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Sample records for los siglos xii

  1. Factor XII Contact Activation.

    PubMed

    Naudin, Clément; Burillo, Elena; Blankenberg, Stefan; Butler, Lynn; Renné, Thomas

    2017-03-27

    Contact activation is the surface-induced conversion of factor XII (FXII) zymogen to the serine protease FXIIa. Blood-circulating FXII binds to negatively charged surfaces and this contact to surfaces triggers a conformational change in the zymogen inducing autoactivation. Several surfaces that have the capacity for initiating FXII contact activation have been identified, including misfolded protein aggregates, collagen, nucleic acids, and platelet and microbial polyphosphate. Activated FXII initiates the proinflammatory kallikrein-kinin system and the intrinsic coagulation pathway, leading to formation of bradykinin and thrombin, respectively. FXII contact activation is well characterized in vitro and provides the mechanistic basis for the diagnostic clotting assay, activated partial thromboplastin time. However, only in the past decade has the critical role of FXII contact activation in pathological thrombosis been appreciated. While defective FXII contact activation provides thromboprotection, excess activation underlies the swelling disorder hereditary angioedema type III. This review provides an overview of the molecular basis of FXII contact activation and FXII contact activation-associated disease states.

  2. Characterization of factor XII Tenri, a rare CRM-negative factor XII deficiency.

    PubMed

    Fujihara, Noriko; Tozuka, Minoru; Yamauchi, Kazuyoshi; Ueno, Ichiro; Urasawa, Nobuyuki; Ishikawa, Shinsuke; Hirota-Kawadobora, Masako; Okumura, Nobuo; Hidaka, Hiroya; Katsuyama, Tsutomu

    2004-01-01

    Factor XII Tenri (Y34C), a rare cross-reacting material (CRM)-negative factor XII deficiency, was identified in a 71-yr-old Japanese woman with angina pectoris. In the patient's plasma, factor XII activity and antigen levels were only 1.6% and 5.0%, respectively, of those seen in a normal subject. Immunoblot analysis showed that the secreted factor XII Tenri existed not only as a monomer (76 kDa), but also in complexes with apparent molecular weights of approximately 115, 140, 190, 215, and 225 kDa. After reduction with 2-mercaptoethanol, the factor XII Tenri contained in the complexes was completely converted to monomeric form on immunoblot patterns. It appeared that some of the secreted factor XII Tenri formed several types of disulfide-linked complexes, including a factor XII-alpha1-microglobulin complex, through a newly generated Cys residue. The monomeric form of factor XII Tenri, like normal factor XII, was degraded into 2 major fragments with molecular weights of approximately 45 kDa and 30 kDa following mixing with activated partial-thromboplastin-time measuring reagent (cephalin and ellagic acid), whereas the factor XII Tenri that formed the complexes was not. This indicates that the factor XII Tenri present in disulfide-linked complexes with other proteins (and itself) is not converted to active forms, suggesting that attached proteins obstruct or delay the activation of factor XII via an inhibition of its binding to a negatively charged surface in vitro.

  3. ADASS XII Meeting Web Site

    NASA Astrophysics Data System (ADS)

    Liou, C.; Hulbert, S.

    We present the architecture, design, and implementation details of the ADASS XII web site. The web site was implemented in Zope, a high-performance application server, web server, and content management system rolled into one. Zope includes a robust, scalable object database, web services architecture, and powerful programming capabilities. The web site was built to conform to HTML, CSS, and accessibility standards as adopted by the W3C. This dynamic web site also taps into a back-end Sybase database while requiring a minimal amount of coding. We offer this site as a prototype web site suitable for reuse in supporting future ADASS meetings.

  4. Activation of factor XII by tobacco glycoprotein.

    PubMed

    Becker, C G; Dubin, T

    1977-08-01

    A glycoprotein of mol wt ca. 18,000 daltons isolated from cured tobacco leaves (TGP-L) and from cigarette smoke condensate (TGP-CSC) activated factor XII in normal human plasma in vitro as measured by (a) shortening of the partial thromboplastin time, (b) shortening of the lysis time of euglobulin clots, and (c) generation of kinin activity. These effects were not demonstrable in plasma deficient in factor XII. The capacity of TGP-L and TGP-CSC to activate factor XII was shown to depend on the presence of rutin, a substance chemically similar to quercetin and ellagic acid, which are known activators of factor XII. Rutin and rutin coupled to bovine serum albumin, but not bovine serum albumin alone, were also demonstrated to activate factor XII. The presence in cigarette smoke of material that is both allergenic and capable of activating factor XII of the intrinsic pathway of coagulatin may be important to the pathogenesis of cardiovascular and pulmonary disease associated with cigarette smoking.

  5. Activation of factor XII by tobacco glycoprotein

    PubMed Central

    1977-01-01

    A glycoprotein of mol wt ca. 18,000 daltons isolated from cured tobacco leaves (TGP-L) and from cigarette smoke condensate (TGP-CSC) activated factor XII in normal human plasma in vitro as measured by (a) shortening of the partial thromboplastin time, (b) shortening of the lysis time of euglobulin clots, and (c) generation of kinin activity. These effects were not demonstrable in plasma deficient in factor XII. The capacity of TGP-L and TGP-CSC to activate factor XII was shown to depend on the presence of rutin, a substance chemically similar to quercetin and ellagic acid, which are known activators of factor XII. Rutin and rutin coupled to bovine serum albumin, but not bovine serum albumin alone, were also demonstrated to activate factor XII. The presence in cigarette smoke of material that is both allergenic and capable of activating factor XII of the intrinsic pathway of coagulatin may be important to the pathogenesis of cardiovascular and pulmonary disease associated with cigarette smoking. PMID:874423

  6. [XII National Forum on Health Education].

    PubMed

    Ramiro-H, Manuel

    2015-01-01

    In Guadalajara, on August 19, 20 and 21 was held the XII Foro Nacional de Educación en Salud, in line with the interest that both, the Dirección General and the Dirección de Prestaciones Médicas of the IMSS, have in training and updating the human resources for the care of the beneficiaries. The Unidad de Educación, Investigación y Políticas de Salud organized a meeting in which the actors of these tasks, the institutional staff and authorities from various universities worked together with the IMSS.

  7. Pius XII and the Jews: A Bibliographical Review.

    ERIC Educational Resources Information Center

    Byers, Catherine

    1978-01-01

    Presents a brief biographical sketch of Pope Pius XII and samples literary treatment of Pius's actions with respect to Nazi atrocities against the Jewish people during World War II. Concludes that Pope Pius XII failed to show moral leadership. Materials reviewed include historical texts, studies of the Vatican, documents related to the war period,…

  8. Factor XI and XII as antithrombotic targets

    PubMed Central

    Müller, Felicitas; Gailani, David; Renné, Thomas

    2015-01-01

    Purpose of review Arterial and venous thrombosis are major causes of morbidity and mortality, and the incidence of thromboembolic diseases increases as a population ages. Thrombi are formed by activated platelets and fibrin. The latter is a product of the plasma coagulation system. Currently available anticoagulants such as heparins, vitamin K antagonists and inhibitors of thrombin or factor Xa target enzymes of the coagulation cascade that are critical for fibrin formation. However, fibrin is also necessary for terminating blood loss at sites of vascular injury. As a result, anticoagulants currently in clinical use increase the risk of bleeding, partially offsetting the benefits of reduced thrombosis. This review focuses on new targets for anticoagulation that are associated with minimal or no therapy-associated increased bleeding. Recent findings Data from experimental models using mice and clinical studies of patients with hereditary deficiencies of coagulation factors XI or XII have shown that both of these clotting factors are important for thrombosis, while having minor or no apparent roles in processes that terminate blood loss (hemostasis). Summary Hereditary deficiency of factor XII (Hageman factor) or factor XI, plasma proteases that initiate the intrinsic pathway of coagulation, impairs thrombus formation and provides protection from vascular occlusive events, while having a minimal impact on hemostasis. As the factor XII–factor XI pathway contributes to thrombus formation to a greater extent than to normal hemostasis, pharmacological inhibition of these coagulation factors may offer the exciting possibility of anticoagulation therapies with minimal or no bleeding risk. PMID:21730835

  9. Processing of Factor XII during Inflammatory Reactions

    PubMed Central

    Jukema, Bernard Nico; de Maat, Steven; Maas, Coen

    2016-01-01

    The contact system was originally identified as an obsolete part of the coagulation system, but it has been repeatedly implicated in inflammatory states, such as infection, as well as in allergic- and chronic inflammatory disease. Under these conditions, there is surprisingly little evidence that factor XII (FXII) acts as a coagulation factor, and its activity appears to be mainly directed toward activation of the kallikrein–kinin system. The contact system factors interact with pathogens as well as cells of the (innate) immune system on several levels. Among others, these cells may provide negatively charged surfaces that contribute to contact activation as well as release enzymes that feed into this system. Furthermore, cellular receptors have been identified that bind contact factors at sites of inflammation. Based on the accumulated evidence, we propose a model for enzymatic crosstalk between inflammatory cells and the plasma contact system. During these reactions, FXII is enzymatically cleaved by non-contact system enzymes. This generates unactivated FXII fragments that can subsequently be rapidly activated in the fluid phase. The resulting enzyme lacks procoagulant properties, but retains its pro-inflammatory characteristic as a prekallikrein activator. PMID:27867935

  10. Atomic data for astrophysics: Ni XII

    NASA Astrophysics Data System (ADS)

    Del Zanna, G.; Badnell, N. R.

    2016-01-01

    We present new large-scale R-matrix (up to n = 4) scattering calculations for the electron collisional excitation of Cl-like Ni xii. We used the intermediate-coupling frame transformation method. We compare predicted and observed line intensities using laboratory and solar spectra, finding good agreement for all the main soft X-ray lines. With the exception of the three strongest transitions, large discrepancies with previous estimates are found, especially for the decays from the lowest 3s2 3p4 3d levels. This includes the forbidden UV lines. The atomic data for the n = 4 levels are the first to be calculated. We revise previous experimental energies, and suggest several new identifications. We point out the uncertainty in the wavelength of the 3s2 3p52P1/2-3s2 3p4 3d 2D3/2 transition, which is important for density diagnostics. The full dataset is available at our APAP website (http://www.apapnetwork.org) and at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/585/A118

  11. New atomic data for the FeXII coronal ion

    NASA Astrophysics Data System (ADS)

    Binello, A. M.; Mason, H. E.; Storey, P. J.

    1997-01-01

    Various FeXII spectroscopic lines in the UV and EUV range have been proved to be ideal diagnostic tools for measuring electron temperature, density and iron abundance in the solar corona. In the framework of the ``IRON PROJECT'' we have provided improved theoretical calculations of the atomic data required to analyse the intensity of these lines and to apply the results to SOHO (Solar Heliospheric Observatory) observations. Extensive configuration interaction and relativistic effects have been allowed for in the atomic structure computations which have provided energy levels and an extensive set of radiative data. The e-FeXII collisional problem has been tackled with the multichannel R-matrix method, a close-coupling calculation for the determination of electron impact collision strengths. Final results are presented for FeXII thermally averaged collision strengths, for fine-structure forbidden transitions within the ground configuration.

  12. High Spatial Resolution Fe XII Observations of Solar Active Regions

    NASA Astrophysics Data System (ADS)

    Testa, Paola; De Pontieu, Bart; Hansteen, Viggo

    2016-08-01

    We use UV spectral observations of active regions with the Interface Region Imaging Spectrograph (IRIS) to investigate the properties of the coronal Fe xii 1349.4 Å emission at unprecedented high spatial resolution (˜0.33″). We find that by using appropriate observational strategies (i.e., long exposures, lossless compression), Fe xii emission can be studied with IRIS at high spatial and spectral resolution, at least for high-density plasma (e.g., post-flare loops and active region moss). We find that upper transition region (TR; moss) Fe xii emission shows very small average Doppler redshifts ({v}{{D}} ˜ 3 km s-1) as well as modest non-thermal velocities (with an average of ˜24 km s-1 and the peak of the distribution at ˜15 km s-1). The observed distribution of Doppler shifts appears to be compatible with advanced three-dimensional radiative MHD simulations in which impulsive heating is concentrated at the TR footpoints of a hot corona. While the non-thermal broadening of Fe xii 1349.4 Å peaks at similar values as lower resolution simultaneous Hinode Extreme Ultraviolet Imaging Spectrometer (EIS) measurements of Fe xii 195 Å, IRIS observations show a previously undetected tail of increased non-thermal broadening that might be suggestive of the presence of subarcsecond heating events. We find that IRIS and EIS non-thermal line broadening measurements are affected by instrumental effects that can only be removed through careful analysis. Our results also reveal an unexplained discrepancy between observed 195.1/1349.4 Å Fe xii intensity ratios and those predicted by the CHIANTI atomic database.

  13. 76 FR 75563 - Notice for Delay of Payment of Title XII Interest for Three States

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-02

    ... Employment and Training Administration Notice for Delay of Payment of Title XII Interest for Three States... approval for delay of Title XII interest payment for three states. Section 1202(b)(3)(B) of the Social Security Act permits a state to delay payment of interest accrued on Title XII advances made during...

  14. Development and characterization of new monoclonal antibodies against human recombinant CA XII.

    PubMed

    Dekaminaviciute, Dovile; Lasickiene, Rita; Parkkila, Seppo; Jogaite, Vaida; Matuliene, Jurgita; Matulis, Daumantas; Zvirbliene, Aurelija

    2014-01-01

    Carbonic anhydrases (CAs) are enzymes that catalyse the reversible hydration of CO2 to bicarbonate. CA XII is considered a potential biomarker of tumor cells and a promising target for specific therapies. The aim of the current study was to develop new monoclonal antibodies (MAbs) against human recombinant CA XII and evaluate their diagnostic potential. An extracellular catalytic domain of human CA XII was expressed in E. coli and used as an immunogen. Seven stable hybridoma cell lines producing high-affinity IgG antibodies against human CA XII were generated. The majority of MAbs were highly specific to CA XII and did not cross-react with human recombinant CA I, CA II, CA VII, and CA XIII. In order to demonstrate the diagnostic value of the MAbs, they were employed for the immunohistochemistry analysis of CA XII expression in tissues. Two MAbs (15A4 and 4A6) demonstrated a strong and specific immunostaining of CA XII in human tissue specimens. Flow cytometry analysis of 5 human tumor cell lines with the MAb 15A4 revealed its immunoreactivity with cellular CA XII. In conclusion, the MAbs raised against recombinant catalytic domain of CA XII recognize cellular CA XII and represent a promising diagnostic tool for the immunodetection of CA XII-expressing cells.

  15. 48 CFR 715.370-1 - Title XII selection procedure-general.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Title XII selection procedure-general. 715.370-1 Section 715.370-1 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Source Selection 715.370-1 Title XII selection procedure—general....

  16. 78 FR 79363 - Hazardous Materials: Adoption of ASME Code Section XII and the National Board Inspection Code

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-30

    ... Hazardous Materials: Adoption of ASME Code Section XII and the National Board Inspection Code AGENCY... Code, Section XII (Section XII) for the design, construction, and certification of cargo tank motor... edition of the National Board of Boiler and Pressure Vessel Inspectors' National Board Inspection...

  17. Atomic data and spectral line intensities for Ar XII

    NASA Astrophysics Data System (ADS)

    Eissner, W.; Landi, E.; Bhatia, A. K.

    2005-03-01

    Electron impact collision strengths are computed for Ar XII in a distorted wave approach and energy levels, oscillator strengths, spontaneous radiative decay rates for the collision target, as well as collisional high energy limits are obtained from an atomic structure calculation. The target expansion comprises the six spectroscopic configurations 2s 22p 3, 2s2p 4, 2p 5, 2s 22p 23s, 2s 22p 23p, and 2s 22p 23d, giving rise to 72 fine-structure levels in intermediate coupling. Collision strengths are calculated at five incident energies: 35, 70, 105, 140, and 175 Ry. They are complemented by Coulomb-Born limits towards infinite collision energy for forbidden transitions and line strengths for optically allowed transitions. Excitation rate coefficients are obtained as a function of electron temperature by assuming a Maxwellian electron velocity distribution. Using the excitation rate coefficients and the radiative transition rates, statistical equilibrium equations for level populations are solved at electron densities covering the range of 10 8-10 14 cm -3 at an electron temperature of log Te/K = 6.4, corresponding to maximum abundance of Ar XII. Relative spectral line intensities are also calculated.

  18. Atomic Data and Spectral Line Intensities for Ar XII

    NASA Technical Reports Server (NTRS)

    Eissner, W.; Landi, E.; Bhatia, A. K.

    2004-01-01

    Electron impact collision strengths, energy levels, oscillator strengths and spontaneous radiative decay rates are calculated for Ar XII. The configurations used are 2s(sup 2)p(sup 3), 2s(sup 2)p(sup 4), 2p(sup 5), 2s(sup 2)2p(sup 2)3s, 2s(sup 2)2p(sup 2)3p, and 2s(sup 2)2p(sup 2)3d giving rise to 72 fine-structure levels in intermediate coupling. Collision strengths are calculated at five incident energies: 35, 70, 105, 140 and 175 Ry. They are complemented by Coulomb-Born limits towards infinite collision energy for forbidden transitions and line strengths for optically allowed transitions. Excitation rate coefficients are calculated as a function of electron temperature by assuming a Maxwellian electron velocity distribution. Using the excitation rate coefficients and the radiative transition rates, statistical equilibrium equations for level populations are solved at electron densities covering the range of 10(exp 8)-10(exp 14)/cm(exp 3) at an electron temperature of log T(sub e)/K = 6.4, corresponding to maximum abundance of AR-XII. Relative spectral line intensities are calculated.

  19. Misfolded proteins activate Factor XII in humans, leading to kallikrein formation without initiating coagulation

    PubMed Central

    Maas, Coen; Govers-Riemslag, José W.P.; Bouma, Barend; Schiks, Bettina; Hazenberg, Bouke P.C.; Lokhorst, Henk M.; Hammarström, Per; ten Cate, Hugo; de Groot, Philip G.; Bouma, Bonno N.; Gebbink, Martijn F.B.G.

    2008-01-01

    When blood is exposed to negatively charged surface materials such as glass, an enzymatic cascade known as the contact system becomes activated. This cascade is initiated by autoactivation of Factor XII and leads to both coagulation (via Factor XI) and an inflammatory response (via the kallikrein-kinin system). However, while Factor XII is important for coagulation in vitro, it is not important for physiological hemostasis, so the physiological role of the contact system remains elusive. Using patient blood samples and isolated proteins, we identified a novel class of Factor XII activators. Factor XII was activated by misfolded protein aggregates that formed by denaturation or by surface adsorption, which specifically led to the activation of the kallikrein-kinin system without inducing coagulation. Consistent with this, we found that Factor XII, but not Factor XI, was activated and kallikrein was formed in blood from patients with systemic amyloidosis, a disease marked by the accumulation and deposition of misfolded plasma proteins. These results show that the kallikrein-kinin system can be activated by Factor XII, in a process separate from the coagulation cascade, and point to a protective role for Factor XII following activation by misfolded protein aggregates. PMID:18725990

  20. Monoclonal antibodies raised against 167-180 aa sequence of human carbonic anhydrase XII inhibit its enzymatic activity.

    PubMed

    Dekaminaviciute, Dovile; Kairys, Visvaldas; Zilnyte, Milda; Petrikaite, Vilma; Jogaite, Vaida; Matuliene, Jurgita; Gudleviciene, Zivile; Vullo, Daniela; Supuran, Claudiu T; Zvirbliene, Aurelija

    2014-12-01

    Abstract Human carbonic anhydrase XII (CA XII) is a single-pass transmembrane protein with an extracellular catalytic domain. This enzyme is being recognized as a potential biomarker for different tumours. The current study was aimed to generate monoclonal antibodies (MAbs) neutralizing the enzymatic activity of CA XII. Bioinformatics analysis of CA XII structure revealed surface-exposed sequences located in a proximity of its catalytic centre. Two MAbs against the selected antigenic peptide spanning 167-180 aa sequence of CA XII were generated. The MAbs were reactive with recombinant catalytic domain of CA XII expressed either in E. coli or mammalian cells. Inhibitory activity of the MAbs was demonstrated by a stopped flow CO2 hydration assay. The study provides new data on the surface-exposed linear CA XII epitope that may serve as a target for inhibitory antibodies with a potential immunotherapeutic application.

  1. Activation of factor XII-dependent pathways in human plasma by hematin and protoporphyrin.

    PubMed Central

    Becker, C G; Wagner, M; Kaplan, A P; Silverberg, M; Grady, R W; Liem, H; Muller-Eberhard, U

    1985-01-01

    Intravenous administration of hematin is effective in the treatment of acute exacerbations of the inducible porphyrias. In the course of such treatment, coagulopathies have occurred that are characterized by prolongation of prothrombin time, partial thromboplastin time, and formation of fibrin split products. In experiments in vitro with normal human plasma, we observed that hematin and protoporphyrin activated Factor XII-dependent pathways of coagulation and fibrinolysis, and that they generated kallikrein activity. Incubation of protoporphyrin with purified Factor XII resulted in activation as measured by amidolysis of a chromogenic substrate. Neither coproporphyrin, uroporphyrin, delta-aminolevulinic acid, porphobilinogen, or bilirubin activated Factor XII-dependent pathways. Exposure of serum containing added uroporphyrin, coproporphyrin, and protoporphyrin, but not hematin, to ultraviolet light (405 nm) resulted in activation of the classical pathway of the complement system. On the other hand, exposure of plasma containing uroporphyrin or coproporphyrin to ultraviolet light did not result in activation of Factor XII-dependent pathways. PMID:4031058

  2. Expression of cancer-related carbonic anhydrases IX and XII in normal skin and skin neoplasms.

    PubMed

    Syrjänen, Leo; Luukkaala, Tiina; Leppilampi, Mari; Kallioinen, Matti; Pastorekova, Silvia; Pastorek, Jaromir; Waheed, Abdul; Sly, William S; Parkkila, Seppo; Karttunen, Tuomo

    2014-09-01

    Purpose of the study was to evaluate the presence of hypoxia-inducible, tumour-associated carbonic anhydrases IX and XII in normal skin and a series of cutaneous tumours. Human tumour samples were taken during surgical operations performed on 245 patients and were immunohistochemically stained. A histological score value was calculated for statistical analyses which were performed using SPSS for Windows, versions 17.0 and 20.0. In normal skin, the highest expression of CA IX was detected in hair follicles, sebaceous glands, and basal parts of epidermis. CA XII was detected in all epithelial components of skin. Both CA IX and CA XII expression levels were significantly different in epidermal, appendigeal, and melanocytic tumour categories. Both CA IX and XII showed the most intense immunostaining in epidermal tumours, whereas virtually all melanocytic tumours were devoid of CA IX and XII immunostaining. In premalignant lesions, CA IX expression significantly increased when the tumours progressed to more severe dysplasia forms. Both CA IX and XII are highly expressed in different epithelial components of skin. They are also highly expressed in epidermal tumours, in which CA IX expression levels also correlate with the dysplasia grade. Interestingly, both isozymes are absent in melanocytic tumours.

  3. Limb-brightening observations from the OSO-7 satellite. III - Comparison of EUV line intensities of Fe XII, Fe XI, Fe XV, Si X and S XII, Si IX and S XI with predictions

    NASA Technical Reports Server (NTRS)

    Kastner, S. O.; Mason, H. E.

    1978-01-01

    Continuing a study of heliocentric dependence of EUV emission line intensities observed by the Goddard OSO-7 spectroheliograph in 1972, the variation of lines of the ions Fe XII, Fe XI, Fe XV, Si X and S XII, Si IX and S XI is compared with the results of individual calculations for these ions, including theoretical intensities presented for Fe XII and Fe XI. Agreement is found to be good for Fe XII and reasonable for some of the lines of the other ions which in general are weaker in intensity. Several apparent anomalies are found however which may be due to unknown line components near the wavelengths observed.

  4. Selective depletion of plasma prekallikrein or coagulation factor XII inhibits thrombosis in mice without increased risk of bleeding

    PubMed Central

    Revenko, Alexey S.; Gao, Dacao; Crosby, Jeff R.; Bhattacharjee, Gourab; Zhao, Chenguang; May, Chris; Gailani, David; Monia, Brett P.

    2011-01-01

    Recent studies indicate that the plasma contact system plays an important role in thrombosis, despite being dispensable for hemostasis. For example, mice deficient in coagulation factor XII (fXII) are protected from arterial thrombosis and cerebral ischemia-reperfusion injury. We demonstrate that selective reduction of prekallikrein (PKK), another member of the contact system, using antisense oligonucleotide (ASO) technology results in an antithrombotic phenotype in mice. The effects of PKK deficiency were compared with those of fXII deficiency produced by specific ASO-mediated reduction of fXII. Mice with reduced PKK had ∼ 3-fold higher plasma levels of fXII, and reduced levels of fXIIa-serpin complexes, consistent with fXII being a substrate for activated PKK in vivo. PKK or fXII deficiency reduced thrombus formation in both arterial and venous thrombosis models, without an apparent effect on hemostasis. The amount of reduction of PKK and fXII required to produce an antithrombotic effect differed between venous and arterial models, suggesting that these factors may regulate thrombus formation by distinct mechanisms. Our results support the concept that fXII and PKK play important and perhaps nonredundant roles in pathogenic thrombus propagation, and highlight a novel, specific and safe pharmaceutical approach to target these contact system proteases. PMID:21821705

  5. Autoactivation of blood factor XII at hydrophilic and hydrophobic surfaces.

    PubMed

    Zhuo, Rui; Siedlecki, Christopher A; Vogler, Erwin A

    2006-08-01

    Contact activation of blood factor XII (FXII, Hageman factor) in neat-buffer solution is shown not to be specific for anionic hydrophilic procoagulants as proposed by the accepted biochemistry of surface activation. Rather, FXII activation in the presence of plasma proteins leads to an apparent specificity for hydrophilic surfaces that is actually due to a relative diminution of the FXII-->FXIIa reaction at hydrophobic surfaces. FXII activation in neat-buffer solution was effectively instantaneous upon contact with either hydrophilic (fully water-wettable clean glass) or hydrophobic (poorly water-wettable silanized glass) procoagulant particles, with greater FXIIa yield obtained by activation with hydrophobic procoagulants. In sharp contrast, both activation rate and yield was found to be significantly attenuated at hydrophobic surfaces in the presence of plasma proteins. Putative FXIIa produced by surface activation with both hydrophilic and hydrophobic procoagulants was shown to hydrolyze blood factor XI (FXI) to the activated form FXIa (FXIFXIIa-->FXIa) that causes FXI-deficient plasma to rapidly coagulate.

  6. Defective thrombus formation in mice lacking coagulation factor XII

    PubMed Central

    Renné, Thomas; Pozgajová, Miroslava; Grüner, Sabine; Schuh, Kai; Pauer, Hans-Ulrich; Burfeind, Peter; Gailani, David; Nieswandt, Bernhard

    2005-01-01

    Blood coagulation is thought to be initiated by plasma protease factor VIIa in complex with the membrane protein tissue factor. In contrast, coagulation factor XII (FXII)–mediated fibrin formation is not believed to play an important role for coagulation in vivo. We used FXII-deficient mice to study the contributions of FXII to thrombus formation in vivo. Intravital fluorescence microscopy and blood flow measurements in three distinct arterial beds revealed a severe defect in the formation and stabilization of platelet-rich occlusive thrombi. Although FXII-deficient mice do not experience spontaneous or excessive injury-related bleeding, they are protected against collagen- and epinephrine-induced thromboembolism. Infusion of human FXII into FXII-null mice restored injury-induced thrombus formation. These unexpected findings change the long-standing concept that the FXII-induced intrinsic coagulation pathway is not important for clotting in vivo. The results establish FXII as essential for thrombus formation, and identify FXII as a novel target for antithrombotic therapy. PMID:16009717

  7. Division XII: Commission 46: Education & Development of Astronomy

    NASA Astrophysics Data System (ADS)

    Ros, Rosa M.; Hearnshaw, John; Stavinschi, Magda; Garcia, Beatriz; Gerbaldi, Michele; Greve, Jean-Pierre De; Guinan, Edward; Haubold, Hans; Jones, Barrie; Marshall, Laurence A.; Pasachoff, Jay

    2015-08-01

    C46 is a Commission of the Executive Committee of the IAU under Division XII Union-Wide Activities. Aiming at improvement of astronomy education and research at all levels worldwide (through the various projects it initiates),maintains, develops, as well as through the dissemination of information. C46 has 332 members and it was managed by the Organizing Committee, formed by the Commission President (Rosa M. Ros, from Spain), the Vice-Presiden (John Hearnshaw, from New Zealand), the Retiring President (Magda Stavinschi, from Romania), the Vice-President of the IAU (George Miley, from Netherland) and the PG chairs: • Worldwide Development of Astronomy WWDA: John Hearnshaw • Teaching Astronomy for Development TAD: Edward Guinan and Laurence A. Marshall • International Schools for Young Astronomers ISYA; chair: Jean-Pierre de Greve • Network for Astronomy School Education NASE: Rosa M. Ros and Beatriz Garcia • Public Understanding at the times of Solar Eclipses and transit Phenomena PUTSE: Jay Pasachoff • National Liaison and Newsletter: Barrie Jones • Collaborative Programs: Hans Haubold

  8. Factors XI and XII as Targets for New Anticoagulants

    PubMed Central

    Weitz, Jeffrey I.; Fredenburgh, James C.

    2017-01-01

    Compared with vitamin K antagonists, the direct oral anticoagulants (DOACs) are simpler to administer and are associated with less intracranial bleeding. Nonetheless, even with the DOACs, bleeding still occurs and many patients with atrial fibrillation fail to receive anticoagulant thromboprophylaxis because of the fear of bleeding. Therefore, there is an urgent need for safer anticoagulants. Recent investigations into the biochemistry of hemostasis and thrombosis have identified new targets for development of novel anticoagulants. Using data from complementary sources, including epidemiological studies and investigations in various animal models, the contact pathway has emerged as a potential mediator of thrombosis that plays a minor part in hemostasis. Consequently, factor (F) XII of the contact system and FXI in the intrinsic pathway have been identified as potentially safer targets of anticoagulation than thrombin or FXa. However, further studies are needed to identify which is the better target for the appropriate indication. This review highlights the evidence for focusing on FXI and FXII and examines the novel approaches directed at these new targets. These emerging strategies should address current unmet medical needs and provide new avenues by which to improve anticoagulant therapy by reducing the risk of bleeding. PMID:28286749

  9. The lower cranial nerves: IX, X, XI, XII.

    PubMed

    Sarrazin, J-L; Toulgoat, F; Benoudiba, F

    2013-10-01

    The lower cranial nerves innervate the pharynx and larynx by the glossopharyngeal (CN IX) and vagus (CN X) (mixed) nerves, and provide motor innervation of the muscles of the neck by the accessory nerve (CN XI) and the tongue by the hypoglossal nerve (CN XII). The symptomatology provoked by an anomaly is often discrete and rarely in the forefront. As with all cranial nerves, the context and clinical examinations, in case of suspicion of impairment of the lower cranial nerves, are determinant in guiding the imaging. In fact, the impairment may be located in the brain stem, in the peribulbar cisterns, in the foramens or even in the deep spaces of the face. The clinical localization of the probable seat of the lesion helps in choosing the adapted protocol in MRI and eventually completes it with a CT-scan. In the bulb, the intra-axial pathology is dominated by brain ischemia (in particular, with Wallenberg syndrome) and multiple sclerosis. Cisternal pathology is tumoral with two tumors, schwannoma and meningioma. The occurrence is much lower than in the cochleovestibular nerves as well as the leptomeningeal nerves (infectious, inflammatory or tumoral). Finally, foramen pathology is tumoral with, outside of the usual schwannomas and meningiomas, paragangliomas. For radiologists, fairly hesitant to explore these lower cranial pairs, it is necessary to be familiar with (or relearn) the anatomy, master the exploratory technique and be aware of the diagnostic possibilities.

  10. 76 FR 11191 - Hazardous Materials: Adoption of ASME Code Section XII and the National Board Inspection Code

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-01

    ... Hazardous Materials: Adoption of ASME Code Section XII and the National Board Inspection Code AGENCY... Pressure Vessel Code, Section XII (2010 Edition) and the National Board of Boiler and Pressure Vessel Inspectors' National Board Inspection Code (2007 Edition). Further, PHMSA is extending the comment period...

  11. 75 FR 37456 - Green Retrofit Program of Title XII of the American Recovery and Reinvestment Act of 2009

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-29

    ... URBAN DEVELOPMENT Green Retrofit Program of Title XII of the American Recovery and Reinvestment Act of... to administer the Green Retrofit Program (GRP) authorized by the Recovery Act. The legislation... Lists the Following Information Title of Proposal: Green Retrofit Program of Title XII of the...

  12. Collagen XII Contributes to Epicardial and Connective Tissues in the Zebrafish Heart during Ontogenesis and Regeneration

    PubMed Central

    Marro, Jan; Pfefferli, Catherine; de Preux Charles, Anne-Sophie; Bise, Thomas

    2016-01-01

    Zebrafish heart regeneration depends on cardiac cell proliferation, epicardium activation and transient reparative tissue deposition. The contribution and the regulation of specific collagen types during the regenerative process, however, remain poorly characterized. Here, we identified that the non-fibrillar type XII collagen, which serves as a matrix-bridging component, is expressed in the epicardium of the zebrafish heart, and is boosted after cryoinjury-induced ventricular damage. During heart regeneration, an intense deposition of Collagen XII covers the outer epicardial cap and the interstitial reparative tissue. Analysis of the activated epicardium and fibroblast markers revealed a heterogeneous cellular origin of Collagen XII. Interestingly, this matrix-bridging collagen co-localized with fibrillar type I collagen and several glycoproteins in the post-injury zone, suggesting its role in tissue cohesion. Using SB431542, a selective inhibitor of the TGF-β receptor, we showed that while the inhibitor treatment did not affect the expression of collagen 12 and collagen 1a2 in the epicardium, it completely suppressed the induction of both genes in the fibrotic tissue. This suggests that distinct mechanisms might regulate collagen expression in the outer heart layer and the inner injury zone. On the basis of this study, we postulate that the TGF-β signaling pathway induces and coordinates formation of a transient collagenous network that comprises fibril-forming Collagen I and fiber-associated Collagen XII, both of which contribute to the reparative matrix of the regenerating zebrafish heart. PMID:27783651

  13. 48 CFR 715.370-2 - Title XII selection procedure-collaborative assistance.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... makes a preliminary finding that an activity: (i) Is authorized by Title XII; and (ii) Should be classed... for its proper execution. (2) Based upon this preliminary finding, the cognizant technical office... qualified to perform the proposed project; and (iii) Evaluate the list, using the evaluation...

  14. OATYC Journal, Vol. XII, Nos. 1-2, Fall 1986-Spring 1987.

    ERIC Educational Resources Information Center

    Fullen, James, Ed.

    1987-01-01

    "OATYC Journal," published by the the Ohio Association of Two-Year Colleges, is designed as a forum for the exchange of concepts, methods, and findings relevant to the two-year college classroom. Along with commentaries and letters of reaction from the readership, the two issues of Volume XII present the following: (1) "Focus:…

  15. Molecules in Focus: Collagen XII: Protecting bone and muscle integrity by organizing collagen fibrils

    PubMed Central

    Chiquet, Matthias; Birk, David E.; Bönnemann, Carsten G.; Koch, Manuel

    2014-01-01

    Collagen XII, largest member of the fibril-associated collagens with interrupted triple helix (FACIT) family, assembles from three identical α-chains encoded by the COL12A1 gene. The molecule consists of three threadlike N-terminal noncollagenous NC3 domains, joined by disulfide bonds and a short interrupted collagen triple helix towards the C-terminus. Splice variants differ considerably in size and properties: "small" collagen XIIB (220 kDa subunit) is similar to collagen XIV, whereas collagen XIIA (350 kDa) has a much larger NC3 domain carrying glycosaminoglycan chains. Collagen XII binds to collagen I-containing fibrils via its collagenous domain, whereas its large noncollagenous arms interact with other matrix proteins such as tenascin-X. In dense connective tissues and bone, collagen XII is thought to regulate organization and mechanical properties of collagen fibril bundles. Accordingly, recent findings show that collagen XII mutations cause Ehlers-Danlos/myopathy overlap syndrome associated with skeletal abnormalities and muscle weakness in mice and humans. PMID:24801612

  16. Isatin-pyrazole benzenesulfonamide hybrids potently inhibit tumor-associated carbonic anhydrase isoforms IX and XII.

    PubMed

    Ibrahim, Hany S; Abou-Seri, Sahar M; Tanc, Muhammet; Elaasser, Mahmoud M; Abdel-Aziz, Hatem A; Supuran, Claudiu T

    2015-10-20

    New series of benzenesulfonamide derivatives incorporating pyrazole and isatin moieties were prepared using celecoxib as lead molecule. Biological evaluation of the target compounds was performed against the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1) and more precisely against the human isoforms hCA I, II (cytosolic), IX and XII (transmembrane, tumor-associated enzymes). Most of the tested compounds efficiently inhibited hCA I, II and IX, with KIs of 2.5-102 nM, being more effective than the reference drug acetazolamide. Compounds 11e, 11f, 16e and 16f were found to inhibit hCA XII with Ki of 3.7, 6.5, 5.4 and 7.2 nM, respectively. Compounds 11e and 16e, with 5-NO2 substitution on the isatin ring, were found to be selective inhibitors of hCA IX and hCA XII. Docking studies revealed that the NO2 group of both compounds participate in interactions with Asp132 within the hCA IX active site, and with residues Lys67 and Asp130 in hCA XII, respectively.

  17. Epidemiologic and clinical data linking factors XI and XII to thrombosis.

    PubMed

    Key, Nigel S

    2014-12-05

    Currently available evidence supports the contention that elevated levels of factor XI (fXI) are associated with a greater risk of venous thromboembolism and ischemic stroke, but, less convincingly, with myocardial infarction. Conversely, reduced plasma levels of fXI seem to offer some protection from venous thromboembolism and stroke, but not myocardial infarction. Factor XI-deficient patients are at risk for certain types of bleeding, particularly posttraumatic hemorrhage on mucosal surfaces where there is a high endogenous fibrinolytic activity. In contrast, the situation with fXII in human thrombosis remains enigmatic. Deficiency of fXII is clearly not associated with any bleeding risk, but neither does it seem to be protective against thrombosis. The longstanding debate as to whether partial fXII deficiency represents a risk factor for thrombosis remains unresolved, with seemingly conflicting results depending on study design, type of assay used, and analyte evaluated. The possibility that elevated fXII levels represent a risk factor for thrombosis is not borne out in the literature.

  18. Carbonic anhydrase enzymes II, VII, IX and XII in colorectal carcinomas

    PubMed Central

    Viikilä, Pia; Kivelä, Antti J; Mustonen, Harri; Koskensalo, Selja; Waheed, Abdul; Sly, William S; Pastorek, Jaromir; Pastorekova, Silvia; Parkkila, Seppo; Haglund, Caj

    2016-01-01

    AIM To investigate expression of four alpha-carbonic anhydrases (CAs) in colorectal carcinomas (CRC) and compare the results with patients’ survival. METHODS Colorectal carcinoma samples from 539 CRC patients and control tissues were arranged as tissue microarrays and analyzed with antibodies against CA II, CA VII, CA IX, and CA XII. Intensity and extent of staining were both scored from 0 to 3 in each sample. These enzyme expression levels were then correlated to patients’ survival and clinicopathological parameters, which were tumor differentiation grade and stage, site of tumor, patients’ age, and gender. Kaplan-Meier analysis and Cox regression hazard ratio model were used to analyze survival data. RESULTS CA II and CA XII staining intensities correlated with patients’ survival in that higher expression indicated poorer prognosis. In Cox regression analysis one unit increase in the CA II intensity increased the hazard ratio to 1.19 fold (CI: 1.04-1.37, P = 0.009). A significant correlation was also found when comparing CA XII staining intensity with survival of CRC patients (HR = 1.18, 95%CI: 1.01-1.38, P = 0.036). The extent of CA XII immunostaining did not correlate to the patients’ survival (P = 0.242, Kaplan-Meier analysis). A significant interaction between age group and extent of the CA II staining was found. Increased extent of CA II had a significant hazard ratio among patients 65 years and older (1.42, 95%CI: 1.16-1.73, P = 0.0006). No correlations were found between CA VII (intensity P = 0.566, extent P = 0.495, Kaplan-Meier analysis), or CA IX (intensity P = 0.879, extent P = 0.315, Kaplan-Meier analysis) immunostaining results and survival, or the other parameters. CONCLUSION The present findings indicate that CA II and CA XII could be useful in predicting survival in CRC. PMID:27688658

  19. RA-XII inhibits tumour growth and metastasis in breast tumour-bearing mice via reducing cell adhesion and invasion and promoting matrix degradation

    PubMed Central

    Leung, Hoi-Wing; Zhao, Si-Meng; Yue, Grace Gar-Lee; Lee, Julia Kin-Ming; Fung, Kwok-Pui; Leung, Ping-Chung; Tan, Ning-Hua; Lau, Clara Bik-San

    2015-01-01

    Cancer cells acquire invasive ability to degrade and adhere to extracellular matrix (ECM) and migrate to adjacent tissues. This ultimately results metastasis. Hence, the present study investigated the in vitro effects of cyclopeptide glycoside, RA-XII on cell adhesion, invasion, proliferation and matrix degradation, and its underlying mechanism in murine breast tumour cells, 4T1. The effect of RA-XII on tumour growth and metastasis in 4T1-bearing mice was also investigated. Our results showed that RA-XII inhibited tumour cell adhesion to collagen, fibronectin and laminin, RA-XII also reduced the expressions of vascular cell adhesion molecule, intracellular adhesion molecule and integrins, and integrin binding. In addition, RA-XII significantly inhibited breast tumour cell migration via interfering cofilin signaling and chemokine receptors. The activities of matrix metalloproteinase-9 and urokinase-type of plasminogen activator, and the expressions of ECM-associated proteinases were attenuated significantly by RA-XII. Furthermore, RA-XII induced G1 phase arrest and inhibited the expressions of cyclins and cyclin-dependent kinases. RA-XII inhibited the expressions of molecules in PI3K/AKT, NF-kappaB, FAK/pSRC, MAPK and EGFR signaling. RA-XII was also shown to have anti-tumour, anti-angiogenic and anti-metastatic activities in metastatic breast tumour-bearing mice. These findings strongly suggested that RA-XII is a potential anti-metastatic agent for breast cancer. PMID:26592552

  20. Inhibition of carbonic anhydrase isoforms I, II, IX and XII with secondary sulfonamides incorporating benzothiazole scaffolds.

    PubMed

    Petrou, Anthi; Geronikaki, Athina; Terzi, Emine; Guler, Ozen Ozensoy; Tuccinardi, Tiziano; Supuran, Claudiu T

    2016-12-01

    Carbonic anhydrases (CAs, EC 4.2.1.1) catalyze the fundamental reaction of CO2 hydration in all living organisms, being actively involved in the regulation of a plethora of patho/physiological conditions. A series of benzothiazole-based sulfonamides were synthesized and tested as possible CA inhibitors. Their inhibitory activity was assessed against the cytosolic human isoforms hCA I and hCA II and the transmembrane hCA IX and hCA XII. Several of the investigated derivatives showed interesting inhibition activity and selectivities for inhibiting hCA IX and hCA XII over the off-target ones hCA I and hCA II. Furthermore, computational procedures were used to investigate the binding mode of this class of compounds, within the active site of hCA IX.

  1. LIMITS ON THE EMISSION FROM FE VIII-XII IN THE HOT LOCAL INTERSTELLAR MEDIUM.

    SciTech Connect

    Bloch, J. J.; Roussel-Dupre, D.; Theiler, J. P.; Johnson, E. M.

    2001-01-01

    The majority of the emitted power from an optically thin million degree plasma (such as the one thought to produce the soft xray background) originates in the EUV band at wavelengths longer than 170 degrees A. Lines from Fe VIII - Fe XII dominate the emission in this wavelength region. This paper describes work in progress on the analysis of three years of data from the ALEXIS mission in search of this flux.

  2. 5-Aryl-1H-pyrazole-3-carboxylic acids as selective inhibitors of human carbonic anhydrases IX and XII.

    PubMed

    Cvijetić, Ilija N; Tanç, Muhammet; Juranić, Ivan O; Verbić, Tatjana Ž; Supuran, Claudiu T; Drakulić, Branko J

    2015-08-01

    Inhibitory activity of a congeneric set of 23 phenyl-substituted 5-phenyl-pyrazole-3-carboxylic acids toward human carbonic anhydrase (hCA, EC 4.2.1.1) isoforms I, II, IX and XII was evaluated by a stopped-flow CO2 hydrase assay. These compounds exerted a clear, selective inhibition of hCA IX and XII over hCAI and II, with Ki in two to one digit micromolar concentrations (4-50 μM). Derivatives bearing bulkier substituents in para-position of the phenyl ring inhibited hCA XII at one-digit micromolar concentrations, while derivatives having alkyl substituents in both ortho- and meta-positions inhibited hCA IX with Kis ranging between 5 and 25 μM. Results of docking experiments offered a rational explanation on the selectivity of these compounds toward CA IX and XII, as well as on the substitution patterns leading to best CA IX or CA XII inhibitors. By examining the active sites of these four isoforms with GRID generated molecular-interaction fields, striking differences between hCA XII and the other three isoforms were observed. The field of hydrophobic probe (DRY) appeared significantly different in CA XII active site, comparing to other three isoforms studied. To the best of our knowledge such an observation was not reported in literature so far. Considering the selectivity of these carboxylates towards membrane-associated over cytosolic CA isoforms, the title compounds could be useful for the development of isoform-specific non-sulfonamide CA inhibitors.

  3. Annexins V and XII alter the properties of planar lipid bilayers seen by conductance probes.

    PubMed

    Sokolov, Y; Mailliard, W S; Tranngo, N; Isas, M; Luecke, H; Haigler, H T; Hall, J E

    2000-05-01

    Annexins are proteins that bind lipids in the presence of calcium. Though multiple functions have been proposed for annexins, there is no general agreement on what annexins do or how they do it. We have used the well-studied conductance probes nonactin, alamethicin, and tetraphenylborate to investigate how annexins alter the functional properties of planar lipid bilayers. We found that annexin XII reduces the nonactin-induced conductance to approximately 30% of its original value. Both negative lipid and approximately 30 microM Ca(2+) are required for the conductance reduction. The mutant annexin XIIs, E105K and E105K/K68A, do not reduce the nonactin conductance even though both bind to the membrane just as wild-type does. Thus, subtle changes in the interaction of annexins with the membrane seem to be important. Annexin V also reduces nonactin conductance in nearly the same manner as annexin XII. Pronase in the absence of annexin had no effect on the nonactin conductance. But when added to the side of the bilayer opposite that to which annexin was added, pronase increased the nonactin-induced conductance toward its pre-annexin value. Annexins also dramatically alter the conductance induced by a radically different probe, alamethicin. When added to the same side of the bilayer as alamethicin, annexin has virtually no effect, but when added trans to the alamethicin, annexin dramatically reduces the asymmetry of the I-V curve and greatly slows the kinetics of one branch of the curve without altering those of the other. Annexin also reduces the rate at which the hydrophobic anion, tetraphenylborate, crosses the bilayer. These results suggest that annexin greatly reduces the ability of small molecules to cross the membrane without altering the surface potential and that at least some fraction of the active annexin is accessible to pronase digestion from the opposite side of the membrane.

  4. Fe XII STALKS AND THE ORIGIN OF THE AXIAL FIELD IN FILAMENT CHANNELS

    SciTech Connect

    Wang, Y.-M.; Sheeley, N. R. Jr.; Stenborg, G. E-mail: neil.sheeley@nrl.navy.mil

    2013-06-10

    Employing Fe XII images and line-of-sight magnetograms, we deduce the direction of the axial field in high-latitude filament channels from the orientation of the adjacent stalklike structures. Throughout the rising phase of the current solar cycle 24, filament channels poleward of latitude 30 Degree-Sign overwhelmingly obeyed the hemispheric chirality rule, being dextral (sinistral) in the northern (southern) hemisphere, corresponding to negative (positive) helicity. During the deep minimum of 2007-2009, the orientation of the Fe XII stalks was often difficult to determine, but no obvious violations of the rule were found. Although the hemispheric trend was still present during the maximum and early declining phase of cycle 23 (2000-2003), several high-latitude exceptions were identified at that time. From the observation that dextral (sinistral) filament channels form through the decay of active regions whose Fe XII features show a counterclockwise (clockwise) whorl, we conclude that the axial field direction is determined by the intrinsic helicity of the active regions. In contrast, generation of the axial field component by the photospheric differential rotation is difficult to reconcile with the observed chirality of polar crown and circular filament channels, and with the presence of filament channels along the equator. The main role of differential rotation in filament channel formation is to expedite the cancellation of flux and thus the removal of the transverse field component. We propose further that, rather than being ejected into the heliosphere, the axial field is eventually resubmerged by flux cancellation as the adjacent unipolar regions become increasingly mixed.

  5. Geothermal Program Review XII: proceedings. Geothermal Energy and the President's Climate Change Action Plan

    SciTech Connect

    Not Available

    1994-12-31

    Geothermal Program Review XII, sponsored by the Geothermal Division of US Department of Energy, was held April 25--28, 1994, in San Francisco, California. This annual conference is designed to promote effective technology transfer by bringing together DOE-sponsored researchers; utility representatives; geothermal energy developers; suppliers of geothermal goods and services; representatives from federal, state, and local agencies; and others with an interest in geothermal energy. In-depth reviews of the latest technological advancements and research results are presented during the conference with emphasis on those topics considered to have the greatest potential to impact the near-term commercial development of geothermal energy.

  6. Magnetic reconnection driven by Gekko XII lasers with a Helmholtz capacitor-coil target

    NASA Astrophysics Data System (ADS)

    Pei, X. X.; Zhong, J. Y.; Sakawa, Y.; Zhang, Z.; Zhang, K.; Wei, H. G.; Li, Y. T.; Li, Y. F.; Zhu, B. J.; Sano, T.; Hara, Y.; Kondo, S.; Fujioka, S.; Liang, G. Y.; Wang, F. L.; Zhao, G.

    2016-03-01

    We demonstrate a novel plasma device for magnetic reconnection, driven by Gekko XII lasers irradiating a double-turn Helmholtz capacitor-coil target. Optical probing revealed an accumulated plasma plume near the magnetic reconnection outflow. The background electron density and magnetic field were measured to be approximately 1018 cm-3 and 60 T by using Nomarski interferometry and the Faraday effect, respectively. In contrast with experiments on magnetic reconnection constructed by the Biermann battery effect, which produced high beta values, our beta value was much lower than one, which greatly extends the parameter regime of laser-driven magnetic reconnection and reveals its potential in astrophysical plasma applications.

  7. 40 CFR Appendix Xii to Part 266 - Nickel or Chromium-Bearing Materials that may be Processed in Exempt Nickel-Chromium Recovery...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 28 2012-07-01 2012-07-01 false Nickel or Chromium-Bearing Materials... FACILITIES Pt. 266, App. XII Appendix XII to Part 266—Nickel or Chromium-Bearing Materials that may be Processed in Exempt Nickel-Chromium Recovery Furnaces A. Exempt Nickel or Chromium-Bearing Materials...

  8. 40 CFR Appendix Xii to Part 266 - Nickel or Chromium-Bearing Materials that may be Processed in Exempt Nickel-Chromium Recovery...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 27 2014-07-01 2014-07-01 false Nickel or Chromium-Bearing Materials that may be Processed in Exempt Nickel-Chromium Recovery Furnaces XII Appendix XII to Part 266... Processed in Exempt Nickel-Chromium Recovery Furnaces A. Exempt Nickel or Chromium-Bearing Materials...

  9. Structure and function of transmembrane segment XII in osmosensor and osmoprotectant transporter ProP of Escherichia coli.

    PubMed

    Liu, Feng; Culham, Doreen E; Vernikovska, Yaroslava I; Keates, Robert A B; Boggs, Joan M; Wood, Janet M

    2007-05-15

    Escherichia coli transporter ProP acts as both an osmosensor and an osmoregulator. As medium osmolality rises, ProP is activated and mediates H+-coupled uptake of osmolytes like proline. A homology model of ProP with 12-transmembrane (TM) helices and cytoplasmic termini was created, and the protein's topology was substantiated experimentally. Residues 468-497, at the end of the C-terminal domain and linked to TM XII, form an intermolecular, homodimeric alpha-helical coiled-coil that tunes the transporter's response to osmolality. We aim to further define the structure and function of ProP residues Q415-E440, predicted to include TM XII. Each residue was replaced with cysteine (Cys) in a histidine-tagged, Cys-less ProP variant (ProP*). Cys at positions 415-418 and 438-440 were most reactive with Oregon Green Maleimide (OGM), suggesting that residues 419 through 437 are in the membrane. Except for V429-I433, reactivity of those Cys varied with helical periodicity. Cys predicted to face the interior of ProP were more reactive than Cys predicted to face the lipid. The former may be exposed to hydrated polar residues in the protein interior, particularly on the periplasmic side. Intermolecular cross-links formed when ProP* variants with Cys at positions 419, 420, 422, and 439 were treated with DTME. Thus TM XII can participate, along its entire length, in the dimer interface of ProP. Cys substitution E440C rendered ProP* inactive. All other variants retained more than 30% of the proline uptake activity of ProP* at high osmolality. Most variants with Cys substitutions in the periplasmic half of TM XII activated at lower osmolalities than ProP*. Variants with Cys substitutions on one face of the cytoplasmic half of TM XII required a higher osmolality to activate. They included elements of a GXXXG motif that are predicted to form the interface of TM XII with TM VII. These studies define the position of ProP TM XII within the membrane, further support the predicted

  10. Integrated experiments of fast ignition targets by Gekko-XII and LFEX lasers

    NASA Astrophysics Data System (ADS)

    Shiraga, H.; Fujioka, S.; Nakai, M.; Watari, T.; Nakamura, H.; Arikawa, Y.; Hosoda, H.; Nagai, T.; Koga, M.; Kikuchi, H.; Ishii, Y.; Sogo, T.; Shigemori, K.; Nishimura, H.; Zhang, Z.; Tanabe, M.; Ohira, S.; Fujii, Y.; Namimoto, T.; Sakawa, Y.; Maegawa, O.; Ozaki, T.; Tanaka, K. A.; Habara, H.; Iwawaki, T.; Shimada, K.; Nagatomo, H.; Johzaki, T.; Sunahara, A.; Murakami, M.; Sakagami, H.; Taguchi, T.; Norimatsu, T.; Homma, H.; Fujimoto, Y.; Iwamoto, A.; Miyanaga, N.; Kawanaka, J.; Jitsuno, T.; Nakata, Y.; Tsubakimoto, K.; Sueda, K.; Morio, N.; Matsuo, S.; Kawasaki, T.; Sawai, K.; Tsuji, K.; Murakami, H.; Kanabe, T.; Kondo, K.; Kodama, R.; Sarukura, N.; Shimizu, T.; Mima, K.; Azechi, H.

    2012-09-01

    Implosion and heating experiments at the Institute of Laser Engineering, Osaka University on Fast Ignition (FI) targets for the FIREX-1 project have been performed with Gekko-XII laser for implosions and LFEX laser for heating. We tried to reduce the prepulse level in the LFEX laser system and have improved the plasma diagnostics to observe the plasma in the harsh hard X-ray environment. A plastic (CD) shell target, 7-μm thick and 500 μm in diameter with a hollow gold cone was used in this experiment to guide the short-pulse laser at the time of the maximum compression. The shell target was imploded with 9 or 12 beams of Gekko-XII laser (527 nm) with energy of 300 J/beam in a 1.5 ns pulse. Two of the four LFEX laser (1053 nm) beams were injected into the inside bottom of the cone with an energy up to 0.7 kJ/beam in a 1.5 ps pulse at the time around the maximum implosion. We have observed neutron enhancement up to 3.5 × 107 with total heating energy of 300 J, which is higher than the yield obtained in the previous experiment in 2002 [R. Kodama et al. Nature 418, 933 (2002)]. We found the estimated heating efficiency is at a level of 10-20%. Fuel heating to 5 keV is expected when the full output of LFEX is used.

