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Sample records for low-dose-rate continuous gamma-ray

  1. Cause of death and neoplasia in mice continuously exposed to very low dose rates of gamma rays.

    PubMed

    Tanaka, I B; Tanaka, S; Ichinohe, K; Matsushita, S; Matsumoto, T; Otsu, H; Oghiso, Y; Sato, F

    2007-04-01

    Four thousand 8-week-old SPF B6C3F1 mice (2000 of each sex) were divided into four groups, one nonirradiated (control) and three irradiated. The irradiated groups were exposed to (137)Cs gamma rays at dose rates of 21, 1.1 and 0.05 mGy day(-1) for approximately 400 days with total doses equivalent to 8000, 400 and 20 mGy, respectively. All mice were kept until natural death, and pathological examination was performed to determine the cause of death. Neoplasms accounted for >86.7% of all deaths. Compared to the nonirradiated controls, the frequency of myeloid leukemia in males, soft tissue neoplasms and malignant granulosa cell tumors in females, and hemangiosarcoma in both sexes exposed to 21 mGy day(-1) were significantly increased. The number of multiple primary neoplasms per mouse was significantly increased in mice irradiated at 21 mGy day(-1). Significant increases in body weights were observed from 32 to 60 weeks of age in males and females exposed to 1.1 mGy day(-1) and 21 mGy day(-1), respectively. Our results suggest that life shortening (Tanaka et al., Radiat. Res. 160, 376-379, 2003) in mice continuously exposed to low-dose-rate gamma rays is due to early death from a variety of neoplasms and not from increased incidence of specific neoplasms.

  2. Pathology of Serially Sacrificed Female B6C3F1 Mice Continuously Exposed to Very Low-Dose-Rate Gamma Rays.

    PubMed

    Tanaka, I B; Komura, J; Tanaka, S

    2017-03-01

    We have previously reported on life span shortening as well as increased incidence rates in several neoplasms in B6C3F1 mice that were continuously exposed to 21 mGy/day of gamma rays for 400 days. To clarify whether the life shortening was due to early appearance of neoplasms (shortened latency) or increased promotion/progression, 8-week-old female specific-pathogen-free B6C3F1 mice were gamma-ray irradiated at a low dose rate of 20 mGy/day for 400 days. At 100 days postirradiation, 60-90 mice were sacrificed, and thereafter every 100 days alongside the age-matched nonirradiated controls, for 700 days. Additional groups were allowed to live out their natural life span. Pathological examination was performed on all mice to identify lesions, non-neoplastic and neoplastic, as well as to determine the cause of death. Body weights were significantly increased in irradiated mice from sacrifice days 200-500. Incidence rates for spontaneously occurring non-neoplastic lesions, such as adrenal subcapsular cell hyperplasia, fatty degeneration of the liver, atrophy and tubulostromal hyperplasia of the ovaries, were significantly increased in irradiated mice. Significantly increased incidence rates with no shortening of latency periods were observed in irradiated mice for malignant lymphomas, hepatocellular adenomas/carcinomas, bronchioloalveolar adenomas, harderian gland adenoma/adenocarcinoma. Shortened latencies with significantly increased incidence rates were observed for adrenal subcapsular cell adenomas and ovarian neoplasms (tubulostromal adenoma, granulosa cell tumors) in irradiated mice. Life span shortening in mice exposed to 20 mGy/day was mostly due to malignant lymphomas. Multiple primary neoplasms were significantly increased in mice exposed to 20 mGy/day from sacrifice days 400-700 and in the life span group. Our results confirm that continuous low-dose-rate gamma-ray irradiation of female B6C3F1 mice causes both cancer induction (shortened latency) and

  3. Expression of Genes Associated with DNA Damage Sensing in Human Fibroblasts Exposed to Low-dose-rate Gamma Rays

    NASA Technical Reports Server (NTRS)

    Zhang, Ye; Mehta, Satish; Hammond, Diane; Pierson, Duane; Jeevarajan, Antony; Cucinotta, Francis; Rohde, Larry; Wu, Honglu

    2007-01-01

    Understanding of the molecular response to low-dose and low-dose-rate radiation exposure is essential for the extrapolation of high-dose radiation risks to those at dose levels relevant to space and other environmental concerns. Most of the reported studies of gene expressions induced by low-dose or low-dose-rate radiation were carried out on exponentially growing cells. In the present study, we analyzed expressions of 84 genes associated with DNA damage sensing using real time PCR in human fibroblasts in mostly G1 phase of the cell cycle. The cells were exposed continuously to gamma rays at a dose rate of 0.8 cGy/hr for 1, 2, 6 or 24 hrs at 37 C throughout the exposure. The total RNA was isolated immediately after the exposure was terminated. Of the 84 genes, only a few showed significant changes of the expression level. Some of the genes (e.g. DDit3 and BTG2) were found to be up or down regulated only after a short period of exposure, while other genes (e.g. PRKDC) displayed a highest expression level at the 24 hr time point. The expression profiles for the exposed cells which had a smaller portion of G1 cells indicated more cell cycle signaling and DNA repair genes either up or down regulated. Interestingly, the panel of genes changed from radiation exposure in G1 cells is different from the panel in cells having less G1 arrest cells. The gene expression profile of the cells responding to low-dose-radiation insult apparently depends on the cell growth stage. The response pathway in G1 cells may differ from that in exponentially growing cells.

  4. Expression of Genes Associated with DNA Damage Sensing in Human Fibroblasts Exposed to Low-dose-rate Gamma Rays

    NASA Technical Reports Server (NTRS)

    Zhang, Ye; Mehta, Satish; Hammond, Diane; Pierson, Duane; Jeevarajan, Antony; Cucinotta, Francis; Rohde, Larry; Wu, Honglu

    2007-01-01

    Understanding of the molecular response to low-dose and low-dose-rate radiation exposure is essential for the extrapolation of high-dose radiation risks to those at dose levels relevant to space and other environmental concerns. Most of the reported studies of gene expressions induced by low-dose or low-dose-rate radiation were carried out on exponentially growing cells. In the present study, we analyzed expressions of 84 genes associated with DNA damage sensing using real time PCR in human fibroblasts in mostly G1 phase of the cell cycle. The cells were exposed continuously to gamma rays at a dose rate of 0.8 cGy/hr for 1, 2, 6 or 24 hrs at 37 C throughout the exposure. The total RNA was isolated immediately after the exposure was terminated. Of the 84 genes, only a few showed significant changes of the expression level. Some of the genes (e.g. DDit3 and BTG2) were found to be up or down regulated only after a short period of exposure, while other genes (e.g. PRKDC) displayed a highest expression level at the 24 hr time point. The expression profiles for the exposed cells which had a smaller portion of G1 cells indicated more cell cycle signaling and DNA repair genes either up or down regulated. Interestingly, the panel of genes changed from radiation exposure in G1 cells is different from the panel in cells having less G1 arrest cells. The gene expression profile of the cells responding to low-dose-radiation insult apparently depends on the cell growth stage. The response pathway in G1 cells may differ from that in exponentially growing cells.

  5. Microarray analysis of differentially expressed genes in the kidneys and testes of mice after long-term irradiation with low-dose-rate gamma-rays.

    PubMed

    Taki, Keiko; Wang, Bing; Nakajima, Tetsuo; Wu, Jianyu; Ono, Tetsuya; Uehara, Yoshihiko; Matsumoto, Tsuneya; Oghiso, Yoichi; Tanaka, Kimio; Ichinohe, Kazuaki; Nakamura, Shingo; Tanaka, Satoshi; Magae, Junji; Kakimoto, Ayana; Nenoi, Mitsuru

    2009-05-01

    Measuring global gene expression using cDNA or oligonucleotide microarrays is an effective approach to understanding the complex mechanisms of the effects of radiation. However, few studies have been carried out that investigate gene expression in vivo after prolonged exposure to low-dose-rate radiation. In this study, C57BL/6J mice were continuously irradiated with gamma-rays for 485 days at dose-rates of 0.032-13 microGy/min. Gene expression profiles in the kidney and testis from irradiated and unirradiated mice were analyzed, and differentially expressed genes were identified. A combination of pathway analysis and hierarchical clustering of differentially expressed genes revealed that expression of genes involved in mitochondrial oxidative phosphorylation was elevated in the kidney after irradiation at the dose-rates of 0.65 microGy/min and 13 microGy/min. Expression of cell cycle-associated genes was not profoundly modulated in the kidney, in contrast to the response to acute irradiation, suggesting a threshold in the dose-rate for modulation of the expression of cell cycle-related genes in vivo following exposure to radiation. We demonstrated that changes to the gene expression profile in the testis were largely different from those in the kidney. The Gene Ontology categories "DNA metabolism", "response to DNA damage" and "DNA replication" overlapped significantly with the clusters of genes whose expression decreased with an increase in the dose-rate to the testis. These observations provide a fundamental insight into the organ-specific responses to low-dose-rate radiation.

  6. mBAND analysis of chromosome aberrations in human epithelial cells induced by gamma-rays and secondary neutrons of low dose rate.

    PubMed

    Hada, M; Gersey, B; Saganti, P B; Wilkins, R; Cucinotta, F A; Wu, H

    2010-08-14

    Human risks from chronic exposures to both low- and high-LET radiation are of intensive research interest in recent years. In the present study, human epithelial cells were exposed in vitro to gamma-rays at a dose rate of 17 mGy/h or secondary neutrons of 25 mGy/h. The secondary neutrons have a broad energy spectrum that simulates the Earth's atmosphere at high altitude, as well as the environment inside spacecrafts like the Russian MIR station and the International Space Station (ISS). Chromosome aberrations in the exposed cells were analyzed using the multicolor banding in situ hybridization (mBAND) technique with chromosome 3 painted in 23 colored bands that allows identification of both inter- and intrachromosome exchanges including inversions. Comparison of present dose responses between gamma-rays and neutron irradiations for the fraction of cells with damaged chromosome 3 yielded a relative biological effectiveness (RBE) value of 26+/-4 for the secondary neutrons. Our results also revealed that secondary neutrons of low dose rate induced a higher fraction of intrachromosome exchanges than gamma-rays, but the fractions of inversions observed between these two radiation types were indistinguishable. Similar to the previous findings after acute radiation exposures, most of the inversions observed in the present study were accompanied by other aberrations. The fractions of complex type aberrations and of unrejoined chromosomal breakages were also found to be higher in the neutron-exposed cells than after gamma-rays. We further analyzed the location of the breaks involved in chromosome aberrations along chromosome 3, and observed hot spots after gamma-ray, but not neutron, exposures.

  7. M-BAND Analysis of Chromosome Aberration In Human Epithelial Cells exposed to Gamma-ray and Secondary Neutrons of Low Dose Rate

    NASA Technical Reports Server (NTRS)

    Hada, M.; Saganti, P. B.; Gersey, B.; Wilkins, R.; Cucinotta, F. A.; Wu, H.

    2007-01-01

    High-energy secondary neutrons, produced by the interaction of galactic cosmic rays with the atmosphere, spacecraft structure and planetary surfaces, contribute to a significant fraction to the dose equivalent in crew members and passengers during commercial aviation travel, and astronauts in space missions. The Los Alamos Nuclear Science Center (LANSCE) neutron facility's "30L" beam line is known to generate neutrons that simulate the secondary neutron spectrum of the Earth's atmosphere at high altitude. The neutron spectrum is also similar to that measured onboard spacecraft like the MIR and the International Space Station (ISS). To evaluate the biological damage, we exposed human epithelial cells in vitro to the LANSCE neutron beams at an entrance dose rate of 2.5 cGy/hr or gamma-ray at 1.7cGy/hr, and assessed the induction of chromosome aberrations that were identified with mBAND. With this technique, individually painted chromosomal bands on one chromosome allowed the identification of inter-chromosomal aberrations (translocation to unpainted chromosomes) and intra-chromosomal aberrations (inversions and deletions within a single painted chromosome). Compared to our previous results for gamma-rays and 600 MeV/nucleon Fe ions of high dose rate, the neutron data showed a higher frequency of chromosome aberrations. However, detailed analysis of the inversion type revealed that all of the three radiation types in the study induced a low incidence of simple inversions. The low dose rate gamma-rays induced a lower frequency of chromosome aberrations than high dose rate gamma-rays, but the inversion spectrum was similar for the same cytotoxic effect. The distribution of damage sites on chromosome 3 for different radiation types will also be discussed.

  8. M-BAND Analysis of Chromosome Aberration In Human Epithelial Cells exposed to Gamma-ray and Secondary Neutrons of Low Dose Rate

    NASA Technical Reports Server (NTRS)

    Hada, M.; Saganti, P. B.; Gersey, B.; Wilkins, R.; Cucinotta, F. A.; Wu, H.

    2007-01-01

    High-energy secondary neutrons, produced by the interaction of galactic cosmic rays with the atmosphere, spacecraft structure and planetary surfaces, contribute to a significant fraction to the dose equivalent in crew members and passengers during commercial aviation travel, and astronauts in space missions. The Los Alamos Nuclear Science Center (LANSCE) neutron facility's "30L" beam line is known to generate neutrons that simulate the secondary neutron spectrum of the Earth's atmosphere at high altitude. The neutron spectrum is also similar to that measured onboard spacecraft like the MIR and the International Space Station (ISS). To evaluate the biological damage, we exposed human epithelial cells in vitro to the LANSCE neutron beams at an entrance dose rate of 2.5 cGy/hr or gamma-ray at 1.7cGy/hr, and assessed the induction of chromosome aberrations that were identified with mBAND. With this technique, individually painted chromosomal bands on one chromosome allowed the identification of inter-chromosomal aberrations (translocation to unpainted chromosomes) and intra-chromosomal aberrations (inversions and deletions within a single painted chromosome). Compared to our previous results for gamma-rays and 600 MeV/nucleon Fe ions of high dose rate, the neutron data showed a higher frequency of chromosome aberrations. However, detailed analysis of the inversion type revealed that all of the three radiation types in the study induced a low incidence of simple inversions. The low dose rate gamma-rays induced a lower frequency of chromosome aberrations than high dose rate gamma-rays, but the inversion spectrum was similar for the same cytotoxic effect. The distribution of damage sites on chromosome 3 for different radiation types will also be discussed.

  9. Total Ionizing Dose Response of Hafnium-Oxide Based MOS Devices to Low-Dose-Rate Gamma Ray Radiation Observed by Pulse CV and On-Site Measurements

    NASA Astrophysics Data System (ADS)

    Mu, Yifei; Zhao, Ce Zhou; Lu, Qifeng; Zhao, Chun; Qi, Yanfei; Lam, Sang; Mitrovic, Ivona Z.; Taylor, Stephen; Chalker, Paul R.

    2017-01-01

    This paper reports on the low-dose-rate radiation response of Al-HfO2/SiO2-Si MOS devices, where the gate dielectric was formed by atomic layer deposition with 4.7 nm equivalent oxide thickness. The degradation of the devices was characterized by a pulse capacitance-voltage (CV) and on-site radiation response techniques under continuous gamma (γ) ray exposure at a relatively low-dose-rate of 0.116 rad(HfO2)/s. A significant variation of the flat-band voltage shift of up to ± 1.1 V under positive and negative biased irradiation, with the total dose of up to 40 krad (HfO2) and the electric field of 0.5 MV/cm, has been measured on the HfO2-based MOS devices using the proposed techniques, not apparent by conventional CV measurements. The large flat-band voltage shift is mainly attributed to the radiation-induced oxide trapped charges, which are not readily compensated by bias-induced charges produced over the measurement timescales of less than 5 ms. Analysis of the experimental results suggest that both hole and electron trapping can dominate the radiation response performance of the HfO2-based MOS devices depending on the applied bias. No distinct loop width variation has been found with irradiation in all cases.

  10. Influence of germ cells upon Sertoli cells during continuous low-dose rate gamma-irradiation of adult rats.

    PubMed

    Pinon-Lataillade, G; Vélez de la Calle, J F; Viguier-Martinez, M C; Garnier, D H; Folliot, R; Maas, J; Jégou, B

    1988-07-01

    The effects of continuous gamma-irradiation of adult rats at two low-dose rates (7 cGy and 12 cGy/day; up to a total dose of 9.1 Gy and 10.69 Gy 60Co gamma-ray, respectively) were investigated. Over a period of 3-131 days of irradiation, groups of experimental and control animals were killed. Body weight, testis, epididymis, prostate and seminal vesicle weights, the number of germ cells and Sertoli cells, tubular ultrastructure, epididymal and testicular levels of biologically active androgen-binding protein (ABP), and the plasma concentrations of follicle-stimulating hormone (FSH), luteinizing hormone (LH) and testosterone were monitored. Irradiation had no effect on body weight, whereas testicular and epididymal weight began to decrease following 35 and 50 days of irradiation at 7 and 12 cGy, respectively. At 7 cGy the target cells of the gamma-rays were essentially A spermatogonia, whereas at 12 cGy A spermatogonia and preleptotene spermatocytes were primarily affected. This resulted in a progressive and sequential dose-related reduction in the number of pachytene spermatocytes, round spermatids and late spermatids (LS). Under both irradiation procedures the Sertoli cell number remained unchanged whereas partial (7 cGy) or no change (12 cGy) was seen at the Leydig cell level. Whatever the irradiation protocol, from the time LS numbers decreased, vacuolisation of the Sertoli cell cytoplasm progressively occurred, followed by thickening and folding of the peritubular tissue. Moreover, in parallel to the drop in the number of these germ cell types, ABP production fell whereas FSH levels rose. A highly significant positive correlation was found between LS numbers and these Sertoli cell parameters. This study supports our previous concept of a control of certain important aspects of Sertoli cell function by late spermatids in the adult rat.

  11. Lymphoid cell kinetics under continuous low dose-rate gamma irradiation: A comparison study

    NASA Technical Reports Server (NTRS)

    Foster, B. R.

    1975-01-01

    A comparison study was conducted of the effects of continuous low dose-rate gamma irradiation on cell population kinetics of lymphoid tissue (white pulp) of the mouse spleen with findings as they relate to the mouse thymus. Experimental techniques employed included autoradiography and specific labeling with tritiated thymidine (TdR-(h-3)). The problem studied involved the mechanism of cell proliferation of lymphoid tissue of the mouse spleen and thymus under the stress of continuous irradiation at a dose rate of 10 roentgens (R) per day for 105 days (15 weeks). The aim was to determine whether or not a steady state or near-steady state of cell population could be established for this period of time, and what compensatory mechanisms of cell population were involved.

  12. Modification of the effects of continuous low dose rate irradiation by concurrent chemotherapy infusion

    SciTech Connect

    Fu, K.K.; Rayner, P.A.; Lam, K.N.

    1984-08-01

    The combined effects of continuous low dose rate irradiation (CLDRI) and concurrent infusion of bleomycin, cyclophosphamide, cis-platinum, 5-fluorouracil, actinomycin D, and mitomycin C were studied in the SCC VII/SF tumor, a squamous cell carcinoma and the jejunal crypt cells in the mouse. For the SCC VII/SF tumor, enhanced cell killing was seen with each of the six drugs when infused concurrently with CLDRI; the greatest enhancement was seen with mitomycin C and cis-platinum. For the jejunal crypt cells, enhanced cell killing was seen primarily with bleomycin. The authors results suggest a therapeutic gain with concurrent CLDRI and chemotherapy infusion for five of the six chemotherapeutic drugs studied with the exception of bleomycin.

  13. Induction of rhodanese, a detoxification enzyme, in livers from mice after long-term irradiation with low-dose-rate gamma-rays.

    PubMed

    Nakajima, Tetsuo; Taki, Keiko; Wang, Bing; Ono, Tetsuya; Matsumoto, Tsuneya; Oghiso, Yoichi; Tanaka, Kimio; Ichinohe, Kazuaki; Nakamura, Shingo; Tanaka, Satoshi; Nenoi, Mitsuru

    2008-11-01

    The health effects of low-dose radiation exposure are of public concern. Although molecular events in the cellular response to high-dose-rate radiation exposure have been fully investigated, effects of long-term exposure to extremely low-dose-rate radiation remain unclear. Protein expression was analyzed by two-dimensional electrophoresis in livers from mice irradiated for 485 days (22 hr/day) at low-dose-rates of 0.032 microGy/min, 0.65 microGy/min and 13 microGy/min (total doses of 21 mGy, 420 mGy and 8000 mGy, respectively). One of the proteins that showed marked changes in expression was identified as rhodanese (thiosulfate sulfurtransferase). Rhodanese expression was increased after irradiation at 0.65 microGy/min and 13 microGy/min, while its expression was not changed at 0.032 microGy/min. Rhodanese is a detoxification enzyme, probably related to the regulation of antioxidative function. However, antioxidative proteins, such as superoxide dismutase (SOD)1 (also known as Cu,Zn-SOD) and SOD2 (also known as Mn-SOD), which can be induced by high-dose-rate radiation, were not induced at any low-dose-rates tested. These findings indicate that rhodanese is a novel protein induced by low-dose-rate radiation, and further analysis could provide insight into the effects of extremely low-dose-rate radiation exposure.

  14. Continuous Low-dose-rate Irradiation of Iodine-125 Seeds Inhibiting Perineural Invasion in Pancreatic Cancer

    PubMed Central

    Lu, Zheng; Dong, Teng-Hui; Si, Pei-Ren; Shen, Wei; Bi, Yi-Liang; Min, Min; Chen, Xin; Liu, Yan

    2016-01-01

    Background: Perineural invasion (PNI) is a histopathological characteristic of pancreatic cancer (PanCa). The aim of this study was to observe the treatment effect of continuous low-dose-rate (CLDR) irradiation to PNI and assess the PNI-related pain relief caused by iodine-125 (125I) seed implantation. Methods: The in vitro PNI model established by co-culture with dorsal root ganglion (DRG) and cancer cells was interfered under 2 and 4 Gy of 125I seeds CLDR irradiation. The orthotopic models of PNI were established, and 125I seeds were implanted in tumor. The PNI-related molecules were analyzed. In 30 patients with panCa, the pain relief was assessed using a visual analog scale (VAS). Pain intensity was measured before and 1 week, 2 weeks, and 1, 3, and 6 months after 125I seed implantation. Results: The co-culture of DRG and PanCa cells could promote the growth of PanCa cells and DRG neurites. In co-culture groups, the increased number of DRG neurites and pancreatic cells in radiation group was significantly less. In orthotopic models, the PNI-positive rate in radiation and control group was 3/11 and 7/11; meanwhile, the degrees of PNI between radiation and control groups was significant difference (P < 0.05). At week 2, the mean VAS pain score in patients decreased by 50% and significantly improved than the score at baseline (P < 0.05). The pain scores were lower in all patients, and the pain-relieving effect was retained about 3 months. Conclusions: The CLDR irradiation could inhibit PNI of PanCa with the value of further study. The CLDR irradiation could do great favor in preventing local recurrence and alleviating pain. PMID:27748339

  15. Tumor cure studies on the rat sarcoma BA1112 using continuous low-dose-rate radiation

    SciTech Connect

    Peschel, R.E.; Martin, D.F.; Fischer, J.J.

    1984-09-01

    Delivery of continous low-dose-rate radiation at a constant rate using an afterloading plastic helmet system can achieve the local cure of the BA1112 rat sarcoma. Complete dose response curves for local tumor cure have been obtained at 170 rad (1.7 Gy) and 130 rad (1.3 Gy) per hour. The results are consistent with the known radiobiological properties of the BA1112 tumor.

  16. Repair of I-SceI induced DSB at a specific site of chromosome in human cells: influence of low-dose, low-dose-rate gamma-rays.

    PubMed

    Yatagai, Fumio; Suzuki, Masao; Ishioka, Noriaki; Ohmori, Hitoshi; Honma, Masamitsu

    2008-11-01

    We investigated the influence of low-dose, low-dose-rate gamma-ray irradiation on DNA double strand break (DSB) repair in human lymphoblastoid TK6 cells. A single DSB was introduced at intron 4 of the TK+ allele (chromosome 17) by transfection with the I-SceI expression vector pCBASce. We assessed for DSB repair due to non-homologous end-joining (NHEJ) by determining the generation of TK-deficient mutants in the TK6 derivative TSCE5 (TK +/-) carrying an I-SceI recognition site. We similarly estimated DSB repair via homologous recombination (HR) at the same site in the derived compound heterozygote (TK-/-) cell line TSCER2 that carries an additional point mutation in exon 5. The NHEJ repair of DSB was barely influenced by pre-irradiation of the cells with 30 mGy gamma-rays at 1.2 mGy h(-1). DSB repair by HR, in contrast, was enhanced by approximately 50% after pre-irradiation of the cells under these conditions. Furthermore, when I-SceI digestion was followed by irradiation at a dose of 8.5 mGy, delivered at a dose rate of only 0.125 mGy h(-1), HR repair efficiency was enhanced by approximately 80%. This experimental approach can be applied to characterize DSB repair in the low-dose region of ionizing radiation.

  17. Lymphoid cell kinetics under continuous low dose-rate gamma irradiation: A comparison study

    NASA Technical Reports Server (NTRS)

    Foster, B. R.

    1975-01-01

    The mechanism of cell proliferation is studied in the lymphoid tissue of the mouse spleen under the stress of continuous irradiation at a dose-rate of 10 roentgens per day for 105 days. Autoradiography and specific labeling with tritiated thymidine were utilized. It was found that at least four compensatory mechanisms maintained a near-steady state of cellular growth: (1) an increase in the proportion of PAS-positive cells which stimulate mitotic activity, (2) maturation arrest of proliferating and differentiating cells which tend to replenish the cells damaged or destroyed by irradiation, (3) an increase in the proportion of cells proliferating, and (4) an increase in the proportion of precursor cells. The results are compared to previous findings observed in the thymus.

  18. The effect of continuous low dose-rate gamma irradiation on cell population kinetics of lymphoid tissue

    NASA Technical Reports Server (NTRS)

    Foster, B. R.

    1974-01-01

    Cellular response and cell population kinetics were studied during lymphopoiesis in the thymus of the mouse under continuous gamma irradiation using autoradiographic techniques and specific labeling with tritiated thymidine. On the basis of tissue weights, it is concluded that the response of both the thymus and spleen to continuous low dose-rate irradiation is multiphasic. That is, alternating periods of steady state growth, followed by collapse, which in turn is followed by another period of homeostasis. Since there are two populations of lymphocytes - short lived and long-lived, it may be that different phases of steady state growth are mediated by different lymphocytes. The spleen is affected to a greater extent with shorter periods of steady-state growth than exhibited by the thymus.

  19. Bystander Effects Induced by Continuous Low-Dose-Rate {sup 125}I Seeds Potentiate the Killing Action of Irradiation on Human Lung Cancer Cells In Vitro

    SciTech Connect

    Chen, H.H. Jia, R.F.; Yu, L.; Zhao, M.J.; Shao, C.L.; Cheng, W.Y.

    2008-12-01

    Purpose: To investigate bystander effects of low-dose-rate (LDR) {sup 125}I seed irradiation on human lung cancer cells in vitro. Methods and Materials: A549 and NCI-H446 cell lines of differing radiosensitivity were directly exposed to LDR {sup 125}I seeds irradiation for 2 or 4 Gy and then cocultured with nonirradiated cells for 24 hours. Induction of micronucleus (MN), {gamma}H2AX foci, and apoptosis were assayed. Results: After 2 and 4 Gy irradiation, micronucleus formation rate (MFR) and apoptotic rate of A549 and NCI-H446 cells were increased, and the MFR and apoptotic rate of NCI-H446 cells was 2.1-2.8 times higher than that of A549 cells. After coculturing nonirradiated bystander cells with {sup 125}I seed irradiated cells for 24 hours, MFR and the mean number of {gamma}H2AX foci/cells of bystander A549 and NCI-H446 cells were similar and significantly higher than those of control (p <0.05), although they did not increase with irradiation dose. However, the proportion of bystander NCI-H446 cells with MN numbers {>=}3 and {gamma}H2AX foci numbers 15-19 and 20-24 was higher than that of bystander A549 cells. In addition, dimethyl sulfoxide (DMSO) treatment could completely suppress the bystander MN of NCI-H446 cells, but it suppressed only partly the bystander MN of A549 cells, indicating that reactive oxygen species are involved in the bystander response to NCI-H446 cells, but other signaling factors may contribute to the bystander response of A549 cells. Conclusions: Continuous LDR irradiation of {sup 125}I seeds could induce bystander effects, which potentiate the killing action on tumor cells and compensate for the influence of nonuniform distribution of radiation dosage on therapeutic outcomes.

  20. IUdR polymers for combined continuous low-dose rate and high-dose rate sensitization of experimental human malignant gliomas.

    PubMed

    Yuan, X; Dillehay, L E; Williams, J R; Shastri, V R; Williams, J A

    2001-04-20

    Local polymeric delivery enhances IUdR radiosensitization of human malignant gliomas (MG). The combined low-dose rate (LDR) (0.03 Gy/h) and fractionated high-dose rate (HDR) treatments result in cures of experimental MGs. To enhance efficacy, we combined polymeric IUdR delivery, LDR, and HDR for treatments of both subcutaneous and intracranial MGs. In vitro: Cells (U251 MG) were trypsinized and replated in triplicate 1 day prior to LDR irradiation in media either without (control) or with 10 microM IUdR. After 72 hr, LDR irradiation cells were acutely irradiated (1.1 Gy/min) with increasing (0, 1.25, 2.5, 5.0, or 10 Gy) single doses. Implantable IUdR polymers [(poly(bis(p-carboxyphenoxy)-propane) (PCPP): sebaic acid (PCPP:SA), 20:80] (50% loading; 10 mg) were synthesized. In vivo: For flank vs. intracranial tumors, mice had 6 x 10(6) subcutaneous vs. 2 x 10(5) intracranial cells. For intracranial or subcutaneous MGs, mice had intratumoral blank (empty) vs. IUdR polymer treatments. One day after implantation, mice had immediate external LDR (3 cGy/h x 3 days total body irradiation) or HDR (2 Gy BID x 4 days to tumor site) or concurrent treatments. For the in vitro IUdR treatments, LDR resulted in a striking increase in cell-killing when combined with HDR. For the in vivo LDR treatments of flank tumors, the growth delay was greater for the IUdR vs. blank polymer treatments. For the combined LDR and HDR, the IUdR treatments resulted in a dramatic decrease in tumor volumes. On day 60 the log V/V0 were -1.7 +/- 0.22 for combined LDR + HDR + IUdR polymer (P < 0.05 vs. combined LDR + HDR + blank polymer). Survival for the intracranial controls was 22.9 +/- 1.2 days. For the blank polymer + LDR vs. blank polymer + LDR + HDR treatments, survival was 25.3 +/- 1.7 (P = NS) vs. 48.1 +/- 3.5 days (P < 0.05). For IUdR polymer + LDR treatment survival was 27.3 +/- 2.3 days (P = NS). The most striking improvement in survival followed the IUdR polymer + LDR + HDR treatment: 66

  1. Enhanced Low Dose Rate Sensitivity at Ultra-Low Dose Rates

    NASA Technical Reports Server (NTRS)

    Chen, Dakai; Pease, Ronald; Forney, James; Carts, Martin; Phan, Anthony; Cox, Stephen; Kruckmeyer, Kriby; Burns, Sam; Albarian, Rafi; Holcombe, Bruce; Little, Bradley; Salzman, James; Chaumont, Geraldine; Duperray, Herve; Ouellet, Al; Buchner, Stephen; LaBel, Kenneth

    2011-01-01

    We have presented results of ultra-low dose rate irradiations (< or = 10 mrad(Si)/s) for a variety of radiation hardened and commercial linear bipolar devices. We observed low dose rate enhancement factors exceeding 1.5 in several parts. The worst case of dose rate enhancement resulted in functional failures, which occurred after 10 and 60 krad(Si), for devices irradiated at 0.5 and 10 mrad(Si)/s, respectively. Devices fabricated with radiation hardened processes and designs also displayed dose rate enhancement at below 10 mrad(Si)/s. Furthermore, the data indicated that these devices have not reached the damage saturation point. Therefore the degradation will likely continue to increase with increasing total dose, and the low dose rate enhancement will further magnify. The cases presented here, in addition to previous examples, illustrate the significance and pervasiveness of low dose rate enhancement at dose rates lower than 10 mrad(Si). These results present further challenges for radiation hardness assurance of bipolar linear circuits, and raise the question of whether the current standard test dose rate is conservative enough to bound degradations due to ELDRS.

  2. Radiation Leukemogenesis at Low Dose Rates

    SciTech Connect

    Weil, Michael; Ullrich, Robert

    2013-09-25

    The major goals of this program were to study the efficacy of low dose rate radiation exposures for the induction of acute myeloid leukemia (AML) and to characterize the leukemias that are caused by radiation exposures at low dose rate. An irradiator facility was designed and constructed that allows large numbers of mice to be irradiated at low dose rates for protracted periods (up to their life span). To the best of our knowledge this facility is unique in the US and it was subsequently used to study radioprotectors being developed for radiological defense (PLoS One. 7(3), e33044, 2012) and is currently being used to study the role of genetic background in susceptibility to radiation-induced lung cancer. One result of the irradiation was expected; low dose rate exposures are ineffective in inducing AML. However, another result was completely unexpected; the irradiated mice had a very high incidence of hepatocellular carcinoma (HCC), approximately 50%. It was unexpected because acute exposures are ineffective in increasing HCC incidence above background. This is a potential important finding for setting exposure limits because it supports the concept of an 'inverse dose rate effect' for some tumor types. That is, for the development of some tumor types low dose rate exposures carry greater risks than acute exposures.

  3. Nuclear Material Accountability Applications of a Continuous Energy and Direction Gamma Ray Detector

    SciTech Connect

    David Gerts; Robert Bean; Marc Paff

    2010-07-01

    The Idaho National Laboratory has recently developed a detector system based on the principle of a Wilson cloud chamber that gives the original energy and direction to a gamma ray source. This detector has the properties that the energy resolution is continuous and the direction to the source can be resolved to desired fidelity. Furthermore, the detector has low power requirements, is durable, operates in widely varying environments, and is relatively cheap to produce. This detector is expected, however, to require significant time to perform measurements. To mitigate the significant time for measurements, the detector is expected to scale to very large sizes with a linear increase in cost. For example, the proof of principle detector is approximately 30,000 cm3. This work describes the technical results that lead to these assertions. Finally, the applications of this detector are described in the context of nuclear material accountability.

  4. The Universe in Gamma Rays

    NASA Astrophysics Data System (ADS)

    Schönfelder, Volker

    After describing cosmic gamma-ray production and absorption, the instrumentation used in gamma-ray astronomy is explained. The main part of the book deals with astronomical results, including the somewhat surprising result that the gamma-ray sky is continuously changing.

  5. Cell death (apoptosis) in mouse intestine after continuous irradiation with gamma rays and with beta rays from tritiated water

    SciTech Connect

    Ijiri, K.

    1989-04-01

    Apoptosis is a pattern of cell death involving nuclear pycnosis, cytoplasmic condensation, and karyorrhexis. Apoptosis induced by continuous irradiation with gamma rays (externally given by a 137Cs source) or with beta rays (from tritiated water injected ip) was quantified in the crypts of two portions of mouse bowel, the small intestine and descending colon. The time-course change in the incidence of apoptosis after each type of radiation could be explained on the basis of the innate circadian rhythm of the cells susceptible to apoptotic death and of the excretion of tritiated water (HTO) from the body. For 6-h continuous gamma irradiation at various dose rates (0.6-480 mGy/h) and for 6 h after injection of HTO of various radioactivities (0.15-150 GBq per kg body wt), the relationships between dose and incidence of apoptosis were obtained. Survival curves were then constructed from the curves for dose vs incidence of apoptosis. For the calculation of the absorbed dose from HTO, the water content both of the mouse body and of the cells was assumed to be 70%. One megabecquerel of HTO per mouse (i.e., 40 MBq/kg body wt) gave a dose rate of 0.131 mGy/h. The mean lethal doses (D0) were calculated for gamma rays and HTO, and relative biological effectiveness values of HTO relative to gamma rays were obtained. The D0 values for continuous irradiation with gamma rays were 210 mGy for small intestine and 380 mGy for descending colon, and the respective values for HTO were 130 and 280 mGy, indicating the high radiosensitivity of target cells for apoptotic death. The relative biological effectiveness of HTO relative to 137Cs gamma rays for cell killing in both the small intestine and the descending colon in the mouse was 1.4-2.1.

  6. Fermi LAT detection of a continuing increase of gamma-ray activity of CTA 102

    NASA Astrophysics Data System (ADS)

    Orienti, M.; D'Ammando, F.

    2012-09-01

    The Large Area Telescope (LAT), on board the Fermi Gamma-ray Space Telescope, has observed gamma-ray flaring activity from a source positionally consistent with the flat spectrum radio quasar CTA 102 (also known as 2FGL J2232.4+1143, Nolan et al. 2012, ApJS, 199, 31) with radio coordinates R.A.: 338.1517038 deg, Dec: 11.7308067 deg (J2000, Johnston et al. 1995, AJ, 110, 880) at redshift z=1.037 (Schmidt 1965, ApJ, 141, 1295).

  7. Continuous measurement of radionuclide distribution off Fukushima using a towed sea-bed gamma ray spectrometer

    NASA Astrophysics Data System (ADS)

    Thornton, Blair; Ohnishi, Seiki; Ura, Tamaki; Odano, Naoteru; Fujita, Tsuneo

    2013-09-01

    Instrumentation and data processing methods to continuously map the distribution of radionuclides on the seafloor have been developed and applied to survey radioactive discharge from the Fukushima Dai-ichi Nuclear Power Plant following the M9.0 earthquake and tsunami that struck the east coast of Japan on March 11 2011. The instrument consists of a flexible rubber hose with an integrated gamma ray spectrometer that measures the full gamma spectrum between 0.1 and 1.8 MeV while being towed along the seafloor by a ship. The data processing methods described allow for quantification of 137Cs and 134Cs concentration in marine sediments, and a technique has been developed to optimize the spatial resolution of the measurements for each radioactive species for a given level of statistical uncertainty. The system was deployed during August and November 2012 to measure the distribution of radionuclides along three transects within an 80 km radius of the plant. Increased levels of 137Cs and 134Cs were recorded and their distributions mapped continuously over distances of 1.6, 12.5 and 22 km respectively. The levels of 137Cs and 134Cs were found to vary significantly with location. The in situ measurements show good agreement with laboratory analyzed samples obtained during the surveys. The results demonstrate that the instrument and data processing techniques described enable high resolution, quantitative measurements of 137Cs and 134Cs in marine sediments, and provide an effective solution for rapid, low cost monitoring of radioactive material on the seafloor.

  8. Advanced Computational Approaches for Characterizing Stochastic Cellular Responses to Low Dose, Low Dose Rate Exposures

    SciTech Connect

    Scott, Bobby, R., Ph.D.

    2003-06-27

    applications of NEOTRANS2, indicate that nonlinear threshold-type, dose-response relationships for excess stochastic effects (problematic nonlethal mutations, neoplastic transformation) should be expected after exposure to low linear energy transfer (LET) gamma rays or gamma rays in combination with high-LET alpha radiation. Similar thresholds are expected for low-dose-rate low-LET beta irradiation. We attribute the thresholds to low-dose, low-LET radiation induced protection against spontaneous mutations and neoplastic transformations. The protection is presumed mainly to involve selective elimination of problematic cells via apoptosis. Low-dose, low-LET radiation is presumed to trigger wide-area cell signaling, which in turn leads to problematic bystander cells (e.g., mutants, neoplastically transformed cells) selectively undergoing apoptosis. Thus, this protective bystander effect leads to selective elimination of problematic cells (a tissue cleansing process in vivo). However, this protective bystander effects is a different process from low-dose stimulation of the immune system. Low-dose, low-LET radiation stimulation of the immune system may explain why thresholds for inducing excess cancer appear much larger (possibly more than 100-fold larger) than thresholds for inducing excess mutations and neoplastic transformations, when the dose rate is low. For ionizing radiation, the current risk assessment paradigm is such that the relative risk (RR) is always ¡Ý 1, no matter how small the dose. Our research results indicate that for low-dose or low-dose-rate, low-LET irradiation, RR < 1 may be more the rule than the exception. Directly tied to the current RR paradigm are the billion-dollar cleanup costs for radionuclide-contaminated DOE sites. Our research results suggest that continued use of the current RR paradigm for which RR ¡Ý 1 could cause more harm than benefit to society (e.g., by spreading unwarranted fear about phantom excess risks associated with low-dose low

  9. The Gamma Ray Observatory

    NASA Technical Reports Server (NTRS)

    Kniffen, Donald A.

    1991-01-01

    The Gamma Ray Observatory (GRO), scheduled for launch by the Space Shuttle in April 1991, weighs 35,000 lbs and will offer 10 to 20 times better sensitivity than any previous gamma ray mission. The four instruments aboard GRO are described. The Burst and Transient Source Experiment (BATSE) will continuously monitor the entire sky for transient gamma-ray events using eight identical, wide-field detectors capable of measuring brightness variations lasting only milliseconds at energies from about 50,000 to 600,000 eV. The Oriented Scintillation Spectrometer Experiment (OSSE) will make comprehensive observations of discrete sources at energies from 100,000 to 10 million eV, where many radioactive elements have emission lines. The observatory's Imaging Compton Telescope will conduct a deep survey of the entire sky at gamma-ray energies between 1 and 30 MeV. The Energetic Gamma Ray Experiment Telescope will cover a broad high-energy spectral range, from about 20 million to 30 billion eV and conduct a sensitive all-sky survey with a wide field of view and good angular resolution.

  10. A Search for Nontriggered Gamma-Ray Bursts in the BATSE Continuous Records: First Results

    NASA Astrophysics Data System (ADS)

    Stern, B. E.; Tikhomirova, Ya.; Stepanov, M.; Kompaneets, D.; Berezhnoy, A.; Svensson, R.

    2000-09-01

    An off-line scan for nontriggered gamma-ray bursts (GRBs) in the BATSE daily records at 1024 ms time resolution covering about 7 yr of observations gave 1353 nontriggered and 1581 triggered GRBs. The scan efficiency was measured by adding artificial test bursts to the data. The logN-logP distribution could be extended down to peak fluxes, P~0.1 photons cm-2 s-1. Previous indications of a turnover at small P are not confirmed. The logN-logP distribution cannot be fitted with a standard candle model with a nonevolving GRB source population, assuming that there are no large non-GRB contaminations. It is likely that the intrinsic luminosity function of GRBs is wide.

  11. Gamma Ray Astronomy

    NASA Technical Reports Server (NTRS)

    Wu, S. T.

    2000-01-01

    The project has progressed successfully during this period of performance. The highlights of the Gamma Ray Astronomy teams efforts are: (1) Support daily BATSE data operations, including receipt, archival and dissemination of data, quick-look science analysis, rapid gamma-ray burst and transient monitoring and response efforts, instrument state-of-health monitoring, and instrument commanding and configuration; (2) On-going scientific analysis, including production and maintenance of gamma-ray burst, pulsed source and occultation source catalogs, gamma-ray burst spectroscopy, studies of the properties of pulsars and black holes, and long-term monitoring of hard x-ray sources; (3) Maintenance and continuous improvement of BATSE instrument response and calibration data bases; (4) Investigation of the use of solid state detectors for eventual application and instrument to perform all sky monitoring of X-Ray and Gamma sources with high sensitivity; and (5) Support of BATSE outreach activities, including seminars, colloquia and World Wide Web pages. The highlights of this efforts can be summarized in the publications and presentation list.

  12. Response of human fibroblasts to low dose rate gamma irradiation

    SciTech Connect

    Dritschilo, A.; Brennan, T.; Weichselbaum, R.R.; Mossman, K.L.

    1984-11-01

    Cells from 11 human strains, including fibroblasts from patients with the genetic diseases of ataxia telangiectasia (AT), xeroderma pigmentosum (XP), and Fanconi's anemia (FA), were exposed to ..gamma.. radiation at high (1.6-2.2 Gy/min) and at low (0.03-0.07 Gy/min) dose rates. Survival curves reveal an increase inthe terminal slope (D/sub 0/) when cells are irradiated at low dose rates compared to high dose rates. This was true for all cell lines tested, although the AT, FA, and XP cells are reported or postulated to have radiation repair deficiencies. From the response of these cells, it is apparent that radiation sensitivities differ; however, at low dose rate, all tested human cells are able to repair injury.

  13. Patient release criteria for low dose rate brachytherapy implants.

    PubMed

    Boyce, Dale E; Sheetz, Michael A

    2013-04-01

    A lack of consensus regarding a model governing the release of patients following sealed source brachytherapy has led to a set of patient release policies that vary from institution to institution. The U.S. Nuclear Regulatory Commission has issued regulatory guidance on patient release in NUREG 1556, Volume 9, Rev. 2, Appendix U, which allows calculation of release limits following implant brachytherapy. While the formalism presented in NUREG is meaningful for the calculation of release limits in the context of relatively high energy gamma emitters, it does not estimate accurately the effective dose equivalent for the common low dose rate brachytherapy sources Cs, I, and Pd. NUREG 1556 states that patient release may be based on patient-specific calculations as long as the calculation is documented. This work is intended to provide a format for patient-specific calculations to be used for the consideration of patients' release following the implantation of certain low dose rate brachytherapy isotopes.

  14. Optimized source selection for intracavitary low dose rate brachytherapy

    SciTech Connect

    Nurushev, T.; Kim, Jinkoo

    2005-05-01

    A procedure has been developed for automating optimal selection of sources from an available inventory for the low dose rate brachytherapy, as a replacement for the conventional trial-and-error approach. The method of optimized constrained ratios was applied for clinical source selection for intracavitary Cs-137 implants using Varian BRACHYVISION software as initial interface. However, this method can be easily extended to another system with isodose scaling and shaping capabilities. Our procedure provides optimal source selection results independent of the user experience and in a short amount of time. This method also generates statistics on frequently requested ideal source strengths aiding in ordering of clinically relevant sources.

  15. Influence of A Continuous Very Low Dose of Gamma-Rays on Cell Proliferation, Apoptosis and Oxidative Stress

    PubMed Central

    Jozan, Suzanne; Pereda, Veronica; Courtade-Saïdi, Monique

    2015-01-01

    We have previously shown a delay of death by lymphoma in SJL/J mice irradiated with continuous very low doses of ionizing radiation. In order to understand the mechanisms involved in this phenomenon, we have irradiated in vitro the Raw264.7 monocytic and the YAC-1 lymphoma cell lines at very low-dose rate of 4cGy.month-1. We have observed a transient increase in production of both free radicals and nitric oxide with a transient adaptive response during at least two weeks after the beginning of the irradiation. The slight decrease of Ki67 proliferation index observed during the second and third weeks of YAC-1 cells culture under irradiation was not significant but consistent with the shift of the proliferation assay curves of YAC-1cells at these same durations of culture. These in vitro results were in good agreement with the slightly decrease under irradiation of Ki67 proliferative index evaluated on lymphomatous lymph nodes of SJL/J mice. A significant decrease of YAC-1 cells apoptotic rate under radiation appeared after 4 weeks of culture. Therefore very small doses of gamma-irradiation are able to modify the cellular response. The main observations did not last with increasing time under irradiation, suggesting a transient adaptation of cells or organisms to this level of irradiation. PMID:26692019

  16. Gamma ray generator

    SciTech Connect

    Firestone, Richard B; Reijonen, Jani

    2014-05-27

    An embodiment of a gamma ray generator includes a neutron generator and a moderator. The moderator is coupled to the neutron generator. The moderator includes a neutron capture material. In operation, the neutron generator produces neutrons and the neutron capture material captures at least some of the neutrons to produces gamma rays. An application of the gamma ray generator is as a source of gamma rays for calibration of gamma ray detectors.

  17. The Effects of ELDRS at Ultra-Low Dose Rates

    NASA Technical Reports Server (NTRS)

    Chen, Dakai; Forney, James; Carts, Martin; Phan, Anthony; Pease, Ronald; Kruckmeyer, Kirby; Cox, Stephen; LaBel, Kenneth; Burns, Samuel; Albarian, Rafi; Holcombe, Bruce; Little, Bradley; Salzman, James; Chaumont, Geraldine; Duperray, Herve; Ouellet, Al

    2011-01-01

    We present results on the effects on ELDRS at dose rates of 10, 5, 1, and 0.5 mrad(Si)/s for a variety of radiation hardened and commercial devices. We observed low dose rate enhancement below 10 mrad(Si)/s in several different parts. The magnitudes of the dose rate effects vary. The TL750L, a commercial voltage regulator, showed dose rate dependence in the functional failures, with initial failures occurring after 10 krad(Si) for the parts irradiated at 0.5 mrad(Si)/s. The RH1021 showed an increase in low dose rate enhancement by 2x at 5 mrad(Si)/s relative to 8 mrad(Si)/s and high dose rate, and parametric failure after 100 krad(Si). Additionally the ELDRS-free devices, such as the LM158 and LM117, showed evidence of dose rate sensitivity in parametric degradations. Several other parts also displayed dose rate enhancement, with relatively lower degradations up to approx.15 to 20 krad(Si). The magnitudes of the dose rate enhancement will likely increase in significance at higher total dose levels.

  18. Acceleration of atherogenesis in ApoE−/− mice exposed to acute or low-dose-rate ionizing radiation

    PubMed Central

    Mancuso, Mariateresa; Pasquali, Emanuela; Braga-Tanaka, Ignacia; Tanaka, Satoshi; Pannicelli, Alessandro; Giardullo, Paola; Pazzaglia, Simonetta; Tapio, Soile; Atkinson, Michael J.; Saran, Anna

    2015-01-01

    There is epidemiological evidence for increased non-cancer mortality, primarily due to circulatory diseases after radiation exposure above 0.5 Sv. We evaluated the effects of chronic low-dose rate versus acute exposures in a murine model of spontaneous atherogenesis. Female ApoE−/− mice (60 days) were chronically irradiated for 300 days with gamma rays at two different dose rates (1 mGy/day; 20 mGy/day), with total accumulated doses of 0.3 or 6 Gy. For comparison, age-matched ApoE−/− females were acutely exposed to the same doses and sacrificed 300 days post-irradiation. Mice acutely exposed to 0.3 or 6 Gy showed increased atherogenesis compared to age-matched controls, and this effect was persistent. When the same doses were delivered at low dose rate over 300 days, we again observed a significant impact on global development of atherosclerosis, although at 0.3 Gy effects were limited to the descending thoracic aorta. Our data suggest that a moderate dose of 0.3 Gy can have persistent detrimental effects on the cardiovascular system, and that a high dose of 6 Gy poses high risks at both high and low dose rates. Our results were clearly nonlinear with dose, suggesting that lower doses may be more damaging than predicted by a linear dose response. PMID:26359350

  19. Radiobiological evaluation of low dose-rate prostate brachytherapy implants

    NASA Astrophysics Data System (ADS)

    Knaup, Courtney James

    Low dose-rate brachytherapy is a radiation therapy treatment for men with prostate cancer. While this treatment is common, the use of isotopes with varying dosimetric characteristics means that the prescription level and normal organ tolerances vary. Additionally, factors such as prostate edema, seed loss and seed migration may alter the dose distribution within the prostate. The goal of this work is to develop a radiobiological response tool based on spatial dose information which may be used to aid in treatment planning, post-implant evaluation and determination of the effects of prostate edema and seed migration. Aim 1: Evaluation of post-implant prostate edema and its dosimetric and biological effects. Aim 2: Incorporation of biological response to simplify post-implant evaluation. Aim 3: Incorporation of biological response to simplify treatment plan comparison. Aim 4: Radiobiologically based comparison of single and dual-isotope implants. Aim 5: Determine the dosimetric and radiobiological effects of seed disappearance and migration.

  20. Dosimetric Study of a Low-Dose-Rate Brachytherapy Source

    NASA Astrophysics Data System (ADS)

    Rodríguez-Villafuerte, M.; Arzamendi, S.; Díaz-Perches, R.

    Carcinoma of the cervix is the most common malignancy - in terms of both incidence and mortality - in Mexican women. Low dose rate (LDR) intracavitary brachytherapy is normally prescribed for the treatment of this disease to the vast majority of patients attending public hospitals in our country. However, most treatment planning systems being used in these hospitals still rely on Sievert integral dose calculations. Moreover, experimental verification of dose distributions are hardly ever done. In this work we present a dosimetric characterisation of the Amersham CDCS-J 137Cs source, an LDR brachytherapy source commonly used in Mexican hospitals. To this end a Monte Carlo simulation was developed, that includes a realistic description of the internal structure of the source embedded in a scattering medium. The Monte Carlo results were compared to experimental measurements of dose distributions. A lucite phantom with the same geometric characteristics as the one used in the simulation was built. Dose measurements were performed using thermoluminescent dosimeters together with commercial RadioChromic dye film. A comparison between our Monte Carlo simulation, the experimental data, and results reported in the literature is presented.

  1. Gamma-ray waveguides

    SciTech Connect

    Tournear, D. M.; Hoffbauer, M. A.; Akhadov, E. A.; Chen, A. T.; Pendleton, S. J.; Williamson, T. L.; Cha, K. C.; Epstein, R. I.

    2008-04-14

    We have developed an approach for gamma-ray optics using layered structures acting as planar waveguides. Experiments demonstrating channeling of 122 keV gamma rays in two prototype waveguides validate the feasibility of this technology. Gamma-ray waveguides allow one to control the direction of radiation up to a few MeV. The waveguides are conceptually similar to polycapillary optics, but can function at higher gamma-ray energies. Optics comprised of these waveguides will be able to collect radiation from small solid angles or concentrate radiation into small area detectors. Gamma-ray waveguides may find applications in medical imaging and treatment, astrophysics, and homeland security.

  2. Induction of reciprocal translocations in rhesus monkey stem-cell spermatogonia: effects of low doses and low dose rates

    SciTech Connect

    van Buul, P.P.; Richardson, J.F. Jr.; Goudzwaard, J.H.

    1986-01-01

    The induction of reciprocal translocation in rhesus monkey spermatogonial stem cells was studied following exposure to low doses of acute X rays (0.25 Gy, 300 mGy/min) or to low-dose-rate X rays (1 Gy, 2 mGy/min) and gamma rays (1 Gy, 0.2 mGy/min). The results obtained at 0.25 Gy of X rays fitted exactly the linear extrapolation down from the 0.5 and 1.0 Gy points obtained earlier. Extension of X-ray exposure reduced the yield of translocations similar to that in the mouse by about 50%. The reduction to 40% of translocation rate after chronic gamma exposure was clearly less than the value of about 80% reported for the mouse over the same range of dose rates. Differential cell killing with ensuing differential elimination of aberration-carrying cells is the most likely explanation for the differences between mouse and monkey.

  3. Towed seabed gamma ray spectrometer

    SciTech Connect

    Jones, D.G. )

    1994-08-01

    For more than 50 years, the measurement of radioactivity has been used for onshore geological surveys and in laboratories. The British Geological Survey (BGS) has extended the use of this type of equipment to the marine environment with the development of seabed gamma ray spectrometer systems. The present seabed gamma ray spectrometer, known as the Eel, has been successfully used for sediment and solid rock mapping, mineral exploration, and radioactive pollution studies. The range of applications for the system continues to expand. This paper examines the technological aspects of the Eel and some of the applications for which it has been used.

  4. Dosimetry Modeling for Focal Low-Dose-Rate Prostate Brachytherapy

    SciTech Connect

    Al-Qaisieh, Bashar; Mason, Josh; Bownes, Peter; Henry, Ann; Dickinson, Louise; Ahmed, Hashim U.; Emberton, Mark; Langley, Stephen

    2015-07-15

    Purpose: Focal brachytherapy targeted to an individual lesion(s) within the prostate may reduce side effects experienced with whole-gland brachytherapy. The outcomes of a consensus meeting on focal prostate brachytherapy were used to investigate optimal dosimetry of focal low-dose-rate (LDR) prostate brachytherapy targeted using multiparametric magnetic resonance imaging (mp-MRI) and transperineal template prostate mapping (TPM) biopsy, including the effects of random and systematic seed displacements and interseed attenuation (ISA). Methods and Materials: Nine patients were selected according to clinical characteristics and concordance of TPM and mp-MRI. Retrospectively, 3 treatment plans were analyzed for each case: whole-gland (WG), hemi-gland (hemi), and ultra-focal (UF) plans, with 145-Gy prescription dose and identical dose constraints for each plan. Plan robustness to seed displacement and ISA were assessed using Monte Carlo simulations. Results: WG plans used a mean 28 needles and 81 seeds, hemi plans used 17 needles and 56 seeds, and UF plans used 12 needles and 25 seeds. Mean D90 (minimum dose received by 90% of the target) and V100 (percentage of the target that receives 100% dose) values were 181.3 Gy and 99.8% for the prostate in WG plans, 195.7 Gy and 97.8% for the hemi-prostate in hemi plans, and 218.3 Gy and 99.8% for the focal target in UF plans. Mean urethra D10 was 205.9 Gy, 191.4 Gy, and 92.4 Gy in WG, hemi, and UF plans, respectively. Mean rectum D2 cm{sup 3} was 107.5 Gy, 77.0 Gy, and 42.7 Gy in WG, hemi, and UF plans, respectively. Focal plans were more sensitive to seed displacement errors: random shifts with a standard deviation of 4 mm reduced mean target D90 by 14.0%, 20.5%, and 32.0% for WG, hemi, and UF plans, respectively. ISA has a similar impact on dose-volume histogram parameters for all plan types. Conclusions: Treatment planning for focal LDR brachytherapy is feasible. Dose constraints are easily met with a notable

  5. Gamma ray transients

    NASA Technical Reports Server (NTRS)

    Cline, Thomas L.

    1987-01-01

    The discovery of cosmic gamma ray bursts was made with systems designed at Los Alamos Laboratory for the detection of nuclear explosions beyond the atmosphere. HELIOS-2 was the first gamma ray burst instrument launched; its initial results in 1976, seemed to deepen the mystery around gamma ray transients. Interplanetary spacecraft data were reviewed in terms of explaining the behavior and source of the transients.

  6. Effect of continuous gamma-ray exposure on performance of learned tasks and effect of subsequent fractionated exposures on blood-forming tissue

    NASA Technical Reports Server (NTRS)

    Spalding, J. F.; Holland, L. M.; Prine, J. R.; Farrer, D. N.; Braun, R. G.

    1972-01-01

    Sixteen monkeys trained to perform continuous and discrete-avoidance and fixed-ratio tasks with visual and auditory cues were performance-tested before, during, and after 10-day gamma-ray exposures totaling 0, 500, 750, and 1000 rads. Approximately 14 months after the performance-test exposures, surviving animals were exposed to 100-rad gamma-ray fractions at 56-day intervals to observe injury and recovery patterns of blood-forming tissues. The fixed-ratio, food-reward task performance showed a transient decline in all dose groups within 24 hours of the start of gamma-ray exposure, followed by recovery to normal food-consumption levels within 48 to 72 hours. Avoidance tasks were performed successfully by all groups during the 10-day exposure, but reaction times of the two higher dose-rate groups in which animals received 3 and 4 rads per hour or total doses of 750 and 1000 rads, respectively, were somewhat slower.

  7. The usefulness of a continuous administration of tirapazamine combined with reduced dose-rate irradiation using {gamma}-rays or reactor thermal neutrons.

    PubMed

    Masunaga, S; Sakurai, Y; Nagata, K; Suzuki, M; Maruhashi, A; Kinashi, Y; Nagasawa, H; Uto, Y; Hori, H; Ono, K

    2006-12-01

    We clarified the usefulness of the continuous administration of tirapazamine (TPZ) in combination with reduced dose-rate irradiation (RDRI) using gamma-rays or reactor thermal neutrons. Squamous cell carcinoma (SCC) VII tumour-bearing mice received a continuous administration of 5-bromo-2'-deoxyuridine (BrdU) to label all proliferating (P) cells. Then, they received a single intraperitoneal injection or 24 h continuous subcutaneous infusion of TPZ in combination with conventional dose-rate irradiation (CDRI) or RDRI using gamma-rays or thermal neutrons. After irradiation, the tumour cells were isolated and incubated with a cytokinesis blocker, and the micronucleus (MN) frequency in cells without BrdU labelling ( = quiescent (Q) cells) was determined using immunofluorescence staining for BrdU. The MN frequency in the total tumour cells was determined using tumours that were not pre-treated with BrdU. The sensitivity of both total and Q cells, especially of Q cells, was significantly reduced with RDRI compared with CDRI. Combination of TPZ increased the sensitivity of both populations, with a slightly more remarkable increase in Q cells. Furthermore, the continuous administration of TPZ raised the sensitivity of both total and Q cell populations, especially the former, more markedly than the single administration, whether combined with CDRI or RDRI using gamma-rays or thermal neutrons. From the viewpoint of solid tumour control as a whole, including intratumour Q-cell control, the use of TPZ, especially when administered continuously, combined with RDRI, is useful for suppressing the reduction in the sensitivity of tumour cells caused by the decrease in irradiation dose rate in vivo.

  8. Gamma-Ray Pulsars

    NASA Technical Reports Server (NTRS)

    Harding, Alice K.

    2011-01-01

    The Fermi Gamma-Ray Space Telescope has revolutionized the study of pulsar physics with the detection of over 80 gamma-ray pulsars. Several new populations have been discovered, including 24 radio quiet pulsars found through gamma-ray pulsations alone and about 20 millisecond gamma-ray pulsars. The gamma-ray pulsations from millisecond pulsars were discovered by both folding at periods of known radio millisecond pulsars or by detecting them as gamma-ray sources that are followed up by radio pulsar searches. The second method has resulted in a phenomenally successful synergy, with -35 new radio MSPs (to date) having been discovered at Fermi unidentified source locations and the gamma-ray pulsations having then been detected in a number of these using the radio timing solutions. The higher sensitivity and larger energy range of the Fermi Large Area Telescope has produced detailed energy-dependent light curves and phase-resolved spectroscopy on brighter pulsars, that have ruled out polar cap models as the major source of the emission in favor of outer magnetosphere accelerators. The large number of gamma-ray pulsars now allows for the first time meaningful population and sub-population studies that are revealing surprising properties of these fascinating sources.

  9. Gamma-ray Bursts

    NASA Astrophysics Data System (ADS)

    Kouveliotou, Chryssa; Wijers, Ralph A. M. J.; Woosley, Stan

    2012-11-01

    Prologue C. Kouveliotou, R. A . M. J. Wijers and S. E. Woosley; 1. The discovery of the gamma-ray burst phenomenon R. W. Klebesadel; 2. Instrumental principles E. E. Fenimore; 3. The BATSE era G. J. Fishman and C. A. Meegan; 4. The cosmological era L. Piro and K. Hurley; 5. The Swift era N. Gehrels and D. N. Burrows; 6. Discoveries enabled by multi-wavelength afterglow observations of gamma-ray bursts J. Greiner; 7. Prompt emission from gamma-ray bursts T. Piran, R. Sari and R. Mochkovitch; 8. Basic gamma-ray burst afterglows P. Mészáros and R. A. M. J. Wijers; 9. The GRB-supernova connection J. Hjorth and J. S. Bloom; 10. Models for gamma-ray burst progenitors and central engines S. E. Woosley; 11. Jets and gamma-ray burst unification schemes J. Granot and E. Ramirez-Ruiz; 12. High-energy cosmic rays and neutrinos E. Waxman; 13. Long gamma-ray burst host galaxies and their environments J. P. U. Fynbo, D. Malesani and P. Jakobsson; 14. Gamma-ray burst cosmology V. Bromm and A. Loeb; 15. Epilogue R. D. Blandford; Index.

  10. Gamma-ray astrophysics

    NASA Technical Reports Server (NTRS)

    Stecker, F. W. (Editor); Trombka, J. I. (Editor)

    1973-01-01

    Conference papers on gamma ray astrophysics are summarized. Data cover the energy region from about 0.3 MeV to a few hundred GeV and theoretical models of production mechanisms that give rise to both galactic and extragalactic gamma rays.

  11. Gamma ray detector shield

    DOEpatents

    Ohlinger, R.D.; Humphrey, H.W.

    1985-08-26

    A gamma ray detector shield comprised of a rigid, lead, cylindrical-shaped vessel having upper and lower portions with an pneumatically driven, sliding top assembly. Disposed inside the lead shield is a gamma ray scintillation crystal detector. Access to the gamma detector is through the sliding top assembly.

  12. Gamma ray astrophysics to the year 2000. Report of the NASA Gamma Ray Program Working Group

    NASA Technical Reports Server (NTRS)

    1988-01-01

    Important developments in gamma-ray astrophysics up to energies of 100 GeV during the last decade are reviewed. Also, the report seeks to define the major current scientific goals of the field and proposes a vigorous program to pursue them, extending to the year 2000. The goals of gamma-ray astronomy include the study of gamma rays which provide the most direct means of studying many important problems in high energy astrophysics including explosive nucleosynthesis, accelerated particle interactions and sources, and high-energy processes around compact objects. The current research program in gamma-ray astronomy in the U.S. including the space program, balloon program and foreign programs in gamma-ray astronomy is described. The high priority recommendations for future study include an Explorer-class high resolution gamma-ray spectroscopy mission and a Get Away Special cannister (GAS-can) or Scout class multiwavelength experiment for the study of gamma-ray bursts. Continuing programs include an extended Gamma Ray Observatory mission, continuation of the vigorous program of balloon observations of the nearby Supernova 1987A, augmentation of the balloon program to provide for new instruments and rapid scientific results, and continuation of support for theoretical research. Long term recommendations include new space missions using advanced detectors to better study gamma-ray sources, the development of these detectors, continued study for the assembly of large detectors in space, collaboration with the gamma-ray astronomy missions initiated by other countries, and consideration of the Space Station attached payloads for gamma-ray experiments.

  13. Gamma-ray astronomy

    NASA Technical Reports Server (NTRS)

    Ramaty, R.; Lingenfelter, R. E.

    1982-01-01

    Cosmic gamma rays, the physical processes responsible for their production and the astrophysical sites from which they were seen are reported. The bulk of the observed gamma ray emission is in the photon energy range from about 0.1 MeV to 1 GeV, where observations are carried out above the atmosphere. There are also, however, gamma ray observations at higher energies obtained by detecting the Cerenkov light produced by the high energy photons in the atmosphere. Gamma ray emission was observed from sources as close as the Sun and the Moon and as distant as the quasar 3C273, as well as from various other galactic and extragalactic sites. The radiation processes also range from the well understood, e.g. energetic particle interactions with matter, to the still incompletely researched, such as radiation transfer in optically thick electron positron plasmas in intense neutron star magnetic fields.

  14. Gamma ray astronomy

    NASA Technical Reports Server (NTRS)

    Paciesas, William S.

    1991-01-01

    Miscellaneous tasks related to the development of the Bursts and Transient Source Experiment on the Gamma Ray Observatory and to analysis of archival data from balloon flight experiments were performed. The results are summarized and relevant references are included.

  15. Effect of continuous irradiation with a very low dose of gamma rays on life span and the immune system in SJL mice prone to B-cell lymphoma.

    PubMed

    Lacoste-Collin, L; Jozan, S; Cances-Lauwers, V; Pipy, B; Gasset, G; Caratero, C; Courtade-Saïdi, M

    2007-12-01

    Ionizing radiation has been shown to have dose- and dose-rate-dependent carcinogenic effects on the hematopoietic and lymphoreticular systems. We report here that continuous exposure to a low dose of gamma rays influences the course of spontaneous B-cell lymphoma in SJL mice. We studied the biological effects of 10 cGy year(-1) gamma rays on the life span of 560 4-week-old SJL/J female mice and on various parameters of the cell-mediated immune response. Life span was slightly prolonged. The mean survival was 397 days for controls and 417 days for irradiated mice that died with lymphoma (P = 0.34). In lymph nodes and spleen, lower percentages of CD4+ and CD8+ T cells were observed in irradiated mice before 32 weeks. Interestingly, the percentages of CD49+ NK cells were increased in the spleens of irradiated mice at 28 weeks (0.61 +/- 0.08% compared to 0.43 +/- 0.12% in controls, P = 0.01) and at 32 weeks (0.62 +/- 0.24% compared to 0.33 +/- 0.09%, P = 0.02), while NK cell activity remained unchanged in exposed mice. These results provide further support for the absence of harmful effects of a continuous very low dose of radiation on life span and incidence of lymphoma in SJL mice.

  16. Gamma-Ray Telescopes

    NASA Astrophysics Data System (ADS)

    Weekes, T.; Murdin, P.

    2000-11-01

    Gamma-rays are the highest-energy photons in the ELECTROMAGNETIC SPECTRUM and their detection presents unique challenges. On one hand it is easy to detect γ-rays. The interaction cross-sections are large and above a few MeV the pair production interaction, the dominant γ-ray interaction with matter, is easily recognized. Gamma-ray detectors were far advanced when the concept of `γ-ray astronomy' ...

  17. Gamma ray optics

    SciTech Connect

    Jentschel, M.; Guenther, M. M.; Habs, D.; Thirolf, P. G.

    2012-07-09

    Via refractive or diffractive scattering one can shape {gamma} ray beams in terms of beam divergence, spot size and monochromaticity. These concepts might be particular important in combination with future highly brilliant gamma ray sources and might push the sensibility of planned experiments by several orders of magnitude. We will demonstrate the experimental feasibility of gamma ray monochromatization on a ppm level and the creation of a gamma ray beam with nanoradian divergence. The results are obtained using the inpile target position of the High Flux Reactor of the ILL Grenoble and the crystal spectrometer GAMS. Since the refractive index is believed to vanish to zero with 1/E{sup 2}, the concept of refractive optics has never been considered for gamma rays. The combination of refractive optics with monochromator crystals is proposed to be a promising design. Using the crystal spectrometer GAMS, we have measured for the first time the refractive index at energies in the energy range of 180 - 2000 keV. The results indicate a deviation from simple 1/E{sup 2} extrapolation of X-ray results towards higher energies. A first interpretation of these new results will be presented. We will discuss the consequences of these results on the construction of refractive optics such as lenses or refracting prisms for gamma rays and their combination with single crystal monochromators.

