement and storage of water in the soil, the effects of the variability can propagate to annual and longer time scales.« less

Cross-scale impact of climate temporal variability on ecosystem water and carbon fluxes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Paschalis, Athanasios; Fatichi, Simone; Katul, Gabriel G.

While the importance of ecosystem functioning is undisputed in the context of climate change and Earth system modeling, the role of short-scale temporal variability of hydrometeorological forcing (~1 h) on the related ecosystem processes remains to be fully understood. Additionally, various impacts of meteorological forcing variability on water and carbon fluxes across a range of scales are explored here using numerical simulations. Synthetic meteorological drivers that highlight dynamic features of the short temporal scale in series of precipitation, temperature, and radiation are constructed. These drivers force a mechanistic ecohydrological model that propagates information content into the dynamics of water andmore » carbon fluxes for an ensemble of representative ecosystems. The focus of the analysis is on a cross-scale effect of the short-scale forcing variability on the modeled evapotranspiration and ecosystem carbon assimilation. Interannual variability of water and carbon fluxes is emphasized in the analysis. The main study inferences are summarized as follows: (a) short-scale variability of meteorological input does affect water and carbon fluxes across a wide range of time scales, spanning from the hourly to the annual and longer scales; (b) different ecosystems respond to the various characteristics of the short-scale variability of the climate forcing in various ways, depending on dominant factors limiting system productivity; (c) whenever short-scale variability of meteorological forcing influences primarily fast processes such as photosynthesis, its impact on the slow-scale variability of water and carbon fluxes is small; and (d) whenever short-scale variability of the meteorological forcing impacts slow processes such as movement and storage of water in the soil, the effects of the variability can propagate to annual and longer time scales.« less

Discrimination of human and dog faces and inversion responses in domestic dogs (Canis familiaris).

PubMed

Racca, Anaïs; Amadei, Eleonora; Ligout, Séverine; Guo, Kun; Meints, Kerstin; Mills, Daniel

2010-05-01

Although domestic dogs can respond to many facial cues displayed by other dogs and humans, it remains unclear whether they can differentiate individual dogs or humans based on facial cues alone and, if so, whether they would demonstrate the face inversion effect, a behavioural hallmark commonly used in primates to differentiate face processing from object processing. In this study, we first established the applicability of the visual paired comparison (VPC or preferential looking) procedure for dogs using a simple object discrimination task with 2D pictures. The animals demonstrated a clear looking preference for novel objects when simultaneously presented with prior-exposed familiar objects. We then adopted this VPC procedure to assess their face discrimination and inversion responses. Dogs showed a deviation from random behaviour, indicating discrimination capability when inspecting upright dog faces, human faces and object images; but the pattern of viewing preference was dependent upon image category. They directed longer viewing time at novel (vs. familiar) human faces and objects, but not at dog faces, instead, a longer viewing time at familiar (vs. novel) dog faces was observed. No significant looking preference was detected for inverted images regardless of image category. Our results indicate that domestic dogs can use facial cues alone to differentiate individual dogs and humans and that they exhibit a non-specific inversion response. In addition, the discrimination response by dogs of human and dog faces appears to differ with the type of face involved.

Thermal erosion of a permafrost coastline: Improving process-based models using time-lapse photography

USGS Publications Warehouse

Wobus, C.; Anderson, R.; Overeem, I.; Matell, N.; Clow, G.; Urban, F.

2011-01-01

Coastal erosion rates locally exceeding 30 m y-1 have been documented along Alaska's Beaufort Sea coastline, and a number of studies suggest that these erosion rates have accelerated as a result of climate change. However, a lack of direct observational evidence has limited our progress in quantifying the specific processes that connect climate change to coastal erosion rates in the Arctic. In particular, while longer ice-free periods are likely to lead to both warmer surface waters and longer fetch, the relative roles of thermal and mechanical (wave) erosion in driving coastal retreat have not been comprehensively quantified. We focus on a permafrost coastline in the northern National Petroleum Reserve-Alaska (NPR-A), where coastal erosion rates have averaged 10-15 m y-1 over two years of direct monitoring. We take advantage of these extraordinary rates of coastal erosion to observe and quantify coastal erosion directly via time-lapse photography in combination with meteorological observations. Our observations indicate that the erosion of these bluffs is largely thermally driven, but that surface winds play a crucial role in exposing the frozen bluffs to the radiatively warmed seawater that drives melting of interstitial ice. To first order, erosion in this setting can be modeled using formulations developed to describe iceberg deterioration in the open ocean. These simple models provide a conceptual framework for evaluating how climate-induced changes in thermal and wave energy might influence future erosion rates in this setting.

Adolescents' technology and face-to-face time use predict objective sleep outcomes.

PubMed

Tavernier, Royette; Heissel, Jennifer A; Sladek, Michael R; Grant, Kathryn E; Adam, Emma K

2017-08-01

The present study examined both within- and between-person associations between adolescents' time use (technology-based activities and face-to-face interactions with friends and family) and sleep behaviors. We also assessed whether age moderated associations between adolescents' time use with friends and family and sleep. Adolescents wore an actigraph monitor and completed brief evening surveys daily for 3 consecutive days. Adolescents (N=71; mean age=14.50 years old, SD=1.84; 43.7% female) were recruited from 3 public high schools in the Midwest. We assessed 8 technology-based activities (eg, texting, working on a computer), as well as time spent engaged in face-to-face interactions with friends and family, via questions on adolescents' evening surveys. Actigraph monitors assessed 3 sleep behaviors: sleep latency, sleep hours, and sleep efficiency. Hierarchical linear models indicated that texting and working on the computer were associated with shorter sleep, whereas time spent talking on the phone predicted longer sleep. Time spent with friends predicted shorter sleep latencies, while family time predicted longer sleep latencies. Age moderated the association between time spent with friends and sleep efficiency, as well as between family time and sleep efficiency. Specifically, longer time spent interacting with friends was associated with higher sleep efficiency but only among younger adolescents. Furthermore, longer family time was associated with higher sleep efficiency but only for older adolescents. Findings are discussed in terms of the importance of regulating adolescents' technology use and improving opportunities for face-to-face interactions with friends, particularly for younger adolescents. Copyright © 2017 National Sleep Foundation. Published by Elsevier Inc. All rights reserved.

Charging and Discharging Processes of Thermal Energy Storage System Using Phase change materials

NASA Astrophysics Data System (ADS)

Kanimozhi, B., Dr.; Harish, Kasilanka; Sai Tarun, Bellamkonda; Saty Sainath Reddy, Pogaku; Sai Sujeeth, Padakandla

2017-05-01

The objective of the study is to investigate the thermal characteristics of charging and discharge processes of fabricated thermal energy storage system using Phase change materials. Experiments were performed with phase change materials in which a storage tank have designed and developed to enhance the heat transfer rate from the solar tank to the PCM storage tank. The enhancement of heat transfer can be done by using a number of copper tubes in the fabricated storage tank. This storage tank can hold or conserve heat energy for a much longer time than the conventional water storage system. Performance evaluations of experimental results during charging and discharging processes of paraffin wax have discussed. In which heat absorption and heat rejection have been calculated with various flow rate.

The Improvement Cycle: Analyzing Our Experience

NASA Technical Reports Server (NTRS)

Pajerski, Rose; Waligora, Sharon

1996-01-01

NASA's Software Engineering Laboratory (SEL), one of the earliest pioneers in the areas of software process improvement and measurement, has had a significant impact on the software business at NASA Goddard. At the heart of the SEL's improvement program is a belief that software products can be improved by optimizing the software engineering process used to develop them and a long-term improvement strategy that facilitates small incremental improvements that accumulate into significant gains. As a result of its efforts, the SEL has incrementally reduced development costs by 60%, decreased error rates by 85%, and reduced cycle time by 25%. In this paper, we analyze the SEL's experiences on three major improvement initiatives to better understand the cyclic nature of the improvement process and to understand why some improvements take much longer than others.

Tackifier for addition polyimides

NASA Technical Reports Server (NTRS)

Butler, J. M.; St.clair, T. L.

1980-01-01

A modification to the addition polyimide, LaRC-160, was prepared to improve tack and drape and increase prepeg out-time. The essentially solventless, high viscosity laminating resin is synthesized from low cost liquid monomers. The modified version takes advantage of a reactive, liquid plasticizer which is used in place of solvent and helps solve a major problem of maintaining good prepeg tack and drape, or the ability of the prepeg to adhere to adjacent plies and conform to a desired shape during the lay up process. This alternate solventless approach allows both longer life of the polymer prepeg and the processing of low void laminates. This approach appears to be applicable to all addition polyimide systems.

Preparing for a decision support system.

PubMed

Callan, K

2000-08-01

The increasing pressure to reduce costs and improve outcomes is driving the health care industry to view information as a competitive advantage. Timely information is required to help reduce inefficiencies and improve patient care. Numerous disparate operational or transactional information systems with inconsistent and often conflicting data are no longer adequate to meet the information needs of integrated care delivery systems and networks in competitive managed care environments. This article reviews decision support system characteristics and describes a process to assess the preparedness of an organization to implement and use decision support systems to achieve a more effective, information-based decision process. Decision support tools included in this article range from reports to data mining.

Comparative bonding ability to dentin of a universal adhesive system and monomer conversion as functions of extended light curing times and storage.

PubMed

Sampaio, Paula Costa Pinheiro; Kruly, Paula de Castro; Ribeiro, Clara Cabral; Hilgert, Leandro Augusto; Pereira, Patrícia Nóbrega Rodrigues; Scaffa, Polliana Mendes Candia; Di Hipólito, Vinicius; D'Alpino, Paulo Henrique Perlatti; Garcia, Fernanda Cristina Pimentel

2017-11-01

The purpose of this in vitro study was to evaluate the bonding ability and monomer conversion of a universal adhesive system applied to dentin as functions of different curing times and storage. The results were compared among a variety of commercial adhesives. Flat superficial dentin surfaces were exposed on human molars and assigned into one of the following adhesives (n = 15): total-etch Adper Single Bond 2 (SB) and Optibond Solo Plus (OS), self-etch Optibond All in One (OA) and Clearfil SE Bond (CSE), and Scotchbond Universal Adhesive in self-etch mode (SU). The adhesives were applied following the manufacturers' instructions and cured for 10, 20, or 40s. Specimens were processed for the microtensile bond strength (µTBS) test in accordance with the non-trimming technique and tested after 24h and 2 years. The fractured specimens were classified under scanning electron microscopy (SEM). Infrared (IR) spectra were obtained and monomer conversion (%) was calculated by comparing the aliphatic-to-aromatic IR absorption peak ratio before and after polymerization (n=5). Data were analyzed by 2-way ANOVA/Tukey's tests (α = 0.05). At 24-h evaluation, OA and CSE presented similar bond strength means irrespective of the curing time, whereas SB and SU exhibited significantly higher means when cured for 40s as did OS when cured for 20 or 40s (p < 0.05). At 2-year evaluation, only OA exhibited significantly higher bond strength when cured for 20 and 40s (p < 0.05). When the evaluation times were compared, OA also exhibited the same bonding ability when cured for longer periods of time (20 and 40s). All of the adhesives tested exhibited significantly lower monomer conversion when photoactivated according to the manufacturers' instructions (10s). Higher monomer conversions obtained with longer light exposure allow only higher immediate bond strength for most of the adhesives tested. After 2-year storage, only the self-etching adhesive Optibond All-In-One exhibited the same bonding ability when cured for longer periods of time. Copyright © 2017 Elsevier Ltd. All rights reserved.

Optimization of the Ethanol Recycling Reflux Extraction Process for Saponins Using a Design Space Approach

PubMed Central

Gong, Xingchu; Zhang, Ying; Pan, Jianyang; Qu, Haibin

2014-01-01

A solvent recycling reflux extraction process for Panax notoginseng was optimized using a design space approach to improve the batch-to-batch consistency of the extract. Saponin yields, total saponin purity, and pigment yield were defined as the process critical quality attributes (CQAs). Ethanol content, extraction time, and the ratio of the recycling ethanol flow rate and initial solvent volume in the extraction tank (RES) were identified as the critical process parameters (CPPs) via quantitative risk assessment. Box-Behnken design experiments were performed. Quadratic models between CPPs and process CQAs were developed, with determination coefficients higher than 0.88. As the ethanol concentration decreases, saponin yields first increase and then decrease. A longer extraction time leads to higher yields of the ginsenosides Rb1 and Rd. The total saponin purity increases as the ethanol concentration increases. The pigment yield increases as the ethanol concentration decreases or extraction time increases. The design space was calculated using a Monte-Carlo simulation method with an acceptable probability of 0.90. Normal operation ranges to attain process CQA criteria with a probability of more than 0.914 are recommended as follows: ethanol content of 79–82%, extraction time of 6.1–7.1 h, and RES of 0.039–0.040 min−1. Most of the results of the verification experiments agreed well with the predictions. The verification experiment results showed that the selection of proper operating ethanol content, extraction time, and RES within the design space can ensure that the CQA criteria are met. PMID:25470598

Poloxamer 188 decreases susceptibility of artificial lipid membranes to electroporation.

PubMed Central

Sharma, V; Stebe, K; Murphy, J C; Tung, L

1996-01-01

The effect of a nontoxic, nonionic block co-polymeric surface active agent, poloxamer 188, on electroporation of artificial lipid membranes made of azolectin, was investigated. Two different experimental protocols were used in our study: charge pulse and voltage clamp. For the charge pulse protocol, membranes were pulsed with a 10-micronsecond rectangular voltage waveform, after which membrane voltage decay was observed through an external 1-M omega resistance. For the voltage clamp protocol the membranes were pulsed with a waveform that consisted of an initial 10-microsecond rectangular phase, followed by a negative sloped ramp that decayed to zero in the subsequent 500 microseconds. Several parameters characterizing the electroporation process were measured and compared for the control membranes and membranes treated with 1.0 mM poloxamer 188. For both the charge pulse and voltage clamp experiments, the threshold voltage (amplitude of initial rectangular phase) and latency time (time elapsed between the end of rectangular phase and the onset of membrane electroporation) were measured. Membrane conductance (measured 200 microseconds after the initial rectangular phase) and rise time (tr; the time required for the porated membrane to reach a certain conductance value) were also determined for the voltage clamp experiments, and postelectroporation time constant (PE tau; the time constant for transmembrane voltage decay after onset of electroporation) for the charge pulse experiments. The charge pulse experiments were performed on 23 membranes with 10 control and 13 poloxamer-treated membranes, and voltage pulse experiments on 49 membranes with 26 control and 23 poloxamer-treated membranes. For both charge pulse and voltage clamp experiments, poloxamer 188-treated membranes exhibited a statistically higher threshold voltage (p = 0.1 and p = 0.06, respectively), and longer latency time (p = 0.04 and p = 0.05, respectively). Also, poloxamer 188-treated membranes were found to have a relatively lower conductance (p = 0.001), longer time required for the porated membrane to reach a certain conductance value (p = 0.05), and longer postelectroporation time constant (p = 0.005). Furthermore, addition of poloxamer 188 was found to reduce the membrane capacitance by approximately 4-8% in 5 min. These findings suggest that poloxamer 188 adsorbs into the lipid bilayers, thereby decreasing their susceptibility to electroporation. Images FIGURE 1 PMID:8968593

Supercrystallization of KCl from solution irradiated by soft X-rays

NASA Astrophysics Data System (ADS)

Janavičius, A. J.; Rinkūnas, R.; Purlys, R.

2016-10-01

The X-rays influence on KCl crystallization in a saturated water solution has been investigated for the aim of comparing it with previously considered NaCl crystallization. The rate of crystallization has been measured in the drying drop in the solution activated by the irradiation. We have measured the influence of the irradiation time of the solution on the rates of KCl crystallization as well as the beginning of the crystallization processes on drying drops. For a longer irradiation time of the solution early crystallization in the drops occurs. A saturated water solution of KCl was irradiated with the diffractometer DRON-3M (Russian device) and this had a great influence on the two-step processes of crystallization. The ionization of the solution by soft X-rays can produce ions, metastable radicals in water, excited crystals' seeds and vacancies in growing crystals by Auger's effect. The X-rays generate a very fast crystallization in the drying drop.

MS-Electronic Nose Performance Improvement Using GC Retention Times And 2-Way And 3-Way Data Processing Methods

DOE Office of Scientific and Technical Information (OSTI.GOV)

Burian, Cosmin; Llobet, Eduard; Vilanova, Xavier

We have designed a challenging experimental sample set in the form of 20 solutions with a high degree of similarity in order to study whether the addition of chromatographic separation information improves the performance of regular MS based electronic noses. In order to make an initial study of the approach, two different chromatographic methods were used. By processing the data of these experiments with 2 and 3-way algorithms, we have shown that the addition of chromatographic separation information improves the results compared to the 2-way analysis of mass spectra or total ion chromatogram treated separately. Our findings show that whenmore » the chromatographic peaks are resolved (longer measurement times), 2-way methods work better than 3-way methods, whereas in the case of a more challenging measurement (more coeluted chromatograms, much faster GC-MS measurements) 3-way methods work better.« less

Drug procurement, the Global Fund and misguided competition policies

PubMed Central

2009-01-01

In an effort to increase competition and decrease price, the Global Fund to Fight AIDS, Tuberculosis and Malaria recently began asking some grant recipients to use international competitive bidding processes for certain drug purchases. Unfortunately, for countries like Kenya, this request has caused more harm than good. After awarding the tender for its annual supply of the anti-malarial artemether-lumefantrine to the lowest bidder, Ajanta Pharma, Kenya experienced wide stock-outs in part due to the company's inability to supply the order in full and on time. Similar problems could arise in Uganda. Despite Kenya's experience, Uganda has awarded its next tender for artemether-lumefantrine to Ajanta Pharma. Uganda is already facing wide stock-outs and risks exacerbating an already dire situation the longer it takes to fulfil the procurement contract. A tender process based primarily on price cannot account for a company's ability to consistently supply sufficient product in time. PMID:20028536

Environment-friendly drilling operation technology

NASA Astrophysics Data System (ADS)

Luo, Huaidong; Jing, Ning; Zhang, Yanna; Huang, Hongjun; Wei, Jun

2017-01-01

Under the circumstance that international safety and environmental standards being more and more stringent, drilling engineering is facing unprecedented challenges, the extensive traditional process flow is no longer accepted, the new safe and environment-friendly process is more suitable to the healthy development of the industry. In 2015, CNPCIC adopted environment-friendly drilling technology for the first time in the Chad region, ensured the safety of well control, at the same time increased the environmental protection measure, reduced the risk of environmental pollution what obtain the ratification from local government. This technology carries out recovery and disposal of crude oil, cuttings and mud without falling on the ground. The final products are used in road and well site construction, which realizes the reutilization of drilling waste, reduces the operating cost, and provides a strong technical support for cost-cutting and performance-increase of drilling engineering under low oil price.

Processing negative valence of word pairs that include a positive word.

PubMed

Itkes, Oksana; Mashal, Nira

2016-09-01

Previous research has suggested that cognitive performance is interrupted by negative relative to neutral or positive stimuli. We examined whether negative valence affects performance at the word or phrase level. Participants performed a semantic decision task on word pairs that included either a negative or a positive target word. In Experiment 1, the valence of the target word was congruent with the overall valence conveyed by the word pair (e.g., fat kid). As expected, response times were slower in the negative condition relative to the positive condition. Experiment 2 included target words that were incongruent with the overall valence of the word pair (e.g., fat salary). Response times were longer for word pairs whose overall valence was negative relative to positive, even though these word pairs included a positive word. Our findings support the Cognitive Primacy Hypothesis, according to which emotional valence is extracted after conceptual processing is complete.

