Development of a high-specific-speed centrifugal compressor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rodgers, C.

1997-07-01

This paper describes the development of a subscale single-stage centrifugal compressor with a dimensionless specific speed (Ns) of 1.8, originally designed for full-size application as a high volume flow, low pressure ratio, gas booster compressor. The specific stage is noteworthy in that it provides a benchmark representing the performance potential of very high-specific-speed compressors, of which limited information is found in the open literature. Stage and component test performance characteristics are presented together with traverse results at the impeller exit. Traverse test results were compared with recent CFD computational predictions for an exploratory analytical calibration of a very high-specific-speed impellermore » geometry. The tested subscale (0.583) compressor essentially satisfied design performance expectations with an overall stage efficiency of 74% including, excessive exit casing losses. It was estimated that stage efficiency could be increased to 81% with exit casing losses halved.« less

30 CFR 57.8520 - Ventilation plan.

Code of Federal Regulations, 2014 CFR

2014-07-01

... depots, oil fuel storage depots, hoist rooms, compressors, battery charging stations and explosive... and booster fans including manufacturer's name, type, size, fan speed, blade setting, approximate... sketches showing how ventilation is accomplished in each typical type of working place including the...

30 CFR 57.8520 - Ventilation plan.

Code of Federal Regulations, 2011 CFR

2011-07-01

... depots, oil fuel storage depots, hoist rooms, compressors, battery charging stations and explosive... and booster fans including manufacturer's name, type, size, fan speed, blade setting, approximate... sketches showing how ventilation is accomplished in each typical type of working place including the...

30 CFR 57.8520 - Ventilation plan.

Code of Federal Regulations, 2012 CFR

2012-07-01

... depots, oil fuel storage depots, hoist rooms, compressors, battery charging stations and explosive... and booster fans including manufacturer's name, type, size, fan speed, blade setting, approximate... sketches showing how ventilation is accomplished in each typical type of working place including the...

30 CFR 57.8520 - Ventilation plan.

Code of Federal Regulations, 2013 CFR

2013-07-01

... depots, oil fuel storage depots, hoist rooms, compressors, battery charging stations and explosive... and booster fans including manufacturer's name, type, size, fan speed, blade setting, approximate... sketches showing how ventilation is accomplished in each typical type of working place including the...

77 FR 42719 - Alliance Pipeline, L.P.; Notice of Availability of the Environmental Assessment for the Proposed...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-20

... existing Alliance mainline in Renville County; One pig \\1\\ launcher at the proposed compressor station site and one pig receiver at the pressure regulating station site; and \\1\\ A ``pig'' is a tool that is...

78 FR 6749 - Airworthiness Directives; Rolls-Royce plc Turbofan Engines

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-31

... Airworthiness Directives; Rolls-Royce plc Turbofan Engines AGENCY: Federal Aviation Administration (FAA), DOT... (AD) for all Rolls-Royce plc (RR) models RB211 Trent 768-60, 772-60, and 772B-60 turbofan engines... 772B-60 turbofan engines. (d) Reason This AD was prompted by low-pressure (LP) compressor blade partial...

77 FR 26216 - Airworthiness Directives; Rolls-Royce plc Turbofan Engines

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-03

... Turbofan Engines AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed rulemaking..., RB211- Trent 892-17, RB211-Trent 892B-17, and RB211-Trent 895-17 turbofan engines. The existing AD...-Trent 895-17 turbofan engines. That AD requires initial and repetitive UIs of certain LP compressor...

78 FR 53749 - Gulf South Pipeline Company, LP, Petal Gas Storage, LLC; Notice of Availability of the...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-30

... (Moss Point Compressor Station); A new meter and regulator station and pig\\1\\ launcher/ receiver... Transmission Company, LLC's existing pipeline; and \\1\\ A ``pig'' is a tool that is inserted into and moves.... Associated appurtenant aboveground facilities along the proposed pipeline including mainline valves, pig...

76 FR 2605 - Airworthiness Directives; Rolls-Royce plc RB211-Trent 800 Series Turbofan Engines

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-14

... blade root lubrication coating system may be reduced dependant on the extent of previous running with... Trent 895 powered Boeing 777-200 aircraft experienced release of a low pressure (LP) compressor blade which failed due to fatigue cracking in the root section of the blade. The released blade (undercut root...

76 FR 24798 - Airworthiness Directives; Rolls-Royce plc (RR) RB211-Trent 875-17, RB211-Trent 877-17, RB211...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-03

... blade root lubrication coating system may be reduced dependant on the extent of previous running with... Trent 895 powered Boeing 777-200 aircraft experienced release of a low pressure (LP) compressor blade which failed due to fatigue cracking in the root section of the blade. The released blade (undercut root...

76 FR 54758 - Alliance Pipeline L.P.; Notice of Intent To Prepare an Environmental Assessment for the Planned...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-02

... Counties, North Dakota; A 4,500 horsepower compressor station containing two natural gas-driven engines... included in the User's Guide under the ``e-filing'' link on the Commission's Web site. Please note that the... on ``General Search'' and enter the docket number, excluding the last three digits in the Docket...

Modeling and optimization of the air system in polymer exchange membrane fuel cell systems

NASA Astrophysics Data System (ADS)

Bao, Cheng; Ouyang, Minggao; Yi, Baolian

Stack and air system are the two most important components in the fuel cell system (FCS). It is meaningful to study their properties and the trade-off between them. In this paper, a modified one-dimensional steady-state analytical fuel cell model is used. The logarithmic mean of the inlet and the outlet oxygen partial pressure is adopted to avoid underestimating the effect of air stoichiometry. And the pressure drop model in the grid-distributed flow field is included in the stack analysis. Combined with the coordinate change preprocessing and analog technique, neural network is used to treat the MAP of compressor and turbine in the air system. Three kinds of air system topologies, the pure screw compressor, serial booster and exhaust expander are analyzed in this article. A real-code genetic algorithm is programmed to obtain the global optimum air stoichiometric ratio and the cathode outlet pressure. It is shown that the serial booster and expander with the help of exhaust recycling, can improve more than 3% in the FCS efficiency comparing to the pure screw compressor. As the net power increases, the optimum cathode outlet pressure keeps rising and the air stoichiometry takes on the concave trajectory. The working zone of the proportional valve is also discussed. This presented work is helpful to the design of the air system in fuel cell system. The steady-state optimum can also be used in the dynamic control.

An analysis of booster tone noise using a time-linearized Navier-Stokes solver

NASA Astrophysics Data System (ADS)

Wukie, Nathan A.

This thesis details a computational investigation of tone noise generated from a booster(low-pressure compressor) in a fan test rig. The computational study consisted of sets of time-linearized Navier-Stokes simulations in the booster region to investigate the blade-wake interactions that act as the primary noise-generating mechanism for the booster blade-passing frequency and harmonics. An acoustic test database existed with data at several operating points for the fan test rig that was used to compare against the predicted noise data from the computational study. It is shown that the computational methodology is able to capture trends in sound power for the 1st and 2nd booster tones along the operating line for the rig. It is also shown that the computational study underpredicts one of the tones at low power and is not able to capture a peak in the data at the Cutback condition. Further investigation of this type is warranted to quantify the source of discrepancies between the computational and experimental data as the reflected transmisison of sound off the fan through the bypass duct was not accounted for in this study.

75 FR 46868 - Airworthiness Directives; The Boeing Company Model 747 Airplanes and Model 767 Airplanes Equipped...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-04

... crystal accretion. However, at this time, we do not agree to pursue research to develop an ice detector... significantly different type-design booster from that of the GE Model CF6-80C2 series engines (GE Model CF6-80A... events recorded on GE Model CF6-80A series engines. While this engine has a similar compressor design...

Preliminary study of Low-Cost Micro Gas Turbine

NASA Astrophysics Data System (ADS)

Fikri, M.; Ridzuan, M.; Salleh, Hamidon

2016-11-01

The electricity consumption nowadays has increased due to the increasing development of portable electronic devices. The development of low cost micro gas turbine engine, which is designed for the purposes of new electrical generation Micro turbines are a relatively new distributed generation technology being used for stationary energy generation applications. They are a type of combustion turbine that produces both heat and electricity on a relatively small scaled.. This research are focusing of developing a low-cost micro gas turbine engine based on automotive turbocharger and to evaluation the performance of the developed micro gas turbine. The test rig engine basically was constructed using a Nissan 45V3 automotive turbocharger, containing compressor and turbine assemblies on a common shaft. The operating performance of developed micro gas turbine was analyzed experimentally with the increment of 5000 RPM on the compressor speed. The speed of the compressor was limited at 70000 RPM and only 1000 degree Celsius at maximum were allowed to operate the system in order to avoid any failure on the turbocharger bearing and the other components. Performance parameters such as inlet temperature, compressor temperature, exhaust gas temperature, and fuel and air flow rates were measured. The data was collected electronically by 74972A data acquisition and evaluated manually by calculation. From the independent test shows the result of the system, The speed of the LP turbine can be reached up to 35000 RPM and produced 18.5kw of mechanical power.

Corner flow control in high through-flow axial commercial fan/booster using blade 3-D optimization

NASA Astrophysics Data System (ADS)

Zhu, Fang; Jin, Donghai; Gui, Xingmin

2012-02-01

This study is aimed at using blade 3-D optimization to control corner flows in the high through-flow fan/booster of a high bypass ratio commercial turbofan engine. Two kinds of blade 3-D optimization, end-bending and bow, are focused on. On account of the respective operation mode and environment, the approach to 3-D aerodynamic modeling of rotor blades is different from stator vanes. Based on the understanding of the mechanism of the corner flow and the consideration of intensity problem for rotors, this paper uses a variety of blade 3-D optimization approaches, such as loading distribution optimization, perturbation of departure angles and stacking-axis manipulation, which are suitable for rotors and stators respectively. The obtained 3-D blades and vanes can improve the corner flow features by end-bending and bow effects. The results of this study show that flows in corners of the fan/booster, such as the fan hub region, the tip and hub of the vanes of the booster, are very complex and dominated by 3-D effects. The secondary flows there are found to have a strong detrimental effect on the compressor performance. The effects of both end-bending and bow can improve the flow separation in corners, but the specific ways they work and application scope are somewhat different. Redesigning the blades via blade 3-D optimization to control the corner flow has effectively reduced the loss generation and improved the stall margin by a large amount.

Westinghouse to launch coal gasifier with combined cycle unit

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stavsky, R.M.; Margaritis, P.J.

1980-03-01

Following an extensive test program with a prototype coal gasifier, Westinghouse Electric Corp. is now offering an integrated gasifier/combined-cycle unit as a feasible alternative for generating power from coal in an efficient, clean manner. The Westinghouse gasification process uses a single-stage pressurized fluidized-bed reactor, followed by heat recovery, gas cleaning, sulfur and amonia removal and recovery, and gas reheat. The system produces a fuel gas free of sulfur and other contaminants from crushed run-of-mine coals of varying reactivities and caking properties. The by-products include ammonia and sulfur and an agglomerated ash residue that serves as an acceptable landfill. Air formore » the gasifier is bled from the gas-turbine air compressor and further pressurized with a booster compressor. The hot exhaust gases from the gas turbine pass through a heat-recovery steam generator that produces sufficient steam to drive a turbine providing about 40% of the total electricity generated in the plant.« less

Process control of turboexpander plants

DOE Office of Scientific and Technical Information (OSTI.GOV)

Guffey, C.G.; Heenan, W.A.

1984-05-01

The turboexpander process uses the high pressure of the natural gas stream to drive a rotating expander wheel to extract mechanical work from the flowing stream. The removal of energy and the reduced pressure result in a large refrigeration effect which condenses ethane, propane and heavier components in the natural gas as liquids for recovery and sale. The recovered work is transmitted directly to a shaft which usually drives a gas recompressor. This compressor increases the pressure of the dry residue gas after liquid recovery. Operation of the demethanizer or de-ethanizer at the low pressure of the main gas streammore » eliminates the requirement for a separate demethanizer overhead gas booster compressor. There are many variations of this simplified process including supplemental inlet refrigeration, parallel trains of heat exchangers, side reboilers on the demethanizer and multiple expanders which must be controlled and affect the dynamic response to variable changes. This paper excludes these complications in the analysis of the system.« less

Full 3D Analysis of the GE90 Turbofan Primary Flowpath

NASA Technical Reports Server (NTRS)

Turner, Mark G.

2000-01-01

The multistage simulations of the GE90 turbofan primary flowpath components have been performed. The multistage CFD code, APNASA, has been used to analyze the fan, fan OGV and booster, the 10-stage high-pressure compressor and the entire turbine system of the GE90 turbofan engine. The code has two levels of parallel, and for the 18 blade row full turbine simulation has 87.3 percent parallel efficiency with 121 processors on an SGI ORIGIN. Grid generation is accomplished with the multistage Average Passage Grid Generator, APG. Results for each component are shown which compare favorably with test data.

Generation of 1-J bursts with picosecond pulses from Perla B thin-disk laser system

NASA Astrophysics Data System (ADS)

Chyla, Michal; Nagisetty, Siva S.; Severova, Patricie; Zhou, Huang; Smrz, Martin; Endo, Akira; Mocek, Tomas

2018-02-01

In many fields of modern physics and industrial applications high-average power pulsed diode-pumped solid-state lasers are essential. Scaling of these lasers towards higher pulse energies is often limited by the onset of thermal effects which are determined by the average power. In this paper we would like to propose a way of increasing the pulse energies by operating the PERLA B laser system in 100 Hz burst mode with 1 ms burst duration and intra-burst repetition rate of 10 kHz. The CPA-based system incorporates fiber front-end, regenerative amplifier and the multipass amplifier followed by the booster amplifier and <2ps compressor.

Coupled-Flow Simulation of HP-LP Turbines Has Resulted in Significant Fuel Savings

NASA Technical Reports Server (NTRS)

Veres, Joseph P.

2001-01-01

Our objective was to create a high-fidelity Navier-Stokes computer simulation of the flow through the turbines of a modern high-bypass-ratio turbofan engine. The simulation would have to capture the aerodynamic interactions between closely coupled high- and low-pressure turbines. A computer simulation of the flow in the GE90 turbofan engine's high-pressure (HP) and low-pressure (LP) turbines was created at GE Aircraft Engines under contract with the NASA Glenn Research Center. The three-dimensional steady-state computer simulation was performed using Glenn's average-passage approach named APNASA. The areas upstream and downstream of each blade row mutually interact with each other during engine operation. The embedded blade row operating conditions are modeled since the average passage equations in APNASA actively include the effects of the adjacent blade rows. The turbine airfoils, platforms, and casing are actively cooled by compressor bleed air. Hot gas leaks around the tips of rotors through labyrinth seals. The flow exiting the high work HP turbines is partially transonic and, therefore, has a strong shock system in the transition region. The simulation was done using 121 processors of a Silicon Graphics Origin 2000 (NAS 02K) cluster at the NASA Ames Research Center, with a parallel efficiency of 87 percent in 15 hr. The typical average-passage analysis mesh size per blade row was 280 by 45 by 55, or approx.700,000 grid points. The total number of blade rows was 18 for a combined HP and LP turbine system including the struts in the transition duct and exit guide vane, which contain 12.6 million grid points. Design cycle turnaround time requirements ran typically from 24 to 48 hr of wall clock time. The number of iterations for convergence was 10,000 at 8.03x10(exp -5) sec/iteration/grid point (NAS O2K). Parallel processing by up to 40 processors is required to meet the design cycle time constraints. This is the first-ever flow simulation of an HP and LP turbine. In addition, it includes the struts in the transition duct and exit guide vanes.

Shape Changing Airfoil

NASA Technical Reports Server (NTRS)

Ott, Eric A.

2005-01-01

Scoping of shape changing airfoil concepts including both aerodynamic analysis and materials-related technology assessment effort was performed. Three general categories of potential components were considered-fan blades, booster and compressor blades, and stator airfoils. Based on perceived contributions to improving engine efficiency, the fan blade was chosen as the primary application for a more detailed assessment. A high-level aerodynamic assessment using a GE90-90B Block 4 engine cycle and fan blade geometry indicates that blade camber changes of approximately +/-4deg would be sufficient to result in fan efficiency improvements nearing 1 percent. Constraints related to flight safety and failed mode operation suggest that use of the baseline blade shape with actuation to the optimum cruise condition during a portion of the cycle would be likely required. Application of these conditions to the QAT fan blade and engine cycle was estimated to result in an overall fan efficiency gain of 0.4 percent.

CO2 Supermarket Refrigeration Systems for Southeast Asia and the USA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sharma, Vishaldeep; Fricke, Brian A; Bansal, Pradeep

This paper presents a comparative analysis of the annual energy consumption of these refrigeration systems in eighty eight cities from all climate zones in Southeast Asia. Also, the performance of the CO2 refrigeration systems is compared to the baseline R404A multiplex direct expansion (DX) system. Finally, the overall performance of the CO2 refrigeration systems in various climatic conditions in Southeast Asia is compared to that in the United States. For the refrigeration systems investigated, it was found that the Transcritical Booster System with Bypass Compressor (TBS-BC) performs better or equivalent to the R404A multiplex DX system in the northern regionsmore » of Southeast Asia (China and Japan). In the southern regions of Southeast Asia (India, Bangladesh, Burma), the R404A multiplex DX system and the Combined Secondary Cascade (CSC) system performs better than the TBS-BC.« less

Viscous Three-Dimensional Simulation of Flow in an Axial Low Pressure Compressor at Engine Icing Operating Points

NASA Technical Reports Server (NTRS)

Rigby, David L.; Ameri, Ali A.; Veres, Joe; Jorgenson, Philip C. E.

2017-01-01

Viscous three-dimensional simulations of the Honeywell ALF502R-5 low pressure compressor (sometimes called a booster) using the NASA Glenn code GlennHT have been carried out. A total of ten simulations were produced. Five operating points are investigated, with each point run with two different wall thermal conditions. These operating points are at, or near, points where engine icing has been determined to be likely. In the future, the results of this study will be used for further analysis such as predicting collection efficiency of ice particles and ice growth rates at various locations in the compressor. A mixing plane boundary condition is used between each blade row, resulting in convergence to steady state within each blade row. The k-omega turbulence model of Wilcox, combined with viscous grid spacing near the wall on the order of one, is used to resolve the turbulent boundary layers. For each of the operating points, heat transfer coefficients are generated on the blades and walls. The heat transfer coefficients are produced by running the operating point with two different wall thermal conditions and then solving simultaneously for the heat transfer coefficient and adiabatic wall temperature at each point. Average Nusselt numbers are calculated for the most relevant surfaces. The values are seen to scale with Reynolds number to approximately a power of 0.7. Additionally, images of surface distribution of Nusselt number are presented. Qualitative comparison between the five operating points show that there is relatively little change in the character of the distribution. The dominant observed effect is that of an overall scaling, which is expected due to Reynolds number differences. One interesting aspect about the Nusselt number distribution is observed on the casing (outer diameter) downstream of the exit guide vanes (EGVs). The Nusselt number is relatively high between the pairs of EGVs, with two lower troughs downstream of each EGV trailing edge. This is of particular interest since rather complex ice shapes have been observed in that region.

Design of a 2 kA, 30 fs Rf-Photoinjector for Waterbag Compression

NASA Astrophysics Data System (ADS)

van der Geer, S. B.; Luiten, O. J.; de Loos, M. J.

Because uniformly filled ellipsoidal ‘waterbag’ bunches have linear self-fields in all dimensions, they do not suffer from space-charge induced brightness degradation. This in turn allows very efficient longitudinal compression of high-brightness bunches at sub or mildly relativistic energies, a parameter regime inaccessible up to now due to detrimental effects of non-linear space-charge forces. To demonstrate the feasibility of this approach, we investigate ballistic bunching of 1 MeV, 100 pC waterbag electron bunches, created in a half-cell rf-photogun, by means of a two-cell booster-compressor. Detailed GPT simulations of this table-top set-up are presented, including realistic fields, 3D space-charge effects, path-length differences and image charges at the cathode. It is shown that with a single 10MW S-band klystron and fields of 100 MV/m, 2kA peak current is attainable with a pulse duration of only 30 fs at a transverse normalized emittance of 1.5 μm.

Boosting devices with integral features for recirculating exhaust gas

DOEpatents

Wu, Ko -Jen

2015-09-15

According to one embodiment of the invention, a compressor housing includes a compressor inlet in fluid communication with a compressor volute configured to house a compressor wheel, the compressor inlet configured to provide a first air flow to the compressor wheel and a compressor outlet in fluid communication with the compressor volute, the compressor outlet configured to direct a compressed gas to an intake manifold. The compressor housing further includes an exhaust gas recirculation inlet port in fluid communication with the compressor volute, the exhaust gas recirculation inlet port being configured to combine an exhaust gas flow with the air flow to the compressor wheel.

76 FR 9771 - SFPP, L.P.; SFPP, L.P.; SFPP, L.P.; SFPP, L.P.; Notice of Filing

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-22

..., L.P.; SFPP, L.P.; SFPP, L.P.; SFPP, L.P.; Notice of Filing Take notice that on February 10, 2011, the SFPP, L.P. filed with the Commission a proposal to provide refunds to shippers who were not... orders dated December 8, 2006 (SFPP, L.P., 117 FERC ] 61, 285 (2007)), December 26, 2007 (SFPP, L.P., 121...

Analysis of Liquid Propellant Exposed to Elastomeric Materials

DTIC Science & Technology

1989-12-01

Rubber LP-l NBR -2 B. Nitrile Rubber LP-2 N-BR-8 LP-3 NBR -9 LP-4 1203-F60-R2, RADIAN LP-5 VT-380 ( NBR /PVC), RADIAN LP-6 BJLT MI-40, UNIROYAL LP-7 OZO-HA...0221 (70% NBR /30% PVC), UNIROYAL C. Carboxylated Nitrile Rubber LP-8 XNBR-2 LP-9 XN BR-3 LP-10 XNBR-6 D. Polychioroprene Rubber LP-11 CR-i LP-12 CR-2...compatibility of liquid propellants is also determined by the degradation of the propellant by decomposition, by the solution of ballistically undesirable

High ratio recirculating gas compressor

DOEpatents

Weinbrecht, J.F.

1989-08-22

A high ratio positive displacement recirculating rotary compressor is disclosed. The compressor includes an integral heat exchanger and recirculation conduits for returning cooled, high pressure discharge gas to the compressor housing to reducing heating of the compressor and enable higher pressure ratios to be sustained. The compressor features a recirculation system which results in continuous and uninterrupted flow of recirculation gas to the compressor with no direct leakage to either the discharge port or the intake port of the compressor, resulting in a capability of higher sustained pressure ratios without overheating of the compressor. 10 figs.

Texture Classification with Change Point Statistics.

DTIC Science & Technology

1981-07-01

it is necessary to let T approach the value of n for an nxn image. This is motivated by the fact that the computation of Ut, T is so costly, and if T...LP4 - - + ML4 + + + pS4 + - + LP5 + - + ML5 + + + PS5 + + + LP6 + - + ML6 + + + PS6 + - + LP7 - + - ML7 - + - PS7 + - + LP8 - + - ML8 - - - PS8...LP2 + + + ML2 - - - PS2 + - - LP3 - + - ML3 - - - PS3 + + + LP4 - + + ML4 + + + PS4 - - - LP5 - - + ML5 - + - PS5 - + + LP6 - + + KL6 - - - PS6

PLC-based mode multi/demultiplexers for mode division multiplexing

NASA Astrophysics Data System (ADS)

Saitoh, Kunimasa; Hanzawa, Nobutomo; Sakamoto, Taiji; Fujisawa, Takeshi; Yamashita, Yoko; Matsui, Takashi; Tsujikawa, Kyozo; Nakajima, Kazuhide

2017-02-01

Recently developed PLC-based mode multi/demultiplexers (MUX/DEMUXs) for mode division multiplexing (MDM) transmission are reviewed. We firstly show the operation principle and basic characteristics of PLC-based MUX/DEMUXs with an asymmetric directional coupler (ADC). We then demonstrate the 3-mode (2LP-mode) multiplexing of the LP01, LP11a, and LP11b modes by using fabricated PLC-based mode MUX/DEMUX on one chip. In order to excite LP11b mode in the same plane, a PLC-based LP11 mode rotator is introduced. Finally, we show the PLC-based 6-mode (4LP-mode) MUX/DEMUX with a uniform height by using ADCs, LP11 mode rotators, and tapered waveguides. It is shown that the LP21a mode can be excited from the LP11b mode by using ADC, and the two nearly degenerated LP21b and LP02 modes can be (de)multiplexed separately by using tapered mode converter from E13 (E31) mode to LP21b (LP02) mode.

Exploratory Phase for Optimizing Lifetime Position 4 of the COS/FUV Detector

NASA Astrophysics Data System (ADS)

Roman-Duval, Julia; Indriolo, Nick; De Rosa, Gisella; Fox, Andrew; Oliveira, Cristina; Penton, Steve; Sahnow, David; Sonnentrucker, Paule; White, James

2018-05-01

The COS/FUV detector uses a microchannel plate, whose response (gain) decreases with usage, a process called gain-sag. To mitigate these gain-sag effects, COS/FUV science spectra are periodically moved to pristine locations of the detector, i.e. different lifetime positions (LP). Preparations for the move from LP3 to LP4 started with an exploratory phase between May and October 2016, while the LP4 move occurred on October 2, 2017. This ISR describes the LP4 exploratory phase, during which the feasibility of placing LP4 at -2.5'' below LP3 (-5'' below LP1) was examined, the effects of the LP4 move on the science quality and calibration accuracy of spectra were investigated, and the final location of LP4 (- 2.5'' below LP3) was determined. We describe in detail the strategy adopted for the LP4 exploratory phase to ensure that all potential issues were identified and resolved well in advance of the LP4 move.

Helium compressors for closed-cycle, 4.5-Kelvin refrigerators

NASA Technical Reports Server (NTRS)

Hanson, T. R.

1992-01-01

An improved helium compressor for traveling-wave maser and closed-cycle refrigerator systems was developed and is currently being supplied to the DSN. This new 5-hp compressor package is designed to replace the current 3-hp DSN compressors. The new compressor package was designed to retrofit into the existing 3-hp compressor frame and reuse many of the same components, therefore saving the cost of documenting and fabricating these components when implementing a new 5-hp compressor.

Lipoprotein(a): more interesting than ever after 50 years.

PubMed

Dubé, Joseph B; Boffa, Michael B; Hegele, Robert A; Koschinsky, Marlys L

2012-04-01

Lipoprotein(a) [Lp(a)] is a risk factor for cardiovascular disease; we highlight the most recent research initiatives that have sought to define Lp(a)-dependent pathogenicity as well as pharmacologic approaches to lowering Lp(a). Recent large-scale meta-analyses have confirmed elevated Lp(a) concentrations to be a moderate but consistent prospective coronary heart disease (CHD) risk factor. The Mendelian randomization approach has also associated LPA variants with Lp(a) concentration and CHD risk. Discoveries linking Lp(a) to oxidized phospholipid burden have implicated a proinflammatory role for Lp(a) hinting at a new mechanism underlying the association with CHD risk, which adds to previous atherogenic and thrombogenic mechanisms. Most existing Lp(a)-lowering drug treatments almost always show simultaneous effects on other lipoproteins, making it difficult to assign any clinical outcome specifically to the effects of Lp(a) lowering. Early experiments with antisense oligonucleotides targeting apolipoprotein(a) mRNA seem to indicate the pleiotropic effects of Lp(a) reduction on LDL and HDL in mice. The mechanism linking Lp(a) concentration with concentrations of other blood lipids remains unknown but may provide an insight into Lp(a) metabolism. Despite the wealth of epidemiologic evidence supporting Lp(a) concentration as a CHD risk factor, the lack of a definitive functional mechanism involving an Lp(a)-dependent pathway in CHD pathogenesis has limited the potential clinical connotation of Lp(a). However, the application of novel technologies to the long-standing mysteries of Lp(a) biology seems to provide the opportunity for expanding our understanding of Lp(a) and its complex role in cardiovascular health.

Detection of varicella-zoster virus antigens in lesional skin of zosteriform lichen planus but not in that of linear lichen planus.

PubMed

Mizukawa, Y; Horie, C; Yamazaki, Y; Shiohara, T

2012-01-01

Distinctions between 'linear lichen planus' (LP) and 'zosteriform LP' are difficult to determine solely based on clinical findings. The aim of this study is to determine whether the presence of the varicella-zoster virus (VZV) antigens could be used to differentiate the zosteriform LP from the linear LP. We immunohistochemically investigated the presence of in vivo localization of VZV antigens in 8 LP lesions (zosteriform LP: n = 5, linear LP: n = 3). We describe 2 cases of zosteriform LP without apparent prior episodes of herpes zoster, in whom VZV antigens were detected in the eccrine epithelium. Further analysis showed that VZV antigens were exclusively detected in the eccrine epithelium in the zosteriform LP lesions, but not in the linear LP lesions. Etiological differences exist between zosteriform LP and linear LP. The presence of VZV antigens in lesional skin of the former indicates a possible triggering role of this virus in the pathogenesis of this variant. Copyright © 2012 S. Karger AG, Basel.

Study Improving Performance of Centrifugal Compressor In Paiton Coal Fired Power Plant Unit 1 And 2

NASA Astrophysics Data System (ADS)

Kusuma, Yuriadi; Permana, Dadang S.

2018-03-01

The compressed air system becomes part of a very important utility system in a Plant, including the Steam Power Plant. In PLN’S coal fired power plant, Paiton units 1 and 2, there are four Centrifugal air compressor types, which produce compressed air as much as 5.652 cfm and with electric power capacity of 1200 kW. Electricity consumption to operate centrifugal compressor is 7.104.117 kWh per year. This study aims to measure the performance of Centrifugal Compressors operating in Paiton’s coal fired power plant units 1 and 2. Performance Compressor is expressed by Specific Power Consumption (SPC) in kW/100 cfm. For this purpose, we measure the compressed air flow rate generated by each compressor and the power consumed by each compressor. The result is as follows Air Compressor SAC 2B : 15.1 kW/100 cfm, Air Compressor SAC 1B : 15.31 kW/100 cfm,Air Compressor SAC 1A : 16.3 kW/100 cfm and air Compressor SAC 2C : 18.19 kW/100 cfm. From the measurement result, air compressor SAC 2B has the best performance that is 15.1 kW / 100 cfm. In this study we analyze efforts to improve the performance of other compressors to at least match the performance of the SAC 2B air compressor. By increasing the Specific Power Consumption from others Compressor, it will get energy saving up to 284,165 kWh per year.

Transverse stress induced LP 02-LP 21 modal interference of stimulated Raman scattered light in a few-mode optical fiber

NASA Astrophysics Data System (ADS)

Sharma, A.; Posey, R.

1996-02-01

Four-photon mixing followed by stimulated Raman scattering is observed in LP 02 mode in a 7.9 μm core diameter optical fiber. A localized transverse stress efficiency couples LP 02 to the LP 21 mode with a macroscopic beat length of 1.8 mm. LP 02-LP 21 modal interference is investigated by detecting the 550-590 nm SRS through a pinhole in the far field exit plane. Quantitative explanation of wavelength dependent intensity modulation results in a precise experimental determination of {∂[β 02(λ) - β 21(λ)] }/{∂λ}, for mode-propagation constants β02( λ) and β21( λ) of LP 02 and LP 21 modes respectively, as well as Δ, the relative core-cladding refractive index difference. The LP 02-LP 21 modal interference is used for sensing of temperature between 50-300°C.

Turbo-alternator-compressor design for supercritical high density working fluids

DOEpatents

Wright, Steven A.; Fuller, Robert L.

2013-03-19

Techniques for generating power are provided. Such techniques involve a thermodynamic system including a housing, a turbine positioned in a turbine cavity of the housing, a compressor positioned in a compressor cavity of the housing, and an alternator positioned in a rotor cavity between the turbine and compressor cavities. The compressor has a high-pressure face facing an inlet of the compressor cavity and a low-pressure face on an opposite side thereof. The alternator has a rotor shaft operatively connected to the turbine and compressor, and is supported in the housing by bearings. Ridges extending from the low-pressure face of the compressor may be provided for balancing thrust across the compressor. Seals may be positioned about the alternator for selectively leaking fluid into the rotor cavity to reduce the temperature therein.

Comparative analysis of various CO 2 configurations in supermarket refrigeration systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sharma, Vishaldeep; Fricke, Brian; Bansal, Pradeep

Our paper presents an analysis of various CO 2 transcritical and cascade/secondary loop refrigeration systems that are becoming popular in supermarket applications with the objective of optimizing the operating parameters of these systems. In addition, the performance of selected CO 2-based refrigeration systems is compared to the baseline R404A multiplex direct expansion system using bin analyses in the eight climate zones of the United States. Moreover, for the refrigeration systems investigated, it was found that the Transcritical Booster System with Bypass Compressor (TBS-BC) had the lowest energy consumption for ambient temperatures (T amb) less than 8 °C, and for highermore » ambient temperatures the R404A direct expansion system was found to have the lowest energy consumption. Finally, the TBS-BC performs equivalent to or better than the R404A direct expansion system in the northern two-thirds of the US. For the southern portion of the US, the R404A multiplex DX system performs better than CO 2 systems.« less

Comparative analysis of various CO 2 configurations in supermarket refrigeration systems

DOE PAGES

Sharma, Vishaldeep; Fricke, Brian; Bansal, Pradeep

2014-07-09

Our paper presents an analysis of various CO 2 transcritical and cascade/secondary loop refrigeration systems that are becoming popular in supermarket applications with the objective of optimizing the operating parameters of these systems. In addition, the performance of selected CO 2-based refrigeration systems is compared to the baseline R404A multiplex direct expansion system using bin analyses in the eight climate zones of the United States. Moreover, for the refrigeration systems investigated, it was found that the Transcritical Booster System with Bypass Compressor (TBS-BC) had the lowest energy consumption for ambient temperatures (T amb) less than 8 °C, and for highermore » ambient temperatures the R404A direct expansion system was found to have the lowest energy consumption. Finally, the TBS-BC performs equivalent to or better than the R404A direct expansion system in the northern two-thirds of the US. For the southern portion of the US, the R404A multiplex DX system performs better than CO 2 systems.« less

Aerodynamic Design of Axial Flow Compressors

NASA Technical Reports Server (NTRS)

Bullock, R. O. (Editor); Johnsen, I. A.

1965-01-01

An overview of 'Aerodynamic systems design of axial flow compressors' is presented. Numerous chapters cover topics such as compressor design, ptotential and viscous flow in two dimensional cascades, compressor stall and blade vibration, and compressor flow theory. Theoretical aspects of flow are also covered.

Elevated serum β₂-GPI-Lp(a) complexes levels in children with nephrotic syndrome.

PubMed

Zhang, Chunni; Luo, Yang; Huang, Zhongwei; Xia, Zhengkun; Cai, Xiaoyi; Yang, Yuhua; Niu, Dongmei; Wang, Junjun

2012-10-09

The complexes of β₂-glycoprotein I (β₂-GPI) with lipoprotein(a) [β₂-GPI-Lp(a)] exist in human circulation and are increased in serum from patients with some autoimmune diseases. This study aims to investigate the concentration of β₂-GPI-Lp(a) in serum of children with idiopathic nephrotic syndrome (NS) and its relationship with serum lipids, oxidized lipoprotein and renal function parameters to explore the potential of the complexes as an additional marker for evaluating pediatric NS. Serum concentrations of β₂-GPI-Lp(a) complexes and oxidized Lp(a) [ox-Lp(a)] were measured by "Sandwich" ELISAs in 80 NS children and 82 age/sex-matched healthy controls. The levels of serum lipids and kidney parameters were also determined. Multivariate logistic regression analysis was performed to identify correlate of β₂-GPI-Lp(a) and NS. The serum concentrations of β₂-GPI-Lp(a) complexes in children with NS were significantly higher than those in controls (median 0.95 U/ml vs 0.28 U/ml, P<0.0001). Ox-Lp(a) levels were also markedly elevated (median 14.55 mg/l vs 2.60 mg/l, P<0.0001] in NS children. The concentrations of β₂-GPI-Lp(a) were positively correlated with ox-Lp(a) (r=0.246, P=0.028), but not with Lp(a) level, and the concentrations of ox-Lp(a) were positively related with Lp(a) (r=0.301, P=0.007) in NS children. Multivariate logistic regression analysis identified a positive association between NS and β₂-GPI-Lp(a) (OR=13.694, 95% CI 6.400-29.299, P<0.0001), after adjusting for kidney function parameters, serum lipids and ox-Lp(a). Elevated β₂-GPI-Lp(a) level was an independent and significant risk factor for pediatric NS and, enhanced Lp(a) oxidation partly contributes to the formation of β₂-GPI-Lp(a) complexes. Copyright © 2012 Elsevier B.V. All rights reserved.

Reference values for Lactate Pro 2™ in fetal blood sampling during labor: a cross-sectional study.

PubMed

Birgisdottir, Brynhildur Tinna; Holzmann, Malin; Varli, Ingela Hulthén; Graner, Sofie; Saltvedt, Sissel; Nordström, Lennart

2017-04-01

Lactate Pro™ (LP1) is the only lactate meter evaluated for fetal scalp blood sampling (FBS) in intrapartum use. The reference values for this meter are: normal value <4.2 mmol/L, preacidemia 4.2-4.8 mmol/L, and acidemia >4.8 mmol/L. The production of this meter has been discontinued. An updated version, Lactate Pro 2TM (LP2), has been launched and is shown to be differently calibrated. The aims of the study were to retrieve a conversion equation to convert lactate values in FBS measured with LP2 to an estimated value if using LP1 and to define reference values for clinical management when using LP2. A cross-sectional study was conducted at a university hospital in Sweden. A total of 113 laboring women with fetal heart rate abnormalities on cardiotocography (CTG) had FBS carried out. Lactate concentration was measured bedside with both LP1 and LP2 from the same blood sample capillary. A linear regression model was constructed to retrieve a conversion equation to convert LP2 values to LP1 values. LP2 measured higher values than LP1 in all analyses. We found that 4.2 mmol/L with LP1 corresponded to 6.4 mmol/L with LP2. Likewise, 4.8 mmol/L with LP1 corresponded to 7.3 mmol/L with LP2. The correlation between the analyses was excellent (Spearman's rank correlation, r=0.97). We recommend the following guidelines when interpreting lactate concentration in FBS with LP2: <6.4 mmol/L to be interpreted as normal, 6.4-7.3 mmol/L as preacidemia indicating a follow-up FBS within 20-30 min, and >7.3 mmol/L as acidemia indicating intervention.

30 CFR 57.13010 - Reciprocating-type air compressors.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Reciprocating-type air compressors. 57.13010... Air and Boilers § 57.13010 Reciprocating-type air compressors. (a) Reciprocating-type air compressors... than 25 percent. (b) However, this standard does not apply to reciprocating-type air compressors rated...

30 CFR 57.13010 - Reciprocating-type air compressors.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Reciprocating-type air compressors. 57.13010... Air and Boilers § 57.13010 Reciprocating-type air compressors. (a) Reciprocating-type air compressors... than 25 percent. (b) However, this standard does not apply to reciprocating-type air compressors rated...

49 CFR 192.736 - Compressor stations: Gas detection.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 3 2012-10-01 2012-10-01 false Compressor stations: Gas detection. 192.736... Compressor stations: Gas detection. (a) Not later than September 16, 1996, each compressor building in a compressor station must have a fixed gas detection and alarm system, unless the building is— (1) Constructed...

49 CFR 192.736 - Compressor stations: Gas detection.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 3 2014-10-01 2014-10-01 false Compressor stations: Gas detection. 192.736... Compressor stations: Gas detection. (a) Not later than September 16, 1996, each compressor building in a compressor station must have a fixed gas detection and alarm system, unless the building is— (1) Constructed...

49 CFR 192.736 - Compressor stations: Gas detection.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 3 2011-10-01 2011-10-01 false Compressor stations: Gas detection. 192.736... Compressor stations: Gas detection. (a) Not later than September 16, 1996, each compressor building in a compressor station must have a fixed gas detection and alarm system, unless the building is— (1) Constructed...

49 CFR 192.736 - Compressor stations: Gas detection.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 3 2013-10-01 2013-10-01 false Compressor stations: Gas detection. 192.736... Compressor stations: Gas detection. (a) Not later than September 16, 1996, each compressor building in a compressor station must have a fixed gas detection and alarm system, unless the building is— (1) Constructed...

33 CFR 154.826 - Vapor compressors and blowers.

Code of Federal Regulations, 2010 CFR

2010-07-01

...) Excessive shaft bearing temperature. (d) If a centrifugal compressor, fan, or lobe blower handles vapor in... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Vapor compressors and blowers....826 Vapor compressors and blowers. (a) Each inlet and outlet to a compressor or blower which handles...

Compressor bleed cooling fluid feed system

DOEpatents

Donahoo, Eric E; Ross, Christopher W

2014-11-25

A compressor bleed cooling fluid feed system for a turbine engine for directing cooling fluids from a compressor to a turbine airfoil cooling system to supply cooling fluids to one or more airfoils of a rotor assembly is disclosed. The compressor bleed cooling fluid feed system may enable cooling fluids to be exhausted from a compressor exhaust plenum through a downstream compressor bleed collection chamber and into the turbine airfoil cooling system. As such, the suction created in the compressor exhaust plenum mitigates boundary layer growth along the inner surface while providing flow of cooling fluids to the turbine airfoils.

Increase of Gas-Turbine Plant Efficiency by Optimizing Operation of Compressors

NASA Astrophysics Data System (ADS)

Matveev, V.; Goriachkin, E.; Volkov, A.

2018-01-01

The article presents optimization method for improving of the working process of axial compressors of gas turbine engines. Developed method allows to perform search for the best geometry of compressor blades automatically by using optimization software IOSO and CFD software NUMECA Fine/Turbo. The calculation of the compressor parameters was performed for work and stall point of its performance map on each optimization step. Study was carried out for seven-stage high-pressure compressor and three-stage low-pressure compressors. As a result of optimization, improvement of efficiency was achieved for all investigated compressors.

23. Station Compressor Room 1 with Air Compressors and Accumulator ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

23. Station Compressor Room 1 with Air Compressors and Accumulator Tanks, view to the south. One of the two large station air compressor units used for depressing the draft tube water level is visible atop a concrete pedestal on the left side of photograph (the second identical compressor is located in an adjacent room). Two of the six station air accumulator tanks are visible in the background. The smaller station service air compressor is visible in right foreground of the photograph was installed in the early 1980s, and replaced the original station service air compressor. - Washington Water Power Clark Fork River Noxon Rapids Hydroelectric Development, Powerhouse, South bank of Clark Fork River at Noxon Rapids, Noxon, Sanders County, MT

Control means for a gas turbine engine

NASA Technical Reports Server (NTRS)

Beitler, R. S.; Sellers, F. J.; Bennett, G. W. (Inventor)

1982-01-01

A means is provided for developing a signal representative of the actual compressor casing temperature, a second signal representative of compressor inlet gas temperature, and a third signal representative of compressor speed. Another means is provided for receiving the gas temperature and compressor speed signals and developing a schedule output signal which is a representative of a reference casing temperature at which a predetermined compressor blade stabilized clearance is provided. A means is also provided for comparing the actual compressor casing temperature signal and the reference casing temperature signal and developing a clearance control system representative of the difference. The clearance control signal is coupled to a control valve which controls a flow of air to the compressor casing to control the clearance between the compressor blades and the compressor casing. The clearance control signal can be modified to accommodate transient characteristics. Other embodiments are disclosed.

Stage effects on stalling and recovery of a high-speed 10-stage axial-flow compressor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Copenhaver, W.W.

1988-01-01

Results of a high-speed 10-stage axial-flow compressor test involving overall compressor and individual stage performance while stalling and operating in quasi-steady rotating stall are described. Test procedures and data-acquisition methods used to obtain the dynamic stalling and quasi-steady in-stall data are explained. Unstalled and in-stall time-averaged data obtained from the compressor operating at five different shaft speeds and one off-schedule variable vane condition are presented. Effects of compressor speed and variable geometry on overall compressor in-stall pressure rise and hysteresis extent are illustrated through the use of quasi-steady-stage temperature rise and pressure-rise characteristics. Results indicate that individual stage performance duringmore » overall compressor rotating stall operation varies considerably throughout the length of the compressor. The measured high-speed 10-stage test compressor individual stage pressure and temperature characteristics were input into a stage-by-stage dynamic compressor performance model. Comparison of the model results and measured pressures provided the additional validation necessary to demonstrate the model's ability to predict high-speed multistage compressor stalling and in-stall performance.« less

Investigation of Performance of Axial-Flow Compressor of XT-46 Turbine-Propeller Engine. II - Performance of Revised Compressor at Design Equivalent Speed. II; Performance of Revised Compressor at Design Equivalent Speed

NASA Technical Reports Server (NTRS)

Creagh, John W. R.

1950-01-01

The compressor from the XT-46 turbine-propeller engine was revised by removing the last two rows of stator blades and by eliminating the interstage leakage paths described in a previous report. With the revised compressor, the flow choking point shifted upstream into the last rotor-blade row but the maximum weight flow was not increased over that of the original compressor. The flow range of the revised compressor was reduced to about two-thirds that obtained with the original compressor. The later stages of the compressor did not produce the design static-pressure increase probably because of excessive boundary-layer build-up in this region. Measurements obtained in the ninth-stage stator showed that the performance up to this station was promising but that the last three stages of the compressor were limiting the useful operating range of the preceding stages. Some modifications in flow-passage geometry and blade settings are believed to be necessary, however, before any major improvements in over-all compressor performance can be obtained.

Performance Measurements and Mapping of a R-407C Vapor Injection Scroll Compressor

NASA Astrophysics Data System (ADS)

Lumpkin, Domenique; Spielbauer, Niklas; Groll, Eckhard

2017-08-01

Environmental conditions significantly define the performance of HVAC&R systems. Vapor compression systems in hot climates tend to operate at higher pressure ratios, leading to increased discharge temperatures. Higher discharge temperatures can lead to higher irreversibilities in the compression process, lower specific enthalpies differences across the evaporator, and possibly a reduction in the compressor life due to the breakdown of the oil used for lubrication. To counter these effects, the use of economized, vapor injection compressors is proposed for vapor compression systems in high temperature climates. Such compressors are commercially available for refrigeration applications, in particular, supermarket refrigeration systems. However, compressor maps for vapor injection compressors are limited and none exist for R-407C. Through calorimeter testing, a compressor map for a single-port vapor injection compressor using R-407C was developed. A standard correlation for mapping single-port vapor injection compressors is proposed and validated using the compressor test results. The system and compressor performance with and without vapor injection was considered. As expected, with vapor injection there was a reduction in compressor discharge temperatures and an increase in the system coefficient of performance. The proposed dimensionless correlation is more accurate than the AHRI polynomial for mapping the injection ratio, discharge temperature, and compressor heat loss. The predicted volumetric efficiency values from the dimensionless correlation is within 1% of the measured valued. Similarly, the predicted isentropic efficiency values are within 2% of the measured values.

Translation of incremental talk test responses to steady-state exercise training intensity.

PubMed

Lyon, Ellen; Menke, Miranda; Foster, Carl; Porcari, John P; Gibson, Mark; Bubbers, Terresa

2014-01-01

The Talk Test (TT) is a submaximal, incremental exercise test that has been shown to be useful in prescribing exercise training intensity. It is based on a subject's ability to speak comfortably during exercise. This study defined the amount of reduction in absolute workload intensity from an incremental exercise test using the TT to give appropriate absolute training intensity for cardiac rehabilitation patients. Patients in an outpatient rehabilitation program (N = 30) performed an incremental exercise test with the TT given every 2-minute stage. Patients rated their speech comfort after reciting a standardized paragraph. Anything other than a "yes" response was considered the "equivocal" stage, while all preceding stages were "positive" stages. The last stage with the unequivocally positive ability to speak was the Last Positive (LP), and the preceding stages were (LP-1 and LP-2). Subsequently, three 20-minute steady-state training bouts were performed in random order at the absolute workload at the LP, LP-1, and LP-2 stages of the incremental test. Speech comfort, heart rate (HR), and rating of perceived exertion (RPE) were recorded every 5 minutes. The 20-minute exercise training bout was completed fully by LP (n = 19), LP-1 (n = 28), and LP-2 (n = 30). Heart rate, RPE, and speech comfort were similar through the LP-1 and LP-2 tests, but the LP stage was markedly more difficult. Steady-state exercise training intensity was easily and appropriately prescribed at intensity associated with the LP-1 and LP-2 stages of the TT. The LP stage may be too difficult for patients in a cardiac rehabilitation program.

75 FR 39680 - Houston Pipe Line Company LP, Worsham-Steed Gas Storage, L.P., Energy Transfer Fuel, LP, Mid...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-12

... Company LP, Worsham-Steed Gas Storage, L.P., Energy Transfer Fuel, LP, Mid Continent Market Center, L.L.C... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PR10-44-000; Docket No. PR10... the protest or intervention to the Federal Energy Regulatory Commission, 888 First Street, NE...

Prevalence of Oral, Skin, and Oral and Skin Lesions of Lichen Planus in Patients Visiting a Dental School in Southern India

PubMed Central

Omal, PM; Jacob, Vimal; Prathap, Akhilesh; Thomas, Nebu George

2012-01-01

Background: Lichen planus (LP) is a mucocutaneous disease that is relatively common among adult population. LP can present as skin and oral lesions. This study highlights the prevalence of oral, skin, and oral and skin lesions of LP. Aims: The aim of this study was to evaluate the prevalence of oral, skin, and oral and skin lesions of LP from a population of patients attending the Department of Oral Medicine and Radiodiagnosis, Pushpagiri College of Dental Sciences, Tiruvalla, Kerala, India. Materials and Methods: A cross-sectional study was designed to evaluate the prevalence of oral, skin, and oral and skin lesions of LP. This is a ongoing prospective study with results of 2 years being reported. LP was diagnosed on the basis of clinical presentation and histopathological analysis of mucosal and skin biopsy done for all patients suspected of having LP. Statistical analysis was carried out using SPSS (Statistical package for social sciences) software version 14. To test the statistical significance, chi-square test was used. Results: Out of 18,306 patients screened, 8,040 were males and 10,266 females. LP was seen in 118 cases (0.64%). Increased prevalence of LP was observed in middle age adults (40–60 years age group) with lowest age of 12 years and highest age of 65 years. No statistically significant differences were observed between the genders in skin LP group (P=0.12) and in oral and skin LP groups (P=0.06); however, a strong female predilection was seen in oral LP group (P=0.000036). The prevalence of cutaneous LP in oral LP patients was 0.06%. Conclusion: This study showed an increased prevalence of oral LP than skin LP, and oral and skin LP with a female predominance. PMID:22615505

Three-dimensional Aerodynamic Instability in Multi-stage Axial Compressors

NASA Technical Reports Server (NTRS)

Suder, Kenneth (Technical Monitor); Tan, Choon-Sooi

2003-01-01

Four separate tasks are reported. The first task: A Computational Model for Short Wavelength Stall Inception and Development In Multi-Stage Compressors; the second task: Three-dimensional Rotating Stall Inception and Effects of Rotating Tip Clearance Asymmetry in Axial Compressors; the third task:Development of an Effective Computational Methodology for Body Force Representation of High-speed Rotor 37; and the fourth task:Development of Circumferential Inlet Distortion through a Representative Eleven Stage High-speed axial compressor. The common theme that threaded throughout these four tasks is the conceptual framework that consists of quantifying flow processes at the fadcompressor blade passage level to define the compressor performance characteristics needed for addressing physical phenomena such compressor aerodynamic instability and compressor response to flow distoriton with length scales larger than compressor blade-to-blade spacing at the system level. The results from these two levels can be synthesized to: (1) simulate compressor aerodynamic instability inception local to a blade rotor tip and its development from a local flow event into the nonlinear limit cycle instability that involves the entire compressor as was demonstrated in the first task; (2) determine the conditions under which compressor stability assessment based on two-dimensional model may not be adequate and the effects of self-induced flow distortion on compressor stability limit as in the second task; (3) quantify multistage compressor response to inlet distortion in stagnation pressure as illustrated in the fourth task; and (4) elucidate its potential applicability for compressor map generation under uniform as well as non-uniform inlet flow given three-dimensional Navier-Stokes solution for each individual blade row as was demonstrated in the third task.

Flow Range of Centrifugal Compressor Being Extended

NASA Technical Reports Server (NTRS)

Skoch, Gary J.

2001-01-01

General Aviation will benefit from turbine engines that are both fuel-efficient and reliable. Current engines fall short of their potential to achieve these attributes. The reason is compressor surge, which is a flow stability problem that develops when the compressor is subjected to conditions that are outside of its operating range. Compressor surge can occur when fuel flow to the engine is increased, temporarily back pressuring the compressor and pushing it past its stability limit, or when the compressor is subjected to inlet flow-field distortions that may occur during takeoff and landing. Compressor surge can result in the loss of an aircraft. As a result, engine designers include a margin of safety between the operating line of the engine and the stability limit line of the compressor. Unfortunately, the most efficient operating line for the compressor is usually closer to its stability limit line than it is to the line that provides an adequate margin of safety. A wider stable flow range will permit operation along the most efficient operating line of the compressor, improving the specific fuel consumption of the engine and reducing emissions. The NASA Glenn Research Center is working to extend the stable flow range of the compressor. Significant extension has been achieved in axial compressors by injecting air upstream of the compressor blade rows. Recently, the technique was successfully applied to a 4:1 pressure ratio centrifugal compressor by injecting streams of air into the diffuser. Both steady and controlled unsteady injection were used to inject air through the diffuser shroud surface and extend the range. Future work will evaluate the effect of air injection through the diffuser hub surface and diffuser vanes with the goal of maximizing the range extension while minimizing the amount of injected air that is required.

77 FR 58371 - Allegheny Hydro No. 8, L.P., Allegheny Hydro No. 9, L.P., and U.S. Bank National Association...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-20

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 3021-088] Allegheny Hydro No. 8, L.P., Allegheny Hydro No. 9, L.P., and U.S. Bank National Association Allegheny Hydro, LLC... 31, 2012, Allegheny Hydro No. 8, L.P., Allegheny Hydro No. 9, L.P., and U.S. Bank National...

Preliminary compressor design study for an advanced multistage axial flow compressor

NASA Technical Reports Server (NTRS)

Marman, H. V.; Marchant, R. D.

1976-01-01

An optimum, axial flow, high pressure ratio compressor for a turbofan engine was defined for commercial subsonic transport service starting in the late 1980's. Projected 1985 technologies were used and applied to compressors with an 18:1 pressure ratio having 6 to 12 stages. A matrix of 49 compressors was developed by statistical techniques. The compressors were evaluated by means of computer programs in terms of various airline economic figures of merit such as return on investment and direct-operating cost. The optimum configuration was determined to be a high speed, 8-stage compressor with an average blading aspect ratio of 1.15.

Design of a CO2 Twin Rotary Compressor for a Heat Pump Water Heater

NASA Astrophysics Data System (ADS)

Ahn, Jong Min; Kim, Woo Young; Kim, Hyun Jin; Cho, Sung Oug; Seo, Jong Cheun

2010-06-01

For a CO2 heat pump water heater, one-stage twin rotary compressor has been designed. As a design tool, computer simulation program for the compressor performance has been made. Validation of the simulation program has been carried out for a bench model compressor in a compressor calorimeter. Cooling capacity and the compressor input power were reasonably well compared between the simulation and the calorimeter test. Good agreement on P-V diagram between the simulation and the test was also obtained. With this validated compressor simulation program, parametric study has been performed to arrive at optimum dimensions for the compression chamber.

Device orientation of a leadless pacemaker and subcutaneous implantable cardioverter-defibrillator in canine and human subjects and the effect on intrabody communication.

PubMed

Quast, Anne-Floor B E; Tjong, Fleur V Y; Koop, Brendan E; Wilde, Arthur A M; Knops, Reinoud E; Burke, Martin C

2018-02-14

The development of communicating modular cardiac rhythm management systems relies on effective intrabody communication between a subcutaneous implantable cardioverter-defibrillator (S-ICD) and a leadless pacemaker (LP), using conducted communication. Communication success is affected by the LP and S-ICD orientation. This study is designed to evaluate the orientation of the LP and S-ICD in canine subjects and measure success and threshold of intrabody communication. To gain more human insights, we will explore device orientation in LP and S-ICD patients. Canine subjects implanted with a prototype S-ICD and LP (both Boston Scientific, MA, USA) with anterior-posterior fluoroscopy images were included in this analysis. For comparison, a retrospective analysis of human S-ICD and LP patients was performed. The angle of the long axis of the LP towards the vertical axis of 0°, and distance between the coil and LP were measured. Twenty-three canine subjects were analysed. Median angle of the LP was 29° and median distance of the S-ICD coil to LP was 0.8 cm. All canine subjects had successful communication. The median communicating threshold was 2.5 V. In the human retrospective analysis, 72 LP patients and 100 S-ICD patients were included. The mean angle of the LP was 56° and the median distance between the S-ICD coil and LP was 4.6 cm. Despite the less favourable LP orientation in canine subjects, all communication attempts were successful. In the human subjects, we observed a greater and in theory more favourable LP angle towards the communication vector. These data suggests suitability of human anatomy for conductive intrabody communication.

The design of a small linear-resonant, split Stirling cryogenic refrigerator compressor

NASA Technical Reports Server (NTRS)

Ackermann, R. A.

1985-01-01

The development of a small linear-resonant compressor for use in a 1/4-watt, 78K, split Stirling cryogenic refrigerator is discussed. The compressor contains the following special features: (1) a permanent-magnet linear motor; (2) resonant dynamics; (3) dynamic balancing; and (4) a close-clearance seal between the compressor piston and cylinder. This paper describes the design of the compressor, and presents component test data and system test data for the compressor driving a 1/4-watt expander.

PLC-based LP₁₁ mode rotator for mode-division multiplexing transmission.

PubMed

Saitoh, Kunimasa; Uematsu, Takui; Hanzawa, Nobutomo; Ishizaka, Yuhei; Masumoto, Kohei; Sakamoto, Taiji; Matsui, Takashi; Tsujikawa, Kyozo; Yamamoto, Fumihiko

2014-08-11

A PLC-based LP11 mode rotator is proposed. The proposed mode rotator is composed of a waveguide with a trench that provides asymmetry of the waveguide. Numerical simulations show that converting LP11a (LP11b) mode to LP11b (LP11a) mode can be achieved with high conversion efficiency (more than 90%) and little polarization dependence over a wide wavelength range from 1450 nm to 1650 nm. In addition, we fabricate the proposed LP11 mode rotator using silica-based PLC. It is confirmed that the fabricated mode rotator can convert LP11a mode to LP11b mode over a wide wavelength range.