  18. The gamma-ray observatory

    NASA Technical Reports Server (NTRS)

    1991-01-01

    An overview is given of the Gamma Ray Observatory (GRO) mission. Detection of gamma rays and gamma ray sources, operations using the Space Shuttle, and instruments aboard the GRO, including the Burst and Transient Source Experiment (BATSE), the Oriented Scintillation Spectrometer Experiment (OSSE), the Imaging Compton Telescope (COMPTEL), and the Energetic Gamma Ray Experiment Telescope (EGRET) are among the topics surveyed.

  19. A continued search for transient events in the COBE DMR database simultaneous with cosmic gamma-ray bursts

    NASA Astrophysics Data System (ADS)

    Stacy, J. Gregory; Jackson, Peter D.; Bontekoe, Tj. Romke; Winkler, Christoph

    1996-08-01

    We report on the status of our ongoing project to search the database of the COBE Differential Microwave Radiometer (DMR) experiment for transient signals at microwave wavelengths simultaneous with cosmic gamma-ray bursts (GRBs). To date we have carried out a complete search of the DMR database using burst positions taken from the original BATSE 1B catalog for the eight-month period of overlap (May-December 1991) corresponding to the first public release of COBE data. We are currently repeating our original search of the COBE DMR database using the revised burst positions of the newly-released BATSE 3B catalog. Using BATSE 1B positions, at least two apparent simultaneous observations of GRBs by the COBE DMR occurred in 1991, along with a number of ``near misses'' within 30 seconds in time. At present, only upper limits to burst microwave emission are indicated. Even in the event of a non-detection of a GRB by the COBE DMR, unprecedented observational limits will still be obtained, constraining the predictions of the many theoretical models proposed to explain the origin of GRBs.

  20. Evaluation of Enhanced Low Dose Rate Sensitivity in Discrete Bipolar Junction Transistors

    NASA Technical Reports Server (NTRS)

    Chen, Dakai; Ladbury Raymond; LaBel, Kenneth; Topper, Alyson; Ladbury, Raymond; Triggs, Brian; Kazmakites, Tony

    2012-01-01

    We evaluate the low dose rate sensitivity in several families of discrete bipolar transistors across device parameter, quality assurance level, and irradiation bias configuration. The 2N2222 showed the most significant low dose rate sensitivity, with low dose rate enhancement factor of 3.91 after 100 krad(Si). The 2N2907 also showed critical degradation levels. The devices irradiated at 10 mrad(Si)/s exceeded specifications after 40 and 50 krad(Si) for the 2N2222 and 2N2907 devices, respectively.

  1. Enhanced Low Dose Rate Effects in Bipolar Circuits: A New Hardness Assurance Problem for NASA

    NASA Technical Reports Server (NTRS)

    Johnston, A.; Barnes, C.

    1995-01-01

    Many bipolar integrated circuits are much more susceptible to ionizing radiation at low dose rates than they are at high dose rates typically used for radiation parts testing. Since the low dose rate is equivalent to that seen in space, the standard lab test no longer can be considered conservative and has caused the Air Force to issue an alert. Although a reliable radiation hardness assurance test has not yet been designed, possible mechanisms for low dose rate enhancement and hardness assurance tests are discussed.

  2. Modeling Low-Dose-Rate Effects in Irradiated Bipolar-Base Oxides

    SciTech Connect

    Cirba, C.R.; Fleetwood, D.M.; Graves, R.J.; Michez, A.; Milanowski, R.J.; Saigne, F.; Schrimpf, R.D.; Witczak, S.C.

    1998-10-26

    A physical model is developed to quantify the contribution of oxide-trapped charge to enhanced low-dose-rate gain degradation in bipolar junction transistors. Multiple-trapping simulations show that space charge limited transport is partially responsible for low-dose-rate enhancement. At low dose rates, more holes are trapped near the silicon-oxide interface than at high dose rates, resulting in larger midgap voltage shifts at lower dose rates. The additional trapped charge near the interface may cause an exponential increase in excess base current, and a resultant decrease in current gain for some NPN bipolar technologies.

  3. Enhanced Low Dose Rate Effects in Bipolar Circuits: A New Hardness Assurance Problem for NASA

    NASA Technical Reports Server (NTRS)

    Johnston, A.; Barnes, C.

    1995-01-01

    Many bipolar integrated circuits are much more susceptible to ionizing radiation at low dose rates than they are at high dose rates typically used for radiation parts testing. Since the low dose rate is equivalent to that seen in space, the standard lab test no longer can be considered conservative and has caused the Air Force to issue an alert. Although a reliable radiation hardness assurance test has not yet been designed, possible mechanisms for low dose rate enhancement and hardness assurance tests are discussed.

  4. Gamma ray camera

    DOEpatents

    Perez-Mendez, V.

    1997-01-21

    A gamma ray camera is disclosed for detecting rays emanating from a radiation source such as an isotope. The gamma ray camera includes a sensor array formed of a visible light crystal for converting incident gamma rays to a plurality of corresponding visible light photons, and a photosensor array responsive to the visible light photons in order to form an electronic image of the radiation therefrom. The photosensor array is adapted to record an integrated amount of charge proportional to the incident gamma rays closest to it, and includes a transparent metallic layer, photodiode consisting of a p-i-n structure formed on one side of the transparent metallic layer, and comprising an upper p-type layer, an intermediate layer and a lower n-type layer. In the preferred mode, the scintillator crystal is composed essentially of a cesium iodide (CsI) crystal preferably doped with a predetermined amount impurity, and the p-type upper intermediate layers and said n-type layer are essentially composed of hydrogenated amorphous silicon (a-Si:H). The gamma ray camera further includes a collimator interposed between the radiation source and the sensor array, and a readout circuit formed on one side of the photosensor array. 6 figs.

  5. Gamma ray camera

    DOEpatents

    Perez-Mendez, Victor

    1997-01-01

    A gamma ray camera for detecting rays emanating from a radiation source such as an isotope. The gamma ray camera includes a sensor array formed of a visible light crystal for converting incident gamma rays to a plurality of corresponding visible light photons, and a photosensor array responsive to the visible light photons in order to form an electronic image of the radiation therefrom. The photosensor array is adapted to record an integrated amount of charge proportional to the incident gamma rays closest to it, and includes a transparent metallic layer, photodiode consisting of a p-i-n structure formed on one side of the transparent metallic layer, and comprising an upper p-type layer, an intermediate layer and a lower n-type layer. In the preferred mode, the scintillator crystal is composed essentially of a cesium iodide (CsI) crystal preferably doped with a predetermined amount impurity, and the p-type upper intermediate layers and said n-type layer are essentially composed of hydrogenated amorphous silicon (a-Si:H). The gamma ray camera further includes a collimator interposed between the radiation source and the sensor array, and a readout circuit formed on one side of the photosensor array.

  6. Enhanced charge trapping in bipolar spacer oxides during low-dose-rate irradiation

    SciTech Connect

    Fleetwood, D.M.; Reber, R.A. Jr.; Winokur, P.S.; Kosier, S.L.; Schrimpf, R.D.; Nowlin, R.N.; Pease, R.L.; DeLaus, M.

    1994-03-01

    Thermally-stimulated-current and capacitance-voltage measurements reveal enhanced hole trapping in bipolar spacer-oxide capacitors irradiated at 0 V at low dose rates. Possible mechanisms and implications for bipolar low-rate response are discussed.

  7. Gamma Ray Bursts

    NASA Technical Reports Server (NTRS)

    Gehrels, Neil; Meszaros, Peter

    2012-01-01

    Gamma-ray bursts (GRBs) are bright flashes of gamma-rays coming from the cosmos. They occur roughly once per day ,last typically lOs of seconds and are the most luminous events in the universe. More than three decades after their discovery, and after pioneering advances from space and ground experiments, they still remain mysterious. The launch of the Swift and Fermi satellites in 2004 and 2008 brought in a trove of qualitatively new data. In this review we survey the interplay between these recent observations and the theoretical models of the prompt GRB emission and the subsequent afterglows.

  8. Gamma-ray Polarimetry

    SciTech Connect

    Tajima, Hiroyasu

    2003-02-05

    An astrophysics application of a low noise Double-sided Silicon Strip Detector (DSSD) is described. A Semiconductor Multiple-Compton Telescope (SMCT) is being developed to explore the gamma-ray universe in the 0.1-20 MeV energy band. Excellent energy resolution and polarization sensitivity are key features of the SMCT. We have developed prototype modules for a low-noise DSSD system, which reached an energy resolution of 1.3 keV (FWHM) for 122 keV at 0 C. Results of a gamma-ray imaging test are also presented.

  9. Use of MOS structures for the investigation of low-dose-rate effects in bipolar transistors

    SciTech Connect

    Belyakov, V.V.; Pershenkov, V.S.; Shalnov, A.V.; Shvetzov-Shilovsky, I.N.

    1995-12-01

    A possible physical mechanism for bipolar transistor low-dose-rate irradiation response is discussed. This mechanism is described in terms of shallow electron traps in oxide. The experimental results on positive charge build-up at low dose-rates and small electric field in oxide are presented. The use of MOS transistor in bipolar mode for investigation of surface peripheral recombination current in bipolar transistor and extraction of MOS structure physical parameters is described.

  10. Celestial gamma ray study

    NASA Technical Reports Server (NTRS)

    Michelson, Peter F.

    1995-01-01

    This report documents the research activities performed by Stanford University investigators as part of the data reduction effort and overall support of the Energetic Gamma Ray Experiment Telescope (EGRET) on the Compton Observatory. This report is arranged chronologically, with each subsection detailing activities during roughly a one year period of time, beginning in June 1991.

  11. Scission gamma rays

    SciTech Connect

    Danilyan, G. V.; Klenke, J.; Krakhotin, V. A.; Kuznetsov, V. L.; Novitsky, V. V.; Pavlov, V. S.; Shatalov, P. B.

    2009-11-15

    Gamma rays probably emitted by the fissioning nucleus {sup 236}U* at the instant of the break of the neck or within the time of about 10{sup -21} s after or before this were discovered in the experiment devoted to searches for the effect of rotation of the fissioning nucleus in the process {sup 235}U(n,{gamma}f) and performed in a polarized beam of cold neutrons from the MEPHISTO Guideline at the FRM II Munich reactor. Detailed investigations revealed that the angular distribution of these gamma rays is compatible with the assumption of the dipole character of the radiation and that their energy spectrum differs substantially from the spectrum of prompt fission gamma rays. In the measured interval 250-600 keV, this spectrum can be described by an exponential function at the exponent value of {alpha} = -5 x 10{sup -3} keV{sup -1}. The mechanism of radiation of such gamma rays is not known at the present time. Theoretical models based on the phenomenon of the electric giant dipole resonance in a strongly deformed fissioning nucleus or in a fission fragment predict harder radiation whose spectrum differs substantially from the spectrum measured in the present study.

  12. Gamma ray astronomy

    NASA Technical Reports Server (NTRS)

    Paciesas, William S.

    1991-01-01

    Miscellaneous tasks related to the development of the Burst and Transient Source Experiment on the Gamma Ray Observatory and to collection, analysis, and interpretation of data from the MSFC Very Low Frequency transient monitoring program were performed. The results are summarized and relevant references are included.

  13. Gamma ray astronomy

    NASA Technical Reports Server (NTRS)

    Paciesas, William S.

    1992-01-01

    Miscellaneous tasks related to mission operations and data analysis for the Burst and Transient Source Experiment on the Gamma Ray Observatory, to collection, analysis, and interpretation of data from the Marshall Space Flight Center Very Low Frequency transient monitoring program, and to compilation and analysis of induced radioactivity data were performed. The results are summarized and relevant references are included.

  14. Gamma radiation at a human relevant low dose rate is genotoxic in mice

    NASA Astrophysics Data System (ADS)

    Graupner, Anne; Eide, Dag M.; Instanes, Christine; Andersen, Jill M.; Brede, Dag A.; Dertinger, Stephen D.; Lind, Ole C.; Brandt-Kjelsen, Anicke; Bjerke, Hans; Salbu, Brit; Oughton, Deborah; Brunborg, Gunnar; Olsen, Ann K.

    2016-09-01

    Even today, 70 years after Hiroshima and accidents like in Chernobyl and Fukushima, we still have limited knowledge about the health effects of low dose rate (LDR) radiation. Despite their human relevance after occupational and accidental exposure, only few animal studies on the genotoxic effects of chronic LDR radiation have been performed. Selenium (Se) is involved in oxidative stress defence, protecting DNA and other biomolecules from reactive oxygen species (ROS). It is hypothesised that Se deficiency, as it occurs in several parts of the world, may aggravate harmful effects of ROS-inducing stressors such as ionising radiation. We performed a study in the newly established LDR-facility Figaro on the combined effects of Se deprivation and LDR γ exposure in DNA repair knockout mice (Ogg1‑/‑) and control animals (Ogg1+/‑). Genotoxic effects were seen after continuous radiation (1.4 mGy/h) for 45 days. Chromosomal damage (micronucleus), phenotypic mutations (Pig-a gene mutation of RBCCD24‑) and DNA lesions (single strand breaks/alkali labile sites) were significantly increased in blood cells of irradiated animals, covering three types of genotoxic activity. This study demonstrates that chronic LDR γ radiation is genotoxic in an exposure scenario realistic for humans, supporting the hypothesis that even LDR γ radiation may induce cancer.

  15. Gamma radiation at a human relevant low dose rate is genotoxic in mice

    PubMed Central

    Graupner, Anne; Eide, Dag M.; Instanes, Christine; Andersen, Jill M.; Brede, Dag A.; Dertinger, Stephen D.; Lind, Ole C.; Brandt-Kjelsen, Anicke; Bjerke, Hans; Salbu, Brit; Oughton, Deborah; Brunborg, Gunnar; Olsen, Ann K.

    2016-01-01

    Even today, 70 years after Hiroshima and accidents like in Chernobyl and Fukushima, we still have limited knowledge about the health effects of low dose rate (LDR) radiation. Despite their human relevance after occupational and accidental exposure, only few animal studies on the genotoxic effects of chronic LDR radiation have been performed. Selenium (Se) is involved in oxidative stress defence, protecting DNA and other biomolecules from reactive oxygen species (ROS). It is hypothesised that Se deficiency, as it occurs in several parts of the world, may aggravate harmful effects of ROS-inducing stressors such as ionising radiation. We performed a study in the newly established LDR-facility Figaro on the combined effects of Se deprivation and LDR γ exposure in DNA repair knockout mice (Ogg1−/−) and control animals (Ogg1+/−). Genotoxic effects were seen after continuous radiation (1.4 mGy/h) for 45 days. Chromosomal damage (micronucleus), phenotypic mutations (Pig-a gene mutation of RBCCD24−) and DNA lesions (single strand breaks/alkali labile sites) were significantly increased in blood cells of irradiated animals, covering three types of genotoxic activity. This study demonstrates that chronic LDR γ radiation is genotoxic in an exposure scenario realistic for humans, supporting the hypothesis that even LDR γ radiation may induce cancer. PMID:27596356

  16. Gamma ray astronomy

    NASA Technical Reports Server (NTRS)

    Paciesas, William S.

    1994-01-01

    The Burst and Transient Source Experiment (BATSE) is one of four instruments on the Compton observatory which was launched by the space shuttle Atlantis on April 5, 1991. As of mid-March, 1994, BATSE detected more than 925 cosmic gamma-ray bursts and more than 725 solar flares. Pulsed gamma rays have been detected from at least 16 sources and emission from at least 28 sources (including most of the pulsed sources) has been detected by the earth occultation technique. UAH participation in BATSE is extensive but can be divided into two main areas, operations and data analysis. The daily BATSE operations tasks represent a substantial level of effort and involve a large team composed of MSFC personnel as well as contractors such as UAH. The scientific data reduction and analysis of BATSE data is also a substantial level of effort in which UAH personnel have made significant contributions.

  17. A Snapshot of the Continuous Emission of the Active Galactic Nucleus in NGC 3783 from Gamma-Ray to Radio Wavelengths

    NASA Technical Reports Server (NTRS)

    Alloin, D.; Santos-Lleo, M.; Peterson, B. M.; Wamsteker, W.; Altieri, B.; Brinkmann, W.; Clavel, J.; Crenshaw, D. M.; George, I. M.; Glass, I. S.; Johnson, W. N.; Kriss, G. A.; Malkan, M. A.; Polidan, R. S.; Reichert, G. A.; Rodriguez-Pascual, P. M.; Romanishin, W.; Starr, C. H.; Stirpe, G. M.; Taylor, M.; Turner, T. J.; Vega, H.; Winge, C.; Wood, D.O.S.

    1995-01-01

    To better understand the physical processes that produce the continuous emission in active galactic nuclei (AGN), a snapshot of the overall continuous energy distribution of NGC 3783, from gamma ray to radio wavelengths, has been obtained within the framework of the World Astronomy Days. The data collected in this campaign are from GRO, ROSAT, Voyager 2, IUE, HST, CTIO, SAAO, and the VLA. Great care has been taken in disentangling the genuine AGN continusous emission from other contributions; depending on the waveband, the latter might be (1) unrelated contaminating sources in cases where the instrument field of view is large (2) components within which the AGN is embedded, such as the stellar bulge population which accounts for a significant fraction of the optical continuum, and free-bound and FE2 blends wich contribute to the ultraviolet flux. After correction for these other contributins, the continuous emission of the isolated AGN appears to be rather flat (i.e., approximately equal energy per unit logarithmic frequency) from soft gamma ray to infrared wavelengths. At high energies (0.1 MeV to 0.1 keV), the AGN continuum can be fitted by a power law F nu approaches Nu(exp -a) with a spectral index of alpha approximately 1. At longer wavelengths, two excesses above this power law ('bumps') appear: in the ultraviolet, the classical big blue bump, which can be interpreted as thermal emission from the accretion disc surrounding a massive black hole, and in the infrared, a second bump which can be ascribed to thermal emission from dust in the vicinity of the AGN, heated by ultraviolet radiation from the central source. By fitting accretion-disk models to the observed AGN spectral energy distribution, we find values for the accretion disk innermost temperature, accretion rate, and black hole mass, with some differences that depend on whether or not we extrapolate the high energy power law up to infrared wavelengths. A fit to the IR bump above the extended alpha

  18. Topics in gamma ray astronomy

    NASA Technical Reports Server (NTRS)

    Ramaty, R.; Lingenfelter, R. E.

    1986-01-01

    Observations of gamma rays from solar flares, gamma ray bursts, the Galactic center, galactic nucleosynthesis, SS433, and Cygnus X-3, and their effects on astrophysical problems are discussed. It is observed that gamma ray spectra from solar flares are applicable to the study of particle acceleration and confinement and the determination of chemical abundances in the solar atmosphere. The gamma ray lines from the compact galactic object SS433 are utilized to examine the acceleration of jets, and analysis of the gamma ray lines of Cygnus X-3 reveal that particles can be accelerated in compact sources to ultrahigh energies.

  19. Topics in gamma ray astronomy

    NASA Technical Reports Server (NTRS)

    Ramaty, R.; Lingenfelter, R. E.

    1986-01-01

    Observations of gamma rays from solar flares, gamma ray bursts, the Galactic center, galactic nucleosynthesis, SS433, and Cygnus X-3, and their effects on astrophysical problems are discussed. It is observed that gamma ray spectra from solar flares are applicable to the study of particle acceleration and confinement and the determination of chemical abundances in the solar atmosphere. The gamma ray lines from the compact galactic object SS433 are utilized to examine the acceleration of jets, and analysis of the gamma ray lines of Cygnus X-3 reveal that particles can be accelerated in compact sources to ultrahigh energies.

  20. Gamma ray collimator

    NASA Technical Reports Server (NTRS)

    Casanova, Edgar J. (Inventor)

    1991-01-01

    A gamma ray collimator including a housing having first and second sections is disclosed. The first section encloses a first section of depleted uranium which is disposed for receiving and supporting a radiation emitting component such as cobalt 60. The second section encloses a depleted uranium member which is provided with a conical cut out focusing portion disposed in communication with the radiation emitting element for focusing the emitted radiation to the target.

  1. Gamma ray collimator

    NASA Technical Reports Server (NTRS)

    Casanova, Edgar J. (Inventor)

    1993-01-01

    A gamma ray collimator including a housing having first and second sections. The first section encloses a first section of depleted uranium which is disposed for receiving and supporting a radiation emitting component such as cobalt 60. The second section encloses a depleted uranium member which is provided with a conical cut-out focusing portion disposed in communication with the radiation emitting element for focusing the emitted radiation to the target.

  2. MOLE: A new high-energy gamma-ray diagnostic

    SciTech Connect

    Moran, M.J.; Chang, B.

    1992-01-21

    Continued interest in high-energy {gamma} rays associated with fusion reactions has motivated an ongoing search for simple, effective measurement techniques. Past experiments have measured 16.7-MeV {gamma} rays with Compton-magnetic spectrometers. Some measurements have been performed with threshold Cherenkov detectors with enhanced sensitivity to high-energy {gamma} rays. The Compton spectrometers work quite well, but they require extensive calibrations and tend to be expensive and cumbersome. The threshold Cherenkov detectors are simpler to calibrate and physically compact, but have poor spectral definition and are vulnerable to background signals. This report is to describe a new type of {gamma}-ray detector, the MOLE, that may retain the simplicity of a threshold Cherenkov detector while still having sufficient energy discrimination to be effective for measuring high-energy {gamma}-rays in the presence of lower-energy {gamma}-ray fluxes.

  3. UNIDENTIFIED {gamma}-RAY SOURCES: HUNTING {gamma}-RAY BLAZARS

    SciTech Connect

    Massaro, F.; Ajello, M.; D'Abrusco, R.; Paggi, A.; Tosti, G.; Gasparrini, D.

    2012-06-10

    One of the main scientific objectives of the ongoing Fermi mission is unveiling the nature of unidentified {gamma}-ray sources (UGSs). Despite the major improvements of Fermi in the localization of {gamma}-ray sources with respect to the past {gamma}-ray missions, about one-third of the Fermi-detected objects are still not associated with low-energy counterparts. Recently, using the Wide-field Infrared Survey Explorer survey, we discovered that blazars, the rarest class of active galactic nuclei and the largest population of {gamma}-ray sources, can be recognized and separated from other extragalactic sources on the basis of their infrared (IR) colors. Based on this result, we designed an association method for the {gamma}-ray sources to recognize if there is a blazar candidate within the positional uncertainty region of a generic {gamma}-ray source. With this new IR diagnostic tool, we searched for {gamma}-ray blazar candidates associated with the UGS sample of the second Fermi {gamma}-ray LAT catalog (2FGL). We found that our method associates at least one {gamma}-ray blazar candidate as a counterpart to each of 156 out of 313 UGSs analyzed. These new low-energy candidates have the same IR properties as the blazars associated with {gamma}-ray sources in the 2FGL catalog.

  4. Unidentified Gamma-Ray Sources: Hunting Gamma-Ray Blazars

    SciTech Connect

    Massaro, F.; D'Abrusco, R.; Tosti, G.; Ajello, M.; Gasparrini, A.Paggi.D.

    2012-04-02

    One of the main scientific objectives of the ongoing Fermi mission is unveiling the nature of the unidentified {gamma}-ray sources (UGSs). Despite the large improvements of Fermi in the localization of {gamma}-ray sources with respect to the past {gamma}-ray missions, about one third of the Fermi-detected objects are still not associated to low energy counterparts. Recently, using the Wide-field Infrared Survey Explorer (WISE) survey, we discovered that blazars, the rarest class of Active Galactic Nuclei and the largest population of {gamma}-ray sources, can be recognized and separated from other extragalactic sources on the basis of their infrared (IR) colors. Based on this result, we designed an association method for the {gamma}-ray sources to recognize if there is a blazar candidate within the positional uncertainty region of a generic {gamma}-ray source. With this new IR diagnostic tool, we searched for {gamma}-ray blazar candidates associated to the UGS sample of the second Fermi {gamma}-ray catalog (2FGL). We found that our method associates at least one {gamma}-ray blazar candidate as a counterpart each of 156 out of 313 UGSs analyzed. These new low-energy candidates have the same IR properties as the blazars associated to {gamma}-ray sources in the 2FGL catalog.

  5. Integration and evaluation of a position sensor with continuous read-out for use with the Environmental Measurement-While-Drilling Gamma Ray Spectrometer system

    SciTech Connect

    Normann, R.A.; Lockwood, G.J.; Williams, C.V.; Selph, M.M.

    1998-02-01

    The Environmental Measurement-While-Drilling-Gamma Ray Spectrometer (EMWD-GRS) system represents an innovative blend of new and existing technology that provides real-time environmental and drill bit data during drilling operations. The EMWD-GRS technology was demonstrated at Savannah River Site (SRS) F-Area Retention Basin. The EMWD-GRS technology demonstration consisted of continuously monitoring for gamma-radiation-producing contamination while drilling two horizontal boreholes below the backfilled waste retention basin. These boreholes passed near previously sampled locations where concentrations of contaminant levels of cesium had been measured. Contaminant levels continuously recorded by the EMWD-GRS system during drilling were compared to contaminant levels previously determined through quantitative laboratory analysis of soil samples. The results show general agreement between the soil sampling and EMWD-GRS techniques for Cs-137. The EMWD-GRS system has been improved by the integration of an orientation sensor package for position sensing (PS) (EMWD-GRS/PS). This added feature gives the capability of calculating position, which is tied directly to EMWD-GRS sensor data obtained while drilling. The EMWD-GRS/PS system is described and the results of the field tests are presented.

  6. Gamma-Ray Localization of Terrestrial Gamma-Ray Flashes

    SciTech Connect

    Marisaldi, M.; Labanti, C.; Fuschino, F.; Bulgarelli, A.; Trifoglio, M.; Di Cocco, G.; Gianotti, F.; Argan, A.; De Paris, G.; Trois, A.; Del Monte, E.; Costa, E.; Di Persio, G.; Donnarumma, I.; Evangelista, Y.; Feroci, M.; Lazzarotto, F.; Pacciani, L.; Rubini, A.; Sabatini, S.

    2010-09-17

    Terrestrial gamma-ray flashes (TGFs) are very short bursts of high-energy photons and electrons originating in Earth's atmosphere. We present here a localization study of TGFs carried out at gamma-ray energies above 20 MeV based on an innovative event selection method. We use the AGILE satellite Silicon Tracker data that for the first time have been correlated with TGFs detected by the AGILE Mini-Calorimeter. We detect 8 TGFs with gamma-ray photons of energies above 20 MeV localized by the AGILE gamma-ray imager with an accuracy of {approx}5-10 deg. at 50 MeV. Remarkably, all TGF-associated gamma rays are compatible with a terrestrial production site closer to the subsatellite point than 400 km. Considering that our gamma rays reach the AGILE satellite at 540 km altitude with limited scattering or attenuation, our measurements provide the first precise direct localization of TGFs from space.

  7. Short gamma-ray bursts: A review

    NASA Astrophysics Data System (ADS)

    D'Avanzo, P.

    2015-09-01

    Gamma-Ray Bursts (GRBs) are rapid, bright flashes of radiation peaking in the gamma-ray band occurring at an average rate of one event per day at cosmological distances. They are characterized by a collimated relativistic outflow pushing through the interstellar medium shining in gamma-rays powered by a central engine. This prompt phase is followed by a fading afterglow emission at longer wavelength, powered in part by the expanding outflow, and in part by continuous energy injection by the central engine. The observed evidences of supernovae associated to long GRBs (those with a duration of the gamma-ray emission > 2 s) brought to a general consensus on indicating the core collapse of massive stars as the progenitor of these events. Following the most accredited model, short GRBs (the events with a duration of the gamma-ray emission ≤ 2 s) originate from the coalescence of compact binary systems (two neutron stars or neutron star-black hole systems). This paper presents a review of the observational properties of short GRBs and shows how the study of these properties can be used as a tool to unveil their elusive progenitors and provide information on the nature of the central engine powering the observed emission. The increasing evidence for compact object binary progenitors makes short GRBs one of the most promising sources of gravitational waves for the forthcoming Advanced LIGO/Virgo experiments.

  8. Accelerated tests for bounding the low dose rate radiation response of lateral PNP bipolar junction transistors

    SciTech Connect

    Witczak, S.C.; Schrimpf, R.D.; Galloway, K.F.; Schmidt, D.M.; Fleetwood, D.M.; Pease, R.L.; Coombs, W.E.; Suehle, J.S.

    1996-03-01

    Low dose rate gain degradation of lateral pnp bipolar transistors can be simulated by accelerated irradiations performed at approximately 135 degrees C. Degradation enhancement is explained by temperature- dependent radiation-induced interface trap formation above the transistor`s base.

  9. Measurement bias dependence of enhanced bipolar gain degradation at low dose rates

    SciTech Connect

    Witczak, S.C.; Lacoe, R.C.; Mayer, D.C.; Schrimpf, R.D.; Barnaby, H.J.; Galloway, K.F.; Pease, R.L.; Fleetwood, D.M.

    1998-03-01

    Oxide trapped charge, field effects from emitter metallization, and high level injection phenomena moderate enhanced gain degradation of lateral pnp transistors at low dose rates. Hardness assurance tests at elevated irradiation temperatures require larger design margins for low power measurement biases.

  10. Integration and Evaluation of a Position Sensor with Continuous Read-Out for use with the Environmental Measurement-While-Drilling Gamma Ray Spectrometer System

    SciTech Connect

    Lockwood, G.J.; Normann, R.A.; Selph, M.M.; Williams, C.V.

    1999-02-22

    The Environmental Measurement-While-Drilling-Gamma Ray Spectrometer (EMWD-GRS) system represents an innovative blend of new and existing technology that provides real-time environmental and drill bit data during drilling operations. The EMWD-GRS technology was demonstrated at Savannah River Site (SRS) F-Area Retention Basin. The EMWD-GRS technology demonstration consisted of continuously monitoring for gamma-radiation-producing contamination while drilling two horizontal boreholes below the backfilled waste retention basin. These boreholes passed near previously sampled locations where concentrations of contaminant levels of cesium had been measured. Contaminant levels continuously recorded by the EMWD-GRS system during drilling were compared to contaminant levels previously determined through quantitative laboratory analysis of soil samples. The demonstration of the EMWD-GRS was a complete success. The results show general agreement between the soil sampling and EMWD-GRS techniques for CS-137. It was recognized that the EMWD-GRS tool would better satisfy our customers' needs if the instrument location could be continuously monitored. During the demonstration at SRS, an electromagnetic beacon with a walkover monitor (Subsite{reg_sign}) was used to measure bit location at depth. To use a beacon locator drilling must be stopped, thus it is normally only used when a new section of pipe was added. The location of contamination could only be estimated based on the position of the EMED-GRS package and the distance between locator beacon readings. A continuous location system that would allow us to know the location of each spectrum as it is obtained is needed.

  11. Lunar based gamma ray astronomy

    NASA Astrophysics Data System (ADS)

    Haymes, R. C.

    Gamma ray astronomy represents the study of the universe on the basis of the electromagnetic radiation with the highest energy. Gamma ray astronomy provides a crucial tool for the understanding of astronomical phenomena, taking into account nucleosynthesis in supernovae, black holes, active galaxies, quasars, the sources of cosmic rays, neutron stars, and matter-antimatter annihilation. Difficulties concerning the conduction of studies by gamma ray astronomy are related to the necessity to perform such studies far from earth because the atmosphere is a source of gamma rays. Studies involving the use of gamma ray instruments in earth orbit have been conducted, and more gamma ray astronomy observations are planned for the future. Imperfections of studies conducted in low earth orbit could be overcome by estalishing an observatory on the moon which represents a satellite orbiting at 60 earth radii. Details concerning such an observatory are discussed.

  12. Analysis of Data from the Energetic Gamma-Ray Experiment Telescope (EGRET) on the Compton Gamma Ray Observatory

    NASA Technical Reports Server (NTRS)

    Kniffen, Donald A.; Elliott, William W.

    1999-01-01

    The final report consists of summaries of work proposed, work accomplished, papers and presentations published and continuing work regarding the cooperative agreement. The work under the agreement is based on high energy gamma ray source data analysis collected from the Energetic Gamma-Ray Experiment Telescope (EGRET).

  13. Development and characterization of a novel variable low-dose rate irradiator for in vivo mouse studies

    PubMed Central

    Olipitz, Werner; Hembrador, Sheena; Davidson, Matthew; Yanch, Jacquelyn C.; Engelward, Bevin P.

    2011-01-01

    Radiation exposure of humans generally results in low doses delivered at low dose-rate. Our limited knowledge of the biological effects of low dose radiation is mainly based on data from the atomic bomb long-term survivor study (LSS) cohort. However, the total doses and dose-rates in the LSS cohort are still higher than most environmental and occupational exposures in humans. Importantly, the dose-rate is a critical determinant of health risks stemming from radiation exposure. Understanding the shape of the dose-rate response curve for different biological outcomes is thus crucial for projecting the biological hazard from radiation in different environmental and man-made conditions. A significant barrier to performing low dose-rate studies is the difficulty in creating radiation source configurations compatible with long-term cellular or animal experiments. In this study the design and characterization of a large area, 125I-based irradiator is described. The irradiator allows continuous long-term exposure of mice at variable dose-rates and can be sited in standard animal care facilities. The dose-rate is determined by the level of 125I activity added to a large NaOH filled, rectangular phantom. The desired dose rate is maintained at essentially constant levels by weekly additions of 125I to compensate for decay. Dosimetry results for long-term animal irradiation at targeted dose rates of 0.00021 and 0.0021 cGy min−1 are presented. PMID:20386202

  14. Cell cycle alterations, apoptosis, and response to low-dose-rate radioimmunotherapy in lymphoma cells

    SciTech Connect

    Macklis, R.M.; Beresford, B.A.; Palayoor, S.; Sweeney, S.; Humm, J.L.

    1993-10-20

    In an attempt to elucidate some aspects of the radiobiological basis of radioimmunotherapy, we have evaluated the in vitro cellular response patterns for malignant lymphoma cell lines exposed to high- and low-dose-rate radiation administered within the physiological context of antibody cell-surface binding. We used two different malignant lymphoma cell lines, a Thy1.2{sup +} murine T-lymphoma line called EL-4 and a CD20{sup +} human B-lymphoma line called Raji. Irradiated cells were evaluated for viability, cell-cycle changes, patterns of post-radiation morphologic changes, and biochemical hallmarks of radiation-associated necrosis and programmed cell death. The EL-4 line was sensitive to both high-dose-rate and low-dose-rate irradiation, while the Raji showed efficient cell kill only after high-dose-rate irradiation. Studies of radiation-induced cell cycle changes demonstrated that both cell lines were efficiently blocked at the G2/M interface by high-dose-rate irradiation, with the Raji cells appearing somewhat more susceptible than the EL-4 cells to low-dose-rate radiation-induced G2/M block. Electron microscopy and DNA gel electrophoresis studies showed that a significant proportion of the EL-4 cells appeared to be dying by radiation-induced programmed cell death (apoptosis) while the Raji cells appeared to be dying primarily by classical radiation-induced cellular necrosis. We propose that the unusual clinical responsiveness of some high and low grade lymphomas to modest doses of low-dose-rate radioimmunotherapy may be explained in part by the induction of apoptosis. The unusual dose-response characteristics observed in some experimental models of radiation-induced apoptosis may require a reappraisal of standard linear quadratic and alpha/beta algorithms used to predict target tissue cytoreduction after radioimmunotheraphy. 34 refs., 4 figs.

  15. Current topics in the treatment of prostate cancer with low-dose-rate brachytherapy.

    PubMed

    Stock, Richard G; Stone, Nelson N

    2010-02-01

    The treatment of prostate cancer with low dose rate prostate brachytherapy has grown rapidly in the last 20 years. Outcome analyses performed in this period have enriched understanding of this modality. This article focuses on the development of a real-time ultrasound-guided implant technique, the importance of radiation dose, trimodality treatment of high-risk disease, long-term treatment outcomes, and treatment-associated morbidity.

  16. Gamma Ray Bursts - Observations

    NASA Technical Reports Server (NTRS)

    Gehrels, N.; Cannizzo, J. K.

    2010-01-01

    We are in an exciting period of discovery for gamma-ray bursts. The Swift observatory is detecting 100 bursts per year, providing arcsecond localizations and sensitive observations of the prompt and afterglow emission. The Fermi observatory is observing 250 bursts per year with its medium-energy GRB instrument and about 10 bursts per year with its high-energy LAT instrument. In addition, rapid-response telescopes on the ground are providing new capabilities to study optical emission during the prompt phase and spectral signatures of the host galaxies. The combined data set is enabling great advances in our understanding of GRBs including afterglow physics, short burst origin, and high energy emission.

  17. Gamma-ray line astrophysics

    NASA Technical Reports Server (NTRS)

    Lingenfelter, R. E.; Ramaty, R.

    1986-01-01

    Recent observations of gamma-ray line emission from solar flares, gamma-ray bursts, the galactic center, the interstellar medium and the jets of SS433 are reviewed. The implications of these observations on high energy processes in these sources are discussed.

  18. The Compton Gamma Ray Observatory

    NASA Technical Reports Server (NTRS)

    Gehrels, N.; Chipman, E.; Kniffen, D.

    1994-01-01

    The Arthur Holly Compton Gamma Ray Observatory Compton) is the second in NASA's series of great Observatories. Launched on 1991 April 5, Compton represents a dramatic increase in capability over previous gamma-ray missions. The spacecraft and scientific instruments are all in good health, and many significant discoveries have already been made. We describe the capabilities of the four scientific instruments, and the observing program of the first 2 years of the mission. Examples of early discoveries by Compton are enumerated, including the discovery that gamma-ray bursts are isotropic but spatially inhomogeneous in their distribution; the discovery of a new class of high-energy extragalacatic gamma-ray sources, the gamma-ray AGNs; the discovery of emission from SN 1987A in the nuclear line of Co-57; and the mapping of emission from Al-26 in the interstellar medium (ISM) near the Galactic center. Future observations will include deep surveys of selected regions of the sky, long-tem studies of individual objects, correlative studies of objects at gamma-ray and other energies, a Galactic plane survey at intermediate gamma-ray energies, and improved statistics on gamma-ray bursts to search for small anisotropies. After completion of the all-sky survey, a Guest Investigator program is in progress with guest observers' time share increasing from 30% upward for the late mission phases.

  19. The Compton Gamma Ray Observatory

    NASA Astrophysics Data System (ADS)

    Gehrels, N.; Chipman, E.; Kniffen, D.

    1994-06-01

    The Arthur Holly Compton Gamma Ray Observatory Compton) is the second in NASA's series of great Observatories. Launched on 1991 April 5, Compton represents a dramatic increase in capability over previous gamma-ray missions. The spacecraft and scientific instruments are all in good health, and many significant discoveries have already been made. We describe the capabilities of the four scientific instruments, and the observing program of the first 2 years of the mission. Examples of early discoveries by Compton are enumerated, including the discovery that gamma-ray bursts are isotropic but spatially inhomogeneous in their distribution; the discovery of a new class of high-energy extragalacatic gamma-ray sources, the gamma-ray AGNs; the discovery of emission from SN 1987A in the nuclear line of Co-57; and the mapping of emission from Al-26 in the interstellar medium (ISM) near the Galactic center. Future observations will include deep surveys of selected regions of the sky, long-tem studies of individual objects, correlative studies of objects at gamma-ray and other energies, a Galactic plane survey at intermediate gamma-ray energies, and improved statistics on gamma-ray bursts to search for small anisotropies. After completion of the all-sky survey, a Guest Investigator program is in progress with guest observers' time share increasing from 30% upward for the late mission phases.

  20. Gamma-ray burst observations

    NASA Technical Reports Server (NTRS)

    Atteia, J.-L.

    1993-01-01

    The most important observational characteristics of gamma-ray bursts are reviewed, with emphasis on X-ray and gamma-ray data. The observations are used to derive some basic properties of the sources. The sources are found to be isotropically distributed; the burster population is limited in space, and the edge of the distribution is visible.

  1. Gamma Ray Pulsars: Multiwavelength Observations

    NASA Technical Reports Server (NTRS)

    Thompson, David J.

    2004-01-01

    High-energy gamma rays are a valuable tool for studying particle acceleration and radiation in the magnetospheres of energetic pulsars. The seven or more pulsars seen by instruments on the Compton Gamma Ray Observatory (CGRO) show that: the light curves usually have double-peak structures (suggesting a broad cone of emission); gamma rays are frequently the dominant component of the radiated power; and all the spectra show evidence of a high-energy turnover. For all the known gamma-ray pulsars, multiwavelength observations and theoretical models based on such observations offer the prospect of gaining a broad understanding of these rotating neutron stars. The Gamma-ray Large Area Space Telescope (GLAST), now in planning for a launch in 2006, will provide a major advance in sensitivity, energy range, and sky coverage.

  2. Chromosomal Aberrations in Normal and AT Cells Exposed to High Dose of Low Dose Rate Irradiation

    NASA Technical Reports Server (NTRS)

    Kawata, T.; Shigematsu, N.; Kawaguchi, O.; Liu, C.; Furusawa, Y.; Hirayama, R.; George, K.; Cucinotta, F.

    2011-01-01

    Ataxia telangiectasia (A-T) is a human autosomally recessive syndrome characterized by cerebellar ataxia, telangiectases, immune dysfunction, and genomic instability, and high rate of cancer incidence. A-T cell lines are abnormally sensitive to agents that induce DNA double strand breaks, including ionizing radiation. The diverse clinical features in individuals affected by A-T and the complex cellular phenotypes are all linked to the functional inactivation of a single gene (AT mutated). It is well known that cells deficient in ATM show increased yields of both simple and complex chromosomal aberrations after high-dose-rate irradiation, but, less is known on how cells respond to low-dose-rate irradiation. It has been shown that AT cells contain a large number of unrejoined breaks after both low-dose-rate irradiation and high-dose-rate irradiation, however sensitivity for chromosomal aberrations at low-dose-rate are less often studied. To study how AT cells respond to low-dose-rate irradiation, we exposed confluent normal and AT fibroblast cells to up to 3 Gy of gamma-irradiation at a dose rate of 0.5 Gy/day and analyzed chromosomal aberrations in G0 using fusion PCC (Premature Chromosomal Condensation) technique. Giemsa staining showed that 1 Gy induces around 0.36 unrejoined fragments per cell in normal cells and around 1.35 fragments in AT cells, whereas 3Gy induces around 0.65 fragments in normal cells and around 3.3 fragments in AT cells. This result indicates that AT cells can rejoin breaks less effectively in G0 phase of the cell cycle? compared to normal cells. We also analyzed chromosomal exchanges in normal and AT cells after exposure to 3 Gy of low-dose-rate rays using a combination of G0 PCC and FISH techniques. Misrejoining was detected in the AT cells only? When cells irradiated with 3 Gy were subcultured and G2 chromosomal aberrations were analyzed using calyculin-A induced PCC technique, the yield of unrejoined breaks decreased in both normal and AT

  3. Gamma ray irradiation for sludge solubilization and biological nitrogen removal

    NASA Astrophysics Data System (ADS)

    Kim, Tak-Hyun; Lee, Myunjoo; Park, Chulhwan

    2011-12-01

    This study was conducted to investigate the effects of gamma ray irradiation on the solubilization of waste sewage sludge. The recovery of an organic carbon source from sewage sludge by gamma ray irradiation was also studied. The gamma ray irradiation showed effective sludge solubilization efficiencies. Both soluble chemical oxygen demand (SCOD) and biochemical oxygen demand (BOD 5) increased by gamma ray irradiation. The feasibility of the solubilized sludge carbon source for a biological nitrogen removal was also investigated. A modified continuous bioreactor (MLE process) for a denitrification was operated for 20 days by using synthetic wastewater. It can be concluded that the gamma ray irradiation was useful for the solubilization of sludge and the recovery of carbon source from the waste sewage sludge for biological nitrogen removal.

  4. Effects of low-dose rate γ-irradiation combined with simulated microgravity on markers of oxidative stress, DNA methylation potential, and remodeling in the mouse heart.

    PubMed

    Seawright, John W; Samman, Yusra; Sridharan, Vijayalakshmi; Mao, Xiao Wen; Cao, Maohua; Singh, Preeti; Melnyk, Stepan; Koturbash, Igor; Nelson, Gregory A; Hauer-Jensen, Martin; Boerma, Marjan

    2017-01-01

    Space travel is associated with an exposure to low-dose rate ionizing radiation and the microgravity environment, both of which may lead to impairments in cardiac function. We used a mouse model to determine short- and long-term cardiac effects to simulated microgravity (hindlimb unloading; HU), continuous low-dose rate γ-irradiation, or a combination of HU and low-dose rate γ-irradiation. Cardiac tissue was obtained from female, C57BL/6J mice 7 days, 1 month, 4 months, and 9 months following the completion of a 21 day exposure to HU or a 21 day exposure to low-dose rate γ-irradiation (average dose rate of 0.01 cGy/h to a total of 0.04 Gy), or a 21 day simultaneous exposure to HU and low-dose rate γ-irradiation. Immunoblot analysis, rt-PCR, high-performance liquid chromatography, and histology were used to assess inflammatory cell infiltration, cardiac remodeling, oxidative stress, and the methylation potential of cardiac tissue in 3 to 6 animals per group. The combination of HU and γ-irradiation demonstrated the strongest increase in reduced to oxidized glutathione ratios 7 days and 1 month after treatment, but a difference was no longer apparent after 9 months. On the other hand, no significant changes in 4-hydroxynonenal adducts was seen in any of the groups, at the measured endpoints. While manganese superoxide dismutase protein levels decreased 9 months after low-dose γ-radiation, no changes were observed in expression of catalase or Nrf2, a transcription factor that determines the expression of several antioxidant enzymes, at the measured endpoints. Inflammatory marker, CD-2 protein content was significantly decreased in all groups 4 months after treatment. No significant differences were observed in α-smooth muscle cell actin protein content, collagen type III protein content or % total collagen. This study has provided the first and relatively broad analysis of small molecule and protein markers of oxidative stress, T-lymphocyte infiltration, and

  5. Effects of low-dose rate γ-irradiation combined with simulated microgravity on markers of oxidative stress, DNA methylation potential, and remodeling in the mouse heart

    PubMed Central

    Samman, Yusra; Sridharan, Vijayalakshmi; Mao, Xiao Wen; Cao, Maohua; Singh, Preeti; Melnyk, Stepan; Koturbash, Igor; Nelson, Gregory A.; Hauer-Jensen, Martin; Boerma, Marjan

    2017-01-01

    Purpose Space travel is associated with an exposure to low-dose rate ionizing radiation and the microgravity environment, both of which may lead to impairments in cardiac function. We used a mouse model to determine short- and long-term cardiac effects to simulated microgravity (hindlimb unloading; HU), continuous low-dose rate γ-irradiation, or a combination of HU and low-dose rate γ-irradiation. Methods Cardiac tissue was obtained from female, C57BL/6J mice 7 days, 1 month, 4 months, and 9 months following the completion of a 21 day exposure to HU or a 21 day exposure to low-dose rate γ-irradiation (average dose rate of 0.01 cGy/h to a total of 0.04 Gy), or a 21 day simultaneous exposure to HU and low-dose rate γ-irradiation. Immunoblot analysis, rt-PCR, high-performance liquid chromatography, and histology were used to assess inflammatory cell infiltration, cardiac remodeling, oxidative stress, and the methylation potential of cardiac tissue in 3 to 6 animals per group. Results The combination of HU and γ-irradiation demonstrated the strongest increase in reduced to oxidized glutathione ratios 7 days and 1 month after treatment, but a difference was no longer apparent after 9 months. On the other hand, no significant changes in 4-hydroxynonenal adducts was seen in any of the groups, at the measured endpoints. While manganese superoxide dismutase protein levels decreased 9 months after low-dose γ-radiation, no changes were observed in expression of catalase or Nrf2, a transcription factor that determines the expression of several antioxidant enzymes, at the measured endpoints. Inflammatory marker, CD-2 protein content was significantly decreased in all groups 4 months after treatment. No significant differences were observed in α-smooth muscle cell actin protein content, collagen type III protein content or % total collagen. Conclusions This study has provided the first and relatively broad analysis of small molecule and protein markers of oxidative stress

  6. High energy gamma ray astronomy

    NASA Technical Reports Server (NTRS)

    Fichtel, Carl E.

    1987-01-01

    High energy gamma ray astronomy has evolved with the space age. Nonexistent twenty-five years ago, there is now a general sketch of the gamma ray sky which should develop into a detailed picture with the results expected to be forthcoming over the next decade. The galactic plane is the dominant feature of the gamma ray sky, the longitude and latitude distribution being generally correlated with galactic structural features including the spiral arms. Two molecular clouds were already seen. Two of the three strongest gamma ray sources are pulsars. The highly variable X-ray source Cygnus X-3 was seen at one time, but not another in the 100 MeV region, and it was also observed at very high energies. Beyond the Milky Way Galaxy, there is seen a diffuse radiation, whose origin remains uncertain, as well as at least one quasar, 3C 273. Looking to the future, the satellite opportunities for high energy gamma ray astronomy in the near term are the GAMMA-I planned to be launched in late 1987 and the Gamma Ray Observatory, scheduled for launch in 1990. The Gamma Ray Observatory will carry a total of four instruments covering the entire energy range from 30,000 eV to 3 x 10 to the 10th eV with over an order of magnitude increase in sensitivity relative to previous satellite instruments.

  7. Multi-Level Effects of Low Dose Rate Ionizing Radiation on Southern Toad, Anaxyrus [Bufo] terrestris

    PubMed Central

    Stark, Karolina; Scott, David E.; Tsyusko, Olga; Coughlin, Daniel P.; Hinton, Thomas G.

    2015-01-01

    Despite their potential vulnerability to contaminants from exposure at multiple life stages, amphibians are one of the least studied groups of vertebrates in ecotoxicology, and research on radiation effects in amphibians is scarce. We used multiple endpoints to assess the radiosensitivity of the southern toad (Anaxyrus [Bufo] terrestris) during its pre-terrestrial stages of development –embryonic, larval, and metamorphic. Toads were exposed, from several hours after oviposition through metamorphosis (up to 77 days later), to four low dose rates of 137Cs at 0.13, 2.4, 21, and 222 mGy d-1, resulting in total doses up to 15.8 Gy. Radiation treatments did not affect hatching success of embryos, larval survival, or the length of the larval period. The individual family variation in hatching success of embryos was larger than the radiation response. In contrast, newly metamorphosed individuals from the higher dose-rate treatments had higher mass and mass/length body indices, a measure which may relate to higher post-metamorphic survival. The increased mass and index at higher dose rates may indicate that the chronic, low dose rate radiation exposures triggered secondary responses. Additionally, the increases in growth were linked to a decrease in DNA damage (as measured by the Comet Assay) in red blood cells at a dose rate of 21 mGy d-1 and a total dose of 1.1 Gy. In conclusion, the complex effects of low dose rates of ionizing radiation may trigger growth and cellular repair mechanisms in amphibian larvae. PMID:25927361

  8. Multi-level effects of low dose rate ionizing radiation on southern toad, Anaxyrus [Bufo] terrestris

    DOE PAGES

    Stark, Karolina; Scott, David E.; Tsyusko, Olga; ...

    2015-04-30

    Despite their potential vulnerability to contaminants from exposure at multiple life stages, amphibians are one of the least studied groups of vertebrates in ecotoxicology, and research on radiation effects in amphibians is scarce. We used multiple endpoints to assess the radiosensitivity of the southern toad (Anaxyrus [Bufo] terrestris) during its pre-terrestrial stages of development –embryonic, larval, and metamorphic. Toads were exposed, from several hours after oviposition through metamorphosis (up to 77 days later), to four low dose rates of ¹³⁷Cs at 0.13, 2.4, 21, and 222 mGy d⁻¹, resulting in total doses up to 15.8 Gy. Radiation treatments did notmore » affect hatching success of embryos, larval survival, or the length of the larval period. The individual family variation in hatching success of embryos was larger than the radiation response. In contrast, newly metamorphosed individuals from the higher dose-rate treatments had higher mass and mass/length body indices, a measure which may relate to higher post-metamorphic survival. The increased mass and index at higher dose rates may indicate that the chronic, low dose rate radiation exposures triggered secondary responses. Additionally, the increases in growth were linked to a decrease in DNA damage (as measured by the Comet Assay) in red blood cells at a dose rate of 21mGy d⁻¹ and a total dose of 1.1 Gy. In conclusion, the complex effects of low dose rates of ionizing radiation may trigger growth and cellular repair mechanisms in amphibian larvae.« less

  9. Multi-Level Effects of Low Dose Rate Ionizing Radiation on Southern Toad, Anaxyrus [Bufo] terrestris.

    PubMed

    Stark, Karolina; Scott, David E; Tsyusko, Olga; Coughlin, Daniel P; Hinton, Thomas G

    2015-01-01

    Despite their potential vulnerability to contaminants from exposure at multiple life stages, amphibians are one of the least studied groups of vertebrates in ecotoxicology, and research on radiation effects in amphibians is scarce. We used multiple endpoints to assess the radiosensitivity of the southern toad (Anaxyrus [Bufo] terrestris) during its pre-terrestrial stages of development -embryonic, larval, and metamorphic. Toads were exposed, from several hours after oviposition through metamorphosis (up to 77 days later), to four low dose rates of 137Cs at 0.13, 2.4, 21, and 222 mGy d-1, resulting in total doses up to 15.8 Gy. Radiation treatments did not affect hatching success of embryos, larval survival, or the length of the larval period. The individual family variation in hatching success of embryos was larger than the radiation response. In contrast, newly metamorphosed individuals from the higher dose-rate treatments had higher mass and mass/length body indices, a measure which may relate to higher post-metamorphic survival. The increased mass and index at higher dose rates may indicate that the chronic, low dose rate radiation exposures triggered secondary responses. Additionally, the increases in growth were linked to a decrease in DNA damage (as measured by the Comet Assay) in red blood cells at a dose rate of 21 mGy d-1 and a total dose of 1.1 Gy. In conclusion, the complex effects of low dose rates of ionizing radiation may trigger growth and cellular repair mechanisms in amphibian larvae.

  10. Excess processing of oxidative damaged bases causes hypersensitivity to oxidative stress and low dose rate irradiation.

    PubMed

    Yoshikawa, Y; Yamasaki, A; Takatori, K; Suzuki, M; Kobayashi, J; Takao, M; Zhang-Akiyama, Q-M

    2015-10-01

    Ionizing radiations such as X-ray and γ-ray can directly or indirectly produce clustered or multiple damages in DNA. Previous studies have reported that overexpression of DNA glycosylases in Escherichia coli (E. coli) and human lymphoblast cells caused increased sensitivity to γ-ray and X-ray irradiation. However, the effects and the mechanisms of other radiation, such as low dose rate radiation, heavy-ion beams, or hydrogen peroxide (H2O2), are still poorly understood. In the present study, we constructed a stable HeLaS3 cell line overexpressing human 8-oxoguanine DNA N-glycosylase 1 (hOGG1) protein. We determined the survival of HeLaS3 and HeLaS3/hOGG1 cells exposed to UV, heavy-ion beams, γ-rays, and H2O2. The results showed that HeLaS3 cells overexpressing hOGG1 were more sensitive to γ-rays, OH(•), and H2O2, but not to UV or heavy-ion beams, than control HeLaS3. We further determined the levels of 8-oxoG foci and of chromosomal double-strand breaks (DSBs) by detecting γ-H2AX foci formation in DNA. The results demonstrated that both γ-rays and H2O2 induced 8-oxoguanine (8-oxoG) foci formation in HeLaS3 cells. hOGG1-overexpressing cells had increased amounts of γ-H2AX foci and decreased amounts of 8-oxoG foci compared with HeLaS3 control cells. These results suggest that excess hOGG1 removes the oxidatively damaged 8-oxoG in DNA more efficiently and therefore generates more DSBs. Micronucleus formation also supported this conclusion. Low dose-rate γ-ray effects were also investigated. We first found that overexpression of hOGG1 also caused increased sensitivity to low dose rate γ-ray irradiation. The rate of micronucleus formation supported the notion that low dose rate irradiation increased genome instability.

  11. The Gamma-Ray Imaging Spectrometer (GRIS): A new balloon-borne experiment for gamma-ray line astronomy

    NASA Astrophysics Data System (ADS)

    Teegarden, B. J.; Cline, T. L.; Gehrels, N.; Porreca, G.; Tueller, J.; Leventhal, M.; Huters, A. F.; MacCallum, C. J.; Stang, P. D.

    1985-08-01

    High resolution gamma-ray spectroscopy is a relatively new field that holds great promise for further understanding of high energy astrophysical processes. When the high resolution gamma-ray spectrometer (GRSE) was removed from the GRO payload, a balloon program was initiated to permit continued development and improvement of instrumentation in this field, as well as continued scientific observations. The Gamma-Ray Imaging Spectrometer (GRIS) is one of the experiments selected as part of this program. The instrument contains a number of new and innovative features that are expected to produce a significant improvement in source location accuracy and sensitivity over previous balloon and satellite experiments.

  12. Jet Shockwaves Produce Gamma Rays

    NASA Image and Video Library

    Theorists believe that GRB jets produce gamma rays by two processes involving shock waves. Shells of material within the jet move at different speeds and collide, generating internal shock waves th...

  13. Gamma rays at airplane altitudes

    SciTech Connect

    Iwai, J.; Koss, T.; Lord, J.; Strausz, S.; Wilkes, J.; Woosley, J. )

    1990-03-20

    An examination of the gamma ray flux above 1 TeV in the atmosphere is needed to better understand the anomalous showers from point sources. Suggestions are made for future experiments on board airplanes.

  14. Gamma-ray-selected AGN

    NASA Astrophysics Data System (ADS)

    Giommi, Paolo

    2016-08-01

    The gamma-ray band is the most energetic part of the electromagnetic spectrum. As such it is also where selection effects are most severe, as it can only be reached by the most extreme non-thermal AGN. Blazars, with their emission dominated by non-thermal blue-shifted radiation arising in a relativistic jet pointed in the direction of the observer, naturally satisfy this though requirement. For this reason, albeit these sources are intrisically very rare (orders of magnitude less abundant than radio quiet AGN of the same optical magnitude) they almost completely dominate the extragalactic gamma-ray and very high energy sky. I will discuss the emission of different types of blazars and the selection effects that are at play in the gamma-ray band based on recent results from the current generation of gamma-ray astronomy satellites, ground-based Cherenkov telescopes, and Monte Carlo simulations.

  15. Directional detector of gamma rays

    DOEpatents

    Cox, Samson A.; Levert, Francis E.

    1979-01-01

    A directional detector of gamma rays comprises a strip of an electrical cuctor of high atomic number backed with a strip of a second electrical conductor of low atomic number. These elements are enclosed within an electrical conductor that establishes an electrical ground, maintains a vacuum enclosure and screens out low-energy gamma rays. The detector exhibits a directional sensitivity marked by an increased output in the favored direction by a factor of ten over the output in the unfavored direction.

  16. Positronium Annihilation Gamma Ray Laser

    DTIC Science & Technology

    2009-07-01

    estimate of the ignition threshold for DT fuel heated by a burst from an annihilation gamma ray laser; and (IV) A new concept for more rapid laser...distribution; (III) A theoretical estimate of the ignition threshold for DT fuel heated by a burst from an annihilation gamma ray laser; and (IV) A new ...II. Development of Laser systems 26 III. Preliminary estimate of DT ignition 31 IV. New method for cooling positronium 34 CONCLUSIONS

  17. About cosmic gamma ray lines

    NASA Astrophysics Data System (ADS)

    Diehl, Roland

    2017-06-01

    Gamma ray lines from cosmic sources convey the action of nuclear reactions in cosmic sites and their impacts on astrophysical objects. Gamma rays at characteristic energies result from nuclear transitions following radioactive decays or high-energy collisions with excitation of nuclei. The gamma-ray line from the annihilation of positrons at 511 keV falls into the same energy window, although of different origin. We present here the concepts of cosmic gamma ray spectrometry and the corresponding instruments and missions, followed by a discussion of recent results and the challenges and open issues for the future. Among the lessons learned are the diffuse radioactive afterglow of massive-star nucleosynthesis in 26Al and 60Fe gamma rays, which is now being exploited towards the cycle of matter driven by massive stars and their supernovae; large interstellar cavities and superbubbles have been recognised to be of key importance here. Also, constraints on the complex processes making stars explode as either thermonuclear or core-collapse supernovae are being illuminated by gamma-ray lines, in this case from shortlived radioactivities from 56Ni and 44Ti decays. In particular, the three-dimensionality and asphericities that have recently been recognised as important are enlightened in different ways through such gamma-ray line spectroscopy. Finally, the distribution of positron annihilation gamma ray emission with its puzzling bulge-dominated intensity disctribution is measured through spatially-resolved spectra, which indicate that annihilation conditions may differ in different parts of our Galaxy. But it is now understood that a variety of sources may feed positrons into the interstellar medium, and their characteristics largely get lost during slowing down and propagation of positrons before annihilation; a recent microquasar flare was caught as an opportunity to see positrons annihilate at a source.

  18. Low Dose Rate Radiosensitization of Hepatocellular Carcinoma In Vitro and in Patients1

    PubMed Central

    Cuneo, Kyle C.; Davis, Mary A.; Feng, Mary U.; Novelli, Paula M.; Ensminger, William D.; Lawrence, Theodore S.

    2014-01-01

    Transarterial radioembolization (TARE) with 90Y microspheres delivers low dose rate radiation (LDR) to intrahepatic tumors. In the current study, we examined clonogenic survival, DNA damage, and cell cycle distribution in hepatocellular carcinoma (HCC) cell lines treated with LDR in combination with varying doses and schedules of 5-fluorouracil (5-FU), gemcitabine, and sorafenib. Radiosensitization was seen with 1 to 3 μM 5-FU (enhancement ratio 2.2–13.9) and 30 to 100 nM gemcitabine (enhancement ratio 1.9–2.9) administered 24 hours before LDR (0.26 Gy/h to 4.2 Gy). Sorafenib radiosensitized only at high concentrations (3–10 μM) when administered after LDR. For a given radiation dose, greater enhancement was seen with LDR compared to standard dose rate therapy. Summarizing our clinical experience with low dose rate radiosensitization, 13 patients (5 with HCC, 8 with liver metastases) were treated a total of 16 times with TARE and concurrent gemcitabine. Six partial responses and one complete response were observed with a median time to local failure of 7.1 months for all patients and 9.9 months for patients with HCC. In summary, HCC is sensitized to LDR with clinically achievable concentrations of gemcitabine and 5-FU in vitro. Encouraging responses were seen in a small cohort of patients treated with TARE and concurrent gemcitabine. Future studies are needed to validate the safety and efficacy of this approach. PMID:24956939

  19. Regeneration of Murine Hair Follicles is Inhibited by Low-Dose-Rate Gamma Irradiation.

    PubMed

    Sugaya, Kimihiko; Hirobe, Tomohisa; Ishihara, Yoshie; Inoue, Sonoe

    2016-10-01

    To determine whether the effects of low-dose-rate gamma (γ) irradiation are identifiable in the regeneration of murine hair follicles, we irradiated whole bodies of C57BL/10JHir mice in the first telogen phase of the hair cycle with (137)Cs γ-rays. The mice were examined for effects on hair follicles, including number, morphology, and pigmentation in the second anagen phase. Effects of γ-radiation on melanocyte stem cells were also investigated by the indirect immunolabeling of tyrosinase-related protein 2 (TRP2). Irradiated skin showed a decrease in hair follicle density and the induction of curved hair follicles along with the presence of white hairs and hypopigmented hair bulbs. There was a small, but not significant, change in the number of TRP2-positive melanocyte stem cells in the hair bulge region of the irradiated skin. These results suggest that low-dose rate γ-irradiation does not deplete melanocyte stem cells, but can damage stem cells and progenitors for both keratinocytes and melanocytes, thereby affecting the structure and pigmentation of regenerated hair follicles in the 2(nd) anagen phase.

  20. Gamma-Ray Bursts: A Mystery Story

    NASA Technical Reports Server (NTRS)

    Parsons, Ann

    2007-01-01

    With the success of the Swift Gamma-Ray Burst Explorer currently in orbit, this is quite an exciting time in the history of Gamma Ray Bursts (GRBs). The study of GRBs is a modern astronomical mystery story that began over 30 years ago with the serendipitous discovery of these astronomical events by military satellites in the late 1960's. Until the launch of BATSE on the Compton Gamma-ray Observatory, astronomers had no clue whether GRBs originated at the edge of our solar system, in our own Milky Way Galaxy or incredibly far away near the edge of the observable Universe. Data from BATSE proved that GRBs are distributed isotropically on the sky and thus could not be the related to objects in the disk of our Galaxy. Given the intensity of the gamma-ray emission, an extragalactic origin would require an astounding amount of energy. Without sufficient data to decide the issue, a great debate continued about whether GRBs were located in the halo of our own galaxy or were at extragalactic - even cosmological distances. This debate continued until 1997 when the BeppoSAX mission discovered a fading X-ray afterglow signal in the same location as a GRB. This discovery enabled other telescopes, to observe afterglow emission at optical and radio wavelengths and prove that GRBs were at cosmological distances by measuring large redshifts in the optical spectra. Like BeppoSAX Swift, slews to new GRB locations to measure afterglow emission. In addition to improved GRB sensitivity, a significant advantage of Swift over BeppoSAX and other missions is its ability to slew very quickly, allowing x-ray and optical follow-up measurements to be made as early as a minute after the gamma-ray burst trigger rather than the previous 6-8 hour delay. Swift afterglow measurements along with follow-up ground-based observations, and theoretical work have allowed astronomers to identify two plausible scenarios for the creation of a GRB: either through core collapse of super massive stars or

  1. Gamma-Ray Bursts: A Mystery Story

    NASA Technical Reports Server (NTRS)

    Parsons, Ann

    2007-01-01

    With the success of the Swift Gamma-Ray Burst Explorer currently in orbit, this is quite an exciting time in the history of Gamma Ray Bursts (GRBs). The study of GRBs is a modern astronomical mystery story that began over 30 years ago with the serendipitous discovery of these astronomical events by military satellites in the late 1960's. Until the launch of BATSE on the Compton Gamma-ray Observatory, astronomers had no clue whether GRBs originated at the edge of our solar system, in our own Milky Way Galaxy or incredibly far away near the edge of the observable Universe. Data from BATSE proved that GRBs are distributed isotropically on the sky and thus could not be the related to objects in the disk of our Galaxy. Given the intensity of the gamma-ray emission, an extragalactic origin would require an astounding amount of energy. Without sufficient data to decide the issue, a great debate continued about whether GRBs were located in the halo of our own galaxy or were at extragalactic - even cosmological distances. This debate continued until 1997 when the BeppoSAX mission discovered a fading X-ray afterglow signal in the same location as a GRB. This discovery enabled other telescopes, to observe afterglow emission at optical and radio wavelengths and prove that GRBs were at cosmological distances by measuring large redshifts in the optical spectra. Like BeppoSAX Swift, slews to new GRB locations to measure afterglow emission. In addition to improved GRB sensitivity, a significant advantage of Swift over BeppoSAX and other missions is its ability to slew very quickly, allowing x-ray and optical follow-up measurements to be made as early as a minute after the gamma-ray burst trigger rather than the previous 6-8 hour delay. Swift afterglow measurements along with follow-up ground-based observations, and theoretical work have allowed astronomers to identify two plausible scenarios for the creation of a GRB: either through core collapse of super massive stars or

  2. The Compton Gamma Ray Observatory

    NASA Astrophysics Data System (ADS)

    Gehrels, N.; Chipman, E.; Kniffen, D. A.

    1993-01-01

    The Arthur Holly Compton Gamma Ray Observatory (Compton) was launched by the Space Shuttle Atlantis on 5 April 1991. The spacecraft and instruments are in good health and returning exciting results. The mission provides nearly six orders of magnitude in spectral coverage, from 30 keV to 30 GeV, with sensitivity over the entire range an order of magnitude better than that of previous observations. The 16,000 kilogram observatory contains four instruments on a stabilized platform. The mission began normal operations on 16 May 1991 and is now over half-way through a full-sky survey. The mission duration is expected to be from six to ten years. A Science Support Center has been established at Goddard Space Flight Center for the purpose of supporting a vigorous Guest Investigator Program. New scientific results to date include: (1) the establishment of the isotropy, combined with spatial inhomogeneity, of the distribution of gamma-ray bursts in the sky; (2) the discovery of intense high energy (100 MeV) gamma-ray emission from 3C 279 and other quasars and BL Lac objects, making these the most distant and luminous gamma-ray sources ever detected; (3) one of the first images of a gamma-ray burst; (4) the observation of intense nuclear and position-annihilation gamma-ray lines and neutrons from several large solar flares; and (5) the detection of a third gamma-ray pulsar, plus several other transient and pulsing hard X-ray sources.

  3. The Compton Gamma Ray Observatory: mission status.

    NASA Astrophysics Data System (ADS)

    Gehrels, N.; Chipman, E.; Kniffen, D. A.

    The Arthur Holly Compton Gamma Ray Observatory (Compton) is the second in NASA's series of Great Observatories. Compton has now been operating for over two and a half years, and has given a dramatic increase in capability over previous gamma-ray missions. The spacecraft and scientific instruments are all in good health, and many significant discoveries have already been made and continue to be made. The authors describe the capabilities of the four scientific instruments and the observing programs for the first three years of the mission. During Phases 2 and 3 of the mission a Guest Investigator program has been in progress with the Guest Observers' time share increasing from 30% to over 50% for the later mission phases.