  11. Implosion and heating experiments of fast ignition targets by Gekko-XII and LFEX lasers

    NASA Astrophysics Data System (ADS)

    Shiraga, H.; Fujioka, S.; Nakai, M.; Watari, T.; Nakamura, H.; Arikawa, Y.; Hosoda, H.; Nagai, T.; Koga, M.; Kikuchi, H.; Ishii, Y.; Sogo, T.; Shigemori, K.; Nishimura, H.; Zhang, Z.; Tanabe, M.; Ohira, S.; Fujii, Y.; Namimoto, T.; Sakawa, Y.; Maegawa, O.; Ozaki, T.; Tanaka, K. A.; Habara, H.; Iwawaki, T.; Shimada, K.; Key, M.; Norreys, P.; Pasley, J.; Nagatomo, H.; Johzaki, T.; Sunahara, A.; Murakami, M.; Sakagami, H.; Taguchi, T.; Norimatsu, T.; Homma, H.; Fujimoto, Y.; Iwamoto, A.; Miyanaga, N.; Kawanaka, J.; Kanabe, T.; Jitsuno, T.; Nakata, Y.; Tsubakimoto, K.; Sueda, K.; Kodama, R.; Kondo, K.; Morio, N.; Matsuo, S.; Kawasaki, T.; Sawai, K.; Tsuji, K.; Murakami, H.; Sarukura, N.; Shimizu, T.; Mima, K.; Azechi, H.

    2013-11-01

    The FIREX-1 project, the goal of which is to demonstrate fuel heating up to 5 keV by fast ignition scheme, has been carried out since 2003 including construction and tuning of LFEX laser and integrated experiments. Implosion and heating experiment of Fast Ignition targets have been performed since 2009 with Gekko-XII and LFEX lasers. A deuterated polystyrene shell target was imploded with the 0.53- μm Gekko-XII, and the 1.053- μm beam of the LFEX laser was injected through a gold cone attached to the shell to generate hot electrons to heat the imploded fuel plasma. Pulse contrast ratio of the LFEX beam was significantly improved. Also a variety of plasma diagnostic instruments were developed to be compatible with harsh environment of intense hard x-rays (γ rays) and electromagnetic pulses due to the intense LFEX beam on the target. Large background signals around the DD neutron signal in time-of-flight record of neutron detector were found to consist of neutrons via (γ,n) reactions and scattered gamma rays. Enhanced neutron yield was confirmed by carefully eliminating such backgrounds. Neutron enhancement up to 3.5 × 107 was observed. Heating efficiency was estimated to be 10-20% assuming a uniform temperature rise model.

  12. Dbx1 precursor cells are a source of inspiratory XII premotoneurons

    PubMed Central

    Revill, Ann L; Vann, Nikolas C; Akins, Victoria T; Kottick, Andrew; Gray, Paul A; Del Negro, Christopher A; Funk, Gregory D

    2015-01-01

    All behaviors require coordinated activation of motoneurons from central command and premotor networks. The genetic identities of premotoneurons providing behaviorally relevant excitation to any pool of respiratory motoneurons remain unknown. Recently, we established in vitro that Dbx1-derived pre-Bötzinger complex neurons are critical for rhythm generation and that a subpopulation serves a premotor function (Wang et al., 2014). Here, we further show that a subpopulation of Dbx1-derived intermediate reticular (IRt) neurons are rhythmically active during inspiration and project to the hypoglossal (XII) nucleus that contains motoneurons important for maintaining airway patency. Laser ablation of Dbx1 IRt neurons, 57% of which are glutamatergic, decreased ipsilateral inspiratory motor output without affecting frequency. We conclude that a subset of Dbx1 IRt neurons is a source of premotor excitatory drive, contributing to the inspiratory behavior of XII motoneurons, as well as a key component of the airway control network whose dysfunction contributes to sleep apnea. DOI: http://dx.doi.org/10.7554/eLife.12301.001 PMID:26687006

  13. The polyphosphate/factor XII pathway in cancer-associated thrombosis: novel perspectives for safe anticoagulation in patients with malignancies.

    PubMed

    Nickel, Katrin F; Labberton, Linda; Long, Andrew T; Langer, Florian; Fuchs, Tobias A; Stavrou, Evi X; Butler, Lynn M; Renné, Thomas

    2016-05-01

    Cancer is an established risk factor for venous thromboembolism (VTE) and VTE is the second leading cause of death in patients with cancer. The incidence of cancer-related thrombosis is rising and is associated with worse outcomes. Despite our growing understanding on tumor-driven procoagulant mechanisms including cancer-released procoagulant proteases, expression of tissue factor on cancer cells and derived microvesicles, as well as alterations in the extracellular matrix of the cancer cell milieu, anticoagulation therapy in cancer patients has remained challenging. This review comments on a newly discovered cancer-associated procoagulant pathway. Experimental VTE models in mice and studies on patient cancer material revealed that prostate cancer cells and associated exosomes display the inorganic polymer polyphosphate on their plasma membrane. Polyphosphate activates blood coagulation factor XII and initiates thrombus formation via the intrinsic pathway of coagulation. Pharmacologic inhibition of factor XII activity protects mice from VTE and reduces thrombin coagulant activity in plasma of prostate cancer patients. Factor XII inhibitors provide thrombo-protection without impairing hemostatic mechanisms and thus, unlike currently used anticoagulants, do not increase bleeding risk. Interference with the polyphosphate/factor XII pathway may provide the novel opportunity for safe anticoagulation therapy in patients with malignancies.

  14. Simulating Univariate and Multivariate Burr Type IIII and Type XII Distributions through the Method of L-Moments

    ERIC Educational Resources Information Center

    Pant, Mohan Dev

    2011-01-01

    The Burr families (Type III and Type XII) of distributions are traditionally used in the context of statistical modeling and for simulating non-normal distributions with moment-based parameters (e.g., Skew and Kurtosis). In educational and psychological studies, the Burr families of distributions can be used to simulate extremely asymmetrical and…

  15. Characterization and Sequencing of a Genotype XII Newcastle Disease Virus Isolated from a Peacock (Pavo cristatus) in Peru

    PubMed Central

    Tataje-Lavanda, Luis; Figueroa, Aling; Segovia, Karen; Gonzalez, Rosa; Cribillero, Giovana; Montalvan, Angela; Fernández-Díaz, Manolo; Icochea, Eliana

    2015-01-01

    Here, we report the first complete sequence and biological characterization of a Newcastle disease virus (NDV) isolated from a peacock in South America (NDV/peacock/Peru/2011). This isolate, classified as genotype XII in class II, highlights the need for increased surveillance of noncommercial avian species. PMID:26227592

  16. Characterization and Sequencing of a Genotype XII Newcastle Disease Virus Isolated from a Peacock (Pavo cristatus) in Peru.

    PubMed

    Chumbe, Ana; Izquierdo-Lara, Ray; Tataje-Lavanda, Luis; Figueroa, Aling; Segovia, Karen; Gonzalez, Rosa; Cribillero, Giovana; Montalvan, Angela; Fernández-Díaz, Manolo; Icochea, Eliana

    2015-07-30

    Here, we report the first complete sequence and biological characterization of a Newcastle disease virus (NDV) isolated from a peacock in South America (NDV/peacock/Peru/2011). This isolate, classified as genotype XII in class II, highlights the need for increased surveillance of noncommercial avian species.

  17. Si XII X-ray Satellite Lines in Solar Flare Spectra

    NASA Technical Reports Server (NTRS)

    Phillips, K. J. H.; Dubau, J.; Sylwester, J.; Sylwester, B.

    2006-01-01

    The temperature dependence of the Si XII n=3 and n=4 dielectronic satellite line features at 5.82A and 5.56A respectively, near the Si XIII 1s(sup 2)-1s3p and 1s(sup 2)-1s4p lines (5.681A and 5.405A), is calculated using atomic data presented here. The resulting theoretical spectra are compared with solar flare spectra observed by the RESIK spectrometer on the CORONAS-F spacecraft. The satellites, like the more familiar n=2 satellites near the Si XIII 1s(sup 2)-1s2p lines, are formed mostly by dielectronic recombination, but unlike the n=2 satellites are unblended. The implications for similar satellite lines in flare Fe spectra are discussed.

  18. The progress in the neutron diagnostics in the Fast Ignition experiment with GEKKO XII and LFEX

    NASA Astrophysics Data System (ADS)

    Arikawa, Yasunobu; Nagai, Takahiro; Abe, Yuki; Kojima, Sadaoki; Sakata, Shohei; Inoue, Hiroaki; Fujioka, Shinsuke; Sarukura, Nobuhiko; Nakai, Mitsuo; Shiraga, Hiroyuki; Azechi, Hiroshi

    2012-10-01

    In the fast ignitor experiment the neutron diagnostics is very challenging due to too large backgrounds originated from hard X ray. In the Fast Ignition integrated experimental campaign held in 2010 in GEKKO XII and LFEX facility in Institute of Laser Engineering Osaka (ILE), the Xylen based new liquid scintillator coupled with the gated photomultiplier tube has successfully recorded neutron signal with heating the energy of up to 400 J. However there was significant large background in the signal originated from neutrons via (γ,n) reaction from the target chamber wall. The neutron collimator was developed and implemented to suppress these neutron backgrounds. We succeeded to record a very clear neutron signals in every shot in the fast ignitor experimental campaign held in July 2012 with the heating laser energy of around 1000 J with the pulse width of 2.2 ps. The details of the detector and the result of the fast ignition experiment will be presented.

  19. Inhibition of the activation of Hageman factor (factor XII) by peripheral blood cells.

    PubMed Central

    Ratnoff, O D; Emanuelson, M M; Ziats, N P

    1987-01-01

    Suspensions of peripheral blood mononuclear cells (PBMC), monocytes, T or B lymphocytes, platelets or granulocytes, and cell-depleted supernatant fluids of these suspensions inhibited activation of Hageman factor (HF, Factor XII) by ellagic acid, a property not shared by erythrocytes. PBMC also inhibited HF activation by glass or sulfatides. Contaminating platelets may have contributed to inhibition by PBMC. Elaboration of agents inhibiting HF activation required metabolically active cells. The inhibitor(s) in PBMC supernates were not identified with known agents, but had properties of a nonenzymatic protein. PBMC supernates did not contain fibrinogen, nor alter the thrombin, prothrombin, or partial thromboplastin times of normal plasma, amidolysis by activated plasma thromboplastin antecedent (Factor XIa) or activated Stuart factor (Factor Xa) or esterolysis by C1 (C1 esterase); they inhibited plasmin minimally. These experiments suggest that peripheral blood cells may impede intravascular coagulation. Whether this property helps maintain the fluidity of blood is unclear. PMID:3498741

  20. First principles study of phosphorus and boron defects in Si-XII

    NASA Astrophysics Data System (ADS)

    Malone, Brad D.; Cohen, Marvin L.

    2011-03-01

    We present a first-principles study of phosphorus and boron substitutional defects in Si-XII, a polytype of silicon in the R8 structure. Recent results from nanoindentation experiments reveal that this phase is semiconducting and has the interesting property that it can be doped n- and p-type at room temperature without an annealing step. We examine the formation energies of the B and P defects at the two distinct atomic sites in the R8 structure. We also calculate the thermodynamic transition levels of each defect in its relevant charge states. This work was supported by National Science Foundation Grant No. DMR10-1006184, the U.S. Department of Energy under Contract No. DE-AC02-05CH11231. Computational resources have been provided by the Lawrencium cluster at LBNL.

  1. The complementary roles of observation and experiment: Theodosius Dobzhansky's Genetics of Natural Populations IX and XII.

    PubMed

    Rudge, D W

    2000-01-01

    Theodosius Dobzhansky has long been recognized by historians as a pioneer in the combining of the 'field natural history' and 'laboratory experimentalist' traditions in biology (Allen 1994). The following essay analyzes two papers in his well-known Genetics of Natural Populations series, GNP IX and GNP XII, which demonstrate how Dobzhansky combined field and laboratory work in the pursuit of an evolutionary question. The analysis reveals the multiple and complementary roles field observations and experiments played in his investigations. But it also identifies several interpretive problems associated with the use of intervention that limited the effectiveness of his approach. The essay argues that these problems reflect a fundamental tension between the amount of control Dobzhansky had over the circumstances of his experiments and the applicability of his results to natural populations. It concludes that this trade-off represents an important distinction between experiments in biology and most other sciences.

  2. Unmelted Meteoritic Debris Collected from Eltanin Ejecta in Polarstern Cores from Expedition ANT XII/4

    NASA Technical Reports Server (NTRS)

    Kyte, Frank T.

    2002-01-01

    A total of 1.7g of unmelted meteorite particles have been recovered from FS Polarstern piston cores collected on expedition ANT XII/4 that contain ejecta from the Eltanin impact event. Most of the mass (1.2 g) is a large, single specimen that is a polymict breccia, similar in mineralogy and chemistry to howardites or the silicate fraction of mesosiderites. Most of the remaining mass is in several large individual pieces (20-75mg each) that are polymict breccias, fragments dominated by pyroxene, and an igneous rock fragment. The latter has highly fractionated REE, similar to those reported in mafic clasts from mesosiderites. Other types of specimens identified include fragments dominated by maskelynite or olivine. These pieces of the projectile probably survived impact by being blown off the back surface of the Eltanin asteroid during its impact into the Bellingshausen Sea.

  3. Saccharin Sulfonamides as Inhibitors of Carbonic Anhydrases I, II, VII, XII, and XIII

    PubMed Central

    Morkūnaitė, Vaida; Baranauskienė, Lina; Zubrienė, Asta; Trapencieris, Pēteris

    2014-01-01

    A series of modified saccharin sulfonamides have been designed as carbonic anhydrase (CA) inhibitors and synthesized. Their binding to CA isoforms I, II, VII, XII, and XIII was measured by the fluorescent thermal shift assay (FTSA) and isothermal titration calorimetry (ITC). Saccharin bound the CAs weakly, exhibiting the affinities of 1–10 mM for four CAs except CA I where binding could not be detected. Several sulfonamide-bearing saccharines exhibited strong affinities of 1–10 nM towards particular CA isoforms. The functional group binding Gibbs free energy additivity maps are presented which may provide insights into the design of compounds with increased affinity towards selected CAs. PMID:25276805

  4. ELECTRON-ION RECOMBINATION OF Fe XII FORMING Fe XI: LABORATORY MEASUREMENTS AND THEORETICAL CALCULATIONS

    SciTech Connect

    Novotny, O.; Hahn, M.; Lestinsky, M.; Savin, D. W.; Badnell, N. R.; Bernhardt, D.; Mueller, A.; Schippers, S.; Grieser, M.; Krantz, C.; Repnow, R.; Wolf, A.

    2012-07-01

    We have measured electron-ion recombination for Fe XII forming Fe XI using a merged-beam configuration at the heavy-ion storage ring TSR located at the Max Planck Institute for Nuclear Physics in Heidelberg, Germany. The measured merged-beam recombination rate coefficient (MBRRC) for collision energies from 0 to 1500 eV is presented. This work uses a new method for determining the absolute MBRRC based on a comparison of the ion beam decay rate with and without the electron beam on. For energies below 75 eV, the spectrum is dominated by dielectronic recombination (DR) resonances associated with 3s {yields} 3p and 3p {yields} 3d core excitations. At higher energies, we observe contributions from 3 {yields} N' and 2 {yields} N' core excitation DR. We compare our experimental results to state-of-the-art multi-configuration Breit-Pauli (MCBP) calculations and find significant differences, both in resonance energies and strengths. We have extracted the DR contributions from the measured MBRRC data and transformed them into a plasma recombination rate coefficient (PRRC) for temperatures in the range of 10{sup 3}-10{sup 7} K. We show that the previously recommended DR data for Fe XII significantly underestimate the PRRC at temperatures relevant for both photoionized plasmas (PPs) and collisionally ionized plasmas (CPs). This is contrasted with our MCBP PRRC results, which agree with the experiment to within 30% at PP temperatures and even better at CP temperatures. We find this agreement despite the disagreement shown by the detailed comparison between our MCBP and experimental MBRRC results. Last, we present a simple parameterized form of the experimentally derived PRRC for easy use in astrophysical modeling codes.

  5. Opisthorchiasis in infant remains from the medieval Zeleniy Yar burial ground of XII-XIII centuries AD.

    PubMed

    Slepchenko, Sergey Mikhailovich; Gusev, Alexander Vasilevich; Ivanov, Sergey Nikolaevich; Svyatova, Evgenia Olegovna

    2015-12-01

    We present a paleoparasitological analysis of the medieval Zeleniy Yar burial ground of the XII-XII centuries AD located in the northern part of Western Siberia. Parasite eggs, identified as eggs of Opisthorchis felineus, were found in the samples from the pelvic area of a one year old infant buried at the site. Presence of these eggs in the soil samples from the infant's abdomen suggests that he/she was infected with opisthorchiasis and imply consumption of undercooked fish. Ethnographic records collected among the population of the northern part of Western Siberia reveal numerous cases of feeding raw fish to their children. Zeleniy Yar case of opisthorchiasis suggests that this dietary custom has persisted from at least medieval times.

  6. Dynamics enhanced by HCl doping triggers full Pauling entropy release at the ice XII-XIV transition

    NASA Astrophysics Data System (ADS)

    Köster, K. W.; Fuentes-Landete, V.; Raidt, A.; Seidl, M.; Gainaru, C.; Loerting, T.; Böhmer, R.

    2015-06-01

    The pressure-temperature phase diagram of ice displays a perplexing variety of structurally distinct phases. In the century-long history of scientific research on ice, the proton-ordered ice phases numbered XIII through XV were discovered only recently. Despite considerable effort, none of the transitions leading from the low-temperature ordered ices VIII, IX, XI, XIII, XIV and XV to their high-temperature disordered counterparts were experimentally found to display the full Pauling entropy. Here we report calorimetric measurements on suitably high-pressure-treated, hydrogen chloride-doped ice XIV that demonstrate just this at the transition to ice XII. Dielectric spectroscopy on undoped and on variously doped ice XII crystals reveals that addition of hydrogen chloride, the agent triggering complete proton order in ice XIV, enhances the precursor dynamics strongest. These discoveries provide new insights into the puzzling observation that different dopants trigger the formation of different proton-ordered ice phases.

  7. Dynamics enhanced by HCl doping triggers full Pauling entropy release at the ice XII-XIV transition.

    PubMed

    Köster, K W; Fuentes-Landete, V; Raidt, A; Seidl, M; Gainaru, C; Loerting, T; Böhmer, R

    2015-06-16

    The pressure-temperature phase diagram of ice displays a perplexing variety of structurally distinct phases. In the century-long history of scientific research on ice, the proton-ordered ice phases numbered XIII through XV were discovered only recently. Despite considerable effort, none of the transitions leading from the low-temperature ordered ices VIII, IX, XI, XIII, XIV and XV to their high-temperature disordered counterparts were experimentally found to display the full Pauling entropy. Here we report calorimetric measurements on suitably high-pressure-treated, hydrogen chloride-doped ice XIV that demonstrate just this at the transition to ice XII. Dielectric spectroscopy on undoped and on variously doped ice XII crystals reveals that addition of hydrogen chloride, the agent triggering complete proton order in ice XIV, enhances the precursor dynamics strongest. These discoveries provide new insights into the puzzling observation that different dopants trigger the formation of different proton-ordered ice phases.

  8. Opisthorchiasis in infant remains from the medieval Zeleniy Yar burial ground of XII-XIII centuries AD

    PubMed Central

    Slepchenko, Sergey Mikhailovich; Gusev, Alexander Vasilevich; Ivanov, Sergey Nikolaevich; Svyatova, Evgenia Olegovna

    2015-01-01

    We present a paleoparasitological analysis of the medieval Zeleniy Yar burial ground of the XII-XII centuries AD located in the northern part of Western Siberia. Parasite eggs, identified as eggs of Opisthorchis felineus, were found in the samples from the pelvic area of a one year old infant buried at the site. Presence of these eggs in the soil samples from the infant’s abdomen suggests that he/she was infected with opisthorchiasis and imply consumption of undercooked fish. Ethnographic records collected among the population of the northern part of Western Siberia reveal numerous cases of feeding raw fish to their children. Zeleniy Yar case of opisthorchiasis suggests that this dietary custom has persisted from at least medieval times. PMID:26602874

  9. Collagen XII and XIV, new partners of cartilage oligomeric matrix protein in the skin extracellular matrix suprastructure.

    PubMed

    Agarwal, Pallavi; Zwolanek, Daniela; Keene, Douglas R; Schulz, Jan-Niklas; Blumbach, Katrin; Heinegård, Dick; Zaucke, Frank; Paulsson, Mats; Krieg, Thomas; Koch, Manuel; Eckes, Beate

    2012-06-29

    The tensile and scaffolding properties of skin rely on the complex extracellular matrix (ECM) that surrounds cells, vasculature, nerves, and adnexus structures and supports the epidermis. In the skin, collagen I fibrils are the major structural component of the dermal ECM, decorated by proteoglycans and by fibril-associated collagens with interrupted triple helices such as collagens XII and XIV. Here we show that the cartilage oligomeric matrix protein (COMP), an abundant component of cartilage ECM, is expressed in healthy human skin. COMP expression is detected in the dermal compartment of skin and in cultured fibroblasts, whereas epidermis and HaCaT cells are negative. In addition to binding collagen I, COMP binds to collagens XII and XIV via their C-terminal collagenous domains. All three proteins codistribute in a characteristic narrow zone in the superficial papillary dermis of healthy human skin. Ultrastructural analysis by immunogold labeling confirmed colocalization and further revealed the presence of COMP along with collagens XII and XIV in anchoring plaques. On the basis of these observations, we postulate that COMP functions as an adapter protein in human skin, similar to its function in cartilage ECM, by organizing collagen I fibrils into a suprastructure, mainly in the vicinity of anchoring plaques that stabilize the cohesion between the upper dermis and the basement membrane zone.

  10. PREFACE: 12th Conference on Recent Developments in Gravity (NEB XII)

    NASA Astrophysics Data System (ADS)

    Christodoulakis, Theodosios; Vagenas, Elias C.

    2007-06-01

    Continuing the 24 year old tradition, one of the Greek relativistic groups, this time the Relativity Group of the Physics Department of the University of Athens, organized the 12th Conference of the series "Recent Developments in Gravity" (NEB XII). This time NEB took place at Nafplio, Greece, from Thursday 29 June to Sunday 2 July, 2006. The Conference was attended by more than 100 participants, more than 50% of whom were relativists from abroad (both Greek and other nationalities). This signifies a tendency of the last few Conferences to open up the Greek Relativity Conference to the international scientific community. Actually, many notable members of the relativistic community all over the globe showed particular interest in coming to Nafplio, and spend four relaxed days in a nice sunny and historical place, presenting the results of their more recent work and discussing it with colleagues and students from Greece. The NEB XII Conference covered various aspects of gravitational physics: Relativistic Astrophysics, Mathematical Relativity, Quantum Gravity, and Cosmology. Although the program was rather heavy and for the first time we had parallel sessions running in the afternoons, the wonderful weather (apart from the last afternoon when it rained heavily) and the beauty of Nafplio helped the organizers offer the participants a warm, pleasant, and creative time. According to most attendees, their impression was more than good, not only with respect to the hospitable environment, but with respect to the high level of talks as well. We hope the next Conference, which will be organized by the Relativity Group of the Aristotle University of Thessaloniki in the summer of 2008, will raise the standards of the Conference even higher, thus further establishing our Conference as a notable Conference in the Relativistic community all over the world. Finally, we would like to thank the Gravitational Physics Section of the European Physical Society (GPS/EPS), ILIAS

  11. Factor XII: a novel target for safe prevention of thrombosis and inflammation.

    PubMed

    Kenne, E; Nickel, K F; Long, A T; Fuchs, T A; Stavrou, E X; Stahl, F R; Renné, T

    2015-12-01

    Plasma protein factor XII (FXII) activates the procoagulant and proinflammatory contact system that drives both the kallikrein-kinin system and the intrinsic pathway of coagulation. When zymogen FXII comes into contact with negatively charged surfaces, it auto-activates to the serine proteaseactivated FXII (FXIIa). Recently, various in vivo activators of FXII have been identified including heparin, misfolded protein aggregates, polyphosphate and nucleic acids. Murine models have established a central role of FXII in arterial and venous thrombosis. Despite its central function in thrombosis, deficiency in FXII does not impair haemostasis in animals and humans. In a preclinical cardiopulmonary bypass system in large animals, the FXIIa-blocking antibody 3F7 prevented thrombosis; however, in contrast to traditional anticoagulants, bleeding was not increased. In addition to its function in thrombosis, FXIIa initiates formation of the inflammatory mediator bradykinin. This mediator increases vascular leak, causes vasodilation, and induces chemotaxis with implications for septic, anaphylactic and allergic disease states. Therefore, targeting FXIIa appears to be a promising strategy for thromboprotection without associated bleeding risks but with anti-inflammatory properties.

  12. P-glycoprotein-mediated chemoresistance is reversed by carbonic anhydrase XII inhibitors

    PubMed Central

    Kopecka, Joanna; Rankin, Gregory M.; Salaroglio, Iris C.

    2016-01-01

    Carbonic anhydrase XII (CAXII) is a membrane enzyme that maintains pH homeostasis and sustains optimum P-glycoprotein (Pgp) efflux activity in cancer cells. Here, we investigated a panel of eight CAXII inhibitors (compounds 1–8), for their potential to reverse Pgp mediated tumor cell chemoresistance. Inhibitors (5 nM) were screened in human and murine cancer cells (colon, lung, breast, bone) with different expression levels of CAXII and Pgp. We identified three CAXII inhibitors (compounds 1, 2 and 4) that significantly (≥ 2 fold) increased the intracellular retention of the Pgp-substrate and chemotherapeutic doxorubicin, and restored its cytotoxic activity. The inhibitors lowered intracellular pH to indirectly impair Pgp activity. Ca12-knockout assays confirmed that the chemosensitizing property of the compounds was dependent on active CAXII. Furthermore, in a preclinical model of drug-resistant breast tumors compound 1 (1900 ng/kg) restored the efficacy of doxorubicin to the same extent as the direct Pgp inhibitor tariquidar. The expression of carbonic anhydrase IX had no effect on the intracellular doxorubicin accumulation. Our work provides strong evidence that CAXII inhibitors are effective chemosensitizer agents in CAXII-positive and Pgp-positive cancer cells. The use of CAXII inhibitors may represent a turning point in combinatorial chemotherapeutic schemes to treat multidrug-resistant tumors. PMID:27811376

  13. Nonlinear growth of Rayleigh-Taylor instability directly driven by the GEKKO-XII glass laser

    NASA Astrophysics Data System (ADS)

    Nagaya, T.; Shigemori, K.; Azechi, H.; Nakai, M.; Nagatomo, H.; Takabe, H.; Mima, K.; Nishiguchi, A.

    1997-11-01

    We are investigating the nonlinear growth of the Rayleigh-Taylor (RT) instability in planar targets direct-driven by the GEKKO-XII glass laser. Initially-rippled polystyrene foils with 16- and 25-μm thickness were irradiated uniformity by partially coherent light (PCL) of a 0.53-μm laser wavelength. The wavelengths of perturbations were 100 and 60 μm, and the amplitudes were 5 and 3 μm. The intensity of PCL was 0.7 x 10^13W/cm^2. Both the areal density and the spatial shape of the perturbations were measured with the x-ray streak and the x-ray framing camera, respectively. The bubble-spike structure were oberved by the images with the x-ray framing camera. The spike finally became very thin sheet with thickness about 1/10 of the bubble size. No mashroom structure was observed at this laser intensity. Data are Fourier analyzed and the evolution of the higher harmonics in perturbations are obtained. We will compare the experimental results with the 2D hydrodynamic simulation, ILESTA-2D.

  14. Inhibition of the activation of Hageman factor (factor XII) by platelet factor 4.

    PubMed

    Dumenco, L L; Everson, B; Culp, L A; Ratnoff, O D

    1988-09-01

    Platelet factor 4 is a polypeptide constituent of platelet alpha granules that is released during platelet aggregation and inhibits heparin-mediated reactions. Hageman factor (factor XII) is a plasma proenzyme that, when activated by certain negatively charged agents, initiates clotting via the intrinsic pathway of thrombin formation. In earlier studies using crude systems, platelet factor 4 inhibited activation of Hageman factor by dextran sulfate or cerebrosides, but not activation of Hageman factor by kaolin or ellagic acid. In the present study we examined the mechanisms of inhibition by platelet factor 4, using purified reagents. Platelet factor 4 inhibited activation of Hageman factor by ellagic acid, as measured by amidolysis of a synthetic substrate of activated Hageman factor, an effect inhibited by heparin or by an anti-platelet factor 4 antiserum. Coating glass tubes with platelet factor 4 before addition of normal plasma significantly lengthened the partial thromboplastin time of normal plasma. In addition, the clot-promoting properties of kaolin were inhibited by its prior exposure to platelet factor 4. Thus, the inhibitory properties of platelet factor 4 directed against the activation of Hageman factor were confirmed in a purified system. In this purified system, in contrast to earlier studies using crude systems, platelet factor 4 inhibited activation of Hageman factor by glass, ellagic acid, or kaolin.

  15. Inhibition of the activation of Hageman factor (factor XII) by complement subcomponent C1q.

    PubMed

    Rehmus, E H; Greene, B M; Everson, B A; Ratnoff, O D

    1987-08-01

    Hageman factor (HF, Factor XII) is activated by glass, collagen, and ellagic acid, and initiates blood coagulation via the intrinsic pathway. C1q inhibits collagen-induced platelet aggregation and adherence of platelets to glass, effects attributable to the collagen-like region of C1q. We examined the actions of C1q on HF activation. Incubation of C1q with HF before addition of HF-deficient plasma extended the activated partial thromboplastin time. Similarly, when glass tubes were coated with C1q before testing, the partial thromboplastin time of normal plasma was increased. C1q reduced the activation of HF by ellagic acid, as measured by the release of p-nitroaniline from the synthetic substrate H-D-prolyl-L-phenylalanyl-L-arginine-p-nitroanilide dihydrochloride, an effect inhibited by monoclonal anti-human C1q murine IgG and by digestion of C1q by collagenase. Thus, C1q inhibits activation of HF in vitro in clot-promoting and amidolytic assays and suggests a regulatory mechanism for the inhibition of coagulation.

  16. Inhibitory action of amyloid precursor protein against human Hageman factor (factor XII).

    PubMed

    Niwano, H; Embury, P B; Greenberg, B D; Ratnoff, O D

    1995-02-01

    Amyloid precursor protein forms that contain Kunitz protease inhibitor domains are released from activated platelets, T-lymphocytes, and leukocytes and inhibit trypsin, plasmin, and activated factor XI. We investigated the effects of amyloid precursor protein isoforms on activated Hageman factor (factor XII), activated factor X (Stuart factor), and thrombin. Recombinant amyloid precursor proteins with or without the Kunitz domain, 770 and 695 amino acids, respectively, were produced in insect cells by Baculovirus expression (BAC770 and BAC695). Neither BAC695 nor BAC770 inhibited human alpha-thrombin or activated factor X. The partial thromboplastin time was prolonged by both amyloid precursor proteins, only one of which, BAC770, contains the Kunitz protease inhibitor domain. Both forms of amyloid precursor proteins inhibited ellagic acid-induced activation of Hageman factor but did not inhibit activated Hageman factor. Bismuth subgallate, which is an insoluble analog of ellagic acid, lost its ability to activate Hageman factor on being exposed to BAC770. Inhibition of ellagic acid-induced activation of Hageman factor by both forms of amyloid precursor protein was enhanced by heparin. These findings suggested that the heparin-binding domain of amyloid precursor proteins is not in the Kunitz domain. This heparin-binding domain may block the activation of Hageman factor by negatively charged agents. Thus, amyloid precursor proteins may be involved in the control of hemostasis, properties not all dependent on the Kunitz domain.

  17. Inhibition of the activation of Hageman factor (factor XII) by complement subcomponent C1q.

    PubMed Central

    Rehmus, E H; Greene, B M; Everson, B A; Ratnoff, O D

    1987-01-01

    Hageman factor (HF, Factor XII) is activated by glass, collagen, and ellagic acid, and initiates blood coagulation via the intrinsic pathway. C1q inhibits collagen-induced platelet aggregation and adherence of platelets to glass, effects attributable to the collagen-like region of C1q. We examined the actions of C1q on HF activation. Incubation of C1q with HF before addition of HF-deficient plasma extended the activated partial thromboplastin time. Similarly, when glass tubes were coated with C1q before testing, the partial thromboplastin time of normal plasma was increased. C1q reduced the activation of HF by ellagic acid, as measured by the release of p-nitroaniline from the synthetic substrate H-D-prolyl-L-phenylalanyl-L-arginine-p-nitroanilide dihydrochloride, an effect inhibited by monoclonal anti-human C1q murine IgG and by digestion of C1q by collagenase. Thus, C1q inhibits activation of HF in vitro in clot-promoting and amidolytic assays and suggests a regulatory mechanism for the inhibition of coagulation. PMID:3038961

  18. Defective glycosylation of coagulation factor XII underlies hereditary angioedema type III

    PubMed Central

    Björkqvist, Jenny; de Maat, Steven; Lewandrowski, Urs; Di Gennaro, Antonio; Oschatz, Chris; Schönig, Kai; Nöthen, Markus M.; Drouet, Christian; Braley, Hal; Nolte, Marc W.; Sickmann, Albert; Panousis, Con; Maas, Coen; Renné, Thomas

    2015-01-01

    Hereditary angioedema type III (HAEIII) is a rare inherited swelling disorder that is associated with point mutations in the gene encoding the plasma protease factor XII (FXII). Here, we demonstrate that HAEIII-associated mutant FXII, derived either from HAEIII patients or recombinantly produced, is defective in mucin-type Thr309-linked glycosylation. Loss of glycosylation led to increased contact-mediated autoactivation of zymogen FXII, resulting in excessive activation of the bradykinin-forming kallikrein-kinin pathway. In contrast, both FXII-driven coagulation and the ability of C1-esterase inhibitor to bind and inhibit activated FXII were not affected by the mutation. Intravital laser-scanning microscopy revealed that, compared with control animals, both F12–/– mice reconstituted with recombinant mutant forms of FXII and humanized HAEIII mouse models with inducible liver-specific expression of Thr309Lys-mutated FXII exhibited increased contact-driven microvascular leakage. An FXII-neutralizing antibody abolished bradykinin generation in HAEIII patient plasma and blunted edema in HAEIII mice. Together, the results of this study characterize the mechanism of HAEIII and establish FXII inhibition as a potential therapeutic strategy to interfere with excessive vascular leakage in HAEIII and potentially alleviate edema due to other causes. PMID:26193639

  19. Progress report on new antiepileptic drugs: A summary of the Twelfth Eilat Conference (EILAT XII).

    PubMed

    Bialer, Meir; Johannessen, Svein I; Levy, René H; Perucca, Emilio; Tomson, Torbjörn; White, H Steve

    2015-03-01

    The Twelfth Eilat Conference on New Antiepileptic Drugs (AEDs) - EILAT XII, took place in Madrid, Spain from August 31st to September 3rd 2014. About 130 basic scientists, clinical pharmacologists and neurologists from 22 countries attended the conference, whose main themes included "Conquering pharmacoresistant epilepsy", "Innovative emergency treatments", "Progress report on second-generation treatment" and "New methods and formulations". Consistent with previous formats of this conference, a large part of the program was devoted to a review of AEDs in development, as well as updates on AEDs introduced since 2004. Like the EILAT X and EILAT XI reports, the current article focuses on the preclinical and clinical pharmacology of AEDs that are currently in development. These include adenosine-releasing silk, allopregnanolone (SAGE-547), AMP-X-0079, brivaracetam, bumetanide, cannabidiol, cannabidivarin, 2-deoxy-glucose, everolimus, ganaxolone, huperzine A, imepitoin, minocycline, NAX 801-2, pitolisant, PRX 0023, SAGE-217, valnoctamide and its homologue sec-butyl-propylacetamide (SPD), and VLB-01. Since the previous Eilat conference, perampanel has been introduced into the market and twelve novel potential epilepsy treatments are presented for the first time.

  20. A comparison of blood factor XII autoactivation in buffer, protein cocktail, serum, and plasma solutions.

    PubMed

    Golas, Avantika; Yeh, Chyi-Huey Josh; Pitakjakpipop, Harit; Siedlecki, Christopher A; Vogler, Erwin A

    2013-01-01

    Activation of blood plasma coagulation in vitro by contact with material surfaces is demonstrably dependent on plasma-volume-to-activator-surface-area ratio. The only plausible explanation consistent with current understanding of coagulation-cascade biochemistry is that procoagulant stimulus arising from the activation complex of the intrinsic pathway is dependent on activator surface area. And yet, it is herein shown that activation of the blood zymogen factor XII (Hageman factor, FXII) dissolved in buffer, protein cocktail, heat-denatured serum, and FXI deficient plasma does not exhibit activator surface-area dependence. Instead, a highly-variable burst of procoagulant-enzyme yield is measured that exhibits no measurable kinetics, sensitivity to mixing, or solution-temperature dependence. Thus, FXII activation in both buffer and protein-containing solutions does not exhibit characteristics of a biochemical reaction but rather appears to be a "mechanochemical" reaction induced by FXII molecule interactions with hydrophilic activator particles that do not formally adsorb blood proteins from solution. Results of this study strongly suggest that activator surface-area dependence observed in contact activation of plasma coagulation does not solely arise at the FXII activation step of the intrinsic pathway.

  1. Defective glycosylation of coagulation factor XII underlies hereditary angioedema type III.

    PubMed

    Björkqvist, Jenny; de Maat, Steven; Lewandrowski, Urs; Di Gennaro, Antonio; Oschatz, Chris; Schönig, Kai; Nöthen, Markus M; Drouet, Christian; Braley, Hal; Nolte, Marc W; Sickmann, Albert; Panousis, Con; Maas, Coen; Renné, Thomas

    2015-08-03

    Hereditary angioedema type III (HAEIII) is a rare inherited swelling disorder that is associated with point mutations in the gene encoding the plasma protease factor XII (FXII). Here, we demonstrate that HAEIII-associated mutant FXII, derived either from HAEIII patients or recombinantly produced, is defective in mucin-type Thr309-linked glycosylation. Loss of glycosylation led to increased contact-mediated autoactivation of zymogen FXII, resulting in excessive activation of the bradykinin-forming kallikrein-kinin pathway. In contrast, both FXII-driven coagulation and the ability of C1-esterase inhibitor to bind and inhibit activated FXII were not affected by the mutation. Intravital laser-scanning microscopy revealed that, compared with control animals, both F12-/- mice reconstituted with recombinant mutant forms of FXII and humanized HAEIII mouse models with inducible liver-specific expression of Thr309Lys-mutated FXII exhibited increased contact-driven microvascular leakage. An FXII-neutralizing antibody abolished bradykinin generation in HAEIII patient plasma and blunted edema in HAEIII mice. Together, the results of this study characterize the mechanism of HAEIII and establish FXII inhibition as a potential therapeutic strategy to interfere with excessive vascular leakage in HAEIII and potentially alleviate edema due to other causes.

  2. Carbonic anhydrase XII is a new therapeutic target to overcome chemoresistance in cancer cells

    PubMed Central

    Jacobs, Andrea; Frei, Andreas P.; Ghigo, Dario; Wollscheid, Bernd; Riganti, Chiara

    2015-01-01

    Multidrug resistance (MDR) in cancer cells is a challenging phenomenon often associated with P-glycoprotein (Pgp) surface expression. Finding new ways to bypass Pgp-mediated MDR still remains a daunting challenge towards the successful treatment of malignant neoplasms such as colorectal cancer. We applied the Cell Surface Capture technology to chemosensitive and chemoresistant human colon cancer to explore the cell surface proteome of Pgp-expressing cells in a discovery-driven fashion. Comparative quantitative analysis of identified cell surface glycoproteins revealed carbonic anhydrase type XII (CAXII) to be up-regulated on the surface of chemoresistant cells, similarly to Pgp. In cellular models showing an acquired MDR phenotype due to the selective pressure of chemotherapy, the progressive increase of the transcription factor hypoxia-inducible factor-1 alpha was paralleled by the simultaneous up-regulation of Pgp and CAXII. CAXII and Pgp physically interacted at the cell surface. CAXII silencing or pharmacological inhibition with acetazolamide decreased the ATPase activity of Pgp by altering the optimal pH at which Pgp operated and promoted chemosensitization to Pgp substrates in MDR cells. We propose CAXII as a new secondary marker of the MDR phenotype that influences Pgp activity directly and can be used as a pharmacological target for MDR research and potential treatment. PMID:25686827

  3. Role of platelets, neutrophils, and factor XII in spontaneous venous thrombosis in mice

    PubMed Central

    Heestermans, Marco; Salloum-Asfar, Salam; Salvatori, Daniela; Laghmani, El Houari; Luken, Brenda M.; Zeerleder, Sacha S.; Spronk, Henri M. H.; Korporaal, Suzanne J.; Wagenaar, Gerry T. M.; Reitsma, Pieter H.

    2016-01-01

    Recently, platelets, neutrophils, and factor XII (FXII) have been implicated as important players in the pathophysiology of venous thrombosis. Their role became evident in mouse models in which surgical handling was used to provoke thrombosis. Inhibiting anticoagulation in mice by using small interfering RNA (siRNA) targeting Serpinc1 and Proc also results in a thrombotic phenotype, which is spontaneous (no additional triggers) and reproducibly results in clots in the large veins of the head and fibrin deposition in the liver. This thrombotic phenotype is fatal but can be fully rescued by thrombin inhibition. The mouse model was used in this study to investigate the role of platelets, neutrophils, and FXII. After administration of siRNAs targeting Serpinc1 and Proc, antibody-mediated depletion of platelets fully abrogated the clinical features as well as microscopic aspects in the head. This was corroborated by strongly reduced fibrin deposition in the liver. Whereas neutrophils were abundant in siRNA-triggered thrombotic lesions, antibody-mediated depletion of circulating Ly6G-positive neutrophils did not affect onset, severity, or thrombus morphology. In addition, absence of circulating neutrophils did not affect quantitative liver fibrin deposition. Remarkably, siRNA-mediated depletion of plasma FXII accelerated the onset of the clinical phenotype; mice were affected with more severe thrombotic lesions. To summarize, in this study, onset and severity of the thrombotic phenotype are dependent on the presence of platelets but not circulating neutrophils. Unexpectedly, FXII has a protective effect. This study challenges the proposed roles of neutrophils and FXII in venous thrombosis pathophysiology. PMID:26932804

  4. Immobilized transition metals stimulate contact activation and drive factor XII-mediated coagulation

    PubMed Central

    Mutch, N.J.; Waters, E.K.; Morrissey, J. H.

    2012-01-01

    Summary Background Upon contact with an appropriate surface, factor XII (FXII) undergoes autoactivation or cleavage by kallikrein. Zn2+ is known to facilitate binding of FXII and the cofactor, high molecular weight kininogen (HK), to anionic surfaces. Objectives To investigate whether transition metals immobilized on liposome surfaces can initiate coagulation via the contact pathway. Methods & Results Liposomes containing a metal ion-chelating lipid (DOGS-NTA) were prepared by membrane extrusion (20% DOGS-NTA, 40% phosphatidylcholine, 10% phosphatidylserine, and 30% phosphatidylethanolamine). Ni2+ immobilized on such liposomes accelerated clotting in normal, but not FXI- or FXII-deficient plasma. Results were comparable to a commercial aPTT reagent. Charging such liposomes with other transition metals revealed differences in their procoagulant capacity, with Ni2+> Cu2+> Co2+ and Zn2+. Plasma could be depleted of FXI, FXII and HK by adsorption with Ni2+-containing beads, resulting in delayed clot times. Consistent with this, FXI, FXII and HK bound to immobilized Ni2+ or Cu2+ with high affinity as determined by surface plasmon resonance. In the presence of Ni2+-bearing liposomes, Km and kcat values derived for autoactivation of FXII and prekallikrein, as well as for activation of FXII by kallikrein or prekallikrein by FXIIa, were similar to literature values in the presence of dextran sulfate. Conclusions Immobilized Ni2+ and Cu2+ bind FXII, FXI and HK with high affinity and stimulate activation of the contact pathway, driving FXII-mediated coagulation. Activation of the contact system by immobilized transition metals may have implications during pathogenic infection or in individuals exposed to high levels of pollution. PMID:22905925

  5. Proteolytic properties of single-chain factor XII: a mechanism for triggering contact activation.

    PubMed

    Ivanov, Ivan; Matafonov, Anton; Sun, Mao-Fu; Cheng, Qiufang; Dickeson, S Kent; Verhamme, Ingrid M; Emsley, Jonas; Gailani, David

    2017-03-16

    When blood is exposed to variety of artificial surfaces and biologic substances, the plasma proteins factor XII (FXII) and prekallikrein undergo reciprocal proteolytic conversion to the proteases αFXIIa and α-kallikrein by a process called contact activation. These enzymes contribute to host-defense responses including coagulation, inflammation, and fibrinolysis. The initiating event in contact activation is debated. To test the hypothesis that single-chain FXII expresses activity that could initiate contact activation, we prepared human FXII variants lacking the Arg353 cleavage site required for conversion to αFXIIa (FXII-R353A), or lacking the 3 known cleavage sites at Arg334, Arg343, and Arg353 (FXII-T, for "triple" mutant), and compared their properties to wild-type αFXIIa. In the absence of a surface, FXII-R353A and FXII-T activate prekallikrein and cleave the tripeptide S-2302, demonstrating proteolytic activity. The activity is several orders of magnitude weaker than that of αFXIIa. Polyphosphate, an inducer of contact activation, enhances PK activation by FXII-T, and facilitates FXII-T activation of FXII and FXI. In plasma, FXII-T and FXII-R353A, but not FXII lacking the active site serine residue (FXII-S544A), shortened the clotting time of FXII-deficient plasma and enhanced thrombin generation in a surface-dependent manner. The effect was not as strong as for wild-type FXII. Our results support a model for induction of contact activation in which activity intrinsic to single-chain FXII initiates αFXIIa and α-kallikrein formation on a surface. αFXIIa, with support from α-kallikrein, subsequently accelerates contact activation and is responsible for the full procoagulant activity of FXII.

  6. Polyphosphate colocalizes with factor XII on platelet-bound fibrin and augments its plasminogen activator activity

    PubMed Central

    Lionikiene, Ausra S.; Georgiev, Georgi; Klemmer, Anja; Brain, Chelsea; Kim, Paul Y.

    2016-01-01

    Activated factor XII (FXIIa) has plasminogen activator capacity but its relative contribution to fibrinolysis is considered marginal compared with urokinase and tissue plasminogen activator. Polyphosphate (polyP) is released from activated platelets and mediates FXII activation. Here, we investigate the contribution of polyP to the plasminogen activator function of αFXIIa. We show that both polyP70, of the chain length found in platelets (60-100 mer), and platelet-derived polyP significantly augment the plasminogen activation capacity of αFXIIa. PolyP70 stimulated the autoactivation of FXII and subsequent plasminogen activation, indicating that once activated, αFXIIa remains bound to polyP70. Indeed, complex formation between polyP70 and αFXIIa provides protection against autodegradation. Plasminogen activation by βFXIIa was minimal and not enhanced by polyP70, highlighting the importance of the anion binding site. PolyP70 did not modulate plasmin activity but stimulated activation of Glu and Lys forms of plasminogen by αFXIIa. Accordingly, polyP70 was found to bind to FXII, αFXIIa, and plasminogen, but not βFXIIa. Fibrin and polyP70 acted synergistically to enhance αFXIIa-mediated plasminogen activation. The plasminogen activator activity of the αFXIIa-polyP70 complex was modulated by C1 inhibitor and histidine-rich glycoprotein, but not plasminogen activator inhibitors 1 and 2. Platelet polyP and FXII were found to colocalize on the activated platelet membrane in a fibrin-dependent manner and decorated fibrin strands extending from platelet aggregates. We show that in the presence of platelet polyP and the downstream substrate fibrin, αFXIIa is a highly efficient and favorable plasminogen activator. Our data are the first to document a profibrinolytic function of platelet polyP. PMID:27694320

  7. Pathotyping and Phylogenetic Characterization of Newcastle Disease Viruses Isolated in Peru: Defining Two Novel Subgenotypes Within Genotype XII.

    PubMed

    Chumbe, Ana; Izquierdo-Lara, Ray; Tataje, Luis; Gonzalez, Rosa; Cribillero, Giovana; González, Armando E; Fernández-Díaz, Manolo; Icochea, Eliana

    2017-03-01

    Infections of poultry with virulent strains of avian paramyxovirus 1 (APMV-1), also known as Newcastle disease viruses (NDVs), cause Newcastle disease (ND). This highly contagious disease affects poultry and many other species of birds worldwide. In countries where the disease is prevalent, constant monitoring and characterization of isolates causing outbreaks are necessary. In this study, we report the results of pathogenicity testing and phylogenetic analyses of seven NDVs isolated from several regions of Peru between 2004 and 2015. Six viruses had intracerebral pathogenicity indices (ICPIs) of between 1.75 and 1.88, corresponding to a velogenic pathotype. The remaining virus had an ICPI of 0.00, corresponding to a lentogenic pathotype. These results were consistent with amino acid sequences at the fusion protein (F) cleavage site. All velogenic isolates had the polybasic amino acid sequence (112)RRQKR↓F(117) at the F cleavage site. Phylogenetic analyses of complete F gene sequences showed that all isolates are classified in class II of APMV-1. The velogenic viruses are classified in genotype XII, while the lentogenic virus is classified in genotype II, closely related to the LaSota vaccine strain. Moreover, tree topology, bootstrap values, and genetic distances observed within genotype XII resulted in the identification of novel subgenotypes XIIa (in South America) and XIIb (in China) and possibly two clades within genotype XIIa. All velogenic Peruvian viruses belonged to subgenotype XIIa. Overall, our results confirm the presence of genotype XII in Peru and suggest that it is the prevalent genotype currently circulating in our country. The phylogenetic characterization of these isolates helps to characterize the evolution of NDV and may help with the development of vaccines specific to our regional necessities.

  8. Plant nuclear shape is independently determined by the SUN-WIP-WIT2-myosin XI-i complex and CRWN1.

    PubMed

    Zhou, Xiao; Groves, Norman Reid; Meier, Iris

    2015-01-01

    Nuclei undergo dynamic shape changes during plant development, but the mechanism is unclear. In Arabidopsis, Sad1/UNC-84 (SUN) proteins, WPP domain-interacting proteins (WIPs), WPP domain-interacting tail-anchored proteins (WITs), myosin XI-i, and CROWDED NUCLEI 1 (CRWN1) have been shown to be essential for nuclear elongation in various epidermal cell types. It has been proposed that WITs serve as adaptors linking myosin XI-i to the SUN-WIP complex at the nuclear envelope (NE). Recently, an interaction between Arabidopsis SUN1 and SUN2 proteins and CRWN1, a plant analog of lamins, has been reported. Therefore, the CRWN1-SUN-WIP-WIT-myosin XI-i interaction may form a linker of the nucleoskeleton to the cytoskeleton complex. In this study, we investigate this proposed mechanism in detail for nuclei of Arabidopsis root hairs and trichomes. We show that WIT2, but not WIT1, plays an essential role in nuclear shape determination by recruiting myosin XI-i to the SUN-WIP NE bridges. Compared with SUN2, SUN1 plays a predominant role in nuclear shape. The NE localization of SUN1, SUN2, WIP1, and a truncated WIT2 does not depend on CRWN1. While crwn1 mutant nuclei are smooth, the nuclei of sun or wit mutants are invaginated, similar to the reported myosin XI-i mutant phenotype. Together, this indicates that the roles of the respective WIT and SUN paralogs have diverged in trichomes and root hairs, and that the SUN-WIP-WIT2-myosin XI-i complex and CRWN1 independently determine elongated nuclear shape. This supports a model of nuclei being shaped both by cytoplasmic forces transferred to the NE and by nucleoplasmic filaments formed under the NE.

  9. Plant nuclear shape is independently determined by the SUN-WIP-WIT2-myosin XI-i complex and CRWN1

    PubMed Central

    Zhou, Xiao; Groves, Norman Reid; Meier, Iris

    2015-01-01

    Nuclei undergo dynamic shape changes during plant development, but the mechanism is unclear. In Arabidopsis, Sad1/UNC-84 (SUN) proteins, WPP domain-interacting proteins (WIPs), WPP domain-interacting tail-anchored proteins (WITs), myosin XI-i, and CROWDED NUCLEI 1 (CRWN1) have been shown to be essential for nuclear elongation in various epidermal cell types. It has been proposed that WITs serve as adaptors linking myosin XI-i to the SUN-WIP complex at the nuclear envelope (NE). Recently, an interaction between Arabidopsis SUN1 and SUN2 proteins and CRWN1, a plant analog of lamins, has been reported. Therefore, the CRWN1-SUN-WIP-WIT-myosin XI-i interaction may form a linker of the nucleoskeleton to the cytoskeleton complex. In this study, we investigate this proposed mechanism in detail for nuclei of Arabidopsis root hairs and trichomes. We show that WIT2, but not WIT1, plays an essential role in nuclear shape determination by recruiting myosin XI-i to the SUN-WIP NE bridges. Compared with SUN2, SUN1 plays a predominant role in nuclear shape. The NE localization of SUN1, SUN2, WIP1, and a truncated WIT2 does not depend on CRWN1. While crwn1 mutant nuclei are smooth, the nuclei of sun or wit mutants are invaginated, similar to the reported myosin XI-i mutant phenotype. Together, this indicates that the roles of the respective WIT and SUN paralogs have diverged in trichomes and root hairs, and that the SUN-WIP-WIT2-myosin XI-i complex and CRWN1 independently determine elongated nuclear shape. This supports a model of nuclei being shaped both by cytoplasmic forces transferred to the NE and by nucleoplasmic filaments formed under the NE. PMID:25759303

  10. Funerary practices of the Iberomaurusian population of Taforalt (Tafoughalt, Morocco, 11-12,000 BP): the case of Grave XII.

    PubMed

    Belcastro, Maria Giovanna; Condemi, Silvana; Mariotti, Valentina

    2010-06-01

    The Iberomaurusian necropolis of Taforalt (Morocco, 11-12000 BP), excavated by Roche in the 1950s, contains 28 multiple graves. The funerary practices of the Taforalt population have been the focus of a previous work (Mariotti et al., 2009). In the absence of the excavation records of the necropolis, these funerary practices were investigated through the analysis of the contents of each grave and the distribution of intentionally modified specimens (ochre-dyeing, cut marks). Previous research has drawn particular attention to Grave XII (containing three male adults and two juveniles), where many intentionally modified specimens were identified. The present study focused specifically on the human remains recovered from Grave XII. Analysis of these remains has provided evidence of interventions, such as dismemberment and defleshing of the cadaver, and the use of ochre to colour the bones. Furthermore, the presence of lesions on two skulls suggests the possibility of intentional killing and cannibalism among the Taforalt population. This study further supports our previous impression of the complex and diversified funerary practices, characterising the social life of the Iberomaurusian population of Taforalt.

  11. Semiempirical calculation of radiative constants in the spectra of nickel-like ions Kr IX, Sr XI, Y XII, Ru XVII, Pd XIX, and Ag XX

    NASA Astrophysics Data System (ADS)

    Loginov, A. V.

    2015-03-01

    The probabilities of the electric-dipole transitions 3 d 94 p, 3 d 94 f-3 d 10, 3 d 94 s, and 3 d 94 d in the spectra of nickel-like ions Kr IX, Sr XI, Y XII, Ru XVII, Pd XIX, and Ag XX are calculated semiempirically with the use of published energy levels.

  12. 77 FR 29633 - Alta Wind VII, LLC, Alta Wind IX, LLC, Alta Wind X, LLC, Alta Wind XI, LLC, Alta Wind XII, LLC...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-18

    ... Wind VII, LLC, Alta Wind IX, LLC, Alta Wind X, LLC, Alta Wind XI, LLC, Alta Wind XII, LLC, Alta Wind XIII, LLC, Alta Wind XIV, LLC, Alta Wind XV, LLC, Alta Windpower Development, LLC, TGP Development... 385.207, Alta Wind VII, LLC, Alta Wind IX, LLC, Alta Wind X, LLC, Alta Wind XI, LLC, Alta Wind...

  13. Inhibition of carbonic anhydrase isoforms I, II, IX and XII with novel Schiff bases: identification of selective inhibitors for the tumor-associated isoforms over the cytosolic ones.

    PubMed

    Sarikaya, Busra; Ceruso, Mariangela; Carta, Fabrizio; Supuran, Claudiu T

    2014-11-01

    A series of new Schiff bases was obtained from sulfanilamide, 3-fluorosulfanilamide or 4-(2-aminoethyl)-benzenesulfonamide and aromatic/heterocyclic aldehydes incorporating both hydrophobic and hydrophilic moieties. The obtained sulfonamides were investigated as inhibitors of four physiologically relevant carbonic anhydrase (CA, EC 4.2.1.1) isoforms, the cytosolic CA I and II, as well as the transmembrane, tumor-associated CA IX and XII. Most derivatives were medium potency or weak hCA I/II inhibitors, but several of them showed nanomolar affinity for CA IX and/or XII, making them an interesting example of isoform-selective compounds. The nature of the aryl/hetaryl moiety present in the initial aldehyde was the main factor influencing potency and isoform selectivity. The best and most CA IX-selective compounds incorporated moieties such as 4-methylthiophenyl, 4-cyanophenyl-, 4-(2-pyridyl)-phenyl and the 4-aminoethylbenzenesulfonamide scaffold. The best hCA XII inhibitors, also showing selectivity for this isoform, incorporated 2-methoxy-4-nitrophenyl-, 2,3,5,6-tetrafluorophenyl and 4-(2-pyridyl)-phenyl functionalities and were also derivatives of 4-aminoethylbenzenesulfonamide. The sulfanilamide and 3-fluorosulfanilamide derived Schiff bases were less active compared to the corresponding 4-aminoethyl-benzenesulfonamide derivatives. As hCA IX/XII selective inhibition is attractive for obtaining antitumor agents/diagnostic tools with a new mechanism of action, compounds of the type described here may be considered interesting preclinical candidates.