SU-F-T-99: Data Visualization From a Treatment Planning Tracking System for Radiation Oncology

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cline, K; Kabat, C; Li, Y

2016-06-15

Purpose: A treatment planning process tracker database with input forms and a TV-viewable display webpage was developed and implemented in our clinic to collect time data points throughout the process. Tracking plan times is important because it directly affects the patient quality of care. Simply, the longer a patient waits after their initial simulation CT for treatment to begin, the more time the cancer has to progress. The tracker helps to drive workflow through the clinic, while the data collected can be used to understand and manage the process to find and eliminate inefficiencies. Methods: The overall process steps trackedmore » are CT-simulation, mark patient, draw normal contours, draw target volumes, create plan, and review/approve plan. Time stamps for task completion were extracted and used to generate a set of clinic metrics, among which include average time for each step in the process split apart by type of treatment, average time to completion for plans started in a given week, and individual overall completion time per plan. Results: Trends have been tracked for fourteen weeks of clinical data (196 plans). On average, drawing normal contours and target volumes is taking 2–5 times as long as creating the plan itself. This is potentially an issue because it could mean the process is taking too long initially, and it could be forcing the planning step to be done in a short amount of time. We also saw from our graphs that there appears to be no clear trend on the average amount of time per plan week-to-week. Conclusion: A tracker of this type has the potential to provide insight into how time is utilized in our clinic. By equipping our dosimetrists, radiation oncologists, and physicists with individualized metric sets, the tracker can help provide visibility and drive workflow. Funded in part by CPRIT (RP140105).« less

Nonremission and time to remission among remitters in major depressive disorder: Revisiting STAR*D.

PubMed

Mojtabai, Ramin

2017-12-01

Some individuals with major depressive disorder do not experience a remission even after one or more adequate treatment trials. In some others who experience remission, it happens at variable times. This study sought to estimate the prevalence of nonremission in a large sample of patient participating in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial and to identify correlates of nonremission and time to remission among remitters. Using data from 3,606 participants of STAR*D, the study used cure regression modeling to estimate nonremission and jointly model correlates of nonremission and time to remission among the remitters. Overall, 14.7% of the STAR*D participants were estimated to be nonremitters. Among remitters, the rate of remission declined over time. Greater severity, poorer physical health, and poor adherence with treatments were associated with both nonremission and a longer time to remission among the remitters in multivariable analyses, whereas unemployment, not having higher education, and longer duration of current episode were uniquely associated with nonremission; whereas, treatment in specialty mental health settings, poorer mental health functioning, and greater impairment in role functioning with a longer time to remission among remitters. Poor treatment adherence and poor physical health appear to be common risk factors for both nonremission and longer time to remission, highlighting the importance of integrated care models that address both medical and mental healthcare needs and interventions aimed at improving treatment adherence. © 2017 Wiley Periodicals, Inc.

Longer dialysis session length is associated with better intermediate outcomes and survival among patients on in-center three times per week hemodialysis: results from the Dialysis Outcomes and Practice Patterns Study (DOPPS)

PubMed Central

Tentori, Francesca; Zhang, Jinyao; Li, Yun; Karaboyas, Angelo; Kerr, Peter; Saran, Rajiv; Bommer, Juergen; Port, Friedrich; Akiba, Takashi; Pisoni, Ronald; Robinson, Bruce

2012-01-01

Background Longer dialysis session length (treatment time, TT) has been associated with better survival among hemodialysis (HD) patients. The impact of TT on clinical markers that may contribute to this survival advantage is not well known. Methods Using data from the international Dialysis Outcomes and Practice Patterns Study, we assessed the association of TT with clinical outcomes using both standard regression analyses and instrumental variable approaches. The study included 37 414 patients on in-center HD three times per week with prescribed TT from 120 to 420 min. Results Facility mean TT ranged from 214 min in the USA to 256 min in Australia–New Zealand. Accounting for country effects, mortality risk was lower for patients with longer TT {hazard ratio for every 30 min: all-cause mortality: 0.94 [95% confidence interval (CI): 0.92–0.97], cardiovascular mortality: 0.95 (95% CI: 0.91–0.98) and sudden death: 0.93 (95% CI: 0.88–0.98)}. Patients with longer TT had lower pre- and post-dialysis systolic blood pressure, greater intradialytic weight loss, higher hemoglobin (for the same erythropoietin dose), serum albumin and potassium and lower serum phosphorus and white blood cell counts. Similar associations were found using the instrumental variable approach, although the positive associations of TT with weight loss and potassium were lost. Conclusions Favorable levels of a variety of clinical markers may contribute to the better survival of patients receiving longer TT. These findings support longer TT prescription in the setting of in-center, three times per week HD. PMID:22431708

Estimation of T2* Relaxation Time of Breast Cancer: Correlation with Clinical, Imaging and Pathological Features

PubMed Central

Seo, Mirinae; Jahng, Geon-Ho; Sohn, Yu-Mee; Rhee, Sun Jung; Oh, Jang-Hoon; Won, Kyu-Yeoun

2017-01-01

Objective The purpose of this study was to estimate the T2* relaxation time in breast cancer, and to evaluate the association between the T2* value with clinical-imaging-pathological features of breast cancer. Materials and Methods Between January 2011 and July 2013, 107 consecutive women with 107 breast cancers underwent multi-echo T2*-weighted imaging on a 3T clinical magnetic resonance imaging system. The Student's t test and one-way analysis of variance were used to compare the T2* values of cancer for different groups, based on the clinical-imaging-pathological features. In addition, multiple linear regression analysis was performed to find independent predictive factors associated with the T2* values. Results Of the 107 breast cancers, 92 were invasive and 15 were ductal carcinoma in situ (DCIS). The mean T2* value of invasive cancers was significantly longer than that of DCIS (p = 0.029). Signal intensity on T2-weighted imaging (T2WI) and histologic grade of invasive breast cancers showed significant correlation with T2* relaxation time in univariate and multivariate analysis. Breast cancer groups with higher signal intensity on T2WI showed longer T2* relaxation time (p = 0.005). Cancer groups with higher histologic grade showed longer T2* relaxation time (p = 0.017). Conclusion The T2* value is significantly longer in invasive cancer than in DCIS. In invasive cancers, T2* relaxation time is significantly longer in higher histologic grades and high signal intensity on T2WI. Based on these preliminary data, quantitative T2* mapping has the potential to be useful in the characterization of breast cancer. PMID:28096732

Vulnerability and resilience to droughts in South-West USA: carbon allocation and impact on wood and evaporative anatomy

NASA Astrophysics Data System (ADS)

Guerin, M. F.; von Arx, G.; McDowell, N. G.; Pockman, W.; Andreu-Hayles, L.; Gentine, P.

2015-12-01

Survival and distribution of conifers across the globe will depend on their adaptive potential to the new climatic conditions (warmer, more droughts, heat waves). Recent studies predicting forest evolution have mainly focused on understanding tree mortality processes (hydraulic failure, carbon starvation, biotic stresses). These explicit causes of mortality are also the result of unsuccessful adaptation on a longer period. Using a 7 years drought-irrigation experiment in New Mexico, USA, we investigated the response to water availability on structure-function interactions at the tree level. Bridging dendrology and physiology on multiple individuals of local Pinion pine, we observe a structural dynamics in i) wood anatomy ii) evaporative anatomy and a resulting functional dynamics in i) leaf water potential and ii) water use efficiency on multiple time scales (daily to interannual). These results emphasize the tight coupling between carbon allocation and the surface hydrologic cycle on longer time scales and its impact on resilience and mortality, which is not included in current generation land-surface models. figure: Wood anatomy obtained from a 5.2mm core of a Pinion Edulis from the experimental site - illustrating the variability of the water transport capacities accross years

Structural imaging of nanoscale phonon transport in ferroelectrics excited by metamaterial-enhanced terahertz fields

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhu, Yi; Chen, Frank; Park, Joonkyu

Nanoscale phonon transport is a key process that governs thermal conduction in a wide range of materials and devices. Creating controlled phonon populations by resonant excitation at terahertz (THz) frequencies can drastically change the characteristics of nanoscale thermal transport and allow a direct real-space characterization of phonon mean-free paths. Using metamaterial-enhanced terahertz excitation, we tailored a phononic excitation by selectively populating low-frequency phonons within a nanoscale volume in a ferroelectric BaTiO3 thin film. Real-space time-resolved x-ray diffraction microscopy following THz excitation reveals ballistic phonon transport over a distance of hundreds of nm, two orders of magnitude longer than the averagedmore » phonon mean-free path in BaTiO3. On longer length scales, diffusive phonon transport dominates the recovery of the transient strain response, largely due to heat conduction into the substrate. The measured real-space phonon transport can be directly compared with the phonon mean-free path as predicted by molecular dynamics modeling. This time-resolved real-space visualization of THz-matter interactions opens up opportunities to engineer and image nanoscale transient structural states with new functionalities.« less

Structural imaging of nanoscale phonon transport in ferroelectrics excited by metamaterial-enhanced terahertz fields

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhu, Yi; Chen, Frank; Park, Joonkyu

Nanoscale phonon transport is a key process that governs thermal conduction in a wide range of materials and devices. Creating controlled phonon populations by resonant excitation at terahertz (THz) frequencies can drastically change the characteristics of nanoscale thermal transport and allow a direct real-space characterization of phonon mean-free paths. Using metamaterial-enhanced terahertz excitation, we tailored a phononic excitation by selectively populating low-frequency phonons within a nanoscale volume in a ferroelectric BaTiO 3 thin film. Real-space time-resolved x-ray diffraction microscopy following THz excitation reveals ballistic phonon transport over a distance of hundreds of nm, two orders of magnitude longer than themore » averaged phonon mean-free path in BaTiO 3. On longer length scales, diffusive phonon transport dominates the recovery of the transient strain response, largely due to heat conduction into the substrate. The measured real-space phonon transport can be directly compared with the phonon mean-free path as predicted by molecular dynamics modeling. In conclusion, this time-resolved real-space visualization of THz-matter interactions opens up opportunities to engineer and image nanoscale transient structural states with new functionalities.« less

Structural imaging of nanoscale phonon transport in ferroelectrics excited by metamaterial-enhanced terahertz fields

DOE PAGES

Zhu, Yi; Chen, Frank; Park, Joonkyu; ...

2017-11-16

Nanoscale phonon transport is a key process that governs thermal conduction in a wide range of materials and devices. Creating controlled phonon populations by resonant excitation at terahertz (THz) frequencies can drastically change the characteristics of nanoscale thermal transport and allow a direct real-space characterization of phonon mean-free paths. Using metamaterial-enhanced terahertz excitation, we tailored a phononic excitation by selectively populating low-frequency phonons within a nanoscale volume in a ferroelectric BaTiO 3 thin film. Real-space time-resolved x-ray diffraction microscopy following THz excitation reveals ballistic phonon transport over a distance of hundreds of nm, two orders of magnitude longer than themore » averaged phonon mean-free path in BaTiO 3. On longer length scales, diffusive phonon transport dominates the recovery of the transient strain response, largely due to heat conduction into the substrate. The measured real-space phonon transport can be directly compared with the phonon mean-free path as predicted by molecular dynamics modeling. In conclusion, this time-resolved real-space visualization of THz-matter interactions opens up opportunities to engineer and image nanoscale transient structural states with new functionalities.« less

Evaporation kinetics of surfactant solution droplets on rice (Oryza sativa) leaves

PubMed Central

Cao, Li-Dong; Zheng, Li; Xu, Jun; Li, Feng-Min; Huang, Qi-Liang

2017-01-01

The dynamics of evaporating sessile droplets on hydrophilic or hydrophobic surfaces is widely studied, and many models for these processes have been developed based on experimental evidence. However, few research has been explored on the evaporation of sessile droplets of surfactant or pesticide solutions on target crop leaves. Thus, in this paper the impact of surfactant concentrations on contact angle, contact diameter, droplet height, and evolution of the droplets’ evaporative volume on rice leaf surfaces have been investigated. The results indicate that the evaporation kinetics of surfactant droplets on rice leaves were influenced by both the surfactant concentrations and the hydrophobicity of rice leaf surfaces. When the surfactant concentration is lower than the surfactant CMC (critical micelle concentration), the droplet evaporation time is much longer than that of the high surfactant concentration. This is due to the longer existence time of a narrow wedge region under the lower surfactant concentration, and such narrow wedge region further restricts the droplet evaporation. Besides, our experimental data are shown to roughly collapse onto theoretical curves based on the model presented by Popov. This study could supply theoretical data on the evaporation of the adjuvant or pesticide droplets for practical applications in agriculture. PMID:28472108

Forecasting Sensorimotor Adaptability from Baseline Inter-Trial Correlations

NASA Technical Reports Server (NTRS)

Beaton, K. H.; Bloomberg, J. J.

2014-01-01

One of the greatest challenges surrounding adaptation to the spaceflight environment is the large variability in symptoms, and corresponding functional impairments, from one crewmember to the next. This renders preflight training and countermeasure development difficult, as a "one-size-fits-all" approach is inappropriate. Therefore, it would be highly advantageous to know ahead of time which crewmembers might have more difficulty adjusting to the novel g-levels inherent to spaceflight. Such knowledge could guide individually customized countermeasures, which would enable more efficient use of crew time, both preflight and inflight, and provide better outcomes. The primary goal of this project is to look for a baseline performance metric that can forecast sensorimotor adaptability without exposure to an adaptive stimulus. We propose a novel hypothesis that considers baseline inter-trial correlations, the trial-to-trial fluctuations in motor performance, as a predictor of individual sensorimotor adaptive capabilities. To-date, a strong relationship has been found between baseline inter-trial correlations and adaptability in two oculomotor systems. For this project, we will explore an analogous predictive mechanism in the locomotion system. METHODS: Baseline Inter-trial Correlations: Inter-trial correlations specify the relationships among repeated trials of a given task that transpire as a consequence of correcting for previous performance errors over multiple timescales. We can quantify the strength of inter-trial correlations by measuring the decay of the autocorrelation function (ACF), which describes how rapidly information from past trials is "forgotten." Processes whose ACFs decay more slowly exhibit longer-term inter-trial correlations (longer memory processes), while processes whose ACFs decay more rapidly exhibit shorterterm inter-trial correlations (shorter memory processes). Longer-term correlations reflect low-frequency activity, which is more easily measured in the frequency domain. Therefore, we use the power spectrum (PS), which is the Fourier transform of the ACF, to describe our inter-trial correlations. The decay of the PS yields a straight line on a log-log frequency plot, which we quantify by Beta = - (slope of PS on log-log axes). Hence, Beta is a measure of the strength of inter- trial correlations in the baseline data. Larger Beta values are indicative of longer inter-trial correlations. Experimental Approach: We will begin by performing a retrospective analysis of treadmill-gait adaptation data previously collected by Dr. Bloomberg and colleagues. Specifically, we will quantify the strength of inter-trial correlations in the baseline step cadence and heart rate data and compare it to the locomotor adaptability performance results already described by these investigators. Incorporating these datasets will also allow us to explore the applicability of (and potential limitations surrounding) the use of Beta in forecasting physiological performance. We will also perform a new experiment, in which Beta will be derived from baseline data collected during over-ground (non-treadmill) walking, which will enable us to consider locomotor performance, through the parameter Beta, under the most functionallyrelevant, natural gait condition. This experiment will incorporate two baseline and five post-training over-ground locomotion tests to explore the consistency and potential adaptability of the Beta values themselves. HYPOTHESES: We hypothesize that the strength of baseline inter-trial correlations of step cadence and heart rate will relate to locomotor adaptability. Specifically, we anticipate that individuals who show weaker longer-term inter-trial correlations in baseline step cadence data will be the better adaptors, as step cadence can be modified in real-time (i.e., online corrections are an inherent property of the locomotor system; analogous to results observed in the VOR). Conversely, because heart rate is not altered mid-beat, we expect that individuals who demonstrate stronger longer-term correlations in heart rate will be the better adaptors (analogous to results observed in the saccadic system). CONCLUSIONS: At the conclusion of this project we hope to uncover a baseline predictor of locomotor adaptability. If our hypotheses hold true, our results will demonstrate that the temporal structure of baseline behavioral data contains important information that may aid in forecasting adaptive capacities. The ability to predict such adaptability in the sensorimotor system has significant implications for spaceflight, where astronauts must adjust their motor programs following a change in g-level to retain movement accuracy.

The impact of sleep on true and false memory across long delays.

PubMed

Pardilla-Delgado, Enmanuelle; Payne, Jessica D

2017-01-01

While the influence of sleep on memory has a long history, sleep's role in the formation of false memories is less clear. Moreover, virtually nothing is known about the development of false memories beyond delays of about 12h. Here, for the first time, we assess post-sleep development of true and false memories across longer delay intervals of 24 and 48h. Although technically a false memory, remembering information that is related to the theme, or gist, of an experience can be considered an adaptive process. Some evidence suggests that sleep, compared to a wake period, increases both true and gist-based false memories in the Deese-Roediger-McDermott (DRM) task, but not all studies have returned this result, and most studies cannot rule out the possibility that sleep is merely protecting the information from interference, as opposed to actively aiding its consolidation. Here, to equate amount of time spent awake and asleep across groups, we assess how the positioning of sleep relative to memory encoding impacts retention across longer delays of 24 and 48h. Participants encoded 16 DRM lists in the morning (WAKE 1st Groups) or evening (SLEEP 1st Groups), and were tested either 24 or 48h later at the same time of day. Results demonstrate that true memory is better when participants sleep soon after learning. Sleeping first also increased false memory, but only in low performers. Importantly, and similar to previous studies, we found a negative correlation between slow-wave sleep (SWS) and false memory, suggesting that SWS may be detrimental for semantic/gist processing. Copyright © 2016 Elsevier Inc. All rights reserved.

Investigating task inhibition in children versus adults: A diffusion model analysis.

PubMed

Schuch, Stefanie; Konrad, Kerstin

2017-04-01

One can take n-2 task repetition costs as a measure of inhibition on the level of task sets. When switching back to a Task A after only one intermediate trial (ABA task sequence), Task A is thought to still be inhibited, leading to performance costs relative to task sequences where switching back to Task A is preceded by at least two intermediary trials (CBA). The current study investigated differences in inhibitory ability between children and adults by comparing n-2 task repetition costs in children (9-11years of age, N=32) and young adults (21-30years of age, N=32). The mean reaction times and error rate differences between ABA and CBA sequences did not differ between the two age groups. However, diffusion model analysis revealed that different cognitive processes contribute to the inhibition effect in the two age groups: The adults, but not the children, showed a smaller drift rate in ABA than in CBA, suggesting that persisting task inhibition is associated with slower response selection in adults. In children, non-decision time was longer in ABA than in CBA, possibly reflecting longer task preparation in ABA than in CBA. In addition, Ex-Gaussian functions were fitted to the distributions of correct reaction times. In adults, the ABA-CBA difference was reflected in the exponential parameter of the distribution; in children, the ABA-CBA difference was found in the Gaussian mu parameter. Hence, Ex-Gaussian analysis, although noisier, was generally in line with diffusion model analysis. Taken together, the data suggest that the task inhibition effect found in mean performance is mediated by different cognitive processes in children versus adults. Copyright © 2016 Elsevier Inc. All rights reserved.