Centrifugal compressor modifications and their effect on high-frequency pipe wall vibration

DOE Office of Scientific and Technical Information (OSTI.GOV)

Motriuk, R.W.; Harvey, D.P.

1998-08-01

High-frequency pulsation generated by centrifugal compressors, with pressure wave-lengths much smaller than the attached pipe diameter, can cause fatigue failures of the compressor internals, impair compressor performance, and damage the attached compressor piping. There are numerous sources producing pulsation in centrifugal compressors. Some of them are discussed in literature at large (Japikse, 1995; Niese, 1976). NGTL has experienced extreme high-frequency discharge pulsation and pipe wall vibration on many of its radial inlet high-flow centrifugal gas compressor facilities. These pulsations led to several piping attachment failures and compressor internal component failures while the compressor operated within the design envelope. This papermore » considers several pulsation conditions at an NGTL compression facility which resulted in unacceptable piping vibration. Significant vibration attenuation was achieved by modifying the compressor (pulsation source) through removal of the diffuser vanes and partial removal of the inlet guide vanes (IGV). Direct comparison of the changes in vibration, pulsation, and performance are made for each of the modifications. The vibration problem, probable causes, options available to address the problem, and the results of implementation are reviewed. The effects of diffuser vane removal on discharge pipe wall vibration as well as changes in compressor performance are described.« less

Performance Investigations of a Large Centrifugal Compressor from an Experimental Turbojet Engine

NASA Technical Reports Server (NTRS)

Ginsburg, Ambrose; Creagh, John W. R.; Ritter, William K.

1948-01-01

An investigation was conducted on a large centrifugal compressor from an experimental turbojet engine to determine the performance of the compressor and to obtain fundamental information on the aerodynamic problems associated with large centrifugal-type compressors. The results of the research conducted on the compressor indicated that the compressor would not meet the desired engine-design air-flow requirements (78 lb/sec) because of an air-flow restriction in the vaned collector (diffuser). Revision of the vaned collector resulted in an increased air-flow capacity over the speed range and showed improved matching of the impeller and diffuser components. At maximum flow, the original compressor utilized approximately 90 percent of the available geometric throat area at the vaned-collector inlet and the revised compressor utilized approximately 94 percent, regardless of impeller speed. The ratio of the maximum weight flows of the revised and original compressors were less than the ratio of effective critical throat areas of the two compressors because of the large pressure losses in the impeller near the impeller inelt and the difference increased with an increase in impeller speed. In order to further increase the pressure ratio and maximum weight flow of the compressor, the impeller must be modified to eliminate the pressure losses therein.

78 FR 55072 - Transcontinental Gas Pipe Line Company, LLC; Notice of Intent To Prepare an Environmental...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-09

... Project Transco proposes to add a new compressor unit to its existing Compressor Station 85 in Choctaw County, Alabama and up-rate an existing compressor unit at its existing Compressor Station 83 in Mobile... 225,000 dekatherms per day (dth/d) from Compressor Station 85 Receipt Points southward to the...

Experimental Studies on a Single Stage Stirling Type Pulse Tube Cryocooler Driven by Oil-Lubricated Compressor

NASA Astrophysics Data System (ADS)

Jia, Ren; Jianying, Hu; Ercang, Luo; Xiaotao, Wang

2010-04-01

Because lubricating oil for moving parts is not allowed to go into the pulse tube cryocooler, Stirling type pulse tube cryocoolers are generally driven by oil-free compressors although oil-lubricated compressors are much cheaper and facile. Recently, it was proposed that an acoustic transparent and oil blocking diaphragm could be employed to separate the compressor and the cryocooler. Thus, the cryocooler can be driven by oil-lubricated compressors. In this paper, a pulse tube cryocooler is designed to match a crankcase compressor. Although the efficiency of the crankcase compressor is lower compared with the oil-free linear compressor, the crankcase compressor can easily work at lower frequency which results in higher efficiency for the cryocooler. So the relative high performance of the whole system can be maintained. In this system, the cryocooler delivers 28.5 W of cooling at 80 K with 680 W of electrical input power and operates at 15 Hz. The corresponding Carnot efficiency is 11.52%.

Performance of Compressor of XJ-41-V Turbojet Engine. 4; Performance Analysis Over Range of Compressor Speeds from 5000 to 10,000 RPM

NASA Technical Reports Server (NTRS)

Creagh, John W. R.; Ginsburg, Ambrose

1948-01-01

An investigation of the XJ-41-V turbojet-engine compressor was conducted to determine the performance of the compressor and to obtain fundamental information on the aerodynamic problems associated with large centrifugal-type compressors. The results of the research conducted on the original compressor indicated the compressor would not meet the desired engine-design air-flow requirements because of an air-flow restriction in the vaned collector. The compressor air-flow choking point occurred near the entrance to the vaned-collector passage and was instigated by a poor mass-flow distribution at the vane entrance and from relatively large negative angles of attack of the air stream along the entrance edges of the vanes at the outer passage wall and large positive angles of attack at the inner passage wall. As a result of the analysis, a design change of the vaned collector entrance is recommended for improving the maximum flow capacity of the compressor.

Consideration of Sludge Formation in HFC-134a / Polyol Ester oil Refrigeration System

NASA Astrophysics Data System (ADS)

Yamamoto, Tsutomu; Yamamoto, Tethuya; Simizu, Yasuhiko; Nakayama, Yoshinori; Takizawa, Kikuo

A refrigeration test employing HFC-134a and polyol ester oil was carried out in order to make clear the causes of the sludge formation in the capillary tube. Compressors used were two types: a hermetic reciprocating compressor and a rotary compressor. Installed dryer contained desiccant of the compound zeolite type. The results showed that the amount of capillary sludge increased as the compressor temperature rose. The capillary sludge was determined to consist of desiccant and metal dust for the reciprocating compressor, and of tar-like substance for the rotary compressor. Thermal stability test which was used to check the degree of deterioration of the ester oil, suggested that the presence of desiccant and high compressor temperature might produce tar-like substance by the break down and polymerization of the ester oil. In addition, it was confirmed that factors affecting the sludge formation were the dirtiness of the refrigeration circuit for the reciprocating compressor, and the presence of desiccant, for the rotary compressor.

Comprehensive model of a hermetic reciprocating compressor

NASA Astrophysics Data System (ADS)

Yang, B.; Ziviani, D.; Groll, E. A.

2017-08-01

A comprehensive simulation model is presented to predict the performance of a hermetic reciprocating compressor and to reveal the underlying mechanisms when the compressor is running. The presented model is composed of sub-models simulating the in-cylinder compression process, piston ring/journal bearing frictional power loss, single phase induction motor and the overall compressor energy balance among different compressor components. The valve model, leakage through piston ring model and in-cylinder heat transfer model are also incorporated into the in-cylinder compression process model. A numerical algorithm solving the model is introduced. The predicted results of the compressor mass flow rate and input power consumption are compared to the published compressor map values. Future work will focus on detailed experimental validation of the model and parametric studies investigating the effects of structural parameters, including the stroke-to-bore ratio, on the compressor performance.

Effect of a curved duct upstream on performance of small centrifugal compressors for automobile turbochargers

NASA Astrophysics Data System (ADS)

Kikuchi, Shigeta; Yamasaki, Nobuhiko; Yamagata, Akihiro

2013-02-01

Since the automobile turbochargers are installed in an engine compartment with limited space, the ducts upstream of the turbocharger compressor may be curved in a complex manner. In the present paper, the effect of a curved duct upstream on performance of small centrifugal compressors for automobile turbochargers is discussed. The computational fluid dynamics (CFD) analysis of a turbocharger compressor validated for the compressor model with the straight pipe applied to the compressor with the curved pipe are executed, and the deterioration of the performance for the curved pipe is confirmed. It is also found that the deterioration of compressor performance is caused by the interaction of the secondary flow and the impeller.

Aerodynamic Design of Axial-flow Compressors. Volume III

NASA Technical Reports Server (NTRS)

Johnson, Irving A; Bullock, Robert O; Graham, Robert W; Costilow, Eleanor L; Huppert, Merle C; Benser, William A; Herzig, Howard Z; Hansen, Arthur G; Jackson, Robert J; Yohner, Peggy L;

Three-stage sorption type cryogenic refrigeration systems and methods employing heat regeneration

NASA Technical Reports Server (NTRS)

Bard, Steven (Inventor); Jones, Jack A. (Inventor)

1992-01-01

A three-stage sorption type cryogenic refrigeration system, each stage containing a fluid having a respectively different boiling point, is presented. Each stage includes a compressor in which a respective fluid is heated to be placed in a high pressure gaseous state. The compressor for that fluid which is heated to the highest temperature is enclosed by the other two compressors to permit heat to be transferred from the inner compressor to the surrounding compressors. The system may include two sets of compressors, each having the structure described above, with the interior compressors of the two sets coupled together to permit selective heat transfer therebetween, resulting in more efficient utilization of input power.

Temperature Swing Adsorption Compressor Development

NASA Technical Reports Server (NTRS)

Finn, John E.; Mulloth, Lila M.; Affleck, Dave L.

2001-01-01

Closing the oxygen loop in an air revitalization system based on four-bed molecular sieve and Sabatier reactor technology requires a vacuum pump-compressor that can take the low-pressure CO, from the 4BMS and compress and store for use by a Sabatier reactor. NASA Ames Research Center proposed a solid-state temperature-swing adsorption (TSA) compressor that appears to meet performance requirements, be quiet and reliable, and consume less power than a comparable mechanical compressor/accumulator combination. Under this task, TSA compressor technology is being advanced through development of a complete prototype system. A liquid-cooled TSA compressor has been partially tested, and the rest of the system is being fabricated. An air-cooled TSA compressor is also being designed.

Water injected fuel cell system compressor

DOEpatents

Siepierski, James S.; Moore, Barbara S.; Hoch, Martin Monroe

2001-01-01

A fuel cell system including a dry compressor for pressurizing air supplied to the cathode side of the fuel cell. An injector sprays a controlled amount of water on to the compressor's rotor(s) to improve the energy efficiency of the compressor. The amount of water sprayed out the rotor(s) is controlled relative to the mass flow rate of air inputted to the compressor.

Design of cladding rods-assisted depressed-core few-mode fibers with improved modal spacing

NASA Astrophysics Data System (ADS)

Han, Jiawei; Zhang, Jie

2018-03-01

This paper investigates the design details of cladding rods-assisted (CRA) depressed-core (DC) few-mode fibers (FMFs) that feature more equally spaced linearly polarized (LP) modal effective indices, suitable for high-spatial-density weakly-coupled mode-division multiplexing systems. The influences of the index profile of cladding rods on LP mode-resolved effective index, bending sensitivity, and effective area Aeff, are numerically described. Based on the design considerations of LP modal Aeff-dependent spatial efficiency and LP modal bending loss-dependent robustness, the small LP21-LP02 and LP22-LP03 modal spacing limitations, encountered in state-of-the-art weakly-coupled step-index FMFs, have been substantially improved by at least 25%. In addition, the proposed CRA DC FMFs also show sufficiently large effective areas (in excess of 110 μm2) for all guided LP modes, which are expected to exhibit good nonlinear performance.

Fuzzy linear model for production optimization of mining systems with multiple entities

NASA Astrophysics Data System (ADS)

Vujic, Slobodan; Benovic, Tomo; Miljanovic, Igor; Hudej, Marjan; Milutinovic, Aleksandar; Pavlovic, Petar

2011-12-01

Planning and production optimization within multiple mines or several work sites (entities) mining systems by using fuzzy linear programming (LP) was studied. LP is the most commonly used operations research methods in mining engineering. After the introductory review of properties and limitations of applying LP, short reviews of the general settings of deterministic and fuzzy LP models are presented. With the purpose of comparative analysis, the application of both LP models is presented using the example of the Bauxite Basin Niksic with five mines. After the assessment, LP is an efficient mathematical modeling tool in production planning and solving many other single-criteria optimization problems of mining engineering. After the comparison of advantages and deficiencies of both deterministic and fuzzy LP models, the conclusion presents benefits of the fuzzy LP model but is also stating that seeking the optimal plan of production means to accomplish the overall analysis that will encompass the LP model approaches.

Selective excitation of LP01 and LP02 in dual-concentric cores fiber using an adiabatically tapered microstructured mode converter

NASA Astrophysics Data System (ADS)

Sammouda, Marwa; Taher, Aymen Belhadj; Bahloul, Faouzi; Bin, Philippe Di

2016-09-01

We propose to connect a single-mode fiber (SMF) to a dual-concentric cores fiber (DCCF) using an adiabatically tapered microstructured mode converter, and to evaluate the SMF LP01 mode and the DCCF LP01 and LP02 modes selective excitations performances. We theoretically and numerically study this selective excitation method by calculating the effective indices of the propagated modes, the adiabaticity criteria, the coupling loss, and the modes amplitudes along the tapered structure. This study shows that this method is able to achieve excellent selective excitations of the first two linearly polarized modes (LP01 and LP02) among the five guided modes in the DCCF with a negligible loss. The part of the LP01 and LP02 modes from the total power are 99% and 84% corresponding to 0.1 and 0.8 dB losses, respectively.

Immunogenicity of recombinant Lactobacillus casei-expressing F4 (K88) fimbrial adhesin FaeG in conjunction with a heat-labile enterotoxin A (LTAK63) and heat-labile enterotoxin B (LTB) of enterotoxigenic Escherichia coli as an oral adjuvant in mice.

PubMed

Yu, M; Qi, R; Chen, C; Yin, J; Ma, S; Shi, W; Wu, Y; Ge, J; Jiang, Y; Tang, L; Xu, Y; Li, Y

2017-02-01

The aims of this study were to develop an effective oral vaccine against enterotoxigenic Escherichia coli (ETEC) infection and to design new and more versatile mucosal adjuvants. Genetically engineered Lactobacillus casei strains expressing F4 (K88) fimbrial adhesin FaeG (rLpPG-2-FaeG) and either co-expressing heat-labile enterotoxin A (LTA) subunit with an amino acid mutation associated with reduced virulence (LTAK63) and a heat-labile enterotoxin B (LTB) subunit of E. coli (rLpPG-2-LTAK63-co-LTB) or fused-expressing LTAK63 and LTB (rLpPG-2-LTAK63-fu-LTB) were constructed. The immunogenicity of rLpPG-2-FaeG in conjunction with rLpPG-2-LTAK63-co-LTB or rLpPG-2-LTAK63-fu-LTB as an orally administered mucosal adjuvant in mice was evaluated. Results showed that the levels of FaeG-specific serum IgG and mucosal sIgA, as well as the proliferation of lymphocytes, were significantly higher in mice orally co-administered rLpPG-2-FaeG and rLpPG-2-LTAK63-fu-LTB compared with those administered rLpPG-2-FaeG alone, and were lower than those co-administered rLpPG-2-FaeG and rLpPG-2-LTAK63-co-LTB. Moreover, effective protection was observed after challenge with F4+ ETEC strain CVCC 230 in mice co-administered rLpPG-2-FaeG and rLpPG-2-LTAK63-co-LTB or rLpPG-2-FaeG and rLpPG-2-LTAK63-fu-LTB group compared with those that received rLpPG-2-FaeG alone. rLpPG-2-FaeG showed greater immunogenicity in combination with LTAK63 and LTB as molecular adjuvants. Recombinant Lactobacillus provides a promising platform for the development of vaccines against F4+ ETEC infection. © 2016 The Society for Applied Microbiology.

A comparison of self-report and direct observation of booster seat use in Latino families.

PubMed

Quistberg, D Alex; Lozano, Paula; Mack, Christopher D; Schwartz, Rachel; Ebel, Beth E

2010-08-01

To develop a reliable self-report tool for measuring child booster seat use among Latino families. Cross-sectional and observational survey of a convenience sample. Five retail stores in King County, Washington. 50 parents of children 4-8 years old that self-identified as Latino or Hispanic. Parent-reported measures of how often the child uses a booster seat, if the child used a booster seat on the last trip, how often the child complains about using a booster seat, how often the child asks to not use a booster seat, and how often other families they know use a booster seat. Observed booster seat use by child. 26 children (52%) were observed using a booster seat. Parent-reported booster seat use was a poor predictor of observed booster seat use. Although 34 parents reported that their child 'always' uses a booster seat, 8 (24%) of these children were not using a booster seat. A logistic model to predict booster seat use had a sensitivity of 81% and a specificity of 71%, and misclassified 24% of the participants' observed use. Reliance on parent-reported booster seat use significantly overstated observed booster seat use in the study. Among this study population, accurate determination of booster seat use required direct observation.

Stall/surge dynamics of a multi-stage air compressor in response to a load transient of a hybrid solid oxide fuel cell-gas turbine system

NASA Astrophysics Data System (ADS)

Azizi, Mohammad Ali; Brouwer, Jacob

2017-10-01

A better understanding of turbulent unsteady flows in gas turbine systems is necessary to design and control compressors for hybrid fuel cell-gas turbine systems. Compressor stall/surge analysis for a 4 MW hybrid solid oxide fuel cell-gas turbine system for locomotive applications is performed based upon a 1.7 MW multi-stage air compressor. Control strategies are applied to prevent operation of the hybrid SOFC-GT beyond the stall/surge lines of the compressor. Computational fluid dynamics tools are used to simulate the flow distribution and instabilities near the stall/surge line. The results show that a 1.7 MW system compressor like that of a Kawasaki gas turbine is an appropriate choice among the industrial compressors to be used in a 4 MW locomotive SOFC-GT with topping cycle design. The multi-stage radial design of the compressor enhances the ability of the compressor to maintain air flow rate during transient step-load changes. These transient step-load changes are exhibited in many potential applications for SOFC/GT systems. The compressor provides sustained air flow rate during the mild stall/surge event that occurs due to the transient step-load change that is applied, indicating that this type of compressor is well-suited for this hybrid application.

Effects of high-fat diet on somatic growth, metabolic parameters and function of peritoneal macrophages of young rats submitted to a maternal low-protein diet.

PubMed

Alheiros-Lira, Maria Cláudia; Jurema-Santos, Gabriela Carvalho; da-Silva, Helyson Tomaz; da-Silva, Amanda Cabral; Moreno Senna, Sueli; Ferreira E Silva, Wylla Tatiana; Ferraz, José Candido; Leandro, Carol Góis

2017-03-01

This study evaluated the effects of a post-weaning high-fat (HF) diet on somatic growth, food consumption, metabolic parameters, phagocytic rate and nitric oxide (NO) production of peritoneal macrophages in young rats submitted to a maternal low-protein (LP) diet. Male Wistar rats (aged 60 d) were divided in two groups (n 22/each) according to their maternal diet during gestation and lactation: control (C, dams fed 17 % casein) and LP (dams fed 8 % casein). At weaning, half of the groups were fed HF diet and two more groups were formed (HF and low protein-high fat (LP-HF)). Somatic growth, food and energy intake, fat depots, serum glucose, cholesterol and leptin concentrations were evaluated. Phagocytic rate and NO production were analysed in peritoneal macrophages under stimulation of zymosan and lipopolysaccharide (LPS)+interferon γ (IFN-γ), respectively. The maternal LP diet altered the somatic parameters of growth and development of pups. LP and LP-HF pups showed a higher body weight gain and food intake than C pups. HF and LP-HF pups showed increased retroperitoneal and epididymal fat depots, serum level of TAG and total cholesterol compared with C and LP pups. After LPS+IFN-γ stimulation, LP and LP-HF pups showed reduced NO production when compared with their pairs. Increased phagocytic activity and NO production were seen in LP but not LP-HF peritoneal macrophages. However, peritoneal macrophages of LP pups were hyporesponsive to LPS+IFN-γ induced NO release, even after a post-weaning HF diet. Our data demonstrated that there was an immunomodulation related to dietary fatty acids after the maternal LP diet-induced metabolic programming.

Dimension Determination of Precursive Stall Events in a Single Stage High Speed Compressor

NASA Technical Reports Server (NTRS)

Bright, Michelle M.; Qammar, Helen K.; Hartley, Tom T.

1996-01-01

This paper presents a study of the dynamics for a single-stage, axial-flow, high speed compressor core, specifically, the NASA Lewis rotor stage 37. Due to the overall blading design for this advanced core compressor, each stage has considerable tip loading and higher speed than most compressor designs, thus, the compressor operates closer to the stall margin. The onset of rotating stall is explained as bifurcations in the dynamics of axial compressors. Data taken from the compressor during a rotating stall event is analyzed. Through the use of a box-assisted correlation dimension methodology, the attractor dimension is determined during the bifurcations leading to rotating stall. The intent of this study is to examine the behavior of precursive stall events so as to predict the entrance into rotating stall. This information may provide a better means to identify, avoid or control the undesirable event of rotating stall formation in high speed compressor cores.

A modeling study of a centrifugal compressor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Popovic, P.; Shapiro, H.N.

1998-12-31

A centrifugal compressor, which is part of a chlorofluorocarbon R-114 chiller installation, was investigated, operating with a new refrigerant, hydrofluorocarbon R-236ea, a proposed alternative to R-114. A large set of R-236ea operating data, as well as a limited amount of R-114 data, were available for this study. A relatively simple analytical compressor model was developed to describe compressor performance. The model was built upon a thorough literature search, experimental data, and some compressor design parameters. Two original empirical relations were developed, providing a new approach to the compressor modeling. The model was developed in a format that would permit itmore » to be easily incorporated into a complete chiller simulation. The model was found to improve somewhat on the quantitative and physical aspects of a compressor model of the same format found in the literature. It was found that the compressor model is specific to the particular refrigerant.« less

Fault detection and diagnosis for refrigerator from compressor sensor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Keres, Stephen L.; Gomes, Alberto Regio; Litch, Andrew D.

A refrigerator, a sealed refrigerant system, and method are provided where the refrigerator includes at least a refrigerated compartment and a sealed refrigerant system including an evaporator, a compressor, a condenser, a controller, an evaporator fan, and a condenser fan. The method includes monitoring a frequency of the compressor, and identifying a fault condition in the at least one component of the refrigerant sealed system in response to the compressor frequency. The method may further comprise calculating a compressor frequency rate based upon the rate of change of the compressor frequency, wherein a fault in the condenser fan is identifiedmore » if the compressor frequency rate is positive and exceeds a condenser fan fault threshold rate, and wherein a fault in the evaporator fan is identified if the compressor frequency rate is negative and exceeds an evaporator fan fault threshold rate.« less

Impact of the electric compressor for automotive air conditioning system on fuel consumption and performance analysis

NASA Astrophysics Data System (ADS)

Zulkifli, A. A.; Dahlan, A. A.; Zulkifli, A. H.; Nasution, H.; Aziz, A. A.; Perang, M. R. M.; Jamil, H. M.; Misseri, M. N.

2015-12-01

Air conditioning system is the biggest auxiliary load in a vehicle where the compressor consumed the largest. Problem with conventional compressor is the cooling capacity cannot be control directly to fulfill the demand of thermal load inside vehicle cabin. This study is conducted experimentally to analyze the difference of fuel usage and air conditioning performance between conventional compressor and electric compressor of the air conditioning system in automobile. The electric compressor is powered by the car battery in non-electric vehicle which the alternator will recharge the battery. The car is setup on a roller dynamometer and the vehicle speed is varied at 0, 30, 60, 90 and 110 km/h at cabin temperature of 25°C and internal heat load of 100 and 400 Watt. The results shows electric compressor has better fuel consumption and coefficient of performance compared to the conventional compressor.

Core compressor exit stage study. 1: Aerodynamic and mechanical design

NASA Technical Reports Server (NTRS)

Burdsall, E. A.; Canal, E., Jr.; Lyons, K. A.

1979-01-01

The effect of aspect ratio on the performance of core compressor exit stages was demonstrated using two three stage, highly loaded, core compressors. Aspect ratio was identified as having a strong influence on compressors endwall loss. Both compressors simulated the last three stages of an advanced eight stage core compressor and were designed with the same 0.915 hub/tip ratio, 4.30 kg/sec (9.47 1bm/sec) inlet corrected flow, and 167 m/sec (547 ft/sec) corrected mean wheel speed. The first compressor had an aspect ratio of 0.81 and an overall pressure ratio of 1.357 at a design adiabatic efficiency of 88.3% with an average diffusion factor or 0.529. The aspect ratio of the second compressor was 1.22 with an overall pressure ratio of 1.324 at a design adiabatic efficiency of 88.7% with an average diffusion factor of 0.491.

Lp-dual affine surface area

NASA Astrophysics Data System (ADS)

Wei, Wang; Binwu, He

2008-12-01

According to the notion of Lp-affine surface area by Lutwak, in this paper, we introduce the concept of Lp-dual affine surface area. Further, we establish the affine isoperimetric inequality and the Blaschke-Santaló inequality for Lp-dual affine surface area. Besides, the dual Brunn-Minkowski inequality for Lp-dual affine surface area is presented.

Preliminary design study of advanced multistage axial flow core compressors

NASA Technical Reports Server (NTRS)

Wisler, D. C.; Koch, C. C.; Smith, L. H., Jr.

1977-01-01

A preliminary design study was conducted to identify an advanced core compressor for use in new high-bypass-ratio turbofan engines to be introduced into commercial service in the 1980's. An evaluation of anticipated compressor and related component 1985 state-of-the-art technology was conducted. A parametric screening study covering a large number of compressor designs was conducted to determine the influence of the major compressor design features on efficiency, weight, cost, blade life, aircraft direct operating cost, and fuel usage. The trends observed in the parametric screening study were used to develop three high-efficiency, high-economic-payoff compressor designs. These three compressors were studied in greater detail to better evaluate their aerodynamic and mechanical feasibility.

Stage-by-Stage and Parallel Flow Path Compressor Modeling for a Variable Cycle Engine

NASA Technical Reports Server (NTRS)

Kopasakis, George; Connolly, Joseph W.; Cheng, Larry

2015-01-01

This paper covers the development of stage-by-stage and parallel flow path compressor modeling approaches for a Variable Cycle Engine. The stage-by-stage compressor modeling approach is an extension of a technique for lumped volume dynamics and performance characteristic modeling. It was developed to improve the accuracy of axial compressor dynamics over lumped volume dynamics modeling. The stage-by-stage compressor model presented here is formulated into a parallel flow path model that includes both axial and rotational dynamics. This is done to enable the study of compressor and propulsion system dynamic performance under flow distortion conditions. The approaches utilized here are generic and should be applicable for the modeling of any axial flow compressor design.

Field testing energy-saving hermetic compressors in residential refrigerators

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sauber, R.S.; Middleton, M.G.

The design of an energy-saving compressor for low back pressure applications is reviewed. Calorimeter performance results are stated for two sizes of the efficient design and compared with performance test results for a standard compressor. Power consumption of a refrigerator-freezer is given with a standard compressor and with the energy-saving compressor. The preparation of the refrigerators used in the field test is discussed, along with the criteria used in selecting the instrumentation for the project. Results of the energy-saving compressor in the field test, along with a comparison to a standard production compressor, are presented. Some conclusions are drawn, basedmore » on the data, in relation to important factors in residential refrigerator power consumption.« less

Field testing energy-saving hermetic compressors in residential refrigerators

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sauber, R.S.; Middleton, M.G.

The design of an energy saving compressor for low back pressure applications is reviewed. Calorimeter performance results are stated for two sizes of the efficient design and compared with performance test results for a standard compressor. Power consumption of a refrigerator-freezer is given with a standard compressor and with the energy saving compressor. The preparation of the refrigerators used in the field test are discussed along with the criteria used in selecting the instrumentation for the project. Results of the energy saving compressor in the field test along with a comparison to a standard production compressor are presented. Some conclusionsmore » are drawn, based on the data, in relation to important factors in residential refrigerator power consumption.« less

Trends in high performance compressors for petrochemical and natural gas industry in China

NASA Astrophysics Data System (ADS)

Zhao, Yuanyang; Li, Liansheng

2015-08-01

Compressors are the key equipment in the petrochemical and natural gas industry system. The performance and reliability of them are very important for the process system. The application status of petrochemical & natural gas compressors in China is presented in this paper. The present status of design and operating technologies of compressors in China are mentioned in this paper. The turbo, reciprocating and twin screw compressors are discussed. The market demands for different structure compressors in process gas industries are analysed. This paper also introduces the research and developments for high performance compressors in China. The recent research results on efficiency improvement methods, stability improvement, online monitor and fault diagnosis will also be presented in details.

Impact of Apolipoprotein(a) Isoform Size on Lipoprotein(a) Lowering in the HPS2-THRIVE Study

PubMed Central

Hopewell, Jemma C.; Hill, Michael R.; Marcovina, Santica; Valdes-Marquez, Elsa; Haynes, Richard; Offer, Alison; Pedersen, Terje R.; Baigent, Colin; Collins, Rory; Landray, Martin; Armitage, Jane

2018-01-01

Background: Genetic studies have shown lipoprotein(a) (Lp[a]) to be an important causal risk factor for coronary disease. Apolipoprotein(a) isoform size is the chief determinant of Lp(a) levels, but its impact on the benefits of therapies that lower Lp(a) remains unclear. Methods: HPS2-THRIVE (Heart Protection Study 2–Treatment of HDL to Reduce the Incidence of Vascular Events) is a randomized trial of niacin–laropiprant versus placebo on a background of simvastatin therapy. Plasma Lp(a) levels at baseline and 1 year post-randomization were measured in 3978 participants from the United Kingdom and China. Apolipoprotein(a) isoform size, estimated by the number of kringle IV domains, was measured by agarose gel electrophoresis and the predominantly expressed isoform identified. Results: Allocation to niacin–laropiprant reduced mean Lp(a) by 12 (SE, 1) nmol/L overall and 34 (6) nmol/L in the top quintile by baseline Lp(a) level (Lp[a] ≥128 nmol/L). The mean proportional reduction in Lp(a) with niacin–laropiprant was 31% but varied strongly with predominant apolipoprotein(a) isoform size (PTrend=4×10−29) and was only 18% in the quintile with the highest baseline Lp(a) level and low isoform size. Estimates from genetic studies suggest that these Lp(a) reductions during the short term of the trial might yield proportional reductions in coronary risk of ≈2% overall and 6% in the top quintile by Lp(a) levels. Conclusions: Proportional reductions in Lp(a) were dependent on apolipoprotein(a) isoform size. Taking this into account, the likely benefits of niacin–laropiprant on coronary risk through Lp(a) lowering are small. Novel therapies that reduce high Lp(a) levels by at least 80 nmol/L (≈40%) may be needed to produce worthwhile benefits in people at the highest risk because of Lp(a). Clinical Trial Registration: URL: https://clinicaltrials.gov. Unique identifier: NCT00461630. PMID:29449329

46 CFR 154.1415 - Air compressor.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 5 2013-10-01 2013-10-01 false Air compressor. 154.1415 Section 154.1415 Shipping COAST... Equipment § 154.1415 Air compressor. Each vessel must have an air compressor to recharge the bottles for the air-breathing apparatus. ...

46 CFR 154.1415 - Air compressor.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 5 2012-10-01 2012-10-01 false Air compressor. 154.1415 Section 154.1415 Shipping COAST... Equipment § 154.1415 Air compressor. Each vessel must have an air compressor to recharge the bottles for the air-breathing apparatus. ...

46 CFR 154.1415 - Air compressor.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 5 2014-10-01 2014-10-01 false Air compressor. 154.1415 Section 154.1415 Shipping COAST... Equipment § 154.1415 Air compressor. Each vessel must have an air compressor to recharge the bottles for the air-breathing apparatus. ...

46 CFR 154.1415 - Air compressor.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 5 2010-10-01 2010-10-01 false Air compressor. 154.1415 Section 154.1415 Shipping COAST... Equipment § 154.1415 Air compressor. Each vessel must have an air compressor to recharge the bottles for the air-breathing apparatus. ...

46 CFR 154.1415 - Air compressor.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 5 2011-10-01 2011-10-01 false Air compressor. 154.1415 Section 154.1415 Shipping COAST... Equipment § 154.1415 Air compressor. Each vessel must have an air compressor to recharge the bottles for the air-breathing apparatus. ...

Compressor Study to Meet Large Civil Tilt Rotor Engine Requirements

NASA Technical Reports Server (NTRS)

Veres, Joseph P.

2009-01-01

A vehicle concept study has been made to meet the requirements of the Large Civil Tilt Rotorcraft vehicle mission. A vehicle concept was determined, and a notional turboshaft engine system study was conducted. The engine study defined requirements for the major engine components, including the compressor. The compressor design-point goal was to deliver a pressure ratio of 31:1 at an inlet weight flow of 28.4 lbm/sec. To perform a conceptual design of two potential compressor configurations to meet the design requirement, a mean-line compressor flow analysis and design code were used. The first configuration is an eight-stage axial compressor. Some challenges of the all-axial compressor are the small blade spans of the rear-block stages being 0.28 in., resulting in the last-stage blade tip clearance-to-span ratio of 2.4%. The second configuration is a seven-stage axial compressor, with a centrifugal stage having a 0.28-in. impeller-exit blade span. The compressors conceptual designs helped estimate the flow path dimensions, rotor leading and trailing edge blade angles, flow conditions, and velocity triangles for each stage.

Compressor Study to Meet Large Civil Tilt Rotor Engine Requirements

NASA Technical Reports Server (NTRS)

Veres, Joseph P.

2009-01-01

A vehicle concept study has been made to meet the requirements of the Large Civil Tilt Rotorcraft vehicle mission. A vehicle concept was determined, and a notional turboshaft engine system study was conducted. The engine study defined requirements for the major engine components, including the compressor. The compressor design-point goal was to deliver a pressure ratio of 31:1 at an inlet weight flow of 28.4 lbm/sec. To perform a conceptual design of two potential compressor configurations to meet the design requirement, a mean-line compressor flow analysis and design code were used. The first configuration is an eight-stage axial compressor. Some challenges of the all-axial compressor are the small blade spans of the rear-block stages being 0.28 in., resulting in the last-stage blade tip clearance-to-span ratio of 2.4 percent. The second configuration is a seven-stage axial compressor, with a centrifugal stage having a 0.28-in. impeller-exit blade span. The compressors conceptual designs helped estimate the flow path dimensions, rotor leading and trailing edge blade angles, flow conditions, and velocity triangles for each stage.

Influence of Lewy Pathology on Alzheimer's Disease Phenotype: A Retrospective Clinico-Pathological Study.

PubMed

Roudil, Jennifer; Deramecourt, Vincent; Dufournet, Boris; Dubois, Bruno; Ceccaldi, Mathieu; Duyckaerts, Charles; Pasquier, Florence; Lebouvier, Thibaud

2018-01-01

Studies have shown the frequent coexistence of Lewy pathology (LP) in Alzheimer's Disease (AD). The aim of this study was to determine the influence of LP on the clinical and cognitive phenotype in a cohort of patients with a neuropathological diagnosis of AD. We reviewed neuropathologically proven AD cases, reaching Braak stages V and VI in the brain banks of Lille and Paris between 1993 and 2016, and classified them according to LP extension (amygdala, brainstem, limbic, or neocortical). We then searched patient files for all available clinical and neuropsychiatric features and neuropsychological data. Thirty-three subjects were selected for this study, among which 16 were devoid of LP and 17 presented AD with concomitant LP. The latter were stratified into two subgroups according to LP distribution: 7 were AD with amygdala LP and 10 were AD with 'classical' (brainstem, limbic or neocortical) LP. When analyzing the incidence of each clinical feature at any point during the disease course, we found no significant difference in symptom frequency between the three groups. However, fluctuations appeared significantly earlier in patients with classical LP (2±3.5 years) than in patients without LP (7±1.7 years) or with amygdala LP (8±2.8 years; p < 0.01). There was no significant difference in cognitive profiles. Our findings suggest that the influence of LP on the clinical phenotype of AD is subtle. Core features of dementia with Lewy bodies do not allow clinical diagnosis of a concomitant LP on a patient-to-patient basis.

Investigation of TESCOM Driveshaft Assembly Failure

DTIC Science & Technology

1998-10-01

ratio, two-stage axial -flow compressor with a corrected tip speed of 1250 ft/sec at design . The flowpath casing diameter downstream of the inlet... Design of a 1250 ft/sec. Low-Aspect-Ratio, Single-Stage Axial -Flow Compressor , AFAPL-TR-79-2096, Air Force Aero Propulsion Laboratory, Wright...The TESCOM compressor described in this report is a 2.5-stage, low aspect ratio, axial -flow compressor . The performance objectives of this compressor

Development of a J-T Micro Compressor

NASA Astrophysics Data System (ADS)

Champagne, P.; Olson, J. R.; Nast, T.; Roth, E.; Collaco, A.; Kaldas, G.; Saito, E.; Loung, V.

2015-12-01

Lockheed Martin has developed and tested a space-quality compressor capable of delivering closed-loop gas flow with a high pressure ratio, suitable for driving a Joule- Thomson cold head. The compressor is based on a traditional “Oxford style” dual-opposed piston compressor with linear drive motors and flexure-bearing clearance-seal technology for high reliability and long life. This J-T compressor retains the approximate size, weight, and cost of the ultra-compact, 200 gram Lockheed Martin Pulse Tube Micro Compressor, despite the addition of a flow-rectifying system to convert the AC pressure wave into a steady flow.

77 FR 59393 - Jordan Cove Energy Project LP; Pacific Connector Gas Pipeline LP; Notice of Additional Public...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-27

...-17-000] Jordan Cove Energy Project LP; Pacific Connector Gas Pipeline LP; Notice of Additional Public..., and 11, 2012, the Federal Energy Regulatory Commission (FERC or Commission) Office of Energy Projects... additional public scoping meetings to take comments on Jordan Cove Energy Project LP's (Jordan Cove) proposed...

77 FR 61753 - Granting of Request for Early Termination of the Waiting Period Under the Premerger Notification...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-11

..., Inc.; Astria Semiconductor Holdings, Inc.; FormFactor, Inc. 20121365 G ABRY Partners VII, L.P.; Source.... 20121303 G Wind Point Partners L.P.; Mistral Equity Partners, LP; Wind Point Partners VII-A, L.P. 20121307... Dillard. 20121364 G Apollo Investment Fund VII, L.P.; Jimmy Sanders Incorporated; Apollo Investment Fund...

Extended range heat pump system and centrifugal compressor for use therewith

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shoemaker, J.F.

1988-04-26

Improvements in heat pump systems having indoor and outdoor heat exchangers and at least two compressors for supplying a refrigerant medium under pressure thereto, and means for circulating the medium through the heat exchangers, the improvement is described comprising a selector valve associated with each of the compressors. The selector valves provide that any combination and any one or more of the compressors can be selected for operation, each of the selector valves having a first operating condition placing the associated compressor in series with the heat exchangers and a second operating condition whereby the associated compressor is bypassed, whenmore » the selector valves for at least two of the compressors are simultaneously in their first positions a flow path is established through the associated compressors and through the heat exchangers all in series, a two position changeover valve and associated conduit means. The changeover valve has a first position wherein at least one of the compressors is connected in series with the first and second heat exchangers to produce flow of the medium in one direction therethrough and a second position whereby at least one compressor is connected to produce flow of the medium in the opposite direction through the heat exchangers.« less

Vapor cycle cooling system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Midolo, L.

1980-07-08

A description is given of a rotary vane cooling system including a two phase coolant, comprising: a vaporizable liquid working medium within said cooling system; an evaporator having an inlet and an outlet; a condenser having an inlet and an outlet; a two stage rotary vane compressor, including means for connecting the outlet of a first compressor stage to the inlet of a second compressor stage; said two stage rotary vane compressor being connected between the outlet of said evaporator and the inlet at said condenser; an expansion device connected between the outlet of said condenser and the inlet ofmore » said evaporator; said two stage compressor including a housing having a chamber therein, a rotor on a rotatable shaft; said rotor being positioned within said chamber; said rotor having a plurality of slidable vanes which form a plurality of cells, within said chamber, which change in volume as the rotor rotates; said plurality of cells including a pluraity of cells on one side of said rotor which corresponds to said first compressor stage and a plurality of cells on the other side of said rotor which corresponds to said second compressor stage; said cells corresponding to said first compressor stage having a greater maximum volume than the cells corresponding to said second compressor stage; and means for supplying at least a portion of the vapor resulting from the expansion in said expansion device to the inlet of the second compressor stage for providing cooling in the inlet of said second compressor stage.« less

Novel Long Stroke Reciprocating Compressor for Energy Efficient Jaggery Making

NASA Astrophysics Data System (ADS)

Rane, M. V.; Uphade, D. B.

2017-08-01

Novel Long Stroke Reciprocating Compressor is analysed for jaggery making while avoiding burning of bagasse for concentrating juice. Heat of evaporated water vapour along with small compressor work is recycled to enable boiling of juice. Condensate formed during heating of juice is pure water, as oil-less compressor is used. Superheat of compressor is suppressed by flow of superheated vapours through condensate. It limits heating surface temperature and avoids caramelization of sugar. Thereby improves quality of jaggery and eliminates need to use chemicals for colour improvement. Stroke to bore ratio is 0.6 to 1.2 in conventional reciprocating drives. Long stroke in reciprocating compressors enhances heat dissipation to surrounding by providing large surface area and increases isentropic efficiency by reducing compressor outlet temperature. Longer stroke increases inlet and exit valve operation timings, which reduces inertial effects substantially. Thereby allowing use of sturdier valves. This enables handling liquid along with vapour in compressors. Thereby supressing the superheat and reducing compressor power input. Longer stroke increases stroke to clearance ratios which increases volumetric efficiency and ability of compressor to compress through higher pressure ratios efficiently. Stress-strain simulation is performed in SolidWorks for gear drive. Long Stroke Reciprocating Compressor is developed at Heat Pump Laboratory, stroke/bore 292 mm/32 mm. It is operated and tested successfully at different speeds for operational stability of components. Theoretical volumetric efficiency is 93.9% at pressure ratio 2.0. Specific energy consumption is 108.3 kWhe/m3 separated water, considering free run power.

The presence of lysylpyridinoline in the hypertrophic cartilage of newly hatched chicks

NASA Technical Reports Server (NTRS)

Orth, M. W.; Martinez, D. A.; Cook, M. E.; Vailas, A. C.

1993-01-01

The presence of lysylpyridinoline (LP) as a nonreducible cross-link in appreciable quantities has primarily been limited to the mineralized tissues, bone and dentin. However, the results reported here show that LP is not only present in the hypertrophic cartilage of the tibiotarsus isolated from newly hatched broiler chicks, but it is approx. 4-fold as concentrated as hydroxylysylpyridinoline (HP). Bone and articular cartilage surrounding the hypertrophic cartilage do not contain measurable quantities of LP. Purified LP has a fluorescent scan similar to purified HP and literature values, confirming that we indeed were measuring LP. Also, the cartilage lesion produced by immature chondrocytes from birds with tibial dyschondroplasia had LP but the HP:LP ratio was > 1. Thus, the low HP:LP ratio could be a marker for hypertrophic cartilage in avians.

40 CFR 204.55-3 - Configuration identification.

Code of Federal Regulations, 2010 CFR

2010-07-01

... PROGRAMS NOISE EMISSION STANDARDS FOR CONSTRUCTION EQUIPMENT Portable Air Compressors § 204.55-3... the following parameters: (1) The compressor type (screw, sliding vane, etc.). (2) Number of compressor stages. (3) Maximum pressure (psi). (4) Air intake system of compressor: (i) Number of filters...

ETR COMPRESSOR BUILDING, TRA643. COMPRESSORS AND OTHER EQUIPMENT INSTALLED. METAL ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

ETR COMPRESSOR BUILDING, TRA-643. COMPRESSORS AND OTHER EQUIPMENT INSTALLED. METAL ROOF AND CONCRETE BLOCK WALLS. INL NEGATIVE NO. 61-4536. Unknown Photographer, ca. 1961. - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

Stator Indexing in Multistage Compressors

NASA Technical Reports Server (NTRS)

Barankiewicz, Wendy S.

1997-01-01

The relative circumferential location of stator rows (stator indexing) is an aspect of multistage compressor design that has not yet been explored for its potential impact on compressor aerodynamic performance. Although the inlet stages of multistage compressors usually have differing stator blade counts, the aft stages of core compressors can often have stage blocks with equal stator blade counts in successive stages. The potential impact of stator indexing is likely greatest in these stages. To assess the performance impact of stator indexing, researchers at the NASA Lewis Research Center used the 4 ft diameter, four-stage NASA Low Speed Axial Compressor for detailed experiments. This compressor has geometrically identical stages that can circumferentially index stator rows relative to each other in a controlled manner; thus it is an ideal test rig for such investigations.

Research and development of energy-efficient high back-pressure compressor

NASA Astrophysics Data System (ADS)

1983-09-01

Improved-efficiency compressors were developed in four capacity sizes. Changes to the baseline compressor were made to the motors, valve plates, and mufflers. The adoption of a slower running speed compressor required larger displacements to maintain the desired capacity. This involved both bore and stroke modifications. All changes that were made to the compressor are readily adaptable to manufacture. Prototype compressors were built and tested. The largest capacity size (4000 Btu/h) was selected for testing in a vending machine. Additional testing was performed on the prototype compressors in order to rate them on an alternate refrigerant. A market analysis was performed to determine the potential acceptance of the improved-efficiency machines by a vending machine manufacturer, who supplies a retail sales system of a major soft drink company.

Recirculating rotary gas compressor

DOEpatents

Weinbrecht, John F.

1992-01-01

A positive displacement, recirculating Roots-type rotary gas compressor which operates on the basis of flow work compression. The compressor includes a pair of large diameter recirculation conduits (24 and 26) which return compressed discharge gas to the compressor housing (14), where it is mixed with low pressure inlet gas, thereby minimizing adiabatic heating of the gas. The compressor includes a pair of involutely lobed impellers (10 and 12) and an associated port configuration which together result in uninterrupted flow of recirculation gas. The large diameter recirculation conduits equalize gas flow velocities within the compressor and minimize gas flow losses. The compressor is particularly suited to applications requiring sustained operation at higher gas compression ratios than have previously been feasible with rotary pumps, and is particularly applicable to refrigeration or other applications requiring condensation of a vapor.

New concept single screw compressors and their manufacture technology

NASA Astrophysics Data System (ADS)

Feng, Q.; Liu, F.; Chang, L.; Feng, C.; Peng, C.; Xie, J.; van den Broek, M.

2017-08-01

Single screw compressors were generally acknowledged as one of the nearly perfect machines by compressor researchers and manufacturers. However the rapid wear of the star-wheel in a single screw compressor during operation is a key reason why it hasn’t previously joined the main current compressors’ market. After more than ten years of effective work, the authors of this paper have proposed a new concept single screw compressor whose mesh-couple profile is enveloped with multi-column. Also a new design method and manufacture equipment for this kind of compressor have been developed and are described in this paper. A lot of prototype tests and a long period of industrial operations under full loading conditions have shown that the mesh-couple profiles of the new concept single compressors have excellent anti-wearness.

Recirculating rotary gas compressor

DOEpatents

Weinbrecht, J.F.

1992-02-25

A positive displacement, recirculating Roots-type rotary gas compressor is described which operates on the basis of flow work compression. The compressor includes a pair of large diameter recirculation conduits which return compressed discharge gas to the compressor housing, where it is mixed with low pressure inlet gas, thereby minimizing adiabatic heating of the gas. The compressor includes a pair of involutely lobed impellers and an associated port configuration which together result in uninterrupted flow of recirculation gas. The large diameter recirculation conduits equalize gas flow velocities within the compressor and minimize gas flow losses. The compressor is particularly suited to applications requiring sustained operation at higher gas compression ratios than have previously been feasible with rotary pumps, and is particularly applicable to refrigeration or other applications requiring condensation of a vapor. 12 figs.

Centrifugal Compressor Surge Controlled

NASA Technical Reports Server (NTRS)

Skoch, Gary J.

2003-01-01

It shows the variation in compressor mass flow with time as the mass flow is throttled to drive the compressor into surge. Surge begins where wide variations in mass flow occur. Air injection is then turned on to bring about a recovery from the initial surge condition and stabilize the compressor. The throttle is closed further until surge is again initiated. Air injection is increased to again recover from the surge condition and stabilize the compressor.

Thorough clinical evaluation of skin, as well as oral, genital and anal mucosa is beneficial in lichen planus patients.

PubMed

Stojanovic, Larisa; Lunder, Tomaz; Rener-Sitar, Ksenija; Mlakar, Bostjan; Maticic, Mojca

2011-03-01

Lichen planus (LP) is a common mucocutaneous disease of unknown aetiology with various geographical prevalence, may be related to some serious disorders such as squamous cell carcinoma and often remains underdiagnosed. The aim of this retrospective study was to thoroughly determine localization and clinical characteristics of LP lesions in a cohort of 173 Slovenian patients in association to the presence of accompanying symptoms and history of potential stressful events. Isolated cutaneous lesions of LP were found in 56.6% and isolated oral LP in 3.5% of patients. Thirty-four percent presented orocutaneous LP, whereas genitocutaneous LP was noted in 1.2%, orogenito-cutaneous LP in 4% and orogenital LP in 0.5% of patients. Underlying stressful events were noted in 36 out of 137 (26.3%) patients. Despite obviously visible localization of the lesions various medical specialists should be familiar with LP and thoroughly examine the complete skin, as well as oral, genital and anal mucosa in each LP patient to avoid a delay in diagnosing this disease and possibly disclose a much serious underlying condition. Psychological support should be offered, if needed.

Updated Status and Performance at the Fourth HST COS FUV Lifetime Position

NASA Astrophysics Data System (ADS)

Taylor, Joanna M.; De Rosa, Gisella; Fix, Mees B.; Fox, Andrew; Indriolo, Nick; James, Bethan; Jedrzejewski, Robert I.; Oliveira, Cristina M.; Penton, Steven V.; Plesha, Rachel; Proffitt, Charles R.; Rafelski, Marc; Roman-Duval, Julia; Sahnow, David J.; Snyder, Elaine M.; Sonnentrucker, Paule; White, James

2017-06-01

To mitigate the adverse effects of gain sag on the spectral quality and accuracy of Hubble Space Telescope’s Cosmic Origins Spectrograph FUV observations, COS FUV spectra will be moved from Lifetime Position 3 (LP3) to a new pristine location on the detectors at LP4 in July 2017. To achieve maximal spectral resolution while preserving detector area, the spectra will be shifted in the cross-dispersion (XD) direction by -2.5" (about -31 pixels) from LP3 or -5” (about 62 pixels) from the original LP1. At LP4, the wavelength calibration lamp spectrum can overlap with the previously gain-sagged LP2 PSA spectrum location. If lamp lines fall in the gain sag holes from LP2, it can cause line ratios to change and the wavelength calibration to fail. As a result, we have updated the Wavecal Parameters Reference Table and CalCOS to address this issue. Additionally, it was necessary to extend the current geometric correction in order to encompass the entire LP4 location. Here we present 2-D template profiles and 1-D spectral trace centroids derived at LP4 as well as LP4-related updates to the wavelength calibration, and geometric correction.

Men exhibit greater fatigue resistance than women in alternated bench press and leg press exercises.

PubMed

Monteiro, Estêvão R; Steele, James; Novaes, Jefferson S; Brown, Amanda F; Cavanaugh, Mark T; Vingren, Jakob L; Behm, David G

2017-11-17

The purpose of this study was to evaluate the influence of sex, exercise order, and rest interval on neuromuscular fatigue resistance for an alternated strength training sequence of bench press (BP) and leg press (LP) exercises. Twelve women and 16 men, both recreationally trained, performed four sessions in a random order: 1) BP followed by LP with three-minutes rest (BP+LP with rest), 2) LP followed by BP with three-minutes rest (LP+BP with rest), 3) BP followed by LP without rest interval (BP+LP no rest), and 4) LP followed by BP without rest interval (LP+BP no rest). Participants performed four sets with 100% of 10RM load to concentric failure with the goal of completing the maximum number of repetitions in both exercises. The fatigue index was analyzed from the first and last sets of each exercise bout. A main effect for sex showed that women exhibited 25.5% (p=0.001) and 24.5% (p=0.001) greater BP and LP fatigue than men respectively when performing 10RM. Men exhibited greater BP (p<0.0001; 34.1%) and LP (p<0.0001; 30.5%) fatigue resistance when a rest period was provided. Men did not show an exercise order effect for BP fatigue and exhibited greater (p=0.0003; 14.5%) LP fatigue resistance when BP was performed first. The present study demonstrated the greater fatigue resistance of men when performing 10RM BP and LP exercises. Since men tend to experience less fatigue with the second exercise in the exercise pairing, women's training programs should be adjusted to ensure they do not parallel men's resistance training programs.

Ice-binding proteins confer freezing tolerance in transgenic Arabidopsis thaliana.

PubMed

Bredow, Melissa; Vanderbeld, Barbara; Walker, Virginia K

2017-01-01

Lolium perenne is a freeze-tolerant perennial ryegrass capable of withstanding temperatures below -13 °C. Ice-binding proteins (IBPs) presumably help prevent damage associated with freezing by restricting the growth of ice crystals in the apoplast. We have investigated the expression, localization and in planta freezing protection capabilities of two L. perenne IBP isoforms, LpIRI2 and LpIRI3, as well as a processed IBP (LpAFP). One of these isoforms, LpIRI2, lacks a conventional signal peptide and was assumed to be a pseudogene. Nevertheless, both LpIRI2 and LpIRI3 transcripts were up-regulated following cold acclimation. LpIRI2 also demonstrated ice-binding activity when produced recombinantly in Escherichia coli. Both the LpIRI3 and LpIRI2 isoforms appeared to accumulate in the apoplast of transgenic Arabidopsis thaliana plants. In contrast, the fully processed isoform, LpAFP, remained intracellular. Transgenic plants expressing either LpIRI2 or LpIRI3 showed reduced ion leakage (12%-39%) after low-temperature treatments, and significantly improved freezing survival, while transgenic LpAFP-expressing lines did not confer substantial subzero protection. Freeze protection was further enhanced by with the introduction of more than one IBP isoform; ion leakage was reduced 26%-35% and 10% of plants survived temperatures as low as -8 °C. Our results demonstrate that apoplastic expression of multiple L. perenne IBP isoforms shows promise for providing protection to crops susceptible to freeze-induced damage. © 2016 The Authors. Plant Biotechnology Journal published by Society for Experimental Biology and The Association of Applied Biologists and John Wiley & Sons Ltd.

Three-Dimensional Aerodynamic Instabilities In Multi-Stage Axial Compressors

NASA Technical Reports Server (NTRS)

Tan, Choon S.; Gong, Yifang; Suder, Kenneth L. (Technical Monitor)

2001-01-01

This thesis presents the conceptualization and development of a computational model for describing three-dimensional non-linear disturbances associated with instability and inlet distortion in multistage compressors. Specifically, the model is aimed at simulating the non-linear aspects of short wavelength stall inception, part span stall cells, and compressor response to three-dimensional inlet distortions. The computed results demonstrated the first-of-a-kind capability for simulating short wavelength stall inception in multistage compressors. The adequacy of the model is demonstrated by its application to reproduce the following phenomena: (1) response of a compressor to a square-wave total pressure inlet distortion; (2) behavior of long wavelength small amplitude disturbances in compressors; (3) short wavelength stall inception in a multistage compressor and the occurrence of rotating stall inception on the negatively sloped portion of the compressor characteristic; (4) progressive stalling behavior in the first stage in a mismatched multistage compressor; (5) change of stall inception type (from modal to spike and vice versa) due to IGV stagger angle variation, and "unique rotor tip incidence" at these points where the compressor stalls through short wavelength disturbances. The model has been applied to determine the parametric dependence of instability inception behavior in terms of amplitude and spatial distribution of initial disturbance, and intra-blade-row gaps. It is found that reducing the inter-blade row gaps suppresses the growth of short wavelength disturbances. It is also concluded from these parametric investigations that each local component group (rotor and its two adjacent stators) has its own instability point (i.e. conditions at which disturbances are sustained) for short wavelength disturbances, with the instability point for the compressor set by the most unstable component group. For completeness, the methodology has been extended to describe finite amplitude disturbances in high-speed compressors. Results are presented for the response of a transonic compressor subjected to inlet distortions.

49 CFR 192.167 - Compressor stations: Emergency shutdown.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Components § 192.167 Compressor stations: Emergency shutdown. (a) Except for unattended field compressor... fires, and electrical facilities in the vicinity of gas headers and in the compressor building, except that: (i) Electrical circuits that supply emergency lighting required to assist station personnel in...

49 CFR 192.167 - Compressor stations: Emergency shutdown.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Components § 192.167 Compressor stations: Emergency shutdown. (a) Except for unattended field compressor... fires, and electrical facilities in the vicinity of gas headers and in the compressor building, except that: (i) Electrical circuits that supply emergency lighting required to assist station personnel in...

Oil flow at the scroll compressor discharge: visualization and CFD simulation

NASA Astrophysics Data System (ADS)

Xu, Jiu; Hrnjak, Pega

2017-08-01

Oil is important to the compressor but has other side effect on the refrigeration system performance. Discharge valves located in the compressor plenum are the gateway for the oil when leaving the compressor and circulate in the system. The space in between: the compressor discharge plenum has the potential to separate the oil mist and reduce the oil circulation ratio (OCR) in the system. In order to provide information for building incorporated separation feature for the oil flow near the compressor discharge, video processing method is used to quantify the oil droplets movement and distribution. Also, CFD discrete phase model gives the numerical approach to study the oil flow inside compressor plenum. Oil droplet size distributions are given by visualization and simulation and the results show a good agreement. The mass balance and spatial distribution are also discussed and compared with experimental results. The verification shows that discrete phase model has the potential to simulate the oil droplet flow inside the compressor.

Technology’s present situation and the development prospects of energy efficiency monitoring as well as performance testing & analysis for process flow compressors

NASA Astrophysics Data System (ADS)

Li, L.; Zhao, Y.; Wang, L.; Yang, Q.; Liu, G.; Tang, B.; Xiao, J.