  14. Soft x-ray amplification in lithium-like Al XI (154 /angstrom/) and Si XII (129 /angstrom/)

    SciTech Connect

    Kim, D.; Skinner, C.H.; Wouters, A.; Valeo, E.; Voorhees, D.; Suckewer, S.

    1988-03-01

    Recent experiments on soft x-ray amplification in lithium-like ions in a CO/sub 2/ laser-produced recombining plasma confined in a magnetic field are presented. The maximum gain-length products observed are GL approx. = 3 to 4 for the 154 /angstrom/, 4f-3d transition in Al XI and GL (approxreverse arrowequal/ 1 to 2 for the 129 /angstrom/, 4f-3d transition in Si XII, respectively. A one-dimensional hydrodynamic code with a collisional-radiative atomic model was used to model the plasma and the theoretical predictions of gain agree well with the observations. Descriptions of both hydrodynamic and atomic physics code are given. 36 refs., 10 figs.

  15. El Material Suplementario En Los Diccionarios Bilingues Espanol-Ingles Mas Representativos De Los Siglos XX y XXI

    ERIC Educational Resources Information Center

    Fischer Dorantes, Erica

    2010-01-01

    This work is one of the first attempts to make a detailed and comparative analysis of the supplementary material of several bilingual English-Spanish dictionaries from the 20th and 21st centuries. It examines the historical development of prefaces and appendices in the most representative bilingual English-Spanish dictionaries that have…

  16. PREFACE: XII Latin American workshop on plasma physics (17-21 September 2007, Caracas, Venezuela)

    NASA Astrophysics Data System (ADS)

    Puerta, Julio

    2008-10-01

    Some years ago a group of Latin American physicists took the initiative to consult about the viability of organizing a meeting on plasma physics for researchers and students of the region. The result was that it was not only a good idea, but a necessity in order to show and share everyone's work, and to keep updated on latest advances and technologies on plasma physics. It was decided that for new researchers as well as students of Physics, it would prove to be the best way to keep them posted on such matters. This was the birth of a series of meetings known as Latin American workshops on plasma physics that take place every two years in a different Latin American country. In Venezuela we have had the opportunity to organize two editions of this interesting and important reunion of physicists. The first of these Latin American workshops on plasma physics was held in Cambuquira (Brazil) in 1982. After organizing the first six editions of the workshop, the VII LAWPP meeting was realized in Caracas in January 1997. It was designed with a structure similar to the first edition. It developed in two stages, a first week devoted to short courses with lecturers in different fields of plasma physics and a second week for contributed and invited presentations. Participants from sixteen different countries were present, half of them from this continent and the other half from overseas, demonstrating the international character of this meeting. There have been four more editions of the workshop and once again, we have had the opportunity to organize this latest edition of the series: the XII Latin American workshop on plasma physics, which took place in Caracas, Venezuela from the 17th to the 21st of September 2007. The structure was modified, because contributed and review papers were together during the first stage, with short courses realized during the second one, called mini-courses, and given by several high level contributors such as José Boedo, Leopoldo Soto, Claude

  17. [Degree of trait anxiety in a sample of athletes of the Puerto Rican delegation to the XII Pan American Games held in Winnipeg '99].

    PubMed

    Hechavarría Gómez, Rosa M; Pabón Villafañe, Angel L; Morales Figueroa, Ilia N

    2002-03-01

    This study was conducted in an attempt to determine the degree of anxiety generated by athletes of the Puerto Rican delegation to the XII Pan American Games held in Winnipeng'99 to develop support programs that contribute to the enhancement of the athletes' mental skills and the development of sports, psychology, in particular. The sample consisted of 55 athletes that participated in the abovementioned Pan American Games. The athletes represented 16 sorts and made up 40% of the Puerto Rican athletes officially registered to participate. The Sport Competition Anxiety Test-Form A was used to detect trait anxiety during competition. An analysis of the variables was conducted utilizing t-tests to determine whether there were significant (p < or = 0.05) between the quantitative variables under study. The results indicated that the athletes of the Puerto Rican delegation that participated in the XII Pan American Games have a degree of trait anxiety that needs professional attention.

  18. Mono- and di-halogenated histamine, histidine and carnosine derivatives are potent carbonic anhydrase I, II, VII, XII and XIV activators.

    PubMed

    Saada, Mohamed-Chiheb; Vullo, Daniela; Montero, Jean-Louis; Scozzafava, Andrea; Supuran, Claudiu T; Winum, Jean-Yves

    2014-09-01

    Mono- and di-halogenated histamines, l-histidine methyl ester derivatives and carnosine derivatives incorporating chlorine, bromine and iodine were prepared and investigated as activators of five carbonic anhydrase (CA, EC 4.2.1.1) isoforms, the cytosolic hCA I, II and VII, and the transmembrane hCA XII and XIV. All of them were activated in a diverse manner by the investigated compounds, with a distinct activation profile.

  19. Rapid loss of factor XII and XI activity in ellagic acid-activated normal plasma: role of plasma inhibitors and implications for automated activated partial thromboplastin time recording.

    PubMed

    Joist, J H; Cowan, J F; Khan, M

    1977-12-01

    Rapid prolongation of the aPTT of normal plasma upon incubation with ellagic acid containing aPTT reagents was observed. The aPTT prolongation was not due to time-dependent changes in pH in the incubation mixture or loss of activity of the labile coagulation factors VIII and V but occurred as a result of rapid progressive inactivation of ellagic acid-activated factors XII and XI. Prolongation of the aPTT and loss of contact factor activities was not observed in plasma incubated with particulate activator reagents. This finding seemed to indicate that adsorption of factors XII and XI to larger particles during the activation process might protect these factors from inactivation by naturally occurring plasma inhibitors. Evidence is presented which supports previous findings that C1-INH, alpha1-AT, and antithrombin (in the presence of heparin) contribute to factor XIIa and XI a inactivation in ellagic acid-activated plasma and that plasma albumin may compete with factor XII for ellagic acid binding. The data indicate that ellagic acid-containing aPTT reagents have unfavorable properties which seriously limit their usefulness in the clinical laboratory, particularly in respect to recording of the aPTT with certain fully automated clot timers.

  20. Open saccharin-based secondary sulfonamides as potent and selective inhibitors of cancer-related carbonic anhydrase IX and XII isoforms.

    PubMed

    D'Ascenzio, Melissa; Guglielmi, Paolo; Carradori, Simone; Secci, Daniela; Florio, Rosalba; Mollica, Adriano; Ceruso, Mariangela; Akdemir, Atilla; Sobolev, Anatoly P; Supuran, Claudiu T

    2017-12-01

    A large number of novel secondary sulfonamides based on the open saccharin scaffold were synthesized and evaluated as selective inhibitors of four different isoforms of human carbonic anhydrase (hCA I, II, IX and XII, EC 4.2.1.1). They were obtained by reductive ring opening of the newly synthesized N-alkylated saccharin derivatives and were shown to be inactive against the two cytosolic off-target hCA I and II (Kis > 10 µM). Interestingly, these compounds inhibited hCA IX in the low nanomolar range with Kis ranging between 20 and 298 nM and were extremely potent inhibitors of hCA XII isoenzyme (Kis ranging between 4.3 and 432 nM). Since hCA IX and XII are the cancer-related isoforms recently validated as drug targets, these results represent an important goal in the development of new anticancer candidates. Finally, a computational approach has been performed to better correlate the biological data to the binding mode of these inhibitors.

  1. Dirac R-matrix calculations of photoionization cross sections of Ni XII and atomic structure data of Ni XIII

    NASA Astrophysics Data System (ADS)

    Nazir, R. T.; Bari, M. A.; Bilal, M.; Sardar, S.; Nasim, M. H.; Salahuddin, M.

    2017-02-01

    We performed R-matrix calculations for photoionization cross sections of the two ground state configuration 3s23p5 (^2P^o3/2,1/2) levels and 12 excited states of Ni XII using relativistic Dirac Atomic R-matrix Codes (DARC) across the photon energy range between the ionizations thresholds of the corresponding states and well above the thresholds of the last level of the Ni XIII target ion. Generally, a good agreement is obtained between our results and the earlier theoretical photoionization cross sections. Moreover, we have used two independent fully relativistic GRASP and FAC codes to calculate fine-structure energy levels, wavelengths, oscillator strengths, transitions rates among the lowest 48 levels belonging to the configuration (3s23p4, 3s3p5, 3p6, 3s23p33d) in Ni XIII. Additionally, radiative lifetimes of all the excited states of Ni XIII are presented. Our results of the atomic structure of Ni XIII show good agreement with other theoretical and experimental results available in the literature. A good agreement is found between our calculated lifetimes and the experimental ones. Our present results are useful for plasma diagnostic of fusion and astrophysical plasmas.

  2. Moderation of prekallkrein-factor XII interactions in surface activation of coagulation by protein-adsorption competition.

    PubMed

    Chatterjee, Kaushik; Thornton, Jennifer L; Bauer, James W; Vogler, Erwin A; Siedlecki, Christopher A

    2009-10-01

    Traditional biochemistry of contact activation of blood coagulation suggesting that anionic hydrophilic surfaces are specific activators of the cascade is inconsistent with known trends in protein adsorption. To investigate contact activation reactions, a chromogenic assay was used to measure prekallkrein (PK) hydrolysis to kallikrein (Kal) by activated factor XII (FXIIa) at test hydrophilic (clean glass) and hydrophobic (silanized glass) surfaces in the presence of bovine serum albumin (BSA). Hydrolysis of PK by FXIIa is detected after contact of the zymogen FXII with a test hydrophobic surface only if putatively-adsorbed FXIIa is competitively displaced by BSA. By contrast, FXIIa activity is detected spontaneously following FXII activation by a hydrophilic surface and requires no adsorption displacement. These results (i) show that an anionic hydrophilic surface is not a necessary cofactor for FXIIa-mediated hydrolysis of PK, (ii) indicate that PK hydrolysis does not need to occur by an activation complex assembled directly on an anionic, activating surface, (iii) confirms that contact activation of FXII (autoactivation) is not specific to anionic hydrophilic surfaces, and (iv) demonstrates that protein-adsorption competition is an essential feature that must be included in any comprehensive mechanism of surface-induced blood coagulation.

  3. Activation of the factor XII-driven contact system in Alzheimer’s disease patient and mouse model plasma

    PubMed Central

    Zamolodchikov, Daria; Chen, Zu-Lin; Conti, Brooke A.; Renné, Thomas; Strickland, Sidney

    2015-01-01

    Alzheimer’s disease (AD) is characterized by accumulation of the β-amyloid peptide (Aβ), which likely contributes to disease via multiple mechanisms. Increasing evidence implicates inflammation in AD, the origins of which are not completely understood. We investigated whether circulating Aβ could initiate inflammation in AD via the plasma contact activation system. This proteolytic cascade is triggered by the activation of the plasma protein factor XII (FXII) and leads to kallikrein-mediated cleavage of high molecular-weight kininogen (HK) and release of proinflammatory bradykinin. Aβ has been shown to promote FXII-dependent cleavage of HK in vitro. In addition, increased cleavage of HK has been found in the cerebrospinal fluid of patients with AD. Here, we show increased activation of FXII, kallikrein activity, and HK cleavage in AD patient plasma. Increased contact system activation is also observed in AD mouse model plasma and in plasma from wild-type mice i.v. injected with Aβ42. Our results demonstrate that Aβ42-mediated contact system activation can occur in the AD circulation and suggest new pathogenic mechanisms, diagnostic tests, and therapies for AD. PMID:25775543

  4. Inhibition of the activation of Hageman factor (factor XII) and of platelet aggregation by extracts of Brugia malayi microfilariae.

    PubMed

    Foster, C B; Flanigan, T P; Kazura, J W; Dumenco, L L; Ratnoff, O D

    1991-05-01

    In human filariasis, large numbers of blood-borne microfilariae circulate unimpeded through the blood stream. How intravascular filarial parasites avoid precipitating thrombosis has not been studied in detail. We hypothesized that extracts of Brugia malayi microfilariae would contain factors that inhibit activation of hemostatic mechanisms. Initial studies demonstrated an inhibitor specific for the intrinsic coagulation cascade. The addition of microfilarial extracts to human plasma prolonged the activated partial thromboplastin time in a dose-dependent fashion but did not prolong the prothrombin, thrombin, or Russell's viper venom times. Microfilarial extracts (0.1 mg/ml) completely inhibited activation of Hageman factor (factor XII, at 0.05 U/ml) as measured in an amidolytic assay. Hageman factor previously activated by ellagic acid (factor XIIa) retained full enzymatic activity in the presence of microfilarial extract (0.1 mg/ml). The presence of inhibitory activity in the culture medium of live parasites raises the possibility that microfilariae secrete an inhibitory protein into their local environment. Microfilarial extracts at a final concentration of 0.1 mg/ml also inhibited collagen- and adenosine diphosphate-induced platelet aggregation. Arachidonic acid-induced platelet aggregation was inhibited by microfilarial extracts at a final concentration of 0.6 mg/ml. These results suggest that microfilariae of Brugia malayi, a human filarial parasite, may avoid initiating thrombosis through inhibition of the intrinsic coagulation pathway and platelet aggregation.

  5. Factor XII: What Does It Contribute To Our Understanding Of The Physiology and Pathophysiology of Hemostasis & Thrombosis

    PubMed Central

    Stavrou, Evi; Schmaier, Alvin H.

    2010-01-01

    Factor XII (FXII) is a coagulation protein that is essential for surface-activated blood coagulation tests but whose deficiency is not associated with bleeding. For over forty years, investigators in hemostasis have not considered FXII important because its deficiency is not associated with bleeding. It is because there is a dichotomy between abnormal laboratory assay findings due to FXII deficiency and clinical hemostasis that investigators sought explanations for physiologic hemostasis independent of FXII. FXII is a multidomain protein that contains two fibronectin binding consensual sequences, two epidermal growth factor regions, a kringle region, a proline-rich domain, and a catalytic domain that when proteolyzed turns into a plasma serine protease. Recent investigations with FXII deleted mice that are protected from thrombosis indicate that it contributes to the extent of developing thrombus in the intravascular compartment. These findings suggest that it has a role in thrombus formation without influencing hemostasis. Last, FXII has been newly appreciated to be a growth factor that may influence tissue injury repair and angiogenesis. These combined studies suggest that FXII may become a pharmacologic target to reduce arterial thrombosis risk and promote cell repair after injury, without influencing hemostasis. PMID:20022081

  6. Mapping of extreme resistance to PVY (Ry (sto)) on chromosome XII using anther-culture-derived primary dihaploid potato lines.

    PubMed

    Song, Ye-Su; Hepting, Leonard; Schweizer, Günther; Hartl, Lorenz; Wenzel, Gerhard; Schwarzfischer, Andrea

    2005-09-01

    The inheritance of extreme resistance to PVY (Ry (sto)) by a single dominant locus was confirmed by obtaining a 1:1 segregation ratio in a virus inoculation test with 28 resistant (Ryry) to 29 susceptible (ryry) anther culture-derived dihaploid lines (2n=2x=24) from cv. "Assia" (2n=4x=48) having extreme resistance derived from Solanum stoloniferum in simplex constitution (Ryryryry). Twelve Ry (sto) markers selected in AFLP assays using bulked segregant analysis were applied to 106 tested potato cultivars from Germany, The Netherlands and Poland and 19 potato cultivars were identified by these markers as extremely resistant to PVY in alignment with phenotypic data. The locus for extreme resistance (Ry (sto)) to PVY was mapped on chromosome XII co-segregating with the SSR marker STM 0003. The utility of anther-culture derived dihaploid potatoes for genetic marker development was demonstrated. Marker transferability from diploids to tetraploids provides an optimistic potential for marker-assisted selection in potato breeding programs.

  7. Iridium Concentrations and Abundances of Meteoritic Ejecta from the Eltanin Impact in Sediment Cores from Polarstern Expedition ANT XII/4

    NASA Technical Reports Server (NTRS)

    Kyte, Frank T.

    2002-01-01

    The abundances of meteoritic ejecta from the Eltanin asteroid impact have been examined in several sediment cores recovered by the FS Polarstern during expedition ANT XII/4 using elemental concentrations of iridium and weights of coarse ejecta debris. Three cores with well-preserved impact deposits, PS204-1, PS2708-1, and PS2709-1, each contain Ir and ejecta fluences similar to those found in USNS Eltanin core E13-4. Small Ir anomalies and traces of ejecta were found in cores PS2706-1 and PS2710-1, but since these cores lack well-defined deposits, these are considered to be reworked and not representative of the fallout. No evidence of ejecta was found in cores PS2802-1 and PS2705-1. These results confirm earlier speculation that the Eltanin impact resulted in deposits of ejecta with up to 1 gram/sq centimeter of depris over a wide area of the ocean floor. However, there are sill large uncertainties over the actual regional or global extent of this unique sediment deposit.

  8. Factor XI deficiency enhances the pulmonary allergic response to house dust mite in mice independent of factor XII.

    PubMed

    Stroo, Ingrid; Yang, Jack; de Boer, J Daan; Roelofs, Joris J T H; van 't Veer, Cornelis; Castellino, Francis J; Zeerleder, Sacha; van der Poll, Tom

    2017-02-01

    Asthma is associated with activation of coagulation in the airways. The coagulation system can be initiated via the extrinsic tissue factor-dependent pathway or via the intrinsic pathway, in which the central player factor XI (FXI) can be either activated via active factor XII (FXIIa) or via thrombin. We aimed to determine the role of the intrinsic coagulation system and its possible route of activation in allergic lung inflammation induced by the clinically relevant human allergen house dust mite (HDM). Wild-type (WT), FXI knockout (KO), and FXII KO mice were subjected to repeated exposure to HDM via the airways, and inflammatory responses were compared. FXI KO mice showed increased influx of eosinophils into lung tissue, accompanied by elevated local levels of the main eosinophil chemoattractant eotaxin. Although gross lung pathology and airway mucus production did not differ between groups, FXI KO mice displayed an impaired endothelial/epithelial barrier function, as reflected by elevated levels of total protein and IgM in bronchoalveolar lavage fluid. FXI KO mice had a stronger systemic IgE response with an almost completely absent HDM-specific IgG1 response. The phenotype of FXII KO mice was, except for a higher HDM-specific IgG1 response, similar to that of WT mice. In conclusion, FXI attenuates part of the allergic response to repeated administration of HDM in the airways by a mechanism that is independent of activation via FXII.

  9. Quantitative analysis of substituted N,N-dimethyl-tryptamines in the presence of natural type XII alkaloids.

    PubMed

    Ivanova, Bojidarka; Spiteller, Michael

    2012-10-01

    This paper reports the qualitative and quantitative analysis (QA) of mixtures of hallucinogens, N,N-dimethyltryptamine (DMT) (1), 5-methoxy- (la) and 5-hydroxy-N,N-dimethyltryptamine (1b) in the presence of beta-carbolines (indole alkaloids of type XII) ((2), (3) and (5)}. The validated electronic absorption spectroscopic (EAs) protocol achieved a concentration limit of detection (LOD) of 7.2.10(-7) mol/L {concentration limit of quantification (LOQ) of 24.10(-7) mol/L) using bands (lambda max within 260+/-0.23-262+/-0.33 nm. Metrology, including accuracy, measurement repeatability, measurement precision, trueness of measurement, and reproducibility of the measurements are presented using N,N-dimethyltryptamine (DMA) as standard. The analytical quantities of mixtures of alkaloids 4, 6 and 7 are: lambda max 317+/-0.45, 338+/-0.69 and 430+/-0.09 for 4 (LOD, 8.6.10(-7) mol/L; LOQ, 28.66(6), mol/L), as well as 528+/-0.75 nm for 6 and 7 (LOD, 8.2.10(-7) mol/L; LOQ, 27.33(3), mol/L), respectively. The partially validated protocols by high performance liquid chromatography (HPLC), electrospray ionization (ESI), mass spectrometry (MS), both in single and tandem operation (MS/MS) mode, as well as matrix/assisted laser desorption/ionization (MALDI) MS are elaborated. The Raman spectroscopic (RS) protocol for analysis of psychoactive substances, characterized by strong fluorescence RS profile was developed, with the detection limits being discussed. The known synergistic effect leading to increase the psychoactive and hallucinogenic properties and the reported acute poisoning cases from 1-7, make the present study emergent, since as well the current lack of analytical data and the herein metrology obtained contributed to the elaboration of highly selective and precise analytical protocols, which would be of interest in the field of criminal forensic analysis.

  10. FOREWORD: The 12th International Workshop on Desorption Induced by Electronic Transitions (DIET XII) (Pine Mountain, Georgia, USA, 19-23 April 2009) The 12th International Workshop on Desorption Induced by Electronic Transitions (DIET XII) (Pine Mountain, Georgia, USA, 19-23 April 2009)

    NASA Astrophysics Data System (ADS)

    Orlando, Thomas M.; Diebold, Ulrike

    2010-03-01

    The 12th International Workshop on Desorption Induced by Electronic Transitions (DIET XII) took place from 19-23 April 2009 in Pine Mountain, Georgia, USA. This was the 12th conference in a strong and vibrant series, which dates back to the early 1980s. DIET XII continued the tradition of exceptional interdisciplinary science and focused on the study of desorption and dynamics induced by electronic excitations of surfaces and interfaces. The format involved invited lectures, contributed talks and a poster session on the most recent developments and advances in this area of surface physics. The Workshop International Steering Committee and attendees wish to dedicate DIET XII to the memory of the late Professor Theodore (Ted) Madey. Ted was one of the main pioneers of this field and was one of the primary individuals working to keep this area of science exciting and adventurous. His overall contributions to surface science were countless and his contributions to the DIET field and community were enormous. He is missed and remembered by many friends and colleagues throughout the world. The papers collected in this issue cover many of the highlights of DIET XII. Topics include ultrafast electron transfer at surfaces and interfaces, quantum and spatially resolved mapping of surface dynamics and desorption, photon-, electron- and ion-beam induced processes at complex interfaces, the role of non-thermal desorption in astrochemistry and astrophysics and laser-/ion-based methods of examining soft matter and biological media. Although the workshop attracted many scientists active in the general area of non-thermal surface processes, DIET XII also attracted many younger scientists (i.e., postdoctoral fellows, advanced graduate students, and a select number of advanced undergraduate students). This field has had an impact in a number of areas including nanoscience, device physics, astrophysics, and now biophysics. We believe that this special issue of Journal of Physics

  11. Design and synthesis of benzothiazole-6-sulfonamides acting as highly potent inhibitors of carbonic anhydrase isoforms I, II, IX and XII.

    PubMed

    Ibrahim, Diaa A; Lasheen, Deena S; Zaky, Maysoun Y; Ibrahim, Amany W; Vullo, Daniela; Ceruso, Mariangela; Supuran, Claudiu T; Abou El Ella, Dalal A

    2015-08-01

    A series of novel 2-aminobenzothiazole derivatives bearing sulfonamide at position 6 was designed, synthesized and investigated as inhibitors of four isoforms of the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1), the cytosolic CA I and II, and the tumor-associated isozymes CA IX and XII. Docking and binding energy studies were carried out to reveal details regarding the favorable interactions between the scaffolds of these new inhibitors and the active sites of the investigated CA isoforms. Most of the novel compounds were acting as highly potent inhibitors of the tumor-associated hCA IX and hCA XII with KIs in the nanomolar range. The ubiquitous and dominant rapid cytosolic isozyme hCA II was also inhibited with KIs ranging from 3.5 to 45.4 nM. The favorable interactions between some of the new compounds and the active site of different CA isoforms were delineated by using molecular docking which may be useful for designing compounds with high affinity and selectivity for some CAs with biomedical applications.

  12. The autoactivation of factor XII (Hageman factor) induced by low-Mr heparin and dextran sulphate. The effect of the Mr of the activating polyanion.

    PubMed Central

    Silverberg, M; Diehl, S V

    1987-01-01

    Human Factor XII is known to undergo autoactivation in the presence of dextran sulphate of Mr 500,000. We have now studied the dependence of this reaction on the Mr of the dextran sulphate by using fractions resolved by gel filtration. We have found that autoactivation can be induced by dextran sulphate fractions with Mr as low as 3000, and there is a marked dependence of the rate constant of autoactivation on the Mr value. Fractions with Mr below 8000 gave very low rates of autoactivation; there was a sharp increase in the rate obtained when the Mr of the dextran sulphate was greater than 10,000. Various preparations of heparin were also able to support the autoactivation of Factor XII and gave a very similar relationship between molecular size and reaction rate. The data provide support for the hypothesis that the mechanism by which the 'surface' acts in contact activation involves the presence, on the same particle, of multiple binding sites for the proteins. PMID:2449171

  13. Carbonic anhydrase inhibitors: guaiacol and catechol derivatives effectively inhibit certain human carbonic anhydrase isoenzymes (hCA I, II, IX and XII).

    PubMed

    Scozzafava, Andrea; Passaponti, Maurizio; Supuran, Claudiu T; Gülçin, İlhami

    2015-01-01

    Carbonic anhydrases (CAs) are widespread metalloenzymes in higher vertebrates including humans. A series of phenolic compounds, including guaiacol, 4-methylguaiacol, 4-propylguaiacol, eugenol, isoeugenol, vanillin, syringaldehyde, catechol, 3-methyl catechol, 4-methyl catechol and 3-methoxy catechol were investigated for their inhibition of all the catalytically active mammalian isozymes of the Zn(2+)-containing CA (EC 4.2.1.1). All the phenolic compounds effectively inhibited human carbonic anhydrase isoenzymes (hCA I, II, IX and XII), with Kis in the range of 2.20-515.98 μM. The various isozymes showed diverse inhibition profiles. Among the tested phenolic derivatives, compounds 4-methyl catechol and 3-methoxy catechol showed potent activity as inhibitors of the tumour-associated transmembrane isoforms (hCA IX and XII) in the submicromolar range, with high selectivity. The results obtained from this research may lead to the design of more effective carbonic anhydrase isoenzyme inhibitors (CAIs) based on such phenolic compound scaffolds.

  14. Long-term facial nerve function following facial reanimation after translabyrinthine vestibular schwannoma surgery: A comparison between sural grafting and VII-XII anastomosis.

    PubMed

    Wang, Zhaoyan; Zhang, Zhihua; Huang, Qi; Yang, Jun; Wu, Hao

    2013-07-01

    The aim of this study was to compare the recovery of long-term facial nerve function between patients who received sural grafts and those who underwent hypoglossal-facial anastomosis techniques following translabyrinthine vestibular schwannoma surgery. This study included 25 patients with vestibular schwannomas treated with translabyrinthine tumor removal. All patients had large tumors with a mean tumor size of 3.12 cm. Of these patients, six had progressive tumor enlargement symptoms and had been treated previously with stereotactic irradiation. Preoperatively, all patients had normal facial functions, and total tumor removal with a translabyrinthine approach was achieved in all cases. During surgery, the facial nerve was interrupted in all 25 patients. Two types of facial reanimation were performed. Sural grafts were placed in 13 patients and hypoglossal-facial (VII-XII) anastomosis was performed in the other 12. Facial nerve function and surgical outcomes were observed upon discharge, in the short term (one year following surgery), and in the long term (three years following surgery). Total facial paresis was observed in all patients upon discharge. In the sural graft group, House-Brackmann grade III facial function was achieved in four patients upon short-term evaluation and in ten upon long-term evaluation, while House-Brackmann grade IV facial function was achieved in nine patients upon short-term evaluation and three in the long term. In the VII-XII anastomosis group, House-Brackmann grade III facial function was achieved in two patients in the short term and eight in the long term, and House-Brackmann grade IV facial function was achieved in ten patients in the short term and four in the long term. There was a statistically significant difference in the facial recovery results between the short- and long-term follow-up periods. The sural graft group exhibited a marked improvement in results compared with the VII-XII anastomosis group, but no statistically

  15. XII Recontres De Blois

    NASA Technical Reports Server (NTRS)

    Kaluzienski, Louis (Technical Monitor); Forman, William

    2004-01-01

    In the initial awarding of the grant, we had difficulty phasing our proposed support of graduate students, postdoctoral fellows and young US scientists with the meeting schedule and the grant cycle. Initially, the grant arrived too late to support the meeting. The following year, a combination of the renewal process and the meeting announcement prevented us from announcing the support opportunity sufficiently in advance to allow us to make awards and provide support. As described in the initial proposal, the Moriond and Blois meetings are a unique opportunity for younger researchers to make oral presentations of their work at an international venue. As noted above, the phasing of meetings combined with the difficulty of arranging foreign travel for scientists at other institutions precluded the possibility of supporting the proposed meetings and providing young US scientists and post-doctoral fellows support to attend these meetings.

  16. Factor XII assay

    MedlinePlus

    ... D, Neff AT. Rare coagulation factor deficiencies. In: Hoffman R, Benz EJ Jr, Silberstein LE, Heslop HE, ... Laboratory evaluation of hemostatic and thrombotic disorders. In: Hoffman R, Benz EJ Jr, Silberstein LE, Heslop HE, ...

  17. Collagen type XII and versican are present in the early stages of cartilage tissue formation by both redifferentating passaged and primary chondrocytes.

    PubMed

    Taylor, Drew W; Ahmed, Nazish; Parreno, Justin; Lunstrum, Gregory P; Gross, Allan E; Diamandis, Eleftherios P; Kandel, Rita A

    2015-02-01

    Current approaches to cartilage tissue engineering require a large number of chondrocytes. Although chondrocyte numbers can be expanded in monolayer culture, the cells dedifferentiate and unless they can be redifferentiated are not optimal to use for cartilage repair. We took advantage of the differential effect of culture conditions on the ability of passaged and primary chondrocytes to form cartilage tissue to dissect out the extracellular matrix (ECM) molecules produced and accumulated in the early stages of passaged cell cartilage tissue formation as we hypothesized that passaged bovine cells that form cartilage accumulate a pericellular matrix that differs from cells that do not form cartilage. Twice passaged bovine chondrocytes (P2) (cartilage forming), or as a control primary chondrocytes (P0) (which do not generate cartilage), were cultured on three-dimensional membrane inserts in serum-free media. P2 redifferentiation was occurring during the first 8 days as indicated by increased expression of the chondrogenic genes Sox9, collagen type II, aggrecan, and COMP, suggesting that this is an appropriate time period to examine the ECM. Mass spectrometry showed that the P2 secretome (molecules released into the media) at 1 week had higher levels of collagen types I, III, and XII, and versican while type II collagen and COMP were found at higher levels in the P0 secretome. There was increased collagen synthesis and retention by P2 cells compared to P0 cells as early as 3 days of culture. Confocal microscopy showed that types XII, III, and II collagen, aggrecan, versican, and decorin were present in the ECM of P2 cells. In contrast, collagen types I, II, and III, aggrecan, and decorin were present in the ECM of P0 cells. As primary chondrocytes grown in serum-containing media, a condition that allows for the generation of cartilage tissue in vitro, also accumulate versican and collagen XII, this study suggests that these molecules may be necessary to provide a

  18. CT-clinical approach to patients with symptoms related to the V, VII, IX-XII cranial nerves and cervical sympathetics

    SciTech Connect

    Kalovidouris, A.; Mancuso, A.A.; Dillon, W.

    1984-06-01

    Forty-three patients who had signs and symptoms possibly related to the extracranial course of cranial nerves V, VII, IX, X-XII, and the cervical sympathetics were examined prospectively using high resolution CT to obtain images of thin sections during rapid drip infusion of contrast material. Anatomic areas in the scan protocols included the posterior fossa, cavernous and paranasal sinuses, skull base, temporal bone, nasopharynx, parotid gland, tongue base, and neck. Nine of the 23 patients with possible fifth nerve deficits had extracranial structural lesions that explained the symptoms; none of these nine, however, had typical trigeminal neuralgia. Of eight patients with peripheral seventh nerve abnormalities, two had positive findings on scans. Of five patients presenting with referred ear pain, three had carcinoma of the upper aerodigestive tract. The authors' experience suggests that patients at high risk for structural lesions responsible for cranial nerve deficits can be selected by clinical criteria. Protocols for each clinical setting are presented.

  19. A Keck/DEIMOS spectroscopic survey of the faint M31 satellites AndIX, AndXI, AndXII and AndXIII†

    NASA Astrophysics Data System (ADS)

    Collins, M. L. M.; Chapman, S. C.; Irwin, M. J.; Martin, N. F.; Ibata, R. A.; Zucker, D. B.; Blain, A.; Ferguson, A. M. N.; Lewis, G. F.; McConnachie, A. W.; Peñarrubia, J.

    2010-10-01

    We present the first spectroscopic analysis of the faint M31 satellite galaxies, AndXI and AndXIII, as well as a re-analysis of existing spectroscopic data for two further faint companions, AndIX (correcting for an error in earlier geometric modelling that caused a misclassification of member stars in previous work) and AndXII. By combining data obtained using the Deep Imaging Multi-Object Spectrograph (DEIMOS) mounted on the Keck II telescope with deep photometry from the Suprime-Cam instrument on Subaru, we have identified the most probable members for each of the satellites based on their radial velocities (precise to several down to i ~ 22), distance from the centre of the dwarf spheroidal galaxies (dSphs) and their photometric [Fe/H]. Using both the photometric and spectroscopic data, we have also calculated global properties for the dwarfs, such as systemic velocities, metallicities and half-light radii. We find each dwarf to be very metal poor ([Fe/H] ~ -2 both photometrically and spectroscopically, from their stacked spectrum), and as such, they continue to follow the luminosity-metallicity relationship established with brighter dwarfs. We are unable to resolve dispersion for AndXI due to small sample size and low signal-to-noise ratio, but we set a 1σ upper limit of σv < 4.5kms-1. For AndIX, AndXII and AndXIII we resolve velocity dispersions of σv = 4.5+3.6-3.4, 2.6+5.1-2.6 and 9.7+8.9-4.5kms-1, though we note that the dispersion for AndXIII is based on just three stars. We derive masses within the half-light radii for these galaxies of 6.2+5.3-5.1 × 106, 2.4+6.5-2.4 × 106 and 1.1+1.4-0.7 × 107Msolar, respectively. We discuss each satellite in the context of the Mateo relations for dSphs, and in reference to the universal halo profiles established for Milky Way dwarfs. Both AndIX and AndXII fall below the universal halo profiles of Walker et al., indicating that they are less massive than would be expected for objects of their half-light radius. When

  20. A probable case of gigantism/acromegaly in skeletal remains from the Jewish necropolis of "Ronda Sur" (Lucena, Córdoba, Spain; VIII-XII centuries CE).

    PubMed

    Viciano, Joan; De Luca, Stefano; López-Lázaro, Sandra; Botella, Daniel; Diéguez-Ramírez, Juan Pablo

    2015-01-01

    Pituitary gigantism is a rare endocrine disorder caused by hypersecretion of growth hormone during growing period. Individuals with this disorder have an enormous growth in height and associated degenerative changes. The continued hypersecretion of growth hormone during adulthood leads to acromegaly, a condition related to the disproportionate bone growth of the skull, hands and feet. The skeletal remains studied belong to a young adult male from the Jewish necropolis of "Ronda Sur" in Lucena (Córdoba, Spain, VIII-XII centuries CE). The individual shows a very large and thick neurocranium, pronounced supraorbital ridges, an extremely prominent occipital protuberance, and an extremely large and massive mandible. Additional pathologies include enlargement of the vertebral bodies with degenerative changes, thickened ribs, and a slight increased length of the diaphysis with an increased cortical bone thickness of lower limbs. Comparative metric analysis of the mandible with other individuals from the same population and a contemporary Mediterranean population shows a trend toward acromegalic morphology. This case is an important contribution in paleopathological literature because it is a rare condition that has not been widely documented in ancient skeletal remains.

  1. Preliminary report on AED deployment on the entire Air France commercial fleet: a joint venture with Paris XII University Training Programme.

    PubMed

    Bertrand, C; Rodriguez Redington, P; Lecarpentier, E; Bellaiche, G; Michel, D; Teiger, E; Morris, W; Le Bourgeois, J P; Barthout, M

    2004-11-01

    The positive effect of early defibrillation on survival from cardiac arrest has been demonstrated. We describe the use of AEDs over 1 year following the training of flight attendants. Air France and the University of Paris XII together designed a 1 year training programme for 14000 flight attendants. The university emergency departments (SAMU) provided 250 instructors. AEDs training and certification was conducted for crew members between November 2001 and November 2002. By January 2003, all aircraft were fully equipped with AEDs. All cases of cardiac arrest that occurred during the study were reviewed comprehensively. Comments from the crew were collected. Twelve cardiac arrests were reported between November 2002 and November 2003 out of 4194 cases of emergency care delivered to passengers. Shock treatment was advised initially in 5/12 cases. The survival rate after in-flight cardiac arrest was 3/12. The survival rate at discharge from hospital following in flight shock was 2/5. No complications arose from the use of AEDs. Training by professionals gave the flight attendants confidence and allowed for the survival of two young passengers. Our study highlights the ability of flight attendants to give better onboard care for the future. The next step is to consolidate the network between in-flight care and the medical dispatch centre in Paris.

  2. Water balance and flow rate discharge on a receiving water body: Application to the B-XII Irrigation District in Spain

    NASA Astrophysics Data System (ADS)

    Moyano, Maria C.; Tornos, Lucia; Juana, Luis

    2015-08-01

    The quantification of the main water balance components becomes necessary to diminish the pollutants load from drainage, and its harmful effect on the environment, aggravated within a context of increasing water scarcity. As a first approach to the hydrological study of the 15,000 ha B-XII Irrigation District in Spain, a conceptual lumped model entitled WATEN has been developed, aiming to calculate the monthly flow rate discharge to the Guadalquivir River over the period 2002-2012. The model requires as inputs, irrigation, precipitation and potential crop evapotranspiration. Main model parameters are the total and readily available moisture in the soil, the effective rainfall and the irrigation efficiency. Energy consumption for drainage discharge was used for calibration. Both classical optimization and a robust approach based on Monte Carlo were performed. In order to diminish computational requirements, Monte Carlo was not haphazardly applied, but conducted on a similar manner to genetic algorithms, entitled Parameters Estimation on Driven Trials (PEDT). The model attained an average Nash-Sutcliffe coefficient e2 ≅ 0.90 between observed and estimated drainage discharge. It was detected a significant crop evapotranspiration reduction compared to potential values. The volume of water discharged to the river might be sufficient for leaching irrigation water salts.

  3. Los Alamos National Laboratory.

    ERIC Educational Resources Information Center

    Hammel, Edward F., Jr.

    1982-01-01

    Current and post World War II scientific research at the Los Alamos National Laboratory (New Mexico) is discussed. The operation of the laboratory, the Los Alamos consultant program, and continuation education, and continuing education activities at the laboratory are also discussed. (JN)

  4. The GAPS Programme with HARPS-N at TNG. XII. Characterization of the planetary system around HD 108874

    NASA Astrophysics Data System (ADS)

    Benatti, S.; Desidera, S.; Damasso, M.; Malavolta, L.; Lanza, A. F.; Biazzo, K.; Bonomo, A. S.; Claudi, R. U.; Marzari, F.; Poretti, E.; Gratton, R.; Micela, G.; Pagano, I.; Piotto, G.; Sozzetti, A.; Boccato, C.; Cosentino, R.; Covino, E.; Maggio, A.; Molinari, E.; Smareglia, R.; Affer, L.; Andreuzzi, G.; Bignamini, A.; Borsa, F.; di Fabrizio, L.; Esposito, M.; Martinez Fiorenzano, A.; Messina, S.; Giacobbe, P.; Harutyunyan, A.; Knapic, C.; Maldonado, J.; Masiero, S.; Nascimbeni, V.; Pedani, M.; Rainer, M.; Scandariato, G.; Silvotti, R.

    2017-03-01

    In order to understand the observed physical and orbital diversity of extrasolar planetary systems, a full investigation of these objects and of their host stars is necessary. Within this field, one of the main purposes of the GAPS observing project with HARPS-N at TNG is to provide a more detailed characterization of already known systems. In this framework we monitored the star, hosting two giant planets, HD 108874, with HARPS-N for three years in order to refine the orbits, to improve the dynamical study and to search for additional low-mass planets in close orbits. We subtracted the radial velocity (RV) signal due to the known outer planets, finding a clear modulation of 40.2 d period. We analysed the correlation between RV residuals and the activity indicators and modelled the magnetic activity with a dedicated code. Our analysis suggests that the 40.2 d periodicity is a signature of the rotation period of the star. A refined orbital solution is provided, revealing that the system is close to a mean motion resonance of about 9:2, in a stable configuration over 1 Gyr. Stable orbits for low-mass planets are limited to regions very close to the star or far from it. Our data exclude super-Earths with Msini ≳ 5M⊕ within 0.4 AU and objects with Msini ≳ 2M⊕ with orbital periods of a few days. Finally we put constraints on the habitable zone of the system, assuming the presence of an exomoon orbiting the inner giant planet. Based on observations made with the Italian Telescopio Nazionale Galileo (TNG) operated on the island of La Palma by the Fundación Galileo Galilei of the INAF at the Spanish Observatorio del Roque de los Muchachos of the IAC in the frame of the programme Global Architecture of Planetary Systems (GAPS).Table A.1 is also available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/599/A90

  5. New Identifications of Fe IX, Fe X, Fe XI, Fe XII, and Fe XIII Lines in the Spectrum of Procyon Observed with the Chandra X-Ray Observatory

    NASA Astrophysics Data System (ADS)

    Beiersdorfer, P.; Lepson, J. K.; Desai, P.; Díaz, F.; Ishikawa, Y.

    2014-02-01

    We have analyzed 280 ks of co-added observations performed with Chandra's Low Energy Transmission Grating Spectrometer using theoretical spectra of Fe VIII through Fe XVII. The model spectral data were produced by combining collisional excitation data generated with the Flexible Atomic Code and transition energies generated with a relativistic code based on the multi-reference Møller-Plesset perturbation theory. The spectroscopic accuracy of the theoretical Fe IX wavelengths was ascertained in a comparison with existing laboratory measurements. We find several new Fe IX lines in the 100-140 Å region and confirm two previous identifications. We also have identified a new line from Fe X near 111 Å several weak features near 102 Å may also be ascribed to Fe X. A line near 100.5 Å is identified as originating from Fe XI; a neighboring feature near 101 Å may also be from Fe XI. A cluster of three weak lines between 117 and 118 Å may be ascribed to Fe XII. Two lines near 104 and 106 Å, respectively, have been assigned to Fe XIII. In addition, we confirmed the presence of two out of four Fe VIII lines that were thought to exist in the spectrum. These two lines are located near 131 Å. The Fe IX emission is weakly sensitive to the assumed electron density, while the Fe XIII is strongly dependent on density. We find that a density between 109 and 1010 cm-3 provides the best fit to the Procyon spectrum. We note that several of the new identifications have come at the expense of prior assignments to magnesium or calcium lines, removing evidence for the presence of these elements in this spectral region. No evidence for Fe XVIII, Fe XIX, or Fe XX was found.

  6. Hereditary angioedema with normal C1 inhibitor and factor XII mutation: a series of 57 patients from the French National Center of Reference for Angioedema.

    PubMed

    Deroux, A; Boccon-Gibod, I; Fain, O; Pralong, P; Ollivier, Y; Pagnier, A; Djenouhat, K; Du-Thanh, A; Gompel, A; Faisant, C; Launay, D; Bouillet, L

    2016-09-01

    Hereditary angioedema (HAE) is a rare disease associated with either a quantitative or qualitative deficiency in C1-inhibitor (C1-INH) or normal C1-INH. HAE with normal C1-INH is associated in 20% of cases with mutations in the gene for factor XII (FXII) or FXII-HAE. A recent review described 41 families, including 14 German and 15 Spanish families. We have constructed a register of French patients and their characteristics. A national survey was launched through the French National Center of Reference for Angioedema (CREAK) to study the clinical, biological and therapeutic characteristics of patients with HAE linked to a mutation of FXII gene. Fifty-seven patients were identified from 24 different families. In most cases they were young women (mean age at diagnosis: 31 years, mean age at first symptom: 21 years, female/male ratio: 76%). Twenty-one per cent of the patients experienced angioedema attacks only during pregnancy or when on oestrogen contraception. Sixty-three per cent had attacks at all times, but they were more severe during these same periods. Male carriers of the mutation were more frequently asymptomatic than females (P = 0·003). C1-INH concentrate and icatibant were both effective for treating attacks. The prophylactic use of tranexamic acid led to a 64% decrease in the number of attacks. This is one of the largest series reported of HAE patients with FXII mutation. The therapeutic management appeared to be identical to that of HAE with C1-INH deficiency.

  7. Interactions outside the proteinase-binding loop contribute significantly to the inhibition of activated coagulation factor XII by its canonical inhibitor from corn.

    PubMed

    Korneeva, Vera A; Trubetskov, Mikhail M; Korshunova, Alena V; Lushchekina, Sofya V; Kolyadko, Vladimir N; Sergienko, Olga V; Lunin, Vladimir G; Panteleev, Mikhail A; Ataullakhanov, Fazoil I

    2014-05-16

    Activated factor XII (FXIIa) is selectively inhibited by corn Hageman factor inhibitor (CHFI) among other plasma proteases. CHFI is considered a canonical serine protease inhibitor that interacts with FXIIa through its protease-binding loop. Here we examined whether the protease-binding loop alone is sufficient for the selective inhibition of serine proteases or whether other regions of a canonical inhibitor are involved. Six CHFI mutants lacking different N- and C-terminal portions were generated. CHFI-234, which lacks the first and fifth disulfide bonds and 11 and 19 amino acid residues at the N and C termini, respectively, exhibited no significant changes in FXIIa inhibition (Ki = 3.2 ± 0.4 nm). CHFI-123, which lacks 34 amino acid residues at the C terminus and the fourth and fifth disulfide bridges, inhibited FXIIa with a Ki of 116 ± 16 nm. To exclude interactions outside the FXIIa active site, a synthetic cyclic peptide was tested. The peptide contained residues 20-45 (Protein Data Bank code 1BEA), and a C29D substitution was included to avoid unwanted disulfide bond formation between unpaired cysteines. Surprisingly, the isolated protease-binding loop failed to inhibit FXIIa but retained partial inhibition of trypsin (Ki = 11.7 ± 1.2 μm) and activated factor XI (Ki = 94 ± 11 μm). Full-length CHFI inhibited trypsin with a Ki of 1.3 ± 0.2 nm and activated factor XI with a Ki of 5.4 ± 0.2 μm. Our results suggest that the protease-binding loop is not sufficient for the interaction between FXIIa and CHFI; other regions of the inhibitor also contribute to specific inhibition.

  8. SOPHIE velocimetry of Kepler transit candidates. XII. KOI-1257 b: a highly eccentric three-month period transiting exoplanet

    NASA Astrophysics Data System (ADS)

    Santerne, A.; Hébrard, G.; Deleuil, M.; Havel, M.; Correia, A. C. M.; Almenara, J.-M.; Alonso, R.; Arnold, L.; Barros, S. C. C.; Behrend, R.; Bernasconi, L.; Boisse, I.; Bonomo, A. S.; Bouchy, F.; Bruno, G.; Damiani, C.; Díaz, R. F.; Gravallon, D.; Guillot, T.; Labrevoir, O.; Montagnier, G.; Moutou, C.; Rinner, C.; Santos, N. C.; Abe, L.; Audejean, M.; Bendjoya, P.; Gillier, C.; Gregorio, J.; Martinez, P.; Michelet, J.; Montaigut, R.; Poncy, R.; Rivet, J.-P.; Rousseau, G.; Roy, R.; Suarez, O.; Vanhuysse, M.; Verilhac, D.

    2014-11-01

    Observatorio del Roque de los Muchachos of the Instituto de Astrofisica de Canarias. Part of the observations were made with the IAC80 operated on the Spanish Observatorio del Teide of the Instituto de Astrofísica de Canarias.Appendices are available in electronic form at http://www.aanda.orgFull Tables C.5-C.7 are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/571/A37

  9. Stockpile Stewardship: Los Alamos

    ScienceCinema

    McMillan, Charlie; Morgan, Nathanial; Goorley, Tom; Merrill, Frank; Funk, Dave; Korzekwa, Deniece; Laintz, Ken

    2016-07-12

    "Heritage of Science" is a short video that highlights the Stockpile Stewardship program at Los Alamos National Laboratory. Stockpile Stewardship was conceived in the early 1990s as a national science-based program that could assure the safety, security, and effectiveness of the U.S. nuclear deterrent without the need for full-scale underground nuclear testing. This video was produced by Los Alamos National Laboratory for screening at the Lab's Bradbury Science Museum in Los Alamos, NM and is narrated by science correspondent Miles O'Brien.

  10. Coagulation factor XII genetic variation, ex vivo thrombin generation, and stroke risk in the elderly: results from the Cardiovascular Health Study

    PubMed Central

    Olson, N. C.; Butenas, S.; Lange, L. A.; Lange, E. M.; Cushman, M.; Jenny, N. S.; Walston, J.; Souto, J. C.; Soria, J. M.; Chauhan, G.; Debette, S.; Longstreth, W.T.; Seshadri, S.; Reiner, A.P.; Tracy, R. P.

    2016-01-01

    Background Relationships of thrombin generation (TG) with cardiovascular disease risk are under-evaluated in population-based cohorts. Objectives Evaluate the relationships of TG influenced by the contact and tissue factor coagulation pathways ex vivo with common SNPs and incident cardiovascular disease and stroke. Patients/Methods We measured peak TG (pTG) in baseline plasma samples of Cardiovascular Health Study participants (n=5,411), both with and without inhibitory anti-FXIa antibody (pTG/FXIa−). We evaluated their associations with ~50K SNPs using the IBCv2 genotyping array, and with incident cardiovascular disease and stroke events over a median follow-up of 13.2-years. Results The minor allele for a SNP in the coagulation factor XII gene (F12), rs1801020, was associated with lower pTG in European-Americans (β=−34.2 nM ± 3.5 nM; p=3.3×10−22; minor allele frequency (MAF) =0.23) and African-Americans (β=−31.1 nM ± 7.9 nM; p=9.0×10−5; MAF=0.42). Lower FXIa-independent pTG (pTG/FXIa−) was associated with the F12 rs1801020 minor allele, and higher pTG/FXIa− was associated with the ABO SNP rs657152 minor allele (β=16.3 nM; p=4.3×10−9; MAF=0.37). The risk factor-adjusted ischemic stroke hazard ratio (95% confidence interval) was 1.09 (1.01, 1.17; p=0.03) for pTG, 1.06 (0.98, 1.15; p=0.17) for pTG/FXIa−, and 1.11 (1.02, 1.21; p=0.02) for FXIa-dependent pTG (pTG/FXIa+), per 1-SD increment (n=834 ischemic strokes). In a multi-cohort candidate gene analysis, rs1801020 was not associated with incident ischemic stroke (β= −0.02; (SE=0.08); p=0.81). Conclusions These results support the importance of contact activation pathway-dependent TG as a risk factor for ischemic stroke and indicate the importance of F12 SNPs on TG ex vivo and in vivo. PMID:26286125

  11. Los Alamos offers Fellowships

    NASA Astrophysics Data System (ADS)

    Los Alamos National Laboratory in New Mexico is calling for applications for postdoctoral appointments and research fellowships. The positions are available in geoscience as well as other scientific disciplines.The laboratory, which is operated by the University of California for the Department of Energy, awards J. Robert Oppenheimer Research Fellowships to scientists that either have or will soon complete doctoral degrees. The appointments are for two years, are renewable for a third year, and carry a stipend of $51,865 per year. Potential applicants should send a resume or employment application and a statement of research goals to Carol M. Rich, Div. 89, Human Resources Development Division, MS P290, Los Alamos National Laboratory, Los Alamos, New Mexico 87545 by mid-November.

  12. Taxquake in Los Angeles

    ERIC Educational Resources Information Center

    Koltai, Leslie

    1978-01-01

    Outlines educational, personnel, legal, and political considerations facing the Los Angeles Community College District contingency planning committee in their efforts to develop plans to meet budgetary limitations foreseen in the passage of the Jarvis-Gann property tax limitation initiative. (TP)

  13. The Los Alamos primer

    SciTech Connect

    Serber, R.

    1992-01-01

    This book contains the 1943 lecture notes of Robert Serber. Serber was a protege of J. Robert Oppenheimer and member of the team that built the first atomic bomb - reveal what the Los Alamos scientists knew, and did not know, about the terrifying weapon they were building.

  14. Factor XII (Hageman factor) deficiency

    MedlinePlus

    ... Review Date 1/22/2015 Updated by: Rita Nanda, MD, assistant professor of medicine, section of hematology/ ... constitute endorsements of those other sites. Copyright 1997-2017, A.D.A.M., Inc. Duplication for commercial ...

  15. International Congress on Glass XII

    SciTech Connect

    Doremus, R H; LaCourse, W C; Mackenzie, J D; Varner, J R; Wolf, W W

    1980-01-01

    A total of 158 papers are included under nine headings: structure and glass formation; optical properties; electrical and magnetic properties; mechanical properties and relaxation; mass transport; chemical durability and surfaces; nucleation; crystallization; and glass ceramics; processing; and automatic controls. Separate abstracts were prepared for eight papers; four of the remaining papers had been processed previously for the data base. (DLC)

  16. Identification of the zinc-dependent endothelial cell binding protein for high molecular weight kininogen and factor XII: identity with the receptor that binds to the globular "heads" of C1q (gC1q-R).

    PubMed Central

    Joseph, K; Ghebrehiwet, B; Peerschke, E I; Reid, K B; Kaplan, A P

    1996-01-01

    High molecular weight kininogen (HK) and factor XII are known to bind to human umbilical vein endothelial cells (HUVEC) in a zinc-dependent and saturable manner indicating that HUVEC express specific binding site(s) for those proteins. However, identification and immunochemical characterization of the putative receptor site(s) has not been previously accomplished. In this report, we have identified a cell surface glycoprotein that is a likely candidate for the HK binding site on HUVECs. When solubilized HUVEC membranes were subjected to an HK-affinity column in the presence or absence of 50 microM ZnCl2 and the bound membrane proteins eluted, a single major protein peak was obtained only in the presence of zinc. SDS/PAGE analysis and silver staining of the protein peak revealed this protein to be 33 kDa and partial sequence analysis matched the NH2 terminus of gC1q-R, a membrane glycoprotein that binds to the globular "heads" of C1q. Two other minor proteins of approximately 70 kDa and 45 kDa were also obtained. Upon analysis by Western blotting, the 33-kDa band was found to react with several monoclonal antibodies (mAbs) recognizing different epitopes on gC1q-R. Ligand and dot blot analyses revealed zinc-dependent binding of biotinylated HK as well as biotinylated factor XII to the isolated 33-kDa HUVEC molecule as well as recombinant gC1q-R. In addition, binding of 125I-HK to HUVEC cells was inhibited by selected monoclonal anti-gC1q-R antibodies. C1q, however, did not inhibit 125I-HK binding to HUVEC nor did those monoclonals known to inhibit C1q binding to gC1q-R. Taken together, the data suggest that HK (and factor XII) bind to HUVECs via a 33-kDa cell surface glycoprotein that appears to be identical to gC1q-R but interact with a site on gC1q-R distinct from that which binds C1q. Images Fig. 1 Fig. 3 Fig. 4 Fig. 5 PMID:8710908

  17. Los Alamos Programming Models

    SciTech Connect

    Bergen, Benjamin Karl

    2016-07-07

    This is the PDF of a powerpoint presentation from a teleconference on Los Alamos programming models. It starts by listing their assumptions for the programming models and then details a hierarchical programming model at the System Level and Node Level. Then it details how to map this to their internal nomenclature. Finally, a list is given of what they are currently doing in this regard.