A Time-Domain CMOS Oscillator-Based Thermostat with Digital Set-Point Programming

PubMed Central

Chen, Chun-Chi; Lin, Shih-Hao

2013-01-01

This paper presents a time-domain CMOS oscillator-based thermostat with digital set-point programming [without a digital-to-analog converter (DAC) or external resistor] to achieve on-chip thermal management of modern VLSI systems. A time-domain delay-line-based thermostat with multiplexers (MUXs) was used to substantially reduce the power consumption and chip size, and can benefit from the performance enhancement due to the scaling down of fabrication processes. For further cost reduction and accuracy enhancement, this paper proposes a thermostat using two oscillators that are suitable for time-domain curvature compensation instead of longer linear delay lines. The final time comparison was achieved using a time comparator with a built-in custom hysteresis to generate the corresponding temperature alarm and control. The chip size of the circuit was reduced to 0.12 mm2 in a 0.35-μm TSMC CMOS process. The thermostat operates from 0 to 90 °C, and achieved a fine resolution better than 0.05 °C and an improved inaccuracy of ± 0.6 °C after two-point calibration for eight packaged chips. The power consumption was 30 μW at a sample rate of 10 samples/s. PMID:23385403

Scalability, Timing, and System Design Issues for Intrinsic Evolvable Hardware

NASA Technical Reports Server (NTRS)

Hereford, James; Gwaltney, David

2004-01-01

In this paper we address several issues pertinent to intrinsic evolvable hardware (EHW). The first issue is scalability; namely, how the design space scales as the programming string for the programmable device gets longer. We develop a model for population size and the number of generations as a function of the programming string length, L, and show that the number of circuit evaluations is an O(L2) process. We compare our model to several successful intrinsic EHW experiments and discuss the many implications of our model. The second issue that we address is the timing of intrinsic EHW experiments. We show that the processing time is a small part of the overall time to derive or evolve a circuit and that major improvements in processor speed alone will have only a minimal impact on improving the scalability of intrinsic EHW. The third issue we consider is the system-level design of intrinsic EHW experiments. We review what other researchers have done to break the scalability barrier and contend that the type of reconfigurable platform and the evolutionary algorithm are tied together and impose limits on each other.

Life Expectancy and Human Capital Investments: Evidence from Maternal Mortality Declines. NBER Working Paper No. 13947

ERIC Educational Resources Information Center

Jayachandran, Seema; Lleras-Muney, Adriana

2008-01-01

Longer life expectancy should encourage human capital accumulation, since a longer time horizon increases the value of investments that pay out over time. Previous work has been unable to determine the empirical importance of this life-expectancy effect due to the difficulty of isolating it from other effects of health on education. We examine a…

How does temperature affect forest "fungus breath"? Diurnal non-exponential temperature-respiration relationship, and possible longer-term acclimation in fungal sporocarps

Treesearch

Erik A. Lilleskov

2017-01-01

Fungal respiration contributes substantially to ecosystem respiration, yet its field temperature response is poorly characterized. I hypothesized that at diurnal time scales, temperature-respiration relationships would be better described by unimodal than exponential models, and at longer time scales both Q10 and mass-specific respiration at 10 °...

Whole-plant capacitance, embolism resistance and slow transpiration rates all contribute to longer desiccation times in woody angiosperms from arid and wet habitats

USDA-ARS?s Scientific Manuscript database

Low water potentials in xylem can result in damaging levels of cavitation, yet little is understood about which hydraulic traits have most influence in delaying the onset of hydraulic dysfunction during periods of drought. We examined three traits contributing to longer desiccation times in excised ...

Racial/ethnic disparities in emergency department waiting time for stroke patients in the United States.

PubMed

Karve, Sudeep J; Balkrishnan, Rajesh; Mohammad, Yousef M; Levine, Deborah A

2011-01-01

Emergency department waiting time (EDWT), the time from arrival at the ED to evaluation by an emergency physician, is a critical component of acute stroke care. We assessed racial/ethnic differences in EDWT in a national sample of patients with ischemic or hemorrhagic stroke. We identified 543 ED visits for ischemic stroke (International Classification of Diseases, Ninth Revision, Clinical Modification [ICD-9-CM] codes 433.x1, 434.xx, and 436.xx) and hemorrhagic stroke (ICD-9-CM codes 430.xx, 431.xx, and 432.xx) in persons age ≥ 18 years representing 2.1 million stroke-related ED visits in the United States using the National Hospital Ambulatory Medical Care Survey for years 1997-2000 and 2003-2005. Using linear regression (outcome, log-transformed EDWT) and logistic regression (outcome, EDWT > 10 minutes, based on National Institute of Neurological Disorders and Stroke guidelines), we adjusted associations between EDWT and race/ethnicity (non-Hispanic whites [designated whites herein], non-Hispanic blacks [blacks], and Hispanics) for age, sex, region, mode of transportation, insurance, hospital characteristics, triage status, hospital admission, stroke type, and survey year. Compared with whites, blacks had a longer EDWT in univariate analysis (67% longer, P = .03) and multivariate analysis (62% longer, P = .03), but Hispanics had a similar EDWT in both univariate analysis (31% longer, P = .65) and multivariate analysis (5% longer, P = .91). Longer EDWT was also seen with nonambulance mode of arrival, urban hospitals, or nonemergency triage. Race was significantly associated with EDWT > 10 minutes (whites, 55% [referent]; blacks, 70% [P = .03]; Hispanics, 62% [P = .53]). These differences persisted after adjustment (blacks: odds ratio [OR] = 2.08, 95% confidence interval [CI] = 1.05-4.09; Hispanics: OR = 1.07, 95% CI = 0.52-2.22). Blacks, but not Hispanics, had significantly longer EDWT than whites. The longer EDWT in black stroke patients may lead to treatment delays and sub-optimal stroke care. Published by Elsevier Inc.

Dissecting delays in trauma care using corporate lean six sigma methodology.

PubMed

Parks, Jennifer K; Klein, Jorie; Frankel, Heidi L; Friese, Randall S; Shafi, Shahid

2008-11-01

The Institute of Medicine has identified trauma center overcrowding as a crisis. We applied corporate Lean Six Sigma methodology to reduce overcrowding by quantifying patient dwell times in trauma resuscitation units (TRU) and to identify opportunities for reducing them. TRU dwell time of all patients treated at a Level I trauma center were measured prospectively during a 3-month period (n = 1,184). Delays were defined as TRU dwell time >6 hours. Using personnel trained in corporate Lean Six Sigma methodology, we created a detailed process map of patient flow through our TRU and measured time spent at each step prospectively during a 24/7 week-long time study (n = 43). Patients with TRU dwell time below the median (3 hours) were compared with those with longer dwell times to identify opportunities for improvement. TRU delays occurred in 183 of 1,184 trauma patients (15%), and peaked on days with >15 patients or with presence of five simultaneous patients. However, 135 delays (74%) occurred on days when

Planning ahead in public health? A qualitative study of the time horizons used in public health decision-making

PubMed Central

Taylor-Robinson, David C; Milton, Beth; Lloyd-Williams, Ffion; O'Flaherty, Martin; Capewell, Simon

2008-01-01

Background In order to better understand factors that influence decisions for public health, we undertook a qualitative study to explore issues relating to the time horizons used in decision-making. Methods Qualitative study using semi-structured interviews. 33 individuals involved in the decision making process around coronary heart disease were purposively sampled from the UK National Health Service (national, regional and local levels), academia and voluntary organizations. Analysis was based on the framework method using N-VIVO software. Interviews were transcribed, coded and emergent themes identified. Results Many participants suggested that the timescales for public health decision-making are too short. Commissioners and some practitioners working at the national level particularly felt constrained in terms of planning for the long-term. Furthermore respondents felt that longer term planning was needed to address the wider determinants of health and to achieve societal level changes. Three prominent 'systems' issues were identified as important drivers of short term thinking: the need to demonstrate impact within the 4 year political cycle; the requirement to 'balance the books' within the annual commissioning cycle and the disruption caused by frequent re-organisations within the health service. In addition respondents suggested that the tools and evidence base for longer term planning were not well established. Conclusion Many public health decision and policy makers feel that the timescales for decision-making are too short. Substantial systemic barriers to longer-term planning exist. Policy makers need to look beyond short-term targets and budget cycles to secure investment for long-term improvement in public health. PMID:19094194

Planning ahead in public health? A qualitative study of the time horizons used in public health decision-making.

PubMed

Taylor-Robinson, David C; Milton, Beth; Lloyd-Williams, Ffion; O'Flaherty, Martin; Capewell, Simon

2008-12-18

In order to better understand factors that influence decisions for public health, we undertook a qualitative study to explore issues relating to the time horizons used in decision-making. Qualitative study using semi-structured interviews. 33 individuals involved in the decision making process around coronary heart disease were purposively sampled from the UK National Health Service (national, regional and local levels), academia and voluntary organizations. Analysis was based on the framework method using N-VIVO software. Interviews were transcribed, coded and emergent themes identified. Many participants suggested that the timescales for public health decision-making are too short. Commissioners and some practitioners working at the national level particularly felt constrained in terms of planning for the long-term. Furthermore respondents felt that longer term planning was needed to address the wider determinants of health and to achieve societal level changes. Three prominent 'systems' issues were identified as important drivers of short term thinking: the need to demonstrate impact within the 4 year political cycle; the requirement to 'balance the books' within the annual commissioning cycle and the disruption caused by frequent re-organisations within the health service. In addition respondents suggested that the tools and evidence base for longer term planning were not well established. Many public health decision and policy makers feel that the timescales for decision-making are too short. Substantial systemic barriers to longer-term planning exist. Policy makers need to look beyond short-term targets and budget cycles to secure investment for long-term improvement in public health.

Drying characteristic, enzyme inactivation and browning pigmentation kinetics of controlled humidity-convective drying of banana slices

NASA Astrophysics Data System (ADS)

Sarpong, Frederick; Yu, Xiaojie; Zhou, Cunshan; Oteng-Darko, Patricia; Amenorfe, Leticia Peace; Wu, Bengang; Bai, Junwen; Ma, Haile

2018-04-01

Investigating the kinetics of enzyme activities and browning indexes in food are very essential in understanding the enzyme inactivation and browning pigmentation reaction during drying processing. In order to understand and predict accurately the enzyme inactivation and browning pigmentation of banana slices using Relative Humidity (RH)-convective hot air dryer aided by ultrasound (US) pretreatment, this study was conducted. Drying was carried out with 20 kHz frequency of US-pretreatment using three durations (10 20 and 30 min) and RH (10 20 and 30%) conditions at 70 °C and 2.0 m/s air velocity. The kinetic study of both enzyme inactivation and browning pigmentation results were compared to their relevance of fit in terms of coefficient of correlation (R2), the root mean square error (RMSE) and the reduced chi-square (χ 2). First order and second-order polynomial kinetic model fitted well for enzyme inactivation and browning indexes respectively. Both enzymes inactivation kinetics and enzymatic browning index (EBI) declined significantly (p < 0.05) with increasing drying time in all drying conditions and rate of decrease intensified in longer US-pretreatment duration and lower RH conditions. However, shorter US-pretreatment duration and higher RH conditions reduced the non- enzymatic browning index (NBI) significantly. Again, longer US-pretreatment duration and lower RH shortened the drying time but adversely created more microspores from the micrograph study. Longer US pretreatment and lower RH decrease significantly (p < 0.05) the L* and b* values whereas the a* values was increased.

The impact of a streamlined funding application process on application time: two cross-sectional surveys of Australian researchers.

PubMed

Barnett, Adrian G; Graves, Nicholas; Clarke, Philip; Herbert, Danielle

2015-01-16

To examine if streamlining a medical research funding application process saved time for applicants. Cross-sectional surveys before and after the streamlining. The National Health and Medical Research Council (NHMRC) of Australia. Researchers who submitted one or more NHMRC Project Grant applications in 2012 or 2014. Average researcher time spent preparing an application and the total time for all applications in working days. The average time per application increased from 34 working days before streamlining (95% CI 33 to 35) to 38 working days after streamlining (95% CI 37 to 39; mean difference 4 days, bootstrap p value <0.001). The estimated total time spent by all researchers on applications after streamlining was 614 working years, a 67-year increase from before streamlining. Streamlined applications were shorter but took longer to prepare on average. Researchers may be allocating a fixed amount of time to preparing funding applications based on their expected return, or may be increasing their time in response to increased competition. Many potentially productive years of researcher time are still being lost to preparing failed applications. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

The processing of consonants and vowels during letter identity and letter position assignment in visual-word recognition: an ERP study.

PubMed

Vergara-Martínez, Marta; Perea, Manuel; Marín, Alejandro; Carreiras, Manuel

2011-09-01

Recent research suggests that there is a processing distinction between consonants and vowels in visual-word recognition. Here we conjointly examine the time course of consonants and vowels in processes of letter identity and letter position assignment. Event related potentials (ERPs) were recorded while participants read words and pseudowords in a lexical decision task. The stimuli were displayed under different conditions in a masked priming paradigm with a 50-ms SOA: (i) identity/baseline condition e.g., chocolate-CHOCOLATE); (ii) vowels-delayed condition (e.g., choc_l_te-CHOCOLATE); (iii) consonants-delayed condition (cho_o_ate-CHOCOLATE); (iv) consonants-transposed condition (cholocate-CHOCOLATE); (v) vowels-transposed condition (chocalote-CHOCOLATE), and (vi) unrelated condition (editorial-CHOCOLATE). Results showed earlier ERP effects and longer reaction times for the delayed-letter compared to the transposed-letter conditions. Furthermore, at early stages of processing, consonants may play a greater role during letter identity processing. Differences between vowels and consonants regarding letter position assignment are discussed in terms of a later phonological level involved in lexical retrieval. Copyright © 2010 Elsevier Inc. All rights reserved.

Induction and Consolidation of Calcium-Based Homo- and Heterosynaptic Potentiation and Depression

PubMed Central

Li, Yinyun; Kulvicius, Tomas; Tetzlaff, Christian

2016-01-01

The adaptive mechanisms of homo- and heterosynaptic plasticity play an important role in learning and memory. In order to maintain plasticity-induced changes for longer time scales (up to several days), they have to be consolidated by transferring them from a short-lasting early-phase to a long-lasting late-phase state. The underlying processes of this synaptic consolidation are already well-known for homosynaptic plasticity, however, it is not clear whether the same processes also enable the induction and consolidation of heterosynaptic plasticity. In this study, by extending a generic calcium-based plasticity model with the processes of synaptic consolidation, we show in simulations that indeed heterosynaptic plasticity can be induced and, furthermore, consolidated by the same underlying processes as for homosynaptic plasticity. Furthermore, we show that by local diffusion processes the heterosynaptic effect can be restricted to a few synapses neighboring the homosynaptically changed ones. Taken together, this generic model reproduces many experimental results of synaptic tagging and consolidation, provides several predictions for heterosynaptic induction and consolidation, and yields insights into the complex interactions between homo- and heterosynaptic plasticity over a broad variety of time (minutes to days) and spatial scales (several micrometers). PMID:27560350

Reinventing The Design Process: Teams and Models

NASA Technical Reports Server (NTRS)

Wall, Stephen D.

1999-01-01

The future of space mission designing will be dramatically different from the past. Formerly, performance-driven paradigms emphasized data return with cost and schedule being secondary issues. Now and in the future, costs are capped and schedules fixed-these two variables must be treated as independent in the design process. Accordingly, JPL has redesigned its design process. At the conceptual level, design times have been reduced by properly defining the required design depth, improving the linkages between tools, and managing team dynamics. In implementation-phase design, system requirements will be held in crosscutting models, linked to subsystem design tools through a central database that captures the design and supplies needed configuration management and control. Mission goals will then be captured in timelining software that drives the models, testing their capability to execute the goals. Metrics are used to measure and control both processes and to ensure that design parameters converge through the design process within schedule constraints. This methodology manages margins controlled by acceptable risk levels. Thus, teams can evolve risk tolerance (and cost) as they would any engineering parameter. This new approach allows more design freedom for a longer time, which tends to encourage revolutionary and unexpected improvements in design.

NASA earth science and applications division: The program and plans for FY 1988-1989-1990

NASA Technical Reports Server (NTRS)

1988-01-01

Described here are the Division's research goals, priorities and emphases for the next several years and an outline of longer term plans. Included are highlights of recent accomplishments, current activities in FY 1988, research emphases in FY 1989, and longer term future plans. Data and information systems, the Geodynamics Program, the Land Processes Program, the Oceanic Processes Program, the Atmospheric Dynamics and Radiation Program, the Atmospheric Chemistry Program, and space flight programs are among the topic covered.

Study of thermally-induced optical bistability and the role of surface treatments in Si-based mid-infrared photonic crystal cavities.

PubMed

Shankar, Raji; Bulu, Irfan; Leijssen, Rick; Lončar, Marko

2011-11-21

We report the observation of optical bistability in Si-based photonic crystal cavities operating around 4.5 µm. Time domain measurements indicate that the source of this optical bistability is thermal, with a time constant on the order of 5 µs. Quality (Q) factor improvement is shown by the use of surface treatments (wet processes and annealing), resulting in a significant increase in Q-factor, which in our best devices is on the order of ~45,000 at 4.48 µm. After annealing in a N(2) environment, optical bistability is no longer seen in our cavities. © 2011 Optical Society of America

Low-field anomalous magnetic phase in the kagome-lattice shandite C o3S n2S2

NASA Astrophysics Data System (ADS)

Kassem, Mohamed A.; Tabata, Yoshikazu; Waki, Takeshi; Nakamura, Hiroyuki

2017-07-01

The magnetization process of single crystals of the metallic kagome ferromagnet C o3S n2S2 was carefully measured via magnetization and ac susceptibility. Field-dependent anomalous transitions observed in low fields indicate the presence of an unconventional magnetic phase just below the Curie temperature, TC. The magnetic phase diagrams in low magnetic fields along different crystallographic directions were determined for the first time. The magnetic relaxation measurements at various frequencies covering five orders of magnitude from 0.01 to 1000 Hz indicate markedly slow spin dynamics only in the anomalous phase with characteristic relaxation times longer than 10 s.

Persistence of the Intuitive Conception of Living Things in Adolescence

NASA Astrophysics Data System (ADS)

Babai, Reuven; Sekal, Rachel; Stavy, Ruth

2010-02-01

This study investigated whether intuitive, naive conceptions of "living things" based on objects' mobility (movement = alive) persist into adolescence and affect 10th graders' accuracy of responses and reaction times during object classification. Most of the 58 students classified the test objects correctly as living/nonliving, yet they demonstrated significantly longer reaction times for classifying plants compared to animals and for classifying dynamic objects compared to static inanimate objects. Findings indicated that, despite prior learning in biology, the intuitive conception of living things persists up to age 15-16 years, affecting related reasoning processes. Consideration of these findings may help educators in their decisions about the nature of examples they use in their classrooms.

Extended Operation of Turbojet Engine with Pentaborane

NASA Technical Reports Server (NTRS)

Useller, James W; Jones, William L

1957-01-01

A full-scale turbojet engine was operated with pentaborane fuel continuously for 22 minutes at conditions simulating flight at a Mach number of 0.8 at an altitude of 50,000 feet. This period of operation is approximately three times longer than previously reported operation times. Although the specific fuel consumption was reduced from 1.3 with JP-4 fuel to 0.98 with pentaborane, a 13.2-percent reduction in net thrust was also encountered. A portion of this thrust loss is potentially recoverable with proper design of the engine components. The boron oxide deposition and erosion processes within the engine approached an equilibrium condition after approximately 22 minutes of operation with pentaborane.