2017-08-01

In this paper, the background of performance testing of in-service process flow compressors set in user field are introduced, the main technique barriers faced in the field test are summarized, and the factors that result in real efficiencies of most process flow compressors being lower than the guaranteed by manufacturer are analysed. The authors investigated the present operational situation of process flow compressors in China and found that low efficiency operation of flow compressors is because the compressed gas is generally forced to flow back into the inlet pipe for adapting to the process parameters variety. For example, the anti-surge valve is always opened for centrifugal compressor. To improve the operation efficiency of process compressors the energy efficiency monitoring technology was overviewed and some suggestions are proposed in the paper, which is the basis of research on energy efficiency evaluation and/or labelling of process compressors.

Serum lipoprotein(a) concentration as a cardiovascular risk factor in Kuwaiti type 2 diabetic patients.

PubMed

Abdella, N A; Mojiminiyi, O A; Akanji, A O; Al Mohammadi, H; Moussa, M A

2001-01-01

Serum lipoprotein(a) [Lp(a)], a risk factor for coronary heart disease (CHD) in some nondiabetic populations, is largely under genetic control and varies among ethnic and racial groups. We evaluated serum Lp(a) concentration and its relationship with traditional CHD risk factors (age, sex, smoking, hypertension, dyslipidemia) as well as stage of diabetic nephropathy in 345 type 2 diabetic patients. Lp(a) concentration was skewed with median (2.5th, 97.5th percentiles) of 25.0 (8.1, 75.7) mg/dl. Twenty-three of 55 (41.8%) patients with CHD had increased (>30 mg/dl) Lp(a) compared with 102 of 290 (35.1%) patients without CHD (P=.35). Twelve of 27 (44.4%) female patients with CHD had increased Lp(a) compared to 11 of 28 (39.3%) males (P=.70). Lp(a) was significantly (P<.05) higher in females than males, but the logistic regression analysis showed significant association of Lp(a), LDL-C, and duration of diabetes mellitus (DM) with CHD in male patients only. Although female patients with CHD and macroalbuminuria had significantly (P<.05) higher Lp(a) than normoalbuminuric female patients without CHD, no such association was found in males and no significant association was found between Lp(a) and the degree of albuminuria. Partial correlation analysis controlling for age, sex, and BMI showed significant correlation of Lp(a) with total cholesterol only (P=.03) and no correlation was found with other lipid parameters. Multiple regression analysis did not show significant associations of Lp(a) with standard CHD risk factors, HbA(1c), and plasma creatinine. This study is in agreement with studies in other populations, which showed that Lp(a) may not be an independent risk factor for CHD in patients with DM. However, as Lp(a) could promote atherogenesis via several mechanisms, follow-up studies in our patients will confirm if increased Lp(a) concentration can partly account for the poorer prognosis when diabetic patients develop CHD.

Transcriptomic changes of Legionella pneumophila in water.

PubMed

Li, Laam; Mendis, Nilmini; Trigui, Hana; Faucher, Sébastien P

2015-08-26

Legionella pneumophila (Lp) is a water-borne opportunistic pathogen. In water, Lp can survive for an extended period of time until it encounters a permissive host. Therefore, identifying genes that are required for survival in water may help develop strategies to prevent Legionella outbreaks. We compared the global transcriptomic response of Lp grown in a rich medium to that of Lp exposed to an artificial freshwater medium (Fraquil) for 2, 6 and 24 hours. We uncovered successive changes in gene expression required for the successful adaptation to a nutrient-limited water environment. The repression of major pathways involved in cell division, transcription and translation, suggests that Lp enters a quiescent state in water. The induction of flagella associated genes (flg, fli and mot), enhanced-entry genes (enh) and some Icm/Dot effector genes suggests that Lp is primed to invade a suitable host in response to water exposure. Moreover, many genes involved in resistance to antibiotic and oxidative stress were induced, suggesting that Lp may be more tolerant to these stresses in water. Indeed, Lp exposed to water is more resistant to erythromycin, gentamycin and kanamycin than Lp cultured in rich medium. In addition, the bdhA gene, involved in the degradation pathway of the intracellular energy storage compound polyhydroxybutyrate, is also highly expressed in water. Further characterization show that expression of bdhA during short-term water exposure is dependent upon RpoS, which is required for the survival of Lp in water. Deletion of bdhA reduces the survival of Lp in water at 37 °C. The increase of antibiotic resistance and the importance of bdhA to the survival of Lp in water seem consistent with the observed induction of these genes when Lp is exposed to water. Other genes that are highly induced upon exposure to water could also be necessary for Lp to maintain viability in the water environment.

Layout of bunch compressor for Beijing XFEL test facility

NASA Astrophysics Data System (ADS)

Zhu, Xiongwei; Du, Yingchao; He, Xiaozhong; Yang, Yufeng

2006-10-01

In this paper, we describe the layout of the bunch compressor for the Beijing XFEL test facility (BTF). Our bunch compressor setup is different from the usual one due to the space limit. The compensation X-BAND cavity and the first bunch compressor are separate in distance. The electron bunch is decelerated first and then accelerated to enter the first bunch compressor. The simulation result shows that our setup works well, and the nonlinear term is well compensated. Also, we present the result about the CSR emittance dilution study. Finally, we develop a program to study microbunch instability in the second BTF bunch compressor.

Three-wheel air turbocompressor for PEM fuel cell systems

DOEpatents

Rehg, Tim; Gee, Mark; Emerson, Terence P.; Ferrall, Joe; Sokolov, Pavel

2003-08-19

A fuel cell system comprises a compressor and a fuel processor downstream of the compressor. A fuel cell stack is in communication with the fuel processor and compressor. A combustor is downstream of the fuel cell stack. First and second turbines are downstream of the fuel processor and in parallel flow communication with one another. A distribution valve is in communication with the first and second turbines. The first and second turbines are mechanically engaged to the compressor. A bypass valve is intermediate the compressor and the second turbine, with the bypass valve enabling a compressed gas from the compressor to bypass the fuel processor.

Multiple volume compressor for hot gas engine

DOEpatents

Stotts, Robert E.

1986-01-01

A multiple volume compressor for use in a hot gas (Stirling) engine having a plurality of different volume chambers arranged to pump down the engine when decreased power is called for and return the working gas to a storage tank or reservoir. A valve actuated bypass loop is placed over each chamber which can be opened to return gas discharged from the chamber back to the inlet thereto. By selectively actuating the bypass valves, a number of different compressor capacities can be attained without changing compressor speed whereby the capacity of the compressor can be matched to the power available from the engine which is used to drive the compressor.

Performance of J-33-A-21 and J-33-A-23 Compressors with and without Water Injection

NASA Technical Reports Server (NTRS)

Beede, William L.

1948-01-01

In an investigation of the J-33-A-21 and the J-33-A-23 compressors with and without water injection, it was discovered that the compressors reacted differently to water injection although they were physically similar. An analysis of the effect of water injection on compressor performance and the consequent effect on matching of the compressor and turbine components in the turbojet engine was made. The analysis of component matching is based on a turbine flow function defined as the product of the equivalent weight flow and the reciprocal of the compressor pressure ratio.

CF6 Jet Engine Diagnostics Program: High pressure compressor clearance investigation

NASA Technical Reports Server (NTRS)

Radomski, M. A.

1982-01-01

The effects of high pressure compressor clearance changes on engine performance were experimentally determined on a CF6 core engine. The results indicate that a one percent reduction in normalized average clearance, expressed as a fraction of airfoil length, improves compressor efficiency by one percent. Compressor clearances are reduced by the application of rotor bore cooling, insulation of the stator casing, and use of a low coefficient of expansion material in the aft stages. This improvement amounts to a reduction of normalized average clearance of 0.78 percent, relative to CF6-60 compressor, which is equivalent to an improvement in compressor efficiency of 0.78 percent.

Biosynthesis and processing of bovine cartilage link proteins.

PubMed

Hering, T M; Sandell, L J

1990-02-05

We have examined posttranslational modifications which are responsible for converting an apparently single precursor (Hering, T. M., and Sandell, L. J. (1988) J. Biol. Chem. 263, 1030-1036) to the two major forms of link protein in bovine articular cartilage. Resistance to endoglycosidases H and F suggests that Asn-linked oligosaccharides of link protein secreted by bovine chondrocytes in culture are of the complex or hybrid type. There is no evidence for O-linked oligosaccharides. There is no apparent precursor-product relationship between link protein (LP)1 and LP2, since after a short pulse with [3H]leucine two forms are present, consistent with the existence of two glycosylation sites. An immunoprecipitate of LP1 from pulse-labeled chondrocytes was observed to show a decrease in electrophoretic mobility and increased microheterogeneity during transit through the Golgi, whereas LP2 did not change. During processing both LP1 and LP2 become endoglycosidase H resistant. LP1, but not LP2, can be biosynthetically labeled with [35S]sulfate. Incorporation of [35S]sulfate is inhibited by tunicamycin, indicating that the sulfate is associated with Asn-linked carbohydrate. Sulfation may be important for normal processing, secretion, or degradation of link protein and with sialylation may confer considerable charge heterogeneity upon LP1. We conclude that there are considerable biochemical differences between glycoproteins LP1 and LP2 which may provide a basis for functional differences.

Osteoblast adhesion on novel machinable calcium phosphate/lanthanum phosphate composites for orthopedic applications.

PubMed

Ergun, Celaletdin; Liu, Huinan; Webster, Thomas J

2009-06-01

Lanthanum phosphate (LaPO(4), LP) was combined with either hydroxyapatite (HA) or tricalcium phosphate (TCP) to form novel composites for orthopedic applications. In this study, these composites were prepared by wet chemistry synthesis and subsequent powder mixing. These HA/LP and TCP/LP composites were characterized in terms of phase stability and microstructure evolution during sintering using X-ray diffraction (XRD) and scanning electron microscopy (SEM). Their machinability was evaluated using a direct drilling test. For HA/LP composites, LP reacted with HA during sintering and formed a new phase, Ca(8)La(2)(PO(4))(6)O(2), as a reaction by-product. However, TCP/LP composites showed phase stability and the formation of a weak interface between TCP and LP machinability when sintered at 1100 degrees C, which is crucial for achieving desirable properties. Thus, these novel TCP/LP composites fulfilled the requirements for machinability, a key consideration for manufacturing orthopedic implants. Moreover, the biocompatibility of these novel LP composites was studied, for the first time, in this paper. In vitro cell culture tests demonstrated that the LP and its composites supported osteoblast (bone-forming cell) adhesion similar to natural bioceramics (such as HA and TCP). In conclusion, these novel LP composites should be further studied and developed for more effectively treating bone related diseases or injuries. 2008 Wiley Periodicals, Inc.

The Relationship between Lichen Planus and Carotid Intima Media Thickness.

PubMed

C, Koseoglu; M, Erdogan; G, Koseoglu; O, Kurmus; Ag, Ertem; Th, Efe; Gi, Kurmus; T, Durmaz; T, Keles; E, Bozkurt

2016-11-01

Lichen planus (LP) is a chronic inflammatory disease. Although the association between chronic inflammation and subclinical atherosclerosis has been reported in the literature, the relationship between LP and carotid intima media thickness (CIMT) has not been previously investigated. The aim of this study was to investigate the relationship between LP and CIMT. One hundred eleven LP patients and 105 controls were enrolled in the study. Then, CIMT examination was performed with an ultrasonography device. Cross-sectional associations of LP with CIMT were analyzed using linear regression models adjusted for related confounders. No statistical difference was found between LP and the controls except for the female gender, white blood cell, LDL cholesterol and triglycerides (p = 0.046, p = 0.019, p = 0.011 and p = 0.013, respectively). Significant difference was found between the groups in terms of CIMT (0.90 ± 0.2 mm vs. 0.61 ± 0.3 mm, p = 0.001). CIMT was correlated with longevity of the LP, but we did not find LP to be an independent predictor of increased CIMT in logistic regression analysis (r = 0.449, p < 0.001, β = -0.117, p = 0.092; respectively). The results of our study suggested that LP was associated with increased mean CIMT, and furthermore that CIMT was correlated with longevity of LP. However, LP was not an independent predictor of increased CIMT.

The Relationship between Lichen Planus and Carotid Intima Media Thickness

PubMed Central

C, Koseoglu; M, Erdogan; G, Koseoglu; O, Kurmus; AG, Ertem; TH, Efe; GI, Kurmus; T, Durmaz; T, Keles; E, Bozkurt

2016-01-01

Background Lichen planus (LP) is a chronic inflammatory disease. Although the association between chronic inflammation and subclinical atherosclerosis has been reported in the literature, the relationship between LP and carotid intima media thickness (CIMT) has not been previously investigated. The aim of this study was to investigate the relationship between LP and CIMT. Methods One hundred eleven LP patients and 105 controls were enrolled in the study. Then, CIMT examination was performed with an ultrasonography device. Cross-sectional associations of LP with CIMT were analyzed using linear regression models adjusted for related confounders. Results No statistical difference was found between LP and the controls except for the female gender, white blood cell, LDL cholesterol and triglycerides (p = 0.046, p = 0.019, p = 0.011 and p = 0.013, respectively). Significant difference was found between the groups in terms of CIMT (0.90 ± 0.2 mm vs. 0.61 ± 0.3 mm, p = 0.001). CIMT was correlated with longevity of the LP, but we did not find LP to be an independent predictor of increased CIMT in logistic regression analysis (r = 0.449, p < 0.001, β = -0.117, p = 0.092; respectively). Conclusions The results of our study suggested that LP was associated with increased mean CIMT, and furthermore that CIMT was correlated with longevity of LP. However, LP was not an independent predictor of increased CIMT. PMID:27899862

Molecular characterization of an Apolipophorin-III gene from the Chinese oak silkworm, Antheraea pernyi (Lepidoptera: Saturniidae).

PubMed

Liu, Qiu-Ning; Lin, Kun-Zhang; Yang, Lin-Nan; Dai, Li-Shang; Wang, Lei; Sun, Yu; Qian, Cen; Wei, Guo-Qing; Liu, Dong-Ran; Zhu, Bao-Jian; Liu, Chao-Liang

2015-03-01

Apolipophorin-III (ApoLp-III) acts in lipid transport, lipoprotein metabolism, and innate immunity in insects. In this study, an ApoLp-III gene of Antheraea pernyi pupae (Ap-ApoLp-III) was isolated and characterized. The full-length cDNA of Ap-ApoLp-III is 687 bp, including a 5'-untranslated region (UTR) of 40 bp, 3'-UTR of 86 bp and an open reading frame of 561 bp encoding a polypeptide of 186 amino acids that contains an Apolipophorin-III precursor domain (PF07464). The deduced Ap-apoLp-III protein sequence has 68, 59, and 23% identity with its orthologs of Manduca sexta, Bombyx mori, and Aedes aegypti, respectively. Phylogenetic analysis showed that the Ap-apoLp-III was close to that of Bombycoidea. qPCR analysis revealed that Ap-ApoLp-III expressed during the four developmental stages and in integument, fat body, and ovaries. After six types of microorganism infections, expression levels of the Ap-ApoLp-III gene were upregulated significantly at different time points compared with control. RNA interference (RNAi) of Ap-ApoLp-III showed that the expression of Ap-ApoLp-III was significantly downregulated using qPCR after injection of E. coli. We infer that the Ap-ApoLp-III gene acts in the innate immunity of A. pernyi. © 2014 Wiley Periodicals, Inc.

Role of learning potential in cognitive remediation: Construct and predictive validity.

PubMed

Davidson, Charlie A; Johannesen, Jason K; Fiszdon, Joanna M

2016-03-01

The construct, convergent, discriminant, and predictive validity of Learning Potential (LP) was evaluated in a trial of cognitive remediation for adults with schizophrenia-spectrum disorders. LP utilizes a dynamic assessment approach to prospectively estimate an individual's learning capacity if provided the opportunity for specific related learning. LP was assessed in 75 participants at study entry, of whom 41 completed an eight-week cognitive remediation (CR) intervention, and 22 received treatment-as-usual (TAU). LP was assessed in a "test-train-test" verbal learning paradigm. Incremental predictive validity was assessed as the degree to which LP predicted memory skill acquisition above and beyond prediction by static verbal learning ability. Examination of construct validity confirmed that LP scores reflected use of trained semantic clustering strategy. LP scores correlated with executive functioning and education history, but not other demographics or symptom severity. Following the eight-week active phase, TAU evidenced little substantial change in skill acquisition outcomes, which related to static baseline verbal learning ability but not LP. For the CR group, LP significantly predicted skill acquisition in domains of verbal and visuospatial memory, but not auditory working memory. Furthermore, LP predicted skill acquisition incrementally beyond relevant background characteristics, symptoms, and neurocognitive abilities. Results suggest that LP assessment can significantly improve prediction of specific skill acquisition with cognitive training, particularly for the domain assessed, and thereby may prove useful in individualization of treatment. Published by Elsevier B.V.

A Stability Enhancement Method for Centrifugal Compressors using Active Control Casing Treatment System

NASA Astrophysics Data System (ADS)

Zhao, Yuanyang; Xiao, Jun; Li, Liansheng; Yang, Qichao; Liu, Guangbin; Wang, Le

2015-08-01

The centrifugal compressors are widely used in many fields. When the centrifugal compressors operate at the edge of the surge line, the compressor will be unstable. In addition, if the centrifugal compressor runs at this situation long time, the damage will be occurred on compressor. There are some kinds of method to improve and enlarge the range of the centrifugal compressors, such as inlet guide vane, and casing treatment. For casing treatment method, some structures have been researched, such as holed recirculation, basic slot casing treatment and groove casing treatment. All these researches are the passive methods. This paper present a new stability enhancement method based Active Control Casing Treatment (ACCT). All parts of this new method are introduced in detail. The control strategy of the system is mentioned in the paper. As a research sample, a centrifugal compressor having this system is researched using CFD method. The study focuses on the effect of the active control system on the impeller flow. The vortex in impeller is changed by the active control system. And this leads to the suppression of the extension of vortex blockage in impeller and to contribute to the enhancement of the compressor operating range.

LP01 to LP0m mode converters using all-fiber two-stage tapers

NASA Astrophysics Data System (ADS)

Mellah, Hakim; Zhang, Xiupu; Shen, Dongya

2015-11-01

A mode converter between LP01 and LP0m modes is proposed using two stages of tapers. The first stage is formed by an adiabatically tapering a circular fiber to excite the desirable LP0m mode. The second stage is formed by inserting an inner core (tapered from both sides) with a refractive index smaller than the original core. This second stage is used to obtain low insertion loss and high extinction ratio of the desired LP0m mode. Three converters between LP01 and LP0m, m=2, 3, and 4, are designed for C-band, and simulation results show that less than 0.24, 0.54 and 0.7 dB insertion loss and higher than 15, 16, and 17.5 dB extinction ratio over the entire band were obtained for the three converters, respectively.

49 CFR 192.171 - Compressor stations: Additional safety equipment.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 3 2011-10-01 2011-10-01 false Compressor stations: Additional safety equipment... Pipeline Components § 192.171 Compressor stations: Additional safety equipment. (a) Each compressor station must have adequate fire protection facilities. If fire pumps are a part of these facilities, their...

30 CFR 56.13010 - Reciprocating-type air compressors.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Reciprocating-type air compressors. 56.13010... NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Compressed Air and Boilers § 56.13010 Reciprocating-type air compressors. (a) Reciprocating-type air compressors...

30 CFR 56.13010 - Reciprocating-type air compressors.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Reciprocating-type air compressors. 56.13010... NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Compressed Air and Boilers § 56.13010 Reciprocating-type air compressors. (a) Reciprocating-type air compressors...

30 CFR 56.13010 - Reciprocating-type air compressors.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Reciprocating-type air compressors. 56.13010... NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Compressed Air and Boilers § 56.13010 Reciprocating-type air compressors. (a) Reciprocating-type air compressors...

30 CFR 56.13010 - Reciprocating-type air compressors.

Code of Federal Regulations, 2010 CFR

2010-07-01

... NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Compressed Air and Boilers § 56.13010 Reciprocating-type air compressors. (a) Reciprocating-type air compressors... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Reciprocating-type air compressors. 56.13010...

30 CFR 57.13010 - Reciprocating-type air compressors.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Reciprocating-type air compressors. 57.13010... NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-UNDERGROUND METAL AND NONMETAL MINES Compressed Air and Boilers § 57.13010 Reciprocating-type air compressors. (a) Reciprocating-type air compressors...

Performance of Compressor of XJ-41-V Turbojet Engine. 1 - Preliminary Investigation at Equivalent Compressor Speed of 8000 rpm

DTIC Science & Technology

1949-01-01

Aircraft Engine Research Laboratory Cleveland, Ohio Restriction Cancelled ^mmmmmmmm ^Md’^| 5;-;» <^~ k NATIONAL ADVISORY COMMTTErUf0...AEEONAUTICS RESEARCH MEMORANDUM for the Air Materiel Command’, Army Air Forces PERFORMANCE OF COMPRESSOR OF XJ-41-V TURBOJET ENGINE I - PRELIMINARY...of the XJ-41-V turbojet - engine compressor. . .’ The complete compressor was amounted on a collecting chamber having an annular air-flow

Economics of water injected air screw compressor systems

NASA Astrophysics Data System (ADS)

Venu Madhav, K.; Kovačević, A.

2015-08-01

There is a growing need for compressed air free of entrained oil to be used in industry. In many cases it can be supplied by oil flooded screw compressors with multi stage filtration systems, or by oil free screw compressors. However, if water injected screw compressors can be made to operate reliably, they could be more efficient and therefore cheaper to operate. Unfortunately, to date, such machines have proved to be insufficiently reliable and not cost effective. This paper describes an investigation carried out to determine the current limitations of water injected screw compressor systems and how these could be overcome in the 15-315 kW power range and delivery pressures of 6-10 bar. Modern rotor profiles and approach to sealing and cooling allow reasonably inexpensive air end design. The prototype of the water injected screw compressor air system was built and tested for performance and reliability. The water injected compressor system was compared with the oil injected and oil free compressor systems of the equivalent size including the economic analysis based on the lifecycle costs. Based on the obtained results, it was concluded that water injected screw compressor systems could be designed to deliver clean air free of oil contamination with a better user value proposition than the oil injected or oil free screw compressor systems over the considered range of operations.

78 FR 21491 - DeltaPoint Capital IV, L.P., DeltaPoint Capital IV (New York), L.P.; Notice Seeking Exemption...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-10

... SMALL BUSINESS ADMINISTRATION [License No. 02/02-0662, 02/02-0661] DeltaPoint Capital IV, L.P., DeltaPoint Capital IV (New York), L.P.; Notice Seeking Exemption Under Section 312 of the Small Business Investment Act, Conflicts of Interest Notice is hereby given that DeltaPoint Capital IV, L.P. and DeltaPoint...

76 FR 38178 - Change in Bank Control Notices; Acquisitions of Shares of a Bank or Bank Holding Company

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-29

..., New York, New York 10045-0001: 1. Thomas H. Lee (Alternative) Fund VI, L.P., Thomas H. Lee (Alternative) Parallel Fund VI, L.P., Thomas H. Lee (Alternative) Parallel (DT) Fund VI, L.P., THL FBC Equity Investors, L.P., THL Advisors (Alternative) VI, L.P., Thomas H. Lee (Alternative) VI, Ltd., THL Managers VI...

Improving of the working process of axial compressors of gas turbine engines by using an optimization method

NASA Astrophysics Data System (ADS)

Marchukov, E.; Egorov, I.; Popov, G.; Baturin, O.; Goriachkin, E.; Novikova, Y.; Kolmakova, D.

2017-08-01

The article presents one optimization method for improving of the working process of an axial compressor of gas turbine engine. Developed method allows to perform search for the best geometry of compressor blades automatically by using optimization software IOSO and CFD software NUMECA Fine/Turbo. Optimization was performed by changing the form of the middle line in the three sections of each blade and shifts of three sections of the guide vanes in the circumferential and axial directions. The calculation of the compressor parameters was performed for work and stall point of its performance map on each optimization step. Study was carried out for seven-stage high-pressure compressor and three-stage low-pressure compressors. As a result of optimization, improvement of efficiency was achieved for all investigated compressors.

Application of Risk-Based Inspection method for gas compressor station

NASA Astrophysics Data System (ADS)

Zhang, Meng; Liang, Wei; Qiu, Zeyang; Lin, Yang

2017-05-01

According to the complex process and lots of equipment, there are risks in gas compressor station. At present, research on integrity management of gas compressor station is insufficient. In this paper, the basic principle of Risk Based Inspection (RBI) and the RBI methodology are studied; the process of RBI in the gas compressor station is developed. The corrosion loop and logistics loop of the gas compressor station are determined through the study of corrosion mechanism and process of the gas compressor station. The probability of failure is calculated by using the modified coefficient, and the consequence of failure is calculated by the quantitative method. In particular, we addressed the application of a RBI methodology in a gas compressor station. The risk ranking is helpful to find the best preventive plan for inspection in the case study.

LpMab-23-recognizing cancer-type podoplanin is a novel predictor for a poor prognosis of early stage tongue cancer.

PubMed

Miyazaki, Akihiro; Nakai, Hiromi; Sonoda, Tomoko; Hirohashi, Yoshihiko; Kaneko, Mika K; Kato, Yukinari; Sawa, Yoshihiko; Hiratsuka, Hiroyoshi

2018-04-20

We report that the reactivity of a novel monoclonal antibody LpMab-23 for human cancer-type podoplanin (PDPN) is a predictor for a poor prognosis of tongue cancer. The association between LpMab-23-recognizing cancer-type PDPN expression and clinical/pathological features were analyzed on 60 patients with stage I and II tongue cancer treated with transoral resection of the primary tumor. In the mode of invasion, the LpMab-23-dull/negative cases were significantly larger in cases with low-grade malignancies and without late cervical lymph node metastasis, than in cases with high-grade malignancies and the metastasis. In the high-grade malignant cases, LpMab-23-positive cases were significantly larger than LpMab-23-dull/negative cases. The Kaplan-Meier curves of the five-year metastasis-free survival rate (MFS) were significantly lower in the LpMab-23 positive patients than in LpMab-23 dull/negative patients. The LpMab-23-dull/negative cases showed the highest MFS in all of the clinical/pathological features and particularly, the MFS of the LpMab-23 positive cases decreased to less than 60% in the first year. In the Cox proportional hazard regression models a comparison of the numbers of LpMab-23 dull/negative with positive cases showed the highest hazard ratio with statistical significance in all of the clinical/pathological features. LpMab-23 positive cases may be considered to present a useful predictor of poor prognosis for early stage tongue cancer.

Increased systolic blood pressure in rat offspring following a maternal low-protein diet is normalized by maternal dietary choline supplementation.

PubMed

Bai, S Y; Briggs, D I; Vickers, M H

2012-10-01

An adverse prenatal environment may induce long-term metabolic consequences, in particular hypertension and cardiovascular disease. A maternal low-protein (LP) diet is well known to result in increased blood pressure (BP) in offspring. Choline has been shown to have direct BP-reducing effects in humans and animals. It has been suggested that endogenous choline synthesis via phosphatidylcholine is constrained during maternal LP exposure. The present study investigates the effect of choline supplementation to mothers fed a LP diet during pregnancy on systolic BP (SBP) in offspring as measured by tail-cuff plethysmography. Wistar rats were assigned to one of three diets to be fed ad libitum throughout pregnancy: (1) control diet (CONT, 20% protein); (2) an LP diet (9% protein); and (3) LP supplemented with choline (LP + C). Dams were fed the CONT diet throughout lactation and offspring were fed the CONT diet from weaning for the remainder of the trial. At postnatal day 150, SBP and retroperitoneal fat mass was significantly increased in LP offspring compared with CONT animals and was normalized in LP + C offspring. Effects of LP + C reduction in SBP were similar in both males and females. Plasma choline and phosphatidylcholine concentrations were not different across treatment groups, but maternal choline supplementation resulted in a significant reduction in homocysteine concentrations in LP + C offspring compared with LP and CONT animals. The present trial shows for the first time that maternal supplementation with dietary choline during periods of LP exposure can normalize increased SBP and fat mass observed in offspring in later life.

ChLpMab-23: Cancer-Specific Human-Mouse Chimeric Anti-Podoplanin Antibody Exhibits Antitumor Activity via Antibody-Dependent Cellular Cytotoxicity.

PubMed

Kaneko, Mika K; Nakamura, Takuro; Kunita, Akiko; Fukayama, Masashi; Abe, Shinji; Nishioka, Yasuhiko; Yamada, Shinji; Yanaka, Miyuki; Saidoh, Noriko; Yoshida, Kanae; Fujii, Yuki; Ogasawara, Satoshi; Kato, Yukinari

2017-06-01

Podoplanin is expressed in many cancers, including oral cancers and brain tumors. The interaction between podoplanin and its receptor C-type lectin-like receptor 2 (CLEC-2) has been reported to be involved in cancer metastasis and tumor malignancy. We previously established many monoclonal antibodies (mAbs) against human podoplanin using the cancer-specific mAb (CasMab) technology. LpMab-23 (IgG 1 , kappa), one of the mouse anti-podoplanin mAbs, was shown to be a CasMab. However, we have not shown the usefulness of LpMab-23 for antibody therapy against podoplanin-expressing cancers. In this study, we first determined the minimum epitope of LpMab-23 and revealed that Gly54-Leu64 peptide, especially Gly54, Thr55, Ser56, Glu57, Asp58, Arg59, Tyr60, and Leu64 of podoplanin, is a critical epitope of LpMab-23. We further produced human-mouse chimeric LpMab-23 (chLpMab-23) and investigated whether chLpMab-23 exerts antibody-dependent cellular cytotoxicity (ADCC) and antitumor activity. In flow cytometry, chLpMab-23 showed high sensitivity against a podoplanin-expressing glioblastoma cell line, LN319, and an oral cancer cell line, HSC-2. chLpMab-23 also showed ADCC activity against podoplanin-expressing CHO cells (CHO/podoplanin). In xenograft models with HSC-2 and CHO/podoplanin, chLpMab-23 exerts antitumor activity using human natural killer cells, indicating that chLpMab-23 could be useful for antibody therapy against podoplanin-expressing cancers.

78 FR 18331 - East Tennessee Natural Gas, LLC; Notice of Intent To Prepare an Environmental Assessment for the...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-26

... Glade Spring Compressor Station and Fordtown Compressor Station. The Kingsport Expansion Project would...; and modifications at the Fordtown Compressor Station. Washington County, Virginia construction of... increase capacity. modifications at the Glade Spring Compressor Station. Washington and Smyth Counties...

77 FR 71585 - Eastern Shore Natural Gas Company; Notice of Intent To Prepare an Environmental Assessment for...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-03

... Compressor Station Upgrade Project and Request for Comments on Environmental Issues The staff of the Federal... discuss the environmental impacts of the Daleville Compressor Station Upgrade Project (Project) involving... compressor engines at its existing Daleville Compressor Station in Chester County, Pennsylvania. One...

78 FR 42062 - Columbia Gas Transmission, LLC; Notice of Intent to Prepare an Environmental Assessment and...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-15

... facilities: New compressor station (Redd Farm Compressor Station) on Columbia's existing Line 1570 in... setting; Modifications to the Smithfield Compressor Station consisting of upgrades to the existing... coolers; Modifications to the Glenville Compressor Station by installing two gas-fired turbines, each...

21 CFR 868.6250 - Portable air compressor.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Portable air compressor. 868.6250 Section 868.6250...) MEDICAL DEVICES ANESTHESIOLOGY DEVICES Miscellaneous § 868.6250 Portable air compressor. (a) Identification. A portable air compressor is a device intended to provide compressed air for medical purposes, e...

30 CFR 56.13012 - Compressor air intakes.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Compressor air intakes. 56.13012 Section 56... MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Compressed Air and Boilers § 56.13012 Compressor air intakes. Compressor air intakes shall be installed to ensure that only...

30 CFR 57.13012 - Compressor air intakes.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Compressor air intakes. 57.13012 Section 57... MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-UNDERGROUND METAL AND NONMETAL MINES Compressed Air and Boilers § 57.13012 Compressor air intakes. Compressor air intakes shall be installed to ensure...

30 CFR 56.13012 - Compressor air intakes.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Compressor air intakes. 56.13012 Section 56... MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Compressed Air and Boilers § 56.13012 Compressor air intakes. Compressor air intakes shall be installed to ensure that only...

30 CFR 57.13012 - Compressor air intakes.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Compressor air intakes. 57.13012 Section 57... MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-UNDERGROUND METAL AND NONMETAL MINES Compressed Air and Boilers § 57.13012 Compressor air intakes. Compressor air intakes shall be installed to ensure...

30 CFR 56.13012 - Compressor air intakes.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Compressor air intakes. 56.13012 Section 56... MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Compressed Air and Boilers § 56.13012 Compressor air intakes. Compressor air intakes shall be installed to ensure that only...

ENVIRONMENTAL TECHNOLOGY VERIFICATION REPORT, FRANCE COMPRESSOR PRODUCTS EMISSIONS PACKING, PHASE I REPORT

EPA Science Inventory

The report presents results of a Phase I test of emissions packing technology offered by France Compressor Products which is designed to reduce methane leaks from compressor rod packing when a compressor is in a standby and pressurized state. This Phase I test was executed betwee...

30 CFR 56.13012 - Compressor air intakes.

Code of Federal Regulations, 2010 CFR

2010-07-01

... MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Compressed Air and Boilers § 56.13012 Compressor air intakes. Compressor air intakes shall be installed to ensure that only... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Compressor air intakes. 56.13012 Section 56...

30 CFR 57.13012 - Compressor air intakes.

Code of Federal Regulations, 2010 CFR

2010-07-01

... MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-UNDERGROUND METAL AND NONMETAL MINES Compressed Air and Boilers § 57.13012 Compressor air intakes. Compressor air intakes shall be installed to ensure... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Compressor air intakes. 57.13012 Section 57...

Compressor Modeling for Engine Control and Maintenance

DTIC Science & Technology

2011-07-01

four compressor stages, while the high pressure compressor (HPC) consists of a set of variable pitch inlet guide vanes ( IGVs ) and 12 compressor...bleed valves at stages 5, 14 and 17, along with the variable IGVs and stators within the engine, are used to relieve the pressure and prevent

21 CFR 868.6250 - Portable air compressor.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Portable air compressor. 868.6250 Section 868.6250...) MEDICAL DEVICES ANESTHESIOLOGY DEVICES Miscellaneous § 868.6250 Portable air compressor. (a) Identification. A portable air compressor is a device intended to provide compressed air for medical purposes, e...

21 CFR 868.6250 - Portable air compressor.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Portable air compressor. 868.6250 Section 868.6250...) MEDICAL DEVICES ANESTHESIOLOGY DEVICES Miscellaneous § 868.6250 Portable air compressor. (a) Identification. A portable air compressor is a device intended to provide compressed air for medical purposes, e...

Miniature Centrifugal Compressor

NASA Technical Reports Server (NTRS)

Sixsmith, Herbert

1989-01-01

Miniature turbocompressor designed for reliability and long life. Cryogenic system includes compressor, turboexpander, and heat exchanger provides 5 W of refrigeration at 70 K from 150 W input power. Design speed of machine 510,000 rpm. Compressor has gas-lubricated journal bearings and magnetic thrust bearing. When compressor runs no bearing contact and no wear.

40 CFR 86.1868-12 - CO2 credits for improving the efficiency of air conditioning systems.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Creditvalue (g/mi) Reduced reheat, with externally-controlled, variable-displacement compressor (e.g. a compressor that controls displacement based on temperature setpoint and/or cooling demand of the air...-controlled, fixed-displacement or pneumatic variable displacement compressor (e.g. a compressor that controls...

49 CFR 192.163 - Compressor stations: Design and construction.

Code of Federal Regulations, 2010 CFR

2010-10-01

... SAFETY TRANSPORTATION OF NATURAL AND OTHER GAS BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Design of... building. Except for a compressor building on a platform located offshore or in inland navigable waters, each main compressor building of a compressor station must be located on property under the control of...

Chaotic Time Series Analysis Method Developed for Stall Precursor Identification in High-Speed Compressors

NASA Technical Reports Server (NTRS)

1997-01-01

A new technique for rotating stall precursor identification in high-speed compressors has been developed at the NASA Lewis Research Center. This pseudo correlation integral method uses a mathematical algorithm based on chaos theory to identify nonlinear dynamic changes in the compressor. Through a study of four various configurations of a high-speed compressor stage, a multistage compressor rig, and an axi-centrifugal engine test, this algorithm, using only a single pressure sensor, has consistently predicted the onset of rotating stall.

77 FR 73637 - Alliance Pipeline L.P.; Notice of Application

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-11

... Pipeline L.P.; Notice of Application Take notice that on November 26, 2012, Alliance Pipeline L.P..., Manager, Regulatory Affairs, Alliance Pipeline Ltd. on behalf of Alliance Pipeline L.P., 800, 605-5 Ave...] BILLING CODE 6717-01-P ...

78 FR 45592 - DeltaPoint Capital IV, LP;

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-29

... Regulations (13 CFR 107.730). DeltaPoint Capital IV, L.P. provided financing to BioMaxx, Inc., 1 Fishers Road... York), L.P., an Associate of DeltaPoint Capital IV, L.P., owns more than ten percent of BioMaxx, Inc...

The Lp_3561 and Lp_3562 Enzymes Support a Functional Divergence Process in the Lipase/Esterase Toolkit from Lactobacillus plantarum

PubMed Central

Esteban-Torres, María; Reverón, Inés; Santamaría, Laura; Mancheño, José M.; de las Rivas, Blanca; Muñoz, Rosario

2016-01-01

Lactobacillus plantarum species is a good source of esterases since both lipolytic and esterase activities have been described for strains of this species. No fundamental biochemical difference exists among esterases and lipases since both share a common catalytic mechanism. L. plantarum WCFS1 possesses a protein, Lp_3561, which is 44% identical to a previously described lipase, Lp_3562. In contrast to Lp_3562, Lp_3561 was unable to degrade esters possessing a chain length higher than C4 and the triglyceride tributyrin. As in other L. plantarum esterases, the electrostatic potential surface around the active site in Lp_3561 is predicted to be basic, whereas it is essentially neutral in the Lp_3562 lipase. The fact that the genes encoding both proteins were located contiguously in the L. plantarum WCFS1 genome, suggests that they originated by tandem duplication, and therefore are paralogs as new functions have arisen during evolution. The presence of the contiguous lp_3561 and lp_3562 genes was studied among L. plantarum strains. They are located in a 8,903 bp DNA fragment that encodes proteins involved in the catabolism of sialic acid and are predicted to increase bacterial adaptability under certain growth conditions. PMID:27486450

Numerical Prediction of the Influence of Thrust Reverser on Aeroengine's Aerodynamic Stability

NASA Astrophysics Data System (ADS)

Zhiqiang, Wang; Xigang, Shen; Jun, Hu; Xiang, Gao; Liping, Liu

2017-11-01

A numerical method was developed to predict the aerodynamic stability of a high bypass ratio turbofan engine, at the landing stage of a large transport aircraft, when the thrust reverser was deployed. 3D CFD simulation and 2D aeroengine aerodynamic stability analysis code were performed in this work, the former is to achieve distortion coefficient for the analysis of engine stability. The 3D CFD simulation was divided into two steps, the single engine calculation and the integrated aircraft and engine calculation. Results of the CFD simulation show that with the decreasing of relative wind Mach number, the engine inlet will suffer more severe flow distortion. The total pressure and total temperature distortion coefficients at the inlet of the engines were obtained from the results of the numerical simulation. Then an aeroengine aerodynamic stability analysis program was used to quantitatively analyze the aerodynamic stability of the high bypass ratio turbofan engine. The results of the stability analysis show that the engine can work stably, when the reverser flow is re-ingested. But the anti-distortion ability of the booster is weaker than that of the fan and high pressure compressor. It is a weak link of engine stability.

Analyses of the Integration of Carbon Dioxide Removal Assembly, Compressor, Accumulator and Sabatier Carbon Dioxide Reduction Assembly

NASA Technical Reports Server (NTRS)

Jeng, Frank F.; Lafuse, Sharon; Smith, Frederick D.; Lu, Sao-Dung; Knox, James C.; Campbell, Mellssa L.; Scull, Timothy D.; Green Steve

2010-01-01

A tool has been developed by the Sabatier Team for analyzing/optimizing CO2 removal assembly, CO2 compressor size, its operation logic, water generation from Sabatier, utilization of CO2 from crew metabolic output, and Hz from oxygen generation assembly. Tests had been conducted using CDRA/Simulation compressor set-up at MSFC in 2003. Analysis of test data has validated CO2 desorption rate profile, CO2 compressor performance, CO2 recovery and CO2 vacuum vent in CDRA desorption. Optimizing the compressor size and compressor operation logic for an integrated closed air revitalization system Is being conducted by the Sabatier Team.

Thermal modelling of a dry revolving vane compressor

NASA Astrophysics Data System (ADS)

Ooi, K. T.; Aw, K. T.

2017-08-01

The lubricant used in compressors serves to lubricate, to seal the gaps to reduce internal leakage and to a certain extent, to cool. However, a lubricant free compressor is attractive if lubricants become a source of contaminant, or in areas where the compressor needs be placed under any orientation, such as those in military or portable computing. In this paper, a thermal model for a dry revolving vane compressor is presented. This thermal model sets out to predict the steady-state operating temperatures of the compressor components. The lumped thermal conductance method was employed. The results of the components temperature will be presented and discussed. A high potential for overheating is observed at the shaft bearings.

Practical experience with unstable compressors

NASA Technical Reports Server (NTRS)

Malanoski, S. B.

1980-01-01

Using analytical mathematical modeling techniques for the system components, an attempt is made to gauge the destabilizing effects in a number of compressor designs. In particular the overhung (or cantilevered) compressor designs and the straddle-mounted (or simply supported) compressor designs are examined. Recommendations are made, based on experiences with stable and unstable compressors, which can be used as guides in future designs. High and low pressure compressors which operate well above their fundamental rotor-bearing lateral natural frequencies can suffer from destructive subsynchronous vibration. Usually the elements in the system design which contribute to this vibration, other than the shafting and the bearings, are the seals (both gas labyrinth and oil breakdown bushings) and the aerodynamic components.

Three Drought-Responsive Members of the Nonspecific Lipid-Transfer Protein Gene Family in Lycopersicon pennellii Show Different Developmental Patterns of Expression1

PubMed Central

Treviño, Marcela B.; Connell, Mary A. O'

1998-01-01

Genomic clones of two nonspecific lipid-transfer protein genes from a drought-tolerant wild species of tomato (Lycopersicon pennellii Corr.) were isolated using as a probe a drought- and abscisic acid (ABA)-induced cDNA clone (pLE16) from cultivated tomato (Lycopersicon esculentum Mill.). Both genes (LpLtp1 and LpLtp2) were sequenced and their corresponding mRNAs were characterized; they are both interrupted by a single intron at identical positions and predict basic proteins of 114 amino acid residues. Genomic Southern data indicated that these genes are members of a small gene family in Lycopersicon spp. The 3′-untranslated regions from LpLtp1 and LpLtp2, as well as a polymerase chain reaction-amplified 3′-untranslated region from pLE16 (cross-hybridizing to a third gene in L. pennellii, namely LpLtp3), were used as gene-specific probes to describe expression in L. pennellii through northern-blot analyses. All LpLtp genes were exclusively expressed in the aerial tissues of the plant and all were drought and ABA inducible. Each gene had a different pattern of expression in fruit, and LpLtp1 and LpLtp2, unlike LpLtp3, were both primarily developmentally regulated in leaf tissue. Putative ABA-responsive elements were found in the proximal promoter regions of LpLtp1 and LpLtp2. PMID:9536064

Ethnicity and lipoprotein(a) polymorphism in Native Mexican populations.

PubMed

Cardoso-Saldaña, G; De La Peña-Díaz, A; Zamora-González, J; Gomez-Ortega, R; Posadas-Romero, C; Izaguirre-Avila, R; Malvido-Miranda, E; Morales-Anduaga, M E; Anglés-Cano, E

2006-01-01

Lp(a) is a lipoparticle of unknown function mainly present in primates and humans. It consists of a low-density lipoprotein and apo(a), a polymorphic glycoprotein. Apo(a) shares sequence homology and fibrin binding with plasminogen, inhibiting its fibrinolytic properties. Lp(a) is considered a link between atherosclerosis and thrombosis. Marked inter-ethnic differences in Lp(a) concentration related to the genetic polymorphism of apo(a) have been reported in several populations. The study examined the structural and functional features of Lp(a) in three Native Mexican populations (Mayos, Mazahuas and Mayas) and in Mestizo subjects. We determined the plasma concentration of Lp(a) by immunonephelometry, apo(a) isoforms by Western blot, Lp(a) fibrin binding by immuno-enzymatic assay and short tandem repeat (STR) polymorphic marker genetic analysis by capillary electrophoresis. Mestizos presented the less skewed distribution and the highest median Lp(a) concentration (13.25 mg dL(-1)) relative to Mazahuas (8.2 mg dL(-1)), Mayas (8.25 mg dL(-1)) and Mayos (6.5 mg dL(-1)). Phenotype distribution was different in Mayas and Mazahuas as compared with the Mestizo group. The higher Lp(a) fibrin-binding capacity was found in the Maya population. There was an inverse relationship between the size of apo(a) polymorphs and both Lp(a) levels and Lp(a) fibrin binding. There is evidence of significative differences in Lp(a) plasma concentration and phenotype distribution in the Native Mexican and the Mestizo group.

Modifying glycyrrhetinic acid liposomes with liver-targeting ligand of galactosylated derivative: preparation and evaluations

PubMed Central

Cheng, Yi; Gao, Youheng; Zheng, Pinjing; Li, Chuangnan; Tong, Yidan; Li, Zhao; Luo, Wenhui; Chen, Zhao

2017-01-01

In this study, novel glycyrrhetinic acid (GA) liposomes modified with a liver-targeting galactosylated derivative ligand (Gal) were prepared using a film-dispersion method. To characterize the samples, particle size, zeta potential, drug loading, and encapsulation efficiency were performed. Moreover, plasma and tissues were pre-treated by liquid-liquid extraction and analyzed by high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS). The results showed that the mean residence times (MRTs) and the area under the curve (AUC) of GA liposomes with Gal (Gal-GA-LP), and GA liposomes (GA-LP) were higher than the GA solution (GA-S) in plasma. The tissue (liver) distribution of Gal-GA-LP was significantly different in contrast to GA-LP. The relative intake rate (Re) of Gal-GA-LP and GA-LP in the liver was 4.752 and 2.196, respectively. The peak concentration ratio (Ce) of Gal-GA-LP and GA-LP in the liver was 2.796 and 1.083, respectively. The targeting efficiency (Te) of Gal-GA-LP and GA-LP in the liver was 48.193% and 34.718%, respectively. Taken together, the results indicate that Gal-GA-LP is an ideal complex for liver-targeting, and has great potential application in the clinical treatment of hepatic diseases. Drug loading and releasing experiments also indicated that most liposomes are spherical structures and have good dispersity under physiologic conditions, which could prolong GA release efficiency in vitro. PMID:29254224

Novel enzymatic method for assaying Lp-PLA2 in serum.

PubMed

Yamaura, Saki; Sakasegawa, Shin-Ichi; Koguma, Emisa; Ueda, Shigeru; Kayamori, Yuzo; Sugimori, Daisuke; Karasawa, Ken

2018-06-01

Measurement of lipoprotein-associated phospholipase A 2 (Lp-PLA 2 ) can be used as an adjunct to traditional cardiovascular risk factors for identifying individuals at higher risk of cardiovascular events. This can be performed by quantification of the protein concentration using an ELISA platform or by measuring Lp-PLA 2 activity using platelet-activating factor (PAF) analog as substrate. Here, an enzymatic Lp-PLA 2 activity assay method using 1-O-Hexadecyl-2-acetyl-rac-glycero-3-phosphocholine (rac C 16 PAF) was developed. The newly revealed substrate specificity of lysoplasmalogen-specific phospholipase D (lysophospholipase D (LysoPLD)) was exploited. Lp-PLA 2 hydrolyzes 1-O-Hexadecyl-2-acetyl-sn-glycero-3-phosphocholine (C 16 PAF) to 1-O-Hexadecyl-2-hydroxy-sn-glycero-3-phosphocholine (LysoPAF). LysoPLD acted on LysoPAF, and the hydrolytically released choline was detected by choline oxidase. Regression analysis of Lp-PLA 2 activity measured by the enzymatic Lp-PLA 2 activity assay vs. two chemical Lp-PLA 2 activity assays, i.e. LpPLA 2 FS and PLAC® test, and ELISA, gave the following correlation coefficients: 0.990, 0.893 and 0.785, respectively (n = 30). Advantages of this enzymatic Lp-PLA 2 activity assay compared with chemical Lp-PLA 2 methods include the following; (i) only requires two reagents enabling a simple two-point linear calibration method with one calibrator (ii) no need for inhibitors of esterase-like activity in serum. Copyright © 2018 Elsevier B.V. All rights reserved.

Ethnicity and lipoprotein(a) polymorphism in Native Mexican populations

PubMed Central

Cardoso-Saldaña, Guillermo; De La Peña-Díaz, Aurora; Zamora-González, José; Gomez-Ortega, Rocio; Posadas-Romero, Carlos; Izaguirre-Avila, Raul; Malvido-Miranda, Elsa; Morales-Anduaga, Maria Elena; Angles-Cano, Eduardo

2006-01-01

Background Lp(a) is a lipoparticle of unknown function mainly present in primates and humans. It consists of a low-density lipoprotein and apo(a), a polymorphic glycoprotein. Apo(a) shares sequence homology and fibrin-binding with plasminogen inhibiting its fibrinolytic properties. Lp(a) is considered a link between atherosclerosis and thrombosis. Marked inter-ethnic differences in Lp(a) concentration related to the genetic polymorphism of apo(a), have been reported in several populations. Aim To study the structural and functional features of Lp(a) in three Native Mexican populations (Mayos, Mazahuas and Mayas) and in Mestizo subjects. Methods We determined the plasma concentration of Lp(a) by immunonephelometry, apo(a) isoforms by Western blot, Lp(a) fibrin-binding by immuno-enzymatic assay and STR polymorphic markers genetic analysis by capillary electrophoresis. Results Mestizos presented the less skewed distribution and the highest median Lp(a) concentration (13.25 mg/dL) relative to Mazahuas (8.2 mg/dL), Mayas (8.25 mg/dL) and Mayos (6.5 mg/dL). Phenotype distribution was different in Mayas and Mazahuas as compared to the Mestizo group. The higher Lp(a) fibrin-binding capacity was found in the Maya population. There was an inverse relationship between the size of apo(a) polymorphs and both Lp(a) levels and Lp(a) fibrin binding. Conclusion There is evidence of significative differences in Lp(a) plasma concentration and phenotype distribution in Native Mexican and the Mestizo group. PMID:16684693

Anthocyanins and flavonols are responsible for purple color of Lablab purpureus (L.) sweet pods.

PubMed

Cui, Baolu; Hu, Zongli; Zhang, Yanjie; Hu, Jingtao; Yin, Wencheng; Feng, Ye; Xie, Qiaoli; Chen, Guoping

2016-06-01

Lablab pods, as dietary vegetable, have high nutritional values similar to most of edible legumes. Moreover, our studies confirmed that purple lablab pods contain the natural pigments of anthocyanins and flavonols. Compared to green pods, five kinds of anthocyanins (malvidin, delphinidin and petunidin derivatives) were found in purple pods by HPLC-ESI-MS/MS and the major contents were delphinidin derivatives. Besides, nine kinds of polyphenol derivatives (quercetin, myricetin, kaempferol and apigenin derivatives) were detected by UPLC-ESI-MS/MS and the major components were quercetin and myricetin derivatives. In order to discover their molecular mechanism, expression patterns of biosynthesis and regulatory gens of anthocyanins and flavonols were investigated. Experimental results showed that LpPAL, LpF3H, LpF3'H, LpDFR, LpANS and LpPAP1 expressions were significantly induced in purple pods compared to green ones. Meanwhile, transcripts of LpFLS were more abundant in purple pods than green or yellow ones, suggestind that co-pigments of anthocyanins and flavonols are accumulated in purple pods. Under continuously dark condition, no anthocyanin accumulation was detected in purple pods and transcripts of LpCHS, LpANS, LpFLS and LpPAP1 were remarkably repressed, indicating that anthocyanins and flavonols biosynthesis in purple pods was regulated in light-dependent manner. These results indicate that co-pigments of anthocyanins and flavonols contribute to purple pigmentations of pods. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

Preliminary Results of Altitude-Wind-Tunnel Investigation of X24C-4B Turbojet Engine. IV - Performance of Modified Compressor. Part 4; Performance of Modified Compressor

NASA Technical Reports Server (NTRS)

Thorman, H. Carl; Dupree, David T.

1947-01-01

The performance of the 11-stage axial-flow compressor, modified to improve the compressor-outlet velocity, in a revised X24C-4B turbojet engine is presented and compared with the performance of the compressor in the original engine. Performance data were obtained from an investigation of the revised engine in the MACA Cleveland altitude wind tunnel. Compressor performance data were obtained for engine operation with four exhaust nozzles of different outlet area at simulated altitudes from 15,OOO to 45,000 feet, simulated flight Mach numbers from 0.24 to 1.07, and engine speeds from 4000 to 12,500 rpm. The data cover a range of corrected engine speeds from 4100 to 13,500 rpm, which correspond to compressor Mach numbers from 0.30 to 1.00.

Effect of Rotor- and Stator-Blade Modifications on Surge Performance of an 11-Stage Axial-Flow Compressor. I - Original Production Compressor of XJ40-WE-6 Engine

NASA Technical Reports Server (NTRS)

Finger, Harold B.; Essig, Robert H.; Conrad, E. William

1952-01-01

An investigation to increase the compressor surge-limit pressure ratio of the XJ40-WE-6 turbojet engine at high equivalent speeds was conducted at the NACA Lewis altitude wind tunnel. This report evaluates the compressor modifications which were restricted to (1) twisting rotor blades (in place) to change blade section angles and (2) inserting new stator diaphragms with different blade angles. Such configuration changes could be incorporated quickly and easily in existing engines at overhaul depots. It was found that slight improvements in the compressor surge limit were possible by compressor blade adjustment. However, some of the modifications also reduced the engine air flow and hence penalized the thrust. The use of a mixer assembly at the compressor outlet improved the surge limit with no appreciable thrust penalty.

Development of a turbine-compressor for 10 kW class neon turbo-Brayton refrigerator

NASA Astrophysics Data System (ADS)

Hirai, Hirokazu; Hirokawa, Masaki; Yoshida, Shigeru; Sano, Tomonobu; Ozaki, Shinsuke

2014-01-01

We are developing 10 kW class turbo-Brayton refrigerator whose working fluid is neon gas. Its high pressure value is 1 MPa and its low pressure value is 0.5 MPa. The refrigerator consists of two turbine-compressors and a heat exchanger. The turbine-compressor has a turbo-expander on one side of its shaft and a turbo-compressor on the other side of the shaft. Two turbo-compressors are connected in series and two turbo-expanders are set in parallel. So, all amount of neon gas is compressed by two stages and each half a mount of neon gas is expanded by one stage. Two turbinecompressors are the same machines and development cost and time are minimized. In this stage, we made one prototype turbine-compressor and installed it in a performance test facility. This paper shows details of the turbine-compressor and refrigerator cooling power simulation results.

An evaluation of 1D loss model collections for the off-design performance prediction of automotive turbocharger compressors

NASA Astrophysics Data System (ADS)

Harley, P.; Spence, S.; Early, J.; Filsinger, D.; Dietrich, M.

2013-12-01

Single-zone modelling is used to assess different collections of impeller 1D loss models. Three collections of loss models have been identified in literature, and the background to each of these collections is discussed. Each collection is evaluated using three modern automotive turbocharger style centrifugal compressors; comparisons of performance for each of the collections are made. An empirical data set taken from standard hot gas stand tests for each turbocharger is used as a baseline for comparison. Compressor range is predicted in this study; impeller diffusion ratio is shown to be a useful method of predicting compressor surge in 1D, and choke is predicted using basic compressible flow theory. The compressor designer can use this as a guide to identify the most compatible collection of losses for turbocharger compressor design applications. The analysis indicates the most appropriate collection for the design of automotive turbocharger centrifugal compressors.

Performance characteristics of the Cooper PC-9 centrifugal compressor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Foster, R.E.; Neely, R.F.

1988-06-30

Mathematical performance modeling of the PC-9 centrifugal compressor has been completed. Performance characteristics curves have never been obtained for them in test loops with the same degree of accuracy as for the uprated axial compressors and, consequently, computer modeling of the top cascade and purge cascades has been very difficult and of limited value. This compressor modeling work has been carried out in an attempt to generate data which would more accurately define the compressor's performance and would permit more accurate cascade modeling. A computer code, COMPAL, was used to mathematically model the PC-9 performance with variations in gas composition,more » flow ratios, pressure ratios, speed and temperature. The results of this effort, in the form of graphs, with information about the compressor and the code, are the subject of this report. Compressor characteristic curves are featured. 13 figs.« less

Comprehensive 3D-elastohydrodynamic simulation of hermetic compressor crank drive

NASA Astrophysics Data System (ADS)

Posch, S.; Hopfgartner, J.; Berger, E.; Zuber, B.; Almbauer, R.; Schöllauf, P.

2017-08-01

Mechanical, electrical and thermodynamic losses form the major loss mechanisms of hermetic compressors for refrigeration application. The present work deals with the investigation of the mechanical losses of a hermetic compressor crank drive. Focus is on 3d-elastohydrodynamic (EHD) modelling of the journal bearings, piston-liner contact and piston secondary motion in combination with multi-body and structural dynamics of the crank drive elements. A detailed description of the model development within the commercial software AVL EXCITE Power Unit is given in the work. The model is used to create a comprehensive analysis of the mechanical losses of a hermetic compressor. Further on, a parametric study concerning oil viscosity and compressor speed is carried out which shows the possibilities of the usage of the model in the development process of hermetic compressors for refrigeration application. Additionally, the usage of the results in an overall thermal network for the determination of the thermal compressor behaviour is discussed.

Algorithm for Controlling a Centrifugal Compressor

NASA Technical Reports Server (NTRS)

Benedict, Scott M.

2004-01-01

An algorithm has been developed for controlling a centrifugal compressor that serves as the prime mover in a heatpump system. Experimental studies have shown that the operating conditions for maximum compressor efficiency are close to the boundary beyond which surge occurs. Compressor surge is a destructive condition in which there are instantaneous reversals of flow associated with a high outlet-to-inlet pressure differential. For a given cooling load, the algorithm sets the compressor speed at the lowest possible value while adjusting the inlet guide vane angle and diffuser vane angle to maximize efficiency, subject to an overriding requirement to prevent surge. The onset of surge is detected via the onset of oscillations of the electric current supplied to the compressor motor, associated with surge-induced oscillations of the torque exerted by and on the compressor rotor. The algorithm can be implemented in any of several computer languages.