  18. Los Alamos National Laboratory

    SciTech Connect

    Dogliani, Harold O

    2011-01-19

    The purpose of the briefing is to describe general laboratory technical capabilities to be used for various groups such as military cadets or university faculty/students and post docs to recruit into a variety of Los Alamos programs. Discussed are: (1) development and application of high leverage science to enable effeictive, predictable and reliability outcomes; (2) deter, detect, characterize, reverse and prevent the proliferation of weapons of mass destruction and their use by adversaries and terrorists; (3) modeling and simulation to define complex processes, predict outcomes, and develop effective prevention, response, and remediation strategies; (4) energetic materials and hydrodynamic testing to develop materials for precise delivery of focused energy; (5) materials cience focused on fundamental understanding of materials behaviors, their quantum-molecular properties, and their dynamic responses, and (6) bio-science to rapidly detect and characterize pathogens, to develop vaccines and prophylactic remedies, and to develop attribution forensics.

  19. EFFECT OF LASER LIGHT ON MATTER. LASER PLASMAS: Use of a laser plasma in determination of a resonance defect of the Lyα1,2 lines of Mg XII and the 2s—3p lines of Ge XXIII

    NASA Astrophysics Data System (ADS)

    Bryunetkin, B. A.; Dyakin, V. M.; Nilsen, J.; Skobelev, I. Yu; Pikuz, S. A.; Faenov, A. Ya; Khakhalin, S. Ya

    1994-02-01

    Precision measurements were made of the wavelengths of the satellites of the resonance line of the H-like Mg XII ion as well as of a number of transitions in the Ne-like Ge XXIII ion and their satellites in a plasma created by radiation generated in an Nd-glass laser. The measurements were carried out with a high-resolution, high-luminosity spectrograph containing a mica crystal bent to a spherical surface with a radius R = 100 mm. The absolute wavelength obtained for the 2s22p6 1So—2s2p63p 3P1 transition in Ge XXIII was λ = 842.08 ± 0.09 pm. The results demonstrated that the short-wavelength component of the Lyman doublet of Mg XII (λ = 841.92 pm) could be used to pump optically a short-wavelength laser by transitions in the Ge XXIII ion.

  20. [Nutrition and child development I; nutritional status of school children in a peripheral district of Madrid (Rev Clin Esp 1944; XII:87-94)].

    PubMed

    Grande Covián, F; Rof Carballo, J; Jiménez García, F; Morata Cernuda, A

    2014-09-01

    El estudio clínico del estado nutritivo de un grupo de niños en edad escolar, habitantes de un suburbio madrileño revela la existencia, relativamente rara, de signos carenciales específicos, que contrasta vivamente con el considerable retraso que se observa en su desarrollo somático. Los hechos parecen demostrar que el problema nutritivo de estos niños es sobre todo un problema cuantitativo. El retraso de la evolución está en relación con la insuficiencia global de la dieta y con el déficit de calcio que es probablemente el elemento individual con mayor grado de carencia en las dietas. La anemia que presenta el 98% de los niños no parece deberse únicamente a una deficiencia de hierro porque la dieta parece tener una cantidad adecuada; probablemente esté más en relación con el exiguo contenido de proteínas animales de la ración.

  1. La Educacion de los Jesuitas en Cuba durante el Siglo XVI (1566-1574) (Jesuit Education in Cuba during the 16th Century (1566-1574).

    ERIC Educational Resources Information Center

    Puentes, Roberto Valdes

    2000-01-01

    Explains the relationship between Spanish colonialism in Cuba, evangelization of the Indians, and the origins of Cuban culture, as well as the role the Jesuits played in this process of transculturation. Analyzes the first phase in the history of the educational work of the Jesuits in Cuba (1566-1574). (BT)

  2. Los biocombustibles y el futuro

    NASA Video Gallery

    ¿Cómo podremos utilizar los biocombustibles en el futuro? La ingeniera aeroespacial de la NASA, Diana Centeno Gómez nos explica el futuro de los biocombustibles y cómo un día podrías trabajar con d...

  3. [Four stages in the history of the Centro Médico Nacional Siglo XXI of the IMSS].

    PubMed

    Fajardo-Ortiz, Guillermo

    2015-01-01

    This document presents four stages in the history of the Centro Médico Nacional Siglo XXI (Centro Médico Nacional XXI Century) of the Instituto Mexicano del Seguro Social. The first stage started at the end of the third decade of the twentieth century and ended in 1961, it corresponded to the conception, planning and construction of what was to be the Centro Médico del Distrito Federal (Centro Médico of the Distrito Federal) belonging to the Secretaría de Salubridad y Asistencia (Ministry of Health and Assistance). The second stage began when the Center was acquired by the Institute, then was known like Centro Médico Nacional (Centro Médico Nacional ), being put into full operation in 1963, more than twenty-two years later, in 1985, an earthquake virtually ended it, immediately began its reconstruction, finishing the second stage. In 1989 began the third stage, different and new buildings complemented or replaced the structures damaged or destroyed by the earthquake which formed the now Centro Médico Nacional Siglo XXI (Centro Médico Nacional XXI Century). In 2004 the fourth stage opened when the four hospitals of the Center were categorized like Unidades Médicas de Alta Especialidad (High Specialized Medical Units).

  4. Mineralogy and technology of bricks used for the construction of the XII century ducal castle on the island of Ostrów Tumski, Wrocław (SW Poland)

    NASA Astrophysics Data System (ADS)

    Bartz, W.; Chorowska, M.

    2016-12-01

    The historic bricks from the ducal castle on Ostrów Tumski (Wrocław), one of the first brickwork structures in the Lower Silesia, which dates back to the XII and XIII century, were studied and characterised by a combination of classical petrographic studies (polarising microscopy), scanning microscopy, thermal analysis and X-ray diffraction. The combined results of these methods suggest that the firing temperature ranges from 950°C, through the most common temperatures of 850-900°C, to the infrequent temperatures below 750°C. Most of the bricks were fired under oxidising conditions, occasionally over a sequence of oxidising and reducing steps, resulting in a sandwich structure. The results indicate, that low-calcareous raw materials were used, presumably Miocene-Pliocene `flamy clays', exploited a few kilometres away from the castle and tempered with locally obtained sand from the Odra river. Only small differences have been recognized in: 1) clay to aplastic material ratio, 2) amount of accessory minerals, 3) grain-size distribution of aplastic materials, but no significant changes in the brick technology were observed. The observed variability corresponds well to the different constructing phases, identified previously on the basis of archaeological work. Thus, our work proves that a detailed mineralogical and petrological study may help to identify different construction phases in historic monuments.

  5. Los Angeles Beach Harbors, Los Angeles County, California.

    DTIC Science & Technology

    1974-10-01

    Outdoor Recreation, USDI, Agricultural Research Service, USDA Pacific Southwest Regional Office Soil Conservation Service, USDA Geological Survey, USDI...of channels through a coastal salt marsh (once the estuary of the Los Angeles River ), filling of adjacent marshland areas, and both dredging and...the harbor area comes from: (a) the Los Angeles River , which drains an 832-square-mile basin, and (b) Dominguez Channel, an 8.5-mile-long structure

  6. COSMOGRAIL: the COSmological MOnitoring of GRAvItational Lenses. XII. Time delays of the doubly lensed quasars SDSS J1206+4332 and HS 2209+1914

    NASA Astrophysics Data System (ADS)

    Eulaers, E.; Tewes, M.; Magain, P.; Courbin, F.; Asfandiyarov, I.; Ehgamberdiev, Sh.; Rathna Kumar, S.; Stalin, C. S.; Prabhu, T. P.; Meylan, G.; Van Winckel, H.

    2013-05-01

    Aims: Within the framework of the COSMOGRAIL collaboration we present 7- and 8.5-year-long light curves and time-delay estimates for two gravitationally lensed quasars: SDSS J1206+4332 and HS 2209+1914. Methods: We monitored these doubly lensed quasars in the R-band using four telescopes: the Mercator, Maidanak, Himalayan Chandra, and Euler telescopes, together spanning a period of 7 to 8.5 observing seasons from mid-2004 to mid-2011. The photometry of the quasar images was obtained through simultaneous deconvolution of these data. The time delays were determined from these resulting light curves using four very different techniques: a dispersion method, a spline fit, a regression difference technique, and a numerical model fit. This minimizes the bias that might be introduced by the use of a single method. Results: The time delay for SDSS J1206+4332 is ΔtAB = 111.3 ± 3 days with A leading B, confirming a previously published result within the error bars. For HS 2209+1914 we present a new time delay of ΔtBA = 20.0 ± 5 days with B leading A. Conclusions: The combination of data from up to four telescopes have led to well-sampled and nearly 9-season-long light curves, which were necessary to obtain these results, especially for the compact doubly lensed quasar HS 2209+1914. Based on observations made with the 1.2-m Swiss Euler telescope (La Silla, Chile), the 1.5-m AZT-22 telescope (Maidanak Observatory, Uzbekistan), the 2.0-m HCT telescope (Hanle, India), and the 1.2-m Mercator Telescope. Mercator is operated on the island of La Palma by the Flemish Community, at the Spanish Observatorio del Roque de los Muchachos of the Instituto de Astrofísica de Canarias.Numerical values of light curves are only available at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/553/A121 and at http://www.cosmograil.org

  7. Interactions among Hageman factor (HG, Factor XII), plasma thromboplastin antecedent (PTA, Factor XI), plasma prekallikrein (PK, Fletcher factor) and high molecular weight kininogen (HMW-K, Fitzgerald factor) in blood coagulation.

    PubMed

    Saito, H; Ratnoff, O D

    1979-01-01

    Studies of plasmas from individuals with Hageman trait (factor XII deficiency), plasma thromboplastin antecedent (PTA, factor XI) deficiency, Fletcher trait (plasma prekallikrein deficiency) and Fitzgerald trait (high molecular weight-kininogen deficiency) have revealed the importance of these proteins in blood coagulation. The interactions among them, however, are not fully elucidated. We have studied these reactions by two different approaches. (1) In a purified system, high molecular weight kininogen was absolutely required for activation of PTA by HF and ellagic acid (EA). The yield of activated PTA was proportional to the amount of HF, HMW-K, and PTA in the mixtures, suggesting that these three proteins may form a complex in the presence of EA. (2) In experiments with whole plasma, we took advantage of the adsorption of EA to Sephadex gels. When normal plasma or plasma deficient in HF, PK, HMW-K or PTA was exposed to Sephadex-EA and was separated by centrifugation, each supernatant plasma except that deficient in HF shortened the prolonged partial thromboplastin time (PTT) of HF-deficient plasma. Plasma simultaneously depleted of HMW-K, PK and PTA also shortened the PTT of HF-deficient plasma and of plasma depleted of HF and PK, but had virtually no procoagulant effect upon the PTT of plasma depleted of HF and MHW-K. Thus, exposure of HF in plasma to Sephadex-EA appeared to generate a clot-promoting form of HF in the absence of other clotting factors, but its expression required the presence of HMW-K.

  8. Geomorphological Hazards in Los Angeles

    NASA Astrophysics Data System (ADS)

    Hadley, Richard F.

    This is a topical book that deals with the geomorphological and geological engineering problems associated with hillslope processes and sediment transport in the Los Angeles metropolitan area. There are few large cities in the United States where the problems of urban growth include such a distinctive physical environment, as well as the potential hazards of brush fires, earthquakes, and floods that occur in Los Angeles. The research and data used in the book are restricted to Los Angeles County and cover the period 1914-1978. The author has done a commendable job of synthesizing a large mass of data from diverse sources, including federal, state, and local agency reports, plus data from private groups such as professional technical societies and consultants.

  9. Mayo de Los Capomos, Sinaloa (Mayo of Los Capomos, Sinaloa).

    ERIC Educational Resources Information Center

    Freeze, Ray A.

    This document is one of 17 volumes on indigenous Mexican languages and is the result of a project undertaken by the Archivo de Lenguas Indigenas de Mexico. This volume contains information on Mayo, an indigenous language of Mexico spoken in Los Capomos, in the state of Sinaloa. The objective of collecting such a representative sampling of the…

  10. Asymmetric Collapse of LOS Pipe.

    DTIC Science & Technology

    1980-05-26

    models that were used to simulate a LOS pipe . Still, the jet was eliminated in a Pinex model with a helical ribbon of polyolefin on the inside surface of...Target from the Pinex Model 71 with Poly Spiral in Experiment LS-3 .41 b l [ SECTION 1 *. INTRODUCTION 1.1 BACKGROUND Line-of-sight (LOS) pipes are...distance. 3.5.7 Simulation of Pinex Pipe . As shown in the photo- graphs provided in Figures 37 and 38, the Pinex-Standard Model and Pinex-Polyolefin Spiral

  11. Palace Revolt in Los Angeles?

    ERIC Educational Resources Information Center

    Fuller, Bruce

    2010-01-01

    Antonio Villaraigosa, the mayor of Los Angeles, comes alive when recalling his start in local politics--as a labor organizer agitating for reform inside decrepit and overcrowded schools. In his quest to turn around the schools, the mayor has united working-class Latino parents, civil rights leaders, and big-money Democrats to challenge union…

  12. Satellites monitor Los Alamos fires

    NASA Astrophysics Data System (ADS)

    Kalluri, Satya; White, Benjamin

    A man-made fire that was intended to be a “controlled burn” for clearing brush and wilderness at the Bandelier National Monument, New Mexico, became an inferno that devastated significant portions of Los Alamos during the first week of May 2000. Now known as the Cerro Grande fire, it was not confined to Los Alamos alone. The fire spread to 15% of the Santa Clara Indian Reservation and a substantial area of the surrounding national parks and U.S. forests.The National Weather Service estimates that more than 100,000 fires occur in the natural environment each year within the United States alone, of which about 90% are manmade. Remote sensing images from satellites could be used to detect and monitor these active fires and biomass burning. Forest fires have a significant environmental and economic impact, and timely information about their location and magnitude is essential to contain them.

  13. Los Angeles and Its Mistress Machine

    ERIC Educational Resources Information Center

    Marx, Wesley

    1973-01-01

    Los Angeles city has acute air pollution problems because of lack of an adequate mass transit system and the type of local industries. Air pollution in Los Angeles has affected agricultural production, vegetation, and public health in nearby areas. (PS)

  14. Los Alamos Science: Number 16

    SciTech Connect

    Cooper, N.G.

    1988-01-01

    It was an unusually stimulating day and a half at Los Alamos when two Nobel Laureates in physiology, a leading paleontologist, and a leading bio-astrophysicist came together to discuss ''Unsolved Problems in the Science of Life,'' the topic of the second in a series of special meetings sponsored by the Fellows of the Laboratory. Just like the first one on ''Creativity in Science,'' this colloquium took us into a broader arena of ideas and viewpoints than is our usual daily fare. To contemplate the evolution and mysteries of intelligent life from the speakers' diverse points of view at one time, in one place was indeed a rare experience.

  15. Division XII / Commission 5 / Working Group Designations

    NASA Astrophysics Data System (ADS)

    Schmitz, Marion; Andernach, Heinz J.; Borde, Suzanne; Borne, Kirk D.; Cowley, Anne P.; Dickel, Helene R.; Dubois, Pascal; Gallagher, John S.; Genova, Françoise; Hodge, Paul W.; Hunstead, Richard W.; Lortet, Marie-Claire; Lubowich, Donald A.; Malkov, Oleg Yu.; Nagata, Tetsuya; Ochsenbein, François; Urban, Sean E.; Vishniac, Ethan T.; Warren, Wayne H.; Zacharias, Norbert

    2007-12-01

    At the 2003 Sydney IAU meeting, Marion Schmitz (Caltech, USA) took over the chair of the Commission 5 Working Group Designations, succeeding Helene Dickel. The Working Group Designations of IAU Commission 5 clarifies existing astronomical nomenclature and helps astronomers avoid potential problems when designating their sources. The most important function of WG Designations during the period 2003-2005 was overseeing the IAU REGISTRY FOR ACRONYMS (for newly discovered astronomical sources of radiation: see the website ) which is sponsored by the WG and operated by the Centre de Données de Strasbourg (CDS). The Clearing House, a subgroup of the WG, screens the submissions for accuracy and conformity to the IAU Recommendations for Nomenclature (). From its beginning in 1997 through August 2006, there have been 132 submissions and 111 acceptances. Attempts to register asterisms, common star names, and suspected variable stars were rejected. The past three years saw 61 acronyms submitted with 50 of them being accepted. (GIRL - yes; WOMEN - no).

  16. Division XII: Commission 6: Astronomical Telegrams

    NASA Astrophysics Data System (ADS)

    Samus, N. N.; Yamaoka, H.; Gilmore, A. C.; Aksnes, K.; Green, D. W. E.; Marsden, B. G.; Nakano, S.; Lara, Martin; Pitjeva, Elena V.; Sphar, T.; Ticha, J.; Williams, G.

    2015-08-01

    IAU Commission 6 ``Astronomical Telegrams'' had a single business meeting during the Beijing General Assembly of the IAU. It took place on Friday, August 24, 2012. The meeting was attended by five C6 members (N. N. Samus; D. W. E. Green; S. Nakano; J. Ticha; and H. Yamaoka). Also present was Prof. F. Genova as a representative of the IAU Division B. She told the audience about the current restructuring of IAU Commissions and Divisions and consequences for the future of C6.

  17. Bruce D. Judd, FAIA, Photographer August 1997. DETAIL OF LOS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Bruce D. Judd, FAIA, Photographer August 1997. DETAIL OF LOS ANGELES CITY HALL SIXTH FLOOR NORTH OFFICE AREA WINDOW, FACING NORTHWEST - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  18. Monica Griesbach, Photographer August 1997. VIEW OF LOS ANGELES CITY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Monica Griesbach, Photographer August 1997. VIEW OF LOS ANGELES CITY HALL FIFTH FLOOR NORTH OFFICE AREA, FACING NORTH - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  19. Monica Griesbach, Photographer August 1997. DETAIL OF LOS ANGELES CITY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Monica Griesbach, Photographer August 1997. DETAIL OF LOS ANGELES CITY HALL NINETEENTH FLOOR MAIN OFFICE AREA SHOWING DEMOLITION OF WEST WALL, FACING WEST - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  20. Monica Griesbach, Photographer August 1997. VIEW OF LOS ANGELES CITY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Monica Griesbach, Photographer August 1997. VIEW OF LOS ANGELES CITY HALL NINETEENTH FLOOR MAIN OFFICE AREA, FACING NORTHEAST - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  1. Monica Griesbach, Photographer August 1997. DETAIL OF LOS ANGELES CITY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Monica Griesbach, Photographer August 1997. DETAIL OF LOS ANGELES CITY HALL NINETEENTH FLOOR MAIN OFFICE AREA SHOWING DEMOLITION OF SOUTH WALL, FACING SOUTH - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  2. Bruce D. Judd, FAIA, Photographer August 1997. VIEW OF LOS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Bruce D. Judd, FAIA, Photographer August 1997. VIEW OF LOS ANGELES CITY HALL SIXTH FLOOR NORTH OFFICE AREA, FACING NORTH - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  3. Monica Griesbach, Photographer August 1997. VIEW OF LOS ANGELES CITY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Monica Griesbach, Photographer August 1997. VIEW OF LOS ANGELES CITY HALL FIFTH FLOOR WEST OFFICE AREA THAT WAS ORIGINAL ART COMMISSION ROOMS, FACING NORTHWEST. - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  4. Monica Griesbach, Photographer August 1997. VIEW OF LOS ANGELES CITY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Monica Griesbach, Photographer August 1997. VIEW OF LOS ANGELES CITY HALL FOURTEENTH FLOOR, SERVICE AREA DOOR NEAR ELEVATOR LOBBY, FACING SOUTH - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  5. Monica Griesbach, Photographer August 1997. DETAIL OF LOS ANGELES CITY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Monica Griesbach, Photographer August 1997. DETAIL OF LOS ANGELES CITY HALL NINETEENTH FLOOR MAIN OFFICE AREA SHOWING BEAM AND COLUMN CONNECTION NEAR SOUTHEAST CORNER, FACING SOUTHEAST - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  6. Monica Griesbach, Photographer August 1997. VIEW OF LOS ANGELES CITY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Monica Griesbach, Photographer August 1997. VIEW OF LOS ANGELES CITY HALL FIFTH FLOOR WEST OFFICE AREA THAT WAS ORIGINAL ART COMMISSION ROOMS, FACING NORTHEAST - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  7. Bruce D. Judd, FAIA, Photographer August 1997. VIEW OF LOS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Bruce D. Judd, FAIA, Photographer August 1997. VIEW OF LOS ANGELES CITY HALL ELEVENTH FLOOR KITCHEN OF EXECUTIVE DINING AREA SHOWING ARCHED STRUCTURE, FACING NORTHWEST - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  8. Monica Griesbach, Photographer August 1997. DETAIL OF LOS ANGELES CITY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Monica Griesbach, Photographer August 1997. DETAIL OF LOS ANGELES CITY HALL NINETEENTH FLOOR MAIN OFFICE AREA SHOWING BEAM AND COLUMN CONNECTION NEAR NORTHWEST CORNER, FACING NORTHWEST - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  9. John Ash, AIA, Photographer August 1997. VIEW OF LOS ANGELES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    John Ash, AIA, Photographer August 1997. VIEW OF LOS ANGELES CITY HALL FIFTH FLOOR NORTH OFFICE AREA, FACING NORTHEAST - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  10. Monica Griesbach, Photographer August 1997. VIEW OF LOS ANGELES CITY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Monica Griesbach, Photographer August 1997. VIEW OF LOS ANGELES CITY HALL NINETEENTH FLOOR MAIN OFFICE AREA, FACING NORTHWEST - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  11. John Ash, AIA, Photographer August 1997. VIEW OF LOS ANGELES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    John Ash, AIA, Photographer August 1997. VIEW OF LOS ANGELES CITY HALL SEVENTH FLOOR SOUTH OFFICE AREA SHOWING STRUCTURAL PIERS AND FLORESCENT LIGHTS, FACING NORTHWEST - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  12. John Ash, AIA, Photographer August 1997. VIEW OF LOS ANGELES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    John Ash, AIA, Photographer August 1997. VIEW OF LOS ANGELES CITY HALL SEVENTH FLOOR SOUTH OFFICE AREA SHOWING WOOD AND GLASS PARTITIONS, FACING SOUTHEAST - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  13. Monica Griesbach, Photographer August 1997. VIEW OF LOS ANGELES CITY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Monica Griesbach, Photographer August 1997. VIEW OF LOS ANGELES CITY HALL FIRST FLOOR DOORS TO THE CITY CLERK AND TAX & PERMIT DIVISION OFFICES, FACING NORTH. - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  14. John Ash, AIA, Photographer August 1997. VIEW OF LOS ANGELES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    John Ash, AIA, Photographer August 1997. VIEW OF LOS ANGELES CITY HALL NINTH FLOOR NORTH OFFICE WING SHOWING PARTITIONS, WINDOWS AND RADIATOR, FACING EAST - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  15. John Ash, AIA, Photographer August 1997. DETAIL OF LOS ANGELES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    John Ash, AIA, Photographer August 1997. DETAIL OF LOS ANGELES CITY HALL SEVENTH FLOOR SOUTH OFFICE AREA SHOWING RADIATOR AND WINDOWS, FACING EAST - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  16. John Ash, AIA, Photographer August 1997. DETAIL OF LOS ANGELES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    John Ash, AIA, Photographer August 1997. DETAIL OF LOS ANGELES CITY HALL TENTH FLOOR NORTH OFFICE WING SHOWING RADIATOR AND WINDOW, FACING EAST - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  17. John Ash, ALA., Photographer August 1997. VIEW OF LOS ANGELES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    John Ash, ALA., Photographer August 1997. VIEW OF LOS ANGELES CITY HALL NINTH FLOOR NORTH OFFICE WING SHOWING PARTITIONS, WINDOWS AND RADIATOR, FACING SOUTHWEST - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  18. Monica Griesbach, Photographer August 1997. VIEW OF LOS ANGELES CITY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Monica Griesbach, Photographer August 1997. VIEW OF LOS ANGELES CITY HALL FIFTH FLOOR Y-CORRIDOR NORTH SIDE OF ELEVATOR LOBBY, FACING EAST. - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  19. Monica Griesbach, Photographer August 1997. VIEW OF LOS ANGELES CITY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Monica Griesbach, Photographer August 1997. VIEW OF LOS ANGELES CITY HALL FIFTH FLOOR Y-CORRIDOR SOUTH SIDE OF ELEVATOR LOBBY, FACING NORTHEAST. - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  20. Monica Griesbach, Photographer August 1997. VIEW OF LOS ANGELES CITY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Monica Griesbach, Photographer August 1997. VIEW OF LOS ANGELES CITY HALL FOURTEENTH FLOOR Y-CORRIDOR, FACING NORTHWEST - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  1. Monica Griesbach, Photographer August 1997. VIEW OF LOS ANGELES CITY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Monica Griesbach, Photographer August 1997. VIEW OF LOS ANGELES CITY HALL FOURTEENTH FLOOR Y-CORRIDOR NEAR ROOM 1403, FACING SOUTHWEST - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  2. Monica Griesbach, Photographer August 1997. VIEW OF LOS ANGELES CITY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Monica Griesbach, Photographer August 1997. VIEW OF LOS ANGELES CITY HALL FOURTEENTH FLOOR Y-CORRIDOR, FACING SOUTHWEST - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  3. Monica Griesbach, Photographer August 1997. VIEW OF LOS ANGELES CITY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Monica Griesbach, Photographer August 1997. VIEW OF LOS ANGELES CITY HALL FIFTH FLOOR Y-CORRIDOR SOUTH SIDE OF ELEVATOR LOBBY, FACING WEST - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  4. John Ash, AIA, Photographer August 1997. VIEW OF LOS ANGELES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    John Ash, AIA, Photographer August 1997. VIEW OF LOS ANGELES CITY HALL TENTH FLOOR SOUTH WING CAFETERIA FOOD LINE, FACING NORTH - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  5. Monica Griesbach, Photographer August 1997. VIEW OF LOS ANGELES CITY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Monica Griesbach, Photographer August 1997. VIEW OF LOS ANGELES CITY HALL FIFTH FLOOR BREAK ROOM OFF OF ORIGINAL ART COMMISSION ROOMS, FACING NORTHEAST - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  6. Monica Griesbach, Photographer August 1997. VIEW OF LOS ANGELES CITY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Monica Griesbach, Photographer August 1997. VIEW OF LOS ANGELES CITY HALL FIFTH FLOOR BREAK ROOM OFF OF ORIGINAL ART COMMISSION ROOMS, FACING SOUTHEAST - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  7. Monica Griesbach, Photographer August 1997. DETAIL OF LOS ANGELES CITY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Monica Griesbach, Photographer August 1997. DETAIL OF LOS ANGELES CITY HALL WEST ENTRANCE COURTYARD SHOWING BRONZE DOORS, LIGHT FIXTURES AND GRILLS, FACING EAST. - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  8. Monica Griesbach, Photographer August 1997. DETAIL OF LOS ANGELES CITY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Monica Griesbach, Photographer August 1997. DETAIL OF LOS ANGELES CITY HALL WEST ENTRANCE COURTYARD SHOWING BRONZE DOORS AND HANDRAILS, FACING EAST. - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  9. Monica Griesbach, Photographer August 1997. DETAIL OF LOS ANGELES CITY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Monica Griesbach, Photographer August 1997. DETAIL OF LOS ANGELES CITY HALL WEST ENTRANCE COURTYARD SHOWING FLOORING, COLUMNS AND BRONZE DOORS, FACING EAST. - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  10. John Ash, AIA, Photographer August 1997. DETAIL OF LOS ANGELES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    John Ash, AIA, Photographer August 1997. DETAIL OF LOS ANGELES CITY HALL TWENTY-SEVENTH FLOOR WEST EXTERIOR GALLERY SOUTHEAST STAIR TO PYRAMID, FACING SOUTH - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

  11. Los Alamos PC estimating system

    SciTech Connect

    Stutz, R.A.; Lemon, G.D.

    1987-01-01

    The Los Alamos Cost Estimating System (QUEST) is being converted to run on IBM personal computers. This very extensive estimating system is capable of supporting cost estimators from many different and varied fields. QUEST does not dictate any fixed method for estimating. QUEST supports many styles and levels of detail estimating. QUEST can be used with or without data bases. This system allows the estimator to provide reports based on levels of detail defined by combining work breakdown structures. QUEST provides a set of tools for doing any type of estimate without forcing the estimator to use any given method. The level of detail in the estimate can be mixed based on the amount of information known about different parts of the project. The system can support many different data bases simultaneously. Estimators can modify any cost in any data base.

  12. Trouble Brewing in Los Angeles. Policy Brief

    ERIC Educational Resources Information Center

    Buck, Stuart

    2010-01-01

    The city of Los Angeles will face enormous budgetary pressures from the growing deficits in public pensions, both at a state and local level. In this policy brief, the author estimates that Los Angeles faces a total $152.6 billion liability for pensions that are underfunded--including $49.1 billion for the city pension systems, $2.4 billion for…

  13. Los Alamos Laser Eye Investigation.

    SciTech Connect

    Odom, C. R.

    2005-01-01

    A student working in a laser laboratory at Los Alamos National Laboratory sustained a serious retinal injury to her left eye when she attempted to view suspended particles in a partially evacuated target chamber. The principle investigator was using the white light from the flash lamp of a Class 4 Nd:YAG laser to illuminate the particles. Since the Q-switch was thought to be disabled at the time of the accident, the principal investigator assumed it would be safe to view the particles without wearing laser eye protection. The Laboratory Director appointed a team to investigate the accident and to report back to him the events and conditions leading up to the accident, equipment malfunctions, safety management causal factors, supervisory and management action/inaction, adequacy of institutional processes and procedures, emergency and notification response, effectiveness of corrective actions and lessons learned from previous similar events, and recommendations for human and institutional safety improvements. The team interviewed personnel, reviewed documents, and characterized systems and conditions in the laser laboratory during an intense six week investigation. The team determined that the direct and primary failures leading to this accident were, respectively, the principle investigator's unsafe work practices and the institution's inadequate monitoring of worker performance. This paper describes the details of the investigation, the human and institutional failures, and the recommendations for improving the laser safety program.

  14. Los Alamos Neutron Science Center

    SciTech Connect

    Kippen, Karen Elizabeth

    2016-11-08

    For more than 30 years the Los Alamos Neutron Science Center (LANSCE) has provided the scientific underpinnings in nuclear physics and material science needed to ensure the safety and surety of the nuclear stockpile into the future. In addition to national security research, the LANSCE User Facility has a vibrant research program in fundamental science, providing the scientific community with intense sources of neutrons and protons to perform experiments supporting civilian research and the production of medical and research isotopes. Five major experimental facilities operate simultaneously. These facilities contribute to the stockpile stewardship program, produce radionuclides for medical testing, and provide a venue for industrial users to irradiate and test electronics. In addition, they perform fundamental research in nuclear physics, nuclear astrophysics, materials science, and many other areas. The LANSCE User Program plays a key role in training the next generation of top scientists and in attracting the best graduate students, postdoctoral researchers, and early-career scientists. The U.S. Department of Energy (DOE), National Nuclear Security Administration (NNSA) —the principal sponsor of LANSCE—works with the Office of Science and the Office of Nuclear Energy, which have synergistic long-term needs for the linear accelerator and the neutron science that is the heart of LANSCE.

  15. 9. NORTHSIDE OF HYPERION BOULEVARD VIADUCT OVERCROSSING OF LOS ANGELES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. NORTHSIDE OF HYPERION BOULEVARD VIADUCT OVERCROSSING OF LOS ANGELES RIVER. LOOKING EAST/SOUTHEAST. HYPERION BOULEVARD OVERCROSSING OF LOS ANGELES RIVER IS UPPER SECTION OF VIADUCT. GLENDALE BOULEVARD IS LOWER SECTION OF RIVER OVERCROSSING. - Glendale-Hyperion Viaduct, Spanning Golden State Freeway (I-5) & Los Angeles River at Glendale Boulevard, Los Angeles, Los Angeles County, CA

  16. 2. LEE VINING INTAKE, MONO LAKE IN BACKGROUND. Los ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. LEE VINING INTAKE, MONO LAKE IN BACKGROUND. - Los Angeles Aqueduct, From Lee Vining Intake (Mammoth Lakes) to Van Norman Reservoir Complex (San Fernando Valley), Los Angeles, Los Angeles County, CA

  17. 40. PLEASANT VALLEY RESERVOIR DAM LOOKING NORTHWEST Los Angeles ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    40. PLEASANT VALLEY RESERVOIR DAM LOOKING NORTHWEST - Los Angeles Aqueduct, From Lee Vining Intake (Mammoth Lakes) to Van Norman Reservoir Complex (San Fernando Valley), Los Angeles, Los Angeles County, CA

  18. 47. LINED SECTION OF AQUEDUCT LOOKING NORTHWEST, COTTONWOOD Los ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    47. LINED SECTION OF AQUEDUCT LOOKING NORTHWEST, COTTONWOOD - Los Angeles Aqueduct, From Lee Vining Intake (Mammoth Lakes) to Van Norman Reservoir Complex (San Fernando Valley), Los Angeles, Los Angeles County, CA

  19. 82. FIRST AND SECOND AQUEDUCTS LOOKING NORTHEAST Los Angeles ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    82. FIRST AND SECOND AQUEDUCTS LOOKING NORTHEAST - Los Angeles Aqueduct, From Lee Vining Intake (Mammoth Lakes) to Van Norman Reservoir Complex (San Fernando Valley), Los Angeles, Los Angeles County, CA

  20. 87. AQUEDUCT IN COVERED CONDUIT LOOKING NORTHWEST Los Angeles ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    87. AQUEDUCT IN COVERED CONDUIT LOOKING NORTHWEST - Los Angeles Aqueduct, From Lee Vining Intake (Mammoth Lakes) to Van Norman Reservoir Complex (San Fernando Valley), Los Angeles, Los Angeles County, CA

  1. 84. LA AQUEDUCT CROSSING CALIFORNIA AQUEDUCT LOOKING NORTH Los ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    84. LA AQUEDUCT CROSSING CALIFORNIA AQUEDUCT LOOKING NORTH - Los Angeles Aqueduct, From Lee Vining Intake (Mammoth Lakes) to Van Norman Reservoir Complex (San Fernando Valley), Los Angeles, Los Angeles County, CA

  2. 78. SECOND AQUEDUCT LOOKING SOUTH NEAR PINETREE SIPHON Los ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    78. SECOND AQUEDUCT LOOKING SOUTH NEAR PINETREE SIPHON - Los Angeles Aqueduct, From Lee Vining Intake (Mammoth Lakes) to Van Norman Reservoir Complex (San Fernando Valley), Los Angeles, Los Angeles County, CA

  3. Publications of Los Alamos research 1988

    SciTech Connect

    Varjabedian, K.; Dussart, S.A.; McClary, W.J.; Rich, J.A.

    1989-12-01

    This bibliography lists unclassified publications of work done at the Los Alamos National Laboratory for 1988. The entries, which are subdivided by broad subject categories, are cross-referenced with an author index and a numeric index.

  4. Environmental surveillance at Los Alamos during 1994

    SciTech Connect

    1996-07-01

    This report describes environmental monitoring activities at Los Alamos National Laboratory for 1994. Data were collected to assess external penetrating radiation, airborne emissions, liquid effluents, radioactivity of environmental materials and food stuffs, and environmental compliance.

  5. New Rad Lab for Los Alamos

    ScienceCinema

    None

    2016-07-12

    The topping out ceremony for a key construction stage in the Los Alamos National Laboratory's newest facility, the Radiological Laboratory Utility & Office Building. This is part of the National Nu...  

  6. New Rad Lab for Los Alamos

    SciTech Connect

    2008-08-06

    The topping out ceremony for a key construction stage in the Los Alamos National Laboratory's newest facility, the Radiological Laboratory Utility & Office Building. This is part of the National Nu...  

  7. Shuttle Endeavour Flyover of Los Angeles Landmarks

    NASA Video Gallery

    Space shuttle Endeavour atop NASA's Shuttle Carrier Aircraft flew over many Los Angeles area landmarks on its final ferry flight Sept. 21, 2012, including the Coliseum, the Hollywood Sign, Griffith...

  8. Edward Teller Returns to LOS Alamos

    NASA Astrophysics Data System (ADS)

    Hecker, Siegfried S.

    2010-01-01

    I was asked to share some reflections of Edward Teller's return to Los Alamos during my directorship. I met Teller late in his life. My comments focus on that time and they will be mostly in the form of stories of my interactions and those of my colleagues with Teller. Although the focus of this symposium is on Teller's contributions to science, at Los Alamos it was never possible to separate Teller's science from policy and controversy ...

  9. Internship at Los Alamos National Laboratory

    SciTech Connect

    Dunham, Ryan Q.

    2012-07-11

    Los Alamos National Laboratory (LANL) is located in Los Alamos, New Mexico. It provides support for our country's nuclear weapon stockpile as well as many other scientific research projects. I am an Undergraduate Student Intern in the Systems Design and Analysis group within the Nuclear Nonproliferation division of the Global Security directorate at LANL. I have been tasked with data analysis and modeling of particles in a fluidized bed system for the capture of carbon dioxide from power plant flue gas.

  10. La masa de los grandes impactores

    NASA Astrophysics Data System (ADS)

    Parisi, M. G.; Brunini, A.

    Los planetas han sido formados fundamentalmente acretando masa a través de colisiones con planetesimales sólidos. La masa más grande de la distribución de planetesimales y las masas máxima y mínima de los impactores, han sido calculadas usando los valores actuales del período y de la inclinación de los planetas (Lissauer & Safronov 1991; Parisi & Brunini 1996). Recientes investigaciones han mostrado, que las órbitas de los planetas gigantes no han sufrido variaciones con el tiempo, siendo su movimiento regular durante su evolución a partir de la finalización de la etapa de acreción (Laskar 1990, 1994). Por lo tanto, la eccentricidad actual de los planetas gigantes se puede utilizar para imponer una cota máxima a las masas y velocidades orbitales de los grandes impactores. Mediante un simple modelo dinámico, y considerando lo arriba mencionado, obtenemos la cota superior para la masa del planetesimal más grande que impactó a cada planeta gigante al final de su etapa de acreción. El resultado más importante de este trabajo es la estimación de la masa máxima permitida para impactar a Júpiter, la cúal es ~ 1.136 × 10 -1, siendo en el caso de Neptuno ~ 3.99 × 10 -2 (expresada en unidades de la masa final de cada planeta). Además, fue posible obtener la velocidad orbital máxima permitida para los impactores como una función de su masa, para cada planeta. Las cotas obtenidas para la masa y velocidad de los impactores de Saturno y Urano (en unidades de la masa y velocidad final de cada planeta respectivamente) son casi las mismas que las obtenidas para Júpiter debido a que estos tres planetas poseen similar eccentricidad actual. Nuestros resultados están en buen acuerdo con los obtenidos por Lissauer & Safronov (1991). Estas cotas podrían ser utilizadas para obtener la distribución de planetesimales en el Sistema Solar primitivo.

  11. Los Angeles Community Colleges Student Characteristics, Fall 1997.

    ERIC Educational Resources Information Center

    Tillberg, Rebecca; Crespo, Sarah P.; Lagrimas, Joseph

    This report documents Los Angeles Community Colleges' student characteristics. It begins with a glossary providing specific definitions for the student characteristic criteria. Descriptive summaries and tables of student characteristic data are provided for the Los Angeles Community College District, Los Angeles City College, East Los Angeles…

  12. Status of Monte Carlo at Los Alamos

    SciTech Connect

    Thompson, W.L.; Cashwell, E.D.

    1980-01-01

    At Los Alamos the early work of Fermi, von Neumann, and Ulam has been developed and supplemented by many followers, notably Cashwell and Everett, and the main product today is the continuous-energy, general-purpose, generalized-geometry, time-dependent, coupled neutron-photon transport code called MCNP. The Los Alamos Monte Carlo research and development effort is concentrated in Group X-6. MCNP treats an arbitrary three-dimensional configuration of arbitrary materials in geometric cells bounded by first- and second-degree surfaces and some fourth-degree surfaces (elliptical tori). Monte Carlo has evolved into perhaps the main method for radiation transport calculations at Los Alamos. MCNP is used in every technical division at the Laboratory by over 130 users about 600 times a month accounting for nearly 200 hours of CDC-7600 time.

  13. Publications of Los Alamos research 1980

    SciTech Connect

    Salazar, C.A.; Willis, J.K.

    1981-09-01

    This bibliography is a compilation of unclassified publications of work done at the Los Alamos National Laboratory for 1980. Papers published in 1980 are included regardless of when they were actually written. Publications received too late for inclusion in earlier compilations have also been listed. Declassification of previously classified reports is considered to constitute publication. All classified issuances are omitted-even those papers, themselves unclassified, which were published only as part of a classified document. If a paper was pubished more than once, all places of publication are included. The bibliography includes Los Alamos National Laboratory reports, papers released as non-laboratory reports, journal articles, books, chapters of books, conference papers published either separately or as part of conference proceedings issued as books or reports, papers published in congressional hearings, theses, and US patents. Publications by Los Alamos authors that are not records of Laboratory-sponsored work are included when the Library becomes aware of them.

  14. Publications of Los Alamos Research, 1983

    SciTech Connect

    Sheridan, C.J.; McClary, W.J.; Rich, J.A.; Rodriguez, L.L.

    1984-10-01

    This bibliography is a compilation of unclassified publications of work done at the Los Alamos National Laboratory for 1983. Papers published in 1982 are included regardless of when they were actually written. Publications received too late for inclusion in earlier compilations have also been listed. Declassification of previously classified reports is considered to constitute publication. All classified issuances are omitted - even those papers, themselves unclassified, which were published only as part of a classified document. If a paper was published more than once, all places of publication are included. The bibliography includes Los Alamos National Laboratory reports, papers released as non-Laboratory reports, journal articles, books, chapters of books, conference papers either published separately or as part of conference proceedings issued as books or reports, papers publishd in congressional hearings, theses, and US patents. Publications by Los Alamos authors that are not records of Laboratory-sponsored work are included when the Library becomes aware of them.

  15. Programas de Educacion Inicial en America Latina y los Curriculos Nacionales en el siglo XXI. [Latin American Early Childhood Educational Programs and National Curriculum in the 21st Century.

    ERIC Educational Resources Information Center

    Peralta, Maria Victoria

    2003-01-01

    Describes the history of early childhood education in Chile and recent educational reforms. Offers an overview of the Chilean Early Childhood Education program and discusses the new national curriculum and issues arising from its implementation. Describes methods taken to help implement the new curriculum nationwide and to assist teachers in…

  16. Induction inserts at the Los Alamos PSR

    SciTech Connect

    King-Yuen Ng

    2002-09-30

    Ferrite-loaded induction tuners installed in the Los Alamos Proton Storage Ring have been successful in compensating space-charge effects. However, the resistive part of the ferrite introduces unacceptable microwave instability and severe bunch lengthening. An effective cure was found by heating the ferrite cores up to {approx} 130 C. An understanding of the instability and cure is presented.

  17. Significant Silence in Elena Garro's "Los Perros"

    ERIC Educational Resources Information Center

    Burke, Jessica

    2010-01-01

    Elena Garro's one-act play "Los perros" (1958) confronts the difficult issue of sexual violence in rural Mexico, a problem that persists today. The characters struggle with the social reality of rape, alluding to the threat of sexual violence while avoiding addressing it directly. While words are granted an almost magical power in…

  18. Small mammals from Sima de los Huesos.

    PubMed

    Cuenca-Bescós, G; Laplana Conesa, C; Canudo, J I; Arsuaga, J L

    1997-01-01

    A small collection of rodents from Sima de los Huesos helps to clarify the stratigraphic position of this famous human locality. The presence of Allocricetus bursae and Pliomys lenki relictus and the size of A. bursae, Apodemus sylvaticus and Eliomys quercinus suggest a Middle Pleistocene age (Saalian) to the Clays where humans have been found.

  19. Race, Reading, and Proverty in Los Angeles

    ERIC Educational Resources Information Center

    Payne, Joseph F.

    1971-01-01

    Correlation analysis of reading score rankings of all the elementary, unified, and high school districts in Los Angeles County discloses a strong negative relation between proportion of minority students and rank, and proportion of students receiving welfare aid and rank. (JM)

  20. New Management Thrust at Los Rios

    ERIC Educational Resources Information Center

    Klapstein, Earl L.

    1978-01-01

    Describes the management practices adopted by the Los Rios Community College District (California) as a result of the passage of the Jarvis-Gann tax initiative. Alterations included reorganization of upper management structure, full budget disclosures, collective bargaining, merit pay concept for administrative staff, and the creation of a…

  1. Los Angeles County Parks and Recreation.

    ERIC Educational Resources Information Center

    Iowa Univ., Iowa City. Recreation Education Program.

    Presented are duplications of the responses given by the Los Angeles County Parks and Recreation Rehabilitation Unit (California) as part of a project to collect, share, and compile information about, and techniques in the operation of 18 community action models for recreation services to the disabled. Model programs are categorized as consumer,…

  2. Los Angeles Settles ACLU Suit on Layoffs

    ERIC Educational Resources Information Center

    Sawchuk, Stephen

    2010-01-01

    A settlement crafted last week seeking to curb the use of seniority as a factor in teacher layoffs in the Los Angeles school system could become one of the nation's most far-reaching overhauls of the "last hired, first fired" policies common in school districts. If approved by a judge, the settlement would shield up to 45 low-performing…

  3. A Sailor in the Los Alamos Navy

    SciTech Connect

    Judd, D. L.

    2016-12-20

    As part of the War Department’s Manhattan Engineer District (MED), Los Alamos was an Army installation during World War II, complete with a base commander and a brace of MPs. But it was a unique Army installation, having more civilian then military personnel. Even more unique was the work performed by the civilian population, work that required highly educated scientists and engineers. As the breadth, scope, and complexity of the Laboratory’s work increased, more and more technically educated and trained personnel were needed. But, the manpower needs of the nation’s war economy had created a shortage of such people. To meet its manpower needs, the MED scoured the ranks of the Army for anyone who had technical training and reassigned these men to its laboratories, including Los Alamos, as part of its Special Engineer Detachment (SED). Among the SEDs assigned to Los Alamos was Val Fitch, who was awarded the Nobel Prize in Physics in 1980. Another was Al Van Vessem, who helped stack the TNT for the 100 ton test, bolted together the Trinity device, and rode shotgun with the bomb has it was driven from Los Alamos to ground zero.

  4. Latina Adolescent Childbearing in East Los Angeles.

    ERIC Educational Resources Information Center

    Erickson, Pamela I.

    This book is about teenage pregnancy among Latina teenagers in East Los Angeles (California). It focuses on teenage pregnancy and motherhood among economically disadvantaged Latinas aged 17 and under. The young mothers in this study were participants in a series of intervention efforts to prevent repeat pregnancy at a family planning clinic. This…

  5. Minorities in Suburbs: The Los Angeles Experience.

    ERIC Educational Resources Information Center

    Rabinovitz, Francine F.; Siembieda, William J.

    This book focuses on black suburbanization in the Los Angeles area, and questions whether the national increase in black suburbanization should be viewed with optimism or pessimism. The study addresses three questions: (1) Does the presence of substantial black populations in suburban areas represent suburbanization as it is normally thought of,…

  6. Recent Infrasound Calibration Activity at Los Alamos

    NASA Astrophysics Data System (ADS)

    Whitaker, R. W.; Marcillo, O. E.

    2014-12-01

    Absolute infrasound sensor calibration is necessary for estimating source sizes from measured waveforms. This can be an important function in treaty monitoring. The Los Alamos infrasound calibration chamber is capable of absolute calibration. Early in 2014 the Los Alamos infrasound calibration chamber resumed operations in its new location after an unplanned move two years earlier. The chamber has two sources of calibration signals. The first is the original mechanical piston, and the second is a CLD Dynamics Model 316 electro-mechanical unit that can be digitally controlled and provide a richer set of calibration options. During 2008-2010 a number of upgrades were incorporated for improved operation and recording. In this poster we give an overview of recent chamber work on sensor calibrations, calibration with the CLD unit, some measurements with different porous hoses and work with impulse sources.

  7. Nuclear Forensics at Los Alamos National Laboratory

    SciTech Connect

    Podlesak, David W; Steiner, Robert E.; Burns, Carol J.; LaMont, Stephen P.; Tandon, Lav

    2012-08-09

    The overview of this presentation is: (1) Introduction to nonproliferation efforts; (2) Scope of activities at Los Alamos National Laboratory; (3) Facilities for radioanalytical work at LANL; (4) Radiochemical characterization capabilities; and (5) Bulk chemical and materials analysis capabilities. Some conclusions are: (1) Analytical chemistry measurements on plutonium and uranium matrices are critical to numerous defense and non-defense programs including safeguards accountancy verification measurements; (2) Los Alamos National Laboratory operates capable actinide analytical chemistry and material science laboratories suitable for nuclear material forensic characterization; (3) Actinide analytical chemistry uses numerous means to validate and independently verify that measurement data quality objectives are met; and (4) Numerous LANL nuclear facilities support the nuclear material handling, preparation, and analysis capabilities necessary to evaluate samples containing nearly any mass of an actinide (attogram to kilogram levels).

  8. Facilitating LOS Debriefings: A Training Manual

    NASA Technical Reports Server (NTRS)

    McDonnell, Lori K.; Jobe, Kimberly K.; Dismukes, R. Key

    1997-01-01

    This manual is a practical guide to help airline instructors effectively facilitate debriefings of Line Oriented Simulations (LOS). It is based on a recently completed study of Line Oriented Flight Training (LOFT) debriefings at several U.S. airlines. This manual presents specific facilitation tools instructors can use to achieve debriefing objectives. The approach of the manual is to be flexible so it can be tailored to the individual needs of each airline. Part One clarifies the purpose and objectives of facilitation in the LOS setting. Part Two provides recommendations for clarifying roles and expectations and presents a model for organizing discussion. Part Tree suggests techniques for eliciting active crew participation and in-depth analysis and evaluation. Finally, in Part Four, these techniques are organized according to the facilitation model. Examples of how to effectively use the techniques are provided throughout, including strategies to try when the debriefing objectives are not being fully achieved.

  9. Water Supply at Los Alamos during 1997

    SciTech Connect

    M. N. Maes; S. G. McLin; W. D. Purtymun

    1998-12-01

    Production of potable municipal water supplies during 1997 totaled about 1,285.9 million gallons from wells in the Guaje, Pajarito, and Otowi well fields. There was no water used from the spring gallery in Water Canyon or from Guaje Reservoir during 1997. About 2.4 million gallons of water from Los Alamos Reservoir was used to irrigate public parks and recreational lands. The total water usage in 1997 was about 1,288.3 million gallons, or about 135 gallons per day per person living in Los Alamos County. Groundwater pumpage was down about 82.2 million gallons in 1997 compared with the pumpage in 1996. Four new replacement wells were drilled and cased in Guaje Canyon between October 1997 and March 1998. These wells are currently being developed and aquifer tests are being performed. A special report summarizing the geological, geophysical, and well construction logs will be issued in the near future for these new wells.

  10. Water supply at Los Alamos during 1992

    SciTech Connect

    Purtymun, W.D.; McLin, S.G.; Stoker, A.K.; Maes, M.N.

    1995-09-01

    Municipal potable water supply during 1992 was 1,516 {times} 10{sup 6} gallons from wells in the Guaje and Pajarito well fields. About 13 {times} 10{sup 6} gallons were pumped from the Los Alamos Well Field and used in the construction of State Road 501 adjacent to the Field. The last year the Las Alamos Field was used for municipal supply was 1991. The nonpotable water supply used for steam plant support was about 0.12 {times} 10{sup 6} gallons from the spring gallery in Water Canyon. No nonpotable water was used for irrigation from Guaje and Los Alamos Reservoirs. Thus, the total water usage in 1992 was about 1,529 {times} 10{sup 6} gallons. Neither of the two new wells in the Otowi Well Field were operational in 1992.

  11. Los Alamos Novel Rocket Design Flight Tested

    ScienceCinema

    Tappan, Bryce

    2016-07-12

    Los Alamos National Laboratory scientists recently flight tested a new rocket design that includes a high-energy fuel and a motor design that also delivers a high degree of safety. Researchers will now work to scale-up the design, as well as explore miniaturization of the system, in order to exploit all potential applications that would require high-energy, high-velocity, and correspondingly high safety margins.

  12. Risk management at Los Alamos National Laboratory

    SciTech Connect

    Brooks, D.G.; Stack, D.W.

    1993-11-01

    Los Alamos National Laboratory has risk management programs at a number of administrative levels. Each line organization has responsibility for risk management for routine operations. The Facility Risk Management group (HS-3) is the Los Alamos organization with the primary responsibility for risk management including providing input and expertise to facilities and line managers in the management and documentation of ES&H hazards and risks associated with existing and new activities. One of the major contributions this group has made to laboratory risk management program is to develop and implement a hazard identification and classification methodology that is readily adaptable to continuously changing classification guidelines such as DOE-STD-1027. The increased emphasis on safety at Los Alamos has led to the formation of additional safety oversight organization such as the Integration and Coordination Office (ICO), which is responsible for prioritization of risk management activities. In the fall of 1991, nearly 170 DOE inspectors spent 6 weeks analyzing the environmental, safety, and health activities at Los Alamos. The result of this audit was a list of over 1000 findings, each indicating some deficiency in current Laboratory operations relative to DOE and other government regulation. The audit team`s findings were consolidated and ``action plans`` were developed to address the findings. This resulted in over 200 action plans with a total estimated cost of almost $1 billion. The Laboratory adopted a risk-based prioritization process to attempt to achieve as much risk reduction as possible with the available resources. This paper describes the risk based prioritization model that was developed.

  13. Los Alamos National Laboratory Facility Review

    SciTech Connect

    Nelson, Ronald Owen

    2015-06-05

    This series of slides depicts the Los Alamos Neutron Science Center (LANSCE). The Center's 800-MeV linac produces H+ and H- beams as well as beams of moderated (cold to 1 MeV) and unmoderated (0.1 to 600 MeV) neutrons. Experimental facilities and their capabilities and characteristics are outlined. Among these are LENZ, SPIDER, and DANCE.

  14. Los Alamos Team Demonstrates Bottle Scanner Technology

    SciTech Connect

    Espy, Michelle; Schultz, Larry

    2014-05-06

    Los Alamos scientists are demonstrating a Nuclear Magnetic Resonance Imaging (NMR) technology that may provide a breakthrough for screening liquids at airport security. By adding low-power X-ray data to the NMR mix, scientists believe they have unlocked a new detection technology. Funded in part by the Department of Homeland Security's Science and Technology Directorate, the new technology is called MagRay.

  15. Los Alamos Team Demonstrates Bottle Scanner Technology

    ScienceCinema

    Espy, Michelle; Schultz, Larry

    2016-07-12

    Los Alamos scientists are demonstrating a Nuclear Magnetic Resonance Imaging (NMR) technology that may provide a breakthrough for screening liquids at airport security. By adding low-power X-ray data to the NMR mix, scientists believe they have unlocked a new detection technology. Funded in part by the Department of Homeland Security's Science and Technology Directorate, the new technology is called MagRay.

  16. Amphibians and Reptiles of Los Alamos County

    SciTech Connect

    Teralene S. Foxx; Timothy K. Haarmann; David C. Keller

    1999-10-01

    Recent studies have shown that amphibians and reptiles are good indicators of environmental health. They live in terrestrial and aquatic environments and are often the first animals to be affected by environmental change. This publication provides baseline information about amphibians and reptiles that are present on the Pajarito Plateau. Ten years of data collection and observations by researchers at Los Alamos National Laboratory, the University of New Mexico, the New Mexico Department of Game and Fish, and hobbyists are represented.

  17. Los Alamos Novel Rocket Design Flight Tested

    SciTech Connect

    Tappan, Bryce

    2014-10-23

    Los Alamos National Laboratory scientists recently flight tested a new rocket design that includes a high-energy fuel and a motor design that also delivers a high degree of safety. Researchers will now work to scale-up the design, as well as explore miniaturization of the system, in order to exploit all potential applications that would require high-energy, high-velocity, and correspondingly high safety margins.

  18. Status of the Los Almos Anger camera

    NASA Astrophysics Data System (ADS)

    Seeger, P. A.; Nutter, M. J.

    Results of preliminary tests of the neutron Anger camera being developed at Los Alamos are presented. This detector uses a unique encoding scheme involving parallel processing of multiple receptive fields. Design goals have not yet been met, but the results are very encouraging and improvements in the test procedures are expected to show that the detector will be ready for use on a small-angle scattering instrument next year.

  19. 76 FR 13017 - Environmental Impact Statement: Los Angeles County, CA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-09

    ... Federal Highway Administration Environmental Impact Statement: Los Angeles County, CA AGENCY: Federal... Environmental Impact Statement will be prepared for a proposed highway project in Los Angeles County, California... District Director, California Department of Transportation, District 7, Division of Environmental...

