76 FR 48904 - Request for Comments-Poverty Data and LSC Funding Distribution

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-09

... LEGAL SERVICES CORPORATION Request for Comments--Poverty Data and LSC Funding Distribution AGENCY... individual in poverty for each geographic area. The appropriation has further mandated that the number of individuals in poverty in each geographic area be determined by the Bureau of the Census ``on the basis of the...

45 CFR 1630.11 - Applicability to non-LSC funds.

Code of Federal Regulations, 2010 CFR

2010-10-01

... an activity prohibited by or inconsistent with section 504, as defined by 45 CFR 1610.2(b), may be... purpose prohibited by the LSC Act, as defined by 45 CFR 1610.2(a), may be charged to private funds, except... provided. (b) According to the review and appeal procedures of 45 CFR 1630.7, the Corporation may recover...

The Impact of European Funding on Mainstream Learning and Skills Council Provision. Research Report

ERIC Educational Resources Information Center

Kirk, Gordon; Fletcher, Mick

2007-01-01

This report summarizes the findings and conclusions from a study designed to identify how European funding supports Learning and Skills Council (LSC) priorities and contributes to LSC targets. The study was carried out between November 2005 and May 2006, and had the three following main components: (1) Consultants examined questionnaires…

45 CFR 1640.3 - Contractual agreement.

Code of Federal Regulations, 2013 CFR

2013-10-01

... OF FEDERAL LAW TO LSC RECIPIENTS § 1640.3 Contractual agreement. As a condition of receiving LSC... respect to its LSC funds, it will be subject to the Federal laws listed in § 1640.2(a)(1). The agreement... such Federal law and of the consequences of a violation of such law, both to the recipient and to...

45 CFR 1640.3 - Contractual agreement.

Code of Federal Regulations, 2010 CFR

2010-10-01

... OF FEDERAL LAW TO LSC RECIPIENTS § 1640.3 Contractual agreement. As a condition of receiving LSC... respect to its LSC funds, it will be subject to the Federal laws listed in § 1640.2(a)(1). The agreement... such Federal law and of the consequences of a violation of such law, both to the recipient and to...

45 CFR 1640.3 - Contractual agreement.

Code of Federal Regulations, 2011 CFR

2011-10-01

... OF FEDERAL LAW TO LSC RECIPIENTS § 1640.3 Contractual agreement. As a condition of receiving LSC... respect to its LSC funds, it will be subject to the Federal laws listed in § 1640.2(a)(1). The agreement... such Federal law and of the consequences of a violation of such law, both to the recipient and to...

45 CFR 1640.3 - Contractual agreement.

Code of Federal Regulations, 2012 CFR

2012-10-01

... OF FEDERAL LAW TO LSC RECIPIENTS § 1640.3 Contractual agreement. As a condition of receiving LSC... respect to its LSC funds, it will be subject to the Federal laws listed in § 1640.2(a)(1). The agreement... such Federal law and of the consequences of a violation of such law, both to the recipient and to...

45 CFR Appendix to Part 1626 - Alien Eligibility for Representation by LSC Programs

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 4 2011-10-01 2011-10-01 false Alien Eligibility for Representation by LSC... SERVICES CORPORATION RESTRICTIONS ON LEGAL ASSISTANCE TO ALIENS Pt. 1626, App. Appendix to Part 1626—Alien Eligibility for Representation by LSC Programs Alien Eligibility for Representation by LSC Programs Alien...

45 CFR Appendix to Part 1626 - Alien Eligibility for Representation by LSC Programs

Code of Federal Regulations, 2012 CFR

2012-10-01

... 45 Public Welfare 4 2012-10-01 2012-10-01 false Alien Eligibility for Representation by LSC... SERVICES CORPORATION RESTRICTIONS ON LEGAL ASSISTANCE TO ALIENS Pt. 1626, App. Appendix to Part 1626—Alien Eligibility for Representation by LSC Programs Alien Eligibility for Representation by LSC Programs Alien...

45 CFR Appendix to Part 1626 - Alien Eligibility for Representation by LSC Programs

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 4 2010-10-01 2010-10-01 false Alien Eligibility for Representation by LSC... SERVICES CORPORATION RESTRICTIONS ON LEGAL ASSISTANCE TO ALIENS Pt. 1626, App. Appendix to Part 1626—Alien Eligibility for Representation by LSC Programs Alien Eligibility for Representation by LSC Programs Alien...

45 CFR Appendix to Part 1626 - Alien Eligibility for Representation by LSC Programs

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 4 2013-10-01 2013-10-01 false Alien Eligibility for Representation by LSC... SERVICES CORPORATION RESTRICTIONS ON LEGAL ASSISTANCE TO ALIENS Pt. 1626, App. Appendix to Part 1626—Alien Eligibility for Representation by LSC Programs Alien Eligibility for Representation by LSC Programs Alien...

45 CFR 1640.2 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Regulations Relating to Public Welfare (Continued) LEGAL SERVICES CORPORATION APPLICATION OF FEDERAL LAW TO LSC RECIPIENTS § 1640.2 Definitions. (a)(1) Federal law relating to the proper use of Federal funds... the laws listed in paragraph (a)(1) of this section, LSC shall be considered a Federal agency and a...

45 CFR 1640.2 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Regulations Relating to Public Welfare (Continued) LEGAL SERVICES CORPORATION APPLICATION OF FEDERAL LAW TO LSC RECIPIENTS § 1640.2 Definitions. (a)(1) Federal law relating to the proper use of Federal funds... the laws listed in paragraph (a)(1) of this section, LSC shall be considered a Federal agency and a...