Study on the CO2 electric driven fixed swash plate type compressor for eco-friendly vehicles

NASA Astrophysics Data System (ADS)

Nam, Donglim; Kim, Kitae; Lee, Jehie; Kwon, Yunki; Lee, Geonho

2017-08-01

The purpose of this study is to experiment and to performance analysis about the electric-driven fixed swash plate compressor using alternate refrigerant(R744). Comprehensive simulation model for an electric driven compressor using CO2 for eco-friendly vehicle is presented. This model consists of compression model and dynamic model. The compression model included valve dynamics, leakage, and heat transfer models. And the dynamic model included frictional loss between piston ring and cylinder wall, frictional loss between shoe and swash plate, frictional loss of bearings, and electric efficiency. Especially, because the efficiency of an electric parts(motor and inverter) in the compressor affects the loss of the compressor, the dynamo test was performed. We made the designed compressor, and tested the performance of the compressor about the variety pressure conditions. Also we compared the performance analysis result and performance test result.

Performance analysis of underwater pump for water-air dual-use engine

NASA Astrophysics Data System (ADS)

Xia, Jun; Wang, Yun; Chen, Yu

2017-10-01

To make water-air dual-use engine work both in air and under water, the compressor of the engine should not only meet the requirements of air flight, but also must have the ability to work underwater. To verify the performance of the compressor when the water-air dual-use engine underwater propulsion mode, the underwater pumping water model of the air compressor is simulated by commercial CFD software, and the flow field analysis is carried out. The results show that conventional air compressors have a certain ability to work in the water environment, however, the blade has a great influence on the flow, and the compressor structure also affects the pump performance. Compressor can initially take into account the two modes of water and air. In order to obtain better performance, the structure of the compressor needs further improvement and optimization.

76 FR 69717 - Natural Gas Pipeline Company of America, LLC; Notice of Intent To Prepare an Environmental...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-09

... proposed Project would consist of the following: Compressor Station 205--Washington County, Iowa Construct and operate a new 3,550 hp gas-fired compressor unit at Natural's Compressor Station 205 located near... Natural's Compressor Station 205. Install new 10-inch-diameter meter. [[Page 69718

75 FR 51455 - Transcontinental Gas Pipe Line Company, LLC; Notice of Intent To Prepare an Environmental...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-20

... loops,\\1\\ construct one new compressor station, add compression at two existing compressor stations, and perform other modifications to five compressor stations. The MSEP would provide about 451 million standard... Mobile Bay Lateral, down to existing Compressor Station 85. According to Transco, its project would...

75 FR 64303 - Tennessee Gas Pipeline Company; Notice of Intent To Prepare an Environmental Assessment for the...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-19

... compressor stations: Compressor Station 319--An inlet gas filter-separator, a blowdown silencer, and a relief valve would be installed and unit piping would be modified at the existing compressor station in Wyalusing Township, Bradford County, Pennsylvania. Compressor Station 321--Approximately 10,310 horsepower...

78 FR 35627 - Columbia Gas Transmission, LLC; Notice of Intent To Prepare an Environmental Assessment for the...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-13

... plans to modify one interconnect in New York, three compressor stations in Pennsylvania and one compressor station in Maryland. The Commission will use this EA in its decision-making process to determine... Compressor Station (Milford, Pennsylvania): Abandon the existing compressors and replace them with two Solar...

46 CFR 197.310 - Air compressor system.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 7 2012-10-01 2012-10-01 false Air compressor system. 197.310 Section 197.310 Shipping... GENERAL PROVISIONS Commercial Diving Operations Equipment § 197.310 Air compressor system. A compressor used to supply breathing air to a diver must have— (a) A volume tank that is— (1) Built and stamped in...

46 CFR 197.310 - Air compressor system.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 7 2013-10-01 2013-10-01 false Air compressor system. 197.310 Section 197.310 Shipping... GENERAL PROVISIONS Commercial Diving Operations Equipment § 197.310 Air compressor system. A compressor used to supply breathing air to a diver must have— (a) A volume tank that is— (1) Built and stamped in...

46 CFR 197.310 - Air compressor system.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 7 2011-10-01 2011-10-01 false Air compressor system. 197.310 Section 197.310 Shipping... GENERAL PROVISIONS Commercial Diving Operations Equipment § 197.310 Air compressor system. A compressor used to supply breathing air to a diver must have— (a) A volume tank that is— (1) Built and stamped in...

46 CFR 197.310 - Air compressor system.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Air compressor system. 197.310 Section 197.310 Shipping... GENERAL PROVISIONS Commercial Diving Operations Equipment § 197.310 Air compressor system. A compressor used to supply breathing air to a diver must have— (a) A volume tank that is— (1) Built and stamped in...

VIEW OF COMPRESSOR ROOM AT GROUND LEVEL SHOWING COMPRESSOR EQUIPMENT. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

VIEW OF COMPRESSOR ROOM AT GROUND LEVEL SHOWING COMPRESSOR EQUIPMENT. VIEW FACING SOUTH - U.S. Naval Base, Pearl Harbor, Ford Island Polaris Missile Lab & U.S. Fleet Ballistic Missile Submarine Training Center, Between Lexington Boulvevard and the sea plane ramps on the southwest side of Ford Island, Pearl City, Honolulu County, HI

75 FR 61461 - Central New York Oil and Gas Company, LLC; Notice of Availability of the Environmental Assessment...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-05

... electric-driven 13,400-horsepower (hp) centrifugal compressor; One new compressor station in Bradford County, Pennsylvania (the NS2 Compressor Station) with an electric-driven 15,300-hp centrifugal... construct, operate, and maintain two new compressor stations in Tioga County, New York and Bradford County...

30 CFR 72.501 - Emission limits for nonpermissible heavy-duty diesel-powered equipment, generators and compressors.

Code of Federal Regulations, 2010 CFR

2010-07-01

... diesel-powered equipment, generators and compressors. 72.501 Section 72.501 Mineral Resources MINE SAFETY... nonpermissible heavy-duty diesel-powered equipment, generators and compressors. (a) Each piece of nonpermissible heavy-duty diesel-powered equipment (as defined by § 75.1908(a) of this part), generator or compressor...

30 CFR 72.501 - Emission limits for nonpermissible heavy-duty diesel-powered equipment, generators and compressors.

Code of Federal Regulations, 2011 CFR

2011-07-01

... diesel-powered equipment, generators and compressors. 72.501 Section 72.501 Mineral Resources MINE SAFETY... nonpermissible heavy-duty diesel-powered equipment, generators and compressors. (a) Each piece of nonpermissible heavy-duty diesel-powered equipment (as defined by § 75.1908(a) of this part), generator or compressor...

Methodology for the determination of criticality codes and recertification intervals for Tank Mounted Air Compressors (TMAC) and Base Mounted Air Compressors (BMAC)

NASA Technical Reports Server (NTRS)

Hargrove, William T.

1991-01-01

This methodology is used to determine inspection procedures and intervals for components contained within tank mounted air compressor systems (TMAC) and base mounted air compressor systems (BMAC). These systems are included in the Pressure Vessel and System Recertification inventory at GSFC.

Centrifugal Compressor Aeroelastic Analysis Code

NASA Astrophysics Data System (ADS)

Keith, Theo G., Jr.; Srivastava, Rakesh

2002-01-01

Centrifugal compressors are very widely used in the turbomachine industry where low mass flow rates are required. Gas turbine engines for tanks, rotorcraft and small jets rely extensively on centrifugal compressors for rugged and compact design. These compressors experience problems related with unsteadiness of flowfields, such as stall flutter, separation at the trailing edge over diffuser guide vanes, tip vortex unsteadiness, etc., leading to rotating stall and surge. Considerable interest exists in small gas turbine engine manufacturers to understand and eventually eliminate the problems related to centrifugal compressors. The geometric complexity of centrifugal compressor blades and the twisting of the blade passages makes the linear methods inapplicable. Advanced computational fluid dynamics (CFD) methods are needed for accurate unsteady aerodynamic and aeroelastic analysis of centrifugal compressors. Most of the current day industrial turbomachines and small aircraft engines are designed with a centrifugal compressor. With such a large customer base and NASA Glenn Research Center being, the lead center for turbomachines, it is important that adequate emphasis be placed on this area as well. Currently, this activity is not supported under any project at NASA Glenn.

Prevention and Mitigation of Acute Radiation Syndrome in Mice by Synthetic Lipopeptide Agonists of Toll-Like Receptor 2 (TLR2)

PubMed Central

Shakhov, Alexander N.; Singh, Vijay K.; Bone, Frederick; Cheney, Alec; Kononov, Yevgeniy; Krasnov, Peter; Bratanova-Toshkova, Troitza K.; Shakhova, Vera V.; Young, Jason; Weil, Michael M.; Panoskaltsis-Mortari, Angela; Orschell, Christie M.; Baker, Patricia S.; Gudkov, Andrei; Feinstein, Elena

2012-01-01

Bacterial lipoproteins (BLP) induce innate immune responses in mammals by activating heterodimeric receptor complexes containing Toll-like receptor 2 (TLR2). TLR2 signaling results in nuclear factor-kappaB (NF-κB)-dependent upregulation of anti-apoptotic factors, anti-oxidants and cytokines, all of which have been implicated in radiation protection. Here we demonstrate that synthetic lipopeptides (sLP) that mimic the structure of naturally occurring mycoplasmal BLP significantly increase mouse survival following lethal total body irradiation (TBI) when administered between 48 hours before and 24 hours after irradiation. The TBI dose ranges against which sLP are effective indicate that sLP primarily impact the hematopoietic (HP) component of acute radiation syndrome. Indeed, sLP treatment accelerated recovery of bone marrow (BM) and spleen cellularity and ameliorated thrombocytopenia of irradiated mice. sLP did not improve survival of irradiated TLR2-knockout mice, confirming that sLP-mediated radioprotection requires TLR2. However, sLP was radioprotective in chimeric mice containing TLR2-null BM on a wild type background, indicating that radioprotection of the HP system by sLP is, at least in part, indirect and initiated in non-BM cells. sLP injection resulted in strong transient induction of multiple cytokines with known roles in hematopoiesis, including granulocyte colony-stimulating factor (G-CSF), keratinocyte chemoattractant (KC) and interleukin-6 (IL-6). sLP-induced cytokines, particularly G-CSF, are likely mediators of the radioprotective/mitigative activity of sLP. This study illustrates the strong potential of LP-based TLR2 agonists for anti-radiation prophylaxis and therapy in defense and medical scenarios. PMID:22479357

Lipoprotein(a) levels predict adverse vascular events after acute myocardial infarction.

PubMed

Mitsuda, Takayuki; Uemura, Yusuke; Ishii, Hideki; Takemoto, Kenji; Uchikawa, Tomohiro; Koyasu, Masayoshi; Ishikawa, Shinji; Miura, Ayako; Imai, Ryo; Iwamiya, Satoshi; Ozaki, Yuta; Kato, Tomohiro; Shibata, Rei; Watarai, Masato; Murohara, Toyoaki

2016-12-01

Lipoprotein(a) [Lp(a)], which is genetically determined, has been reported as an independent risk factor for atherosclerotic vascular disease. However, the prognostic value of Lp(a) for secondary vascular events in patients after coronary artery disease has not been fully elucidated. This 3-year observational study included a total of 176 patients with ST-elevated myocardial infarction (STEMI), whose Lp(a) levels were measured within 24 h after primary percutaneous coronary intervention. We divided enrolled patients into two groups according to Lp(a) level and investigated the association between Lp(a) and the incidence of major adverse cardiac and cerebrovascular events (MACCE). A Kaplan-Meier analysis demonstrated that patients with higher Lp(a) levels had a higher incidence of MACCE than those with lower Lp(a) levels (log-rank P = 0.034). A multivariate Cox regression analysis revealed that Lp(a) levels were independently correlated with the occurrence of MACCE after adjusting for other classical risk factors of atherosclerotic vascular diseases (hazard ratio 1.030, 95 % confidence interval: 1.011-1.048, P = 0.002). In receiver-operating curve analysis, the cutoff value to maximize the predictive power of Lp(a) was 19.0 mg/dl (area under the curve = 0.674, sensitivity 69.2 %, specificity 62.0 %). Evaluation of Lp(a) in addition to the established coronary risk factors improved their predictive value for the occurrence of MACCE. In conclusion, Lp(a) levels at admission independently predict secondary vascular events in patients with STEMI. Lp(a) might provide useful information for the development of secondary prevention strategies in patients with myocardial infarction.

Single-Nucleotide Polymorphisms in LPA Explain Most of the Ancestry-Specific Variation in Lp(a) Levels in African Americans

PubMed Central

Lawson, Kim; Kao, W. H. Linda; Reich, David; Tandon, Arti; Akylbekova, Ermeg; Patterson, Nick; Mosley, Thomas H.; Boerwinkle, Eric; Taylor, Herman A.

2011-01-01

Lipoprotein(a) (Lp(a)) is an important causal cardiovascular risk factor, with serum Lp(a) levels predicting atherosclerotic heart disease and genetic determinants of Lp(a) levels showing association with myocardial infarction. Lp(a) levels vary widely between populations, with African-derived populations having nearly 2-fold higher Lp(a) levels than European Americans. We investigated the genetic basis of this difference in 4464 African Americans from the Jackson Heart Study (JHS) using a panel of up to 1447 ancestry informative markers, allowing us to accurately estimate the African ancestry proportion of each individual at each position in the genome. In an unbiased genome-wide admixture scan for frequency-differentiated genetic determinants of Lp(a) level, we found a convincing peak (LOD = 13.6) at 6q25.3, which spans the LPA locus. Dense fine-mapping of the LPA locus identified a number of strongly associated, common biallelic SNPs, a subset of which can account for up to 7% of the variation in Lp(a) level, as well as >70% of the African-European population differences in Lp(a) level. We replicated the association of the most strongly associated SNP, rs9457951 (p = 6×10−22, 27% change in Lp(a) per allele, ∼5% of Lp(a) variance explained in JHS), in 1,726 African Americans from the Dallas Heart Study and found an even stronger association after adjustment for the kringle(IV) repeat copy number. Despite the strong association with Lp(a) levels, we find no association of any LPA SNP with incident coronary heart disease in 3,225 African Americans from the Atherosclerosis Risk in Communities Study. PMID:21283670

Prevention and mitigation of acute radiation syndrome in mice by synthetic lipopeptide agonists of Toll-like receptor 2 (TLR2).

PubMed

Shakhov, Alexander N; Singh, Vijay K; Bone, Frederick; Cheney, Alec; Kononov, Yevgeniy; Krasnov, Peter; Bratanova-Toshkova, Troitza K; Shakhova, Vera V; Young, Jason; Weil, Michael M; Panoskaltsis-Mortari, Angela; Orschell, Christie M; Baker, Patricia S; Gudkov, Andrei; Feinstein, Elena

2012-01-01

Bacterial lipoproteins (BLP) induce innate immune responses in mammals by activating heterodimeric receptor complexes containing Toll-like receptor 2 (TLR2). TLR2 signaling results in nuclear factor-kappaB (NF-κB)-dependent upregulation of anti-apoptotic factors, anti-oxidants and cytokines, all of which have been implicated in radiation protection. Here we demonstrate that synthetic lipopeptides (sLP) that mimic the structure of naturally occurring mycoplasmal BLP significantly increase mouse survival following lethal total body irradiation (TBI) when administered between 48 hours before and 24 hours after irradiation. The TBI dose ranges against which sLP are effective indicate that sLP primarily impact the hematopoietic (HP) component of acute radiation syndrome. Indeed, sLP treatment accelerated recovery of bone marrow (BM) and spleen cellularity and ameliorated thrombocytopenia of irradiated mice. sLP did not improve survival of irradiated TLR2-knockout mice, confirming that sLP-mediated radioprotection requires TLR2. However, sLP was radioprotective in chimeric mice containing TLR2-null BM on a wild type background, indicating that radioprotection of the HP system by sLP is, at least in part, indirect and initiated in non-BM cells. sLP injection resulted in strong transient induction of multiple cytokines with known roles in hematopoiesis, including granulocyte colony-stimulating factor (G-CSF), keratinocyte chemoattractant (KC) and interleukin-6 (IL-6). sLP-induced cytokines, particularly G-CSF, are likely mediators of the radioprotective/mitigative activity of sLP. This study illustrates the strong potential of LP-based TLR2 agonists for anti-radiation prophylaxis and therapy in defense and medical scenarios.

Isolating and evaluating lactic acid bacteria strains for effectiveness of Leymus chinensis silage fermentation.

PubMed

Zhang, Q; Li, X J; Zhao, M M; Yu, Z

2014-10-01

Five LAB strains were evaluated using the acid production ability test, morphological observation, Gram staining, physiological, biochemical and acid tolerance tests. All five strains (LP1, LP2, LP3, LC1 and LC2) grew at pH 4·0, and LP1 grew at 15°C. Strains LP1, LP2 and LP3 were identified as Lactobacillus plantarum, whereas LC1 and LC2 were classified as Lactobacillus casei by sequencing 16S rDNA. The five isolated strains and two commercial inoculants (PS and CL) were added to native grass and Leymus chinensis (Trin.) Tzvel. for ensiling. All five isolated strains decreased the pH and ammonia nitrogen content, increased the lactic acid content and LP1, LP2 and LP3 increased the acetic content and lactic/acetic acid ratio of L. chinensis silage significantly. The five isolated strains and two commercial inoculants decreased the butyric acid content of the native grass silage. LP2 treatment had lower butyric acid content and ammonia nitrogen content than the other treatments. The five isolated strains improved the quality of L. chinensis silage. The five isolated strains and the two commercial inoculants were not effective in improving the fermentation quality of the native grass silage, but LP2 performed better comparatively. Significance and impact of the study: Leymus chinensis is an important grass in China and Russia, being the primary grass of the short grassland 'steppe' regions of central Asia. However, it has been difficult to make high-quality silage of this species because of low concentration of water-soluble carbohydrates (WSC). Isolating and evaluating lactic acid bacteria strains will be helpful for improving the silage quality of this extensively grown species. © 2014 The Society for Applied Microbiology.

Mipomersen, an antisense oligonucleotide to apolipoprotein B-100, reduces lipoprotein(a) in various populations with hypercholesterolemia: results of 4 phase III trials.

PubMed

Santos, Raul D; Raal, Frederick J; Catapano, Alberico L; Witztum, Joseph L; Steinhagen-Thiessen, Elisabeth; Tsimikas, Sotirios

2015-03-01

Lp(a) is an independent, causal, genetic risk factor for cardiovascular disease and aortic stenosis. Current pharmacological lipid-lowering therapies do not optimally lower Lp(a), particularly in patients with familial hypercholesterolemia (FH). In 4 phase III trials, 382 patients on maximally tolerated lipid-lowering therapy were randomized 2:1 to weekly subcutaneous mipomersen 200 mg (n=256) or placebo (n=126) for 26 weeks. Populations included homozygous FH, heterozygous FH with concomitant coronary artery disease (CAD), severe hypercholesterolemia, and hypercholesterolemia at high risk for CAD. Lp(a) was measured 8× between baseline and week 28 inclusive. Of the 382 patients, 57% and 44% had baseline Lp(a) levels >30 and >50 mg/dL, respectively. In the pooled analysis, the mean percent decrease (median, interquartile range in Lp(a) at 28 weeks was significantly greater in the mipomersen group compared with placebo (-26.4 [-42.8, -5.4] versus -0.0 [-10.7, 15.3]; P<0.001). In the mipomersen group in patients with Lp(a) levels >30 or >50 mg/dL, attainment of Lp(a) values ≤30 or ≤50 mg/dL was most frequent in homozygous FH and severe hypercholesterolemia patients. In the combined groups, modest correlations were present between percent change in apolipoprotein B-100 and Lp(a) (r=0.43; P<0.001) and low-density lipoprotein cholesterol and Lp(a) (r=0.36; P<0.001) plasma levels. Mipomersen consistently and effectively reduced Lp(a) levels in patients with a variety of lipid abnormalities and cardiovascular risk. Modest correlations were present between apolipoprotein B-100 and Lp(a) lowering but the mechanistic relevance mediating Lp(a) reduction is currently unknown. © 2015 American Heart Association, Inc.

Sound reduction of air compressors using a systematic approach

NASA Astrophysics Data System (ADS)

Moylan, Justin Tharp

The noise emitted by portable electric air compressors can often be a nuisance or potentially hazardous to the operator or others nearby. Therefore, reducing the noise of these air compressors is desired. This research focuses on compressors with a reciprocating piston design as this is the most common type of pump design for portable compressors. An experimental setup was developed to measure the sound and vibration of the air compressors, including testing inside a semi-anechoic chamber. The design of a quiet air compressor was performed in four stages: 1) Teardown and benchmarking of air compressors, 2) Identification and isolation of noise sources, 3) Development of individual means to quiet noise sources, 4) Selection and testing of integrated solutions. The systematic approach and results for each of these stages will be discussed. Two redesigned solutions were developed and measured to be approximately 65% quieter than the previous unmodified compressor. An additional analysis was performed on the solutions selected by the participants involved in the selection process. This analysis involved determining which of the design criteria each participant considered most important when selecting solutions. The results from each participant were then compared to their educational background and experience and correlations were identified. The correlations discovered suggest that educational background and experience may be key determinants for the preference models developed.

Available pressure amplitude of linear compressor based on phasor triangle model

NASA Astrophysics Data System (ADS)

Duan, C. X.; Jiang, X.; Zhi, X. Q.; You, X. K.; Qiu, L. M.

2017-12-01

The linear compressor for cryocoolers possess the advantages of long-life operation, high efficiency, low vibration and compact structure. It is significant to study the match mechanisms between the compressor and the cold finger, which determines the working efficiency of the cryocooler. However, the output characteristics of linear compressor are complicated since it is affected by many interacting parameters. The existing matching methods are simplified and mainly focus on the compressor efficiency and output acoustic power, while neglecting the important output parameter of pressure amplitude. In this study, a phasor triangle model basing on analyzing the forces of the piston is proposed. It can be used to predict not only the output acoustic power, the efficiency, but also the pressure amplitude of the linear compressor. Calculated results agree well with the measurement results of the experiment. By this phasor triangle model, the theoretical maximum output pressure amplitude of the linear compressor can be calculated simply based on a known charging pressure and operating frequency. Compared with the mechanical and electrical model of the linear compressor, the new model can provide an intuitionistic understanding on the match mechanism with faster computational process. The model can also explain the experimental phenomenon of the proportional relationship between the output pressure amplitude and the piston displacement in experiments. By further model analysis, such phenomenon is confirmed as an expression of the unmatched design of the compressor. The phasor triangle model may provide an alternative method for the compressor design and matching with the cold finger.

PLC-based mode multi/demultiplexer for MDM transmission

NASA Astrophysics Data System (ADS)

Hanzawa, N.; Saitoh, K.; Sakamoto, T.; Matsui, T.; Tsujikawa, K.; Koshiba, M.; Yamamoto, F.

2013-12-01

We propose a PLC-based multi/demultiplexer (MUX/DEMUX) with a mode conversion function for mode division multiplexing (MDM) transmission applications. The PLC-based mode MUX/DEMUX can realize a low insertion loss and a wide working wavelength bandwidth. We designed and demonstrated a two-mode (LP01 and LP11 modes) and a three-mode (LP01, LP11, and LP21 modes) MUX/DEMUX for use in the C-band.

Design study of the CEPC booster

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, Chuang

2014-12-10

Design study of the CEPC booster is reported. The booster provides 120 GeV beams for the collider with topup injection frequency of 0.1 Hz. To save cost, energy of the linac injector for the booster is chosen as 6GeV, corresponding to the magnetic field of 30 Gs. In this paper, lattice of the booster is described; the low injection energy issues are studied; beam transfer from linac to booster and from booster to collider are discussed.

Method for evaluating the reliability of compressor impeller of turbocharger for vehicle application in plateau area

NASA Astrophysics Data System (ADS)

Wang, Zheng; Wang, Zengquan; Wang, A.-na; Zhuang, Li; Wang, Jinwei

2016-10-01

As turbocharging diesel engines for vehicle application are applied in plateau area, the environmental adaptability of engines has drawn more attention. For the environmental adaptability problem of turbocharging diesel engines for vehicle application, the present studies almost focus on the optimization of performance match between turbocharger and engine, and the reliability problem of turbocharger is almost ignored. The reliability problem of compressor impeller of turbocharger for vehicle application when diesel engines operate in plateau area is studied. Firstly, the rule that the rotational speed of turbocharger changes with the altitude height is presented, and the potential failure modes of compressor impeller are analyzed. Then, the failure behavior models of compressor impeller are built, and the reliability models of compressor impeller operating in plateau area are developed. Finally, the rule that the reliability of compressor impeller changes with the altitude height is studied, the measurements for improving the reliability of the compressor impellers of turbocharger operating in plateau area are given. The results indicate that when the operating speed of diesel engine is certain, the rotational speed of turbocharger increases with the increase of altitude height, and the failure risk of compressor impeller with the failure modes of hub fatigue and blade resonance increases. The reliability of compressor impeller decreases with the increase of altitude height, and it also decreases as the increase of number of the mission profile cycle of engine. The method proposed can not only be used to evaluating the reliability of compressor impeller when diesel engines operate in plateau area but also be applied to direct the structural optimization of compressor impeller.

77 FR 7572 - Alliance Pipeline L.P.; Notice of Application

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-13

...] Alliance Pipeline L.P.; Notice of Application Take notice that on January 25, 2012, Alliance Pipeline L.P... Pipeline Inc., Managing General Partner of Alliance Pipeline L.P., 800, 605--5 Ave. SW., Calgary, Alberta...; 8:45 am] BILLING CODE 6717-01-P ...

Cutaneous and Mucosal Lichen Planus: A Comprehensive Review of Clinical Subtypes, Risk Factors, Diagnosis, and Prognosis

PubMed Central

2014-01-01

Lichen planus (LP) is a chronic inflammatory disorder that most often affects middle-aged adults. LP can involve the skin or mucous membranes including the oral, vulvovaginal, esophageal, laryngeal, and conjunctival mucosa. It has different variants based on the morphology of the lesions and the site of involvement. The literature suggests that certain presentations of the disease such as esophageal or ophthalmological involvement are underdiagnosed. The burden of the disease is higher in some variants including hypertrophic LP and erosive oral LP, which may have a more chronic pattern. LP can significantly affect the quality of life of patients as well. Drugs or contact allergens can cause lichenoid reactions as the main differential diagnosis of LP. LP is a T-cell mediated immunologic disease but the responsible antigen remains unidentified. In this paper, we review the history, epidemiology, and clinical subtypes of LP. We also review the histopathologic aspects of the disease, differential diagnoses, immunopathogenesis, and the clinical and genetic correlations. PMID:24672362

Consensus guidelines for lumbar puncture in patients with neurological diseases.

PubMed

Engelborghs, Sebastiaan; Niemantsverdriet, Ellis; Struyfs, Hanne; Blennow, Kaj; Brouns, Raf; Comabella, Manuel; Dujmovic, Irena; van der Flier, Wiesje; Frölich, Lutz; Galimberti, Daniela; Gnanapavan, Sharmilee; Hemmer, Bernhard; Hoff, Erik; Hort, Jakub; Iacobaeus, Ellen; Ingelsson, Martin; Jan de Jong, Frank; Jonsson, Michael; Khalil, Michael; Kuhle, Jens; Lleó, Alberto; de Mendonça, Alexandre; Molinuevo, José Luis; Nagels, Guy; Paquet, Claire; Parnetti, Lucilla; Roks, Gerwin; Rosa-Neto, Pedro; Scheltens, Philip; Skårsgard, Constance; Stomrud, Erik; Tumani, Hayrettin; Visser, Pieter Jelle; Wallin, Anders; Winblad, Bengt; Zetterberg, Henrik; Duits, Flora; Teunissen, Charlotte E

2017-01-01

Cerebrospinal fluid collection by lumbar puncture (LP) is performed in the diagnostic workup of several neurological brain diseases. Reluctance to perform the procedure is among others due to a lack of standards and guidelines to minimize the risk of complications, such as post-LP headache or back pain. We provide consensus guidelines for the LP procedure to minimize the risk of complications. The recommendations are based on (1) data from a large multicenter LP feasibility study (evidence level II-2), (2) systematic literature review on LP needle characteristics and post-LP complications (evidence level II-2), (3) discussion of best practice within the Joint Programme Neurodegenerative Disease Research Biomarkers for Alzheimer's disease and Parkinson's Disease and Biomarkers for Multiple Sclerosis consortia (evidence level III). Our consensus guidelines address contraindications, as well as patient-related and procedure-related risk factors that can influence the development of post-LP complications. When an LP is performed correctly, the procedure is well tolerated and accepted with a low complication rate.

Ascorbic acid deficiency in patients with lichen planus.

PubMed

Nicolae, Ilinca; Mitran, Cristina Iulia; Mitran, Madalina Irina; Ene, Corina Daniela; Tampa, Mircea; Georgescu, Simona Roxana

2017-01-01

Recent studies have highlighted the role of oxidative stress in the pathogenesis of lichen planus (LP). In the present study, the interest of the authors is focused on the investigation of ascorbic acid status in patients with LP and identification of parameters that might influence the level of this vitamin. We analyzed the level of urinary ascorbic acid (reflectometric method) in 77 patients with LP (cutaneous LP (CLP)-49 cases; oral LP (OLP)-28 cases) and 50 control subjects. The evaluation of all participants included clinical examination and laboratory and imaging tests. Compared to the control group (19.82 mg/dl) the level of ascorbic acid was significantly lower both in patients with CLP (8.47 mg/dl, p = 0.001) and in those with OLP (8.04 mg/dl, p = 0.001). In patients with LP it was found that the deficiency of ascorbic acid increases with age (r = -0.318, p = 0.032). The urinary concentrations of ascorbic acid were significantly lower in patients with LP associated with infections compared to patients with LP without infections. The urinary ascorbic acid level may be a useful parameter in identifying patients with LP who are at risk of developing viral or bacterial infections.

Roles of the low density lipoprotein receptor and related receptors in inhibition of lipoprotein(a) internalization by proprotein convertase subtilisin/kexin type 9.

PubMed

Romagnuolo, Rocco; Scipione, Corey A; Marcovina, Santica M; Gemin, Matthew; Seidah, Nabil G; Boffa, Michael B; Koschinsky, Marlys L

2017-01-01

Elevated plasma concentrations of lipoprotein(a) (Lp(a)) are a causal risk factor for cardiovascular disease. The mechanisms underlying Lp(a) clearance from plasma remain unclear, which is an obvious barrier to the development of therapies to specifically lower levels of this lipoprotein. Recently, it has been documented that monoclonal antibody inhibitors of proprotein convertase subtilisin/kexin type 9 (PCSK9) can lower plasma Lp(a) levels by 30%. Since PCSK9 acts primarily through the low density lipoprotein receptor (LDLR), this result is in conflict with the prevailing view that the LDLR does not participate in Lp(a) clearance. To support our recent findings in HepG2 cells that the LDLR can act as a bona fide receptor for Lp(a) whose effects are sensitive to PCSK9, we undertook a series of Lp(a) internalization experiments using different hepatic cells, with different variants of PCSK9, and with different members of the LDLR family. We found that PCSK9 decreased Lp(a) and/or apo(a) internalization by Huh7 human hepatoma cells and by primary mouse and human hepatocytes. Overexpression of human LDLR appeared to enhance apo(a)/Lp(a) internalization in both types of primary cells. Importantly, internalization of Lp(a) by LDLR-deficient mouse hepatocytes was not affected by PCSK9, but the effect of PCSK9 was restored upon overexpression of human LDLR. In HepG2 cells, Lp(a) internalization was decreased by gain-of-function mutants of PCSK9 more than by wild-type PCSK9, and a loss-of function variant had a reduced ability to influence Lp(a) internalization. Apo(a) internalization by HepG2 cells was not affected by apo(a) isoform size. Finally, we showed that very low density lipoprotein receptor (VLDLR), LDR-related protein (LRP)-8, and LRP-1 do not play a role in Lp(a) internalization or the effect of PCSK9 on Lp(a) internalization. Our findings are consistent with the idea that PCSK9 inhibits Lp(a) clearance through the LDLR, but do not exclude other effects of PCSK9 such as on Lp(a) biosynthesis.

Roles of the low density lipoprotein receptor and related receptors in inhibition of lipoprotein(a) internalization by proprotein convertase subtilisin/kexin type 9

PubMed Central

Marcovina, Santica M.; Gemin, Matthew; Seidah, Nabil G.; Boffa, Michael B.

2017-01-01

Elevated plasma concentrations of lipoprotein(a) (Lp(a)) are a causal risk factor for cardiovascular disease. The mechanisms underlying Lp(a) clearance from plasma remain unclear, which is an obvious barrier to the development of therapies to specifically lower levels of this lipoprotein. Recently, it has been documented that monoclonal antibody inhibitors of proprotein convertase subtilisin/kexin type 9 (PCSK9) can lower plasma Lp(a) levels by 30%. Since PCSK9 acts primarily through the low density lipoprotein receptor (LDLR), this result is in conflict with the prevailing view that the LDLR does not participate in Lp(a) clearance. To support our recent findings in HepG2 cells that the LDLR can act as a bona fide receptor for Lp(a) whose effects are sensitive to PCSK9, we undertook a series of Lp(a) internalization experiments using different hepatic cells, with different variants of PCSK9, and with different members of the LDLR family. We found that PCSK9 decreased Lp(a) and/or apo(a) internalization by Huh7 human hepatoma cells and by primary mouse and human hepatocytes. Overexpression of human LDLR appeared to enhance apo(a)/Lp(a) internalization in both types of primary cells. Importantly, internalization of Lp(a) by LDLR-deficient mouse hepatocytes was not affected by PCSK9, but the effect of PCSK9 was restored upon overexpression of human LDLR. In HepG2 cells, Lp(a) internalization was decreased by gain-of-function mutants of PCSK9 more than by wild-type PCSK9, and a loss-of function variant had a reduced ability to influence Lp(a) internalization. Apo(a) internalization by HepG2 cells was not affected by apo(a) isoform size. Finally, we showed that very low density lipoprotein receptor (VLDLR), LDR-related protein (LRP)-8, and LRP-1 do not play a role in Lp(a) internalization or the effect of PCSK9 on Lp(a) internalization. Our findings are consistent with the idea that PCSK9 inhibits Lp(a) clearance through the LDLR, but do not exclude other effects of PCSK9 such as on Lp(a) biosynthesis. PMID:28750079

Consuming Lower-Protein Nutrition Bars with Added Leucine Elicits Postprandial Changes in Appetite Sensations in Healthy Women.

PubMed

Bolster, Douglas R; Rahn, Maike; Kamil, Alison G; Bristol, Lindsey T; Goltz, Shellen R; Leidy, Heather J; Blaze Mt, Melvin; Nunez, Michael A; Guo, Elizabeth; Wang, Jianquan; Harkness, Laura S

2018-04-20

Higher-protein meals (>25 g protein/meal) have been associated with enhanced satiety but the role of amino acids is unclear. Leucine has been proposed to stimulate satiety in rodents but has not been assessed in humans. We assessed the acute effects of lower-protein nutrition bars, enhanced with a leucine peptide (LP), on postprandial appetite sensations in combination with plasma leucine and peptide YY (PYY) in healthy women. Utilizing a double-blind randomized crossover design, 40 healthy women [28 ± 7.5 y; body mass index (BMI, in kg/m2): 23.5 ± 2.4] consumed the following isocaloric (180 kcal) pre-loads on 3 separate visits: control bar [9 g protein with 0 g added LP (0-g LP)] or treatment bars [11 g protein with 2 g added LP (2-g LP) or 13 g protein with 3 g added LP (3-g LP)]. Pre- and postprandial hunger, desire to eat, prospective food consumption (PFC), fullness, and plasma leucine were assessed every 30 min for 240 min. Plasma PYY was assessed hourly for 240 min (n = 24). Main effects of time (P < 0.0001) and treatment (P < 0.03) were detected for postprandial hunger, desire to eat, PFC, and fullness. Post hoc analyses revealed that the 2-g and 3-g LP bars elicited greater increases in fullness and greater decreases in PFC compared with 0-g LP (all, P < 0.05) with no differences between the 2-g and 3-g LP bars. The 2-g bar elicited greater decreases in hunger and desire to eat compared with the 0-g LP bar (both, P ≤ 0.01), whereas 3-g LP did not. Appetite incremental areas under the curves (iAUCs) and PYY outcomes were not different between bars. A treatment × time interaction was detected for plasma leucine with increases occurring in a leucine-dose-dependent manner (P < 0.0001). Despite the dose-dependent increases in plasma leucine following the consumption of lower-protein bars enhanced with LP, only the 2-g LP bar elicited consistent postprandial changes in select appetite sensations compared with the 0-g LP bar. This study was registered on clinicaltrials.gov as NCT02091570.

75 FR 38514 - Application to Export Electric Energy; Brookfield Energy Marketing LP

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-02

... Energy Marketing LP AGENCY: Office of Electricity Delivery and Energy Reliability, DOE. ACTION: Notice of application. SUMMARY: Brookfield Energy Marketing LP (BEM LP) has applied for authority to transmit electric... surplus energy purchased from electric utilities, Federal power marketing agencies and other entities...

78 FR 11567 - Airworthiness Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-19

... Airworthiness Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel Aircraft... Aerospace LP (Type Certificate Previously Held by Israel Aircraft Industries, Ltd.) Model Gulfstream G150... Gulfstream Aerospace LP (Type Certificate Previously Held by Israel Aircraft Industries, Ltd.): Amendment 39...

Centrifugal reciprocating compressor

NASA Technical Reports Server (NTRS)

High, W. H.

1980-01-01

Efficient compressor uses centrifugal force to compress gas. System incorporates two coupled dc motors, each driving separate centrifugal reciprocating-compressor assembly. Motors are synchronized to accelerate and decelerate alternately.

76 FR 52654 - Millennium Pipeline Company, LLC; Notice of Intent To Prepare an Environmental Assessment for the...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-23

... proposes to construct and operate one new compressor station in Minisink, New York. The Minisink Compressor... at the new Minisink Compressor Station; Approximately 1,090 feet of 36-inch-diameter pipeline for... would be maintained permanently for operation of the Minisink Compressor Station. The EA Process The...

Development of a High Efficiency Compressor/Expander for an Air Cycle Air Conditioning System.

DTIC Science & Technology

1982-11-15

bearing, lb PHUB - Hub pressure (initial guess), psia RLG - Rotor length 1 ’B-2 RPM - Rotational speed, RPM R - Gas constant, lb -ft/lb - R CP - Specific...Compressor discharge port pressure ratio (PCD/PC2).:- CDP - Compressor pressure change, PCD-PCl PHUB - Pressure in compressor hub (acting on base of vanes

R-189 (C-620) air compressor control logic software documentation. Revision 1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Walter, K.E.

1995-06-08

This relates to FFTF plant air compressors. Purpose of this document is to provide an updated Computer Software Description for the software to be used on R-189 (C-620-C) air compressor programmable controllers. Logic software design changes were required to allow automatic starting of a compressor that had not been previously started.

Fast 4-2 Compressor of Booth Multiplier Circuits for High-Speed RISC Processor

NASA Astrophysics Data System (ADS)

Yuan, S. C.

2008-11-01

We use different XOR circuits to optimize the XOR structure 4-2 compressor, and design the transmission gates(TG) 4-2 compressor use single to dual rail circuit configurations. The maximum propagation delay, the power consumption and the layout area of the designed 4-2 compressors are simulated with 0.35μm and 0.25μm CMOS process parameters and compared with results of the synthesized 4-2 circuits, and show that the designed 4-2 compressors are faster and area smaller than the synthesized one.

Determination of Pressure Fluctuations in Rotor Bundle of Centrifugal Compressor at Critical Conditions of Operation

NASA Astrophysics Data System (ADS)

Levashov, V. A.; Lyubchenko, K. Yu

2017-08-01

This article describes the physical processes that occur in the stage flow part of the compressor while it is operating and can create conditions for the occurrence of forced vibrations, which in turn can lead to the destruction of the impellers. Critical conditions of compressor operation are determined. To understand that critical condition of operation is cause of the destruction of the impellers, transient CFD analysis was carried for test stage of compressor. The obtained pressure fluctuation amplitudes allow to evaluate the critical conditions of compressor operation.

Possibility of Thermomechanical Compressor Application in Desalination Plants

NASA Astrophysics Data System (ADS)

Blagin, E. V.; Shimanov, A. A.; Uglanov, D. A.; Korneev, S. S.

2018-01-01

This article deals with estimation of thermocompressor operating possibility in desalination plant with mechanical vapour compressor. In this plant thermocompressor is used instead of commonly used centrifugal compressor. Preliminary analysis shows that such plant is able to operate, however, power consumption is 3.5-6.5 higher in comparison with traditional MVC plant. In turn, utilization of thermocompressor allows avoiding usual high-frequency drive of centrifugal compressor. Drives with frequency of 50 Hz are enough for thermocompressor when centrifugal compressor requires drives with frequency up to 500 Hz and higher. Approximate thermocompressor dimensions are estimated.

NASA Environmentally Responsible Aviation High Overall Pressure Ratio Compressor Research Pre-Test CFD

NASA Technical Reports Server (NTRS)

Celestina, Mark L.; Fabian, John C.; Kulkarni, Sameer

2012-01-01

This paper describes a collaborative and cost-shared approach to reducing fuel burn under the NASA Environmentally Responsible Aviation project. NASA and General Electric (GE) Aviation are working together aa an integrated team to obtain compressor aerodynamic data that is mutually beneficial to both NASA and GE Aviation. The objective of the High OPR Compressor Task is to test a single stage then two stages of an advanced GE core compressor using state-of-the-art research instrumentation to investigate the loss mechanisms and interaction effects of embedded transonic highly-loaded compressor stages. This paper presents preliminary results from NASA's in-house multistage computational code, APNASA, in preparation for this advanced transonic compressor rig test.

Is Lp(a) ready for prime time use in the clinic? A pros-and-cons debate.

PubMed

Kostner, Karam M; Kostner, Gert M; Wierzbicki, Anthony S

2018-04-30

Lipoprotein (a) (Lp(a)) is a cholesterol-rich lipoprotein known since 1963. In spite of extensive research on Lp(a), there are still numerous gaps in our knowledge relating to its function, biosynthesis and catabolism. One reason for this might be that apo(a), the characteristic glycoprotein of Lp(a), is expressed only in primates. Results from experiments using transgenic animals therefore may need verification in humans. Studies on Lp(a) are also handicapped by the great number of isoforms of apo(a) and the heterogeneity of apo(a)-containing fractions in plasma. Quantification of Lp(a) in the clinical laboratory for a long time has not been standardized. Starting from its discovery, reports accumulated that Lp(a) contributed to the risk of cardiovascular disease (CVD), myocardial infarction (MI) and stroke. Early reports were based on case control studies but in the last decades a great deal of prospective studies have been published that highlight the increased risk for CVD and MI in patients with elevated Lp(a). Final answers to the question of whether Lp(a) is ready for wider clinical use will come from intervention studies with novel selective Lp(a) lowering medications that are currently underway. This article expounds arguments for and against this proposition from currently available data. Copyright © 2018 Elsevier B.V. All rights reserved.

Lactobacillus paracasei metabolism of rice bran reveals metabolome associated with Salmonella Typhimurium growth reduction.

PubMed

Nealon, N J; Worcester, C R; Ryan, E P

2017-06-01

This study aimed to determine the effect of a cell-free supernatant of Lactobacillus paracasei ATCC 27092 with and without rice bran extract (RBE) on Salmonella Typhimurium 14028s growth, and to identify a metabolite profile with antimicrobial functions. Supernatant was collected from overnight cultures of L. paracasei incubated in the presence (LP+RBE) or absence (LP) of RBE and applied to S. Typhimurium. LP+RBE reduced 13·1% more S. Typhimurium growth than LP after 16 h (P < 0·05). Metabolite profiles of LP and LP+RBE were examined using nontargeted global metabolomics consisting of ultra-high-performance liquid chromatography coupled with tandem mass spectrometry. A comparison of LP and LP+RBE revealed 84 statistically significant metabolites (P < 0·05), where 20 were classified with antimicrobial functions. LP+RBE reduced S. Typhimurium growth to a greater extent than LP, and the metabolite profile distinctions suggested that RBE favourably modulates the metabolism of L. paracasei. These findings warrant continued investigation of probiotic and RBE antimicrobial activities across microenvironments and matrices where S. Typhimurium exposure is problematic. This study showed a novel metabolite profile of probiotic L. paracasei and prebiotic rice bran that increased antimicrobial activity against S. Typhimurium. © 2017 The Authors. Journal of Applied Microbiology published by John Wiley & Sons Ltd on behalf of The Society for Applied Microbiology.

Large particle breakdown by cattle eating ryegrass and alfalfa.

PubMed

McLeod, M N; Minson, D J

1988-04-01

The proportion of large particles (LP) broken down to small, insoluble particles by primary mastication (eating), rumination, digestion and detrition (rubbing) was determined for separated leaf and stem fractions of perennial ryegrass (Lolium perenne) and alfalfa (Medicago sativa) fed to cattle cannulated at the esophagus. Large particles were defined as those particles retained during wet sieving on a screen with an aperture of 1.18 mm. Reduction in weight of particles caused by solubilizing or digestion was not considered to be particle breakdown per se, and particles were corrected for this loss in weight. The proportion of LP in the forage broken down by primary mastication was 25 +/- 1.9% (means +/- SE). Breakdown of LP by rumination was calculated from the weight of total particles regurgitated and the proportion of LP in the regurgitated and swallowed remasticated material. The weight of LP regurgitated was corrected for the dry matter lost by digestion using lignin ratio in the LP entering the rumen and of the regurgitated digesta. Rumination accounted for 50 +/- 1.5% of LP breakdown. Fecal loss accounted for 8 +/- .8% of the LP in forage. Breakdown of LP by digestion and detrition was calculated as 17 +/- 1.3% from the difference between the LP eaten and those broken down by primary mastication, rumination and passing out in the feces. The significance of these results for predicting voluntary intake from laboratory analysis is considered.

The Lipid Parameters and Lipoprotein(a) Excess in Hashimoto Thyroiditis.

PubMed

Yetkin, D O; Dogantekin, B

2015-01-01

Objective. The risk of atherosclerotic heart disease is increased in autoimmune thyroiditis, although the reason is not clear. Lipoprotein(a) (Lp(a)) excess has been identified as a powerful predictor of premature atherosclerotic vascular diseases. The aim of this study is to investigate the relationship between Lp(a) levels and thyroid hormones in Hashimoto patients. Method. 154 premenopausal female Hashimoto patients (48 patients with overthypothyroid (OH), 50 patients with subclinical hypothyroid (SH), and 56 patients with euthyroid Hashimoto to (EH)) were enrolled in this study. The control group consists of 50 age matched volunteers. In every group, thyroid function tests and lipid parameters with Lp(a) were measured. Lp(a) excess was defined as Lp(a) > 30 mg/dL. Results. Total-C, LDL-C, TG, and Lp(a) levels were increased in Hashimoto group. Total-C, LDL-C, and TG levels were higher in SH group than in the control group. Total-C and LDL-C levels were also higher in EH group compared to controls. Lp(a) levels were similar in SH and EH groups with controls. However, excess Lp(a) was more common in subclinical hypothyroid and euthyroid Hashimoto group than in the control group. Conclusion. The Total-C and LDL-C levels and excess Lp(a) were higher even in euthyroid Hashimoto patients. Thyroid autoimmunity may have some effect on Lp(a) and lipid metabolism.

The Lipid Parameters and Lipoprotein(a) Excess in Hashimoto Thyroiditis

PubMed Central

Yetkin, D. O.; Dogantekin, B.

2015-01-01

Objective. The risk of atherosclerotic heart disease is increased in autoimmune thyroiditis, although the reason is not clear. Lipoprotein(a) (Lp(a)) excess has been identified as a powerful predictor of premature atherosclerotic vascular diseases. The aim of this study is to investigate the relationship between Lp(a) levels and thyroid hormones in Hashimoto patients. Method. 154 premenopausal female Hashimoto patients (48 patients with overthypothyroid (OH), 50 patients with subclinical hypothyroid (SH), and 56 patients with euthyroid Hashimoto to (EH)) were enrolled in this study. The control group consists of 50 age matched volunteers. In every group, thyroid function tests and lipid parameters with Lp(a) were measured. Lp(a) excess was defined as Lp(a) > 30 mg/dL. Results. Total-C, LDL-C, TG, and Lp(a) levels were increased in Hashimoto group. Total-C, LDL-C, and TG levels were higher in SH group than in the control group. Total-C and LDL-C levels were also higher in EH group compared to controls. Lp(a) levels were similar in SH and EH groups with controls. However, excess Lp(a) was more common in subclinical hypothyroid and euthyroid Hashimoto group than in the control group. Conclusion. The Total-C and LDL-C levels and excess Lp(a) were higher even in euthyroid Hashimoto patients. Thyroid autoimmunity may have some effect on Lp(a) and lipid metabolism. PMID:26064115

Immune-Enhancing Effect of Nanometric Lactobacillus plantarum nF1 (nLp-nF1) in a Mouse Model of Cyclophosphamide-Induced Immunosuppression.

PubMed

Choi, Dae-Woon; Jung, Sun Young; Kang, Jisu; Nam, Young-Do; Lim, Seong-Il; Kim, Ki Tae; Shin, Hee Soon

2018-02-28

Nanometric Lactobacillus plantarum nF1 (nLp-nF1) is a biogenics consisting of dead L. plantarum cells pretreated with heat and a nanodispersion process. In this study, we investigated the immune-enhancing effects of nLp-nF1 in vivo and in vitro. To evaluate the immunostimulatory effects of nLp-nF1, mice immunosuppressed by cyclophosphamide (CPP) treatment were administered with nLp-nF1. As expected, CPP restricted the immune response of mice, whereas oral administration of nLp-nF1 significantly increased the total IgG in the serum, and cytokine production (interleukin-12 (IL-12) and tumor necrosis factor alpha (TNF-α)) in bone marrow cells. Furthermore, nLp-nF1 enhanced the production of splenic cytokines such as IL-12, TNF-α, and interferon gamma (IFN-γ). In vitro, nLp-nF1 stimulated the immune response by enhancing the production of cytokines such as IL-12, TNF-α, and IFN-γ. Moreover, nLp-nF1 given a food additive enhanced the immune responses when combined with various food materials in vitro. These results suggest that nLp-nF1 could be used to strengthen the immune system and recover normal immunity in people with a weak immune system, such as children, the elderly, and patients.

Update on Risk Reduction Activities for a Liquid Advanced Booster for NASA's Space Launch System

NASA Technical Reports Server (NTRS)

Crocker, Andy; Greene, William D.

2017-01-01

Goals of NASA's Advanced Booster Engineering Demonstration and/or Risk Reduction (ABEDRR) are to: (1) Reduce risks leading to an affordable Advanced Booster that meets the evolved capabilities of SLS. (2) Enable competition by mitigating targeted Advanced Booster risks to enhance SLS affordability. SLS Block 1 vehicle is being designed to carry 70 mT to LEO: (1) Uses two five-segment solid rocket boosters (SRBs) similar to the boosters that helped power the space shuttle to orbit. Evolved 130 mT payload class rocket requires an advanced booster with more thrust than any existing U.S. liquid-or solid-fueled boosters

Diagnostic classification of eating disorders in children and adolescents: How does DSM-IV-TR compare to empirically-derived categories?

PubMed Central

Eddy, Kamryn T.; le Grange, Daniel; Crosby, Ross D.; Hoste, Renee Rienecke; Doyle, Angela Celio; Smyth, Angela; Herzog, David B.

2009-01-01

Objective The purpose of this study was to empirically derive eating disorder phenotypes in a clinical sample of children and adolescents using latent profile analysis (LPA) and compare these latent profile (LP) groups to the DSM-IV-TR eating disorder categories. Method Eating disorder symptom data collected from 401 youth (ages 7–19; mean 15.14 ± 2.35y) seeking eating disorder treatment were included in LPA; general linear models were used to compare LP groups to DSM-IV-TR eating disorder categories on pre-treatment and outcome indices. Results Three LP groups were identified: LP1 (n=144), characterized binge eating and purging (“Binge/purge”); LP2 (n=126), characterized by excessive exercise and extreme eating disorder cognitions (“Exercise-extreme cognitions”); and LP3 (n=131), characterized by minimal eating disorder behaviors and cognitions (“Minimal behaviors/cognitions”). Identified LPs imperfectly resembled DSM-IV-TR eating disorders. LP1 resembled bulimia nervosa; LP2 and LP3 broadly resembled anorexia nervosa with a relaxed weight criterion, differentiated by excessive exercise and severity of eating disorder cognitions. LP groups were more differentiated than the DSM-IV-TR categories across pre-treatment eating disorder and general psychopathology indices, as well as weight change at follow-up. Neither LP nor DSM-IV-TR categories predicted change in binge/purge behaviors. Validation analyses suggest these empirically-derived groups improve upon the current DSM-IV-TR categories. Conclusions In children and adolescents, revisions for DSM-V should consider recognition of patients with minimal cognitive eating disorder symptoms. PMID:20410717

78 FR 53487 - Equinox Funds Trust and Equinox Institutional Asset Management LP; Notice of Application

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-29

... Funds Trust and Equinox Institutional Asset Management LP; Notice of Application August 23, 2013. AGENCY...: Equinox Funds Trust (the ``Trust'') and Equinox Institutional Asset Management LP (the ``Initial Adviser... Institutional Asset Management LP, 47 Hulfish Street, Suite 510, Princeton, NJ 08542; Daniel Prezioso, Equinox...

75 FR 26255 - Change in Bank Control Notices; Acquisition of Shares of Bank or Bank Holding Companies

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-11

... Street, San Francisco, California 94105-1579: 1. Thomas H. Lee Equity Fund VI, L.P.; Thomas H. Lee Parallel Fund VI, L.P.; Thomas H. Lee Parallel (DT) Fund VI, L.P.; and THL Sterling Equity Investors, L.P...

47 CFR 27.9 - Operation of certificated signal boosters.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 47 Telecommunication 2 2013-10-01 2013-10-01 false Operation of certificated signal boosters. 27.9... boosters. Individuals and non-individuals may operate certificated Consumer Signal Boosters on frequencies... operate a signal booster. [78 FR 21564, Apr. 11, 2013] ...

47 CFR 27.9 - Operation of certificated signal boosters.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 47 Telecommunication 2 2014-10-01 2014-10-01 false Operation of certificated signal boosters. 27.9... boosters. Individuals and non-individuals may operate certificated Consumer Signal Boosters on frequencies... operate a signal booster. [78 FR 21564, Apr. 11, 2013] ...

Performance of the active sidewall boundary-layer removal system for the Langley 0.3-meter Transonic Cryogenic Tunnel

NASA Technical Reports Server (NTRS)

Balakrishna, S.; Kilgore, W. Allen; Murthy, A. V.

1989-01-01

A performance evaluation of an active sidewall boundary-layer removal system for the Langley 0.3-m Transonic Cryogenic Tunnel (TCT) was evaluated in 1988. This system uses a compressor and two throttling digital valves to control the boundary-layer mass flow removal from the tunnel. The compressor operates near the maximum pressure ratio for all conditions. The system uses a surge prevention and flow recirculation scheme. A microprocessor based controller is used to provide the necessary mass flow and compressor pressure ratio control. Initial tests on the system indicated problems in realizing smooth mass flow control while running the compressor at high speed and high pressure ratios. An alternate method has been conceived to realize boundary-layer mass flow control which avoids the recirculation of the compressor mass flow and operation near the compressor surge point. This scheme is based on varying the speed of the compressor for a sufficient pressure ratio to provide needed mass flow removal. The system has a mass flow removal capability of about 10 percent of test section flow at M = 0.3 and 4 percent at M = 0.8. The system performance has been evaluated in the form of the compressor map, and compressor tunnel interface characteristics covering most of the 0.3-m TCT operational envelope.

Performance Testing of Jefferson Lab 12 GeV Helium Screw Compressors

DOE PAGES

Knudsen, P.; Ganni, V.; Dixon, K.; ...

2015-08-10

Oil injected screw compressors have essentially superseded all other types of compressors in modern helium refrigeration systems due to their large displacement capacity, reliability, minimal vibration, and capability of handling helium's high heat of compression. At the present state of compressor system designs for helium refrigeration systems, typically two-thirds of the lost input power is due to the compression system. It is important to understand the isothermal and volumetric efficiencies of these machines to help properly design the compression system to match the refrigeration process. It is also important to identify those primary compressor skid exergetic loss mechanisms which maymore » be reduced, thereby offering the possibility of significantly reducing the input power to helium refrigeration processes which are extremely energy intensive. This paper summarizes the results collected during the commissioning of the new compressor system for Jefferson Lab's (JLab's) 12 GeV upgrade. The compressor skid packages were designed by JLab and built to print by industry. They incorporate a number of modifications not typical of helium screw compressor packages and most importantly allow a very wide range of operation so that JLab's patented Floating Pressure Process can be fully utilized. This paper also summarizes key features of the skid design that allow this process and facilitate the maintenance and reliability of these helium compressor systems.« less

Performance Testing of Jefferson Lab 12 GeV Helium Screw Compressors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Knudsen, P.; Ganni, V.; Dixon, K.

Oil injected screw compressors have essentially superseded all other types of compressors in modern helium refrigeration systems due to their large displacement capacity, reliability, minimal vibration, and capability of handling helium's high heat of compression. At the present state of compressor system designs for helium refrigeration systems, typically two-thirds of the lost input power is due to the compression system. It is important to understand the isothermal and volumetric efficiencies of these machines to help properly design the compression system to match the refrigeration process. It is also important to identify those primary compressor skid exergetic loss mechanisms which maymore » be reduced, thereby offering the possibility of significantly reducing the input power to helium refrigeration processes which are extremely energy intensive. This paper summarizes the results collected during the commissioning of the new compressor system for Jefferson Lab's (JLab's) 12 GeV upgrade. The compressor skid packages were designed by JLab and built to print by industry. They incorporate a number of modifications not typical of helium screw compressor packages and most importantly allow a very wide range of operation so that JLab's patented Floating Pressure Process can be fully utilized. This paper also summarizes key features of the skid design that allow this process and facilitate the maintenance and reliability of these helium compressor systems.« less

Axial and Centrifugal Compressor Mean Line Flow Analysis Method

NASA Technical Reports Server (NTRS)

Veres, Joseph P.