  20. Los Angeles County Poor Farm, Patient Wards 201, 202, 203, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Los Angeles County Poor Farm, Patient Wards 201, 202, 203, 204, 205, 206, 207, 208 & 209 - Type A Plan, 7601 Imperial Highway; bounded by Esperanza Street, Hawthorn Avenue, Laurel Street, and Descanso Street, Downey, Los Angeles County, CA

  1. Los Angeles County Poor Farm, Patient Ward Nos. 210 & ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Los Angeles County Poor Farm, Patient Ward Nos. 210 & 211 - Type B Plan, 7601 Imperial Highway; bounded by Esperanza Street, Laurel Street, Flores Street, and Descanso Street, Downey, Los Angeles County, CA

  2. Critical partnerships: Los Alamos, universities, and industry

    SciTech Connect

    Berger, C.L.

    1997-04-01

    Los Alamos National Laboratory, situated 35 miles northwest of Santa Fe, NM, is one of the Department of Energy`s three Defense Programs laboratories. It encompasses 43 square miles, employees approximately 10,000 people, and has a budget of approximately $1.1B in FY97. Los Alamos has a strong post-cold war mission, that of reducing the nuclear danger. But even with that key role in maintaining the nation`s security, Los Alamos views partnerships with universities and industry as critical to its future well being. Why is that? As the federal budget for R&D comes under continued scrutiny and certain reduction, we believe that the triad of science and technology contributors to the national system of R&D must rely on and leverage each others capabilities. For us this means that we will rely on these partners to help us in 5 key ways: We expect that partnerships will help us maintain and enhance our core competencies. In doing so, we will be able to attract the best scientists and engineers. To keep on the cutting edge of research and development, we have found that partnerships maintain the excellence of staff through new and exciting challenges. Additionally, we find that from our university and corporate partners we often learn and incorporate {open_quotes}best practices{close_quotes} in organizational management and operations. Finally, we believe that a strong national system of R&D will ensure and enhance our ability to generate revenues.

  3. Space Radar Image of Los Angeles, California

    NASA Technical Reports Server (NTRS)

    1994-01-01

    This radar image shows the massive urbanization of Los Angeles, California. The image extends from the Santa Monica Bay at the left to the San Gabriel Mountains at the right. Downtown Los Angeles is in the center of the image. The runways of the Los Angeles International Airport appear as black strips at the left center of the image. The waterways of Marina del Rey are seen just above the airport. The San Gabriel Mountains and the city of Pasadena are at the right center of the image. Black areas on the mountains on the right are fire scars from the 1993 Altadena fire. The Rose Bowl is shown as a small circle near the right center. The complex freeway system is visible as dark lines throughout the image. Some city areas, such as Santa Monica in the upper left, appear red due to the alignment of streets and buildings to the incoming radar beam. The image was acquired by the Spaceborne Imaging Radar-C/X-band Synthetic Aperture Radar (SIR-C/X-SAR) onboard the space shuttle Endeavour on October 3, 1994. SIR-C/X-SAR, a joint mission of the German, Italian and the United States space agencies, is part of NASA's Mission to Planet Earth. This image is centered at 34.04 degrees North latitude and 118.2 degrees West longitude with North pointing toward the upper right. The area shown measures 40 kilometers by 50 kilometers (25 miles by 31 miles).

  4. Los Alamos National Laboratory Building Cost Index

    SciTech Connect

    Orr, H.D.; Lemon, G.D.

    1983-01-01

    The Los Alamos National Laboratory Building Cost Index indicates that actual escalation since 1970 is near 10% per year. Therefore, the Laboratory will continue using a 10% per year escalation rate for construction estimates through 1985 and a slightly lower rate of 8% per year from 1986 through 1990. The computerized program compares the different elements involved in the cost of a typical construction project, which for our purposes, is a complex of office buildings and experimental laboratores. The input data used in the program consist primarily of labor costs and material and equipment costs. The labor costs are the contractural rates of the crafts workers in the Los Alamos area. For the analysis, 12 field-labor draft categories are used; each is weighted corresponding to the labor craft distribution associated with the typical construction project. The materials costs are current Los Alamos prices. Additional information sources include material and equipment quotes obtained through conversations with vendors and from trade publications. The material and equipment items separate into 17 categories for the analysis and are weighted corresponding to the material and equipment distribution associated with the typical construction project. The building cost index is compared to other national building cost indexes.

  5. Los Alamos National Laboratory building cost index

    SciTech Connect

    Orr, H.D.; Lemon, G.D.

    1982-10-01

    The Los Alamos National Laboratory Building Cost Index indicates that actual escalation since 1970 is near 10% per year. Therefore, the Laboratory will continue using a 10% per year escalation rate for construction estimates through 1985 and a slightly lower rate of 8% per year from 1986 through 1990. The computerized program compares the different elements involved in the cost of a typical construction project, which for our purposes, is a complex of office buildings and experimental laboratories. The input data used in the program consist primarily of labor costs and material and equipment costs. The labor costs are the contractual rates of the crafts workers in the Los Alamos area. For the analysis, 12 field-labor craft categories are used; each is weighted corresponding to the labor craft distribution associated with the typical construction project. The materials costs are current Los Alamos prices. Additional information sources include material and equipment quotes obtained through conversations with vendors and from trade publications. The material and equipment items separate into 17 categories for the analysis and are weighted corresponding to the material and equipment distribution associated with the typical construction project. The building cost index is compared to other national building cost indexes.

  6. Space Radar Image of Los Angeles, California

    NASA Technical Reports Server (NTRS)

    1994-01-01

    This is a radar image of Los Angeles, California, taken on October 2, 1994. Visible in the image are Long Beach Harbor at the bottom right (south corner of the image), Los Angeles International Airport at the bottom center, with Santa Monica just to the left of it and the Hollywood Hills to the left of Santa Monica. Also visible in the image are the freeway systems of Los Angeles, which appear as dark lines. The San Gabriel Mountains (center top) and the communities of San Fernando Valley, Simi Valley and Palmdale can be seen on the left-hand side. This image was acquired by the Spaceborne Imaging Radar-C and X-band Synthetic Aperture Radar (SIR-C/X-SAR) aboard the space shuttle Endeavour on its 24th orbit. The image is centered at 34 degrees north latitude, 118 degrees west longitude. The area shown is approximately 100 kilometers by 52 kilometers (62 miles by 32 miles). This single-frequency SIR-C image was obtained by the L-band (24 cm) radar channel, horizontally transmitted and received. Portions of the Pacific Ocean visible in this image appear very dark as do freeways and other flat surfaces such as the airport runways. Mountains in the image are dark grey, with brighter patches on the mountain slopes, which face in the direction of the radar illumination (from the top of the image). Suburban areas, with the low-density housing and tree-lined streets that are typical of Los Angeles, appear as lighter grey. Areas with high-rise buildings, such as downtown Los Angeles, appear in very bright white, showing a higher density of housing and streets which run parallel to the radar flight track. Scientists hope to use radar image data from SIR-C/X-SAR to map fire scars in areas prone to brush fires, such as Los Angeles. In this image, the Altadena fire area is visible in the top center of the image as a patch of mountainous terrain which is slightly darker than the nearby mountains. Using all the radar frequency and polarization images provided by SIR

  7. Los plaguicidas y la contaminacion del medio ambiente Venezolano

    USGS Publications Warehouse

    Stickel, L.F.; Stickel, W.H.

    1972-01-01

    RESUMEN DE RECOMENDACIONES Recomendaciones para el Programa de Investigacion: 1. Establecer un sistema de muestreo biologico para detectar los niveles tendencias de los productos quimicos toxicos en un peque?o numero de si tios representativos. 2. Mantener continua vigilancia de la contaminacion ambiental, mediante la seleccion acertadamente dirigida de las zonas afectadas y de las fuentes de contaminacion. 3. Realizar estudios acerca de las poblaciones de animales silvestres, y del exito de los procesos reproductivos de las especies o grupos clayes de animales que se consideran mas gravemente afectados. 4. Preparar recomendaciones para una accion gubernamental de proteccion al hombre, a la fauna silvestre y al medio ambiente. Recomendaciones para la Accion Administrativa: 1. Establecer limites a la tolerancia de los residuos de plaguicidas en los alimentos. Constituye una medida clave para disminuir la contaminacion ambiental. 2. Establecer normas de calidad del agua para las corrientes, represas, la gos y otros cuerpos. Es la segunda medida clave para reducir la contaminacion del ambiente 3. Exigir un tratamiento adecuado de los efluentes industriales, especialmente antes de que se construyan las nuevas plantas. 4. Exigir a los agricultores que en el uso de plaguicidas sigan los consejos tecnicos autorizados y negar a los vendedores el derecho a recomendar productos por su cuenta. 5. Tomar medidas para recoger y eliminar los recipientes y sobrantes de los plaguicidas.

  8. Los Alamos National Laboratory computer benchmarking 1982

    SciTech Connect

    Martin, J.L.

    1983-06-01

    Evaluating the performance of computing machinery is a continual effort of the Computer Research and Applications Group of the Los Alamos National Laboratory. This report summarizes the results of the group's benchmarking activities performed between October 1981 and September 1982, presenting compilation and execution times as well as megaflop rates for a set of benchmark codes. Tests were performed on the following computers: Cray Research, Inc. (CRI) Cray-1S; Control Data Corporation (CDC) 7600, 6600, Cyber 73, Cyber 825, Cyber 835, Cyber 855, and Cyber 205; Digital Equipment Corporation (DEC) VAX 11/780 and VAX 11/782; and Apollo Computer, Inc., Apollo.

  9. Los Alamos National Laboratory strategic directions

    SciTech Connect

    Hecker, S.

    1995-10-01

    It is my pleasure to welcome you to Los Alamos. I like the idea of bringing together all aspects of the research community-defense, basic science, and industrial. It is particularly important in today`s times of constrained budgets and in fields such as neutron research because I am convinced that the best science and the best applications will come from their interplay. If we do the science well, then we will do good applications. Keeping our eye focused on interesting applications will spawn new areas of science. This interplay is especially critical, and it is good to have these communities represented here today.

  10. Environmental Programs at Los Alamos National Laboratory

    SciTech Connect

    Jones, Patricia

    2012-07-11

    Summary of this project is: (1) Teamwork, partnering to meet goals - (a) Building on cleanup successes, (b) Solving legacy waste problems, (c) Protecting the area's environment; (2) Strong performance over the past three years - (a) Credibility from four successful Recovery Act Projects, (b) Met all Consent Order milestones, (c) Successful ramp-up of TRU program; (3) Partnership between the National Nuclear Security Administration's Los Alamos Site Office, DOE Carlsbad Field Office, New Mexico Environment Department, and contractor staff enables unprecedented cleanup progress; (4) Continued focus on protecting water resources; and (5) All consent order commitments delivered on time or ahead of schedule.

  11. Astronomy Teaching in Argentina in the 19th Century. (Spanish Title: La Enseñanza de la Astronomía en la Argentina del Siglo XIX.) O Ensino de Astronomia na Argentina no Século XIX

    NASA Astrophysics Data System (ADS)

    Norberto Cornejo, Jorge; Santilli, Haydée

    2010-12-01

    Sarmiento believed that Copernican astronomy was one of the critical scientific disciplines to the formation of a "modern" citizen. In this work, we shall study astronomical science from two points of view: from the scientific knowledge and the educational presentation of such knowledge. Our study will address in Argentina in 19th century, starting from the initiative of Bernardino Rivadavia in 1821, who founded an astronomic observatory at Buenos Aires, until the first activities of the observatories at Córdoba and La Plata. On both lines, scientific and educative, we shall analyze the influence of positivist ideas. We shall highlight epistemological differences between both observatories, Córdoba's based on French positivism and La Plata's based on German positivism. We shall also show the different attitude of both observatories towards education. We shall see the way in which positivist ideas had great relevance in the training of elementary school teachers. We shall also establish the relevant influence of the socio-historical context over the astronomical development, and show that astronomy was a fundamental social factor at Argentina history. Domingo F. Sarmiento consideraba que la astronomía copernicana era una de las disciplinas científicas fundamentales para la conformación de un ciudadano "moderno". En este trabajo estudiaremos la ciencia astronómica desde dos vertientes: la referida específicamente al conocimiento científico y aquella vinculada con la presentación educativa de dicho conocimiento. Nuestro estudio se desarrollará en Argentina durante el siglo XIX, desde la iniciativa de Bernardino Rivadavia en 1821, de establecer en Buenos Aires un observatorio astronómico, hasta las primeras actividades de los observatorios de Córdoba y de La Plata. En ambas vertientes, científica y educativa, analizaremos la influencia de las ideas positivistas. Resaltaremos las diferencias epistemológicas entre los dos observatorios, orientado el primero

  12. Los Alamos National Laboratory Waste Management Program

    SciTech Connect

    Lopez-Escobedo, G.M.; Hargis, K.M.; Douglass, C.R.

    2007-07-01

    Los Alamos National Laboratory's (LANL) waste management program is responsible for disposition of waste generated by many of the LANL programs and operations. LANL generates liquid and solid waste that can include radioactive, hazardous, and other constituents. Where practical, LANL hazardous and mixed wastes are disposed through commercial vendors; low-level radioactive waste (LLW) and radioactive asbestos-contaminated waste are disposed on site at LANL's Area G disposal cells, transuranic (TRU) waste is disposed at the Waste Isolation Pilot Plant (WIPP), and high-activity mixed wastes are disposed at the Nevada Test Site (NTS) after treatment by commercial vendors. An on-site radioactive liquid waste treatment facility (RLWTF) removes the radioactive constituents from liquid wastes and treated water is released through an NPDES permitted outfall. LANL has a very successful waste minimization program. Routine hazardous waste generation has been reduced over 90% since 1993. LANL has a DOE Order 450.1-compliant environmental management system (EMS) that is ISO 14001 certified; waste minimization is integral to setting annual EMS improvement objectives. Looking forward, under the new LANL management and operating contractor, Los Alamos National Security (LANS) LLC, a Zero Liquid Discharge initiative is being planned that should eliminate flow to the RLWTF NPDES-permitted outfall. The new contractor is also taking action to reduce the number of permitted waste storage areas, to charge generating programs directly for the cost to disposition waste, and to simplify/streamline the waste system. (authors)

  13. Los Dias de Los Muertos. The Days of the Dead. 1991 Edition.

    ERIC Educational Resources Information Center

    Lane, Sarah; Turkovich, Marilyn

    The Dias de los Muertos is a celebration of Mexico that is a recognition of mortality, transience, and death, and a celebration of life, hope, and resurrection. This curriculum activity book begins with a general introduction to the festival followed by sections of explanations and activities intended to engage the learner in various aspects of…

  14. "Los Ninos y los Libros": Noteworthy Books in Spanish for the Very Young.

    ERIC Educational Resources Information Center

    Schon, Isabel

    2001-01-01

    Reviews 15 children's books in Spanish. Titles reviewed include: "Perro y gato [Dog and Cat]" (Ricardo Alcantara); "Baldomero va a la escuela [Baldomero goes to School]" (Alain Broutin); "Duerme bien, pequeno oso [Sleep well, Little Bear]" (Quint Buchholz); "El mas bonito de todos los regales del mundo [The Most Beautiful Gift in the World]…

  15. Biological assessment for the effluent reduction program, Los Alamos National Laboratory, Los Alamos, New Mexico

    SciTech Connect

    Cross, S.P.

    1996-08-01

    This report describes the biological assessment for the effluent recution program proposed to occur within the boundaries of Los Alamos National Laboratory. Potential effects on wetland plants and on threatened and endangered species are discussed, along with a detailed description of the individual outfalls resulting from the effluent reduction program.

  16. LAMPF II workshop, Los Alamos National Laboratory, Los Alamos, New Mexico, February 1-4, 1982

    SciTech Connect

    Thiessen, H.A.

    1982-01-01

    This report contains the proceedings of the first LAMPF II Workshop held at Los Alamos February 1 to 4, 1982. Included are the talks that were available in written form. The conclusion of the participants was that there are many exciting areas of physics that will be addressed by such a machine.

  17. Portable MRI developed at Los Alamos

    SciTech Connect

    Espy, Michelle

    2015-04-22

    Scientists at Los Alamos National Laboratory are developing an ultra-low-field Magnetic Resonance Imaging (MRI) system that could be low-power and lightweight enough for forward deployment on the battlefield and to field hospitals in the World's poorest regions. "MRI technology is a powerful medical diagnostic tool," said Michelle Espy, the Battlefield MRI (bMRI) project leader, "ideally suited for imaging soft-tissue injury, particularly to the brain." But hospital-based MRI devices are big and expensive, and require considerable infrastructure, such as large quantities of cryogens like liquid nitrogen and helium, and they typically use a large amount of energy. "Standard MRI machines just can't go everywhere," said Espy. "Soldiers wounded in battle usually have to be flown to a large hospital and people in emerging nations just don't have access to MRI at all. We've been in contact with doctors who routinely work in the Third World and report that MRI would be extremely valuable in treating pediatric encephalopathy, and other serious diseases in children." So the Los Alamos team started thinking about a way to make an MRI device that could be relatively easy to transport, set up, and use in an unconventional setting. Conventional MRI machines use very large magnetic fields that align the protons in water molecules to then create magnetic resonance signals, which are detected by the machine and turned into images. The large magnetic fields create exceptionally detailed images, but they are difficult and expensive to make. Espy and her team wanted to see if images of sufficient quality could be made with ultra-low-magnetic fields, similar in strength to the Earth's magnetic field. To achieve images at such low fields they use exquisitely sensitive detectors called Superconducting Quantum Interference Devices, or SQUIDs. SQUIDs are among the most sensitive magnetic field detectors available, so interference with the signal is the primary stumbling block. "SQUIDs are

  18. Portable MRI developed at Los Alamos

    ScienceCinema

    Espy, Michelle

    2016-07-12

    Scientists at Los Alamos National Laboratory are developing an ultra-low-field Magnetic Resonance Imaging (MRI) system that could be low-power and lightweight enough for forward deployment on the battlefield and to field hospitals in the World's poorest regions. "MRI technology is a powerful medical diagnostic tool," said Michelle Espy, the Battlefield MRI (bMRI) project leader, "ideally suited for imaging soft-tissue injury, particularly to the brain." But hospital-based MRI devices are big and expensive, and require considerable infrastructure, such as large quantities of cryogens like liquid nitrogen and helium, and they typically use a large amount of energy. "Standard MRI machines just can't go everywhere," said Espy. "Soldiers wounded in battle usually have to be flown to a large hospital and people in emerging nations just don't have access to MRI at all. We've been in contact with doctors who routinely work in the Third World and report that MRI would be extremely valuable in treating pediatric encephalopathy, and other serious diseases in children." So the Los Alamos team started thinking about a way to make an MRI device that could be relatively easy to transport, set up, and use in an unconventional setting. Conventional MRI machines use very large magnetic fields that align the protons in water molecules to then create magnetic resonance signals, which are detected by the machine and turned into images. The large magnetic fields create exceptionally detailed images, but they are difficult and expensive to make. Espy and her team wanted to see if images of sufficient quality could be made with ultra-low-magnetic fields, similar in strength to the Earth's magnetic field. To achieve images at such low fields they use exquisitely sensitive detectors called Superconducting Quantum Interference Devices, or SQUIDs. SQUIDs are among the most sensitive magnetic field detectors available, so interference with the signal is the primary stumbling block. "SQUIDs are

  19. Comprension de los conceptos de los enlaces ionico y covalente en estudiantes universitarios del primer curso de quimica general

    NASA Astrophysics Data System (ADS)

    Ballesteros Benavides, Maria Elvira

    Para este trabajo utilizamos el estudio de casos cualitativo que se llevo a cabo en una universidad privada de Puerto Rico. Empleamos como unidad de analisis el concepto de enlace quimico, ionico y covalente. Los participantes fueron los estudiantes de la seccion nocturna del curso de Quimica General I. La investigacion se desarrollo por medio de dos entrevistas de persona a persona, observaciones de las expresiones no verbales y la hoja de identificacion de conceptos. Para la triangulacion tomamos en consideracion las preconcepciones erroneas, las concepciones alternativas y el mapa de conceptos de cada participante. Preparamos un mapa de conceptos para el enlace quimico validado por un comite de expertos. Tambien, elaboramos los mapas de conceptos de los participantes que sirvieron para varios propositos: conocer la estructura conceptual, expresar los logros, hacer comparaciones e identificar la presencia de concepciones alternativas. Entre los hallazgos encontramos que todos los participantes poseen conocimiento previo de los enlaces quimicos ionico y covalente y dentro de ese conocimiento existen preconcepciones erroneas mas numerosas para el enlace ionico. Al principio del semestre el 50% de los participantes demostraron tener "carencia fuerte de conceptos" tanto para el enlace ionico como para el covalente. Al finalizar el semestre encontramos en el 40% de los participantes concepciones alternativas tanto para el enlace ionico como para el covalente y el 90% no lograron distinguir un enlace del otro. Nuestras conclusiones fueron que los participantes sin distincion del aprovechamiento academico demostraron tener la tendencia de "carencia fuerte de conceptos" tanto para el enlace ionico como para el covalente, presentaron dificultad al integrar los conceptos de los enlaces quimicos ionico y covalente que se pusieron de manifiesto al dar los ejemplos. Las preconcepciones erroneas contribuyen en el desarrollo de las concepciones alternativas. Ademas, los

  20. Los Alamos National Laboratory transuranic database analysis

    SciTech Connect

    Christensen, D.V.; Rogers, P.S.Z.; Kosiewicz, S.T.; LeBrun, D.B.

    1997-02-01

    This paper represents an overview of analyses conducted on the TRU database maintained by the Los Alamos National Laboratory (LANL). This evaluation was conducted to support the ``TRU Waste Workoff Strategies`` document and provides an estimation of the waste volume that potentially could be certified and ready for shipment to (WIPP) in April of 1998. Criteria defined in the WIPP WAC, including container type, weight limits, plutonium fissile gram equivalents and decay heat, were used to evaluated the waste for compliance. LANL evaluated the containers by facility and by waste stream to determining the most efficient plan for characterization and certification of the waste. Evaluation of the waste presently in storage suggested that 40- 60% potentially meets the WIPP WAC Rev. 5 criteria.

  1. Los Alamos Advanced Free-Electron Laser

    SciTech Connect

    Chan, K.C.D.; Kraus, R.H.; Ledford, J.; Meier, K.L.; Meyer, R.E.; Nguyen, D.; Sheffield, R.L.; Sigler, F.L.; Young, L.M.; Wang, T.S.; Wilson, W.L.; Wood, R.L.

    1991-01-01

    At Los Alamos, we are building a free-electron laser (FEL) for industrial, medical, and research applications. This FEL, which will incorporate many of the new technologies developed over the last decade, will be compact in size, robust, and user-friendly. Electrons produced by a photocathode will be accelerated to 20 MeV by a high-brightness accelerator and transported using permanent-magnet quadrupoles and dipoles. They will form an electron beam with an excellent instantaneous beam quality of 10 {pi} mm mrad in transverse emittance and 0.3% in energy spread at a peak current up to 300 A. Including operation at higher harmonics, the laser wavelength extends form 3.7 {mu}m to 0.4 {mu}m. In this paper, we will describe the project and the programs to date. 10 refs., 10 figs., 1 tab.

  2. Environmental surveillance at Los Alamos during 1979

    SciTech Connect

    Not Available

    1980-04-01

    This report documents the environmental surveillance program conducted by the Los Alamos Scientific Laboratory (LASL) in 1979. Routine monitoring for radiation and radioactive or chemical substances was conducted on the Laboratory site and in the surrounding region to determine compliance with appropriate standards and permit early identification of possible undesirable trends. Results and interpretation of the data for 1979 on penetrating radiation, chemical and radiochemical quality of ambient air, surface and ground water, municipal water supply, soils and sediments, food, and airborne and liquid effluents are included. Comparisons with appropriate standards and regulations or with background levels from natural or other non-LASL sources provide a basis for concluding that environmental effects attributable to LASL operations are minor and cannot be considered likely to result in any hazard to the population of the area. Results of several special studies provide documentation of some unique environmental conditions in the LASL environs.

  3. Environmental surveillance at Los Alamos during 1987

    SciTech Connect

    Not Available

    1988-05-01

    This report describes the environmental surveillance program conducted by Los Alamos National Laboratory during 1987. Routine monitoring for radiation and radioactive or chemical materials is conducted on the Laboratory site as well as in the surrounding region. Monitoring results are used to determine compliance with appropriate standards and to permit early identification of potentially undesirable trends. Results and interpretation of data for 1987 cover: external penetrating radiation; quantities of airborne emissions and liquid effluents; concentrations of chemicals and radionuclides in ambient air, surface and ground waters, municipal water supply, soils and sediments, and foodstuffs; and environmental compliance. Comparisons with appropriate standards, regulations, and background levels provide the basis for concluding that environmental effects from Laboratory operations are insignificant and do not pose a threat to the public, Laboratory employees, or the environment. 113 refs., 33 figs., 120 tabs.

  4. Environmental surveillance at Los Alamos during 1989

    SciTech Connect

    Not Available

    1990-12-01

    This report describes the environmental surveillance program conducted by Los Alamos National Laboratory during 1989. Routine monitoring for radiation and radioactive or chemical materials is conducted on the Laboratory site as well as in the surrounding region. Monitoring results are used to determine compliance with appropriate standards and to permit early identification of potentially undesirable trends. Results and interpretation of data for 1989 cover external penetrating radiation; quantities of airborne emissions and effluents; concentrations of chemicals and radionuclides in ambient air, surface and ground waters, municipal water supply, soils and sediments, and foodstuffs; and environmental compliance. Comparisons with appropriate standards, regulations, and background levels provide the basis for concluding that environmental effects from Laboratory operations are small and do not pose a threat to the public, Laboratory employees, or the environment. 58 refs., 31 figs., 39 tabs.

  5. Information about Practicums at Los Alamos

    SciTech Connect

    Bradley, Paul A.

    2012-07-24

    The Los Alamos Neutron Science Center is the premier facility for neutron science experiments ranging from cross section measurements, neutron scattering experiments, proton radiography, cold neutrons, actinide neutronic properties, and many other exciting topics. The National High Magnetic Field Laboratory is home to several powerful magnets, including the one that created the first non-destructive 100 Tesla field in March 2012. They probe the electronic structure of superconductors, magnetic properties of materials (including magneto-quantum effects). Research is also conducted in correlated materials, thermoacoustics, and magnetic properties of actinides. The Trident Laser has a unique niche with very high power, short pulse experiments, with a peak power of 10{sup 20} W in short pulse mode. Discoveries range from production of monoenergetic MeV ion beam, nonlinear kinetic plasma waves, the transition between kinetic and fluid nonlinear behavior and other laser-plasma interaction processes.

  6. Environmental surveillance at Los Alamos during 1995

    SciTech Connect

    1996-10-01

    This report describes the environmental surveillance program at Los Alamos National Laboratory (LANL or the Laboratory) during 1995. The Laboratory routinely monitors for radiation and for radioactive and nonradioactive materials at (or on) Laboratory sites as well as in the surrounding region. LANL uses the monitoring result to determine compliance with appropriate standards and to identify potentially undesirable trends. Data were collected in 1995 to assess external penetrating radiation; quantities of airborne emissions and liquid effluents; concentrations of chemicals and radionuclides in ambient air, surface waters and groundwaters, municipal water supply, soils and sediments, and foodstuffs; and environmental compliance. Using comparisons with standards, regulations, and background levels, this report concludes that environmental effects from Laboratory operations are small and do not pose a demonstrable threat to the public, Laboratory employees, or the environment.

  7. Environmental surveillance at Los Alamos during 1992

    SciTech Connect

    Kohen, K.; Stoker, A.; Stone, G.

    1994-07-01

    This report describes the environmental surveillance program at Los Alamos National Laboratory during 1992. The Laboratory routinely monitors for radiation and for radioactive and nonradioactive materials at (or on) Laboratory sites as well as in the surrounding region. LANL uses the monitoring results to determine compliance with appropriate standards and to identify potentially undesirable trends. Data were collected in 1992 to assess external penetrating radiation; quantities of airborne emissions and liquid effluents; concentrations of chemicals and radionuclides in ambient air, surface waters and groundwaters, municipal water supply, soils and sediments, and foodstuffs; and environmental compliance. Using comparisons with standards, regulations, and background levels, this report concludes that environmental effects from Laboratory operations are small and do not pose a demonstrable threat to the public, laboratory employees, or the environment.

  8. Hot Dry Rock Overview at Los Alamos

    SciTech Connect

    Berger, Michael; Hendron, Robert H.

    1989-03-21

    The Hot Dry Rock (HDR) geothermal energy program is a renewable energy program that can contribute significantly to the nation's balanced and diversified energy mix. Having extracted energy from the first Fenton Hill HDR reservoir for about 400 days, and from the second reservoir for 30 days in a preliminary test, Los Alamos is focusing on the Long Term Flow Test and reservoir studies. Current budget limitations have slowed preparations thus delaying the start date of that test. The test is planned to gather data for more definitive reservoir modeling with energy availability or reservoir lifetime of primary interest. Other salient information will address geochemistry and tracer studies, microseismic response, water requirements and flow impedance which relates directly to pumping power requirements. During this year of ''preparation'' we have made progress in modeling studies, in chemically reactive tracer techniques, in improvements in acoustic or microseismic event analysis.

  9. Environmental surveillance at Los Alamos during 2008

    SciTech Connect

    Fuehne, David; Gallagher, Pat; Hjeresen, Denny; Isaacson, John; Johson, Scot; Morgan, Terry; Paulson, David; Rogers, David

    2009-09-30

    Environmental Surveillance at Los Alamos reports are prepared annually by the Los Alamos National Laboratory (the Laboratory) Environmental Programs Directorate, as required by US Department of Energy Order 450.1, General Environmental Protection Program, and US Department of Energy Order 231.1A, Environment, Safety, and Health Reporting. These annual reports summarize environmental data that are used to determine compliance with applicable federal, state, and local environmental laws and regulations, executive orders, and departmental policies. Additional data, beyond the minimum required, are also gathered and reported as part of the Laboratory’s efforts to ensure public safety and to monitor environmental quality at and near the Laboratory. Chapter 1 provides an overview of the Laboratory’s major environmental programs and explains the risks and the actions taken to reduce risks at the Laboratory from environmental legacies and waste management operations. Chapter 2 reports the Laboratory’s compliance status for 2007. Chapter 3 provides a summary of the maximum radiological dose the public and biota populations could have potentially received from Laboratory operations and discusses chemical exposures. The environmental surveillance and monitoring data are organized by environmental media (Chapter 4, air; Chapters 5 and 6, water and sediments; Chapter 7, soils; and Chapter 8, foodstuffs and biota) in a format to meet the needs of a general and scientific audience. Chapter 9 provides a summary of the status of environmental restoration work around LANL. A glossary and a list of acronyms and abbreviations are in the back of the report. Appendix A explains the standards for environmental contaminants, Appendix B explains the units of measurements used in this report, Appendix C describes the Laboratory’s technical areas and their associated programs, and Appendix D provides web links to more information.

  10. Environmental surveillance at Los Alamos during 2009

    SciTech Connect

    Fuehne, David; Poff, Ben; Hjeresen, Denny; Isaacson, John; Johnson, Scot; Morgan, Terry; Paulson, David; Salzman, Sonja; Rogers, David

    2010-09-30

    Environmental Surveillance at Los Alamos reports are prepared annually by the Los Alamos National Laboratory (the Laboratory) environmental organization, as required by US Department of Energy Order 5400.1, General Environmental Protection Program, and US Department of Energy Order 231.1A, Environment, Safety, and Health Reporting. These annual reports summarize environmental data that are used to determine compliance with applicable federal, state, and local environmental laws and regulations, executive orders, and departmental policies. Additional data, beyond the minimum required, are also gathered and reported as part of the Laboratory’s efforts to ensure public safety and to monitor environmental quality at and near the Laboratory. Chapter 1 provides an overview of the Laboratory’s major environmental programs and explains the risks and the actions taken to reduce risks at the Laboratory from environmental legacies and waste management operations. Chapter 2 reports the Laboratory’s compliance status for 2009. Chapter 3 provides a summary of the maximum radiological dose the public and biota populations could have potentially received from Laboratory operations and discusses chemical exposures. The environmental surveillance and monitoring data are organized by environmental media (air in Chapter 4; water and sediments in Chapters 5 and 6; soils in Chapter 7; and foodstuffs and biota in Chapter 8) in a format to meet the needs of a general and scientific audience. Chapter 9 provides a summary of the status of environmental restoration work around LANL. The new Chapter 10 describes the Laboratory’s environmental stewardship efforts and provides an overview of the health of the Rio Grande. A glossary and a list of acronyms and abbreviations are in the back of the report. Appendix A explains the standards for environmental contaminants, Appendix B explains the units of measurements used in this report, Appendix C describes the Laboratory’s technical

  11. Environmental surveillance at Los Alamos during 2005

    SciTech Connect

    2006-09-30

    Environmental Surveillance at Los Alamos reports are prepared annually by the Los Alamos National Laboratory (LANL or the Laboratory) environmental organization, as required by US Department of Energy Order 5400.1, General Environmental Protection Program, and US Department of Energy Order 231.IA, Environment, Safety, and Health Reporting. These annual reports summarize environmental data that are used to determine compliance with applicable federal, state, and local environmental laws and regulations, executive orders, and departmental policies. Additional data, beyond the minimum required, are also gathered and reported as part of the Laboratory's efforts to ensure public safety and to monitor environmental quality at and near the Laboratory. Chapter 1 provides an overview of the Laboratory's major environmental programs. Chapter 2 reports the Laboratory's compliance status for 2005. Chapter 3 provides a summary of the maximum radiological dose the public and biota populations could have potentially received from Laboratory operations. The environmental surveillance and monitoring data are organized by environmental media (Chapter 4, Air; Chapters 5 and 6, Water and Sediments; Chapter 7, Soils; and Chapter 8, Foodstuffs and Biota) in a format to meet the needs of a general and scientific audience. Chapter 9, new for this year, provides a summary of the status of environmental restoration work around LANL. A glossary and a list ofacronyms and abbreviations are in the back of the report. Appendix A explains the standards for environmental contaminants, Appendix B explains the units of measurements used in this report, Appendix C describes the Laboratory's technical areas and their associated programs, and Appendix D provides web links to more information.

  12. Meningococcal group A lipooligosaccharides (LOS): preliminary structural studies and characterization of serotype-associated and conserved LOS epitopes.

    PubMed Central

    Kim, J J; Phillips, N J; Gibson, B W; Griffiss, J M; Yamasaki, R

    1994-01-01

    Structural studies indicate that the neisserial lipooligosaccharides (LOS) are composed of an oligosaccharide (OS) portion with a phosphorylated diheptose (Hep) core attached to the toxic lipid A moiety. A conserved meningococcal LOS epitope, defined by monoclonal antibody (MAb) D6A, is expressed on group A and many group B and C meningococci of different LOS serotypes (J. J. Kim, R. E. Mandrell, H. Zhen, M. A. Apicella, J. T. Poolman, and J. M. Griffiss, Infect. Immun. 56:2631-2638, 1988). This MAb-defined D6A epitope is immunogenic in humans (M. M. Estabrook, R. E. Mandrell, M. A. Apicella, and J. M. Griffiss, Infect. Immun. 58:2204-2213, 1990; M. M. Estabrook, C. J. Baker, and J. M. Griffiss, J. Infect. Dis. 197:966-970, 1993). In this study, we characterize this important MAb-defined LOS epitope. Serotype L10 and L11 group A meningococal LOS were chemically modified and used to investigate what portion of the LOS molecule is important for expression of the conserved (D6A) epitope and serotype-associated LOS epitopes by use of immunoblotting techniques and selected MAbs as probes. Preliminary structural characterization of the LOS was also accomplished by electrospray ionization-mass spectrometry. Our results indicate the following. (i) Antibodies that recognize the serotype-associated or conserved LOS epitopes recognize the OS portion of the LOS. (ii) The phosphorylated diheptose core region of the OS is essential for expression of the conserved D6A epitope. (iii) The lipid portion of the molecule is important for optimum expression of the LOS epitopes. (iv) The proposed compositions of the O-deacylated LOS are consistent with the presence of a phosphorylated diheptose core and are as follows: for O-deacylated L10 LOS, 3Hex (hexose), 1HexNAc (N-acetylhexosamine), 2KDO (2-keto-3-deoxy-D-manno-octulosonic acid), 2Hep (heptose), 1PEA or 2PEA (phosphoethanolamine), and O-deacylated lipid A; and for O-deacylated L11 LOS, 2Hex, 1HexNAc, 2KDO, 2Hep, 2PEA, and O

  13. El problema de estabilidad de los sistemas Hamiltonianos multidimensionales

    NASA Astrophysics Data System (ADS)

    Cincotta, P. M.

    Se revisarán los aspectos básicos del problema de estabilidad de sistemans Hamiltonianos N-dimensionales, haciendo especial énfasis en los posibles mecanismos que dan lugar a la aparición de ``caos": overlap de resonancias, difusión de Arnol'd y otros procesos difusivos alternativos. Se mencionarán los aspectos aún no resueltos sobre la estabilidad de los sistemas con N > 2. Finalmente, se discutirá cuáles de estos mecanismos podrían tener alguna relevancia en la dinámica de sistemas estelares y planetarios.

  14. The LACDA (Los Angeles County Drainage Area) System Recreation Study, Los Angeles County Drainage Area.

    DTIC Science & Technology

    1980-03-01

    the Nation dt, t:... .. .Los Angeles District in association with DANIEL, MANN, JOHNSON, & MENDENHALL URBAN DESIGN DISCIPLINES, INC. 3250 WILSHIRE...POTENTIAL TRAIL PROJECTS 4-3 Planning and Design of Trail Projects 4-3 Classification of Potential Trail Projects 4-3 Bicycle Trails 4-6 Equestrian...bicycles for both recreation routes and the design of trail facilities: arid commuting and would be a major stimulus to equestrian activity in the area

  15. Environmental analysis of Lower Pueblo/Lower Los Alamos Canyon, Los Alamos, New Mexico

    SciTech Connect

    Ferenbaugh, R.W.; Buhl, T.E.; Stoker, A.K.; Becker, N.M.; Rodgers, J.C.; Hansen, W.R.

    1994-12-01

    The radiological survey of the former radioactive waste treatment plant site (TA-45), Acid Canyon, Pueblo Canyon, and Los Alamos Canyon found residual contamination at the site itself and in the channel and banks of Acid, Pueblo, and lower Los Alamos Canyons all the way to the Rio Grande. The largest reservoir of residual radioactivity is in lower Pueblo Canyon, which is on DOE property. However, residual radioactivity does not exceed proposed cleanup criteria in either lower Pueblo or lower Los Alamos Canyons. The three alternatives proposed are (1) to take no action, (2) to construct a sediment trap in lower Pueblo Canyon to prevent further transport of residual radioactivity onto San Ildefonso Indian Pueblo land, and (3) to clean the residual radioactivity from the canyon system. Alternative 2, to cleanup the canyon system, is rejected as a viable alternative. Thousands of truckloads of sediment would have to be removed and disposed of, and this effort is unwarranted by the low levels of contamination present. Residual radioactivity levels, under either present conditions or projected future conditions, will not result in significant radiation doses to persons exposed. Modeling efforts show that future transport activity will not result in any residual radioactivity concentrations higher than those already existing. Thus, although construction of a sediment trap in lower Pueblo Canyon is a viable alternative, this effort also is unwarranted, and the no-action alternative is the preferred alternative.

  16. Studies of the Los Angeles aerosol:

    NASA Astrophysics Data System (ADS)

    Xiong, Cheng

    This work addresses two important but little studied aspects of the behavior of the atmospheric aerosol: (1)the contributions of the atmospheric aerosol to the surface microlayer (SMIC) of natural waters (a biochemically sensitive site) and (2)the morphological properties of atmospheric aerosols. The first part of the study involved a cooperative program for concurrent measurements of atmospheric aerosol, SMIC, and water column samples. Our group measured aerosol chemical characteristics (in terms of total concentrations and size distributions of various elements) at several locations on the west side of Los Angeles including above Santa Monica Bay. Scatter diagrams were made of SMIC concentrations for various elements vs. atmospheric aerosol concentrations of the same elements for similar time periods. The scatter diagrams identified a subset of elements in the SMIC that tended to increase with the atmospheric concentrations of the same elements. For these elements atmospheric deposition is probably a major source in the SMIC. Our scatter diagrams offer a novel approach to source resolution for the SMIC and potentially, a new method of determining dry deposition rates to natural waters. The second part of the research describes the first systematic study of the morphological properties of atmospheric aggregates in the ultrafine particle size range (dp <= 0.1 μm). These aggregates are emitted from diesel engines and other high temperature sources and have been linked to adverse effects on public health. Particles were collected from the atmospheric air on transmission electron microscope (TEM) grids fitted on the last two stages of a single- jet, eight-stage, low pressure impactor (LPI). Photomicrographs of the TEM grids were analyzed to obtain the fractal dimension (D f) and prefactor (A) for aggregates. Values of Df increased from near 1 to above 2 as the number of primary particles making up the aggregates increased from 10 to 180 for the measurements made in

  17. Environmental Surveillance at Los Alamos during 2007

    SciTech Connect

    2008-09-30

    Environmental Surveillance at Los Alamos reports are prepared annually by the Los Alamos National Laboratory (the Laboratory) Environmental Directorate, as required by US Department of Energy Order 450.1, General Environmental Protection Program, and US Department of Energy Order 231.1A, Environment, Safety, and Health Reporting. These annual reports summarize environmental data that are used to determine compliance with applicable federal, state, and local environmental laws and regulations, executive orders, and departmental policies. Additional data, beyond the minimum required, are also gathered and reported as part of the Laboratory’s efforts to ensure public safety and to monitor environmental quality at and near the Laboratory. Chapter 1 provides an overview of the Laboratory’s major environmental programs and explains the risks and the actions taken to reduce risks at the Laboratory from environmental legacies and waste management operations. Chapter 2 reports the Laboratory’s compliance status for 2007. Chapter 3 provides a summary of the maximum radiological dose the public and biota populations could have potentially received from Laboratory operations and discusses chemical exposures. The environmental surveillance and monitoring data are organized by environmental media (Chapter 4, air; Chapters 5 and 6, water and sediments; Chapter 7, soils; and Chapter 8, foodstuffs and biota) in a format to meet the needs of a general and scientific audience. Chapter 9 provides a summary of the status of environmental restoration work around LANL. A glossary and a list of acronyms and abbreviations are in the back of the report. Appendix A explains the standards for environmental contaminants, Appendix B explains the units of measurements used in this report, Appendix C describes the laboratory’s technical areas and their associated programs, and Appendix D provides web links to more information. In printed copies of this report or Executive Summary, we have

  18. Preparación de los adultos mayores en los Estados Unidos para hacer frente a los desastres naturales: encuesta a escala nacional*

    PubMed Central

    Al-rousan, Tala M.; Rubenstein, Linda M.; Wallace, Robert B.

    2015-01-01

    Objetivos. Nos propusimos determinar el grado de preparación frente a los desastres naturales de los adultos mayores en los Estados Unidos y evaluar los factores que pueden afectar negativamente la salud y la seguridad durante este tipo de incidentes. Métodos. Obtuvimos una muestra de adultos de 50 años en adelante (n = 1 304) de la encuesta del 2010 del Estudio de la Salud y la Jubilación (HRS por su sigla en inglés). La encuesta recogió datos sobre las características demográficas generales, el estado de discapacidad o las limitaciones funcionales, y también sobre factores y comportamientos relacionados con la preparación frente a los desastres. Calculamos una puntuación global de preparación mediante indicadores individuales a fin de evaluar el grado de preparación general. Resultados. La media de la edad de los participantes (n = 1 304) fue de 70 años (desviación estándar [DE] = 9,3). Solo 34,3% informaron que habían participado en un programa formativo o que habían leído materiales sobre la preparación para los desastres. Casi 15% indicaron que usaban dispositivos médicos eléctricos que podían correr riesgo de no funcionar si se interrumpiera el suministro eléctrico. La puntuación de preparación indicó que la edad más avanzada, la discapacidad física y el menor nivel de escolaridad y de ingresos se asociaban independiente y significativamente a un grado de preparación general inferior. Conclusiones. A pesar de la mayor vulnerabilidad ante los desastres y del número cada vez mayor de adultos mayores en los Estados Unidos, muchos de los problemas sustanciales que encontramos son remediables y requieren atención en los sectores de la sociedad dedicados a la atención clínica, a la salud pública y al manejo de situaciones de emergencia.

  19. Envisioning a Public Research Agenda in Los Angeles

    ERIC Educational Resources Information Center

    Vogelgesang, Lori J.; Gilliam, Franklin D., Jr.; O'Byrne, Kathy; Leal-Sotelo, Margaret

    2006-01-01

    The University of California, Los Angeles is an institution founded on a public mission and positioned as a world-renowned research university. This article describes the successes, challenges and future directions of a concerted institutional effort to engage with the broader Los Angeles community to address pressing social issues and needs. The…

  20. Dialect Contact among Spanish-Speaking Children in Los Angeles

    ERIC Educational Resources Information Center

    Villarreal, Belen MacGregor

    2014-01-01

    As an immigration hub for a diverse group of Spanish speakers, Los Angeles lends itself to research on dialect contact and leveling. Studies regarding the Spanish spoken by natives of Los Angeles reveal considerable homogeneity with respect to pronunciation, vocabulary and terms of address. This uniformity is notable because two different dialect…

  1. Los Alamos personnel and area criticality dosimeter systems

    SciTech Connect

    Vasilik, D.G.; Martin, R.W.

    1981-06-01

    Fissionable materials are handled and processed at the Los Alamos National Laboratory. Although the probability of a nuclear criticality accident is very remote, it must be considered. Los Alamos maintains a broad spectrum of dose assessment capabilities. This report describes the methods employed for personnel neutron, area neutron, and photon dose evaluations with passive dosimetry systems.

  2. The Climate at Los Alamos; Are we measurement changes?

    SciTech Connect

    Dewart, Jean Marie

    2015-04-16

    A new report shows new graphic displays of the weather trends in Los Alamos, New Mexico, and at the Los Alamos National Laboratory (LANL). The graphs show trends of average, minimum average, and maximum average temperature for summer and winter months going back decades. Records of summer and winter precipitation are also included in the report.

  3. Audit of personal property management at Los Alamos National Laboratory

    SciTech Connect

    Not Available

    1993-12-07

    The Department of Energy`s (Department) Albuquerque Operations Office (Albuquerque) and the Los Alamos National Laboratory (Los Alamos) are responsible for ensuring that Los Alamos maintains an efficient and effective personal property management system that protects, identifies, and controls Government-owned personal property in accordance with applicable regulations. Albuquerque is responsible for reviewing and approving Los Alamos` personal property management system. Los Alamos is responsible for ensuring that personal property is properly protected, identified, and controlled. The audit disclosed that Los Alamos did not have an efficient and effective personal property management system to ensure that personal property was adequately protected, identified, and controlled. In addition, Albuquerque did not approve or disapprove Los Alamos` personal property management system consistent with Federal and Department regulations. Specifically, the audit showed that Los Alamos did not account for $11.6 million of personal property. In addition, $22.2 million of personal property was not properly recorded in the database, $61.7 million of personal property could not be inventoried, and loans to employees and other entities were not adequately justified. As a result, from a total personal property inventory of approximately $1 billion, it is estimated that $100 million of personal property may not be accounted for, and $207 million may not be correctly recorded in the database. Moreover, substantial amounts of personal property on loan to employees and other entities were at risk of unauthorized use. Albuquerque concurred with the finding and agreed to implement the corrective actions recommended in the report.

  4. Coca-Cola Hispanic Education Fund: Los Angeles Program Description.

    ERIC Educational Resources Information Center

    Coca Cola Bottling Co. of Los Angeles, CA.

    The Coca-Cola Hispanic Education Fund was created in response to the high school dropout problem in Los Angeles. The Fund enables the Coca-Cola Bottling Company of Los Angeles to build upon the successful relationship it has developed in the Hispanic community and maximizes the effectiveness of existing student support programs by directing needy…

  5. Los LGBT y fumar | Smokefree Español

    Cancer.gov

    En Estados Unidos, las personas lesbianas, gays, bisexuales y transexuales (LGBT) tienen el doble de probabilidades de empezar a fumar que los heterosexuales. Sepa por qué los miembros de la comunidad LGBT fuman y aprenda estrategias para dejar de fumar definitivamente.

  6. Glitches in Los Angeles Payroll System Spark Furor

    ERIC Educational Resources Information Center

    Trotter, Andrew

    2007-01-01

    Thousands of Los Angeles teachers have not been paid properly for months because of errors in a corporate-style payroll system that was introduced in January as part of a sweeping, $95 million computer modernization. The Los Angeles Unified School District acknowledges that the payroll system's rollout was rushed and tainted by numerous…

  7. Korean Language Maintenance in Los Angeles. Professional Papers K-1.

    ERIC Educational Resources Information Center

    Kim, Kenneth Kong-On; And Others

    Characteristics of the Korean population in Los Angeles, intergenerational cultural problems, and efforts to promote language maintenance are described. The majority of Koreans in Los Angeles have been in the United States less than 10 years. A high percentage are from middle class and professional backgrounds. The traditional hierarchical family…

  8. Los Angeles Tries Luring Back Dropouts via Social Networks

    ERIC Educational Resources Information Center

    Maxwell, Lesli A.

    2007-01-01

    This article reports that education leaders in Los Angeles, faced with unrelenting pressure to raise anemic high school graduation rates, are turning to YouTube, MySpace, text messaging, and the radio waves to reach students at risk of dropping out of school and lure back thousands who have already left. The Los Angeles Unified School…

  9. Battle in Los Angeles: Conflict Escalates as Charter Schools Thrive

    ERIC Educational Resources Information Center

    Whitmire, Richard

    2016-01-01

    Throughout the 1990s and well into the new millennium, the massive Los Angeles Unified School District barely noticed the many charter schools that were springing up around the metropolis. But Los Angeles parents certainly took notice, and started enrolling their children. In 2008, five charter-management organizations announced plans to…

  10. Los Alamos upgrade in metallographic capabilities

    SciTech Connect

    Ledbetter, J.M.; Dowler, K.E.; Cook, J.H.

    1985-01-01

    The Los Alamos Wing 9 Hot Cell Facility is in the process of upgrading their metallographic sample preparation and examination capability. The present capability to grind, polish and etch samples from reactor fuels and materials has been in operation for 18 years. Macro photography and alpha and beta-gamma autoradiography are an important part of this capability. Some of the fast breeder reactor experiments have contained sodium as a coolant. Therefore, the capability to distill sodium from some samples scheduled for microstructural examinations is a requirement. Since the reactor fuel samples are highly radioactive and contain plutonium, either as fabricated or as a result of breeding during reactor service, these samples must be handled in shielded hot cells containing alpha boxes to isolate the plutonium and hazardous fission products from personnel and the environment. The present equipment that was designed and built into those alpha boxes has functioned very well for the past 18 years. During that time the technicians have thought of ways to improve the equipment to do the work faster and safer. These ideas and ideas that have been developed during the design of new alpha boxes and new equipment for microstructural sample preparation have provided the concepts for the capability to perform the work faster and maintain the equipment in a safer manner.

  11. Saving Water at Los Alamos National Laboratory

    ScienceCinema

    Erickson, Andy

    2016-07-12

    Los Alamos National Laboratory decreased its water usage by 26 percent in 2014, with about one-third of the reduction attributable to using reclaimed water to cool a supercomputing center. The Laboratory's goal during 2014 was to use only re-purposed water to support the mission at the Strategic Computing Complex. Using reclaimed water from the Sanitary Effluent Reclamation Facility, or SERF, substantially decreased water usage and supported the overall mission. SERF collects industrial wastewater and treats it for reuse. The reclamation facility contributed more than 27 million gallons of re-purposed water to the Laboratory's computing center, a secured supercomputing facility that supports the Laboratory’s national security mission and is one of the institution’s larger water users. In addition to the strategic water reuse program at SERF, the Laboratory reduced water use in 2014 by focusing conservation efforts on areas that use the most water, upgrading to water-conserving fixtures, and repairing leaks identified in a biennial survey.

  12. Historic Manhattan Project Sites at Los Alamos

    ScienceCinema

    McGehee, Ellen

    2016-07-12

    The Manhattan Project laboratory constructed at Los Alamos, New Mexico, beginning in 1943, was intended from the start to be temporary and to go up with amazing speed. Because most of those WWII-era facilities were built with minimal materials and so quickly, much of the original infrastructure was torn down in the late '40s and early '50s and replaced by more permanent facilities. However, a few key facilities remained, and are being preserved and maintained for historic significance. Four such sites are visited briefly in this video, taking viewers to V-Site, the buildings where the first nuclear explosive device was pre-assembled in preparation for the Trinity Test in Southern New Mexico. Included is another WWII area, Gun Site. So named because it was the area where scientists and engineers tested the so-called "gun method" of assembling nuclear materials -- the fundamental design of the Little Boy weapon that was eventually dropped on Hiroshima. The video also goes to Pajarito Site, home of the "Slotin Building" and "Pond Cabin." The Slotin Building is the place where scientist Louis Slotin conducted a criticality experiment that went awry in early 1946, leading to his unfortunate death, and the Pond Cabin served the team of eminent scientist Emilio Segre who did early chemistry work on plutonium that ultimately led to the Fat Man weapon.

  13. Epidemiology of pancreas cancer in Los Angeles

    SciTech Connect

    Mack, T.M.; Paganini-Hill, A.

    1981-03-15

    The characteristics of the 3614 Los Angeles County residents in whom cancer of the exocrine pancreas was diagnosed during the period 1972-1977 were compared with those of all county residents and patients in whom any cancer was diagnosed during the same period. Seventy-nine percent of the diagnoses had been pathologically verified. This disease still preferentially afflicts the old, the black, and men, although the differences in risk with factors other than age are modest. The disease is not evenly distributed by social class, or over time, although it is not clear that the observed differences reflect etiology. The distributions with respect to important categories of occupation and industry, religion, marital status, geography of residence, and birthplace were rather uniform. Although there is no obvious explanation for any of several unexpected minor inequities in the pattern of incidence, there is no compelling evidence to support any specific environmental cause. There is substantial evidence which is inconsistent with those environmental hypotheses that have been proposed previously.

  14. Historic Manhattan Project Sites at Los Alamos

    SciTech Connect

    McGehee, Ellen

    2014-05-22

    The Manhattan Project laboratory constructed at Los Alamos, New Mexico, beginning in 1943, was intended from the start to be temporary and to go up with amazing speed. Because most of those WWII-era facilities were built with minimal materials and so quickly, much of the original infrastructure was torn down in the late '40s and early '50s and replaced by more permanent facilities. However, a few key facilities remained, and are being preserved and maintained for historic significance. Four such sites are visited briefly in this video, taking viewers to V-Site, the buildings where the first nuclear explosive device was pre-assembled in preparation for the Trinity Test in Southern New Mexico. Included is another WWII area, Gun Site. So named because it was the area where scientists and engineers tested the so-called "gun method" of assembling nuclear materials -- the fundamental design of the Little Boy weapon that was eventually dropped on Hiroshima. The video also goes to Pajarito Site, home of the "Slotin Building" and "Pond Cabin." The Slotin Building is the place where scientist Louis Slotin conducted a criticality experiment that went awry in early 1946, leading to his unfortunate death, and the Pond Cabin served the team of eminent scientist Emilio Segre who did early chemistry work on plutonium that ultimately led to the Fat Man weapon.

  15. Saving Water at Los Alamos National Laboratory

    SciTech Connect

    Erickson, Andy

    2015-03-16

    Los Alamos National Laboratory decreased its water usage by 26 percent in 2014, with about one-third of the reduction attributable to using reclaimed water to cool a supercomputing center. The Laboratory's goal during 2014 was to use only re-purposed water to support the mission at the Strategic Computing Complex. Using reclaimed water from the Sanitary Effluent Reclamation Facility, or SERF, substantially decreased water usage and supported the overall mission. SERF collects industrial wastewater and treats it for reuse. The reclamation facility contributed more than 27 million gallons of re-purposed water to the Laboratory's computing center, a secured supercomputing facility that supports the Laboratory’s national security mission and is one of the institution’s larger water users. In addition to the strategic water reuse program at SERF, the Laboratory reduced water use in 2014 by focusing conservation efforts on areas that use the most water, upgrading to water-conserving fixtures, and repairing leaks identified in a biennial survey.

  16. Estabilidad de los modelos de Heggie y Ramamani

    NASA Astrophysics Data System (ADS)

    Muzzio, J. C.; Vergne, M. M.; Wachlin, F. C.; Carpintero, D. D.

    Los modelos de Heggie y Ramamani de satélites galácticos en órbitas circulares se basan en una teoría aproximada, por lo que es importante verificar su estabilidad mediante simulaciones numéricas. En esta forma, hemos logrado mostrar que son estables sobre intervalos de tiempo mucho mayores que los que lograron los propios autores de los modelos. Por otra parte, dado que hemos mostrado que el caos es significativo en estos modelos, son un sistema ideal para investigar si, pese a ello, se mantienen estacionarios. Nuestras simulaciones numéricas muestran que, pese al caos, la estacionariedad se mantiene sobre intervalos de centenares de tiempos de cruce del sistema, mucho mayores que los tiempos de Liapunov característicos de sus movimientos caóticos.