45 CFR 1640.2 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Regulations Relating to Public Welfare (Continued) LEGAL SERVICES CORPORATION APPLICATION OF FEDERAL LAW TO LSC RECIPIENTS § 1640.2 Definitions. (a)(1) Federal law relating to the proper use of Federal funds... the laws listed in paragraph (a)(1) of this section, LSC shall be considered a Federal agency and a...

45 CFR 1640.2 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Regulations Relating to Public Welfare (Continued) LEGAL SERVICES CORPORATION APPLICATION OF FEDERAL LAW TO LSC RECIPIENTS § 1640.2 Definitions. (a)(1) Federal law relating to the proper use of Federal funds... the laws listed in paragraph (a)(1) of this section, LSC shall be considered a Federal agency and a...

45 CFR 1640.3 - Contractual agreement.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 45 Public Welfare 4 2014-10-01 2014-10-01 false Contractual agreement. 1640.3 Section 1640.3... OF FEDERAL LAW TO LSC RECIPIENTS § 1640.3 Contractual agreement. As a condition of receiving LSC funds, a recipient must enter into a written contractual agreement with the Corporation that, with...

45 CFR 1640.2 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Regulations Relating to Public Welfare (Continued) LEGAL SERVICES CORPORATION APPLICATION OF FEDERAL LAW TO LSC RECIPIENTS § 1640.2 Definitions. (a)(1) Federal law relating to the proper use of Federal funds... the laws listed in paragraph (a)(1) of this section, LSC shall be considered a Federal agency and a...

78 FR 19326 - Notice of Funding Availability for Calendar Year 2014 Competitive Grant Funds Request for...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-29

... LEGAL SERVICES CORPORATION Notice of Funding Availability for Calendar Year 2014 Competitive Grant Funds Request for Proposals: 2014 Competitive Grant Funds AGENCY: Legal Services Corporation. ACTION: Notice. SUMMARY: The Legal Services Corporation (LSC) is the national organization charged with...

78 FR 30338 - Notice of Funding Availability for Calendar Year 2013 Grant Funds; Request for Applications: 2013...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-22

... LEGAL SERVICES CORPORATION Notice of Funding Availability for Calendar Year 2013 Grant Funds...: Legal Services Corporation. ACTION: Notice. SUMMARY: The Legal Services Corporation (LSC) is the national organization charged with administering federal funds provided for civil legal services to low...

78 FR 30339 - Notice of Funding Availability for Calendar Year 2013 Grant Funds; Request for Applications: 2013...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-22

... LEGAL SERVICES CORPORATION Notice of Funding Availability for Calendar Year 2013 Grant Funds; Request for Applications: 2013 Disaster Relief Emergency Grant Funds AGENCY: Legal Services Corporation. ACTION: Notice. SUMMARY: The Legal Services Corporation (LSC) is the national organization charged with...

45 CFR 1610.4 - Authorized use of non-LSC funds.

Code of Federal Regulations, 2010 CFR

2010-10-01

... activity prohibited by or inconsistent with Section 504. (c) A recipient may receive private funds and use.... (a) A recipient may receive tribal funds and expend them in accordance with the specific purposes for which the tribal funds were provided. (b) A recipient may receive public or IOLTA funds and use them in...

78 FR 78398 - Notice and Request for Comments: LSC merger of the migrant service areas in Texas, Arkansas...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-26

... mission of LSC is to promote equal access to justice and to provide funding for high-quality civil legal... legal needs of migrants or seasonal farm workers and implement recommended approaches to meet their special legal needs. 42 U.S.C. 2996f(h). The regional approach to migrant delivery accomplished by merging...

75 FR 12802 - Notice of Availability of Calendar Year 2011 Competitive Grant Funds

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-17

... LEGAL SERVICES CORPORATION Notice of Availability of Calendar Year 2011 Competitive Grant Funds AGENCY: Legal Services Corporation. ACTION: Solicitation for Proposals for the Provision of Civil Legal Services. SUMMARY: The Legal Services Corporation (LSC) is the national organization charged with...

77 FR 19738 - Notice of Availability of Calendar Year 2013 Competitive Grant Funds

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-02

... LEGAL SERVICES CORPORATION Notice of Availability of Calendar Year 2013 Competitive Grant Funds AGENCY: Legal Services Corporation. ACTION: Solicitation for proposals for the provision of civil legal services. SUMMARY: The Legal Services Corporation (LSC) is the national organization charged with...

76 FR 1642 - Notice of Availability of Calendar Year 2011 Competitive Grant Funds

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-11

... LEGAL SERVICES CORPORATION Notice of Availability of Calendar Year 2011 Competitive Grant Funds AGENCY: Legal Services Corporation. ACTION: Solicitation for Proposals for the Provision of Civil Legal Services in Louisiana for service area LA-1. SUMMARY: The Legal Services Corporation (LSC) is the national...

77 FR 46995 - Termination, Limited Reductions in Funding, and Debarment Procedures; Recompetition; Enforcement...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-07

... LEGAL SERVICES CORPORATION 45 CFR Parts 1606, 1618, and 1623 Termination, Limited Reductions in...- cost procedures (45 CFR part 1630). LSC has also adopted grant termination procedures (45 CFR part 1606... reduce a recipient's funding by less than five percent without using the 1606 termination procedures...