  4. Measurement uncertainty analysis of low-dose-rate prostate seed brachytherapy: post-implant dosimetry.

    PubMed

    Gregory, Kent J; Pattison, John E; Bibbo, Giovanni

    2015-03-01

    The minimal dose covering 90 % of the prostate volume--D 90--is arguably the most important dosimetric parameter in low-dose-rate prostate seed brachytherapy. In this study an analysis of the measurement uncertainties in D 90 from low-dose-rate prostate seed brachytherapy was conducted for two common treatment procedures with two different post-implant dosimetry methods. The analysis was undertaken in order to determine the magnitude of D 90 uncertainty, how the magnitude of the uncertainty varied when D 90 was calculated using different dosimetry methods, and which factors were the major contributors to the uncertainty. The analysis considered the prostate as being homogeneous and tissue equivalent and made use of published data, as well as original data collected specifically for this analysis, and was performed according to the Guide to the expression of uncertainty in measurement (GUM). It was found that when prostate imaging and seed implantation were conducted in two separate sessions using only CT images for post-implant analysis, the expanded uncertainty in D 90 values were about 25 % at the 95 % confidence interval. When prostate imaging and seed implantation were conducted during a single session using CT and ultrasound images for post-implant analysis, the expanded uncertainty in D 90 values were about 33 %. Methods for reducing these uncertainty levels are discussed. It was found that variations in contouring the target tissue made the largest contribution to D 90 uncertainty, while the uncertainty in seed source strength made only a small contribution. It is important that clinicians appreciate the overall magnitude of D 90 uncertainty and understand the factors that affect it so that clinical decisions are soundly based, and resources are appropriately allocated.

  5. Long-term results of breast cancer irradiation treatment with low-dose-rate external irradiation

    SciTech Connect

    Pierquin, Bernard; Tubiana, Maurice . E-mail: maurice.tubiana@biomedicale.univ-paris5.fr; Pan, Camille; Lagrange, Jean-Leon; Calitchi, Elie; Otmezguine, Yves

    2007-01-01

    Purpose: The aim of this study was to assess beam therapy with low-dose-rate (LDR) external irradiation in a group of patients with breast cancer. Methods and Materials: This trial compared, from 1986 to 1989, patients with advanced breast cancer treated either by conventional fractionation or low-dose-rate (LDR) external radiotherapy (dose-rate 15 mGy/min, 5 sessions of 9 Gy delivered on 5 consecutive days). Results: A total of 21 patients were included in the fractionated therapy arm. At follow-up 15 years after treatment, 7 local recurrences had occurred, 3 patients had died of cancer, 18 patients were alive, 10 were without evidence of disease, and 6 had evidence of disease. A total of 22 patients had been included in the LDR arm of the study. Of these, 11 had received a dose of 45 Gy; thereafter, in view of severe local reactions, the dose was reduced to 35 Gy. There was no local recurrence in patients who had received 45 Gy, although there were 2 local recurrences among the 11 patients after 35 Gy. The sequelae were severe in patients who received 45 Gy but were comparable to those observed in patients treated by fractionated radiotherapy who received 35 Gy. The higher efficacy of tumor control in patients treated by LDR irradiation as well as the lower tolerance of normal tissue are probably related to the lack of repopulation. Conclusion: Although the patient numbers in this study are limited, based on our study results we conclude that the data for LDR irradiation are encouraging and that further investigation is warranted.

  6. Prospects for quantitative two-dimensional radiochromic film dosimetry for low dose-rate brachytherapy sources

    SciTech Connect

    Le Yi; Ali, Imad; Dempsey, James F.; Williamson, Jeffrey F.

    2006-12-15

    Radiochromic film (RCF) has been shown to be a precise and accurate two-dimensional dosimeter for acute exposure radiation fields. However, ''temporal history'' mismatch between calibration and brachytherapy films due to RCF dose-rate effects could introduce potentially large uncertainties in low dose-rate (LDR) brachytherapy absolute dose measurement. This article presents a quantitative evaluation of the precision and accuracy of a laser scanner-based RCF-dosimetry system and the effect of the temporal history mismatch in LDR absolute dose measurement. MD-55-2 RCF was used to measure absolute dose for a low dose-rate {sup 137}Cs brachytherapy source using both single- and double-exposure techniques. Dose-measurement accuracy was evaluated by comparing RCF to Monte Carlo photon-transport simulation. The temporal history mismatch effect was investigated by examining dependence of RCF accuracy on irradiation-to-densitometry time interval. The predictions of the empirical cumulative dose superposition model (CDSM) were compared with measurements. For the double-exposure technique, the agreement between measurement and Monte Carlo simulation was better than 4% in the 3-60 Gy dose range with measurement precisions (coverage factor k=1) of <2% and <6% for the doses greater or less than 3 Gy, respectively. The overall uncertainty (k=1) of dose rate/air-kerma strength measurements achievable by this dosimetry system for a spatial resolution of 0.1 mm is less than 4% for doses greater than 5 Gy. The measured temporal history mismatch systematic error is about 1.8% for a 48 h postexposure time when using the double exposure technique and agrees with CDSM's prediction qualitatively. This work demonstrates that the model MD-55-2 RCF detector has the potential to support quantitative dose measurements about LDR brachytherapy sources with precision and accuracy better than that of previously described dosimeters. The impacts of this work on the future use of new type of RCF

  7. Emesis as a Screening Diagnostic for Low Dose Rate (LDR) Total Body Radiation Exposure

    PubMed Central

    Camarata, A. S.; Switchenko, J. M.; Demidenko, E.; Flood, A. B.; Swartz, H. M.; Ali, A. N.

    2015-01-01

    Current radiation disaster manuals list the time-to-emesis (TE) as the key triage indicator of radiation dose. The data used to support TE recommendations were derived primarily from nearly instantaneous, high dose rate exposures as part of variable condition accident databases. To date, there has not been a systematic differentiation between triage dose estimates associated with high and low dose rate (LDR) exposures, even though it is likely that after a nuclear detonation or radiologic disaster, many surviving casualties would have received a significant portion of their total exposure from fallout (LDR exposure) rather than from the initial nuclear detonation or criticality event (high dose rate exposure). This commentary discusses the issues surrounding the use of emesis as a screening diagnostic for radiation dose after LDR exposure. As part of this discussion, previously published clinical data on emesis after LDR total body irradiation (TBI) is statistically re-analyzed as an illustration of the complexity of the issue and confounding factors. This previously published data includes 107 patients who underwent TBI up to 10.5 Gy in a single fraction delivered over several hours at 0.02 to 0.04 Gy/min. Estimates based on these data for the sensitivity of emesis as a screening diagnostic for low dose rate radiation exposure range from 57.1% to 76.6%, and the estimates for specificity range from 87.5% to 99.4%. Though the original data contain multiple confounding factors, the evidence regarding sensitivity suggests that emesis appears to be quite poor as a medical screening diagnostic for LDR exposures. PMID:26910032

  8. The Gamma-Ray Observatory

    SciTech Connect

    Kniffen, D.A. )

    1989-01-01

    The scientific goals and the design of the NASA Gamma-Ray Observatory (GRO), planned for launch in mid-1990, are described together with the experiments to be performed on the GRO mission and the instruments to be flown on the Observatory. GRO contains a complement of four instruments to span the spectrum from 0.03 to 20,000 MeV in energy, three of which are optimized to make gamma-ray observations using either the photoelectric effect, the Compton scatter, or the pair production processes; the fourth instrument is optimized for high-sensitivity observations of transient events and time-variable sources. The instruments are the Oriented Scintillation Spectrometer Experiment, the Compton Telescope, the Energetic Gamma-Ray Experiment Telescope, and the Burst and Transient Source Experiment.

  9. Recent developments in semiconductor gamma-ray detectors

    SciTech Connect

    Luke, Paul N.; Amman, Mark; Tindall, Craig; Lee, Julie S.

    2003-10-28

    The successful development of lithium-drifted Ge detectors in the 1960's marked the beginning of the significant use of semiconductor crystals for direct detection and spectroscopy of gamma rays. In the 1970's, high-purity Ge became available, which enabled the production of complex detectors and multi-detector systems. In the following decades, the technology of semiconductor gamma-ray detectors continued to advance, with significant developments not only in Ge detectors but also in Si detectors and room-temperature compound-semiconductor detectors. In recent years, our group at Lawrence Berkeley National Laboratory has developed a variety of gamma ray detectors based on these semiconductor materials. Examples include Ge strip detectors, lithium-drifted Si strip detectors, and coplanar-grid CdZnTe detectors. These advances provide new capabilities in the measurement of gamma rays, such as the ability to perform imaging and the realization of highly compact spectroscopy systems.

  10. Chronic Low Dose Rate Ionizing Radiation Exposure Induces Premature Senescence in Human Fibroblasts that Correlates with Up Regulation of Proteins Involved in Protection against Oxidative Stress

    PubMed Central

    Loseva, Olga; Shubbar, Emman; Haghdoost, Siamak; Evers, Bastiaan; Helleday, Thomas; Harms-Ringdahl, Mats

    2014-01-01

    The risks of non-cancerous diseases associated with exposure to low doses of radiation are at present not validated by epidemiological data, and pose a great challenge to the scientific community of radiation protection research. Here, we show that premature senescence is induced in human fibroblasts when exposed to chronic low dose rate (LDR) exposure (5 or 15 mGy/h) of gamma rays from a 137Cs source. Using a proteomic approach we determined differentially expressed proteins in cells after chronic LDR radiation compared to control cells. We identified numerous proteins involved in protection against oxidative stress, suggesting that these pathways protect against premature senescence. In order to further study the role of oxidative stress for radiation induced premature senescence, we also used human fibroblasts, isolated from a patient with a congenital deficiency in glutathione synthetase (GS). We found that these GS deficient cells entered premature senescence after a significantly shorter time of chronic LDR exposure as compared to the GS proficient cells. In conclusion, we show that chronic LDR exposure induces premature senescence in human fibroblasts, and propose that a stress induced increase in reactive oxygen species (ROS) is mechanistically involved. PMID:28250385

  11. The Gamma-ray Sky with Fermi

    NASA Technical Reports Server (NTRS)

    Thompson, David

    2012-01-01

    Gamma rays reveal extreme, nonthermal conditions in the Universe. The Fermi Gamma-ray Space Telescope has been exploring the gamma-ray sky for more than four years, enabling a search for powerful transients like gamma-ray bursts, novae, solar flares, and flaring active galactic nuclei, as well as long-term studies including pulsars, binary systems, supernova remnants, and searches for predicted sources of gamma rays such as dark matter annihilation. Some results include a stringent limit on Lorentz invariance derived from a gamma-ray burst, unexpected gamma-ray variability from the Crab Nebula, a huge gamma-ray structure associated with the center of our galaxy, surprising behavior from some gamma-ray binary systems, and a possible constraint on some WIMP models for dark matter.

  12. Gamma-ray Imaging Methods

    SciTech Connect

    Vetter, K; Mihailescu, L; Nelson, K; Valentine, J; Wright, D

    2006-10-05

    In this document we discuss specific implementations for gamma-ray imaging instruments including the principle of operation and describe systems which have been built and demonstrated as well as systems currently under development. There are several fundamentally different technologies each with specific operational requirements and performance trade offs. We provide an overview of the different gamma-ray imaging techniques and briefly discuss challenges and limitations associated with each modality (in the appendix we give detailed descriptions of specific implementations for many of these technologies). In Section 3 we summarize the performance and operational aspects in tabular form as an aid for comparing technologies and mapping technologies to potential applications.

  13. Biological impact of low dose-rate simulated solar particle event radiation in vivo.

    PubMed

    Chang, P Y; Doppalapudi, R; Bakke, J; Wang, A; Menda, S; Davis, Z

    2010-08-01

    C57Bl6-lacZ animals were exposed to a range of low dose-rate simulated solar particle event (sSPE) radiation at the NASA-sponsored Research Laboratory (NSRL) at Brookhaven National Laboratory (BNL). Peripheral blood was harvested from animals from 1 to 12 days after total body irradiation (TBI) to quantify the level of circulating reticulocytes (RET) and micronucleated reticulocytes (MN-RET) as an early indicator of radiation-induced genotoxicity. Bone marrow lymphocytes and hippocampal tissues from each animal were collected at 12 days and up to two months, to evaluate dose-dependent late effects after sSPE exposure. Early hematopoietic changes show that the % RET was reduced up to 3 days in response to radiation exposure but recovered at 12 days postirradiation. The % MN-RET in peripheral blood was temporally regulated and dependant on the total accumulated dose. Total chromosome aberrations in lymphocytes increased linearly with dose within a week after radiation and remained significantly higher than the control values at 4 weeks after exposure. The level of aberrations in the irradiated animals returned to control levels by 8 weeks postirradiation. Measurements of chromosome 2 and 8 specific aberrations indicate that, consistent with conventional giemsa-staining methods, the level of aberrations is also not significantly higher than in control animals at 8 weeks postirradiation. The hippocampus was surveyed for differential transcriptional regulation of genes known to be associated with neurogenesis. Our results showed differential expression of neurotrophin and their associated receptor genes within 1 week after sSPE exposure. Progressive changes in the profile of expressed genes known to be involved in neurogenic signaling pathways were dependent on the sSPE dose. Our results to date suggest that radiation-induced changes in the hematopoietic system, i.e., chromosome aberrations in lymphocytes, are transient and do not persist past 4 weeks after radiation

  14. In Vitro Cytotoxicity of Low-Dose-Rate Radioimmunotherapy by the Alpha-Emitting Radioimmunoconjugate Thorium-227-DOTA-Rituximab

    SciTech Connect

    Dahle, Jostein; Krogh, Cecilie; Melhus, Katrine B.; Borrebaek, Jorgen; Larsen, Roy H.; Kvinnsland, Yngve

    2009-11-01

    Purpose: To determine whether the low-dose-rate alpha-particle-emitting radioimmunoconjugate {sup 227}Th-1,4,7,10-p-isothiocyanato-benzyl-tetraazacyclododecane-1,4,7, 10-tetraacetic acid (DOTA)-rituximab can be used to inactivate lymphoma cells growing as single cells and small colonies. Methods and Materials: CD20-positive lymphoma cell lines were treated with {sup 227}Th-DOTA-rituximab for 1-5 weeks. To simulate the in vivo situation with continuous but decreasing supply of radioimmunoconjugates from the blood pool, the cells were not washed after incubation with {sup 227}Th-DOTA-rituximab, but half of the medium was replaced with fresh medium, and cell concentration and cell-bound activity were determined every other day after start of incubation. A microdosimetric model was established to estimate the average number of hits in the nucleus for different localizations of activity. Results: There was a specific targeted effect on cell growth of the {sup 227}Th-DOTA-rituximab treatment. Although the cells were not washed after incubation with {sup 227}Th-DOTA-rituximab, the average contribution of activity in the medium to the mean dose was only 6%, whereas the average contribution from activity on the cells' own surface was 78%. The mean dose rates after incubation with 800 Bq/mL {sup 227}Th-DOTA-rituximab varied from 0.01 to 0.03 cGy/min. The average delay in growing from 10{sup 5} to 10{sup 7} cells/mL was 15 days when the cells were treated with a mean absorbed radiation dose of 2 Gy alpha-particle radiation from {sup 227}Th-DOTA-rituximab, whereas it was 11 days when the cells were irradiated with 6 Gy of X-radiation. The relative biologic effect of the treatment was estimated to be 2.9-3.4. Conclusions: The low-dose-rate radioimmunoconjugate {sup 227}Th-DOTA-rituximab is suitable for inactivation of single lymphoma cells and small colonies of lymphoma cells.

  15. Gamma-ray camera flyby

    SciTech Connect

    2010-01-01

    Animation based on an actual classroom demonstration of the prototype CCI-2 gamma-ray camera's ability to image a hidden radioactive source, a cesium-137 line source, in three dimensions. For more information see http://newscenter.lbl.gov/feature-stories/2010/06/02/applied-nuclear-physics/.

  16. Quasars, blazars, and gamma rays.

    PubMed

    Dermer, C D; Schlickeiser, R

    1992-09-18

    Before the launch of the Compton Gamma Ray Observatory (CGRO), the only source of >100-megaelectron volt (MeV) gamma radiation known outside our galaxy was the quasar 3C 273. After less than a year of observing, 13 other extragalactic sources have been discovered with the Energetic Gamma Ray Experiment Telescope (EGRET) on CGRO, and it is expected that many more will be found before the full sky survey is complete. All 14 sources show evidence of blazar properties at other wavelengths; these properties include high optical polarization, extreme optical variability, flat-spectrum radio emission associated with a compact core, and apparent superluminal motion. Such properties are thought to be produced by those few, rare extragalactic radio galaxies and quasars that are favorably aligned to permit us to look almost directly down a relativistically outflowing jet of matter expelled from a supermassive black hole. Although the origin of the gamma rays from radio jets is a subject of much controversy, the gamma-ray window probed by CGRO is providing a wealth of knowledge about the central engines of active galactic nuclei and the most energetic processes occurring in nature.

  17. Gamma-ray Line Astronomy

    NASA Astrophysics Data System (ADS)

    Diehl, R.

    2005-07-01

    Gamma-ray lines from radioactive isotopes, ejected into interstellar space by cosmic nucleosynthesis events, are observed with new space telescopes. The Compton Observatory had provided a sky survey for the isotopes 56Co, 22Na, 44Ti, and 26Al, detecting supernova radioactivity and the diffuse glow of long-lived radioactivity from massive stars in the Galaxy. High-resolution spectroscopy is now being exploited with Ge detectors: Since 2002, with ESA's INTEGRAL satellite and the RHESSI solar imager two space-based Ge-gamma-ray telescopes are in operation, measuring Doppler broadenings and line shape details of cosmic gamma-ray lines. First year's results include a detection and line shape measurement of annihilation emission, and 26Al emission from the inner Galaxy and from the Cygnus region. 60Fe gamma-ray intensity is surprisingly low; it may have been detected by RHESSI at 10% of the 26Al brightness, yet is not seen by INTEGRAL. 44Ti emission from Cas A and SN1987A is being studied; no other candidate young supernova remnants have been found through 44Ti. 22Na from novae still is not seen.

  18. Fermi: The Gamma-Ray Large Area Telescope Mission Status

    NASA Technical Reports Server (NTRS)

    McEnery, Julie

    2014-01-01

    Following its launch in June 2008, high-energy gamma-ray observations by the Fermi Gamma-ray Space Telescope have unveiled over 1000 new sources and opened an important and previously unexplored window on a wide variety of phenomena. These have included the discovery of an population of pulsars pulsing only in gamma rays; the detection of photons up to 10s of GeV from gamma-ray bursts, enhancing our understanding of the astrophysics of these powerful explosions; the detection of hundreds of active galaxies; a measurement of the high energy cosmic-ray electron spectrum which may imply the presence of nearby astrophysical particle accelerators; the determination of the diffuse gamma-ray emission with unprecedented accuracy and the constraints on phenomena such as supersymmetric dark-matter annihilations and exotic relics from the Big Bang. Continuous monitoring of the high-energy gamma-ray sky has uncovered numerous outbursts from active galaxies and the discovery of transient sources in our galaxy. In this talk I will describe the current status of the Fermi observatory and review the science highlights from Fermi.

  19. Fermi: The Gamma-Ray Large Area Telescope

    NASA Technical Reports Server (NTRS)

    McEnery, Julie

    2015-01-01

    Following its launch in June 2008, high-energy gamma-ray observations by the Fermi Gamma-ray Space Telescope have unveiled over 1000 new sources and opened an important and previously unexplored window on a wide variety of phenomena. These have included the discovery of an population of pulsars pulsing only in gamma rays; the detection of photons up to 10s of GeV from gamma-ray bursts, enhancing our understanding of the astrophysics of these powerful explosions; the detection of hundreds of active galaxies; a measurement of the high energy cosmic-ray electron spectrum which may imply the presence of nearby astrophysical particle accelerators; the determination of the diffuse gamma-ray emission with unprecedented accuracy and the constraints on phenomena such as supersymmetric dark-matter annihilations and exotic relics from the Big Bang. Continuous monitoring of the high-energy gamma-ray sky has uncovered numerous outbursts from active galaxies and the discovery of transient sources in our galaxy. In this talk I will describe the current status of the Fermi observatory and review the science highlights from Fermi.

  20. Fermi: The Gamma-Ray Large Area Telescope

    NASA Technical Reports Server (NTRS)

    McEnery, Julie

    2014-01-01

    Following its launch in June 2008, high-energy gamma-ray observations by the Fermi Gamma-ray Space Telescope have unveiled over 1000 new sources and opened an important and previously unexplored window on a wide variety of phenomena. These have included the discovery of an population of pulsars pulsing only in gamma rays; the detection of photons up to 10 seconds of gigaelectronvolts from gamma-ray bursts, enhancing our understanding of the astrophysics of these powerful explosions; the detection of hundreds of active galaxies; a measurement of the high energy cosmic-ray electron spectrum which may imply the presence of nearby astrophysical particle accelerators; the determination of the diffuse gamma-ray emission with unprecedented accuracy and the constraints on phenomena such as super-symmetric dark-matter annihilations and exotic relics from the Big Bang. Continuous monitoring of the high-energy gamma-ray sky has uncovered numerous outbursts from active galaxies and the discovery of transient sources in our galaxy. In this talk I will describe the current status of the Fermi observatory and review the science highlights from Fermi.

  1. Fermi: The Gamma-Ray Large Area Space Telescope

    NASA Technical Reports Server (NTRS)

    McEnery, Julie

    2014-01-01

    Following its launch in June 2008, high-energy gamma-ray observations by the Fermi Gamma-ray Space Telescope have unveiled over 1000 new sources and opened an important and previously unexplored window on a wide variety of phenomena. These have included the discovery of an population of pulsars pulsing only in gamma rays; the detection of photons up to 10s of GeV from gamma-ray bursts, enhancing our understanding of the astrophysics of these powerful explosions; the detection of hundreds of active galaxies; a measurement of the high energy cosmic-ray electron spectrum which may imply the presence of nearby astrophysical particle accelerators; the determination of the diffuse gamma-ray emission with unprecedented accuracy and the constraints on phenomena such as supersymmetric dark-matter annihilations and exotic relics from the Big Bang. Continuous monitoring of the high-energy gamma-ray sky has uncovered numerous outbursts from active galaxies and the discovery of transient sources in our galaxy. In this talk I will describe the current status of the Fermi observatory and review the science highlights from Fermi.

  2. Low-dose-rate, low-dose irradiation delays neurodegeneration in a model of retinitis pigmentosa.

    PubMed

    Otani, Atsushi; Kojima, Hiroshi; Guo, Congrong; Oishi, Akio; Yoshimura, Nagahisa

    2012-01-01

    The existence of radiation hormesis is controversial. Several stimulatory effects of low-dose (LD) radiation have been reported to date; however, the effects on neural tissue or neurodegeneration remain unknown. Here, we show that LD radiation has a neuroprotective effect in mouse models of retinitis pigmentosa, a hereditary, progressive neurodegenerative disease that leads to blindness. Various LD radiation doses were administered to the eyes in a retinal degeneration mouse model, and their pathological and physiological effects were analyzed. LD gamma radiation in a low-dose-rate (LDR) condition rescues photoreceptor cell apoptosis both morphologically and functionally. The greatest effect was observed in a condition using 650 mGy irradiation and a 26 mGy/minute dose rate. Multiple rounds of irradiation strengthened this neuroprotective effect. A characteristic up-regulation (563%) of antioxidative gene peroxiredoxin-2 (Prdx2) in the LDR-LD-irradiated retina was observed compared to the sham-treated control retina. Silencing the Prdx2 using small-interfering RNA administration reduced the LDR-LD rescue effect on the photoreceptors. Our results demonstrate for the first time that LDR-LD irradiation has a biological effect in neural cells of living animals. The results support that radiation exhibits hormesis, and this effect may be applied as a novel therapeutic concept for retinitis pigmentosa and for other progressive neurodegenerative diseases regardless of the mechanism of degeneration involved.

  3. Spectroscopic output of {sup 125}I and {sup 103}Pd low dose rate brachytherapy sources

    SciTech Connect

    Usher-Moga, Jacqueline; Beach, Stephen M.; DeWerd, Larry A.

    2009-01-15

    The spectroscopic output of low dose rate (LDR) brachytherapy sources is dependent on the physical design and construction of the source. Characterization of the emitted photons from 12 {sup 125}I and 3 {sup 103}Pd LDR brachytherapy source models is presented. Photon spectra, both along the transverse bisector and at several polar angles, were measured in air with a high-purity reverse electrode germanium (REGe) detector. Measured spectra were corrected to in vacuo conditions via Monte Carlo and analytical methods. The tabulated and plotted spectroscopic data provide a more complete understanding of each source model's output characteristics than can be obtained with other measurement techniques. The variation in fluorescence yield of the {sup 125}I sources containing silver caused greater differences in the emitted spectra and average energies among these seed models than was observed for the {sup 103}Pd sources or the {sup 125}I sources that do not contain silver. Angular spectroscopic data further highlighted the effects of source construction unique to each model, as well as the asymmetric output of many seeds. These data demonstrate the need for the incorporation of such physically measured output characteristics in the Monte Carlo modeling process.

  4. Targeted cancer therapy with a novel low-dose rate alpha-emitting radioimmunoconjugate.

    PubMed

    Dahle, Jostein; Borrebaek, Jørgen; Jonasdottir, Thora J; Hjelmerud, Anne Kristine; Melhus, Katrine B; Bruland, Øyvind S; Press, Oliver W; Larsen, Roy H

    2007-09-15

    Alpha-emitting radionuclides are highly cytotoxic and are of considerable interest in the treatment of cancer. A particularly interesting approach is in radioimmunotherapy. However, alpha-emitting antibody conjugates have been difficult to exploit clinically due to the short half-life of the radionuclides, low production capability, or limited source materials. We have developed a novel technology based on the low-dose rate alpha-particle-emitting nuclide (227)Th, exemplified here using the monoclonal antibody rituximab. In vitro, this radioimmunoconjugate killed lymphoma cells at Becquerel per milliliter (Bq/mL) levels. A single injection of (227)Th-rituximab induced complete tumor regression in up to 60% of nude mice bearing macroscopic (32-256 mm(3)) human B-lymphoma xenografts at Becquerel per gram (Bq/g) levels without apparent toxicity. Therapy with (227)Th-rituximab was significantly more effective than the control radioimmunoconjugate (227)Th-trastuzumab and the standard beta-emitting radioimmunoconjugate for CD20(+) lymphoma(90)Y-tiuxetan-ibritumomab. Thorium-227 based constructs may provide a novel approach for targeted therapy against a wide variety of cancers.

  5. The effects of low dose rate irradiation and thermal aging on reactor structural alloys

    NASA Astrophysics Data System (ADS)

    Allen, T. R.; Trybus, C. L.; Cole, J. I.

    As part of the EBR-II reactor materials surveillance program, test samples of fifteen different alloys were placed into EBR-II in 1965. The surveillance (SURV) program was intended to determine property changes in reactor structural materials caused by irradiation and thermal aging. In this work, the effect of low dose rate (approximately 2 × 10 -8 dpa/s) irradiation at 380-410°C and long term thermal aging at 371°C on the properties of 20% cold worked 304 stainless steel, 420 stainless steel, Inconel X750, 304/308 stainless weld material, and 17-4 PH steel are evaluated. Doses of up to 6.8 dpa and thermal aging to 2994 days did not significantly affect the density of these alloys. The strength of 304 SS, X750, 17-4 PH, and 304/308 weld material increased with irradiation. In contrast, the strength of 420 stainless steel decreased with irradiation. Irradiation decreased the impact energy in both Inconel X750 and 17-4 PH steel. Thermal aging decreased the impact energy in 17-4 PH steel and increased the impact energy in Inconel X750. Tensile property comparisons of 304 SURV samples with 304 samples irradiated in EBR-II at a higher dose rate show that the higher dose rate samples had greater increases in strength and greater losses in ductility.

  6. Interstitial pneumonitis following bone marrow transplantation after low dose rate total body irradiation

    SciTech Connect

    Barrett, A.; Depledge, M.H.; Powles, R.L.

    1983-07-01

    Idiopathic and infective interstitial pneumonitis (IPn) is a common complication after bone marrow transplantation (BMT) in many centers and carries a high mortality. We report here a series of 107 patients with acute leukemia grafted at the Royal Marsden Hospital in which only 11 (10.3%) developed IPn and only 5 died (5%). Only one case of idiopathic IPn was seen. Factors which may account for this low incidence are discussed. Sixty of 107 patients were transplanted in first remission of acute myeloid leukemia (AML) and were therefore in good general condition. Lung radiation doses were carefully monitored and doses of 10.5 Gy were not exceeded except in a group of 16 patients in whom a study of escalating doses of TBI (up to 13 Gy) was undertaken. The dose rate used for total body irradiation (TBI) was lower than that used in other centers and as demonstrated elsewhere by ourselves and others, reduction of dose rate to <0.05 Gy/min may be expected to lead to substantial reduction in lung damage. Threshold doses of approximately 8 Gy for IPn have been reported, but within the dose range of 8 to 10.5 Gy we suggest that dose rate may significantly affect the incidence. Data so far available suggest a true improvement in therapeutic ratio for low dose rate single fraction TBI compared with high dose rate.

  7. Swift's 500th Gamma Ray Burst

    NASA Image and Video Library

    On April 13, 2010, NASA's Swift Gamma-ray Burst Explorer satellite discovered its 500th burst. Swift's main job is to quickly localize each gamma-ray burst (GRB), report its position so that others...

  8. The Gamma-ray Universe through Fermi

    NASA Technical Reports Server (NTRS)

    Thompson, David J.

    2012-01-01

    Gamma rays, the most powerful form of light, reveal extreme conditions in the Universe. The Fermi Gamma-ray Space Telescope and its smaller cousin AGILE have been exploring the gamma-ray sky for several years, enabling a search for powerful transients like gamma-ray bursts, novae, solar flares, and flaring active galactic nuclei, as well as long-term studies including pulsars, binary systems, supernova remnants, and searches for predicted sources of gamma rays such as dark matter annihilation. Some results include a stringent limit on Lorentz invariance derived from a gamma-ray burst, unexpected gamma-ray variability from the Crab Nebula, a huge ga.nuna-ray structure associated with the center of our galaxy, surprising behavior from some gamma-ray binary systems, and a possible constraint on some WIMP models for dark matter.

  9. Portable compton gamma-ray detection system

    DOEpatents

    Rowland, Mark S.; Oldaker, Mark E.

    2008-03-04

    A Compton scattered gamma-ray detector system. The system comprises a gamma-ray spectrometer and an annular array of individual scintillators. The scintillators are positioned so that they are arrayed around the gamma-ray spectrometer. The annular array of individual scintillators includes a first scintillator. A radiation shield is positioned around the first scintillator. A multi-channel analyzer is operatively connected to the gamma-ray spectrometer and the annular array of individual scintillators.

  10. Gamma ray spectroscopy in astrophysics. [conferences

    NASA Technical Reports Server (NTRS)

    Cline, T. L. (Editor); Ramaty, R. (Editor)

    1978-01-01

    Experimental and theoretical aspects of gamma ray spectroscopy in high energy astrophysics are discussed. Line spectra from solar, stellar, planetary, and cosmic gamma rays are examined as well as HEAO investigations, the prospects of a gamma ray observatory, and follow-on X-ray experiments in space.

  11. Nuclear gamma rays from energetic particle interactions

    NASA Technical Reports Server (NTRS)

    Ramaty, R.; Kozlovsky, B.; Lingenfelter, R. E.

    1978-01-01

    Gamma ray line emission from nuclear deexcitation following energetic particle reactions is evaluated. The compiled nuclear data and the calculated gamma ray spectra and intensities can be used for the study of astrophysical sites which contain large fluxes of energetic protons and nuclei. A detailed evaluation of gamma ray line production in the interstellar medium is made.

  12. Evaluation of proposed hardness assurance method for bipolar linear circuits with enhanced low dose rate sensitivity (ELDRS)

    SciTech Connect

    Pease, R.L.; Gehlhausen, M.; Krieg, J.; Titus, J.; Turflinger, T.; Emily, D.; Cohn, L.

    1998-12-01

    Data are presented on several low dose rate sensitive bipolar linear circuits to evaluate a proposed hardness assurance method. The circuits include primarily operational amplifiers and voltage comparators with a variety of sensitive components and failure modes. The proposed method, presented in 1997, includes an option between a low dose rate test at 10 mrd(Si)/s and room temperature and a 100 C elevated temperature irradiation test at a moderate dose rate. The results of this evaluation demonstrate that a 10 mrd(Si)/s test is able (in all but one case) to bound the worst case response within a factor of 2. For the moderate dose rate, 100 C test the worst case response is within a factor of 3 for 8 of 11 circuits, and for some circuits overpredicts the low dose rate response. The irradiation bias used for these tests often represents a more degrading bias condition than would be encountered in a typical space system application.

  13. Evaluation of the MIM Symphony treatment planning system for low-dose-rate- prostate brachytherapy.

    PubMed

    Dhanesar, Sandeep K; Lim, Tze Y; Du, Weiliang; Bruno, Teresa L; Frank, Steven J; Kudchadker, Rajat J

    2015-09-08

    MIM Symphony is a recently introduced low-dose-rate prostate brachytherapy treatment planning system (TPS). We evaluated the dosimetric and planning accuracy of this new TPS compared to the universally used VariSeed TPS. For dosimetric evaluation of the MIM Symphony version 5.4 TPS, we compared dose calculations from the MIM Symphony TPS with the formalism recommended by the American Association of Physicists in Medicine Task Group 43 report (TG-43) and those generated by the VariSeed version 8.0 TPS for iodine-125 (I-125; Models 6711 and IAI-125A), palladium-103 (Pd-103; Model 200), and cesium-131 (Cs-131; Model Cs-1). Validation was performed for both line source and point source approximations. As part of the treatment planning validation, first a QA phantom (CIRS Brachytherapy QA Phantom Model 045 SN#D7210-3) containing three ellipsoid objects with certified volumes was scanned in order to check the volume accuracy of the contoured structures in MIM Symphony. Then the DICOM data containing 100 patient plans from the VariSeed TPS were imported into the MIM Symphony TPS. The 100 plans included 25 each of I-125 pre-implant plans, Pd-103 pre-implant plans, I-125 Day 30 plans (i.e., from 1 month after implantation), and Pd-103 Day 30 plans. The dosimetric parameters (including prostate volume, prostate D90 values, and rectum V100 values) of the 100 plans were calculated independently on the two TPSs. Other TPS tests that were done included verification of source input and geometrical accuracy, data transfer between different planning systems, text printout, 2D dose plots, DVH printout, and template grid accuracy. According to the line source formalism, the dosimetric results between the MIM Symphony TPS and TG-43 were within 0.5% (0.02 Gy) for r > 1 cm. In the line source approximation validation, MIM Symphony TPS values agreed with VariSeed TPS values to within 0.5% (0.09 Gy) for r > 1 cm. Similarly, in point source approximation validation, the MIM Symphony values

  14. High Dose-Rate Versus Low Dose-Rate Brachytherapy for Lip Cancer

    SciTech Connect

    Ghadjar, Pirus; Bojaxhiu, Beat; Simcock, Mathew; Terribilini, Dario; Isaak, Bernhard; Gut, Philipp; Wolfensberger, Patrick; Broemme, Jens O.; Geretschlaeger, Andreas; Behrensmeier, Frank; Pica, Alessia; Aebersold, Daniel M.

    2012-07-15

    Purpose: To analyze the outcome after low-dose-rate (LDR) or high-dose-rate (HDR) brachytherapy for lip cancer. Methods and Materials: One hundred and three patients with newly diagnosed squamous cell carcinoma of the lip were treated between March 1985 and June 2009 either by HDR (n = 33) or LDR brachytherapy (n = 70). Sixty-eight patients received brachytherapy alone, and 35 received tumor excision followed by brachytherapy because of positive resection margins. Acute and late toxicity was assessed according to the Common Terminology Criteria for Adverse Events 3.0. Results: Median follow-up was 3.1 years (range, 0.3-23 years). Clinical and pathological variables did not differ significantly between groups. At 5 years, local recurrence-free survival, regional recurrence-free survival, and overall survival rates were 93%, 90%, and 77%. There was no significant difference for these endpoints when HDR was compared with LDR brachytherapy. Forty-two of 103 patients (41%) experienced acute Grade 2 and 57 of 103 patients (55%) experienced acute Grade 3 toxicity. Late Grade 1 toxicity was experienced by 34 of 103 patients (33%), and 5 of 103 patients (5%) experienced late Grade 2 toxicity; no Grade 3 late toxicity was observed. Acute and late toxicity rates were not significantly different between HDR and LDR brachytherapy. Conclusions: As treatment for lip cancer, HDR and LDR brachytherapy have comparable locoregional control and acute and late toxicity rates. HDR brachytherapy for lip cancer seems to be an effective treatment with acceptable toxicity.

  15. Quality of Life of Oral Cancer Patients After Low-Dose-Rate Interstitial Brachytherapy

    SciTech Connect

    Yoshimura, Ryo-ichi Shibuya, Hitoshi; Miura, Masahiko; Watanabe, Hiroshi; Ayukawa, Fumio; Hayashi, Keiji; Toda, Kazuma

    2009-03-01

    Purpose: To assess the quality of life (QOL) of oral cancer patients treated with low-dose-rate interstitial brachytherapy (LDR-BT) alone. Methods and Materials: Between June 2005 and July 2006, a total of 56 patients with oral cancer were enrolled in this prospective study. QOL was assessed by means of the core questionnaire and head and neck questionnaire module of the European Organization for Research and Treatment of Cancer (EORTC Quality of Life Questionnaire-Core 30 [QLQ-C30] and QLQ Head and Neck 35 [H and N35]). The questionnaires were distributed to the patients before the start of treatment and 3 months, 6 months, and 12 months after the start of LDR-BT. Results: It was possible to analyze the results for 20 of the initial 56 patients because they did not experience metastasis or recurrence during this study. No functions or symptoms asked about in the QLQ-C30 deteriorated during the first year. The emotional function score steadily and significantly increased. No symptoms in the QLQ-H and N35 significantly deteriorated. The scores for pain, trouble with social eating, and weight loss on the QLQ-H and N35 steadily and significantly decreased. Age, gender, and LDR-BT source had no effect on the change in QOL during the first year, but T-stage significantly affected the change in global health status, tumor site affected the changes in swallowing, sensory problems, sticky saliva, and complications affected the changes in pain, swallowing, and mouth opening. Conclusions: QOL of oral cancer patients treated with LDR-BT is high. However, tumor stage, tumor site, and complications affected the changes in a few functions and symptoms during the first year.

  16. Megavoltage computed tomography image-based low-dose rate intracavitary brachytherapy planning for cervical carcinoma.

    PubMed

    Wagner, Thomas H; Langen, Katja M; Meeks, Sanford L; Willoughby, Twyla R; Zeidan, Omar A; Staton, Robert J; Shah, Amish P; Manon, Rafael R; Kupelian, Patrick A

    2009-04-01

    Initial results of megavoltage computed tomography (MVCT) brachytherapy treatment planning are presented, using a commercially available helical tomotherapy treatment unit and standard low dose rate (LDR) brachytherapy applicators used for treatment of cervical carcinoma. The accuracy of MVCT imaging techniques, and dosimetric accuracy of the CT based plans were tested with in-house and commercially-available phantoms. Three dimensional (3D) dose distributions were computed and compared to the two dimensional (2D) dosimetry results. Minimal doses received by the 2 cm3 of bladder and rectum receiving the highest doses (D(B2cc) and D(R2cc), respectively) were computed from dose-volume histograms and compared to the doses computed for the standard ICRU bladder and rectal reference dose points. Phantom test objects in MVCT image sets were localized with sub-millimetric accuracy, and the accuracy of the MVCT-based dose calculation was verified. Fifteen brachytherapy insertions were also analyzed. The ICRU rectal point dose did not differ significantly from D(R2cc) (p=0.749, mean difference was 24 cGy +/- 283 cGy). The ICRU bladder point dose was significantly lower than the D(B2cc) (p=0.024, mean difference was 291 cGy +/- 444 cGy). The median volumes of bladder and rectum receiving at least the corresponding ICRU reference point dose were 6.1 cm(3) and 2.0 cm(3), respectively. Our initial experience in using MVCT imaging for clinical LDR gynecological brachytherapy indicates that the MVCT images are of sufficient quality for use in 3D, MVCT-based dose planning.

  17. Overview of Radiosensitivity of Human Tumor Cells to Low-Dose-Rate Irradiation

    SciTech Connect

    Williams, Jerry R. Zhang Yonggang; Zhou Haoming; Gridley, Daila S.; Koch, Cameron J.; Slater, James M.; Little, John B.

    2008-11-01

    Purpose: We compared clonogenic survival in 27 human tumor cell lines that vary in genotype after low-dose-rate (LDR) or high-dose rate (HDR) irradiation. We measured susceptibility to LDR-induced redistribution in the cell cycle in eight of these cell lines. Methods and Materials: We measured clonogenic survival after up to 96 hours of LDR (0.25 Gy/h) irradiation. We compared these with clonogenic survival after HDR irradiation (50 Gy/h). Using flow cytometry, we measured LDR-induced redistribution as a function of time during LDR irradiation in eight of these cell lines. Results: Coefficients that describe clonogenic survival after both LDR and HDR irradiation segregate into four radiosensitivity groups that associate with cell genotype: mutant (mut)ATM, wild-type TP53, mutTP53, and an unidentified gene in radioresistant glioma cells. The LDR and HDR radiosensitivity correlates at lower doses ({approx}2 Gy HDR, {approx}6 Gy LDR), but not at higher doses (HDR > 4 Gy; LDR > 6 Gy). The rate of LDR-induced loss of clonogenic survival changes at approximately 24 hours; wild-type TP53 cells become more resistant and mutTP53 cells become more sensitive. Redistribution induced by LDR irradiation also changes at approximately 24 hours. Conclusions: Radiosensitivity of human tumor cells to both LDR and HDR irradiation is genotype dependent. Analysis of coefficients that describe cellular radiosensitivity segregates 27 cell lines into four statistically distinct groups, each associating with specific genotypes. Changes in cellular radiosensitivity and redistribution in the cell cycle are strongly time dependent. Our data establish a genotype-dependent time-dependent model that predicts clonogenic survival, explains the inverse dose-rate effect, and suggests possible clinical applications.

  18. Low-dose or low-dose-rate ionizing radiation–induced bioeffects in animal models

    PubMed Central

    Loke, Weng Keong; Khoo, Boo Cheong

    2017-01-01

    Abstract Animal experimental studies indicate that acute or chronic low-dose ionizing radiation (LDIR) (≤100 mSv) or low-dose-rate ionizing radiation (LDRIR) (<6 mSv/h) exposures may be harmful. It induces genetic and epigenetic changes and is associated with a range of physiological disturbances that includes altered immune system, abnormal brain development with resultant cognitive impairment, cataractogenesis, abnormal embryonic development, circulatory diseases, weight gain, premature menopause in female animals, tumorigenesis and shortened lifespan. Paternal or prenatal LDIR/LDRIR exposure is associated with reduced fertility and number of live fetuses, and transgenerational genomic aberrations. On the other hand, in some experimental studies, LDIR/LDRIR exposure has also been reported to bring about beneficial effects such as reduction in tumorigenesis, prolonged lifespan and enhanced fertility. The differences in reported effects of LDIR/LDRIR exposure are dependent on animal genetic background (susceptibility), age (prenatal or postnatal days), sex, nature of radiation exposure (i.e. acute, fractionated or chronic radiation exposure), type of radiation, combination of radiation with other toxic agents (such as smoking, pesticides or other chemical toxins) or animal experimental designs. In this review paper, we aimed to update radiation researchers and radiologists on the current progress achieved in understanding the LDIR/LDRIR-induced bionegative and biopositive effects reported in the various animal models. The roles played by a variety of molecules that are implicated in LDIR/LDRIR-induced health effects will be elaborated. The review will help in future investigations of LDIR/LDRIR-induced health effects by providing clues for designing improved animal research models in order to clarify the current controversial/contradictory findings from existing studies. PMID:28077626

  19. Low-dose-rate Brachytherapy for Prostate Cancer in Low-resource Settings.

    PubMed

    Echevarria, Michelle I; Naghavi, Arash O; Abuodeh, Yazan A; Ahmed, Kamran A; Chevere, Carlos; Fernandez, Daniel; Yamoah, Kosj

    2017-10-01

    In areas with limited health care, it is important to identify and implement effective treatment methods and to optimize available resources. We investigated the implementation of a low-dose-rate (LDR) brachytherapy program for the treatment of prostate cancer (PCa) in a low-resource setting such as Puerto Rico (PR), where PCa is the main cause of cancer-associated death. After institutional approval, the medical records of patients with nonmetastatic PCa undergoing LDR brachytherapy from 2008 to 2013 were reviewed from PR. The factors analyzed included adequate D90 (radiation dose delivered to 90% of the target volume) coverage (≥140 Gy), early and late toxicity (Common Terminology Criteria for Adverse Events grade >2), and prostate-specific antigen failure. Freedom from biochemical failure was evaluated using Kaplan-Meier analysis. The barriers to implementation of LDR brachytherapy in a country with limited resources were identified. These included lack of access to funding for startup costs, specific referral patterns, lack of trained support staff, such as dosimetrists and physicists, and initial opposition from insurance companies for reimbursement. The initial results from 191 patients were included in the present study with a median follow-up period of 26 months. Prostate-specific antigen failure occurred in 6 patients (3%). No early or late gastrointestinal toxicity (grade >2) developed. Only 3 (2%) and 2 (1%) patients experienced early and late genitourinary toxicity (grade >2), respectively. The 2- and 3-year freedom from biochemical failure in this population was 97% and 95.9%, respectively. At present, limited data are available delineating the barriers faced by low-resource settings in the implementation of LDR brachytherapy. Our data highlight the issues unique to this environment and support the use of LDR brachytherapy as a reliable and effective treatment modality for patients with PCa in low-resource settings. Copyright © 2017 Elsevier Inc

  20. Low-dose or low-dose-rate ionizing radiation-induced bioeffects in animal models.

    PubMed

    Tang, Feng Ru; Loke, Weng Keong; Khoo, Boo Cheong

    2017-03-01

    Animal experimental studies indicate that acute or chronic low-dose ionizing radiation (LDIR) (≤100 mSv) or low-dose-rate ionizing radiation (LDRIR) (<6 mSv/h) exposures may be harmful. It induces genetic and epigenetic changes and is associated with a range of physiological disturbances that includes altered immune system, abnormal brain development with resultant cognitive impairment, cataractogenesis, abnormal embryonic development, circulatory diseases, weight gain, premature menopause in female animals, tumorigenesis and shortened lifespan. Paternal or prenatal LDIR/LDRIR exposure is associated with reduced fertility and number of live fetuses, and transgenerational genomic aberrations. On the other hand, in some experimental studies, LDIR/LDRIR exposure has also been reported to bring about beneficial effects such as reduction in tumorigenesis, prolonged lifespan and enhanced fertility. The differences in reported effects of LDIR/LDRIR exposure are dependent on animal genetic background (susceptibility), age (prenatal or postnatal days), sex, nature of radiation exposure (i.e. acute, fractionated or chronic radiation exposure), type of radiation, combination of radiation with other toxic agents (such as smoking, pesticides or other chemical toxins) or animal experimental designs. In this review paper, we aimed to update radiation researchers and radiologists on the current progress achieved in understanding the LDIR/LDRIR-induced bionegative and biopositive effects reported in the various animal models. The roles played by a variety of molecules that are implicated in LDIR/LDRIR-induced health effects will be elaborated. The review will help in future investigations of LDIR/LDRIR-induced health effects by providing clues for designing improved animal research models in order to clarify the current controversial/contradictory findings from existing studies. © The Author 2017. Published by Oxford University Press on behalf of The Japan Radiation Research

  1. Effects of orientation of substrate on the enhanced low-dose-rate sensitivity (ELDRS) in NPN transistors

    NASA Astrophysics Data System (ADS)

    Lu, Wu; Zheng, Yu-Zhan; Wang, Yi-Yuan; Ren, Di-Yuan; Guo, Qi; Wang, Zhi-Kuan; Wang, Jian-An

    2011-02-01

    The radiation effects and annealing characteristics of two types of domestic NPN bipolar junction transistors, fabricated with different orientations, were investigated under different dose-rate irradiation. The experimental results show that both types of the NPN transistors exhibit remarkable Enhanced Low-Dose-Rate Sensitivity (ELDRS). After irradiation at high or low dose rate, the excess base current of NPN transistors obviously increased, and the current gain would degrade rapidly. Moreover, the decrease of collector current was also observed. The NPN transistor with <111> orientation was more sensitive to ionizing radiation than that with <100> orientation. The underlying mechanisms of various experimental phenomena are discussed in detail in this paper.

  2. Cosmic gamma-ray lines

    NASA Technical Reports Server (NTRS)

    Ramaty, R.; Lingenfelter, R. E.

    1986-01-01

    Recent observations of gamma-ray line emissions from gamma-ray bursts, the ISM, the Galactic center, and solar flares are reviewed, and the implications of these observations for high-energy processes in these sources are discussed. Line observations suggest that magnetized neutron stars are probably the best candidate objects for burst sources. Observations of the 1.809-MeV line from Al-26 decay provide evidence for ongoing nucleosynthesis in the Galaxy and information on the spatial distribution of nucleosynthetic sites. The compact 0.511-MeV line source is probably a black hole at or close to the Galactic center. Solar-flare studies have provided new information on the confinement and escape of charged particles at the sun and on multiple acceleration phases in solar flares.

  3. Terrestrial Gamma-Ray Flashes (TGFs)

    NASA Technical Reports Server (NTRS)

    Fishman, Gerald J.

    2010-01-01

    This slide presentation reviews the observation of Terrestrial Gamma Ray Flashes (TGFs) by Gamma-Ray Telescopes. These were: (1) BATSE /Compton Observatory, (2) Solar Spectroscopic Imager, (3) AGILE Gamma-ray Telescope, and (4) Gamma-ray Burst Monitor (GBM) on the Fermi Gamma-ray Space Telescope. It contains charts which display the counts over time, a map or the TGFs observed by the Reuven Ramaty High Energy Solar Spectroscopic Imager (RHESSI). and a map showing the latitude and longitude of 85 of the TGFs observed by the Fermi GBM.

  4. Compton Gamma Ray Observatory Guest Investigator Program

    NASA Technical Reports Server (NTRS)

    Lingenfelter, Richard E.

    1997-01-01

    This paper presents a final report for the Compton Gamma Ray Observatory Guest Investigator Program from 06/01/91-07/31/97. The topics include: 1) Solar Flare Neutron Spectra and Accelerated Ions; 2) Gamma Ray Lines From The Orion Complex; 3) Implications of Nuclear Line Emission From The Orion Complex; 4) Possible Sites of Nuclear Line Emission From Massive OB Associations; 5) Gamma-Ray Burst Repitition and BATSE Position Uncertainties; 6) Effects of Compton Scattering on BATSE Gamma-Ray Burst Spectra; and 7) Selection Biases on the Spectral and Temporal Distribution of Gamma Ray Bursts.

  5. The First Fermi Gamma-ray Burst Monitor (GBM) Terrestrial Gamma-ray Flash (TGF) Catalog

    NASA Astrophysics Data System (ADS)

    Briggs, Michael; Connaughton, Valerie; Stanbro, Matthew; Zhang, Binbin; Bhat, Narayana; Fishman, Gerald; Roberts, Oliver; Fitzpatrick, Gerard; McBreen, Shelia; Grove, Eric; Chekhtman, Alexandre

    2015-04-01

    We present summary results from the first catalog of Terrestrial Gamma-ray Flashes (TGFs) detected with the Gamma-ray Burst Monitor (GBM) on the Fermi Space Telescope. The catalog reports parameters for over 2700 TGFs. Since the launch of Fermi in 2008 the TGF detection sensitivity of GBM has been improved several times, both in the flight software and in ground analysis. Starting in 2010 July individual photons were downloaded for portions of the orbits, enabling an off-line search that found weaker and shorter TGFs. Since 2012 November 26 this telemetry mode has been extended to continuous coverage. The TGF sample is reliable, with cosmic rays rejected using data both from Fermi GBM and from the Large Area Telescope on Fermi. The online catalog include times (UTC and solar), spacecraft geographic positions, durations, count intensities and Bayesian Block durations. The catalog includes separate tables for bright TGFs detected by the flight software and for Terrestrial Electron Beams (TEBs).

  6. On the origin of gamma ray bursts

    NASA Astrophysics Data System (ADS)

    Vahia, M. N.; Rao, A. R.

    1988-03-01

    It is argued that observations of gamma ray bursts show that the neutron star model is not tenable. A similarity between gamma ray burst characteristics and solar hard X-ray flares is established. The temporal and spectral features observed in the gamma ray bursts are also seen in the solar hard X-ray flares. The only distinction is in the energy contents of the two. Gamma ray bursts may originate from sources which have Sun-like activity. Large scale Sun-like activity is observed in flare stars, RS CVn binaries, and cataclysmic variables, grouped together as magnetically active stellar systems. These systems have enough energy to produce gamma ray bursts. Positional identification between the gamma ray burst error boxes and the magnetically active stellar systems produces an association of 46 objects with 36 error boxes with a probability of chance coincidence of 10 to the minus 10th power. A gamma ray burst that has a spatial and temporal correlation to a soft X-ray flare associated with a magnetically active stellar system and another time coincidence where the gamma ray burst location is not known to be found. Gamma ray bursts should be considered the stellar equivalent of the solar hard X-ray burst. gamma ray burst location is not known are found. Gamma ray bursts should be considered as stellar equivalents of solar hard X-ray bursts.

  7. Common Gamma-ray Glows above Thunderclouds

    NASA Astrophysics Data System (ADS)

    Kelley, Nicole; Smith, David; Dwyer, Joseph; Hazelton, Bryna; Grefenstette, Brian; Lowell, Alex; Splitt, Michael; Lazarus, Steven; Rassoul, Hamid

    2013-04-01

    Gamma-ray glows are continuous, long duration gamma- and x-ray emission seen coming from thunderclouds. The Airborne for Energetic Lightning Emissions (ADELE) observed 12 gamma-ray glows during its summer 2009 flight campaign over the areas of Colorado and Florida in the United States. For these glows we shall present their spectra, relationship to lightning activity and how their duration and size changes as a function of distance. Gamma-ray glows follow the relativistic runaway electron avalanche (RREA) spectrum and have been previously measured from the ground and inside the cloud. ADELE measured most glows as it flew above the screening layer of the cloud. During the brightest glow on August 21, 2009, we can show that we are flying directly into a downward facing relativistic runaway avalanche, indicative of flying between the upper positive and negative screening layer of the cloud. In order to explain the brightness of this glow, RREA with an electric field approaching the limit for relativistic feedback must be occurring. Using all 12 glows, we show that lightning activity diminishes during the onset of the glow. Using this along with the fact that glows occur as the field approaches the level necessary for feedback, we attempt to distinguish between two possibilities: that glows are evidence that RREA with feedback, rather than lightning, is sometimes the primary channel for discharging the cloud, or else that the overall discharging is still controlled by lightning, with glows simply appearing during times when a subsidence of lightning allows the field to rise above the threshold for RREA.

  8. Color gamma ray camera: Laboratory directed research & development (LDRD) FY 1995

    SciTech Connect

    Bionta, R.M.

    1996-06-01

    Gamma-Ray imaging is a potentially powerful tool for the areas of arms-control, counter proliferation, safeguards and forensics. Combining spectral and spatial information increases the amount of information available for the detection and characterization of Special Nuclear Material (SNM). Two advanced gamma ray imaging technologies have been completed and are nearing completion at LLNL. These include the Gamma Ray Imaging System (GRIS), used to detect sub-600 keV gamma rays, and the Gamma Ray Bar Imaging Telescope (GRABIT), which extends the work of GRIS to larger areas and higher energies ({approximately}1000 keV). We proposed to continue work on a third, complementary type of detector, a Gamma Ray Color Camera (GRCC), which will incorporate spatial and spectral information from a gamma emitter.

  9. Multiwavelength Opportunities and Challenges in the Era of Fermi Gamma-ray Space Telescope Public Data

    NASA Astrophysics Data System (ADS)

    Thompson, David John; Fermi Large Area Telescope Collaboration

    2010-01-01

    The gamma-ray survey of the sky by the Fermi Gamma-ray Space Telescope offers both opportunities and challenges for multiwavelength and multi-messenger studies. Gamma-ray bursts, pulsars, binary sources, flaring Active Galactic Nuclei, and Galactic transient sources are all phenomena that can best be studied with a wide variety of instruments simultaneously or contemporaneously. Identification of newly-discovered gamma-ray sources is largely a multiwavelength effort. From the gamma-ray side, a principal challenge is the latency from the time of an astrophysical event to the recognition of this event in the data. Obtaining quick and complete multiwavelength coverage of gamma-ray sources can be difficult both in terms of logistics and in terms of generating scientific interest. The Fermi LAT team continues to welcome cooperative efforts aimed at maximizing the scientific return from the mission through multiwavelength studies.

  10. Investigation of pulsed low dose rate radiotherapy using dynamic arc delivery techniques

    NASA Astrophysics Data System (ADS)

    Ma, C.-M.; Lin, M. H.; Dai, X. F.; Koren, Sion; Klayton, T.; Wang, L.; Li, J. S.; Chen, L.; Price, R. A.

    2012-07-01

    There has been no consensus standard of care to treat recurrent cancer patients who have previously been irradiated. Pulsed low dose rate (PLDR) external beam radiotherapy has the potential to reduce normal tissue toxicities while still providing significant tumor control for recurrent cancers. This work investigates the dosimetry feasibility of PLDR treatment using dynamic arc delivery techniques. Five treatment sites were investigated in this study including breast, pancreas, prostate, head and neck, and lung. Dynamic arc plans were generated using the Varian Eclipse system and the RapidArc delivery technique with 6 and 10 MV photon beams. Each RapidArc plan consisted of two full arcs and the plan was delivered five times to achieve a daily dose of 200 cGy. The dosimetry requirement was to deliver approximately 20 cGy/arc with a 3 min interval to achieve an effective dose rate of 6.7 cGy min-1. Monte Carlo simulations were performed to calculate the actual dose delivered to the planning target volume (PTV) per arc taking into account beam attenuation/scattering and intensity modulation. The maximum, minimum and mean doses to the PTV were analyzed together with the dose volume histograms and isodose distributions. The dose delivery for the five plans was validated using solid water phantoms inserted with an ionization chamber and film, and a cylindrical detector array. Two intensity-modulated arcs were used to efficiently deliver the PLDR plans that provided conformal dose distributions for treating complex recurrent cancers. For the five treatment sites, the mean PTV dose ranged from 18.9 to 22.6 cGy/arc. For breast, the minimum and maximum PTV dose was 8.3 and 35.2 cGy/arc, respectively. The PTV dose varied between 12.9 and 27.5 cGy/arc for pancreas, 12.6 and 28.3 cGy/arc for prostate, 12.1 and 30.4 cGy/arc for H&N, and 16.2 and 27.6 cGy/arc for lung. Advanced radiation therapy can provide superior target coverage and normal tissue sparing for PLDR

  11. Chloroquine Improves Survival and Hematopoietic Recovery After Lethal Low-Dose-Rate Radiation

    SciTech Connect

    Lim Yiting; Hedayati, Mohammad; Merchant, Akil A.; Zhang Yonggang; Yu, Hsiang-Hsuan M.; Kastan, Michael B.; Matsui, William; DeWeese, Theodore L.

    2012-11-01

    Purpose: We have previously shown that the antimalarial agent chloroquine can abrogate the lethal cellular effects of low-dose-rate (LDR) radiation in vitro, most likely by activating the ataxia-telangiectasia mutated (ATM) protein. Here, we demonstrate that chloroquine treatment also protects against lethal doses of LDR radiation in vivo. Methods and Materials: C57BL/6 mice were irradiated with a total of 12.8 Gy delivered at 9.4 cGy/hour. ATM null mice from the same background were used to determine the influence of ATM. Chloroquine was administered by two intraperitoneal injections of 59.4 {mu}g per 17 g of body weight, 24 hours and 4 hours before irradiation. Bone marrow cells isolated from tibia, fibula, and vertebral bones were transplanted into lethally irradiated CD45 congenic recipient mice by retroorbital injection. Chimerism was assessed by flow cytometry. In vitro methylcellulose colony-forming assay of whole bone marrow cells and fluorescence activated cell sorting analysis of lineage depleted cells were used to assess the effect of chloroquine on progenitor cells. Results: Mice pretreated with chloroquine before radiation exhibited a significantly higher survival rate than did mice treated with radiation alone (80% vs. 31%, p = 0.0026). Chloroquine administration before radiation did not affect the survival of ATM null mice (p = 0.86). Chloroquine also had a significant effect on the early engraftment of bone marrow cells from the irradiated donor mice 6 weeks after transplantation (4.2% vs. 0.4%, p = 0.015). Conclusion: Chloroquine administration before radiation had a significant effect on the survival of normal but not ATM null mice, strongly suggesting that the in vivo effect, like the in vitro effect, is also ATM dependent. Chloroquine improved the early engraftment of bone marrow cells from LDR-irradiated mice, presumably by protecting the progenitor cells from radiation injury. Chloroquine thus could serve as a very useful drug for protection

  12. Low-Dose-Rate Brachytherapy Versus Cryotherapy in Low- and Intermediate-Risk Prostate Cancer.

    PubMed

    Gestaut, Matthew M; Cai, Wendi; Vyas, Shilpa; Patel, Belur J; Hasan, Salman A; MunozMaldonado, Yolanda; Deb, Niloyjyoti; Swanson, Gregory

    2017-05-01

    Cryotherapy and brachytherapy are definitive local treatment options for low- to intermediate-risk prostate cancer. There are both prospective and retrospective data for brachytherapy, but the use of cryotherapy has been limited primarily to single-institution retrospective studies. Currently, no published evidence has compared low-dose-rate brachytherapy versus cryotherapy. Institutional review board approval was obtained to conduct a retrospective chart review of consecutive patients treated at our institution from 1990 to 2012. For inclusion, patients must have received a prostate cancer diagnosis and have been considered to have low- to intermediate-risk disease according to the National Comprehensive Cancer Network criteria. All patients received brachytherapy or cryotherapy treatment. Disease specifics and failure details were collected for all patients. Failure was defined as prostate-specific antigen nadir +2 ng/mL. A total of 359 patients were analyzed. The groups comprised 50 low-risk cryotherapy (LRC), 92 intermediate-risk cryotherapy (IRC), 133 low-risk brachytherapy (LRB), and 84 intermediate-risk brachytherapy (IRB) patients. The median prostate-specific antigen follow-up periods were 85.6 months (LRC), 59.2 months (IRC), 74.9 months (LRB), and 59.8 months (IRB). The 5-year biochemical progression-free survival (bPFS) rate was 57.9% in the cryotherapy group versus 89.6% in the brachytherapy group (P<.0001). The 5-year bPFS rate was 70.0% (LRC), 51.4% (IRC), 89.4% (LRB), and 89.7% (IRB). The bPFS rate was significantly different between brachytherapy and cryotherapy for low- and intermediate-risk groups (P<.05). The mean nadir temperature reached for cryotherapy patients was -35°C (range, -96°C to -6°C). Cryotherapy used a median of 2 freeze-thaw cycles (range, 2-4 freeze-thaw cycles). Results from this study suggest that cryotherapy is inferior to brachytherapy for patients with low- to intermediate-risk prostate cancer. Patient selection

  13. Chloroquine improves survival and hematopoietic recovery following lethal low dose- rate radiation

    PubMed Central

    Lim, Yiting; Hedayati, Mohammad; Merchant, Akil A.; Zhang, Yonggang; Yu, Hsiang-Hsuan M; Kastan, Michael B.; Matsui, William; DeWeese, Theodore L.

    2012-01-01

    Purpose We have previously shown that the anti-malarial agent chloroquine can abrogate the lethal cellular effects of low dose-rate (LDR) radiation in vitro, most likely by activating the ataxia-telangiectasia mutated (ATM) protein. Here, we demonstrate that chloroquine treatment also protects against lethal doses of LDR radiation in vivo. Methods and Materials C57BL/6 mice were irradiated with total of 12.8 Gy delivered at 9.4 cGy/hr. ATM null mice from the same background were used to determine the influence of ATM. Chloroquine was administered by two intraperitoneal injections of 59.4 μg per 17 g of body weight, 24 hrs and 4 hrs before irradiation. Bone marrow cells isolated from tibia, fibula and vertebral bones were transplanted into lethally irradiated CD45 congenic recipient mice by retro orbital injection. Chimerism was assessed by flow cytometry. In vitro methyl cellulose colony forming assay of whole bone marrow cells as well as FACS analysis of lineage depleted cells was used to assess the effect of chloroquine on progenitor cells. Results Mice pretreated with chloroquine prior to radiation exhibited a significantly higher survival rate compared to mice treated with radiation alone (80 vs.31 percent, p=0.0026). Chloroquine administration prior to radiation did not impact the survival of ATM null mice (p=0.86). Chloroquine also had a significant effect on the early engraftment of bone marrow cells from the irradiated donor mice 6 weeks after the transplantation (4.2 percent vs. 0.4 percent, p=0.015). Conclusion Chloroquine administration prior to radiation had a significant effect on the survival of normal but not ATM null mice strongly suggesting that the in vivo effect like the in vitro effect is also ATM dependent. Chloroquine improved the early engraftment of bone marrow cells from LDR irradiated mice, presumably by protecting the progenitor cells from radiation injury. Chloroquine thus could serve as a very useful drug for protection against the

  14. Evaluation of High Performance Converters Under Low Dose Rate Total Ionizing Dose (TID) Testing for NASA Programs

    NASA Technical Reports Server (NTRS)

    Sharma, Ashok K.; Sahu, Kusum

    1998-01-01

    This paper reports the results of low dose rate (0.01-0.18 rads(Si)/sec) total ionizing dose (TID) tests performed on several types of high performance converters. The parts used in this evaluation represented devices such as a high speed flash converter, a 16-bit ADC and a voltage-to-frequency converter.

  15. Lack of therapeutic gain when low dose rate interstitial radiotherapy is combined with cisplatin in an animal tumour model.

    PubMed

    Pop, L; Levendag, P; van Geel, C; Deurloo, I K; Visser, A

    1992-01-01

    The interaction of cisplatin with low dose rate interstitial radiotherapy was studied in an animal tumour model with a range of dose rats commonly used in clinical low dose rate brachytherapy. Small pieces of R1-rhabdomyosarcoma were implanted subcutaneously in the flanks of female Wag/Rij rats. When the tumour had grown to the desired treatment volume, four afterloading catheters were inserted in the tumour in a square geometry, and a fixed spacing was attained by means of a template. Subsequently, four 2 cm Ir192 wires were inserted. A range of tumour doses of 20-120 Gy at a mean dose rate of 48 cGy/h was applied; 15 mins before the implant an intraperitoneal bolus injection of 3 mg/kg cisplatin was given. For growth delay and cure rate, no modification of the effects of low dose rate brachytherapy by the addition of cisplatin was observed. The observed effects of the combination of cisplatin with low dose rate interstitial radiation in relation to the animal tumour are discussed.

  16. Radiosensitization of Human Cervical Cancer Cells by Inhibiting Ribonucleotide Reductase: Enhanced Radiation Response at Low-Dose Rates

    SciTech Connect

    Kunos, Charles A.; Colussi, Valdir C.; Pink, John; Radivoyevitch, Tomas; Oleinick, Nancy L.

    2011-07-15

    Purpose: To test whether pharmacologic inhibition of ribonucleotide reductase (RNR) by 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, NSC no. 663249) enhances radiation sensitivity during low-dose-rate ionizing radiation provided by a novel purpose-built iridium-192 cell irradiator. Methods and Materials: The cells were exposed to low-dose-rate radiation (11, 23, 37, 67 cGy/h) using a custom-fabricated cell irradiator or to high-dose-rate radiation (330 cGy/min) using a conventional cell irradiator. The radiation sensitivity of human cervical (CaSki, C33-a) cancer cells with or without RNR inhibition by 3-AP was evaluated using a clonogenic survival and an RNR activity assay. Alteration in the cell cycle distribution was monitored using flow cytometry. Results: Increasing radiation sensitivity of both CaSki and C33-a cells was observed with the incremental increase in radiation dose rates. 3-AP treatment led to enhanced radiation sensitivity in both cell lines, eliminating differences in cell cytotoxicity from the radiation dose rate. RNR blockade by 3-AP during low-dose-rate irradiation was associated with low RNR activity and extended G{sub 1}-phase cell cycle arrest. Conclusions: We conclude that RNR inhibition by 3-AP impedes DNA damage repair mechanisms that rely on deoxyribonucleotide production and thereby increases radiation sensitivity of human cervical cancers to low-dose-rate radiation.

  17. Fermi Gamma-Ray Space Telescope Science Overview

    NASA Technical Reports Server (NTRS)

    Thompson, David J.

    2010-01-01

    After more than 2 years of science operations, the Fermi Gamma-ray Space Telescope continues to survey the high-energy sky on a daily basis. In addition to the more than 1400 sources found in the first Fermi Large Area Telescope Catalog (I FGL), new results continue to emerge. Some of these are: (1) Large-scale diffuse emission suggests possible activity from the Galactic Center region in the past; (2) a gamma-ray nova was found, indicating particle acceleration in this binary system; and (3) the Crab Nebula, long thought to be a steady source, has varied in the energy ranges seen by both Fermi instruments.

  18. Radiation Dose Predicts for Biochemical Control in Intermediate-Risk Prostate Cancer Patients Treated With Low-Dose-Rate Brachytherapy

    SciTech Connect

    Ho, Alice Y.; Burri, Ryan J.; Cesaretti, Jamie A.; Stone, Nelson N.; Stock, Richard G.