2009-01-01

This paper describes a method to estimate key aerodynamic parameters of single and multistage axial and centrifugal compressors. This mean-line compressor code COMDES provides the capability of sizing single and multistage compressors quickly during the conceptual design process. Based on the compressible fluid flow equations and the Euler equation, the code can estimate rotor inlet and exit blade angles when run in the design mode. The design point rotor efficiency and stator losses are inputs to the code, and are modeled at off design. When run in the off-design analysis mode, it can be used to generate performance maps based on simple models for losses due to rotor incidence and inlet guide vane reset angle. The code can provide an improved understanding of basic aerodynamic parameters such as diffusion factor, loading levels and incidence, when matching multistage compressor blade rows at design and at part-speed operation. Rotor loading levels and relative velocity ratio are correlated to the onset of compressor surge. NASA Stage 37 and the three-stage NASA 74-A axial compressors were analyzed and the results compared to test data. The code has been used to generate the performance map for the NASA 76-B three-stage axial compressor featuring variable geometry. The compressor stages were aerodynamically matched at off-design speeds by adjusting the variable inlet guide vane and variable stator geometry angles to control the rotor diffusion factor and incidence angles.

Investigation of H2 Diaphragm Compressors to Enable Low-Cost Long-Life Operation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rohatgi, Aashish; Johnson, Kenneth I.

2013-12-01

This is a “short” annual report to DOE Fuel Cell Technology Office describing the research on modeling and materials analysis of diaphragms in a diaphragm-type hydrogen compressor. The compressor design details and diaphragm materials were provided by PDC Machines, Inc., a commercial manufacturer of diaphragm-type hydrogen compressors that PNNL is partnering with in this project

Experimental Investigation of Diffuser Hub Injection to Improve Centrifugal Compressor Stability

NASA Technical Reports Server (NTRS)

Skoch, Gary J.

2004-01-01

Results from a series of experiments to investigate whether centrifugal compressor stability could be improved by injecting air through the diffuser hub surface are reported. The research was conducted in a 4:1 pressure ratio centrifugal compressor configured with a vane-island diffuser. Injector nozzles were located just upstream of the leading edge of the diffuser vanes. Nozzle orientations were set to produce injected streams angled at 8, 0 and +8 degrees relative to the vane mean camber line. Several injection flow rates were tested using both an external air supply and recirculation from the diffuser exit. Compressor flow range did not improve at any injection flow rate that was tested. Compressor flow range did improve slightly at zero injection due to the flow resistance created by injector openings on the hub surface. Leading edge loading and semi-vaneless space diffusion showed trends similar to those reported earlier from shroud surface experiments that did improve compressor flow range. Opposite trends are seen for hub injection cases where compressor flow range decreased. The hub injection data further explain the range improvement provided by shroud-side injection and suggest that different hub-side techniques may produce range improvement in centrifugal compressors.

The results of pre-design studies on the development of a new design of gas turbine compressor package of GPA-C-16 type

NASA Astrophysics Data System (ADS)

Smirnov, A. V.; Chobenko, V. M.; Shcherbakov, O. M.; Ushakov, S. M.; Parafiynyk, V. P.; Sereda, R. M.

2017-08-01

The article summarizes the results of analysis of data concerning the operation of turbocompressor packages at compressor stations for the natural gas transmission system of Ukraine. The basic requirements for gas turbine compressor packages used for modernization and reconstruction of compressor stations are considered. Using a 16 MW gas turbine package GPA-C-16S/76-1,44M1 as an example, the results of pre-design studies and some technical solutions that improve the energy efficiency of gas turbine compressor packages and their reliability, as well as its environmental performance are given. In particular, the article deals with the matching of performance characteristics of a centrifugal compressor (hereinafter compressor) and gas turbine drive to reduce fuel gas consumption; as well as application of energy efficient technologies, in particular, exhaust gas heat recovery units and gas-oil heat exchangers in turbocompressor packages oil system; as well as reducing emissions of carbon monoxide into the atmosphere using a catalytic exhaust system. Described technical solutions can be used for development of other types of gas turbine compressor packages.

Axial inlet conversion to a centrifugal compressor with magnetic bearings

DOE Office of Scientific and Technical Information (OSTI.GOV)

Novecosky, T.

1994-01-01

NOVA's Alberta Gas Transmission Division transports natural gas via pipeline throughout the province of Alberta, Canada, exporting it to eastern Canada, US, and British Columbia. There is a continuing effort to operate the facilities and pipeline at the highest possible efficiency. One area being addressed to improve efficiency is compression of the gas. By improving compressor efficiency, fuel consumption and hence operating costs can be reduced. One method of improving compressor efficiency is by converting the compressor to an axial inlet configuration, a conversion that has been carried out more frequently in the past years. Concurrently, conventional hydrodynamic bearings havemore » been replaced with magnetic bearings on many centrifugal compressors. This paper discusses the design and installation for converting a radial overhung unit to an axial inlet configuration, having both magnetic bearings and a thrust reducer. The thrust reducer is required to reduce axial compressor shaft loads, to a level that allows the practical installation of magnetic bearings within the space limitations of the compressor (Bear and Gibson, 1992).« less

Prediction of active control of subsonic centrifugal compressor rotating stall

NASA Technical Reports Server (NTRS)

Lawless, Patrick B.; Fleeter, Sanford

1993-01-01

A mathematical model is developed to predict the suppression of rotating stall in a centrifugal compressor with a vaned diffuser. This model is based on the employment of a control vortical waveform generated upstream of the impeller inlet to damp weak potential disturbances that are the early stages of rotating stall. The control system is analyzed by matching the perturbation pressure in the compressor inlet and exit flow fields with a model for the unsteady behavior of the compressor. The model was effective at predicting the stalling behavior of the Purdue Low Speed Centrifugal Compressor for two distinctly different stall patterns. Predictions made for the effect of a controlled inlet vorticity wave on the stability of the compressor show that for minimum control wave magnitudes, on the order of the total inlet disturbance magnitude, significant damping of the instability can be achieved. For control waves of sufficient amplitude, the control phase angle appears to be the most important factor in maintaining a stable condition in the compressor.

Core compressor exit stage study, 2

NASA Technical Reports Server (NTRS)

Behlke, R. F.; Burdsall, E. A.; Canal, E., Jr.; Korn, N. D.

1979-01-01

A total of two three-stage compressors were designed and tested to determine the effects of aspect ratio on compressor performance. The first compressor was designed with an aspect ratio of 0.81; the other, with an aspect ratio of 1.22. Both compressors had a hub-tip ratio of 0.915, representative of the rear stages of a core compressor, and both were designed to achieve a 15.0% surge margin at design pressure ratios of 1.357 and 1.324, respectively, at a mean wheel speed of 167 m/sec. At design speed the 0.81 aspect ratio compressor achieved a pressure ratio of 1.346 at a corrected flow of 4.28 kg/sec and an adiabatic efficiency of 86.1%. The 1.22 aspect ratio design achieved a pressure ratio of 1.314 at 4.35 kg/sec flow and 87.0% adiabatic efficiency. Surge margin to peak efficiency was 24.0% with the lower aspect ratio blading, compared with 12.4% with the higher aspect ratio blading.

Impact of inlet coherent motions on compressor performance

NASA Astrophysics Data System (ADS)

Forlese, Jacopo; Spoleti, Giovanni

2017-08-01

Automotive engine induction systems may be characterized by significant flow angularity and total pressure distortion at the compressor inlet. The impact of the swirl on compressor performance should be quantified to guide the design of the induction systems. In diesel engines, the presence of a valve for flow reduction and control of low pressure EGR recirculation could generate coherent motion and influence the performance of the compressor. Starting from experimental map, the compressor speed-lines have been simulated using a 3D CFD commercial code imposing different concept motion at the inlet. The swirl intensity, the direction and the number of vortices have been imposed in order to taking into account some combinations. Finally, a merit function has been defined to evaluate the performance of the compressor with the defined swirl concepts. The aim of the current work is to obtain an indication on the effect of a swirling motion at the compressor inlet on the engine performance and provide a guideline to the induction system design.

The Supersonic Axial-Flow Compressor

NASA Technical Reports Server (NTRS)

Kantrowitz, Arthur

1950-01-01

An investigation has been made to explore the possibilities of axial-flow compressors operating with supersonic velocities into the blade rows. Preliminary calculations showed that very high pressure ratios across a stage, together with somewhat increased mass flows, were apparently possible with compressors which decelerated air through the speed of sound in their blading. The first phase of the investigation was the development of efficient supersonic diffusers to decelerate air through the speed of sound. The present report is largely a general discussion of some of the essential aerodynamics of single-stage supersonic axial-flow compressors. As an approach to the study of supersonic compressors, three possible velocity diagrams are discussed briefly. Because of the encouraging results of this study, an experimental single-stage supersonic compressor has been constructed and tested in Freon-12. In this compressor, air decelerates through the speed of sound in the rotor blading and enters the stators at subsonic speeds. A pressure ratio of about 1.8 at an efficiency of about 80 percent has been obtained.

Aerodynamic Design of a Four-Stage Low-Speed Axial Compressor for Cantilevered Stator Research

NASA Astrophysics Data System (ADS)

Wallace, James N.

This research is focused on the baseline aerodynamic design of a four-stage low-speed axial compressor with the intent to achieve similarity of cantilevered stator hub leakage flows with those in the rear stages of Siemens large gas turbine compressors. The baseline airfoil design is to act as a comparison for all future research completed in the low speed compressor and, therefore, will not include possible future research topics such as 3-D airfoil geometry or end-wall contouring. Following the design of the airfoils is the aerodynamic design of the facility including the inlet and exhaust. These components were designed to eliminate interactions of the compressor with the facility and to accommodate instrumentation. A baseline set of aerodynamic instrumentation is then suggested to characterize compressor performance. Fully 3-D steady CFD was used extensively during the design of both the facility and the compressor, as well as determining the locations and types of instrumentation.

Development of Carbon Dioxide Hermitic Compressor

NASA Astrophysics Data System (ADS)

Imai, Satoshi; Oda, Atsushi; Ebara, Toshiyuki

Because of global environmental problems, the existing refrigerants are to be replaced with natural refrigerants. CO2 is one of the natural refrigerants and environmentally safe, inflammable and non-toxic refrigerant. Therefore high efficiency compressor that can operate with natural refrigerants, especially CO2, needs to be developed. We developed a prototype CO2 hermetic compressor, which is able to use in carbon dioxide refrigerating systems for practical use. The compressor has two rolling pistons, and it leads to low vibrations, low noise. In additions, two-stage compression with two cylinders is adopted, because pressure difference is too large to compress in one stage. And inner pressure of the shell case is intermediate pressure to minimize gas leakage between compressing rooms and inner space of shell case. Intermediate pressure design enabled to make the compressor smaller in size and lighter in weight. As a result, the compressor achieved high efficiency and high reliability by these technology. We plan to study heat pump water heater, cup vending machine and various applications with CO2 compressor.

ANALYTICAL AND EXPERIMENTAL INVESTIGATION OF ROTATING STALL PHENOMENA IN TURBINE ENGINE COMPRESSORS.

DTIC Science & Technology

AXIAL FLOW COMPRESSORS, STALLING), TURBOJET ENGINES , AXIAL FLOW COMPRESSOR BLADES , LIFT, HYSTERESIS, TURBULENCE, INLET GUIDE VANES , RINGS, STABILITY, THREE DIMENSIONAL FLOW, VISCOSITY, VORTICES, FLUIDICS.

49 CFR 192.173 - Compressor stations: Ventilation.

Code of Federal Regulations, 2010 CFR

2010-10-01

... NATURAL AND OTHER GAS BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Design of Pipeline Components § 192.173 Compressor stations: Ventilation. Each compressor station building must be ventilated to ensure...

Lipoprotein(a): Biology and Clinical Importance

PubMed Central

McCormick, Sally P A

2004-01-01

Lipoprotein(a) [Lp(a)] is a unique lipoprotein that has emerged as an independent risk factor for developing vascular disease. Plasma Lp(a) levels above the common cut-off level of 300 mg/L place individuals at risk of developing heart disease particularly if combined with other lipid and thrombogenic risk factors. Studies in humans have shown Lp(a) levels to be hugely variable and under strict genetic control, largely by the apolipoprotein(a) [apo(a)] gene. In general, Lp(a) levels have proven difficult to manipulate, although some factors have been identified that can influence levels. Research has shown that Lp(a) has a high affinity for the arterial wall and displays many athero-thrombogenic properties. While a definite function for Lp(a) has not been identified, the last two decades of research have provided much information on the biology and clinical importance of Lp(a). PMID:18516206

Serum lipoprotein (a) concentrations among Arab children: a hospital-based study in Kuwait.

PubMed

Alsaeid, M; Alsaeid, K; Fatania, H R; Sharma, P N; Abd-Elsalam, R

1998-09-01

Elevated lipoprotein (a) [Lp(a)] is an independent risk factor for premature atherosclerosis and coronary heart disease, both of which are prevalent among Kuwaitis. Our objective was to measure serum lipids, including Lp(a), in Arab children and compare them with values reported for other ethnic groups. To that end, serum concentrations of Lp(a), total cholesterol [T-CHOL], high density lipoprotein [HDL], low density lipoprotein [LDL], and triglyceride [TG] were assessed in 103 Arab children. The mean and median Lp(a) were 140.4 mg/l and 95 mg/l, respectively. The Lp(a) frequency distribution was skewed to the right with the highest frequencies appearing at low levels. Serum Lp(a) correlated positively with T-CHOL and LDL but did not correlate with age, HDL and TG. Only nine children (8.7%) had serum Lp(a) levels associated with increased cardiovascular risk, namely > or = 300 mg/l.

The Land Processes Distributed Active Archive Center (LP DAAC)

USGS Publications Warehouse

Golon, Danielle K.

2016-10-03

The Land Processes Distributed Active Archive Center (LP DAAC) operates as a partnership with the U.S. Geological Survey and is 1 of 12 DAACs within the National Aeronautics and Space Administration (NASA) Earth Observing System Data and Information System (EOSDIS). The LP DAAC ingests, archives, processes, and distributes NASA Earth science remote sensing data. These data are provided to the public at no charge. Data distributed by the LP DAAC provide information about Earth’s surface from daily to yearly intervals and at 15 to 5,600 meter spatial resolution. Data provided by the LP DAAC can be used to study changes in agriculture, vegetation, ecosystems, elevation, and much more. The LP DAAC provides several ways to access, process, and interact with these data. In addition, the LP DAAC is actively archiving new datasets to provide users with a variety of data to study the Earth.

Feasibility demonstration of booster cross-over system for 3 1/2 inch SRB/MLP frangible nut system

NASA Technical Reports Server (NTRS)

1983-01-01

Recent testing of the SRB/MLP Frangible Nut System (SOS Part Number 114850-9/Boosters P/N 114848-3) at NASA indicated a need to reduce the function time between boosters (2) within a single frangible nut. These boosters are initiated separately by electrical impulse(s). Coupling the output of each detonator with an explosive cross-over would reduce the function time between boosters (independent of electrical impulse) while providing additional redundancy to the system. The objectives of this program were to: provide an explosive cross-over between boosters, reduce function time between boosters to less than one (1) millisecond within a given nut, reduce cost of boosters, be compatible with the existing frangible nut system, and meet requirements of USBI Spec's (nut 10SPC-0030, booster 10SPC-0031).

Development of a test rig for a helium twin-screw compressor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, B. M.; Hu, Z. J.; Zhang, P.

2014-01-29

A large helium cryogenic system is being developed for use in great science projects, such as the International Thermonuclear Experimental Reactor (ITER), Large Helical Device (LHD), and the Experimental Advanced Superconducting Tokamak (EAST). In this cryogenic system, a twin-screw compressor is a key component. Therefore, it is necessary to obtain the compressor performance. To obtain the performance characteristics, a test rig for the compressor has been built. All the important performance parameters, including adiabatic efficiency, volumetric efficiency, oil injection characteristic, and noise characteristic can be acquired with the rig when sensors are installed in the test system. With the testmore » performance, the helium twin-screw compressor can be evaluated. Using these results, the design of the compressor can be improved.« less

Unsteady Loss in the Stator Due to the Incoming Rotor Wake in a Highly-Loaded Transonic Compressor

NASA Technical Reports Server (NTRS)

Hah, Chunill

2015-01-01

The present paper reports an investigation of unsteady loss generation in the stator due to the incoming rotor wake in an advanced GE transonic compressor design with a high-fidelity numerical method. This advanced compressor with high reaction and high stage loading has been investigated both experimentally and analytically in the past. The measured efficiency in this advanced compressor is significantly lower than the design intention goal. The general understanding is that the current generation of compressor design analysis tools miss some important flow physics in this modern compressor design. To pinpoint the source of the efficiency miss, an advanced test with a detailed flow traverse was performed for the front one and a half stage at the NASA Glenn Research Center.

Refrigeration system having standing wave compressor

DOEpatents

Lucas, Timothy S.

1992-01-01

A compression-evaporation refrigeration system, wherein gaseous compression of the refrigerant is provided by a standing wave compressor. The standing wave compressor is modified so as to provide a separate subcooling system for the refrigerant, so that efficiency losses due to flashing are reduced. Subcooling occurs when heat exchange is provided between the refrigerant and a heat pumping surface, which is exposed to the standing acoustic wave within the standing wave compressor. A variable capacity and variable discharge pressure for the standing wave compressor is provided. A control circuit simultaneously varies the capacity and discharge pressure in response to changing operating conditions, thereby maintaining the minimum discharge pressure needed for condensation to occur at any time. Thus, the power consumption of the standing wave compressor is reduced and system efficiency is improved.

Compressor discharge bleed air circuit in gas turbine plants and related method

DOEpatents

Anand, Ashok Kumar; Berrahou, Philip Fadhel; Jandrisevits, Michael

2002-01-01

A gas turbine system that includes a compressor, a turbine component and a load, wherein fuel and compressor discharge bleed air are supplied to a combustor and gaseous products of combustion are introduced into the turbine component and subsequently exhausted to atmosphere. A compressor discharge bleed air circuit removes bleed air from the compressor and supplies one portion of the bleed air to the combustor and another portion of the compressor discharge bleed air to an exhaust stack of the turbine component in a single cycle system, or to a heat recovery steam generator in a combined cycle system. In both systems, the bleed air diverted from the combustor may be expanded in an air expander to reduce pressure upstream of the exhaust stack or heat recovery steam generator.

Compressor discharge bleed air circuit in gas turbine plants and related method

DOEpatents

Anand, Ashok Kumar [Niskayuna, NY; Berrahou, Philip Fadhel [Latham, NY; Jandrisevits, Michael [Clifton Park, NY

2003-04-08

A gas turbine system that includes a compressor, a turbine component and a load, wherein fuel and compressor discharge bleed air are supplied to a combustor and gaseous products of combustion are introduced into the turbine component and subsequently exhausted to atmosphere. A compressor discharge bleed air circuit removes bleed air from the compressor and supplies one portion of the bleed air to the combustor and another portion of the compressor discharge bleed air to an exhaust stack of the turbine component in a single cycle system, or to a heat recovery steam generator in a combined cycle system. In both systems, the bleed air diverted from the combustor may be expanded in an air expander to reduce pressure upstream of the exhaust stack or heat recovery steam generator.

76 FR 67017 - Praesidian Capital Opportunity Fund III, LP License No. 02/02-0647; Notice Seeking Exemption...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-28

... II, LP, Associate of Praesidian Capital Opportunity Fund III, LP, holds a debt investment and warrant... SMALL BUSINESS ADMINISTRATION Praesidian Capital Opportunity Fund III, LP License No. 02/02- 0647; Notice Seeking Exemption Under Section 312 of the Small Business Investment Act, Conflicts of Interest...

78 FR 25262 - TexStar Transmission, LP; TEAK Texana Transmission Company, LP; Notice of Filings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-30

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket Nos. PR13-16-002; PR13-17-002; Not Consolidated] TexStar Transmission, LP; TEAK Texana Transmission Company, LP; Notice of Filings Take notice that on April 23, 2013, the applicants listed above submitted an amendment to the December...

75 FR 8921 - Grant of Authority for Subzone Status; Brightpoint North America L.P. (Cell Phone Kitting and...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-26

... Status; Brightpoint North America L.P. (Cell Phone Kitting and Distribution) Indianapolis, IN Pursuant to... the cell phone kitting and distribution facilities of Brightpoint North America L.P., located in... cell phones at the facilities of Brightpoint North America L.P., located in Plainfield, Indiana...

Coupling analysis of non-circular-symmetric modes and design of orientation-insensitive few-mode fiber couplers

NASA Astrophysics Data System (ADS)

Li, Jiaxiong; Du, Jiangbing; Ma, Lin; Li, Ming-Jun; Jiang, Shoulin; Xu, Xiao; He, Zuyuan

2017-01-01

We study the coupling between two identical weakly-coupled few-mode fibers based on coupled-mode theory. The coupling behavior of non-circular-symmetric modes, such as LP11 and LP21, is investigated analytically and numerically. By carefully choosing the fiber core separation and coupler length, we can design orientation-insensitive fiber couplers for non-circular-symmetric modes at arbitrary coupling ratios. Based on the design method, we propose an orientation-insensitive two-mode fiber coupler at 850 nm working as a mode multiplexer/demultiplexer for two-mode transmission using standard single-mode fiber. Within the band from 845 to 855 nm, the insertion losses of LP01 and LP11 modes are less than 0.03 dB and 0.24 dB, respectively. When the two-mode fiber coupler is used as mode demultiplexer, the LP01/LP11 and LP11/LP01 extinction ratios in the separated branches are respectively above 12.6 dB and 21.2 dB. Our design method can be extended to two-mode communication or sensing systems at other wavelengths.

Characterization of a Novel Maltose-Forming α-Amylase from Lactobacillus plantarum subsp. plantarum ST-III.

PubMed

Jeon, Hye-Yeon; Kim, Na-Ri; Lee, Hye-Won; Choi, Hye-Jeong; Choung, Woo-Jae; Koo, Ye-Seul; Ko, Dam-Seul; Shim, Jae-Hoon

2016-03-23

A novel maltose (G2)-forming α-amylase from Lactobacillus plantarum subsp. plantarum ST-III was expressed in Escherichia coli and characterized. Analysis of conserved amino acid sequence alignments showed that L. plantarum maltose-producing α-amylase (LpMA) belongs to glycoside hydrolase family 13. The recombinant enzyme (LpMA) was a novel G2-producing α-amylase. The properties of purified LpMA were investigated following enzyme purification. LpMA exhibited optimal activity at 30 °C and pH 3.0. It produced only G2 from the hydrolysis of various substrates, including maltotriose (G3), maltopentaose (G5), maltosyl β-cyclodextrin (G2-β-CD), amylose, amylopectin, and starch. However, LpMA was unable to hydrolyze cyclodextrins. Reaction pattern analysis using 4-nitrophenyl-α-d-maltopentaoside (pNPG5) demonstrated that LpMA hydrolyzed pNPG5 from the nonreducing end, indicating that LpMA is an exotype α-amylase. Kinetic analysis revealed that LpMA had the highest catalytic efficiency (kcat/Km ratio) toward G2-β-CD. Compared with β-amylase, a well-known G2-producing enzyme, LpMA produced G2 more efficiently from liquefied corn starch due to its ability to hydrolyze G3.

Dynamic changes of the intraocular pressure and the pressure of cerebrospinal fluid in nonglaucomatous neurological patients.

PubMed

González-Camarena, Pedro Iván; San-Juan, Daniel; González-Olhovich, Irene; Rodríguez-Arévalo, David; Lozano-Elizondo, David; Trenado, Carlos; Anschel, David J

2017-03-01

To describe the dynamic changes of the intraocular pressure (IOP) and intracranial pressure (ICP) with normal or pathological values (intracranial hypertension) in nonglaucomatous neurological patients during lumbar punction (LP). Case-control study, prospective measurement of tonometry in both groups referred for LP. Intraocular pressure, ICP and translaminar pressure difference (TPD) were compared pre- and post-LP. Thirty-six patients (72 eyes) with mean age of 38.5 (16-64) years and BMI of 26.81 kg/m 2 were analysed. The initial mean ICP was 12.81 (± 6.6) mmHg. The mean TPD before and after the LP was 1.48 mmHg and 0.65 mmHg, respectively. The mean IOP of both eyes decreased to 0.8 mmHg post-LP in patients with pathological ICP (p = 0.0193) and normal ICP (p = 0.006). We found a statistically significant decrease of the IOP post-LP compared to the pre-LP in both groups, being higher in patients with pathological ICP. There were no significant differences of the IOP in patients with normal versus pathological ICP pre-LP/post-LP; neither was found a correlation between ICP and IOP. © 2016 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.

Heat shield manifold system for a midframe case of a gas turbine engine

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mayer, Clinton A.; Eng, Jesse; Schopf, Cheryl A.

A heat shield manifold system for an inner casing between a compressor and turbine assembly is disclosed. The heat shield manifold system protects the outer case from high temperature compressor discharge air, thereby enabling the outer case extending between a compressor and a turbine assembly to be formed from less expensive materials than otherwise would be required. In addition, the heat shield manifold system may be configured such that compressor bleed air is passed from the compressor into the heat shield manifold system without passing through a conventional flange to flange joint that is susceptible to leakage.

Experimental on-stream elimination of resonant whirl in a large centrifugal compressor

NASA Technical Reports Server (NTRS)

Bhat, G. I.; Eierman, R. G.

1984-01-01

Resonant whirl condition during operation of a multi-stage centrifugal compressor at higher than anticipated speeds and loads was reported. The condition was diagnosed by a large scale computerized Machinery Condition Monitoring System (MACMOS). This computerized system verified that the predominant subsynchronous whirl frequency locked in on the first resonant frequency of the compressor rotor and did not vary with compressor speed. Compressor stability calculations showed the rotor system had excessive hearing stiffness and inadequate effective damping. An optimum bearing design which was developed to minimize the unbalance response and to maximize the stability threshold is presented.

Thermodynamic properties of UF sub 6 measured with a ballistic piston compressor

NASA Technical Reports Server (NTRS)

Sterritt, D. E.; Lalos, G. T.; Schneider, R. T.

1973-01-01

From experiments performed with a ballistic piston compressor, certain thermodynamic properties of uranium hexafluoride were investigated. Difficulties presented by the nonideal processes encountered in ballistic compressors are discussed and a computer code BCCC (Ballistic Compressor Computer Code) is developed to analyze the experimental data. The BCCC unfolds the thermodynamic properties of uranium hexafluoride from the helium-uranium hexafluoride mixture used as the test gas in the ballistic compressor. The thermodynamic properties deduced include the specific heat at constant volume, the ratio of specific heats for UF6, and the viscous coupling constant of helium-uranium hexafluoride mixtures.

Rotating stall simulation for axial and centrifugal compressors

NASA Astrophysics Data System (ADS)

Halawa, Taher; Gadala, Mohamed S.

2017-05-01

This study presents a numerical simulation of the rotating stall phenomenon in axial and centrifugal compressors with detailed descriptions of stall precursors and its development with time. Results showed that the vaneless region of the centrifugal compressor is the most critical location affected by stall. It was found that the tip leakage flow and the back flow impingement are the main cause of the stall development at the impeller exit area for centrifugal compressors. The results of the axial compressor simulations indicated that the early separated flow combined with the tip leakage flow can block the impeller passages during stall.

Improved heat switch for gas sorption compressor

NASA Technical Reports Server (NTRS)

Chan, C. K.

1985-01-01

Thermal conductivities of the charcoal bed and the copper matrix for the gas adsorption compressor were measured by the concentric-cylinder method. The presence of the copper matrix in the charcoal bed enhanced the bed conductance by at least an order of magnitude. Thermal capacities of the adsorbent cell and the heat leaks to two compressor designs were measured by the transient method. The new gas adsorption compressor had a heat switch that could transfer eight times more heat than the previous one. The cycle time for the new prototype compressor is also improved by a factor of eight to within the minute range.

Advanced two-stage compressor program design of inlet stage

NASA Technical Reports Server (NTRS)

Bryce, C. A.; Paine, C. J.; Mccutcheon, A. R. S.; Tu, R. K.; Perrone, G. L.

1973-01-01

The aerodynamic design of an inlet stage for a two-stage, 10/1 pressure ratio, 2 lb/sec flow rate compressor is discussed. Initially a performance comparison was conducted for an axial, mixed flow and centrifugal second stage. A modified mixed flow configuration with tandem rotors and tandem stators was selected for the inlet stage. The term conical flow compressor was coined to describe a particular type of mixed flow compressor configuration which utilizes axial flow type blading and an increase in radius to increase the work input potential. Design details of the conical flow compressor are described.

Compatibility of booster seats and vehicles in the U.S. market.

PubMed

Bing, Julie A; Agnew, Amanda M; Bolte, John H

2018-05-19

The objective of this study was to analyze booster and rear vehicle seat dimensions to identify the most frequent compatibility problems. Measurements were collected from 40 high-back and backless boosters and 95 left rear and center rear row seating positions in 50 modern vehicles. Dimensions were compared for 3,800 booster/vehicle seat combinations. For validation and estimation of tolerance and correction factors, 72 booster installations were physically completed and compared with measurement-based compatibility predictions. Dimensions were also compared to the International Organization for Standardization (ISO) volumetric envelopes of forward-facing child restraints and boosters. Seat belt buckles in outboard positions accommodated the width of boosters better than center positions (success rates of 85.4 and 34.7%, respectively). Adequate head restraint clearance occurred in 71.9 to 77.2% of combinations, depending on the booster's head support setting. Booster recline angles aligned properly with vehicle seat cushion angles in 71.5% of combinations. In cases of poor angle alignment, booster angles were more obtuse than the vehicle seat angles 97.7% of the time. Head restraint interference exacerbated angle alignment issues. Data indicate success rates above 90% for boosters being fully supported by the length of the seat cushion and for adequate height clearance with the vehicle roofline. Comparison to ISO envelopes indicates that most boosters on the U.S. market are taller and angled more obtusely than ISO target envelopes. This study quantifies some of the common interferences between boosters and vehicles that may complicate booster usage. Data are useful for design and to prioritize specific problem areas.

The relationship between root hydraulics and scion vigour across Vitis rootstocks: what role do root aquaporins play?

PubMed Central

McElrone, A. J.

2012-01-01

Vitis vinifera scions are commonly grafted onto rootstocks of other grape species to influence scion vigour and provide resistance to soil-borne pests and abiotic stress; however, the mechanisms by which rootstocks affect scion physiology remain unknown. This study characterized the hydraulic physiology of Vitis rootstocks that vary in vigour classification by investigating aquaporin (VvPIP) gene expression, fine-root hydraulic conductivity (Lp r), % aquaporin contribution to Lp r, scion transpiration, and the size of root systems. Expression of several VvPIP genes was consistently greater in higher-vigour rootstocks under favourable growing conditions in a variety of media and in root tips compared to mature fine roots. Similar to VvPIP expression patterns, fine-root Lp r and % aquaporin contribution to Lp r determined under both osmotic (Lp r Osm) and hydrostatic (Lp r Hyd) pressure gradients were consistently greater in high-vigour rootstocks. Interestingly, the % aquaporin contribution was nearly identical for Lp r Osm and Lp r Hyd even though a hydrostatic gradient would induce a predominant flow across the apoplastic pathway. In common scion greenhouse experiments, leaf area-specific transpiration (E) and total leaf area increased with rootstock vigour and were positively correlated with fine-root Lp r. These results suggest that increased canopy water demands for scion grafted onto high-vigour rootstocks are matched by adjustments in root-system hydraulic conductivity through the combination of fine-root Lp r and increased root surface area. PMID:23136166

Dietary medium-chain triglycerides attenuate hepatic lipid deposition in growing rats with protein malnutrition.

PubMed

Kuwahata, Masashi; Kubota, Hiroyo; Amano, Saki; Yokoyama, Meiko; Shimamura, Yasuhiro; Ito, Shunsuke; Ogawa, Aki; Kobayashi, Yukiko; Miyamoto, Ken-ichi; Kido, Yasuhiro

2011-01-01

The objective of this study was to investigate the effects of dietary medium-chain triglycerides (MCT) on hepatic lipid accumulation in growing rats with protein malnutrition. Weaning rats were fed either a low-protein diet (3%, LP) or control protein diet (20%, CP), in combination with or without MCT. The four groups were as follows: CP-MCT, CP+MCT, LP-MCT, and LP+MCT. Rats in the CP-MCT, CP+MCT and LP+MCT groups were pair-fed their respective diets based on the amount of diet consumed by the LP-MCT group. Rats were fed each experimental diet for 30 d. Four weeks later, the respiratory quotient was higher in the LP-MCT group than those in the other groups during the fasting period. Hepatic triglyceride content increased in the LP groups compared with the CP groups. Hepatic triglyceride content in the LP+MCT group, however, was significantly decreased compared with that in the LP-MCT group. Levels of carnitine palmitoyltransferase (CPT) 1a mRNA and CPT2 mRNA were significantly decreased in the livers of the LP-MCT group, as compared with corresponding mRNA levels of the other groups. These results suggest that ingestion of a low-protein diet caused fatty liver in growing rats. However, when rats were fed the low-protein diet with MCT, hepatic triglyceride deposition was attenuated, and mRNA levels encoding CPT1a and CPT2 were preserved at the levels of rats fed control protein diets.

Variation of mucin adhesion, cell surface characteristics, and molecular mechanisms among Lactobacillus plantarum isolated from different habitats.

PubMed

Buntin, Nirunya; de Vos, Willem M; Hongpattarakere, Tipparat

2017-10-01

The adhesion ability to mucin varied greatly among 18 Lactobacillus plantarum isolates depending on their isolation habitats. Such ability remained at high level even though they were sequentially exposed to the gastrointestinal (GI) stresses. The majority of L. plantarum isolated from shrimp intestine and about half of food isolates exhibited adhesion ability (51.06-55.04%) about the same as the well-known adhesive L. plantarum 299v. Interestingly, five infant isolates of CIF17A2, CIF17A4, CIF17A5, CIF17AN2, and CIF17AN8 exhibited extremely high adhesion ranging from 62.69 to 72.06%. Such highly adhesive property correlating to distinctively high cell surface hydrophobicity was significantly weaken after pretreatment with LiCl and guanidine-HCl confirming the entailment of protein moiety. Regarding the draft genome information, all molecular structures of major cell wall-anchored proteins involved in the adhesion based on L. plantarum WCSF1, including lp_0964, lp_1643, lp_3114, lp_2486, lp_3127, and lp_3059 orthologues were detected in all isolates. Exceptionally, the gene-trait matching between yeast agglutination assay and the relevant mannose-specific adhesin (lp_1229) encoding gene confirmed the Msa absence in five infant isolates expressed distinctively high adhesion. Interestingly, the predicted flagellin encoding genes (fliC) firstly revealed in lp_1643, lp_2486, and lp_3114 orthologues may potentially contribute to such highly adhesive property of these isolates.

Discovery and in vivo evaluation of novel RGD-modified lipid-polymer hybrid nanoparticles for targeted drug delivery.

PubMed

Zhao, Yinbo; Lin, Dayong; Wu, Fengbo; Guo, Li; He, Gu; Ouyang, Liang; Song, Xiangrong; Huang, Wei; Li, Xiang

2014-09-29

In the current study, the lipid-shell and polymer-core hybrid nanoparticles (lpNPs) modified by Arg-Gly-Asp(RGD) peptide, loaded with curcumin (Cur), were developed by emulsification-solvent volatilization method. The RGD-modified hybrid nanoparticles (RGD-lpNPs) could overcome the poor water solubility of Cur to meet the requirement of intravenous administration and tumor active targeting. The obtained optimal RGD-lpNPs, composed of PLGA (poly(lactic-co-glycolic acid))-mPEG (methoxyl poly(ethylene- glycol)), RGD-polyethylene glycol (PEG)-cholesterol (Chol) copolymers and lipids, had good entrapment efficiency, submicron size and negatively neutral surface charge. The core-shell structure of RGD-lpNPs was verified by TEM. Cytotoxicity analysis demonstrated that the RGD-lpNPs encapsulated Cur retained potent anti-tumor effects. Flow cytometry analysis revealed the cellular uptake of Cur encapsulated in the RGD-lpNPs was increased for human umbilical vein endothelial cells (HUVEC). Furthermore, Cur loaded RGD-lpNPs were more effective in inhibiting tumor growth in a subcutaneous B16 melanoma tumor model. The results of immunofluorescent and immunohistochemical studies by Cur loaded RGD-lpNPs therapies indicated that more apoptotic cells, fewer microvessels, and fewer proliferation-positive cells were observed. In conclusion, RGD-lpNPs encapsulating Cur were developed with enhanced anti-tumor activity in melanoma, and Cur loaded RGD-lpNPs represent an excellent tumor targeted formulation of Cur which might be an attractive candidate for cancer therapy.

The Apo(a) gene is the major determinant of variation in plasma Lp(a) levels in African Americans.

PubMed Central

Mooser, V; Scheer, D; Marcovina, S M; Wang, J; Guerra, R; Cohen, J; Hobbs, H H

1997-01-01

The distributions of plasma lipoprotein(a), or Lp(a), levels differ significantly among ethnic groups. Individuals of African descent have a two- to threefold higher mean plasma level of Lp(a) than either Caucasians or Orientals. In Caucasians, variation in the plasma Lp(a) levels has been shown to be largely determined by sequence differences at the apo(a) locus, but little is known about either the genetic architecture of plasma Lp(a) levels in Africans or why they have higher levels of plasma Lp(a). In this paper we analyze the plasma Lp(a) levels of 257 sibling pairs from 49 independent African American families. The plasma Lp(a) levels were much more similar in the sibling pairs who inherited both apo(a) alleles identical by descent (IBD) (r = .85) than in those that shared one (r = .48) or no (r = .22) parental apo(a) alleles in common. On the basis of these findings, it was estimated that 78% of the variation in plasma Lp(a) levels in African Americans is attributable to polymorphism at either the apo(a) locus or sequences closely linked to it. Thus, the apo(a) locus is the major determinant of variation in plasma Lp(a) levels in African Americans, as well as in Caucasians. No molecular evidence was found for a common "high-expressing" apo(a) allele in the African Americans. We propose that the higher plasma levels of Lp(a) in Africans are likely due to a yet-to-be-identified trans-acting factor(s) that causes an increase in the rate of secretion of apo(a) or a decrease in its catabolism. PMID:9311746

Effects of bezafibrate and of 2 HMG-CoA reductase inhibitors on lipoprotein (a) level in hypercholesterolemic patients.

PubMed

Branchi, A; Rovellini, A; Fiorenza, A M; Sommariva, D

1995-06-01

Lp(a) level is relatively stable in each individual and is mainly under genetic control. Attempts made to lower Lp(a) with pharmacological means gave conflicting results. In order to further evaluate the effect of hypocholesterolemic drugs on Lp(a) level, 66 patients with primary hypercholesterolemia were selected. The vast majority of the patients had Lp(a) concentration at the low end of the range of distribution, 7 had undetectable Lp(a) levels and only 2 had Lp(a) higher than 30 mg/dl. No relationship was found between Lp(a) level and serum and lipoprotein lipids. In 12 patients serum cholesterol was well controlled by diet alone and the patients continued the diet for up to 8 months. The other patients were randomly subdivided into 3 groups of therapy. The first group received slow release bezafibrate 400 mg once a day, the second one pravastatin 20 mg once a day and the third one simvastatin 10-40 mg once a day. Drug therapy lasted for 8 months. At the end of the period, 22 of 29 patients treated with the 2 HMG-CoA reductase inhibitors had Lp(a) higher than baseline. The difference was statistically significant in both groups of patients. No significant change in Lp(a) was observed in diet and in bezafibrate group. Serum and LDL cholesterol significantly decreased in all the 3 drug groups. The increase in Lp(a) after the 2 HMG-CoA reductase was small enough to have negligible effects on cardiovascular risk, but raises the problem of the role of LDL receptor in the catabolism of Lp(a).

Effect of Lactobacillus plantarum LP-Onlly on gut flora and colitis in interleukin-10 knockout mice.

PubMed

Xia, Yang; Chen, Hong-Qi; Zhang, Min; Jiang, Yan-Qun; Hang, Xiao-Min; Qin, Huan-Long

2011-02-01

Probiotics are used in the therapy of inflammatory bowel disease. This study aimed to determine the effects of probiotic Lactobacillus plantarum LP-Onlly (LP) on gut flora and colitis in interleukin-10 knockout (IL-10(-/-) ) mice, a model of spontaneous colitis. IL-10(-/-) and wild-type mice were used at 8 weeks of age and LP by gavage was administered at a dose of 10(9) cells/day per mice for 4 weeks. Mice were maintained for another one week without LP treatment. The colonic tissues were collected for histological and ultrastructural analysis at death after 4 weeks treatment of LP, and the feces were collected at 1-week intervals throughout the experiment for the analysis of gut flora and LP using selective culture-based techniques. Compared with control mice, IL-10(-/-) mice developed a severe intestinal inflammation and tissue damage, and had an abnormal composition of gut microflora. LP administration attenuated colitis with the decreased inflammatory scoring and histological injury in the colon of IL-10(-/-) mice. In addition, LP administration increased the numbers of beneficial total bifidobacteria and lactobacilli, and decreased the numbers of potential pathogenic enterococci and Clostridium perfringens, although the decrease of coliforms was not significant after LP treatment in IL-10(-/-) mice. Oral administration of LP was effective in the treatment of colitis, with the direct modification of gut microflora in IL-10(-/-) mice. This probiotic strain could be used as a potential adjuvant in the therapy of inflammatory bowel disease, although further studies are required in human. © 2011 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd.

The role of indoleamine 2,3-dioxygenase in LP-BPM5 murine retroviral disease progression.

PubMed

O'Connor, Megan A; Green, William R

2013-05-17

Indoleamine 2,3-dioxygenase (IDO) is an immunomodulatory intracellular enzyme involved in tryptophan degradation. IDO is induced during cancer and microbial infections by cytokines, ligation of co-stimulatory molecules and/or activation of pattern recognition receptors, ultimately leading to modulation of the immune response. LP-BM5 murine retroviral infection induces murine AIDS (MAIDS), which is characterized by profound and broad immunosuppression of T- and B-cell responses. Our lab has previously described multiple mechanisms regulating the development of immunodeficiency of LP-BM5-induced disease, including Programmed Death 1 (PD-1), IL-10, and T-regulatory (Treg) cells. Immunosuppressive roles of IDO have been demonstrated in other retroviral models, suggesting a possible role for IDO during LP-BM5-induced retroviral disease progression and/or development of viral load. Mice deficient in IDO (B6.IDO-/-) and wildtype C57BL/6 (B6) mice were infected with LP-BM5 murine retrovirus. MAIDS and LP-BM5 viral load were assessed at termination. As expected, IDO was un-inducible in B6.IDO-/- during LP-BM5 infection. B6.IDO-/- mice infected with LP-BM5 retrovirus succumbed to MAIDS as indicated by splenomegaly, serum hyper IgG2a and IgM, decreased responsiveness to B- and T-cell mitogens, conversion of a proportion of CD4+ T cells from Thy1.2+ to Thy1.2-, and increased percentages of CD11b+Gr-1+ cells. LP-BM5 infected B6.IDO-/- mice also demonstrated the development of roughly equivalent disease kinetics as compared to infected B6 mice. Splenic viral loads of B6 and B6.IDO-/- mice were also equivalent after infection as measured by LP-BM5-specific Def Gag and Eco Gag viral mRNA, determined by qRT-PCR. Collectively, these results demonstrate IDO neither plays an essential role, nor is required, in LP-BM5-induced disease progression or LP-BM5 viral load.

Gestational Protein Restriction Impairs Insulin-Regulated Glucose Transport Mechanisms in Gastrocnemius Muscles of Adult Male Offspring

PubMed Central

Blesson, Chellakkan S.; Sathishkumar, Kunju; Chinnathambi, Vijayakumar

2014-01-01

Type II diabetes originates from various genetic and environmental factors. Recent studies showed that an adverse uterine environment such as that caused by a gestational low-protein (LP) diet can cause insulin resistance in adult offspring. The mechanism of insulin resistance induced by gestational protein restriction is not clearly understood. Our aim was to investigate the role of insulin signaling molecules in gastrocnemius muscles of gestational LP diet–exposed male offspring to understand their role in LP-induced insulin resistance. Pregnant Wistar rats were fed a control (20% protein) or isocaloric LP (6%) diet from gestational day 4 until delivery and a normal diet after weaning. Only male offspring were used in this study. Glucose and insulin responses were assessed after a glucose tolerance test. mRNA and protein levels of molecules involved in insulin signaling were assessed at 4 months in gastrocnemius muscles. Muscles were incubated ex vivo with insulin to evaluate insulin-induced phosphorylation of insulin receptor (IR), Insulin receptor substrate-1, Akt, and AS160. LP diet-fed rats gained less weight than controls during pregnancy. Male pups from LP diet–fed mothers were smaller but exhibited catch-up growth. Plasma glucose and insulin levels were elevated in LP offspring when subjected to a glucose tolerance test; however, fasting levels were comparable. LP offspring showed increased expression of IR and AS160 in gastrocnemius muscles. Ex vivo treatment of muscles with insulin showed increased phosphorylation of IR (Tyr972) in controls, but LP rats showed higher basal phosphorylation. Phosphorylation of Insulin receptor substrate-1 (Tyr608, Tyr895, Ser307, and Ser318) and AS160 (Thr642) were defective in LP offspring. Further, glucose transporter type 4 translocation in LP offspring was also impaired. A gestational LP diet leads to insulin resistance in adult offspring by a mechanism involving inefficient insulin-induced IR, Insulin receptor substrate-1, and AS160 phosphorylation and impaired glucose transporter type 4 translocation. PMID:24797633

The effects of gene disruption of Kre6-like proteins on the phenotype of β-glucan-producing Aureobasidium pullulans.

PubMed

Uchiyama, Hirofumi; Iwai, Atsushi; Dohra, Hideo; Ohnishi, Toshiyuki; Kato, Tatsuya; Park, Enoch Y

2018-05-01

Killer toxin resistant 6 (Kre6) and its paralog, suppressor of Kre null 1 (Skn1), are thought to be involved in the biosynthesis of cell wall β-(1 → 6)-D-glucan in baker's yeast, Saccharomyces cerevisiae. The Δkre6Δskn1 mutant of S. cerevisiae and other fungi shows severe growth defects due to the failure to synthesize normal cell walls. In this study, two homologs of Kre6, namely, K6LP1 (Kre6-like protein 1) and K6LP2 (Kre6-like protein 2), were identified in Aureobasidium pullulans M-2 by draft genome analysis. The Δk6lp1, Δk6lp2, and Δk6lp1Δk6lp2 mutants were generated in order to confirm the functions of the Kre6-like proteins in A. pullulans M-2. The cell morphologies of Δk6lp1 and Δk6lp1Δk6lp2 appeared to be different from those of wild type and Δk6lp2 in both their yeast and hyphal forms. The productivity of the extracellular polysaccharides, mainly composed of β-(1 → 3),(1 → 6)-D-glucan (β-glucan), of the mutants was 5.1-17.3% less than that of wild type, and the degree of branching in the extracellular β-glucan of mutants was 14.5-16.8% lower than that of wild type. This study showed that the gene disruption of Kre6-like proteins affected the cell morphology, the productivity of extracellular polysaccharides, and the structure of extracellular β-glucan, but it did not have a definite effect on the cell viability even in Δk6lp1Δk6lp2, unlike in the Δkre6Δskn1 of S. cerevisiae.

Mipomersen, an antisense oligonucleotide to apolipoprotein B-100, reduces lipoprotein(a) in various populations with hypercholesterolemia: Results of 4 Phase III Trials

PubMed Central

Santos, Raul D.; Raal, MD Frederick J.; Catapano, Alberico L.; Witztum, Joseph L; Steinhagen-Thiessen, Elisabeth; Tsimikas, Sotirios

2015-01-01

Objective Lp(a) is an independent, causal, genetic risk factor for cardiovascular disease and aortic stenosis. Current pharmacologic lipid-lowering therapies do not optimally lower Lp(a), particularly in patients with familial hypercholesterolemia (FH). Approach and Results In four Phase III trials, 382 patients on maximally tolerated lipid-lowering therapy were randomized 2:1 to weekly subcutaneous mipomersen 200 mg (n=256) or placebo (n=126) for 26 weeks. Populations included homozygous FH (HoFH), heterozygous FH (HeFH) with concomitant coronary artery disease (CAD), severe hypercholesterolemia (HC), and HC at high risk for CAD. Lp(a) was measured eight times between baseline and week 28 inclusive. Of the 382 patients, 57% and 44% had baseline Lp(a) levels >30 mg/dL and >50 mg/dL, respectively. In the pooled analysis, the mean percent decrease (median, interquartile range, IQR) in Lp(a) at 28 weeks was significantly greater in the mipomersen group compared with placebo (-26.4 (-42.8, 5.4) vs. -0.0 (10.7, 15.3), p<0.001). In the mipomersen group in patients with Lp(a) levels >30 mg/dL or >50 mg/dL, attainment of Lp(a) values ≤30 mg/dL or ≤50 mg/dL was most frequent in HoFH and severe HC patients. In the combined groups, modest correlations were present between percent change in apoB and Lp(a) (r=0.43, p<0.001) and LDL-C and Lp(a) (r=0.36, p<0.001) plasma levels. Conclusions Mipomersen consistently and effectively reduced Lp(a) levels in patients with a variety of lipid abnormalities and cardiovascular risk. Modest correlations were present between apoB and Lp(a) lowering but the mechanistic relevance mediating Lp(a) reduction is currently unknown. PMID:25614280

47 CFR 74.1203 - Interference.

Code of Federal Regulations, 2014 CFR

2014-10-01

... FM Broadcast Booster Stations § 74.1203 Interference. (a) An authorized FM translator or booster..., TV booster, FM translator or FM booster station; or (3) The direct reception by the public of the off... FM booster stations. Interference will be considered to occur whenever reception of a regularly used...

47 CFR 74.1203 - Interference.

Code of Federal Regulations, 2013 CFR

2013-10-01

... FM Broadcast Booster Stations § 74.1203 Interference. (a) An authorized FM translator or booster..., TV booster, FM translator or FM booster station; or (3) The direct reception by the public of the off... FM booster stations. Interference will be considered to occur whenever reception of a regularly used...

47 CFR 74.1203 - Interference.

Code of Federal Regulations, 2011 CFR

2011-10-01

... FM Broadcast Booster Stations § 74.1203 Interference. (a) An authorized FM translator or booster..., TV booster, FM translator or FM booster station; or (3) The direct reception by the public of the off... FM booster stations. Interference will be considered to occur whenever reception of a regularly used...

47 CFR 74.1203 - Interference.

Code of Federal Regulations, 2012 CFR

2012-10-01

... FM Broadcast Booster Stations § 74.1203 Interference. (a) An authorized FM translator or booster..., TV booster, FM translator or FM booster station; or (3) The direct reception by the public of the off... FM booster stations. Interference will be considered to occur whenever reception of a regularly used...

Flow Characterization and Dynamic Analysis of a Radial Compressor with Passive Method of Surge Control

NASA Astrophysics Data System (ADS)

Guillou, Erwann

Due to recent emission regulations, the use of turbochargers for force induction of internal combustion engines has increased. Actually, the trend in diesel engines is to downsize the engine by use of turbochargers that operate at higher pressure ratio. Unfortunately, increasing the rotational speed tends to reduce the turbocharger radial compressor range of operation which is limited at low mass flow rate by the occurrence of surge. In order to extent the operability of turbochargers, compressor housings can be equipped with a passive surge control device also known as ported shroud. This specific casing treatment has been demonstrated to enhance surge margin with minor negative impact on the compressor efficiency. However, the actual working mechanisms of the bypass system remain not well understood. In order to optimize the design of the ported shroud, it is then crucial to identify the dynamic flow changes induced by the implementation of the device to control instabilities. Experimental methods were used to assess the development of instabilities from stable, stall and eventually surge regimes of a ported shroud centrifugal compressor. Systematic comparison was conducted with the same compressor design without ported shroud. Hence, the full pressure dynamic survey of both compressors' performance characteristics converged toward two different and probably interrelated driving mechanisms to the development and/or propagation of unsteadiness within each compressor. One related the pressure disturbances at the compressor inlet, and notably the more apparent development of perturbations in the non-ported compressor impeller, whereas the other was attributed to the pressure distortions induced by the presence of the tongue in the asymmetric design of the compressor volute. Specific points of operation were selected to carry out planar flow measurements. At normal working, both standard and stereoscopic particle imaging velocimetry (PIV) measurements were performed to calculate the instantaneous and mean velocity fields at the inlet of the compressor. At incipient and full surge, phase-locked PIV measurements were added. In this work, satisfying characterization of the compressor inlet flow instabilities was obtained at different operational speeds. Combining transient pressure data and PIV measurements, the time evolution of the complex flow patterns occurring at surge was reconstructed and a better insight into the bypass mechanisms was achieved.

Genomic organization, sequence characterization and expression analysis of Tenebrio molitor apolipophorin-III in response to an intracellular pathogen, Listeria monocytogenes.

PubMed

Noh, Ju Young; Patnaik, Bharat Bhusan; Tindwa, Hamisi; Seo, Gi Won; Kim, Dong Hyun; Patnaik, Hongray Howrelia; Jo, Yong Hun; Lee, Yong Seok; Lee, Bok Luel; Kim, Nam Jung; Han, Yeon Soo

2014-01-25

Apolipophorin III (apoLp-III) is a well-known hemolymph protein having a functional role in lipid transport and immune response of insects. We cloned full-length cDNA encoding putative apoLp-III from larvae of the coleopteran beetle, Tenebrio molitor (TmapoLp-III), by identification of clones corresponding to the partial sequence of TmapoLp-III, subsequently followed with full length sequencing by a clone-by-clone primer walking method. The complete cDNA consists of 890 nucleotides, including an ORF encoding 196 amino acid residues. Excluding a putative signal peptide of the first 20 amino acid residues, the 176-residue mature apoLp-III has a calculated molecular mass of 19,146Da. Genomic sequence analysis with respect to its cDNA showed that TmapoLp-III was organized into four exons interrupted by three introns. Several immune-related transcription factor binding sites were discovered in the putative 5'-flanking region. BLAST and phylogenetic analyses reveal that TmapoLp-III has high sequence identity (88%) with Tribolium castaneum apoLp-III but shares little sequence homologies (<26%) with other apoLp-IIIs. Homology modeling of Tm apoLp-III shows a bundle of five amphipathic alpha helices, including a short helix 3'. The 'helix-short helix-helix' motif was predicted to be implicated in lipid binding interactions, through reversible conformational changes and accommodating the hydrophobic residues to the exterior for stability. Highest level of TmapoLp-III mRNA was detected at late pupal stages, albeit it is expressed in the larval and adult stages at lower levels. The tissue specific expression of the transcripts showed significantly higher numbers in larval fat body and adult integument. In addition, TmapoLp-III mRNA was found to be highly upregulated in late stages of L. monocytogenes or E. coli challenge. These results indicate that TmapoLp-III may play an important role in innate immune responses against bacterial pathogens in T. molitor. Copyright © 2013 Elsevier B.V. All rights reserved.

PLA2G7 genotype, Lp-PLA2 activity and coronary heart disease risk in 10,494 cases and 15,624 controls of European ancestry

PubMed Central

Casas, Juan P.; Ninio, Ewa; Panayiotou, Andrie; Palmen, Jutta; Cooper, Jackie A; Ricketts, Sally L; Sofat, Reecha; Nicolaides, Andrew N; Corsetti, James P; Fowkes, F Gerry R; Tzoulaki, Ioanna; Kumari, Meena; Brunner, Eric J; Kivimaki, Mika; Marmot, Michael G; Hoffmann, Michael M; Winkler, Karl; März, Winfred; Ye, Shu; Stirnadel, Heide A; MBBChir, Kay-Tee Khaw; Humphries, Steve E; Sandhu, Manjinder S; Hingorani, Aroon D; Talmud, Philippa J

2012-01-01

Background Higher Lp-PLA2 activity is associated with increased risk of coronary heart disease (CHD), making Lp-PLA2 a potential therapeutic target. PLA2G7 variants associated with Lp-PLA2 activity could evaluate whether this relationship is causal. Methods and Results A meta-analysis including a total of 12 studies (5 prospective, 4 case-control, 1 case-only and 2 cross-sectional, n=26,118) was undertaken to examine the association of: (i) LpPLA2 activity vs. cardiovascular biomarkers and risk factors and CHD events (two prospective studies; n=4884); ii) PLA2G7 SNPs and Lp-PLA2 activity (3 prospective, 2 case-control, 2 cross-sectional studies; up to n=6094); and iii) PLA2G7 SNPs and angiographic coronary artery disease (2 case-control, 1 case-only study; n=4971 cases) and CHD events (5 prospective, 2 case-control studies; n=5523). Lp-PLA2 activity correlated with several CHD risk markers. Hazard ratio for CHD events top vs. bottom quartile of Lp-PLA2 activity was 1.61 (95%CI: 1.31, 1.99) and 1.17 (95%CI: 0.91, 1.51) after adjustment for baseline traits. Of seven SNPs, rs1051931 (A379V) showed the strongest association with Lp-PLA2 activity, VV subjects having 7.2% higher activity than AAs. Genotype was not associated with risk markers, angiographic coronary disease (OR 1.03 (95%CI 0.80, 1.32), or CHD events (OR 0.98 (95%CI 0.82, 1.17). Conclusions Unlike Lp-PLA2 activity, PLA2G7 variants associated with modest effects on Lp-PLA2 activity were not associated with cardiovascular risk markers, coronary atheroma or CHD. Larger association studies, identification of SNPs with larger effects, or randomised trials of specific Lp-PLA2 inhibitors are needed to confirm/refute a contributory role for Lp-PLA2 in CHD. PMID:20479152

Simvastatin but not bezafibrate decreases plasma lipoprotein-associated phospholipase A₂ mass in type 2 diabetes mellitus: relevance of high sensitive C-reactive protein, lipoprotein profile and low-density lipoprotein (LDL) electronegativity.