45 CFR 1628.3 - Policy.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 4 2013-10-01 2013-10-01 false Policy. 1628.3 Section 1628.3 Public Welfare... Policy. (a) Recipients are permitted to retain from one fiscal year to the next LSC fund balances up to... Corporation are not subject to the fund balance policy set forth in this part. Revenue and expenses relating...

45 CFR 1611.2 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... relevant to the client's legal problem(s) and counseling the client on the relevant law and/or suggested... supported with LSC funds from a recipient. The term does not include a group, corporation or association. (d...

Where the Rubber Meets the Road: The Role of Collegiality and Normative Science in Our Profession

ERIC Educational Resources Information Center

Plazek, David J.

2010-01-01

Lyndon State College's (LSC) participation in the America's Future Initiative on the U.S. national debt, in association with Public Agenda, began with a grant application for funding to participate. After being awarded funding, as the sole political scientist, I was selected with approval by the administration to attend the September 11 to 13,…

78 FR 25483 - Notice of Proposed Revisions for the LSC Grant Assurances for Calendar Year 2014 Funding

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-01

.../sites/default/files/Grants/ReferenceMaterials/2014-GrantAssurances-Proposed.pdf . DATES: All comments...-GrantAssurances-Proposed.pdf . Interested parties are requested to provide comments concerning the...

76 FR 56482 - Sunshine Act Meeting of the Operations & Regulations Committee of the LSC Board of Directors

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-13

... and Congress statutory changes concerning replacement of decennial census poverty data in the... poverty data, phasing in the first redistribution over two years, and redistributing funds triennially...

Analyzing luminescent solar concentrators with front-facing photovoltaic cells using weighted Monte Carlo ray tracing

NASA Astrophysics Data System (ADS)

Woei Leow, Shin; Corrado, Carley; Osborn, Melissa; Isaacson, Michael; Alers, Glenn; Carter, Sue A.

2013-06-01

Luminescent solar concentrators (LSC) collect ambient light from a broad range of angles and concentrate the captured light onto photovoltaic (PV) cells. LSCs with front-facing cells collect direct and indirect sunlight ensuring a gain factor greater than one. The flexible placement and percentage coverage of PV cells on the LSC panel allow for layout adjustments to be made in order to balance re-absorption losses and the level of light concentration desired. A weighted Monte Carlo ray tracing program was developed to study the transport of photons and loss mechanisms in the LSC to aid in design optimization. The program imports measured absorption/emission spectra of an organic luminescent dye (LR305), the transmission coefficient, and refractive index of acrylic as parameters that describe the system. Simulations suggest that for LR305, 8-10 cm of luminescent material surrounding the PV cell yields the highest increase in power gain per unit area of LSC added, thereby determining the ideal spacing between PV cells in the panel. For rectangular PV cells, results indicate that for each centimeter of PV cell width, an additional increase of 0.15 mm to the waveguide thickness is required to efficiently transport photon collected by the LSC to the PV cell with minimal loss.

45 CFR 1643.1 - Purpose.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 45 Public Welfare 4 2014-10-01 2014-10-01 false Purpose. 1643.1 Section 1643.1 Public Welfare Regulations Relating to Public Welfare (Continued) LEGAL SERVICES CORPORATION RESTRICTION ON ASSISTED SUICIDE... any LSC funds for any assisted suicide, euthanasia or mercy killing activities prohibited by this part. ...

45 CFR 1643.1 - Purpose.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 4 2011-10-01 2011-10-01 false Purpose. 1643.1 Section 1643.1 Public Welfare Regulations Relating to Public Welfare (Continued) LEGAL SERVICES CORPORATION RESTRICTION ON ASSISTED SUICIDE... any LSC funds for any assisted suicide, euthanasia or mercy killing activities prohibited by this part. ...

45 CFR 1643.1 - Purpose.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 4 2010-10-01 2010-10-01 false Purpose. 1643.1 Section 1643.1 Public Welfare Regulations Relating to Public Welfare (Continued) LEGAL SERVICES CORPORATION RESTRICTION ON ASSISTED SUICIDE... any LSC funds for any assisted suicide, euthanasia or mercy killing activities prohibited by this part. ...

45 CFR 1643.1 - Purpose.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 4 2013-10-01 2013-10-01 false Purpose. 1643.1 Section 1643.1 Public Welfare Regulations Relating to Public Welfare (Continued) LEGAL SERVICES CORPORATION RESTRICTION ON ASSISTED SUICIDE... any LSC funds for any assisted suicide, euthanasia or mercy killing activities prohibited by this part. ...

45 CFR 1643.1 - Purpose.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 45 Public Welfare 4 2012-10-01 2012-10-01 false Purpose. 1643.1 Section 1643.1 Public Welfare Regulations Relating to Public Welfare (Continued) LEGAL SERVICES CORPORATION RESTRICTION ON ASSISTED SUICIDE... any LSC funds for any assisted suicide, euthanasia or mercy killing activities prohibited by this part. ...

45 CFR 1630.12 - Applicability to derivative income.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 4 2011-10-01 2011-10-01 false Applicability to derivative income. 1630.12... CORPORATION COST STANDARDS AND PROCEDURES § 1630.12 Applicability to derivative income. (a) Derivative income... activity. (b) Derivative income which is allocated to the LSC fund in accordance with paragraph (a) of this...