    2009-09-01

    Purpose: To evaluate the influence of patient- and treatment-related factors on freedom from biochemical failure (FFbF) in patients with intermediate-risk prostate cancer. Methods and Materials: From a prospectively collected database of 2250 men treated at Mount Sinai Hospital from 1990 to 2004 with low-dose-rate brachytherapy for prostate cancer, 558 men with either one or more intermediate-risk features (prostate-specific antigen [PSA] level 10-20 ng/mL, Gleason score 7, or Stage T2b) were identified who had a minimum follow-up of 24 months and postimplant CT-based dosimetric analysis. Biologically effective dose (BED) values were calculated to compare doses from different isotopes and treatment regimens. Patients were treated with brachytherapy with or without hormone therapy and/or external-beam radiotherapy. Patient- and treatment-related factors were analyzed with respect to FFbF. The median follow-up was 60 months (range, 24-167 months). Biochemical failure was defined according to the Phoenix definition. Univariate analyses were used to determine whether any variable was predictive of FFbF. A two-sided p value of <0.05 was considered significant. Results: Overall, the actuarial FFbF at 10 years was 86%. Dose (BED <150 Gy{sub 2} vs. {>=}150 Gy{sub 2}) was the only significant predictor of FFbF (p < 0.001). None of the other variables (PSA, external-beam radiotherapy, Gleason score, treatment type, hormones, stage, and number of risk factors) was found to be a statistically significant predictor of 10-year FFbF. Conclusions: Radiation dose is an important predictor of FFbF in intermediate-risk prostate cancer. Treatment should continue to be individualized according to presenting disease characteristics until results from Radiation Therapy Oncology Group trial 0232 become available.

  19. Gamma-ray astronomy: Nuclear transition region

    NASA Technical Reports Server (NTRS)

    Chupp, E. L.

    1976-01-01

    This monograph reviews the major theoretical and experimental efforts made during the past 12 years in gamma-ray astronomy over the energy range from 10 keV to about 100 MeV, where nuclear-transition lines are expected. Early attempts to detect celestial gamma rays are recounted, mechanisms of gamma-ray line and continuum production are examined, and formulas giving the various possible differential gamma-ray spectral shapes are provided. Predicted fluxes are discussed for solar gamma rays as well as for gamma emission from supernova remnants, supernovae, neutron stars, flare stars, the galactic core and disk, black holes, and diffuse sources. Gamma-ray interactions with matter are analyzed, particularly the photoelectric effect, Compton scattering from free electrons, and pair production in nuclear fields. Significant results are summarized for observations of gamma rays from the sun as well as from point and extended sources within and beyond the Galaxy, including diffuse fluxes and transient gamma-ray bursts. Factors pertaining to the design of gamma-ray astronomy experiments are considered, especially detector background limitations, gamma-ray production within instruments, and present-day detection methods.

  20. Gamma-ray astronomy: Nuclear transition region

    NASA Technical Reports Server (NTRS)

    Chupp, E. L.

    1976-01-01

    This monograph reviews the major theoretical and experimental efforts made during the past 12 years in gamma-ray astronomy over the energy range from 10 keV to about 100 MeV, where nuclear-transition lines are expected. Early attempts to detect celestial gamma rays are recounted, mechanisms of gamma-ray line and continuum production are examined, and formulas giving the various possible differential gamma-ray spectral shapes are provided. Predicted fluxes are discussed for solar gamma rays as well as for gamma emission from supernova remnants, supernovae, neutron stars, flare stars, the galactic core and disk, black holes, and diffuse sources. Gamma-ray interactions with matter are analyzed, particularly the photoelectric effect, Compton scattering from free electrons, and pair production in nuclear fields. Significant results are summarized for observations of gamma rays from the sun as well as from point and extended sources within and beyond the Galaxy, including diffuse fluxes and transient gamma-ray bursts. Factors pertaining to the design of gamma-ray astronomy experiments are considered, especially detector background limitations, gamma-ray production within instruments, and present-day detection methods.

  1. Air shower detectors in gamma-ray astronomy

    SciTech Connect

    Sinnis, Gus

    2008-01-01

    Extensive air shower (EAS) arrays directly detect the particles in an EAS that reach the observation altitude. This detection technique effectively makes air shower arrays synoptic telescopes -- they are capable of simultaneously and continuously viewing the entire overhead sky. Typical air shower detectors have an effective field-of-view of 2 sr and operate nearly 100% of the time. These two characteristics make them ideal instruments for studying the highest energy gamma rays, extended sources and transient phenomena. Until recently air shower arrays have had insufficient sensitivity to detect gamma-ray sources. Over the past decade, the situation has changed markedly. Milagro, in the US, and the Tibet AS{gamma} array in Tibet, have detected very-high-energy gamma-ray emission from the Crab Nebula and the active galaxy Markarian 421 (both previously known sources). Milagro has discovered TeV diffuse emission from the Milky Way, three unidentified sources of TeV gamma rays, and several candidate sources of TeV gamma rays. Given these successes and the suite of existing and planned instruments in the GeV and TeV regime (AGILE, GLAST, HESS, VERITAS, CTA, AGIS and IceCube) there are strong reasons for pursuing a next generation of EAS detectors. In conjunction with these other instruments the next generation of EAS instruments could answer long-standing problems in astrophysics.

  2. Genetic Factors Affecting Susceptibility to Low Dose & Low Dose-Rate Radiation

    SciTech Connect

    Bedford, Joel

    2014-04-18

    Our laboratory has, among other things, developed and used the gamma H2AX focus assay and other chromosomal and cell killing assays to show that differences in this DNA double strand break (dsb) related response can be clearly and distinctly demonstrated for cells which are mildly hyper-radiosensitive such as those associated with A-T heterozygosity. We have found this level of mild hypersensitivity for cells from some 20 to 30 % of apparently normal individuals and from apparently normal parents of Retinoblastoma patients. We found significant differences in gene expression in somatic cells from unaffected parents of Rb patients as compared with normal controls, suggesting that these parents may harbor some as yet unidentified genetic abnormality. In other experiments we sought to determine the extent of differences in normal human cellular reaponses to radiation depending on their irradiation in 2D monolayer vs 3D organized acinar growth conditions. We exmined cell reproductive death, chromosomal aberration induction, and the levels of γ-H2AX foci in cells after single acute gamma-ray doses and immediately after 20 hours of irradiation at a dose rate of 0.0017 Gy/min. We found no significant differences in the dose-responses of these cells under the 2D or 3D growth conditions. While this does not mean such differences cannot occur in other situations, it does mean that they do not generally or necessarily occur. In another series of studies in collaboration with Dr Chuan Li, with supprt from this current grant. We reported a role for apoptotic cell death in promoting wound healing and tissue regeneration in mice. Apoptotic cells released growth signals that stimulated the proliferation of progenitor or stem cells. In yet another collaboration with Dr, B. Chen with funds from this grant, the relative radiosensitivity to cell killing as well as chromosomal instability of 13 DNA-PKcs site-directed mutant cell lines (defective at phosphorylation sites or kinase

  3. Development of gamma ray imaging cameras

    SciTech Connect

    Wehe, D.K.; Knoll, G.F.

    1992-05-28

    In January 1990, the Department of Energy initiated this project with the objective to develop the technology for general purpose, portable gamma ray imaging cameras useful to the nuclear industry. The ultimate goal of this R D initiative is to develop the analog to the color television camera where the camera would respond to gamma rays instead of visible photons. The two-dimensional real-time image would be displayed would indicate the geometric location of the radiation relative to the camera's orientation, while the brightness and color'' would indicate the intensity and energy of the radiation (and hence identify the emitting isotope). There is a strong motivation for developing such a device for applications within the nuclear industry, for both high- and low-level waste repositories, for environmental restoration problems, and for space and fusion applications. At present, there are no general purpose radiation cameras capable of producing spectral images for such practical applications. At the time of this writing, work on this project has been underway for almost 18 months. Substantial progress has been made in the project's two primary areas: mechanically-collimated (MCC) and electronically-collimated camera (ECC) designs. We present developments covering the mechanically-collimated design, and then discuss the efforts on the electronically-collimated camera. The renewal proposal addresses the continuing R D efforts for the third year effort. 8 refs.

  4. Development of gamma ray imaging cameras

    NASA Astrophysics Data System (ADS)

    Wehe, D. K.; Knoll, G. F.

    1992-05-01

    In January 1990, the Department of Energy initiated this project with the objective to develop the technology for general purpose, portable gamma ray imaging cameras useful to the nuclear industry. The ultimate goal of this R&D initiative is to develop the analog to the color television camera where the camera would respond to gamma rays instead of visible photons. The two-dimensional real-time image would be displayed and indicate the geometric location of the radiation relative to the camera's orientation, while the brightness and 'color' would indicate the intensity and energy of the radiation and, hence, identify the emitting isotope. There is a strong motivation for developing such a device for applications within the nuclear industry, for both high- and low-level waste repositories, for environmental restoration problems, and for space and fusion applications. At present, there are no general purpose radiation cameras capable of producing spectral images for such practical applications. At the time of this writing, work on this project has been underway for almost 18 months. Substantial progress has been made in the project's two primary areas: mechanically-collimated (MCC) and electronically-collimated camera (ECC) designs. We present developments covering the mechanically-collimated design, and then discuss the efforts on the electronically-collimated camera. The renewal proposal addresses the continuing R&D efforts for the third year effort.

  5. Very high energy gamma ray astrophysics

    SciTech Connect

    Lamb, R.C.; Lewis, D.A.

    1992-02-01

    The second reflector (project GRANITE) is on schedule. At present (January 1992) it and the 10 m reflector are obtaining stereoscopic views of gamma-ray air showers from the Crab Nebula which verify the expected performance of the twin reflector telescopes. With the additional improvements of the upgrade (a pending DOE proposal) the twin reflectors should reach a limiting intensity of 1% that of the Crab. The astonishing early results from the EGRET detector aboard the Compton Gamma Ray Observatory indicate that distant quasars (powered by supermassive black holes) are active at GeV energies. The Whipple instruments are poised to see if such behavior continues above 100 GeV, as well as perform sensitive observations of previously reported GeV (Geminga) and TeV (Hercules X-1, etc.) sources. In addition to observing sources and identifying their location in the sky to one arcminute, experiments are planned to search for WIMPS in the mass range 0.1 to 1 TeV, and to determine the abundance of anti-protons in the cosmic rays. The successful performance of the stereoscopic reflectors demonstrates the feasibility of the concept of arrays of Cherenkov receivers. Design studies for a much larger array (CASITA) are just beginning.

  6. Spectra of {gamma} rays feeding superdeformed bands

    SciTech Connect

    Lauritsen, T.; Khoo, T.L.; Henry, R.G.

    1995-08-01

    The spectrum of {gamma}rays coincident with SD transitions contains the transitions which populate the SD band. This spectrum can provide information on the feeding mechanism and on the properties (moment of inertia, collectivity) of excited SD states. We used a model we developed to explain the feeding of SD bands, to calculate the spectrum of feeding {gamma}rays. The Monte Carlo simulations take into account the trigger conditions present in our Eurogam experiment. Both experimental and theoretical spectra contain a statistical component and a broad E2 peak (from transitions occurring between excited states in the SD well). There is good resemblance between the measured and calculated spectra although the calculated multiplicity of an E2 bump is low by {approximately}30%. Work is continuing to improve the quality of the fits, which will result in a better understanding of excited SD states. In addition, a model for the last steps, which cool the {gamma} cascade into the SD yrast line, needs to be developed. A strong M1/E2 low-energy component, which we believe is responsible for this cooling, was observed.

  7. Gamma ray observatory productivity showcase

    NASA Technical Reports Server (NTRS)

    Davis, R. L.; Molgaard, D. A.

    1985-01-01

    The Gamma Ray Observatory (GRO) Program has been proclaimed to be the showcase productivity program for NASA and TRW. Among the multiple disciplines of a large-scale program, there is opportunity and need for improved efficiency, effectiveness, and reduction in the cost of doing business. The efforts and tools that will or have been implemented to achieve this end are described. Since the GRO Program is mainly an engineering program with the build of one satellite, the primary emphasis is placed on improving the efficiency and quality of management and engineering.

  8. Gamma-Ray Bursts in the Swift Era

    NASA Technical Reports Server (NTRS)

    Gehrels, Neil; Ramirez-Ruiz, E.; Fox, D. B.

    2010-01-01

    With its rapid-response capability and multiwavelength complement of instruments, the Swift satellite has transformed our physical understanding of gamma-ray bursts. Providing high-quality observations of hundreds of bursts, and facilitating a wide range of follow-up observations within seconds of each event, Swift has revealed an unforeseen richness in observed burst properties, shed light on the nature of short-duration bursts, and helped realize the promise of gamma-ray bursts as probes of the processes and environments of star formation out to the earliest cosmic epochs. These advances have opened new perspectives on the nature and properties of burst central engines, interactions with the burst environment from microparsec to gigaparsec scales, and the possibilities for non-photonic signatures. Our understanding of these extreme cosmic sources has thus advanced substantially; yet more than forty years after their discovery, gamma-ray bursts continue to present major challenges on both observational and theoretical fronts.

  9. The Fermi Gamma-Ray Space Telescope

    NASA Technical Reports Server (NTRS)

    Thompson, Dave; McEnery, Julie

    2011-01-01

    This slide presentation reviews the Gamma Ray Astronomy as enhanced by the Fermi Gamma Ray Space Telescope and Radio Astronomy as a synergistic relationship. Gamma rays often represent a significant part of the energy budget of a source; therefore, gamma-ray studies can be critical to understanding physical processes in such sources. Radio observations offer timing and spatial resolutions vastly superior to anything possible with gamma-ray telescopes; therefore radio is often the key to understanding source structure. Gamma-ray and radio observations can complement each other, making a great team. It reviews the Fermi Guest Investigator (GI) program, and calls for more cooperative work that involves Fermi and the Very Long Baseline Array (VLBA), a system of ten radio telescopes.

  10. GAMCIT: A gamma ray burst detector

    NASA Technical Reports Server (NTRS)

    Surka, Derek M.; Grunsfeld, John M.; Warneke, Brett A.

    1992-01-01

    The origin of celestial gamma ray bursts remains one of the great mysteries of modern astrophysics. The GAMCIT Get-Away-Special payload is designed to provide new and unique data in the search for the sources of gamma ray bursts. GAMCIT consists of three gamma ray detectors, an optical CCD camera, and an intelligent electronics system. This paper describes the major components of the system, including the electronics and structural designs.

  11. Gamma-Ray Astronomy Technology Needs

    NASA Technical Reports Server (NTRS)

    Gehrels, N.; Cannizzo, J. K.

    2012-01-01

    In recent decades gamma-ray observations have become a valuable tool for studying the universe. Progress made in diverse 8re1lS such as gamma-ray bursts (GRBs), nucleosynthesis, and active galactic nuclei (AGNs) has complimented and enriched our astrophysical understanding in many ways. We present an overview of current and future planned space y-ray missions and discussion technology needs for- the next generation of space gamma-ray instruments.

  12. Understanding Doppler Broadening of Gamma Rays

    SciTech Connect

    Rawool-Sullivan, Mohini; Sullivan, John P.

    2014-07-03

    Doppler-broadened gamma ray peaks are observed routinely in the collection and analysis of gamma-ray spectra. If not recognized and understood, the appearance of Doppler broadening can complicate the interpretation of a spectrum and the correct identification of the gamma ray-emitting material. We have conducted a study using a simulation code to demonstrate how Doppler broadening arises and provide a real-world example in which Doppler broadening is found. This report describes that study and its results.

  13. Response to pulsed dose rate and low dose rate irradiation with and without mild hyperthermia using human breast carcinoma cell lines.

    PubMed

    Niedbala, M; McNamee, J P; Raaphorst, G P

    2006-02-01

    The purpose of this study was to establish whether a pulsed dose rate (PDR) treatment of 1.5 Gy given every 3 h in combination with 41 degrees C mild hyperthermia or a continuous low dose rate (LDR) treatment with mild hyperthermia could radiosensitize two isogenic human breast carcinoma cell lines in comparison to pulsed dose rate or low dose rate irradiation alone. The radiation resistant cell line was derived from the parental cell line and was transfected to over-express DNA polymerase beta. The end-points assessed were the survival of the cells using the clonogenic assay, the amount of residual DSB(s) using the comet assay and gene expression of polymerase beta using RT-PCR. Results showed that the PDR and LDR treatments combined with mild hyperthermia caused significant radiosensitization when compared to PDR and LDR irradiation alone in terms of the clonogenic and comet assays with both cell lines. RT-PCR results showed that polymerase beta levels of expression were not elevated in response to these treatments, implying that this polymerase may not be involved in sub-lethal damage repair or thermal radiosensitization. These results suggest a potential clinical advantage when combining LDR or PDR with hyperthermia, since they indicate that hyperthermia is an effective radiosensitizer.

  14. Gamma ray bursts inner engines

    NASA Astrophysics Data System (ADS)

    Staff, Jan Erling

    Long gamma ray bursts (GRBs) are brief durations of intense, highly variable gamma radiation coming from point like sources in the Universe. GRBs have been seen in connection with Type 1c supernovae. Their isotropical equivalent energy released in gamma rays is in some cases above 10 54 erg, but the engine creating this energy is unknown. In this thesis several models for the engine are explored. It is shown that cannonballs can in principle form from hyperaccreting disks, however the cannonball model requires almost all supernovae to create cannonballs, and our finding then implies that a hyperaccreting disk is a natural consequence in most supernovae, a notion which remains to be confirmed. General relativistic magnetohydrodynamic simulations of the collapsar model have been performed. Within our setup we found that the duration of the collapsar is too short to explain GRBs, and the energy output is not sufficient. Also the supernova connection could not be explained. I find that the more likely candidate for the GRB engine is an accreting quark star. A quark star has a maximum mass, if the mass increases above this the star will collapse to a black hole. This allows for a two stage engine that might be able to explain features observed in GRBs.

  15. Gamma-ray burst populations

    NASA Astrophysics Data System (ADS)

    Virgili, Francisco Javier

    Over the last fifty years the field of gamma-ray bursts has shown incredible growth, but the amassing of data has also left observers and theorists alike wondering about some of the basic questions surrounding these phenomena. Additionally, these events show remarkable individuality and extrema, ranging in redshift throughout the observable universe and over ten orders of magnitude in energy. This work focuses on analyzing groups of bursts that are different from the general trend and trying to understand whether these bursts are from different intrinsic populations and if so, what can be said about their progenitors. This is achieved through numerical Monte Carlo simulations and statistical inference in conjunction with current GRB observations. Chapter 1 gives a general introduction of gamma-ray burst theory and observations in a semi-historical context. Chapter 2 provides an introduction to the theory and practical issues surrounding the numerical simulations and statistics. Chapters 3--5 are each dedicated to a specific problem relating to a different type of GRB population: high-luminosity v. low-luminosity bursts, constraints from high-redshift bursts, and Type I v. Type II bursts. Chapter 6 follows with concluding remarks.

  16. Dark gamma-ray bursts

    NASA Astrophysics Data System (ADS)

    Brdar, Vedran; Kopp, Joachim; Liu, Jia

    2017-03-01

    Many theories of dark matter (DM) predict that DM particles can be captured by stars via scattering on ordinary matter. They subsequently condense into a DM core close to the center of the star and eventually annihilate. In this work, we trace DM capture and annihilation rates throughout the life of a massive star and show that this evolution culminates in an intense annihilation burst coincident with the death of the star in a core collapse supernova. The reason is that, along with the stellar interior, also its DM core heats up and contracts, so that the DM density increases rapidly during the final stages of stellar evolution. We argue that, counterintuitively, the annihilation burst is more intense if DM annihilation is a p -wave process than for s -wave annihilation because in the former case, more DM particles survive until the supernova. If among the DM annihilation products are particles like dark photons that can escape the exploding star and decay to standard model particles later, the annihilation burst results in a flash of gamma rays accompanying the supernova. For a galactic supernova, this "dark gamma-ray burst" may be observable in the Čerenkov Telescope Array.

  17. Hard gamma ray emission from blazars

    NASA Technical Reports Server (NTRS)

    Marscher, Alan P.; Bloom, Steven D.

    1992-01-01

    The gamma-ray emission expected from compact extragalactic sources of nonthermal radiation is examined. The highly variable objects in this class should produce copious amounts of self-Compton gamma-rays in the compact relativistic jet. This is shown to be a likely interpretation of the hard gamma-ray emission recently detected from the quasar 3C 279 during a period of strong nonthermal flaring at lower frequencies. Ways of discriminating between the self-Compton model and other possible gamma-ray emission mechanisms are discussed.

  18. Gamma-ray irradiated polymer optical waveguides

    SciTech Connect

    Lai, C.-C.; Wei, T.-Y.; Chang, C.-Y.; Wang, W.-S.; Wei, Y.-Y.

    2008-01-14

    Optical waveguides fabricated by gamma-ray irradiation on polymer through a gold mask are presented. The gamma-ray induced index change is found almost linearly dependent on the dose of the irradiation. And the measured propagation losses are low enough for practical application. Due to the high penetrability of gamma ray, uniform refractive index change in depth can be easily achieved. Moreover, due to large-area printing, the uniformity of waveguide made by gamma-ray irradiation is much better than that by e-beam direct writing.

  19. Low-level gamma-ray spectrometry

    SciTech Connect

    Brodzinski, R.L.

    1990-10-01

    Low-level gamma-ray spectrometry generally equates to high-sensitivity gamma-ray spectrometry that can be attained by background reduction, selective signal identification, or some combination of both. Various methods for selectively identifying gamma-ray events and for reducing the background in gamma-ray spectrometers are given. The relative magnitude of each effect on overall sensitivity and the relative cost'' for implementing them are given so that a cost/benefit comparison can be made and a sufficiently sensitive spectrometer system can be designed for any application without going to excessive or unnecessary expense. 10 refs., 8 figs.

  20. The Mystery of Gamma-Ray Bursts

    NASA Technical Reports Server (NTRS)

    Fishman, Gerald J.

    2004-01-01

    Gamma-ray bursts remain one of the greatest mysteries in astrophysics. Observations of gamma-ray bursts made by the BATSE experiment on the Compton Gamma-Ray Observatory will be described. Most workers in the field now believe that they originate from cosmological distances. This view has been reinforced by observations this year of several optical afterglow counterparts to gamma-ray bursts. A summary of these recent discoveries will be presented, along with their implications for models of the burst emission mechanism and the energy source of the bursts.

  1. Future prospects for gamma-ray

    NASA Technical Reports Server (NTRS)

    Fichtel, C.

    1980-01-01

    Astrophysical phenomena discussed are: the very energetic and nuclear processes associated with compact objects; astrophysical nucleo-synthesis; solar particle acceleration; the chemical composition of the planets and other bodies of the solar system; the structure of our galaxy; the origin and dynamic pressure effects of the cosmic rays; the high energy particles and energetic processes in other galaxies, especially active ones; and the degree of matter antimater symmetry of the universe. The gamma ray results of GAMMA-I, the gamma ray observatory, the gamma ray burst network, solar polar, and very high energy gamma ray telescopes on the ground provide justification for more sophisticated telescopes.

  2. [Low-dose rate brachytherapy with locally integrated beta emitters after internal urethrotomy. A pilot project using an animal model].

    PubMed

    Weidlich, P; Adam, C; Sroka, R; Lanzl, I; Assmann, W; Stief, C

    2007-09-01

    The treatment of urethral strictures represents an unsolved urological problem. The effect of a (32)P-coated urethral catheter in the sense of low-dose rate brachytherapy to modulate wound healing will be analyzed in an animal experiment. Unfortunately it is not possible to present any results because this is being studied for the first time and there are no experiences with low-dose rate brachytherapy and this form of application in the lower urinary tract. Furthermore the animal experiment will only start in the near future. Both decade-long experiences with radiotherapy to treat benign diseases and our own results of previous studies in otolaryngology and ophthalmology let us expect a significantly lower formation of urethral strictures after internal urethrotomy. This study will contribute to improving the treatment of urethral strictures as demanded in previous papers.

  3. First observations of enhanced low dose rate sensitivity (ELDRS) in space: One part of the MPTB experiment

    SciTech Connect

    Titus, J.L.; Combs, W.E.; Turflinger, T.L.; Krieg, J.F.; Tausch, H.J.; Brown, D.B.; Campbell, A.B.; Pease, R.L.

    1998-12-01

    Bipolar devices, most notably circuits fabricated with lateral PNP transistors (LPNP) and substrate PNP transistors (SPNP), have been observed to exhibit an enhanced low dose rate sensitivity when exposed to ionizing radiation. These dose rate sensitive bipolar devices exhibited enhanced degradation of base current in transistors and of input bias current, offset current, and/or offset voltage in linear circuits at dose rates greater than 1 rd(Si)/s. The total dose responses of several bipolar transistors and linear circuits in a space environment are demonstrated to exhibit enhanced degradation comparable, in magnitude, to ground-based data irradiated at a dose rate of 10 mrd(Si)/s indicating that enhanced low dose rate sensitivities (ELDRS) do indeed exist in space.

  4. Calibration of the Energetic Gamma-Ray Experiment Telescope (EGRET) for the Compton Gamma-Ray Observatory

    NASA Technical Reports Server (NTRS)

    Thompson, D. J.; Bertsch, D. L.; Fichtel, C. E.; Hartman, R. C.; Hofstadter, R.; Hughes, E. B.; Hunter, S. D.; Hughlock, B. W.; Kanbach, G.; Kniffen, D. A.

    1993-01-01

    The calibration of the (EGRET) prior to its launch aboard the Compton Gamma Ray Observatory, the continuing calibration after launch, and instrument-performance results based on calibrations and early postlaunch data, are described. Particular attention is given to the effective area, the annular resolution, and the energy resolution.

  5. SAS-2 galactic gamma ray results, 1

    NASA Technical Reports Server (NTRS)

    Thompson, D. J.; Fichtel, C. E.; Hartman, R. C.; Kniffen, D. A.; Bignami, G. F.; Lamb, R. C.; Oegelman, H.; Oezel, M. E.; Tuemer, T.

    1976-01-01

    Continuing analysis of the data from the SAS-2 high energy gamma-ray experiment has produced an improved picture of the sky at photon energies above 35 MeV. On a large scale, the diffuse emission from the galactic plane is the dominant feature observed by SAS-2. This galactic plane emission is most intense between galactic longitude 310 and 45 deg, corresponding to a region within 7kpc of the galactic center. Within the high-intensity region, SAS-2 observes peaks around galactic longitudes 315 deg, 330 deg, 345 deg, 0 deg, and 35 deg. These peaks appear to be correlated with such galactic features and components as molecular hydrogen, atomic hydrogen, magnetic fields, cosmic ray concentrations, and photon fields.

  6. Gamma Rays from Classical Novae

    NASA Technical Reports Server (NTRS)

    1997-01-01

    NASA at the University of Chicago, provided support for a program of theoretical research into the nature of the thermonuclear outbursts of the classical novae and their implications for gamma ray astronomy. In particular, problems which have been addressed include the role of convection in the earliest stages of nova runaway, the influence of opacity on the characteristics of novae, and the nucleosynthesis expected to accompany nova outbursts on massive Oxygen-Neon-Magnesium (ONeMg) white dwarfs. In the following report, I will identify several critical projects on which considerable progress has been achieved and provide brief summaries of the results obtained:(1) two dimensional simulation of nova runaway; (2) nucleosynthesis of nova modeling; and (3) a quasi-analytic study of nucleosynthesis in ONeMg novae.

  7. Gamma-Ray Interactions for Reachback Analysts

    SciTech Connect

    Karpius, Peter Joseph; Myers, Steven Charles

    2016-08-02

    This presentation is a part of the DHS LSS spectroscopy training course and presents an overview of the following concepts: identification and measurement of gamma rays; use of gamma counts and energies in research. Understanding the basic physics of how gamma rays interact with matter can clarify how certain features in a spectrum were produced.

  8. Gamma ray astronomy from satellites and balloons

    NASA Technical Reports Server (NTRS)

    Schoenfelder, V.

    1986-01-01

    A survey is given of gamma ray astronomy topics presented at the Cosmic Ray Conference. The major conclusions at the Cosmic Ray Conference in the field of gamma ray astronomy are given. (1) MeV-emission of gamma-ray bursts is a common feature. Variations in duration and energy spectra from burst to burst may explain the discrepancy between the measured log N - log S dependence and the observed isotropy of bursts. (2) The gamma-ray line at 1.809 MeV from Al(26) is the first detected line from a radioactive nucleosynthesis product. In order to understand its origin it will be necessary to measure its longitude distribution in the Milky Way. (3) The indications of a gamma-ray excess found from the direction of Loop I is consistent with the picture that the bulk of cosmic rays below 100 GeV is produced in galactic supernova remnants. (4) The interpretation of the large scale distribution of gamma rays in the Milky Way is controversial. At present an extragalactic origin of the cosmic ray nuclei in the GeV-range cannot be excluded from the gamma ray data. (5) The detection of MeV-emission from Cen A is a promising step towards the interesting field of extragalactic gamma ray astronomy.

  9. Scanning Gamma Ray Densitometer System for Detonations.

    DTIC Science & Technology

    in loaded detonators and delays. The 317 KEV gamma rays from an Ir192 source were collimated into a beam of 0.002 by 0.100 inch. A scanning system...minus 3%. With Ir192 , density measurements on NOL-130 were reproduced to plus or minus 5%, and on RDX to plus or minus 16%. Based on gamma ray

  10. The History of Gamma-Ray Astronomy

    NASA Astrophysics Data System (ADS)

    Schönfelder, V.

    An overview of the history of gamma-ray astronomy is given starting with predictions in the 1950's and first detections in the 1960's. Tremendous efforts have been made since then, with exciting discoveries, which finally culminated in the ``Golden Age'' of gamma-ray astronomy which we are presently experiencing.

  11. The history of gamma-ray astronomy

    NASA Astrophysics Data System (ADS)

    Schönfelder, V.

    2002-07-01

    An overview of the history of gamma-ray astronomy is given starting with predictions in the 1950s and first detections in the 1960s. Tremendous efforts have been made since then, with exciting discoveries, which finally culminated in the ``Golden Age'' of gamma-ray astronomy which we are presently experiencing.

  12. Gamma-ray spectral analysis algorithm library

    SciTech Connect

    Egger, A. E.

    2013-05-06

    The routines of the Gauss Algorithms library are used to implement special purpose products that need to analyze gamma-ray spectra from Ge semiconductor detectors as a part of their function. These routines provide the ability to calibrate energy, calibrate peakwidth, search for peaks, search for regions, and fit the spectral data in a given region to locate gamma rays.

  13. ASTRONOMY: Neighborhood Gamma Ray Burst Boosts Theory.

    PubMed

    Schilling, G

    2000-07-07

    Titanic explosions that emit powerful flashes of energetic gamma rays are one of astronomy's hottest mysteries. Now an analysis of the nearest gamma ray burst yet detected has added weight to the popular theory that they are expelled during the death throes of supermassive stars.

  14. Very high-energy gamma rays from gamma-ray bursts.

    PubMed

    Chadwick, Paula M

    2007-05-15

    Very high-energy (VHE) gamma-ray astronomy has undergone a transformation in the last few years, with telescopes of unprecedented sensitivity having greatly expanded the source catalogue. Such progress makes the detection of a gamma-ray burst at the highest energies much more likely than previously. This paper describes the facilities currently operating and their chances for detecting gamma-ray bursts, and reviews predictions for VHE gamma-ray emission from gamma-ray bursts. Results to date are summarized.

  15. Origin of the gamma ray bursts

    NASA Astrophysics Data System (ADS)

    Vahia, M. N.; Rao, A. R.

    1988-12-01

    The authors establish a similarity between the gamma ray burst characteristics and solar hard X-ray flares. They show that all the temporal and spectral features observed in gamma ray bursts are also seen in solar hard X-ray flares. The only distinction is in the energy contents of the two. The authors suggest that the gamma-ray bursts originate from sources which have Sun like activity. Large scale Sun like activity has been observed in flare stars, RS CVn binaries and cataclysmic variables which are grouped together as the magnetically active stellar systems. The energetics of such systems is discussed and it is shown that these systems have enough energy to produce gamma-ray bursts. The authors then attempt positional identification between gamma-ray burst error boxes and the magnetically active stellar systems and find an association of 34 objects.

  16. Unveiling the secrets of gamma ray bursts

    NASA Astrophysics Data System (ADS)

    Gomboc, Andreja

    2012-07-01

    Gamma Ray Bursts are unpredictable and brief flashes of gamma rays that occur about once a day in random locations in the sky. Since gamma rays do not penetrate the Earth's atmosphere, they are detected by satellites, which automatically trigger ground-based telescopes for follow-up observations at longer wavelengths. In this introduction to Gamma Ray Bursts we review how building a multi-wavelength picture of these events has revealed that they are the most energetic explosions since the Big Bang and are connected with stellar deaths in other galaxies. However, in spite of exceptional observational and theoretical progress in the last 15 years, recent observations raise many questions which challenge our understanding of these elusive phenomena. Gamma Ray Bursts therefore remain one of the hottest topics in modern astrophysics.

  17. Atmospheric gamma-ray and neutron flashes

    SciTech Connect

    Babich, L. P. Kudryavtsev, A. Yu. Kudryavtseva, M. L. Kutsyk, I. M.

    2008-01-15

    Gamma-ray pulses are calculated from 2D numerical simulations of an upward atmospheric discharge in a self-consistent electric field using the multigroup approach to the kinetics of relativistic runaway electrons (REs). Computed {gamma}-ray numbers and spectra are consistent with those of terrestrial {gamma}-ray flashes (TGFs) observed aboard spacecrafts. The RE flux is concentrated mainly within the domain of the Blue Jet fluorescence. This confirms that exactly the domain adjacent to a thundercloud is the source of the observed {gamma}-ray flashes. The yield of photonuclear neutrons is calculated. One {gamma}-ray pulse generates {approx}10{sup 14}-10{sup 15} neutrons. The possibility of the direct deposition of REs to the detector readings and the origin of the lightning-advanced TGFs are discussed.

  18. Future Missions for Gamma-Ray Astronomy

    NASA Technical Reports Server (NTRS)

    Meegan, Charles; Rose, M. Franklin (Technical Monitor)

    2000-01-01

    Gamma-ray astronomy has made great advances in recent years, due largely to the recently completed 9-year mission of the Compton Gamma Ray Observatory. In this talk I will give an overview of what advances we may expect in the near future, with particular emphasis on earth-orbiting missions scheduled for flight within the next 5 years. Two missions, the High Energy Transient Explorer and Swift, will provide important new information on the sources of gamma-ray bursts. The Gamma-Ray Large Area Space Telescope will investigate high energy emission from a wide variety of sources, including active galaxies and gamma-ray pulsars. The contributions of ground-based and multiwavelength observations will also be addressed.

  19. Instrumentation for gamma-ray astronomy

    NASA Technical Reports Server (NTRS)

    Bertsch, David L.; Fichtel, Carl E.; Trombka, Jacob I.

    1988-01-01

    The current status of gamma-ray-telescope technology for ground, airborne, and space observations is surveyed and illustrated with drawings, diagrams, and graphs and tables of typical data. For the low- and medium-energy ranges, consideration is given to detectors and detector cooling systems, background-rejection methods, radiation damage, large-area detectors, gamma-ray imaging, data analysis, and the Compton-interaction region. Also discussed are the gamma-ray interaction process at high energies; multilevel automated spark-chamber gamma-ray telescopes; the Soviet Gamma-1 telescope; the EGRET instrument for the NASA Gamma-Ray Observatory; and Cerenkov, air-shower, and particle-detector instruments for the TeV and PeV ranges. Significant improvements in resolution and sensitivity are predicted for the near future.

  20. The Contribution of Tissue Level Organization to Genomic Stability Following Low Dose/Low Dose Rate Gamma and Proton Irradiation

    SciTech Connect

    Cheryl G. Burrell, Ph.D.

    2012-05-14

    The formation of functional tissue units is necessary in maintaining homeostasis within living systems, with individual cells contributing to these functional units through their three-dimensional organization with integrin and adhesion proteins to form a complex extra-cellular matrix (ECM). This is of particular importance in those tissues susceptible to radiation-induced tumor formation, such as epithelial glands. The assembly of epithelial cells of the thyroid is critical to their normal receipt of, and response to, incoming signals. Traditional tissue culture and live animals present significant challenges to radiation exposure and continuous sampling, however, the production of bioreactor-engineered tissues aims to bridge this gap by improve capabilities in continuous sampling from the same functional tissue, thereby increasing the ability to extrapolate changes induced by radiation to animals and humans in vivo. Our study proposes that the level of tissue organization will affect the induction and persistence of low dose radiation-induced genomic instability. Rat thyroid cells, grown in vitro as 3D tissue analogs in bioreactors and as 2D flask grown cultures were exposed to acute low dose (1, 5, 10 and 200 cGy) gamma rays. To assess immediate (6 hours) and delayed (up to 30 days) responses post-irradiation, various biological endpoints were studied including cytogenetic analyses, apoptosis analysis and cell viability/cytotoxicity analyses. Data assessing caspase 3/7 activity levels show that, this activity varies with time post radiation and that, overall, 3D cultures display more genomic instability (as shown by the lower levels of apoptosis over time) when compared to the 2D cultures. Variation in cell viability levels were only observed at the intermediate and late time points post radiation. Extensive analysis of chromosomal aberrations will give further insight on the whether the level of tissue organization influences genomic instability patterns after

  1. Simultaneous observation of the gamma-ray binary LS I+61 303 with GLAST and Suzaku

    SciTech Connect

    Tanaka, Takuya; Fukazawa, Yasushi; Mizuno, Tsunefumi; Katagiri, Hideaki; Takahashi, Hiromitsu; Kawabata, Koji S.; Nagae, Osamu; Ohsugi, Takashi

    2007-07-12

    The gamma-ray binary LS I+61 303 is a bright gamma-ray source, and thus an attracting object for GLAST. We proposed to observe this object with the X-ray satellite Suzaku (AO-2), simultaneously with GLAST, radio wave, and optical spectro-polarimetry, in order to probe the geometrical state of the binary system emitting the gamma-ray radiation, as a function of the binary orbital phase for the first time. This is essential to understand the mechanism of jet production and gamma-ray emission. The idea is not only to measure the multi-band overall continuum shape, but also to make use of continuous monitoring capability of GLAST, wide X-ray band of Suzaku, and good accessibility of the Kanata optical/NIR telescope (Hiroshima University) with the sensitive optical spectro-polarimetry. Further collaboration with TeV gamma-ray telescopes is also hoped to constrain the jet constitution.

  2. Modeling gamma-ray bursts

    NASA Astrophysics Data System (ADS)

    Maxham, Amanda

    Discovered serendipitously in the late 1960s, gamma-ray bursts (GRBs) are huge explosions of energy that happen at cosmological distances. They provide a grand physical playground to those who study them, from relativistic effects such as beaming, jets, shocks and blastwaves to radiation mechanisms such as synchrotron radiation to galatic and stellar populations and history. Through the Swift and Fermi space telescopes dedicated to observing GRBs over a wide range of energies (from keV to GeV), combined with accurate pinpointing that allows ground based follow-up observations in the optical, infrared and radio, a rich tapestry of GRB observations has emerged. The general picture is of a mysterious central engine (CE) probably composed of a black hole or neutron star that ejects relativistic shells of matter into intense magnetic fields. These shells collide and combine, releasing energy in "internal shocks" accounting for the prompt emission and flaring we see and the "external shock" or plowing of the first blastwave into the ambient surrounding medium has well-explained the afterglow radiation. We have developed a shell model code to address the question of how X-ray flares are produced within the framework of the internal shock model. The shell model creates randomized GRB explosions from a central engine with multiple shells and follows those shells as they collide, merge and spread, producing prompt emission and X-ray flares. We have also included a blastwave model, which can constrain X-ray flares and explain the origin of high energy (GeV) emission seen by the Fermi telescope. Evidence suggests that gamma-ray prompt emission and X-ray flares share a common origin and that at least some flares can only be explained by long-lasting central engine activity. We pay special attention to the time history of central engine activity, internal shocks, and observed flares. We calculate the gamma-ray (Swift/BAT band) and X-ray (Swift/XRT band) lightcurves for arbitrary

  3. Analysis of data from the energetic gamma-ray experiment on the gamma ray observatory

    NASA Technical Reports Server (NTRS)

    Kniffen, Donald A.

    1993-01-01

    The work under the Grant has involved continued participation with the Compton Gamma Ray Observatory Energetic Gamma-Ray Experiment Telescope (EGRET) Team in the analysis of data obtained during instrument operations and the preparation of scientific papers and proposals for future observations. The EGRET team was also successful on many proposals for the Phase 3 portion of the mission, including long high galactic latitude studies of the diffuse extragalactic radiation. These studies will be used in a effort to establish whether this radiation is truly diffuse or the sum of radiation from unresolved discrete sources such as radio-loud quasars. The effort involved working remotely by internet connection on the Goddard Space Flight Center Computers where the EGRET data are archived. Students have monitored instrument performance and analyzed data remotely and will continue to do so. The PI has completed the detailed analysis of five viewing periods to search for point sources and this work has been used in developing the first EGRET catalog of sources, soon to be released.

  4. Analysis of data from the energetic gamma-ray experiment of the Gamma Ray Observatory

    NASA Technical Reports Server (NTRS)

    Kniffen, Donald A.

    1995-01-01

    The work under the Grant has involved continued participation with the Compton Gamma Ray Observatory Energetic Gamma-Ray Experiment Telescope (EGRET) Team in the analysis of data obtained during instrument operations and the preparation of scientific papers and proposals for future observations. The EGRET team continues to submit IAU Astronomical telegrams and present many papers at scientific meetings. The EGRET Team was also successful on many proposals for the Cycle 4 portion of the mission, including long high galactic latitude studies of the diffuse extragalactic radiation in both the Northern and Southern Galactic Sky. These studies will be used in an effort to establish whether this radiation is truly diffuse or the sum of radiation from unresolved discrete sources such as radio-loud quasars. Data analysis is complete for papers on behalf of the EGRET Team by the author on general sources in the anticenter region of the galaxy, with galactic latitudes from 125 to 220 deg. A paper on this subject is in preparation for publication in the Astrophysical Journal. Another is being prepared on EGRET observations of the COS-B source 2CG135. Work is in progress for a third on the contribution of unresolved pulsars to the galactic diffuse radiations; two other papers are in analysis phase. A number of papers have been published in the last reporting period, and several others are in press currently. A summary of the publications is described.

  5. Gamma-Ray Astronomy with the Hawc Observatory

    NASA Astrophysics Data System (ADS)

    Lauer, Robert J.

    2014-03-01

    The High Altitude Water Cherenkov (HAWC) Observatory is a wide field-of-view gamma-ray detector, sensitive to primary energies between 50 GeV and 100 TeV. The array is being built at an altitude of 4,100 m on the Sierra Negra volcano in Puebla, Mexico. With a duty cycle close to 100% and a daily coverage of 8 sr of the sky above it, HAWC is ideally suited to detect bright transient events at TeV energies such as gamma-ray bursts or flares from active galactic nuclei. The array will provide an unbiased survey of gamma-ray sources at energies above 100 GeV and probe the origins of astrophysical photon emission at the highest energies. The modular design of HAWC made it possible to start data taking in September 2012 with a partial array. Operation continues while the number of water Cherenkov detectors is growing, which allowed a smooth transition to full scientific operation with 111 detectors in August 2013. The completion of the full array with 300 detectors is planned for the summer of 2014. In these proceedings, we will give an overview of the status and performance of the HAWC observatory and discuss observation strategies for various gamma-ray phenomena.

  6. A COMPARISON OF GADRAS SIMULATED AND MEASURED GAMMA RAY SPECTRA

    SciTech Connect

    Jeffcoat, R.; Salaymeh, S.

    2010-06-28

    Gamma-ray radiation detection systems are continuously being developed and improved for detecting the presence of radioactive material and for identifying isotopes present. Gamma-ray spectra, from many different isotopes and in different types and thicknesses of attenuation material and matrixes, are needed to evaluate the performance of these devices. Recently, a test and evaluation exercise was performed by the Savannah River National Laboratory that required a large number of gamma-ray spectra. Simulated spectra were used for a major portion of the testing in order to provide a pool of data large enough for the results to be statistically significant. The test data set was comprised of two types of data, measured and simulated. The measured data were acquired with a hand-held Radioisotope Identification Device (RIID) and simulated spectra were created using Gamma Detector Response and Analysis Software (GADRAS, Mitchell and Mattingly, Sandia National Laboratory). GADRAS uses a one-dimensional discrete ordinate calculation to simulate gamma-ray spectra. The measured and simulated spectra have been analyzed and compared. This paper will discuss the results of the comparison and offer explanations for spectral differences.

  7. Observing Modes of the Fermi Gamma-ray Space Telescope

    NASA Astrophysics Data System (ADS)

    Ferrara, Elizabeth C.; McEnery, J.; Fermi Mission Team

    2009-01-01

    The Fermi Gamma-ray Space Telescope (formerly GLAST) is a low-earth orbiting mission supporting two science instruments, the Gamma-Ray Burst Monitor (GBM), a near-all-sky detector in the 8 keV to 30 MeV range, and the Large Area Telescope (LAT), a wide field pair-conversion detector sensitive in the 20 MeV to 300 GeV range. The dominant observing mode of Fermi is a sky survey in which the observatory will be rocked about the orbital plane to provide almost uniform coverage of the entire sky every three hours. This results in continuous monitoring of all sources on timescales greater than 3 hours, guaranteeing gamma-ray data for a wide range of studies. Fermi is also capable of performing pointed observations which may be useful for studies of very bright, rapidly variable sources that benefit from more densely sampled observations, such as gamma-ray bursts and their afterglows. However, pointed observations will have a detrimental effect on coverage of the rest of the sky, which may hurt multiwavelength campaigns and uniformity of time monitoring studies. We describe these observational modes of Fermi and how they are affected by multiple operational constraints such as data generation rate and downlink, sun avoidance, and Earth avoidance. We show how the pointing profile of the observatory affects the LAT sky exposure, and discuss the relative merits of different observing strategies for various science objectives.

  8. Software tool for xenon gamma-ray spectrometer control

    NASA Astrophysics Data System (ADS)

    Chernysheva, I. V.; Novikov, A. S.; Shustov, A. E.; Dmitrenko, V. V.; Pyae Nyein, Sone; Petrenko, D.; Ulin, S. E.; Uteshev, Z. M.; Vlasik, K. F.

    2016-02-01

    Software tool "Acquisition and processing of gamma-ray spectra" for xenon gamma-ray spectrometers control was developed. It supports the multi-windows interface. Software tool has the possibilities for acquisition of gamma-ray spectra from xenon gamma-ray detector via USB or RS-485 interfaces, directly or via TCP-IP protocol, energy calibration of gamma-ray spectra, saving gamma-ray spectra on a disk.

  9. Multi-level effects of low dose rate ionizing radiation on southern toad, Anaxyrus [Bufo] terrestris

    SciTech Connect

    Stark, Karolina; Scott, David E.; Tsyusko, Olga; Coughlin, Daniel P.; Hinton, Thomas G.; Amendola, Roberto

    2015-04-30

    Despite their potential vulnerability to contaminants from exposure at multiple life stages, amphibians are one of the least studied groups of vertebrates in ecotoxicology, and research on radiation effects in amphibians is scarce. We used multiple endpoints to assess the radiosensitivity of the southern toad (Anaxyrus [Bufo] terrestris) during its pre-terrestrial stages of development –embryonic, larval, and metamorphic. Toads were exposed, from several hours after oviposition through metamorphosis (up to 77 days later), to four low dose rates of ¹³⁷Cs at 0.13, 2.4, 21, and 222 mGy d⁻¹, resulting in total doses up to 15.8 Gy. Radiation treatments did not affect hatching success of embryos, larval survival, or the length of the larval period. The individual family variation in hatching success of embryos was larger than the radiation response. In contrast, newly metamorphosed individuals from the higher dose-rate treatments had higher mass and mass/length body indices, a measure which may relate to higher post-metamorphic survival. The increased mass and index at higher dose rates may indicate that the chronic, low dose rate radiation exposures triggered secondary responses. Additionally, the increases in growth were linked to a decrease in DNA damage (as measured by the Comet Assay) in red blood cells at a dose rate of 21mGy d⁻¹ and a total dose of 1.1 Gy. In conclusion, the complex effects of low dose rates of ionizing radiation may trigger growth and cellular repair mechanisms in amphibian larvae.

  10. SU-E-T-145: Beam Characteristics of Flattening Filter Free Beams Including Low Dose Rate Setting

    SciTech Connect

    Uehara, K; Ogata, T; Nakayama, M; Shinji, T; Nishimura, H; Masutani, T; Ishihara, T; Ejima, Y; Sasaki, R

    2015-06-15

    Purpose: In commissioning of volumetric modulated arc therapy (VMAT), it is necessary to evaluate the beam characteristics of various dose rate settings with potential to use. The aim of this study is to evaluate the beam characteristics of flattened and flattening filter free (FFF) including low dose rate setting. Methods: We used a Varian TrueBeam with Millennium 120 MLC. Both 6 and 10 MV beams with or without flattening filter were used for this study. To evaluate low-dose rate FFF beams, specially-designed leaf sequence files control out-of-field MLC leaf pair at constant dose rate ranging from 80 to 400 MU/min. For dose rate from 80 MU/min to the maximum usable value of all energies, beam output were measured using ionization chamber (CC04, IBA). The ionization chamber was inserted into water equivalent phantom (RT3000-New, R-tech), and the phantom was set with SAD of 100cm. The beam profiles were performed using the 2D diode array (Profiler2, Sun Nuclear). The SSD was set to 90cm and a combined 30cmx30cmx9cm phantom which consisted of solid water slabs was put on the device. All measurement were made using 100MU irradiation for 10cmx10cm jaw-defined field size with a gantry angle of 0°. Results: In all energies, the dose rate dependences with beam output and variation coefficient were within 0.2% and 0.07%, respectively. The flatness and symmetry exhibited small variations (flatness ≤0.1 point and symmetry≤0.3 point at absolute difference). Conclusion: We had studied the characteristics of flattened and FFF beam over the 80 MU/min. Our results indicated that the beam output and profiles of FFF of TrueBeam linac were highly stable at low dose rate setting.

  11. Low-dose-rate or high-dose-rate brachytherapy in treatment of prostate cancer – between options

    PubMed Central

    2013-01-01

    Purpose Permanent low-dose-rate (LDR-BT) and temporary high-dose-rate (HDR-BT) brachytherapy are competitive techniques for clinically localized prostate radiotherapy. Although a randomized trial will likely never to be conducted comparing these two forms of brachytherapy, a comparative analysis proves useful in understanding some of their intrinsic differences, several of which could be exploited to improve outcomes. The aim of this paper is to look for possible similarities and differences between both brachytherapy modalities. Indications and contraindications for monotherapy and for brachytherapy as a boost to external beam radiation therapy (EBRT) are presented. It is suggested that each of these techniques has attributes that advocates for one or the other. First, they represent the extreme ends of the spectrum with respect to dose rate and fractionation, and therefore have inherently different radiobiological properties. Low-dose-rate brachytherapy has the great advantage of being practically a one-time procedure, and enjoys a long-term follow-up database supporting its excellent outcomes and low morbidity. Low-dose-rate brachytherapy has been a gold standard for prostate brachytherapy in low risk patients since many years. On the other hand, HDR is a fairly invasive procedure requiring several sessions associated with a brief hospital stay. Although lacking in significant long-term data, it possesses the technical advantage of control over its postimplant dosimetry (by modulating the source dwell time and position), which is absent in LDR brachytherapy. This important difference in dosimetric control allows HDR doses to be escalated safely, a flexibility that does not exist for LDR brachytherapy. Conclusions Radiobiological models support the current clinical evidence for equivalent outcomes in localized prostate cancer with either LDR or HDR brachytherapy, using current dose regimens. At present, all available clinical data regarding these two techniques

  12. Caffeine induces a second wave of apoptosis after low dose-rate gamma radiation of HL-60 cells.

    PubMed

    Vávrová, Jirina; Mareková-Rezácová, Martina; Vokurková, Doris; Szkanderová, Sylva; Psutka, Jan

    2003-10-01

    Most cell lines that lack functional p53 protein are arrested in the G(2) phase of the cell cycle due to DNA damage. It was previously found that the human promyelocyte leukemia cells HL-60 (TP53 negative) that had been exposed to ionizing radiation at doses up to 10 Gy were arrested in the G(2) phase for a period of 24 h. The radioresistance of HL-60 cells that were exposed to low dose-rate gamma irradiation of 3.9 mGy/min, which resulted in a pronounced accumulation of the cells in the G(2) phase during the exposure period, increased compared with the radioresistance of cells that were exposed to a high dose-rate gamma irradiation of 0.6 Gy/min. The D(0) value (i.e. the radiation dose leading to 37% cell survival) for low dose-rate radiation was 3.7 Gy and for high dose-rate radiation 2.2 Gy. In this study, prevention of G(2) phase arrest by caffeine (2 mM) and irradiation of cells with low dose-rate irradiation in all phases of the cell cycle proved to cause radiosensitization (D(0)=2.2 Gy). The irradiation in the presence of caffeine resulted in a second wave of apoptosis on days 5-7 post-irradiation. Caffeine-induced apoptosis occurring later than day 7 post-irradiation is postulated to be a result of unscheduled DNA replication and cell cycle progress.

  13. Gamma-Ray Burst Physics with GLAST

    SciTech Connect

    Omodei, N.; /INFN, Pisa

    2006-10-06

    The Gamma-ray Large Area Space Telescope (GLAST) is an international space mission that will study the cosmos in the energy range 10 keV-300 GeV, the upper end of which is one of the last poorly observed region of the celestial electromagnetic spectrum. The ancestor of the GLAST/LAT was the Energetic Gamma Ray Experiment Telescope (EGRET) detector, which flew onboard the Compton Gamma Ray Observatory (CGRO). The amount of information and the step forward that the high energy astrophysics made thanks to its 9 years of observations are impressive. Nevertheless, EGRET uncovered the tip of the iceberg, raising many questions, and it is in the light of EGRET's results that the great potential of the next generation gamma-ray telescope can be appreciated. GLAST will have an imaging gamma-ray telescope, the Large Area Telescope (LAT) vastly more capable than instruments own previously, as well as a secondary instrument, the GLAST Bursts Monitor, or GBM, to augment the study of gamma-ray bursts. Gamma-Ray Bursts (GRBs) science is one of the most exciting challenges for the GLAST mission, exploring the high energy emission of one of the most intense phenomena in the sky, shading light on various problems: from the acceleration of particles to the emission processes, to more exotic physics like Quantum Gravity effect. In this paper we report the work done so far in the simulation development as well as the study of the LAT sensitivity to GRB.

  14. Python in gamma-ray astronomy

    NASA Astrophysics Data System (ADS)

    Deil, Christoph Deil

    2016-03-01

    Gamma-ray astronomy is a relatively new window on the cosmos. The first source detected from the ground was the Crab nebula, seen by the Whipple telescope in Arizona in 1989. Today, about 150 sources have been detected at TeV energies using gamma-ray telescopes from the ground such as H.E.S.S. in Namibia or VERITAS in Arizona, and about 3000 sources at GeV energies using the Fermi Gamma-ray Space Telescope. Soon construction will start for the Cherenkov Telescope Array (CTA), which will be the first ground-based gamma-ray telescope array operated as an open observatory, with a site in the southern and a second site in the northern hemisphere. In this presentation I will give a very brief introduction to gamma-ray astronomy and data analysis, as well as a short overview of the software used for the various missions. The main focus will be on recent attempts to build open-source gamma-ray software on the scientific Python stack and Astropy: ctapipe as a CTA Python pipeline prototype, Fermipy and the Fermi Science Tools for Fermi-LAT analysis, Gammapy as a community-developed gamma-ray Python package and naima as a non-thermal spectral modeling and fitting package.

  15. Gamma-Ray Emission from Microquasars

    NASA Astrophysics Data System (ADS)

    Kaufman Bernado, M. M.

    2005-04-01

    Microquasars, X-ray binary systems that generate relativistic jets, were discovered in our Galaxy in the last decade of the XXth century. Their name indicates that they are manifestations of the same physics as quasars but on a completely different scale. Parallel to this discovery, the EGRET instrument on board of the Compton Gamma Ray Observatory detected 271 point like gamma-ray sources 170 of which were not clearly identified with known objects. This marked the beginning of gamma-ray source population studies in the Galaxy. We present in this thesis models for gamma-ray production in microquasars with the aim to propose them as possible parent populations for different groups of EGRET unidentified sources. These models are developed for a variety of scenarios taking into account several possible combinations, i.e. black holes or neutron stars as the compact object, low mass or high mass stellar companions, as well as leptonic or hadronic gamma-ray production processes. We also show that the presented models for gamma-rays emitting microquasars can be used to explain observations from well known sources that are detected in energy ranges other than EGRET's. Finally, we include an alternative gamma-ray producing situation that does not involve microquasars but a specific unidentified EGRET source possibly linked to a magnetized accreting pulsar.

  16. Observations of Gamma-Ray Bursts

    NASA Technical Reports Server (NTRS)

    Fishman, G. J.

    1995-01-01

    Some basic observed properties of gamma-ray bursts are reviewed. Although some properties were known 25 years ago, new and more detailed observations have been made by the Compton Observatory in the past three years. The new observation with the greatest impact has been the observed isotropic distribution of bursts along with a deficiency of weak bursts which would be expected from a homogeneous burst distribution. This is not compatible with any known Galactic population of objects. Gamma-ray bursts show an enormous variety of burst morphologies and a wide spread in burst durations. The spectra of gamma-ray bursts are characterized by rapid variations and peak power which is almost entirely in the gamma-ray energy range. Delayed gamma-ray burst photons extending to GeV energies have been detected for the first time. A time dilation effect has also been reported to be observed in gamma-ray, bursts. The observation of a gamma-ray burst counterpart in another wavelength region has yet to be made.

  17. Gamma-ray Astronomy and GLAST

    NASA Technical Reports Server (NTRS)

    McEnery, Julie

    2007-01-01

    The high energy gamma-ray (30 MeV to 100 GeV) sky has been relatively poorly studied. Most of our current knowledge comes from observations made by the Energetic Gamma Ray Experiment Telescope (EGRET) detector on the Compton Gamma Ray Observatory (CGRO), which revealed that the GeV gamma-ray sky is rich and vibrant. Studies of astrophysical objects at GeV energies are interesting for several reasons: The high energy gamma-rays are often produced by a different physical process than the better studied X-ray and optical emission, thus providing a unique information for understanding these sources. Production of such high-energy photons requires that charged particles are accelerated to equally high energies, or much greater. Thus gamma-ray astronomy is the study of extreme environments, with natural and fundamental connections to cosmic-ray and neutrino astrophysics. The launch of GLAST in 2008 will herald a watershed in our understanding of the high energy gamma-ray sky, providing dramatic improvements in sensitivity, angular resolution and energy range. GLAST will open a new avenue to study our Universe as well as to answer scientific questions EGRET observations have raised. In this talk, I will describe the GLAST instruments and capabilities and highlight some of the science we expect to address.

  18. Gamma-ray Astronomy and GLAST

    NASA Technical Reports Server (NTRS)

    McEnery, Julie

    2007-01-01

    The high energy gamma-ray (30 MeV to 100 GeV) sky has been relatively poorly studied. Most of our current knowledge comes from observations made by the Energetic Gamma Ray Experiment Telescope (EGRET) detector on the Compton Gamma Ray Observatory (CGRO), which revealed that the GeV gamma-ray sky is rich and vibrant. Studies of astrophysical objects at GeV energies are interesting for several reasons: The high energy gamma-rays are often produced by a different physical process than the better studied X-ray and optical emission, thus providing a unique information for understanding these sources. Production of such high-energy photons requires that charged particles are accelerated to equally high energies, or much greater. Thus gamma-ray astronomy is the study of extreme environments, with natural and fundamental connections to cosmic-ray and neutrino astrophysics. The launch of GLAST in 2008 will herald a watershed in our understanding of the high energy gamma-ray sky, providing dramatic improvements in sensitivity, angular resolution and energy range. GLAST will open a new avenue to study our Universe as well as to answer scientific questions EGRET observations have raised. In this talk, I will describe the GLAST instruments and capabilities and highlight some of the science we expect to address.

  19. Repair of neoplastic transformation damage following protracted exposures to /sup 60/Co. gamma. -rays

    SciTech Connect

    Han, A.; Hill, C.K.; Elkind, M.M.

    1983-01-01

    The incidences of neoplastic transformation induced by /sup 60/Co ..gamma..-rays in exponentially growing mouse embryo 10T1/2 cells were measured following acute and protracted exposures. Delivery of /sup 60/Co ..gamma..-rays at a low dose rate (0.1, 0.5, 2.5 rad/min) compared with a high dose rate (100 rad/min) results in appreciable, dose rate dependent reductions in cell killing and, independent of the effect on cell survival, reduces significantly the incidence of neoplastic transformation. Exposure of exponentially growing 10T1/2 cells to a dose of ..gamma..-rays in five equal daily fractions also significantly reduces transformation frequency, compared with delivery in a single dose, throughout the dose range examined (25 to 300 rads). The initial parts of the induction curves are fitted quite well by a linear dose dependence. The slopes of the regression lines for multifractionation delivery or irradiation at 0.1 rad/min, are one-third and one-half, respectively, of those for single exposures at a high dose rate. Increasing the interfraction interval up to 48 hours, or reduction of the dose per fraction further reduce incidence of neoplastic transformation. We conclude that protracted exposures of low LET radiation result in a net error-free repair of subtransformation damage.

  20. Gamma-ray burst cosmology

    NASA Astrophysics Data System (ADS)

    Wang, F. Y.; Dai, Z. G.; Liang, E. W.

    2015-08-01

    Gamma-ray bursts (GRBs) are the most luminous electromagnetic explosions in the Universe, which emit up to 8.8 × 1054 erg isotropic equivalent energy in the hard X-ray band. The high luminosity makes them detectable out to the largest distances yet explored in the Universe. GRBs, as bright beacons in the deep Universe, would be the ideal tool to probe the properties of high-redshift universe: including the cosmic expansion and dark energy, star formation rate, the reionization epoch and the metal enrichment history of the Universe. In this article, we review the luminosity correlations of GRBs, and implications for constraining the cosmological parameters and dark energy. Observations show that the progenitors of long GRBs are massive stars. So it is expected that long GRBs are tracers of star formation rate. We also review the high-redshift star formation rate derived from GRBs, and implications for the cosmic reionization history. The afterglows of GRBs generally have broken power-law spectra, so it is possible to extract intergalactic medium (IGM) absorption features. We also present the capability of high-redshift GRBs to probe the pre-galactic metal enrichment and the first stars.

  1. Gamma-Ray Burst Progenitors

    NASA Astrophysics Data System (ADS)

    Levan, Andrew; Crowther, Paul; de Grijs, Richard; Langer, Norbert; Xu, Dong; Yoon, Sung-Chul

    2016-12-01

    We review our current understanding of the progenitors of both long and short duration gamma-ray bursts (GRBs). Constraints can be derived from multiple directions, and we use three distinct strands; (i) direct observations of GRBs and their host galaxies, (ii) parameters derived from modelling, both via population synthesis and direct numerical simulation and (iii) our understanding of plausible analog progenitor systems observed in the local Universe. From these joint constraints, we describe the likely routes that can drive massive stars to the creation of long GRBs, and our best estimates of the scenarios that can create compact object binaries which will ultimately form short GRBs, as well as the associated rates of both long and short GRBs. We further discuss how different the progenitors may be in the case of black hole engine or millisecond-magnetar models for the production of GRBs, and how central engines may provide a unifying theme between many classes of extremely luminous transient, from luminous and super-luminous supernovae to long and short GRBs.

  2. NEAR Gamma Ray Spectrometer Characterization and Repair

    NASA Technical Reports Server (NTRS)

    Groves, Joel Lee; Vajda, Stefan

    1998-01-01

    This report covers the work completed in the third year of the contract. The principle activities during this period were (1) the characterization of the NEAR 2 Gamma Ray Spectrometer using a neutron generator to generate complex gamma ray spectra and a large Ge Detecter to identify all the major peaks in the spectra; (2) the evaluation and repair of the Engineering Model Unit of the Gamma Ray Spectrometer for the NEAR mission; (3) the investigation of polycapillary x-ray optics for x-ray detection; and (4) technology transfer from NASA to forensic science.

  3. Cosmic gamma-ray lines - Theory

    NASA Technical Reports Server (NTRS)

    Lingenfelter, R. E.; Ramaty, R.

    1980-01-01

    The various processes that lead to gamma-ray line emission and the possible astrophysical sources of such emission are reviewed. The processes of nuclear excitation, radiative capture, positron annihilation, and cyclotron radiation, which may produce gamma-ray line emission from such diverse sources as the interstellar medium, novas, supernovas, pulsars, accreting compact objects, the galactic nucleus and the nuclei of active galaxies are considered. The significance of the relative intensities, widths, and frequency shifts of the lines are also discussed. Particular emphasis is placed on understanding those gamma-ray lines that have already been observed from astrophysical sources.

  4. Detecting axionlike particles with gamma ray telescopes.

    PubMed

    Hooper, Dan; Serpico, Pasquale D

    2007-12-07

    We propose that axionlike particles (ALPs) with a two-photon vertex, consistent with all astrophysical and laboratory bounds, may lead to a detectable signature in the spectra of high-energy gamma-ray sources. This occurs as a result of gamma rays being converted into ALPs in the magnetic fields of efficient astrophysical accelerators according to the "Hillas criterion", such as jets of active galactic nuclei or hot spots of radio galaxies. The discovery of such an effect is possible by GLAST in the 1-100 GeV range and by ground-based gamma-ray telescopes in the TeV range.

  5. Fermi Gamma-Ray Space Telescope

    NASA Technical Reports Server (NTRS)

    McEnery, Julie E.; Michelson, Peter F.; Paclesas, William S.; Ritz, Steven

    2012-01-01

    The Fermi Gamma-ray Space Telescope, launched in June 2008, is an observatory designed to survey the high-energy gamma-ray sky. The primary instrument, the Large Area Telescope (LAT), provides observations from 20 MeV to greater than 300 GeV. A second instrument, the Gamma-ray Burst Monitor (GBM), provides observations of transients from less than 10 keV to 40 MeV. We describe the design and performance of the instruments and their subsystems, the spacecraft and the ground system.

  6. Lifetime radiation risks from low-dose rate radionuclides in beagles

    SciTech Connect

    Goldman, M.; Rosenblatt, L.S.

    1985-11-01

    One of the largest, long-term (25-yr) animal studies on the effects of low-dose internal irradiation is almost completed. Some 335 beagles were given continuous exposure to graded /sup 90/Sr (low linear energy transfer (LET)) in their diets (D-dogs) through adulthood. A second group (R-dogs) was given fractionated doses of /sup 225/Ra (high LET) as young adults. A third group of 44 was given a single injection of /sup 90/Sr as adults (S-dogs) to compare single to continuous dosages. All dogs were followed through their lifetimes. Only one of the 848 dogs is still alive. The animals were whole-body counted over their entire life span and were examined frequently for assessment of medical status. There were no acute radiation lethalities. Analyses of the large data base from these dogs have begun and preliminary indications are that /sup 90/Sr, which was tested over a 1500-fold skeletal dose rate range, does not cause significant life shortening at average accumulation skeletal doses of approx.2500 rads (25 Gy) and that a curvilinear dose response curve for life shortening was seen at higher accumulation doses. The data will be discussed in terms of modern epidemiological concepts and quantifications will be related to certain parameters of human risk from acute or chronic radiation exposures.

  7. The First Fermi Gamma-ray Burst Monitor (GBM) Terrestrial Gamma-ray Flash (TGF) Catalog

    NASA Astrophysics Data System (ADS)

    Briggs, M. S.; Connaughton, V.; Stanbro, M.; Zhang, B.; Bhat, N.; Fishman, G. J.; Roberts, O.; Fitzpatrick, G.; McBreen, S.; Grove, J. E.; Chekhtman, A.

    2014-12-01

    We present summary results from the first catalog of Terrestrial Gamma-ray Flashes (TGFs) detected with the Gamma-ray Burst Monitor (GBM) on the Fermi Space Telescope. The catalog is expected to contain about 2600 TGFs and will be released both online, to conveniently provide the community with TGF parameters, and as a publication. Since the launch of Fermi in 2008 the TGF detection sensitivity of GBM has been improved several times, both in the flight software and in ground analysis. Starting in 2010 July individual photons were downloaded for portions of the orbits, enabling an off-line search that found weaker and shorter TGFs. Since 2012 November 26 this telemetry mode has been extended to continuous coverage -- in the first year of this data mode 841 TGFs were detected. The TGF sample is reliable, with cosmic rays rejected using data both from Fermi GBM and from the Large Area Telescope on Fermi. The online catalog will include times (UTC and solar), spacecraft geographic positions, durations, count intensities and other parameters (e.g., see the Bayesian Block analysis by O. Roberts). There will be separate tables for bright TGFs detected by the flight software and Terrestrial Electron Beams (TEBs).

  8. Analysis of Data from the Energetic Gamma-ray Experiment on the Gamma Ray Observatory

    NASA Technical Reports Server (NTRS)

    Kniffen, Donald A.

    1996-01-01

    The work under the Grant has involved participation with the Compton Gamma Ray Observatory Energetic Gamma-Ray Experiment Telescope (EGRET) Team in the analysis of data obtained during instrument operations and the preparation of scientific papers and proposals for future observations. The Principal Investigator (PI) has been a co-author on a total of 90 papers published in refereed professional journals since the beginning of 1991, plus many other non-refereed publications, and contributed and invited papers at professional meetings and IAU telegrams. On seven of these papers he was the lead author. The EGRET team continues to submit IAU Astronomical telegrams and present many papers at scientific meetings. The effort by the PI has involved working remotely by internet connection on the Goddard Space Flight Center Computers where the EGRET data are archived. Students have monitored instrument performance, performed Viewing Period Analyses and analyzed data remotely. The PI has completed the detailed analysis of over 20 viewing periods to search for point sources and this work has been used in developing the first and second EGRET catalog of sources, published in Supplements to the Astrophysical Journal.