PubMed

Constantinides, Alexander; de Vries, Rindert; van Leeuwen, Jeroen J J; Gautier, Thomas; van Pelt, L Joost; Tselepis, Alexandros D; Lagrost, Laurent; Dullaart, Robin P F

2012-10-01

Plasma lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) levels predict incident cardiovascular disease, impacting Lp-PLA(2) as an emerging therapeutic target. We determined Lp-PLA(2) responses to statin and fibrate administration in type 2 diabetes mellitus, and assessed relationships of changes in Lp-PLA(2) with subclinical inflammation and lipoprotein characteristics. A placebo-controlled cross-over study (three 8-week treatment periods with simvastatin (40 mg daily), bezafibrate (400mg daily) and their combination) was carried out in 14 male type 2 diabetic patients. Plasma Lp-PLA(2) mass was measured by turbidimetric immunoassay. Plasma Lp-PLA(2) decreased (-21 ± 4%) in response to simvastatin (p<0.05 from baseline and placebo), but was unaffected by bezafibrate (1 ± 5%). The drop in Lp-PLA(2) during combined treatment (-17 ± 3%, p<0.05) was similar compared to that during simvastatin alone. The Lp-PLA(2) changes during the 3 active lipid lowering treatment periods were related positively to baseline levels of high sensitive C-reactive protein, non-HDL cholesterol, triglycerides, the total cholesterol/HDL cholesterol ratio and less LDL electronegativity (p<0.02 to p<0.01), and inversely to baseline Lp-PLA(2) (p<0.01). LpPLA(2) responses correlated inversely with changes in non-HDL cholesterol, triglycerides and the total cholesterol/HDL cholesterol ratio during treatment (p<0.05 to p<0.02). In type 2 diabetes mellitus, plasma Lp-PLA(2) is likely to be lowered by statin treatment only. Enhanced subclinical inflammation and more severe dyslipidemia may predict diminished LpPLA(2) responses during lipid lowering treatment, which in turn appear to be quantitatively dissociated from decreases in apolipoprotein B lipoproteins. Conventional lipid lowering treatment may be insufficient for optimal LpPLA(2) lowering in diabetes mellitus. Copyright © 2012 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.

Ultradeformable Archaeosomes for Needle Free Nanovaccination with Leishmania braziliensis Antigens.

PubMed

Higa, Leticia H; Arnal, Laura; Vermeulen, Mónica; Perez, Ana Paula; Schilrreff, Priscila; Mundiña-Weilenmann, Cecilia; Yantorno, Osvaldo; Vela, María Elena; Morilla, María José; Romero, Eder Lilia

2016-01-01

Total antigens from Leishmania braziliensis promastigotes, solubilized with sodium cholate (dsLp), were formulated within ultradeformable nanovesicles (dsLp-ultradeformable archaeosomes, (dsLp-UDA), and dsLp-ultradeformable liposomes (dsLp-UDL)) and topically administered to Balb/c mice. Ultradeformable nanovesicles can penetrate the intact stratum corneum up to the viable epidermis, with no aid of classical permeation enhancers that can damage the barrier function of the skin. Briefly, 100 nm unilamellar dsLp-UDA (soybean phosphatidylcholine: Halorubrum tebenquichense total polar lipids (TPL): sodium cholate, 3:3:1 w:w) of -31.45 mV Z potential, containing 4.84 ± 0.53% w/w protein/lipid dsLp, 235 KPa Young modulus were prepared. In vitro, dsLp-UDA was extensively taken up by J774A1 and bone marrow derive cells, and the only that induced an immediate secretion of IL-6, IL-12p40 and TNF-α, followed by IL-1β, by J774A1 cells. Such extensive uptake is a key feature of UDA ascribed to the highly negatively charged archaeolipids of the TPL, which are recognized by a receptor specialized in uptake and not involved in downstream signaling. Despite dsLp alone was also immunostimulatory on J774A1 cells, applied twice a week on consecutive days along 7 weeks on Balb/c mice, it raised no measurable response unless associated to UDL or UDA. The highest systemic response, IgGa2 mediated, 1 log lower than im dsLp Al2O3, was elicited by dsLp-UDA. Such findings suggest that in vivo, UDL and UDA acted as penetration enhancers for dsLp, but only dsLp-UDA, owed to its pronounced uptake by APC, succeeded as topical adjuvants. The actual TPL composition, fully made of sn2,3 ether linked saturated archaeolipids, gives the UDA bilayer resistance against chemical, physical and enzymatic attacks that destroy ordinary phospholipids bilayers. Together, these properties make UDA a promising platform for topical drug targeted delivery and vaccination, that may be of help for countries with a deficient healthcare system.

Antisense oligonucleotide directed to human apolipoprotein B-100 reduces lipoprotein(a) levels and oxidized phospholipids on human apolipoprotein B-100 particles in lipoprotein(a) transgenic mice.

PubMed

Merki, Esther; Graham, Mark J; Mullick, Adam E; Miller, Elizabeth R; Crooke, Rosanne M; Pitas, Robert E; Witztum, Joseph L; Tsimikas, Sotirios

2008-08-12

Lipoprotein (a) [Lp(a)] is a genetic cardiovascular risk factor that preferentially binds oxidized phospholipids (OxPL) in plasma. There is a lack of therapeutic agents that reduce plasma Lp(a) levels. Transgenic mice overexpressing human apolipoprotein B-100 (h-apoB-100 [h-apoB mice]) or h-apoB-100 plus human apo(a) to generate genuine Lp(a) particles [Lp(a) mice] were treated with the antisense oligonucleotide mipomersen directed to h-apoB-100 mRNA or control antisense oligonucleotide for 11 weeks by intraperitoneal injection. Mice were then followed up for an additional 10 weeks off therapy. Lp(a) levels [apo(a) bound to apoB-100] and apo(a) levels ["free" apo(a) plus apo(a) bound to apoB-100] were measured by chemiluminescent enzyme-linked immunoassay and commercial assays, respectively. The content of OxPL on h-apoB-100 particles (OxPL/h-apoB) was measured by capturing h-apoB-100 in microtiter wells and detecting OxPL by antibody E06. As expected, mipomersen significantly reduced plasma h-apoB-100 levels in both groups of mice. In Lp(a) mice, mipomersen significantly reduced Lp(a) levels by approximately 75% compared with baseline (P<0.0001) but had no effect on apo(a) levels or hepatic apo(a) mRNA expression. OxPL/h-apoB levels were much higher at baseline in Lp(a) mice compared with h-ApoB mice (P<0.0001) but decreased in a time-dependent fashion with mipomersen. There was no effect of the control antisense oligonucleotide on lipoprotein levels or oxidative parameters. Mipomersen significantly reduced Lp(a) and OxPL/apoB levels in Lp(a) mice. The present study demonstrates that h-apoB-100 is a limiting factor in Lp(a) particle synthesis in this Lp(a) transgenic model. If applicable to humans, mipomersen may represent a novel therapeutic approach to reducing Lp(a) levels and their associated OxPL.

Metabolic and anthropometric determinants of serum Lp(a) concentrations and Apo(a) polymorphism in a healthy Arab population.

PubMed

Akanji, A O; al-Shayji, I A; Kumar, P

1999-08-01

Blood lipoprotein(a) Lp(a) concentrations are an important risk factor for atherosclerosis. The basis for this atherogenic property of Lp(a) and the factors that influence its cross-population levels, however, remain poorly understood. To investigate the relationship between serum Lp(a) and metabolic and anthropometric parameters in a healthy Kuwaiti population. Cross-sectional study. 177 (72 male, 105 female) randomly recruited healthy Kuwait Arabs aged 17-60 y Metabolic parameters in serum: Lp(a), apo(a) phenotypes, lipids and lipoproteins, glucose and urate. Anthropometric parameters: body mass index (BMI) and waist:hip-ratio (WHR). The distribution of Lp(a) concentrations was positively skewed (median 153 mg/l, range 0-1086). Women had higher concentrations-(194, 0-1086) than men (117, 0-779), P = 0.069. Lp(a) and insulin concentrations were significantly higher when the men and women were obese. In all subjects, there were significant correlations between Lp(a) and BMI (r = 0.23), total cholesterol (TC) (r = 0.17) and LDL (r = 0.20). Lp(a) correlated only with glucose in men (r = 0.28). In women it correlated with age (r = 0.20), BMI (r = 0.30), BP (r = 0.20), TC (r = 0.20) and LDL (r = 0.26). Multivariate analyses confirmed BMI and low-density lipoprotein (LDL) as the significant determinants of serum Lp(a). On apo (a) phenotyping, 114 (67%), 51 (30%) and 6 (4%) had single, double and null phenotypes respectively. The isoforms and their corresponding kringle IV repeat numbers were: F (14 repeats in 3%, mean Lp(a) 497 mg/l); S1 (19 repeats in 14%, mean 245 mg/l); S2 (23 repeats in 16%, mean 264 mg/l); S3 (27 repeats in 35%, mean 236 mg/l); and S4 (35 repeats in 28%, mean 235 mg/l). The results from the Kuwaiti population studied suggest that: (1) serum Lp(a) concentrations and distribution are similar to the pattern in Caucasians and Asians but not African-Americans or Africans; (2) serum Lp(a) is variably influenced by BMI and LDL--the impact of either factor differs between the sexes; (3) there is a high frequency of the single-banded phenotype; (4) contrary to reports in some Caucasian and Asian populations, there is no simple relationship between kringle IV repeat numbers and plasma Lp(a) concentrations.

Liposomal 64Cu-PET Imaging of Anti-VEGF Drug Effects on Liposomal Delivery to Colon Cancer Xenografts.

PubMed

Blocker, Stephanie J; Douglas, Kirk A; Polin, Lisa Anne; Lee, Helen; Hendriks, Bart S; Lalo, Enxhi; Chen, Wei; Shields, Anthony F

2017-01-01

Liposomes (LP) deliver drug to tumors due to enhanced permeability and retention (EPR). LP were labeled with 64 Cu for positron emission tomography (PET) to image tumor localization. Bevacizumab (bev), a VEGF targeted antibody, may modify LP delivery by altering tumor EPR and this change can also be imaged. Objective : Assess the utility of 64 Cu-labeled LP for PET in measuring altered LP delivery early after treatment with bev. Methods: HT-29 human colorectal adenocarcinoma tumors were grown subcutaneously in SCID mice. Empty LP MM-DX-929 (Merrimack Pharmaceuticals, Inc. Cambridge, MA) were labeled with 64 CuCl 2 chelated with 4-DEAP-ATSC. Tumor-bearing mice received ~200-300 μCi of 64 Cu-MM-DX-929 and imaged with microPET. All mice were scanned before and after the treatment period, in which half of the mice received bev for one week. Scans were compared for changes in LP accumulation during this time. Initially, tissues were collected after the second PET for biodistribution measurements and histological analysis. Subsequent groups were divided for further treatment. Tumor growth following bev treatment, with or without LP-I, was assessed compared to untreated controls. Results : PET scans of untreated mice showed increased uptake of 64 Cu-MM-DX-929, with a mean change in tumor SUV max of 43.9%±6.6% (n=10) after 7 days. Conversely, images of treated mice showed that liposome delivery did not increase, with changes in SUV max of 7.6%±4.8% (n=12). Changes in tumor SUV max were significantly different between both groups (p=0.0003). Histology of tumor tissues indicated that short-term bev was able to alter vessel size. Therapeutically, while bev monotherapy, LP-I monotherapy, and treatment with bev followed by LP-I all slowed HT-29 tumor growth compared to controls, combination provided no therapeutic benefit. Conclusions: PET with tracer LP 64 Cu-MM-DX-929 can detect significant differences in LP delivery to colon tumors treated with bev when compared to untreated controls. Imaging with 64 Cu-MM-DX-929 is sensitive enough to measure drug-induced changes in LP localization which can have an effect on outcomes of treatment with LP.

Lubrication free centrifugal compressor. Technical report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gottschlich, J.M.; Scaringe, R.P.; Gui, F.

1994-04-22

This paper describes an effort to demonstrate the benefits of an innovative, lightweight, lubrication free centrifugal compressor that allows the use of environmentally sale alternate refrigerants with improved system efficiencies over current state-of-the-art technology. This effort couples the recently developed 3-D high efficiency centrifugal compressor and fabrication technologies with magnetic bearing technology and will then prove the performance, life and reliability of the compressor.

Transonic Fan/Compressor Rotor Design Study. Volume 4

DTIC Science & Technology

1982-02-01

amd Identify by block number) Fan Aircraft Engines Compressor Blade Thickness Rotor Camber Distribution Aerodesign Throat Margin Aerodynamics 20...COMPRESSOR ROTOR DESIGN STUDY Volume IV D.E. Parker and M.R. Simonson General Electric Company Aircraft Engine Business Group Advanced Technology...Compressor Research Group Chief, Technology Branch FOR THE COMMANDER H. IVAN BUS Director, Turbine Engine Division If your address has changed, if you

47 CFR 74.1233 - Processing FM translator and booster station applications.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 47 Telecommunication 4 2014-10-01 2014-10-01 false Processing FM translator and booster station... SERVICES FM Broadcast Translator Stations and FM Broadcast Booster Stations § 74.1233 Processing FM translator and booster station applications. (a) Applications for FM translator and booster stations are...

47 CFR 74.1233 - Processing FM translator and booster station applications.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 47 Telecommunication 4 2012-10-01 2012-10-01 false Processing FM translator and booster station... SERVICES FM Broadcast Translator Stations and FM Broadcast Booster Stations § 74.1233 Processing FM translator and booster station applications. (a) Applications for FM translator and booster stations are...

47 CFR 74.733 - UHF translator signal boosters.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 47 Telecommunication 4 2014-10-01 2014-10-01 false UHF translator signal boosters. 74.733 Section... Translator, and TV Booster Stations § 74.733 UHF translator signal boosters. (a) The licensee of a UHF television broadcast translator station may be authorized to operate one or more signal boosters for the...

47 CFR 74.1233 - Processing FM translator and booster station applications.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 47 Telecommunication 4 2011-10-01 2011-10-01 false Processing FM translator and booster station... SERVICES FM Broadcast Translator Stations and FM Broadcast Booster Stations § 74.1233 Processing FM translator and booster station applications. (a) Applications for FM translator and booster stations are...

47 CFR 74.733 - UHF translator signal boosters.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 47 Telecommunication 4 2013-10-01 2013-10-01 false UHF translator signal boosters. 74.733 Section... Translator, and TV Booster Stations § 74.733 UHF translator signal boosters. (a) The licensee of a UHF television broadcast translator station may be authorized to operate one or more signal boosters for the...

47 CFR 74.1233 - Processing FM translator and booster station applications.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 47 Telecommunication 4 2013-10-01 2013-10-01 false Processing FM translator and booster station... SERVICES FM Broadcast Translator Stations and FM Broadcast Booster Stations § 74.1233 Processing FM translator and booster station applications. (a) Applications for FM translator and booster stations are...

47 CFR 74.1233 - Processing FM translator and booster station applications.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 4 2010-10-01 2010-10-01 false Processing FM translator and booster station... SERVICES FM Broadcast Translator Stations and FM Broadcast Booster Stations § 74.1233 Processing FM translator and booster station applications. (a) Applications for FM translator and booster stations are...

47 CFR 74.733 - UHF translator signal boosters.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 4 2010-10-01 2010-10-01 false UHF translator signal boosters. 74.733 Section... Translator, and TV Booster Stations § 74.733 UHF translator signal boosters. (a) The licensee of a UHF television broadcast translator station may be authorized to operate one or more signal boosters for the...

Space shuttle with common fuel tank for liquid rocket booster and main engines (supertanker space shuttle)

NASA Technical Reports Server (NTRS)

Thorpe, Douglas G.

1991-01-01

An operation and schedule enhancement is shown that replaces the four-body cluster (Space Shuttle Orbiter (SSO), external tank, and two solid rocket boosters) with a simpler two-body cluster (SSO and liquid rocket booster/external tank). At staging velocity, the booster unit (liquid-fueled booster engines and vehicle support structure) is jettisoned while the remaining SSO and supertank continues on to orbit. The simpler two-bodied cluster reduces the processing and stack time until SSO mate from 57 days (for the solid rocket booster) to 20 days (for the liquid rocket booster). The areas in which liquid booster systems are superior to solid rocket boosters are discussed. Alternative and future generation vehicles are reviewed to reveal greater performance and operations enhancements with more modifications to the current methods of propulsion design philosophy, e.g., combined cycle engines, and concentric propellant tanks.

Initiation Capacity of a Specially Shaped Booster Pellet and Numerical Simulation of Its Initiation Process

NASA Astrophysics Data System (ADS)

Hu, Li-Shuang; Hu, Shuang-Qi; Cao, Xiong; Zhang, Jian-Ren

2014-01-01

The insensitive main charge explosive is creating new requirements for the booster pellet of detonation trains. The traditional cylindrical booster pellet has insufficient energy output to reliably initiate the insensitive main charge explosive. In this research, a concave spherical booster pellet was designed. The initiation capacity of the concave spherical booster pellet was studied using varied composition and axial steel dent methods. The initiation process of the concave spherical booster pellet was also simulated by ANSYS/LS-DYNA. The results showed that using a concave spherical booster allows a 42% reduction in the amount of explosive needed to match the initiation capacity of a conventional cylindrical booster of the same dimensions. With the other parameters kept constant, the initiation capacity of the concave spherical booster pellet increases with decreased cone angle and concave radius. The numerical simulation results are in good agreement with the experimental data.

Tailored interventions for screening mammography among a sample of initially non-adherent women: when is a booster dose important?

PubMed

Skinner, Celette Sugg; Kobrin, Sarah C; Monahan, Patrick O; Daggy, Joanne; Menon, Usha; Todora, Helen Smith; Champion, Victoria L

2007-01-01

To assess added value of a booster dose of a tailored mammography intervention. Participants, non-adherent at baseline, were randomly assigned to usual care or one of three tailored interventions. Intervention group members (n=657) were further randomly assigned to receive/not receive a booster intervention dose. Electronic record mammography data were collected following initial intervention and at 6 and 15 months post-booster. Booster had no effect among women not screened after first intervention dose (n=337). Among women screened after initial dose (n=320), booster predicted re-screening at 6 but not 15 months. A boosterxrace interaction showed a booster effect at 6 months for African Americans (OR=4.66, p=.0005) but not Caucasians (OR=0.74, p=.44). Findings suggest if a first-dose intervention does not facilitate screening, neither will a booster dose. However, among women for whom a first dose is effective, boosters can facilitate timely repeat adherence, especially among African Americans. At 6 months booster recipients were less likely to be off-schedule but, by 15 months, the groups were similar. Boosters may effect when, but not whether, women continue screening.

Engineering report: Oxygen boost compressor study

NASA Technical Reports Server (NTRS)

Tera, L. S.

1974-01-01

An oxygen boost compressor is described which supports a self-contained life support system. A preliminary analysis of the compressor is presented along with performance test results, and recommendations for follow-on efforts.

75 FR 64306 - Shell Energy North America (US), LP; Notice of Institution of Proceeding and Refund Effective Date

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-19

...] Shell Energy North America (US), LP; Notice of Institution of Proceeding and Refund Effective Date...), concerning the justness and reasonableness of Shell Energy North America (US), LP's market- based rate authority in the Central and Southwest balancing authority area. Shell Energy North America (US), LP, 133...

76 FR 53440 - Freeport LNG Development, LP; Freeport LNG Expansion, LP; FLNG Liquefaction LLC; Notice of Intent...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-26

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PF11-2-000] Freeport LNG Development, LP; Freeport LNG Expansion, LP; FLNG Liquefaction LLC; Notice of Intent To Prepare an Environmental Assessment for the Planned Liquefaction Project, Request for Comments on Environmental Issues, and Notice of Public Scoping Meeting The...

77 FR 74179 - TexStar Transmission, LP; TEAK Texana Transmission Company, LP; Notice of Baseline Filings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-13

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PR13-16-000; Docket No. PR13-17-000; Not Consolidated] TexStar Transmission, LP; TEAK Texana Transmission Company, LP; Notice of Baseline Filings Take notice that on December 6, 2012, the applicants listed above submitted a baseline...

78 FR 22872 - TexStar Transmission, LP; TEAK Texana Transmission Company, LP; Notice of Filings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-17

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PR13-16-001; Docket No. PR13-17-001; Not Consolidated] TexStar Transmission, LP; TEAK Texana Transmission Company, LP; Notice of Filings Take notice that on April 5, 2013, the applicants listed above submitted an amendment to the...

Analysis of inlet flow distortion and turbulence effects on compressor stability

NASA Technical Reports Server (NTRS)

Melick, H. C., Jr.

1973-01-01

The effect of steady state circumferential total pressure distortion on the loss in compressor stall pressure ratio has been established by analytical techniques. Full scale engine and compressor/fan component test data were used to provide direct evaluation of the analysis. Specifically, since a circumferential total pressure distortion in an inlet system will result in unsteady flow in the coordinate system of the rotor blades, analysis of this type distortion must be performed from an unsteady aerodynamic point of view. By application of the fundamental aerothermodynamic laws to the inlet/compressor system, parameters important in the design of such a system for compatible operation have been identified. A time constant, directly related to the compressor rotor chord, was found to be significant, indicating compressor sensitivity to circumferential distortion is directly dependent on the rotor chord.

Double throat pressure pulsation dampener for oil-free screw compressors

NASA Astrophysics Data System (ADS)

Lucas, Michael J.

2005-09-01

This paper describes a recent invention at Ingersoll-Rand for reducing the pressure pulsations in an oil-free screw compressor. Pressure pulsation is a term used in the air compressor industry to describe the rapid change in pressure with time measured in the downstream piping of the air compressor. The pulsations are due to the rapid opening and closing of the screws as the compressed air is eject from the compressor into the piping system. The pulsations are known to produce excessive noise levels and high levels of vibration in the piping system. Reducing these pulsations is critical to achieving a quiet running compressor. This paper will describe the methodology used to analyze the data and show both computational and experimental results achieved using the pulsation dampener. A patent for this design has been filed with the US patent office.

Centrifugal compressor design for electrically assisted boost

NASA Astrophysics Data System (ADS)

Y Yang, M.; Martinez-Botas, R. F.; Zhuge, W. L.; Qureshi, U.; Richards, B.

2013-12-01

Electrically assisted boost is a prominent method to solve the issues of transient lag in turbocharger and remains an optimized operation condition for a compressor due to decoupling from turbine. Usually a centrifugal compressor for gasoline engine boosting is operated at high rotational speed which is beyond the ability of an electric motor in market. In this paper a centrifugal compressor with rotational speed as 120k RPM and pressure ratio as 2.0 is specially developed for electrically assisted boost. A centrifugal compressor including the impeller, vaneless diffuser and the volute is designed by meanline method followed by 3D detailed design. Then CFD method is employed to predict as well as analyse the performance of the design compressor. The results show that the pressure ratio and efficiency at design point is 2.07 and 78% specifically.

The influence of wedge diffuser blade number and divergence angle on the performance of a high pressure ratio centrifugal compressor

NASA Astrophysics Data System (ADS)

Wang, Yi; Han, Ge; Lu, Xingen; Zhu, Junqiang

2018-02-01

Wedge diffuser is widely used in centrifugal compressors due to its high performance and compact size. This paper is aimed to research the influence of wedge diffuser blade number and divergence angle on centrifugal compressor performance. The impact of wedge diffuser blade number on compressor stage performance is investigated, and then the wedge diffusers with different divergence angle are studied by varying diffuser wedge angle and blade number simultaneously. It is found that wedge diffuser with 27 blades could have about 0.8% higher adiabatic efficiency and 0.14 higher total pressure ratio than the wedge diffuser with 19 blades and the best compressor performance is achieved when diffuser divergence angle is 8.3°.These results could give some advices on centrifugal compressor design.

Design features of fans, blowers, and compressors

NASA Astrophysics Data System (ADS)

Cheremisinoff, N. P.; Cheremisinoff, P. N.

Fan engineering and compression machines are discussed. Basic aspects of fan performance and design are reviewed, and the design and performance characteristics of radial-flow fans, axial-flow fans, and controllable pitch fans are examined in detail. Air-conditioning systems are discussed, and noise, vibration, and mechanical considerations in fans are extensively examined. The thermodynamic principles governing compression machines are reviewed, and piston compressors, rotary compressors, blowers, and centrifugal compressors are discussed.

Transonic Fan/Compressor Rotor Design Study. Volume 3

DTIC Science & Technology

1982-02-01

KEY WORDS (Continue on revere. old. $1 nocoeoary and identify by block nuvb.,) Fan Aircraft Engines Compressor Blade Thickne)s Rotor Camber...COMPRESSOR ’Q ROTOR DESIGN STUDY Volume III D.E. Parker and M.R. Simonson CZ) General Electric Company Aircraft Engine Business Group Advanced...Compressor Research Group Chief, Technology Branch FOR THE COMMANDER H. WAN BI Director, Turbine Engine Division ŕ *If your address has changed, if you wish

Gas-turbine expander power generating systems for internal needs of compressor stations of gas-main pipelines

NASA Astrophysics Data System (ADS)

Shimanov, A. A.; Biryuk, V. V.; Sheludko, L. P.; Shabanov, K. Yu.

2017-08-01

In the framework of this paper, there have been analyzed power station building methods to construct a power station for utilities for gas-main pipelines compressor stations. The application efficiency of turbo expanders in them to expand the power gas of compressor stations' gas compressor units has been shown. New schemes for gas-turbine expander power generating systems have been proposed.

Solar-Powered Refrigeration System

NASA Technical Reports Server (NTRS)

Ewert, Michael K. (Inventor); Bergeron, David J., III (Inventor)

2001-01-01

A solar powered vapor compression refrigeration system is made practicable with thermal storage and novel control techniques. In one embodiment, the refrigeration system includes a photovoltaic panel, a variable speed compressor, an insulated enclosure. and a thermal reservoir. The photovoltaic (PV) panel converts sunlight into DC (direct current) electrical power. The DC electrical power drives a compressor that circulates refrigerant through a vapor compression refrigeration loop to extract heat from the insulated enclosure. The thermal reservoir is situated inside the insulated enclosure and includes a phase change material. As heat is extracted from the insulated enclosure, the phase change material is frozen, and thereafter is able to act as a heat sink to maintain the temperature of the insulated enclosure in the absence of sunlight. The conversion of solar power into stored thermal energy is optimized by a compressor control method that effectively maximizes the compressor's usage of available energy. A capacitor is provided to smooth the power voltage and to provide additional current during compressor start-up. A controller monitors the rate of change of the smoothed power voltage to determine if the compressor is operating below or above the available power maximum, and adjusts the compressor speed accordingly. In this manner, the compressor operation is adjusted to convert substantially all available solar power into stored thermal energy.

Solar-Powered Refrigeration System

NASA Technical Reports Server (NTRS)

Ewert, Michael K. (Inventor); Bergeron, David J., III (Inventor)

2002-01-01

A solar powered vapor compression refrigeration system is made practicable with thermal storage and novel control techniques. In one embodiment, the refrigeration system includes a photovoltaic panel, a variable speed compressor, an insulated enclosure, and a thermal reservoir. The photovoltaic (PV) panel converts sunlight into DC (direct current) electrical power. The DC electrical power drives a compressor that circulates refrigerant through a vapor compression refrigeration loop to extract heat from the insulated enclosure. The thermal reservoir is situated inside the insulated enclosure and includes a phase change material. As heat is extracted from the insulated enclosure, the phase change material is frozen, and thereafter is able to act as a heat sink to maintain the temperature of the insulated enclosure in the absence of sunlight. The conversion of solar power into stored thermal energy is optimized by a compressor control method that effectively maximizes the compressor's usage of available energy. A capacitor is provided to smooth the power voltage and to provide additional current during compressor start-up. A controller monitors the rate of change of the smoothed power voltage to determine if the compressor is operating below or above the available power maximum, and adjusts the compressor speed accordingly. In this manner, the compressor operation is adjusted to convert substantially all available solar power into stored thermal energy.

Solar Powered Refrigeration System

NASA Technical Reports Server (NTRS)

Ewert, Michael K. (Inventor); Bergeron, David J., III (Inventor)

2002-01-01

A solar powered vapor compression refrigeration system is made practicable with thermal storage and novel control techniques. In one embodiment, the refrigeration system includes a photovoltaic panel, a variable speed compressor, an insulated enclosure, and a thermal reservoir. The photovoltaic (PV) panel converts sunlight into DC (direct current) electrical power. The DC electrical power drives a compressor that circulates refrigerant through a vapor compression refrigeration loop to extract heat from the insulated enclosure. The thermal reservoir is situated inside the insulated enclosure and includes a phase change material. As heat is extracted from the insulated enclosure, the phase change material is frozen, and thereafter is able to act as a heat sink to maintain the temperature of the insulated enclosure in the absence of sunlight. The conversion of solar power into stored thermal energy is optimized by a compressor control method that effectively maximizes the compressor's usage of available energy. A capacitor is provided to smooth the power voltage and to provide additional current during compressor start-up. A controller monitors the rate of change of the smoothed power voltage to determine if the compressor is operating below or above the available power maximum, and adjusts the compressor speed accordingly. In this manner, the compressor operation is adjusted to convert substantially all available solar power into stored thermal energy.

Fluid-structure interaction analysis and lifetime estimation of a natural gas pipeline centrifugal compressor under near-choke and near-surge conditions

NASA Astrophysics Data System (ADS)

Ju, Yaping; Liu, Hui; Yao, Ziyun; Xing, Peng; Zhang, Chuhua

2015-11-01

Up to present, there have been no studies concerning the application of fluid-structure interaction (FSI) analysis to the lifetime estimation of multi-stage centrifugal compressors under dangerous unsteady aerodynamic excitations. In this paper, computational fluid dynamics (CFD) simulations of a three-stage natural gas pipeline centrifugal compressor are performed under near-choke and near-surge conditions, and the unsteady aerodynamic pressure acting on impeller blades are obtained. Then computational structural dynamics (CSD) analysis is conducted through a one-way coupling FSI model to predict alternating stresses in impeller blades. Finally, the compressor lifetime is estimated using the nominal stress approach. The FSI results show that the impellers of latter stages suffer larger fluctuation stresses but smaller mean stresses than those at preceding stages under near-choke and near-surge conditions. The most dangerous position in the compressor is found to be located near the leading edge of the last-stage impeller blade. Compressor lifetime estimation shows that the investigated compressor can run up to 102.7 h under the near-choke condition and 200.2 h under the near-surge condition. This study is expected to provide a scientific guidance for the operation safety of natural gas pipeline centrifugal compressors.

Design and development of a four-cell sorption compressor based J-T cooler using R134a as working fluid

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mehta, R. N.; Bapat, S. L.; Atrey, M. D.

The need of a cooler with no electromagnetic interference and practically zero vibration has led to sorption compressor based Joule-Thomson (J-T) coolers. These are useful for sophisticated electronic, ground based and space borne systems. In a Sorption compressor, adsorbed gases are desorbed into a confined volume by raising temperature of the sorption bed resulting in an increase in pressure of the liberated gas. In order to have the system (compressor) functioning on a continuous basis, with almost a constant gas flow rate, multiple cells are used with the adaptation of Temperature Swing Adsorption (TSA) process. As the mass of themore » desorbed gas dictates the compressor throughput, a combination of sorbent material with high adsorption capacity for a chosen gas or gas mixture has to be selected for efficient operation of the compressor. Commercially available (coconut-shell base) activated carbon has been selected for the present application. The characterization study for variation of discharge pressure is used to design the Four-cell sorption compressor based cryocooler with a desired output. Apart from compressor, the system includes a) After cooler b) Return gas heat exchanger c) capillary tube as the J-T expansion device and d) Evaporator.« less

Design and development of a four-cell sorption compressor based J-T cooler using R134a as working fluid

NASA Astrophysics Data System (ADS)

Mehta, R. N.; Bapat, S. L.; Atrey, M. D.

2014-01-01

The need of a cooler with no electromagnetic interference and practically zero vibration has led to sorption compressor based Joule-Thomson (J-T) coolers. These are useful for sophisticated electronic, ground based and space borne systems. In a Sorption compressor, adsorbed gases are desorbed into a confined volume by raising temperature of the sorption bed resulting in an increase in pressure of the liberated gas. In order to have the system (compressor) functioning on a continuous basis, with almost a constant gas flow rate, multiple cells are used with the adaptation of Temperature Swing Adsorption (TSA) process. As the mass of the desorbed gas dictates the compressor throughput, a combination of sorbent material with high adsorption capacity for a chosen gas or gas mixture has to be selected for efficient operation of the compressor. Commercially available (coconut-shell base) activated carbon has been selected for the present application. The characterization study for variation of discharge pressure is used to design the Four-cell sorption compressor based cryocooler with a desired output. Apart from compressor, the system includes a) After cooler b) Return gas heat exchanger c) capillary tube as the J-T expansion device and d) Evaporator.

Analysis of rig test data for an axial/centrifugal compressor in the 12 kg/sec

NASA Technical Reports Server (NTRS)

Owen, A. K.

1994-01-01

Extensive testing was done on a T55-L-712 turboshaft engine compressor in a compressor test rig at TEXTRON/Lycoming. These rig tests will be followed by a series of engine tests to occur at the NASA Lewis Research Center beginning in the last quarter of 1993. The goals of the rig testing were: (1) map the steady state compressor operation from 20 percent to 100 percent design speed, (2) quantify the effects of compressor bleed on the operation of the compressor, and (3) explore and measure the operation of the compressor in the flow ranges 'beyond' the normal compressor stall line. Instrumentation consisted of 497 steady state pressure sensors, 153 temperature sensors and 34 high response transducers for transient analysis in the pre- and post-stall operating regime. These measurements allow for generation of detailed stage characteristics as well as overall mapping. Transient data is being analyzed for the existence of modal disturbances at the front face of the compression system ('stall precursors'). This paper presents some preliminary results of the ongoing analysis and a description of the current and future program plans. It will primarily address the unsteady events at the front face of the compression system that occur as the system transitions from steady state to unsteady (stall/surge) operation.

Deaths Due to Accidental Air Conditioner Compressor Explosion: A Case Series.

PubMed

Behera, Chittaranjan; Bodwal, Jatin; Sikary, Asit K; Chauhan, Mohit Singh; Bijarnia, Manjul

2017-01-01

In an air-conditioning system, the compressor is a large electric pump that pressurizes the refrigerant gas as part of the process of turning it back into a liquid. The explosion of an air conditioner (AC) compressor is an uncommon event, and immediate death resulted from the blast effect is not reported in forensic literature. We report three such cases in which young AC mechanics were killed on the spot due to compressor blast, while repairing the domestic split AC unit. The autopsy findings, the circumstances leading to the explosion of the compressor, are discussed in this study. © 2016 American Academy of Forensic Sciences.

A miniature Rotary Compressor with a 1:10 compression ratio

NASA Astrophysics Data System (ADS)

Dmitriev, Olly; Tabota, Eugene; Arbon EurIng, Ian; FIMechE, CEng

2015-08-01

Micro compressors have applications in medical devices, robotics and “nanosatellites”. The problem of active cooling for photo detectors in “nano-satellites” becomes more important because the majority of space missions target Earth observation, and passive cooling does not provide the required temperatures to achieve the desired SNR levels. Reciprocating compressors used in cryocoolers cause vibrations. VERT Rotors has built an ultralow-vibration rotary compressor with 40mm-long screws, and our prototype delivered 1:10 compression ratio. This “nano” compressor is a non-conventional conical type consisting of an Inner conical screw rotor revolving inside an Outer screw rotor.

Development of an adsorption compressor for use in cryogenic refrigeration

NASA Technical Reports Server (NTRS)

Schember, Helen R.

1989-01-01

A new compressor with no moving parts has been developed which is able to supply a source of high-pressure gas to a Joule-Thompson based cryogenic refrigerator. The compressor relies on a newly implemented combination of high-surface-area Saran carbon (sorbent) and krypton gas (working fluid). In addition, an integral gas-gap heat switch is used to provide improved overall efficiency. A prototype compressor has been designed, built, and tested as a part of the Jet Propulsion Laboratory effort in sorption refrigeration. Performance data from the prototype unit described here demonstrate successful compressor performance and good agreement with theoretical predictions.

The importance of age and statin therapy in the interpretation of Lp-PLA(2) in ACS patients, and relation to CRP.

PubMed

Franeková, J; Kettner, J; Kubíček, Z; Jabor, A

2015-01-01

C-reactive protein (CRP) is a marker of arterial inflammation while lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is related to plaque instability. The aim of this study was to evaluate the correlation between the risk of unstable plaque presenting as acute coronary syndrome (ACS) and Lp-PLA(2), and to assess the influence of statins on interpretation of Lp-PLA(2). A total of 362 consecutive patients presenting to the emergency department (ED) with acute chest pain suggestive of ACS were evaluated by cardiologists as STEMI, NSTEMI, or unstable angina, and non-ACS. Serum biomarkers measured on admission: troponin I, C-reactive protein (Abbott), and Lp-PLA(2) (DiaDexus). Four groups were defined according to the final diagnosis and history of statin medication: ACS/statin-; ACS/statin+; non-ACS/statin-; non-ACS/statin+. Lp-PLA(2) was highest in ACS/statin- group; statins decreased Lp-PLA(2) both in ACS and non-ACS of about 20 %. Lp-PLA(2) was higher in ACS patients in comparison with non-ACS patients group without respect to statin therapy (p<0.001). Lp-PLA(2) predicted worse outcome (in terms of acute coronary syndrome) effectively in patients up to 62 years; limited prediction was found in older patients. C-reactive protein (CRP) failed to discriminate four groups of patients. Statin therapy and age should be taken into consideration while interpreting Lp-PLA(2) concentrations and lower cut-off values should be used for statin-treated persons.

ApoA-I/A-II-HDL positively associates with apoB-lipoproteins as a potential atherogenic indicator.

PubMed

Kido, Toshimi; Kondo, Kazuo; Kurata, Hideaki; Fujiwara, Yoko; Urata, Takeyoshi; Itakura, Hiroshige; Yokoyama, Shinji

2017-11-29

We recently reported distinct nature of high-density lipoproteins (HDL) subgroup particles with apolipoprotein (apo) A-I but not apoA-II (LpAI) and HDL having both (LpAI:AII) based on the data from 314 Japanese. While plasma HDL level almost exclusively depends on concentration of LpAI having 3 to 4 apoA-I molecules, LpAI:AII appeared with almost constant concentration regardless of plasma HDL levels having stable structure with two apoA-I and one disulfide-dimeric apoA-II molecules (Sci. Rep. 6; 31,532, 2016). The aim of this study is further characterization of LpAI:AII with respect to its role in atherogenesis. Association of LpAI, LpAI:AII and other HDL parameters with apoB-lipoprotein parameters was analyzed among the cohort data above. ApoA-I in LpAI negatively correlated with the apoB-lipoprotein parameters such as apoB, triglyceride, nonHDL-cholesterol, and nonHDL-cholesterol + triglyceride, which are apparently reflected in the relations of the total HDL parameters to apoB-lipoproteins. In contrast, apoA-I in LpAI:AII and apoA-II positively correlated to the apoB-lipoprotein parameters even within their small range of variation. These relationships are independent of sex, but may slightly be influenced by the activity-related CETP mutations. The study suggested that LpAI:AII is an atherogenic indicator rather than antiatherogenic. These sub-fractions of HDL are to be evaluated separately for estimating atherogenic risk of the patients.

49 CFR 230.71 - Orifice testing of compressors.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Compressor size Single strokes per minute Diameter of orifice(in inches) Air pressure maintained(in pounds... feet the speed of compressor may be increased 5 single strokes per minute for each 1,000 feet increase...

49 CFR 230.71 - Orifice testing of compressors.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Compressor size Single strokes per minute Diameter of orifice(in inches) Air pressure maintained(in pounds... feet the speed of compressor may be increased 5 single strokes per minute for each 1,000 feet increase...

49 CFR 230.71 - Orifice testing of compressors.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Compressor size Single strokes per minute Diameter of orifice(in inches) Air pressure maintained(in pounds... feet the speed of compressor may be increased 5 single strokes per minute for each 1,000 feet increase...

49 CFR 230.71 - Orifice testing of compressors.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Compressor size Single strokes per minute Diameter of orifice(in inches) Air pressure maintained(in pounds... feet the speed of compressor may be increased 5 single strokes per minute for each 1,000 feet increase...

49 CFR 230.71 - Orifice testing of compressors.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Compressor size Single strokes per minute Diameter of orifice(in inches) Air pressure maintained(in pounds... feet the speed of compressor may be increased 5 single strokes per minute for each 1,000 feet increase...

[Lipoprotein (a) in an urban population of Venezuela: Evidence that estrogenic deprivation increase in lipoprotein (a) levels is transitory].

PubMed

Bermúdez Pirela, V; Cabrera de Bravo, M; Mengual Moreno, E; Cano Ponce, C; Leal González, E; Lemus Antepaz, M; Amell de Díaz, A; Sorell Gómez, L

2007-07-01

Lipoprotein (a) [Lp (a)] is an independent risk factor for coronary artery disease and normal serum levels of this particle is not known in our country. Thus, the aim of this study was to determine plasma Lp (a) concentration in a population sample of Maracaibo. Fifth hundred out-patients, consulting at Centro de Investigaciones Endocrino-Metabólicas "Dr. Félix Gómez" were randomly underwent to venipunction to obtain a fasting blood simple to assess Lp (a) by a ELISA assay. No significantly differences were found when compared by sex or age separately, higher levels in Lp (a) was found in female 40-44 year group (median: 20,9 mg/dl). Thus, female population was divided in two sub-groups: < 40 years (median: 13 mg/dl) 40 yr and more (median: 16 mg/dl), finding higher Lp (a) levels in the second group (p < 0,02). Hormonal replace therapy was assessed by age, resulting that women subjected this approach shows lower levels of Lp (a) (p < 0,01), except in 60-64 year group. Lp (a) in a Maracaibo was within normal levels. Hormonal replace therapy diminishes Lp (a) concentration in menopausal women, but in menopausal women without hormonal therapy Lp (a) levels experienced a sustained decrease to normal levels in a age-depended manner.

Lactobacillus plantarum TWK10 Supplementation Improves Exercise Performance and Increases Muscle Mass in Mice

PubMed Central

Chen, Yi-Ming; Wei, Li; Chiu, Yen-Shuo; Hsu, Yi-Ju; Tsai, Tsung-Yu; Wang, Ming-Fu; Huang, Chi-Chang

2016-01-01

Lactobacillus plantarum (L. plantarum) is a well-known probiotic among the ingested-microorganism probiotics (i.e., ingested microorganisms associated with beneficial effects for the host). However, few studies have examined the effects of L. plantarum TWK10 (LP10) supplementation on exercise performance, physical fatigue, and gut microbial profile. Male Institute of Cancer Research (ICR) strain mice were divided into three groups (n = 8 per group) for oral administration of LP10 for six weeks at 0, 2.05 × 108, or 1.03 × 109 colony-forming units/kg/day, designated the vehicle, LP10-1X and LP10-5X groups, respectively. LP10 significantly decreased final body weight and increased relative muscle weight (%). LP10 supplementation dose-dependently increased grip strength (p < 0.0001) and endurance swimming time (p < 0.001) and decreased levels of serum lactate (p < 0.0001), ammonia (p < 0.0001), creatine kinase (p = 0.0118), and glucose (p = 0.0151) after acute exercise challenge. The number of type I fibers (slow muscle) in gastrocnemius muscle significantly increased with LP10 treatment. In addition, serum levels of albumin, blood urea nitrogen, creatinine, and triacylglycerol significantly decreased with LP10 treatment. Long-term supplementation with LP10 may increase muscle mass, enhance energy harvesting, and have health-promotion, performance-improvement, and anti-fatigue effects. PMID:27070637

The renaissance of lipoprotein(a): Brave new world for preventive cardiology?

PubMed

Ellis, Katrina L; Boffa, Michael B; Sahebkar, Amirhossein; Koschinsky, Marlys L; Watts, Gerald F

2017-10-01

Lipoprotein(a) [Lp(a)] is a highly heritable cardiovascular risk factor. Although discovered more than 50 years ago, Lp(a) has recently re-emerged as a major focus in the fields of lipidology and preventive cardiology owing to findings from genetic studies and the possibility of lowering elevated plasma concentrations with new antisense therapy. Data from genetic, epidemiological and clinical studies have provided compelling evidence establishing Lp(a) as a causal risk factor for atherosclerotic cardiovascular disease. Nevertheless, major gaps in knowledge remain and the identification of the mechanistic processes governing both Lp(a) pathobiology and metabolism are an ongoing challenge. Furthermore, the complex structure of Lp(a) presents a major obstacle to the accurate quantification of plasma concentrations, and a universally accepted and standardized approach for measuring Lp(a) is required. Significant progress has been made in the development of novel therapeutics for selectively lowering Lp(a). However, before these therapies can be widely implemented further investigations are required to assess their efficacy, safety, and cost-efficiency in the prevention of cardiovascular events. We review recent advances in molecular and biochemical aspects, epidemiology, and pathobiology of Lp(a), and provide a contemporary update on the significance of Lp(a) in clinical medicine. "Progress lies not in enhancing what is, but in advancing toward what will be." (Khalil Gibran). Copyright © 2017 Elsevier Ltd. All rights reserved.

A model for the selective amplification of spatially coherent waves in a centrifugal compressor on the verge of rotating stall

NASA Technical Reports Server (NTRS)

Lawless, Patrick B.; Fleeter, Sanford

1993-01-01

A simple model for the stability zones of a low speed centrifugal compressor is developed, with the goal of understanding the driving mechanism for the changes in stalling behavior predicted for, and observed in, the Purdue Low Speed Centrifugal Research Compressor Facility. To this end, earlier analyses of rotating stall suppression in centrifugal compressors are presented in a reduced form that preserves the essential parameters of the model that affect the stalling behavior of the compressor. The model is then used to illuminate the relationship between compressor geometry, expected mode shape, and regions of amplification for weak waves which are indicative of the susceptibility of the system to rotating stall. The results demonstrate that increasing the stagger angle of the diffuser vanes, and consequently the diffusion path length, results in the compressor moving towards a condition where higher-order spatial modes are excited during stall initiation. Similarly, flow acceleration in the diffuser section caused by an increase in the number of diffuser vanes also results in the excitation of higher modes.

Active unsteady aerodynamic suppression of rotating stall in an incompressible flow centrifugal compressor with vaned diffuser

NASA Technical Reports Server (NTRS)

Lawless, Patrick B.; Fleeter, Sanford

1991-01-01

A mathematical model is developed to analyze the suppression of rotating stall in an incompressible flow centrifugal compressor with a vaned diffuser, thereby addressing the important need for centrifugal compressor rotating stall and surge control. In this model, the precursor to to instability is a weak rotating potential velocity perturbation in the inlet flow field that eventually develops into a finite disturbance. To suppress the growth of this potential disturbance, a rotating control vortical velocity disturbance is introduced into the impeller inlet flow. The effectiveness of this control is analyzed by matching the perturbation pressure in the compressor inlet and exit flow fields with a model for the unsteady behavior of the compressor. To demonstrate instability control, this model is then used to predict the control effectiveness for centrifugal compressor geometries based on a low speed research centrifugal compressor. These results indicate that reductions of 10 to 15 percent in the mean inlet flow coefficient at instability are possible with control waveforms of half the magnitude of the total disturbance at the inlet.

Turbine engine

DOE Office of Scientific and Technical Information (OSTI.GOV)

Greer, D.

1988-02-16

In a turbine propulsion engine, an elongated motor is described including a power means and having a drive shaft projecting therefrom. A first compressor includes an elongated rotatable first casing coaxially mounted upon the motor having a fuel inlet for pressure feeding of fuel lengthwise of the first compressor. A second compressor includes a casing coaxially mounted upon and along the first compressor casing secured to the motor having an air inlet at its forward end for feeding high velocity compressed air lengthwise of the second compressor casing. An intermediate diverging casing at one end is peripherally connected to themore » second compressor casing having inner and outer diffusor chambers communicating respectively with the compressor for receiving high velocity vaporized fuel and compressed air. A turbine casing at one end is peripherally connected to the intermediate casing and at its other end having a converging exhaust outlet. An elongated combustion chamber of circular cross-section rotatably mounted and spaced within and journaled upon the turbine casing; an engine shaft extending axially through the combustion chamber, journaled upon the turbine casing and axially connected to the drive shaft.« less

Space shuttle phase B. Volume 2: Technical summary, addendum A

NASA Technical Reports Server (NTRS)

1971-01-01

A study was conducted to analyze the characteristics and performance data for the booster vehicles to be used with the space shuttle operations. It was determined that the single pressure-fed booster offered the lowest program cost per flight of the pressure-fed booster arrangements studied. The fly back booster required the highest peak annual funding and highest program cost. It was recommended that the pressure-fed booster, series burn with liquid oxygen phase, be continued for further study. The flyback booster study was discontinued. Both solid and liquid propelled booster vehicles with 14 by 45 foot and 15 by 60 foot payload orbiters were considered.

75 FR 32181 - Change in Bank Control Notices; Acquisition of Shares of Bank or Bank Holding Companies

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-07

... Investment Management, L.L.C.; TC Group, L.L.C.; and TCG Holdings, L.L.C., all of Wilmington, Delaware; to... Partners, L.P.; TCG Financial Services, L.P.; Carlyle Financial Services, Ltd.; TC Group Cayman Investment Holdings, L.P.; TCG Holdings Cayman II, L.P.; DBD Cayman, Limited; TCG Financial Services Investment...

Lipoprotein(a) levels, apo(a) isoform size, and coronary heart disease risk in the Framingham Offspring Study

USDA-ARS?s Scientific Manuscript database

The aim of this study was to assess the independent contributions of plasma levels of lipoprotein(a) [Lp(a)], Lp(a) cholesterol, and of apo(a) isoform size to prospective coronary heart disease (CHD) risk. Plasma Lp(a) and Lp(a) cholesterol levels, and apo(a) isoform size were measured at examinati...

Intestinal lamina propria dendritic cells maintain T cell homeostasis but do not affect commensalism

PubMed Central

Welty, Nathan E.; Staley, Christopher; Ghilardi, Nico; Sadowsky, Michael J.; Igyártó, Botond Z.

2013-01-01

Dendritic cells (DCs) in the intestinal lamina propria (LP) are composed of two CD103+ subsets that differ in CD11b expression. We report here that Langerin is expressed by human LP DCs and that transgenic human langerin drives expression in CD103+CD11b+ LP DCs in mice. This subset was ablated in huLangerin-DTA mice, resulting in reduced LP Th17 cells without affecting Th1 or T reg cells. Notably, cognate DC–T cell interactions were not required for Th17 development, as this response was intact in huLangerin-Cre I-Aβfl/fl mice. In contrast, responses to intestinal infection or flagellin administration were unaffected by the absence of CD103+CD11b+ DCs. huLangerin-DTA x BatF3−/− mice lacked both CD103+ LP DC subsets, resulting in defective gut homing and fewer LP T reg cells. Despite these defects in LP DCs and resident T cells, we did not observe alterations of intestinal microbial communities. Thus, CD103+ LP DC subsets control T cell homeostasis through both nonredundant and overlapping mechanisms. PMID:24019552

Lack of evidence for hepatitis C virus infection in association with lichen planus.

PubMed

Stojanovic, Larisa; Lunder, Tomaz; Poljak, Mario; Mars, Tomaz; Mlakar, Bostjan; Maticic, Mojca

2008-12-01

The association between hepatitis C virus (HCV) infection and lichen planus (LP) is a subject of controversy. Prevalence studies of HCV infection in LP patients in various countries reveal diverse results. The Slovenian population is rather homogenous with specific geographic and epidemiological characteristics. Lack of data or contradictory results from neighboring countries urged the need for a case-controlled study in our LP patients. The retrospective study was performed on 173 LP patients. Control group included 218 patients with dermatological diseases other than LP. Anti-HCV antibodies were found in 2/173 patients (1.2%) with LP and in 0/218 controls. No statistically significant difference was found between the study and control group regarding anti-HCV antibody prevalence (P = 0.195; estimated OR 6.4, 95% CI 0.3-134.0) and risk factors for HCV infection. Based on our results, anti-HCV antibody testing is not necessarily required in LP patients with no risk factors for HCV infection in this geographic region.

Six mode selective fiber optic spatial multiplexer.

PubMed

Velazquez-Benitez, A M; Alvarado, J C; Lopez-Galmiche, G; Antonio-Lopez, J E; Hernández-Cordero, J; Sanchez-Mondragon, J; Sillard, P; Okonkwo, C M; Amezcua-Correa, R

2015-04-15

Low-loss all-fiber photonic lantern (PL) mode multiplexers (MUXs) capable of selectively exciting the first six fiber modes of a multimode fiber (LP₀₁, LP_11a, LP_11b, LP_21a, LP_21b, and LP₀₂) are demonstrated. Fabrication of the spatial mode multiplexers was successfully achieved employing a combination of either six step or six graded index fibers of four different core sizes. Insertion losses of 0.2-0.3 dB and mode purities above 9 dB are achieved. Moreover, it is demonstrated that the use of graded index fibers in a PL eases the length requirements of the adiabatic tapered transition and could enable scaling to large numbers.

Five-Segment Reusable Solid Rocket Booster Upgrade

NASA Technical Reports Server (NTRS)

Sauvageau, Don

1999-01-01

The Five Segment Reusable Solid Rocket Booster (RSRB) feasibility status is presented in viewgraph form. The Five Segment Booster (FSB) objective is to provide a low cost, low risk approach to increase reliability and safety of the Shuttle system. Topics include: booster upgrade requirements; design summary; reliability issues; booster trajectories; launch site assessment; and enhanced abort modes.

30 CFR 57.8518 - Main and booster fans.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Main and booster fans. 57.8518 Section 57.8518... and Underground § 57.8518 Main and booster fans. (a) All mine main and booster fans installed and used..., or adjustments. (b) In the event of main or booster fan failure due to a malfunction, accident, power...

30 CFR 57.8518 - Main and booster fans.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Main and booster fans. 57.8518 Section 57.8518... and Underground § 57.8518 Main and booster fans. (a) All mine main and booster fans installed and used..., or adjustments. (b) In the event of main or booster fan failure due to a malfunction, accident, power...

30 CFR 57.8518 - Main and booster fans.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Main and booster fans. 57.8518 Section 57.8518... and Underground § 57.8518 Main and booster fans. (a) All mine main and booster fans installed and used..., or adjustments. (b) In the event of main or booster fan failure due to a malfunction, accident, power...

30 CFR 57.8518 - Main and booster fans.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Main and booster fans. 57.8518 Section 57.8518... and Underground § 57.8518 Main and booster fans. (a) All mine main and booster fans installed and used..., or adjustments. (b) In the event of main or booster fan failure due to a malfunction, accident, power...

30 CFR 57.8518 - Main and booster fans.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Main and booster fans. 57.8518 Section 57.8518... and Underground § 57.8518 Main and booster fans. (a) All mine main and booster fans installed and used..., or adjustments. (b) In the event of main or booster fan failure due to a malfunction, accident, power...

Integrated Heat Switch/Oxide Sorption Compressor

NASA Technical Reports Server (NTRS)

Bard, Steven

1989-01-01

Thermally-driven, nonmechanical compressor uses container filled with compressed praseodymium cerium oxide powder (PrCeOx) to provide high-pressure flow of oxygen gas for driving closed-cycle Joule-Thomson-expansion refrigeration unit. Integrated heat switch/oxide sorption compressor has no moving parts except check valves, which control flow of oxygen gas between compressor and closed-cycle Joule-Thomson refrigeration system. Oxygen expelled from sorbent at high pressure by evacuating heat-switch gap and turning on heater.

Scaled Centrifugal Compressor Program.

DTIC Science & Technology

1986-10-31

small compressors in turbo - shaft, turbofan , and turboprop engines used in rotorcraft; fixed-wing general aviation, and cruise missile aircraft . Included...AD-A±74 "I SCALED CENTRIFUGAL COMPRESSOR PEOGRAN(U) GARRETT13 TURBINE ENGINE CO PHOENIX AZ G CRGILL ET AL. 31 OCT 86 21-5464 MASA-CR-i?4912 NAS3...REPORT 6’ FOR SCALED CENTRIFUGAL COMPRESSOR PROGRAM GARRETT TURBINE ENGINE COMPANY A DIVISION OF THE GARRETT CORPORATION I111 SOUTH 34TH STREET - P.O

Variable speed gas engine-driven air compressor system

NASA Astrophysics Data System (ADS)

Morgan, J. R.; Ruggles, A. E.; Chen, T. N.; Gehret, J.

1992-11-01

Tecogen Inc. and Ingersoll-Rand Co. as a subcontractor have designed a nominal 150-hp gas engine-driven air compressor utilizing the TECODRIVE 8000 engine and the Ingersoll-Rand 178.5-mm twin screw compressor. Phase 1 included the system engineering and design, economic and applications studies, and a draft commercialization plan. Phase 2 included controls development, laboratory prototype construction, and performance testing. The testing conducted verified that the compressor meets all design specifications.

QRFXFreeze: Queryable Compressor for RFX.

PubMed

Senthilkumar, Radha; Nandagopal, Gomathi; Ronald, Daphne

2015-01-01

The verbose nature of XML has been mulled over again and again and many compression techniques for XML data have been excogitated over the years. Some of the techniques incorporate support for querying the XML database in its compressed format while others have to be decompressed before they can be queried. XML compression in which querying is directly supported instantaneously with no compromise over time is forced to compromise over space. In this paper, we propose the compressor, QRFXFreeze, which not only reduces the space of storage but also supports efficient querying. The compressor does this without decompressing the compressed XML file. The compressor supports all kinds of XML documents along with insert, update, and delete operations. The forte of QRFXFreeze is that the textual data are semantically compressed and are indexed to reduce the querying time. Experimental results show that the proposed compressor performs much better than other well-known compressors.

Modeling and design study using HFC-236ea as an alternative refrigerant in a centrifugal compressor. Final report, January 1994-September 1995

DOE Office of Scientific and Technical Information (OSTI.GOV)

Popovic, P.; Shapiro, H.N.