The conserved upstream region of lscB/C determines expression of different levansucrase genes in plant pathogen Pseudomonas syringae

PubMed Central

2014-01-01

Background Pseudomonas syringae pv. glycinea PG4180 is an opportunistic plant pathogen which causes bacterial blight of soybean plants. It produces the exopolysaccharide levan by the enzyme levansucrase. Levansucrase has three gene copies in PG4180, two of which, lscB and lscC, are expressed while the third, lscA, is cryptic. Previously, nucleotide sequence alignments of lscB/C variants in various P. syringae showed that a ~450-bp phage-associated promoter element (PAPE) including the first 48 nucleotides of the ORF is absent in lscA. Results Herein, we tested whether this upstream region is responsible for the expression of lscB/C and lscA. Initially, the transcriptional start site for lscB/C was determined. A fusion of the PAPE with the ORF of lscA (lscB UpN A) was generated and introduced to a levan-negative mutant of PG4180. Additionally, fusions comprising of the non-coding part of the upstream region of lscB with lscA (lscB Up A) or the upstream region of lscA with lscB (lscA Up B) were generated. Transformants harboring the lscB UpN A or the lscB Up A fusion, respectively, showed levan formation while the transformant carrying lscA Up B did not. qRT-PCR and Western blot analyses showed that lscB UpN A had an expression similar to lscB while lscB Up A had a lower expression. Accuracy of protein fusions was confirmed by MALDI-TOF peptide fingerprinting. Conclusions Our data suggested that the upstream sequence of lscB is essential for expression of levansucrase while the N-terminus of LscB mediates an enhanced expression. In contrast, the upstream region of lscA does not lead to expression of lscB. We propose that lscA might be an ancestral levansucrase variant upstream of which the PAPE got inserted by potentially phage-mediated transposition events leading to expression of levansucrase in P. syringae. PMID:24670199

45 CFR 1627.4 - Membership fees or dues.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 4 2010-10-01 2010-10-01 false Membership fees or dues. 1627.4 Section 1627.4... AND MEMBERSHIP FEES OR DUES § 1627.4 Membership fees or dues. (a) LSC funds may not be used to pay membership fees or dues to any private or nonprofit organization, whether on behalf of a recipient or an...

Genetically distinct leukemic stem cells in human CD34− acute myeloid leukemia are arrested at a hemopoietic precursor-like stage

PubMed Central

Quek, Lynn; Garnett, Catherine; Karamitros, Dimitris; Stoilova, Bilyana; Doondeea, Jessica; Kennedy, Alison; Metzner, Marlen; Ivey, Adam; Sternberg, Alexander; Hunter, Hannah; Price, Andrew; Virgo, Paul; Grimwade, David; Freeman, Sylvie; Russell, Nigel; Mead, Adam

2016-01-01

Our understanding of the perturbation of normal cellular differentiation hierarchies to create tumor-propagating stem cell populations is incomplete. In human acute myeloid leukemia (AML), current models suggest transformation creates leukemic stem cell (LSC) populations arrested at a progenitor-like stage expressing cell surface CD34. We show that in ∼25% of AML, with a distinct genetic mutation pattern where >98% of cells are CD34−, there are multiple, nonhierarchically arranged CD34+ and CD34− LSC populations. Within CD34− and CD34+ LSC–containing populations, LSC frequencies are similar; there are shared clonal structures and near-identical transcriptional signatures. CD34− LSCs have disordered global transcription profiles, but these profiles are enriched for transcriptional signatures of normal CD34− mature granulocyte–macrophage precursors, downstream of progenitors. But unlike mature precursors, LSCs express multiple normal stem cell transcriptional regulators previously implicated in LSC function. This suggests a new refined model of the relationship between LSCs and normal hemopoiesis in which the nature of genetic/epigenetic changes determines the disordered transcriptional program, resulting in LSC differentiation arrest at stages that are most like either progenitor or precursor stages of hemopoiesis. PMID:27377587

Pyrotechnic shock: A literature survey of the Linear Shaped Charge (LSC)

NASA Technical Reports Server (NTRS)

Smith, J. L.

1984-01-01

Linear shaped charge (LSC) literature for the past 20 years is reviewed. The following topics are discussed: (1) LSC configuration; (2) LSC usage; (3) LSC induced pyroshock; (4) simulated pyrotechnic testing; (5) actual pyrotechnic testing; (6) data collection methods; (7) data analysis techniques; (8) shock reduction methods; and (9) design criteria. Although no new discoveries have been made in LSC research, charge shapes are improved to allow better cutting performance, testing instrumentation is refined, and some new explosives, for use in LSC, are formulated.

Clinical and laboratory features of systemic sclerosis complicated with localized scleroderma.

PubMed

Toki, Sayaka; Motegi, Sei-ichiro; Yamada, Kazuya; Uchiyama, Akihiko; Kanai, Sahori; Yamanaka, Masayoshi; Ishikawa, Osamu

2015-03-01

Localized scleroderma (LSc) primarily affects skin, whereas systemic sclerosis (SSc) affects skin and various internal organs. LSc and SSc are considered to be basically different diseases, and there is no transition between them. However, LSc and SSc have several common characteristics, including endothelial cell dysfunction, immune activation, and excess fibrosis of the skin, and there exist several SSc cases complicated with LSc during the course of SSc. Clinical and laboratory characteristics of SSc patients with LSc remain unclear. We investigated the clinical and laboratory features of 8 SSc patients with LSc among 220 SSc patients (3.6%). The types of LSc included plaque (5/8), guttate (2/8), and linear type (1/8). All cases were diagnosed as having SSc within 5 years before or after the appearance of LSc. In three cases of SSc with LSc (37.5%), LSc skin lesions preceded clinical symptoms of SSc. Young age, negative antinuclear antibody, and positive anti-RNA polymerase III antibody were significantly prevalent in SSc patients with LSc. The positivity of anticentromere antibody tended to be prevalent in SSc patients without LSc. No significant difference in the frequency of complications, such as interstitial lung disease, reflux esophagitis, and pulmonary artery hypertension, was observed. The awareness of these characteristic of SSc with LSc are essential to establish an early diagnosis and treatment. © 2015 Japanese Dermatological Association.

Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells

PubMed Central

Somervaille, Tim C. P.; Matheny, Christina J.; Spencer, Gary J.; Iwasaki, Masayuki; Rinn, John L.; Witten, Daniela M.; Chang, Howard Y.; Shurtleff, Sheila A.; Downing, James R.; Cleary, Michael L.

2009-01-01

Summary The genetic programs that promote retention of self-renewing leukemia stem cells (LSCs) at the apex of cellular hierarchies in acute myeloid leukemia (AML) are not known. In a mouse model of human AML, LSCs exhibit variable frequencies that correlate with the initiating MLL oncogene and are maintained in a self-renewing state by a transcriptional sub-program more akin to that of embryonic stem cells (ESCs) than adult stem cells. The transcription/chromatin regulatory factors Myb, Hmgb3 and Cbx5 are critical components of the program and suffice for Hoxa/Meis-independent immortalization of myeloid progenitors when co-expressed, establishing the cooperative and essential role of an ESC-like LSC maintenance program ancillary to the leukemia initiating MLL/Hox/Meis program. Enriched expression of LSC maintenance and ESC-like program genes in normal myeloid progenitors and poor prognosis human malignancies links the frequency of aberrantly self-renewing progenitor-like cancer stem cells to prognosis in human cancer. PMID:19200802

Oxygen surface exchange kinetics and stability of (La,Sr) 2 CoO 4±δ/La 1-xSr xMO 3-δ (M = Co and Fe) hetero-interfaces at intermediate temperatures

DOE PAGES

Lee, Dongkyu; Lee, Yueh-Lin; Hong, Wesley T.; ...

2014-11-13

Heterostructured oxide interfaces created by decorating Ruddlesden-Popper phases (A2BO4) or perovskites on perovskites have shown not only pronounced cation segregation at the interface and in the A2BO4 structure but also much enhanced kinetics for oxygen electrocatalysis at elevated temperatures. In this study, we report and compare the time-dependent surface exchange kinetics and stability of (La 0.5Sr 0.5) 2CoO 4 -decorated (LSC 214) La 0.6Sr 0.4Co 0.2Fe 0.8O 3-δ (LSCF 113) and La 0.8Sr 0.2CoO 3-δ (LSC 113) thin films. While LSC 214 decoration on LSC 113 greatly reduced the degradation in the surface exchange kinetics as a function of timemore » relative to LSC 113, LSCF 113 with LSC 214 coverage showed comparable surface exchange kinetics and stability to LSCF 113. This difference can be explained by greater surface stability of LSCF 113 than LSC 113 under testing conditions, and that LSC 214 decoration on LSC 113 reduced the decomposition of LSC 113 to form secondary phases that impedes oxygen exchange kinetics, and thus resulted in enhanced stability. This hypothesis is supported by the observations that annealing at 550 °C led to the formation of Sr-rich secondary particles on LSC 113 while no such particles were observed on LSCF 113. Density functional theory (DFT) computation provides further support, which revealed greater capacity of surface Sr segregation for LSCF 113 having SrO termination than LSC 113 having (La 0.25Sr 0.75)O termination for the experimental conditions, and lower energy gain to move Sr from LSCF 113 into LSC 214 relative to the LSC 214-LSC 113 system.« less

Simulation of a cascaded longitudinal space charge amplifier for coherent radiation generation

DOE PAGES

Halavanau, A.; Piot, P.

2016-03-03

Longitudinal space charge (LSC) effects are generally considered as harmful in free-electron lasers as they can seed unfavorable energy modulations that can result in density modulations with associated emittance dilution. It was pointed out, however, that such \\micro-bunching instabilities" could be potentially useful to support the generation of broadband coherent radiation. Therefore there has been an increasing interest in devising accelerator beam lines capable of controlling LSC induced density modulations. In the present paper we augment these previous investigations by combining a grid-less space charge algorithm with the popular particle-tracking program elegant. This high-fidelity model of the space charge ismore » used to benchmark conventional LSC models. We then employ the developed model to optimize the performance of a cascaded longitudinal space charge amplifier using beam parameters comparable to the ones achievable at Fermilab Accelerator Science & Technology (FAST) facility currently under commissioning at Fermilab.« less

Systemic sclerosis complicated with localized scleroderma-like lesions induced by Köbner phenomenon.

PubMed

Saigusa, Ryosuke; Asano, Yoshihide; Yamashita, Takashi; Takahashi, Takehiro; Nakamura, Kouki; Miura, Shunsuke; Ichimura, Yohei; Toyama, Tetsuo; Taniguchi, Takashi; Sumida, Hayakazu; Tamaki, Zenshiro; Miyazaki, Miki; Yoshizaki, Ayumi; Sato, Shinichi