Imaging different components of a tectonic tremor sequence in southwestern Japan using an automatic statistical detection and location method

NASA Astrophysics Data System (ADS)

Poiata, Natalia; Vilotte, Jean-Pierre; Bernard, Pascal; Satriano, Claudio; Obara, Kazushige

2018-06-01

In this study, we demonstrate the capability of an automatic network-based detection and location method to extract and analyse different components of tectonic tremor activity by analysing a 9-day energetic tectonic tremor sequence occurring at the downdip extension of the subducting slab in southwestern Japan. The applied method exploits the coherency of multiscale, frequency-selective characteristics of non-stationary signals recorded across the seismic network. Use of different characteristic functions, in the signal processing step of the method, allows to extract and locate the sources of short-duration impulsive signal transients associated with low-frequency earthquakes and of longer-duration energy transients during the tectonic tremor sequence. Frequency-dependent characteristic functions, based on higher-order statistics' properties of the seismic signals, are used for the detection and location of low-frequency earthquakes. This allows extracting a more complete (˜6.5 times more events) and time-resolved catalogue of low-frequency earthquakes than the routine catalogue provided by the Japan Meteorological Agency. As such, this catalogue allows resolving the space-time evolution of the low-frequency earthquakes activity in great detail, unravelling spatial and temporal clustering, modulation in response to tide, and different scales of space-time migration patterns. In the second part of the study, the detection and source location of longer-duration signal energy transients within the tectonic tremor sequence is performed using characteristic functions built from smoothed frequency-dependent energy envelopes. This leads to a catalogue of longer-duration energy sources during the tectonic tremor sequence, characterized by their durations and 3-D spatial likelihood maps of the energy-release source regions. The summary 3-D likelihood map for the 9-day tectonic tremor sequence, built from this catalogue, exhibits an along-strike spatial segmentation of the long-duration energy-release regions, matching the large-scale clustering features evidenced from the low-frequency earthquake's activity analysis. Further examination of the two catalogues showed that the extracted short-duration low-frequency earthquakes activity coincides in space, within about 10-15 km distance, with the longer-duration energy sources during the tectonic tremor sequence. This observation provides a potential constraint on the size of the longer-duration energy-radiating source region in relation with the clustering of low-frequency earthquakes activity during the analysed tectonic tremor sequence. We show that advanced statistical network-based methods offer new capabilities for automatic high-resolution detection, location and monitoring of different scale-components of tectonic tremor activity, enriching existing slow earthquakes catalogues. Systematic application of such methods to large continuous data sets will allow imaging the slow transient seismic energy-release activity at higher resolution, and therefore, provide new insights into the underlying multiscale mechanisms of slow earthquakes generation.

Imaging different components of a tectonic tremor sequence in southwestern Japan using an automatic statistical detection and location method

NASA Astrophysics Data System (ADS)

Poiata, Natalia; Vilotte, Jean-Pierre; Bernard, Pascal; Satriano, Claudio; Obara, Kazushige

2018-02-01

In this study, we demonstrate the capability of an automatic network-based detection and location method to extract and analyse different components of tectonic tremor activity by analysing a 9-day energetic tectonic tremor sequence occurring at the down-dip extension of the subducting slab in southwestern Japan. The applied method exploits the coherency of multi-scale, frequency-selective characteristics of non-stationary signals recorded across the seismic network. Use of different characteristic functions, in the signal processing step of the method, allows to extract and locate the sources of short-duration impulsive signal transients associated with low-frequency earthquakes and of longer-duration energy transients during the tectonic tremor sequence. Frequency-dependent characteristic functions, based on higher-order statistics' properties of the seismic signals, are used for the detection and location of low-frequency earthquakes. This allows extracting a more complete (˜6.5 times more events) and time-resolved catalogue of low-frequency earthquakes than the routine catalogue provided by the Japan Meteorological Agency. As such, this catalogue allows resolving the space-time evolution of the low-frequency earthquakes activity in great detail, unravelling spatial and temporal clustering, modulation in response to tide, and different scales of space-time migration patterns. In the second part of the study, the detection and source location of longer-duration signal energy transients within the tectonic tremor sequence is performed using characteristic functions built from smoothed frequency-dependent energy envelopes. This leads to a catalogue of longer-duration energy sources during the tectonic tremor sequence, characterized by their durations and 3-D spatial likelihood maps of the energy-release source regions. The summary 3-D likelihood map for the 9-day tectonic tremor sequence, built from this catalogue, exhibits an along-strike spatial segmentation of the long-duration energy-release regions, matching the large-scale clustering features evidenced from the low-frequency earthquake's activity analysis. Further examination of the two catalogues showed that the extracted short-duration low-frequency earthquakes activity coincides in space, within about 10-15 km distance, with the longer-duration energy sources during the tectonic tremor sequence. This observation provides a potential constraint on the size of the longer-duration energy-radiating source region in relation with the clustering of low-frequency earthquakes activity during the analysed tectonic tremor sequence. We show that advanced statistical network-based methods offer new capabilities for automatic high-resolution detection, location and monitoring of different scale-components of tectonic tremor activity, enriching existing slow earthquakes catalogues. Systematic application of such methods to large continuous data sets will allow imaging the slow transient seismic energy-release activity at higher resolution, and therefore, provide new insights into the underlying multi-scale mechanisms of slow earthquakes generation.

Lithium diffusion in polyether ether ketone and polyimide stimulated by in situ electron irradiation and studied by the neutron depth profiling method

NASA Astrophysics Data System (ADS)

Vacik, J.; Hnatowicz, V.; Attar, F. M. D.; Mathakari, N. L.; Dahiwale, S. S.; Dhole, S. D.; Bhoraskar, V. N.

2014-10-01

Diffusion of lithium from a LiCl aqueous solution into polyether ether ketone (PEEK) and polyimide (PI) assisted by in situ irradiation with 6.5 MeV electrons was studied by the neutron depth profiling method. The number of the Li atoms was found to be roughly proportional to the diffusion time. Regardless of the diffusion time, the measured depth profiles in PEEK exhibit a nearly exponential form, indicating achievement of a steady-state phase of a diffusion-reaction process specified in the text. The form of the profiles in PI is more complex and it depends strongly on the diffusion time. For the longer diffusion time, the profile consists of near-surface bell-shaped part due to Fickian-like diffusion and deeper exponential part.

Daily rainfall forecasting for one year in a single run using Singular Spectrum Analysis

NASA Astrophysics Data System (ADS)

Unnikrishnan, Poornima; Jothiprakash, V.

2018-06-01

Effective modelling and prediction of smaller time step rainfall is reported to be very difficult owing to its highly erratic nature. Accurate forecast of daily rainfall for longer duration (multi time step) may be exceptionally helpful in the efficient planning and management of water resources systems. Identification of inherent patterns in a rainfall time series is also important for an effective water resources planning and management system. In the present study, Singular Spectrum Analysis (SSA) is utilized to forecast the daily rainfall time series pertaining to Koyna watershed in Maharashtra, India, for 365 days after extracting various components of the rainfall time series such as trend, periodic component, noise and cyclic component. In order to forecast the time series for longer time step (365 days-one window length), the signal and noise components of the time series are forecasted separately and then added together. The results of the study show that the method of SSA could extract the various components of the time series effectively and could also forecast the daily rainfall time series for longer duration such as one year in a single run with reasonable accuracy.

Large scale atomistic simulation of single-layer graphene growth on Ni(111) surface: molecular dynamics simulation based on a new generation of carbon-metal potential

NASA Astrophysics Data System (ADS)

Xu, Ziwei; Yan, Tianying; Liu, Guiwu; Qiao, Guanjun; Ding, Feng

2015-12-01

To explore the mechanism of graphene chemical vapor deposition (CVD) growth on a catalyst surface, a molecular dynamics (MD) simulation of carbon atom self-assembly on a Ni(111) surface based on a well-designed empirical reactive bond order potential was performed. We simulated single layer graphene with recorded size (up to 300 atoms per super-cell) and reasonably good quality by MD trajectories up to 15 ns. Detailed processes of graphene CVD growth, such as carbon atom dissolution and precipitation, formation of carbon chains of various lengths, polygons and small graphene domains were observed during the initial process of the MD simulation. The atomistic processes of typical defect healing, such as the transformation from a pentagon into a hexagon and from a pentagon-heptagon pair (5|7) to two adjacent hexagons (6|6), were revealed as well. The study also showed that higher temperature and longer annealing time are essential to form high quality graphene layers, which is in agreement with experimental reports and previous theoretical results.To explore the mechanism of graphene chemical vapor deposition (CVD) growth on a catalyst surface, a molecular dynamics (MD) simulation of carbon atom self-assembly on a Ni(111) surface based on a well-designed empirical reactive bond order potential was performed. We simulated single layer graphene with recorded size (up to 300 atoms per super-cell) and reasonably good quality by MD trajectories up to 15 ns. Detailed processes of graphene CVD growth, such as carbon atom dissolution and precipitation, formation of carbon chains of various lengths, polygons and small graphene domains were observed during the initial process of the MD simulation. The atomistic processes of typical defect healing, such as the transformation from a pentagon into a hexagon and from a pentagon-heptagon pair (5|7) to two adjacent hexagons (6|6), were revealed as well. The study also showed that higher temperature and longer annealing time are essential to form high quality graphene layers, which is in agreement with experimental reports and previous theoretical results. Electronic supplementary information (ESI) available. See DOI: 10.1039/c5nr06016h

Comparison of TiO₂ and ZnO solar cells sensitized with an indoline dye: time-resolved laser spectroscopy studies of partial charge separation processes.

PubMed

Sobuś, Jan; Burdziński, Gotard; Karolczak, Jerzy; Idígoras, Jesús; Anta, Juan A; Ziółek, Marcin

2014-03-11

Time-resolved laser spectroscopy techniques in the time range from femtoseconds to seconds were applied to investigate the charge separation processes in complete dye-sensitized solar cells (DSC) made with iodide/iodine liquid electrolyte and indoline dye D149 interacting with TiO2 or ZnO nanoparticles. The aim of the studies was to explain the differences in the photocurrents of the cells (3-4 times higher for TiO2 than for ZnO ones). Electrochemical impedance spectroscopy and nanosecond flash photolysis studies revealed that the better performance of TiO2 samples is not due to the charge collection and dye regeneration processes. Femtosecond transient absorption results indicated that after first 100 ps the number of photoinduced electrons in the semiconductor is 3 times higher for TiO2 than for ZnO solar cells. Picosecond emission studies showed that the lifetime of the D149 excited state is about 3 times longer for ZnO than for TiO2 samples. Therefore, the results indicate that lower performance of ZnO solar cells is likely due to slower electron injection. The studies show how to correlate the laser spectroscopy methodology with global parameters of the solar cells and should help in better understanding of the behavior of alternative materials for porous electrodes for DSC and related devices.

Factors associated with prolonged time to treatment failure with fulvestrant 500 mg in patients with post-menopausal estrogen receptor-positive advanced breast cancer: a sub-group analysis of the JBCRG-C06 Safari study.

PubMed

Kawaguchi, Hidetoshi; Masuda, Norikazu; Nakayama, Takahiro; Aogi, Kenjiro; Anan, Keisei; Ito, Yoshinori; Ohtani, Shoichiro; Sato, Nobuaki; Saji, Shigehira; Takano, Toshimi; Tokunaga, Eriko; Nakamura, Seigo; Hasegawa, Yoshie; Hattori, Masaya; Fujisawa, Tomomi; Morita, Satoshi; Yamaguchi, Miki; Yamashita, Hiroko; Yamashita, Toshinari; Yamamoto, Yutaka; Yotsumoto, Daisuke; Toi, Masakazu; Ohno, Shinji

2018-01-01

The JBCRG-C06 Safari study showed that earlier fulvestrant 500 mg (F500) use, a longer time from diagnosis to F500 use, and no prior palliative chemotherapy were associated with significantly longer time to treatment failure (TTF) among Japanese patients with estrogen receptor-positive (ER+) advanced breast cancer (ABC). The objective of this sub-group analysis was to further examine data from the Safari study, focusing on ER + and human epidermal growth factor receptor-negative (HER2-) cases. The Safari study (UMIN000015168) was a retrospective, multi-center cohort study, conducted in 1,072 patients in Japan taking F500 for ER + ABC. The sub-analysis included only patients administered F500 as second-line or later therapy (n = 960). Of these, 828 patients were HER2-. Results Multivariate analysis showed that advanced age (≥65 years; p = .035), longer time (≥3 years) from ABC diagnosis to F500 use (p < .001), no prior chemotherapy (p < .001), and F500 treatment line (p < .001) were correlated with prolonged TTF (median = 5.39 months). In ER+/HER2- patients receiving F500 as a second-line or later therapy, treatment line, advanced age, no prior palliative chemotherapy use, and a longer period from ABC diagnosis to F500 use were associated with longer TTF.

Workflows and the Role of Images for Virtual 3d Reconstruction of no Longer Extant Historic Objects

NASA Astrophysics Data System (ADS)

Münster, S.

2013-07-01

3D reconstruction technologies have gained importance as tools for the research and visualization of no longer extant historic objects during the last decade. Within such reconstruction processes, visual media assumes several important roles: as the most important sources especially for a reconstruction of no longer extant objects, as a tool for communication and cooperation within the production process, as well as for a communication and visualization of results. While there are many discourses about theoretical issues of depiction as sources and as visualization outcomes of such projects, there is no systematic research about the importance of depiction during a 3D reconstruction process and based on empirical findings. Moreover, from a methodological perspective, it would be necessary to understand which role visual media plays during the production process and how it is affected by disciplinary boundaries and challenges specific to historic topics. Research includes an analysis of published work and case studies investigating reconstruction projects. This study uses methods taken from social sciences to gain a grounded view of how production processes would take place in practice and which functions and roles images would play within them. For the investigation of these topics, a content analysis of 452 conference proceedings and journal articles related to 3D reconstruction modeling in the field of humanities has been completed. Most of the projects described in those publications dealt with data acquisition and model building for existing objects. Only a small number of projects focused on structures that no longer or never existed physically. Especially that type of project seems to be interesting for a study of the importance of pictures as sources and as tools for interdisciplinary cooperation during the production process. In the course of the examination the authors of this paper applied a qualitative content analysis for a sample of 26 previously published project reports to depict strategies and types and three case studies of 3D reconstruction projects to evaluate evolutionary processes during such projects. The research showed that reconstructions of no longer existing historic structures are most commonly used for presentation or research purposes of large buildings or city models. Additionally, they are often realized by interdisciplinary workgroups using images as the most important source for reconstruction as far as important media for communication and quality control during the reconstruction process.

Using the self-select paradigm to delineate the nature of speech motor programming.

PubMed

Wright, David L; Robin, Don A; Rhee, Jooyhun; Vaculin, Amber; Jacks, Adam; Guenther, Frank H; Fox, Peter T

2009-06-01

The authors examined the involvement of 2 speech motor programming processes identified by S. T. Klapp (1995, 2003) during the articulation of utterances differing in syllable and sequence complexity. According to S. T. Klapp, 1 process, INT, resolves the demands of the programmed unit, whereas a second process, SEQ, oversees the serial order demands of longer sequences. A modified reaction time paradigm was used to assess INT and SEQ demands. Specifically, syllable complexity was dependent on syllable structure, whereas sequence complexity involved either repeated or unique syllabi within an utterance. INT execution was slowed when articulating single syllables in the form CCCV compared to simpler CV syllables. Planning unique syllables within a multisyllabic utterance rather than repetitions of the same syllable slowed INT but not SEQ. The INT speech motor programming process, important for mental syllabary access, is sensitive to changes in both syllable structure and the number of unique syllables in an utterance.

Influence of Surface Finishing on the Oxidation Behaviour of VPS MCrAlY Coatings

NASA Astrophysics Data System (ADS)

Fossati, Alessio; di Ferdinando, Martina; Bardi, Ugo; Scrivani, Andrea; Giolli, Carlo

2012-03-01

CoNiCrAlY coatings were produced by means of the vacuum plasma spraying (VPS) process onto CMSX-4 single crystal nickel superalloy disk substrates. As-sprayed samples were annealed at high temperatures in low vacuum. Three kinds of finishing processes were carried out, producing three types of samples: as-sprayed, mechanically smoothed by grinding, ground and PVD coated by using aluminum targets in an oxygen atmosphere. Samples were tested under isothermal conditions, in air, at 1000 °C, and up to 5000 h. Morphological, microstructural and compositional analyses were performed on the coated samples in order to assess the high temperature oxidation behavior provided by the three different surface finishing processes. Several differences were observed: grinding operations decrease the oxidation resistance, whereas the PVD process can increase the performances over longer time with respect of the as-sprayed samples.

Identity, Culture and Cosmopolitan Futures

ERIC Educational Resources Information Center

Rizvi, Fazal

2005-01-01

This paper examines the policy notion of multiculturalism, and suggests that it is no longer adequate for understanding contemporary forms of interculturality that span across the globe, and are deeply affected by the processes of cultural globalization. Cultural identities can no longer be assumed as static and nation-bound, and are created…

A framework for building real-time expert systems

NASA Technical Reports Server (NTRS)

Lee, S. Daniel

1991-01-01

The Space Station Freedom is an example of complex systems that require both traditional and artificial intelligence (AI) real-time methodologies. It was mandated that Ada should be used for all new software development projects. The station also requires distributed processing. Catastrophic failures on the station can cause the transmission system to malfunction for a long period of time, during which ground-based expert systems cannot provide any assistance to the crisis situation on the station. This is even more critical for other NASA projects that would have longer transmission delays (e.g., the lunar base, Mars missions, etc.). To address these issues, a distributed agent architecture (DAA) is proposed that can support a variety of paradigms based on both traditional real-time computing and AI. The proposed testbed for DAA is an autonomous power expert (APEX) which is a real-time monitoring and diagnosis expert system for the electrical power distribution system of the space station.

Coupled thermal/chemical/mechanical modeling of energetic materials in ALE3D

NASA Technical Reports Server (NTRS)

Nichols, A. L.; Couch, R.; Maltby, J. D.; McCallen, R. C.; Otero, I.

1996-01-01

We must improve our ability to model the response of energetic materials to thermal stimuli and the processes involved in the energetic response. We have developed and used a time step option to efficiently and accurately compute the hours that the energetic material can take to react. Since on these longer film scales, materials can be expected to have significant motion, it is even more important to provide high-order advection for all components, including the chemical species. We show an example cook-off problem to illustrate these capabilities.

Kinetics of formation of nanoparticles from first group metal carboxylates

NASA Astrophysics Data System (ADS)

Solov'ev, M. E.; Irzhak, T. F.; Irzhak, V. I.

2015-09-01

A kinetic model of the formation of metal nanoparticles via reduction of their carboxylates under conditions of clustering is proposed. It is found that the kinetics of the process is characterized by an induction period in carboxylate consumption and by almost linear growth of the average size of nanoparticles with conversion. It is shown that the maximum rate of nanoparticle formation grows along with the rate of ternary associate formation, the induction period becomes longer, and the particle size decreases. At the same time, it is characterized by a narrow size distribution.

Aging of nickel added to soils as predicted by soil pH and time.

PubMed

Ma, Yibing; Lombi, Enzo; McLaughlin, Mike J; Oliver, Ian W; Nolan, Annette L; Oorts, Koen; Smolders, Erik

2013-08-01

Although aging processes are important in risk assessment for metals in soils, the aging of Ni added to soils has not been studied in detail. In this study, after addition of water soluble Ni to soils, the changes over time in isotopic exchangeability, total concentrations and free Ni(2+) activity in soil pore water, were investigated in 16 European soils incubated outdoors for 18 months. The results showed that after Ni addition, concentrations of Ni in soil pore water and isotopic exchangeability of Ni in soils initially decreased rapidly. This phase was followed by further decreases in the parameters measured but these occurred at slower rates. Increasing soil pH increased the rate and extent of aging reactions. Semi-mechanistic models, based on Ni precipitation/nucleation on soil surfaces and micropore diffusion, were developed and calibrated. The initial fast processes, which were attributed to precipitation/nucleation, occurred over a short time (e.g. 1h), afterwards the slow processes were most likely controlled by micropore diffusion processes. The models were validated by comparing predicted and measured Ni aging in three additional, widely differing soils aged outdoors for periods up to 15 months in different conditions. These models could be used to scale ecotoxicological data generated in short-term studies to longer aging times. Copyright © 2013 Elsevier Ltd. All rights reserved.