1997-04-01

The Environmental Protection Agency (EPA) in cooperation with the Navy has been seeking a CFC-114 drop-in placement. One alternative HFC refrigerant which appears to satisfy all physical and chemical characteristics for the Navy fleet was found to be HFC-236ea refrigerant. The project represents a part of the investigation directed to evaluate this CFC-114 alternative refrigerant as a possible drop-in replacement in Navy chillers. The objective of the study was to conduct a thorough literature review regarding centrifugal compressors and the, on the basis of the information gathered, build an accurate but simple compressor model utilizing the available compressor experimental data.more » Further, the developed compressor model would be used to suggest eventual design adjustments to enhance compressor performance with the alternative HFC-236ea refrigerant.« less

Experiments and modelling of surge in small centrifugal compressor for automotive engines

DOE Office of Scientific and Technical Information (OSTI.GOV)

Galindo, J.; Serrano, J.R.; Climent, H.

2008-01-15

In this paper the surge phenomenon in small centrifugal compressors used for turbocharging internal combustion engines is analyzed. The experimental work was focused on the measurement of compressor behaviour within the surge zone by means of a specifically designed facility. The presented model is based on the introduction of a fluid inertia term that accounts for the non quasi steady effects and the use of a compressor map extended to the surge and negative flows zone obtained from experimental tests. The compressor model was implemented in a one-dimensional gas-dynamic model. The comparison of the modelled and measured evolution of instantaneousmore » pressure during deep surge operation shows good agreement. Furthermore, the model is also able to predict the amplitude and frequency of pressure pulses when the compressor operates in surge with different outlet duct lengths. (author)« less

Determination of the oil distribution in a hermetic compressor using numerical simulation

NASA Astrophysics Data System (ADS)

Posch, S.; Hopfgartner, J.; Berger, E.; Zuber, B.; Almbauer, R.; Schöllauf, P.

2017-08-01

In addition to the reduction of friction the oil in a hermetic compressor is very important for the transfer of heat from hot parts to the compressor shell. The simulation of the oil distribution in a hermetic reciprocating compressor for refrigeration application is shown in the present work. Using the commercial Computational Fluid Dynamics (CFD) software ANSYS Fluent, the oil flow inside the compressor shell from the oil pump outlet to the oil sump is calculated. A comprehensive overview of the used models and the boundary conditions is given. After reaching steady-state conditions the oil covered surfaces are analysed concerning heat transfer coefficients. The gained heat transfer coefficients are used as input parameters for a thermal model of a hermetic compressor. An increase in accuracy of the thermal model with the simulated heat transfer coefficients compared to values from literature is shown by model validation with experimental data.

Conception of a test bench to generate known and controlled conditions of refrigerant mass flow.

PubMed

Martins, Erick F; Flesch, Carlos A; Flesch, Rodolfo C C; Borges, Maikon R

2011-07-01

Refrigerant compressor performance tests play an important role in the evaluation of the energy characteristics of the compressor, enabling an increase in the quality, reliability, and efficiency of these products. Due to the nonexistence of a refrigerating capacity standard, it is common to use previously conditioned compressors for the intercomparison and evaluation of the temporal drift of compressor performance test panels. However, there are some limitations regarding the use of these specific compressors as standards. This study proposes the development of a refrigerating capacity standard which consists of a mass flow meter and a variable-capacity compressor, whose speed is set based on the mass flow rate measured by the meter. From the results obtained in the tests carried out on a bench specifically developed for this purpose, it was possible to validate the concept of a capacity standard. Copyright © 2011 ISA. Published by Elsevier Ltd. All rights reserved.

Axial flow positive displacement worm compressor

NASA Technical Reports Server (NTRS)

Murrow, Kurt David (Inventor); Giffin, Rollin George (Inventor); Fakunle, Oladapo (Inventor)

2010-01-01

An axial flow positive displacement compressor has an inlet axially spaced apart and upstream from an outlet. Inner and outer bodies have offset inner and outer axes extend from the inlet to the outlet through first and second sections of a compressor assembly in serial downstream flow relationship. At least one of the bodies is rotatable about its axis. The inner and outer bodies have intermeshed inner and outer helical blades wound about the inner and outer axes respectively. The inner and outer helical blades extend radially outwardly and inwardly respectively. The helical blades have first and second twist slopes in the first and second sections respectively. The first twist slopes are less than the second twist slopes. An engine including the compressor has in downstream serial flow relationship from the compressor a combustor and a high pressure turbine drivingly connected to the compressor by a high pressure shaft.

Research and development of energy-efficient appliance motor-compressors. Volume IV. Production demonstration and field test

DOE Office of Scientific and Technical Information (OSTI.GOV)

Middleton, M.G.; Sauber, R.S.

Two models of a high-efficiency compressor were manufactured in a pilot production run. These compressors were for low back-pressure applications. While based on a production compressor, there were many changes that required production process changes. Some changes were performed within our company and others were made by outside vendors. The compressors were used in top mount refrigerator-freezers and sold in normal distribution channels. Forty units were placed in residences for a one-year field test. Additional compressors were built so that a life test program could be performed. The results of the field test reveal a 27.0% improvement in energy consumptionmore » for the 18 ft/sup 3/ high-efficiency model and a 15.6% improvement in the 21 ft/sup 3/ improvement in the 21 ft/sup 3/ high-efficiency model as compared to the standard production unit.« less

Complications after LP related to needle type: pencil-point versus Quincke.

PubMed

Aamodt, A; Vedeler, C

2001-06-01

We studied the incidence of complications after diagnostic lumbar puncture (LP) related to needle type. A 5 months' observational study of routine diagnostic LP in 83 patients was conducted. Significantly more headache was observed after LP using thicker cutting needles (20G Quincke) compared with thinner cutting or non-cutting needles (22G Quincke or pencil-point). No significant difference in complications after LP was found between the 22G Quincke and pencil-point needles. The size of the needle and not the needle shape seems to be the main determinant for post-dural puncture headache (PDPH).

Enfuvirtide (T20)-Based Lipopeptide Is a Potent HIV-1 Cell Fusion Inhibitor: Implications for Viral Entry and Inhibition.

PubMed

Ding, Xiaohui; Zhang, Xiujuan; Chong, Huihui; Zhu, Yuanmei; Wei, Huamian; Wu, Xiyuan; He, Jinsheng; Wang, Xinquan; He, Yuxian

2017-09-15

The peptide drug enfuvirtide (T20) is the only viral fusion inhibitor used in combination therapy for HIV-1 infection, but it has relatively low antiviral activity and easily induces drug resistance. Emerging studies demonstrate that lipopeptide-based fusion inhibitors, such as LP-11 and LP-19, which mainly target the gp41 pocket site, have greatly improved antiviral potency and in vivo stability. In this study, we focused on developing a T20-based lipopeptide inhibitor that lacks pocket-binding sequence and targets a different site. First, the C-terminal tryptophan-rich motif (TRM) of T20 was verified to be essential for its target binding and inhibition; then, a novel lipopeptide, termed LP-40, was created by replacing the TRM with a fatty acid group. LP-40 showed markedly enhanced binding affinity for the target site and dramatically increased inhibitory activity on HIV-1 membrane fusion, entry, and infection. Unlike LP-11 and LP-19, which required a flexible linker between the peptide sequence and the lipid moiety, addition of a linker to LP-40 sharply reduced its potency, implying different binding modes with the extended N-terminal helices of gp41. Also, interestingly, LP-40 showed more potent activity than LP-11 in inhibiting HIV-1 Env-mediated cell-cell fusion while it was less active than LP-11 in inhibiting pseudovirus entry, and the two inhibitors displayed synergistic antiviral effects. The crystal structure of LP-40 in complex with a target peptide revealed their key binding residues and motifs. Combined, our studies have not only provided a potent HIV-1 fusion inhibitor, but also revealed new insights into the mechanisms of viral inhibition. IMPORTANCE T20 is the only membrane fusion inhibitor available for treatment of viral infection; however, T20 requires high doses and has a low genetic barrier for resistance, and its inhibitory mechanism and structural basis remain unclear. Here, we report the design of LP-40, a T20-based lipopeptide inhibitor that has greatly improved anti-HIV activity and is a more potent inhibitor of cell-cell fusion than of cell-free virus infection. The binding modes of two classes of membrane-anchoring lipopeptides (LP-40 and LP-11) verify the current fusion model in which an extended prehairpin structure bridges the viral and cellular membranes, and their complementary effects suggest a vital strategy for combination therapy of HIV-1 infection. Moreover, our understanding of the mechanism of action of T20 and its derivatives benefits from the crystal structure of LP-40. Copyright © 2017 American Society for Microbiology.

Emulsion based cast booster - a priming system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gupta, R.N.; Mishra, A.K.

2005-07-01

This paper explores the potential of emulsion based cast booster to be used as primer to initiate bulk delivered emulsion explosives used in mines. An attempt has been made for comparative study between conventional cast booster and emulsion based cast booster in terms of the initiation process developed and their capability to develop and maintain the stable detonation process in the column explosives. The study has been conducted using a continuous velocity of detonation (VOD) measuring instrument. During this study three blasts have been monitored. In each blast two holes have been selected for study, the first hole being initiatedmore » with conventional cast booster while the other one with emulsion based cast booster. The findings of the study advocates that emulsion based cast booster is capable of efficient priming of bulk delivered column explosive with stable detonation process in the column. Further, the booster had advantages over the conventional PETN/TNT based cast booster. 5 refs., 2 figs., 1 tab., 1 photo.« less

47 CFR 74.15 - Station license period.

Code of Federal Regulations, 2011 CFR

2011-10-01

... broadcast booster station or a TV broadcast booster station will be issued for a period running concurrently... broadcast station, FM translator or FM broadcast booster, TV translator or TV broadcast booster, or low...

47 CFR 74.15 - Station license period.

Code of Federal Regulations, 2012 CFR

2012-10-01

... broadcast booster station or a TV broadcast booster station will be issued for a period running concurrently... broadcast station, FM translator or FM broadcast booster, TV translator or TV broadcast booster, or low...

Risk factors and outcomes for late presentation for HIV-positive persons in Europe: results from the Collaboration of Observational HIV Epidemiological Research Europe Study (COHERE).

PubMed

Mocroft, Amanda; Lundgren, Jens D; Sabin, Miriam Lewis; Monforte, Antonella d'Arminio; Brockmeyer, Norbert; Casabona, Jordi; Castagna, Antonella; Costagliola, Dominique; Dabis, Francois; De Wit, Stéphane; Fätkenheuer, Gerd; Furrer, Hansjakob; Johnson, Anne M; Lazanas, Marios K; Leport, Catherine; Moreno, Santiago; Obel, Niels; Post, Frank A; Reekie, Joanne; Reiss, Peter; Sabin, Caroline; Skaletz-Rorowski, Adriane; Suarez-Lozano, Ignacio; Torti, Carlo; Warszawski, Josiane; Zangerle, Robert; Fabre-Colin, Céline; Kjaer, Jesper; Chene, Genevieve; Grarup, Jesper; Kirk, Ole

2013-01-01

Few studies have monitored late presentation (LP) of HIV infection over the European continent, including Eastern Europe. Study objectives were to explore the impact of LP on AIDS and mortality. LP was defined in Collaboration of Observational HIV Epidemiological Research Europe (COHERE) as HIV diagnosis with a CD4 count <350/mm(3) or an AIDS diagnosis within 6 months of HIV diagnosis among persons presenting for care between 1 January 2000 and 30 June 2011. Logistic regression was used to identify factors associated with LP and Poisson regression to explore the impact on AIDS/death. 84,524 individuals from 23 cohorts in 35 countries contributed data; 45,488 were LP (53.8%). LP was highest in heterosexual males (66.1%), Southern European countries (57.0%), and persons originating from Africa (65.1%). LP decreased from 57.3% in 2000 to 51.7% in 2010/2011 (adjusted odds ratio [aOR] 0.96; 95% CI 0.95-0.97). LP decreased over time in both Central and Northern Europe among homosexual men, and male and female heterosexuals, but increased over time for female heterosexuals and male intravenous drug users (IDUs) from Southern Europe and in male and female IDUs from Eastern Europe. 8,187 AIDS/deaths occurred during 327,003 person-years of follow-up. In the first year after HIV diagnosis, LP was associated with over a 13-fold increased incidence of AIDS/death in Southern Europe (adjusted incidence rate ratio [aIRR] 13.02; 95% CI 8.19-20.70) and over a 6-fold increased rate in Eastern Europe (aIRR 6.64; 95% CI 3.55-12.43). LP has decreased over time across Europe, but remains a significant issue in the region in all HIV exposure groups. LP increased in male IDUs and female heterosexuals from Southern Europe and IDUs in Eastern Europe. LP was associated with an increased rate of AIDS/deaths, particularly in the first year after HIV diagnosis, with significant variation across Europe. Earlier and more widespread testing, timely referrals after testing positive, and improved retention in care strategies are required to further reduce the incidence of LP.

Temporal variability in lipoprotein(a) levels in patients enrolled in the placebo arms of IONIS-APO(a)Rx and IONIS-APO(a)-LRx antisense oligonucleotide clinical trials.

PubMed

Marcovina, Santica M; Viney, Nicholas J; Hughes, Steven G; Xia, Shuting; Witztum, Joseph L; Tsimikas, Sotirios

Lipoprotein(a) [Lp(a)] levels are primarily genetically determined, but their natural variability is not well known. The aim of the study was to evaluate the short-term temporal variability in Lp(a) in 3 placebo groups from the IONIS-APO(a) Rx and IONIS-APO(a)-L Rx trials. The placebo groups comprised 3 studies: Study 1 with 10 subjects with any Lp(a) concentration; Study 2 with 13 subjects with Lp(a) ≥75 nmol/L (∼30 mg/dL); and Study 3 with 29 patients with Lp(a) ≥125 nmol/L (≥∼50 mg/dL). Lp(a) was measured in serial blood samples (range 7-12 samples up to 190 days of follow-up) and analyzed as absolute change and mean percent change from baseline. Outliers were defined as having a > ±25% difference in Lp(a) from baseline at any future time point. No significant temporal differences in mean absolute Lp(a) levels were present in any group. However, among individuals, the mean change in absolute Lp(a) levels at any time point ranged from -16.2 to +7.0 nmol/L in Study 1, -15.8 to +9.8 nmol/L in Study 2, and -60.2 to +16.6 nmol/L in Study 3. The mean percent change from baseline ranged from -9.4% to +21.6% for Study 1, -13.1% to 2.8% for Study 2, and -12.1% to +4.9% in Study 3. A total of 21 of 52 subjects (40.4%) were outliers, with 13 (62%) >25% up and 8 (38%) >25% down. Significant variability was also noted in other lipid parameters, but no outliers were noted with serum albumin. In subjects randomized to placebo in Lp(a) lowering trials, modest intra-individual temporal variability of mean Lp(a) levels was present. Significant number of subjects had > ±25% variation in Lp(a) in at least 1 time point. Although Lp(a) levels are primarily genetically determined, further study is required to define additional factors mediating short-term variability. Copyright © 2017 National Lipid Association. Published by Elsevier Inc. All rights reserved.

Risk Factors and Outcomes for Late Presentation for HIV-Positive Persons in Europe: Results from the Collaboration of Observational HIV Epidemiological Research Europe Study (COHERE)

PubMed Central

Mocroft, Amanda; Lundgren, Jens D.; Sabin, Miriam Lewis; Monforte, Antonella d'Arminio; Brockmeyer, Norbert; Casabona, Jordi; Castagna, Antonella; Costagliola, Dominique; Dabis, Francois; De Wit, Stéphane; Fätkenheuer, Gerd; Furrer, Hansjakob; Johnson, Anne M.; Lazanas, Marios K.; Leport, Catherine; Moreno, Santiago; Obel, Niels; Post, Frank A.; Reekie, Joanne; Reiss, Peter; Sabin, Caroline; Skaletz-Rorowski, Adriane; Suarez-Lozano, Ignacio; Torti, Carlo; Warszawski, Josiane; Zangerle, Robert; Fabre-Colin, Céline; Kjaer, Jesper; Chene, Genevieve; Grarup, Jesper; Kirk, Ole

2013-01-01

Background Few studies have monitored late presentation (LP) of HIV infection over the European continent, including Eastern Europe. Study objectives were to explore the impact of LP on AIDS and mortality. Methods and Findings LP was defined in Collaboration of Observational HIV Epidemiological Research Europe (COHERE) as HIV diagnosis with a CD4 count <350/mm3 or an AIDS diagnosis within 6 months of HIV diagnosis among persons presenting for care between 1 January 2000 and 30 June 2011. Logistic regression was used to identify factors associated with LP and Poisson regression to explore the impact on AIDS/death. 84,524 individuals from 23 cohorts in 35 countries contributed data; 45,488 were LP (53.8%). LP was highest in heterosexual males (66.1%), Southern European countries (57.0%), and persons originating from Africa (65.1%). LP decreased from 57.3% in 2000 to 51.7% in 2010/2011 (adjusted odds ratio [aOR] 0.96; 95% CI 0.95–0.97). LP decreased over time in both Central and Northern Europe among homosexual men, and male and female heterosexuals, but increased over time for female heterosexuals and male intravenous drug users (IDUs) from Southern Europe and in male and female IDUs from Eastern Europe. 8,187 AIDS/deaths occurred during 327,003 person-years of follow-up. In the first year after HIV diagnosis, LP was associated with over a 13-fold increased incidence of AIDS/death in Southern Europe (adjusted incidence rate ratio [aIRR] 13.02; 95% CI 8.19–20.70) and over a 6-fold increased rate in Eastern Europe (aIRR 6.64; 95% CI 3.55–12.43). Conclusions LP has decreased over time across Europe, but remains a significant issue in the region in all HIV exposure groups. LP increased in male IDUs and female heterosexuals from Southern Europe and IDUs in Eastern Europe. LP was associated with an increased rate of AIDS/deaths, particularly in the first year after HIV diagnosis, with significant variation across Europe. Earlier and more widespread testing, timely referrals after testing positive, and improved retention in care strategies are required to further reduce the incidence of LP. Please see later in the article for the Editors' Summary PMID:24137103

Lipoprotein(a) and coronary atheroma progression rates during long-term high-intensity statin therapy: Insights from SATURN.

PubMed

Puri, Rishi; Ballantyne, Christie M; Hoogeveen, Ron C; Shao, Mingyuan; Barter, Philip; Libby, Peter; Chapman, M John; Erbel, Raimund; Arsenault, Benoit J; Raichlen, Joel S; Nissen, Steven E; Nicholls, Stephen J

2017-08-01

Lipoprotein(a) [Lp(a)] is a low-density lipoprotein (LDL)-like particle that associates with major adverse cardiovascular events (MACE). We examined relationships between Lp(a) measurements and changes in coronary atheroma volume following long-term maximally-intensive statin therapy in coronary artery disease patients. Study of coronary atheroma by intravascular ultrasound: Effect of Rosuvastatin Versus Atorvastatin (SATURN) used serial intravascular ultrasound measures of coronary atheroma volume in patients treated with rosuvastatin 40 mg or atorvastatin 80 mg for 24 months. Baseline and follow-up Lp(a) levels were measured in 915 of the 1039 SATURN participants, and were correlated with changes in percent atheroma volume (ΔPAV). Mean age was 57.7 ± 8.6 years, 74% were men, 96% were Caucasian, with statin use prior to study enrolment occurring in 59.3% of participants. Baseline [median (IQR)] LDL-cholesterol (LDL-C) and measured Lp(a) levels (mg/dL) were 114 (99, 137) and 17.4 (7.6, 52.9) respectively; follow-up measures were 60 (47, 77), and 16.5 (6.7, 57.7) (change from baseline: p < 0.001, p = 0.31 respectively). At baseline, there were 676 patients with Lp(a) levels <50 mg/dL [median Lp(a) of 10.9 mg/dL], and 239 patients with Lp(a) levels ≥ 50 mg/dL [median Lp(a) of 83.2 mg/dL]. Quartiles of baseline and follow-up Lp(a) did not associate with ΔPAV. Irrespective of the achieved LDL-C ( 50 mg/dL. In coronary artery disease patients prescribed long-term maximally intensive statin therapy with low on-treatment LDL-C levels, measured Lp(a) levels (predominantly below the 50 mg/dL threshold) do not associate with coronary atheroma progression. Alternative biomarkers may thus associate with residual cardiovascular risk in such patients. Copyright © 2017 Elsevier B.V. All rights reserved.

Recycling, Remobilization, and Eruption of Crystals from the Lassen Volcanic Center

NASA Astrophysics Data System (ADS)

Schrecengost, K.; Cooper, K. M.; Kent, A. J.; Huber, C.; Clynne, M. A.

2016-12-01

The Lassen Volcanic Center recently produced two relatively small dacitic eruptions (0.03 km3 -1.4 km3) with a complex mixing history. Preliminary data for the 1915 Lassen Peak (LP) and the 1103±13 ybp Chaos Crags (CC) eruptions indicate complex mixing between a remobilized crystal mush (hornblende, biotite, sodic plagioclase, quartz) and basalt or basaltic andesite. U-series bulk ages represent crystallization of plagioclase at an average age of either a single event or a mixture of different plagioclase populations that crystallized during distinct crystallization events separated in time. We present 238U-230Th disequilibria for the LP light dacite and black dacite along with three stages (upper pyroclastic flow deposit, Dome B, and Dome F) of the CC eruption. Initial 230Th/232Th activity ratios for the LP plagioclase are higher than the LP host liquid and modeled equilibrium zero-age plagioclase towards the CC host liquid composition. The LP plagioclase data are inconsistent with crystallization from the LP host liquid. Therefore, at least a portion of the plagioclase carried by the LP eruptive products are antecrystic originating from an older and/or isotopically distinct host liquid composition. Moreover, LP bulk plagioclase is consistent with crystallization from the CC host liquid, suggesting that both eruptions are sourced from a similar host reservoir (i.e., crystal mush). Hornblende and biotite from the LP eruption have isotopic ratios that are consistent with zero age crystallization from the LP liquid composition, suggesting that they are younger and originate from a different magma than the plagioclase, with mixing between the magmas prior to eruption. However, it is more likely that hornblende, biotite, and plagioclase with varying average crystal ages were remobilized and erupted from a common crystal mush reservoir during the LP and CC eruptions. These data are consistent with zircon 238U-230Th model ages [1] that emphasize the importance of local, small-scale rejuvenation and mixing within a long-lived magmatic system. Moreover, assuming crystallization from a CC-like liquid compositions, LP bulk plagioclase model ages produce similar ages to those derived from LP and CC zircon (i.e., 17 ka to secular equilibrium). [1] Klemetti and Clynne, PLoS ONE, 9(12): e113157.

76 FR 76802 - Riverside Micro-Cap Fund II, L.P.; Notice Seeking Exemption Under Section 312 of the Small...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-08

... SMALL BUSINESS ADMINISTRATION [License No. 02/02-0646] Riverside Micro-Cap Fund II, L.P.; Notice... hereby given that Riverside Micro-Cap Fund II, L.P., 45 Rockefeller Center, New York, NY 10111, a Federal... Regulations (13 CFR 107.730). Riverside Micro-Cap Fund II, L.P. proposes to provide equity security financing...

77 FR 7655 - Riverside Micro-Cap Fund II, L.P.; Notice Seeking Exemption Under Section 312 of the Small...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-13

... SMALL BUSINESS ADMINISTRATION [License No. 02/02-0646] Riverside Micro-Cap Fund II, L.P.; Notice... hereby given that Riverside Micro-Cap Fund II, L.P., 45 Rockefeller Center, New York, NY 10111, a Federal... Regulations (13 CFR 107.730). Riverside Micro-Cap Fund II, L.P. proposes to provide equity security financing...

75 FR 51451 - Erie Boulevard Hydropower, L.P.; Notice of Intent To File License Application, Filing of Pre...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-20

... Hydropower, L.P.; Notice of Intent To File License Application, Filing of Pre-Application Document, and.... Project No.: 7320-040. c. Dated Filed: June 29, 2010. d. Submitted By: Erie Boulevard Hydropower, L.P. e...: John Mudre at (202) 502-8902; or e-mail at [email protected] . j. Erie Boulevard Hydropower, L.P...

78 FR 21491 - DeltaPoint Capital IV, L.P., DeltaPoint Capital IV (New York), L.P.; Notice Seeking Exemption...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-10

... Small Business Investment Act of 1958, as amended (``the Act''), in connection with the financing of a... SMALL BUSINESS ADMINISTRATION [License No. 02/02-0662, 02/02-0661] DeltaPoint Capital IV, L.P., DeltaPoint Capital IV (New York), L.P.; Notice Seeking Exemption Under Section 312 of the Small Business...

The role of indoleamine 2,3-dioxygenase in LP-BPM5 murine retroviral disease progression

PubMed Central

2013-01-01

Background Indoleamine 2,3-dioxygenase (IDO) is an immunomodulatory intracellular enzyme involved in tryptophan degradation. IDO is induced during cancer and microbial infections by cytokines, ligation of co-stimulatory molecules and/or activation of pattern recognition receptors, ultimately leading to modulation of the immune response. LP-BM5 murine retroviral infection induces murine AIDS (MAIDS), which is characterized by profound and broad immunosuppression of T- and B-cell responses. Our lab has previously described multiple mechanisms regulating the development of immunodeficiency of LP-BM5-induced disease, including Programmed Death 1 (PD-1), IL-10, and T-regulatory (Treg) cells. Immunosuppressive roles of IDO have been demonstrated in other retroviral models, suggesting a possible role for IDO during LP-BM5-induced retroviral disease progression and/or development of viral load. Methods Mice deficient in IDO (B6.IDO−/−) and wildtype C57BL/6 (B6) mice were infected with LP-BM5 murine retrovirus. MAIDS and LP-BM5 viral load were assessed at termination. Results As expected, IDO was un-inducible in B6.IDO−/− during LP-BM5 infection. B6.IDO−/− mice infected with LP-BM5 retrovirus succumbed to MAIDS as indicated by splenomegaly, serum hyper IgG2a and IgM, decreased responsiveness to B- and T-cell mitogens, conversion of a proportion of CD4+ T cells from Thy1.2+ to Thy1.2-, and increased percentages of CD11b+Gr-1+ cells. LP-BM5 infected B6.IDO−/− mice also demonstrated the development of roughly equivalent disease kinetics as compared to infected B6 mice. Splenic viral loads of B6 and B6.IDO−/− mice were also equivalent after infection as measured by LP-BM5-specific Def Gag and Eco Gag viral mRNA, determined by qRT-PCR. Conclusions Collectively, these results demonstrate IDO neither plays an essential role, nor is required, in LP-BM5-induced disease progression or LP-BM5 viral load. PMID:23680027

Increased risk of coronary artery calcification progression in subjects with high baseline Lp(a) levels: The Kangbuk Samsung Health Study.

PubMed

Cho, Jung Hwan; Lee, Da Young; Lee, Eun Seo; Kim, Jihyun; Park, Se Eun; Park, Cheol-Young; Lee, Won-Young; Oh, Ki-Won; Park, Sung-Woo; Rhee, Eun-Jung

2016-11-01

Results from previous studies support the association of lipoprotein(a) [Lp(a)] levels and coronary artery disease risk. In this study, we analyzed the association between baseline Lp(a) levels and future progression of coronary artery calcification (CAC) in apparently healthy Korean adults. A total of 2611 participants (mean age: 41years, 92% mend) who underwent a routine health check-up in 2010 and 2014 were enrolled. Coronary artery calcium score (CACS) were measured by multi-detector computed tomography. Baseline Lp(a) was measured by high-sensitivity immunoturbidimetric assay. Progression of CAC was defined as a change in CACS >0 over four years. Bivariate correlation analyses with baseline Lp(a) and other metabolic parameters revealed age, total cholesterol, HDL-C, LDL-C and CACS to have a significant positive correlation, while body weight, fasting glucose level, blood pressure and triglyceride level were negatively correlated with baseline Lp(a) level. After four years of follow-up, 635 subjects (24.3%) had CAC progression. The participants who had CAC progression were older, composed of more men, more obese, and had higher fasting glucose levels and worse baseline lipid profiles compared to those who did not have CAC progression. The mean serum Lp(a) level was significantly higher in subjects who had CAC progression compared to those who did not (32.5 vs. 28.9mg/dL, p<0.01). When the risk for CAC progression according to baseline Lp(a) was calculated, those with Lp(a) level≥50mg/dL had an odds ratio of 1.333 (95% CI 1.027-1.730) for CAC progression compared to those with Lp(a)<50mg/dL after adjusting for confounding factors. In this study, the subjects who had higher Lp(a) were at significantly higher risk for CAC progression after four years of follow-up, suggesting the role of high Lp(a) in CAC progression. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Hybrid propulsion technology program. Volume 2: Technology definition package

NASA Technical Reports Server (NTRS)

Jensen, Gordon E.; Holzman, Allen L.; Leisch, Steven O.; Keilbach, Joseph; Parsley, Randy; Humphrey, John

1989-01-01

A concept design study was performed to configure two sizes of hybrid boosters; one which duplicates the advanced shuttle rocket motor vacuum thrust time curve and a smaller, quarter thrust level booster. Two sizes of hybrid boosters were configured for either pump-fed or pressure-fed oxygen feed systems. Performance analyses show improved payload capability relative to a solid propellant booster. Size optimization and fuel safety considerations resulted in a 4.57 m (180 inch) diameter large booster with an inert hydrocarbon fuel. The preferred diameter for the quarter thrust level booster is 2.53 m (96 inches). The demonstration plan would culminate with test firings of a 3.05 m (120 inch) diameter hybrid booster.

7. SOUTHEASTERN VIEW TOWARD THE COMPRESSOR END OF TWO ALLISCHALMER ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. SOUTHEASTERN VIEW TOWARD THE COMPRESSOR END OF TWO ALLIS-CHALMER AXIAL AIR COMPRESSORS IN THE LOW PURITY BULK OXYGEN BUILDING. - U.S. Steel Duquesne Works, Fuel & Utilities Plant, Along Monongahela River, Duquesne, Allegheny County, PA

Conceptual Design of a Two Spool Compressor for the NASA Large Civil Tilt Rotor Engine

NASA Technical Reports Server (NTRS)

Veres, Joseph P.; Thurman, Douglas R.

2010-01-01

This paper focuses on the conceptual design of a two spool compressor for the NASA Large Civil Tilt Rotor engine, which has a design-point pressure ratio goal of 30:1 and an inlet weight flow of 30.0 lbm/sec. The compressor notional design requirements of pressure ratio and low-pressure compressor (LPC) and high pressure ratio compressor (HPC) work split were based on a previous engine system study to meet the mission requirements of the NASA Subsonic Rotary Wing Projects Large Civil Tilt Rotor vehicle concept. Three mean line compressor design and flow analysis codes were utilized for the conceptual design of a two-spool compressor configuration. This study assesses the technical challenges of design for various compressor configuration options to meet the given engine cycle results. In the process of sizing, the technical challenges of the compressor became apparent as the aerodynamics were taken into consideration. Mechanical constraints were considered in the study such as maximum rotor tip speeds and conceptual sizing of rotor disks and shafts. The rotor clearance-to-span ratio in the last stage of the LPC is 1.5% and in the last stage of the HPC is 2.8%. Four different configurations to meet the HPC requirements were studied, ranging from a single stage centrifugal, two axi-centrifugals, and all axial stages. Challenges of the HPC design include the high temperature (1,560deg R) at the exit which could limit the maximum allowable peripheral tip speed for centrifugals, and is dependent on material selection. The mean line design also resulted in the definition of the flow path geometry of the axial and centrifugal compressor stages, rotor and stator vane angles, velocity components, and flow conditions at the leading and trailing edges of each blade row at the hub, mean and tip. A mean line compressor analysis code was used to estimate the compressor performance maps at off-design speeds and to determine the required variable geometry reset schedules of the inlet guide vane and variable stators that would result in the transonic stages being aerodynamically matched with high efficiency and acceptable stall margins based on user specified maximum levels of rotor diffusion factor and relative velocity ratio.

Continuation of SAGE and MLS High-Resolution Ozone Profiles with the Suomi NPP OMPS Limb Profiler

NASA Astrophysics Data System (ADS)

Kramarova, N. A.; Bhartia, P. K.; Moy, L.; Chen, Z.; Frith, S. M.

2015-12-01

The Ozone Mapper and Profiler Suite (OMPS) Limb Profiler (LP) onboard the Suomi NPP satellite is design to measure ozone profiles with a high vertical resolution (~2 km) and dense spatial sampling (~1° latitude). The LP sensor represents a new generation of the US ozone profile instruments with the plan for a follow-up limb instrument onboard the Joint Polar Satellite System 2 (JPSS-2) in 2021. In this study we will examine the suitability of using LP profiles to continue the EOS climate ozone profile record from the SAGE and MLS datasets. First of all, we evaluate the accuracy in determining the LP tangent height by analyzing measured and calculated radiances. The accurate estimation of the tangent height is critical for limb observations. Several methods were explored to estimate the uncertainties in the LP tangent height registration, and the results will be briefly summarized in this presentation. Version 2 of LP data, released in May 2014, includes a static adjustment of ~1.5 km and a dynamic tangent height adjustment within each orbit. A recent analysis of Version 2 Level 1 radiances revealed a 100 m step in the tangent height that occurred on 26 April 2013, due to a switch to two star trackers in determining spacecraft position. In addition, a ~200 m shift in the tangent height along each orbit was detected. These uncertainties in tangent height registrations can affect the stability of the LP ozone record. Therefore, the second step in our study includes a validation of LP ozone profiles against correlative satellite ozone measurements (Aura MLS, ACE-FTS, OSIRIS, and SBUV) with the focus on time-dependent changes. We estimate relative drifts between OMPS LP and correlative ozone records to evaluate stability of the LP measurements. We also test the tangent height corrections found in the internal analysis of Version 2 measurements to determine their effect on the long-term stability of the LP ozone record.

Significance of lipoprotein(a) levels in familial hypercholesterolemia and coronary artery disease.

PubMed

Li, Sha; Wu, Na-Qiong; Zhu, Cheng-Gang; Zhang, Yan; Guo, Yuan-Lin; Gao, Ying; Li, Xiao-Lin; Qing, Ping; Cui, Chuan-Jue; Xu, Rui-Xia; Sun, Jing; Liu, Geng; Dong, Qian; Li, Jian-Jun

2017-05-01

Patients with familial hypercholesterolemia (FH) are often characterized by premature coronary artery disease (CAD) with heterogeneity at onset. The aim of the present study was to investigate the associations of lipoprotein (a) [Lp(a)] with the FH phenotype, genotype and roles of Lp(a) in determining CAD risk among patients with and without FH. We enrolled 8050 patients undergoing coronary angiography, from our Lipid clinic. Clinical FH was diagnosed using the Dutch Lipid Clinic Network criteria. Mutational analysis (LDLR, APOB, PCSK9) in definite/probable FH was performed by target exome sequencing. Lp(a) levels were increased, with a clinical FH diagnosis (unlikely, possible, definite/probable FH) independent of the patients status, with Lp(a)-hyperlipoproteinemia [Lp(a)-HLP] (median 517.70 vs. 570.98 vs. 604.65 mg/L, p < 0.001) or without (median 89.20 vs. 99.20 vs. 133.67 mg/L, p < 0.001). Patients with Lp(a)-HLP had a higher prevalence of definite/probable FH than those without (6.1% vs. 2.4%, p < 0.05). However, no significant difference in Lp(a) was observed in patients with definite/probable FH phenotype carrying LDLR or LDLR-independent (APOB, PCSK9) or neither mutations (p > 0.05). Multivariate analysis showed that Lp(a) and FH phenotype were both significant determinants in predicting the early onset and severity of CAD. Subsequently, patients with Lp(a)-HLP in definite/probable FH increased significantly the CAD risk (all p < 0.05). Lp(a) levels were higher in patients with FH phenotype than in those without, but no difference were found in FH patients of different mutated backgrounds. Moreover, Lp(a) and FH played a synergistic role in predicting the early onset and severity of CAD. Copyright © 2017 Elsevier B.V. All rights reserved.

Parental and Volunteer Perception of Pyloromyotomy Scars: Comparing Laparoscopic, Open, and Nonsurgical Volunteers.

PubMed

St Peter, Shawn D; Acher, Charles W; Shah, Sohail R; Sharp, Susan W; Ostlie, Daniel J

2016-04-01

Despite evidence from prospective trials and meta-analyses supporting laparoscopic pyloromyotomy (LP) over open pyloromyotomy (OP), the open technique is still utilized by some surgeons on the premise that there is minimal clinical benefit to LP over OP. Although the potential cosmetic benefit of LP over OP is often cited in reports, it has never been objectively evaluated. After internal review board approval, the parents of patients from a previous prospective trial who had undergone LP (n = 9) and OP (n = 10) were contacted. After consent was obtained, the parents and patients were asked to complete a validated scar scoring questionnaire that was compared between groups. Standardized photos were taken of study subjects and controls with no abdominal procedures. Blinded volunteers were recruited to view the photos, identify if scars were present, and complete questions if a scar(s) was seen. Volunteers were also asked about the degree of satisfaction if their child had similar scars on a four-point scale from happy to unacceptable. Mean age was 7 years in both groups. Parental scar assessment scores were superior in the LP group in every category. Blinded volunteers detected abdominal scars significantly more often in the OP group (98%) vs. the LP group (28%; P < .001). The volunteers detected a scar in 16% of the controls, comparable to the 28% detected in the LP group (P = .17). The degree of satisfaction estimate by volunteers was 1.78 for OP and 1.02 for LP and controls, generating a Cohen's d effect size of 5.1 standard deviation units comparing OP to either LP or controls (very large ≥1.3). Parents of children scored LP scars superior to OP scars. Surgical scars are almost always identifiable with OP while the surgical scars associated with LP approach invisibility to the observer, appearing similar to patients with no prior abdominal operation.

Do root hydraulic properties change during the early vegetative stage of plant development in barley (Hordeum vulgare)?

PubMed

Suku, Shimi; Knipfer, Thorsten; Fricke, Wieland

2014-02-01

As annual crops develop, transpirational water loss increases substantially. This increase has to be matched by an increase in water uptake through the root system. The aim of this study was to assess the contributions of changes in intrinsic root hydraulic conductivity (Lp, water uptake per unit root surface area, driving force and time), driving force and root surface area to developmental increases in root water uptake. Hydroponically grown barley plants were analysed during four windows of their vegetative stage of development, when they were 9-13, 14-18, 19-23 and 24-28 d old. Hydraulic conductivity was determined for individual roots (Lp) and for entire root systems (Lp(r)). Osmotic Lp of individual seminal and adventitious roots and osmotic Lp(r) of the root system were determined in exudation experiments. Hydrostatic Lp of individual roots was determined by root pressure probe analyses, and hydrostatic Lp(r) of the root system was derived from analyses of transpiring plants. Although osmotic and hydrostatic Lp and Lp(r) values increased initially during development and were correlated positively with plant transpiration rate, their overall developmental increases (about 2-fold) were small compared with increases in transpirational water loss and root surface area (about 10- to 40-fold). The water potential gradient driving water uptake in transpiring plants more than doubled during development, and potentially contributed to the increases in plant water flow. Osmotic Lp(r) of entire root systems and hydrostatic Lp(r) of transpiring plants were similar, suggesting that the main radial transport path in roots was the cell-to-cell path at all developmental stages. Increase in the surface area of root system, and not changes in intrinsic root hydraulic properties, is the main means through which barley plants grown hydroponically sustain an increase in transpirational water loss during their vegetative development.

One-year neurodevelopmental outcome of very and late preterm infants: Risk factors and correlation with maternal stress.

PubMed

Coletti, Maria Franca; Caravale, Barbara; Gasparini, Corinna; Franco, Francesco; Campi, Francesca; Dotta, Andrea

2015-05-01

Although "late preterm" (LP) newborns (33-36 weeks of gestational age) represent more than 70% of all preterm labors, little is known about the relation between certain risk factors and developmental outcomes in LP compared to "very preterm" (≤32 weeks) children (VP). This study investigates: (1) LP and VP infants' development at 12 months of corrected age (CA) using the Bayley Scales of Infant Development - 3rd Edition (BSID-III); (2) correlation between BSID-III performances and maternal stress (using Parenting Stress Index-Short Form, PSI-SF) among LP and VP at 12 months CA; and (3) the link between known neonatal and demographic risk factors and developmental outcomes of LP and VP infants. For both LP and VP infants the Mean Cognitive (LP: 102.69±7.68; VP: 103.63±10.68), Language (LP: 96.23±10.08; VP: 99.10±10.37) and Motor (LP: 91.11±10.33; VP: 93.85±10.17) composite scores were in the normal range, without significant differences between the groups. Correlations between PSI-SF and BSID-III showed that in the VP group (but not LP), Language score was negatively related to the PSI-SF 'Difficult Child' scale (r=-.34, p<.05). Regression models revealed that cognitive performance was significantly predicted by physical therapy in LP and by cesarean section in VP infants. For VP only maternal education and length of stay predicted Language score, whereas physical therapy predicted Motor score. Results of the study underline the importance of considering cognitive, language and motor developments separately when assessing a preterm child's development. Prediction models of developmental performance confirm the influence of some known neonatal risk factors and indicate the need for further research on the role of sociodemographic risk factors. Copyright © 2015 Elsevier Inc. All rights reserved.

Leukoproliferative response of splenocytes from English sole (Pleuronectes vetulus) exposed to chemical contaminants

DOE Office of Scientific and Technical Information (OSTI.GOV)

Arkoosh, M.R.; Clemons, E.; Huffman, P.

The leukoproliferative (LP) response of splenic leukocytes from the marine benthic fish English sole (Pleuronectes vetulus) stimulated with the mitogens lipopolysaccharide (LPS), convanavalin A (Con A), and pokeweed mitogen (PWM) was examined as a biomarker of immunotoxic effects. English sole were exposed to contaminants, either by injection of an organic-solvent extract of a sediment containing polycyclic aromatic compounds (PACs) or placed for up to 5 weeks on a reference sediment containing 0.15 to 1.5% (v/v) of the PAC-contaminated sediment. English sole either injected with the contaminated extract or held on PAC-contaminated sediment had an augmented response to Con A. Themore » LP response to LPS showed no relationship to PAC exposure in laboratory-exposed fish, while PWM showed no consistent relationship to exposure to PACs. In a field study, English sole captured from an urban area in Puget Sound, Washington, USA, contaminated with PACs and other chemical contaminants had a significantly augmented LP response to Con A and PWM in comparison to the LP response in fish from a nonurban reference site. Fish from another nonurban site also had an augmented LP response to Con A, indicating that the elevation of the Con A LP response can also result from factors other than chemical contaminant exposure. In addition, English sole from this site also had an augmented LP response to LPS, whereas fish from urban sites did not exhibit an augmented LP response to LPS. Overall, the results demonstrated that although the LP response in splenic leukocytes of English sole to Con A was linked to contaminant exposure, the LP response to Con A did not exhibit high specificity as an indicator of chemical contaminant exposure. However, the concerted use of Con A, LPS, and PWM allowed for identification of apparent chemical contaminant-induced alterations of the LP response in English sole from an urban area of Puget Sound.« less

Lipoprotein (a), metabolic syndrome and coronary calcium score in a large occupational cohort.

PubMed

Sung, K-C; Wild, S H; Byrne, C D

2013-12-01

Whether lipoprotein (a) [Lp(a)] concentration is associated with metabolic syndrome (MetS) and pre-clinical atherosclerosis in different ethnic groups is uncertain. The association between Lp(a), MetS and a measure of pre-clinical atherosclerosis was studied in a large Asian cohort. Data were analyzed from a South Korean occupational cohort who underwent a cardiac computed tomography (CT) estimation of CAC score and measurements of cardiovascular risk factors (n = 14,583 people). The key exposure was an Lp(a) concentration in the top quartile (>38.64 mg/dL)) with a CAC score >0 as the outcome variable and measure of pre-clinical atherosclerosis. Logistic regression was used to describe the associations. 1462 participants had a CAC score >0. In the lowest Lp(a) quartile (<11.29 mg/dL), 25.8% had MetS, compared with 16.1% in the highest Lp(a) quartile (>38.64 mg/dL (p < 0.001). MetS, and component features, were inversely related to Lp(a) concentration (all p < 0.0001). In the highest Lp(a) quartile group, there was an association between Lp(a) and CAC score >0 in men (OR 1.21[1.05, 1.40], p = 0.008), and women (OR 1.62[1.03, 2.55], p = 0.038), after adjustment for age, sex, lipid lowering therapy, and multiple cardiovascular risk factors. There was no evidence of an interaction between highest quartile Lp(a) and either high LDLc (>147 mg/dL) (p = 0.99), or MetS (p = 0.84) on the association with CAC score >0. Lp(a) levels are inversely related to MetS and its components. There was a robust association between Lp(a) concentration >38.6 mg/dL and marker of early atherosclerosis in both men and women, regardless of LDLc, level MetS or other cardiovascular risk factors. © 2013 Elsevier B.V. All rights reserved.

Design and Development of a Novel Knudsen Compressor as a Part of a Joule-Thomson Cryocooler

NASA Astrophysics Data System (ADS)

Muthuvijayan, Indra; Antelius, Mikael; Björneklett, Are; Nilsson, Peter; Thorslund, Robert

2017-11-01

This paper presents the design and development of a novel Knudsen compressor, with no moving parts, as a part of a Joule-Thomson cryocooler. The compressor works by using the Knudsen diffusion principle and includes a combination of graphene-based layers and Knudsen membranes in a particular fashion to pressurize the fluid. The Knudsen membrane for this application was selected by testing several commercially available materials. Prototypes of single stage and a multistage compressors are presented together with experimental evaluations. Insights on a Tube-in-Tube heat exchanger, as another part a the Joule-Thomson cryocooler, intended to integrate with the Knudsen compressor, are also presented.

High Efficiency Centrifugal Compressor for Rotorcraft Applications

NASA Technical Reports Server (NTRS)

Medic, Gorazd; Sharma, Om P.; Jongwook, Joo; Hardin, Larry W.; McCormick, Duane C.; Cousins, William T.; Lurie, Elizabeth A.; Shabbir, Aamir; Holley, Brian M.; Van Slooten, Paul R.

2017-01-01

A centrifugal compressor research effort conducted by United Technologies Research Center under NASA Research Announcement NNC08CB03C is documented. The objectives were to identify key technical barriers to advancing the aerodynamic performance of high-efficiency, high work factor, compact centrifugal compressor aft-stages for turboshaft engines; to acquire measurements needed to overcome the technical barriers and inform future designs; to design, fabricate, and test a new research compressor in which to acquire the requisite flow field data. A new High-Efficiency Centrifugal Compressor stage -- splittered impeller, splittered diffuser, 90 degree bend, and exit guide vanes -- with aerodynamically aggressive performance and configuration (compactness) goals were designed, fabricated, and subquently tested at the NASA Glenn Research Center.

Effect of design over-all compressor pressure ratio division on acceleration characteristics of three hypothetical two-spool turbojet engines

NASA Technical Reports Server (NTRS)

Filippi, Richard E; Dugan, James F , Jr

1956-01-01

The engines, each with a compressor overall total-pressure ratio of 12 and a design inner-turbine-inlet temperature of 2500 degrees R, were investigated at static sea-level conditions to determine the effect on transient performance of varying the desitn pressure ratio divisions 2-6, 3-4, and 4-3 between the outer and inner compressors. The transient considered was an acceleration from 40 to 100 percent design thrust. When the outer compressor of each engine reached design speed, the inner compressors were overspeeding, the maximum being only 1.7 over design mechanical speed. Acceleration times for the three engines were equal.

Method and apparatus for starting supersonic compressors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lawlor, Shawn P

A supersonic gas compressor with bleed gas collectors, and a method of starting the compressor. The compressor includes aerodynamic duct(s) situated for rotary movement in a casing. The aerodynamic duct(s) generate a plurality of oblique shock waves for efficiently compressing a gas at supersonic conditions. A convergent inlet is provided adjacent to a bleed gas collector, and during startup of the compressor, bypass gas is removed from the convergent inlet via the bleed gas collector, to enable supersonic shock stabilization. Once the oblique shocks are stabilized at a selected inlet relative Mach number and pressure ratio, the bleed of bypassmore » gas from the convergent inlet via the bypass gas collectors is effectively eliminated.« less

Performance of NACA Eight-stage Axial-flow Compressor Designed on the Basis of Airfoil Theory

NASA Technical Reports Server (NTRS)

Sinnette, John T; Schey, Oscar W; King, J Austin

1943-01-01

The NACA has conducted an investigation to determine the performance that can be obtained from a multistage axial-flow compressor based on airfoil research. A theory was developed; an eight-stage axial-flow compressor was designed, constructed, and tested. The performance of the compressor was determined for speeds from 5000 to 14,000 r.p.m with varying air flow at each speed. Most of the tests were made with air at room temperature. The performance was determined in accordance with the Committee's recommended procedure for testing superchargers. The expected performance was obtained, showing that a multistage compressor of high efficiency can be designed by the application of airfoil theory.

47 CFR 73.3500 - Application and report forms.

Code of Federal Regulations, 2014 CFR

2014-10-01

..., TV Translator or TV Booster Station. 347 Application for a Low Power TV, TV Translator or TV Booster... Booster Station. 350 Application for an FM Translator or FM Booster Station License. 395-B Annual...

47 CFR 73.3500 - Application and report forms.

Code of Federal Regulations, 2012 CFR

2012-10-01

..., TV Translator or TV Booster Station. 347 Application for a Low Power TV, TV Translator or TV Booster... Booster Station. 350 Application for an FM Translator or FM Booster Station License. 395-B Annual...

47 CFR 73.3500 - Application and report forms.

Code of Federal Regulations, 2011 CFR

2011-10-01

..., TV Translator or TV Booster Station. 347 Application for a Low Power TV, TV Translator or TV Booster... Booster Station. 350 Application for an FM Translator or FM Booster Station License. 395-B Annual...

47 CFR 73.3500 - Application and report forms.

Code of Federal Regulations, 2013 CFR

2013-10-01

..., TV Translator or TV Booster Station. 347 Application for a Low Power TV, TV Translator or TV Booster... Booster Station. 350 Application for an FM Translator or FM Booster Station License. 395-B Annual...

Long-term statin therapy could be efficacious in reducing the lipoprotein (a) levels in patients with coronary artery disease modified by some traditional risk factors.

PubMed

Xu, Ming-Xing; Liu, Chang; He, Yong-Ming; Yang, Xiang-Jun; Zhao, Xin

2017-05-01

Lipoprotein (a) [Lp (a)] is a well-established risk factor for coronary artery disease (CAD). However, up till now, treatment of patients with higher Lp (a) levels is challenging. This current study aimed to investigate the therapeutic effects of short-, medium and long-term statin use on the Lp (a) reduction and its modifying factors. The therapeutic duration was categorized into short-term (median, 39 days), medium term (median, 219 days) and long-term (median, 677 days). The lipid profiles before therapy served as baselines. Patients at short-, medium or long-term exactly matched with those at baseline. Every patient's lipid profiles during the follow-ups were compared to his own ones at baselines. The current study demonstrated that long-term statin therapy significantly decreased the Lp (a) levels in CAD patients while short-term or medium term statin therapy didn't. When grouped by statin use, only long-term simvastatin use significantly decreased the Lp (a) levels while long-term atorvastatin use insignificantly decreased the Lp (a) levels. Primary hypertension (PH), DM, low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) could modify the therapeutic effects of statin use on the Lp (a) levels in CAD patients. The long-term statin therapy could be efficacious in reducing the Lp (a) levels in CAD patients, which has been modified by some traditional risk factors. In the era of commercial unavailability of more reliable Lp (a) lowering drugs, our findings will bolster confidence in fighting higher Lp (a) abnormalities both for patients and for doctors.

Effect of woody-plant encroachment on livestock production in North and South America

PubMed Central

Anadón, José D.; Sala, Osvaldo E.; Turner, B. L.; Bennett, Elena M.

2014-01-01

A large fraction of the world grasslands and savannas are undergoing a rapid shift from herbaceous to woody-plant dominance. This land-cover change is expected to lead to a loss in livestock production (LP), but the impacts of woody-plant encroachment on this crucial ecosystem service have not been assessed. We evaluate how tree cover (TC) has affected LP at large spatial scales in rangelands of contrasting social–economic characteristics in the United States and Argentina. Our models indicate that in areas of high productivity, a 1% increase in TC results in a reduction in LP ranging from 0.6 to 1.6 reproductive cows (Rc) per km2. Mean LP in the United States is 27 Rc per km2, so a 1% increase in TC results in a 2.5% decrease in mean LP. This effect is large considering that woody-plant cover has been described as increasing at 0.5% to 2% per y. On the contrary, in areas of low productivity, increased TC had a positive effect on LP. Our results also show that ecological factors account for a larger fraction of LP variability in Argentinean than in US rangelands. Differences in the relative importance of ecological versus nonecological drivers of LP in Argentina and the United States suggest that the valuation of ecosystem services between these two rangelands might be different. Current management strategies in Argentina are likely designed to maximize LP for various reasons we are unable to explore in this effort, whereas land managers in the United States may be optimizing multiple ecosystem services, including conservation or recreation, alongside LP. PMID:25136084

Impact of high lipoprotein(a) levels on in-stent restenosis and long-term clinical outcomes of angina pectoris patients undergoing percutaneous coronary intervention with drug-eluting stents in Asian population.

PubMed

Park, Sang-Ho; Rha, Seung-Woon; Choi, Byoung-Geol; Park, Ji-Young; Jeon, Ung; Seo, Hong-Seog; Kim, Eung-Ju; Na, Jin-Oh; Choi, Cheol-Ung; Kim, Jin-Won; Lim, Hong-Euy; Park, Chang-Gyu; Oh, Dong-Joo

2015-06-01

Lipoprotein(a) (Lp(a)) is known to be associated with cardiovascular complications and atherothrombotic properties in general populations. However, it has not been examined whether Lp(a) levels are able to predict adverse cardiovascular outcomes in patients undergoing percutaneous coronary intervention (PCI) with drug-eluting stents (DES). A total of 595 consecutive patients with angina pectoris who underwent elective PCI with DES were enrolled from 2004 to 2010. The patients were divided into two groups according to the levels of Lp(a): Lp(a) < 50 mg/dL (n = 485 patients), and Lp(a) ≥ 50 mg/dL (n = 111 patients). The 6-9-month angiographic outcomes and 3-year cumulative major clinical outcomes were compared between the two groups. Binary restenosis occurred in 26 of 133 lesions (19.8%) in the high Lp(a) group and 43 of 550 lesions (7.9%) in the low Lp(a) group (P = 0.001). In multivariate analysis, the reference vessel diameter, low density lipoprotein cholesterol, total lesion length, and Lp(a) ≥ 50 mg/dL were predictors of binary restenosis. In the Cox proportional hazards regression analysis, Lp(a) > 50 mg/dL was significantly associated with the 3-year adverse clinical outcomes including any myocardial infarction, revascularization (target lesion revascularization (TLR) and target vessel revascularization (TVR)), TLR-major adverse cardiac events (MACEs), TVR-MACE, and All-MACEs. In our study, high Lp(a) level ≥ 50 mg/dL in angina pectoris patients undergoing elective PCI with DES was significantly associated with binary restenosis and 3-year adverse clinical outcomes in an Asian population. © 2015 Wiley Publishing Asia Pty Ltd.

Ischemic Effects of Transcatheter Arterial Embolization with N-Butyl Cyanoacrylate-Lipiodol on the Colon in a Swine Model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ikoma, Akira; Kawai, Nobuyuki; Sato, Morio, E-mail: morisato@wakayama-med.ac.jp

2010-10-15

This study was designed to assess the safety of transcatheter arterial embolization (TAE) with n-butyl cyanoacrylate-lipiodol (NBCA-Lp) for the large bowel and to investigate the vital response to NBCA-Lp in a swine model. In nine swine, nine arteries nourishing the colon were embolized with NBCA-Lp (1 ml of NBCA mixed with 4 ml of lipiodol): sigmoid-rectal branch artery in six swine, right colic branch artery in two, and middle colic branch artery in one. The amount of NBCA-Lp was 0.1-0.4 ml. Sacrifice was conducted 3 days after TAE to identify histological infarction. Classification was conducted retrospectively: group A, vasa rectamore » without NBCA-Lp embolization despite TAE; group B, three or fewer vasa recta with NBCA-Lp embolization; and group C, five or more vasa recta with NBCA-Lp embolization. In one swine in group A, no necrotic focus was observed. In group B, three of four swine experienced no ischemic damage. The remaining one swine experienced necrosis of mucosal and submucosal layers in one-fourth of the circumference. In group C, all four swine with marginal artery and five vasa recta or more embolized experienced total necrosis of mucosa, submucosa, and smooth muscle layers of the whole colonic circumference. Significant difference on the extent of ischemic damage was observed between groups B and C (P < 0.05). Microscopically, NBCA-Lp induced acute vasculitis. Embolization of three or fewer vasa recta with NBCA-Lp induced no ischemic damage or limited necrosis, whereas embolization of five or more vasa recta with NBCA-Lp induced extensive necrosis.« less

A pentanucleotide repeat polymorphism in the 5' control region of the apolipoprotein(a) gene is associated with lipoprotein(a) plasma concentrations in Caucasians.

PubMed Central

Trommsdorff, M; Köchl, S; Lingenhel, A; Kronenberg, F; Delport, R; Vermaak, H; Lemming, L; Klausen, I C; Faergeman, O; Utermann, G

1995-01-01

The enormous interindividual variation in the plasma concentrations of the atherogenic lipoprotein(a) [Lp(a)] is almost entirely controlled by the apo(a) locus on chromosome 6q26-q27. A variable number of transcribed kringle4 repeats (K4-VNTR) in the gene explains a large fraction of this variation, whereas the rest is presently unexplained. We here have analyzed the effect of the K4-VNTR and of a pentanucleotide repeat polymorphism (TTTTA)n (n = 6-11) in the 5' control region of the apo(a) gene on plasma Lp(a) levels in unrelated healthy Tyroleans (n = 130), Danes (n = 154), and Black South Africans (n = 112). The K4-VNTR had a significant effect on plasma Lp(a) levels in Caucasians and explained 41 and 45% of the variation in Lp(a) plasma concentration in Tyroleans and Danes, respectively. Both, the pentanucleotide repeat (PNR) allele frequencies and their effects on Lp(a) concentrations were heterogeneous among populations. A significant negative correlation between the number of pentanucleotide repeats and the plasma Lp(a) concentration was observed in Tyroleans and Danes. The effect of the 5' PNRP on plasma Lp(a) concentrations was independent from the K4-VNTR and explained from 10 to 14% of the variation in Lp(a) concentrations in Caucasians. No significant effect of the PNRP was present in Black Africans. This suggests allelic association between PNR alleles and sequences affecting Lp(a) levels in Caucasians. Thus, in Caucasians but not in Blacks, concentrations of the atherogenic Lp(a) particle are strongly associated with two repeat polymorphisms in the apo(a) gene. Images PMID:7615785

Factors associated with lipoprotein(a) in chronic kidney disease.