  17. Field Manual for Museums. Museums and Monuments, XII.

    ERIC Educational Resources Information Center

    Hak, Abdul; And Others

    This manual is intended to provide museum staff throughout the world with basic information needed in organizing field work and adding to their collections, to help museums by stimulating research, and to encourage research personnel to bring a rigorously scientific approach to their investigations. Various specialists in archaeology, ethnography,…

  18. Wood Anatomy of the Neotropical Sapotaceae. XII. Neoxythece.

    DTIC Science & Technology

    1979-01-01

    dura. The longest average of 1.14 mn was from an unassigned specimen (Krukoff 1065). Tyloses commonly sclerotic and usually very abundant in the...3229) ,show ing pa1renchyma deta Ii potr ;in( parencuhyma and sclerotic tyloses Xl 10. arrangement X 30. Figure 7.--Elaeoltima Slabrescens Figure 8

  19. XII Advanced Computing and Analysis Techniques in Physics Research

    NASA Astrophysics Data System (ADS)

    Speer, Thomas; Carminati, Federico; Werlen, Monique

    November 2008 will be a few months after the official start of LHC when the highest quantum energy ever produced by mankind will be observed by the most complex piece of scientific equipment ever built. LHC will open a new era in physics research and push further the frontier of Knowledge This achievement has been made possible by new technological developments in many fields, but computing is certainly the technology that has made possible this whole enterprise. Accelerator and detector design, construction management, data acquisition, detectors monitoring, data analysis, event simulation and theoretical interpretation are all computing based HEP activities but also occurring many other research fields. Computing is everywhere and forms the common link between all involved scientists and engineers. The ACAT workshop series, created back in 1990 as AIHENP (Artificial Intelligence in High Energy and Nuclear Research) has been covering the tremendous evolution of computing in its most advanced topics, trying to setup bridges between computer science, experimental and theoretical physics. Conference web-site: http://acat2008.cern.ch/ Programme and presentations: http://indico.cern.ch/conferenceDisplay.py?confId=34666

  20. Paleomagnetism of Cougar Point Tuff XII, Snake River Plane Idaho

    NASA Astrophysics Data System (ADS)

    Brown, E. D.; Finn, D. R.; Coe, R. S.; Rea-Downing, G. H.; Branney, M. J.; Knott, T.; Reichow, M. K.

    2014-12-01

    Yellowstone hotspot center migration during the mid-Miocene northeast along the Snake River Plain (SRP) resulted in a succession of explosive caldera-forming super-eruptions, often involving 1000's of km3 of ejecta and covering 10,000's of km2. The frequency and volume of the rhyolitic eruptions in the SRP are of both academic and societal interest, yet remain poorly known. Identification and correlation of individual eruption deposits are critical for evaluating eruption volumes and frequency over time and the relationship with climate and tectonics. Rhyolitic ash-flow deposits flank both the northern and southern margins of the SRP, but have not been successfully correlated because of their similarity in both outcrop appearance and chemical composition. Paleomagnetic correlation using the stable magnetic remanence direction has the advantage of very high temporal resolution, on the order of centuries because of the geologically rapid rate of geomagnetic secular variation and the high accuracy in which extrusive volcanic rocks may record the instantaneous direction of the magnetic field. The strength of a paleomagnetic correlation increases with the rarity of the field direction recorded by the ash flow. Here we demonstrate correlation of SRP ignimbrites by sampling the Cougar Point Tuff (CPT) Xll at three widely spaced (~25 km) locations. The transitional polarity recorded by titanomagnetite in CPT Xll enables a strong paleomagnetic correlation. CPT Xll, however, is weakly magnetized because it was erupted during a polarity transition of Earth's magnetic field, and therefore is more susceptible to magnetic overprinting. Nonetheless, careful alternating-field demagnetization coupled with line- fit and great-circle analysis, yields well-constrained directions of stable remanence. Gyroremanent magnetization, a spurious component produced by demagnetization at the higher field steps, is dealt with satisfactorily by taking small alternating-field steps and by permuting the order of demagnetization along the three sample axes.

  1. Division XII: Commission 55: Communicating Astronomy with the Public

    NASA Astrophysics Data System (ADS)

    Christensen, Lars Lindberg; Russo, Pedro; Robson, Ian; Arcand, Kimberly Kowal; Fienberg, Richard Tresch; Ödman-Govender, Carolina; Sekiguchi, Kazuhiro; Wheeler, Pete; Zhu, Jin

    2015-08-01

    A good fraction of the Commission 55 (C55) Organizing Committee met in Beijing in August at the XXVIII IAU General Assembly, where C55 organized Special Session 14 (SpS14) entitled ``Communicating Astronomy with the Public for Scientists.'' During our C55 business meeting, and again during an impromptu gathering a few days later, we discussed changes in the IAU's organizational and programmatic structure and how these changes might affect C55. This report summarizes key points and offers some ideas about what we're calling ``C55 v2.0.'' For background and reference, see the C55 website at http://www.communicatingastronomy.org.

  2. Community College Exemplary Initiatives. Volume XII, 2000-2001.

    ERIC Educational Resources Information Center

    Goss, Donald, Ed.; Goss, Susan, Ed.

    This is the twelfth annual volume of outstanding campus initiatives published by the National Council of Instructional Administrators (NCIA). The volume contains sections corresponding to the five categories in which programs were originally submitted to NCIA for its annual Exemplary Initiatives Awards. Section 1 includes the descriptions of the…

  3. Planck 2015 results. XII. Full focal plane simulations

    NASA Astrophysics Data System (ADS)

    Planck Collaboration; Ade, P. A. R.; Aghanim, N.; Arnaud, M.; Ashdown, M.; Aumont, J.; Baccigalupi, C.; Banday, A. J.; Barreiro, R. B.; Bartlett, J. G.; Bartolo, N.; Battaner, E.; Benabed, K.; Benoît, A.; Benoit-Lévy, A.; Bernard, J.-P.; Bersanelli, M.; Bielewicz, P.; Bock, J. J.; Bonaldi, A.; Bonavera, L.; Bond, J. R.; Borrill, J.; Bouchet, F. R.; Boulanger, F.; Bucher, M.; Burigana, C.; Butler, R. C.; Calabrese, E.; Cardoso, J.-F.; Castex, G.; Catalano, A.; Challinor, A.; Chamballu, A.; Chiang, H. C.; Christensen, P. R.; Clements, D. L.; Colombi, S.; Colombo, L. P. L.; Combet, C.; Couchot, F.; Coulais, A.; Crill, B. P.; Curto, A.; Cuttaia, F.; Danese, L.; Davies, R. D.; Davis, R. J.; de Bernardis, P.; de Rosa, A.; de Zotti, G.; Delabrouille, J.; Delouis, J.-M.; Désert, F.-X.; Dickinson, C.; Diego, J. M.; Dolag, K.; Dole, H.; Donzelli, S.; Doré, O.; Douspis, M.; Ducout, A.; Dupac, X.; Efstathiou, G.; Elsner, F.; Enßlin, T. A.; Eriksen, H. K.; Fergusson, J.; Finelli, F.; Forni, O.; Frailis, M.; Fraisse, A. A.; Franceschi, E.; Frejsel, A.; Galeotta, S.; Galli, S.; Ganga, K.; Ghosh, T.; Giard, M.; Giraud-Héraud, Y.; Gjerløw, E.; González-Nuevo, J.; Górski, K. M.; Gratton, S.; Gregorio, A.; Gruppuso, A.; Gudmundsson, J. E.; Hansen, F. K.; Hanson, D.; Harrison, D. L.; Henrot-Versillé, S.; Hernández-Monteagudo, C.; Herranz, D.; Hildebrandt, S. R.; Hivon, E.; Hobson, M.; Holmes, W. A.; Hornstrup, A.; Hovest, W.; Huffenberger, K. M.; Hurier, G.; Jaffe, A. H.; Jaffe, T. R.; Jones, W. C.; Juvela, M.; Karakci, A.; Keihänen, E.; Keskitalo, R.; Kiiveri, K.; Kisner, T. S.; Kneissl, R.; Knoche, J.; Kunz, M.; Kurki-Suonio, H.; Lagache, G.; Lamarre, J.-M.; Lasenby, A.; Lattanzi, M.; Lawrence, C. R.; Leonardi, R.; Lesgourgues, J.; Levrier, F.; Liguori, M.; Lilje, P. B.; Linden-Vørnle, M.; Lindholm, V.; López-Caniego, M.; Lubin, P. M.; Macías-Pérez, J. F.; Maggio, G.; Maino, D.; Mandolesi, N.; Mangilli, A.; Maris, M.; Martin, P. G.; Martínez-González, E.; Masi, S.; Matarrese, S.; McGehee, P.; Meinhold, P. R.; Melchiorri, A.; Melin, J.-B.; Mendes, L.; Mennella, A.; Migliaccio, M.; Mitra, S.; Miville-Deschênes, M.-A.; Moneti, A.; Montier, L.; Morgante, G.; Mortlock, D.; Moss, A.; Munshi, D.; Murphy, J. A.; Naselsky, P.; Nati, F.; Natoli, P.; Netterfield, C. B.; Nørgaard-Nielsen, H. U.; Noviello, F.; Novikov, D.; Novikov, I.; Oxborrow, C. A.; Paci, F.; Pagano, L.; Pajot, F.; Paoletti, D.; Pasian, F.; Patanchon, G.; Pearson, T. J.; Perdereau, O.; Perotto, L.; Perrotta, F.; Pettorino, V.; Piacentini, F.; Piat, M.; Pierpaoli, E.; Pietrobon, D.; Plaszczynski, S.; Pointecouteau, E.; Polenta, G.; Pratt, G. W.; Prézeau, G.; Prunet, S.; Puget, J.-L.; Rachen, J. P.; Rebolo, R.; Reinecke, M.; Remazeilles, M.; Renault, C.; Renzi, A.; Ristorcelli, I.; Rocha, G.; Roman, M.; Rosset, C.; Rossetti, M.; Roudier, G.; Rubiño-Martín, J. A.; Rusholme, B.; Sandri, M.; Santos, D.; Savelainen, M.; Scott, D.; Seiffert, M. D.; Shellard, E. P. S.; Spencer, L. D.; Stolyarov, V.; Stompor, R.; Sudiwala, R.; Sutton, D.; Suur-Uski, A.-S.; Sygnet, J.-F.; Tauber, J. A.; Terenzi, L.; Toffolatti, L.; Tomasi, M.; Tristram, M.; Tucci, M.; Tuovinen, J.; Valenziano, L.; Valiviita, J.; Van Tent, B.; Vielva, P.; Villa, F.; Wade, L. A.; Wandelt, B. D.; Wehus, I. K.; Welikala, N.; Yvon, D.; Zacchei, A.; Zonca, A.

    2016-09-01

    We present the 8th full focal plane simulation set (FFP8), deployed in support of the Planck 2015 results. FFP8 consists of 10 fiducial mission realizations reduced to 18 144 maps, together with the most massive suite of Monte Carlo realizations of instrument noise and CMB ever generated, comprising 104 mission realizations reduced to about 106 maps. The resulting maps incorporate the dominant instrumental, scanning, and data analysis effects, and the remaining subdominant effects will be included in future updates. Generated at a cost of some 25 million CPU-hours spread across multiple high-performance-computing (HPC) platforms, FFP8 is used to validate and verify analysis algorithms and their implementations, and to remove biases from and quantify uncertainties in the results of analyses of the real data.

  4. Division XII / Commission 14 / Working Group Collision Processes

    NASA Astrophysics Data System (ADS)

    Peach, Gillian; Dimitrijevic, Milan S.

    2012-04-01

    Research in atomic and molecular collision processes and spectral line broadening has been very active since our last report, Peach, Dimitrijević & Stancil 2009. Given the large volume of the published literature and the limited space available, we have attempted to identify work most relevant to astrophysics. Since our report can not be comprehensive, additional publications can be found in the databases at the web addresses listed in the final section. Elastic and inelastic collisions among electrons, atoms, ions, and molecules are included and charge transfer can be very important in collisions between heavy particles.

  5. Environmental Education. Catalogue of Resources for Grades I to XII.

    ERIC Educational Resources Information Center

    Houghton, J. R.

    Environmental education resources are presented in three categories: (1) print materials; (2) non-print materials; and (3) physical resources. The print material category is subdivided into two sections: books, booklets, and card sets; and magazines, reports, and pamphlets. Entries, arranged alphabetically by title within each section, include…

  6. The Path of Carbon in Photosynthesis XII. Some Temperature Effects

    DOE R&D Accomplishments Database

    Ouellet, C.

    1951-06-25

    The photosynthetic assimilation of radioactive carbon dioxide for two-minute periods by Scenedesmus has bee studied at temperatures ranging from 25° to 44° C. All labeled intermediates cease to be formed at about 45° C. With rising temperature, the radioactivity reaching the sugar phosphate reservoirs decreases regularly while there is a sharp maximum in sucrose at 37° C. and a less pronounced one in malic and aspartic acids about 40° C. A tentative interpretation of these effects is offered.

  7. The History of American Journalism. Scholastic Journalism Gazette, Vol. XII.

    ERIC Educational Resources Information Center

    Shuman, James, Ed.

    This collection of 18 brief, informative news stories with datelines from the 18th, 19th, and 20th centuries is intended to provide students with an understanding of how the press has helped to develop and has been the beneficiary of many of the freedoms all Americans enjoy. The collection can also be used in a straight historical context as the…

  8. Mid-Infrared Optoelectronics: Materials and Devices. MIOMD-XII

    DTIC Science & Technology

    2014-10-01

    BRADLEY , Z. IKONIC, R.W. KELSALL, P. HARRISON, S.A. LYNCH, D.J. PAUL, D.D, ARNONE, D.J. ROBBINS, D.NORRIS AND A.G. CULLIS, APPL. PHYS. LETTERS, 1‐3(2002...X. ZHOU, N. ZHANG, M. TERAVEST, D. TANG, J. HOU, S. BERTMAN, M. ALAGHMAND, P. B. SHEPSON, M. A. CARROLL , ET AL., "NITRIC ACID PHOTOLYSIS ON FOREST

  9. Division XII: Commission 14: Atomic and Molecular Data

    NASA Astrophysics Data System (ADS)

    Mashonkina, Lyudmila I.; Salama, Farid; Wahlgren, Glenn M.; Allard, France; Barklem, Paul; Beiersdorfer, Peter; Fraser, Helen; Nave, Gillian; Nilsson, Hampus

    2015-08-01

    The meeting was called to order by the Chair, who followed the agenda that had been sent to the membership prior to the meeting. The membership of the Commission stands at approximately 220 members, excluding the new members who will join the commission at the end of this General Assembly.

  10. Innovation Abstracts: Volume XII, Numbers 1-30, 1990.

    ERIC Educational Resources Information Center

    Roueche, Susanne D., Ed.

    1990-01-01

    This series of one- to two-page abstracts highlights a variety of innovative approaches to teaching and learning in the community college. Topics covered in the abstracts include: (1) academic partnerships pairing "high-risk" students with a concerned faculty member, counselor, or administrator; (2) teacher-to-teacher learning partnerships; (3)…

  11. XII International Symposium on Nuclei in the Cosmos

    NASA Astrophysics Data System (ADS)

    Lattanzio, John; Karakas, Amanda; Lugaro, Maria; Dracoulis, George

    Nuclei in the Cosmos is the most important international meeting in the field of nuclear astrophysics. It brings together nuclear experimentalists, nuclear theorists, astronomers, theoretical astrophysicists, cosmochemists, and others interested in the scientific questions at the interface of nuclear physics and astrophysics. These questions concern, for example, the origin of the elements in the cosmos and the nuclear reactions that occur in the big bang, in stars, and in stellar explosions. Past meetings have been held in Heidelberg - Germany (2010), Mackinac Island - USA (2008), Geneva - Switzerland (2006), Vancouver - Canada (2004), Fuji-Yoshida - Japan (2002), Aarhus - Denmark (2000), Volos - Greece (1998), Notre Dame - USA (1996), Gran Sasso - Italy (1994), Karlsruhe - Germany (1992), Baden bei Wien - Austria (1990).

  12. Communism. Course of Study, Grades IX-XII.

    ERIC Educational Resources Information Center

    Boston Public Schools, MA.

    GRADES OR AGES: Grades 9-12. SUBJECT MATTER: Communism. ORGANIZATION AND PHYSICAL APPEARANCE: The guide has five units: 1) "Historical Background of Communism," which gives a brief chronology of events from Czarist Russia to the present day and outlines the organization of the government and the Communist party; 2) "Communism in Theory and…

  13. Higher Education: Handbook of Theory and Research, Volume XII.

    ERIC Educational Resources Information Center

    Smart, John C., Ed.

    This volume contains nine papers on higher education theory and research. They include: (1) "Technology Transfer from Universities" (Irwin Feller); (2) "State Policy and Private Higher Education: Past, Present and Future" (William Zumeta); (3) "Appraising Tinto's Theory of College Student Departure" (John M. Braxton…

  14. Recent UCN source developments at Los Alamos

    SciTech Connect

    Seestrom, S.J.; Anaya, J.M.; Bowles, T.J.

    1998-12-01

    The most intense sources of ultra cold neutrons (UCN) have bee built at reactors where the high average thermal neutron flux can overcome the low UCN production rate to achieve usable densities of UCN. At spallation neutron sources the average flux available is much lower than at a reactor, though the peak flux can be comparable or higher. The authors have built a UCN source that attempts to take advantage of the high peak flux available at the short pulse spallation neutron source at the Los Alamos Neutron Science Center (LANSCE) to generate a useful number of UCN. In the source UCN are produced by Doppler-shifted Bragg scattering of neutrons to convert 400-m/s neutrons down into the UCN regime. This source was initially tested in 1996 and various improvements were made based on the results of the 1996 running. These improvements were implemented and tested in 1997. In sections 2 and 3 they discuss the improvements that have been made and the resulting source performance. Recently an even more interesting concept was put forward by Serebrov et al. This involves combining a solid Deuterium UCN source, previously studied by Serebrov et al., with a pulsed spallation source to achieve world record UCN densities. They have initiated a program of calculations and measurements aimed at verifying the solid Deuterium UCN source concept. The approach has been to develop an analytical capability, combine with Monte Carlo calculations of neutron production, and perform benchmark experiments to verify the validity of the calculations. Based on the calculations and measurements they plan to test a modified version of the Serebrov UCN factory. They estimate that they could produce over 1,000 UCN/cc in a 15 liter volume, using 1 {micro}amp of 800 MeV protons for two seconds every 500 seconds. They will discuss the result UCN production measurements in section 4.

  15. Methane Hotspots in the Los Angeles Megacity

    NASA Astrophysics Data System (ADS)

    Hopkins, F. M.; Randerson, J. T.; Bush, S.; Ehleringer, J. R.; Lai, C.; Kort, E. A.; Blake, D. R.

    2013-12-01

    Airborne observations show that Los Angeles (LA) is a large source of methane to the atmosphere, yet the sources of excess methane from the urban area are poorly constrained. We used a mobile laboratory, a Ford Transit van equipped with cavity ring down spectrometers (Picarro, Inc.), to measure greenhouse gases (CH4, CO2, and CO) mole fractions in LA. On-road surveys across the LA Basin were conducted seasonally to determine patterns of CH4 enrichment in space and over time, with a focus on quantifying methane leaks from known sources. We found fugitive leaks and elevated CH4 concentrations throughout the LA Basin. Some were associated with known sources, such as landfills, wastewater treatment, and oil and gas infrastructure, while others had an unknown origin. Urban CH4 enrichment varied over the course of the year, largely due to seasonal changes in meteorological conditions. Nevertheless, our mobile surveys revealed CH4 hotspots (>200 ppb elevated with respect to background levels) that persisted among seasons. High CH4 concentrations were most easily predicted by proximity to methane sources, particularly near the coast, while elevated CH4 levels were more evenly dispersed in inland areas. CH4 hotspots had a disproportionate impact on excess methane relative to the area they accounted for, typically providing more than a quarter of excess methane measured on a transect. These data improve estimates of the relative roles of specific leaks and emission sectors to LA's excess methane. Depending on the cost of reducing these CH4 leaks, a focus on CH4 emissions may prove an effective way to reduce LA's greenhouse gas emissions in the near term.

  16. Simulations of flow interactions near Los Alamos

    SciTech Connect

    Costigan, K. R.; Winterkamp, Judy; Bossert, J. E.; Langley, D. L.

    2002-01-01

    The Pajarito Plateau is located on the eastern flank of the Jemez Mountains and the west side of the Rio Grande Valley, in north-central New Mexico, where the river runs roughly north to south. On the Pajarito Plateau, a network of surface meteorological stations has been routinely maintained by Los Alamos National Laboratory. This network includes five instrumented towers, within an approximately 10 km by 15 km area. The towers stand from 23 m to 92 m tall, with multiple wind measurement heights. Investigation of the station records indicates that the wind fields can be quite complicated and may be the result of interactions of thermally and/or dynamically driven flows of many scales. Slope flows are often found on the plateau during the morning and evening transition times, but it is not unusual to find wind directions that are inconsistent with slope flows at some or all of the stations. It has been speculated that valley circulations, as well as synoptically driven winds, interact with the slope flows, but the mesonet measurements alone, with no measurements in the remainder of the valley, were not sufficient to investigate this hypothesis. Thus, during October of 1995, supplemental meteorological instrumentation was placed in the Rio Grande basin to study the complex interaction of flows in the area. A sodar was added near the 92 m tower and a radar wind profiler was placed in the Rio Grande Valley, just east of the plateau and near the river. Measurements were also added at the top of Pajarito Mountain, just west of the plateau, and across the valley, to the east, on top of Tesuque Peak (in the Sangre de Cristo Mountains). Two surface stations were also added to the north-facing slopes of Pajarito Mountain. This paper will present observations from October 1995 and results of simulations of this area that are used in the study of the complex interaction of dynamically and thermally driven flows on multiple scales.

  17. Smog chamber simulation of Los Angeles pollutant transport

    SciTech Connect

    Glasson, W.A.

    1981-06-01

    A smog chamber study simulated pollutant transport from Los Angeles to downwind areas by irradiating a typical Los Angeles hydrocarbon/nitrogen oxides mixture for extended periods of time. Smog chamber experiments were extended to 22 hr to obtain an integrated light intensity equal to that which occurs in this city. Results show that downwind oxidant levels are only slightly affected by large changes in emissions of nitrogen oxides. However, it is clear that reduced emissions will lead to an increase in oxidant in downtown Los Angeles. (6 graphs, 9 references, 1 table)

  18. 11. GRANT LAKE AND MONO LAKE LOOKING NORTH/NORTHEAST Los ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. GRANT LAKE AND MONO LAKE LOOKING NORTH/NORTHEAST - Los Angeles Aqueduct, From Lee Vining Intake (Mammoth Lakes) to Van Norman Reservoir Complex (San Fernando Valley), Los Angeles, Los Angeles County, CA

  19. 10. GRANT LAKE AND MONO LAKE LOOKING EAST/NORTHEAST Los ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. GRANT LAKE AND MONO LAKE LOOKING EAST/NORTHEAST - Los Angeles Aqueduct, From Lee Vining Intake (Mammoth Lakes) to Van Norman Reservoir Complex (San Fernando Valley), Los Angeles, Los Angeles County, CA

  20. 91. FAIRMONT RESERVOIR, LOOKING WEST/NORTHWEST Los Angeles Aqueduct, From ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    91. FAIRMONT RESERVOIR, LOOKING WEST/NORTHWEST - Los Angeles Aqueduct, From Lee Vining Intake (Mammoth Lakes) to Van Norman Reservoir Complex (San Fernando Valley), Los Angeles, Los Angeles County, CA

  1. 83. FIRST AND SECOND AQUEDUCTS LOOKING EAST/NORTHEAST Los Angeles ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    83. FIRST AND SECOND AQUEDUCTS LOOKING EAST/NORTHEAST - Los Angeles Aqueduct, From Lee Vining Intake (Mammoth Lakes) to Van Norman Reservoir Complex (San Fernando Valley), Los Angeles, Los Angeles County, CA

  2. DOE Los Alamos National Laboratory – PV Feasibility Assessment, 2015 Update, NREL Final Report

    SciTech Connect

    Dean, Jesse; Witt, Monica Rene

    2016-04-06

    This report summarizes solar and wind potential for Los Alamos National Laboratory (LANL). This report is part of the “Los Alamos National Laboratory and Los Alamos County Renewable Generation” study.

  3. The Origins of Mexico's Universidad de los Ninos.

    ERIC Educational Resources Information Center

    Levy, Raquel

    1989-01-01

    The article describes an after school program, the Universidad de los Ninos, in Mexico City, for children with special abilities. The program stresses development of individual potential, a flexible curriculum, parent involvement, and development of social responsibility. (DB)

  4. RadNet Air Data From Los Angeles, CA

    EPA Pesticide Factsheets

    This page presents radiation air monitoring and air filter analysis data for Los Angeles, CA from EPA's RadNet system. RadNet is a nationwide network of monitoring stations that measure radiation in air, drinking water and precipitation.

  5. Final Ferry Takes SCA-Endeavour Over Los Angeles

    NASA Video Gallery

    Space shuttle Endeavour atop NASA's Shuttle Carrier Aircraft overflew many landmarks in Los Angeles to conclude its final ferry flight into history on Sept. 21, 2012. Among highlights in this video...

  6. Public Hearing on Cruise Ship Discharges: Los Angeles

    EPA Pesticide Factsheets

    Transcripts of the presentation and comments provided at a hearing hosted by the EPA in Los Angeles, CA on discharges from cruise ships. Stakeholder representatives were in attendance to provide information and recommendations on this issue.

  7. Review of liquid metal heat pipe work at Los Alamos

    SciTech Connect

    Reid, R.S.; Merrigan, M.A.; Sena, J.T.

    1990-01-01

    A survey of space-power related liquid metal heat pipe work at Los Alamos National Laboratory is presented. Heat pipe development at Los Alamos has been on-going since 1963. Heat pipes were initially developed for thermionic nuclear-electrical power production in space. Since then Los Alamos has developed liquid metal heat pipes for numerous applications related to high temperature systems in both the space and terrestrial environments. Some of these applications include thermionic electrical generators, thermoelectric energy conversion (both in-core and direct radiation), thermal energy storage, hypersonic vehicle leading edge cooling, and heat pipe vapor laser cells. Some of the work performed at Los Alamos has been documented in internal reports that are often little-known. A representative description and summary of progress in space-related liquid metal heat pipe technology is provided followed by a reference section citing sources where these works may be found. 53 refs.

  8. Photo Gallery from the Los Angeles River Watershed (California)

    EPA Pesticide Factsheets

    Photo gallery of the Los Angeles River Watershed area of the Urban Waters Federal Partnership (UWFP) reconnects urban communities with their waterways by improving coordination among federal agencies and collaborating with community-led efforts.

  9. Sima de los Huesos (Sierra de Atapuerca, Spain). The site.

    PubMed

    Arsuaga, J L; Martínez, I; Gracia, A; Carretero, J M; Lorenzo, C; García, N

    1997-01-01

    In this article a topographical description of the Cueva Mayor Cueva de Silo cave system is provided, including a more detailed topography of the Sala de los Ciclopes Sala de las Oseras-Sima de los Huesos sector. The history of the excavations and discoveries of human and carnivore fossils in Sima de los Huesos and adjacent passages is briefly reported, as well as the increase, throughout the succeeding field seasons, of the human collection and changes in the relative representation of the different skeletal elements and major biases. The carnivore assemblage structure is also considered. Examining the characteristics of the bone breccia, and the current and ancient karst topography, different alternative accesses are discussed for the accumulation of carnivores and humans in the Sima de los Huesos. Taking into account all the available information, an anthropic origin for the accumulation of human fossils seems to us to be the most likely explanation.

  10. Review of liquid metal heat pipe work at Los Alamos

    SciTech Connect

    Reid, R.S.; Merrigan, M.A.; Sena, J.T. )

    1991-01-10

    A survey of space-power related liquid metal heat pipe work at Los Alamos National Laboratory is presented. Heat pipe development at Los Alamos has been on-going since 1963. Heat pipes were initially developed for thermionic nuclear-electrical power production in space. Since then Los Alamos has developed liquid metal heat pipes for numerous applications related to high temperature systems in both the space and terrestrial environments. Some of these applications include thermionic electrical generators, thermoelectric energy conversion (both in-core and direct radiation), thermal energy storage, hypersonic vehicle leading edge cooling, and heat pipe vapor laser cells. Some of the work performed at Los Alamos has been documented in internal reports that are often little-known. A representative description and summary of progress in space-related liquid metal heat pipe technology is provided followed by a reference section citing sources where these works may be found.

  11. Los Alamos National Laboratory Prepares for Fire Season

    SciTech Connect

    L’Esperance, Manny

    2016-07-18

    Through the establishment of a Wildland Fire Program Office, and the Interagency Fire Base located on Laboratory property, Los Alamos National Laboratory is continuing and improving a program to prepare for wildland fire.

  12. Explosive Flux Compression: 50 Years of Los Alamos Activities

    SciTech Connect

    Fowler, C.M.; Thomson, D.B.; Garn, W.B.

    1998-10-18

    Los Alamos flux compression activities are surveyed, mainly through references in view of space limitations. However, two plasma physics programs done with Sandia National Laboratory are discussed in more detail.

  13. Los Alamos National Laboratory Prepares for Fire Season

    ScienceCinema

    L’Esperance, Manny

    2016-08-10

    Through the establishment of a Wildland Fire Program Office, and the Interagency Fire Base located on Laboratory property, Los Alamos National Laboratory is continuing and improving a program to prepare for wildland fire.

  14. Explosive Flux Compression:. 50 Years of LOS Alamos Activities

    NASA Astrophysics Data System (ADS)

    Fowler, C.; Thomson, D.; Garn, W.

    2004-11-01

    Los Alamos flux compression activities are surveyed, mainly through references in view of space limitations. However, two plasma physics programs done with Sandia National Laboratory are discussed in more detail.

  15. 78 FR 68135 - Environmental Impact Statement: Los Angeles County, California

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-13

    ... Podesta, California Department of Transportation (Caltrans), 100 S. Main Street, Los Angeles, CA 90012, telephone (213) 897-0309 and tami_podesta@dot.ca.gov . SUPPLEMENTARY INFORMATION: Effective July 1,...

  16. Home Tutorials vs. the Public Schools in Los Angeles.

    ERIC Educational Resources Information Center

    Weaver, Roy A.; And Others

    1980-01-01

    Examines the Home Tutorial Program in the San Fernando Valley of California in the areas of organization, parent attitudes, learning environment, achievement, and socialization. Compare the home program with the Los Angeles Unified School District. (IRT)

  17. South Central Los Angeles: A Community in Transition.

    ERIC Educational Resources Information Center

    Lum, Lydia

    2001-01-01

    Discusses how Los Angeles Southwest College perhaps best illustrates the rising tide of Latinos and other minorities sweeping into higher education institutions of deeply steeped Black heritage, and the challenges and new growing pains such schools face. (EV)

  18. Strategic defense initiatives at Los Alamos National Laboratory

    SciTech Connect

    Rockwood, S.D.

    1985-01-01

    This presentation reviews the Strategic Defense Initiative (SDI) programs at Los Alamos National Laboratory, noting especially the needs for and applications of optics and optical technologies. Table I lists the various activities at Los Alamos contributing to SDI programs. The principal, nonnuclear SDI programs are: (1) the free-electron laser, and (2) neutral particle beams. Both should be considered as potential long-range-kill systems, but still in the futuristic category.

  19. Audit of consultant agreements at Los Alamos National Laboratory

    SciTech Connect

    1996-02-23

    The Department of Energy`s (Department) Albuquerque Operations Office (Albuquerque) and Los Alamos National Laboratory (Los Alamos) are responsible for acquiring consulting services in a manner most advantageous to the Government by ensuring adequate competition. Although the Department prefers competitively awarding subcontracts, including consultant agreements, to ensure the lowest possible cost, it allows sole sourcing a subcontract if the sole source is fully justified. The objective of the audit was to determine whether Los Alamos` consultant agreements contained adequate sole source justifications. The audit showed that Los Alamos may not have acquired some of its consultant agreements at the lowest possible cost because it did not prepare adequate sole source justifications for 17 sole source consultant agreements valued at $842,900. This condition existed because: (1) requesters did not follow policies and procedures when preparing sole source justifications, (2) Los Alamos did not have an internal mechanism to reject consultant agreements that were not adequately justified, and (3) the Department did not review consultant agreements to evaluate the adequacy of sole source justifications. Without adequate justifications, the Department cannot be assured that consultant services were obtained at the lowest possible cost. We therefore recommended that the Manager, Albuquerque Operations Office require Los Alamos to ensure proper sole source justifications and enhance internal controls over consultant agreements. Management agreed to implement the recommendations.

  20. Los Angeles: The Most Differentiated Basaltic Martian Meteorite

    NASA Technical Reports Server (NTRS)

    Rubin, Alan E.; Warren, Paul H.; Greenwood, James P.; Verish, Robert S.; Leshin, Laurie A.; Hervig, Richard L.; Clayton, Robert N.; Mayeda, Toshiko K.

    2000-01-01

    Los Angeles is a new martian meteorite that expands the compositional range of basaltic shergottites. Compared to Shergotty, Zagami, QUE94201, and EET79001-B, Los Angeles is more differentiated, with higher concentrations of incompatible elements (e.g., La) and a higher abundance of late-stage phases such as phosphates and K-rich feldspathic glass. The pyroxene crystallization trend starts at compositions more ferroan than in other martian basaits. Trace elements indicate a greater similarity to Shergotty and Zagami than to QUE94201 or EET79001-B, but the Mg/Fe ratio is low even compared to postulated parent melts of Shergotty and Zagami. Pyroxene in Los Angeles has 0.7-4-microns-thick exsolution lamellae, approx. 10 times thicker than those in Shergotty and Zaganii. Opaque oxide compositions suggest a low equilibration temperature at an oxygen fugacity near the fayafite-magnetitequartz buffer. Los Angeles cooled more slowly than Shergotty and Zagami. Slow cooling, coupled with the ferroan bulk composition, produced abundant fine-grained intergrowths of fayalite, hedenbergite, and silica, by the breakdown of pyroxferroite. Shock effects in Los Angeles include maskelynitized plagioclase, pyroxene with mosaic extinction, and rare fault zones. One such fault ruptured a previously decomposed zone of pyroxferroite. Although highly differentiated, the bulk composition of Los Angeles is not close to the low-Ca/Si composition or the globally wind-stirred soil of Mars.

  1. Los Alamos low-level waste performance assessment status

    SciTech Connect

    Wenzel, W.J.; Purtymun, W.D.; Dewart, J.M.; Rodgers, J.E.

    1986-06-01

    This report reviews the documented Los Alamos studies done to assess the containment of buried hazardous wastes. Five sections logically present the environmental studies, operational source terms, transport pathways, environmental dosimetry, and computer model development and use. This review gives a general picture of the Los Alamos solid waste disposal and liquid effluent sites and is intended for technical readers with waste management and environmental science backgrounds but without a detailed familiarization with Los Alamos. The review begins with a wide perspective on environmental studies at Los Alamos. Hydrology, geology, and meteorology are described for the site and region. The ongoing Laboratory-wide environmental surveillance and waste management environmental studies are presented. The next section describes the waste disposal sites and summarizes the current source terms for these sites. Hazardous chemical wastes and liquid effluents are also addressed by describing the sites and canyons that are impacted. The review then focuses on the transport pathways addressed mainly in reports by Healy and Formerly Utilized Sites Remedial Action Program. Once the source terms and potential transport pathways are described, the dose assessment methods are addressed. Three major studies, the waste alternatives, Hansen and Rogers, and the Pantex Environmental Impact Statement, contributed to the current Los Alamos dose assessment methodology. Finally, the current Los Alamos groundwater, surface water, and environmental assessment models for these mesa top and canyon sites are described.

  2. 1993 Northern goshawk inventory on portions of Los Alamos National Laboratory, Los Alamos, NM. Final report

    SciTech Connect

    Sinton, D.T.; Kennedy, P.L.

    1994-06-01

    Northern goshawks (Accipiter gentilis) (hereafter referred to as goshawk) is a large forest dwelling hawk. Goshawks may be declining in population and reproduction in the southwestern United States. Reasons for the possible decline in goshawk populations include timber harvesting resulting in the loss of nesting habitat, toxic chemicals, and the effects of drought, fire, and disease. Thus, there is a need to determine their population status and assess impacts of management activities in potential goshawk habitat. Inventory for the goshawk was conducted on 2,254 ha of Los Alamos National Laboratory (LANL) to determine the presence of nesting goshawks on LANL lands. This information can be incorporated into LANL`s environmental management program. The inventory was conducted by Colorado State University personnel from May 12 to July 30, 1993. This report summarizes the results of this inventory.

  3. Perspective View, SRTM / Landsat, Los Angeles, Calif

    NASA Technical Reports Server (NTRS)

    2002-01-01

    Los Angeles, Calif., is one of the world's largest metropolitan areas with a population of about 15 million people. The urban areas mostly cover the coastal plains and lie within the inland valleys. The intervening and adjacent mountains are generally too rugged for much urban development. This in large part because the mountains are 'young', meaning they are still building (and eroding) in this seismically active (earthquake prone) region.

    Earthquake faults commonly lie between the mountains and the lowlands. The San Andreas fault, the largest fault in California, likewise divides the very rugged San Gabriel Mountains from the low-relief Mojave Desert, thus forming a straight topographic boundary between the top center and lower right corner of the image. We present two versions of this perspective image from NASA's Shuttle Radar Topography Mission (SRTM): one with and one without a graphic overlay that maps faults that have been active in Late Quaternary times (white lines). The fault database was provided by the U.S. Geological Survey.

    For the annotated version of this image, please select Figure 1, below: [figure removed for brevity, see original site] (Large image: 2 mB jpeg)

    The Landsat image used here was acquired on May 4, 2001, about seven weeks before the summer solstice, so natural terrain shading is not particularly strong. It is also not especially apparent given a view direction (northwest) nearly parallel to the sun illumination (shadows generally fall on the backsides of mountains). Consequently, topographic shading derived from the SRTM elevation model was added to the Landsat image, with a false sun illumination from the left (southwest). This synthetic shading enhances the appearance of the topography.

    Landsat has been providing visible and infrared views of the Earth since 1972. SRTM elevation data matches the 30-meter (98-foot) resolution of most Landsat images and substantially helps in analyzing the large and

  4. 76 FR 70051 - Establishment of Class D and Amendment of Class E Airspace; Los Angeles, CA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-10

    ...; Los Angeles, CA AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action establishes Class D airspace at Los Angeles International Airport, Los Angeles, CA. Controlled airspace is necessary to contain potential missed approaches at Los Angeles International Airport....

  5. Environmental assessment for effluent reduction, Los Alamos National Laboratory, Los Alamos, New Mexico

    SciTech Connect

    1996-09-11

    The Department of Energy (DOE) proposes to eliminate industrial effluent from 27 outfalls at Los Alamos National Laboratory (LANL). The Proposed Action includes both simple and extensive plumbing modifications, which would result in the elimination of industrial effluent being released to the environment through 27 outfalls. The industrial effluent currently going to about half of the 27 outfalls under consideration would be rerouted to LANL`s sanitary sewer system. Industrial effluent from other outfalls would be eliminated by replacing once-through cooling water systems with recirculation systems, or, in a few instances, operational changes would result in no generation of industrial effluent. After the industrial effluents have been discontinued, the affected outfalls would be removed from the NPDES Permit. The pipes from the source building or structure to the discharge point for the outfalls may be plugged, or excavated and removed. Other outfalls would remain intact and would continue to discharge stormwater. The No Action alternative, which would maintain the status quo for LANL`s outfalls, was also analyzed. An alternative in which industrial effluent would be treated at the source facilities was considered but dismissed from further analysis because it would not reasonably meet the DOE`s purpose for action, and its potential environmental effects were bounded by the analysis of the Proposed Action and the No Action alternatives.

  6. Environmental Survey preliminary report, Los Alamos National Laboratory, Los Alamos, New Mexico

    SciTech Connect

    Not Available

    1988-01-01

    This report presents the preliminary findings from the first phase of the Environmental Survey of the United States Department of Energy's (DOE) Los Alamos National Laboratory (LANL), conducted March 29, 1987 through April 17, 1987. The Survey is being conducted by an interdisciplinary team of environmental specialists, led and managed by the Office of Environment, Safety and Health's Office of Environmental Audit. Individual team components are outside experts being supplied by a private contractor. The objective of the Survey is to identify environmental problems and areas of environmental risk associated with the LANL. The Survey covers all environmental media and all areas of environmental regulation. It is being performed in accordance with the DOE Environmental Survey Manual. The on-site phase of the Survey involves the review of existing site environmental data, observations of the operations carried on at the LANL, and interviews with site personnel. The Survey team developed Sampling and Analysis Plan to assist in further assessing certain of the environmental problems identified during its on-site activities. The Sampling and Analysis Plan will be executed by the Idaho National Engineering Laboratory. When completed, the results will be incorporated into the LANL Environmental Survey Interim Report. The Interim Report will reflect the final determinations of the Survey for the LANL. 65 refs., 68 figs., 73 tabs.

  7. Ecosystem studies at the Los Medanos site, Eddy County, New Mexico. Volume I

    SciTech Connect

    Hart, J.S.

    1981-05-01

    This report summarizes the results of biological studies conducted during 1980 at the Los Medanos site in southeastern New Mexico. The studies include: (1) densities and species composition of the avifauna of the Los Medanos site; (2) aquatic ecosystems of the lower Pecos drainage; (3) floristic studies at the Los Medanos site; (4) plant successional, grazing, trampling, and salt studies on the Los Medanos site; (5) soil and vegetation studies at the Los Medanos site; (6) arthropod and decomposition studies at the WIPP site; (7) amphibians, reptiles and mammals at the Los Medanos site; (8) vertebrate ecology at the Los Medanos site; and (9) statistical analysis and data management. 7 refs. (ACR)

  8. A progress report on UNICOS misuse detection at Los Alamos

    SciTech Connect

    Thompson, J.L.; Jackson, K.A.; Stallings, C.A.; Simmonds, D.D.; Siciliano, C.L.B.; Pedicini, G.A.

    1995-10-01

    An effective method for detecting computer misuse is the automatic monitoring and analysis of on-line user activity. During the past year, Los Alamos enhanced its Network Anomaly Detection and Intrusion Reporter (NADIR) to include analysis of user activity on Los Alamos` UNICOS Crays. In near real-time, NADIR compares user activity to historical profiles and tests activity against expert rules. The expert rules express Los Alamos` security policy and define improper or suspicious behavior. NADIR reports suspicious behavior to security auditors and provides tools to aid in follow-up investigations. This paper describes the implementation to date of the UNICOS component of NADIR, along with the operational experiences and future plans for the system.

  9. Publications of Los Alamos research, 1977-1981

    SciTech Connect

    Sheridan, C.J.; Garcia, C.A.

    1983-03-01

    This bibliography is a compilation of unclassified publications of work done at the Los Alamos National Laboratory for 1977-1981. Papers published in those years are included regardless of when they were actually written. Publications received too late for inclusion in earlier compilations have also been listed. Declassification of previously classified reports is considered to constitute publication. All classified issuances are omitted - even those papers, themselves unclassified, which were published only as part of a classified document. If a paper was published more than once, all places of publication are included. The bibliography includes Los Alamos National Laboratory reports, papers released as non-Laboratory reports, journal articles, books, chapters of books, conference papers either published separately or as part of conference proceedings issued as books or reports, papers published in congressional hearings, theses, and US patents. Publications by Los Alamos authors that are not records of Laboratory-sponsored work are included when the Library becomes aware of them.

  10. Water Supply at Los Alamos 1998-2001

    SciTech Connect

    Richard J. Koch; David B. Rogers

    2003-03-01

    For the period 1998 through 2001, the total water used at Los Alamos from all sources ranged from 1325 million gallons (Mg) in 1999 to 1515 Mg in 2000. Groundwater production ranged from 1323 Mg in 1999 to 1506 Mg in 2000 from the Guaje, Pajarito, and Otowi fields. Nonpotable surface water used from Los Alamos reservoir ranged from zero gallons in 2001 to 9.3 Mg in 2000. For years 1998 through 2001, over 99% of all water used at Los Alamos was groundwater. Water use by Los Alamos National Laboratory (LANL) between 1998 and 2001 ranged from 379 Mg in 2000 to 461 Mg in 1998. The LANL water use in 2001 was 393 Mg or 27% of the total water use at Los Alamos. Water use by Los Alamos County ranged from 872 Mg in 1999 to 1137 Mg in 2000, and averaged 1006 Mg/yr. Four new replacement wells in the Guaje field (G-2A, G-3A, G-4A, and G-5A) were drilled in 1998 and began production in 1999; with existing well G-1A, the Guaje field currently has five producing wells. Five of the old Guaje wells (G-1, G-2, G-4, G-5, and G-6) were plugged and abandoned in 1999, and one well (G-3) was abandoned but remains as an observation well for the Guaje field. The long-term water level observations in production and observation (test) wells at Los Alamos are consistent with the formation of a cone of depression in response to water production. The water level decline is gradual and at most has been about 0.7 to 2 ft per year for production wells and from 0.4 to 0.9 ft/yr for observation (test) wells. The largest water level declines have been in the Guaje field where nonpumping water levels were about 91 ft lower in 2001 than in 1951. The initial water levels of the Guaje replacement wells were 32 to 57 ft lower than the initial water levels of adjacent original Guaje wells. When production wells are taken off-line for pump replacement or repair, water levels have returned to within about 25 ft of initial static levels within 6 to 12 months. Thus, the water-level trends suggest no adverse

  11. Water supply at Los Alamos during 1993. Progress report

    SciTech Connect

    Purtymun, W.D.; Stoker, A.K.; McLin, S.G.; Maes, M.N.; Glasco, T.A.

    1995-10-01

    This report summarizes production and aquifer conditions for water wells in the Guaje, Pajarito, and Otowi Well Fields. These wells supplied all of the potable water used for municipal and some industrial purposes in Los Alamos County and the Los Alamos National Laboratory during 1993. The wells in the Los Alamos Well Field were transferred to San Ildefonso Pueblo in 1992. Four of the wells in the Los Alamos Well Field were plugged in 1993. One of the two new wells in the Otowi Well Field became operational in 1993. The spring gallery in Water Canyon supplied nonpotable water for industrial use, while surface water from the Los Alamos Reservoir was diverted for irrigation. In 1993 no water was used from the Guaje Reservoir. Due to the maintenance and operating cost of diverting water from the reservoirs, it is not economically feasible to continue their use for irrigation. This report fulfills some of the requirements of the Los Alamos Groundwater Protection Management Program by documenting use of the groundwater for water supply and providing information hydrologic characteristics of the main aquifer. This report is a joint effort between the Laboratory Water Quality and Hydrology Group and the Utilities Department of Johnson Controls World Services Inc. (JCI). The purpose of this report is to ensure a continuing historical record and to provide guidance for management of water resources in long-range planning for the water supply system. We have issued one summary report for the period of 1947 to 1971 and 22 annual reports that contain the results of our studies of these water supplies. An additional report summarized the hydrology of the main aquifer with reference to future development of groundwater supplies. A report was issued in 1988 that examined the status of wells and future water supply.

  12. A physicists guide to The Los Alamos Primer

    NASA Astrophysics Data System (ADS)

    Reed, B. Cameron

    2016-11-01

    In April 1943, a group of scientists at the newly established Los Alamos Laboratory were given a series of lectures by Robert Serber on what was then known of the physics and engineering issues involved in developing fission bombs. Serber’s lectures were recorded in a 24 page report titled The Los Alamos Primer, which was subsequently declassified and published in book form. This paper describes the background to the Primer and analyzes the physics contained in its 22 sections. The motivation for this paper is to provide a firm foundation of the background and contents of the Primer for physicists interested in the Manhattan Project and nuclear weapons.

  13. Fifty-one years of Los Alamos Spacecraft

    SciTech Connect

    Fenimore, Edward E.

    2014-09-04

    From 1963 to 2014, the Los Alamos National Laboratory was involved in at least 233 spacecraft. There are probably only one or two institutions in the world that have been involved in so many spacecraft. Los Alamos space exploration started with the Vela satellites for nuclear test detection, but soon expanded to ionospheric research (mostly barium releases), radioisotope thermoelectric generators, solar physics, solar wind, magnetospheres, astrophysics, national security, planetary physics, earth resources, radio propagation in the ionosphere, and cubesats. Here, we present a list of the spacecraft, their purpose, and their launch dates for use during RocketFest

  14. Los Alamos Using Neutrons to Stop Nuclear Smugglers

    ScienceCinema

    Favalli, Andrea; Swinhoe, Martyn

    2016-07-12

    Los Alamos National Laboratory researchers have successfully demonstrated for the first time that laser-generated neutrons can be enlisted as a useful tool in the War on Terror. The international research team used the short-pulse laser at Los Alamos's TRIDENT facility to generate a neutron beam with novel characteristics that interrogated a closed container to confirm the presence and quantity of nuclear material inside. The successful experiment paves the way for creation of a table-top-sized or truck-mounted neutron generator that could be installed at strategic locations worldwide to thwart smugglers trafficking in nuclear materials.

  15. Los Alamos Using Neutrons to Stop Nuclear Smugglers

    SciTech Connect

    Favalli, Andrea; Swinhoe, Martyn

    2013-06-03

    Los Alamos National Laboratory researchers have successfully demonstrated for the first time that laser-generated neutrons can be enlisted as a useful tool in the War on Terror. The international research team used the short-pulse laser at Los Alamos's TRIDENT facility to generate a neutron beam with novel characteristics that interrogated a closed container to confirm the presence and quantity of nuclear material inside. The successful experiment paves the way for creation of a table-top-sized or truck-mounted neutron generator that could be installed at strategic locations worldwide to thwart smugglers trafficking in nuclear materials.

  16. The development of the atomic bomb, Los Alamos

    SciTech Connect

    Seidel, R.W.

    1993-11-01

    The historical presentation begins with details of the selection of Los Alamos as the site of the Army installation. Wartime efforts of the Army Corps of Engineers, and scientists to include the leader of Los Alamos, Robert Oppenheimer are presented. The layout and construction of the facilities are discussed. The monumental design requirements of the bombs are discussed, including but not limited to the utilization of the second choice implosion method of detonation, and the production of bomb-grade nuclear explosives. The paper ends with a philosophical discussion on the use of nuclear weapons.

  17. A Los Angeles Basin 1100 Aircraft Traffic Model,

    DTIC Science & Technology

    1981-01-01

    air traffic model of the Los Angeles basin for the same year, described in Reference 1. LAX-1100 revises that model by using current air traffic...summarizes the relevant methodology of the original LAX-1840 model. Section 2.2 summarizes the new forecasts used for revising LAX-1840. Section 2.3...ve i’, ’ Lad 1(174, 1096 and 1105 aircraft respectively. 1, 1c ,rc rf t mo.’ was chosen as the revised Los Angeles ’* d CIr va named LAX-i 1(11. L 4

  18. Pilot fruit drier for Los Azufres geothermal field, Michoacan, Mexico

    SciTech Connect

    Lund, J.W.

    1993-02-01

    Comision Federal de Electricidad (CFE) has a Division in charge of the exploration of a geothermal reservoir located in Los Azufres, State of Michoacan. At present, CFE is only using the steam of the wells and rejecting the hot water that comes off associated with the steam. Based on a trip to the Los Azufres geothermal field in December of 1992, a design for a pilot geothermal fruit drier was undertaken for CFE. The details of the geothermal field and the local fruit production are detailed.

  19. Needs assessment for fire department services and resources for the Los Alamos National Laboratory, Los Alamos, New Mexico. Final report

    SciTech Connect

    1995-11-15

    This report has been developed in response to a request from the Los Alamos National Laboratory (LANL) to evaluate the need for fire department services so as to enable the Laboratory to plan effective fire protection and thereby: meet LANL`s regulatory and contractual obligations; interface with the Department of Energy (DOE) and other agencies on matters relating to fire and emergency services; and ensure appropriate protection of the community and environment. This study is an outgrowth of the 1993 Fire Department Needs Assessment (prepared for DOE) but is developed from the LANL perspective. Input has been received from cognizant and responsible representatives at LANL, DOE, Los Alamos County (LAC) and the Los Alamos Fire Department (LAFD).

  20. A survey of macromycete diversity at Los Alamos National Laboratory, Bandelier National Monument, and Los Alamos County; A preliminary report

    SciTech Connect

    Jarmie, N.; Rogers, F.J.

    1997-11-01

    The authors have completed a 5-year survey (1991--1995) of macromycetes found in Los Alamos County, Los Alamos National Laboratory, and Bandelier National Monument. The authors have compiled a database of 1,048 collections, their characteristics, and identifications. The database represents 123 (98%) genera and 175 (73%) species reliably identified. Issues of habitat loss, species extinction, and ecological relationships are addressed, and comparisons with other surveys are made. With this baseline information and modeling of this baseline data, one can begin to understand more about the fungal flora of the area.

  1. Dia de los Muertos: A Joyful Mexican Celebration

    ERIC Educational Resources Information Center

    Markello, Carrie; Bean, Kathy

    2005-01-01

    This brief article describes the history, traditions, and food of the Mexican holiday known as Dia de los Muertos, or the Day of the Day, and explores classroom and studio activities that teachers can do with their students. Teachers are urged to encourage students to explore the topic of the Day of the Dead, comparing it to other traditions and…

  2. Working with Fermi at Chicago and Los Alamos

    NASA Astrophysics Data System (ADS)

    Garwin, Richard L.

    2010-02-01

    I discuss my experience with Enrico Fermi as student and fellow faculty member at Chicago and with him as consultants to the Los Alamos Scientific Laboratory in 1950-1952. The talk shares observations about this great physicist and exemplary human being. )

  3. FINE PORE DIFFUSER FOULING: THE LOS ANGELES STUDIES

    EPA Science Inventory

    This report describes five fine pore diffuser evaluations conducted at three different wastewater treatment plants located in the greater Los Angeles area. The overall goal of the study was to evaluate the performance of fine pore diffusers using selected cleaning methods for ex...

  4. Los Angeles School Board Race Shatters Spending Records

    ERIC Educational Resources Information Center

    Maxwell, Lesli A.

    2013-01-01

    The price tag to win a seat in this week's primary election for the Los Angeles school board climbed to unprecedented levels, as a massive influx of outside cash has turned a local campaign into a national showdown pitting the long-standing influence of teachers' unions against the expanding imprint of deep-pocketed education activists. The high…

  5. The Controlled-Air Incinerator at Los Alamos

    SciTech Connect

    Newmyer, J.N.

    1994-04-01

    The Controlled-Air Incinerator (CAI) at Los Alamos is being modified and upgraded to begin routine operations treating low-level mixed waste (LLMW), radioactively contaminated polychlorinated biphenyl (PCB) wastes, low-level liquid wastes, and possibly transuranic (TRU) wastes. This paper describes those modifications. Routine waste operations should begin in late FY95.

  6. Mercury: The Los Alamos ICF KrF laser system

    SciTech Connect

    Czuchlewski, S.J.; York, G.W.; Bigio, I.J.; Brucker, J.; Hanson, D.; Honig, E.M.; Kurnit, N.; Leland, W.; McCown, A.W.; McLeod, J.; Rose, E.; Thomas, S.; Thompson, D.

    1993-01-19

    The Mercury KrF laser facility at Los Alamos is being built with the benefit of lessons learned from the Aurora system. An increased understanding of KrF laser engineering, and the designed implementation of system flexibility, will permit Mercury to serve as a tested for a variety of advanced KrF technology concepts.

  7. Arts in Focus: Los Angeles Countywide Arts Education Survey.

    ERIC Educational Resources Information Center

    2001

    This report baseline study information about the state of arts education in Los Angeles County, California, the most populous county in the United States. Students in the districts covered in this survey represent 27% of all students enrolled in California public schools (K-12) and 3.4% of all students enrolled in U.S. public schools. The survey's…

  8. AmeriFlux US-Los Lost Creek

    DOE Data Explorer

    Desai, Ankur [University of Wisconsin

    2016-01-01

    This is the AmeriFlux version of the carbon flux data for the site US-Los Lost Creek. Site Description - Shrub wetland site, chosen to be representative of the wetlands within the WLEF tall tower flux footprint. This is a deciduous shrub wetland. Coniferous and grassy stands also exist within the WLEF flux footprint. Solar power. The site has excellent micrometeorological characteristics.