  9. Interpretations and implications of gamma ray lines from solar flares, the galactic center in gamma ray transients

    NASA Technical Reports Server (NTRS)

    Ramaty, R.; Lingenfelter, R. E.

    1980-01-01

    Observations and theories of astrophysical gamma ray line emission are reviewed and prospects for future observations by the spectroscopy experiments on the planned Gamma Ray Observatory are discussed.

  10. Chronic low-dose-rate ionising radiation affects the hippocampal phosphoproteome in the ApoE−/− Alzheimer's mouse model

    PubMed Central

    Kempf, Stefan J.; Janik, Dirk; Barjaktarovic, Zarko; Braga-Tanaka, Ignacia; Tanaka, Satoshi; Neff, Frauke; Saran, Anna; Larsen, Martin R.; Tapio, Soile

    2016-01-01

    Accruing data indicate that radiation-induced consequences resemble pathologies of neurodegenerative diseases such as Alzheimer's. The aim of this study was to elucidate the effect on hippocampus of chronic low-dose-rate radiation exposure (1 mGy/day or 20 mGy/day) given over 300 days with cumulative doses of 0.3 Gy and 6.0 Gy, respectively. ApoE deficient mutant C57Bl/6 mouse was used as an Alzheimer's model. Using mass spectrometry, a marked alteration in the phosphoproteome was found at both dose rates. The radiation-induced changes in the phosphoproteome were associated with the control of synaptic plasticity, calcium-dependent signalling and brain metabolism. An inhibition of CREB signalling was found at both dose rates whereas Rac1-Cofilin signalling was found activated only at the lower dose rate. Similarly, the reduction in the number of activated microglia in the molecular layer of hippocampus that paralleled with reduced levels of TNFα expression and lipid peroxidation was significant only at the lower dose rate. Adult neurogenesis, investigated by Ki67, GFAP and NeuN staining, and cell death (activated caspase-3) were not influenced at any dose or dose rate. This study shows that several molecular targets induced by chronic low-dose-rate radiation overlap with those of Alzheimer's pathology. It may suggest that ionising radiation functions as a contributing risk factor to this neurodegenerative disease. PMID:27708245

  11. High-energy gamma rays from the intense 1993 January 31 gamma-ray burst

    NASA Technical Reports Server (NTRS)

    Sommer, M.; Bertsch, D. L.; Dingus, B. L.; Fichtel, C. E.; Fishman, G. J.; Harding, A. K.; Hartman, R. C.; Hunter, S. D.; Hurley, K.; Kanbach, G.

    1994-01-01

    The intense gamma-ray burst of 1993 January 31 was detected by the Energetic Gamma Ray Experiment Telescope (EGRET) on the Compton Observatory. Sixteen gamma rays above 30 MeV were imaged in the telescope when only 0.04 gamma rays were expected by chance. Two of these gamma rays have energies of approximately 1 GeV, and the five bin spectrum of the 16 events is fitted by a power law of photon spectral index -2.0 +/- 0.4. The high-energy emission extends for at least 25 s. The most probable direction for this burst is determined from the directions of the 16 gamma rays observed by Egret and also by requiring the position to lie on annulus derived by the Interplanetary Network.

  12. Enhanced low dose rate sensitivity (ELDRS) of linear circuits in a space environment

    SciTech Connect

    Titus, J.L.; Emily, D.; Krieg, J.F.; Turflinger, T.; Pease, R.L.; Campbell, A.

    1999-12-01

    To investigate the ELDRS effect in a real space environment, an experiment was designed, launched, and placed in a highly elliptical orbit in November 1997. After its deployment, the electrical responses of several bipolar transistors and linear circuits have been and continue to be recorded once during every 12-hour orbit. System dosimeters are monitored to establish an average accumulated dose per orbit. With this information, the electrical parameter data are correlated with the dosimetry data to determine the total dose response of each device. This paper updates information on the ELDRS experiment through May 14, 1999. As of this date, the experiment has been in flight for a period of 18 months and has accumulated an approximate dose of 18 krd(Si). For comparison, devices, specifically linear circuits with the same date code, were irradiated using Co-60 sources, herein defined as ground-based tests. The ground-based tests are used to evaluate two hardness assurance tests, a room temperature irradiation at 10 mrd(Si)/s and an elevated temperature irradiation at 100 C and 10 rd(Si)/s and to evaluate the ELDRS response. To that end, irradiations were performed at room temperature, approximately 22 C, at fixed dose rates of 100, 1, and 0.01 rd(Si)/s and at elevated temperature, approximately 100 C, at a fixed dose rate of 10 rd(Si)/s. Currently, irradiations are being performed at room temperature at a fixed dose rate of 0.001 rd(Si)/s. Comparing the ground-based data to the flight data clearly demonstrates that enhanced parametric degradation has occurred in the flight parts. The two hardness assurance screens predicted ELDRS but the design margin for the elevated temperature test may not be adequate.

  13. Gamma-Ray Pulsar Studies With GLAST

    SciTech Connect

    Thompson, D.J.; /NASA, Goddard

    2011-11-23

    Some pulsars have their maximum observable energy output in the gamma-ray band, offering the possibility of using these high-energy photons as probes of the particle acceleration and interaction processes in pulsar magnetospheres. After an extended hiatus between satellite missions, the recently-launched AGILE mission and the upcoming Gamma-ray Large Area Space Telescope (GLAST) Large Area Telescope (LAT) will allow gamma-ray tests of the theoretical models developed based on past discoveries. With its greatly improved sensitivity, better angular resolution, and larger energy reach than older instruments, GLAST LAT should detect dozens to hundreds of new gamma-ray pulsars and measure luminosities, light curves, and phase-resolved spectra with unprecedented resolution. It will also have the potential to find radio-quiet pulsars like Geminga, using blind search techniques. Cooperation with radio and X-ray pulsar astronomers is an important aspect of the LAT team's planning for pulsar studies.

  14. Gamma rays from giant molecular clouds

    NASA Technical Reports Server (NTRS)

    Hunter, Stanley D.; Kanbach, Gottfried

    1990-01-01

    Giant Molecular Clouds (GMCs) are massive, bounded, cool, dense regions containing mostly H2, but also H I, CO, and other molecules. These clouds occupy less than 1 percent of the galactic volume, but are a substantial part of the interstellar mass. They are irradiated by the high energy cosmic rays which are possibly modulated by the matter and magnetic fields within the clouds. The product of cosmic-ray flux and matter density is traced by the emission of high energy gamma-rays. A spherical cloud model is considered and the gamma ray flux from several GMCs within 1 kpc of the sun which should be detectable by the EGRET (Energetic Gamma-Ray Experimental Telescope) instrument on GRO (Gamma Ray Observatory).

  15. Gamma-ray spectroscopy - Requirements and prospects

    NASA Technical Reports Server (NTRS)

    Matteson, James L.

    1991-01-01

    The only previous space instrument which had sufficient spectral resolution and directionality for the resolution of astrophysical sources was the Gamma-Ray Spectrometer carried by HEAO-3. A broad variety of astrophysical investigations entail gamma-ray spectroscopy of E/Delta-E resolving power of the order of 500 at 1 MeV; it is presently argued that a sensitivity to narrow gamma-ray lines of a few millionths ph/sq cm, from about 10 keV to about 10 MeV, should typify the gamma-ray spectrometers of prospective missions. This performance is achievable with technology currently under development, and could be applied to the NASA's planned Nuclear Astrophysics Explorer.

  16. Gamma-ray observatory INTEGRAL reloaded

    NASA Astrophysics Data System (ADS)

    van den Heuvel, Edward P. J.

    2017-04-01

    The scientific aims of the European Space Agency's International Gamma-Ray Astrophysics Laboratory are considerably extended because of its unique capability to identify electromagnetic counterparts to sources of gravitational waves and ultra-high-energy neutrinos.

  17. Overview Animation of Gamma-ray Burst

    NASA Image and Video Library

    Gamma-ray bursts are the most luminous explosions in the cosmos. Astronomers think most occur when the core of a massive star runs out of nuclear fuel, collapses under its own weight, and forms a b...

  18. Zapping Mars Rocks with Gamma Rays

    NASA Astrophysics Data System (ADS)

    Taylor, G. J.

    1999-12-01

    Because we do not know what deadly microorganisms might be lurking inside samples returned from Mars, the samples will either have to be sterilized before release or kept in isolation until biological studies declare them safe. One way to execute microorganisms is with radiation, such as gamma rays. Although quite effective in snuffing out bacteria and viruses, gamma rays might also affect the mineralogical, chemical, and isotopic compositions of the zapped rocks and soils. Carl Allen (Lockheed Martin Space Operations, Houston) and a team of 18 other analysts tested the effect of gamma rays on rock and mineral samples like those we expect on Mars. Except for some darkening of some minerals, high doses of gamma rays had no significant effect on the rocks, making gamma radiation a feasible option for sterilizing samples returned from Mars.

  19. The EGRET high energy gamma ray telescope

    NASA Technical Reports Server (NTRS)

    Hartman, R. C.; Bertsch, D. L.; Fichtel, C. E.; Hunter, S. D.; Kanbach, G.; Kniffen, D. A.; Kwok, P. W.; Lin, Y. C.; Mattox, J. R.; Mayer-Hasselwander, H. A.

    1992-01-01

    The Energetic Gamma Ray Experiment Telescope (EGRET) on the Compton Gamma Ray Observatory (GRO) is sensitive in the energy range from about 20 MeV to about 30,000 MeV. Electron-positron pair production by incident gamma photons is utilized as the detection mechanism. The pair production occurs in tantalum foils interleaved with the layers of a digital spark chamber system; the spark chamber records the tracks of the electron and positron, allowing the reconstruction of the arrival direction of the gamma ray. If there is no signal from the charged particle anticoincidence detector which surrounds the upper part of the detector, the spark chamber array is triggered by two hodoscopes of plastic scintillators. A time of flight requirement is included to reject events moving backward through the telescope. The energy of the gamma ray is primarily determined by absorption of the energies of the electron and positron in a 20 cm deep NaI(Tl) scintillator.

  20. Gamma-Ray "Raindrops" from Flaring Blazar

    NASA Image and Video Library

    2017-09-28

    This visualization shows gamma rays detected during 3C 279's big flare by the LAT instrument on NASA's Fermi satellite. Gamma rays are represented as expanding circles reminiscent of raindrops on water. The flare is an abrupt shower of "rain" that trails off toward the end of the movie. Both the maximum size of the circle and its color represent the energy of the gamma ray, with white lowest and magenta highest. In a second version of the visualization, a background map shows how the LAT detects 3C 279 and other sources by accumulating high-energy photons over time (brighter squares reflect higher numbers of gamma rays). The movie starts on June 14 and ends June 17. The area shown is a region of the sky five degrees on a side and centered on the position of 3C 279. Read more: go.nasa.gov/1TqximF Credits: NASA/DOE/Fermi LAT Collaboration

  1. POPULATION SYNTHESIS AND GAMMA RAY BURST PROGENITORS

    SciTech Connect

    C. L. FREYER

    2000-12-11

    Population synthesis studies of binaries are always limited by a myriad of uncertainties from the poorly understood effects of binary mass transfer and common envelope evolution to the many uncertainties that still remain in stellar evolution. But the importance of these uncertainties depends both upon the objects being studied and the questions asked about these objects. Here I review the most critical uncertainties in the population synthesis of gamma-ray burst progenitors. With a better understanding of these uncertainties, binary population synthesis can become a powerful tool in understanding, and constraining, gamma-ray burst models. In turn, as gamma-ray bursts become more important as cosmological probes, binary population synthesis of gamma-ray burst progenitors becomes an important tool in cosmology.

  2. The gamma-ray telescope Gamma-1

    NASA Technical Reports Server (NTRS)

    Akimov, V. V.; Nesterov, V. E.; Kalinkin, L. F.; Balibanov, V. M.; Prilutsky, O. F.; Rodin, V. G.; Leikov, N. G.; Bielaoussov, A. S.; Dobrian, L. B.; Poluektov, V. P.

    1985-01-01

    French and Soviet specialists have designed and built the gamma-ray telescope GAMMA-1 to detect cosmic gamma rays above 50 MeV. The sensitive area of the detector is 1400 sq cm, energy resolution is 30% at 300 MeV, and angular resolution 1.2 deg at 300 MeV (and less than 20' arc when a coded aperture mask is used). Results on calibration of the qualification model and Monte-Carlo calculations are presented.

  3. Dark Matter Indirect Detection with Gamma Rays

    DOE PAGES

    Patrick Harding, J.

    2017-07-27

    Searches for weakly interacting massive particle (WIMP) dark matter with gamma-ray instruments are a way to get a unique observational handle on the particle nature of dark matter. I will discuss the details of how to perform these searches, both for annihilating and decaying WIMPs. I will discuss the calculation of the gamma-ray flux from possible sources of dark matter annihilation or decay and show examples of limits which have been calculated using these techniques.

  4. Research in cosmic and gamma ray astrophysics

    NASA Technical Reports Server (NTRS)

    Stone, E. C.; Davis, L., Jr.; Mewaldt, R. A.; Prince, T. A.

    1989-01-01

    Research activities in cosmic rays, gamma rays, and astrophysical plasmas are covered. The activities are divided into sections and described, followed by a bibliography. The astrophysical aspects of cosmic rays, gamma rays, and of the radiation and electromagnetic field environment of the Earth and other planets are investigated. These investigations are performed by means of energetic particle and photon detector systems flown on spacecraft and balloons.

  5. Gamma-ray constraints on supernova nucleosynthesis

    NASA Technical Reports Server (NTRS)

    Leising, Mark D.

    1994-01-01

    Gamma-ray spectroscopy holds great promise for probing nucleosynthesis in individual supernova explosions via short-lived radioactivity, and for measuring current global Galactic supernova nucleosynthesis with longer-lived radioactivity. It was somewhat surprising that the former case was realized first for a Type II supernova, when both Co-56 and Co-57 were detected in SN 1987A. These provide unprecedented constraints on models of Type II explosions and nucleosynthesis. Live Al-26 in the Galaxy might come from Type II supernovae, and if it is eventually shown to be so, can constrain massive star evolution, supernova nucleosynthesis, and the Galactic Type II supernova rate. Type Ia supernovae, thought to be thermonuclear explosions, have not yet been detected in gamma-rays. This is somewhat surprising given current models and recent Co-56 detection attempts. Ultimately, gamma-ray measurements can confirm their thermonuclear nature, probe the nuclear burning conditions, and help evaluate their contributions to Galactic nucleosynthesis. Type Ib/c supernovae are poorly understood. Whether they are core collapse or thermonuclear events might be ultimately settled by gamma-ray observations. Depending on details of the nuclear processing, any of these supernova types might contribute to a detectable diffuse glow of Fe-60 gamma-ray lines. Previous attempts at detection have come very close to expected emission levels. Remnants of any type of age less that a few centuries might be detectable as individual spots of Ti-44 gamma-ray line emission. It is in fact quite surprising that previous surveys have not discovered such spots, and the constraints on the combination of nucleosynthesis yields and supernova rates are very interesting. All of these interesting limits and possibilities mean that the next mission, International Gamma-Ray Astrophysics Laboratory (INTEGRAL), if it has sufficient sensitivity, is very likely to lead to the realization of much of the great potential

  6. The Mystery of Gamma-Ray Bursts

    NASA Technical Reports Server (NTRS)

    Fishman, Gerald J.

    1998-01-01

    Gamma-ray bursts remain on of the greatest mysteries in astrophysics in spite of recent observational advances and intense theoretical work. Although some of the basic properties of bursts were known 25 years ago, new and more detailed observations have been made by the BATSE (Burst and Transient Source Experiment) experiment on the Compton Gamma Ray Observatory in the past five years. Recent observations of bursts and some proposed models will be discussed.

  7. Fermi Sees the Gamma Ray Sky

    NASA Image and Video Library

    2017-09-28

    This view of the gamma-ray sky constructed from one year of Fermi LAT observations is the best view of the extreme universe to date. The map shows the rate at which the LAT detects gamma rays with energies above 300 million electron volts -- about 120 million times the energy of visible light -- from different sky directions. Brighter colors equal higher rates. Credit: NASA/DOE/Fermi LAT Collaboration Full story: www.nasa.gov/mission_pages/GLAST/news/first_year.html

  8. Supernovae and gamma-ray bursts connection

    SciTech Connect

    Valle, Massimo Della

    2015-12-17

    I’ll review the status of the Supernova/Gamma-Ray Burst connection. Several pieces of evidence suggest that long duration Gamma-ray Bursts are associated with bright SNe-Ic. However recent works suggest that GRBs might be produced in tight binary systems composed of a massive carbon-oxygen cores and a neutron star companion. Current estimates of the SN and GRB rates yield a ratio GRB/SNe-Ibc in the range ∼ 0.4% − 3%.

  9. Gamma-ray Albedo of the Moon

    SciTech Connect

    Moskalenko, Igor V.; Porter, Troy A.

    2007-06-14

    We use the GEANT4 Monte Carlo framework to calculate the gamma-ray albedo of the Moon due to interactions of cosmic ray (CR) nuclei with moon rock. Our calculation of the albedo spectrum agrees with the EGRET data. We show that the spectrum of gamma-rays from the Moon is very steep with an effective cutoff around 3 GeV (600 MeV for the inner part of the Moon disc). Since it is the only (almost) black spot in the gamma-ray sky, it provides a unique opportunity for calibration of gamma-ray telescopes, such as the forthcoming Gamma Ray Large Area Space Telescope (GLAST). The albedo flux depends on the incident CR spectrum which changes over the solar cycle. Therefore, it is possible to monitor the CR spectrum using the albedo gamma-ray flux. Simultaneous measurements of CR proton and helium spectra by the Payload for Antimatter Matter Exploration and Light-nuclei Astrophysics (PAMELA), and observations of the albedo -rays by the GLAST Large Area Telescope (LAT), can be used to test the model predictions and will enable the GLAST LAT to monitor the CR spectrum near the Earth beyond the lifetime of PAMELA.

  10. Dose-effect relation of interstitial low-dose-rate radiation (Ir192) in an animal tumor model.

    PubMed

    Ruifrok, A C; Levendag, P C; Lakeman, R F; Deurloo, I K; Visser, A G

    1990-01-01

    One way to deliver high doses of radiation to deep seated tumors without damaging the surrounding tissue is by interstitial techniques. This is commonly applied clinically; however, biological data of tumor response to interstitial low-dose-rate gamma irradiation are scarce. Therefore, we have studied the response of rhabdomyosarcoma R1 tumors implanted in the flanks of female Wag/Rij rats using an interstitial Ir192 afterloading system. A template was developed by which four catheters can be implanted in a square geometry with a fixed spacing. Subsequently four Ir192 wires of 2 cm length each are inserted. For dose prescription the highest isodose enveloping the tumor volume was chosen. Interstitial irradiation was performed using tumor volumes of 1500-2000 mm3. A range of minimum tumor doses of 20 up to 115 Gy were given at a mean dose-rate of 48 cGy/hr. Dose-effect relations were obtained from tumor growth curves and tumor cure data, and compared to data from external irradiation. The dose required for 50% cures with interstitial irradiation (TCD50) appears to be 95 +/- 9 Gy. The TCD50 for low-dose-rate interstitial gamma irradiation is 1.5 times the TCD50 for single dose external X ray irradiation at high dose rates, but is comparable to the TCD50 found after fractionated X ray irradiation at high dose rate. Sham treatment of the tumors had no effect on the time needed to reach twice the treatment volume. The growth rate of tumors regrowing after interstitial radiotherapy is not markedly different from the growth rate of untreated (control) tumors (volume doubting time 5.6 +/- 1 day), in contrast to the decreased growth rate after external X ray irradiation. It is argued that the absence of a clear tumor bed effect may be explained by some sparing of the stroma by the low-dose-rate of the interstitial irradiation per se as well as by the physical dose distribution of the interstitial Ir192 sources, giving a relative low dose of radiation to the surrounding

  11. A pneumatic sample changer for gamma-ray spectroscopy

    USGS Publications Warehouse

    Massoni, C.J.; Fones, R.V.; Simon, F.O.

    1973-01-01

    A gravity-feed, pneumatic-ejection sample changer has been developed. The changer is suitable for both flat and well-type detectors and permits the continuous use of gamma-ray spectroscopy equipment 24 h a day, 7 days a week. The electronic circuitry has a fail-safe feature which stops the operation of the changer if a malfunction occurs. ?? 1973 The American Institute of Physics.

  12. High-energy gamma-ray studying with GAMMA-400 after Fermi-LAT

    NASA Astrophysics Data System (ADS)

    Topchiev, N. P.; Galper, A. M.; Bonvicini, V.; Adriani, O.; Arkhangelskaja, I. V.; Arkhangelskiy, A. I.; Bakaldin, A. V.; Bobkov, S. G.; Boezio, M.; Dalkarov, O. D.; Egorov, A. E.; Gorbunov, M. S.; Gusakov, Yu V.; Hnatyk, B. I.; Kadilin, V. V.; Kaplin, V. A.; Kheymits, M. D.; Korepanov, V. E.; Leonov, A. A.; Longo, F.; Mikhailov, V. V.; Mocchiutti, E.; Moiseev, A. A.; Moskalenko, I. V.; Naumov, P. Yu; Picozza, P.; Runtso, M. F.; Serdin, O. V.; Sparvoli, R.; Spillantini, P.; Stozhkov, Yu I.; Suchkov, S. I.; Taraskin, A. A.; Tavani, M.; Yurkin, Yu T.; Zverev, V. G.

    2017-01-01

    Fermi-LAT has made a significant contribution to the study of high-energy gamma-ray diffuse emission and the observation of ∼3000 discrete sources. However, one third of all gamma-ray sources (both galactic and extragalactic) are unidentified, the data on the diffuse gamma-ray emission should be clarified, and signatures of dark matter particles in the high-energy gamma-ray range are not observed up to now. GAMMA-400, currently developing gamma-ray telescope, will have the angular (∼0.01° at 100 GeV) and energy (∼1% at 100 GeV) resolutions in the energy range of 10-1000 GeV better than the Fermi-LAT (as well as ground gamma-ray telescopes) by a factor of 5-10 and observe some regions of the Universe (such as Galactic Center, Fermi Bubbles, Crab, Cygnus, etc.) in the highly elliptic orbit (without shading the telescope by the Earth) continuously for a long time. It will permit to identify many discrete sources, to clarify the structure of extended sources, to specify the data on the diffuse emission, and to resolve gamma rays from dark matter particles.

  13. Dissecting the Gamma-Ray Background in Search of Dark Matter

    SciTech Connect

    Cholis, Ilias; Hooper, Dan; McDermott, Samuel D.

    2014-02-01

    Several classes of astrophysical sources contribute to the approximately isotropic gamma-ray background measured by the Fermi Gamma-Ray Space Telescope. In this paper, we use Fermi's catalog of gamma-ray sources (along with corresponding source catalogs at infrared and radio wavelengths) to build and constrain a model for the contributions to the extragalactic gamma-ray background from astrophysical sources, including radio galaxies, star-forming galaxies, and blazars. We then combine our model with Fermi's measurement of the gamma-ray background to derive constraints on the dark matter annihilation cross section, including contributions from both extragalactic and galactic halos and subhalos. The resulting constraints are competitive with the strongest current constraints from the Galactic Center and dwarf spheroidal galaxies. As Fermi continues to measure the gamma-ray emission from a greater number of astrophysical sources, it will become possible to more tightly constrain the astrophysical contributions to the extragalactic gamma-ray background. We project that with 10 years of data, Fermi's measurement of this background combined with the improved constraints on the astrophysical source contributions will yield a sensitivity to dark matter annihilations that exceeds the strongest current constraints by a factor of ~ 5 - 10.

  14. Dissecting the gamma-ray background in search of dark matter

    SciTech Connect

    Cholis, Ilias; Hooper, Dan; McDermott, Samuel D. E-mail: dhooper@fnal.gov

    2014-02-01

    Several classes of astrophysical sources contribute to the approximately isotropic gamma-ray background measured by the Fermi Gamma-Ray Space Telescope. In this paper, we use Fermi's catalog of gamma-ray sources (along with corresponding source catalogs at infrared and radio wavelengths) to build and constrain a model for the contributions to the extragalactic gamma-ray background from astrophysical sources, including radio galaxies, star-forming galaxies, and blazars. We then combine our model with Fermi's measurement of the gamma-ray background to derive constraints on the dark matter annihilation cross section, including contributions from both extragalactic and galactic halos and subhalos. The resulting constraints are competitive with the strongest current constraints from the Galactic Center and dwarf spheroidal galaxies. As Fermi continues to measure the gamma-ray emission from a greater number of astrophysical sources, it will become possible to more tightly constrain the astrophysical contributions to the extragalactic gamma-ray background. We project that with 10 years of data, Fermi's measurement of this background combined with the improved constraints on the astrophysical source contributions will yield a sensitivity to dark matter annihilations that exceeds the strongest current constraints by a factor of ∼ 5–10.

  15. Supernovae and Gamma-Ray Bursts

    NASA Astrophysics Data System (ADS)

    Livio, Mario; Panagia, Nino; Sahu, Kailash

    2001-07-01

    Participants; Preface; Gamma-ray burst-supernova relation B. Paczynski; Observations of gamma-ray bursts G. Fishman; Fireballs T. Piran; Gamma-ray mechanisms M. Rees; Prompt optical emission from gamma-ray bursts R. Kehoe, C. Akerlof, R. Balsano, S. Barthelmy, J. Bloch, P. Butterworth, D. Casperson, T. Cline, S. Fletcher, F. Frontera, G. Gisler, J. Heise, J. Hills, K. Hurley, B. Lee, S. Marshall, T. McKay, A. Pawl, L. Piro, B. Priedhorsky, J. Szymanski and J. Wren; X-ray afterglows of gamma-ray bursts L. Piro; The first year of optical-IR observations of SN1998bw I. Danziger, T. Augusteijn, J. Brewer, E. Cappellaro, V. Doublier, T. Galama, J. Gonzalez, O. Hainaut, B. Leibundgut, C. Lidman, P. Mazzali, K. Nomoto, F. Patat, J. Spyromilio, M. Turatto, J. Van Paradijs, P. Vreeswijk and J. Walsh; X-ray emission of Supernova 1998bw in the error box of GRB980425 E. Pian; Direct analysis of spectra of type Ic supernovae D. Branch; The interaction of supernovae and gamma-ray bursts with their surroundings R. Chevalier; Magnetars, soft gamma-ray repeaters and gamma-ray bursts A. Harding; Super-luminous supernova remnants Y. -H. Chu, C. -H. Chen and S. -P. Lai; The properties of hypernovae: SNe Ic 1998bw, 1997ef, and SN IIn 1997cy K. Nomoto, P. Mazzali, T. Nakamura, K. Iwanmoto, K. Maeda, T. Suzuki, M. Turatto, I. Danziger and F. Patat; Collapsars, Gamma-Ray Bursts, and Supernovae S. Woosley, A. MacFadyen and A. Heger; Pre-supernova evolution of massive stars N. Panagia and G. Bono; Radio supernovae and GRB 980425 K. Weiler, N. Panagia, R. Sramek, S. Van Dyk, M. Montes and C. Lacey; Models for Ia supernovae and evolutionary effects P. Hoflich and I. Dominguez; Deflagration to detonation A. Khokhlov; Universality in SN Iae and the Phillips relation D. Arnett; Abundances from supernovae F. -K. Thielemann, F. Brachwitz, C. Freiburghaus, S. Rosswog, K. Iwamoto, T. Nakamura, K. Nomoto, H. Umeda, K. Langanke, G. Martinez-Pinedo, D. Dean, W. Hix and M. Strayer; Sne, GRBs, and the

  16. Phase III trial comparing two low dose rates in brachytherapy of cervix carcinoma: Report at two years

    SciTech Connect

    Lambin, P.; Gerbaulet, A.; Kramer, A.; Haie-Meder, C.; Malaise, E.P.; Chassagne, D. ); Scalliet, P. )

    1993-02-15

    This Phase III randomized trial examined the effect of two low dose rates (0.73 or 0.38 Gy[center dot]h[sup [minus]1]) on the local control, survival, relapse-free survival, complications, and secondary effects in the treatment of cervical cancers. A total of 204 Stage Ib or II cervical carcinoma patients were included between January 1985 and September 1988. Treatment consisted of uterovaginal [sup 137]Cs irradiation followed by surgery. The two groups were similar for age, tumor stage and medical or surgical history. Their brachytherapy parameters were also similar (60 Gy pear dimensions, dose to critical organs, total kerma, etc....). There were no differences in the short-term effects or therapeutic outcome. However, overall complications and side effects observed after 6 months were significantly more frequent (p < 0.01) in the higher dose rate group. 40 refs., 4 figs., 6 tabs.

  17. Investigation of bias dependence on enhanced low dose rate sensitivity in SiGe HBTs for space application

    NASA Astrophysics Data System (ADS)

    Sun, Yabin; Fu, Jun; Xu, Jun; Wang, Yudong; Zhou, Wei; Zhang, Wei; Cui, Jie; Li, Gaoqing; Liu, Zhihong

    2014-02-01

    NPN silicon-germanium (SiGe) heterojunction bipolar transistors (HBTs) were exposed to 60Co gamma source at different dose rates under two bias conditions. Excess base currents and normalized current gains are used to quantify performance degradation. Experiment results demonstrate that the lower the dose rate, the more the irradiation damage, and some enhanced low dose rate sensitivity (ELDRS) exists in SiGe HBTs. The ELDRS effect is found to depend highly on the bias condition during exposure, and the transistors with forward active mode exhibit a more serious ELDRS effect compared to the floating case. The performance degradation at different dose rates and bias conditions is compared and discussed, and furthermore the underlying physical mechanisms are analyzed and investigated in detail.

  18. Dose-effect relation of interstitial low-dose-rate radiation (Ir192) in an animal tumor model

    SciTech Connect

    Ruifrok, A.C.; Levendag, P.C.; Lakeman, R.F.; Deurloo, I.K.; Visser, A.G. )

    1990-01-01

    One way to deliver high doses of radiation to deep seated tumors without damaging the surrounding tissue is by interstitial techniques. This is commonly applied clinically; however, biological data of tumor response to interstitial low-dose-rate gamma irradiation are scarce. Therefore, we have studied the response of rhabdomyosarcoma R1 tumors implanted in the flanks of female Wag/Rij rats using an interstitial Ir192 afterloading system. A template was developed by which four catheters can be implanted in a square geometry with a fixed spacing. Subsequently four Ir192 wires of 2 cm length each are inserted. For dose prescription the highest isodose enveloping the tumor volume was chosen. Interstitial irradiation was performed using tumor volumes of 1500-2000 mm3. A range of minimum tumor doses of 20 up to 115 Gy were given at a mean dose-rate of 48 cGy/hr. Dose-effect relations were obtained from tumor growth curves and tumor cure data, and compared to data from external irradiation. The dose required for 50% cures with interstitial irradiation (TCD50) appears to be 95 +/- 9 Gy. The TCD50 for low-dose-rate interstitial gamma irradiation is 1.5 times the TCD50 for single dose external X ray irradiation at high dose rates, but is comparable to the TCD50 found after fractionated X ray irradiation at high dose rate. Sham treatment of the tumors had no effect on the time needed to reach twice the treatment volume. The growth rate of tumors regrowing after interstitial radiotherapy is not markedly different from the growth rate of untreated (control) tumors (volume doubting time 5.6 +/- 1 day), in contrast to the decreased growth rate after external X ray irradiation.

  19. Influence of low-dose and low-dose-rate ionizing radiation on mutation induction in human cells

    NASA Astrophysics Data System (ADS)

    Yatagai, F.; Umebayashi, Y.; Suzuki, M.; Abe, T.; Suzuki, H.; Shimazu, T.; Ishioka, N.; Iwaki, M.; Honma, M.

    This is a review paper to introduce our recent studies on the genetic effects of low-dose and low-dose-rate ionizing radiation (IR). Human lymphoblastoid TK6 cells were exposed to γ-rays at a dose-rate of 1.2 mGy/h (total 30 mGy). The frequency of early mutations (EMs) in the thymidine kinase ( TK) gene locus was determined to be 1.7 × 10 -6, or 1.9-fold higher than the level seen in unirradated controls [Umebayashi, Y., Honma, M., Suzuki, M., Suzuki, H., Shimazu, T., Ishioka, N., Iwaki, M., Yatagai, F., Mutation induction in cultured human cells after low-dose and low-dose-rate γ-ray irradiation: detection by LOH analysis. J. Radiat. Res., 48, 7-11, 2007]. These mutants were then analyzed for loss of heterozygosity (LOH) events. Small interstitial-deletion events were restricted to the TK gene locus and were not observed in EMs in unirradated controls, but they comprised about half of the EMs (8/15) after IR exposure. Because of the low level of exposure to IR, this specific type of event cannot be considered to be the direct result of an IR-induced DNA double strand break (DSB). To better understand the effects of low-level IR exposure, the repair efficiency of site-specific chromosomal DSBs was also examined. The pre γ-irradiation under the same condition did not largely influence the efficiency of DSB repair via end-joining, but enhanced such efficiency via homologous recombination to an about 40% higher level (unpublished data). All these results suggest that DNA repair and mutagenesis can be indirectly influenced by low-dose/dose-rate IR.

  20. An open-source genetic algorithm for determining optimal seed distributions for low-dose-rate prostate brachytherapy.

    PubMed

    McGeachy, P; Madamesila, J; Beauchamp, A; Khan, R

    2015-01-01

    An open source optimizer that generates seed distributions for low-dose-rate prostate brachytherapy was designed, tested, and validated. The optimizer was a simple genetic algorithm (SGA) that, given a set of prostate and urethra contours, determines the optimal seed distribution in terms of coverage of the prostate with the prescribed dose while avoiding hotspots within the urethra. The algorithm was validated in a retrospective study on 45 previously contoured low-dose-rate prostate brachytherapy patients. Dosimetric indices were evaluated to ensure solutions adhered to clinical standards. The SGA performance was further benchmarked by comparing solutions obtained from a commercial optimizer (inverse planning simulated annealing [IPSA]) with the same cohort of 45 patients. Clinically acceptable target coverage by the prescribed dose (V100) was obtained for both SGA and IPSA, with a mean ± standard deviation of 98 ± 2% and 99.5 ± 0.5%, respectively. For the prostate D90, SGA and IPSA yielded 177 ± 8 Gy and 186 ± 7 Gy, respectively, which were both clinically acceptable. Both algorithms yielded reasonable dose to the rectum, with V100 < 0.3 cc. A reduction in dose to the urethra was seen using SGA. SGA solutions showed a slight prostate volume dependence, with smaller prostates (<25 cc) yielding less desirable, although still clinically viable, dosimetric outcomes. SGA plans used, on average, fewer needles than IPSA (21 vs. 24, respectively), which may lead to a reduction in urinary toxicity and edema that alters post-implant dosimetry. An open source SGA was validated that provides a research tool for the brachytherapy community. Copyright © 2015 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved.

  1. The effect of continuous low dose-rate gamma irradiation on cell population kinetics of lymphoid tissue

    NASA Technical Reports Server (NTRS)

    Foster, B. R.

    1973-01-01

    The problem studied involved cell proliferation in mice thymus undergoing irradiation at a dose rate of 10 roetgens/day for 105 days. Specifically, the aim was to determine wheather or not a steady state of cell population can be established for the indicated period of time and what compensatory mechanisms of cell population are involved.

  2. New insights from cosmic gamma rays

    NASA Astrophysics Data System (ADS)

    Roland, Diehl

    2016-04-01

    The measurement of gamma rays from cosmic sources at ~MeV energies is one of the key tools for nuclear astrophysics, in its study of nuclear reactions and their impacts on objects and phenomena throughout the universe. Gamma rays trace nuclear processes most directly, as they originate from nuclear transitions following radioactive decays or high-energy collisions with excitation of nuclei. Additionally, the unique gamma-ray signature from the annihilation of positrons falls into this astronomical window and is discussed here: Cosmic positrons are often produced from β-decays, thus also of nuclear physics origins. The nuclear reactions leading to radioactive isotopes occur inside stars and stellar explosions, which therefore constitute the main objects of such studies. In recent years, both thermonuclear and core-collapse supernova radioactivities have been measured though 56Ni, 56Co, and 44Ti lines, and a beginning has thus been made to complement conventional supernova observations with such measurements of the prime energy sources of supernova light created in their deep interiors. The diffuse radioactive afterglow of massive-star nucleosynthesis in gamma rays is now being exploited towards astrophysical studies on how massive stars feed back their energy and ejecta into interstellar gas, as part of the cosmic cycle of matter through generations of stars enriching the interstellar gas and stars with metals. Large interstellar cavities and superbubbles have been recognised to be the dominating structures where new massive-star ejecta are injected, from 26Al gamma-ray spectroscopy. Also, constraints on the complex interiors of stars derive from the ratio of 60Fe/26Al gamma rays. Finally, the puzzling bulge-dominated intensity distribution of positron annihilation gamma rays is measured in greater detail, but still not understood; a recent microquasar flare provided evidence that such objects may be prime sources for positrons in interstellar space, rather than

  3. Mercuric iodine room temperature gamma-ray detectors

    NASA Technical Reports Server (NTRS)

    Patt, Bradley E.; Markakis, Jeffrey M.; Gerrish, Vernon M.; Haymes, Robert C.; Trombka, Jacob I.

    1990-01-01

    high resolution mercuric iodide room temperature gamma-ray detectors have excellent potential as an essential component of space instruments to be used for high energy astrophysics. Mercuric iodide detectors are being developed both as photodetectors used in combination with scintillation crystals to detect gamma-rays, and as direct gamma-ray detectors. These detectors are highly radiation damage resistant. The list of applications includes gamma-ray burst detection, gamma-ray line astronomy, solar flare studies, and elemental analysis.

  4. Mercuric iodine room temperature gamma-ray detectors

    NASA Technical Reports Server (NTRS)

    Patt, Bradley E.; Markakis, Jeffrey M.; Gerrish, Vernon M.; Haymes, Robert C.; Trombka, Jacob I.

    1990-01-01

    high resolution mercuric iodide room temperature gamma-ray detectors have excellent potential as an essential component of space instruments to be used for high energy astrophysics. Mercuric iodide detectors are being developed both as photodetectors used in combination with scintillation crystals to detect gamma-rays, and as direct gamma-ray detectors. These detectors are highly radiation damage resistant. The list of applications includes gamma-ray burst detection, gamma-ray line astronomy, solar flare studies, and elemental analysis.

  5. Method for on-line evaluation of materials using prompt gamma ray analysis

    DOEpatents

    Akers, Douglas W.

    2009-12-08

    A method for evaluating a material specimen comprises: Mounting a neutron source and a detector adjacent the material specimen; bombarding the material specimen with neutrons from the neutron source to create prompt gamma rays within the material specimen, some of the prompt gamma rays being emitted from the material specimen, some of the prompt gamma rays resulting in the formation of positrons within the material specimen by pair production; collecting positron annihilation data by detecting with the detector at least one emitted annihilation gamma ray resulting from the annihilation of a positron; storing the positron annihilation data on a data storage system for later retrieval and processing; and continuing to collect and store positron annihilation data, the continued collected and stored positron annihilation data being indicative of an accumulation of lattice damage over time.

  6. Search for gamma ray bursts with coincident balloon flights

    NASA Technical Reports Server (NTRS)

    Cline, T. L.; Desai, U. D.; Schmidt, W. K. H.; Teegarden, B. J.

    1976-01-01

    A search was conducted for cosmic gamma ray bursts of small size and of sufficient frequency of occurrence to be detected during a one day observation program. Two similar detectors, successfully balloon-borne from launch sites in South Dakota and Texas, achieved about 20 hours of simultaneous operation at several millibars atmospheric depth, with continuous separation of over 1,500 km. Fluctuations of the counting rates of less than 150 keV photons with temporal structures from microseconds to several minutes were compared in order to detect coincident or associated responses from the two instruments. No coincident gamma-ray burst events were detected. The resulting integral size spectrum of small bursts, from this and from all other searches, remains a spectrum of upper limits, consistent with an extrapolation of the size spectrum of the largest known bursts, fitting a power low of index -1.5.

  7. Diffuse continuum gamma rays from the Galaxy observed by COMPTEL

    NASA Technical Reports Server (NTRS)

    Strong, A. W.; Bennett, K.; Bloemen, H.; Diehl, R.; Hermsen, W.; Morris, D.; Schonfelder, V.; Stacy, J. G.; De Vries, C.; Varendorff, M.

    1994-01-01

    The diffuse Galactic continuum gamma-ray emission has been studied using the full Sky Survey from COMPTEL on the Compton Observatory CGRO. The diffuse emission appears to be visible in the whole 0.75-30 MeV range covered by the instrument, although a considerable contribution from unresolved point sources cannot be excluded. A correlation analysis using HI and CO surveys of the Galaxy is used to derive the Galactic emissivity spectrum, and this is consistent with a smooth continuation to the spectrum at higher energies derived by a similar analysis of COS-B data. The apparent conversion factor from integrated CO temperature to molecular hydrogen column density can also be determined from the correlation analysis. The value obtained is consistent with results from COS-B and other non-gamma-ray methods. Calculations of the emissivity spectrum from bremsstrahlung from a cosmic-ray electron spectrum based on propagation models are compared with the observations.

  8. Dose equivalence for high-dose-rate to low-dose-rate intracavitary irradiation in the treatment of cancer of the uterine cervix

    SciTech Connect

    Akine, Y.; Tokita, N.; Ogino, T.; Kajiura, Y.; Tsukiyama, I.; Egawa, S. )

    1990-12-01

    By comparing the incidence of major radiation injury, we estimated doses clinically equivalent for high-dose-rate (HDR) to conventional low-dose-rate (LDR) intracavitary irradiation in patients with Stages IIb and IIIb cancer of the uterine cervix. We reviewed a total of 300 patients who were treated with external beam therapy to the pelvis (50 Gy in 5 weeks) followed either by low-dose-rate (253 patients) or high-dose-rate (47 patients) intracavitary treatment. The high-dose-rate intracavitary treatment was given 5 Gy per session to point A, 4 fractions in 2 weeks, with a total dose of 20 Gy. The low-dose-rate treatment was given with one or two application(s) delivering 11-52 Gy to the point A. The local control rates were similar in both groups. The incidence of major radiation injury requiring surgical intervention were 5.1% (13/253) and 4.3% (2/47) for low-dose-rate and high-dose-rate groups, respectively. The 4.3% incidence corresponded to 29.8 Gy with low-dose-rate irradiation, thus, it was concluded that the clinically equivalent dose for high-dose-rate irradiation was approximately 2/3 (20/29.8) of the dose used in low-dose-rate therapy.

  9. The GAMMA-400 gamma-ray telescope for precision gamma-ray emission investigations

    NASA Astrophysics Data System (ADS)

    Topchiev, N. P.; Galper, A. M.; Bonvicini, V.; Adriani, O.; Aptekar, R. L.; Arkhangelskaja, I. V.; Arkhangelskiy, A. I.; Bakaldin, A. V.; Bergstrom, L.; Berti, E.; Bigongiari, G.; Bobkov, S. G.; Boezio, M.; Bogomolov, E. A.; Bonechi, L.; Bongi, M.; Bottai, S.; Castellini, G.; Cattaneo, P. W.; Cumani, P.; Dalkarov, O. D.; Dedenko, G. L.; De Donato, C.; Dogiel, V. A.; Finetti, N.; Gascon, D.; Gorbunov, M. S.; Gusakov, Yu V.; Hnatyk, B. I.; Kadilin, V. V.; Kaplin, V. A.; Kaplun, A. A.; Kheymits, M. D.; Korepanov, V. E.; Larsson, J.; Leonov, A. A.; Loginov, V. A.; Longo, F.; Maestro, P.; Marrocchesi, P. S.; Martinez, M.; Men'shenin, A. L.; Mikhailov, V. V.; Mocchiutti, E.; Moiseev, A. A.; Mori, N.; Moskalenko, I. V.; Naumov, P. Yu; Papini, P.; Paredes, J. M.; Pearce, M.; Picozza, P.; Rappoldi, A.; Ricciarini, S.; Runtso, M. F.; Ryde, F.; Serdin, O. V.; Sparvoli, R.; Spillantini, P.; Stozhkov, Yu I.; Suchkov, S. I.; Taraskin, A. A.; Tavani, M.; Tiberio, A.; Tyurin, E. M.; Ulanov, M. V.; Vacchi, A.; Vannuccini, E.; Vasilyev, G. I.; Ward, J. E.; Yurkin, Yu T.; Zampa, N.; Zirakashvili, V. N.; Zverev, V. G.

    2016-02-01

    The GAMMA-400 gamma-ray telescope with excellent angular and energy resolutions is designed to search for signatures of dark matter in the fluxes of gamma-ray emission and electrons + positrons. Precision investigations of gamma-ray emission from Galactic Center, Crab, Vela, Cygnus, Geminga, and other regions will be performed, as well as diffuse gamma-ray emission, along with measurements of high-energy electron + positron and nuclei fluxes. Furthermore, it will study gamma-ray bursts and gamma-ray emission from the Sun during periods of solar activity. The GAMMA-400 energy range is expected to be from ∼20 MeV up to TeV energies for gamma rays, up to 10 TeV for electrons + positrons, and up to 1015 eV for cosmic-ray nuclei. For 100-GeV gamma rays, the GAMMA-400 angular resolution is ∼0.01° and energy resolution is ∼1% the proton rejection factor is ∼5x105. GAMMA-400 will be installed onboard the Russian space observatory.

  10. Long-term variations in the gamma-ray background on SMM

    NASA Technical Reports Server (NTRS)

    Kurfess, J. D.; Share, G. H.; Kinzer, R. L.; Johnson, W. N.; Adams, J. H., Jr.

    1989-01-01

    Long-term temporal variations in the various components of the background radiation detected by the gamma-ray spectrometer on the Solar Maximum Mission are presented. The SMM gamma-ray spectrometer was launched in February, 1980 and continues to operate normally. The extended period of mission operations has provided a large data base in which it is possible to investigate a variety of environmental and instrumental background effects. In particular, several effects associated with orbital precession are introduced and discussed.

  11. The Compton Gamma Ray Observatory: highlights from the first three years of the mission.

    NASA Astrophysics Data System (ADS)

    Gehrels, N.; Shrader, C.; Kniffen, D. A.

    The Arthur Holly Compton Gamma Ray observatory is the second in NASA's series of Great Observatories. It has been in operation for over three years, and has given a dramatic increase in capability over previous gamma-ray missions. The spacecraft and scientific instruments continue to function nearly flawlessly, and many significant discoveries have been made. The authors describe the capabilities of the four scientific instruments, and highlight some of the results from the first three years of the mission.

  12. Study of the Gamma-Ray Binary LS5039 with Suzaku

    SciTech Connect

    Takahashi, Tadayuki; Kishishita, Tetsuichi; Khangulyan, Dmitry; Aharonian, Felix A.; Bosch-Ramon, Valenti; Hinton, Jim A.

    2010-07-15

    The Suzaku data of the galactic binary source LS 5039, which have continuous coverage of more than one orbital period, show strong modulation of the X-ray emission at the orbital period of this TeV gamma-ray emitting system. The X-ray radiation of LS 5039 is likely to be linked to very-high-energy electrons which are also responsible for the TeV gamma-ray emission.

  13. Stellar Photon Archaeology with Gamma-Rays

    NASA Technical Reports Server (NTRS)

    Stecker, Floyd W.

    2009-01-01

    Ongoing deep surveys of galaxy luminosity distribution functions, spectral energy distributions and backwards evolution models of star formation rates can be used to calculate the past history of intergalactic photon densities and, from them, the present and past optical depth of the Universe to gamma-rays from pair production interactions with these photons. The energy-redshift dependence of the optical depth of the Universe to gamma-rays has become known as the Fazio-Stecker relation (Fazio & Stecker 1970). Stecker, Malkan & Scully have calculated the densities of intergalactic background light (IBL) photons of energies from 0.03 eV to the Lyman limit at 13.6 eV and for 0$ < z < $6, using deep survey galaxy observations from Spitzer, Hubble and GALEX and have consequently predicted spectral absorption features for extragalactic gamma-ray sources. This procedure can also be reversed. Determining the cutoff energies of gamma-ray sources with known redshifts using the recently launched Fermi gamma-ray space telescope may enable a more precise determination of the IBL photon densities in the past, i.e., the "archaeo-IBL.", and therefore allow a better measure of the past history of the total star formation rate, including that from galaxies too faint to be observed.

  14. Gamma-ray limits on neutrino lines

    SciTech Connect

    Queiroz, Farinaldo S.; Yaguna, Carlos E.; Weniger, Christoph

    2016-05-23

    Monochromatic neutrinos from dark matter annihilations (χχ→νν-bar) are always produced in association with a gamma-ray spectrum generated by electroweak bremsstrahlung. Consequently, these neutrino lines can be searched for not only with neutrino detectors but also indirectly with gamma-ray telescopes. Here, we derive limits on the dark matter annihilation cross section into neutrinos based on recent Fermi-LAT and HESS data. We find that, for dark matter masses above 200 GeV, gamma-ray data actually set the most stringent constraints on neutrino lines from dark matter annihilation and, therefore, an upper bound on the dark matter total annihilation cross section. In addition, we point out that gamma-ray telescopes, unlike neutrino detectors, have the potential to distinguish the flavor of the final state neutrino. Our results indicate that we have already entered into a new era where gamma-ray telescopes are more sensitive than neutrino detectors to neutrino lines from dark matter annihilation.

  15. Stellar Photon Archaeology with Gamma-Rays

    NASA Technical Reports Server (NTRS)

    Stecker, Floyd W.

    2009-01-01

    Ongoing deep surveys of galaxy luminosity distribution functions, spectral energy distributions and backwards evolution models of star formation rates can be used to calculate the past history of intergalactic photon densities and, from them, the present and past optical depth of the Universe to gamma-rays from pair production interactions with these photons. The energy-redshift dependence of the optical depth of the Universe to gamma-rays has become known as the Fazio-Stecker relation (Fazio & Stecker 1970). Stecker, Malkan & Scully have calculated the densities of intergalactic background light (IBL) photons of energies from 0.03 eV to the Lyman limit at 13.6 eV and for 0$ < z < $6, using deep survey galaxy observations from Spitzer, Hubble and GALEX and have consequently predicted spectral absorption features for extragalactic gamma-ray sources. This procedure can also be reversed. Determining the cutoff energies of gamma-ray sources with known redshifts using the recently launched Fermi gamma-ray space telescope may enable a more precise determination of the IBL photon densities in the past, i.e., the "archaeo-IBL.", and therefore allow a better measure of the past history of the total star formation rate, including that from galaxies too faint to be observed.

  16. LUMINOSITY EVOLUTION OF GAMMA-RAY PULSARS

    SciTech Connect

    Hirotani, Kouichi

    2013-04-01

    We investigate the electrodynamic structure of a pulsar outer-magnetospheric particle accelerator and the resulting gamma-ray emission. By considering the condition for the accelerator to be self-sustained, we derive how the trans-magnetic-field thickness of the accelerator evolves with the pulsar age. It is found that the thickness is small but increases steadily if the neutron-star envelope is contaminated by sufficient light elements. For such a light element envelope, the gamma-ray luminosity of the accelerator is kept approximately constant as a function of age in the initial 10,000 yr, forming the lower bound of the observed distribution of the gamma-ray luminosity of rotation-powered pulsars. If the envelope consists of only heavy elements, on the other hand, the thickness is greater, but it increases less rapidly than a light element envelope. For such a heavy element envelope, the gamma-ray luminosity decreases relatively rapidly, forming the upper bound of the observed distribution. The gamma-ray luminosity of a general pulsar resides between these two extreme cases, reflecting the envelope composition and the magnetic inclination angle with respect to the rotation axis. The cutoff energy of the primary curvature emission is regulated below several GeV even for young pulsars because the gap thickness, and hence the acceleration electric field, is suppressed by the polarization of the produced pairs.

  17. On Gamma-Ray Bursts

    NASA Astrophysics Data System (ADS)

    Ruffini, R.; Bernardini, M. G.; Bianco, C. L.; Caito, L.; Chardonnet, P.; Cherubini, C.; Dainotti, M. G.; Fraschetti, F.; Geralico, A.; Guida, R.; Patricelli, B.; Rotondo, M.; Rueda Hernandez, J. A.; Vereshchagin, G.; Xue, S.-S.

    2008-09-01

    We show by example how the uncoding of Gamma-Ray Bursts (GRBs) offers unprecedented possibilities to foster new knowledge in fundamental physics and in astrophysics. After recalling some of the classic work on vacuum polarization in uniform electric fields by Klein, Sauter, Heisenberg, Euler and Schwinger, we summarize some of the efforts to observe these effects in heavy ions and high energy ion collisions. We then turn to the theory of vacuum polarization around a Kerr-Newman black hole, leading to the extraction of the blackholic energy, to the concept of dyadosphere and dyadotorus, and to the creation of an electron-positron-photon plasma. We then present a new theoretical approach encompassing the physics of neutron stars and heavy nuclei. It is shown that configurations of nuclear matter in bulk with global charge neutrality can exist on macroscopic scales and with electric fields close to the critical value near their surfaces. These configurations may represent an initial condition for the process of gravitational collapse, leading to the creation of an electron-positron-photon plasma: the basic self-accelerating system explaining both the energetics and the high energy Lorentz factor observed in GRBs. We then turn to recall the two basic interpretational paradigms of our GRB model: 1) the Relative Space-Time Transformation (RSTT) paradigm and 2) the Interpretation of the Burst Structure (IBS) paradigm. These paradigms lead to a "canonical" GRB light curve formed from two different components: a Proper-GRB (P-GRB) and an extended afterglow comprising a raising part, a peak, and a decaying tail. When the P-GRB is energetically predominant we have a "genuine" short GRB, while when the afterglow is energetically predominant we have a so-called long GRB or a "fake" short GRB. We compare and contrast the description of the relativistic expansion of the electron-positron plasma within our approach and within the other ones in the current literature. We then turn

  18. The measurement of gamma ray induced heating in a mixed neutron and gamma ray environment

    SciTech Connect

    Chiu, H.K.

    1991-10-01

    The problem of measuring the gamma heating in a mixed DT neutron and gamma ray environment was explored. A new detector technique was developed to make this measurement. Gamma heating measurements were made in a low-Z assembly irradiated with 14-Mev neutrons and (n, n{prime}) gammas produced by a Texas Nuclear Model 9400 neutron generator. Heating measurements were made in the mid-line of the lattice using a proportional counter operating in the Continuously-varied Bias-voltage Acquisition mode. The neutron-induced signal was separated from the gamma-induced signal by exploiting the signal rise-time differences inherent to radiations of different linear energy transfer coefficient, which are observable in a proportional counter. The operating limits of this measurement technique were explored by varying the counter position in the low-Z lattice, hence changing the irradiation spectrum observed. The experiment was modelled numerically to help interpret the measured results. The transport of neutrons and gamma rays in the assembly was modelled using the one- dimensional radiation transport code ANISN/PC. The cross-section set used for these calculations was derived from the ENDF/B-V library using the code MC{sup 2}-2 for the case of DT neutrons slowing down in a low-Z material. The calculated neutron and gamma spectra in the slab and the relevant mass-stopping powers were used to construct weighting factors which relate the energy deposition in the counter fill-gas to that in the counter wall and in the surrounding material. The gamma energy deposition at various positions in the lattice is estimated by applying these weighting factors to the measured gamma energy deposition in the counter at those locations.

  19. Gamma ray pulsars. [electron-photon cascades

    NASA Technical Reports Server (NTRS)

    Oegelman, H.; Ayasli, S.; Hacinliyan, A.

    1977-01-01

    Data from the SAS-2 high-energy gamma-ray experiment reveal the existence of four pulsars emitting photons above 35 MeV. An attempt is made to explain the gamma-ray emission from these pulsars in terms of an electron-photon cascade that develops in the magnetosphere of the pulsar. Although there is very little material above the surface of the pulsar, the very intense magnetic fields (10 to the 12th power gauss) correspond to many radiation lengths which cause electrons to emit photons by magnetic bremsstrahlung and which cause these photons to pair-produce. The cascade develops until the mean photon energy drops below the pair-production threshold which is in the gamma-ray range; at this stage, the photons break out from the source.

  20. Fuzzy correlations of gamma-ray bursts

    NASA Technical Reports Server (NTRS)

    Hartmann, Dieter H.; Linder, Eric V.; Blumenthal, George R.

    1991-01-01

    The origin of gamma-ray bursts is not known, both in the sense of the nature of the source emitting the radiation and literally, the position of the burst on the sky. Lacking unambiguously identified counterparts in any wavelength band studied to date, statistical approaches are required to determine the burster distance scale. Angular correlation analysis is one of the most powerful tools in this regard. However, poor detector resolution gives large localization errors, effectively beam smearing the positions. The resulting fuzzy angular correlation function is investigated and the generic isotropization that smearing induces on any intrinsic clustering is discussed. In particular, the extent to which gamma-ray burst observations by the BATSE detector aboard the Gamma-Ray Observatory might recover an intrinsic source correlation is investigated.

  1. Gamma-Ray Imaging for Explosives Detection

    NASA Technical Reports Server (NTRS)

    deNolfo, G. A.; Hunter, S. D.; Barbier, L. M.; Link, J. T.; Son, S.; Floyd, S. R.; Guardala, N.; Skopec, M.; Stark, B.

    2008-01-01

    We describe a gamma-ray imaging camera (GIC) for active interrogation of explosives being developed by NASA/GSFC and NSWCICarderock. The GIC is based on the Three-dimensional Track Imager (3-DTI) technology developed at GSFC for gamma-ray astrophysics. The 3-DTI, a large volume time-projection chamber, provides accurate, approx.0.4 mm resolution, 3-D tracking of charged particles. The incident direction of gamma rays, E, > 6 MeV, are reconstructed from the momenta and energies of the electron-positron pair resulting from interactions in the 3-DTI volume. The optimization of the 3-DTI technology for this specific application and the performance of the GIC from laboratory tests is presented.

  2. Gamma ray lines from buried supernovae

    NASA Technical Reports Server (NTRS)

    Morfill, G. E.; Meyer, P.

    1982-01-01

    An investigation is conducted concerning the possibility that supernovae (SN), located in dense interstellar clouds, might become the sources of gamma ray lines. The SN progenitor, in such a case, has to be an O or B star so that its evolutionary lifetime is short, and an explosion inside the cloud is still possible. It is shown that, in principle, a measurement of the abundances in the ejecta is possible. Attention is given to the characteristics of a model, the expected luminosity of gamma-ray lines, and the study of specific numerical examples for testing the feasibility of the considered mechanism. On the basis of the obtained results, it is concluded that gamma-ray line production by collisional excitation in confined supernovae remnants may be quite important.

  3. Tycho's Star Shines in Gamma Rays

    NASA Image and Video Library

    2017-09-27

    NASA image relase December 13, 2011 Gamma-rays detected by Fermi's LAT show that the remnant of Tycho's supernova shines in the highest-energy form of light. This portrait of the shattered star includes gamma rays (magenta), X-rays (yellow, green, and blue), infrared (red) and optical data. Credit: Gamma ray, NASA/DOE/Fermi LAT Collaboration; X-ray, NASA/CXC/SAO; Infrared, NASA/JPL-Caltech; Optical, MPIA, Calar Alto, O. Krause et al. and DSS To read more go to: www.nasa.gov/mission_pages/GLAST/news/tycho-star.html NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

  4. Gamma Rays at Very High Energies

    NASA Astrophysics Data System (ADS)

    Aharonian, Felix

    This chapter presents the elaborated lecture notes on Gamma Rays at Very High Energies given by Felix Aharonian at the 40th Saas-Fee Advanced Course on "Astrophysics at Very High Energies". Any coherent description and interpretation of phenomena related to gammarays requires deep knowledge of many disciplines of physics like nuclear and particle physics, quantum and classical electrodynamics, special and general relativity, plasma physics, magnetohydrodynamics, etc. After giving an introduction to gamma-ray astronomy the author discusses the astrophysical potential of ground-based detectors, radiation mechanisms, supernova remnants and origin of the galactic cosmic rays, TeV emission of young supernova remnants, gamma-emission from the Galactic center, pulsars, pulsar winds, pulsar wind nebulae, and gamma-ray loud binaries.

  5. Microsecond flares in gamma-ray bursts

    NASA Technical Reports Server (NTRS)

    Schaefer, Bradley E.; Cohen, Justin; Teegarden, Bonnard J.; Cline, Thomas L.; Fishman, Gerald J.; Meegan, Charles A.; Wilson, Robert B.; Paciesas, William S.; Pendleton, Geoffrey N.; Matteson, James L.

    1993-01-01

    It has been suggested that gamma-ray burst light curves may consist of many superposed flares with a duration shorter than 30/microsec. If true, the implications for the interpretation of burst data are enormous. With the launch of the Compton Gamma-Ray Observatory, four predictions of Mitrofanov's (1989) suggestion can be tested. Our results which contradict this suggestion are (1) the photon arrival times are not correlated between independent detectors, (2) the spectral hardness and intensity does not depend on the detector area, (3) the bursts seen by detectors which measure photon positions do not see microsecond flares, and (4) burst positions deduced from detectors with different projected areas are close to the positions deduced from time-of-flight differences between separated spacecraft. We conclude, therefore, that gamma-ray bursts are not composed of microsecond flares.

  6. Technology Needs for Gamma Ray Astronomy

    NASA Technical Reports Server (NTRS)

    Gehrels, Neil

    2011-01-01

    Gamma ray astronomy is currently in an exciting period of multiple missions and a wealth of data. Results from INTEGRAL, Fermi, AGILE, Suzaku and Swift are making large contributions to our knowledge of high energy processes in the universe. The advances are due to new detector and imaging technologies. The steps to date have been from scintillators to solid state detectors for sensors and from light buckets to coded aperture masks and pair telescopes for imagers. A key direction for the future is toward focusing telescopes pushing into the hard X-ray regime and Compton telescopes and pair telescopes with fine spatial resolution for medium and high energy gamma rays. These technologies will provide finer imaging of gamma-ray sources. Importantly, they will also enable large steps forward in sensitivity by reducing background.

  7. Gamma rays and neutrons from solar flares

    NASA Astrophysics Data System (ADS)

    Murphy, R. J.

    Recent observations with the Gamma-Ray Spectrometer (GRS) on the Solar Maximum Mission (SMM), along with observations from a number of ground-based and spacecraft detectors, contain a wealth of information on particle acceleration in solar flares. The analysis and interpretation of this data is crucial to the understanding of the flare process. A general analysis of gamma-ray and neutron production in solar flared and a comparison of theoretical calculations with data are presented. An overview of the flare phenomenon is given, recent gamma-ray and particle observations are discussed, the theory of each production process is reviewed and detailed calculations are presented, and a comparison of these calculations with data is made.

  8. Gamma-Ray Bursts Search with HAWC

    NASA Astrophysics Data System (ADS)

    de Leon, Cederik; Salazar Ibarguen, Humberto; Villaseã+/-Or Cendejas, Luis Manuel; HAWC Collaboration

    2017-01-01

    The High Altitude Water Cherenkov (HAWC) Gamma-ray observatory is a wide field-of-view observatory sensitive to gamma rays in the 100 GeV - 100 TeV energy range, located in Mexico at an altitude of 4100 m. In the present work we present results on the search for excesses in the rates of signals from the individual photomultiplier tubes (PMTs) using the Time to Digital Converters (TDC) of HAWC. This search is based on the implementation of the Moving Average Ratio Analysis (MARA) focused on the characterization of the different physical phenomena that may give rise to such excesses: noise in the PMTs, atmospheric conditions related with thunderstorms and excesses of astrophysical origin such as variable sources of high energy gamma rays and in particular GRBs. In particular we present an analysis over the HAWC historical data for the search of such excesses and elaborate on the possible physical interpretation of the found excesses.

  9. An Overview of the XGAM Code and Related Software for Gamma-ray Analysis

    SciTech Connect

    Younes, W.

    2014-11-13

    The XGAM spectrum-fitting code and associated software were developed specifically to analyze the complex gamma-ray spectra that can result from neutron-induced reactions. The XGAM code is designed to fit a spectrum over the entire available gamma-ray energy range as a single entity, in contrast to the more traditional piecewise approaches. This global-fit philosophy enforces background continuity as well as consistency between local and global behavior throughout the spectrum, and in a natural way. This report presents XGAM and the suite of programs built around it with an emphasis on how they fit into an overall analysis methodology for complex gamma-ray data. An application to the analysis of time-dependent delayed gamma-ray yields from 235U fission is shown in order to showcase the codes and how they interact.

  10. A Search for Microsecond Gamma Ray Bursts From Primordial Black Holes

    SciTech Connect

    Frank Krennrich

    2004-08-12

    The project is called SGARFACE (Short Gamma Ray Front Air Cherenkov Experiment) and is an atmospheric Cherenkov detector to provide sensitivity to short bursts of gamma rays of extraterrestrial origin. The detector is an addition to the Whipple 10m gamma ray telescope on Mt. Hopkins in southern Arizona and uses a digital trigger module for recognizing Cherenkov light flashes from gamma ray bursts. The digital trigger modules have been designed, tested and constructed at Iowa State University and have been installed at the Whipple 10m telescope. Operation of the experiment started in March 2003 and data collecting will likely continue until spring of 2005. A final results paper addressing a search for primordial black holes is likely to be finished by summer of 2005.

  11. THE GALACTIC POPULATION OF YOUNG {gamma}-RAY PULSARS

    SciTech Connect

    Watters, Kyle P.; Romani, Roger W. E-mail: rwr@astro.stanford.edu

    2011-02-01

    We have simulated a Galactic population of young pulsars and compared with the Fermi LAT sample, constraining the birth properties, beaming and evolution of these spin-powered objects. Using quantitative tests of agreement with the distributions of observed spin and pulse properties, we find that short birth periods P{sub 0} {approx} 50 ms and {gamma}-ray beams arising in the outer magnetosphere, dominated by a single pole, are strongly preferred. The modeled relative numbers of radio-detected and radio-quiet objects agrees well with the data. Although the sample is local, extrapolation to the full Galaxy implies a {gamma}-ray pulsar birthrate 1/(59 yr). This is shown to be in good agreement with the estimated Galactic core collapse rate and with the local density of OB star progenitors. We give predictions for the numbers of expected young pulsar detections if Fermi LAT observations continue 10 years. In contrast to the potentially significant contribution of unresolved millisecond pulsars, we find that young pulsars should contribute little to the Galactic {gamma}-ray background.

  12. Gamma Ray Burst 150518a measured at different wavelengths

    NASA Astrophysics Data System (ADS)

    Apala, Ellizabeth Ann; Soderberg, Alicia Margarita; West, Michael

    2016-01-01

    Gamma Ray Burst (GRB's), extremely energetic flashes of Gamma Rays, are caused by either deaths of massive unstable stars or colliding binary neutron stars. A unique burst, GRB 150518a, had two recorded bursts fifteen minutes apart which is very rare and is considered to be ultra-long, lasting around thirty minutes total and is associated with a Supernova explosion. GBR 150518a is also extremely close compared to the average burst being measured to have a redshift of .2, this is important to note because GRB's measuring less than a redshift of .3 only are seen every ten years. Gamma rays are emitted by supernovae, neutron stars, black holes, and quasars and by studying GRB's it allows us to see more deeply into how these objects function. The first few days of GRB 150518as' detected afterglow was plotted in different wavelengths, including optical, x-ray, radio, and infrared, in flux verses time. Data is continuously being added as time goes on. This research is funded by the NSF, grant number 1358990.

  13. First Results from the HAWC Gamma-Ray Observatory

    NASA Astrophysics Data System (ADS)

    Salesa Greus, Francisco; HAWC Collaboration

    2016-04-01

    The High Altitude Water Cherenkov (HAWC) Observatory is a TeV gamma-ray detector located at an altitude of 4100 meters on the northern slope of the Sierra Negra volcano in the state of Puebla, Mexico. The detector will consist of 300 water Cherenkov detectors spread on a 22,000 square meter area, and is expected to be fully constructed by the end of 2014. Thanks to its large field-of-view, good angular resolution and >90% duty cycle, HAWC will allow us to study the Galactic sources at high energies (100 GeV - 100 TeV), diffuse gamma-ray emission, and transient emissions from active galactic nuclei and gamma-ray bursts. The detector started its continuous operation in August 2013 with a fraction of the array, and its size has been increasing since then. The first results of the experiment, with almost one year of data from the partial array, are reviewed in this proceedings.

  14. The evaluated gamma-ray activation file (EGAF)

    SciTech Connect

    Firestone, R.B.; Molnar, G.L.; Revay, Zs.; Belgya, T.; McNabb, D.P.; Sleaford, B.W.

    2004-09-22

    The Evaluated Gamma-ray Activation File (EGAF), a new database of prompt and delayed neutron capture g-ray cross sections, has been prepared as part of an International Atomic Energy Agency (IAEA) Coordinated Research Project to develop a ''Database of Prompt Gamma-rays from Slow Neutron Capture for Elemental Analysis.'' Recent elemental g-ray cross-section measurements performed with the guided neutron beam at the Budapest Reactor have been combined with data from the literature to produce the EGAF database. EGAF contains thermal cross sections for {approx} 35,000 prompt and delayed g-rays from 262 isotopes. New precise total thermal radiative cross sections have been derived for many isotopes from the primary and secondary gamma-ray cross sections and additional level scheme data. An IAEA TECDOC describing the EGAF evaluation and tabulating the most prominent g-rays will be published in 2004. The TECDOC will include a CD-ROM containing the EGAF database in both ENSDF and tabular formats with an interactive viewer for searching and displaying the data. The Isotopes Project, Lawrence Berkeley National Laboratory continues to maintain and update the EGAF file. These data are available on the Internet from both the IAEA and Isotopes Project websites.