Reconsidering Return-to-Play Times: A Broader Perspective on Concussion Recovery

PubMed Central

D’Lauro, Christopher; Johnson, Brian R.; McGinty, Gerald; Allred, C. Dain; Campbell, Darren E.; Jackson, Jonathan C.

2018-01-01

Background: Return-to-play protocols describe stepwise, graduated recoveries for safe return from concussion; however, studies that comprehensively track return-to-play time are expensive to administer and heavily sampled from elite male contact-sport athletes. Purpose: To retrospectively assess probable recovery time for collegiate patients to return to play after concussion, especially for understudied populations, such as women and nonelite athletes. Study Design: Cohort study; Level of evidence, 3. Methods: Medical staff at a military academy logged a total of 512 concussion medical records over 38 months. Of these, 414 records included complete return-to-play protocols with return-to-play time, sex, athletic status, cause, and other data. Results: Overall mean return to play was 29.4 days. Sex and athletic status both affected return-to-play time. Men showed significantly shorter return to play than women, taking 24.7 days (SEM, 1.5 days) versus 35.5 days (SEM, 2.7 days) (P < .001). Intercollegiate athletes also reported quicker return-to-play times than nonintercollegiate athletes: 25.4 days (SEM, 2.6 days) versus 34.7 days (SEM, 1.6 days) (P = .002). These variables did not significantly interact. Conclusion: Mean recovery time across all groups (29.4 days) showed considerably longer return to play than the most commonly cited concussion recovery time window (7-10 days) for collegiate athletes. Understudied groups, such as women and nonelite athletes, demonstrated notably longer recovery times. The diversity of this sample population was associated with longer return-to-play times; it is unclear how other population-specific factors may have contributed. These inclusive return-to-play windows may indicate longer recovery times outside the population of elite athletes. PMID:29568786

Ultrafast chemical interface scattering as an additional decay channel for nascent nonthermal electrons in small metal nanoparticles.

PubMed

Bauer, Christophe; Abid, Jean-Pierre; Fermin, David; Girault, Hubert H

2004-05-15

The use of 4.2 nm gold nanoparticles wrapped in an adsorbates shell and embedded in a TiO2 metal oxide matrix gives the opportunity to investigate ultrafast electron-electron scattering dynamics in combination with electronic surface phenomena via the surface plasmon lifetimes. These gold nanoparticles (NPs) exhibit a large nonclassical broadening of the surface plasmon band, which is attributed to a chemical interface damping. The acceleration of the loss of surface plasmon phase coherence indicates that the energy and the momentum of the collective electrons can be dissipated into electronic affinity levels of adsorbates. As a result of the preparation process, gold NPs are wrapped in a shell of sulfate compounds that gives rise to a large density of interfacial molecules confined between Au and TiO2, as revealed by Fourier-transform-infrared spectroscopy. A detailed analysis of the transient absorption spectra obtained by broadband femtosecond transient absorption spectroscopy allows separating electron-electron and electron-phonon interaction. Internal thermalization times (electron-electron scattering) are determined by probing the decay of nascent nonthermal electrons (NNEs) and the build-up of the Fermi-Dirac electron distribution, giving time constants of 540 to 760 fs at 0.42 and 0.34 eV from the Fermi level, respectively. Comparison with literature data reveals that lifetimes of NNEs measured for these small gold NPs are more than four times longer than for silver NPs with similar sizes. The surprisingly long internal thermalization time is attributed to an additional decay mechanism (besides the classical e-e scattering) for the energy loss of NNEs, identified as the ultrafast chemical interface scattering process. NNEs experience an inelastic resonant scattering process into unoccupied electronic states of adsorbates, that directly act as an efficient heat bath, via the excitation of molecular vibrational modes. The two-temperature model is no longer valid for this system because of (i) the temporal overlap between the internal and external thermalization process is very important; (ii) a part of the photonic energy is directly transferred toward the adsorbates (not among "cold" conduction band electrons). These findings have important consequence for femtochemistry on metal surfaces since they show that reactions can be initiated by nascent nonthermal electrons (as photoexcited, out of a Fermi-Dirac distribution) besides of the hot electron gas.

Flare forecasting at the Met Office Space Weather Operations Centre

NASA Astrophysics Data System (ADS)

Murray, S. A.; Bingham, S.; Sharpe, M.; Jackson, D. R.

2017-04-01

The Met Office Space Weather Operations Centre produces 24/7/365 space weather guidance, alerts, and forecasts to a wide range of government and commercial end-users across the United Kingdom. Solar flare forecasts are one of its products, which are issued multiple times a day in two forms: forecasts for each active region on the solar disk over the next 24 h and full-disk forecasts for the next 4 days. Here the forecasting process is described in detail, as well as first verification of archived forecasts using methods commonly used in operational weather prediction. Real-time verification available for operational flare forecasting use is also described. The influence of human forecasters is highlighted, with human-edited forecasts outperforming original model results and forecasting skill decreasing over longer forecast lead times.

Processing Coordinate Subject-Verb Agreement in L1 and L2 Greek

PubMed Central

Kaltsa, Maria; Tsimpli, Ianthi M.; Marinis, Theodoros; Stavrou, Melita

2016-01-01

The present study examines the processing of subject-verb (SV) number agreement with coordinate subjects in pre-verbal and post-verbal positions in Greek. Greek is a language with morphological number marked on nominal and verbal elements. Coordinate SV agreement, however, is special in Greek as it is sensitive to the coordinate subject's position: when pre-verbal, the verb is marked for plural while when post-verbal the verb can be in the singular. We conducted two experiments, an acceptability judgment task with adult monolinguals as a pre-study (Experiment 1) and a self-paced reading task as the main study (Experiment 2) in order to obtain acceptance as well as processing data. Forty adult monolingual speakers of Greek participated in Experiment 1 and a hundred and forty one in Experiment 2. Seventy one children participated in Experiment 2: 30 Albanian-Greek sequential bilingual children and 41 Greek monolingual children aged 10–12 years. The adult data in Experiment 1 establish the difference in acceptability between singular VPs in SV and VS constructions reaffirming our hypothesis. Meanwhile, the adult data in Experiment 2 show that plural verbs accelerate processing regardless of subject position. The child online data show that sequential bilingual children have longer reading times (RTs) compared to the age-matched monolingual control group. However, both child groups follow a similar processing pattern in both pre-verbal and post-verbal constructions showing longer RTs immediately after a singular verb when the subject was pre-verbal indicating a grammaticality effect. In the post-verbal coordinate subject sentences, both child groups showed longer RTs on the first subject following the plural verb due to the temporary number mismatch between the verb and the first subject. This effect was resolved in monolingual children but was still present at the end of the sentence for bilingual children indicating difficulties to reanalyze and integrate information. Taken together, these findings demonstrate that (a) 10–12 year-old sequential bilingual children are sensitive to number agreement in SV coordinate constructions parsing sentences in the same way as monolingual children even though their vocabulary abilities are lower than that of age-matched monolingual peers and (b) bilinguals are slower in processing overall. PMID:27242577

Atomic Layer Deposition for Coating of High Aspect Ratio TiO2 Nanotube Layers

PubMed Central

2016-01-01

We present an optimized approach for the deposition of Al2O3 (as a model secondary material) coating into high aspect ratio (≈180) anodic TiO2 nanotube layers using the atomic layer deposition (ALD) process. In order to study the influence of the diffusion of the Al2O3 precursors on the resulting coating thickness, ALD processes with different exposure times (i.e., 0.5, 2, 5, and 10 s) of the trimethylaluminum (TMA) precursor were performed. Uniform coating of the nanotube interiors was achieved with longer exposure times (5 and 10 s), as verified by detailed scanning electron microscopy analysis. Quartz crystal microbalance measurements were used to monitor the deposition process and its particular features due to the tube diameter gradient. Finally, theoretical calculations were performed to calculate the minimum precursor exposure time to attain uniform coating. Theoretical values on the diffusion regime matched with the experimental results and helped to obtain valuable information for further optimization of ALD coating processes. The presented approach provides a straightforward solution toward the development of many novel devices, based on a high surface area interface between TiO2 nanotubes and a secondary material (such as Al2O3). PMID:27643411

Identifying causes of laboratory turnaround time delay in the emergency department.

PubMed

Jalili, Mohammad; Shalileh, Keivan; Mojtahed, Ali; Mojtahed, Mohammad; Moradi-Lakeh, Maziar

2012-12-01

Laboratory turnaround time (TAT) is an important determinant of patient stay and quality of care. Our objective is to evaluate laboratory TAT in our emergency department (ED) and to generate a simple model for identifying the primary causes for delay. We measured TATs of hemoglobin, potassium, and prothrombin time tests requested in the ED of a tertiary-care, metropolitan hospital during a consecutive one-week period. The time of different steps (physician order, nurse registration, blood-draw, specimen dispatch from the ED, specimen arrival at the laboratory, and result availability) in the test turnaround process were recorded and the intervals between these steps (order processing, specimen collection, ED waiting, transit, and within-laboratory time) and total TAT were calculated. Median TATs for hemoglobin and potassium were compared with those of the 1990 Q-Probes Study (25 min for hemoglobin and 36 min for potassium) and its recommended goals (45 min for 90% of tests). Intervals were compared according to the proportion of TAT they comprised. Median TATs (170 min for 132 hemoglobin tests, 225 min for 172 potassium tests, and 195.5 min for 128 prothrombin tests) were drastically longer than Q-Probes reported and recommended TATs. The longest intervals were ED waiting time and order processing.  Laboratory TAT varies among institutions, and data are sparse in developing countries. In our ED, actions to reduce ED waiting time and order processing are top priorities. We recommend utilization of this model by other institutions in settings with limited resources to identify their own priorities for reducing laboratory TAT.

Local and Global Auditory Processing: Behavioral and ERP Evidence

PubMed Central

Sanders, Lisa D.; Poeppel, David

2007-01-01

Differential processing of local and global visual features is well established. Global precedence effects, differences in event-related potentials (ERPs) elicited when attention is focused on local versus global levels, and hemispheric specialization for local and global features all indicate that relative scale of detail is an important distinction in visual processing. Observing analogous differential processing of local and global auditory information would suggest that scale of detail is a general organizational principle of the brain. However, to date the research on auditory local and global processing has primarily focused on music perception or on the perceptual analysis of relatively higher and lower frequencies. The study described here suggests that temporal aspects of auditory stimuli better capture the local-global distinction. By combining short (40 ms) frequency modulated tones in series to create global auditory patterns (500 ms), we independently varied whether pitch increased or decreased over short time spans (local) and longer time spans (global). Accuracy and reaction time measures revealed better performance for global judgments and asymmetric interference that were modulated by amount of pitch change. ERPs recorded while participants listened to identical sounds and indicated the direction of pitch change at the local or global levels provided evidence for differential processing similar to that found in ERP studies employing hierarchical visual stimuli. ERP measures failed to provide evidence for lateralization of local and global auditory perception, but differences in distributions suggest preferential processing in more ventral and dorsal areas respectively. PMID:17113115

Optimizing Fire Department Operations Through Work Schedule Analysis, Alternative Staffing, and Nonproductive Time Reduction

DTIC Science & Technology

2014-09-01

hour work shift. A longer shift offers more time off between shifts, which can improve the employee’s family life , and personal emotional stress . On...Enhancing Work / Life Balance ,” Conn.L.Rev. 42 (2010): 1081–1527. 19 Nicole Jansen et al., “Need for Recovery from Work : Evaluating Short-Term Effects...24-hour work shift. A longer shift offers more time off between shifts that can improve the employee’s family life and personal emotional stress

Reminder effects: the molecular cascade following a reminder in young chicks does not recapitulate that following training on a passive avoidance task.

PubMed

Salinska, Elzbieta; Bourne, Rachel C; Rose, Steven P R

2004-06-01

Memory traces, once established, are no longer sensitive to disruption by metabolic inhibitors. However, memories reactivated by reminder are once again vulnerable, in a time-dependent manner, to amnestic treatment. To determine whether the metabolic events following a reminder recapitulate those following initial training we examined the temporal dynamics of amnesia induced by the protein synthesis inhibitor anisomycin and the glycosylation inhibitor 2-deoxygalactose. The effects of both were transient and dependent on time of reminder post-training and time of injection relative to reminder, and differed from those following initial training. 2-[(14)C]-deoxyglucose uptake increased in two brain regions, the intermediate medial hyperstriatum ventrale (IMHV) and lobus parolfactorius (LPO) following reminder as it did following training, but the increase was bilateral rather than confined to the left hemisphere and was more marked in LPO than IMHV. C-fos expression after reminder was increased only in the LPO, the chick brain region associated with a late phase of memory processing and recall. Thus although, like initial consolidation, memory processing after reminder is sensitive to inhibitors of protein synthesis and glycosylation, the temporal and pharmacological dynamics indicate differences between these two processes.

Persistent random walk of cells involving anomalous effects and random death

NASA Astrophysics Data System (ADS)

Fedotov, Sergei; Tan, Abby; Zubarev, Andrey

2015-04-01

The purpose of this paper is to implement a random death process into a persistent random walk model which produces sub-ballistic superdiffusion (Lévy walk). We develop a stochastic two-velocity jump model of cell motility for which the switching rate depends upon the time which the cell has spent moving in one direction. It is assumed that the switching rate is a decreasing function of residence (running) time. This assumption leads to the power law for the velocity switching time distribution. This describes the anomalous persistence of cell motility: the longer the cell moves in one direction, the smaller the switching probability to another direction becomes. We derive master equations for the cell densities with the generalized switching terms involving the tempered fractional material derivatives. We show that the random death of cells has an important implication for the transport process through tempering of the superdiffusive process. In the long-time limit we write stationary master equations in terms of exponentially truncated fractional derivatives in which the rate of death plays the role of tempering of a Lévy jump distribution. We find the upper and lower bounds for the stationary profiles corresponding to the ballistic transport and diffusion with the death-rate-dependent diffusion coefficient. Monte Carlo simulations confirm these bounds.

Video Laryngoscopic Techniques Associated with Intubation Success in a Helicopter Emergency Medical Service System.

PubMed

Naito, Hiromichi; Guyette, Francis X; Martin-Gill, Christian; Callaway, Clifton W

2016-01-01

Video laryngoscopy (VL) is a technical adjunct to facilitate endotracheal intubation (ETI). VL also provides objective data for training and quality improvement, allowing evaluation of the technique and airway conditions during ETI. Previous studies of factors associated with ETI success or failure are limited by insufficient nomenclature, individual recall bias and self-report. We tested whether the covariates in prehospital VL recorded data were associated with ETI success. We also measured association between time and clinical variables. Retrospective review was conducted in a non-physician staffed helicopter emergency medical service system. ETI was typically performed using sedation and neuromuscular-blockade under protocolized orders. We obtained process and outcome variables from digitally recorded VL data. Patient characteristics data were also obtained from the emergency medical service record and linked to the VL recorded data. The primary outcome was to identify VL covariates associated with successful ETI attempts. Among 304 VL recorded ETI attempts in 268 patients, ETI succeeded for 244 attempts and failed for 60 attempts (first-pass success rate, 82% and overall success rate, 94%). Laryngoscope blade tip usually moved from a shallow position in the oropharynx to the vallecula. In the multivariable logistic regression analysis, attempt time (p = 0.02; odds ratio [OR] 0.99), Cormack-Lehane view (p < 0.001; OR 0.23), bodily fluids obstructing the view (p = 0.01; OR 0.29), and VL equipment failure (p < 0.001; OR 0.14) were negatively associated with successful attempts. Bodily fluids obstructing the view (p < 0.001; hazard ratio [HR] 0.51), VL equipment failure (p = 0.003; HR 0.42), shallow placement of blade tip within 4 seconds (p < 0.001; HR 0.40), number of forward movements (p < 0.001; HR 0.84), trauma (p = 0.04; HR 0.65), and neurological diagnosis (p = 0.04; HR 0.60) were associated with longer ETI attempt time. Bodily fluids obstructing the view, equipment problems, higher Cormack-Lehane view, and longer ETI attempt time were negatively associated with successful ETI attempts. Initially shallow blade tip position may associate with longer ETI time. VL is useful for measuring and describing multiple factors of ETI and can provide valuable data.

An ion mobility-mass spectrometry investigation of monocyte chemoattractant protein-1

NASA Astrophysics Data System (ADS)

Schenauer, Matthew R.; Leary, Julie A.

2009-10-01

In the present article we describe the gas-phase dissociation behavior of the dimeric form of monocyte chemoattractant protein-1 (MCP-1) using quadrupole-traveling wave ion mobility spectrometry-time of flight mass spectrometry (q-TWIMS-TOF MS) (Waters Synapt(TM)). Through investigation of the 9+ charge state of the dimer, we were able to monitor dissociation product ion (monomer) formation as a function of activation energy. Using ion mobility, we were able to observe precursor ion structural changes occurring throughout the activation process. Arrival time distributions (ATDs) for the 5+ monomeric MCP-1 product ions, derived from the gas-phase dissociation of the 9+ dimer, were then compared with ATDs obtained for the 5+ MCP-1 monomer isolated directly from solution. The results show that the dissociated monomer is as compact as the monomer arising from solution, regardless of the trap collision energy (CE) used in the dissociation. The solution-derived monomer, when collisionally activated, also resists significant unfolding within measure. Finally, we compared the collisional activation data for the MCP-1 dimer with an MCP-1 dimer non-covalently bound to a single molecule of the semi-synthetic glycosaminoglycan (GAG) analog Arixtra(TM); the latter a therapeutic anti-thrombin III-activating pentasaccharide. We observed that while dimeric MCP-1 dissociated at relatively low trap CEs, the Arixtra-bound dimer required much higher energies, which also induced covalent bond cleavage in the bound Arixtra molecule. Both the free and Arixtra-bound dimers became less compact and exhibited longer arrival times with increasing trap CEs, albeit the Arixtra-bound complex at slightly higher energies. That both dimers shifted to longer arrival times with increasing activation energy, while the dissociated MCP-1 monomers remained compact, suggests that the longer arrival times of the Arixtra-free and Arixtra-bound dimers may represent a partial breach of non-covalent interactions between the associated MCP-1 monomers, rather than extensive unfolding of individual subunits. The fact that Arixtra preferentially binds MCP-1 dimers and prevents dimer dissociation at comparable activation energies to the Arixtra-free dimer, may suggest that the drug interacts across the two monomers, thereby inhibiting their dissociation.