  9. Utilice en forma segura los productos con cebo para roedores

    EPA Pesticide Factsheets

    Si se usan de manera inadecuada, los productos con veneno para ratas y ratones podrían hacerle daño a usted, a sus hijos o a sus mascotas. Siempre que use pesticidas lea la etiqueta del producto y siga todas las indicaciones.

  10. Linking Planning, Quality Improvement and IR: Los Angeles City College

    ERIC Educational Resources Information Center

    Seymour, Daniel

    2004-01-01

    Stung by a negative accreditation review, Los Angeles City College established an administrative position and a planning process that is successfully creating a culture of continuous improvement. At the core of this success is a "plan-act-check" reinforcing systems loop that links planning, budgeting, and institutional research. (Contains 2…

  11. Working Smart: The Los Angeles Workplace Literacy Project. Final Report.

    ERIC Educational Resources Information Center

    Los Angeles Unified School District, CA. Div. of Adult and Occupational Education.

    The Working Smart workplace literacy project was sponsored by a public school district and several profit and nonprofit companies and conducted for the hotel and food industry in the Los Angeles area. Literacy instruction was merged with job requirements of the customer service job classifications. Videodisc courseware was developed, as were…

  12. Asi Son los Puertorriquenos (These Are the Puerto Ricans).

    ERIC Educational Resources Information Center

    Kane, Joan K.

    "Asi Son los Puertorriquenos" immerses the student of Spanish in the language and culture of Puerto Rico. The program is designed to simultaneously improve language skills and develop understanding and appreciation of the culture. The reading selections are challenging for the intermediate level, and provide valuable insight into many…

  13. 40. Topeka and Santa Fe Railway Company, Los Angeles, California, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    40. Topeka and Santa Fe Railway Company, Los Angeles, California, dated July 1937. (Microfiched drawings located at the Denver Service Center, #113/41906-set of 2) IMPROVEMENTS IN SEWAGE TREATMENT AND FILTER CHAMBER. - Water Reclamation Plant, Grand Canyon, Coconino County, AZ

  14. Demographic Paradoxes in the Los Angeles Voting Rights Case.

    ERIC Educational Resources Information Center

    Clark, William A. V.; Morrison, Peter A.

    1991-01-01

    How technical demographic analysis can inform and confuse judicial considerations of voting rights principles is illustrated in a review of a 1990 case brought against Los Angeles County (California). A postscripted article considers whether the court involved should rely on after-census estimates for redistricting. (SLD)

  15. The Los Alamos nuclear safeguards and nonproliferation technology development program

    SciTech Connect

    Smith, H.A. Jr.; Menlove, H.O.; Reilly, T.D.; Bosler, G.E.; Hakkila, E.A.; Eccleston, G.W.

    1994-04-01

    For nearly three decades, Los Alamos National Laboratory has developed and implemented nuclear measurement technology and training in support of national and international nuclear safeguards. This paper outlines the major elements of those technologies and highlights some of the latest developments.

  16. Drop Out Patterns in the East Los Angeles Community College

    ERIC Educational Resources Information Center

    Waktola, Daniel K.

    2014-01-01

    This study attempted to analyze the drop out problem from spatial perspectives within the context of East Los Angeles Community College, California. Selected urban land-use types, which positively and negatively influence the propensity to drop out or persist-in colleges, were selected and captured during a global positioning system (GPS)-based…

  17. Desentrañar los secretos de Mercurio

    NASA Video Gallery

    De todos los planetas rocosos, Mercurio es el más pequeño y denso, el que posee la superficie más antigua y el que tiene las variaciones diarias de temperatura más amplias. También es el menos expl...

  18. Plasma and ion beam processing at Los Alamos

    SciTech Connect

    Rej, D.J.; Davis, H.A.; Henins, I.

    1994-07-01

    Efforts are underway at Los Alamos National Laboratory to utilize plasma and intense ion beam science and technology of the processing of advanced materials. A major theme involves surface modification of materials, e.g., etching, deposition, alloying, and implantation. In this paper, we concentrate on two programs, plasma source ion implantation and high-intensity pulsed ion beam deposition.

  19. [Los Alamos National Laboratory industrial applications and technology transfer

    SciTech Connect

    Not Available

    1992-09-30

    In October 1989, the Los Alamos Economic Development Corporation (LAEDC) entered into a contract with the Industrial Applications office (IAO) of Los Alamos National Laboratory (LANL) whereby the LAEDC was to provide support services to IAO. More specifically, according to the Statement of Work in this contract The Los Alamos Economic Development Corporation shall assist the Los Alamos National Laboratory Industrial Applications Office in establishing and strengthening connections between potential entrepreneurs at the Laboratory and the business assistance community throughout New Mexico, directed toward enhancing the number, of successful start up businesses spinning off the Laboratory's technology base.'' As part of this contract and subsequent modifications thereof, the LAEDC was to perform seven tasks: 1. Provide business planning assistance to potential entrepreneurs. 2. (Assist IAO in preparing and distributing) informational materials on technology transfer. 3. (Organize and manage) meetings and seminars on technology transfer and entrepreneurship. 4. Identify new opportunities for technology transfer. 5. (Identify and implement programs for the) recognition of Laboratory Entrepreneurs. 6. Training Lab personnel, in the area of technology transfer and Laboratory industrial interactions. 7. Review and summarize prior New Mexico economic development studies. The purpose of this report, is to summarize the accomplishments of the LAEDC under its contract with IAO, and to fulfill its reporting requirements. This report covers the period from October 1989 to September 1992.

  20. Urban America: Policy Choices for Los Angeles and the Nation.

    ERIC Educational Resources Information Center

    Steinberg, James B., Ed.; And Others

    This volume presents 13 essays on urban problems in the United States, particularly in Los Angeles (California) following the 1992 riots, and policy options for the future. Part 1 addresses policies of the past three decades; Part 2 looks at children, youth, and families; Part 3 discusses crime and criminal justice; and Part 4 examines public…

  1. Housing in Los Angeles: Affordable Housing for the Future.

    ERIC Educational Resources Information Center

    Los Angeles Blue Ribbon Committee for Affordable Housing, CA.

    A 1988 mayoral committee assessed the seriousness of Los Angeles (California) housing problems and found that the city's housing efforts were sufficient in the 1960s, when the Federal Government took primary responsibility for housing and the average wage was adequate to support the cost of the average house or apartment. However, the following…

  2. The Widening Divide: Income Inequality and Poverty in Los Angeles.

    ERIC Educational Resources Information Center

    Castellanos, Eulalio; And Others

    This document summarizes findings from the Research Project on Income Inequality and Poverty in Los Angeles. The figures reported are based on an analysis of published and unpublished data sets, including the Public Use Microdata Sets for the 1970 and 1980 decennial Census of Population, the Current Population Surveys, and the American Housing…

  3. State of the District [Los Angeles Community College District].

    ERIC Educational Resources Information Center

    Koltai, Leslie

    Accomplishments made by the Los Angeles Community College District during its fifth year of independent operation are noted, and 10 projects to receive attention during the coming year are listed. The accomplishments are: (1) increasing and diversifying enrollment, (2) stabilizing and improving the college environment, (3) developing fiscal…

  4. Los Angeles Community College District Annual Report, 1993.

    ERIC Educational Resources Information Center

    Los Angeles Community Coll. District, CA.

    This 1993 annual report provides information on student demographics, college programs, and educational finances in the Los Angeles Community College District (LACCD), which, with more than 117,000 students, is the largest community college district in the nation. The report begins with a statement from Donald Phelps, the outgoing chancellor of…

  5. SOFT FLOOR COVERING IN THE LOS ANGELES CITY SCHOOL DISTRICTS.

    ERIC Educational Resources Information Center

    CUNLIFF, DONALD D.

    A STUDY REGARDING THE INSTALLATION OF CARPET IN SCHOOLS IS DISCUSSED. THE PURPOSE OF THE STUDY WAS TO HAVE A CONSULTANT REVIEW UNDER THE DIRECTION OF THE DISTRICT BUILDING AND GROUNDS SERVICES ADMINISTRATOR OF THE LOS ANGELES CITY SCHOOL DISTRICTS, THE SOFT FLOOR COVERING INSTALLATIONS AT ARAGON AVENUE AND TWENTY-FOURTH STREET SCHOOLS. SECTIONS…

  6. Aqueous Nitrate Recovery Line at Los Alamos National Laboratory

    SciTech Connect

    Finstad, Casey Charles

    2016-06-15

    This powerpoint is part of the ADPSM Plutonium Engineering Lecture Series, which is an opportunity for new hires at LANL to get an overview of work done at TA55. It goes into detail about the aqueous nitrate recovery line at Los Alamos National Laboratory.

  7. Food Buying Practices of Mexican Americans in East Los Angeles.

    ERIC Educational Resources Information Center

    Lewis, Jane S.; And Others

    As part of a pilot study of the nutritional status of Mexican American preschool children attending Head Start in East Los Angeles in the spring of 1969, questions were asked concerning their families' buying and food practices. This paper reports on the information obtained from the 21 questionnaires which were returned. Answers to the following…

  8. Brief review of Rover fuel development at Los Alamos

    NASA Technical Reports Server (NTRS)

    Davidson, Keith V.

    1991-01-01

    A brief review of the graphite matrix uranium fuel development efforts at Los Alamos from 1955 through 1972 is presented. The uses of graphite flour carbon black, various binders, uranium dioxide, coated UC2 particles, and zirconium carbide in this development are described.

  9. American Indian Voluntary Associations in Greater Los Angeles: An Overview.

    ERIC Educational Resources Information Center

    Bramstedt, Wayne

    With its large and heterogeneous Indian population, the Los Angeles area offers an excellent opportunity to study patterns in the origin, growth, and structure of Indian voluntary associations, and the leisure time institutions. Since the 1920's more than 100 Indian voluntary associations formed in the area. Established groups influenced the…

  10. Instructional Practices in Los Angeles Universal Preschool. Final Report

    ERIC Educational Resources Information Center

    Atkins-Burnett, Sally; Xue, Yange; Kopack, Ashley; Induni, Marta; Moiduddin, Emily

    2010-01-01

    As part of Phase 3 of the Universal Preschool Child Outcomes Study (UPCOS-3), Mathematica Policy Research worked with the First 5 LA Children and Families Commission and Los Angeles Universal Preschool (LAUP) to conduct a descriptive study of the characteristics of classrooms in LAUP programs during winter 2010. This study has a particular focus…

  11. Los Angeles Community Colleges Student Characteristics, Fall 1996.

    ERIC Educational Resources Information Center

    Tillberg, Rebecca; And Others

    This report presents data and tables on student characteristics for the Los Angeles Community Colleges for fall 1996. Data for the following categories is presented for each college: a descriptive summary, age by gender and age by ethnicity, ethnicity by gender and ethnicity by citizenship, unit load by gender and hour load by gender, unit load by…

  12. Los Angeles Community College District Annual Report, 1990.

    ERIC Educational Resources Information Center

    Los Angeles Community Coll. District, CA.

    This annual report on the Los Angeles Community College District (LACCD) contains demographic and enrollment profiles of the nine colleges that compose the LACCD as well as a systemwide budget, and districtwide student characteristics. Following messages from the LACCD president and chancellor, the report contains profiles of the following…

  13. Summary of environmental surveillance at Los Alamos during 1995

    SciTech Connect

    1996-10-01

    Linking the Rio Grande Valley and the Jemez Mountains, New Mexico`s Pajarito Plateau is home to a world-class scientific institution. Los Alamos National Laboratory (or the Laboratory), managed by the Regents of the University of California, is a government-owned, Department of Energy-supervised complex investigating all areas of modern science for the purposes of national defense, health, conservation, and ecology. The Laboratory was founded in 1943 as part of the Manhattan Project, whose members assembled to create the first nuclear weapon. Occupying the campus of the Los Alamos Ranch School, American and British scientists gathered on the isolated mesa tops to harness recently discovered nuclear power with the hope of ending World War II. In July 1945, the initial objective of the Laboratory, a nuclear device, was achieved in Los Alamos and tested in White Sands, New Mexico. Today the Laboratory continues its role in defense, particularly in nuclear weapons, including developing methods for safely handling weapons and managing waste. For the past twenty years, the Laboratory has published an annual environmental report. This pamphlet offers a synopsis that briefly explains important concepts, such as radiation and provides a summary of the monitoring results and regulatory compliance status that are explained at length in the document entitled Environmental Surveillance at Los Alamos during 1995.

  14. 23. Photocopy of original photo from Corps of Engineers, Los ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    23. Photocopy of original photo from Corps of Engineers, Los Angeles District, 'Report on Salinas Dam, Salinas River, California,' June 15, 1943. (Photographer unknown; report located at City of San Luis Obispo.) CONSTRUCTION PHOTO SHOWING CURVED CONCRETE CHUTE SPILLWAY. - Salinas Dam, Salinas River near Pozo Road, Santa Margarita, San Luis Obispo County, CA

  15. 22. Photocopy of original photo from Corps of Engineers, Los ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    22. Photocopy of original photo from Corps of Engineers, Los Angeles District, 'Report on Salinas Dam, Salinas River, California,' June 15, 1943. (Photographer unknown; report located at City of San Luis Obispo.) CONSTRUCTION PHOTO SHOWING THE STRUTS, POURED TO ALIGN WITH THE RIGHT (WEST) BUTTRESS. - Salinas Dam, Salinas River near Pozo Road, Santa Margarita, San Luis Obispo County, CA

  16. 24. Photocopy of original photo from Corps of Engineers, Los ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    24. Photocopy of original photo from Corps of Engineers, Los Angeles District, 'Report on Salinas Dam, Salinas River, California,' June 15, 1943. (Photographer unknown, report located at City of San Luis Obispo.) SALINAS DAM COMPLETION PHOTO. - Salinas Dam, Salinas River near Pozo Road, Santa Margarita, San Luis Obispo County, CA

  17. 21. Photocopy of original photo from Corps of Engineers, Los ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    21. Photocopy of original photo from Corps of Engineers, Los Angeles District, 'Report on Salinas Dam, Salinas River, California,' June 15, 1943. (Photographer unknown; report located at City of San Luis Obispo.) SALINAS DAM UNDER CONSTRUCTION IN 1941. - Salinas Dam, Salinas River near Pozo Road, Santa Margarita, San Luis Obispo County, CA

  18. Dia de los Muertos: An Illustrated Essay and Bibliography.

    ERIC Educational Resources Information Center

    California Univ., Santa Barbara. University Library.

    Among Mexico's most original traditions is the holiday dedicated to honoring the dead, Dia de los Muertos, November 2. This tradition combines aspects that define the national spirit. At the same time that it is a solemn festivity to remember the dead, it becomes a fiesta in its own right. Death, more than a thing to be feared, becomes the motif…

  19. Los ojos de la NASA sobre la Tierra

    NASA Video Gallery

    La NASA cuenta con más de una decena de satélites que estudian la Tierra. Conoce la información que recaban los satélites, junto con Gilberto Colón, asistente especial del subdirector del Centro de...

  20. Was all that Los Angeles River flood control concrete necessary?

    NASA Astrophysics Data System (ADS)

    Patzert, W. C.; Regalado, S. S.; LaDochy, S.; Ramirez, P. C.; Willis, J. K.

    2014-12-01

    In 1938, heavy rains over the Los Angeles Basin resulted in widespread and costly flooding of the Los Angeles River floodplain. In response to the resultant damage, 51 miles of the River was concreted from the San Fernando Valley to the Pacific Ocean. Today proposals to modify the river to capture more water and to restore it to a more natural state have been approved. Through comparison of rainfall data, we test whether channelization can adequately handle the extreme flooding events occurring since 1938. Between February 27th to March 3rd 1938, two major storms resulted in 14.1 inches of rain in Pasadena, CA leading to the flooding of the Los Angeles River, 115 fatalities, the destruction of 5,601 buildings, and to $627 million (2011 dollars) in damages. Downtown Los Angeles averages 15 inches of precipitation a year, while the San Gabriel Mountains, where most of the Los Angeles River watershed rainfall is collected, typically receive more than 40 inches of rain annually. Eight record storms, each with rainfall totals over 11 inches, since the 1938 flood could have created devastating deluges were it not for channelization. Presently, at full stage the channelized Los Angeles River can accommodate a discharge of 129,000 cfs. During the 1938 flood event the discharge peaked at 68,000 cfs above Arroyo Seco and 79,000 cfs below Firestone Blvd. A similar storm event today would have led to increased discharge due to urbanization. Since 1938, the greatest discharge recorded at the same stations was 52,200 and 74,400 cfs during the February 16th 1980 storm. Although damage was substantial during this storm, river channelization prevented fatalities and much damage. To date, the channelization of the Los Angeles River has been successful in flood control. However, our research shows that southern California precipitation is becoming more intense which may result in increased flooding. Any future modifications to the river must be prepared to handle the extreme flooding

  1. Hate Crime in Los Angeles County 1990. A Report to the Los Angeles County Board of Supervisors.

    ERIC Educational Resources Information Center

    Hatcher, Bunny Nightwalker

    A report on 1990 hate crimes in Los Angeles County (California) found 275 racially motivated hate crimes, 150 religiously motivated hate crimes, and 125 sexual orientation hate crimes. The data were collected primarily from law enforcement and community agencies. Of the racially motivated crimes, most were aimed at Blacks, followed by Asians. Jews…

  2. Los cambios en la velocidad de rotación terrestre y los fenómenos geomagnéticos

    NASA Astrophysics Data System (ADS)

    Gianibelli, J. C.

    Uno de los aspectos importantes relativos a la geodinámica del interior terrestre es la correlación entre los eventos de cambio en la velocidad de rotación terrestre y los determinados en los elementos del campo geomagnético por ejemplo, la Declinación Magnética, o los coeficientes de los modelos matemáticos de representación global de dicho campo. En este trabajo se presentan los resultados de las características espectrales de los cambios observados en la longitud del día (ldd), y su relación con la estructura espectral de las coeficientes de los modelos matemáticos de campo denominados Campo Internacional Geomagnético de Referencia (CIGR). El intervalo estudiado comprende los últimos 100 años. Los resultados muestran una correlación en las bandas de 60 y 30 años, con posibles períodos mucho mayores que no son posibles determinar a partir de los modelos de CIRG. Se efectúa una simulación a partir de los resultados obtenidos por la aplicación del método de máxima entropía con longitudes del filtro predictor de error comprendida entre el 10% y el 95% de la longitud de la serie analizada. Se observan procesos sicrónicos y asincrónicos que, en muy largos intervalos de tiempos, podrían suponerse como caóticos.

  3. Penetrating radiation: applications at Los Alamos National Laboratory

    NASA Astrophysics Data System (ADS)

    Watson, Scott; Hunter, James; Morris, Christopher

    2013-09-01

    Los Alamos has used penetrating radiography extensively throughout its history dating back to the Manhattan Project where imaging dense, imploding objects was the subject of intense interest. This interest continues today as major facilities like DARHT1 have become the mainstay of the US Stockpile Stewardship Program2 and the cornerstone of nuclear weapons certification. Meanwhile, emerging threats to national security from cargo containers and improvised explosive devices (IEDs) have invigorated inspection efforts using muon tomography, and compact x-ray radiography. Additionally, unusual environmental threats, like those from underwater oil spills and nuclear power plant accidents, have caused renewed interest in fielding radiography in severe operating conditions. We review the history of penetrating radiography at Los Alamos and survey technologies as presently applied to these important problems.

  4. The engineering institute of Los Alamos National Laboratory

    SciTech Connect

    Farrar, Charles R; Park, Gyuhae; Cornwell, Phillip J; Todd, Michael D

    2008-01-01

    Los Alamos National Laboratory (LANL) and the University of California, San Diego (UCSD) have taken the unprecedented step of creating a collaborative, multi-disciplinary graduate education program and associated research agenda called the Engineering Institute. The mission of the Engineering Institute is to develop a comprehensive approach for conducting LANL mission-driven, multidisciplinary engineering research and to improve recruiting, revitalization, and retention of the current and future staff necessary to support the LANL' s national security responsibilities. The components of the Engineering Institute are (1) a joint LANL/UCSD degree program, (2) joint LANL/UCSD research projects, (3) the Los Alamos Dynamic Summer School, (4) an annual workshop, and (5) industry short courses. This program is a possible model for future industry/government interactions with university partners.

  5. A NEW GENERATION OF LOS ALAMOS OPACITY TABLES

    SciTech Connect

    Colgan, J.; Kilcrease, D. P.; Magee, N. H.; Sherrill, M. E.; Abdallah, J. Jr.; Hakel, P.; Fontes, C. J.; Guzik, J. A.; Mussack, K. A.

    2016-02-01

    We present a new, publicly available set of Los Alamos OPLIB opacity tables for the elements hydrogen through zinc. Our tables are computed using the Los Alamos ATOMIC opacity and plasma modeling code, and make use of atomic structure calculations that use fine-structure detail for all the elements considered. Our equation of state model, known as ChemEOS, is based on the minimization of free energy in a chemical picture and appears to be a reasonable and robust approach to determining atomic state populations over a wide range of temperatures and densities. In this paper we discuss in detail the calculations that we have performed for the 30 elements considered, and present some comparisons of our monochromatic opacities with measurements and other opacity codes. We also use our new opacity tables in solar modeling calculations and compare and contrast such modeling with previous work.

  6. Los Azufres geothermal field: Observed response after 12-year exploitation

    SciTech Connect

    Maldonado, G.J.

    1995-12-31

    Exploitation of the Los Azufres Geothermal field was initiated in August 1982, with the electric power generation of five 5-MW wellhead units. Since then another 70 MW have been installed. A large amount of information has been compiled, including geologic, geochemical, production, and reservoir characteristics. The data were evaluated to detect the extent of observable changes in the main reservoir parameters over the twelve-year production period. Pressure and temperature measurements in Los Azufres wells show that geothermal fluid distribution is strongly influenced by the presence of permeable structures. Wellhead production and chemical analysis of the separated brine show that we are dealing with a highly heterogeneous reservoir, were the drawdown and enthalpy changes depend on the position of the well being studied.

  7. A New Generation of Los Alamos Opacity Tables

    SciTech Connect

    Colgan, James Patrick; Kilcrease, David Parker; Magee, Jr., Norman H.; Sherrill, Manolo Edgar; Abdallah, Joseph; Hakel, Peter; Fontes, Christopher John; Guzik, Joyce Ann; Mussack Tamashiro, Kathleen Anita

    2016-01-26

    We present a new, publicly available, set of Los Alamos OPLIB opacity tables for the elements hydrogen through zinc. Our tables are computed using the Los Alamos ATOMIC opacity and plasma modeling code, and make use of atomic structure calculations that use fine-structure detail for all the elements considered. Our equation-of-state (EOS) model, known as ChemEOS, is based on the minimization of free energy in a chemical picture and appears to be a reasonable and robust approach to determining atomic state populations over a wide range of temperatures and densities. In this paper we discuss in detail the calculations that we have performed for the 30 elements considered, and present some comparisons of our monochromatic opacities with measurements and other opacity codes. We also use our new opacity tables in solar modeling calculations and compare and contrast such modeling with previous work.

  8. A New Generation of Los Alamos Opacity Tables

    DOE PAGES

    Colgan, James Patrick; Kilcrease, David Parker; Magee, Jr., Norman H.; ...

    2016-01-26

    We present a new, publicly available, set of Los Alamos OPLIB opacity tables for the elements hydrogen through zinc. Our tables are computed using the Los Alamos ATOMIC opacity and plasma modeling code, and make use of atomic structure calculations that use fine-structure detail for all the elements considered. Our equation-of-state (EOS) model, known as ChemEOS, is based on the minimization of free energy in a chemical picture and appears to be a reasonable and robust approach to determining atomic state populations over a wide range of temperatures and densities. In this paper we discuss in detail the calculations thatmore » we have performed for the 30 elements considered, and present some comparisons of our monochromatic opacities with measurements and other opacity codes. We also use our new opacity tables in solar modeling calculations and compare and contrast such modeling with previous work.« less

  9. A new generation of Los Alamos opacity tables

    NASA Astrophysics Data System (ADS)

    Colgan, J.; Kilcrease, D. P.; Magee, N. H.; Abdallah, J.; Sherrill, M. E.; Fontes, C. J.; Hakel, P.; Guzik, J. A.; Mussack, K. A.; Walczak, P.

    2017-03-01

    We review a recently completed set of Los Alamos OPLIB opacity tables for the elements hydrogen through zinc. Our tables have been computed using the Los Alamos ATOMIC code, which makes use of atomic structure calculations that include fine-structure detail for all the elements considered. We utilize an equation-of-state model, known as ChemEOS, that is based on the minimization of free energy in a chemical picture. Recent publications by us have compared our calculations to available experimental opacity data and to other opacity calculations. Our tables are publicly available via our website, and have already been used in solar modeling calculations as well as the modeling of pulsating B-type stars. This proceedings submission will give an overview of our opacity calculations and briefly review the conclusions from the astrophysical modeling.

  10. Tiger Team Assessment of the Los Alamos National Laboratory

    SciTech Connect

    Not Available

    1991-11-01

    This report documents the Tiger Team Assessment of the Los Alamos National Laboratory (LANL) located in Los Alamos, New Mexico. LANL is operated for the US Department of Energy (DOE) by the University of California. The Tiger Team Assessment was conducted from September 23 to November 8, 1991, under the auspices of the DOE Office of Special Projects, Office of Assistant Secretary for Environment, Safety and Health. The assessment was comprehensive, encompassing environmental, safety, and health (ES H) disciplines; management; and contractor and DOE self-assessments. Compliance with applicable Federal, state, and local regulations; applicable DOE Orders; best management practices; and internal LANL site requirements was assessed. In addition, an evaluation of the adequacy and effectiveness of the DOE and the site contractors' management of ES H/quality assurance programs was conducted. This volume discusses findings concerning the environmental assessment.

  11. Un Puente A Los Cielos -- A Bridge To The Skies

    NASA Astrophysics Data System (ADS)

    Dyer, K. K.; Harrison, R. J.; Poindexter, A. C.

    2003-12-01

    Un Puente A Los Cielos is an outreach project targeted at Socorro High School students and Spanish-speaking population of the Americas. The project took place over the summer of 2003 during which six Socorro High School students and their supervisor spent the summer exploring the astronomical community at the National Radio Astronomy Observatory and across New Mexico while translating web pages on astronomy for the general public into Spanish. We describe the project and highlight both the successes and unexpected complications and discuss methods of evaluating the impact of the project on the high school students and on the Spanish-speaking community. Un Puente A Los Cielos is funded through NASA IDEAS grant HST-ED-90245.01-A. KKD is supported by an NSF Astronomy and Astrophysics Postdoctoral Fellowship under award AST-0103879.

  12. Sustainable Hydrogen Fueling Station, California State University, Los Angeles

    SciTech Connect

    Blekhman, David

    2013-01-25

    The College of Engineering, Computer Science, & Technology at California State University, Los Angeles as part of its alternative and renewable energy leadership efforts has built a sustainable hydrogen station to teach and demonstrate the production and application of hydrogen as the next generation of fully renewable fuel for transportation. The requested funding was applied toward the acquisition of the core hydrogen station equipment: electrolyzer, compressors and hydrogen storage.

  13. Los Alamos x-ray characterization facilities for plasma diagnostics

    SciTech Connect

    Day, R.H.; Blake, R.L.; Stradling, G.L.; Trela, W.J.; Bartlett, R.J.

    1986-01-01

    A summary is given of characteristics of x-ray sources used by Los Alamos National Laboratory to calibrate various x-ray diagnostic packages and components. Included are D.C. sourcs in electron impact and fluorescence modes, a pulsed laser source for soft x rays with 100 ps time resolution, Febetron pulsed electron impact sources, and both EUV and x-ray synchrotron beamlines.

  14. Los Alamos National Laboratory's high-performance data system

    SciTech Connect

    Mercier, C.; Chorn, G.; Christman, R.; Collins, B.

    1991-01-01

    Los Alamos National Laboratory is designing a High-Performance Data System (HPDS) that will provide storage for supercomputers requiring large files and fast transfer speeds. The HPDS will meet the performance requirements by managing data transfers from high-speed storage systems connected directly to a high-speed network. File and storage management software will be distributed in workstations. Network protocols will ensure reliable, wide-area network data delivery to support long-distance distributed processing. 3 refs., 2 figs.

  15. The Cerro LOS Calvos and La Banderia chondrites

    NASA Astrophysics Data System (ADS)

    Whitlock, Randall; Lewis, Charles F.; Clark, James C.; Moore, Carleton B.

    1991-06-01

    The Cerro los Calvos meteorite is a single stone of 68.5 g found in the Nuevo Mercurio strewn field of Zacatecas, (Mexico). It is an unusual H4 chondrite. Its olivine (Fa12.5) and orthopyroxene (Fs 11.7, Wo 0.8) are reduced relative to typical H chondrites. The La Banderia meteorite of 54.3 g from the same vicinity is an LL5 chondrite of shock classification e.

  16. Recent results in the Los Alamos compact torus program

    SciTech Connect

    Tuszewski, M.; Armstrong, W.T.; Barnes, C.W.

    1983-01-01

    A Compact Toroid is a toroidal magnetic-plasma-containment geometry in which no conductors or vacuum-chamber walls pass through the hole in the torus. Two types of compact toroids are studied experimentally and theoretically at Los Alamos: spheromaks that are oblate in shape and contain both toroidal and poloidal magnetic fields, and field-reversed configurations (FRC) that are very prolate and contain poloidal field only.

  17. [Los Alamos National Laboratory industrial applications and technology transfer

    SciTech Connect

    Not Available

    1991-10-31

    This report summarizes the accomplishments of the Los Alamos Economic Development Corporation (LAEDC) under its contract with the Industrial Applications Office (IAO). The LAEDC has: provided business planning assistance to potential entrepreneurs, assisted IAO in preparing and distributing informational materials on technology, organized and managed meetings and seminars on technology transfer and entrepreneurship, identified new opportunities for technology transfer, and identified and implemented programs for the recognition of Laboratory entrepreneurs.

  18. Los Alamos Canyon Ice Rink Parking Flood Plain Assessment

    SciTech Connect

    Hathcock, Charles Dean

    2015-02-10

    The project location is in Los Alamos Canyon east of the ice rink facility at the intersection of West and Omega roads (Figure 1). Forty eight parking spaces will be constructed on the north and south side of Omega Road, and a lighted walking path will be constructed to the ice rink. Some trees will be removed during this action. A guardrail of approximately 400 feet will be constructed along the north side of West Road to prevent unsafe parking in that area.

  19. Inertial Confinement Fusion Research at LOS Alamos National Laboratory

    NASA Astrophysics Data System (ADS)

    Batha, S. H.; Albright, B. J.; Alexander, D. J.; Barnes, Cris W.; Bradley, P. A.; Cobble, J. A.; Cooley, J. C.; Cooley, J. H.; Day, R. D.; DeFriend, K. A.; Delamater, N. D.; Dodd, E. S.; Fatherley, V. E.; Fernandez, J. C.; Flippo, K. A.; Grim, G. P.; Goldman, S. R.; Greenfield, S. R.; Herrmann, H. W.; Hoffman, N. M.; Holmes, R. L.; Johnson, R. P.; Keiter, P. A.; Kline, J. L.; Kyrala, G. A.; Lanier, N. E.; Loomis, E.; Lopez, F. E.; Luo, S.; Mack, J. M.; Magelssen, G. R.; Montgomery, D. S.; Nobile, A.; Oertel, J. A.; Reardon, P.; Rose, H. A.; Schmidt, D.; Schmitt, M. J.; Seifter, A.; Shimada, T.; Swift, D. C.; Tierney, T. E.; Welser-Sherrill, L.; Wilke, M. D.; Wilson, D. C.; Workman, J.; Yin, L.

    2009-07-01

    Inertial confinement fusion research at Los Alamos National Laboratory is focused on high-leverage areas of thermonuclear ignition to which LANL can apply its historic strengths and that are complementary to high-energy-density-physics topics. Using the Trident and Omega laser facilities, experiments are pursued in laser-plasma instabilities, symmetry, Be technologies, neutron and fusion-product diagnostics, and defect hydrodynamics.

  20. Los Alamos sequence analysis package for nucleic acids and proteins.

    PubMed Central

    Kanehisa, M I

    1982-01-01

    An interactive system for computer analysis of nucleic acid and protein sequences has been developed for the Los Alamos DNA Sequence Database. It provides a convenient way to search or verify various sequence features, e.g., restriction enzyme sites, protein coding frames, and properties of coded proteins. Further, the comprehensive analysis package on a large-scale database can be used for comparative studies on sequence and structural homologies in order to find unnoted information stored in nucleic acid sequences. PMID:6174934

  1. Interseismic strain accumulation and anthropogenic motion in metropolitan Los Angeles

    NASA Astrophysics Data System (ADS)

    Argus, D. F.; Heflin, M. B.; Peltzer, G.; Crampe, F.; Webb, F. H.

    2005-05-01

    We use global positioning system (GPS) geodesy and synthetic aperture radar (SAR) interferometry to distinguish between interseismic strain accumulation and anthropogenic motion in metropolitan Los Angeles. We establish a relationship between horizontal and vertical seasonal oscillations of the Santa Ana aquifer, use this relationship to infer cumulative horizontal anthropogenic motions from cumulative vertical motions caused by water and oil resource management, and estimate horizontal interseismic velocities corrected for anthropogenic effects. Vertical anthropogenic rates from 1992 to 1999 are slower than 3 mm/yr in the Santa Ana and San Gabriel aquifers and faster than 5 mm/yr in the Chino aquifer and in many oil fields. Inferred horizontal anthropogenic velocities are faster than 1 mm/yr at 18 of 46 GPS sites. Northern metropolitan Los Angeles is contracting, with the 25 km south of the San Gabriel mountains shortening at 4.5 ±1 mm/yr (95% confidence limits). The thrust fault in an elastic edge dislocation model of the observed strain is creeping at 9 ±2 mm/yr beneath and north of a position 6 ±2 km deep and 8 ±8 km north of downtown Los Angeles. The model fault is near the Los Angeles segment of the Puente Hills thrust but south of the Sante Fe Springs segment of the thrust. Disagreement between the 6 km locking depth in the model and the 15 km seismogenic depth inferred from earthquakes suggests that the elastic continuum model may be unsatisfactory; models with different stiffnesses of sedimentary basin and crystalline basement must be investigated.

  2. Interseismic strain accumulation and anthropogenic motion in metropolitan Los Angeles

    NASA Astrophysics Data System (ADS)

    Argus, Donald F.; Heflin, Michael B.; Peltzer, Gilles; Crampé, FréDeric; Webb, Frank H.

    2005-04-01

    We use global positioning system (GPS) geodesy and synthetic aperture radar (SAR) interferometry to distinguish between interseismic strain accumulation and anthropogenic motion in metropolitan Los Angeles. We establish a relationship between horizontal and vertical seasonal oscillations of the Santa Ana aquifer, use this relationship to infer cumulative horizontal anthropogenic motions from cumulative vertical motions caused by water and oil resource management, and estimate horizontal interseismic velocities corrected for anthropogenic effects. Vertical anthropogenic rates from 1992 to 1999 are slower than 3 mm yr-1 in the Santa Ana and San Gabriel aquifers and faster than 5 mm yr-1 in the Chino aquifer and in many oil fields. Inferred horizontal anthropogenic velocities are faster than 1 mm yr-1 at 18 of 46 GPS sites. Northern metropolitan Los Angeles is contracting, with the 25 km south of the San Gabriel Mountains shortening at 4.5 ± 1 mm yr-1 (95% confidence limits). The thrust fault in an elastic edge dislocation model of the observed strain is creeping at 9 ± 2 mm yr-1 beneath and north of a position 6 ± 2 km deep and 8 ± 8 km north of downtown Los Angeles. The model fault is near the Los Angeles segment of the Puente Hills thrust but south of the Sante Fe Springs segment of the thrust. Disagreement between the 6 km locking depth in the model and the 15 km seismogenic depth inferred from earthquakes suggests that the elastic continuum model may be unsatisfactory; models with different stiffnesses of sedimentary basin and crystalline basement must be investigated.

  3. El Proyecto Sismico "LARSE" - Trabajando Hacia un Futuro con Mas Seguridad para Los Angeles

    USGS Publications Warehouse

    Henyey, Thomas L.; Fuis, Gary S.; Benthien, Mark L.; Burdette, Thomas R.; Christofferson, Shari A.; Clayton, Robert W.; Criley, Edward E.; Davis, Paul M.; Hendley, James W.; Kohler, Monica D.; Lutter, William J.; McRaney, John K.; Murphy, Janice M.; Okaya, David A.; Ryberg, Trond; Simila, Gerald W.; Stauffer, Peter H.

    1999-01-01

    La region de Los Angeles contiene una red de fallas activas, incluyendo muchas fallas por empuje que son profundas y no rompen la superficie de la tierra. Estas fallas ocultas incluyen la falla anteriormente desconocida que fue responsable por la devastacion que ocurrio durante el terremoto de Northridge en enero de 1994, el terremoto mas costoso en la historia de los Estados Unidos. El Experimento Sismico en la Region de Los Angeles (Los Angeles Region Seismic Experiment, LARSE), esta localizando los peligros ocultos de los terremotos debajo de la region de Los Angeles para mejorar la construccion de las estructuras que pueden apoyar terremotos que son inevitables en el futuro, y que ayudaran a los cientificos determinar donde occurira el sacudimento mas fuerte y poderoso.

  4. Overview of laser technology at Los Alamos National Laboratory

    NASA Astrophysics Data System (ADS)

    Lewis, G. K.; Cremers, D. A.

    Los Alamos National Laboratory has had a long history of involvement in laser sciences and has been recognized both for its large laser programs and smaller scale developments in laser technology and applications. The first significant program was with the Rover nuclear-based rocket propulsion system in 1968 to study laser initiated fusion. From here applications spread to programs in laser isotope separation and development of large lasers for fusion. These programs established the technological human resource base of highly trained laser physicists, engineers, and chemists that remain at the Laboratory today. Almost every technical division at Los Alamos now has some laser capability ranging from laser development, applications, studies on nonlinear processes, modeling and materials processing. During the past six years over eight R&D-100 Awards have been received by Los Alamos for development of laser-based techniques and instrumentation. Outstanding examples of technology developed include LIDAR applications to environmental monitoring, single molecule detection using fluorescence spectroscopy, a laser-based high kinetic energy source of oxygen atoms produced by a laser-sustained plasma, laser-induced breakdown spectroscopy (LIBS) for compositional, analysis, thin film high temperature superconductor deposition, multi-station laser welding, and direct metal deposition and build-up of components by fusing powder particles with a laser beam.

  5. Los Alamos, Toshiba probing Fukushima with cosmic rays

    SciTech Connect

    Morris, Christopher

    2014-06-16

    Los Alamos National Laboratory has announced an impending partnership with Toshiba Corporation to use a Los Alamos technique called muon tomography to safely peer inside the cores of the Fukushima Daiichi reactors and create high-resolution images of the damaged nuclear material inside without ever breaching the cores themselves. The initiative could reduce the time required to clean up the disabled complex by at least a decade and greatly reduce radiation exposure to personnel working at the plant. Muon radiography (also called cosmic-ray radiography) uses secondary particles generated when cosmic rays collide with upper regions of Earth's atmosphere to create images of the objects that the particles, called muons, penetrate. The process is analogous to an X-ray image, except muons are produced naturally and do not damage the materials they contact. Muon radiography has been used before in imaginative applications such as mapping the interior of the Great Pyramid at Giza, but Los Alamos's muon tomography technique represents a vast improvement over earlier technology.

  6. Paleoenvironmental and paleoclimatic investigations on Isla de los Estados, Argentina

    NASA Astrophysics Data System (ADS)

    Björck, S.; Fernandez, M.; Hjort, C.; Ljung, K.; Martinez, O.; Möller, P.; Ponce, F.; Rabassa, J.; Roig, F.; Unkel, I.; Wohlfarth, B.

    2007-05-01

    The expedition in November-December 2005 to Isla de los Estados (Staten Island) off the southeastern tip of South America was a cooperative venture between Lund University (LU) and Stockholm University (SU) in Sweden and the CADIC-CONICET Institute in Ushuaia, Argentina. The aim of the expedition was threefold: (1) to extend the Swedish paleoclimatic "ATLANTIS"-project (Greenland, Iceland, Faroe Islands, Azores, Grenada, Tristan da Cunha; PI S Björck) to the southern part of the South American continent, (2) to connect earlier glacial and climate history reconstructions from the Antarctic Peninsula to equivalents north of the Drake Passage in southernmost South America, and (3) to complement paleo-information available from the Tierra del Fuego mainland with information from Isla de los Estados. Focus was on two areas in the northern and north-western part of the island, Bahía Colnett and Bahia Crossley. Detailed geomorphologic and stratigraphic mapping of glacial deposits were combined with sampling sediments for OSL dating. To reconstruct the paleoclimatic development of Isla de los Estados since the last ice retreat, four main peat bog/lake sites were cored and sampled. In addition, living trees of Nothofagus and old logs preserved in the peat were sampled for dendrochronological and dendroclimatological studies. Preliminary results show that the deglaciation of the study area occurred before 16500 cal yr BP. Detailed multi- proxy analyses of the four sequences are under way and first results will be presented.

  7. Los Alamos Science: The Human Genome Project. Number 20, 1992

    DOE R&D Accomplishments Database

    Cooper, N. G.; Shea, N. eds.

    1992-01-01

    This document provides a broad overview of the Human Genome Project, with particular emphasis on work being done at Los Alamos. It tries to emphasize the scientific aspects of the project, compared to the more speculative information presented in the popular press. There is a brief introduction to modern genetics, including a review of classic work. There is a broad overview of the Genome Project, describing what the project is, what are some of its major five-year goals, what are major technological challenges ahead of the project, and what can the field of biology, as well as society expect to see as benefits from this project. Specific results on the efforts directed at mapping chromosomes 16 and 5 are discussed. A brief introduction to DNA libraries is presented, bearing in mind that Los Alamos has housed such libraries for many years prior to the Genome Project. Information on efforts to do applied computational work related to the project are discussed, as well as experimental efforts to do rapid DNA sequencing by means of single-molecule detection using applied spectroscopic methods. The article introduces the Los Alamos staff which are working on the Genome Project, and concludes with brief discussions on ethical, legal, and social implications of this work; a brief glimpse of genetics as it may be practiced in the next century; and a glossary of relevant terms.

  8. Los Angeles asks court to rehear religious rights case.

    PubMed

    1999-04-02

    A three-judge panel of the U.S. Circuit Court of Appeals has been asked to rehear an Alaskan case joined by the City of Los Angeles allowing landlords to discriminate on the basis of marital status. Such a decision has implications for gay and lesbian couples and potentially for people living with HIV. The original lawsuit by two landlords, [name removed] and [name removed], argued that facilitating cohabitation between unmarried persons is tantamount to facilitating sin which is against their religious principles. The court ruled that Alaska's fair-housing law violated the landlords' right to exercise their religion, their First Amendment right to free speech, and their Fifth Amendment rights against taking private property for public purposes unlawfully. In seeking a rehearing, the Los Angeles City attorney states that for landlords to exercise the "religious belief" exception to the statute, they would have to ask penetrating questions about potential tenants, including questions on their sexual orientation and HIV status. The brief submitted to the court notes that people with HIV in Los Angeles have an urgent need for apartments.

  9. Los Alamos Science: The Human Genome Project. Number 20, 1992

    SciTech Connect

    Cooper, N G; Shea, N

    1992-01-01

    This article provides a broad overview of the Human Genome Project, with particular emphasis on work being done at Los Alamos. It tries to emphasize the scientific aspects of the project, compared to the more speculative information presented in the popular press. There is a brief introduction to modern genetics, including a review of classic work. There is a broad overview of the Genome Project, describing what the project is, what are some of its major five-year goals, what are major technological challenges ahead of the project, and what can the field of biology, as well as society expect to see as benefits from this project. Specific results on the efforts directed at mapping chromosomes 16 and 5 are discussed. A brief introduction to DNA libraries is presented, bearing in mind that Los Alamos has housed such libraries for many years prior to the Genome Project. Information on efforts to do applied computational work related to the project are discussed, as well as experimental efforts to do rapid DNA sequencing by means of single-molecule detection using applied spectroscopic methods. The article introduces the Los Alamos staff which are working on the Genome Project, and concludes with brief discussions on ethical, legal, and social implications of this work; a brief glimpse of genetics as it may be practiced in the next century; and a glossary of relevant terms.

  10. Los Alamos, Toshiba probing Fukushima with cosmic rays

    ScienceCinema

    Morris, Christopher

    2016-07-12

    Los Alamos National Laboratory has announced an impending partnership with Toshiba Corporation to use a Los Alamos technique called muon tomography to safely peer inside the cores of the Fukushima Daiichi reactors and create high-resolution images of the damaged nuclear material inside without ever breaching the cores themselves. The initiative could reduce the time required to clean up the disabled complex by at least a decade and greatly reduce radiation exposure to personnel working at the plant. Muon radiography (also called cosmic-ray radiography) uses secondary particles generated when cosmic rays collide with upper regions of Earth's atmosphere to create images of the objects that the particles, called muons, penetrate. The process is analogous to an X-ray image, except muons are produced naturally and do not damage the materials they contact. Muon radiography has been used before in imaginative applications such as mapping the interior of the Great Pyramid at Giza, but Los Alamos's muon tomography technique represents a vast improvement over earlier technology.

  11. Overview of laser technology at Los Alamos National Laboratory

    SciTech Connect

    Lewis, G.K.; Cremers, D.A.

    1994-09-01

    Los Alamos National Laboratory has had a long history of involvement in laser sciences and has been recognized both for its large laser programs and smaller scale developments in laser technology and applications. The first significant program was with the Rover nuclear-based rocket propulsion system in 1968 to study laser initiated fusion. From here applications spread to programs in laser isotope separation and development of large lasers for fusion. These programs established the technological human resource base of highly trained laser physicists, engineers, and chemists that remain at the Laboratory today. Almost every technical division at Los Alamos now has some laser capability ranging from laser development, applications, studies on nonlinear processes, modeling and materials processing. During the past six years over eight R&D-100 Awards have been received by Los Alamos for development of laser-based techniques and instrumentation. Outstanding examples of technology developed include LIDAR applications to environmental monitoring, single molecule detection using fluorescence spectroscopy, a laser-based high kinetic energy source of oxygen atoms produced by a laser-sustained plasma, laser-induced breakdown spectroscopy (LIBS) for compositional, analysis, thin film high temperature superconductor deposition, multi-station laser welding, and direct metal deposition and build-up of components by fusing powder particles with a laser beam.

  12. Water supply at Los Alamos during 1996. Progress report

    SciTech Connect

    McLin, S.G.; Purtymun, W.D.; Maes, M.N.; Longmire, P.A.

    1997-12-01

    Production of potable municipal water supplies during 1996 totaled about 1,368.1 million gallons from wells in the Guaje, Pajarito, and Otowi well fields. There was no water used from either the spring gallery in Water Canyon or from Guaje Reservoir during 1996. About 2.6 million gallons of water from Los Alamos Reservoir was used for lawn irrigation. The total water usage in 1996 was about 1,370.7 million gallons, or about 131 gallons per day per person living in Los Alamos County. Groundwater pumpage was up about 12.0 million gallons in 1996 compared with the pumpage in 1995. This report fulfills requirements specified in US Department of Energy (DOE) Order 5400.1 (Groundwater Protection Management Program), which requires the Los Alamos National Laboratory (LANL) to monitor and document groundwater conditions below Pajarito Plateau and to protect the regional aquifer from contamination associated with Laboratory operations. Furthermore, this report also fulfills special conditions by providing information on hydrologic characteristics of the regional aquifer, including operating conditions of the municipal water supply system.

  13. The seismic response of the Los Angeles basin, California

    USGS Publications Warehouse

    Wald, D.J.; Graves, R.W.

    1998-01-01

    Using strong-motion data recorded in the Los Angeles region from the 1992 (Mw 7.3) Landers earthquake, we have tested the accuracy of existing three-dimensional (3D) velocity models on the simulation of long-period (???2 sec) ground motions in the Los Angeles basin and surrounding San Fernando and San Gabriel Valleys. First, the overall pattern and degree of long-period excitation of the basins were identified in the observations. Within the Los Angeles basin, the recorded amplitudes are about three to four times larger than at sites outside the basins; amplitudes within the San Fernando and San Gabriel Valleys are nearly a factor of 3 greater than surrounding bedrock sites. Then, using a 3D finite-difference numerical modeling approach, we analyzed how variations in 3D earth structure affect simulated waveforms, amplitudes, and the fit to the observed patterns of amplification. Significant differences exist in the 3D velocity models of southern California that we tested (Magistrale et al., 1996; Graves, 1996a; Hauksson and Haase, 1997). Major differences in the models include the velocity of the assumed background models; the depth of the Los Angeles basin; and the depth, location, and geometry of smaller basins. The largest disparities in the response of the models are seen for the San Fernando Valley and the deepest portion of the Los Angeles basin. These arise in large part from variations in the structure of the basins, particularly the effective depth extent, which is mainly due to alternative assumptions about the nature of the basin sediment fill. The general ground-motion characteristics are matched by the 3D model simulations, validating the use of 3D modeling with geologically based velocity-structure models. However, significant shortcomings exist in the overall patterns of amplification and the duration of the long-period response. The successes and limitations of the models for reproducing the recorded ground motions as discussed provide the basis and

  14. A Reappraising of Cosmography: the Interface Between Astronomical and Geographic Studies. (Breton Title: Releitura do Conceito de Cosmografia: a Interface Entre os Estudos Astronômicos e Geográficos.) Una Relectura del Concepto de Cosmografía: la Interfase Entre los Estudios Astronómicos y Geográficos

    NASA Astrophysics Data System (ADS)

    Azevedo Sobreira, Paulo Henrique

    2012-12-01

    The concept of "Cosmography" is in disuse since the 80s of the last century, but the astronomical themes previously discussed in the school subjects of Geography and Cosmography remain in current textbooks. The use of term "Cosmography" was rescued in this research, and the study of its re-signification prompted the appearance of the term Geographic Cosmography. The Geographic Cosmography is a field of studies of the Geography, whose set of knowledge and skills is predominantly scholar. It studies the interface between terrestrial and celestial knowledge, and assigns a geographic significance to them. It examines human and natural relationships with Sidereal Space and its consequences for society and nature. O conceito de "Cosmografia" está em desuso desde os anos 80 do século XX, mas os temas astronômicos anteriormente abordados nas disciplinas escolares de Cosmografia e de Geografia permanecem nos atuais livros didáticos. O uso do termo "Cosmografia" foi resgatado nesta pesquisa e o estudo de sua ressignificação proporcionou o surgimento do termo Cosmografia Geográfica. A Cosmografia Geográfica é um campo de estudos da Geografia, cujo conjunto de conhecimentos e habilidades é predominantemente escolar. Estuda a interface entre os conhecimentos terrestres e os celestes e lhes atribui significância geográfica. Analisa as relações humanas e naturais com o Espaço Sideral e suas consequências para a sociedade e a natureza.

    Aunque el concepto de "Cosmografía" no se usa desde la década de los '80 del siglo pasado, los temas astronómicos que se enseñaban anteriormente en las asignaturas escolares de Cosmografía y de Geografía permanecen en los actuales libros didácticos. El uso del término "Cosmografía" fue rescatado en esta investigación y el estudio de su resignificación proporcionó el surgimiento del término Cosmografía Geográfica. La Cosmografía Geográfica es un campo de estudio de la Geografía, donde

  15. 75 FR 71455 - The Jewelry Stream, Los Angeles, CA; Notice of Affirmation Determination Regarding Application...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-23

    ... Employment and Training Administration The Jewelry Stream, Los Angeles, CA; Notice of Affirmation... investigation applicable to workers and former workers of M&L Manufacturing, Inc. and The Jewelry Stream, Los... Assistance (TAA) petition--M&L Manufacturing, Inc. and The Jewelry Stream, Los Angeles, California--is...

  16. 76 FR 35946 - BNSF Railway Company-Abandonment Exemption-in Los Angeles County, CA.

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-20

    .... 477X] BNSF Railway Company--Abandonment Exemption--in Los Angeles County, CA. On May 31, 2011, BNSF... over 4.85 miles of rail line owned by Los Angeles County Metropolitan Transportation Authority (LACMTA..., just east of the Santa Anita Blvd. grade crossing, in Arcadia, in Los Angeles County, CA (the...

  17. 40 CFR 81.17 - Metropolitan Los Angeles Air Quality Control Region.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Quality Control Regions § 81.17 Metropolitan Los Angeles Air Quality Control Region. The Metropolitan Los Angeles Air Quality Control Region consists of the following territorial area (including the territorial... 40 Protection of Environment 18 2014-07-01 2014-07-01 false Metropolitan Los Angeles Air...

  18. 40 CFR 81.17 - Metropolitan Los Angeles Air Quality Control Region.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Quality Control Regions § 81.17 Metropolitan Los Angeles Air Quality Control Region. The Metropolitan Los Angeles Air Quality Control Region consists of the following territorial area (including the territorial... 40 Protection of Environment 18 2012-07-01 2012-07-01 false Metropolitan Los Angeles Air...

  19. 40 CFR 81.17 - Metropolitan Los Angeles Air Quality Control Region.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Quality Control Regions § 81.17 Metropolitan Los Angeles Air Quality Control Region. The Metropolitan Los Angeles Air Quality Control Region consists of the following territorial area (including the territorial... 40 Protection of Environment 18 2013-07-01 2013-07-01 false Metropolitan Los Angeles Air...

  20. Los Angeles - Long Beach Harbors, California. Los Angeles Harbor Deepening Project. Final Phase 2. General Design Memorandum.

    DTIC Science & Technology

    1980-01-01

    O .. STOW SIZE S A DESIGN O EIGNTS U S. Ap.0y 00 ’ FRPLATECCXOOSANGENE [II ’~~LOS ANGELES5...in 1970, designate the Reeves Field Harbor area as "open" on their harbor model plan with the understanding that it would be used for recreational...dictated by peak electrical demand . PART III: THE PHYSICAL MODEL Description 18. The physical hydraulic model reproducEs San Pedro Bay and a portion of

  1. Audit Report, "Fire Protection Deficiencies at Los Alamos National Laboratory"

    SciTech Connect

    2009-06-01

    The Department of Energy's Los Alamos National Laboratory (Los Alamos) maintains some of the Nation's most important national security assets, including nuclear materials. Many of Los Alamos' facilities are located in close proximity to one another, are occupied by large numbers of contract and Federal employees, and support activities ranging from nuclear weapons design to science-related activities. Safeguarding against fires, regardless of origin, is essential to protecting employees, surrounding communities, and national security assets. On June 1, 2006, Los Alamos National Security, LLC (LANS), became the managing and operating contractor for Los Alamos, under contract with the Department's National Nuclear Security Administration (NNSA). In preparation for assuming its management responsibilities at Los Alamos, LANS conducted walk-downs of the Laboratory's facilities to identify pre-existing deficiencies that could give rise to liability, obligation, loss or damage. The walk-downs, which identified 812 pre-existing fire protection deficiencies, were conducted by subject matter professionals, including fire protection experts. While the Los Alamos Site Office has overall responsibility for the effectiveness of the fire protection program, LANS, as the Laboratory's operating contractor, has a major, day-to-day role in minimizing fire-related risks. The issue of fire protection at Los Alamos is more than theoretical. In May 2000, the 'Cerro Grande' fire burned about 43,000 acres, including 7,700 acres of Laboratory property. Due to the risk posed by fire to the Laboratory's facilities, workforce, and surrounding communities, we initiated this audit to determine whether pre-existing fire protection deficiencies had been addressed. Our review disclosed that LANS had not resolved many of the fire protection deficiencies that had been identified in early 2006: (1) Of the 296 pre-existing deficiencies we selected for audit, 174 (59 percent) had not been corrected

  2. Commercialization of Los Alamos National Laboratory technologies via small businesses. Final report

    SciTech Connect

    Brice, R.; Carton, D.; Rhyne, T.

    1997-06-01

    Appendices are presented from a study performed on a concept model system for the commercialization of Los Alamos National Laboratory technologies via small businesses. Topics include a summary of information from the joint MCC/Los Alamos technology conference; a comparison of New Mexico infrastructure to other areas; a typical licensing agreement; technology screening guides; summaries of specific DOE/UC/Los Alamos documents; a bibliography; the Oak Ridge National Laboratory TCRD; The Ames Center for Advanced Technology Development; Los Alamos licensing procedures; presentation of slides from monthly MCC/Los Alamos review meetings; generalized entrepreneurship model; and a discussion on receiving equity for technology.

  3. Interseismic Strain Accumulation Across Metropolitan Los Angeles: Puente Hills Thrust

    NASA Astrophysics Data System (ADS)

    Argus, D.; Liu, Z.; Heflin, M. B.; Moore, A. W.; Owen, S. E.; Lundgren, P.; Drake, V. G.; Rodriguez, I. I.