  15. Low-Dose-Rate Californium-252 Neutron Intracavitary Afterloading Radiotherapy Combined With Conformal Radiotherapy for Treatment of Cervical Cancer

    SciTech Connect

    Zhang Min; Xu Hongde; Pan Songdan; Lin Shan; Yue Jianhua; Liu Jianren

    2012-07-01

    Purpose: To study the efficacy of low-dose-rate californium-252 ({sup 252}Cf) neutron intracavitary afterloading radiotherapy (RT) combined with external pelvic RT for treatment of cervical cancer. Methods and Materials: The records of 96 patients treated for cervical cancer from 2006 to 2010 were retrospectively reviewed. For patients with tumors {<=}4 cm in diameter, external beam radiation was performed (1.8 Gy/day, five times/week) until the dose reached 20 Gy, and then {sup 252}Cf neutron intracavitary afterloading RT (once/week) was begun, and the frequency of external beam radiation was changed to four times/week. For patients with tumors >4 cm, {sup 252}Cf RT was performed one to two times before whole-pelvis external beam radiation. The tumor-eliminating dose was determined by using the depth limit of 5 mm below the mucosa as the reference point. In all patients, the total dose of the external beam radiation ranged from 46.8 to 50 Gy. For {sup 252}Cf RT, the dose delivered to point A was 6 Gy/fraction, once per week, for a total of seven times, and the total dose was 42 Gy. Results: The mean {+-} SD patient age was 54.7 {+-} 13.7 years. Six patients had disease assessed at stage IB, 13 patients had stage IIA, 49 patients had stage IIB, 3 patients had stage IIIA, 24 patients had stage IIIB, and 1 patient had stage IVA. All patients obtained complete tumor regression (CR). The mean {+-} SD time to CR was 23.5 {+-} 3.4 days. Vaginal bleeding was fully controlled in 80 patients within 1 to 8 days. The mean {+-} SD follow-up period was 27.6 {+-} 12.7 months (range, 6-48 months). Five patients died due to recurrence or metastasis. The 3-year survival and disease-free recurrence rates were 89.6% and 87.5 %, respectively. Nine patients experienced mild radiation proctitis, and 4 patients developed radiocystitis. Conclusions: Low-dose-rate {sup 252}Cf neutron RT combined with external pelvic RT is effective for treating cervical cancer, with a low incidence of

  16. Low-dose-rate californium-252 neutron intracavitary afterloading radiotherapy combined with conformal radiotherapy for treatment of cervical cancer.

    PubMed

    Zhang, Min; Xu, Hong-De; Pan, Song-Dan; Lin, Shan; Yue, Jian-Hua; Liu, Jian-Ren

    2012-07-01

    To study the efficacy of low-dose-rate californium-252 ((252)Cf) neutron intracavitary afterloading radiotherapy (RT) combined with external pelvic RT for treatment of cervical cancer. The records of 96 patients treated for cervical cancer from 2006 to 2010 were retrospectively reviewed. For patients with tumors ≤4 cm in diameter, external beam radiation was performed (1.8 Gy/day, five times/week) until the dose reached 20 Gy, and then (252)Cf neutron intracavitary afterloading RT (once/week) was begun, and the frequency of external beam radiation was changed to four times/week. For patients with tumors >4 cm, (252)Cf RT was performed one to two times before whole-pelvis external beam radiation. The tumor-eliminating dose was determined by using the depth limit of 5 mm below the mucosa as the reference point. In all patients, the total dose of the external beam radiation ranged from 46.8 to 50 Gy. For (252)Cf RT, the dose delivered to point A was 6 Gy/fraction, once per week, for a total of seven times, and the total dose was 42 Gy. The mean ± SD patient age was 54.7 ± 13.7 years. Six patients had disease assessed at stage IB, 13 patients had stage IIA, 49 patients had stage IIB, 3 patients had stage IIIA, 24 patients had stage IIIB, and 1 patient had stage IVA. All patients obtained complete tumor regression (CR). The mean ± SD time to CR was 23.5 ± 3.4 days. Vaginal bleeding was fully controlled in 80 patients within 1 to 8 days. The mean ± SD follow-up period was 27.6 ± 12.7 months (range, 6-48 months). Five patients died due to recurrence or metastasis. The 3-year survival and disease-free recurrence rates were 89.6% and 87.5 %, respectively. Nine patients experienced mild radiation proctitis, and 4 patients developed radiocystitis. Low-dose-rate (252)Cf neutron RT combined with external pelvic RT is effective for treating cervical cancer, with a low incidence of complications. Copyright © 2012 Elsevier Inc. All rights reserved.

  17. Gamma ray line observations with OSSE

    NASA Technical Reports Server (NTRS)

    Kurfess, J. D.; Grove, J. E.; Johnson, W. N.; Murphy, R. J.; Share, G. H.; Purcell, W. R.; Leising, M. D.; Harris, M. J.

    1997-01-01

    Observations from the oriented scintillation spectrometer experiment of the gamma ray lines originating from a variety of Galactic center sources are reviewed. Extensive observations were acquired of the Galactic center region, including the 0.511 MeV positron annihilation line and associated positronium continuum and Al-26 emission. The results reviewed include: Co-57 from SN 1987A; limits on Co-56 from SN 1991T; gamma ray lines from solar flares; searches for Ti-44 emission from Cas A, and searches for C-12 and O-16 lines from the Orion region.

  18. Gamma ray line observations with OSSE

    NASA Technical Reports Server (NTRS)

    Kurfess, J. D.; Grove, J. E.; Johnson, W. N.; Murphy, R. J.; Share, G. H.; Purcell, W. R.; Leising, M. D.; Harris, M. J.

    1997-01-01

    Observations from the oriented scintillation spectrometer experiment of the gamma ray lines originating from a variety of Galactic center sources are reviewed. Extensive observations were acquired of the Galactic center region, including the 0.511 MeV positron annihilation line and associated positronium continuum and Al-26 emission. The results reviewed include: Co-57 from SN 1987A; limits on Co-56 from SN 1991T; gamma ray lines from solar flares; searches for Ti-44 emission from Cas A, and searches for C-12 and O-16 lines from the Orion region.

  19. VHE Gamma-ray Supernova Remnants

    SciTech Connect

    Funk, Stefan; /KIPAC, Menlo Park

    2007-01-22

    Increasing observational evidence gathered especially in X-rays and {gamma}-rays during the course of the last few years support the notion that Supernova remnants (SNRs) are Galactic particle accelerators up to energies close to the ''knee'' in the energy spectrum of Cosmic rays. This review summarizes the current status of {gamma}-ray observations of SNRs. Shell-type as well as plerionic type SNRs are addressed and prospect for observations of these two source classes with the upcoming GLAST satellite in the energy regime above 100 MeV are given.

  20. Radioactivities and gamma-rays from supernovae

    NASA Technical Reports Server (NTRS)

    Woosley, S. E.

    1991-01-01

    An account is given of the implications of several calculations relevant to the estimation of gamma-ray signals from various explosive astronomical phenomena. After discussing efforts to constrain the amounts of Ni-57 and Ti-44 produced in SN 1987A, attention is given to the production of Al-27 in massive stars and SNs. A 'delayed detonation' model of type Ia SNs is proposed, and the gamma-ray signal which may be expected when a bare white dwarf collapses directly into a neutron star is discussed.

  1. Gamma ray spectrometer for Lunar Scout 2

    NASA Technical Reports Server (NTRS)

    Moss, C. E.; Burt, W. W.; Edwards, B. C.; Martin, R. A.; Nakano, George H.; Reedy, R. C.

    1993-01-01

    We review the current status of the Los Alamos program to develop a high-resolution gamma-ray spectrometer for the Lunar Scout-II mission, which is the second of two Space Exploration Initiative robotic precursor missions to study the Moon. This instrument will measure gamma rays in the energy range of approximately 0.1 - 10 MeV to determine the composition of the lunar surface. The instrument is a high-purity germanium crystal surrounded by an CsI anticoincidence shield and cooled by a split Stirling cycle cryocooler. It will provide the abundance of many elements over the entire lunar surface.

  2. Nuclear Forensics using Gamma-ray Spectroscopy

    NASA Astrophysics Data System (ADS)

    Norman, E. B.

    2016-09-01

    Much of George Dracoulis's research career was devoted to utilising gamma-ray spectroscopy in fundamental studies in nuclear physics. This same technology is useful in a wide range of applications in the area of nuclear forensics. Over the last several years, our research group has made use of both high- and low-resolution gamma-ray spectrometers to: identify the first sample of plutonium large enough to be weighed; determine the yield of the Trinity nuclear explosion; measure fission fragment yields as a function of target nucleus and neutron energy; and observe fallout in the U. S. from the Fukushima nuclear reactor accident.

  3. The gamma-ray laser project

    NASA Astrophysics Data System (ADS)

    Collins, Carl B.

    1987-07-01

    Recent approaches to the problem of the gamma-ray laser have focused on upconversion techniques in which metastable nuclei are pumped with long wavelength radiation. At the nuclear level the storage of energy can approach tera-Joules (10 to the 12th power J) per liter for thousands of years. However, any plan to use such a resource for a gamma-ray laser poses problems of a broad interdisciplinary nature requiring the fusion of concepts taken from relatively unrelated fields of physics.

  4. Gamma ray spectroscopy monitoring method and apparatus

    DOEpatents

    Stagg, William R; Policke, Timothy A

    2017-05-16

    The present invention relates generally to the field of gamma ray spectroscopy monitoring and a system for accomplishing same to monitor one or more aspects of various isotope production processes. In one embodiment, the present invention relates to a monitoring system, and method of utilizing same, for monitoring one or more aspects of an isotope production process where the monitoring system comprises: (A) at least one sample cell; (B) at least one measuring port; (C) at least one adjustable collimator device; (D) at least one shutter; and (E) at least one high resolution gamma ray spectrometer.

  5. Gamma ray astronomy and black hole astrophysics

    NASA Technical Reports Server (NTRS)

    Liang, Edison P.

    1990-01-01

    The study of soft gamma emissions from black-hole candidates is identified as an important element in understanding black-hole phenomena ranging from stellar-mass black holes to AGNs. The spectra of Cyg X-1 and observations of the Galactic Center are emphasized, since thermal origins and MeV gamma-ray bumps are evident and suggest a thermal-pair cloud picture. MeV gamma-ray observations are suggested for studying black hole astrophysics such as the theorized escaping pair wind, the anticorrelation between the MeV gamma bump and the soft continuum, and the relationship between source compactness and temperature.

  6. Inhibition of gamma-ray dose-rate effects by D/sup 2/O and inhibitors of poly(ADP-ribose) synthetase in cultured mammalian L5178Y cells

    SciTech Connect

    Ueno, A.M.; Tanaka, O.; Matsudaira, H.

    1984-06-01

    Effects of deuterium oxide (D/sub 2/O) and 3-aminobenzamide, an inhibitor of poly(ADP-ribose) synthetase, on cell proliferation and survival were studied in cultured mammalian L5178Y cells under growing conditions and after acute and low-dose-rate irradiation at about 0.1 to 0.4 Gy/hr of ..gamma.. rays. Growth of irradiated and unirradiated cells was inhibited by 45% D/sub 2/O but not by 3-aminobenzamide at 10mM, except for treatments longer than 30 hr. The presence of these agents either alone or in combination during irradiation at low dose rates suppressed almost totally the decrease in cell killing due to the decrease in dose rate. Among other inhibitors tested, theobromine and theophylline were found to be effective in eliminating the dose-rate effects of ..gamma.. rays. Possible mechanisms underlying the inhibition are discussed.

  7. Found: A Galaxy's Missing Gamma Rays

    NASA Astrophysics Data System (ADS)

    Kohler, Susanna

    2016-04-01

    Recent reanalysis of data from the Fermi Gamma-ray Space Telescope has resulted in the first detection of high-energy gamma rays emitted from a nearby galaxy. This discovery reveals more about how supernovae interact with their environments.Colliding Supernova RemnantAfter a stellar explosion, the supernovas ejecta expand, eventually encountering the ambient interstellar medium. According to models, this generates a strong shock, and a fraction of the kinetic energy of the ejecta is transferred into cosmic rays high-energy radiation composed primarily of protons and atomic nuclei. Much is still unknown about this process, however. One open question is: what fraction of the supernovas explosion power goes into accelerating these cosmic rays?In theory, one way to answer this is by looking for gamma rays. In a starburst galaxy, the collision of the supernova-accelerated cosmic rays with the dense interstellar medium is predicted to produce high-energy gamma rays. That radiation should then escape the galaxy and be visible to us.Pass 8 to the RescueObservational tests of this model, however, have beenstumped by Arp 220. This nearby ultraluminous infrared galaxy is the product of a galaxy merger ~700 million years ago that fueled a frenzy of starbirth. Due to its dusty interior and extreme levels of star formation, Arp 220 has long been predicted to emit the gamma rays produced by supernova-accelerated cosmic rays. But though weve looked, gamma-ray emission has never been detected from this galaxy until now.In a recent study, a team of scientists led by Fang-Kun Peng (Nanjing University) reprocessed 7.5 years of Fermi observations using the new Pass 8 analysis software. The resulting increase in resolution revealed the first detection of GeV emission from Arp 220!Acceleration EfficiencyGamma-ray luminosity vs. total infrared luminosity for LAT-detected star-forming galaxies and Seyferts. Arp 220s luminosities are consistent with the scaling relation. [Peng et al. 2016

  8. Differential expression of thymic DNA repair genes in low-dose-rate irradiated AKR/J mice

    PubMed Central

    Bong, Jin Jong; Kang, Yu Mi; Shin, Suk Chul; Choi, Seung Jin

    2013-01-01

    We previously determined that AKR/J mice housed in a low-dose-rate (LDR) (137Cs, 0.7 mGy/h, 2.1 Gy) γ-irradiation facility developed less spontaneous thymic lymphoma and survived longer than those receiving sham or high-dose-rate (HDR) (137Cs, 0.8 Gy/min, 4.5 Gy) radiation. Interestingly, histopathological analysis showed a mild lymphomagenesis in the thymus of LDR-irradiated mice. Therefore, in this study, we investigated whether LDR irradiation could trigger the expression of thymic genes involved in the DNA repair process of AKR/J mice. The enrichment analysis of Gene Ontology terms and Kyoto Encyclopedia of Genes and Genomes pathways showed immune response, nucleosome organization, and the peroxisome proliferator-activated receptors signaling pathway in LDR-irradiated mice. Our microarray analysis and quantitative polymerase chain reaction data demonstrated that mRNA levels of Lig4 and RRM2 were specifically elevated in AKR/J mice at 130 days after the start of LDR irradiation. Furthermore, transcriptional levels of H2AX and ATM, proteins known to recruit DNA repair factors, were also shown to be upregulated. These data suggest that LDR irradiation could trigger specific induction of DNA repair-associated genes in an attempt to repair damaged DNA during tumor progression, which in turn contributed to the decreased incidence of lymphoma and increased survival. Overall, we identified specific DNA repair genes in LDR-irradiated AKR/J mice. PMID:23820165

  9. [Side effects of postoperative irradiation of uterine cancer with high dose rate iridium and low dose rate radium].

    PubMed

    Kucera, H; Unel, N; Weghaupt, K

    1986-02-01

    A report is given about reversible and irreversible complications following postoperative irradiation in cases of endometrial carcinoma. Intravaginal brachytherapy was performed. In advanced cases or in cases with poor prognosis (tumor grading) percutaneous irradiation was added (Co60). In 156 cases low-dose-rate irradiation (Ra226) and in 143 cases high-dose-rate irradiation (Ir192) was applied intravaginally. Reversible complications (cystitis, proctitis) could be observed following Radium in 7%, following Iridium in 14%. Irreversible complications (fistulas, stenoses): 1.9% following Radium and 3.5% following Iridium. When high-dose-rate irradiation was combined with percutaneous Co60 therapy, reversible complications occurred in 22.8%. After changing the Iridium-therapy scheme (reduction of dose from 10 to 7 Gy and irradiation only of the upper two thirds of the vagina) complications only could be observed in the same level as in Radium-therapy. High-dose-rate irradiation does not need hospitalization of the patients.

  10. Optimization strategies for pulsed low-dose-rate IMRT of recurrent lung and head and neck cancers.

    PubMed

    Kang, Shengwei; Lang, Jinyi; Wang, Pei; Li, Jie; Lin, Muhan; Chen, Xiaoming; Guo, Ming; Chen, Fu; Chen, Lili; Ma, Charlie Ming

    2014-05-08

    Pulsed low-dose-rate radiotherapy (PLDR) has been proven to be a valid method of reirradiation. Previous studies of recurrent cancer radiotherapy were mainly based on conventional 3D CRT and VMAT delivery techniques. There are difficulties in IMRT planning using existing commercial treatment planning systems (TPS) to meet the PLDR protocol. This work focuses on PLDR using ten-field IMRT and a commercial TPS for two specific sites: recurrent lung cancers and head and neck cancers. Our PLDR protocol requires that the maximum dose to the PTV be less than 0.4 Gy and the mean dose to be 0.2 Gy per field. We investigated various planning strategies to meet the PLDR requirements for 20 lung and head and neck patients. The PTV volume for lung cases ranged from 101.7 to 919.4 cm3 and the maximum dose to the PTV ranged from 0.22 to 0.39 Gy. The PTV volume for head and neck cases ranged from 66.2 to 282.1 cm3 and the maximum dose to the PTV ranged from 0.21 to 0.39 Gy. With special beam arrangements and dosimetry parameters, it is feasible to use a commercial TPS to generate quality PLDR IMRT plans for lung and head and neck reirradiation.

  11. Low-dose rate brachytherapy for patients with low- or intermediate-risk prostate cancer: A systematic review.

    PubMed

    Rodrigues, George; Yao, Xiaomei; Loblaw, D Andrew; Brundage, Michael; Chin, Joseph L

    2013-11-01

    We review the current evidence for the role of low-dose rate brachytherapy (PB) in patients with low- or intermediate-risk prostate cancer using a systematic review of the literature. We searched MEDLINE and EMBASE (from January 1996 to October 2011), the Cochrane Library, relevant guideline web-sites, and websites for meetings specific for genitourinary diseases. Ten systematic reviews and 55 single-study papers met the pre-planned study selection criteria. In the end, 36 articles were abstracted and analyzed for this systematic review. There is no evidence for a difference in efficacy between PB and external beam radiation therapy (EBRT), or between PB and radical prostatectomy (RP). During the 6 months to 3 years after treatment, PB was associated with less urinary incontinence and sexual impotency than RP, and RP was associated with less urinary irritation and rectal morbidity than PB. However, these differences diminished over time. PB conferred less risk of impotency and rectal morbidity in the three years after treatment than EBRT. Iodine-125 and alladium-103 did not differ with respect to biochemical relapse-free survival and patient-reported outcomes. PB alone is a treatment option with equal efficacy to EBRT or RP alone in patients with newly diagnosed low- or intermediate-risk prostate cancer who require or choose active treatment.

  12. Low-dose-rate brachytherapy for patients with transurethral resection before implantation in prostate cancer. Long-term results

    PubMed Central

    Prada, Pedro J.; Anchuelo, Javier; Blanco, Ana García; Payá, Gema; Cardenal, Juan; Acuña, Enrique; Ferri, María; Vázquez, Andrés; Pacheco, Maite; Sanchez, Jesica

    2016-01-01

    ABSTRACT Objectives We analyzed the long-term oncologic outcome for patients with prostate cancer and transurethral resection who were treated using low-dose-rate (LDR) prostate brachytherapy. Methods and Materials From January 2001 to December 2005, 57 consecutive patients were treated with clinically localized prostate cancer. No patients received external beam radiation. All of them underwent LDR prostate brachytherapy. Biochemical failure was defined according to the “Phoenix consensus”. Patients were stratified as low and intermediate risk based on The Memorial Sloan Kettering group definition. Results The median follow-up time for these 57 patients was 104 months. The overall survival according to Kaplan-Meier estimates was 88% (±6%) at 5 years and 77% (±6%) at 12 years. The 5 and 10 years for failure in tumour-free survival (TFS) was 96% and respectively (±2%), whereas for biochemical control was 94% and respectively (±3%) at 5 and 10 years, 98% (±1%) of patients being free of local recurrence. A patient reported incontinence after treatment (1.7%). The chronic genitourinary complains grade I were 7% and grade II, 10%. At six months 94% of patients reported no change in bowel function. Conclusions The excellent long-term results and low morbidity presented, as well as the many advantages of prostate brachytherapy over other treatments, demonstrates that brachytherapy is an effective treatment for patients with transurethral resection and clinical organ-confined prostate cancer. PMID:27136466

  13. Radiation design and control features of a hospital room for a low dose rate remote afterloading unit

    SciTech Connect

    Glasgow, G.P.; Corrigan, K.W.

    1995-09-01

    We have renovated, and used for four years, a small 3.4 m x 4.3 m conventional patient second floor hospital room to accommodate a low dose rate remote afterloading unit containing 13 GBq (0.35 Ci) of {sup 137}Cs. Supplemental room shielding consists of a power assisted door (536 kg, 1.7 cm thickness of lead), 1.3 cm lead wall shielding at selected wall locations and on a projector shield beneath the bed, and 0.6 cm of lead over the floor above. Radiation control features consisted of a room interior radiation detector independent of the remote afterloading unit, a redundant patient/nurse communication system, a remote control system, a door interlock system to insert and retract the radioactive pellets, and a visible and audible status indictator system located at a nearby nurses` work station. Renovation costs (in 1990 dollars) were $383 per square foot; total project costs were $187,000. Nursing personnel radiation exposure was reduced from about 6 {mu}Sv (mg Ra eq){sup -1} (0.6 mrem (mg Ra eq){sup -1}) to about 0.7 {mu}Sv (mg Ra eq){sup -1} (0.07 mrem (mg Ra eq){sup -1}), almost a tenfold reduction. 6 refs., 2 figs., 1 tab.

  14. Study of acute WCo, low dose rate CF-252 and CS-137 radiation on LSA ascites lymphoma in vivo

    SciTech Connect

    Maruyama, Y.; Feola, J.M.; Magura, C.; Onomura, C.I.; Beach, J.L.

    1985-11-01

    Dose response curves were determined for the LSA lymphoma for acute WCo, low dose rate Cs-137 and Cf-252 radiations using in vivo survival time bioassay. Mean survival times increased with dose with a prominent oxygen effect noted for acute WCo and Cs-137. OER was lowest for Cf-252 where it was approximately 1.4. The RBEn for oxic LSA cells to Cf-252 neutrons was 3.1 for acute WCo and 4.2 for Cs-137. It was larger for hypoxic tumor and RBE was 5.3 for WCo and 5.8 for Cs-137. Survival curves based on survival data used a multitarget dose-response model for photon radiation and exponential dose-response for Cf-252 radiation. When LSA was irradiated in advanced tumor stages in vivo, Cf-252 was much more effective than acute WCo or LDR Cs-137 for increasing survival time. Tumor response in vivo matched the in vitro irradiated tumor data. No schedule dependence was observed for mixing of WCo and Cf-252 radiations.

  15. Enhanced low dose rate sensitivity (ELDRS) in a voltage comparator which only utilizes complementary vertical NPN and PNP transistors

    SciTech Connect

    Krieg, J.F.; Titus, J.L.; Emily, D.; Gehlhausen, M.; Swonger, J.; Platteter, D.

    1999-12-01

    For the first time, enhanced low dose rate sensitivity (ELDRS) is reported in a vertical bipolar process. A radiation hardness assurance (RHA) test method was successfully demonstrated on a linear circuit, the HS139RH quad comparator, and its discrete transistor elements. This circuit only uses vertical NPN and PNP transistors. Radiation tests on the HS139RH were performed at 25 C using dose rates of 50 rd(Si)/s, 100 mrd(Si)/s and 10 mrd(Si)/s, and at 100 C using a dose rate of 10 rd(Si)/s. Tests at dose rates of 50 rd(Si)/s at 25 C and 10 rd(Si)/s at 100 C were performed on discrete vertical NPN and PNP transistor elements which comprise the HS139RH. Transistor and circuit responses were evaluated. The die's passivation overcoat layers were varied to examine the effect of removing a nitride layer and thinning a deposited SiO{sup 2} (silox) layer.

  16. The effect of low dose rate irradiation on the swelling of 12% cold-worked 316 stainless steel.

    SciTech Connect

    Allen, T. R.

    1999-03-02

    In pressurized water reactors (PWRs), stainless steel components are irradiated at temperatures that may reach 400 C due to gamma heating. If large amounts of swelling (>10%) occur in these reactor internals, significant swelling related embrittlement may occur. Although fast reactor studies indicate that swelling should be insignificant at PWR temperatures, the low dose rate conditions experienced by PWR components may possibly lead to significant swelling. To address these issues, JNC and ANL have collaborated to analyze swelling in 316 stainless steel, irradiated in the EBR-II reactor at temperatures from 376-444 C, at dose rates between 4.9 x 10{sup {minus}8} and 5.8 x 10{sup {minus}7} dpa/s, and to doses of 56 dpa. For these irradiation conditions, the swelling decreases markedly at temperatures less than approximately 386 C, with the extrapolated swelling at 100 dpa being around 3%. For temperatures greater than 386 C, the swelling extrapolated to 100 dpa is around 9%. For a factor of two difference in dose rate, no statistically significant effect of dose rate on swelling was seen. For the range of dose rates analyzed, the swelling measurements do not support significant (>10%) swelling of 316 stainless steel in PWRs.

  17. Relativistic feedback models of terrestrial gamma-ray flashes and gamma-ray glows

    NASA Astrophysics Data System (ADS)

    Dwyer, J. R.

    2015-12-01

    Relativistic feedback discharges, also known as dark lightning, are capable of explaining many of the observed properties of terrestrial gamma-ray flashes (TGFs) and gamma-ray glows, both created within thunderstorms. During relativistic feedback discharges, the generation of energetic electrons is self-sustained via the production of backward propagating positrons and back-scattered x-rays, resulting in very larges fluxes of energetic radiation. In addition, ionization produces large electric currents that generate LF/VLF radio emissions and eventually discharge the electric field, terminating the gamma-ray production. In this presentation, new relativistic feedback model results will be presented and compared to recent observations.

  18. Heterogeneity in Short Gamma-Ray Bursts

    NASA Technical Reports Server (NTRS)

    Norris, Jay P.; Gehrels Neil; Scargle, Jeffrey D.

    2011-01-01

    We analyze the Swift/BAT sample of short gamma-ray bursts, using an objective Bayesian Block procedure to extract temporal descriptors of the bursts' initial pulse complexes (IPCs). The sample comprises 12 and 41 bursts with and without extended emission (EE) components, respectively. IPCs of non-EE bursts are dominated by single pulse structures, while EE bursts tend to have two or more pulse structures. The medians of characteristic timescales - durations, pulse structure widths, and peak intervals - for EE bursts are factors of approx 2-3 longer than for non-EE bursts. A trend previously reported by Hakkila and colleagues unifying long and short bursts - the anti-correlation of pulse intensity and width - continues in the two short burst groups, with non-EE bursts extending to more intense, narrower pulses. In addition we find that preceding and succeeding pulse intensities are anti-correlated with pulse interval. We also examine the short burst X-ray afterglows as observed by the Swift/XRT. The median flux of the initial XRT detections for EE bursts (approx 6 X 10(exp -10) erg / sq cm/ s) is approx > 20 x brighter than for non-EE bursts, and the median X-ray afterglow duration for EE bursts (approx 60,000 s) is approx 30 x longer than for non-EE bursts. The tendency for EE bursts toward longer prompt-emission timescales and higher initial X-ray afterglow fluxes implies larger energy injections powering the afterglows. The longer-lasting X-ray afterglows of EE bursts may suggest that a significant fraction explode into more dense environments than non-EE bursts, or that the sometimes-dominant EE component efficiently p()wers the afterglow. Combined, these results favor different progenitors for EE and non-EE short bursts.

  19. HETEROGENEITY IN SHORT GAMMA-RAY BURSTS

    SciTech Connect

    Norris, Jay P.; Gehrels, Neil

    2011-07-01

    We analyze the Swift/BAT sample of short gamma-ray bursts, using an objective Bayesian Block procedure to extract temporal descriptors of the bursts' initial pulse complexes (IPCs). The sample is comprised of 12 and 41 bursts with and without extended emission (EE) components, respectively. IPCs of non-EE bursts are dominated by single pulse structures, while EE bursts tend to have two or more pulse structures. The medians of characteristic timescales-durations, pulse structure widths, and peak intervals-for EE bursts are factors of {approx}2-3 longer than for non-EE bursts. A trend previously reported by Hakkila and colleagues unifying long and short bursts-the anti-correlation of pulse intensity and width-continues in the two short burst groups, with non-EE bursts extending to more intense, narrower pulses. In addition, we find that preceding and succeeding pulse intensities are anti-correlated with pulse interval. We also examine the short burst X-ray afterglows as observed by the Swift/X-Ray Telescope (XRT). The median flux of the initial XRT detections for EE bursts ({approx}6x10{sup -10} erg cm{sup -2} s{sup -1}) is {approx}>20x brighter than for non-EE bursts, and the median X-ray afterglow duration for EE bursts ({approx}60,000 s) is {approx}30x longer than for non-EE bursts. The tendency for EE bursts toward longer prompt-emission timescales and higher initial X-ray afterglow fluxes implies larger energy injections powering the afterglows. The longer-lasting X-ray afterglows of EE bursts may suggest that a significant fraction explode into denser environments than non-EE bursts, or that the sometimes-dominant EE component efficiently powers the afterglow. Combined, these results favor different progenitors for EE and non-EE short bursts.

  20. A simple gamma ray direction finder.

    PubMed

    Fujimoto, K

    2006-07-01

    One of the simplest gamma spectrometry systems that could provide the directional information of incident gamma rays has been developed. The system consists of a 3'' x 3'' phi NaI (Tl) scintillator, a specially shaped lead shield, and software. The measurement was carried out four times by rotating the shield position along the axis of the detector to obtain four energy spectra at one location. Four count rates at a special region of interest in the spectra were fed into the software for determining incident directions of gamma rays. Experiments using (137)Cs and (54)Mn at the same time demonstrated that the direction of gamma rays from several dominant sources from any direction could be identified with good precision by the total measurement time of 10 to 20 min. The system could be used to identify the locations of missing radioactive sources or the cause of elevation in ambient radiation dose rates. The disadvantages of the present system are follows: (1) It requires four time measurements at one location; (2) It can provide one pseudo incident angle when several contamination sources exist around the detector system and emit the same energy gamma rays; and (3) It can scan only one plane geometry that is usually chosen as the horizontal plane.

  1. Gamma-ray Astrophysics with AGILE

    SciTech Connect

    Longo, Francesco |; Tavani, M.; Barbiellini, G.; Argan, A.; Basset, M.; Boffelli, F.; Bulgarelli, A.; Caraveo, P.; Cattaneo, P.; Chen, A.; Costa, E.; Del Monte, E.; Di Cocco, G.; Di Persio, G.; Donnarumma, I.; Feroci, M.; Fiorini, M.; Foggetta, L.; Froysland, T.; Frutti, M.

    2007-07-12

    AGILE will explore the gamma-ray Universe with a very innovative instrument combining for the first time a gamma-ray imager and a hard X-ray imager. AGILE will be operational in spring 2007 and it will provide crucial data for the study of Active Galactic Nuclei, Gamma-Ray Bursts, unidentified gamma-ray sources. Galactic compact objects, supernova remnants, TeV sources, and fundamental physics by microsecond timing. The AGILE instrument is designed to simultaneously detect and image photons in the 30 MeV - 50 GeV and 15 - 45 keV energy bands with excellent imaging and timing capabilities, and a large field of view covering {approx} 1/5 of the entire sky at energies above 30 MeV. A CsI calorimeter is capable of GRB triggering in the energy band 0.3-50 MeV AGILE is now (March 2007) undergoing launcher integration and testing. The PLSV launch is planned in spring 2007. AGILE is then foreseen to be fully operational during the summer of 2007.

  2. Gamma-Ray Telescope and Uncertainty Principle

    ERIC Educational Resources Information Center

    Shivalingaswamy, T.; Kagali, B. A.

    2012-01-01

    Heisenberg's Uncertainty Principle is one of the important basic principles of quantum mechanics. In most of the books on quantum mechanics, this uncertainty principle is generally illustrated with the help of a gamma ray microscope, wherein neither the image formation criterion nor the lens properties are taken into account. Thus a better…

  3. New shield for gamma-ray spectrometry

    NASA Technical Reports Server (NTRS)

    Brar, S. S.; Gustafson, P. F.; Nelson, D. M.

    1969-01-01

    Gamma-ray shield that can be evacuated, refilled with a clean gas, and pressurized for exclusion of airborne radioactive contaminants effectively lowers background noise. Under working conditions, repeated evacuation and filling procedures have not adversely affected the sensitivity and resolution of the crystal detector.

  4. HAWC observatory catches first gamma rays

    NASA Astrophysics Data System (ADS)

    Frías Villegas, Gabriela

    2013-06-01

    The world's largest and most modern gamma-ray observatory has carried out its first successful observations. Located inside the Pico de Orizaba national park in the Mexican state of Puebla, the High-Altitude Water Cherenkov Observatory (HAWC) is a collaboration between 26 Mexican and US institutions.

  5. Cascade model of gamma-ray bursts

    NASA Technical Reports Server (NTRS)

    Sturrock, P. A.; Harding, A. K.; Daugherty, J. K.

    1989-01-01

    If, in a neutron star magnetosphere, an electron is accelerated to an energy of 10 to the 11th or 12th power eV by an electric field parallel to the magnetic field, motion of the electron along the curved field line leads to a cascade of gamma rays and electron-positron pairs. This process is believed to occur in radio pulsars and gamma ray burst sources. Results are presented from numerical simulations of the radiation and photon annihilation pair production processes, using a computer code previously developed for the study of radio pulsars. A range of values of initial energy of a primary electron was considered along with initial injection position, and magnetic dipole moment of the neutron star. The resulting spectra was found to exhibit complex forms that are typically power law over a substantial range of photon energy, and typically include a dip in the spectrum near the electron gyro-frequency at the injection point. The results of a number of models are compared with data for the 5 Mar., 1979 gamma ray burst. A good fit was found to the gamma ray part of the spectrum, including the equivalent width of the annihilation line.

  6. INTEGRAL: International Gamma Ray Astrophysics Laboratory

    NASA Astrophysics Data System (ADS)

    Winkler, Christoph

    1992-07-01

    INTEGRAL is dedicated to the fine spectroscopy and imaging of celestial gamma ray sources in the energy range 15 keV to 10 MeV. The instruments on INTEGRAL will achieve a gamma ray line sensitivity of 3 times 10 to the minus 6th power ph/sq cm/s, a continuum sensitivity of 3 times 10 to the minus 8th power ph/sq cm/s/keV at 1 MeV (approximately 10 mCrab at 1 MeV) and imaging with an angular resolution of better than 20 minutes. This represents an order of magnitude improvement over the Gamma Ray Observatory (GRO) in line sensitivity, energy resolution and angular resolution. Comparison with the low energy gamma ray telescope Sigma also shows a major advance: the continuum sensitivity improvement is considerably more than one order of magnitude between 100 keV and 1 MeV; and the narrow line sensitivity is increased by nearly two orders of magnitude. INTEGRAL consists of two main instruments: a germanium spectrometer and a caesium iodide coded aperture mask imager. These instruments are supplemented by two monitors: an X-ray monitor and an optical transient camera.

  7. Study of gamma-ray strength functions

    SciTech Connect

    Gardner, D.G.; Gardner, M.A.; Dietrich, F.S.

    1980-08-07

    The use of gamma-ray strength function systematics to calculate neutron capture cross sections and capture gamma-ray spectra is discussed. The ratio of the average capture width, GAMMA/sub ..gamma../-bar, to the average level spacing, D/sub obs/, both at the neutron separation energy, can be derived from such systematics with much less uncertainty than from separate systematics for values of GAMMA/sub ..gamma../-bar and D/sub obs/. In particular, the E1 gamma-ray strength function is defined in terms of the giant dipole resonance (GDR). The GDR line shape is modeled with the usual Lorentzian function and also with a new energy-dependent, Breit-Wigner (EDBW) function. This latter form is further parameterized in terms of two overlapping resonances, even for nuclei where photonuclear measurements do not resolve two peaks. In the mass ranges studied, such modeling is successful for all nuclei away from the N = 50 closed neutron shell. Near the N = 50 shell, a one-peak EDBW appears to be more appropriate. Examples of calculated neutron capture excitation functions and capture gamma-ray spectra using the EDBW form are given for target nuclei in the mass-90 region and also in the Ta-Au mass region. 20 figures.

  8. Gamma ray observations of the solar system

    SciTech Connect

    Not Available

    1981-01-01

    Two general categories are discussed concerning the evolution of the solar system: the dualistic view, the planetesimal approach and the monistic view, the nebular hypothesis. The major points of each view are given and the models that are developed from these views are described. Possible applications of gamma ray astronomical observations to the question of the dynamic evolution of the solar system are discussed.

  9. Gamma-ray Emission from Globular Clusters

    NASA Astrophysics Data System (ADS)

    Tam, Pak-Hin T.; Hui, Chung Y.; Kong, Albert K. H.

    2016-03-01

    Over the last few years, the data obtained using the Large Area Telescope (LAT) aboard the Fermi Gamma-ray Space Telescope has provided new insights on high-energy processes in globular clusters, particularly those involving compact objects such as MilliSecond Pulsars (MSPs). Gamma-ray emission in the 100 MeV to 10 GeV range has been detected from more than a dozen globular clusters in our galaxy, including 47 Tucanae and Terzan 5. Based on a sample of known gammaray globular clusters, the empirical relations between gamma-ray luminosity and properties of globular clusters such as their stellar encounter rate, metallicity, and possible optical and infrared photon energy densities, have been derived. The measured gamma-ray spectra are generally described by a power law with a cut-off at a few gigaelectronvolts. Together with the detection of pulsed γ-rays from two MSPs in two different globular clusters, such spectral signature lends support to the hypothesis that γ-rays from globular clusters represent collective curvature emission from magnetospheres of MSPs in the clusters. Alternative models, involving Inverse-Compton (IC) emission of relativistic electrons that are accelerated close to MSPs or pulsar wind nebula shocks, have also been suggested. Observations at >100 GeV by using Fermi/LAT and atmospheric Cherenkov telescopes such as H.E.S.S.-II, MAGIC-II, VERITAS, and CTA will help to settle some questions unanswered by current data.

  10. Gamma ray observations of the solar system

    NASA Technical Reports Server (NTRS)

    1981-01-01

    Two general categories are discussed concerning the evolution of the solar system: the dualistic view, the planetesimal approach; and the monistic view, the nebular hypothesis. The major points of each view are given and the models that are developed from these views are described. Possible applications of gamma ray astronomical observations to the question of the dynamic evolution of the solar system are discussed.

  11. Diffuse Galactic Soft Gamma-Ray Emission

    NASA Astrophysics Data System (ADS)

    Boggs, S. E.; Lin, R. P.; Slassi-Sennou, S.; Coburn, W.; Pelling, R. M.

    2000-11-01

    The Galactic diffuse soft gamma-ray (30-800 keV) emission has been measured from the Galactic center by the High Resolution Gamma-Ray and Hard X-Ray Spectrometer balloon-borne germanium instrument to determine the spectral characteristics and origin of the emission. The resulting Galactic diffuse continuum is found to agree well with a single power law (plus positronium) over the entire energy range, consistent with RXTE and COMPTEL/Compton Gamma Ray Observatory observations at lower and higher energies, respectively. We find no evidence of spectral steepening below 200 keV, as has been reported in previous observations. The spatial distribution along the Galactic ridge is found to be nearly flat, with upper limits set on the longitudinal gradient and with no evidence of an edge in the observed region. The soft gamma-ray diffuse spectrum is well modeled by inverse Compton scattering of interstellar radiation off of cosmic-ray electrons, minimizing the need to invoke inefficient nonthermal bremsstrahlung emission. The resulting power requirement is well within that provided by Galactic supernovae. We speculate that the measured spectrum provides the first direct constraints on the cosmic-ray electron spectrum below 300 MeV.

  12. Gamma-ray Pulsars: Models and Predictions

    NASA Technical Reports Server (NTRS)

    Harding Alice K.; White, Nicholas E. (Technical Monitor)

    2000-01-01

    Pulsed emission from gamma-ray pulsars originates inside the magnetosphere, from radiation by charged particles accelerated near the magnetic poles or in the outer gaps. In polar cap models, the high energy spectrum is cut off by magnetic pair production above an energy that is, dependent on the local magnetic field strength. While most young pulsars with surface fields in the range B = 10(exp 12) - 10(exp 13) G are expected to have high energy cutoffs around several GeV, the gamma-ray spectra of old pulsars having lower surface fields may extend to 50 GeV. Although the gamma-ray emission of older pulsars is weaker, detecting pulsed emission at high energies from nearby sources would be an important confirmation of polar cap models. Outer gap models predict more gradual high-energy turnovers of the primary curvature emission around 10 GeV, but also predict an inverse Compton component extending to TeV energies. Detection of pulsed TeV emission, which would not survive attenuation at the polar caps, is thus an important test of outer gap models. Next-generation gamma-ray telescopes sensitive to GeV-TeV emission will provide critical tests of pulsar acceleration and emission mechanisms.

  13. Physics issues of gamma ray burst emissions

    NASA Technical Reports Server (NTRS)

    Liang, Edison

    1987-01-01

    The critical physics issues in the interpretation of gamma-ray-burst spectra are reviewed. An attempt is made to define the emission-region parameter space satisfying the maximum number of observational and theoretical constraints. Also discussed are the physical mechanisms responsible for the bursts that are most consistent with the above parameter space.

  14. TEMPORAL CORRELATIONS BETWEEN OPTICAL AND GAMMA-RAY ACTIVITY IN BLAZARS

    SciTech Connect

    Cohen, Daniel P.; Romani, Roger W.; Filippenko, Alexei V.; Cenko, S. Bradley; Zheng, WeiKang; Li, Weidong

    2014-12-08

    For this research, we have been using the 0.76 m Katzman Automatic Imaging Telescope (KAIT) at Lick Observatory to optically monitor a sample of 157 blazars that are bright in gamma-rays being detected with high significance (≥10σ) in one year by the Large Area Telescope (LAT) on the Fermi Gamma-ray Space Telescope. We attempt to observe each source on a three-day cadence with KAIT, subject to weather and seasonal visibility. The gamma-ray coverage is essentially continuous. KAIT observations extend over much of the five-year Fermi mission for several objects, and most have >100 optical measurements spanning the last three years. These blazars (flat-spectrum radio quasars and BL Lac objects) exhibit a wide range of flaring behavior. Using the discrete correlation function (DCF), here we search for temporal relationships between optical and gamma-ray light curves in the 40 brightest sources in hopes of placing constraints on blazar acceleration and emission zones. We find strong optical-gamma-ray correlation in many of these sources at time delays of ~1 to ~10 days, ranging between –40 and +30 days. A stacked average DCF of the 40 sources verifies this correlation trend, with a peak above 99% significance indicating a characteristic time delay consistent with 0 days. These findings strongly support the widely accepted leptonic models of blazar emission. However, we also find examples of apparently uncorrelated flares (optical flares with no gamma-ray counterpart and gamma-ray flares with no optical counterpart) that challenge simple, one-zone models of blazar emission. Moreover, we find that flat-spectrum radio quasars tend to have gamma-rays leading the optical, while intermediate- and high-synchrotron peak blazars with the most significant peaks have smaller lags/leads. In conclusion, it is clear that long-term monitoring at high cadence is necessary to reveal the underlying physical correlation.

  15. TEMPORAL CORRELATIONS BETWEEN OPTICAL AND GAMMA-RAY ACTIVITY IN BLAZARS

    SciTech Connect

    Cohen, Daniel P.; Filippenko, Alexei V.; Zheng, WeiKang; Li, Weidong; Romani, Roger W.; Cenko, S. Bradley

    2014-12-20

    We have been using the 0.76 m Katzman Automatic Imaging Telescope (KAIT) at Lick Observatory to optically monitor a sample of 157 blazars that are bright in gamma-rays being detected with high significance (≥10σ) in one year by the Large Area Telescope (LAT) on the Fermi Gamma-ray Space Telescope. We attempt to observe each source on a three-day cadence with KAIT, subject to weather and seasonal visibility. The gamma-ray coverage is essentially continuous. KAIT observations extend over much of the five-year Fermi mission for several objects, and most have >100 optical measurements spanning the last three years. These blazars (flat-spectrum radio quasars and BL Lac objects) exhibit a wide range of flaring behavior. Using the discrete correlation function (DCF), here we search for temporal relationships between optical and gamma-ray light curves in the 40 brightest sources in hopes of placing constraints on blazar acceleration and emission zones. We find strong optical-gamma-ray correlation in many of these sources at time delays of ∼1 to ∼10 days, ranging between –40 and +30 days. A stacked average DCF of the 40 sources verifies this correlation trend, with a peak above 99% significance indicating a characteristic time delay consistent with 0 days. These findings strongly support the widely accepted leptonic models of blazar emission. However, we also find examples of apparently uncorrelated flares (optical flares with no gamma-ray counterpart and gamma-ray flares with no optical counterpart) that challenge simple, one-zone models of blazar emission. Moreover, we find that flat-spectrum radio quasars tend to have gamma-rays leading the optical, while intermediate- and high-synchrotron peak blazars with the most significant peaks have smaller lags/leads. It is clear that long-term monitoring at high cadence is necessary to reveal the underlying physical correlation.

  16. Monitoring performance of the cameras under the high dose-rate gamma ray environments.

    PubMed

    Cho, Jai Wan; Choi, Young Soo; Jeong, Kyung Min

    2014-05-01

    CCD/CMOS cameras, loaded on a robot system, are generally used as the eye of the robot and monitoring unit. A major problem that arises when dealing with images provided by CCD/CMOS cameras under severe accident situations of a nuclear power plant is the presence of speckles owing to the high dose-rate gamma irradiation fields. To use a CCD/CMOS camera as a monitoring unit in a high radiation area, the legibility of the camera image in such intense gamma-radiation fields should therefore be defined. In this paper, the authors describe the monitoring index as a figure of merit of the camera's legibleness under a high dose-rate gamma ray irradiation environment. From a low dose-rate (10 Gy h) to a high dose-rate (200 Gy h) level, the legible performances of the cameras owing to the speckles are evaluated. The numbers of speckles generated by gamma ray irradiation in the camera image are calculated by an image processing technique. The legibility of the sensor indicator (thermo/hygrometer) owing to the number of speckles is also presented.

  17. Fermi: The Gamma-Ray Large Area Space Telescope Mission Status

    NASA Technical Reports Server (NTRS)

    McEnery, Julie E

    2014-01-01

    Following its launch in June 2008, high-energy gamma-ray observations by the Fermi Gamma-ray Space Telescope have unveiled over 1000 new sources and opened an important and previously unexplored window on a wide variety of phenomena. These have included the discovery of a population of pulsars pulsing only in gamma rays; the detection of photons up to 10s of gigaelectronvolts from gamma-ray bursts, enhancing our understanding of the astrophysics of these powerful explosions; the detection of hundreds of active galaxies; a measurement of the high energy cosmic-ray electron spectrum which may imply the presence of nearby astrophysical particle accelerators; the determination of the diffuse gamma-ray emission with unprecedented accuracy and the constraints on phenomena such as super-symmetric dark-matter annihilations and exotic relics from the Big Bang. Continuous monitoring of the high-energy gamma-ray sky has uncovered numerous outbursts from active galaxies and the discovery of transient sources in our galaxy. In this talk I will describe the current status of the Fermi observatory and review the science highlights from Fermi.

  18. A Strange Supernova with a Gamma-Ray Burst

    NASA Astrophysics Data System (ADS)

    1998-10-01

    Important Observations with La Silla Telescopes Several articles appear today in the scientific journal Nature about the strange supernova SN 1998bw that exploded earlier this year in the spiral galaxy ESO184-G82 . These studies indicate that this event was linked to a Gamma-Ray Burst and may thus provide new insights into this elusive phenomenon. Important observations of SN 1998bw have been made with several astronomical telescopes at the ESO La Silla Observatory by some of the co-authors of the Nature articles [1]. The measurements at ESO will continue during the next years. The early observations On April 25, the BeppoSAX satellite detected a Gamma-Ray Burst from the direction of the constellation Telescopium, deep in the southern sky. Although there is now general consensus that they originate in very distant galaxies, the underlying physical causes of these events that release great amounts of energy within seconds are still puzzling astronomers. Immediately after reports about the April 25 Burst had been received, astronomers at La Silla took some images of the sky region where the gamma-rays were observed as a "Target of Opportunity" (ToO) programme. The aim was to check if the visual light of one of the objects in the field had perhaps brightened when compared to exposures made earlier. This would then provide a strong indication of the location of the Gamma-Ray Burst. The digital exposures were transferred to the Italian/Dutch group around BeppoSax that had requested these ToO observations. Astronomers of this group quickly noticed a new, comparatively bright star, right on the arm of a small spiral galaxy. This galaxy was first catalogued in the 1970's during the ESO/Uppsala Survey of the Southern Sky and received the designation ESO184-G82 . It is located at a distance of about 140 million light-years. SN 1998bw ESO PR Photo 39a/98 ESO PR Photo 39a/98 [Preview - JPEG: 800 x 963 pix - 592k] [High-Res - JPEG: 3000 x 3612 pix - 4.1Mb] ESO PR Photo 39b/98

  19. Gamma ray bursts of black hole universe

    NASA Astrophysics Data System (ADS)

    Zhang, T. X.

    2015-07-01

    Slightly modifying the standard big bang theory, Zhang recently developed a new cosmological model called black hole universe, which has only a single postulate but is consistent with Mach's principle, governed by Einstein's general theory of relativity, and able to explain existing observations of the universe. In the previous studies, we have explained the origin, structure, evolution, expansion, cosmic microwave background radiation, quasar, and acceleration of black hole universe, which grew from a star-like black hole with several solar masses through a supermassive black hole with billions of solar masses to the present state with hundred billion-trillions of solar masses by accreting ambient matter and merging with other black holes. This study investigates gamma ray bursts of black hole universe and provides an alternative explanation for the energy and spectrum measurements of gamma ray bursts according to the black hole universe model. The results indicate that gamma ray bursts can be understood as emissions of dynamic star-like black holes. A black hole, when it accretes its star or merges with another black hole, becomes dynamic. A dynamic black hole has a broken event horizon and thus cannot hold the inside hot (or high-frequency) blackbody radiation, which flows or leaks out and produces a GRB. A star when it collapses into its core black hole produces a long GRB and releases the gravitational potential energy of the star as gamma rays. A black hole that merges with another black hole produces a short GRB and releases a part of their blackbody radiation as gamma rays. The amount of energy obtained from the emissions of dynamic star-like black holes are consistent with the measurements of energy from GRBs. The GRB energy spectra derived from this new emission mechanism are also consistent with the measurements.

  20. Gamma ray lines from the Galactic Center and gamma ray transients

    NASA Technical Reports Server (NTRS)

    Ramaty, R.; Leiter, D.; Lingenfelter, R. E.

    1981-01-01

    The observations and interpretations of cosmic (nonsolar) gamma ray lines are discussed. The most prominent of these lines is the e(+)e(-) annihilation line which was observed from the Galactic Center and from several gamma ray transients. At the Galactic Center the e(+)e(-) pairs are probably produced by an accreting massive black hole (solar mass of approximately one million) and annihilate within the central light year to produce a line at almost exactly 0.511 MeV. In gamma ray transients the annihilation line is redshifted by factors consistent with neutron star surface redshifts. Other observed transient gamma ray lines appear to be due to cyclotron absorption in the strong magnetic fields of neutron stars, and nuclear deexcitations and neutron capture, which could also occur on or around these objects.

  1. Studying the High Energy Gamma Ray Sky with Gamma Ray Large Area Space Telescope (GLAST)

    NASA Technical Reports Server (NTRS)

    Kamae, T.; Ohsugi, T.; Thompson, D. J.; Watanabe, K.

    1998-01-01

    Building on the success of the Energetic Gamma Ray Experiment Telescope (EGRET) on the Compton Gamma Ray Observatory, the Gamma Ray Large Area Space Telescope (GLAST) will make a major step in the study of such subjects as blazars, gamma Ray bursts, the search for dark matter, supernova remnants, pulsars, diffuse radiation, and unidentified high energy sources. The instrument will be built on new and mature detector technologies such as silicon strip detectors, low-power low-noise LSI, and a multilevel data acquisition system. GLAST is in the research and development phase, and one full tower (of 25 total) is now being built in collaborating institutes. The prototype tower will be tested thoroughly at Stanford Linear Accelerator Center (SLAC) in the fall of 1999.

  2. Investigation of gamma rays from the galactic center

    NASA Technical Reports Server (NTRS)

    Helmken, H. F.

    1973-01-01

    Data from Argentine balloon flights made to investigate gamma ray emission from the galactic center are summarized. Data are also summarized from a Palestine, Texas balloon flight to measure gamma rays from NP 0532 and Crab Nebulae.

  3. Risk of solid cancer in low dose-rate radiation epidemiological studies and the dose-rate effectiveness factor.

    PubMed

    Shore, Roy; Walsh, Linda; Azizova, Tamara; Rühm, Werner

    2017-10-01

    Estimated radiation risks used for radiation protection purposes have been based primarily on the Life Span Study (LSS) of atomic bomb survivors who received brief exposures at high dose rates, many with high doses. Information is needed regarding radiation risks from low dose-rate (LDR) exposures to low linear-energy-transfer (low-LET) radiation. We conducted a meta-analysis of LDR epidemiologic studies that provide dose-response estimates of total solid cancer risk in adulthood in comparison to corresponding LSS risks, in order to estimate a dose rate effectiveness factor (DREF). We identified 22 LDR studies with dose-response risk estimates for solid cancer after minimizing information overlap. For each study, a parallel risk estimate was derived from the LSS risk model using matching values for sex, mean ages at first exposure and attained age, targeted cancer types, and accounting for type of dosimetric assessment. For each LDR study, a ratio of the excess relative risk per Gy (ERR Gy(-1)) to the matching LSS ERR risk estimate (LDR/LSS) was calculated, and a meta-analysis of the risk ratios was conducted. The reciprocal of the resultant risk ratio provided an estimate of the DREF. The meta-analysis showed a LDR/LSS risk ratio of 0.36 (95% confidence interval [CI] 0.14, 0.57) for the 19 studies of solid cancer mortality and 0.33 (95% CI 0.13, 0.54) when three cohorts with only incidence data also were added, implying a DREF with values around 3, but statistically compatible with 2. However, the analyses were highly dominated by the Mayak worker study. When the Mayak study was excluded the LDR/LSS risk ratios increased: 1.12 (95% CI 0.40, 1.84) for mortality and 0.54 (95% CI 0.09, 0.99) for mortality + incidence, implying a lower DREF in the range of 1-2. Meta-analyses that included only cohorts in which the mean dose was <100 mGy yielded a risk ratio of 1.06 (95% CI 0.30, 1.83) for solid cancer mortality and 0.58 (95% CI 0.10, 1.06) for mortality

  4. Gamma ray spectroscopy in astrophysics: Solar gamma ray astronomy on solar maximum mission. [experimental design

    NASA Technical Reports Server (NTRS)

    Forrest, D. J.

    1978-01-01

    The SMM gamma ray experiment and the important scientific capabilities of the instrument are discussed. The flare size detectable as a function of spectrum integration time was studied. A preliminary estimate indicates that a solar gamma ray line at 4.4 MeV one-fifth the intensity of that believed to have been emitted on 4 August 1972 can be detected in approximately 1000 sec with a confidence level of 99%.

  5. Periodical assessment of genitourinary and gastrointestinal toxicity in patients who underwent prostate low-dose-rate brachytherapy

    PubMed Central

    2013-01-01

    Background To compare the periodical incidence rates of genitourinary (GU) and gastrointestinal (GI) toxicity in patients who underwent prostate low-dose-rate brachytherapy between the monotherapy group (seed implantation alone) and the boost group (in combination with external beam radiation therapy (EBRT)). Methods A total of 218 patients with a median follow-up of 42.5 months were enrolled. The patients were divided into 2 groups by treatment modality, namely, the monotherapy group (155 patients) and the boost group (63 patients). The periodical incidence rates of GU and GI toxicity were separately evaluated and compared between the monotherapy group and the boost group using the National Cancer Institute - Common Terminology Criteria for Adverse Events, version 3.0. To elucidate an independent factor among clinical and postdosimetric parameters to predict grade 2 or higher GU and GI toxicity in the acute and late phases, univariate and multivariate logistic regression analyses were carried out. Results Of all patients, 78.0% showed acute GU toxicity, and 7.8% showed acute GI toxicity, while 63.8% showed late GU toxicity, and 21.1% showed late GI toxicity. The incidence rates of late GU and GI toxicity were significantly higher in the boost group. Multivariate analysis showed that the International Prostate Symptom Score (IPSS) before seed implantation was a significant parameter to predict acute GU toxicity, while there were no significant predictive parameters for acute GI toxicity. On the other hand, combination with EBRT was a significant predictive parameter for late GU toxicity, and rectal volume (mL) receiving 100% of the prescribed dose (R100) was a significant predictive parameter for late GI toxicity. Conclusions The boost group showed higher incidence rates of both GU and GI toxicity. Higher IPSS before seed implantation, combination with EBRT and a higher R100 were significant predictors for acute GU, late GU and late GI toxicity. PMID:23363647

  6. Periodical assessment of genitourinary and gastrointestinal toxicity in patients who underwent prostate low-dose-rate brachytherapy.

    PubMed

    Tanaka, Nobumichi; Asakawa, Isao; Anai, Satoshi; Hirayama, Akihide; Hasegawa, Masatoshi; Konishi, Noboru; Fujimoto, Kiyohide

    2013-01-30

    To compare the periodical incidence rates of genitourinary (GU) and gastrointestinal (GI) toxicity in patients who underwent prostate low-dose-rate brachytherapy between the monotherapy group (seed implantation alone) and the boost group (in combination with external beam radiation therapy (EBRT)). A total of 218 patients with a median follow-up of 42.5 months were enrolled. The patients were divided into 2 groups by treatment modality, namely, the monotherapy group (155 patients) and the boost group (63 patients). The periodical incidence rates of GU and GI toxicity were separately evaluated and compared between the monotherapy group and the boost group using the National Cancer Institute - Common Terminology Criteria for Adverse Events, version 3.0. To elucidate an independent factor among clinical and postdosimetric parameters to predict grade 2 or higher GU and GI toxicity in the acute and late phases, univariate and multivariate logistic regression analyses were carried out. Of all patients, 78.0% showed acute GU toxicity, and 7.8% showed acute GI toxicity, while 63.8% showed late GU toxicity, and 21.1% showed late GI toxicity. The incidence rates of late GU and GI toxicity were significantly higher in the boost group. Multivariate analysis showed that the International Prostate Symptom Score (IPSS) before seed implantation was a significant parameter to predict acute GU toxicity, while there were no significant predictive parameters for acute GI toxicity. On the other hand, combination with EBRT was a significant predictive parameter for late GU toxicity, and rectal volume (mL) receiving 100% of the prescribed dose (R100) was a significant predictive parameter for late GI toxicity. The boost group showed higher incidence rates of both GU and GI toxicity. Higher IPSS before seed implantation, combination with EBRT and a higher R100 were significant predictors for acute GU, late GU and late GI toxicity.

  7. SU-E-T-546: Use of Implant Volume for Quality Assurance of Low Dose Rate Brachytherapy Treatment Plans

    SciTech Connect

    Wilkinson, D; Kolar, M

    2014-06-01

    Purpose: To analyze the application of volume implant (V100) data as a method for a global check of low dose rate (LDR) brachytherapy plans. Methods: Treatment plans for 335 consecutive patients undergoing permanent seed implants for prostate cancer and for 113 patients treated with plaque therapy for ocular melanoma were analyzed. Plaques used were 54 COMS (10 to 20 mm, notched and regular) and 59 Eye Physics EP917s with variable loading. Plots of treatment time x implanted activity per unit dose versus v100 ^.667 were made. V100 values were obtained using dose volume histograms calculated by the treatment planning systems (Variseed 8.02 and Plaque Simulator 5.4). Four different physicists were involved in planning the prostate seed cases; two physicists for the eye plaques. Results: Since the time and dose for the prostate cases did not vary, a plot of implanted activity vs V100 ^.667 was made. A linear fit with no intercept had an r{sup 2} = 0.978; more than 94% of the actual activities fell within 5% of the activities calculated from the linear fit. The greatest deviations were in cases where the implant volumes were large (> 100 cc). Both COMS and EP917 plaque linear fits were good (r{sup 2} = .967 and .957); the largest deviations were seen for large volumes. Conclusions: The method outlined here is effective for checking planning consistency and quality assurance of two types of LDR brachytherapy treatment plans (temporary and permanent). A spreadsheet for the calculations enables a quick check of the plan in situations were time is short (e.g. OR-based prostate planning)

  8. Monte Carlo calibration of the SMM gamma ray spectrometer for high energy gamma rays and neutrons

    NASA Technical Reports Server (NTRS)

    Cooper, J. F.; Reppin, C.; Forrest, D. J.; Chupp, E. L.; Share, G. H.; Kinzer, R. L.

    1985-01-01

    The Gamma Ray Spectrometer (GRS) on the Solar Maximum Mission spacecraft was primarily designed and calibrated for nuclear gamma ray line measurements, but also has a high energy mode which allows the detection of gamma rays at energies above 10 MeV and solar neutrons above 20 MeV. The GRS response has been extrapolated until now for high energy gamma rays from an early design study employing Monte Carlo calculations. The response to 50 to 600 MeV solar neutrons was estimated from a simple model which did not consider secondary charged particles escaping into the veto shields. In view of numerous detections by the GRS of solar flares emitting high energy gamma rays, including at least two emitting directly detectable neutrons, the calibration of the high energy mode in the flight model has been recalculated by the use of more sophisticated Monte Carlo computer codes. New results presented show that the GRS response to gamma rays above 20 MeV and to neutrons above 100 MeV is significantly lower than the earlier estimates.

  9. Gamma ray constraints on the Galactic supernova rate

    NASA Technical Reports Server (NTRS)

    Hartmann, D.; The, L.-S.; Clayton, Donald D.; Leising, M.; Mathews, G.; Woosley, S. E.

    1991-01-01

    We perform Monte Carlo simulations of the expected gamma ray signatures of Galactic supernovae of all types to estimate the significance of the lack of a gamma ray signal due to supernovae occurring during the last millenium. Using recent estimates of the nuclear yields, we determine mean Galactic supernova rates consistent with the historic supernova record and the gamma ray limits. Another objective of these calculations of Galactic supernova histories is their application to surveys of diffuse Galactic gamma ray line emission.

  10. Applications of Monte Carlo simulations of gamma-ray spectra

    SciTech Connect

    Clark, D.D.

    1995-12-31

    A short, convenient computer program based on the Monte Carlo method that was developed to generate simulated gamma-ray spectra has been found to have useful applications in research and teaching. In research, we use it to predict spectra in neutron activation analysis (NAA), particularly in prompt gamma-ray NAA (PGNAA). In teaching, it is used to illustrate the dependence of detector response functions on the nature of gamma-ray interactions, the incident gamma-ray energy, and detector geometry.

  11. Simultaneous optical/gamma-ray observations of GRBs

    NASA Technical Reports Server (NTRS)

    Greiner, J.; Wenzel, W.; Hudec, R.; Moskalenko, E. I.; Metlov, V.; Chernych, N. S.; Getman, V. S.; Ziener, Rainer; Birkle, K.; Bade, N.

    1994-01-01

    Details on the project to search for serendipitous time correlated optical photographic observations of Gamma Ray Bursters (GRB's) are presented. The ongoing photographic observations at nine observatories are used to look for plates which were exposed simultaneously with a gamma ray burst detected by the gamma ray instrument team (BATSE) and contain the burst position. The results for the first two years of the gamma ray instrument team operation are presented.

  12. Gamma-ray astronomy--A status report

    NASA Technical Reports Server (NTRS)

    Holt, Stephen S.

    1994-01-01

    Gamma-rays provide us with powerful insight into the highest energy processes occurring in the cosmos. This review highlights some of the progress in our understanding of gamma-ray astronomy that has been enabled by new data from GRANAT and the Compton Gamma-Ray Observaatory, and suggests requirements for future progress. In particular, the unique role of the International Gamma-Ray Astrophysics Laboratory (INTEGRAL) mission and concurrent multiwavelength observations is highlighted.

  13. Very High-Energy Gamma-Ray Sources.

    ERIC Educational Resources Information Center

    Weekes, Trevor C.

    1986-01-01

    Discusses topics related to high-energy, gamma-ray astronomy (including cosmic radiation, gamma-ray detectors, high-energy gamma-ray sources, and others). Also considers motivation for the development of this field, the principal results to date, and future prospects. (JN)

  14. Gamma-Ray Telescopes: 400 Years of Astronomical Telescopes

    NASA Technical Reports Server (NTRS)

    Gehrels, Neil; Cannizzo, John K.

    2010-01-01

    The last half-century has seen dramatic developments in gamma-ray telescopes, from their initial conception and development through to their blossoming into full maturity as a potent research tool in astronomy. Gamma-ray telescopes are leading research in diverse areas such as gamma-ray bursts, blazars, Galactic transients, and the Galactic distribution of Al-26.

  15. Radon concentration monitoring using xenon gamma-ray spectrometer

    NASA Astrophysics Data System (ADS)

    Novikov, A.; Ulin, S.; Dmitrenko, V.; Chernysheva, I.; Grachev, V.; Vlasik, K.; Uteshev, Z.; Shustov, A.; Petrenko, D.; Bychkova, O.

    2017-01-01

    A method for 222Rn concentration monitoring by means of intensity measurement of its daughter nuclei (214Pb and 214Bi) gamma-ray emission using xenon gamma-ray spectrometer is presented. Testing and calibration results for a gamma-spectrometric complex based on xenon gamma-ray detector are described.

  16. Very High-Energy Gamma-Ray Sources.

    ERIC Educational Resources Information Center

    Weekes, Trevor C.

    1986-01-01

    Discusses topics related to high-energy, gamma-ray astronomy (including cosmic radiation, gamma-ray detectors, high-energy gamma-ray sources, and others). Also considers motivation for the development of this field, the principal results to date, and future prospects. (JN)

  17. Astrophysical constraints from gamma-ray spectroscopy

    NASA Astrophysics Data System (ADS)

    Diehl, Roland; Prantzos, Nikos; von Ballmoos, Peter

    2006-10-01

    Gamma-ray lines from cosmic sources provide unique isotopic information, since they originate from energy level transitions in the atomic nucleus. Gamma-ray telescopes explored this astronomical window in the past three decades, detecting radioactive isotopes that have been ejected in interstellar space by cosmic nucleosynthesis events and nuclei that have been excited through collisions with energetic particles. Astronomical gamma-ray telescopes feature standard detectors of nuclear physics, but have to be surrounded by effective shields against local instrumental background, and need special detector and/or mask arrangements to collect imaging information. Due to exceptionally-low signal/noise ratios, progress in the field has been slow compared with other wavelengths. Despite the difficulties, this young field of astronomy is well established now, in particular due to advances made by the Compton Gamma-Ray Observatory in the 90ies. The most important achievements so far concern: short-lived radioactivities that have been detected in a couple of supernovae (56Co and 57Co in SN1987A, 44Ti in Cas A), the diffuse glow of long-lived 26Al that has been mapped along the entire plane of the Galaxy, several excited nuclei that have been detected in solar flares, and, last but not least, positron annihilation that has been observed in the inner Galaxy since the 70ies. High-resolution spectroscopy is now being performed: since 2002, ESAs INTEGRAL and NASAs RHESSI, two space-based gamma-ray telescopes with Ge detectors, are in operation. Recent results include: imaging and line shape measurements of e e annihilation emission from the Galactic bulge, which can hardly be accounted for by conventional sources of positrons; 26Al emission and line width measurement from the inner Galaxy and from the Cygnus region, which can constrain the properties of the interstellar medium; and a diffuse 60Fe gamma-ray line emission which appears rather weak, in view of current theoretical

  18. Detection of high-energy gamma rays from winter thunderclouds.

    PubMed

    Tsuchiya, H; Enoto, T; Yamada, S; Yuasa, T; Kawaharada, M; Kitaguchi, T; Kokubun, M; Kato, H; Okano, M; Nakamura, S; Makishima, K

    2007-10-19

    A report is made on a comprehensive observation of a burstlike gamma-ray emission from thunderclouds on the Sea of Japan, during strong thunderstorms on 6 January 2007. The detected emission, lasting for approximately 40 sec, preceded cloud-to-ground lightning discharges. The burst spectrum, extending to 10 MeV, can be interpreted as consisting of bremsstrahlung photons originating from relativistic electrons. This ground-based observation provides the first clear evidence that strong electric fields in thunderclouds can continuously accelerate electrons beyond 10 MeV prior to lightning discharges.

  19. Fabrication of collimators for gamma-ray imaging.

    SciTech Connect

    Makarova, O. V.; Yang, G.; Tang, C.-M.; Mancini, D. C.; Divan, R.; Yaeger, J.; Experimental Facilities Division; Creatv Micro Tech, Inc.