2018-03-01

Scleroderma is a chronic disease of unknown etiology characterized by skin fibrosis and is divided into two clinical entities: systemic sclerosis (SSc) and localized scleroderma (LSc). In general, LSc is rarely complicated with SSc, but a certain portion of SSc patients manifests bilateral symmetric LSc-like lesions on the trunk and extremities. We investigated SSc patients with LSc-like lesions to clarify the underlying pathophysiology. Nine SSc cases complicated with LSc-like lesions were clinically and histologically characterized. SSc patients with LSc-like lesions exhibited multiple progressive hyper- and/or hypo-pigmented plaques with mild sclerosis symmetrically distributed on the trunk and extremities, especially abdominal region. In histological assessment, epidermal IL-1α expression was elevated in both forearms and LSc-like lesions of these patients to a greater extent than in forearms of control patients (SSc patients without LSc-like lesions). Of note, the infiltration and degranulation of mast cells were evident throughout the dermis of LSc-like lesions, while detectable to a lesser extent in forearms of SSc patients with LSc-like lesions and control patients. The epidermis of SSc patients with LSc-like lesions seems to possess an inflammatory phenotype, leading to the activation of mast cells in the dermis of mechanically stressed skin. Köbner phenomenon may be involved in the induction of LSc-like lesions in a certain subset of SSc. Copyright © 2017 Japanese Society for Investigative Dermatology. Published by Elsevier B.V. All rights reserved.

Vaginal sacrospinous colpopexy and laparoscopic sacral colpopexy for vaginal vault prolapse.

PubMed

Marcickiewicz, J; Kjöllesdal, M; Engh, M Ellström; Eklind, S; Axén, C; Brännström, M; Stjerndahl, J-H

2007-01-01

Vaginal sacrospinous colpopexy (VSC) and laparoscopic sacral colpopexy (LSC) both correct vault prolapse. The present study compares the perioperative course and long-term results of VSC and LSC. This retrospective study of post-hysterectomy vault prolapse involved 111 patients operated with either VSC (n=51) or LSC (n=60). The median time for the postoperative follow-up visit was 33.6 (range: 13-60) months for the LSC group and 38.4 (range: 7-108) months for the VSC group. Prolapse grade as well as the patient's satisfaction was recorded at the follow-up visit. Operation time was significantly shorter in the VSC group (median: 62 min) compared to the LSC group (median: 129 min). The rate of perioperative complications was low in both groups. There were 3 laparotomies in the LSC group, due to perioperative complications. The inpatients days were similar, with 3.7 days (1-18) and 4.0 days (2-21) in the VSC and the LSC group, respectively. Surgery for the recurrence of vault prolapse at any time before the follow-up visit did not occur in the VSC group, but occurred in 7 patients in the LSC group. At the follow-up visit, there was no recurrence of vault prolapse in either group. The subjective success rate was 82% in the VSC and 78% in the LSC group. This study indicates that VSC and LSC are two equally effective surgical procedures to correct vaginal vault prolapse, but the LSC technique requires a longer operating time.

Utilizing Diffuse Reflection to Increase the Efficiency of Luminescent Solar Concentrators

NASA Astrophysics Data System (ADS)

Bowser, Seth; Weible, Seth; Solomon, Joel; Schrecengost, Jonathan; Wittmershaus, Bruce

A luminescent solar concentrator (LSC) consists of a high index solid plate containing a fluorescent material that converts sunlight into fluorescence. Utilizing total internal reflection, the LSC collects and concentrates the fluorescence at the plate's edges where it is converted into electricity via photovoltaic solar cells. The lower production costs of LSCs make them an attractive alternative to photovoltaic solar cells. To optimize an LSC's efficiency, a white diffusive surface (background) is positioned behind it. The background allows sunlight transmitted in the first pass to be reflected back through the LSC providing a second chance for absorption. Our research examines how the LSC's performance is affected by changing the distance between the white background and the LSC. An automated linear motion apparatus was engineered to precisely measure this distance and the LSC's electrical current, simultaneously. LSC plates, with and without the presence of fluorescent material and in an isolated environment, showed a maximum current at a distance greater than zero. Further experimentation has proved that the optimal distance results from the background's optical properties and how the reflected light enters the LSC. This material is based upon work supported by the National Science Foundation under Grant Number NSF-ECCS-1306157.

CD45RA, a specific marker for leukaemia stem cell sub-populations in acute myeloid leukaemia.

PubMed

Kersten, Bas; Valkering, Matthijs; Wouters, Rolf; van Amerongen, Rosa; Hanekamp, Diana; Kwidama, Zinia; Valk, Peter; Ossenkoppele, Gert; Zeijlemaker, Wendelien; Kaspers, Gertjan; Cloos, Jacqueline; Schuurhuis, Gerrit J

2016-04-01

Chemotherapy resistant leukaemic stem cells (LSC) are thought to be responsible for relapses after therapy in acute myeloid leukaemia (AML). Flow cytometry can discriminate CD34(+) CD38(-) LSC and normal haematopoietic stem cells (HSC) by using aberrant expression of markers and scatter properties. However, not all LSC can be identified using currently available markers, so new markers are needed. CD45RA is expressed on leukaemic cells in the majority of AML patients. We investigated the potency of CD45RA to specifically identify LSC and HSC and improve LSC quantification. Compared to our best other markers (CLL-1, also termed CLEC12A, CD33 and CD123), CD45RA was the most reliable marker. Patients with high percentages (>90%) of CD45RA on CD34(+) CD38(-) LSC have 1·69-fold higher scatter values compared to HSC (P < 0·001), indicating a more mature CD34(+) CD38(-) phenotype. Patients with low (<10%) or intermediate (10-90%) CD45RA expression on LSC showed no significant differences to HSC (1·12- and 1·15-fold higher, P = 0·31 and P = 0·44, respectively). CD45RA-positive LSC tended to represent more favourable cytogenetic/molecular markers. In conclusion, CD45RA contributes to more accurate LSC detection and is recommended for inclusion in stem cell tracking panels. CD45RA may contribute to define new LSC-specific therapies and to monitor effects of anti-LSC treatment. © 2016 John Wiley & Sons Ltd.