    2012-12-01

    Twelve years of observation of the Southern California Integrated GPS Network (SCIGN) are tightly constraining the distribution of shortening across metropolitan Los Angeles, providing information on strain accumulation across blind thrust faults. Synthetic Aperture Radar Interferometry (InSAR) and water well records are allowing the effects of water and oil management to be distinguished. The Mojave segment of the San Andreas fault is at a 25° angle to Pacific-North America plate motion. GPS shows that NNE-SSW shortening due to this big restraining bend is fastest not immediately south of the San Andreas fault across the San Gabriel mountains, but rather 50 km south of the fault in northern metropolitan Los Angeles. The GPS results we quote next are for a NNE profile through downtown Los Angeles. Just 2 mm/yr of shortening is being taken up across the San Gabriel mountains, 40 km wide (0.05 micro strain/yr); 4 mm/yr of shortening is being taken up between the Sierra Madre fault, at the southern front of the San Gabriel mountains, and South Central Los Angeles, also 40 km wide (0.10 micro strain/yr). We find shortening to be more evenly distributed across metropolitan Los Angeles than we found before [Argus et al. 2005], though within the 95% confidence limits. An elastic models of interseismic strain accumulation is fit to the GPS observations using the Back Slip model of Savage [1983]. Rheology differences between crystalline basement and sedimentary basin rocks are incorporated using the EDGRN/EDCMP algorithm of Wang et al. [2003]. We attempt to place the Back Slip model into the context of the Elastic Subducting Plate Model of Kanda and Simons [2010]. We find, along the NNE profile through downtown, that: (1) The deep Sierra Madre Thrust cannot be slipping faster than 2 mm/yr, and (2) The Puente Hills Thrust and nearby thrust faults (such as the upper Elysian Park Thrust) are slipping at 9 ±2 mm/yr beneath a locking depth of 12 ±5 km (95% confidence limits

  4. Reconnaissance of geothermal resources of Los Angeles County, California

    SciTech Connect

    Higgins, C.T.

    1981-01-01

    Thermal waters produced from large oil fields are currently the most important geothermal resources in Los Angeles County. Otherwise, the County does not appear to have any large, near-surface geothermal resources. The oil fields produce thermal water because of both the moderate depths of production and normal to above-normal geothermal gradients. Gradients are about 3.0-3.5/sup 0/C/100 meters in the Ventura Basin and range from that up to about 5.5-6.0/sup 0/C/100 meters in the Los Angeles Basin. The hottest fields in the County are west of the Newport-Inglewood Structural Zone. The Los Angeles Basin has substantially more potential for uses of heat from oil fields than does the Ventura Basin because of its large fields and dense urban development. Produced fluid temperatures there range from ambient air to boiling, but most are in the 100-150/sup 0/F range. Daily water production ranges from only a few barrels at some fields to over a million barrels at Wilmington Oil Field; nearly all fields produce less than 50,000 barrels/day. Water salinity generally ranges from about 15,000-35,000 mg/liter NaCl. Fields with the most promise as sources of heat for outside applications are Wilmington, Torrance, Venice Beach, and Lawndale. The centralized treatment facilities are the most favorable sites for extraction of heat within the oil fields. Because of the poor water quality heat exchangers will likely be required rather than direct circulation of the field water to users. The best sites for applications are commercial-industrial areas and possibly institutional structures occupied by large numbers of people.

  5. Characteristic roofing slates from Spain: Mormeau and Los Molinos

    NASA Astrophysics Data System (ADS)

    Cardenes Van den Eynde, Victor; Cnudde, Veerle; Cnudde, Jean Pierre

    2014-05-01

    Characteristic roofing slates from Spain: Mormeau and Los Molinos Cardenes1, V., Cnudde1, V., Cnudde1, J.P. 1 Department of Geology and Soil Science, Ghent University, Krijgslaan 281, S8, 9000 Ghent, Belgium. The world's major roofing slate outcrops are found in the NW of Spain, in the Ordovician terrains of the domain of the Truchas Syncline. In this remote area, slate was quarried since ancient times for the use of the inhabitants of the region. Half of a century ago, an industrialization process took place in this area, which began to produce high quality roofing slate for many buildings from Japan to the USA, and especially in Europe. Since then, Spanish slate roofing has been widely used for new buildings and also for restoration of historical buildings. This work revises the occurrence and characteristics of the two most representative grey slate varieties from the Truchas Syncline, Mormeau, a fine-grained slate, and Los Molinos, also a grey slate with a slightly coarser grain. Both slates have a very similar aspect, but Mormeau slate have some iron sulphides on its composition that sometimes forms oxidation spots. Mormeau beds are found at the Middle-Upper Ordovician age Casaio Formation, while Los Molinos beds are located at the Rozadais Formation, of age Upper Ordovician, defined as formation just for the Truchas Syncline domain. Both slates have a high degree of homogeneity on their constructive characteristics, with a typical composition of quartz, mica and chlorites, and a metamorphic degree corresponding to the green schists facies. This work revises the history and characteristics of both slates, that can be considered as lithotypes that can be used as a reference during the prospection of new slate outcrops worldwide. The presented varieties of slate are proposed for their inclusion as Global Heritage Stones.

  6. Observaciones CCD de los cúmulos abiertos Melotte 105, Ruprecht~75 y Pismis 7

    NASA Astrophysics Data System (ADS)

    Ahumada, J.; Lapasset, E.

    Se presentan los resultados preliminares de observaciones CCD en cinco colores (UBVRI) de campos de ~2,5' de radio centrados en los cúmulos abiertos Melotte 105, Ruprecht 75 y Pismis 7. Los datos fueron adquiridos en abril de 1996 con el telescopio de 60 cm de la Universidad de Toronto en Las Campanas (Chile), y el detector PM512 en su modo directo. Se muestran los diagramas color-magnitud y color-color preliminares de los cúmulos. Mediante criterios fotométricos se hace una selección de los posibles miembros. También se determinan enrojecimientos, distancias y edades de los cúmulos.

  7. C1-C14 carbonyls in Los Angeles air

    SciTech Connect

    Grosjean, E.; Grosjean, D.; Fraser, M.; Cass, G.R.

    1995-12-01

    Air samples collected at five Los Angeles locations have been analyzed for carbonyls as their DNPH derivatives using liquid chromatography and chemical ionization mass spectrometry. Twenty-three carbonyls have been measured: 14 aliphatic aldehydes (from formaldehyde to tetradecanal); 2 aromatics (benzaldehyde and m-tolualdehyde), 3 ketones (acetone, 2-butanone and cyclohexanone), one unsaturated carbonyl (crotonaldehyde) and 3 dicarbonyls (glyoxal, methylglyoxal and biacetyl). Another nineteen carbonyls have been tentatively identified including four high MW (C{sub 15}-C{sub 18}) aliphatic carbonyls.

  8. Groundwater level status report for 2009, Los Alamos National Laboratory

    SciTech Connect

    Koch, Richard J.; Schmeer, Sarah

    2010-03-01

    The status of groundwater level monitoring at Los Alamos National Laboratory in 2009 is provided in this report. This report summarizes groundwater level data for 179 monitoring wells, including 55 regional aquifer wells (including 11 regional/intermediate wells), 26 intermediate wells, 98 alluvial wells, and 12 water supply wells. Pressure transducers were installed in 161 monitoring wells for continuous monitoring of groundwater levels. Time-series hydrographs of groundwater level data are presented along with pertinent construction and location information for each well. The report also summarizes the groundwater temperatures recorded in intermediate and regional aquifer monitoring wells.

  9. Los Alamos National Laboratory Economic Analysis Capability Overview

    SciTech Connect

    Boero, Riccardo; Edwards, Brian Keith; Pasqualini, Donatella; Rivera, Michael Kelly

    2016-04-19

    Los Alamos National Laboratory has developed two types of models to compute the economic impact of infrastructure disruptions. FastEcon is a fast running model that estimates first-­order economic impacts of large scale events such as hurricanes and floods and can be used to identify the amount of economic activity that occurs in a specific area. LANL’s Computable General Equilibrium (CGE) model estimates more comprehensive static and dynamic economic impacts of a broader array of events and captures the interactions between sectors and industries when estimating economic impacts.

  10. Wood and fruit drying in Los Azufres geothermal field, Mexico

    SciTech Connect

    Casimiro, E.; Pastrana, E.

    1996-12-31

    The main object of Comision Federal de Electricidad (CFE`s) Geothermal Field at Los Azufres, is to generate geothermal electricity; however with the new politics in Mexico CFE has built a pilot project in order to profit from the geothermal residual energy and to attract national or foreign investors and convince them that direct-use of geothermal energy is an attractive feasible and economical possibility. The object of this paper is to present the CFE experiences in wood and fruit drying using geothermal energy.

  11. Geochemical model update of the Los Azufres, Mexico, geothermal reservoir

    SciTech Connect

    Hinojosa, E.T.

    1997-12-31

    Chemical and isotopic analyses of fluids produced by wells the Los Azuftes, Michoacan, geothermal field, have been studied to establish a geochemical model of the field. Water produced by the wells has a sodium-chloride composition characteristic of geothermal brine. This to be in equilibrium with the host rock at temperatures which vary from 280{degrees}C to 340{degrees}C. Based on steam data, the wells are producing from a liquid dominanted zone. The isotopic composition of the wells presents a shift with respect to meteoric line of {delta}{sup 18}O typical to fluids of geothermal origin which have equilibrated with rock at high temperatures.

  12. Bradbury science museum: your window to Los Alamos National Laboratory

    SciTech Connect

    Deck, Linda Theresa

    2009-03-05

    The Bradbury Science Museum is the public's window to Los Alamos National Laboratory and supports the Community Program Office's mission to develop community support to accomplish LANL's national security and science mission. It does this by stimulating interest in and increasing basic knowledge of science and technology in northern New Mexico audiences, and increasing public understanding and appreciation of how LANL science and technology solve our global problems. In performing these prime functions, the Museum also preserves the history of scientific accomplishment at the Lab by collecting and preserving artifacts of scientific and historical importance.

  13. Groundwater level status report for 2010, Los Alamos National Laboratory

    SciTech Connect

    Koch, Richard J.; Schmeer, Sarah

    2011-03-01

    The status of groundwater level monitoring at Los Alamos National Laboratory in 2010 is provided in this report. This report summarizes groundwater level data for 194 monitoring wells, including 63 regional aquifer wells (including 10 regional/intermediate wells), 34 intermediate wells, 97 alluvial wells, and 12 water supply wells. Pressure transducers were installed in 162 monitoring wells for continuous monitoring of groundwater levels. Time-series hydrographs of groundwater level data are presented along with pertinent construction and location information for each well. The report also summarizes the groundwater temperatures recorded in intermediate and regional aquifer monitoring wells and seasonal responses to snowmelt runoff observed in intermediate wells.

  14. Tiger Team Assessment of the Los Alamos National Laboratory

    SciTech Connect

    Not Available

    1991-11-01

    The purpose of the safety and health assessment was to determine the effectiveness of representative safety and health programs at the Los Alamos National Laboratory (LANL). Within the safety and health programs at LANL, performance was assessed in the following technical areas: Organization and Administration, Quality Verification, Operations, Maintenance, Training and Certification, Auxiliary Systems, Emergency Preparedness, Technical Support, Packaging and Transportation, Nuclear Criticality Safety, Security/Safety Interface, Experimental Activities, Site/Facility Safety Review, Radiological Protection, Personnel Protection, Worker Safety and Health (OSHA) Compliance, Fire Protection, Aviation Safety, Explosives Safety, Natural Phenomena, and Medical Services.

  15. Asymmetric Collapse of LOS Pipe-LS-4.

    DTIC Science & Technology

    1982-03-01

    and 2). It was demonstrated in previous tests that a thick internal helical spiral placed at the far end of a standard LOS pipe appeared to be equally...steel helix would also be effective. In two of the models (8 and 9), standard helices were placed inside the pipe for only the last 384 rmm of the... helices in attenuating jets, Models 10 and 11 contained standard rings in the last 355 mmn of pipe length. 2.3.11 Flow Region Asymmetries Contained in

  16. Recent developments in the Los Alamos radiation transport code system

    SciTech Connect

    Forster, R.A.; Parsons, K.

    1997-06-01

    A brief progress report on updates to the Los Alamos Radiation Transport Code System (LARTCS) for solving criticality and fixed-source problems is provided. LARTCS integrates the Diffusion Accelerated Neutral Transport (DANT) discrete ordinates codes with the Monte Carlo N-Particle (MCNP) code. The LARCTS code is being developed with a graphical user interface for problem setup and analysis. Progress in the DANT system for criticality applications include a two-dimensional module which can be linked to a mesh-generation code and a faster iteration scheme. Updates to MCNP Version 4A allow statistical checks of calculated Monte Carlo results.

  17. Groundwater level status report for 2008, Los Alamos National Laboratory

    SciTech Connect

    Koch, Richard J.; Schmeer, Sarah

    2009-03-01

    The status of groundwater level monitoring at Los Alamos National Laboratory in 2008 is provided in this report. This report summarizes groundwater level data for 179 monitoring wells, including 45 regional aquifer wells, 28 intermediate wells, 8 regional/intermediate wells, 106 alluvial wells, and 12 water supply wells. Pressure transducers were installed in 166 monitoring wells for continuous monitoring of groundwater levels. Time-series hydrographs of groundwater level data are presented along with pertinent construction and location information for each well. The report also summarizes the groundwater temperatures recorded in intermediate and regional aquifer monitoring wells.

  18. Groundwater Level Status Report for 2005 Los Alamos National Laboratory

    SciTech Connect

    S.P. Allen; R.J. Koch

    2006-05-15

    The status of groundwater level monitoring at Los Alamos National Laboratory (LANL) in 2005 is provided in this report. The Groundwater Level Monitoring Project was instituted in 2005 to provide a framework for the collection and processing of quality controlled groundwater level data. This report summarizes groundwater level data for 137 monitoring wells, including 41 regional aquifer wells, 22 intermediate wells, and 74 alluvial wells. Pressure transducers were installed in 118 monitoring wells for continuous monitoring of groundwater levels. Time-series hydrographs of groundwater level data are presented along with pertinent construction and location information for each well.

  19. The Los Alamos National Laboratory Nuclear Vision Project

    SciTech Connect

    Arthur, E.D.; Wagner, R.L. Jr.

    1996-09-01

    Los Alamos National Laboratory has initiated a project to examine possible futures associated with the global nuclear enterprise over the course of the next 50 years. All major components are included in this study--weapons, nonproliferation, nuclear power, nuclear materials, and institutional and public factors. To examine key issues, the project has been organized around three main activity areas--workshops, research and analyses, and development of linkages with other synergistic world efforts. This paper describes the effort--its current and planned activities--as well as provides discussion of project perspectives on nuclear weapons, nonproliferation, nuclear energy, and nuclear materials focus areas.

  20. Los Alamos Science, Number 25 -- 1997: Celebrating the Neutrino

    DOE R&D Accomplishments Database

    Cooper, N. G. ed.

    1997-01-01

    This issue is devoted to the neutrino and its remaining mysteries. It is divided into the following areas: (1) The Reines-Cowan experiment -- detecting the poltergeist; (2) The oscillating neutrino -- an introduction to neutrino masses and mixing; (3) A brief history of neutrino experiments at LAMPF; (4) A thousand eyes -- the story of LSND (Los Alamos neutrino oscillation experiment); (5) The evidence for oscillations; (6) The nature of neutrinos in muon decay and physics beyond the Standard Model; (7) Exorcising ghosts -- in pursuit of the missing solar neutrinos; (8) MSW -- a possible solution to the solar neutrino problem; (8) Neutrinos and supernovae; and (9) Dark matter and massive neutrinos.

  1. Mac configuration management at the Los Alamos National Laboratory

    SciTech Connect

    Marcus, Allan B

    2010-01-01

    The Los Alamos National Laboratory (LANL) had a need for central configuration management of non-Windows computers. LANL has three to five thousand Macs and an equal number of Linux based systems. The primary goal was to be able to inventory all non-windows systems and patch Mc OS X systems. LANL examined a number of commercial and open source solutions and ultimately selected Puppet. This paper will discuss why we chose Puppet, how we implemented it, and some lessons we learned along the way.

  2. Los Angeles, California, Radar Image, Wrapped Color as Height

    NASA Technical Reports Server (NTRS)

    2000-01-01

    This topographic radar image shows the relationships of the dense urban development of Los Angeles and the natural contours of the land. The image includes the Pacific Ocean on the left, the flat Los Angeles Basin across the center, and the steep ranges of the Santa Monica and Verdugo mountains along the top. The two dark strips near the coast at lower left are the runways of Los Angeles International Airport. Downtown Los Angeles is the bright yellow and pink area at lower center. Pasadena, including the Rose Bowl, are seen half way down the right edge of the image. The communities of Glendale and Burbank, including the Burbank Airport, are seen at the center of the top edge of the image. Hazards from earthquakes, floods and fires are intimately related to the topography in this area. Topographic data and other remote sensing images provide valuable information for assessing and mitigating the natural hazards for cities such as Leangles.

    This image combines two types of data from the Shuttle Radar Topography Mission. The image brightness corresponds to the strength of the radar signal reflected from the ground, while colors show the elevation as measured by SRTM. Each cycle of colors (from pink through blue back to pink) represents an equal amount of elevation difference (400 meters, or 1300 feet) similar to contour lines on a standard topographic map. This image contains about 2400 meters (8000 feet) of total relief.

    The Shuttle Radar Topography Mission (SRTM), launched on February 11,2000, uses the same radar instrument that comprised the Spaceborne Imaging Radar-C/X-Band Synthetic Aperture Radar (SIR-C/X-SAR) that flew twice on the Space Shuttle Endeavour in 1994. The mission is designed to collect three-dimensional measurements of the Earth's surface. To collect the 3-D data, engineers added a 60-meter-long (200-foot) mast, an additional C-band imaging antenna and improved tracking and navigation devices. The mission is a cooperative project between

  3. Los Alamos Science, Number 25 -- 1997: Celebrating the neutrino

    SciTech Connect

    Cooper, N.G.

    1997-12-31

    This issue is devoted to the neutrino and its remaining mysteries. It is divided into the following areas: (1) The Reines-Cowan experiment -- detecting the poltergeist; (2) The oscillating neutrino -- an introduction to neutrino masses and mixing; (3) A brief history of neutrino experiments at LAMPF; (4) A thousand eyes -- the story of LSND (Los Alamos neutrino oscillation experiment); (5) The evidence for oscillations; (6) The nature of neutrinos in muon decay and physics beyond the Standard Model; (7) Exorcising ghosts -- in pursuit of the missing solar neutrinos; (8) MSW -- a possible solution to the solar neutrino problem; (8) Neutrinos and supernovae; and (9) Dark matter and massive neutrinos.

  4. Los Alamos safeguards program overview and NDA in safeguards

    SciTech Connect

    Keepin, G.R.

    1988-01-01

    Over the years the Los Alamos safeguards program has developed, tested, and implemented a broad range of passive and active nondestructive analysis (NDA) instruments (based on gamma and x-ray detection and neutron counting) that are now widely employed in safeguarding nuclear materials of all forms. Here very briefly, the major categories of gamma ray and neutron based NDA techniques, give some representative examples of NDA instruments currently in use, and cite a few notable instances of state-of-the-art NDA technique development. Historical aspects and a broad overview of the safeguards program are also presented.

  5. Water supply at Los Alamos during 1995. Progress report

    SciTech Connect

    McLin, S.G.; Purtymun, W.D.; Maes, M.N.

    1997-04-01

    Production of potable municipal water supplies during 1995 totaled about 1,356.1 million gallons from wells in the Guaje and Pajarito well fields. Wells in the Otowi field were not operational during 1995. The nonpotable water supply for industrial use was about 1.6 million gallons from the spring gallery in Water Canyon, and another 1.6 million gallons from Los Alamos Reservoir was used for lawn irrigation. There was no water used from Guaje Reservoir in 1995. The total water usage in 1995 was about 1,359.3 million gallons. Groundwater pumpage during 1995 was the lowest on record since 1966.

  6. Water supply at Los Alamos during 1985: Progress report

    SciTech Connect

    Purtymun, W.D.; Becker, N.M.; Maes, M.N.

    1986-10-01

    Well field operations during 1985 were satisfactory with municipal and industrial supplies consisting of 1587 x 10/sup 6/ gal from wells in three well fields and 37 x 10/sup 6/ gal from the gallery in Water Canyon. About 2.8 x 10/sup 6/ gal of water from Guaje Reservoir and 0.9 x 10/sup 6/ gal from Los Alamos Reservoir were used for irrigation; thus the total water usage in 1985 was about 1628 x 10/sup 6/ gal. Primary and secondary chemical quality of water in the distribution system is in compliance with federal regulations.

  7. Using Research to Improve College Readiness: A Research Partnership between the Los Angeles Unified School District and the Los Angeles Education Research Institute

    ERIC Educational Resources Information Center

    Phillips, Meredith; Yamashiro, Kyo; Farrukh, Adina; Lim, Cynthia; Hayes, Katherine; Wagner, Nicole; White, Jeffrey; Chen, Hansheng

    2015-01-01

    The Los Angeles Unified School District (LAUSD) serves a large majority of socioeconomically disadvantaged students who are struggling academically and are underprepared for high school graduation and college. This article describes the partnership between LAUSD and the Los Angeles Education Research Institute, and how this collaboration endeavors…

  8. Let Book Joy Begin @ Your Library[R]!: Ten Years of El Dia de los Ninos/El Dia de los Libros

    ERIC Educational Resources Information Center

    Roy, Loriene

    2007-01-01

    Ten years ago, in 1996, poet and children's book author, Pat Mora began celebrating "book joy" by founding a children's book and reading day, El Dia de los Ninos/El Dia de los Libros or Children's Day/Book Day. Dia is modeled on National Children's Day Celebrations in Mexico held since 1925 when it was launched in conjunction with a…

  9. Industrial application for the Los Alamos Materials Modeling Platform

    SciTech Connect

    Lesar, R.; Charbon, C.; Kothe, D.; Wu, D.; Reddy, A.

    1996-09-01

    This is the final report of a one-year, Laboratory-Directed Research and Development (LDRD) project at the Los Alamos National Laboratory (LANL). Casting and solidification of molten metals and metal alloys is a critical step in the production of high-quality metal stock and in the fabrication of finished parts. Control of the casting process can be the determining factor in both the quality and cost of the final metal product. Major problems with the quality of cast stock or finished parts can arise because of the difficulty of preventing variations in the alloy content, the generation of porosity or poor surface finish, and the loss of microstructure controlled strength and toughness resulting from the poor understanding and design of the mold filling and solidification processes. In this project, we sought to develop a new set of applications focused on adding the ability to accurately model solidification and grain growth to casting simulations. We implemented these applications within the Los Alamos Materials Modeling Platform, LAMMP, a graphical-based materials, and materials modeling environment being created at the Computational Testbed for Industry.

  10. Exploding metallic foil fuse modeling at Los Alamos

    SciTech Connect

    Lindemuth, I.R.; Reinovsky, R.E.; Goforth, J.H.

    1989-01-01

    A ''first-principles'' computational model of exploding metallic foil behavior has been developed at Los Alamos. The model couples zero-dimensional magnetohydrodynamics with ohmic heating and electrical circuit equations and uses the Los Alamos SESAME atomic data base computer library to determine the foil material's temperature- and density-dependent pressure, specific energy, and electrical conductivity. The model encompasses many previously successful empirical models and offers plausible physical explanations of phenomena not treated by the empirical models. In addition to addressing the electrical circuit performance of an exploding foil, the model provides information on the temporal evolution of the foil material's density, temperature, pressure, electrical conductivity, and expansion and translational velocities. In this paper, we report the physical insight gained by computational studies of two opening switch concepts being developed for application in an FCG-driven 1-MJ-class imploding plasma z-pinch experiment. The first concept considered is a ''conventional'' electrically exploded fuse, which has been demonstrated to operate at 16 MA driven by the 15-MJ-class FCG to be used in the 1 MJ implosion experiment. The second concept considered is a Type 2 explosively formed fuse (EFF), which has been demonstrated to operate at the 8 MA level by a 1-MJ-class FCG.

  11. An organizational survey of the Los Alamos Site

    SciTech Connect

    Shurberg, D.A.; Haber, S.B.

    1991-11-01

    An Organizational Survey (OS) was administered at the Los Alamos Site that queried employees on the subjects of organizational culture, various aspects of communications, employee commitment, work group cohesion, coordination of work, environmental, safety, and health concern, hazardous nature of work, safety and overall job satisfaction. The purpose of the OS is to measure in a quantitative and objective way the notion of culture;'' that is, the values, attitudes, and beliefs of the individuals working within the organization. In addition, through the OS, a broad sample of individuals can be reached that would probably not be interviewed or observed during the course of a typical assessment. The OS also provides a descriptive profile of the organization at one point in time that can then be compared to a profile taken at a different point in time to assess changes in the culture of the organization. While comparisons among groups are made, it is not the purpose of this report to make evaluative statements of which profile may be positive or negative. However, using the data presented in this report in conjunction with other evaluative activities, may provide useful insight into the organization. The OS administration at the Los Alamos Site was the ninth to occur at a Department of Energy (DOE) facility. All data from the OS is presented in group summaries, by organization, department or directorate within organization, supervisory level both overall and within organization, and staff classification within organization. Statistically significant differences between groups are identified and discussed. 9 refs., 94 figs., 11 tabs.

  12. An organizational survey of the Los Alamos Site

    SciTech Connect

    Shurberg, D.A.; Haber, S.B.

    1991-11-01

    An Organizational Survey (OS) was administered at the Los Alamos Site that queried employees on the subjects of organizational culture, various aspects of communications, employee commitment, work group cohesion, coordination of work, environmental, safety, and health concern, hazardous nature of work, safety and overall job satisfaction. The purpose of the OS is to measure in a quantitative and objective way the notion of ``culture;`` that is, the values, attitudes, and beliefs of the individuals working within the organization. In addition, through the OS, a broad sample of individuals can be reached that would probably not be interviewed or observed during the course of a typical assessment. The OS also provides a descriptive profile of the organization at one point in time that can then be compared to a profile taken at a different point in time to assess changes in the culture of the organization. While comparisons among groups are made, it is not the purpose of this report to make evaluative statements of which profile may be positive or negative. However, using the data presented in this report in conjunction with other evaluative activities, may provide useful insight into the organization. The OS administration at the Los Alamos Site was the ninth to occur at a Department of Energy (DOE) facility. All data from the OS is presented in group summaries, by organization, department or directorate within organization, supervisory level both overall and within organization, and staff classification within organization. Statistically significant differences between groups are identified and discussed. 9 refs., 94 figs., 11 tabs.

  13. Fuels Inventories in the Los Alamos National Laboratory Region: 1997

    SciTech Connect

    Balice, R.G.; Oswald, B.P.; Martin, C.

    1999-03-01

    Fifty-four sites were surveyed for fuel levels, vegetational structures, and topographic characteristics. Most of the surveyed sites were on Los Alamos National Laboratory property, however, some surveys were also conducted on U.S. Forest Service property. The overall vegetation of these sites ranged from pinon-juniper woodlands to ponderosa pine forests to mixed conifer forests, and the topographic positions included canyons, mesas, and mountains. The results of these surveys indicate that the understory fuels are the greatest in mixed conifer forests and that overstory fuels are greatest in both mixed conifer forests and ponderosa pine forests on mesas. The geographic distribution of these fuels would suggest a most credible wildfire scenario for the Los Alamos region. Three major fires have occurred since 1954 and these fires behaved in a manner that is consistent with this scenario. The most credible wildfire scenario was also supported by the results of BEHAVE modeling that used the fuels inventory data as inputs. Output from the BEHAVE model suggested that catastrophic wildfires would continue to occur during any season with sufficiently dry, windy weather.

  14. Cleanup at Los Alamos National Laboratory - the challenges - 9493

    SciTech Connect

    Stiger, Susan G; Hargis, Kenneth M; Graham, Michael J; Rael, George J

    2008-01-01

    This paper provides an overview of environmental cleanup at the Los Alamos National Laboratory (LANL) and some of the unique aspects and challenges. Cleanup of the 65-year old Department of Energy Laboratory is being conducted under a RCRA Consent Order with the State of New Mexico. This agreement is one of the most recent cleanup agreements signed in the DOE complex and was based on lessons learned at other DOE sites. A number of attributes create unique challenges for LANL cleanup -- the proximity to the community and pueblos, the site's topography and geology, and the nature of LANL's on-going missions. This overview paper will set the stage for other papers in this session, including papers that present: Plans to retrieve buried waste at Material Disposal Area B, across the street from oen of Los Alamos' commercial districts and the local newspaper; Progress to date and joint plans with WIPP for disposal of the remaining inventory of legacy transuranic waste; Reviews of both groundwater and surface water contamination and the factors complicating both characterization and remediation; Optimizing the disposal of low-level radioactive waste from ongoing LANL missions; A stakeholder environmental data transparency project (RACER), with full public access to all available information on contamination at LANL, and A description of the approach to waste processing cost recovery from the programs that generate hazardous and radioactive waste at LANL.

  15. The Los Alamos suite of relativistic atomic physics codes

    DOE PAGES

    Fontes, C. J.; Zhang, H. L.; Jr, J. Abdallah; ...

    2015-05-28

    The Los Alamos SuitE of Relativistic (LASER) atomic physics codes is a robust, mature platform that has been used to model highly charged ions in a variety of ways. The suite includes capabilities for calculating data related to fundamental atomic structure, as well as the processes of photoexcitation, electron-impact excitation and ionization, photoionization and autoionization within a consistent framework. These data can be of a basic nature, such as cross sections and collision strengths, which are useful in making predictions that can be compared with experiments to test fundamental theories of highly charged ions, such as quantum electrodynamics. The suitemore » can also be used to generate detailed models of energy levels and rate coefficients, and to apply them in the collisional-radiative modeling of plasmas over a wide range of conditions. Such modeling is useful, for example, in the interpretation of spectra generated by a variety of plasmas. In this work, we provide a brief overview of the capabilities within the Los Alamos relativistic suite along with some examples of its application to the modeling of highly charged ions.« less

  16. Recent progress in the Los Alamos KrF Program

    SciTech Connect

    McDonald, T.E.; Cartwright, D.C.; Coggeshall, S.V.; Fenstermacher, C.A.; Figueira, J.F.; Foreman, L.R.; Goldstone, P.D.; Hanson, D.E.; Harris, D.B.; Hauer, A.A.

    1988-01-01

    The goal of the Inertial Confinement Fusion Program (ICF) is to develop the ability to ignite and burn small masses of thermonuclear fuel. Although the present near-term objectives of the program are directed toward defense applications, ICF research continues to be carried out with a view to the longer term goal of commercial power production. The characteristics of a KrF laser make it an attractive candidate as an ICF driver. The KrF wavelength of 248 nm provides a target coupling that is very high at intensities of 10/sup 14/w/cm/sup 2/. In addition, the KrF laser can be repetitively operated at frequencies appropriate for a power reactor and has an intrinsically high efficiency, which allows projections to the long-term goal of energy production. The ICF program at Los Alamos consists of driver development, target design and fabrication, and target experimentation. The major effort at present is the investigation and development of KrF technology to determine its applicability for use in a laboratory driver at Los Alamos. Such a driver would be used in defense related technology studies and in areas of scientific study such as highly ionized materials and high-energy-density physics.

  17. The Los Alamos universe: Using multimedia to promote laboratory capabilities

    SciTech Connect

    Kindel, J.

    2000-03-01

    This project consists of a multimedia presentation that explains the technological capabilities of Los Alamos National Laboratory. It takes the form of a human-computer interface built around the metaphor of the universe. The project is intended promote Laboratory capabilities to a wide audience. Multimedia is simply a means of communicating information through a diverse set of tools--be they text, sound, animation, video, etc. Likewise, Los Alamos National Laboratory is a collection of diverse technologies, projects, and people. Given the ample material available at the Laboratory, there are tangible benefits to be gained by communicating across media. This paper consists of three parts. The first section provides some basic information about the Laboratory, its mission, and its needs. The second section introduces this multimedia presentation and the metaphor it is based on along with some basic concepts of color and user interaction used in the building of this project. The final section covers construction of the project, pitfalls, and future improvements.

  18. Masculinity and HIV Risk among Homeless Men in Los Angeles

    PubMed Central

    Kennedy, David P.; Brown, Ryan A.; Golinelli, Daniela; Wenzel, Suzanne L.; Tucker, Joan S.; Wertheimer, Samuel R.

    2012-01-01

    HIV continues to be a serious public health problem for men who have sex with women (MSW), especially homeless MSW. Although consideration of gender has improved HIV prevention interventions, most of the research and intervention development has targeted how women’s HIV risk is affected by gender roles. The effect of gender roles on MSW has received relatively little attention. Previous studies have shown mixed results when investigating the association between internalization of masculine gender roles and HIV risk. These studies use a variety of scales that measure individual internalization of different aspects of masculinity. However, this ignores the dynamic and culturally constructed nature of gender roles. The current study uses cultural consensus analysis (CCA) to test for the existence of culturally agreed upon masculinity and gender role beliefs among homeless MSW in Los Angeles, as well as the relationship between these beliefs and HIV-related behaviors and attitudes. Interviews included 30 qualitative and 305 structured interviews with homeless MSW in Los Angeles’s Skid Row area. Analysis identified culturally relevant aspects of masculinity not represented by existing masculinity scales, primarily related to barriers to relationships with women. Behaviors, attitudes, and knowledge related to HIV were significantly associated with men’s level of agreement with the group about masculinity. The findings are discussed in light of implications for MSW HIV intervention development. PMID:23730216

  19. Investigation of excess thyroid cancer incidence in Los Alamos County

    SciTech Connect

    Athas, W.F.

    1996-04-01

    Los Alamos County (LAC) is home to the Los Alamos National Laboratory, a U.S. Department of Energy (DOE) nuclear research and design facility. In 1991, the DOE funded the New Mexico Department of Health to conduct a review of cancer incidence rates in LAC in response to citizen concerns over what was perceived as a large excess of brain tumors and a possible relationship to radiological contaminants from the Laboratory. The study found no unusual or alarming pattern in the incidence of brain cancer, however, a fourfold excess of thyroid cancer was observed during the late-1980`s. A rapid review of the medical records for cases diagnosed between 1986 and 1990 failed to demonstrate that the thyroid cancer excess had resulted from enhanced detection. Surveillance activities subsequently undertaken to monitor the trend revealed that the excess persisted into 1993. A feasibility assessment of further studies was made, and ultimately, an investigation was conducted to document the epidemiologic characteristics of the excess in detail and to explore possible causes through a case-series records review. Findings from the investigation are the subject of this report.

  20. The Los Alamos suite of relativistic atomic physics codes

    SciTech Connect

    Fontes, C. J.; Zhang, H. L.; Jr, J. Abdallah; Clark, R. E. H.; Kilcrease, D. P.; Colgan, J.; Cunningham, R. T.; Hakel, P.; Magee, N. H.; Sherrill, M. E.

    2015-05-28

    The Los Alamos SuitE of Relativistic (LASER) atomic physics codes is a robust, mature platform that has been used to model highly charged ions in a variety of ways. The suite includes capabilities for calculating data related to fundamental atomic structure, as well as the processes of photoexcitation, electron-impact excitation and ionization, photoionization and autoionization within a consistent framework. These data can be of a basic nature, such as cross sections and collision strengths, which are useful in making predictions that can be compared with experiments to test fundamental theories of highly charged ions, such as quantum electrodynamics. The suite can also be used to generate detailed models of energy levels and rate coefficients, and to apply them in the collisional-radiative modeling of plasmas over a wide range of conditions. Such modeling is useful, for example, in the interpretation of spectra generated by a variety of plasmas. In this work, we provide a brief overview of the capabilities within the Los Alamos relativistic suite along with some examples of its application to the modeling of highly charged ions.

  1. Teaching remote observation using telescopes at Aras de los Olmos

    NASA Astrophysics Data System (ADS)

    Ballesteros, F. J.; Gutiérrez-Soto, J.

    2015-05-01

    The Observatorio de Aras de los Olmos (OAO) is the observation station of the Astronomical Observatory of the University of Valencia. It is located in the town of Aras de los Olmos on top of the Muela de Santa Catalina mountain, one of the few dark places in the Valencian Community. The OAO has three remotely operable telescopes, with sizes of 40, 50 and 60 cm. As a general purpose observatory and due to its variety in the available instrumentation, the OAO offers a great flexibility in its observations. Among other activities, the OAO telescopes becomes a top-rated first-class teaching resource. In this contribution we present the remote observation system of the OAO telescopes. This system allows direct interaction with telescopes for a large number of students, from the classroom or from their homes. Experience during 2013--14 academic year at the Valencian International University was very satisfactory. The Observatory is now considering offering this service to other universities.

  2. Water supply at Los Alamos during 1994. Progress report

    SciTech Connect

    McLin, S.G.; Purtymun, W.D.; Stoker, A.K.; Maes, M.N.

    1996-10-01

    Production of potable municipal water supplies during 1994 totaled about 1,426.6 million gallons of wells in the Guaje, Pajarito, and Otowi Fields. The non-potable water supply for industrial use was about 11.6 million gallons from the spring gallery in Water Canyon. There was no water used for irrigation from Guaje or Los Alamos Reservoirs; thus, the total water usage in 1994 was about 1,438.2 million gallons. Pumps in Guaje Well 5 and Otowi Well 4 failed during the year and were not operational by the end of 1994. Water production resumed in Pajarito Well 3 in June. Wells in the Los Alamos Field, on Pueblo Land, were plugged and abandoned in 1992, or were transferred to San Ildefonso Pueblo. This report fulfills requirements which require the Laboratory to monitor and document groundwater conditions below Pajarito Plateau, and to protect the main aquifer from contamination associated with Laboratory operations by providing information on hydrologic characteristics of the main aquifer, including operating conditions of the municipal water supply system.

  3. Mixed low-level waste minimization at Los Alamos

    SciTech Connect

    Starke, T.P.

    1998-12-01

    During the first six months of University of California 98 Fiscal Year (July--December) Los Alamos National Laboratory has achieved a 57% reduction in mixed low-level waste generation. This has been accomplished through a systems approach that identified and minimized the largest MLLW streams. These included surface-contaminated lead, lead-lined gloveboxes, printed circuit boards, and activated fluorescent lamps. Specific waste minimization projects have been initiated to address these streams. In addition, several chemical processing equipment upgrades are being implemented. Use of contaminated lead is planned for several high energy proton beam stop applications and stainless steel encapsulated lead is being evaluated for other radiological control area applications. INEEL is assisting Los Alamos with a complete systems analysis of analytical chemistry derived mixed wastes at the CMR building and with a minimum life-cycle cost standard glovebox design. Funding for waste minimization upgrades has come from several sources: generator programs, waste management, the generator set-aside program, and Defense Programs funding to INEEL.

  4. Plutonium scrap processing at the Los Alamos Scientific Laboratory

    SciTech Connect

    Nixon, A.E.; McKerley, B.J.; Christensen, E.L.

    1980-01-01

    The Los Alamos Scientific Laboratory currently has the newest plutonium handling facility in the nation. Los Alamos has been active in the processing of plutonium almost since the discovery of this man-made element in 1941. One of the functions of the new facility is the processing of plutonium scrap generated at LASL and other sites. The feed for the scrap processing program is extremely varied, and a wide variety of contaminants are often encountered. Depending upon the scrap matrix and contaminants present, the majority of material receives a nitric acid/hydrofluoric acid or nitric acid/calcium fluoride leach. The plutonium nitrate solutions are then loaded onto an anion exchange column charged with DOWEX 1 x 4, 50 to 100 mesh, nitrate form resin. The column is eluted with 0.48 M hydroxyl amine nitrate. The Pu(NO/sub 3/)/sub 3/ is then precipitated as plutonium III oxalate which is calcined at 450 to 500/sup 0/C to yield a purified PuO/sub 2/ product.

  5. Environmental Assessment for Electrical Power System Upgrades at Los Alamos National Laboratory, Los Alamos, New Mexico - Final Document

    SciTech Connect

    N /A

    2000-03-09

    The ''National Environmental Policy Act of 1969'' (NEPA) requires Federal agency officials to consider the environmental consequences of their proposed actions before decisions are made. In complying with NEPA, the United States (U.S.) Department of Energy (DOE) follows the Council on Environmental Quality (CEQ) regulations (40 Code of Federal Regulations [CFR] 1500-1508) and DOE's NEPA implementing procedures (10 CFR 1021). The purpose of an Environmental Assessment (EA) is to provide Federal decision makers with sufficient evidence and analysis to determine whether to prepare an Environmental Impact Statement (EIS) or issue a Finding of No Significant Impact. In this case, the DOE decision to be made is whether to construct and operate a 19.5-mile (mi) (31-kilometer [km]) electric transmission line (power line) reaching from the Norton Substation, west across the Rio Grande, to locations within the Los Alamos National Laboratory (LANL) Technical Areas (TAs) 3 and 5 at Los Alamos, New Mexico. The construction of one electric substation at LANL would be included in the project as would the construction of two line segments less than 1,200 feet (ft) (366 meters [m]) long that would allow for the uncrossing of a portion of two existing power lines. Additionally, a fiber optics communications line would be included and installed concurrently as part of the required overhead ground conductor for the power line. The new power line would improve the reliability of electric service in the LANL and Los Aktrnos County areas as would the uncrossing of the crossed segments of the existing lines. Additionally, installation of the new power line would enable the LANL and the Los Alamos County electric grid, which is a shared resource, to be adapted to accommodate the future import of increased power when additional power service becomes available in the northern New Mexico area. Similarly, the fiber optics line would allow DOE to take advantage of future opportunities in

  6. La utilizacion de los mapas conceptuales en la ensenanza de biologia y su efecto sobre el dominio del proceso de fotosintesis en los estudiantes universitarios

    NASA Astrophysics Data System (ADS)

    Gonzalez Rivera, Maria M.

    Se investigo el efecto de los mapas conceptuales sobre el dominio del proceso de fotosintesis en estudiantes universitarios. La investigacion utilizo dos estrategias: mapas conceptuales individuales y mapas conceptuales colaborativos, con el fin de investigar si existen diferencias significativas en el dominio del proceso de fotosintesis. El analisis de los datos incluyo aspectos cualitativos y cuantitativos. Se desprende del estudio que el 80% de los estudiantes describen la utilizacion de los mapas conceptuales como una experiencia beneficiosa. El 70% de los estudiantes expreso que los mapas conceptuales son utiles en el aprendizaje del proceso de fotosintesis y el 61% indico que facilitan la comprension de los conceptos. Los hallazgos mas importantes del analisis cuantitativo indican que los estudiantes que utilizaron los mapas conceptuales mejoraron significativamente su desempeno en la posprueba global. Se utilizo la prueba Mann-Whitney para investigar si existian diferencias significativas en la posprueba y preprueba global, el valor de W = 1945.0, para un valor p de 0.00, lo cual establece diferencias significativas. Para determinar si existian diferencias significativas entre la posprueba y preprueba del grupo individual, se realizo la prueba nuevamente. El valor de W correspondio a 490.5, que es significativo, con un valor p de 0.00. Se concluye que existen diferencias significativas entre la ejecucion de la posprueba y preprueba del grupo individual. Los datos proveen suficiente evidencia para sostener que los estudiantes que utilizaron la estrategia de mapas conceptuales individuales mejoraron el dominio del proceso de fotosintesis significativamente. Se realizo nuevamente la prueba para los resultados de posprueba y preprueba del grupo colaborativo. El valor de W correspondio a 446 con un valor p de 0.00. Se concluyo que existen diferencias significativas entre la ejecucion de la posprueba y preprueba del grupo colaborativo. Finalmente, se efectuo una

  7. Reconnaissance assessment of erosion and sedimentation in the Canada de los Alamos basin, Los Angeles and Ventura Counties, California

    USGS Publications Warehouse

    Knott, J.M.

    1980-01-01

    An assessment of present erosion and sedimentation conditions in the Ca?ada de los Alamos basin was made to aid in estimating the impact of off-road-vehicle use on the sediment yield of the basin. Impacts of off-road vehicles were evaluated by reconnaissance techniques and by comparing the study area with other offroad-vehicle sites in California. Major-storm sediment yields for the basin were estimated using empirical equations developed for the Transverse Ranges and measurements of gully erosion in a representative off-road-vehicle basin. Normal major-storm yields of 73,200 cubic yards would have to be increased to about 98,000 cubic yards to account for the existing level of accelerated erosion caused by off-road vehicles. Long-term sediment yield of the Ca?ada de los Alamos basin upstream from its confluence with Gorman Creek, under present conditions of off-road-vehicle use, is approximately 420 cubic yards per square mile per year--a rate that is considerably lower than a previous estimate of 1,270 cubic yards per square mile per year for the total catchment area above Pyramid Lake.

  8. Reconnaissance assessment of erosion and sedimentation in the Canada de los Alamos Basin, Los Angeles and Ventura counties, California

    USGS Publications Warehouse

    Knott, J.M.

    1978-01-01

    An assessment of present erosion and sedimentation conditions in the Canada de Los Alamos basin, Calif., was made to aid in estimating the impact of off-road-vehicle use on the sediment yield of the basin. Evaluations were made by reconnaissance techniques and by comparing the study area with other off-road-vehicle sites in California. Major-storm sediment yields for the basin were estimated, using empirical equations developed for the Transverse Ranges and measurements of gully erosion in a representative off-road vehicle basin. Normal major-storm yields of 73,200 cubic yards would have to be increased to about 98,000 cubic yards to account for the existing level of accelerated erosion caused by off-road vehicles. Long-term sediment yield of the Canada de Los Alamos basin upstream from its confluence with Gorman Creek, under present conditions of off-road-vehicle use, is approximately 420 cubic yards per square mile per year--a rate that is considerably lower than a previous estimate of 1,270 cubic yards per square mile per year for the total catchment area above Pyramid Lake. (Woodard-USGS)

  9. Construction and Characterization of Haemophilus ducreyi Lipooligosaccharide (LOS) Mutants Defective in Expression of Heptosyltransferase III and β1,4-Glucosyltransferase: Identification of LOS Glycoforms Containing Lactosamine Repeats

    PubMed Central

    Filiatrault, Melanie J.; Gibson, Bradford W.; Schilling, Birgit; Sun, Shuhua; Munson, Robert S.; Campagnari, Anthony A.

    2000-01-01

    To begin to understand the role of the lipooligosaccharide (LOS) molecule in chancroid infections, we constructed mutants defective in expression of glycosyltransferase genes. Pyocin lysis and immunoscreening was used to identify a LOS mutant of Haemophilus ducreyi 35000. This mutant, HD35000R, produced a LOS molecule that lacked the monoclonal antibody 3F11 epitope and migrated with an increased mobility on sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). Structural studies indicated that the principal LOS glycoform contains lipid A, Kdo, and two of the three core heptose residues. HD35000R was transformed with a plasmid library of H. ducreyi 35000 DNA, and a clone producing the wild-type LOS was identified. Sequence analysis of the plasmid insert revealed one open reading frame (ORF) that encodes a protein with homology to the WaaQ (heptosyltransferase III) of Escherichia coli. A second ORF had homology to the LgtF (glucosyltransferase) of Neisseria meningitidis. Individual isogenic mutants lacking expression of the putative H. ducreyi heptosyltransferase III, the putative glucosyltransferase, and both glycosyltransferases were constructed and characterized. Each mutant was complemented with the representative wild-type genes in trans to restore expression of parental LOS and confirm the function of each enzyme. Matrix-assisted laser desorption ionization mass spectrometry and SDS-PAGE analysis identified several unique LOS glycoforms containing di-, tri-, and poly-N-acetyllactosamine repeats added to the terminal region of the main LOS branch synthesized by the heptosyltransferase III mutant. These novel H. ducreyi mutants provide important tools for studying the regulation of LOS assembly and biosynthesis. PMID:10816485

  10. Common ground: An environmental ethic for Los Alamos National Laboratory

    SciTech Connect

    Menlove, F.L.

    1991-01-01

    Three predominant philosophies have characterized American business ethical thinking over the past several decades. The first phase is the ethics of self-interest'' which argues that maximizing self-interest coincidentally maximizes the common good. The second phase is legality ethics.'' Proponents argue that what is important is knowing the rules and following them scrupulously. The third phase might be called stake-holder ethics.'' A central tenant is that everyone affected by a decision has a moral hold on the decision maker. This paper will discuss one recent initiative of the Los Alamos National Laboratory to move beyond rules and regulations toward an environmental ethic that integrates the values of stakeholder ethics'' into the Laboratory's historical culture and value systems. These Common Ground Principles are described. 11 refs.

  11. Thermal extraction analysis of five Los Azufres production wells

    SciTech Connect

    Kruger, Paul; Quijano, Luis

    1995-01-26

    Thermal energy extraction from five wells supplying 5-MWe wellhead generators in three zones of the Los Azufres geothermal field has been examined from production and chemical data compiled over 14-years of operation. The data, as annual means, are useful in observing small-scale changes in reservoir performance with continuous production. The chemical components are chloride for quality control and the geothermometer elements for reservoir temperatures. The flowrate and fluid enthalpy data are used to calculate the thermal extraction rates. Integration of these data provides an estimate of the total energy extracted from the zone surrounding the well. The combined production and chemical geothermometer data are used to model the produced fluid as coming from just-penetrating wells for which the annual produced mass originates from a series of concentric hemispheric shells moving out into the reservoir. Estimates are made of the drawdown distance into the reservoir and the far-field conditions.

  12. The legacy and future of CFD at Los Alamos

    SciTech Connect

    Johnson, N.L.

    1996-06-01

    The early history is presented of the prolific development of CFD methods in the Fluid Dynamics Group (T-3) at Los Alamos National Laboratory in the years from 1958 to the late 1960`s. Many of the currently used numerical methods--PIC, MAC, vorticity-stream-function, ICE, ALE methods and the {kappa}-{var_epsilon} method for turbulence--originated during this time. The rest of the paper summarizes the current research in T-3 for CFD, turbulence and solids modeling. The research areas include reactive flows, multimaterial flows, multiphase flows and flows with spatial discontinuities. Also summarized are modern particle methods and techniques developed for large scale computing on massively parallel computing platforms and distributed processors.

  13. Los Alamos Guns Take Aim at Material's Mysteries

    SciTech Connect

    Byers, Mark; Moore, David; Dimarino, Steve

    2014-04-14

    Los Alamos National Laboratory scientists and technicians conduct thousands of experiments a year, delving into the fundamental nature of everything from supernovas to subatomic particles. One set of instruments used to better understand the fundamental nature of various materials are 10 scientific gun systems that fire various projectiles at high-tech targets to create enormous velocities, pressures, and temperatures - and using laser, x-ray, and other diagnostics - explore the very nature of metals and other materials. The hundreds of gun-based experiments conducted every year at the Laboratory require a highly-skilled staff of scientists and technicians, and has given rise to a special organization called the "gun working group" to foster open communications, cooperation, problem-solving, and a healthy safety culture.

  14. Environmental surveillance and compliance at Los Alamos during 1996

    SciTech Connect

    1997-09-01

    This report presents environmental data that characterize environmental performance and addresses compliance with environmental standards and requirements at Los Alamos National Laboratory (LANL or the Laboratory) during 1996. The Laboratory routinely monitors for radiation and for radioactive nonradioactive materials at Laboratory sites as well as in the surrounding region. LANL uses the monitoring results to determine compliance with appropriate standards and to identify potentially undesirable trends. Data were collected in 1996 to assess external penetrating radiation; quantities of airborne emissions; and concentrations of chemicals and radionuclides in ambient air, surface waters and groundwaters, the municipal water supply, soils and sediments, and foodstuffs. Using comparisons with standards and regulations, this report concludes that environmental effects from Laboratory operations are small and do not pose a demonstrable threat to the public, Laboratory employees, or the environment. Laboratory operations were in compliance with all major environmental regulations.

  15. Root lengths of plants on Los Alamos National Laboratory lands

    SciTech Connect

    Tierney, G.D.; Foxx, T.S.

    1987-01-01

    Maximum root lengths of 22 plant species occurring on Los Alamos National Laboratory lands were measured. An average of two longest roots from each species were dug up and their lengths, typical shapes, and qualitative morphologics were noted along with the overstory dimensions of the plant individual with which the roots were associated. Maximum root lengths were compared with overstory (height times width) dimensions. Among the life forms studied, the shrubs tend to show the longest roots in relation to overstory size. Forbs show the shortest roots in relation to overstory size. Measurements of tree roots suggest only that immature trees on the Pajarito Plateau may have root-length to overstory-size ratios near one. 30 refs., 14 figs., 2 tabs.

  16. Los Alamos Discovers Super Efficient Solar Using Perovskite Crystals

    ScienceCinema

    Mohite, Aditya; Nie, Wanyi

    2016-07-12

    State-of-the-art photovoltaics using high-purity, large-area, wafer-scale single-crystalline semiconductors grown by sophisticated, high temperature crystal-growth processes offer promising routes for developing low-cost, solar-based clean global energy solutions for the future. Solar cells composed of the recently discovered material organic-inorganic perovskites offer the efficiency of silicon, yet suffer from a variety of deficiencies limiting the commercial viability of perovskite photovoltaic technology. In research to appear in Science, Los Alamos National Laboratory researchers reveal a new solution-based hot-casting technique that eliminates these limitations, one that allows for the growth of high-quality, large-area, millimeter-scale perovskite crystals and demonstrates that highly efficient and reproducible solar cells with reduced trap assisted recombination can be realized.

  17. Risk factors for meningiomas in men in Los Angeles County.

    PubMed

    Preston-Martin, S; Yu, M C; Henderson, B E; Roberts, C

    1983-05-01

    A case-control study among men in Los Angeles County was conducted to investigate further the causes of intracranial meningiomas. Meningioma patients and a neighbor of each one were interviewed about past experiences that might be associated with tumor development. Analysis of information from the 105 matched pairs showed an association with meningioma occurrence for various factors relating to head trauma and head X-rays: 1) ever boxed as a sport [odds ratio (OR) = 2.0, P = 0.03], 2) had a serious head injury (OR = 1.9, P = 0.01), and 3) had X-ray treatment to the head before 20 years of age and/or had five or more full mouth dental X-ray series before 1945 (OR = 3.5, P = 0.02). Of the 105 subjects, 72 (69%) had a history of exposure to at least one of these factors.

  18. Los grandes telescopios ópticos e infrarrojos

    NASA Astrophysics Data System (ADS)

    Rodríguez-Espinosa, J. M.

    Recientemente se han puesto en funcionamiento telescopios de 8 y 10 metros de diámetro de su espejo primario que están significando un gran avance en las capacidades observacionales de la Astronomía moderna. Igualmente en nuestro país se está construyendo el Gran Telescopio de Canarias (GTC) que situará a la Astronomía española en la vanguardia de esta disciplina. En mi charla hablaré de las oportunidades observacionales que suponen estos grandes telescopios para la Astronomía moderna. Hablaré del GTC y del esfuerzo español por ser actores principales del desarrollo de la Astronomía moderna. Por último, mostraré brevemente los proyectos futuros de grandes telescopios que se están proponiendo a ambos lados del Atlántico.

  19. Los Alamos National Laboratory capability reviews - FY 2011 status

    SciTech Connect

    Springer, Everett P

    2011-01-12

    Capability reviews are the Los Alamos National Laboratory approach to assess the quality of its science, technology, and engineering (STE), and its integration across the Laboratory. There are seven capability reviews in FY 2011 reviews. The Weapons Science and Engineering review will be replaced by the National Nuclear Security Administration's Predictive Science Panel for 2011 . Beginning in 2011, third-year LORD projects will be reviewed by capability review committees rather than the first-year LORD projects that have been performed for the last three years. This change addresses concerns from committees about reviewing a project before it had made any substantive progress. The current schedule, and chairs for the 2011 capability reviews is presented. The three-year cycle (2011-2013) for capability reviews are presented for planning purposes.

  20. Mushroom growing project at the Los Humeros, Mexico geothermal field

    SciTech Connect

    Rangel, M.E.R.

    1998-12-01

    There are several projects of direct (non-electrical) use of geothermal energy in Mexico. Personnel of the Comision Federal de Electricidad (CFE) have experience in various of these projects, like drying of timber and fruits, space heating, food processing, etc. Taking this in consideration, CFE built the Los Humeros mushroom plant using for heat source the geothermal steam from Well H-1. The main purpose of the project was to take advantage of residual geothermal energy in a food production operation and to develop the appropriate technology. In 1992, existing installations were renovated, preparing appropriate areas for pasteurization, inoculation and production. The mushroom Pleurotus ostreatus var. florida and columbinus was used. A year later, CFE proposed the construction of improved facilities for growing edible mushrooms. New materials and equipment, as well as different operation conditions, were proposed on the basis of the experience gained in the initial project. The construction and renovation activities were completed in 1994.