Time for actions in lucid dreams: effects of task modality, length, and complexity

PubMed Central

Erlacher, Daniel; Schädlich, Melanie; Stumbrys, Tadas; Schredl, Michael

2014-01-01

The relationship between time in dreams and real time has intrigued scientists for centuries. The question if actions in dreams take the same time as in wakefulness can be tested by using lucid dreams where the dreamer is able to mark time intervals with prearranged eye movements that can be objectively identified in EOG recordings. Previous research showed an equivalence of time for counting in lucid dreams and in wakefulness (LaBerge, 1985; Erlacher and Schredl, 2004), but Erlacher and Schredl (2004) found that performing squats required about 40% more time in lucid dreams than in the waking state. To find out if the task modality, the task length, or the task complexity results in prolonged times in lucid dreams, an experiment with three different conditions was conducted. In the first condition, five proficient lucid dreamers spent one to three non-consecutive nights in the sleep laboratory. Participants counted to 10, 20, and 30 in wakefulness and in their lucid dreams. Lucidity and task intervals were time stamped with left-right-left-right eye movements. The same procedure was used for the second condition where eight lucid dreamers had to walk 10, 20, or 30 steps. In the third condition, eight lucid dreamers performed a gymnastics routine, which in the waking state lasted the same time as walking 10 steps. Again, we found that performing a motor task in a lucid dream requires more time than in wakefulness. Longer durations in the dream state were present for all three tasks, but significant differences were found only for the tasks with motor activity (walking and gymnastics). However, no difference was found for relative times (no disproportional time effects) and a more complex motor task did not result in more prolonged times. Longer durations in lucid dreams might be related to the lack of muscular feedback or slower neural processing during REM sleep. Future studies should explore factors that might be associated with prolonged durations. PMID:24474942

Time for actions in lucid dreams: effects of task modality, length, and complexity.

PubMed

Erlacher, Daniel; Schädlich, Melanie; Stumbrys, Tadas; Schredl, Michael

2013-01-01

The relationship between time in dreams and real time has intrigued scientists for centuries. The question if actions in dreams take the same time as in wakefulness can be tested by using lucid dreams where the dreamer is able to mark time intervals with prearranged eye movements that can be objectively identified in EOG recordings. Previous research showed an equivalence of time for counting in lucid dreams and in wakefulness (LaBerge, 1985; Erlacher and Schredl, 2004), but Erlacher and Schredl (2004) found that performing squats required about 40% more time in lucid dreams than in the waking state. To find out if the task modality, the task length, or the task complexity results in prolonged times in lucid dreams, an experiment with three different conditions was conducted. In the first condition, five proficient lucid dreamers spent one to three non-consecutive nights in the sleep laboratory. Participants counted to 10, 20, and 30 in wakefulness and in their lucid dreams. Lucidity and task intervals were time stamped with left-right-left-right eye movements. The same procedure was used for the second condition where eight lucid dreamers had to walk 10, 20, or 30 steps. In the third condition, eight lucid dreamers performed a gymnastics routine, which in the waking state lasted the same time as walking 10 steps. Again, we found that performing a motor task in a lucid dream requires more time than in wakefulness. Longer durations in the dream state were present for all three tasks, but significant differences were found only for the tasks with motor activity (walking and gymnastics). However, no difference was found for relative times (no disproportional time effects) and a more complex motor task did not result in more prolonged times. Longer durations in lucid dreams might be related to the lack of muscular feedback or slower neural processing during REM sleep. Future studies should explore factors that might be associated with prolonged durations.

Developmental changes in shortening of pro-saccade reaction time while maintaining neck flexion position.

PubMed

Kunita, Kenji; Fujiwara, Katsuo; Kiyota, Naoe; Yaguchi, Chie; Kiyota, Takeo

2018-01-10

We investigated developmental changes in shortening of pro-saccade reaction time while maintaining neck flexion. Subjects comprised 135 children (3-14 years) and 29 young adults (19-23 years). Children were divided into six groups in 2-year age strata. Pro-saccade reaction tasks for 30 s were performed in neck rest and flexion positions. Reaction times under each position were averaged in every 10-s period. Under neck rest position, reaction time in the 0-10 s period was significantly longer in the 3- to 4-year-old group than in the 5- to 6-year-old group and above. No significant age effect was found for reaction time in the 0-10 s period in the 5- to 6-year-old group and above. Although a significant effect of neck flexion was not observed until the 9- to 10-year-old group, significant shortening of reaction time with neck flexion was found in the 11- to 12-year-old group and above. Furthermore, this shortening was maintained until the first 20-s period in the 11- to 12-year-old group and during the entire 30 s in the 13- to 14-year-old and above. These results suggest that brain activation with the maintenance of neck flexion, related to shortening of the pro-saccade reaction time, was found from a later age of approximately 11 years and above, compared with the age at which information-processing function in the pro-saccade was enhanced. In addition, brain activation with the maintenance of neck flexion was sustained longer with age.

Assessment of Real-Time Time-Dependent Density Functional Theory (RT-TDDFT) in Radiation Chemistry: Ionized Water Dimer.

PubMed

Chalabala, Jan; Uhlig, Frank; Slavíček, Petr

2018-03-29

Ionization in the condensed phase and molecular clusters leads to a complicated chain of processes with coupled electron-nuclear dynamics. It is difficult to describe such dynamics with conventional nonadiabatic molecular dynamics schemes since the number of states swiftly increases as the molecular system grows. It is therefore attractive to use a direct electron and nuclear propagation such as the real-time time-dependent density functional theory (RT-TDDFT). Here we report a RT-TDDFT benchmark study on simulations of singly and doubly ionized states of a water monomer and dimer as a prototype for more complex processes in a condensed phase. We employed the RT-TDDFT based Ehrenfest molecular dynamics with a generalized gradient approximate (GGA) functional and compared it with wave-function-based surface hopping (SH) simulations. We found that the initial dynamics of a singly HOMO ionized water dimer is similar for both the RT-TDDFT/GGA and the SH simulations but leads to completely different reaction channels on a longer time scale. This failure is attributed to the self-interaction error in the GGA functionals and it can be avoided by using hybrid functionals with large fraction of exact exchange (represented here by the BHandHLYP functional). The simulations of doubly ionized states are reasonably described already at the GGA level. This suggests that the RT-TDDFT/GGA method could describe processes following the autoionization processes such as Auger emission, while its applicability to more complex processes such as intermolecular Coulombic decay remains limited.

RF atmospheric plasma jet surface treatment of paper

NASA Astrophysics Data System (ADS)

Pawlat, Joanna; Terebun, Piotr; Kwiatkowski, Michał; Diatczyk, Jaroslaw

2016-09-01

A radio frequency RF atmospheric pressure plasma jet was used to enhance the wettability of cellulose-based paper of 90 g m-2 and 160 g m-2 grammage as a perspective platform for antibiotic sensitivity tests. Helium and argon were the carrier gases for oxygen and nitrogen; pure water and rapeseed oil were used for goniometric tests. The influence of the flow rate and gas type, the power of the discharge, and distance from the nozzle was examined. The surface structure was observed using an optical microscope. Attenuated total reflection Fourier transform infrared (ATR-FTIR) spectra were investigated in order to determine whether cellulose degradation processes occurred. The RF plasma jet allowed us to decrease the surface contact angle without drastic changes in other features of the tested material. Experiments confirmed the significant influence of the distance between the treated sample and reactor nozzle, especially for treatment times longer than 15 s due to the greater concentration of reactive species at the surface of the sample, which decreases with distance—and their accumulation effect with time. The increase of discharge power plays an important role in decreasing the surface contact angle for times longer than 10 s. Higher power had a positive effect on the amount of generated active particles and facilitated the ignition of discharge. However, a too high value can cause a rise in temperature of the material and heat-caused damage.

Factors affecting pregnancy length and phases of parturition in Martina Franca jennies.

PubMed

Carluccio, Augusto; Gloria, Alessia; Veronesi, Maria Cristina; De Amicis, Ippolito; Noto, Federico; Contri, Alberto

2015-09-01

The knowledge of normal pregnancy length, duration of parturition stages, and neonatal early adaptation is mandatory for a rationale management of birth, especially in monotocous species with long gestations. This study reports data obtained from a large number of Martina Franca jennies with normal healthy pregnancies and spontaneous eutocic delivery of a mature, healthy, and viable donkey foal. Pregnancy lasts, on average, 371 days, and only the fetal gender significantly determines pregnancy length, with longer gestations observed in jennies bearing male fetuses. Other factors such as the year of foaling, month of ovulation, month of parturition, birth weight of the foal, and age of the jenny did not influence pregnancy length. The first stage of foaling lasted on average 65 minutes, the second stage 19 minutes, and the third stage 58 minutes. The umbilical cord ruptured on average within 16 minutes after birth; the foal stood up in 61 minutes and suckled the colostrum for the first time within 10 minutes after birth and again after 143 minutes of birth; meconium passage occurred, on average, 86 minutes after birth. Although times reported for the process of foaling are similar to data reported for the horse, the times for early neonatal donkey foal adaptation are longer as compared to the horse foal. Copyright © 2015 Elsevier Inc. All rights reserved.

Computer model to simulate testing at the National Transonic Facility

NASA Technical Reports Server (NTRS)

Mineck, Raymond E.; Owens, Lewis R., Jr.; Wahls, Richard A.; Hannon, Judith A.

1995-01-01

A computer model has been developed to simulate the processes involved in the operation of the National Transonic Facility (NTF), a large cryogenic wind tunnel at the Langley Research Center. The simulation was verified by comparing the simulated results with previously acquired data from three experimental wind tunnel test programs in the NTF. The comparisons suggest that the computer model simulates reasonably well the processes that determine the liquid nitrogen (LN2) consumption, electrical consumption, fan-on time, and the test time required to complete a test plan at the NTF. From these limited comparisons, it appears that the results from the simulation model are generally within about 10 percent of the actual NTF test results. The use of actual data acquisition times in the simulation produced better estimates of the LN2 usage, as expected. Additional comparisons are needed to refine the model constants. The model will typically produce optimistic results since the times and rates included in the model are typically the optimum values. Any deviation from the optimum values will lead to longer times or increased LN2 and electrical consumption for the proposed test plan. Computer code operating instructions and listings of sample input and output files have been included.

EAO Supplement Working Group 4 - EAO CC 2015 Short implants versus sinus lifting with longer implants to restore the posterior maxilla: a systematic review.

PubMed

Thoma, D S; Zeltner, M; Hüsler, J; Hämmerle, C H F; Jung, R E

2015-09-01

To compare short implants in the posterior maxilla to longer implants placed after or simultaneously with sinus floor elevation procedures. The focused question was as follows: Are short implants superior to longer implants in the augmented sinus in terms of survival and complication rates of implants and reconstructions, patient-reported outcome measures (PROMs) and costs? A MEDLINE search (1990-2014) was performed for randomized controlled clinical studies comparing short implants (≤8 mm) to longer implants (>8 mm) in augmented sinus. The search was complimented by an additional hand search of the selected papers and reviews published between 2011 and 2014. Eligible studies were selected based on the inclusion criteria, and quality assessments were conducted. Descriptive statistics were applied for a number of outcome measures. Survival rates of dental implants were pooled simply in case of comparable studies. Eight randomized controlled clinical trials (RCTs) comparing short implants versus longer implants in the augmented sinus derived from an initial search count of 851 titles were selected and data extracted. In general, all studies were well conducted with a low risk of bias for the majority of the analyzed parameters. Based on the pooled analyses of longer follow-ups (5 studies, 16-18 months), the survival rate of longer implants amounted to 99.5% (95% CI: 97.6-99.98%) and for shorter implants to 99.0% (95% CI: 96.4-99.8%). For shorter follow-ups (3 studies, 8-9 months), the survival rates of longer implants are 100% (95% CI: 97.1-100%) and for shorter implants 98.2% (95% CI: 93.9-99.7%). Complications were predominantly of biological origin, mainly occurred intraoperatively as membrane perforations, and were almost three times as higher for longer implant in the augmented sinus compared to shorter implants. PROMs, morbidity, surgical time and costs were generally in favor of shorter dental implants. All studies were performed by surgeons in specialized clinical settings. The outcomes of the survey analyses demonstrated predictably high implant survival rates for short implants and longer implants placed in augmented sinus and their respective reconstructions. Given the higher number of biological complications, increased morbidity, costs and surgical time of longer dental implants in the augmented sinus, shorter dental implants may represent the preferred treatment alternative. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Initial orienting towards sexually relevant stimuli: preliminary evidence from eye movement measures.

PubMed

Fromberger, Peter; Jordan, Kirsten; von Herder, Jakob; Steinkrauss, Henrike; Nemetschek, Rebekka; Stolpmann, Georg; Müller, Jürgen Leo

2012-08-01

It has been proposed that sexual stimuli will be processed in a comparable manner to other evolutionarily meaningful stimuli (such as spiders or snakes) and therefore elicit an attentional bias and more attentional engagement (Spiering and Everaerd, In E. Janssen (Ed.), The psychophysiology of sex (pp. 166-183). Bloomington: Indiana University Press, 2007). To investigate early and late attentional processes while looking at sexual stimuli, heterosexual men (n = 12) viewed pairs of sexually preferred (images of women) and sexually non-preferred images (images of girls, boys or men), while eye movements were measured. Early attentional processing (initial orienting) was assessed by the number of first fixations and late attentional processing (maintenance of attention) was assessed by relative fixation time. Results showed that relative fixation time was significantly longer for sexually preferred stimuli than for sexually non-preferred stimuli. Furthermore, the first fixation was more often directed towards the preferred sexual stimulus, when simultaneously presented with a non-sexually preferred stimulus. Thus, the current study showed for the first time an attentional bias to sexually relevant stimuli when presented simultaneously with sexually irrelevant pictures. This finding, along with the discovery that heterosexual men maintained their attention to sexually relevant stimuli, highlights the importance of investigating early and late attentional processes while viewing sexual stimuli. Furthermore, the current study showed that sexually relevant stimuli are favored by the human attentional system.

The ecology of eating: smaller portion sizes in France Than in the United States help explain the French paradox.

PubMed

Rozin, Paul; Kabnick, Kimberly; Pete, Erin; Fischler, Claude; Shields, Christy

2003-09-01

Part of the "French paradox" can be explained by the fact that the French eat less than Americans. We document that French portion sizes are smaller in comparable restaurants, in the sizes of individual portions of foods (but not other items) in supermarkets, in portions specified in cookbooks, and in the prominence of "all you can eat" restaurants in dining guides. We also present data, from observations at McDonald's, that the French take longer to eat than Americans. Our results suggest that in the domain of eating, and more generally, more attention should be paid to ecological factors, even though their mechanism of operation is transparent, and hence less revealing of fundamental psychological processes. Ironically, although the French eat less than Americans, they seem to eat for a longer period of time, and hence have more food experience. The French can have their cake and eat it as well.

Is seeing believing? Expectant parents’ outlooks on coparenting and later coparenting solidarity

PubMed Central

McHale, James P.; Rotman, Tamir

2007-01-01

This study examined short- and longer-term sequelae of parents’ prenatal expectations of their future family process, and traced subsequent stability in coparenting solidarity from infancy through the toddler years. 110 couples expecting a first child participated in prenatal assessments of coparenting expectations and differences, and in 3 month post-partum evaluations. 45 couples completed subsequent assessments at 12 and 30 months. At each time point multi-method evaluations of coparental adjustment were obtained. Men’s and women’s expectancies during the pregnancy and the degree of difference between their self-reported beliefs about parenting predicted post-baby coparental adjustment, with latent class analyses suggesting aftereffects of prenatal expectancies up through 30 months for some couples. Coparental solidarity was also stable from 3 to 12 and from 12 to 30 months. Data indicate that the lens parents bring to bear on their emerging family system is not immaterial, and that early-emerging coparenting dynamics portend longer term coparenting adjustment. PMID:17292781

Dynamic of particle-laden liquid sheet

NASA Astrophysics Data System (ADS)

Sauret, Alban; Jop, Pierre; Troger, Anthony

2016-11-01

Many industrial processes, such as surface coating or liquid transport in tubes, involve liquid sheets or thin liquid films of suspensions. In these situations, the thickness of the liquid film becomes comparable to the particle size, which leads to unexpected dynamics. In addition, the classical constitutive rheological law cannot be applied as the continuum approximation is no longer valid. Here, we consider experimentally a transient free liquid sheet that expands radially. We characterize the influence of the particles on the shape of the liquid film as a function of time and the atomization process. We highlight that the presence of particles modifies the thickness and the stability of the liquid sheet. Our study suggests that the influence of particles through capillary effects can modify significantly the dynamics of processes that involve suspensions and particles confined in liquid films.

Association of Physical Performance and Pain With Fear of Falling Among Community—Dwelling Japanese Women Aged 65 Years and Older

PubMed Central

Tomita, Yoshihito; Arima, Kazuhiko; Kanagae, Mitsuo; Okabe, Takuhiro; Mizukami, Satoshi; Nishimura, Takayuki; Abe, Yasuyo; Goto, Hisashi; Horiguchi, Itsuko; Aoyagi, Kiyoshi

2015-01-01

Abstract Our aim was to explore the association of physical performance and pain with fear of falling among community-dwelling Japanese women. The subjects were 278 women aged 65 years and over. We collected information on fear of falling, painful joints, comorbidities, falls in the previous year, and cataracts. Walking time (distance of 6 m), chair stand time (5 times), grip strength, the timed up and go test (TUG), and functional reach were measured. The prevalence of fear of falling was 36.3%, and it increased with age, but it was not significant (P = 0.081). Multivariate logistic regression analysis showed that poor physical performance (longer walking time, longer chair stand time, weaker grip strength, and longer TUG) and pain (low back, and upper and lower extremity pain) were significantly associated with fear of falling after adjusting for age, body mass index, comorbidities, falls in the previous year, and cataracts. Maintaining physical functioning and managing pain may be important for elderly women with fear of falling. PMID:26334906

Association of Physical Performance and Pain With Fear of Falling Among Community-Dwelling Japanese Women Aged 65 Years and Older.

PubMed

Tomita, Yoshihito; Arima, Kazuhiko; Kanagae, Mitsuo; Okabe, Takuhiro; Mizukami, Satoshi; Nishimura, Takayuki; Abe, Yasuyo; Goto, Hisashi; Horiguchi, Itsuko; Aoyagi, Kiyoshi

2015-09-01

Our aim was to explore the association of physical performance and pain with fear of falling among community-dwelling Japanese women.The subjects were 278 women aged 65 years and over. We collected information on fear of falling, painful joints, comorbidities, falls in the previous year, and cataracts. Walking time (distance of 6 m), chair stand time (5 times), grip strength, the timed up and go test (TUG), and functional reach were measured.The prevalence of fear of falling was 36.3%, and it increased with age, but it was not significant (P = 0.081). Multivariate logistic regression analysis showed that poor physical performance (longer walking time, longer chair stand time, weaker grip strength, and longer TUG) and pain (low back, and upper and lower extremity pain) were significantly associated with fear of falling after adjusting for age, body mass index, comorbidities, falls in the previous year, and cataracts.Maintaining physical functioning and managing pain may be important for elderly women with fear of falling.

Characterization and Modeling of Settling, Consolidation, and Suspension to Optimize Sediment Retention of Sediment Diversions for Coastal Restoration

NASA Astrophysics Data System (ADS)

Sha, X.; Xu, K.; Bentley, S. J.; Robichaux, P.

2016-02-01

Although many studies of sediment diversions have been conducted on the Mississippi Delta, relatively less attention has been paid to understanding sediment retention and basic cohesive sedimentation processes in receiving basins. Our research evaluates long-term (up to six months) sedimentation processes through various laboratory experiments, especially cohesive sediment settling, consolidation and resuspension and their impacts on sediment retention. Bulk sediment samples were collected from West Bay, near Head of Passes of the Mississippi Delta, and the Big Mar basin that receive water and sediment from the Caernarvon Diversion in the upper Breton Sound region of Louisiana, USA. A-230-cm tall settling column with nine sampling ports at 15 cm intervals was used to measure the consolidation for four initial sediment concentrations (10-120 kg m-3) with two salinities (1 ppt & 5 ppt). Samples of sediment slurry were taken from every port at different time intervals up to 15 days or longer (higher concentration needs longer time to consolidate) to record concentrations gravimetrically. A 200 cm long tube was connected to a 50 cm long core chamber to accumulate at least a 10 cm thick sediment column for erosion tests. A dual-core Gust Erosion Microcosm System was employed to measure time-series (0.5, 1, 2, 3, 4, 5, 6 months) erodibility at seven shear stress regimes (0.01-0.60 Pa). Our preliminary results show a significant decrease of erodibility with time and high concentration (120g/L). Salinity impacted on sediment behavior in consolidation experiments. Our study reveals that more enclosed receiving basins, intermittent openings of diversions, or reduced shear stress due to man-made structure all can potentially reduce cohesive sediment erosion in coastal Louisiana. Further results will be analyzed to determine the model constants. Consolidating rates and corresponding erosional changes will be determined to optimize sediment retention in coastal protection.