PubMed

Uhlig, Katrin; Wang, Shin-Ru; Beck, Gerald J; Kusek, John W; Marcovina, Santica M; Greene, Tom; Levey, Andrew S; Sarnak, Mark J

2005-01-01

It is unclear whether lipoprotein(a) (Lp[a]) levels in patients with chronic kidney disease (CKD) are elevated as a result of reduced glomerular filtration rate (GFR) or other factors associated with CKD. The goal of this study is to describe the association of Lp(a) level with GFR in the context of apoprotein(a) (apo[a]) isoform size, race, and other kidney disease-related factors, such as proteinuria, serum albumin level, C-reactive protein (CRP) level, and serum lipid levels. Lp(a) and apo(a) isoforms were measured in serum samples obtained at baseline from 804 participants in the Modification of Diet in Renal Disease study (GFR range, 13 to 55 mL/min/1.73 m2). The cross-sectional association between Lp(a) level and GFR, apo(a) isoform size, race, and other variables was analyzed in univariate and multivariate linear regression. Median Lp(a) level was greater in blacks than whites (97.5 versus 28.1 nmol/L; P < 0.001). Those with a low-molecular-weight apo(a) isoform size had greater Lp(a) levels than those with a high-molecular-weight apo(a) isoform size (57.5 versus 21.3 nmol/L; P < 0.001). Lp(a) level was not associated with GFR. Low-molecular-weight apo(a), black race, and greater levels of proteinuria, CRP, and triglycerides were independently associated with greater Lp(a) levels. In this population with CKD stages 3 to 4, GFR was not associated with Lp(a) level, whereas other factors related to CKD, such as proteinuria, CRP level, and triglyceride level, as well as genetic factors such as apo(a) isoform size and race, were associated with Lp(a) level.

Tonic nanomolar dopamine enables an activity-dependent phase recovery mechanism that persistently alters the maximal conductance of the hyperpolarization-activated current in a rhythmically active neuron.

PubMed

Rodgers, Edmund W; Fu, Jing Jing; Krenz, Wulf-Dieter C; Baro, Deborah J

2011-11-09

The phases at which network neurons fire in rhythmic motor outputs are critically important for the proper generation of motor behaviors. The pyloric network in the crustacean stomatogastric ganglion generates a rhythmic motor output wherein neuronal phase relationships are remarkably invariant across individuals and throughout lifetimes. The mechanisms for maintaining these robust phase relationships over the long-term are not well described. Here we show that tonic nanomolar dopamine (DA) acts at type 1 DA receptors (D1Rs) to enable an activity-dependent mechanism that can contribute to phase maintenance in the lateral pyloric (LP) neuron. The LP displays continuous rhythmic bursting. The activity-dependent mechanism was triggered by a prolonged decrease in LP burst duration, and it generated a persistent increase in the maximal conductance (G(max)) of the LP hyperpolarization-activated current (I(h)), but only in the presence of steady-state DA. Interestingly, micromolar DA produces an LP phase advance accompanied by a decrease in LP burst duration that abolishes normal LP network function. During a 1 h application of micromolar DA, LP phase recovered over tens of minutes because, the activity-dependent mechanism enabled by steady-state DA was triggered by the micromolar DA-induced decrease in LP burst duration. Presumably, this mechanism restored normal LP network function. These data suggest steady-state DA may enable homeostatic mechanisms that maintain motor network output during protracted neuromodulation. This DA-enabled, activity-dependent mechanism to preserve phase may be broadly relevant, as diminished dopaminergic tone has recently been shown to reduce I(h) in rhythmically active neurons in the mammalian brain.

Transcriptome analysis of the epidermis of the purple quail-like (q-lp) mutant of silkworm, Bombyx mori.

PubMed

Wang, Pingyang; Qiu, Zhiyong; Xia, Dingguo; Tang, Shunming; Shen, Xingjia; Zhao, Qiaoling

2017-01-01

A new purple quail-like (q-lp) mutant found from the plain silkworm strain 932VR has pigment dots on the epidermis similar to the pigment mutant quail (q). In addition, q-lp mutant larvae are inactive, consume little and grow slowly, with a high death rate and other developmental abnormalities. Pigmentation of the silkworm epidermis consists of melanin, ommochrome and pteridine. Silkworm development is regulated by ecdysone and juvenile hormone. In this study, we performed RNA-Seq on the epidermis of the q-lp mutant in the 4th instar during molting, with 932VR serving as the control. The results showed 515 differentially expressed genes, of which 234 were upregulated and 281 downregulated in q-lp. BLASTGO analysis indicated that the downregulated genes mainly encode protein-binding proteins, membrane components, oxidation/reduction enzymes, and proteolytic enzymes, whereas the upregulated genes largely encode cuticle structural constituents, membrane components, transport related proteins, and protein-binding proteins. Quantitative reverse transcription PCR was used to verify the accuracy of the RNA-Seq data, focusing on key genes for biosynthesis of the three pigments and chitin as well as genes encoding cuticular proteins and several related nuclear receptors, which are thought to play key roles in the q-lp mutant. We drew three conclusions based on the results: 1) melanin, ommochrome and pteridine pigments are all increased in the q-lp mutant; 2) more cuticle proteins are expressed in q-lp than in 932VR, and the number of upregulated cuticular genes is significantly greater than downregulated genes; 3) the downstream pathway regulated by ecdysone is blocked in the q-lp mutant. Our research findings lay the foundation for further research on the developmental changes responsible for the q-lp mutant.

Water Ingestion into Axial Flow Compressors. Part III. Experimental Results and Discussion

DTIC Science & Technology

1981-10-01

total pressure, static pressure, and temperature at both compressor inlet and outlet. A United Sensor model PDC-12-G-l0-KL pitot-static pressure probe...Test Compressor inlet and outlet temperatures during water injection tests: United Sensor and Control Corp. type TK-8-CiA-36’-F Aspirate...ured utilizing standard aspirated thermocouples, namely an United Sensor and Control Corp. type TK-8-C/A-36-F. The Test Compressor out- let

Unsteady Viscous Flow in a High Speed Core Compressor

DTIC Science & Technology

1990-12-01

in a High Speed Core Compressor by M. A. Cherrett DTICJ. D.Bryc ELECTE J. D. Bryce MAR 2 81991 ED Procurement Executive, Ministry of Defence...ESTABLISHMENT Technical Memorandum P 1198 Received for printing 10 December 1990 UNSTEADY VISCOUS FLOW IN A HIGH SPEED CORE COMPRESSOR by M. A. Cherrett J. D...processed in the Compressor," ASME PaperNo 89-GT-24 following manner to determine the periodic (phase-locked Cherrett , MA, 1990, Temperature Error

Method and apparatus for rapid thrust increases in a turbofan engine

NASA Technical Reports Server (NTRS)

Cornett, J. E.; Corley, R. C.; Fraley, T. O.; Saunders, A. A., Jr. (Inventor)

1980-01-01

Upon a landing approach, the normal compressor stator schedule of a fan speed controlled turbofan engine is temporarily varied to substantially close the stators to thereby increase the fuel flow and compressor speed in order to maintain fan speed and thrust. This running of the compressor at an off-design speed substantially reduces the time required to subsequently advance the engine speed to the takeoff thrust level by advancing the throttle and opening the compressor stators.

Experimental Investigation of Trailing Edge Crenulation Effects on Losses in a Compressor Cascade

DTIC Science & Technology

1991-12-01

useful in designing axial flow compressors . Two dimensional flow may not be attainable, and the lack of 2D flow does not invalidate cascade data...Seymour. "Experimental Flow in Two-dimensional Cascades," Aerodynamic Design of Axial Flow Compressors (Revised), edited by Irving A. Johnson and Robert...34Viscous Flow in Two-dimensional Cas- cades," Aerodynamic Design of Axial Flow Compressors (Revised) edited by Irving A. Johnson and Robert 0. Bullock

Stage Effects on Stalling and Recovery of a High-Speed 10-Stage Axial- Flow Compressor

DTIC Science & Technology

1990-06-01

facility C Specific heat of air at constant pressureP Cx Axial velocity DC Direct current DAC Data acquisition computer DCS Design corrected compressor ...was designed to inve3tigate the component performance of an axial -flow compressor while stalling and operating in rotating stall. No attempt was made...Temperatures were measured from a probe configuration similar to the to - pressure design . 68 Table 4.2 Compressor instrumentation RADIAL PROPERTY AXIAL

Sea level static calibration of a compact multimission aircraft propulsion simulator with inlet flow distortion

NASA Technical Reports Server (NTRS)

Won, Mark J.

1990-01-01

Wind tunnel tests of propulsion-integrated aircraft models have identified inlet flow distortion as a major source of compressor airflow measurement error in turbine-powered propulsion simulators. Consequently, two Compact Multimission Aircraft Propulsion Simulator (CMAPS) units were statically tested at sea level ambient conditions to establish simulator operating performance characteristics and to calibrate the compressor airflow against an accurate bellmouth flowmeter in the presence of inlet flow distortions. The distortions were generated using various-shaped wire mesh screens placed upstream of the compressor. CMAPS operating maps and performance envelopes were obtained for inlet total pressure distortions (ratio of the difference between the maximum and minimum total pressures to the average total pressure) up to 35 percent, and were compared to baseline simulator operating characteristics for a uniform inlet. Deviations from CMAPS baseline performance were attributed to the coupled variation of both compressor inlet-flow distortion and Reynolds number index throughout the simulator operating envelope for each screen configuration. Four independent methods were used to determine CMAPS compressor airflow; direct compressor inlet and discharge measurements, an entering/exiting flow-balance relationships, and a correlation between the mixer pressure and the corrected compressor airflow. Of the four methods, the last yielded the least scatter in the compressor flow coefficient, approximately + or - 3 percent over the range of flow distortions.

The experimental study of matching between centrifugal compressor impeller and diffuser

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tamaki, H.; Nakao, H.; Saito, M.

1999-01-01

the centrifugal compressor for a marine use turbocharger with its design pressure ratio of 3.2 was tested with a vaneless diffuser and various vaned diffusers. Vaned diffusers were chosen to cover impeller operating range as broad as possible. The analysis of the static pressure ratio in the impeller and the diffusing system, consisting of the diffuser and scroll, showed that there were four possible combinations of characteristics of impeller pressure ratio and diffusing system pressure ratio. The flow rate, Q{sub P}, where the impeller achieved maximum static pressure ratio, was surge flow rate of the centrifugal compressor determined by themore » critical flow rate. In order to operate the compressor at a rate lower than Q{sub P}, the diffusing system, whose pressure recovery factor was steep negative slope near Q{sub P}, was needed. When the diffuser throat area was less than a certain value, the compressor efficiency deteriorated; however, the compressor stage pressure ratio was almost constant. In this study, by reducing the diffuser throat area, the compressor could be operated at a flow rate less than 40% of its design flow rate. Analysis of the pressure ratio in the impeller and diffusing systems at design and off-design speeds showed that the irregularities in surge line occurred when the component that controlled the negative slope on the compressor stage pressure ratio changed.« less

Active identification and control of aerodynamic instabilities in axial and centrifugal compressors

NASA Astrophysics Data System (ADS)

Krichene, Assad

In this thesis, it is experimentally shown that dynamic cursors to stall and surge exist in both axial and centrifugal compressors using the experimental axial and centrifugal compressor rigs located in the School of Aerospace Engineering at the Georgia Institute of Technology. Further, it is shown that the dynamic cursors to stall and surge can be identified in real-time and they can be used in a simple control scheme to avoid the occurrence of stall and surge instabilities altogether. For the centrifugal compressor, a previously developed real-time observer is used in order to detect dynamic cursors to surge in real-time. An off-line analysis using the Fast Fourier Transform (FFT) of the open loop experimental data from the centrifugal compressor rig is carried out to establish the influence of compressor speed on the dynamic cursor frequency. The variation of the amplitude of dynamic cursors with compressor operating condition from experimental data is qualitatively compared with simulation results obtained using a generic compression system model subjected to white noise excitation. Using off-line analysis results, a simple control scheme based on fuzzy logic is synthesized for surge avoidance and recovery. The control scheme is implemented in the centrifugal compressor rig using compressor bleed as well as fuel flow to the combustor. Closed loop experimental results are obtained to demonstrate the effectiveness of the controller for both surge avoidance and surge recovery. The existence of stall cursors in an axial compression system is established using the observer scheme from off-line analysis of an existing database of a commercial gas turbine engine. However, the observer scheme is found to be ineffective in detecting stall cursors in the experimental axial compressor rig in the School of Aerospace Engineering at the Georgia Institute of Technology. An alternate scheme based on the amplitude of pressure data content at the blade passage frequency obtained using a pressure sensor located (in the casing) over the blade row is developed and used in the axial compressor rig for stall and surge avoidance and recovery. (Abstract shortened by UMI.)

A Prospective Comparison of Robotic and Laparoscopic Pyeloplasty

PubMed Central

Link, Richard E.; Bhayani, Sam B.; Kavoussi, Louis R.

2006-01-01

Objective: To determine whether robotic-assisted pyeloplasty (RLP) has any significant clinical or cost advantages over laparoscopic pyeloplasty (LP) for surgeons already facile with intracorporeal suturing. Summary Background Data: LP has become an established management approach for primary ureteropelvic junction obstruction. More recently, the da Vinci robot has been applied to this procedure (RLP) in an attempt to shorten the learning curve. Whether RLP provides any significant advantage over LP for the experienced laparoscopist remains unclear. Methods: Ten consecutive cases each of transperitoneal RLP and LP performed by a single surgeon were compared prospectively with respect to surgical times and perioperative outcomes. Cost assessment was performed by sensitivity analysis using a mathematical cost model incorporating operative time, anesthesia fees, consumables, and capital equipment depreciation. Results: The RLP and LP groups had statistically indistinguishable demographics, pathology, and similar perioperative outcomes. Mean operative and total room time for RLP was significantly longer than LP by 19.5 and 39.0 minutes, respectively. RLP was much more costly than LP (2.7 times), due to longer operative time, increased consumables costs, and depreciation of the costly da Vinci system. However, even if depreciation was eliminated, RLP was still 1.7 times as costly as LP. One-way sensitivity analysis showed that LP operative time must increase to almost 6.5 hours for it to become cost equivalent to RLP. Conclusions: For the experienced laparoscopist, application of the da Vinci robot resulted in no significant clinical advantage and added substantial cost to transperitoneal laparoscopic dismembered pyeloplasty. PMID:16552199

A prospective comparison of robotic and laparoscopic pyeloplasty.

PubMed

Link, Richard E; Bhayani, Sam B; Kavoussi, Louis R

2006-04-01

To determine whether robotic-assisted pyeloplasty (RLP) has any significant clinical or cost advantages over laparoscopic pyeloplasty (LP) for surgeons already facile with intracorporeal suturing. LP has become an established management approach for primary ureteropelvic junction obstruction. More recently, the da Vinci robot has been applied to this procedure (RLP) in an attempt to shorten the learning curve. Whether RLP provides any significant advantage over LP for the experienced laparoscopist remains unclear. Ten consecutive cases each of transperitoneal RLP and LP performed by a single surgeon were compared prospectively with respect to surgical times and perioperative outcomes. Cost assessment was performed by sensitivity analysis using a mathematical cost model incorporating operative time, anesthesia fees, consumables, and capital equipment depreciation. The RLP and LP groups had statistically indistinguishable demographics, pathology, and similar perioperative outcomes. Mean operative and total room time for RLP was significantly longer than LP by 19.5 and 39.0 minutes, respectively. RLP was much more costly than LP (2.7 times), due to longer operative time, increased consumables costs, and depreciation of the costly da Vinci system. However, even if depreciation was eliminated, RLP was still 1.7 times as costly as LP. One-way sensitivity analysis showed that LP operative time must increase to almost 6.5 hours for it to become cost equivalent to RLP. For the experienced laparoscopist, application of the da Vinci robot resulted in no significant clinical advantage and added substantial cost to transperitoneal laparoscopic dismembered pyeloplasty.

Expanding proteome coverage with orthogonal-specificity α-Lytic proteases

DOE Office of Scientific and Technical Information (OSTI.GOV)

Meyer, Jesse G.; Kim, Sangtae; Maltby, David A.

2014-03-01

Bottom-up proteomics studies traditionally involve proteome digestion with a single protease, trypsin. However, trypsin alone does not generate peptides that encompass the entire proteome. Alternative proteases have been explored, but most have specificity for charged amino acid side chains. Therefore, additional proteases that improve proteome coverage by cleavage at sequences complimentary to trypsin may increase proteome coverage. We demonstrate the novel application of two proteases for bottom-up proteomics: wild type alpha-lytic protease (WaLP), and an active site mutant of WaLP, M190A alpha-lytic protease (MaLP). We assess several relevant factors including MS/MS fragmentation, peptide length, peptide yield, and protease specificity. Bymore » combining data from separate digestions with trypsin, LysC, WaLP, and MaLP, proteome coverage was increased 101% compared to trypsin digestion alone. To demonstrate how the gained sequence coverage can access additional PTM information, we show identification of a number of novel phosphorylation sites in the S. pombe proteome and include an illustrative example from the protein MPD2, wherein two novel sites are identified, one in a tryptic peptide too short to identify and the other in a sequence devoid of tryptic sites. The specificity of WaLP and MaLP for aliphatic amino acid side chains was particularly valuable for coverage of membrane protein sequences, which increased 350% when the data from trypsin, LysC, WaLP, and MaLP were combined.« less

KSC-2009-2144

NASA Image and Video Library

2009-03-18

CAPE CANAVERAL, Fla. – The Solid Rocket Booster Retrieval Ship Liberty Star tows a booster to the dock at Hangar AF at Cape Canaveral Air Force Station in Florida. The booster was used during space shuttle Discovery's launch from NASA's Kennedy Space Center in Florida March 15 on mission STS-119. The space shuttle’s solid rocket booster casings and associated flight hardware are recovered at sea after a launch. The spent rockets were recovered by NASA's Solid Rocket Booster Retrieval Ships Freedom Star and Liberty Star. The boosters impact the Atlantic Ocean approximately seven minutes after liftoff. The splashdown area is a square of about six by nine nautical miles located about 140 nautical miles downrange from the launch pad. The retrieval ships are stationed approximately 8 to 10 nautical miles from the impact area at the time of splashdown. As soon as the boosters enter the water, the ships accelerate to a speed of 15 knots and quickly close on the boosters. The pilot chutes and main parachutes are the first items to be brought on board. With the chutes and frustum recovered, attention turns to the boosters. The ship’s tow line is connected and the booster is returned to the Port and, after transfer to a position alongside the ship, to Hangar AF. There, the expended boosters are disassembled, refurbished and reloaded with solid propellant for reuse. Photo credit: NASA/Jack Pfaller

KSC-2009-2141

NASA Image and Video Library

2009-03-18

CAPE CANAVERAL, Fla. – The Solid Rocket Booster Retrieval Ship Liberty Star tows a booster to the dock at Hangar AF at Cape Canaveral Air Force Station in Florida. The booster was used during space shuttle Discovery's launch from NASA's Kennedy Space Center in Florida March 15 on mission STS-119. The space shuttle’s solid rocket booster casings and associated flight hardware are recovered at sea after a launch. The spent rockets were recovered by NASA's Solid Rocket Booster Retrieval Ships Freedom Star and Liberty Star. The boosters impact the Atlantic Ocean approximately seven minutes after liftoff. The splashdown area is a square of about six by nine nautical miles located about 140 nautical miles downrange from the launch pad. The retrieval ships are stationed approximately 8 to 10 nautical miles from the impact area at the time of splashdown. As soon as the boosters enter the water, the ships accelerate to a speed of 15 knots and quickly close on the boosters. The pilot chutes and main parachutes are the first items to be brought on board. With the chutes and frustum recovered, attention turns to the boosters. The ship’s tow line is connected and the booster is returned to the Port and, after transfer to a position alongside the ship, to Hangar AF. There, the expended boosters are disassembled, refurbished and reloaded with solid propellant for reuse. Photo credit: NASA/Jack Pfaller

Pressure-Equalizing Cradle for Booster Rocket Mounting

NASA Technical Reports Server (NTRS)

Rutan, Elbert L. (Inventor)

2015-01-01

A launch system and method improve the launch efficiency of a booster rocket and payload. A launch aircraft atop which the booster rocket is mounted in a cradle, is flown or towed to an elevation at which the booster rocket is released. The cradle provides for reduced structural requirements for the booster rocket by including a compressible layer, that may be provided by a plurality of gas or liquid-filled flexible chambers. The compressible layer contacts the booster rocket along most of the length of the booster rocket to distribute applied pressure, nearly eliminating bending loads. Distributing the pressure eliminates point loading conditions and bending moments that would otherwise be generated in the booster rocket structure during carrying. The chambers may be balloons distributed in rows and columns within the cradle or cylindrical chambers extending along a length of the cradle. The cradle may include a manifold communicating gas between chambers.

Factors Affecting Booster Seat Use.

PubMed

Aita-Levy, Jerussa; Henderson, Lauren

2016-10-01

Objective To identify general awareness of booster seats as well as reasons for use and nonuse in an urban pediatric emergency room. Methods A total of 100 questionnaires were completed consisting of 24 questions each. Questions included knowledge of booster seat guidelines, source of knowledge, awareness of risks, and confidence in booster seats. Afterward, participants were provided an educational handout. Results Majority of parents reported currently using or having used a booster seat. The most popular reason was to protect from injury (78%), and reason for nonuse was size (44%). Majority of parents agreed that motor vehicle crashes were the leading cause of death in children. However, 56% of parents prematurely transitioned child out of a booster seat. Only 20% reported learning about booster seats from their pediatrician. Conclusion Parents continue to transition their children prematurely from booster seats. Current state laws need revision as well as further education using simplified illustrated guidelines. © The Author(s) 2015.

78 FR 32294 - DeltaPoint Capital IV, L.P., DeltaPoint Capital IV (New York), L.P., License No. 02/02-0662,02/02...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-29

... Small Business Investment Act of 1958, as amended (``the Act''), in connection with the financing of a... SMALL BUSINESS ADMINISTRATION DeltaPoint Capital IV, L.P., DeltaPoint Capital IV (New York), L.P., License No. 02/02-0662,02/02-0661; Notice Seeking Exemption Under Section 312 of the Small Business...

Production and characterization of a tributyrin esterase from Lactobacillus plantarum suitable for cheese lipolysis.

PubMed

Esteban-Torres, M; Mancheño, J M; de las Rivas, B; Muñoz, R

2014-11-01

Lactobacillus plantarum is a lactic acid bacterium that can be found during cheese ripening. Lipolysis of milk triacylglycerols to free fatty acids during cheese ripening has fundamental consequences on cheese flavor. In the present study, the gene lp_1760, encoding a putative esterase or lipase, was cloned and expressed in Escherichia coli BL21 (DE3) and the overproduced Lp_1760 protein was biochemically characterized. Lp_1760 hydrolyzed p-nitrophenyl esters of fatty acids from C2 to C16, with a preference for p-nitrophenyl butyrate. On triglycerides, Lp_1760 showed higher activity on tributyrin than on triacetin. Although optimal conditions for activity were 45°C and pH 7, Lp_1760 retains activity under conditions commonly found during cheese making and ripening. The Lp_1760 showed more than 50% activity at 5°C and exhibited thermal stability at high temperatures. Enzymatic activity was strongly inhibited by sodium dodecyl sulfate and phenylmethylsulfonyl fluoride. The Lp_1760 tributyrin esterase showed high activity in the presence of NaCl, lactic acid, and calcium chloride. The results suggest that Lp_1760 might be a useful tributyrin esterase to be used in cheese manufacturing. Copyright © 2014 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Misuse of booster cushions among children and adults in Shanghai-an observational and attitude study during buckling up.

PubMed

Bohman, Katarina; Jorlöv, Sofia; Zhou, Shengqi; Zhao, Cloud; Sui, Bo; Ding, Chengkai

2016-10-02

Traffic crashes are one of the leading causes of fatalities among Chinese children. Booster cushion usage in China is low, and there are no studies showing how a population with limited experience handles booster cushions during buckling up. The purpose of this study was to evaluate the handling of and explore the attitudes toward booster cushions among children, parents, and grandparents in Shanghai. An observational study including a convenience sample of 254 children aged 4-12 years was conducted in 2 passenger cars at a shopping center in Shanghai. Parents, grandparents, or the children themselves buckled up the child on 2 types of booster cushions, a 2-stage integrated booster cushion (IBC) and an aftermarket booster cushion (BC). The test participants were observed during buckling up, first without and then with instructions. The test leaders conducted structured interviews. Ninety-eight percent of the uninstructed participants failed to buckle up without identified misuse on the aftermarket booster cushion and 31% of those uninstructed on the integrated booster cushion. The majority of misuse was severe, including placing the belt behind the arm and the lap belt routing above the guiding loops. Instruction reduced misuse to 58% (BC) and 12% (IBC), respectively, and, in particular, severe misuse. Some misuse was related to limited knowledge of how to buckle up on the booster cushion, and some misuse was intentional in order to reduce discomfort. The participants, both children and adults, reported that they preferred the IBC due to good comfort and convenience. Safety was reported as the main reason for adults using booster cushions in general, whereas children reported comfort as the most important motivation. Education is needed to ensure frequent and correct use of booster cushions in China and to raise safety awareness among children and adults. Furthermore, it is important that the booster cushions offer intuitively correct usage to a population with limited experience of booster cushions. This is the first study published on the handling of and attitude toward booster cushions after child restraints laws were introduced in Shanghai 2014.

Rotor whirl forces induced by the tip clearance effect in axial flow compressors

NASA Astrophysics Data System (ADS)

Ehrich, F.

1993-10-01

It is now widely recognized that destabilizing forces, tending to generate forward rotor whirl, are generated in axial flow turbines as a result of the nonuniform torque induced by the nonuniform tip-clearance in a deflected rotor-the so called Thomas/Alford force (Thomas, 1958, and Alford, 1965). It is also recognized that there will be a similar effect in axial flow compressors, but qualitative considerations cannot definitively establish the magnitude or even the direction of the induced whirling forces-that is, if they will tend to forward or backward whirl. Applying a 'parallel compressor' model to simulate the operation of a compressor rotor deflected radially in its clearance, it is possible to derive a quantitative estimate of the proportionality factor which relates the Thomas/Alford force in axial flow compressors (i.e., the tangential force generated by a radial deflection of the rotor) to the torque level in the compressor. The analysis makes use of experimental data from the GE Aircraft Engines Low Speed Research Compressor facility comparing the performance of three different axial flow compressors, each with four stages (typical of a mid-block of an aircraft gas turbine compressor) at two different clearances (expressed as a percent of blade length) - CL/L = 1.4 percent and CL/L = 2.8 percent. It is found that the value of Beta is in the range of + 0.27 to - 0.71 in the vicinity of the stages' nominal operating line and + 0.08 to - 1.25 in the vicinity of the stages' operation at peak efficiency. The value of Beta reaches a level of between - 1.16 and - 3.36 as the compressor is operated near its stalled condition. The final result bears a very strong resemblance to the correlation obtained by improvising a normalization of the experimental data of Vance and Laudadio (1984) and a generic relationship to the analytic results of Colding-Jorgensen (1990).

Gas turbine engine adapted for use in combination with an apparatus for separating a portion of oxygen from compressed air

DOEpatents

Bland, Robert J [Oviedo, FL; Horazak, Dennis A [Orlando, FL

2012-03-06

A gas turbine engine is provided comprising an outer shell, a compressor assembly, at least one combustor assembly, a turbine assembly and duct structure. The outer shell includes a compressor section, a combustor section, an intermediate section and a turbine section. The intermediate section includes at least one first opening and at least one second opening. The compressor assembly is located in the compressor section to define with the compressor section a compressor apparatus to compress air. The at least one combustor assembly is coupled to the combustor section to define with the combustor section a combustor apparatus. The turbine assembly is located in the turbine section to define with the turbine section a turbine apparatus. The duct structure is coupled to the intermediate section to receive at least a portion of the compressed air from the compressor apparatus through the at least one first opening in the intermediate section, pass the compressed air to an apparatus for separating a portion of oxygen from the compressed air to produced vitiated compressed air and return the vitiated compressed air to the intermediate section via the at least one second opening in the intermediate section.

Performance test results of 80 K centrifugal compressor for helium refrigerator

DOE Office of Scientific and Technical Information (OSTI.GOV)

Asakura, H.; Kato, D.; Saji, N.

1994-12-31

The authors have developed a completely oil-free compressor used for the highly reliable helium refrigeration system for a superconducting generator and carried out performance tests under actual condition. The compressor is designed to achieve a pressure ratio of 8 with only 4 stages by cooling the compressor inlet at 80 K with liquid nitrogen, thus acquiring high reliability of long-term maintenance-free operation together with the use of magnetic bearings for oil-free operation. The compressor at each stage is independently driven by a 25 kW built-in motor at the speed of 100,000 rpm, with the power supplied by a variable frequencymore » inverter. The performance test was carried out at each stage, by incorporating the compressor in the closed loop test equipment using helium gas. It was recognized from the test results that the specified pressure ratio of each stage was achieved at the speed below the rated one of 100,000 rpm. It was found that each stage of the compressor has a flat characteristics of adiabatic efficiency over the wide flow range. The mechanical rotation characteristics at low temperatures was also confirmed to be sufficiently stable.« less

Effect of CuO nanolubricant on compressor characteristics and performance of LPG based refrigeration cycle: experimental investigation

NASA Astrophysics Data System (ADS)

Kumar, Ravinder; Singh, Jagdev; Kundal, Pankaj

2018-05-01

Refrigeration, Ventilation and Air Conditioning system is the largest reason behind the increasing demand of energy consumption in the world and saving that energy through some innovative methods becomes a large issue for the researchers. Compressor is a primary component of the refrigeration cycle. The application of nanoparticles in refrigeration cycle overcomes the energy consumption issue by improving the compressor suction and discharge characteristics. In this paper, an experimental study is carried out to investigate the effect of copper oxide (CuO) nanoparticles on different parameters of the refrigeration cycle. CuO particles are appended with the system refrigerant through lubricating oil of the compressor. Further, the viscosity measurements and friction coefficient analysis of compressor lubricant for different fractions of nanoparticles has been investigated. The results showed that both the suction and discharge characteristics of the compressor were enhanced with the utilization of nanolubricant in LPG based refrigeration cycle. Nanoparticles additive in lubricant increases the viscosity which lead to a significant decrease in friction coefficient. The COP of the cycle was improved by 46%, as the energy consumption of the compressor was decreased by 7%.

An Investigation of Surge in a High-Speed Centrifugal Compressor Using Digital PIV

NASA Technical Reports Server (NTRS)

Wernet, Mark P.; Bright, Michelle M.; Skoch, Gary J.

2001-01-01

Compressor stall is a catastrophic breakdown of the flow in a compressor, which con lead to a loss of engine power, large pressure transients in the inlet/nacelle, and engine flameout. The implementation of active or passive strategies for controlling rotating stall and surge can significantly extend the stable operating range of a compressor without substantially sacrificing performance. It is crucial to identify the dynamic changes occurring in the flow field prior to rotating stall and surge in order to control these events successfully. Generally, pressure transducer measurements are made to capture the transient response of a compressor prior to rotating stall. In this investigation, Digital Particle Imaging Velocimetry (DPIV) is used in conjunction with dynamic pressure transducers to capture transient velocity and pressure measurements simultaneously in the nonstationary flow field during compressor surge. DPIV is an instantaneous, planar measurement technique that is ideally suited for studying transient flow phenomena in highspeed turbomachinery and has been used previously to map the stable operating point flow field in the diffuser of a high-speed centrifugal compressor. Through the acquisition of both DPIV images and transient pressure data, the time evolution of the unsteady flow during surge is revealed.

Acoustical contribution calculation and analysis of compressor shell based on acoustic transfer vector method

NASA Astrophysics Data System (ADS)

Chen, Xiaol; Guo, Bei; Tuo, Jinliang; Zhou, Ruixin; Lu, Yang

2017-08-01

Nowadays, people are paying more and more attention to the noise reduction of household refrigerator compressor. This paper established a sound field bounded by compressor shell and ISO3744 standard field points. The Acoustic Transfer Vector (ATV) in the sound field radiated by a refrigerator compressor shell were calculated which fits the test result preferably. Then the compressor shell surface is divided into several parts. Based on Acoustic Transfer Vector approach, the sound pressure contribution to the field points and the sound power contribution to the sound field of each part were calculated. To obtain the noise radiation in the sound field, the sound pressure cloud charts were analyzed, and the contribution curves in different frequency of each part were acquired. Meanwhile, the sound power contribution of each part in different frequency was analyzed, to ensure those parts where contributes larger sound power. Through the analysis of acoustic contribution, those parts where radiate larger noise on the compressor shell were determined. This paper provides a credible and effective approach on the structure optimal design of refrigerator compressor shell, which is meaningful in the noise and vibration reduction.

Towards Large Eddy Simulation of gas turbine compressors

NASA Astrophysics Data System (ADS)

McMullan, W. A.; Page, G. J.

2012-07-01

With increasing computing power, Large Eddy Simulation could be a useful simulation tool for gas turbine axial compressor design. This paper outlines a series of simulations performed on compressor geometries, ranging from a Controlled Diffusion Cascade stator blade to the periodic sector of a stage in a 3.5 stage axial compressor. The simulation results show that LES may offer advantages over traditional RANS methods when off-design conditions are considered - flow regimes where RANS models often fail to converge. The time-dependent nature of LES permits the resolution of transient flow structures, and can elucidate new mechanisms of vorticity generation on blade surfaces. It is shown that accurate LES is heavily reliant on both the near-wall mesh fidelity and the ability of the imposed inflow condition to recreate the conditions found in the reference experiment. For components embedded in a compressor this requires the generation of turbulence fluctuations at the inlet plane. A recycling method is developed that improves the quality of the flow in a single stage calculation of an axial compressor, and indicates that future developments in both the recycling technique and computing power will bring simulations of axial compressors within reach of industry in the coming years.

Stage-by-Stage and Parallel Flow Path Compressor Modeling for a Variable Cycle Engine, NASA Advanced Air Vehicles Program - Commercial Supersonic Technology Project - AeroServoElasticity

NASA Technical Reports Server (NTRS)

Kopasakis, George; Connolly, Joseph W.; Cheng, Larry

2015-01-01

This paper covers the development of stage-by-stage and parallel flow path compressor modeling approaches for a Variable Cycle Engine. The stage-by-stage compressor modeling approach is an extension of a technique for lumped volume dynamics and performance characteristic modeling. It was developed to improve the accuracy of axial compressor dynamics over lumped volume dynamics modeling. The stage-by-stage compressor model presented here is formulated into a parallel flow path model that includes both axial and rotational dynamics. This is done to enable the study of compressor and propulsion system dynamic performance under flow distortion conditions. The approaches utilized here are generic and should be applicable for the modeling of any axial flow compressor design accurate time domain simulations. The objective of this work is as follows. Given the parameters describing the conditions of atmospheric disturbances, and utilizing the derived formulations, directly compute the transfer function poles and zeros describing these disturbances for acoustic velocity, temperature, pressure, and density. Time domain simulations of representative atmospheric turbulence can then be developed by utilizing these computed transfer functions together with the disturbance frequencies of interest.

An Investigation of Surge in a High-Speed Centrifugal Compressor Using Digital PIV

NASA Technical Reports Server (NTRS)

Wernet, Mark P.; Bright, Michelle M.; Skoch, Gary J.

2002-01-01

Compressor stall is a catastrophic breakdown of the flow in a compressor, which can lead to a loss of engine power, large pressure transients in the inlet/nacelle and engine flameout. The implementation of active or passive strategies for controlling rotating stall and surge can significantly extend the stable operating range of a compressor without substantially sacrificing performance. It is crucial to identify the dynamic changes occurring in the flow field prior to rotating stall and surge in order to successfully control these events. Generally, pressure transducer measurements are made to capture the transient response of a compressor prior to rotating stall. In this investigation, Digital Particle Imaging Velocimetry (DPIV) is used in conjunction with dynamic pressure transducers to simultaneously capture transient velocity and pressure measurements in the non-stationary flow field during compressor surge. DPIV is an instantaneous, planar measurement technique which is ideally suited for studying transient flow phenomena in high speed turbomachinery and has been used previously to successfully map the stable operating point flow field in the diffuser of a high speed centrifugal compressor. Through the acquisition of both DPIV images and transient pressure data, the time evolution of the unsteady flow during surge is revealed.

A similitude method and the corresponding blade design of a low-speed large-scale axial compressor rotor

NASA Astrophysics Data System (ADS)

Yu, Chenghai; Ma, Ning; Wang, Kai; Du, Juan; Van den Braembussche, R. A.; Lin, Feng

2014-04-01

A similitude method to model the tip clearance flow in a high-speed compressor with a low-speed model is presented in this paper. The first step of this method is the derivation of similarity criteria for tip clearance flow, on the basis of an inviscid model of tip clearance flow. The aerodynamic parameters needed for the model design are then obtained from a numerical simulation of the target high-speed compressor rotor. According to the aerodynamic and geometric parameters of the target compressor rotor, a large-scale low-speed rotor blade is designed with an inverse blade design program. In order to validate the similitude method, the features of tip clearance flow in the low-speed model compressor are compared with the ones in the high-speed compressor at both design and small flow rate points. It is found that not only the trajectory of the tip leakage vortex but also the interface between the tip leakage flow and the incoming main flow in the high-speed compressor match well with that of its low speed model. These results validate the effectiveness of the similitude method for the tip clearance flow proposed in this paper.

The New Performance Calculation Method of Fouled Axial Flow Compressor

PubMed Central

Xu, Hong

2014-01-01

Fouling is the most important performance degradation factor, so it is necessary to accurately predict the effect of fouling on engine performance. In the previous research, it is very difficult to accurately model the fouled axial flow compressor. This paper develops a new performance calculation method of fouled multistage axial flow compressor based on experiment result and operating data. For multistage compressor, the whole compressor is decomposed into two sections. The first section includes the first 50% stages which reflect the fouling level, and the second section includes the last 50% stages which are viewed as the clean stage because of less deposits. In this model, the performance of the first section is obtained by combining scaling law method and linear progression model with traditional stage stacking method; simultaneously ambient conditions and engine configurations are considered. On the other hand, the performance of the second section is calculated by averaged infinitesimal stage method which is based on Reynolds' law of similarity. Finally, the model is successfully applied to predict the 8-stage axial flow compressor and 16-stage LM2500-30 compressor. The change of thermodynamic parameters such as pressure ratio, efficiency with the operating time, and stage number is analyzed in detail. PMID:25197717

Cooled spool piston compressor

NASA Technical Reports Server (NTRS)

Morris, Brian G. (Inventor)

1993-01-01

A hydraulically powered gas compressor receives low pressure gas and outputs a high pressure gas. The housing of the compressor defines a cylinder with a center chamber having a cross-sectional area less than the cross-sectional area of a left end chamber and a right end chamber, and a spool-type piston assembly is movable within the cylinder and includes a left end closure, a right end closure, and a center body that are in sealing engagement with the respective cylinder walls as the piston reciprocates. First and second annual compression chambers are provided between the piston enclosures and center housing portion of the compressor, thereby minimizing the spacing between the core gas and a cooled surface of the compressor. Restricted flow passageways are provided in the piston closure members and a path is provided in the central body of the piston assembly, such that hydraulic fluid flows through the piston assembly to cool the piston assembly during its operation. The compressor of the present invention may be easily adapted for a particular application, and is capable of generating high gas pressures while maintaining both the compressed gas and the compressor components within acceptable temperature limits.

Modification of a compressor performance test bench for liquid slugging observation in refrigeration compressors

NASA Astrophysics Data System (ADS)

Ola, Max; Thomas, Christiane; Hesse, Ullrich

2017-08-01

Compressor performance test procedures are defined by the standard DIN EN 13771, wherein a variety of possible calorimeter and flow rate measurement methods are suggested. One option is the selection of two independent measurement methods. The accuracies of both selected measurement methods are essential. The second option requires only one method. However the measurement accuracy of the used device has to be verified and recalibrated on a regular basis. The compressor performance test facility at the Technische Universitaet Dresden uses a calibrated flow measurement sensor, a hot gas bypass and a mixed flow heat exchanger. The test bench can easily be modified for tests of various compressor types at different operating ranges and with various refrigerants. In addition, the modified test setup enables the investigation of long term liquid slug and its effects on the compressor. The modification comprises observational components, adjustments of the control system, safety measures and a customized oil recirculation system for compressors which do not contain an integrated oil sump or oil level regulation system. This paper describes the setup of the test bench, its functional principle, the key modifications, first test results and an evaluation of the energy balance.

NASA's Space Launch System Advanced Booster Engineering Demonstration and/or Risk Reduction Efforts

NASA Technical Reports Server (NTRS)

Crumbly, Christopher M.; Dumbacher, Daniel L.; May, Todd A.

2012-01-01

The National Aeronautics and Space Administration (NASA) formally initiated the Space Launch System (SLS) development in September 2011, with the approval of the program s acquisition plan, which engages the current workforce and infrastructure to deliver an initial 70 metric ton (t) SLS capability in 2017, while using planned block upgrades to evolve to a full 130 t capability after 2021. A key component of the acquisition plan is a three-phased approach for the first stage boosters. The first phase is to complete the development of the Ares and Space Shuttle heritage 5-segment solid rocket boosters (SRBs) for initial exploration missions in 2017 and 2021. The second phase in the booster acquisition plan is the Advanced Booster Risk Reduction and/or Engineering Demonstration NASA Research Announcement (NRA), which was recently awarded after a full and open competition. The NRA was released to industry on February 9, 2012, with a stated intent to reduce risks leading to an affordable advanced booster and to enable competition. The third and final phase will be a full and open competition for Design, Development, Test, and Evaluation (DDT&E) of the advanced boosters. There are no existing boosters that can meet the performance requirements for the 130 t class SLS. The expected thrust class of the advanced boosters is potentially double the current 5-segment solid rocket booster capability. These new boosters will enable the flexible path approach to space exploration beyond Earth orbit (BEO), opening up vast opportunities including near-Earth asteroids, Lagrange Points, and Mars. This evolved capability offers large volume for science missions and payloads, will be modular and flexible, and will be right-sized for mission requirements. NASA developed the Advanced Booster Engineering Demonstration and/or Risk Reduction NRA to seek industry participation in reducing risks leading to an affordable advanced booster that meets the SLS performance requirements. Demonstrations and/or risk reduction efforts were required to be related to a proposed booster concept directly applicable to fielding an advanced booster. This paper will discuss, for the first time publicly, the contract awards and how NASA intends to use the data from these efforts to prepare for the planned advanced booster DDT&E acquisition as the SLS Program moves forward with competitively procured affordable performance enhancements.

NASA's Space Launch System Advanced Booster Engineering Demonstration and Risk Reduction Efforts

NASA Technical Reports Server (NTRS)

Crumbly, Christopher M.; May, Todd; Dumbacher, Daniel

2012-01-01

The National Aeronautics and Space Administration (NASA) formally initiated the Space Launch System (SLS) development in September 2011, with the approval of the program s acquisition plan, which engages the current workforce and infrastructure to deliver an initial 70 metric ton (t) SLS capability in 2017, while using planned block upgrades to evolve to a full 130 t capability after 2021. A key component of the acquisition plan is a three-phased approach for the first stage boosters. The first phase is to complete the development of the Ares and Space Shuttle heritage 5-segment solid rocket boosters for initial exploration missions in 2017 and 2021. The second phase in the booster acquisition plan is the Advanced Booster Risk Reduction and/or Engineering Demonstration NASA Research Announcement (NRA), which was recently awarded after a full and open competition. The NRA was released to industry on February 9, 2012, and its stated intent was to reduce risks leading to an affordable Advanced Booster and to enable competition. The third and final phase will be a full and open competition for Design, Development, Test, and Evaluation (DDT&E) of the Advanced Boosters. There are no existing boosters that can meet the performance requirements for the 130 t class SLS. The expected thrust class of the Advanced Boosters is potentially double the current 5-segment solid rocket booster capability. These new boosters will enable the flexible path approach to space exploration beyond Earth orbit, opening up vast opportunities including near-Earth asteroids, Lagrange Points, and Mars. This evolved capability offers large volume for science missions and payloads, will be modular and flexible, and will be right-sized for mission requirements. NASA developed the Advanced Booster Engineering Demonstration and/or Risk Reduction NRA to seek industry participation in reducing risks leading to an affordable Advanced Booster that meets the SLS performance requirements. Demonstrations and/or risk reduction efforts were required to be related to a proposed booster concept directly applicable to fielding an Advanced Booster. This paper will discuss, for the first time publicly, the contract awards and how NASA intends to use the data from these efforts to prepare for the planned Advanced Booster DDT&E acquisition as the SLS Program moves forward with competitively procured affordable performance enhancements.

Long-term immunogenicity of an initial booster dose of an inactivated, Vero cell culture-derived Japanese encephalitis vaccine (JE-VC) and the safety and immunogenicity of a second JE-VC booster dose in children previously vaccinated with an inactivated, mouse brain-derived Japanese encephalitis vaccine.

PubMed

Yun, Ki Wook; Lee, Hoan Jong; Park, Ji Young; Cho, Hye-Kyung; Kim, Yae-Jean; Kim, Kyung-Hyo; Kim, Nam Hee; Hong, Young Jin; Kim, Dong Ho; Kim, Hwang Min; Cha, Sung-Ho

2018-03-07

This study was performed with the aim of determining the long-term immunogenicity of an inactivated, Vero cell culture-derived Japanese encephalitis (JE) vaccine (JE-VC) and an inactivated, mouse brain-derived JE vaccine (JE-MB) after the 1st booster dose at 2 years of age, as well as the safety and immunogenicity of the 2nd booster dose of JE-VC at 6 years of age, in children primed and given a 1st booster dose of either JE-VC or JE-MB. In this multicenter, open-label clinical trial, the study population consisted of healthy Korean children (aged 6 years) who participated in the previous JE vaccine trial. All subjects were subcutaneously vaccinated once for the booster immunization with Boryung Cell Culture Japanese Encephalitis Vaccine® (JE-VC). Approximately 4 years after the 1st booster dose of JE-VC, the seroprotection rate (SPR) and geometric mean titer (GMT) of the neutralizing antibody were 100% and 1113.8, respectively. In children primed and given a 1st booster dose of JE-MB, the SPR and GMT were 88.5% and 56.3, respectively. After the 2nd booster dose of JE-VC, all participants primed and given a 1st booster dose of either JE-MB or JE-VC were seroprotective against JE virus. The GMT of the neutralizing antibody was higher in children primed and given a 1st booster dose of JE-VC (8144.1) than in those primed and given a 1st booster dose of JE-MB (942.5) after the vaccination (p < 0.001). In addition, the 2nd booster dose of JE-VC showed a good safety profile with no serious vaccine-related adverse events. The 1st booster dose of JE-VC and JE-MB showed long-term immunogenicity of at least 4 years, and the 2nd booster dose of JE-VC showed a good safety and immunogenicity profile in children primed and given a 1st booster dose of either JE-VC or JE-MB. ClinicalTtrials.gov Identifier: NCT02532569. Copyright © 2018 Elsevier Ltd. All rights reserved.

Immunohistochemical expression of perforin in lichen planus lesions.

PubMed

Gaber, Mohamed Abdelwahed; Maraee, Alaa Hassan; Alsheraky, Dalia Rifaat; Azeem, Marwa Hussain Abdel

2014-12-01

Lichen planus (LP) is a chronic inflammatory papulosquamous skin disease characterized by epidermal basal cell damage and a particular band-like infiltrate predominantly of T cells in the upper dermis. It is characterized by the formation of colloid bodies representing apoptotic keratinocytes. The apoptotic process mediated by CD8+ cytotoxic T lymphocytes and natural killer cells mainly involves two distinct pathways: the perforin/granzyme pathway and the Fas/FasL pathway. So far, little is known regarding the role of perforin-mediated apoptosis in LP. Is to study the expression and distribution of perforin in the epidermis and dermis of lesional LP skin. Skin biopsy specimens from lesional skin of 31 patients with LP and 10 healthy persons were analyzed by immunohistochemistry. Significant accumulation of perforin + cells was found in both epidermis and dermis of LP lesions compared with healthy skin. Perforin expression was significantly upregulated in the epidermis of LP lesions. Accumulation of perforin + cells in the epidermis of LP lesions suggest a potential role of perforin in the apoptosis of basal keratinocytes.

KSC-08pd0736

NASA Image and Video Library

2008-03-12

KENNEDY SPACE CENTER, FLA. -- The Freedom Star, one of NASA's solid rocket booster retrieval ships, motors through Port Canaveral with a solid rocket booster alongside. The booster is from space shuttle Endeavour, which launched the STS-123 mission on March 11. The space shuttle’s solid rocket booster casings and associated flight hardware are recovered at sea. The boosters impact the Atlantic Ocean approximately seven minutes after liftoff. The splashdown area is a square of about 6 by 9 nautical miles located about 140 nautical miles downrange from the launch pad. The retrieval ships are stationed approximately 8 to 10 nautical miles from the impact area at the time of splashdown. As soon as the boosters enter the water, the ships accelerate to a speed of 15 knots and quickly close on the boosters, which they tow back to port. After transfer to a position alongside the ship, the booster will be towed to Hangar AF at Cape Canaveral Air Force Station. There, the expended boosters are disassembled, refurbished and reloaded with solid propellant for reuse. Photo credit: NASA/Jack Pfaller

KSC-08pd0741

NASA Image and Video Library

2008-03-12

KENNEDY SPACE CENTER, FLA. -- The Freedom Star, one of NASA's solid rocket booster retrieval ships, nears Hangar AF at Cape Canaveral Air Force Station with a solid rocket booster alongside. The booster is from space shuttle Endeavour, which launched the STS-123 mission on March 11. The space shuttle’s solid rocket booster casings and associated flight hardware are recovered at sea. The boosters impact the Atlantic Ocean approximately seven minutes after liftoff. The splashdown area is a square of about 6 by 9 nautical miles located about 140 nautical miles downrange from the launch pad. The retrieval ships are stationed approximately 8 to 10 nautical miles from the impact area at the time of splashdown. As soon as the boosters enter the water, the ships accelerate to a speed of 15 knots and quickly close on the boosters, which they tow back to port. After transfer to a position alongside the ship, the booster will be towed to Hangar AF at Cape Canaveral Air Force Station. There, the expended boosters are disassembled, refurbished and reloaded with solid propellant for reuse. Photo credit: NASA/Jack Pfaller

KSC-08pd0738

NASA Image and Video Library

2008-03-12

KENNEDY SPACE CENTER, FLA. -- The Freedom Star, one of NASA's solid rocket booster retrieval ships, crosses through the drawbridge over the Haulover Canal into the Banana River. The ship is towing a solid rocket booster alongside. The booster is from space shuttle Endeavour, which launched the STS-123 mission on March 11. The space shuttle’s solid rocket booster casings and associated flight hardware are recovered at sea. The boosters impact the Atlantic Ocean approximately seven minutes after liftoff. The splashdown area is a square of about 6 by 9 nautical miles located about 140 nautical miles downrange from the launch pad. The retrieval ships are stationed approximately 8 to 10 nautical miles from the impact area at the time of splashdown. As soon as the boosters enter the water, the ships accelerate to a speed of 15 knots and quickly close on the boosters, which they tow back to port. After transfer to a position alongside the ship, the booster will be towed to Hangar AF at Cape Canaveral Air Force Station. There, the expended boosters are disassembled, refurbished and reloaded with solid propellant for reuse. Photo credit: NASA/Jack Pfaller

KSC-08pd0740

NASA Image and Video Library

2008-03-12

KENNEDY SPACE CENTER, FLA. -- The Freedom Star, one of NASA's solid rocket booster retrieval ships, tows a solid rocket booster alongside, heading for Hangar AF at Cape Canaveral Air Force Station. The booster is from space shuttle Endeavour, which launched the STS-123 mission on March 11. The space shuttle’s solid rocket booster casings and associated flight hardware are recovered at sea. The boosters impact the Atlantic Ocean approximately seven minutes after liftoff. The splashdown area is a square of about 6 by 9 nautical miles located about 140 nautical miles downrange from the launch pad. The retrieval ships are stationed approximately 8 to 10 nautical miles from the impact area at the time of splashdown. As soon as the boosters enter the water, the ships accelerate to a speed of 15 knots and quickly close on the boosters, which they tow back to port. After transfer to a position alongside the ship, the booster will be towed to Hangar AF at Cape Canaveral Air Force Station. There, the expended boosters are disassembled, refurbished and reloaded with solid propellant for reuse. Photo credit: NASA/Jack Pfaller

KSC-08pd0737

NASA Image and Video Library

2008-03-12

KENNEDY SPACE CENTER, FLA. -- The Freedom Star, one of NASA's solid rocket booster retrieval ships, motors through Port Canaveral with a solid rocket booster alongside. The booster is from space shuttle Endeavour, which launched the STS-123 mission on March 11. The space shuttle’s solid rocket booster casings and associated flight hardware are recovered at sea. The boosters impact the Atlantic Ocean approximately seven minutes after liftoff. The splashdown area is a square of about 6 by 9 nautical miles located about 140 nautical miles downrange from the launch pad. The retrieval ships are stationed approximately 8 to 10 nautical miles from the impact area at the time of splashdown. As soon as the boosters enter the water, the ships accelerate to a speed of 15 knots and quickly close on the boosters, which they tow back to port. After transfer to a position alongside the ship, the booster will be towed to Hangar AF at Cape Canaveral Air Force Station. There, the expended boosters are disassembled, refurbished and reloaded with solid propellant for reuse. Photo credit: NASA/Jack Pfaller

A compressor designed for the energy research and development agency automotive gas turbine program

NASA Technical Reports Server (NTRS)

Galvas, M. R.

1975-01-01

A centrifugal compressor was designed for a gas turbine powered automobile as part of the Energy Research and Development Agency program to demonstrate emissions characteristics that meet 1978 standards with fuel economy and acceleration which are competitive with conventionally powered vehicles. A backswept impeller was designed for the compressor in order to attain the efficiency goal range required for the objectives of this program. Details of the design and method of flow analysis of the compressor are presented.

Refrigerator with variable capacity compressor and cycle priming action through capacity control and associated methods

DOEpatents

Gomes, Alberto Regio; Litch, Andrew D.; Wu, Guolian

2016-03-15

A refrigerator appliance (and associated method) that includes a condenser, evaporator and a multi-capacity compressor. The appliance also includes a pressure reducing device arranged within an evaporator-condenser refrigerant circuit, and a valve system for directing or restricting refrigerant flow through the device. The appliance further includes a controller for operating the compressor upon the initiation of a compressor ON-cycle at a priming capacity above a nominal capacity for a predetermined or calculated duration.

Evaluation of Bauer K-20 Diesel Drive High Pressure Breathing Air Compressor

DTIC Science & Technology

1993-12-01

was to: A. Determine if the compressor and Purification System provides compressed air at the required pressures, flow rates, quality and cleanliness... compressed air return from the air storage flasks to the compressor during unit shut down. All four stages of the compressor are protected by safety...1993. 6. Naval Ships Technical Manual, S9086-SY-STM-0O0, Chapeter 551 1st Rev. I November 1987. Compressed Air Plants and Systems, para 551-4.2.21. 7

Shelter Deployment at Former Army Camp Tuto, Greenland

DTIC Science & Technology

2014-05-29

compressors Included in the crate 2 air compressors TOTAL Weight 250 lb Size 48 × 24 × 24 in. ERDC/CRREL TN-14-2 3 2 Preparation 2.1 Practice...airbeam-frame inflation Inflation of the airbeam structure was facilitated by a 1.8 hp Dewalt air compressor connected to a Honda 2500 W generator running...off of JP-8 diesel fuel (Figure 11). Both the compressor and generator maintained 100% operability at −20°F ambient. The air compressor’s pressure

Small engine components test facility compressor testing cell at NASA Lewis Research Center

NASA Technical Reports Server (NTRS)

Brokopp, Richard A.; Gronski, Robert S.

1992-01-01

LeRC has designed and constructed a new test facility. This facility, called the Small Engine Components Facility (SECTF) is used to test gas turbines and compressors at conditions similar to actual engine conditions. The SECTF is comprised of a compressor testing cell and a turbine testing cell. Only the compressor testing cell is described. The capability of the facility, the overall facility design, the instrumentation used in the facility, and the data acquisition system are discussed in detail.

Mid-section of a can-annular gas turbine engine with a radial air flow discharged from the compressor section

DOE Office of Scientific and Technical Information (OSTI.GOV)

Little, David A.; McQuiggan, Gerard; Wasdell, David L.

A midframe portion (213) of a gas turbine engine (210) is presented, and includes a compressor section (212) configured to discharge an air flow (211) directed in a radial direction from an outlet of the compressor section (212). Additionally, the midframe portion (213) includes a manifold (214) to directly couple the air flow (211) from the compressor section (212) outlet to an inlet of a respective combustor head (218) of the midframe portion (213).

Screw compressor analysis from a vibration point-of-view

NASA Astrophysics Data System (ADS)

Hübel, D.; Žitek, P.

2017-09-01

Vibrations are a very typical feature of all compressors and are given great attention in the industry. The reason for this interest is primarily the negative influence that it can have on both the operating staff and the entire machine's service life. The purpose of this work is to describe the methodology of screw compressor analysis from a vibration point-of-view. This analysis is an essential part of the design of vibro-diagnostics of screw compressors with regard to their service life.

Turbine Engine with Differential Gear Driven Fan and Compressor

NASA Technical Reports Server (NTRS)

Suciu, Gabriel L. (Inventor); Pagluica, Gino J. (Inventor); Duong, Loc Quang (Inventor); Portlock, Lawrence E. (Inventor)

2013-01-01

A gas turbine engine provides a differential gear system coupling the turbine to the bypass fan and the compressor. In this manner, the power/speed split between the bypass fan and the compressor can be optimized under all conditions. In the example shown, the turbine drives a sun gear, which drives a planet carrier and a ring gear in a differential manner. One of the planet carrier and the ring gear is coupled to the bypass fan, while the other is coupled to the compressor.