    2004-01-01

    Collimators capable of higher resolution and optimized for greater sensitivity can significantly improve the imaging quality of gamma-cameras for single-photon-emission computed tomography of small animals. We are applying deep x-ray lithography and gold electroforming techniques to fabricate high-resolution collimators with continuous, smooth, and thin septa. Negative SU-8 photoresist was used for mold fabrication. To be efficient, collimators for gamma-cameras designed to image 140 keV gamma-rays should be over 1.5 cm tall. The height of the collimator can be achieved by stacking the appropriate number of layers.

  20. Characterization of the neutron irradiation system for use in the Low-Dose-Rate Irradiation Facility at Sandia National Laboratories.

    SciTech Connect

    Franco, Manuel

    2014-08-01

    The objective of this work was to characterize the neutron irradiation system consisting of americium-241 beryllium (241AmBe) neutron sources placed in a polyethylene shielding for use at Sandia National Laboratories (SNL) Low Dose Rate Irradiation Facility (LDRIF). With a total activity of 0.3 TBq (9 Ci), the source consisted of three recycled 241AmBe sources of different activities that had been combined into a single source. The source in its polyethylene shielding will be used in neutron irradiation testing of components. The characterization of the source-shielding system was necessary to evaluate the radiation environment for future experiments. Characterization of the source was also necessary because the documentation for the three component sources and their relative alignment within the Special Form Capsule (SFC) was inadequate. The system consisting of the source and shielding was modeled using Monte Carlo N-Particle transport code (MCNP). The model was validated by benchmarking it against measurements using multiple techniques. To characterize the radiation fields over the full spatial geometry of the irradiation system, it was necessary to use a number of instruments of varying sensitivities. First, the computed photon radiography assisted in determining orientation of the component sources. With the capsule properly oriented inside the shielding, the neutron spectra were measured using a variety of techniques. A N-probe Microspec and a neutron Bubble Dosimeter Spectrometer (BDS) set were used to characterize the neutron spectra/field in several locations. In the third technique, neutron foil activation was used to ascertain the neutron spectra. A high purity germanium (HPGe) detector was used to characterize the photon spectrum. The experimentally measured spectra and the MCNP results compared well. Once the MCNP model was validated to an adequate level of confidence, parametric analyses was performed on the model to optimize for potential

  1. SU-E-J-232: Feasibility of MRI-Based Preplan On Low Dose Rate Prostate Brachytherapy

    SciTech Connect

    Huang, Y; Tward, J; Rassiah-Szegedi, P; Zhao, H; Sarkar, V; Huang, L; Szegedi, M; Kokeny, K; Salter, B

    2015-06-15

    Purpose: To investigate the feasibility of using MRI-based preplan for low dose rate prostate brachytherapy. Methods: 12 patients who received transrectal ultrasound (TRUS) guided prostate brachytherapy with Pd-103 were retrospectively studied. Our care-standard of the TRUS-based preplan served as the control. One or more prostate T2-weighted wide and/or narrow-field of view MRIs obtained within the 3 months prior to the implant were imported into the MIM Symphony software v6.3 (MIM Software Inc., Cleveland, OH) for each patient. In total, 37 MRI preplans (10 different image sequences with average thickness of 4.8mm) were generated. The contoured prostate volume and the seed counts required to achieve adequate dosimetric coverage from TRUS and MRI preplans were compared for each patient. The effects of different MRI sequences and image thicknesses were also investigated statistically using Student’s t-test. Lastly, the nomogram from the MRI preplan and TRUS preplan from our historical treatment data were compared. Results: The average prostate volume contoured on the TRUS and MRI were 26.6cc (range: 12.6∼41.3cc), and 27.4 cc (range: 14.3∼50.0cc), respectively. Axial MRI thicknesses (range: 3.5∼8.1mm) did not significantly affect the contoured volume or the number of seeds required on the preplan (R2 = 0.0002 and 0.0012, respectively). Four of the MRI sequences (AX-T2, AX-T2-Whole-Pelvis, AX-T2-FSE, and AXIALT2- Hi-Res) showed statistically significant better prostate volume agreement with TRUS than the other seven sequences (P <0.01). Nomogram overlay between the MRI and TRUS preplans showed good agreement; indicating volumes contoured on MRI preplan scan reliably predict how many seeds are needed for implant. Conclusion: Although MRI does not allow for determination of the actual implant geometry, it can give reliable volumes for seed ordering purposes. Our future work will investigate if MRI is sufficient to reliably replace TRUS preplanning in patients

  2. SU-E-T-34: An in Vivo Study On Pulsed Low Dose-Rate Radiotherapy for Prostate Cancer

    SciTech Connect

    Wang, B; Cvetkovic, D; Chen, L; Ma, C; Chen, X; Zhang, P; Zhang, C

    2014-06-01

    Purpose: Re-irradiation with conventional radiotherapy techniques (CRT) may pose significant risks due to high accumulative radiation doses. Pulsed low dose-rate radiotherapy (PLDR) has been used in clinical trials for recurrent cancer treatment. In our previous studies, PLDR irradiation showed significantly lower toxicity than CRT, resulting in much longer survival of mice after PLDR total body irradiation (TBI) than conventional TBI. The purpose of this study was to investigate tumor control efficacy of PLDR treatment for prostate cancer with an animal model of prostate cancer LNCaP. Methods: We used an orthotopic murine model of LNCaP cell line for this study. LNCaP cells were implanted into immune-suppressed male nude mice via surgery. We monitored the tumor growth with MRI. The tumor-bearing mice were allocated into a PLDR(n=9), CRT(n=7), and control group(n=7) randomly. The mice in the PLDR and CRT groups were irradiated with 2Gy dose for one time. For the CRT treatment, the mice received 2Gy at a dose-rate of 300 MU/minute. For the PLDR treatment, the 2Gy dose was further divided into ten pulses of 0.2Gy at the same dose-rate with an interval of 3 minutes between the pulses. Results: Sizable tumor growth delays were observed for the PLDR and CRT groups through weekly MRI scans. The mean values of the normalized tumor volumes (± standard deviation of the mean) were 1.53±0.07, 1.53±0.14, and 1.81±0.09 at one week after treatment, 2.28±0.13, 2.19±0.16, and 3.04±0.25 at two weeks after treatment, and 3.31±0.23, 3.14±0.24 and 4.62±0.49 at three weeks after treatment, for the PLDR, CRT, and control groups, respectively. Conclusion: The PLDR and CRT treatments showed comparable tumor control rates in this study. Our in vivo results indicate that PLDR may be a viable option for treating recurrent prostate cancer due to its equivalent tumor control but low normal tissue toxocities.

  3. Evaluation of a Machine-Learning Algorithm for Treatment Planning in Prostate Low-Dose-Rate Brachytherapy.

    PubMed

    Nicolae, Alexandru; Morton, Gerard; Chung, Hans; Loblaw, Andrew; Jain, Suneil; Mitchell, Darren; Lu, Lin; Helou, Joelle; Al-Hanaqta, Motasem; Heath, Emily; Ravi, Ananth

    2017-03-15

    This work presents the application of a machine learning (ML) algorithm to automatically generate high-quality, prostate low-dose-rate (LDR) brachytherapy treatment plans. The ML algorithm can mimic characteristics of preoperative treatment plans deemed clinically acceptable by brachytherapists. The planning efficiency, dosimetry, and quality (as assessed by experts) of preoperative plans generated with an ML planning approach was retrospectively evaluated in this study. Preimplantation and postimplantation treatment plans were extracted from 100 high-quality LDR treatments and stored within a training database. The ML training algorithm matches similar features from a new LDR case to those within the training database to rapidly obtain an initial seed distribution; plans were then further fine-tuned using stochastic optimization. Preimplantation treatment plans generated by the ML algorithm were compared with brachytherapist (BT) treatment plans in terms of planning time (Wilcoxon rank sum, α = 0.05) and dosimetry (1-way analysis of variance, α = 0.05). Qualitative preimplantation plan quality was evaluated by expert LDR radiation oncologists using a Likert scale questionnaire. The average planning time for the ML approach was 0.84 ± 0.57 minutes, compared with 17.88 ± 8.76 minutes for the expert planner (P=.020). Preimplantation plans were dosimetrically equivalent to the BT plans; the average prostate V150% was 4% lower for ML plans (P=.002), although the difference was not clinically significant. Respondents ranked the ML-generated plans as equivalent to expert BT treatment plans in terms of target coverage, normal tissue avoidance, implant confidence, and the need for plan modifications. Respondents had difficulty differentiating between plans generated by a human or those generated by the ML algorithm. Prostate LDR preimplantation treatment plans that have equivalent quality to plans created by brachytherapists can be rapidly generated using ML

  4. Neutron-driven gamma-ray laser

    DOEpatents

    Bowman, Charles D.

    1990-01-01

    A lasing cylinder emits laser radiation at a gamma-ray wavelength of 0.87 .ANG. when subjected to an intense neutron flux of about 400 eV neutrons. A 250 .ANG. thick layer of Be is provided between two layers of 100 .ANG. thick layer of .sup.57 Co and these layers are supported on a foil substrate. The coated foil is coiled to form the lasing cylinder. Under the neutron flux .sup.57 Co becomes .sup.58 Co by neutron absorption. The .sup.58 Co then decays to .sup.57 Fe by 1.6 MeV proton emission. .sup.57 Fe then transitions by mesne decay to a population inversion for lasing action at 14.4 keV. Recoil from the proton emission separates the .sup.57 Fe from the .sup.57 Co and into the Be, where Mossbauer emission occurs at a gamma-ray wavelength.

  5. The diffuse galactic gamma ray emission

    NASA Technical Reports Server (NTRS)

    Bertsch, David L.

    1990-01-01

    The EGRET (Energetic Gamma-Ray Experiment Telescope) detector will provide a much more detailed view of the diffuse galactic gamma ray intensity in terms of higher resolution, greater statistical significance, and broader energy range than earlier missions. These observations will furnish insight into a number of very important questions related to the dynamics and structure of the Galaxy. A diffuse emission model is being developed that incorporates the latest information on matter distribution and source functions. In addition, it is tailored to the EGRET instrument response functions. The analysis code of the model maintains flexibility to accommodate the quality of the data that is anticipated. The discussion here focuses on the issues of the distributions of matter, cosmic rays, and radiation fields, and on the important source functions that enter into the model calculation of diffuse emission.

  6. The gamma ray north-south effect

    NASA Technical Reports Server (NTRS)

    White, R. S.; O'Neill, T. J.; Tumer, O. T.; Zych, A. D.

    1988-01-01

    Theoretical calculations are presented that explain the balloon observations by O'Neill et al. (1987) of a strong north-south anisotropy of atmospheric gamma rays over the Southern Hemisphere, and to predict the north-south ratios. It is shown that the gamma rays that originate at the longest distances from the telescopes give the largest north-south ratios. Comparisons are made of the experimental north-south ratios measured on balloons launched from Alice Springs, Australia, and from Palestine, Texas, U.S., and predictions are made for ratios at other geomagnetic latitudes and longitudes. It is pointed out that observers who measure backgrounds for celestial sources may be misled unless they correct for the north-south effect.

  7. Research in cosmic and gamma ray astrophysics

    NASA Technical Reports Server (NTRS)

    Stone, Edward C.; Mewaldt, Richard A.; Prince, Thomas A.

    1992-01-01

    Discussed here is research in cosmic ray and gamma ray astrophysics at the Space Radiation Laboratory (SRL) of the California Institute of Technology. The primary activities discussed involve the development of new instrumentation and techniques for future space flight. In many cases these instrumentation developments were tested in balloon flight instruments designed to conduct new investigations in cosmic ray and gamma ray astrophysics. The results of these investigations are briefly summarized. Specific topics include a quantitative investigation of the solar modulation of cosmic ray protons and helium nuclei, a study of cosmic ray positron and electron spectra in interplanetary and interstellar space, the solar modulation of cosmic rays, an investigation of techniques for the measurement and interpretation of cosmic ray isotopic abundances, and a balloon measurement of the isotopic composition of galactic cosmic ray boron, carbon, and nitrogen.

  8. SuperAGILE and Gamma Ray Bursts

    SciTech Connect

    Pacciani, Luigi; Costa, Enrico; Del Monte, Ettore; Donnarumma, Immacolata; Evangelista, Yuri; Feroci, Marco; Frutti, Massimo; Lazzarotto, Francesco; Lapshov, Igor; Rubini, Alda; Soffitta, Paolo; Tavani, Marco; Barbiellini, Guido; Mastropietro, Marcello; Morelli, Ennio; Rapisarda, Massimo

    2006-05-19

    The solid-state hard X-ray imager of AGILE gamma-ray mission -- SuperAGILE -- has a six arcmin on-axis angular resolution in the 15-45 keV range, a field of view in excess of 1 steradian. The instrument is very light: 5 kg only. It is equipped with an on-board self triggering logic, image deconvolution, and it is able to transmit the coordinates of a GRB to the ground in real-time through the ORBCOMM constellation of satellites. Photon by photon Scientific Data are sent to the Malindi ground station at every contact. In this paper we review the performance of the SuperAGILE experiment (scheduled for a launch in the middle of 2006), after its first onground calibrations, and show the perspectives for Gamma Ray Bursts.

  9. SUB-LUMINOUS {gamma}-RAY PULSARS

    SciTech Connect

    Romani, R. W.; Kerr, M.; Craig, H. A.; Johnston, S.; Cognard, I.; Smith, D. A.

    2011-09-01

    Most pulsars observed by the Fermi Large Area Telescope have {gamma}-ray luminosities scaling with spin-down power E-dot as L{sub {gamma}}{approx}(E-dot x 10{sup 33} erg s{sup -1}){sup 1/2}. However, there exist one detection and several upper limits an order of magnitude or more fainter than this trend. We describe these 'sub-luminous' {gamma}-ray pulsars and discuss the case for this being an orientation effect. Of the 12 known young radio pulsars with E-dot >10{sup 34} erg s{sup -1} and d {<=} 2 kpc several are substantially sub-luminous. The limited available geometrical constraints favor aligned geometries for these pulsars, although no one case for alignment is compelling. In this scenario GeV emission detected from such sub-luminous pulsars can be due to a lower altitude, lower-power accelerator gap.

  10. Solar flare gamma-ray line shapes

    NASA Technical Reports Server (NTRS)

    Werntz, C.; Kim, Y. E.; Lang, Frederick L.

    1990-01-01

    A computer code has been developed which is used to calculate ab initio the laboratory shapes and energy shifts of gamma-ray lines from (C-12)(p, gamma/4.438/)p-prime(C-12) and (O-16)(p, gamma/6.129/)p-prime(O-16) reactions and to calculate the expected shapes of these lines from solar flares. The sensitivity of observable solar flare gamma-ray line shapes to the directionality of the incident particles is investigated for several projectile angular distributions. Shapes of the carbon and oxygen lines are calculated assuming realistic proton energy spectra for particles in circular orbits at the mirror points of magnetic loops, for particle beams directed downward into the photosphere, and for isotropic particle distributions. Line shapes for flare sites near the center of the sun and on the limb are shown for both thin-target and thick-target interaction models.

  11. The GAMCIT gamma ray burst detector

    NASA Technical Reports Server (NTRS)

    Mccall, Benjamin J.; Grunsfeld, John M.; Sobajic, Srdjan D.; Chang, Chinley Leonard; Krum, David M.; Ratner, Albert; Trittschuh, Jennifer E.

    1993-01-01

    The GAMCIT payload is a Get-Away-Special payload designed to search for high-energy gamma-ray bursts and any associated optical transients. This paper presents details on the design of the GAMCIT payload, in the areas of battery selection, power processing, electronics design, gamma-ray detection systems, and the optical imaging of the transients. The paper discusses the progress of the construction, testing, and specific design details of the payload. In addition, this paper discusses the unique challenges involved in bringing this payload to completion, as the project has been designed, constructed, and managed entirely by undergraduate students. Our experience will certainly be valuable to other student groups interested in taking on a challenging project such as a Get-Away-Special payload.

  12. Prompt Radio Emission from Gamma Ray Bursts

    NASA Astrophysics Data System (ADS)

    Gotthardt, Noelle

    2010-02-01

    Gamma-ray bursts have been observed, but these enigmatic objects are yet unexplained. These short duration events are undoubtedly due to high-energy events. Fading optical emission and even radio emission has been observed from such events, but prompt radio emission from these events would be very useful in pinning down the physics of the bursts, the nature of the progenitor object,and possibly the medium in which it occurs. If these phenomena occur at large redshifts, there is the possibility that the observations could probe the Epoch of Reionization, or the intergalactic medium. A number of models have been proposed to explain the gamma-ray bursts, ranging from compact object mergers, to maser-like coherent emission. These models are not well constrained by current observations. Prompt radio emission may be detected by a transient radio array. I will discuss a planned search for such signals by the Eight-meter-wavelength Transient Array (ETA). )

  13. Fissile interrogation using gamma rays from oxygen

    DOEpatents

    Smith, Donald; Micklich, Bradley J.; Fessler, Andreas

    2004-04-20

    The subject apparatus provides a means to identify the presence of fissionable material or other nuclear material contained within an item to be tested. The system employs a portable accelerator to accelerate and direct protons to a fluorine-compound target. The interaction of the protons with the fluorine-compound target produces gamma rays which are directed at the item to be tested. If the item to be tested contains either a fissionable material or other nuclear material the interaction of the gamma rays with the material contained within the test item with result in the production of neutrons. A system of neutron detectors is positioned to intercept any neutrons generated by the test item. The results from the neutron detectors are analyzed to determine the presence of a fissionable material or other nuclear material.

  14. Stirling Colgate and Gamma-Ray Bursts

    NASA Astrophysics Data System (ADS)

    Lamb, Donald

    2014-10-01

    Even before the discovery of gamma-ray bursts (GRBs), Stirling Colgate proposed that bursts of x rays and gamma rays might be produced by a relativistic shock created in the supernova explosion of a massive star. We trace the scientific story of GRBs from their detection to the present, highlighting along the way Stirling's interest in them and his efforts to understand them. We summarize our current understanding that short, soft, repeating bursts are produced by magnetic neutron stars; short, hard bursts are produced by the mergers of neutron star-neutron star binaries; and long, hard bursts are produced by the core collapse of massive stars that have lost their hydrogen and helium envelopes. We then discuss some important open questions about GRBs and how they might be answered. We conclude by describing the recent serendipitous discovery of an x-ray burst of exactly the kind he proposed, and the insights into core collapse supernovae and GRBs that it provided.

  15. Nuclear isomer suitable for gamma ray laser

    NASA Technical Reports Server (NTRS)

    Jha, S.

    1979-01-01

    The operation of gamma ray lasers (gasers) are studied. It is assumed that the nuclear isomers mentioned in previously published papers have inherent limitations. It is further assumed that the judicious use of Bormann effect or the application of the total external reflection of low energy gamma radiation at grazing angle of incidence may permit the use of a gaser crystal sufficiently long to achieve observable stimulated emission. It is suggested that a long lived 0(+) isomer decaying by low energy gamma ray emission to a short lived 2(+) excited nuclear state would be an attractive gaser candidate. It is also suggested that the nuclear isomer be incorporated in a matrix of refractory material having an electrostatic field gradient whose principal axis lies along the length of the medium. This results in the preferential transmission of electric quadrupole radiation along the length of the medium.

  16. Nucleosynthesis and astrophysical gamma ray spectroscopy

    NASA Technical Reports Server (NTRS)

    Jacobson, Allan S.

    1987-01-01

    The HEAO-3 gamma ray spectrometer has provided evidence in the quest for the understanding of complex element formation in the universe with the discovery of Al-26 in the interstellar medium. It has demonstrated that the synthesis of intermediate mass nuclei is currently going on in the galaxy. This discovery was confirmed by the Solar Maximum Mission. The flux is peaked near the galactic center and indicates about 3 solar masses of Al-26 in the interstellar medium, with an implied ratio of Al-26/Al-27 = .00001. Several possible distributions were studied but the data gathered thus far do not allow discrimination between them. It is felt that only the spaceflight of a high resolution gamma ray spectrometer with adequate sensitivity will ultimately resolve the issue of the source of this material.

  17. Real time gamma-ray signature identifier

    DOEpatents

    Rowland, Mark [Alamo, CA; Gosnell, Tom B [Moraga, CA; Ham, Cheryl [Livermore, CA; Perkins, Dwight [Livermore, CA; Wong, James [Dublin, CA

    2012-05-15

    A real time gamma-ray signature/source identification method and system using principal components analysis (PCA) for transforming and substantially reducing one or more comprehensive spectral libraries of nuclear materials types and configurations into a corresponding concise representation/signature(s) representing and indexing each individual predetermined spectrum in principal component (PC) space, wherein an unknown gamma-ray signature may be compared against the representative signature to find a match or at least characterize the unknown signature from among all the entries in the library with a single regression or simple projection into the PC space, so as to substantially reduce processing time and computing resources and enable real-time characterization and/or identification.

  18. The future of gamma-ray astronomy

    NASA Astrophysics Data System (ADS)

    Knödlseder, Jürgen

    2016-06-01

    The field of gamma-ray astronomy has experienced impressive progress over the last decade. Thanks to the advent of a new generation of imaging air Cherenkov telescopes (H.E.S.S., MAGIC, VERITAS) and thanks to the launch of the Fermi-LAT satellite, several thousand gamma-ray sources are known today, revealing an unexpected ubiquity of particle acceleration processes in the Universe. Major scientific challenges are still ahead, such as the identification of the nature of Dark Matter, the discovery and understanding of the sources of cosmic rays, or the comprehension of the particle acceleration processes that are at work in the various objects. This paper presents some of the instruments and mission concepts that will address these challenges over the next decades.

  19. Plasma Instabilities in Gamma-Ray Bursts

    SciTech Connect

    Tautz, Robert C.

    2008-12-24

    Magnetic fields are important in a variety of astrophysical scenarios, ranging from possible creation mechanisms of cosmological magnetic fields through relativistic jets such as that from Active Galactic Nuclei and gamma-ray bursts to local phenomena in the solar system. Here, the outstanding importance of plasma instabilities to astrophysics is illustrated by applying the so-called neutral point method to gamma-ray bursts (GRBs), which are assumed to have a homogeneous background magnetic field. It is shown how magnetic turbulence, which is a prerequisite for the creation of dissipation and, subsequently, radiation, is created by the highly relativistic particles in the GRB jet. Using the fact that different particle compositions lead to different instability conditions, conclusions can be drawn about the particle composition of the jet, showing that it is more likely of baryonic nature.

  20. Current Topics in Gamma-Ray Astrophysics

    PubMed Central

    Mathews, Grant J.; Maronetti, P.; Salmonson, Jay; Wilson, J. R.

    2000-01-01

    This paper reports on recent progress toward unraveling the origin of gamma-ray bursts. It is concluded that neutron-star binaries are one of the few remaining candidates. A model is proposed based upon general relativistic hydrodynamic studies which indicate a new physical process by which to power a gamma-ray burst. Relativistically driven compression, heating, and collapse of the individual neutron stars can occur many seconds before inspiral and merger. This compression may produce a neutrino burst of ∼1053 ergs lasting several seconds. The associated thermal neutrino emission produces an e+–e − pair plasma by vv¯ annihilation. We show first results of a simulated burst which produces ∼1051 erg in γ rays of the correct spectral and temporal properties. PMID:27551592

  1. Stirling Colgate and Gamma-Ray Bursts

    NASA Astrophysics Data System (ADS)

    Lamb, Donald

    2014-10-01

    Even before the discovery of gamma-ray bursts (GRBs), Stirling Colgate proposed that bursts of x rays and gamma rays might be produced by a relativistic shock created in the supernova explosion of a massive star. We trace the scientific story of GRBs from their detection to the present, highlighting along the way Stirling's interest in them and his efforts to understand them. We summarize our current understanding that short, soft, repeating bursts are produced by magnetic neutron stars; short, hard bursts are produced by the mergers of neutron star-neutron star binaries; and long, hard bursts are produced by the core collapse of massive stars that have lost their hydrogen and helium envelopes. We then discuss some important open questions about GRBs and how they might be answered. We conclude by describing the recent serendipitous discovery of an x-ray burst of exactly the kind he proposed, and the insights into core collapse supernovae and GRBs that it provided.

  2. Neutrino flux from observable Gamma Ray Bursts

    NASA Astrophysics Data System (ADS)

    Spada, M.; Guetta, D.; Waxman, E.

    2000-12-01

    We derive the flux and spectrum of neutrinos from Gamma Ray Bursts (GRBs), and the corresponding detection rate in a cubic-km neutrino detector, within the frame work of the Internal Shock Model. In this model, GRBs are produced by internal shocks in a highly relativistic wind, and high energy neutrinos result from photo-meson interactions of wind protons with gamma-ray photons. We show that the predicted neutrino flux is only weakly dependent on unknown wind parameters, due to the fact that observed GRB characteristics require these parameters to be strongly correlated. Thus, the predicted neutrino luminosity does not vary strongly from burst to burst. Several tens of events per year, correlated with GRBs, are expected to be detected in a cubic-km detector.

  3. The Gamma-Ray Burst Next Door

    NASA Technical Reports Server (NTRS)

    Wanjek, Christopher

    2003-01-01

    I hesitate to spawn a thousand bad sci-fi flicks, but here it goes: Scientists now say that some gamma-ray bursts, the most powerful explosions in the universe, originate in nearby galaxy clusters. If one were to occur nearby, it could wipe out life on Earth. Fortunately, the chances of mass extinction are slimmer than the Chicago Cubs meeting the Boston Red Sox in the World Series (. . . and the Red Sox winning). But a new analysis of over 1400 archived gamma-ray bursts reveals that about 100 bursts originated within 325 million light-years of Earth, and not billions of light-years away as previously thought. If so, there's no reason why a burst couldn't go off in our galaxy.

  4. The Gamma-Ray Burst Next Door

    NASA Technical Reports Server (NTRS)

    Wanjek, Christopher

    2003-01-01

    I hesitate to spawn a thousand bad sci-fi flicks, but here it goes: Scientists now say that some gamma-ray bursts, the most powerful explosions in the universe, originate in nearby galaxy clusters. If one were to occur nearby, it could wipe out life on Earth. Fortunately, the chances of mass extinction are slimmer than the Chicago Cubs meeting the Boston Red Sox in the World Series (. . . and the Red Sox winning). But a new analysis of over 1400 archived gamma-ray bursts reveals that about 100 bursts originated within 325 million light-years of Earth, and not billions of light-years away as previously thought. If so, there's no reason why a burst couldn't go off in our galaxy.

  5. Gamma Ray Bursts: a 1983 Overview

    NASA Technical Reports Server (NTRS)

    Cline, T. L.

    1983-01-01

    Gamma ray burst observations are reviewed with mention of new gamma-ray and optical transient measurements and with discussions of the controversial, contradictory and unresolved issues that have recently emerged: burst spectra appear to fluctuate in time as rapidly as they are measured, implying that any one spectrum may be incorrect; energy spectra can be obligingly fitted to practically any desired shape, implying, in effect, that no objective spectral resolution exists at all; burst fluxes and temporal quantities, including the total event energy, are characterized very differently with differing instruments, implying that even elementary knowledge of their properties is instrumentally subjective; finally, the log N-log S determinations are deficient in the weak bursts, while there is no detection of a source direction anisotropy, implying that Ptolemy was right or that burst source distance estimates are basically guesswork. These issues may remain unsolved until vastly improved instruments are flown.

  6. Gamma ray bursts: a 1983 overview

    SciTech Connect

    Cline, T.L.

    1983-10-01

    Gamma ray burst observations are reviewed with mention of new gamma-ray and optical transient measurements and with discussions of the controversial, contradictory and unresolved issues that have recently emerged: burst spectra appear to fluctuate in time as rapidly as they are measured, implying that any one spectrum may be incorrect. Energy spectra can be obligingly fitted to practically any desired shape, implying, in effect, that no objective spectral resolution exists at all. Burst fluxes and temporal quantities, including the total event energy, are characterized very differently with differing instruments, implying that even elementary knowledge of their properties is instrumentally subjective. Finally, the log N-log S determinations are deficient in the weak bursts, while there is no detection of a source direction anisotropy, implying that Ptolemy was right or that burst source distance estimates are basically guesswork. These issues may remain unsolved until vastly improved instruments are flown.

  7. Ginga Gamma-Ray Burst Line Occurrence

    NASA Technical Reports Server (NTRS)

    Band, David

    1998-01-01

    The purpose of this project is the statistical evaluation of the occurrence of spectral lines in the gamma-ray burst spectra detected by the Ginga burst detector, and the comparison of the Ginga results to the BATSE observations. Two significant line features were detected in the Ginga bursts, but thus far none have been detected in the bursts BATSE detected. These line features may indicate the presence of strong magnetic fields in bursts, and therefore are important physical diagnostics of the conditions in the plasma which radiates the observed gamma-rays. The issue is whether there is a discrepancy between the Ginga and BATSE results; the potential discrepancy must be evaluated statistically. Even if BATSE line detections are announced, the statistical methodology we have developed can be used to estimate the rate at which different types of spectral features occur.

  8. Gamma-ray imaging with germanium detectors

    NASA Astrophysics Data System (ADS)

    Mahoney, W. A.; Callas, J. L.; Ling, J. C.; Radocinski, R. G.; Skelton, R. T.; Varnell, L. S.; Wheaton, W. A.

    1993-01-01

    Externally segmented germanium detectors promise a breakthrough in gamma-ray imaging capabilities while retaining the superb energy resolution of germanium spectrometers. By combining existing position-sensitive detectors with an appropriate code aperture, two-dimensional imaging with 0.2-deg angular resolution becomes practical for a typical balloon experiment. Much finer resolutions are possible with larger separations between detectors and the coded aperture as would be applicable for space-based or lunar-based observatories. Two coaxial germanium detectors divided into five external segments have been fabricated and have undergone extensive performance evaluation and imaging testing in our laboratory. These tests together with detailed Monte Carlo modeling calculations have demonstrated the great promise of this sensor technology for future gamma-ray missions.

  9. GeV-gamma-ray emission regions

    NASA Image and Video Library

    2017-09-27

    NASA's Fermi Closes on Source of Cosmic Rays New images from NASA's Fermi Gamma-ray Space Telescope show where supernova remnants emit radiation a billion times more energetic than visible light. The images bring astronomers a step closer to understanding the source of some of the universe's most energetic particles -- cosmic rays. Fermi mapped GeV-gamma-ray emission regions (magenta) in the W44 supernova remnant. The features clearly align with filaments detectable in other wavelengths. This composite merges X-rays (blue) from the Germany-led ROSAT mission, infrared (red) from NASA's Spitzer Space Telescope, and radio (orange) from the Very Large Array near Socorro, N.M. Credit: NASA/DOE/Fermi LAT Collaboration, ROSAT, JPL-Caltech, and NRAO/AUI For more information: www.nasa.gov/mission_pages/GLAST/news/cosmic-rays-source....

  10. Gamma-ray imaging with germanium detectors

    NASA Technical Reports Server (NTRS)

    Mahoney, W. A.; Callas, J. L.; Ling, J. C.; Radocinski, R. G.; Skelton, R. T.; Varnell, L. S.; Wheaton, W. A.

    1993-01-01

    Externally segmented germanium detectors promise a breakthrough in gamma-ray imaging capabilities while retaining the superb energy resolution of germanium spectrometers. By combining existing position-sensitive detectors with an appropriate code aperture, two-dimensional imaging with 0.2-deg angular resolution becomes practical for a typical balloon experiment. Much finer resolutions are possible with larger separations between detectors and the coded aperture as would be applicable for space-based or lunar-based observatories. Two coaxial germanium detectors divided into five external segments have been fabricated and have undergone extensive performance evaluation and imaging testing in our laboratory. These tests together with detailed Monte Carlo modeling calculations have demonstrated the great promise of this sensor technology for future gamma-ray missions.

  11. Solar flare gamma-ray line shapes

    NASA Technical Reports Server (NTRS)

    Werntz, C.; Kim, Y. E.; Lang, Frederick L.

    1990-01-01

    A computer code has been developed which is used to calculate ab initio the laboratory shapes and energy shifts of gamma-ray lines from (C-12)(p, gamma/4.438/)p-prime(C-12) and (O-16)(p, gamma/6.129/)p-prime(O-16) reactions and to calculate the expected shapes of these lines from solar flares. The sensitivity of observable solar flare gamma-ray line shapes to the directionality of the incident particles is investigated for several projectile angular distributions. Shapes of the carbon and oxygen lines are calculated assuming realistic proton energy spectra for particles in circular orbits at the mirror points of magnetic loops, for particle beams directed downward into the photosphere, and for isotropic particle distributions. Line shapes for flare sites near the center of the sun and on the limb are shown for both thin-target and thick-target interaction models.

  12. Gamma Rays from Martian Dust Storms

    NASA Astrophysics Data System (ADS)

    Arabshahi, Shahab; Majid, Walid; Dwyer, Joseph; Rassoul, Hamid

    2017-04-01

    Martian dust storms are suggested to be able to generate electric fields close to the breakdown values for Mars' atmosphere, i.e. 25 kV/m [Farrel et al. 2006]. Such electric fields could initiate large electrostatic discharges on Mars [Ruf et al. 2009]. Additionally, similar to terrestrial thunderstorms, they might also be able to produce bright bursts of X-rays and gamma rays. On Earth, thunderstorm electric fields could produce avalanche of energetic electrons from single seed electron, through Møller scattering with air atoms and molecules. The process is called Relativistic Runaway Electron Avalanche (RREA), and can then generate large flux of X-rays and gamma rays through bremsstrahlung scattering. In this presentation, we have used detailed Monte Carlo simulations to study the possibility of producing large flux of energetic photon from a RREA-like mechanism inside Martian dust storms.

  13. Multi-Messenger Time-Domain Astronomy with the Fermi Gamma-ray Burst Monitor

    NASA Astrophysics Data System (ADS)

    Goldstein, Adam; Fermi GBM Team

    2017-01-01

    With exciting new detections of gravitational waves by LIGO and astrophysical neutrinos by IceCube and ANTARES, the era of multi-messenger time-domain astronomy has arrived. The Fermi Gamma-ray Burst Monitor (GBM) continuously observes the entire sky that is not occulted by the Earth in gamma-rays from 8 keV - 40 MeV with 2 microsecond temporal resolution, and that continuous data is downlinked every few hours. This wealth of near-real-time all-sky data has lead to the development of continuous data searches for gamma-ray events, such as Gamma-Ray Bursts (GRBs), in coincidence with astrophysical neutrinos and gravitational wave events. Additionally, GBM has the ability to localize triggered and un-triggered transient events to a few-degree accuracy, rapidly disseminate the alerts and localization sky maps, and there have been several successful follow-up attempts by wide-field optical telescopes, such as the Palomar Transient Factory, to catch the fading optical afterglow of GBM-triggered GRBs. We discuss the current applications and importance of Fermi GBM in leading multi-messenger time-domain astronomy in the gamma-ray regime.

  14. Prospects for Nuclear-gamma-ray Astronomy

    NASA Technical Reports Server (NTRS)

    Clayton, D. D.

    1973-01-01

    An analysis was made of prospects for gamma rays coming from two sources outside the solar system: (1) radioactive decay of fresh nuclear products to explosive nucleosynthesis, and (2) scattering of low energy cosmic rays. The former should be detectable and will provide a factual base for many suppositions about the site and history of nucleosynthesis. The latter may be detectable and, if so, will probably provide factual information about high-flux regions of cosmic radiation.

  15. Prospects for Nuclear-gamma-ray Astronomy

    NASA Technical Reports Server (NTRS)

    Clayton, D. D.

    1973-01-01

    An analysis was made of prospects for gamma rays coming from two sources outside the solar system: (1) radioactive decay of fresh nuclear products to explosive nucleosynthesis, and (2) scattering of low energy cosmic rays. The former should be detectable and will provide a factual base for many suppositions about the site and history of nucleosynthesis. The latter may be detectable and, if so, will probably provide factual information about high-flux regions of cosmic radiation.

  16. Gamma rays produce superior seedless citrus

    SciTech Connect

    Pyrah, D.

    1984-10-01

    Using gamma radiation, seedless forms of some varieties of oranges and grapefruit are being produced. Since it has long been known that radiation causes mutations in plants and animals, experiments were conducted to determine if seediness could be altered by exposing seeds or budwood to higher than natural doses of gamma radiation. Orange and grapefruit seeds and cuttings exposed to gamma rays in the early 1970's have produced trees that bear fruit superior to that now on the market.

  17. The Cannonball Model of Gamma Ray Bursts

    NASA Astrophysics Data System (ADS)

    Dar, A.

    2004-06-01

    The cannonball model (CB) of gamma ray bursts (GRBs) is incredibly more successful than the standard blast-wave models (SM) of GRBs, which suffer from profound inadequacies and limited predictive power. Te CB model is falsifiable in its hypothesis and results. Its predictions are summarized in simple analytical expressions, derived, in fair approximations, from first principles. It provides a good description on a universal basis of the properties of long-duration GRBs and of their afterglows (AGs).

  18. Gamma rays from active galactic nuclei

    NASA Technical Reports Server (NTRS)

    Kazanas, Demosthenes

    1990-01-01

    The general properties of Active Galactic Nuclei (AGN) and quasars are reviewed with emphasis on their continuum spectral emission. Two general classes of models for the continuum are outlined and critically reviewed in view of the impending GRO (Gamma Ray Observatory) launch and observations. The importance of GRO in distinguishing between these models and in general in furthering the understanding of AGN is discussed. The very broad terms the status of the current understanding of AGN are discussed.

  19. Gamma-Ray Bursts - A Cosmic Riddle

    NASA Astrophysics Data System (ADS)

    Woosley, S. E.

    1994-12-01

    A deep and abiding mystery is one of the greatest treasures nature has to offer to scientists and the public alike. Gamma-ray bursts have been observed for over 20 years. More than 2000 papers have been published about them and numerous theoretical models proposed, yet no one knows for sure what they are, where they come from, or even if they are a single class of phenomena. Isotropy and confinement (i.e., a deficiency of faint sources compared to that expected for an unbounded homogeneous sample), as exhibited in the BATSE observations from the Compton Gamma-Ray Observatory, have lead us to consider seriously only two sites - an extended Galactic halo populated by neutron stars, or else cosmologically distant sources. Models of both varieties will be reviewed. At the present time, both classes of models are given about equal credence, though ALL current models make troublesome assumptions requiring clarification. Halo models have received several boosts lately, including the realization that the mean velocity of pulsars is greater than previously thought, the certain localization of two out of three (and possibly all) soft gamma-ray repeaters to supernova remnants in our Galaxy and in the LMC, and calculations to show that under certain, albeit highly restrictive assumptions, the BATSE statistics can be satisfied by high velocity neutron stars ejected from the Galaxy. Several current halo oriented theories would like to relate the soft repeaters to the more common ``classical" bursts and claim that the former are an earlier evolutionary stage of the latter. If, on the other hand, the soft repeaters are a separate class, as the cosmologists would require, perhaps there are other classes as well. Amid all this theoretical speculation, the solution to the gamma-ray burst riddle will most likely come from further observation. Some prospects for future observations, especially with the High Energy Transient Experiment, will be briefly discussed.

  20. Gamma-ray array physics.

    SciTech Connect

    Lister, C. J.

    1999-05-25

    In this contribution I am going to discuss the development of large arrays of Compton Suppressed, High Purity Germanium (HpGe) detectors and the physics that has been, that is being, and that will be done with them. These arrays and their science have dominated low-energy nuclear structure research for the last twenty years and will continue to do so in the foreseeable future. John Sharpey Schafer played a visionary role in convincing a skeptical world that the development of these arrays would lead to a path of enlightenment. The extent to which he succeeded can be seen both through the world-wide propagation of ever more sophisticated devices, and through the world-wide propagation of his students. I, personally, would not be working in research if it were not for Johns inspirational leadership. I am eternally grateful to him. Many excellent reviews of array physics have been made in the past which can provide detailed background reading. The review by Paul Nolan, another ex-Sharpey Schafer student, is particularly comprehensive and clear.

  1. Prompt Gamma Ray Analysis of Soil Samples

    SciTech Connect

    Naqvi, A.A.; Khiari, F.Z.; Haseeb, S.M.A.; Hussein, Tanvir; Khateeb-ur-Rehman; Isab, A.H.

    2015-07-01

    Neutron moderation effects were measured in bulk soil samples through prompt gamma ray measurements from water and benzene contaminated soil samples using 14 MeV neutron inelastic scattering. The prompt gamma rays were measured using a cylindrical 76 mm x 76 mm (diameter x height) LaBr{sub 3}:Ce detector. Since neutron moderation effects strongly depend upon hydrogen concentration of the sample, for comparison purposes, moderation effects were studied from samples containing different hydrogen concentrations. The soil samples with different hydrogen concentration were prepared by mixing soil with water as well as benzene in different weight proportions. Then, the effects of increasing water and benzene concentrations on the yields of hydrogen, carbon and silicon prompt gamma rays were measured. Moderation effects are more pronounced in soil samples mixed with water as compared to those from soil samples mixed with benzene. This is due to the fact that benzene contaminated soil samples have about 30% less hydrogen concentration by weight than the water contaminated soil samples. Results of the study will be presented. (authors)

  2. Afterglow Radiation from Gamma Ray Bursts

    SciTech Connect

    Desmond, Hugh; /Leuven U. /SLAC

    2006-08-28

    Gamma-ray bursts (GRB) are huge fluxes of gamma rays that appear randomly in the sky about once a day. It is now commonly accepted that GRBs are caused by a stellar object shooting off a powerful plasma jet along its rotation axis. After the initial outburst of gamma rays, a lower intensity radiation remains, called the afterglow. Using the data from a hydrodynamical numerical simulation that models the dynamics of the jet, we calculated the expected light curve of the afterglow radiation that would be observed on earth. We calculated the light curve and spectrum and compared them to the light curves and spectra predicted by two analytical models of the expansion of the jet (which are based on the Blandford and McKee solution of a relativistic isotropic expansion; see Sari's model [1] and Granot's model [2]). We found that the light curve did not decay as fast as predicted by Sari; the predictions by Granot were largely corroborated. Some results, however, did not match Granot's predictions, and more research is needed to explain these discrepancies.

  3. Solar Two Gamma-Ray Observatory

    NASA Astrophysics Data System (ADS)

    Tümer, T.; Bhattacharya, D.; Mohideen, U.; Rieben, R.; Souchkov, V.; Tom, H.; Zweerink, J.

    1999-06-01

    The field of high energy gamma-ray astronomy grew tremendously in the last decade due to the launch of the EGRET detector on the Compton Gamma-Ray Observatory in 1991 and the proliferation of ground-based air Čherenkov telescopes (ACTs) such as the Whipple 10 meter reflector. Interestingly, the ground-based telescopes only see 4-5 of the over 170 objects detected by EGRET. A simple extrapolation of the EGRET objects' energy spectra up to the energies which the ACTs are sensitive suggests that many of them should have been detected. The key to resolving this lack of detections is to observe these sources in the previously unobserved 20-250 GeV energy range. The Solar Two Observatory collaboration is developing a secondary optics system on the central tower of the world's largest solar energy pilot plant, Solar Two, to observe gamma-ray sources in this energy range. The progress in building the secondary optics system to be used to image ˜64 heliostats at Solar Two located in Barstow, California, is presented. We hope to design and build this detector over the next 2 years.

  4. Gamma rays as an indicator of nucleosynthesis

    NASA Astrophysics Data System (ADS)

    Hartmann, Dieter H.

    2007-04-01

    In 1957 the collaboration of E. M. Burbidge, G. R. Burbidge, W. A. Fowler, and F. Hoyle, and the work by A. G. W. Cameron, laid the foundations for understanding the origin of the elements in terms of a few basic processes and astrophysical environments. Half a century after this pioneering work, there is considerable observational evidence for the basic notions of element synthesis during the big-bang, followed by hydrostatic and explosive stellar nucleosynthesis ever since the first population of stars re-illuminated the Universe, and through particle interactions in the turbulent interstellar medium. In 1969 D. D. Clayton, S. A. Colgate, and G. J. Fishman proposed to search for gamma-ray lines from the decay of 56-Ni, freshly synthesized in supernovae. Evidence for these lines was obtained for SN 1987A, and three decades after this pivotal supernova we have ample gamma-ray line evidence for ongoing nucleosynthesis in the Milky Way from surveys for individual sources and unresolved, integrated diffuse emission from an ensemble of such sources. We review the observational evidence for gamma ray lines from various species, and discuss the astrophysical implications of detections and a few puzzles suggested by lack of detections. We reflect on historic developments, assess the accomplishments, and present an outlook on the future of this branch of nuclear astrophysics.

  5. Gamma-Rays from Nucleosynthesis Ejecta

    NASA Astrophysics Data System (ADS)

    Diehl, R.

    2016-01-01

    Gamma-ray lines from radioactive decay of unstable isotopes produced in massive- star and supernova nucleosynthesis have been measured with INTEGRAL over the past ten years, complementing the earlier COMPTEL survey. 26Al has become a tool to study specific source regions, such as massive-star groups and associations in nearby regions which can be discriminated from the galactic-plane background, and the inner Galaxy where Doppler shifted lines add to the astronomical information. Recent findings are that superbubbles show a remarkable asymmetry, on average, in the spiral arms of our galaxy. 60Fe is co-produced by the sources of 26Al, and the isotopic ratio from their nucleosynthesis encodes stellar-structure information. Annihilation gamma-rays from positrons in interstellar space show a puzzling bright and extended source region central to our Galaxy, but also may be partly related to nucleosynthesis. 56Ni and 44Ti isotope gamma-rays have been used to constrain supernova explosion mechanisms. Here we summarize latest results using the accumulated multi-year database of observations, and discuss their astrophysical interpretations. We also add a comparison of isotopic ratios between the ISM of the current Galaxy and the solar vicinity at solar-system formation time.

  6. RADIO FLARES FROM GAMMA-RAY BURSTS

    SciTech Connect

    Kopač, D.; Mundell, C. G.; Kobayashi, S.; Virgili, F. J.; Harrison, R.; Japelj, J.; Gomboc, A.; Guidorzi, C.; Melandri, A.

    2015-06-20

    We present predictions of centimeter and millimeter radio emission from reverse shocks (RSs) in the early afterglows of gamma-ray bursts (GRBs) with the goal of determining their detectability with current and future radio facilities. Using a range of GRB properties, such as peak optical brightness and time, isotropic equivalent gamma-ray energy, and redshift, we simulate radio light curves in a framework generalized for any circumburst medium structure and including a parameterization of the shell thickness regime that is more realistic than the simple assumption of thick- or thin-shell approximations. Building on earlier work by Mundell et al. and Melandri et al. in which the typical frequency of the RS was suggested to lie at radio rather than optical wavelengths at early times, we show that the brightest and most distinct RS radio signatures are detectable up to 0.1–1 day after the burst, emphasizing the need for rapid radio follow-up. Detection is easier for bursts with later optical peaks, high isotropic energies, lower circumburst medium densities, and at observing frequencies that are less prone to synchrotron self-absorption effects—typically above a few GHz. Given recent detections of polarized prompt gamma-ray and optical RS emission, we suggest that detection of polarized radio/millimeter emission will unambiguously confirm the presence of low-frequency RSs at early time.

  7. Neutrino bursts from gamma-ray bursts

    NASA Technical Reports Server (NTRS)

    Paczynski, Bohdan; Xu, Guohong

    1994-01-01

    If gamma-ray bursts originate at cosmological distances, as strongly indicated by the results from Burst and Transient Source Experiment (BATSE) on the Compton Gamma-Ray Observatory (CGRO), then ultrarelativistic ejecta are the likely consequence of the highly super-Eddington luminosity of the sources. If the energy injection rate varies with time, then the Lorentz factor of the wind also varies, and the shells of ejected matter collide with each other. The collisions between baryons produce pions which decay into high-energy photons, electrons, electron positron pairs, and neutrino pairs. The bulk Lorentz factor of approximately 300 is required if our model is to be compatible with the observed millisecond variability. The strongest gamma-ray bursts are observed to deliver approximately 10(exp -4) ergs/sq cm in 100-200 keV photons. In our scenario more energy may be delivered in a neutrino burst. Typical neutrinos may be approximately 30 GeV if the protons have a Maxwellian energy distribution, and up to approximately TeV if the protons have a power-law distribution. Such neutrino bursts are close to the detection limit of the DUMAND II experiment.

  8. Distribution of Gamma-Ray Bursts

    NASA Astrophysics Data System (ADS)

    Diaz Rodriguez, Mariangelly; Smith, M.; Tešic, G.

    2014-01-01

    Gamma-Ray Bursts (GRBs) are known to be bright, irregular flashes of gamma rays that typically last just a few seconds, believed to be caused by stellar collapse or the merger of a pair of compact objects. Through previous work, it has been found that GRBs are distributed roughly uniformly over the entire sky, rather than being confined to the relatively narrow band of the Milky Way. Using the Python programming language, we generated a model of GRBs over cosmological distances, based on current empirical GRB distributions. The grbsim python module uses the acceptance-rejection Monte Carlo method to simulate the luminosity and redshift of a large population of GRBs, including cosmological effects such as dark energy and dark matter terms that modify the large-scale structure of space-time. The results of running grbsim are demonstrated to match the distribution of GRBs observed by the Burst Alert Telescope on NASA’s Swift satellite. The grbsim module will subsequently be used to simulate gamma ray and neutrino events for the Astrophysical Multimessenger Observatory Network.

  9. THE FERMI GAMMA-RAY BURST MONITOR

    SciTech Connect

    Meegan, Charles; Lichti, Giselher; Bissaldi, Elisabetta; Diehl, Roland; Greiner, Jochen; Von Kienlin, Andreas; Steinle, Helmut; Bhat, P. N.; Briggs, Michael S.; Connaughton, Valerie; Paciesas, W. S.; Preece, Robert; Wilson, Robert B.; Fishman, Gerald; Kouveliotou, Chryssa; Van der Horst, Alexander J.; McBreen, Sheila

    2009-09-01

    The Gamma-Ray Burst Monitor (GBM) will significantly augment the science return from the Fermi Observatory in the study of gamma-ray bursts (GRBs). The primary objective of GBM is to extend the energy range over which bursts are observed downward from the energy range of the Large Area Telescope (LAT) on Fermi into the hard X-ray range where extensive previous data sets exist. A secondary objective is to compute burst locations onboard to allow re-orienting the spacecraft so that the LAT can observe delayed emission from bright bursts. GBM uses an array of 12 sodium iodide scintillators and two bismuth germanate scintillators to detect gamma rays from {approx}8 keV to {approx}40 MeV over the full unocculted sky. The onboard trigger threshold is {approx}0.7 photons cm{sup -2} s{sup -1} (50-300 keV, 1 s peak). GBM generates onboard triggers for {approx}250 GRBs per year.

  10. Time correlation between the radio and gamma-ray activity in blazars and the production site of the gamma-ray emission

    DOE PAGES

    Max-Moerbeck, W.; Hovatta, T.; Richards, J. L.; ...

    2014-09-22

    In order to determine the location of the gamma-ray emission site in blazars, we investigate the time-domain relationship between their radio and gamma-ray emission. Light-curves for the brightest detected blazars from the first 3 years of the mission of the Fermi Gamma-ray Space Telescope are cross-correlated with 4 years of 15GHz observations from the OVRO 40-m monitoring program. The large sample and long light-curve duration enable us to carry out a statistically robust analysis of the significance of the cross-correlations, which is investigated using Monte Carlo simulations including the uneven sampling and noise properties of the light-curves. Modeling the light-curvesmore » as red noise processes with power-law power spectral densities, we find that only one of 41 sources with high quality data in both bands shows correlations with significance larger than 3σ (AO0235+164), with only two more larger than even 2.25σ (PKS 1502+106 and B2 2308+34). Additionally, we find correlated variability in Mrk 421 when including a strong flare that occurred in July-September 2012. These results demonstrate very clearly the difficulty of measuring statistically robust multiwavelength correlations and the care needed when comparing light-curves even when many years of data are used. This should be a caution. In all four sources the radio variations lag the gamma-ray variations, suggesting that the gamma-ray emission originates upstream of the radio emission. Continuous simultaneous monitoring over a longer time period is required to obtain high significance levels in cross-correlations between gamma-ray and radio variability in most blazars.« less

  11. Time correlation between the radio and gamma-ray activity in blazars and the production site of the gamma-ray emission

    NASA Astrophysics Data System (ADS)

    Max-Moerbeck, W.; Hovatta, T.; Richards, J. L.; King, O. G.; Pearson, T. J.; Readhead, A. C. S.; Reeves, R.; Shepherd, M. C.; Stevenson, M. A.; Angelakis, E.; Fuhrmann, L.; Grainge, K. J. B.; Pavlidou, V.; Romani, R. W.; Zensus, J. A.

    2014-11-01

    In order to determine the location of the gamma-ray emission site in blazars, we investigate the time-domain relationship between their radio and gamma-ray emission. Light curves for the brightest detected blazars from the first 3 yr of the mission of the Fermi Gamma-ray Space Telescope are cross-correlated with 4 yr of 15 GHz observations from the Owens Valley Radio Observatory 40 m monitoring programme. The large sample and long light-curve duration enable us to carry out a statistically robust analysis of the significance of the cross-correlations, which is investigated using Monte Carlo simulations including the uneven sampling and noise properties of the light curves. Modelling the light curves as red noise processes with power-law power spectral densities, we find that only one of 41 sources with high-quality data in both bands shows correlations with significance larger than 3σ (AO 0235+164), with only two more larger than even 2.25σ (PKS 1502+106 and B2 2308+34). Additionally, we find correlated variability in Mrk 421 when including a strong flare that occurred in 2012 July-September. These results demonstrate very clearly the difficulty of measuring statistically robust multiwavelength correlations and the care needed when comparing light curves even when many years of data are used. This should be a caution. In all four sources, the radio variations lag the gamma-ray variations, suggesting that the gamma-ray emission originates upstream of the radio emission. Continuous simultaneous monitoring over a longer time period is required to obtain high significance levels in cross-correlations between gamma-ray and radio variability in most blazars.

  12. Time correlation between the radio and gamma-ray activity in blazars and the production site of the gamma-ray emission

    SciTech Connect

    Max-Moerbeck, W.; Hovatta, T.; Richards, J. L.; King, O. G.; Pearson, T. J.; Readhead, A. C. S.; Reeves, R.; Shepherd, M. C.; Stevenson, M. A.; Angelakis, E.; Fuhrmann, L.; Grainge, K. J. B.; Pavlidou, V.; Romani, R. W.; Zensus, J. A.

    2014-09-22

    In order to determine the location of the gamma-ray emission site in blazars, we investigate the time-domain relationship between their radio and gamma-ray emission. Light-curves for the brightest detected blazars from the first 3 years of the mission of the Fermi Gamma-ray Space Telescope are cross-correlated with 4 years of 15GHz observations from the OVRO 40-m monitoring program. The large sample and long light-curve duration enable us to carry out a statistically robust analysis of the significance of the cross-correlations, which is investigated using Monte Carlo simulations including the uneven sampling and noise properties of the light-curves. Modeling the light-curves as red noise processes with power-law power spectral densities, we find that only one of 41 sources with high quality data in both bands shows correlations with significance larger than 3σ (AO0235+164), with only two more larger than even 2.25σ (PKS 1502+106 and B2 2308+34). Additionally, we find correlated variability in Mrk 421 when including a strong flare that occurred in July-September 2012. These results demonstrate very clearly the difficulty of measuring statistically robust multiwavelength correlations and the care needed when comparing light-curves even when many years of data are used. This should be a caution. In all four sources the radio variations lag the gamma-ray variations, suggesting that the gamma-ray emission originates upstream of the radio emission. Continuous simultaneous monitoring over a longer time period is required to obtain high significance levels in cross-correlations between gamma-ray and radio variability in most blazars.

  13. Future Prospects for Space-Based Gamma Ray Astronomy

    NASA Astrophysics Data System (ADS)

    McConnell, Mark

    2015-04-01

    The gamma-ray sky offers a unique view into broad range of astrophysical phenomena, from nearby solar flares, to galactic pulsars, to gamma-ray bursts at the furthest reaches of the Universe. The Fermi mission has dramatically demonstrated the broad range of topics that can be addressed by gamma-ray observations. The full range of gamma-ray energies is quite broad, covering the electromagnetic spectrum at energies above about 100 keV. The energy range below several hundred GeV is the domain of space-based gamma-ray observatories, a range that is not completely covered by the Fermi LAT instrument. The gamma ray community has recently embarked on an effort to define the next steps for space-based gamma ray astronomy. These discussions are being facilitated through the Gamma-ray Science Interest Group (GammaSIG), which exists to provide community input to NASA in regards to current and future needs of the gamma-ray astrophysics community. The GammaSIG, as a part of the Physics of the Cosmos Program Analysis Group, provides a forum open to all members of the gamma-ray community. The GammaSIG is currently working to bring the community together with a common vision that will be expressed in the form of a community roadmap. This talk will summarize some of the latest results from active gamma ray observatories, including both Fermi and INTEGRAL, and will summarize the status of the community roadmap effort.

  14. Local Tumor Control and Normal Tissue Toxicity of Pulsed Low-Dose Rate Radiotherapy for Recurrent Lung Cancer: An In Vivo Animal Study.

    PubMed

    Zhang, Peng; Wang, Bin; Chen, Xiaoming; Cvetkovic, Dusica; Chen, Lili; Lang, Jinyi; Ma, C-M

    2015-01-01

    This study investigates (1) local tumor control and (2) normal tissue toxicity of pulsed low-dose rate radiotherapy (PLDR) for recurrent lung cancer. For study 1, nude mice were implanted with A549 tumors and divided into the following 3 groups: (1) control (n = 10), (2) conventional radiotherapy (RT; n = 10), and (3) PLDR (n = 10). Tumor-bearing mice received 2 Gy daily dose for 2 consecutive days. Weekly magnetic resonance imaging was used for tumor growth monitoring. For study 2, 20 mice received 8 Gy total body irradiation either continuously (n = 10) or 40 × 0.2 Gy pulses with 3-minute intervals (n = 10). For study 1, both conventional RT and PLDR significantly inhibited the growth of A549 xenografts compared with the control group (>35% difference in the mean tumor volume; P < .05). The PLDR results were slightly better than conventional RT (8% difference in the mean tumor volume; P > .05). For study 2, the average weight was 20.94 ± 1.68 g and 25.69 ± 1.27 g and the survival time was 8 days and 12 days for mice treated with conventional RT and PLDR (P < .05), respectively. This study showed that PLDR could control A549 tumors as effectively as conventional RT, and PLDR induced much less normal tissue toxicity than conventional RT. Thus, PLDR would be a good modality for recurrent lung cancers. This article reports our results of an in vivo animal investigation of PLDR for the treatment of recurrent cancers, which may not be eligible for treatment because of the dose limitations on nearby healthy organs that have been irradiated in previous treatments. This was the first in vivo study to quantify the tumor control and normal tissue toxicities of PLDR using mice with implanted tumors, and our findings provided evidence to support the clinical trials that employ PLDR treatment techniques.

  15. SU-E-T-501: Normal Tissue Toxicities of Pulsed Low Dose Rate Radiotherapy and Conventional Radiotherapy: An in Vivo Total Body Irradiation Study

    SciTech Connect

    Cvetkovic, D; Zhang, P; Wang, B; Chen, L; Ma, C

    2014-06-01

    Purpose: Pulsed low dose rate radiotherapy (PLDR) is a re-irradiation technique for therapy of recurrent cancers. We have previously shown a significant difference in the weight and survival time between the mice treated with conventional radiotherapy (CRT) and PLDR using total body irradiation (TBI). The purpose of this study was to investigate the in vivo effects of PLDR on normal mouse tissues.Materials and Methods: Twenty two male BALB/c nude mice, 4 months of age, were randomly assigned into a PLDR group (n=10), a CRT group (n=10), and a non-irradiated control group (n=2). The Siemens Artiste accelerator with 6 MV photon beams was used. The mice received a total of 18Gy in 3 fractions with a 20day interval. The CRT group received the 6Gy dose continuously at a dose rate of 300 MU/min. The PLDR group was irradiated with 0.2Gyx20 pulses with a 3min interval between the pulses. The mice were weighed thrice weekly and sacrificed 2 weeks after the last treatment. Brain, heart, lung, liver, spleen, gastrointestinal, urinary and reproductive organs, and sternal bone marrow were removed, formalin-fixed, paraffin-embedded and stained with H and E. Morphological changes were observed under a microscope. Results: Histopathological examination revealed atrophy in several irradiated organs. The degree of atrophy was mild to moderate in the PLDR group, but severe in the CRT group. The most pronounced morphological abnormalities were in the immune and hematopoietic systems, namely spleen and bone marrow. Brain hemorrhage was seen in the CRT group, but not in the PLDR group. Conclusions: Our results showed that PLDR induced less toxicity in the normal mouse tissues than conventional radiotherapy for the same dose and regimen. Considering that PLDR produces equivalent tumor control as conventional radiotherapy, it would be a good modality for treatment of recurrent cancers.

  16. Implications of Gamma-Ray Transparency Constraints in Blazars: Minimum Distances and Gamma-Ray Collimation

    NASA Technical Reports Server (NTRS)

    Becker, Peter A.; Kafatos, Menas

    1995-01-01

    We develop a general expression for the gamma - gamma absorption coefficient, alpha(sub gamma(gamma)) for gamma-rays propagating in an arbitrary direction at an arbitrary point in space above an X-ray-emitting accretion disk. The X-ray intensity is assumed to vary as a power law in energy and radius between the outer disk radius, R(sub 0), and the inner radius, R(sub ms) which is the radius of marginal stability for a Schwarzschild black hole. We use our result for alpha(sub gamma(gamma)) to calculate the gamma - gamma optical depth, tau(sub gamma(gamma)) for gamma - rays created at height z and propagating at angle Phi relative to the disk axis, and we show that for Phi = 0 and z greater than or approx equal to R(sub 0), tau(sub gamma(gamma)) proportional to Epsilon(sup alpha)z(sup -2(alpha) - 3), where alpha is the X-ray spectral index and Epsilon is the gamma - ray energy. As an application, we use our formalism to compute the minimum distance between the central black hole and the site of production of the gamma-rays detected by EGRET during the 1991 June flare of 3C 279. In order to obtain an upper limit, we assume that all of the X-rays observed contemporaneously by Ginga were emitted by the disk. Our results suggest that the observed gamma - rays may have originated within less than or approx equal to 45 GM/sq c from a black hole of mass greater than or approx equal to 10(exp 9) solar mass, perhaps in active plasma located above the central funnel of the accretion disk. This raises the possibility of establishing a direct connection between the production of the observed gamma - rays and the accretion of material onto the black hole. We also consider the variation of the optical depth as a function of the angle of propagation Phi. Our results indicate that the "focusing" of the gamma - rays along the disk axis due to pair production is strong enough to explain the observed degree of alignment in blazar sources. If the gamma - rays are produced isotropically

  17. The solar gamma ray and neutron capabilities of COMPTEL on the Gamma Ray Observatory

    NASA Technical Reports Server (NTRS)

    Ryan, James M.; Lockwood, John A.

    1989-01-01

    The imaging Compton telescope COMPTEL on the Gamma Ray Observatory (GRO) has unusual spectroscopic capabilities for measuring solar gamma-ray and neutron emission. The launch of the GRO is scheduled for June 1990 near the peak of the sunspot cycle. With a 30 to 40 percent probability for the Sun being in the COMPTEL field-of-view during the sunlit part of an orbit, a large number of flares will be observed above the 800 keV gamma-ray threshold of the telescope. The telescope energy range extends to 30 MeV with high time resolution burst spectra available from 0.1 to 10 MeV. Strong Compton tail suppression of instrumental gamma-ray interactions will facilitate improved spectral analysis of solar flare emissions. In addition, the high signal to noise ratio for neutron detection and measurement will provide new neutron spectroscopic capabilities. Specifically, a flare similar to that of 3 June 1982 will provide spectroscopic data on greater than 1500 individual neutrons, enough to construct an unambiguous spectrum in the energy range of 20 to 200 MeV. Details of the instrument and its response to solar gamma-rays and neutrons will be presented.

  18. Fermi Gamma-ray Space Telescope Observations of Gamma-ray Pulsars

    NASA Astrophysics Data System (ADS)

    Saz Parkinson, P. M.

    2009-04-01

    The Large Area Telescope on the recently launched Fermi Gamma-ray Space Telescope (formerly GLAST), with its large field of view and effective area, combined with its excellent timing capabilities, is poised to revolutionize the field of gamma-ray astrophysics. The large improvement in sensitivity over EGRET is expected to result in the discovery of many new gamma-ray pulsars, which in turn should lead to fundamental advances in our understanding of pulsar physics and the role of neutron stars in the Galaxy. Almost immediately after launch, Fermi clearly detected all previously known gamma-ray pulsars and is producing high precision results on these. An extensive radio and X-ray timing campaign of known (primarily radio) pulsars is being carried out in order to facilitate the discovery of new gamma-ray pulsars. In addition, a highly efficient time-differencing technique is being used to conduct blind searches for radio-quiet pulsars, which has already resulted in new discoveries. I present some recent results from searches for pulsars carried out on Fermi data, both blind searches, and using contemporaneous timing of known radio pulsars.

  19. Discovery of gamma-ray pulsations from the transitional redback PSR J1227-4853

    SciTech Connect

    Johnson, Tyrel J.; Ray, Paul S.; Roy, Jayanta; Cheung, C. C.; Harding, A. K.; Pletsch, H. J.; Fort, S.; Camilo, F.; Deneva, J.; Bhattacharyya, B.; Stappers, B. W.; Kerr, M.

    2015-06-10

    Here, the 1.69 ms spin period of PSR J1227–4853 was recently discovered in radio observations of the low-mass X-ray binary XSS J12270–4859 following the announcement of a possible transition to a rotation-powered millisecond pulsar state, inferred from decreases in optical, X-ray, and gamma-ray flux from the source. We report the detection of significant (5σ) gamma-ray pulsations after the transition, at the known spin period, using ~1 year of data from the Large Area Telescope (LAT) on board the Fermi Gamma-ray Space Telescope. The gamma-ray light curve of PSR J1227–4853 can be fit by one broad peak, which occurs at nearly the same phase as the main peak in the 1.4 GHz radio profile. The partial alignment of light-curve peaks in different wavebands suggests that at least some of the radio emission may originate at high altitude in the pulsar magnetosphere, in extended regions co-located with the gamma-ray emission site. We folded the LAT data at the orbital period, both pre- and post-transition, but find no evidence for significant modulation of the gamma-ray flux. Analysis of the gamma-ray flux over the mission suggests an approximate transition time of 2012 November 30. Continued study of the pulsed emission and monitoring of PSR J1227–4853, and other known redback systems, for subsequent flux changes will increase our knowledge of the pulsar emission mechanism and transitioning systems.

  20. Discovery of gamma-ray pulsations from the transitional redback PSR J1227-4853

    DOE PAGES

    Johnson, Tyrel J.; Ray, Paul S.; Roy, Jayanta; ...

    2015-06-10

    Here, the 1.69 ms spin period of PSR J1227–4853 was recently discovered in radio observations of the low-mass X-ray binary XSS J12270–4859 following the announcement of a possible transition to a rotation-powered millisecond pulsar state, inferred from decreases in optical, X-ray, and gamma-ray flux from the source. We report the detection of significant (5σ) gamma-ray pulsations after the transition, at the known spin period, using ~1 year of data from the Large Area Telescope (LAT) on board the Fermi Gamma-ray Space Telescope. The gamma-ray light curve of PSR J1227–4853 can be fit by one broad peak, which occurs at nearlymore » the same phase as the main peak in the 1.4 GHz radio profile. The partial alignment of light-curve peaks in different wavebands suggests that at least some of the radio emission may originate at high altitude in the pulsar magnetosphere, in extended regions co-located with the gamma-ray emission site. We folded the LAT data at the orbital period, both pre- and post-transition, but find no evidence for significant modulation of the gamma-ray flux. Analysis of the gamma-ray flux over the mission suggests an approximate transition time of 2012 November 30. Continued study of the pulsed emission and monitoring of PSR J1227–4853, and other known redback systems, for subsequent flux changes will increase our knowledge of the pulsar emission mechanism and transitioning systems.« less

  1. DISCOVERY OF GAMMA-RAY PULSATIONS FROM THE TRANSITIONAL REDBACK PSR J1227-4853

    SciTech Connect

    Johnson, T. J.; Ray, P. S.; Cheung, C. C.; Roy, J.; Bhattacharyya, B.; Stappers, B. W.; Harding, A. K.; Pletsch, H. J.; Fort, S.; Camilo, F.; Deneva, J.; Kerr, M. E-mail: Paul.Ray@nrl.navy.mil

    2015-06-10

    The 1.69 ms spin period of PSR J1227−4853 was recently discovered in radio observations of the low-mass X-ray binary XSS J12270−4859 following the announcement of a possible transition to a rotation-powered millisecond pulsar state, inferred from decreases in optical, X-ray, and gamma-ray flux from the source. We report the detection of significant (5σ) gamma-ray pulsations after the transition, at the known spin period, using ∼1 year of data from the Large Area Telescope (LAT) on board the Fermi Gamma-ray Space Telescope. The gamma-ray light curve of PSR J1227−4853 can be fit by one broad peak, which occurs at nearly the same phase as the main peak in the 1.4 GHz radio profile. The partial alignment of light-curve peaks in different wavebands suggests that at least some of the radio emission may originate at high altitude in the pulsar magnetosphere, in extended regions co-located with the gamma-ray emission site. We folded the LAT data at the orbital period, both pre- and post-transition, but find no evidence for significant modulation of the gamma-ray flux. Analysis of the gamma-ray flux over the mission suggests an approximate transition time of 2012 November 30. Continued study of the pulsed emission and monitoring of PSR J1227−4853, and other known redback systems, for subsequent flux changes will increase our knowledge of the pulsar emission mechanism and transitioning systems.