Multiscale magmatic cyclicity, duration of pluton construction, and the paradoxical relationship between tectonism and plutonism in continental arcs

NASA Astrophysics Data System (ADS)

de Saint Blanquat, Michel; Horsman, Eric; Habert, Guillaume; Morgan, Sven; Vanderhaeghe, Olivier; Law, Richard; Tikoff, Basil

2011-03-01

The close relationship between crustal magmatism, an expression of heat dissipation, and tectonics, an expression of stress dissipation, leads to the question of their mutual relationships. Indeed, the low viscosity of magmas and the large viscosity contrast between magmas and surrounding rocks favor strain localization in magmas, and then possible "magmatic" initiation of structures at a wide range of scales. However, new data about 3-d pluton shape and duration of pluton construction perturb this simple geological image, and indicate some independence between magmatism and tectonics. In some cases we observe a direct genetic link and strong arguments for physical interactions between magmas and tectonics. In other cases, we observe an absence of these interactions and it is unclear how magma transfer and emplacement are related to lithospheric-plate dynamics. A simple explanation of this complexity follows directly from the pulsed, incremental assembly of plutons and its spatial and temporal characteristics. The size of each pluton is related to a magmatic pulsation at a particular time scale, and each of these coupled time/space scales is related to a specific process: in small plutons, we can observe the incremental process, the building block of plutons; in larger plutons, the incremental process is lost, and the pulsation, which consists of a cycle of injections at different timescales, must be related to the composition and thermal regime of the source region, itself driving magmatic processes (melting, segregation, and transfer) that interact with tectonic boundary conditions. The dynamics of pulsed magmatism observed in plutonic systems is then a proxy for deep lithospheric and magmatic processes. From our data and a review of published work, we find a positive corelation between volume and duration of pluton construction. The larger a pluton, the longer its construction time. Large/fast or small/slow plutons have not been identified to date. One consequence of this observation is that plutonic magmatic fluxes seem to be comparable from one geodynamic setting to another and also over various geologic time spans. A second consequence of this correlation is that small plutons, which are constructed in a geologically short length of time, commonly record little about tectonic conditions, and result only from the interference between magma dynamics and the local geologic setting. The fast rate of magma transfer in the crust (on the order of cm/s) relative to tectonic rates (on the order of cm/yr) explain why the incremental process of pluton construction is independent of - but not insensitive to - the tectonic setting. However, in large plutonic bodies, which correspond to longer duration magmatic events, regional deformation has time to interact with the growing pluton and can be recorded within the pluton-wall rock structure. Magma transfer operates at a very short timescale (comparable to volcanic timescales), which can be sustained over variable periods, depending on the fertility of the magma source region and its ability to feed the system. The fast operation of magmatic processes relative to crustal tectonic processes ensures that the former control the system from below.

Complementary fMRI and EEG evidence for more efficient neural processing of rhythmic vs. unpredictably timed sounds

PubMed Central

van Atteveldt, Nienke; Musacchia, Gabriella; Zion-Golumbic, Elana; Sehatpour, Pejman; Javitt, Daniel C.; Schroeder, Charles

2015-01-01

The brain’s fascinating ability to adapt its internal neural dynamics to the temporal structure of the sensory environment is becoming increasingly clear. It is thought to be metabolically beneficial to align ongoing oscillatory activity to the relevant inputs in a predictable stream, so that they will enter at optimal processing phases of the spontaneously occurring rhythmic excitability fluctuations. However, some contexts have a more predictable temporal structure than others. Here, we tested the hypothesis that the processing of rhythmic sounds is more efficient than the processing of irregularly timed sounds. To do this, we simultaneously measured functional magnetic resonance imaging (fMRI) and electro-encephalograms (EEG) while participants detected oddball target sounds in alternating blocks of rhythmic (e.g., with equal inter-stimulus intervals) or random (e.g., with randomly varied inter-stimulus intervals) tone sequences. Behaviorally, participants detected target sounds faster and more accurately when embedded in rhythmic streams. The fMRI response in the auditory cortex was stronger during random compared to random tone sequence processing. Simultaneously recorded N1 responses showed larger peak amplitudes and longer latencies for tones in the random (vs. the rhythmic) streams. These results reveal complementary evidence for more efficient neural and perceptual processing during temporally predictable sensory contexts. PMID:26579044

Development of Sensors for Aerospace Applications

NASA Technical Reports Server (NTRS)

Medelius, Pedro

2005-01-01

Advances in technology have led to the availability of smaller and more accurate sensors. Computer power to process large amounts of data is no longer the prevailing issue; thus multiple and redundant sensors can be used to obtain more accurate and comprehensive measurements in a space vehicle. The successful integration and commercialization of micro- and nanotechnology for aerospace applications require that a close and interactive relationship be developed between the technology provider and the end user early in the project. Close coordination between the developers and the end users is critical since qualification for flight is time-consuming and expensive. The successful integration of micro- and nanotechnology into space vehicles requires a coordinated effort throughout the design, development, installation, and integration processes

Bio oil synthesis by coupling biological biomass pretreatment and catalytic hydroliquefaction process.

PubMed

Hamieh, S; Beauchet, R; Lemee, L; Toufaily, J; Koubaissy, B; Hamieh, T; Pouilloux, Y; Pinard, L

2014-03-01

The bio-oil synthesis from a mixture of wastes (7wt.% straw, 38wt.% wood, and 45wt.% grass) was carried out by direct liquefaction reaction using Raney Nickel as catalyst and tetralin as solvent. The green wastes were biologically degraded during 3 months. Longer the destructuration time; higher the yield into oil is. Biological pretreatment of green wastes promotes the liquefaction process. Among the components of degraded biomass, Humin, the major fraction (60-80wt.%) that was favored by the biological treatment, yields to a bio oil extremely energetic with a HHV close to biopetroleum (40MJ kg(-1)), contrariwise, Fulvic acids (2-12wt.%), the minor fraction is refractory to liquefaction reaction. Copyright © 2014 Elsevier Ltd. All rights reserved.

A proposed framework on hybrid feature selection techniques for handling high dimensional educational data

NASA Astrophysics Data System (ADS)

Shahiri, Amirah Mohamed; Husain, Wahidah; Rashid, Nur'Aini Abd

2017-10-01

Huge amounts of data in educational datasets may cause the problem in producing quality data. Recently, data mining approach are increasingly used by educational data mining researchers for analyzing the data patterns. However, many research studies have concentrated on selecting suitable learning algorithms instead of performing feature selection process. As a result, these data has problem with computational complexity and spend longer computational time for classification. The main objective of this research is to provide an overview of feature selection techniques that have been used to analyze the most significant features. Then, this research will propose a framework to improve the quality of students' dataset. The proposed framework uses filter and wrapper based technique to support prediction process in future study.

Estimating Viscoelastic Deformation Due to Seasonal Loading

NASA Technical Reports Server (NTRS)

Sauber, Jeanne

2015-01-01

Scientists have been making summer-­-time geodetic measurements in south central Alaska for decades to estimate the rate at which a continental-­-ocean terrane is accreting to the North American continent. Southern Alaska has big earthquakes every century and large, rapidly changing glaciers. In the last decade, primarily as part of the EarthScope Plate Boundary Observatory project, continuous GPS measurements have recorded the response of sites such as the near-­-coastal geodetic site, AB35 to competing processes: uplift and movement to the northwest due to tectonic forces and the response of the solid Earth to seasonal and longer-­-term changes in the cryosphere (snow and ice) surrounding the site. Which process causes the largest displacements of the site? Figure 1 (Blewitt, Nevada Geodetic Lab, 2015) shows the Northward, Eastward, and Upward motion of AB35 between 2007 and 2015. The site is moving rapidly to the north and west reflecting the tectonic convergence of site toward interior Alaska but there is small wiggle on the North component reflecting seasonal displacements of the site associated with snow loading and unloading. However, the Up component, shows a large seasonal signal due to snow loading in the winter (down) and ice and snow melting in the warmer months (site goes up). Between 2007 and the present, the site position is slowly moving upward, due to tectonic forcing but probably associated with longer-­- term ice melting as well. We are using the CIG finite element modeling (FEM) program Pylith to estimate the surface displacements and stresses associated with seasonal loading changes (top figure and Figure 2 far right) for water year 2012, 2011.8 - 2012.8) and the longer-­-term retreat of the surrounding glaciers.

Effects of age on cognitive control during semantic categorization.

PubMed

Mudar, Raksha A; Chiang, Hsueh-Sheng; Maguire, Mandy J; Spence, Jeffrey S; Eroh, Justin; Kraut, Michael A; Hart, John

2015-01-01

We used event-related potentials (ERPs) to study age effects of perceptual (basic-level) vs. perceptual-semantic (superordinate-level) categorization on cognitive control using the go/nogo paradigm. Twenty-two younger (11 M; 21 ± 2.2 years) and 22 older adults (9 M; 63 ± 5.8 years) completed two visual go/nogo tasks. In the single-car task (SiC) (basic), go/nogo responses were made based on single exemplars of a car (go) and a dog (nogo). In the object animal task (ObA) (superordinate), responses were based on multiple exemplars of objects (go) and animals (nogo). Each task consisted of 200 trials: 160 (80%) 'go' trials that required a response through button pressing and 40 (20%) 'nogo' trials that required inhibition/withholding of a response. ERP data revealed significantly reduced nogo-N2 and nogo-P3 amplitudes in older compared to younger adults, whereas go-N2 and go-P3 amplitudes were comparable in both groups during both categorization tasks. Although the effects of categorization levels on behavioral data and P3 measures were similar in both groups with longer response times, lower accuracy scores, longer P3 latencies, and lower P3 amplitudes in ObA compared to SiC, N2 latency revealed age group differences moderated by the task. Older adults had longer N2 latency for ObA compared to SiC, in contrast, younger adults showed no N2 latency difference between SiC and ObA. Overall, these findings suggest that age differentially affects neural processing related to cognitive control during semantic categorization. Furthermore, in older adults, unlike in younger adults, levels of categorization modulate neural processing related to cognitive control even at the early stages (N2). Published by Elsevier B.V.

Plasma clearance of neostigmine and pyridostigmine in the dog.

PubMed Central

Baker, P R; Calvey, T N; Chan, K; Macnee, C M; Taylor, K

1978-01-01

1 The pharmacokinetics of neostigmine and pyridostigmine was studied in conscious dogs by the use of a cross-over design. 2 Both neostigmine and pyridostigmine were cleared from plasma in a biexponential manner. 3 The apparent volume of distribution of pyridostigmine was invariably greater than that of neostigmine, and its fast disposition half-life was approximately three times longer. 4 The whole body clearance and the urinary elimination of pyridostigmine was approximately twice that of neostigmine. 5 The slow disposition half-life of pyridostigmine was approximately three times longer than that of neostigmine, suggesting that the longer duration of action of pyridostigmine is related to the differential clearance of the two quarternary amines from plasma. PMID:667495

Stabilized micelles as delivery vehicles for paclitaxel.

PubMed

Yoncheva, Krassimira; Calleja, Patricia; Agüeros, Maite; Petrov, Petar; Miladinova, Ivanka; Tsvetanov, Christo; Irache, Juan M

2012-10-15

Paclitaxel is an antineoplastic drug used against a variety of tumors, but its low aqueous solubility and active removal caused by P-glycoprotein in the intestinal cells hinder its oral administration. In our study, new type of stabilized Pluronic micelles were developed and evaluated as carriers for paclitaxel delivery via oral or intravenous route. The pre-stabilized micelles were loaded with paclitaxel by simple solvent/evaporation technique achieving high encapsulation efficiency of approximately 70%. Gastrointestinal transit of the developed micelles was evaluated by oral administration of rhodamine-labeled micelles in rats. Our results showed prolonged gastrointestinal residence of the marker encapsulated into micelles, compared to a solution containing free marker. Further, the oral administration of micelles in mice showed high area under curve of micellar paclitaxel (similar to the area of i.v. Taxol(®)), longer mean residence time (9-times longer than i.v. Taxol(®)) and high distribution volume (2-fold higher than i.v. Taxol(®)) indicating an efficient oral absorption of paclitaxel delivered by micelles. Intravenous administration of micelles also showed a significant improvement of pharmacokinetic parameters of micellar paclitaxel vs. Taxol(®), in particular higher area under curve (1.2-fold), 5-times longer mean residence time and lower clearance, indicating longer systemic circulation of the micelles. Copyright © 2012 Elsevier B.V. All rights reserved.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Uberuaga, Blas Pedro; Voter, Arthur F; Perez, Danny

A long-standing limitation in the use of molecular dynamics (MD) simulation is that it can only be applied directly to processes that take place on very short timescales: nanoseconds if empirical potentials are employed, or picoseconds if we rely on electronic structure methods. Many processes of interest in chemistry, biochemistry, and materials science require study over microseconds and beyond, due either to the natural timescale for the evolution or to the duration of the experiment of interest. Ignoring the case of liquids xxx, the dynamics on these time scales is typically characterized by infrequent-event transitions, from state to state, usuallymore » involving an energy barrier. There is a long and venerable tradition in chemistry of using transition state theory (TST) [10, 19, 23] to directly compute rate constants for these kinds of activated processes. If needed dynamical corrections to the TST rate, and even quantum corrections, can be computed to achieve an accuracy suitable for the problem at hand. These rate constants then allow them to understand the system behavior on longer time scales than we can directly reach with MD. For complex systems with many reaction paths, the TST rates can be fed into a stochastic simulation procedure such as kinetic Monte Carlo xxx, and a direct simulation of the advance of the system through its possible states can be obtained in a probabilistically exact way. A problem that has become more evident in recent years, however, is that for many systems of interest there is a complexity that makes it difficult, if not impossible, to determine all the relevant reaction paths to which TST should be applied. This is a serious issue, as omitted transition pathways can have uncontrollable consequences on the simulated long-time kinetics. Over the last decade or so, we have been developing a new class of methods for treating the long-time dynamics in these complex, infrequent-event systems. Rather than trying to guess in advance what reaction pathways may be important, we return instead to a molecular dynamics treatment, in which the trajectory itself finds an appropriate way to escape from each state of the system. Since a direct integration of the trajectory would be limited to nanoseconds, while we are seeking to follow the system for much longer times, we modify the dynamics in some way to cause the first escape to happen much more quickly, thereby accelerating the dynamics. The key is to design the modified dynamics in a way that does as little damage as possible to the probability for escaping along a given pathway - i.e., we try to preserve the relative rate constants for the different possible escape paths out of the state. We can then use this modified dynamics to follow the system from state to state, reaching much longer times than we could reach with direct MD. The dynamics within any one state may no longer be meaningful, but the state-to-state dynamics, in the best case, as we discuss in the paper, can be exact. We have developed three methods in this accelerated molecular dynamics (AMD) class, in each case appealing to TST, either implicitly or explicitly, to design the modified dynamics. Each of these methods has its own advantages, and we and others have applied these methods to a wide range of problems. The purpose of this article is to give the reader a brief introduction to how these methods work, and discuss some of the recent developments that have been made to improve their power and applicability. Note that this brief review does not claim to be exhaustive: various other methods aiming at similar goals have been proposed in the literature. For the sake of brevity, our focus will exclusively be on the methods developed by the group.« less

Do presenting symptoms explain sex differences in emergency department delays among patients with acute stroke?

PubMed

Gargano, Julia Warner; Wehner, Susan; Reeves, Mathew J

2009-04-01

Previous studies report that women with stroke may experience longer delays in diagnostic workup than men after arriving at the emergency department. We hypothesized that presenting symptom differences could explain these delays. Data were collected on 1922 acute stroke cases who presented to 15 hospitals participating in a statewide stroke registry. We evaluated 2 in-hospital time intervals: emergency department arrival to physician examination ("door-to-doctor") and emergency department arrival to brain imaging ("door-to-image"). We used parametric survival models to estimate time ratios, which represent the ratio of average times comparing women to men, after adjusting for symptom presentation and other confounders. Women were significantly less likely than men to present with any stroke warning sign or suspected stroke (87.5% versus 91.4%) or to report trouble with walking, balance, or dizziness (9.5% versus 13.7%). Difficulty speaking and loss of consciousness were associated with shorter door-to-doctor times. Weakness, facial droop, difficulty speaking, and loss of consciousness were associated with shorter door-to-image times, whereas difficulty with walking/balance was associated with longer door-to-image times. In adjusted analyses, women had 11% longer door-to-doctor intervals (time ratio, 1.11; 95%, CI 1.02 to 1.22) and 15% longer door-to-image intervals (time ratio, 1.15; 95% CI, 1.08 to 1.25) after accounting for presenting symptoms, age, and other confounders. Furthermore, these sex differences remained evident after restricting to patients who arrived within 6 or within 2 hours of symptom onset. Women with acute stroke experienced greater emergency department delays than men, which were not attributable to differences in presenting symptoms, time of arrival, age, or other confounders.

Effects of illuminants and illumination time on lettuce growth, yield and nutritional quality in a controlled environment

NASA Astrophysics Data System (ADS)

Shen, Y. Z.; Guo, S. S.; Ai, W. D.; Tang, Y. K.

2014-07-01

Effects of illuminants and illumination time on the growth of lettuce were researched. Red-blue light-emitting diodes (LEDs, 90% red light +10% blue light) and white light fluorescent (WF) lamps were compared as the illuminants for plant cultivation. Under each type of illuminant, lettuce was grown at 4 illumination times: 12 h, 16 h, 20 h and 24 h, with the same light intensity of 600 μmolm-2s-1. The leaf net photosynthetic rate (Pn) under the two illuminants was comparable but the shape of lettuce was obviously affected by the illuminant. The WF lamps produced more compact plant, while red-blue LED resulted in less but longer leaves. However, the total leaf area was not significantly affected by the illuminant. The red-blue LED produced nearly same aboveground biomass with far less energy consumption relative to WF lamps. The underground biomass was lowered under red-blue LED in comparison with WF lamps. Red-blue LED could improve the nutritional quality of lettuce by increasing the concentration of soluble sugar and vitamin C (VC) and reducing the concentration of nitrate. Under each type of illuminant, longer illumination time resulted in higher Pn, more leaves and larger leaf area. The total chlorophyll concentration increased while the concentration ratio of chlorophyll a/b decreased with the extension of illumination time. Illumination time had highly significant positive correlation with biomass. Moreover, when total daily light input was kept the same, longer illumination time increased the biomass significantly as well. In addition, longer illumination time increased the concentration of crude fiber, soluble sugar and VC and reduced the concentration of nitrate. In summary, red-blue LEDs and 24 h illumination time were demonstrated to be more suitable for lettuce cultivation in the controlled environment.

The neural dynamics of stimulus and response conflict processing as a function of response complexity and task demands

PubMed Central

Donohue, Sarah E.; Appelbaum, Lawrence G.; McKay, Cameron C.; Woldorff, Marty G.