75 FR 80850 - Development of Strategic Plan 2011-2015

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-23

... intended for use as LSC embarks on its planning process. LSC anticipates publishing a draft Strategic Plan... process to develop a Strategic Plan for the years 2011-2015. Toward that end, LSC is soliciting... strategic planning efforts. In addition, Among other sources, LSC is considering the guidance provided by...

The UN Commission on Life Saving Commodities 3 years on: global progress update and results of a multicountry assessment.

PubMed

Pronyk, Paul M; Nemser, Bennett; Maliqi, Blerta; Springstubb, Nora; Sera, Diana; Karimov, Rouslan; Katwan, Elizabeth; Walter, Benedicte; Bijleveld, Pascal

2016-04-01

In September, 2012, the UN Commission on Life Saving Commodities (UNCoLSC) outlined a plan to expand availability and access to 13 life saving commodities. We profile global and country progress against these recommendations between 2012 and 2015. For 12 countries in sub-Saharan Africa that were off-track to achieve the Millennium Development Goals for maternal and child survival, we reviewed key documents and reference data, and conducted interviews with ministry staff and partners to assess the status of the UNCoLSC recommendations. The RMNCH fund provided short-term catalytic financing to support country plans to advance the commodity agenda, with activities coded by UNCoLSC recommendation. Our network of technical resource teams identified, addressed, and monitored progress against cross-cutting commodity-related challenges that needed coordinated global action. In 2014 and 2015, child and maternal health commodities had fewer bottlenecks than reproductive and neonatal commodities. Common bottlenecks included regulatory challenges (ten of 12 countries); poor quality assurance (11 of 12 countries); insufficient staff training (more than half of facilities on average); and weak supply chains systems (11 of 12 countries), with stock-outs of priority commodities in about 40% of facilities on average. The RMNCH fund committed US$175·7 million to 19 countries to support strategies addressing crucial gaps. $68·2 million (39·0%) of the funds supported systems-strengthening interventions with the remainder split across reproductive, maternal, newborn, and child health. Health worker training ($88·6 million, 50·4%), supply chain ($53·3 million, 30·0%), and demand generation ($21·1 million, 12·0%) were the major topics of focus. All priority commodities are now listed in the WHO Essential Medicines List; appropriate price reductions were secured; quality manufacturing was improved; a fast-track registration mechanism for prequalified products was established; and methods were developed for advocacy, quantification, demand generation, supply chain, and provider training. Slower progress was evident around regulatory harmonisation and quality assurance. Much work is needed to achieve full implementation of the UNCoLSC recommendations. Coordinated efforts to secure price reductions beyond the 13 commodities and improve regulatory efficiency, quality, and supply chains are still needed alongside broader dissemination of work products. Governments of Norway (NORAD) and the UK (DFID). Copyright © 2015 World Health Organization; licensee Elsevier. This is an Open Access article published without any waiver of WHO's privileges and immunities under international law, convention, or agreement. This Article should not be reproduced for use in association with the promotion of commercial products, services, or any legal entity. There should be no suggestion that WHO endorses any specific organisation or products. The use of the WHO logo is not permitted. This notice should be preserved along with the Article's original URL.

Comparative Toxicity of Eight Oil Dispersants, Louisiana Sweet Crude Oil (LSC) and Chemically Dispersed LSC to Two Aquatic Test Species

EPA Science Inventory

This study describes the acute toxicity of eight commercial oil dispersants, Louisiana sweet crude oil (LSC), and chemically dispersed LSC. The approach utilized consistent test methodologies within a single laboratory in assessing the relative acute toxicity of the eight dispers...

Concise review: preleukemic stem cells: molecular biology and clinical implications of the precursors to leukemia stem cells.

PubMed

Pandolfi, Ashley; Barreyro, Laura; Steidl, Ulrich

2013-02-01

Recent experimental evidence has shown that acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) arise from transformed immature hematopoietic cells following the accumulation of multiple stepwise genetic and epigenetic changes in hematopoietic stem cells and committed progenitors. The series of transforming events initially gives rise to preleukemic stem cells (pre-LSC), preceding the formation of fully transformed leukemia stem cells (LSC). Despite the established use of poly-chemotherapy, relapse continues to be the most common cause of death in AML and MDS. The therapeutic elimination of all LSC, as well as pre-LSC, which provide a silent reservoir for the re-formation of LSC, will be essential for achieving lasting cures. Conventional sequencing and next-generation genome sequencing have allowed us to describe many of the recurrent mutations in the bulk cell populations in AML and MDS, and recent work has also focused on identifying the initial molecular changes contributing to leukemogenesis. Here we review recent and ongoing advances in understanding the roles of pre-LSC, and the aberrations that lead to pre-LSC formation and subsequent LSC transformation.

An Evaluation of the ELNP e-Learning Quality Assurance Program: Perspectives of Gap Analysis and Innovation Diffusion

ERIC Educational Resources Information Center

Chen, Ming-Puu

2009-01-01

The purpose of this study was to examine the appropriateness of a nationwide quality assurance framework for e-learning from participants' perspectives. Two types of quality evaluation programs were examined in this study, including the e-Learning Service Certification program (eLSC) and the e-Learning Courseware Certification program (eLCC). Gap…

Community-based evaluation of laparoscopic versus open simple closure of perforated peptic ulcers.