  2. Multi-Messenger Time-Domain Astronomy with the Fermi Gamma-ray Burst Monitor

    NASA Astrophysics Data System (ADS)

    Connaughton, Valerie; Goldstein, Adam; Fermi GBM - LIGO Group

    2017-01-01

    With exciting new detections of gravitational waves by LIGO and astrophysical neutrinos by IceCube and ANTARES, the era of multi-messenger time-domain astronomy has arrived. The Fermi Gamma-ray Burst Monitor (GBM) continuously observes the entire sky that is not occulted by the Earth in gamma-rays from 8 keV - 40 MeV with 2 microsecond temporal resolution, with regular data downlinks every few hours. This wealth of near-realtime all-sky data has lead to the development of continuous data searches for gamma-ray events, such as Gamma-Ray Bursts (GRBs), in coincidence with astrophysical neutrinos and gravitational wave events. Additionally, GBM has the ability to localize triggered and untriggered transient events to a few-degree accuracy, rapidly disseminate the alerts and localization sky maps within tens of seconds, and there have been several successful follow-up attempts by wide-field optical telescopes, such as the Palomar Transient Factory, to catch the fading optical afterglow of GBM-triggered GRBs. We discuss the current applications and importance of Fermi GBM in leading multi-messenger time-domain astronomy in the gamma-ray regime.

  3. Diagnosing ICF gamma-ray physics

    SciTech Connect

    Herrmann, Hans W; Kim, Y H; Mc Evoy, A; Young, C S; Mack, J M; Hoffman, N; Wilson, D C; Langenbrunner, J R; Evans, S; Sedillo, T; Batha, S H; Dauffy, L; Stoeffl, W; Malone, R; Kaufman, M I; Cox, B C; Tunnel, T W; Miller, E K; Rubery, M

    2010-01-01

    Gamma rays produced in an ICF environment open up a host of physics opportunities we are just beginning to explore. A branch of the DT fusion reaction, with a branching ratio on the order of 2e-5 {gamma}/n, produces 16.7 MeV {gamma}-rays. These {gamma}-rays provide a direct measure of fusion reaction rate (unlike x-rays) without being compromised by Doppler spreading (unlike neutrons). Reaction-rate history measurements, such as nuclear bang time and burn width, are fundamental quantities that will be used to optimize ignition on the National Ignition Facility (NIF). Gas Cherenkov Detectors (GCD) that convert fusion {gamma}-rays to UV/visible Cherenkov photons for collection by fast optical recording systems established their usefulness in illuminating ICF physics in several experimental campaigns at OMEGA. Demonstrated absolute timing calibrations allow bang time measurements with accuracy better than 30 ps. System impulse response better than 95 ps fwhm have been made possible by the combination of low temporal dispersion GCDs, ultra-fast microchannel-plate photomultiplier tubes (PMT), and high-bandwidth Mach Zehnder fiber optic data links and digitizers, resulting in burn width measurement accuracy better than 10ps. Inherent variable energy-thresholding capability allows use of GCDs as {gamma}-ray spectrometers to explore other interesting nuclear processes. Recent measurements of the 4.44 MeV {sup 12}C(n,n{prime}) {gamma}-rays produced as 14.1 MeV DT fusion neutrons pass through plastic capsules is paving the way for a new CH ablator areal density measurement. Insertion of various neutron target materials near target chamber center (TCC) producing secondary, neutron-induced {gamma}y-rays are being used to study other nuclear interactions and as in-situ sources to calibrate detector response and DT branching ratio. NIF Gamma Reaction History (GRH) diagnostics, based on the GCD concept, are now being developed based on optimization of sensitivity, bandwidth

  4. Timing the Geminga Pulsar with Gamma-Ray Observations

    NASA Technical Reports Server (NTRS)

    Mattox, J. R.; Halpern, Jules P.; Caraveo, P. A.; Oliversen, Ronald (Technical Monitor)

    2001-01-01

    We present the COS-B/EGRET 1997 ephemeris for the rotation of the Geminga pulsar. This ephemeris is derived from high-energy gamma-ray observations that span 24 yr. The recently obtained accurate position and proper motion are assumed. A cubic ephemeris predicts the rotational phase of Geminga with errors smaller than 50 milliperiods for all existing high-energy gamma-ray observations that span a 24.2 yr timing baseline. The braking index obtained is 17 +/- 1. Further observation is required to ascertain whether this high value truly reflects the rotational energy loss mechanism, or whether it is a manifestation of timing noise. The ephemeris parameters are sufficiently constrained so that timing noise will be the limitation on forward extrapolation. If Geminga continues to rotate without a glitch, as it has for at least 23 yr, we expect this ephemeris to continue to describe the phase, with an error of less than 100 milliperiods, until 2008. Statistically significant timing residuals are detected in the EGRET data that depart from the cubic ephemeris at a level of 30 milliperiods. Although this could simply be an additional manifestation of timing noise, the EGRET timing residuals appear to have a sinusoidal modulation that is consistent with a planet of mass 1.7/sin i solar mass, orbiting Geminga at a radius of 3.3 AU.

  5. Timing the Geminga Pulsar with Gamma-Ray Observations

    NASA Technical Reports Server (NTRS)

    Mattox, J. R.; Halpern, Jules P.; Caraveo, P. A.; Oliversen, Ronald (Technical Monitor)

    2001-01-01

    We present the COS-B/EGRET 1997 ephemeris for the rotation of the Geminga pulsar. This ephemeris is derived from high-energy gamma-ray observations that span 24 yr. The recently obtained accurate position and proper motion are assumed. A cubic ephemeris predicts the rotational phase of Geminga with errors smaller than 50 milliperiods for all existing high-energy gamma-ray observations that span a 24.2 yr timing baseline. The braking index obtained is 17 +/- 1. Further observation is required to ascertain whether this high value truly reflects the rotational energy loss mechanism, or whether it is a manifestation of timing noise. The ephemeris parameters are sufficiently constrained so that timing noise will be the limitation on forward extrapolation. If Geminga continues to rotate without a glitch, as it has for at least 23 yr, we expect this ephemeris to continue to describe the phase, with an error of less than 100 milliperiods, until 2008. Statistically significant timing residuals are detected in the EGRET data that depart from the cubic ephemeris at a level of 30 milliperiods. Although this could simply be an additional manifestation of timing noise, the EGRET timing residuals appear to have a sinusoidal modulation that is consistent with a planet of mass 1.7/sin i solar mass, orbiting Geminga at a radius of 3.3 AU.

  6. Interpretations and implications of gamma-ray lines from solar flares, the galactic centre and gamma-ray transients

    NASA Technical Reports Server (NTRS)

    Ramaty, R.; Lingenfelter, R. E.

    1981-01-01

    Gamma-ray line emission from the Sun results from the nuclear interactions of energetic protons and nuclei with the solar atmosphere. These interactions produce gamma-ray lines from neutron capture, positron annihilation, and nuclear deexcitation. Observation of such gamma-rays can provide unique information on high energy processes at the Sun. Details of solar gamma-ray spectroscopy are discussed along with the galactic center 0.511 MeV line. The richness of astronomy at 0.511 MeV is indicated by the great variety of astrophysical positron production mechanisms and by the many astrophysical sites where such mechanisms could operate. Attention is also given to lines from gamma-ray transients, and the prospects for gamma-ray line detections, taking into account gamma-ray lines from processes of nucleosynthesis and lines from low-energy cosmic ray interactions.

  7. CdZnTe gamma ray spectrometer for orbital gamma ray spectroscopy.

    SciTech Connect

    Prettyman, T. H.; Feldman, W. C.; Fuller, K. R.; Storms, S. A.; Soldner, S. A.; Lawrence, David J. ,; Browne, M. C.; Moss, C. E.

    2001-01-01

    We present the design and analysis of a new gamma ray spectrometer for planetary science that uses an array of CdZnTe detectors to achieve the detection efficiency needed for orbital measurements. The use of CdZnTe will provide significantly improved pulse height resolution relative to scintillation-based detectors, with commensurate improvement in the accuracy of elemental abundances determined by gamma ray and neutron spectroscopy. The spectrometer can be flown either on the instrument deck of the spacecraft or on a boom. For deck-mounted systems, a BGO anticoincidence shield is included in the design to suppress the response of the CdZnTe detector to gamma rays that originate in the spacecraft. The BGO shield also serves as a backup spectrometer, providing heritage from earlier planetary science missions and reducing the risk associated with the implementation of new technology.

  8. Near-infrared and gamma-ray monitoring of TANAMI gamma-ray bright sources

    SciTech Connect

    Nesci, R.; Tosti, G.; Pursimo, T.; Ojha, R.; Kadler, M.

    2013-06-18

    Context. We present that spectral energy distribution and its variability are basic tools for understanding the physical processes operating in active galactic nuclei (AGN). Aims. In this paper we report the results of a one-year near-infrared (NIR) and optical monitoring of a sample of 22 AGN known to be gamma-ray emitters, aimed at discovering correlations between optical and gamma-ray emission. Methods. We observed our objects with the Rapid Eye Mount (REM) telescope in J,H,K, and R bands nearly twice every month during their visibility window and derived light curves and spectral indexes. We also analyzed the gamma-ray data from the Fermi gamma-ray Space Telescope, making weekly averages. Results. Six sources were never detected during our monitoring, proving to be fainter than their historical Two micron all sky survey (2MASS) level. All of the sixteen detected sources showed marked flux density variability, while the spectral indexes remained unchanged within our sensitivity limits. Steeper sources showed, on average, a larger variability. From the NIR light curves we also computed a variability speed index for each detected source. Only one source (PKS 0208-512) underwent an NIR flare during our monitoring. Half of the sources showed a regular flux density trend on a one-year time scale, but do not show any other peculiar characteristic. The broadband spectral index αro appears to be a good proxy of the NIR spectral index only for BL Lac objects. No clear correlation between NIR and gamma-ray data is evident in our data, save for PKS 0537-441, PKS 0521-360, PKS 2155-304, and PKS 1424-418. In conclusion, the gamma-ray/NIR flux ratio showed a large spread, QSO being generally gamma-louder than BL Lac, with a marked correlation with the estimated peak frequency (νpeak) of the synchrotron emission.

  9. Near-infrared and gamma-ray monitoring of TANAMI gamma-ray bright sources

    DOE PAGES

    Nesci, R.; Tosti, G.; Pursimo, T.; ...

    2013-06-18

    Context. We present that spectral energy distribution and its variability are basic tools for understanding the physical processes operating in active galactic nuclei (AGN). Aims. In this paper we report the results of a one-year near-infrared (NIR) and optical monitoring of a sample of 22 AGN known to be gamma-ray emitters, aimed at discovering correlations between optical and gamma-ray emission. Methods. We observed our objects with the Rapid Eye Mount (REM) telescope in J,H,K, and R bands nearly twice every month during their visibility window and derived light curves and spectral indexes. We also analyzed the gamma-ray data from themore » Fermi gamma-ray Space Telescope, making weekly averages. Results. Six sources were never detected during our monitoring, proving to be fainter than their historical Two micron all sky survey (2MASS) level. All of the sixteen detected sources showed marked flux density variability, while the spectral indexes remained unchanged within our sensitivity limits. Steeper sources showed, on average, a larger variability. From the NIR light curves we also computed a variability speed index for each detected source. Only one source (PKS 0208-512) underwent an NIR flare during our monitoring. Half of the sources showed a regular flux density trend on a one-year time scale, but do not show any other peculiar characteristic. The broadband spectral index αro appears to be a good proxy of the NIR spectral index only for BL Lac objects. No clear correlation between NIR and gamma-ray data is evident in our data, save for PKS 0537-441, PKS 0521-360, PKS 2155-304, and PKS 1424-418. In conclusion, the gamma-ray/NIR flux ratio showed a large spread, QSO being generally gamma-louder than BL Lac, with a marked correlation with the estimated peak frequency (νpeak) of the synchrotron emission.« less

  10. New stage in high-energy gamma-ray studies with GAMMA-400 after Fermi-LAT

    NASA Astrophysics Data System (ADS)

    Topchiev, N. P.; Galper, A. M.; Bonvicini, V.; Adriani, O.; Arkhangelskaja, I. V.; Arkhangelskiy, A. I.; Bakaldin, A. V.; Bobkov, S. G.; Boezio, M.; Dalkarov, O. D.; Egorov, A. E.; Gorbunov, M. S.; Gusakov, Yu. V.; Hnatyk, B. I.; Kadilin, V. V.; Kaplin, V. A.; Kheymits, M. D.; Korepanov, V. E.; Leonov, A. A.; Longo, F.; Mikhailov, V. V.; Mocchiutti, E.; Moiseev, A. A.; Moskalenko, I. V.; Naumov, P. Yu.; Picozza, P.; Runtso, M. F.; Serdin, O. V.; Sparvoli, R.; Spillantini, P.; Stozhkov, Yu. I.; Suchkov, S. I.; Taraskin, A. A.; Tavani, M.; Yurkin, Yu. T.; Zverev, V. G.

    2017-06-01

    Fermi-LAT has made a significant contribution to the study of high-energy gamma-ray diffuse emission and the observations of 3000 discrete sources. However, one third of all gamma-ray sources (both galactic and extragalactic) are unidentified, the data on the diffuse gamma-ray emission should be clarified, and signatures of dark matter particles in the high-energy gamma-ray range are not observed up to now. GAMMA-400, the currently developing gamma-ray telescope, will have angular (˜0.01∘ at 100 GeV) and energy (˜1% at 100 GeV) resolutions in the energy range of 10-1000 GeV which are better than Fermi-LAT (as well as ground gamma-ray telescopes) by a factor of 5-10. It will observe some regions of the Universe (such as the Galactic Center, Fermi Bubbles, Crab, Cygnus, etc.) in a highly elliptic orbit (without shading the telescope by the Earth) continuously for a long time. It will allow us to identify many discrete sources, to clarify the structure of extended sources, to specify the data on the diffuse emission, and to resolve gamma rays from dark matter particles.

  11. Future Prospects for Space-Based Gamma Ray Astronomy

    NASA Astrophysics Data System (ADS)

    McConnell, Mark

    2016-03-01

    The gamma-ray sky offers a unique view into broad range of high energy astrophysical phenomena, from nearby solar flares, to galactic pulsars, to gamma-ray bursts at the furthest reaches of the Universe. In recent years, results from the Fermi mission have further demonstrated the broad range of topics that can be addressed by gamma-ray observations. The full range of gamma-ray energies is quite broad, from about 100 keV up to about 100 TeV. The energy range below several hundred GeV is the domain of space-based gamma-ray observatories, a range that is not completely covered by the Fermi LAT instrument. The gamma ray community has embarked on an effort to define the next steps for space-based gamma ray astronomy. These discussions are being facilitated through the Gamma-ray Science Interest Group (GammaSIG), which exists to provide community input to NASA in regards to current and future needs of the gamma-ray astrophysics community. Through a series of workshops and symposia, the GammaSIG is working to bring the community together with one common vision, a vision that will be expressed in the form of a community roadmap. This talk will summarize some of the latest results from active gamma ray observatories and will summarize the status of the community roadmap effort.

  12. The connection between the 15 GHz radio and gamma-ray emission in blazars

    NASA Astrophysics Data System (ADS)

    Max-Moerbeck, W.; Richards, J. L.; Hovatta, T.; Pavlidou, V.; Pearson, T. J.; Readhead, A. C. S.; King, O. G.; Reeves, R.

    2015-03-01

    Since mid-2007 we have carried out a dedicated long-term monitoring programme at 15 GHz using the Owens Valley Radio Observatory 40 meter telescope (OVRO 40m). One of the main goals of this programme is to study the relation between the radio and gamma-ray emission in blazars and to use it as a tool to locate the site of high energy emission. Using this large sample of objects we are able to characterize the radio variability, and study the significance of correlations between the radio and gamma-ray bands. We find that the radio variability of many sources can be described using a simple power law power spectral density, and that when taking into account the red-noise characteristics of the light curves, cases with significant correlation are rare. We note that while significant correlations are found in few individual objects, radio variations are most often delayed with respect to the gamma-ray variations. This suggests that the gamma-ray emission originates upstream of the radio emission. Because strong flares in most known gamma-ray-loud blazars are infrequent, longer light curves are required to settle the issue of the strength of radio-gamma cross-correlations and establish confidently possible delays between the two. For this reason continuous multiwavelength monitoring over a longer time period is essential for statistical tests of jet emission models.

  13. A New Background Rejection Technique for the Milagro Gamma-Ray Detector

    NASA Astrophysics Data System (ADS)

    Abdo, A. A.

    Milagro is a TeV gamma-ray detector that utilizes a large water Cherenkov detector to observe extensive air showers produced by high energy particles impacting the Earth's atmosphere. Milagro's distinct advantage compared to other TeV gamma-ray detectors is that it views a wide field (2 steradian over-head sky) and it continuously operates (>90% live time). A new background rejection technique that significantly increases the sensitivity of the Milagro detector has been developed. This technique improves the sensitivity of the Milagro detector by more than a factro of 2 over the previous technique (Atkins et al. 2003). This new /newtechnique differentiates between hadronic and gamma-ray showers by looking at the fundamental differences in the shower parameters between these two types of showers and how they register in the detector. These shower parameters include the number of Muons presented in the EAS, the size of the EAS, and some shower reconstruction parameters. This technique resulted in discoveries of localized TeV gamma-ray sources from the Galactic plane. Details of the new technique along with an all-sky TeV gamma-ray map --using this technique-- will be presented.

  14. Intense Gamma-Ray Flashes Above Thunderstorms on the Earth and Other Planets

    NASA Technical Reports Server (NTRS)

    Fishman, Gerald J.

    2010-01-01

    Intense millisecond flashes of MeV photons have been observed with space-borne detectors in Earth orbit. They are expected to be present on other planets that exhibit lightning. The terrestrial gamma-ray flashes (TGFs) were discovered with the Burst and Transient Source Experiment (BATSE) aboard the Compton Gamma-Ray Observatory (CGRO) in the early 1990s. They are now being observed with several other instruments, including the Gamma-ray Burst Monitor (GBM) detectors on the Fermi Gamma-ray Space Telescope. Although Fermi- GBM was designed and optimized for the observation of cosmic gamma-ray bursts (GRBs), it has unprecedented capabilities for TGF observations. The TGFs usually have extremely hard continuous spectra, typical of highly- Comptonized bremsstrahlung radiation. These spectral are harder than those of GRBs, with photons extending to over 40 MeV. The most likely origin of these high-energy photons is bremsstrahlung radiation produced by a relativistic "runaway avalanche" electron beam. Such a beam is expected to be produced in an extended, intense electric field in or above thunderstorm regions. The altitude of origin and beaming characteristics of the radiation are quite uncertain. They have generated considerable observational and theoretical interest in recent years. This talk will give an overview of the all of the space-borne observations of TGFs that have been made thus far. Instruments are being designed specifically for TGF observations from new spacecraft as well as from airborne platforms

  15. Space-Borne Observations of Intense Gamma-Ray Flashes (TGFs) Above Thunderstorms

    NASA Technical Reports Server (NTRS)

    Fishman, Gerald J.

    2010-01-01

    Intense millisecond flashes of MeV photons are being observed with space-borne detectors. These terrestrial gamma-ray flashes (TGFs) were discovered with the Burst and Transient Source Experiment (BATSE) aboard the Compton Gamma-Ray Observatory (CGRO) in the early 1990s. They are now being observed with several other instruments, including the Gamma-ray Burst Monitor (GBM) detectors on the Fermi Gamma-ray Space Telescope. Although Fermi-GBM was designed and optimized for the observation of cosmic gamma-ray bursts (GRBs), it has unprecedented capabilities for TGF observations. The TGFs usually have extremely hard continuous spectra, typical of highly-Comptonized bremsstrahlung radiation. These spectral are harder than those of GRBs, with photons extending to over 40 MeV. The most likely origin of these high-energy photons is bremsstrahlung radiation produced by a relativistic runaway avalanche electron beam. Such a beam is expected to be produced in an extended, intense electric field in or above thunderstorm regions. The altitude of origin and beaming characteristics of the radiation are quite uncertain. These TGFs may produce an appreciable radiation dose to passengers and crew in nearby aircraft. They have generated considerable observational and theoretical interest in recent years. Instruments are being designed specifically for TGF observations from new spacecraft as well as from airborne platforms.

  16. Intense Gamma-Ray Flashes Above Thunderstorms on the Earth and Other Planets

    NASA Technical Reports Server (NTRS)

    Fishman, Gerald J.

    2010-01-01

    Intense millisecond flashes of MeV photons have been observed with space-borne detectors in Earth orbit. They are expected to be present on other planets that exhibit lightning. The terrestrial gamma-ray flashes (TGFs) were discovered with the Burst and Transient Source Experiment (BATSE) aboard the Compton Gamma-Ray Observatory (CGRO) in the early 1990s. They are now being observed with several other instruments, including the Gamma-ray Burst Monitor (GBM) detectors on the Fermi Gamma-ray Space Telescope. Although Fermi- GBM was designed and optimized for the observation of cosmic gamma-ray bursts (GRBs), it has unprecedented capabilities for TGF observations. The TGFs usually have extremely hard continuous spectra, typical of highly- Comptonized bremsstrahlung radiation. These spectral are harder than those of GRBs, with photons extending to over 40 MeV. The most likely origin of these high-energy photons is bremsstrahlung radiation produced by a relativistic "runaway avalanche" electron beam. Such a beam is expected to be produced in an extended, intense electric field in or above thunderstorm regions. The altitude of origin and beaming characteristics of the radiation are quite uncertain. They have generated considerable observational and theoretical interest in recent years. This talk will give an overview of the all of the space-borne observations of TGFs that have been made thus far. Instruments are being designed specifically for TGF observations from new spacecraft as well as from airborne platforms

  17. Gamma ray burst outflows and afterglows

    NASA Astrophysics Data System (ADS)

    Morsony, Brian J.

    2008-08-01

    We carry out a theoretical investigation of jet propagation in Gamma Ray Bursts and examine the jitter radiation mechanism as a means of producing prompt and afterglow emission. We study the long-term evolution of relativistic jets in collapsars and examine the effects of viewing angle on the subsequent gamma ray bursts. Our simulations allow us to single out three phases in the jet evolution: a precursor phase in which relativistic material turbulently shed from the head of the jet first emerges from the star; a shocked jet phase where a fully shocked jet of material is emerging; and an unshocked jet phase where the jet consists of a free-streaming, unshocked core surrounded by a thin boundary layer of shocked jet material. We also carry out a series of simulations with central engines that vary on long time periods comparable to the breakout time of the jet, on short time periods (0.1s) much less than the breakout time, and finally that decay as a power law at late times. We conclude that rapid variability seen in prompt GRB emission, as well as shallow decays and flares seen in the X-ray afterglow, can be caused by central engine variability. Finally, we present a detailed computation of the jitter radiation spectrum, including self-absorption, for electrons inside Weibel-like shock- generated magnetic fields. We apply our results to the case of the prompt and afterglow emission of gamma-ray bursts. We conclude that jitter and synchrotron afterglows can be distinguished from each other with good quality observations. However, it is unlikely that the difference can explain the peculiar behavior of several recent observations, such as flat X-ray slopes and uncorrelated optical and X-ray behavior.

  18. Gamma Ray Bursts: an Enigma Being Unraveled

    SciTech Connect

    De Rujula, Alvaro

    2003-05-14

    The best astrophysical accelerators are quasars and the 'progenitors' of GRBs which, after decades of observations and scores of theories, we still do not understand. But, I shall argue, we now know quite well where GRBs come from, and we understand how their 'beams' behave, as they make short pulses of gamma rays and long-duration X-ray, optical and radio 'afterglows'. I shall argue that our understanding of these phenomena, based on the 'Cannonball Model', is unusually simple, precise and successful. The 'sociology' of GRBs is interesting per se and, in this sense, the avatars of the Cannonball Model in confronting the generally accepted 'fireball models' are also quite revealing.

  19. Gamma ray emission and solar flares

    NASA Technical Reports Server (NTRS)

    Lin, R. P.; Ramaty, R.

    1978-01-01

    Solar gamma ray line and continuum emission provide information about particle acceleration and its temporal behavior; the energy spectrum, composition and directivity of the accelerated particles; and the composition, density and temperatures of the ambient medium. These data, coupled with the comprehensive photon and particle observations available for the sun, give a detailed picture of the particle acceleration and flare energy release processes. Additional information on elemental and isotopic abundances, surface nuclear reactions and coronal heating mechanisms can be obtained. Implications of present observations and the potential return from future observational are discussed.

  20. Multiwavelength Studies of gamma-ray Binaries

    NASA Astrophysics Data System (ADS)

    Aragona, Christina

    2011-01-01

    High mass X-ray binaries (HMXBs) consist of an O or B star orbited by either a neutron star or a black hole. Of the 114 known Galactic HMXBs, a handful of these objects, dubbed gamma-ray binaries, have been observed to produce MeV-TeV emission. The very high energy emission can be produced either by accretion from the stellar wind onto a black hole or a collision between the stellar wind and a relativistic pulsar wind. Both these scenarios make gamma-ray binaries valuable nearby systems for studying the physics of shocks and jets. Currently, the nature of the compact object and the high energy production mechanism is unknown or unconfirmed in over half of these systems. My goal for this dissertation is to constrain the parameters describing two of these systems: LS 5039 and HD 259440. LS 5039 exhibits gamma-ray emission modulated with its orbital period. The system consists of an ON6.5V((f)) star and an unidentified compact companion. Using optical spectra from the CTIO 1.5m telescope, we found LS 5039 to have an orbital period of 3.90608 d and an eccentricity of 0.337. Spectra of the Halpha line observed with SOAR indicate a mass loss rate of ˜ 1.9x10 -8 M yr-1. Observations taken with ATCA at 13 cm, 6 cm, and 3 cm indicate radio fluxes between 10--40 mJy. The measurements show variability with time, indicating a source other than thermal emission from the stellar wind. HD 259440 is a B0pe star that was proposed as the optical counterpart to the gamma-ray source HESS J0632+057. Using optical spectra from the KPNO CF, KPNO 2.1m, and OHP telescopes, we find a best fit stellar effective temperature of 27500--30000 K, a log surface gravity of 3.75--4.0, a mass of 13.2--19.0 Msolar, and a radius of 6.0--9.6 Rsolar. By fitting the spectral energy distribution, we find a distance between 1.1--1.7 kpc. We do not detect any significant radial velocity shifts in our data, ruling out orbital periods shorter than one month. If HD 259440 is a binary, it is likely a long

  1. Gamma ray bursts from extragalactic sources

    NASA Technical Reports Server (NTRS)

    Hoyle, Fred; Burbidge, Geoffrey

    1992-01-01

    The properties of gamma ray bursts of classical type are found to be explicable in terms of high speed collisions between stars. A model is proposed in which the frequency of such collisions can be calculated. The model is then applied to the nuclei of galaxies in general on the basis that galaxies, or at least some fraction of them, originate in the expulsion of stars from creation centers. Evidence that low level activity of this kind is also taking place at the center of our own Galaxy is discussed. The implications for galactic evolution are discussed and a negative view of black holes is taken.

  2. Very high energy gamma ray astrophysics

    NASA Astrophysics Data System (ADS)

    Lamb, R. C.

    1983-03-01

    Sources of very high energy gamma rays (E(BETA) (11) eV) and improvement of the instrumentation of detectors in this energy regime were investigated. Approximately 4 x 10(5) Cerepkov air shower events from the region of Cygnus X-3 and the Crab nebula were collected with the JPL instrumentation during the fall of 1982. Significant improvement on the 1981 sensitivity to source variations and the development of a Cerenkov air shower camera are reported. A suitable mirror and mount for use as a detector auxiliary to the primary 10 inch Mt. Hopkins detector is located.

  3. THE ORTHOGONAL GAMMA-RAY BURST MODEL

    SciTech Connect

    Contopoulos, Ioannis; Pugliese, Daniela; Nathanail, Antonios

    2014-01-01

    We explore the analogy between a rotating magnetized black hole and an axisymmetric pulsar and derive the black hole's electromagnetic spindown after its formation in the core collapse of a supermassive star. The spindown shows two characteristic phases: an early Blandford-Znajek phase that lasts a few hundred seconds and a late pulsar-like afterglow phase that lasts much longer. During the first phase, the spindown luminosity decreases almost exponentially, whereas during the afterglow phase it decreases as t {sup –a} with 1 ≲ a ≲ 1.5. We associate our findings with long duration gamma-ray bursts and compare them with observations.

  4. Gamma-ray burster counterparts - Radio

    NASA Technical Reports Server (NTRS)

    Schaefer, Bradley E.; Cline, Thomas L.; Desai, U. D.; Teegarden, B. J.; Atteia, J.-L.; Barat, C.; Estulin, I. V.; Evans, W. D.; Fenimore, E. E.; Hurley, K.

    1989-01-01

    Many observers and theorists have suggested that gamma-ray bursters (GRBs) are related to highly magnetized rotating, neutron stars, in which case an analogy with pulsars implies that GRBs would be prodigious emitters of polarized radio emission during quiescence. The paper reports on a survey conducted with the Very Large Array radio telescope of 10 small GRB error regions for quiescent radio emission at wavelengths of 2, 6, and 20 cm. The sensitivity of the survey varied from 0.1 to 0.8 mJy. The observations did indeed reveal four radio sources inside the GRB error regions.

  5. Polarized gamma-rays with laser-Compton backscattering

    SciTech Connect

    Ohgaki, H.; Noguchi, T.; Sugiyama, S.

    1995-12-31

    Polarized gamma-rays were generated through laser-Compton backscattering (LCS) of a conventional Nd:YAG laser with electrons circulating in the electron storage ring TERAS at Electrotechnical Laboratory. We measured the energy, the energy spread, and the yield of the gamma-rays to characterize our gamma-ray source. The gamma-ray energy can be varied by changing the energy of the electrons circulating the storage ring. In our case, the energy of electrons in the storage ring were varied its energy from 200 to 750 MeV. Consequently, we observed gamma-ray energies of 1 to 10 MeV with 1064 run laser photons. Furthermore, the gamma-ray energy was extended to 20 MeV by using the 2nd harmonic of the Nd:YAG laser. This shows a good agreement with theoretical calculation. The gamma-ray energy spread was also measured to be 1% FWHM for -1 MeV gamma-rays and to be 4% FWHM for 10 MeV gamma-rays with a narrow collimator that defined the scattering cone. The gamma-ray yield was 47.2 photons/mA/W/s. This value is consistent with a rough estimation of 59.5 photons/mA/W/s derived from theory. Furthermore, we tried to use these gamma-rays for a nuclear fluorescence experiment. If we use a polarized laser beam, we can easily obtain polarized gamma-rays. Elastically scattered photons from {sup 208} Pb were clearly measured with the linearly polarized gamma-rays, and we could assign the parity of J=1 states in the nucleus. We should emphasize that the polarized gamma-ray from LCS is quit useful in this field, because we can use highly, almost completely, polarized gamma-rays. We also use the LCS gamma-rays to measure the photon absorption coefficients. In near future, we will try to generate a circular polarized gamma-ray. We also have a plan to use an FEL, because it can produce intense laser photons in the same geometric configuration as the LCS facility.

  6. Gamma-Ray Pulsar Light Curves as Probes of Magnetospheric Structure

    NASA Technical Reports Server (NTRS)

    Harding, A. K.

    2016-01-01

    The large number of gamma-ray pulsars discovered by the Fermi Gamma-Ray Space Telescope since its launch in 2008 dwarfs the handful that were previously known. The variety of observed light curves makes possible a tomography of both the ensemble-averaged field structure and the high-energy emission regions of a pulsar magnetosphere. Fitting the gamma-ray pulsar light curves with model magnetospheres and emission models has revealed that most of the high-energy emission, and the particles acceleration, takes place near or beyond the light cylinder, near the current sheet. As pulsar magnetosphere models become more sophisticated, it is possible to probe magnetic field structure and emission that are self-consistently determined. Light curve modeling will continue to be a powerful tool for constraining the pulsar magnetosphere physics.

  7. Time resolved photoluminescence from a phosphate glass (GD-300) irradiated with heavy ions and gamma rays.

    PubMed

    Yasuda, Hiroshi; Ishidoya, Tatsuyo

    2003-03-01

    The time-resolved photoluminescence from a phosphate-glass photoluminescence dosimeter (GD-300) was compared for different quality radiations: relativistic heavy ions (12C and 40Ar) and 60Co gamma rays. The intensities of photoluminescence afterglow at 2-7 micro(s) after pulsed UV excitation, i.e., in the time range used for conventional dosimetry, soon reached stable conditions for all radiations. Whereas the early photoluminescence emission at the range less than 0.4 micro(s) was notably unstable for gamma rays only; it continued decreasing even at 2 d after irradiation. In contrast, the photoluminescence afterglows for the heavy ions were stable over the whole range after excitation. These results indicate that the process of photoluminescence-center formation is different for heavy ions and gamma rays.

  8. Neutron-induced 2.2 MeV background in gamma ray telescopes

    NASA Technical Reports Server (NTRS)

    Zanrosso, E. M.; Long, J. L.; Zych, A. D.; White, R. S.

    1985-01-01

    Neutron-induced gamma ray production is an important source of background in Compton scatter gamma ray telescopes where organic scintillator material is used. Most important is deuteron formation when atmospheric albedo and locally produced neutrons are thermalized and subsequently absorbed in the hydrogenous material. The resulting 2.2 MeV gamma ray line radiation essentially represents a continuous isotropic source within the scintillator itself. Interestingly, using a scintillator material with a high hydrogen-to-carbon ratio to minimize the scintillator material with a high hydrogen-to-carbon ratio to minimize the neutron-induced 4.4 MeV carbon line favors the np reaction. The full problem of neutron-induced background in Compton scatter telescopes has been previously discussed. Results are presented of observations with the University of California balloon-borne Compton scatter telescope where the 2.2 MeV induced line emission is prominently seen.

  9. Fermi Gamma-Ray Space Telescope - Science Highlights for the First Two Years on Orbit

    NASA Technical Reports Server (NTRS)

    Moiseev, Alexander

    2011-01-01

    Fermi science objectives cover probably everything in high energy astrophysics: How do super massive black holes in Active Galactic Nuclei create powerful jets of material moving at nearly light speed? What are the jets made of? What are the mechanisms that produce Gamma-Ray Burst (GRB) explosions? What is the energy budget? How does the Sun generate high-energy gamma-rays in flares? How do the pulsars operate? How many of them are around and how different are they? What are the unidentified gamma-ray sources found by EGRET? What is the origin of the cosmic rays that pervade the Galaxy? What is the nature of dark matter? Fermi LAT successfully operates on the orbit for more than 2 years and demonstrates excellent performance, which is continuously monitored and calibrated. LAT collected> 100 billion on-orbit triggers

  10. A model of the gamma-ray background on the BATSE experiment.

    NASA Astrophysics Data System (ADS)

    Rubin, B. C.; Lei, F.; Fishman, G. J.; Finger, M. H.; Harmon, B. A.; Kouveliotou, C.; Paciesas, W. S.; Pendleton, G. N.; Wilson, R. B.; Zhang, S. N.

    1996-12-01

    The BATSE experiment on the Compton Gamma-Ray Observatory is a nearly uninterrupted all-sky monitor in the hard X-ray/gamma-ray energy range. Count rate data continuously transmitted to the ground from Low Earth Orbit (altitude ~450km) is dominated, in the 20-300keV energy range, by diffuse cosmic background modulated by blocking effects of the Earth. Other background sources include atmospheric gamma-rays and the decay of radionuclides created in cosmic ray and radiation belt trapped particle interactions with the detector. Numerous discrete cosmic sources are also present in these data. In this paper we describe a semi-empirical background model which has been used to reduce the effect of dominant background sources. The use of this model can increase the sensitivity of the experiment to sources observed with the Earth occultation technique; to long period pulsed sources; to analysis of flickering noise; and to transient events.

  11. TeVCat: An online catalog for Very High Energy Gamma-Ray Astronomy

    NASA Astrophysics Data System (ADS)

    Wakely, S. P.; Horan, D.

    An overview of TeVCat, a new online interactive catalog for very high energy (VHE; E > 50 GeV) gamma-ray astronomy is presented. As VHE astronomy continues to grow, the usefulness of a one-stop clearing house for information on new sources is increasingly evident. TeVCat is intended to be such a resource. With sky maps, source information, visibility plotters and linked references, it will help the wider gamma-ray community stay up-to-date and informed on this exciting and rapidly developing field.

  12. Results from GROCSE I: A real-time search for gamma ray burst optical counterparts

    SciTech Connect

    Lee, B.; Akerlof, C.; Ables, E.

    1995-10-27

    The GROCSE I experiment (Gamma-Ray Optical Counterpart Search Experiment) is a rapid slewing wide field of view optical telescope at Lawrence Livermore National Laboratory which responds to triggers from the BATSE GRB data telemetry stream that have been processed and distributed by the BACODINE network. GROCSE 1 has been in continuous automated operation since January 1994. As of October 1995, sky images for 22 GRB triggers have been recorded, in some cases while the burst was still emitting gamma rays. The preliminary analysis of eight of these events are presented here. No optical counterparts have yet been detected. Limits for optical emission are given.

  13. Gamma-ray Output Spectra from 239 Pu Fission

    DOE PAGES

    Ullmann, John

    2015-05-25

    The gamma-ray multiplicities, individual gamma-ray energy spectra, and total gamma energy spectra following neutron-induced fission of 239Pu were measured using the DANCE detector at Los Alamos. Corrections for detector response were made using a forward-modeling technique based on propagating sets of gamma rays generated from a paramaterized model through a GEANT model of the DANCE array and adjusting the parameters for best fit to the measured spectra. The results for the gamma-ray spectrum and multiplicity are in general agreement with previous results, but the measured total gamma-ray energy is about 10% higher. We found that a dependence of the gamma-raymore » spectrum on the gamma-ray multplicity was also observed. Finally, global model calculations of the multiplicity and gamma energy distributions are in good agreement with the data, but predict a slightly softer total-energy distribution.« less

  14. Fermi gamma-ray imaging of a radio galaxy.

    PubMed

    Abdo, A A; Ackermann, M; Ajello, M; Atwood, W B; Baldini, L; Ballet, J; Barbiellini, G; Bastieri, D; Baughman, B M; Bechtol, K; Bellazzini, R; Berenji, B; Blandford, R D; Bloom, E D; Bonamente, E; Borgland, A W; Bregeon, J; Brez, A; Brigida, M; Bruel, P; Burnett, T H; Buson, S; Caliandro, G A; Cameron, R A; Caraveo, P A; Casandjian, J M; Cavazzuti, E; Cecchi, C; Celik, O; Chekhtman, A; Cheung, C C; Chiang, J; Ciprini, S; Claus, R; Cohen-Tanugi, J; Colafrancesco, S; Cominsky, L R; Conrad, J; Costamante, L; Cutini, S; Davis, D S; Dermer, C D; de Angelis, A; de Palma, F; Digel, S W; do Couto e Silva, E; Drell, P S; Dubois, R; Dumora, D; Farnier, C; Favuzzi, C; Fegan, S J; Finke, J; Focke, W B; Fortin, P; Fukazawa, Y; Funk, S; Fusco, P; Gargano, F; Gasparrini, D; Gehrels, N; Georganopoulos, M; Germani, S; Giebels, B; Giglietto, N; Giordano, F; Giroletti, M; Glanzman, T; Godfrey, G; Grenier, I A; Grove, J E; Guillemot, L; Guiriec, S; Hanabata, Y; Harding, A K; Hayashida, M; Hays, E; Hughes, R E; Jackson, M S; Jóhannesson, G; Johnson, A S; Johnson, T J; Johnson, W N; Kamae, T; Katagiri, H; Kataoka, J; Kawai, N; Kerr, M; Knödlseder, J; Kocian, M L; Kuss, M; Lande, J; Latronico, L; Lemoine-Goumard, M; Longo, F; Loparco, F; Lott, B; Lovellette, M N; Lubrano, P; Madejski, G M; Makeev, A; Mazziotta, M N; McConville, W; McEnery, J E; Meurer, C; Michelson, P F; Mitthumsiri, W; Mizuno, T; Moiseev, A A; Monte, C; Monzani, M E; Morselli, A; Moskalenko, I V; Murgia, S; Nolan, P L; Norris, J P; Nuss, E; Ohsugi, T; Omodei, N; Orlando, E; Ormes, J F; Paneque, D; Parent, D; Pelassa, V; Pepe, M; Pesce-Rollins, M; Piron, F; Porter, T A; Rainò, S; Rando, R; Razzano, M; Razzaque, S; Reimer, A; Reimer, O; Reposeur, T; Ritz, S; Rochester, L S; Rodriguez, A Y; Romani, R W; Roth, M; Ryde, F; Sadrozinski, H F-W; Sambruna, R; Sanchez, D; Sander, A; Saz Parkinson, P M; Scargle, J D; Sgrò, C; Siskind, E J; Smith, D A; Smith, P D; Spandre, G; Spinelli, P; Starck, J-L; Stawarz, Ł; Strickman, M S; Suson, D J; Tajima, H; Takahashi, H; Takahashi, T; Tanaka, T; Thayer, J B; Thayer, J G; Thompson, D J; Tibaldo, L; Torres, D F; Tosti, G; Tramacere, A; Uchiyama, Y; Usher, T L; Vasileiou, V; Vilchez, N; Vitale, V; Waite, A P; Wallace, E; Wang, P; Winer, B L; Wood, K S; Ylinen, T; Ziegler, M; Hardcastle, M J; Kazanas, D

    2010-05-07

    The Fermi Gamma-ray Space Telescope has detected the gamma-ray glow emanating from the giant radio lobes of the radio galaxy Centaurus A. The resolved gamma-ray image shows the lobes clearly separated from the central active source. In contrast to all other active galaxies detected so far in high-energy gamma-rays, the lobe flux constitutes a considerable portion (greater than one-half) of the total source emission. The gamma-ray emission from the lobes is interpreted as inverse Compton-scattered relic radiation from the cosmic microwave background, with additional contribution at higher energies from the infrared-to-optical extragalactic background light. These measurements provide gamma-ray constraints on the magnetic field and particle energy content in radio galaxy lobes, as well as a promising method to probe the cosmic relic photon fields.

  15. Highlights of GeV Gamma-Ray Astronomy

    NASA Technical Reports Server (NTRS)

    Thompson, David J.

    2010-01-01

    Because high-energy gamma rays are primarily produced by high-energy particle interactions, the gamma-ray survey of the sky by the Fermi Gamma-ray Space Telescope offers a view of sites of cosmic ray production and interactions. Gamma-ray bursts, pulsars, pulsar wind nebulae, binary sources, and Active Galactic Nuclei are all phenomena that reveal particle acceleration through their gamma-ray emission. Diffuse Galactic gamma radiation, Solar System gamma-ray sources, and energetic radiation from supernova remnants are likely tracers of high-energy particle interactions with matter and photon fields. This paper will present a broad overview of the constantly changing sky seen with the Large Area Telescope (LAT) on the Fermi spacecraft.

  16. SAS-2 galactic gamma ray results. 2. Localized sources

    NASA Technical Reports Server (NTRS)

    Hartman, R. C.; Fichtel, C. E.; Kniffen, D. A.; Lamb, R. C.; Thompson, D. J.; Bignami, G. F.; Oegelman, H.; Oezel, M. E.; Tuemer, T.

    1976-01-01

    Gamma-ray emission was detected from the radio pulsars PSR1818-04 and PSR1747-46, in addition to the previously reported gamma-ray emission from the Crab and Vela pulsars. Since the Crab pulsar is the only one observed in the optical and X-ray bands, these gamma-ray observations suggest a uniquely gamma-ray phenomenon occurring in a fraction of the radio pulsars. Using distance estimates it is found that PSR1818-04 has a gamma-ray luminosity comparable to that of the Crab pulsar, while the luminosities of PSR1747-46 and the Vela pulsar are approximately an order of magnitude lower. This survey of SAS-2 data for pulsar correlations has also yielded upper limits to gamma-ray luminosity for 71 other radio pulsars.

  17. The Animated Gamma-ray Sky Revealed by the Fermi Gamma-ray Space Telescope

    ScienceCinema

    Isabelle Grenier

    2016-07-12

    The Fermi Gamma-ray Space Telescope has been observing the sky in gamma-rays since August 2008.  In addition to breakthrough capabilities in energy coverage (20 MeV-300 GeV) and angular resolution, the wide field of view of the Large Area Telescope enables observations of 20% of the sky at any instant, and of the whole sky every three hours. It has revealed a very animated sky with bright gamma-ray bursts flashing and vanishing in minutes, powerful active galactic nuclei flaring over hours and days, many pulsars twinkling in the Milky Way, and X-ray binaries shimmering along their orbit. Most of these variable sources had not been seen by the Fermi predecessor, EGRET, and the wealth of new data already brings important clues to the origin of the high-energy emission and particles powered by the compact objects. The telescope also brings crisp images of the bright gamma-ray emission produced by cosmic-ray interactions in the interstellar medium, thus allowing to measure the cosmic nuclei and electron spectra across the Galaxy, to weigh interstellar clouds, in particular in the dark-gas phase. The telescope sensitivity at high energy will soon provide useful constraints on dark-matter annihilations in a variety of environments. I will review the current results and future prospects of the Fermi mission.

  18. The Animated Gamma-ray Sky Revealed by the Fermi Gamma-ray Space Telescope

    SciTech Connect

    Isabelle Grenier

    2009-04-01

    The Fermi Gamma-ray Space Telescope has been observing the sky in gamma-rays since August 2008.  In addition to breakthrough capabilities in energy coverage (20 MeV-300 GeV) and angular resolution, the wide field of view of the Large Area Telescope enables observations of 20% of the sky at any instant, and of the whole sky every three hours. It has revealed a very animated sky with bright gamma-ray bursts flashing and vanishing in minutes, powerful active galactic nuclei flaring over hours and days, many pulsars twinkling in the Milky Way, and X-ray binaries shimmering along their orbit. Most of these variable sources had not been seen by the Fermi predecessor, EGRET, and the wealth of new data already brings important clues to the origin of the high-energy emission and particles powered by the compact objects. The telescope also brings crisp images of the bright gamma-ray emission produced by cosmic-ray interactions in the interstellar medium, thus allowing to measure the cosmic nuclei and electron spectra across the Galaxy, to weigh interstellar clouds, in particular in the dark-gas phase. The telescope sensitivity at high energy will soon provide useful constraints on dark-matter annihilations in a variety of environments. I will review the current results and future prospects of the Fermi mission.

  19. The Animated Gamma-ray Sky Revealed by the Fermi Gamma-ray Space Telescope

    SciTech Connect

    Grenier, Isabelle

    2009-04-01

    The Fermi Gamma-ray Space Telescope has been observing the sky in gamma-rays since August 2008. In addition to breakthrough capabilities in energy coverage (20 MeV-300 GeV) and angular resolution, the wide field of view of the Large Area Telescope enables observations of 20% of the sky at any instant, and of the whole sky every three hours. It has revealed a very animated sky with bright gamma-ray bursts flashing and vanishing in minutes, powerful active galactic nuclei flaring over hours and days, many pulsars twinkling in the Milky Way, and X-ray binaries shimmering along their orbit. Most of these variable sources had not been seen by the Fermi predecessor, EGRET, and the wealth of new data already brings important clues to the origin of the high-energy emission and particles powered by the compact objects. The telescope also brings crisp images of the bright gamma-ray emission produced by cosmic-ray interactions in the interstellar medium, thus allowing to measure the cosmic nuclei and electron spectra across the Galaxy, to weigh interstellar clouds, in particular in the dark-gas phase. The telescope sensitivity at high energy will soon provide useful constraints on dark-matter annihilations in a variety of environments. I will review the current results and future prospects of the Fermi mission.

  20. Gamma-ray Polarimetry with the All-sky Medium Energy Gamma-ray Observatory (AMEGO)

    NASA Astrophysics Data System (ADS)

    Kislat, Fabian

    2017-08-01

    The All-sky Medium Energy Gamma-ray Observatory (AMEGO) is a next-generation Compton and pair-production telescope. It will allow us to perform sensitive polarimetric observations in the 200keV to 3MeV energy range. Due to its wide field of view it will survey the entire sky every 3 hours, enabling polarization measurements not only of persistent, but also of transient sources such as gamma-ray bursts. The polarization of gamma-rays carries geometric information about compact emission regions that are too small to be imaged at any wavelength, and will thus provide qualitatively new insights. In this paper we discuss AMEGO's polarization sensitivity based on detailed simulations of the instrument. We will use these results to discuss the scientific potential of AMEGO to search for violations of Lorentz invariance. Finally, we present predictions for possible observations based on theoretical models of bright gamma-ray bursts, blazar jets, and the high-energy tail of the galactic black hole binary Cygnus X-1. These predictions will demonstrate AMEGO's ability to distinguish different theoretical models.

  1. Extended Gamma-Ray Emission from Large Coronal Loops

    NASA Astrophysics Data System (ADS)

    Rank, G.; Debrunner, H.; Lockwood, J.; McConnell, M.; Ryan, J.; Schonfelder, V.

    In June 1991 the Sun produced a series of six X-class flares which were the most powerful events of the last solar cycle. All of them originated from the same active region NOAA 6659. Target-of-opportunity observations with CGRO yielded a wealth of data from hard X-rays to gamma-rays and additionally direct neutron measurements by COMPTEL. We have analyzed COMPTEL gamma-ray data and have compared them with the results from other instruments. The most remarkable finding from the June 1991 flares was the observation of prolonged gamma-ray emission. For all three flares high-energetic emission was measured by a number of instruments and lasted for several hours after the impulsive phase. The following table shows the observational coverage of the flares by high-energy instruments: || HXR || 2.2 MeV || 4--7 (1st hour) || > 50 MeV June 9 || BATSE || COMPTEL || COMPTEL || June 11 || BATSE || COMPTEL || COMPTEL || EGRET June 15 || BATSE || COMPTEL || || GAMMA-1 An early model by Ramaty & Mandzhavidze (1994) explained the extended emission as long-term trapping of accelerated particles in magnetic loops. The model was calculated to explain EGRET data of the 11 June 1991 flare. An important prediction from trapping models is the hardening of the spectrum of the trapped particles with time. We have compared time profiles of different parts of the gamma-ray spectrum, originating from particles with different energies, to test this prediction (Rank et al. 1996). We have used 2.2 MeV and 4--7 MeV data from COMPTEL, and for later times the 2.2 MeV flux from COMPTEL and the >50 MeV flux from EGRET and GAMMA-1, respectively. These observational results show that the shape of the proton spectrum does not change significantly during the extended phase, and thus contradict a scenario of trapped particles that would suffer energy-dependent energy losses. Other explanations, the continuous acceleration of particles throughout the extended phase in large, turbulent, magnetic loops (Ryan

  2. Fermi GBM Observations of Terrestrial Gamma-Ray Flashes

    NASA Technical Reports Server (NTRS)

    Wilson-Hodge, Colleen A.; Briggs, M. S.; Connaughton, V.; Fishman, G. J.; Bhat, P. N.; Paciesas, W. S.; Preece, R.; Kippen, R. M.; vonKienlin, A.; Dwyer, J. R.; hide

    2010-01-01

    This slide presentation explores the relationship between Terrestrial Gamma-Ray Flashes (TGF) and lightning. Using data from the World-Wide Lightning Location Network (WWLLN), and the gamma ray observations from Fermi's Gamma-ray Burst Monitor (GBM), the study reviews any causal relationship between TGFs and lightning. The conclusion of the study is that the TGF and lightning are simultaneous with out a causal relationship.

  3. Gamma Ray/neutron Spectrometers for Planetary Elemental Mapping

    NASA Technical Reports Server (NTRS)

    Reedy, R. C.; Auchampaugh, G. F.; Barraclough, B. L.; Burt, W. W.; Byrd, R. C.; Drake, D. M.; Edwards, B. C.; Feldman, W. C.; Martin, R. A.; Moss, C. E.

    1993-01-01

    Los Alamos has designed gamma ray and neutron spectrometers for Lunar Scout, two robotic missions to map the Moon from 100 km polar orbits. Knowledge of the elemental composition is desirable in identifying resources and for geochemical studies and can be obtained using gamma ray and neutron spectrometers. Measurements with gamma ray and neutron spectrometers complement each other in determining elemental abundances in a planet's surface. Various aspects of the instruments are discussed.

  4. Interpretation of the pulsed gamma ray emission from Vela

    NASA Technical Reports Server (NTRS)

    Thompson, D. J.

    1975-01-01

    A model is proposed for the Vela pulsar in which the radio emission originates near the surface of the neutron star while the pulsed gamma ray emission is produced by synchrotron radiation near the speed of light cylinder. This model can explain the energy flux, double pulse structure, and phase shift with respect to the radio of the gamma ray emission and offers approximate quantitative predictions for other X-ray and gamma-ray fluxes.

  5. Interpretation of the pulsed gamma-ray emission from Vela

    NASA Technical Reports Server (NTRS)

    Thompson, D. J.

    1975-01-01

    A model is proposed for the Vela pulsar in which the radio emission originates near the surface of the neutron star while the pulsed gamma-ray emission is produced by synchrotron radiation near the speed-of-light cylinder. This model can explain the energy flux, double pulse structure, and phase shift (with respect to the radio) of the gamma-ray emission, and offers approximate quantitative predictions for other X- and gamma-ray fluxes.

  6. A Gamma-Ray Camera for Inspection Control

    SciTech Connect

    Danilenko, K.N.; Ignatyev, G.N.; Semenov, D.S; D Chernov, M.Y.; Morgan, J.

    2000-06-29

    The Research Institute of Pulse Technique has constructed a gamma-ray camera for imaging radioactive materials. The work was performed under the DOE Lab to Lab Dismantlement Transparency Program with the Lawrence Livermore National Laboratory (USA). The gamma-ray camera was intended for imaging radioactive materials, including fissile materials, in a storage container. In this case, the spatial resolution established in the specifications for the gamma ray camera was limited for reasons of inspection non-intrusiveness.

  7. Flooded member detection by gamma ray technique

    SciTech Connect

    Spencer, J.

    1995-12-31

    Following API`s recommended procedures (Draft 17) for the assessment of existing platforms, inspection personnel and platform maintenance engineers need to determine the structural safety and physical integrity of the platform. To perform testing of a platform`s subsea supports, there is now a tool that allows evaluation on short notice without extensive member preparation. The expansion of topside facilities can be undertaken with confidence, and the sale or purchase of the platform is enhanced when proof of the structural integrity is presented. With advances in the use of nucleonics, flooded member testing and evaluation is performed in 5 seconds, successfully and economically. Gamma Ray Flooded Member Detection performed by qualified Tracerco personnel is approved by Lloyds Register for recertification in the North Sea area and is widely used. With today`s emphasis on safe long term use of existing facilities, this easy, proven method of inspection should be the forefront of options available. This paper presents the theory and practical aspects of the use of Gamma Ray radiation to test submerged pipes, legs or structural supports.

  8. Gamma ray tests of Minimal Dark Matter

    SciTech Connect

    Cirelli, Marco; Sala, Filippo; Taoso, Marco; Hambye, Thomas; Panci, Paolo E-mail: thambye@ulb.ac.be E-mail: filippo.sala@cea.fr

    2015-10-01

    We reconsider the model of Minimal Dark Matter (a fermionic, hypercharge-less quintuplet of the EW interactions) and compute its gamma ray signatures. We compare them with a number of gamma ray probes: the galactic halo diffuse measurements, the galactic center line searches and recent dwarf galaxies observations. We find that the original minimal model, whose mass is fixed at 9.4 TeV by the relic abundance requirement, is constrained by the line searches from the Galactic Center: it is ruled out if the Milky Way possesses a cuspy profile such as NFW but it is still allowed if it has a cored one. Observations of dwarf spheroidal galaxies are also relevant (in particular searches for lines), and ongoing astrophysical progresses on these systems have the potential to eventually rule out the model. We also explore a wider mass range, which applies to the case in which the relic abundance requirement is relaxed. Most of our results can be safely extended to the larger class of multi-TeV WIMP DM annihilating into massive gauge bosons.

  9. Environments of Gamma-Ray Bursts

    NASA Astrophysics Data System (ADS)

    Roming, Peter; Tobler, Jennifer

    2016-01-01

    The death of some of the most massive stars are manifest as long gamma-ray bursts (GRBs). Studying their light curves and spectra are uncovering some of the properties of the "central engine" that remains after the progenitor star collapses, as well as the environment in which they reside. Much of our current understanding comes from data obtained in the gamma-ray to X-ray. Despite this progress in the high-energy regime, our understanding of the soft-energy component (UV/optical) is lacking, particularly with regards to UV/optical flaring from the central engine and distinguishing between interstellar material and wind environments. Although these questions have been addressed for individual bursts, no systematic study in the UV/optical has been done due to the lack of a large homogenous sample. The Swift Ultra-Violet/Optical Telescope (UVOT) has observed more GRBs in the UV/optical than any other telescope. From these observations we have generated a homogenous UV/optical GRB afterglow catalog. From this catalog and coupled with archival Swift X-Ray Telescope (XRT) data, we examine the spectral evolution of GRBs in order to probe the circumburst environment and to test current progenitor models.

  10. Gamma ray tests of Minimal Dark Matter

    SciTech Connect

    Cirelli, Marco; Hambye, Thomas; Panci, Paolo; Sala, Filippo; Taoso, Marco

    2015-10-12

    We reconsider the model of Minimal Dark Matter (a fermionic, hypercharge-less quintuplet of the EW interactions) and compute its gamma ray signatures. We compare them with a number of gamma ray probes: the galactic halo diffuse measurements, the galactic center line searches and recent dwarf galaxies observations. We find that the original minimal model, whose mass is fixed at 9.4 TeV by the relic abundance requirement, is constrained by the line searches from the Galactic Center: it is ruled out if the Milky Way possesses a cuspy profile such as NFW but it is still allowed if it has a cored one. Observations of dwarf spheroidal galaxies are also relevant (in particular searches for lines), and ongoing astrophysical progresses on these systems have the potential to eventually rule out the model. We also explore a wider mass range, which applies to the case in which the relic abundance requirement is relaxed. Most of our results can be safely extended to the larger class of multi-TeV WIMP DM annihilating into massive gauge bosons.

  11. Gamma-Ray Bursts and Cosmology

    NASA Technical Reports Server (NTRS)

    Norris, Jay P.

    2003-01-01

    The unrivalled, extreme luminosities of gamma-ray bursts (GRBs) make them the favored beacons for sampling the high redshift Universe. To employ GRBs to study the cosmic terrain -- e.g., star and galaxy formation history -- GRB luminosities must be calibrated, and the luminosity function versus redshift must be measured or inferred. Several nascent relationships between gamma-ray temporal or spectral indicators and luminosity or total energy have been reported. These measures promise to further our understanding of GRBs once the connections between the luminosity indicators and GRB jets and emission mechanisms are better elucidated. The current distribution of 33 redshifts determined from host galaxies and afterglows peaks near z $\\sim$ 1, whereas for the full BATSE sample of long bursts, the lag-luminosity relation predicts a broad peak z $\\sim$ 1--4 with a tail to z $\\sim$ 20, in rough agreement with theoretical models based on star formation considerations. For some GRB subclasses and apparently related phenomena -- short bursts, long-lag bursts, and X-ray flashes -- the present information on their redshift distributions is sparse or entirely lacking, and progress is expected in Swift era when prompt alerts become numerous.

  12. IS CALVERA A GAMMA-RAY PULSAR?

    SciTech Connect

    Halpern, J. P.

    2011-07-20

    Originally selected as a neutron star (NS) candidate in the ROSAT All-Sky Survey, 1RXS J141256.0+792204 ('Calvera') was discovered to be a 59 ms X-ray pulsar in a pair of XMM-Newton observations by Zane et al. Surprisingly, their claimed detection of this pulsar in Fermi {gamma}-ray data requires no period derivative, severely restricting its dipole magnetic field strength, spin-down luminosity, and distance to small values. This implies that the cooling age of Calvera is much younger than its characteristic spin-down age. If so, it could be a mildly recycled pulsar, or the first 'orphaned' central compact object (CCO). Here we show that the published Fermi ephemeris fails to align the pulse phases of the two X-ray observations with each other, which indicates that the Fermi detection is almost certainly spurious. Analysis of additional Fermi data also does not confirm the {gamma}-ray detection. This leaves the spin-down rate of Calvera less constrained, and its place among the families of NSs uncertain. It could still be either an ordinary pulsar, a mildly recycled pulsar, or an orphaned CCO.

  13. Physics of Gamma Ray Burst Sources

    NASA Technical Reports Server (NTRS)

    Meszaros, Peter

    2004-01-01

    During this grant period, the physics of gamma-ray bursts was investigated. A number of new results have emerged. The importance of pair formation in high compactness burst spectra may help explain x-ray flashes; a universal jet shape is a likely explanation for the distribution of jet break times; gravitational waves may be copiously produced both in short bursts from compact mergers and in long bursts arising from collapsars; x-ray iron lines are likely to be due to interaction with the stellar atmosphere of the progenitor; prompt optical flashes from reverse shocks will give diagnostics on the Lorentz factor and the environment; GeV and TeV emission from bursts may be expected in the external shock; etc. The group working with the PI included postdocs Dr. Bing Zhang (now assistant professor at University of Nevada); Dr. Shiho Kobayashi; graduate student Lijun Gou; collaborators Drs. Tim Kallman and Martin Rees. Meszaros shared with Rees and Dr. Bohan Paczynsky the AAS Rossi Prize in 2000 for their work on the theory of gamma ray bursts. The refereed publications and conference proceedings resulting from this research are summarized below. The PI gave a number of invited talks at major conferences, also listed.

  14. Physics of Gamma Ray Burst Sources

    NASA Technical Reports Server (NTRS)

    Meszaros, Peter

    2004-01-01

    During this grant period, the physics of gamma-ray bursts was investigated. A number of new results have emerged. The importance of pair formation in high compactness burst spectra may help explain x-ray flashes; a universal jet shape is a likely explanation for the distribution of jet break times; gravitational waves may be copiously produced both in short bursts from compact mergers and in long bursts arising from collapsars; x-ray iron lines are likely to be due to interaction with the stellar atmosphere of the progenitor; prompt optical flashes from reverse shocks will give diagnostics on the Lorentz factor and the environment; GeV and TeV emission from bursts may be expected in the external shock; etc. The group working with the PI included postdocs Dr. Bing Zhang (now assistant professor at University of Nevada); Dr. Shiho Kobayashi; graduate student Lijun Gou; collaborators Drs. Tim Kallman and Martin Rees. Meszaros shared with Rees and Dr. Bohan Paczynsky the AAS Rossi Prize in 2000 for their work on the theory of gamma ray bursts. The refereed publications and conference proceedings resulting from this research are summarized below. The PI gave a number of invited talks at major conferences, also listed.

  15. Gamma-Ray Bursts: Characteristics and Prospects

    NASA Astrophysics Data System (ADS)

    Azzam, W. J.; Zitouni, H.; Guessoum, N.

    2017-06-01

    Gamma-ray bursts (GRBs) are the most powerful explosions in the universe. They have remained the object of intense research ever since their discovery was declassified in the early 1970s. Several space-borne missions have been dedicated to their study, including the Compton Gamma-Ray Burst Observatory (CGRO) in the 1990s and the current Swift and Fermi satellites. However, despite several decades of focused research, the precise mechanisms behind these enigmatic explosions have not been fully established. In the first part of this paper, we review what is currently known about GRBs. This includes: GRB light-curves and spectra; the different progenitor models, i.e., the "collapsar" and "merger" models; and the afterglow characteristics, including external shocks and the surrounding medium. In the second part of the paper, we present our work, which focuses on utilizing GRBs as cosmological probes. GRBs are ideal cosmological tools, because they have been observed to great distances (redshifts up to z = 9.4) and their radiation is unencumbered by any intervening dust. Although GRBs are not standard candles, the discovery of several energy and luminosity correlations, like the Amati relation which correlates the intrinsic spectral peak energy, Ep,i to the equivalent isotropic energy, Eiso , has ushered in a new era in which GRBs are used to investigate cosmological issues like the star formation rate and the value of the matter-density parameter, ΩM.

  16. Iron K Lines from Gamma Ray Bursts

    NASA Technical Reports Server (NTRS)

    Kallman, T. R.; Meszaros, P.; Rees, M. J.

    2003-01-01

    We present models for reprocessing of an intense flux of X-rays and gamma rays expected in the vicinity of gamma ray burst sources. We consider the transfer and reprocessing of the energetic photons into observable features in the X-ray band, notably the K lines of iron. Our models are based on the assumption that the gas is sufficiently dense to allow the microphysical processes to be in a steady state, thus allowing efficient line emission with modest reprocessing mass and elemental abundances ranging from solar to moderately enriched. We show that the reprocessing is enhanced by down-Comptonization of photons whose energy would otherwise be too high to absorb on iron, and that pair production can have an effect on enhancing the line production. Both "distant" reprocessors such as supernova or wind remnants and "nearby" reprocessors such as outer stellar envelopes can reproduce the observed line fluxes with Fe abundances 30-100 times above solar, depending on the incidence angle. The high incidence angles required arise naturally only in nearby models, which for plausible values can reach Fe line to continuum ratios close to the reported values.

  17. Research in cosmic and gamma ray astrophysics: Cosmic physics portion

    NASA Technical Reports Server (NTRS)

    Stone, Edward C.; Mewaldt, Richard A.; Schindler, Stephen

    1993-01-01

    Research in particle astrophysics at the Space Radiation Laboratory (SRL) of the California Institute of Technology is supported under NASA Grant NAGW-1919. A three-year proposal for continuation of support was submitted a year ago and put into effect 1 October 1992. This report is the combined progress report and continuation application called for under the Federal Demonstration Project. Gamma-ray Astrophysics at SRL is separately supported under NAGW-1919 and will be separately summarized and proposed. This report will document progress and plans for our particle spectroscopy activities and for related data analysis, calibration, and community service activities. A bibliography and a budget will be attached as appendices. The Caltech SRL research program includes a heavy emphasis on elemental and isotopic spectroscopy of energetic particles in the cosmic radiation; in solar, interplanetary, and anomalous 'cosmic' radiation; and in planetary magnetospheres as discussed.

  18. The Role of Beam Geometry in Population Statistics and Pulse Profiles of Radio and Gamma-ray Pulsars

    NASA Technical Reports Server (NTRS)

    Gonthier, Peter L.; VanGuilder, Robert; Harding, Alice K.

    2004-01-01

    We present results of a pulsar population synthesis study that incorporates a number of recent developments and some significant improvements over our previous study. We have included the results of the Parkes multi-beam pulsar survey in our select group of nine radio surveys, doubling our sample of radio pulsars. More realistic geometries for the radio and gamma-ray beams are included in our Monte Carlo computer code that simulates the characteristics of the Galactic population of radio and gamma-ray pulsars. We adopted with some modifications the radio beam geometry of Arzoumanian, Chernoff & Cordes (2002). For the gamma-ray beam, we have assumed the slot gap geometry described in the work of Muslimov & Harding (2003). To account for the shape of the distribution of radio pulsars in the P(dot) - P diagram, we continue to find that decay of the magnetic field on a timescale of 2.8 Myr is needed. With all nine surveys, our model predicts that EGRET should have seen 7 radio-quiet (below the sensitivity of these radio surveys) and 19 radio-loud gamma-ray pulsars. AGILE (nominal sensitivity map) is expected to detect 13 radio-quiet and 37 radio-loud gamma-ray pulsars, while GLAST, with greater sensitivity is expected to detect 276 radio-quiet and 344 radio-loud gamma-ray pulsars. When the Parkes multi-beam pulsar survey is excluded, the ratio of radio-loud to radio-quiet gamma-ray pulsars decreases, especially for GLAST. The decrease for EGRET is 45%, implying that some fraction of EGRET unidentified sources are radio-loud gamma-ray pulsars. In the radio geometry adopted, short period pulsars are core dominated. Unlike the EGRET gamma-ray pulsars, our model predicts that when two gamma-ray peaks appear in the pulse profile, a dominant radio core peak appears in between the gamma-ray peaks. Our findings suggest that further improvements are required in describing both the radio and gamma-ray geometries.

  19. Gamma ray constraints on the galactic supernova rate

    NASA Technical Reports Server (NTRS)

    Hartmann, D.; The, L.-S.; Clayton, D. D.; Leising, M.; Mathews, G.; Woosley, S. E.

    1992-01-01

    Monte Carlo simulations of the expected gamma-ray signatures of galactic supernovae of all types are performed in order to estimate the significance of the lack of a gamma-ray signal due to supernovae occurring during the last millenium. Using recent estimates of nuclear yields, we determine galactic supernova rates consistent with the historic supernova record and the gamma-ray limits. Another objective of these calculations of galactic supernova histories is their application to surveys of diffuse galactic gamma-ray line emission.

  20. The gamma ray spectrometer for the Solar Maximum Mission

    NASA Technical Reports Server (NTRS)

    Forrest, D. J.; Chupp, E. L.; Ryan, J. M.; Cherry, M. L.; Gleske, I. U.; Reppin, C.; Pinkau, K.; Rieger, E.; Kanbach, G.; Kinzer, R. L.

    1980-01-01

    The paper describes an actively shielded, multicrystal scintillation spectrometer for measurement of the solar gamma ray flux used by the Solar Maximum Mission Gamma Ray Experiment. The instrument provides a 476-channel pulse height spectrum every 16.38 s over the 0.3-9 MeV energy range; the gamma ray spectral analysis can be extended to at least 15 MeV on command. The instrument is designed to measure the intensity, energy, and Doppler shift of narrow gamma ray lines, the intensity of extremely broadened lines, and the photon continuum.