2016-01-01

Both stimulus and response conflict can disrupt behavior by slowing response times and decreasing accuracy. Although several neural activations have been associated with conflict processing, it is unclear how specific any of these are to the type of stimulus conflict or the amount of response conflict. Here, we recorded electrical brain activity, while manipulating the type of stimulus conflict in the task (spatial [Flanker] versus semantic [Stroop]) and the amount of response conflict (two versus four response choices). Behaviorally, responses were slower to incongruent versus congruent stimuli across all task and response types, along with overall slowing for higher response-mapping complexity. The earliest incongruency-related neural effect was a short-duration frontally-distributed negativity at ~200 ms that was only present in the Flanker spatial-conflict task. At longer latencies, the classic fronto-central incongruency-related negativity ‘Ninc’ was observed for all conditions, which was larger and ~100 ms longer in duration with more response options. Further, the onset of the motor-related lateralized readiness potential (LRP) was earlier for the two vs. four response sets, indicating that smaller response sets enabled faster motor-response preparation. The late positive complex (LPC) was present in all conditions except the two-response Stroop task, suggesting this late conflict-related activity is not specifically related to task type or response-mapping complexity. Importantly, across tasks and conditions, the LRP onset at or before the conflict-related Ninc, indicating that motor preparation is a rapid, automatic process that interacts with the conflict-detection processes after it has begun. Together, these data highlight how different conflict-related processes operate in parallel and depend on both the cognitive demands of the task and the number of response options. PMID:26827917

The neural dynamics of stimulus and response conflict processing as a function of response complexity and task demands.

PubMed

Donohue, Sarah E; Appelbaum, Lawrence G; McKay, Cameron C; Woldorff, Marty G

2016-04-01

Both stimulus and response conflict can disrupt behavior by slowing response times and decreasing accuracy. Although several neural activations have been associated with conflict processing, it is unclear how specific any of these are to the type of stimulus conflict or the amount of response conflict. Here, we recorded electrical brain activity, while manipulating the type of stimulus conflict in the task (spatial [Flanker] versus semantic [Stroop]) and the amount of response conflict (two versus four response choices). Behaviorally, responses were slower to incongruent versus congruent stimuli across all task and response types, along with overall slowing for higher response-mapping complexity. The earliest incongruency-related neural effect was a short-duration frontally-distributed negativity at ~200 ms that was only present in the Flanker spatial-conflict task. At longer latencies, the classic fronto-central incongruency-related negativity 'N(inc)' was observed for all conditions, but was larger and ~100 ms longer in duration with more response options. Further, the onset of the motor-related lateralized readiness potential (LRP) was earlier for the two vs. four response sets, indicating that smaller response sets enabled faster motor-response preparation. The late positive complex (LPC) was present in all conditions except the two-response Stroop task, suggesting this late conflict-related activity is not specifically related to task type or response-mapping complexity. Importantly, across tasks and conditions, the LRP onset at or before the conflict-related N(inc), indicating that motor preparation is a rapid, automatic process that interacts with the conflict-detection processes after it has begun. Together, these data highlight how different conflict-related processes operate in parallel and depend on both the cognitive demands of the task and the number of response options. Copyright © 2016 Elsevier Ltd. All rights reserved.

Variability in Proactive and Reactive Cognitive Control Processes Across the Adult Lifespan

PubMed Central

Karayanidis, Frini; Whitson, Lisa Rebecca; Heathcote, Andrew; Michie, Patricia T.

2011-01-01

Task-switching paradigms produce a highly consistent age-related increase in mixing cost [longer response time (RT) on repeat trials in mixed-task than single-task blocks] but a less consistent age effect on switch cost (longer RT on switch than repeat trials in mixed-task blocks). We use two approaches to examine the adult lifespan trajectory of control processes contributing to mixing cost and switch cost: latent variables derived from an evidence accumulation model of choice, and event-related potentials (ERP) that temporally differentiate proactive (cue-driven) and reactive (target-driven) control processes. Under highly practiced and prepared task conditions, aging was associated with increasing RT mixing cost but reducing RT switch cost. Both effects were largely due to the same cause: an age effect for mixed-repeat trials. In terms of latent variables, increasing age was associated with slower non-decision processes, slower rate of evidence accumulation about the target, and higher response criterion. Age effects on mixing costs were evident only on response criterion, the amount of evidence required to trigger a decision, whereas age effects on switch cost were present for all three latent variables. ERPs showed age-related increases in preparation for mixed-repeat trials, anticipatory attention, and post-target interference. Cue-locked ERPs that are linked to proactive control were associated with early emergence of age differences in response criterion. These results are consistent with age effects on strategic processes controlling decision caution. Consistent with an age-related decline in cognitive flexibility, younger adults flexibly adjusted response criterion from trial-to-trial on mixed-task blocks, whereas older adults maintained a high criterion for all trials. PMID:22073037

Factors associated with self-estimated work ability and musculoskeletal symptoms among male and female workers in cooled food-processing facilities.

PubMed

Sormunen, Erja; Remes, Jouko; Hassi, Juhani; Pienimäki, Tuomo; Rintamäki, Hannu

2009-07-01

This questionnaire study evaluates how work ability and musculoskeletal symptoms associate with physical work factors and individual characteristics of the workers in cooled food-processing facilities. A total of 1,117 workers (response rate 85%) responded to the study. Poor work ability was significantly associated with longer work duration, experience of draught at the workplace, absence from work due to health reasons, and physical inactivity during free time. The amount of local cooling experienced was significantly associated with the risk for musculoskeletal symptoms in the neck-shoulder region, shoulders, wrists and lower back. Additionally, female gender, longer work duration and poor work ability were associated with the increased prevalence of the symptoms. The prevalence of musculoskeletal symptoms was significantly higher among older employees (40 to 64 yr) than among younger employees (18 to 39 yr) for all regions except wrists. Cold discomfort and unpleasant sensations due to the physical factors of work were significantly more common among females than males. The results showed that, in addition to individual characteristics of workers, factors related to work in a cool environment (experience of draught and cooling and long exposure to cold) are associated with poor work ability and musculoskeletal symptoms.

Floral development at multiple spatial scales in Polygonum jucundum (Polygonaceae), a distylous species with broadly open flowers.

PubMed

Huang, Lan-Jie; Fu, Wen-Long; Wang, Xiao-Fan

2014-01-01

Distyly, a special polymorph, has evolved in many groups of angiosperms and has attracted attention since Darwin's time. Development studies on distylous taxa have helped us to understand the evolutionary process of this polymorph, but most of these studies focus on species with narrowly tubular corolla. Here, we studied the floral development of Polygonum jucundum, a distylous species with broadly open flowers, at multiple spatial scales. Results showed that the difference in stigma height between flowers of the two morphs was caused by differences in style growth throughout the entire floral development process. The observed difference in anther heights between the two morphs was because the filaments grew faster in short-styled (SS) than in long-styled (LS) flowers in the later stages of floral development. In addition, the longer styles in LS flowers than in SS flowers was because of faster cell division in the early stages of floral development. However, SS flowers had longer filaments than LS flowers primarily because of greater cell elongation. These results indicate that floral development in P. jucundum differs from that of distylous taxa with floral tubes shown in previous studies. Further, we conclude that the presence of distyly in species with open flowers is a result of convergent evolution.

Benchmark eye movement effects during natural reading in autism spectrum disorder.

PubMed

Howard, Philippa L; Liversedge, Simon P; Benson, Valerie

2017-01-01

In 2 experiments, eye tracking methodology was used to assess on-line lexical, syntactic and semantic processing in autism spectrum disorder (ASD). In Experiment 1, lexical identification was examined by manipulating the frequency of target words. Both typically developed (TD) and ASD readers showed normal frequency effects, suggesting that the processes TD and ASD readers engage in to identify words are comparable. In Experiment 2, syntactic parsing and semantic interpretation requiring the on-line use of world knowledge were examined, by having participants read garden path sentences containing an ambiguous prepositional phrase. Both groups showed normal garden path effects when reading low-attached sentences and the time course of reading disruption was comparable between groups. This suggests that not only do ASD readers hold similar syntactic preferences to TD readers, but also that they use world knowledge on-line during reading. Together, these experiments demonstrate that the initial construction of sentence interpretation appears to be intact in ASD. However, the finding that ASD readers skip target words less often in Experiment 2, and take longer to read sentences during second pass for both experiments, suggests that they adopt a more cautious reading strategy and take longer to evaluate their sentence interpretation prior to making a manual response. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

Reading laterally: the cerebral hemispheric use of spatial frequencies in visual word recognition.

PubMed

Tadros, Karine; Dupuis-Roy, Nicolas; Fiset, Daniel; Arguin, Martin; Gosselin, Frédéric

2013-01-04

It is generally accepted that the left hemisphere (LH) is more capable for reading than the right hemisphere (RH). Left hemifield presentations (initially processed by the RH) lead to a globally higher error rate, slower word identification, and a significantly stronger word length effect (i.e., slower reaction times for longer words). Because the visuo-perceptual mechanisms of the brain for word recognition are primarily localized in the LH (Cohen et al., 2003), it is possible that this part of the brain possesses better spatial frequency (SF) tuning for processing the visual properties of words than the RH. The main objective of this study is to determine the SF tuning functions of the LH and RH for word recognition. Each word image was randomly sampled in the SF domain using the SF bubbles method (Willenbockel et al., 2010) and was presented laterally to the left or right visual hemifield. As expected, the LH requires less visual information than the RH to reach the same level of performance, illustrating the well-known LH advantage for word recognition. Globally, the SF tuning of both hemispheres is similar. However, these seemingly identical tuning functions hide important differences. Most importantly, we argue that the RH requires higher SFs to identify longer words because of crowding.

Can working memory predict target-to-target interval effects in the P300?

PubMed

Steiner, Genevieve Z; Barry, Robert J; Gonsalvez, Craig J

2013-09-01

It has been suggested that the P300 component of the ERP is an electrophysiological index of memory-updating processes associated with task-relevant stimuli. Component magnitude varies with the time separating target stimuli (target-to-target interval: TTI), with longer TTIs eliciting larger P300 amplitudes. According to the template-update perspective, TTI effects observable in the P300 reflect the updating of stimulus-templates in working memory (WM). The current study explored whether young adults' memory-task ability could predict TTI effects in P300. EEG activity was recorded from 50 university students (aged 18-25 years) while they completed an auditory equiprobable Go/NoGo task with manipulations of TTIs. Participants also completed a CogState® battery and were sorted according to their WM score. ERPs were analysed using a temporal PCA. Two P300 components, P3b and the Slow Wave, were found to linearly increase in amplitude to longer TTIs. This TTI effect differed between groups only for the P3b component: The high WM group showed a steeper increase in P3b amplitude with TTI than the low WM group. These results suggest that TTI effects in P300 are directly related to WM processes. © 2013.

Selective Strolls: Fixation and Extinction in Diploids Are Slower for Weakly Selected Mutations Than for Neutral Ones.

PubMed

Mafessoni, Fabrizio; Lachmann, Michael

2015-12-01

In finite populations, an allele disappears or reaches fixation due to two main forces, selection and drift. Selection is generally thought to accelerate the process: a selected mutation will reach fixation faster than a neutral one, and a disadvantageous one will quickly disappear from the population. We show that even in simple diploid populations, this is often not true. Dominance and recessivity unexpectedly slow down the evolutionary process for weakly selected alleles. In particular, slightly advantageous dominant and mildly deleterious recessive mutations reach fixation slightly more slowly than neutral ones (at most 5%). This phenomenon determines genetic signatures opposite to those expected under strong selection, such as increased instead of decreased genetic diversity around the selected site. Furthermore, we characterize a new phenomenon: mildly deleterious recessive alleles, thought to represent a wide fraction of newly arising mutations, on average survive in a population slightly longer than neutral ones, before getting lost. Consequently, these mutations are on average slightly older than neutral ones, in contrast with previous expectations. Furthermore, they slightly increase the amount of weakly deleterious polymorphisms, as a consequence of the longer unconditional sojourn times compared to neutral mutations. Copyright © 2015 by the Genetics Society of America.

Sex differences in a chronometric mental rotation test with cube figures: a behavioral, electroencephalography, and eye-tracking pilot study.

PubMed

Scheer, Clara; Mattioni Maturana, Felipe; Jansen, Petra

2018-05-07

In chronometric mental rotation tasks, sex differences are widely discussed. Most studies find men to be more skilled in mental rotation than women, which can be explained by the holistic strategy that they use to rotate stimuli. Women are believed to apply a piecemeal strategy. So far, there have been no studies investigating this phenomenon using eye-tacking methods in combination with electroencephalography (EEG) analysis: the present study compared behavioral responses, EEG activity, and eye movements of 15 men and 15 women while solving a three-dimensional chronometric mental rotation test. The behavioral analysis showed neither differences in reaction time nor in the accuracy rate between men and women. The EEG data showed a higher right activation on parietal electrodes for women and the eye-tracking results indicated a longer fixation in a higher number of areas of interest at 0° for women. Men and women are likely to possess different perceptual (visual search) and decision-making mechanisms, but similar mental rotation processes. Furthermore, men presented a longer visual search processing, characterized by the greater saccade latency of 0°-135°. Generally, this study could be considered a pilot study to investigate sex differences in mental rotation tasks while combining eye-tracking and EEG methods.

Effect of a photoperiodic green light programme during incubation on embryo development and hatch process.

PubMed

Tong, Q; McGonnell, I M; Demmers, T G M; Roulston, N; Bergoug, H; Romanini, C E; Verhelst, R; Guinebretière, M; Eterradossi, N; Berckmans, D; Exadaktylos, V

2018-04-01

This study was conducted to evaluate the effect of a 12-h light, 12-h dark (12L : 12D) photoperiod of green light during day 1 to day 18 of incubation time, on embryo growth, hormone concentration and the hatch process. In the test group, monochromatic light was provided by a total of 204 green light-emitting diodes (522 nm) mounted in a frame which was placed above the top tray of eggs to give even spread of illumination. No light-dark cycle was used in the control group. Four batches of eggs (n=300/group per batch) from fertile Ross 308 broiler breeders were used in this experiment. The beak length and crown-rump length of embryos incubated under green light were significantly longer than that of control embryos at day 10 and day 12, respectively (P<0.01). Furthermore, green light-exposed embryos had a longer third toe length compared with control embryos at day 10, day 14 and day 17 (P=0.02). At group level (n=4 batches), light stimulation had no effect on chick weight and quality at take-off, the initiation of hatch and hatch window. However, the individual hatching time of the light exposure focal chicks (n=33) was 3.4 h earlier (P=0.49) than the control focal chicks (n=36) probably due to the change in melatonin rhythm of the light group. The results of this study indicate that green light accelerates embryo development and alters hatch-related hormones (thyroid and corticosterone), which may result in earlier hatching.

[Survival elongation of Pseudomonas aeruginosa improves power output of microbial fuel cells].

PubMed

You, Ting; Liu, Jihua; Liang, Rubing; Liu, Jianhua

2017-04-25

The secondary metabolites, phenazine products, produced by Pseudomonas aeruginosa can mediate the electrons transfer in microbial fuel cells (MFCs). How increase the total electricity production in MFCs by improving the characteristics of Pseudomonas aeruginosa is one of research hot spots and problems. In this study, P. aeruginosa strain SJTD-1 and its knockout mutant strain SJTD-1 (ΔmvaT) were used to construct MFCs, and the discharge processes of the two MFCs were analyzed to determine the key factors to electricity yields. Results indicated that not only phenazine but also the viable cells in the fermentation broth were essential for the discharge of MFCs. The mutant strain SJTD-1 (ΔmvaT) could produce more phenazine products and continue discharging over 160 hours in MFCs, more than that of the wild-type SJTD-1 strain (90 hours discharging time). The total electricity generated by SJTD-1 (ΔmvaT) strain could achieve 2.32 J in the fermentation process, much higher than the total 1.30 J electricity of the wild-type SJTD-1 strain. Further cell growth analysis showed that the mutant strain SJTD-1 (ΔmvaT) could keep a longer stationary period, survive much longer in MFCs and therefore, discharge more electron than those of the wild-type SJTD-1 strain. Therefore, the cell survival elongation of P. aeruginosa in MFCs could enhance its discharging time and improve the overall energy yield. This work could give a clue to improve the characteristics of MFCs using genetic engineering strain, and could promote related application studies on MFCs.

Processing and microstructural characterisation of a UO2-based ceramic for disposal studies on spent AGR fuel

NASA Astrophysics Data System (ADS)

Hiezl, Z.; Hambley, D. I.; Padovani, C.; Lee, W. E.

2015-01-01

Preparation and characterisation of a Simulated Spent Nuclear Fuel (SIMFuel), which replicates the chemical state and microstructure of Spent Nuclear Fuel (SNF) discharged from a UK Advanced Gas-cooled Reactor (AGR) after a cooling time of 100 years is described. Given the relatively small differences in radionuclide inventory expected over longer time periods, the SIMFuel studied in this work is expected to be also representative of spent fuel after significantly longer periods (e.g. 1000 years). Thirteen stable elements were added to depleted UO2 and sintered to simulate the composition of fuel pellets after burn-ups of 25 and 43 GWd/tU and, as a reference, pure UO2 pellets were also investigated. The fission product distribution was calculated using the FISPIN code provided by the UK National Nuclear Laboratory. SIMFuel pellets were up to 92% dense and during the sintering process in H2 atmosphere Mo-Ru-Rh-Pd metallic precipitates and grey-phase ((Ba, Sr)(Zr, RE) O3 oxide precipitates) formed within the UO2 matrix. These secondary phases are present in real PWR and AGR SNF. Metallic precipitates are generally spherical and have submicron particle size (0.8 ± 0.7 μm). Spherical oxide precipitates in SIMFuel measured up to 30 μm in diameter, but no data were available in the public domain to compare this to AGR SNF. The grain size of actual AGR SNF (∼ 3-30 μm) is larger than that measured in AGR SIMFuel (∼ 2-5 μm).

Rapid detection of chlorpyrifos pesticide residue concentration in agro-product using Raman spectroscopy

NASA Astrophysics Data System (ADS)

Dhakal, Sagar; Peng, Yankun; Li, Yongyu; Chao, Kuanglin; Qin, Jianwei; Zhang, Leilei; Xu, Tianfeng

2014-05-01

Different chemicals are sprayed in fruits and vegetables before and after harvest for better yield and longer shelf-life of crops. Cases of pesticide poisoning to human health are regularly reported due to excessive application of such chemicals for greater economic benefit. Different analytical technologies exist to detect trace amount of pesticides in fruits and vegetables, but are expensive, sample destructive, and require longer processing time. This study explores the application of Raman spectroscopy for rapid and non-destructive detection of pesticide residue in agricultural products. Raman spectroscopy with laser module of 785 nm was used to collect Raman spectral information from the surface of Gala apples contaminated with different concentrations of commercially available organophosphorous (48% chlorpyrifos) pesticide. Apples within 15 days of harvest from same orchard were used in this study. The Raman spectral signal was processed by Savitzky-Golay (SG) filter for noise removal, Multiplicative Scatter Correction (MSC) for drift removal and finally polynomial fitting was used to eliminate the fluorescence background. The Raman spectral peak at 677 cm-1 was recognized as Raman fingerprint of chlorpyrifos. Presence of Raman peak at 677 cm-1 after fluorescence background removal was used to develop classification model (presence and absence of pesticide). The peak intensity was correlated with actual pesticide concentration obtained using Gas Chromatography and MLR prediction model was developed with correlation coefficient of calibration and validation of 0.86 and 0.81 respectively. Result shows that Raman spectroscopy is a promising tool for rapid, real-time and non-destructive detection of pesticide residue in agro-products.