PubMed

Kuwabara, Kazuaki; Matsuda, Shinya; Fushimi, Kiyohide; Ishikawa, Koichi B; Horiguchi, Hiromasa; Fujimori, Kenji

2011-11-01

Several studies have advocated laparoscopic simple closure (LSC) as the treatment of choice for perforated peptic ulcer disease (PUD). However, there has been no comprehensive community-based evaluation of the advantages of using LSC over open simple closure (OSC). Using an administrative database, we evaluated LSC versus OSC for patients with perforated ulcers. From 6,334 patients with perforated ulcers, we identified 2,909 simple closure cases between 2006 and 2010. Study variables were demographics, mortality, co-morbidities, complications, ulcer location, surgical timing, blood transfusion, postoperative ventilation, operating room (OR) time, time to resumption of oral food intake, length of stay (LOS), and total charges. After matching patient baseline variables between OSC and LSC, we performed multivariate analyses to assess the impacts of LSC on mortality, complications, and ventilation administration. A total of 2,073 OSC cases and 836 LSC cases were identified in 670 hospitals. Younger age, duodenal ulcer, and pre-existing PUD were indicators for selection of LSC. Matching analysis indicated a correlation between LSC and lower mortality, less frequent postoperative and overall blood transfusion, shorter LOS, earlier return to oral intake, and longer OR time. There was no difference between OSC and LSC in complication rate or mortality. Longer OR time was correlated with a higher complication rate and the need for ventilation, the latter of which was independently associated with an increase in mortality. Because longer OR time was associated with more frequent complications and ventilation, surgeons should obtain the skills and strategies necessary to accomplish LSC without extending OR time improperly.

Systems tunnel linear shaped charge lightning strike

NASA Technical Reports Server (NTRS)

Cook, M.

1989-01-01

Simulated lightning strike testing of the systems tunnel linear shaped charge (LSC) was performed at the Thiokol Lightning Test Complex in Wendover, Utah, on 23 Jun. 1989. The test article consisted of a 160-in. section of the LSC enclosed within a section of the systems tunnel. The systems tunnel was bonded to a section of a solid rocket motor case. All test article components were full scale. The systems tunnel cover of the test article was subjected to three discharges (each discharge was over a different grounding strap) from the high-current generator. The LSC did not detonate. All three grounding straps debonded and violently struck the LSC through the openings in the systems tunnel floor plates. The LSC copper surface was discolored around the areas of grounding strap impact, and arcing occurred at the LSC clamps and LSC ends. This test verified that the present flight configuration of the redesigned solid rocket motor systems tunnel, when subjected to simulated lightning strikes with peak current levels within 71 percent of the worst-case lightning strike condition of NSTS-07636, is adequate to prevent LSC ignition. It is therefore recommended that the design remain unchanged.

Effects of variables upon pyrotechnically induced shock response spectra

NASA Technical Reports Server (NTRS)

Smith, J. L.

1986-01-01

Throughout the aerospace industry, large variations of 50 percent (6 dB) or more are continually noted for linear shaped charge (LSC) generated shock response spectra (SRS) from flight data (from the exact same location on different flights) and from plate tests (side by side measurements on the same test). A research program was developed to investigate causes of these large SRS variations. A series of ball drop calibration tests to verify calibration of accelerometers and a series of plate tests to investigate charge and assembly variables were performed. The resulting data were analyzed to determine if and to what degree manufacturing and assembly variables, distance from the shock source, data acquisition instrumentation, and shock energy propagation affect the SRS. LSC variables consisted of coreload, standoff, and apex angle. The assembly variable was the torque on the LSC holder. Other variables were distance from source of accelerometers, accelerometer mounting methods, and joint effects. Results indicated that LSC variables did not affect SRS as long as the plate was severed. Accelerometers mounted on mounting blocks showed significantly lower levels above 5000 Hz. Lap joints did not affect SRS levels. The test plate was mounted in an almost free-free state; therefore, distance from the source did not affect the SRS. Several varieties and brands of accelerometers were used, and all but one demonstrated very large variations in SRS.

Comparison of a row-column speller vs. a novel lateral single-character speller: assessment of BCI for severe motor disabled patients.

PubMed

Pires, Gabriel; Nunes, Urbano; Castelo-Branco, Miguel

2012-06-01

Non-invasive brain-computer interface (BCI) based on electroencephalography (EEG) offers a new communication channel for people suffering from severe motor disorders. This paper presents a novel P300-based speller called lateral single-character (LSC). The LSC performance is compared to that of the standard row-column (RC) speller. We developed LSC, a single-character paradigm comprising all letters of the alphabet following an event strategy that significantly reduces the time for symbol selection, and explores the intrinsic hemispheric asymmetries in visual perception to improve the performance of the BCI. RC and LSC paradigms were tested by 10 able-bodied participants, seven participants with amyotrophic lateral sclerosis (ALS), five participants with cerebral palsy (CP), one participant with Duchenne muscular dystrophy (DMD), and one participant with spinal cord injury (SCI). The averaged results, taking into account all participants who were able to control the BCI online, were significantly higher for LSC, 26.11 bit/min and 89.90% accuracy, than for RC, 21.91 bit/min and 88.36% accuracy. The two paradigms produced different waveforms and the signal-to-noise ratio was significantly higher for LSC. Finally, the novel LSC also showed new discriminative features. The results suggest that LSC is an effective alternative to RC, and that LSC still has a margin for potential improvement in bit rate and accuracy. The high bit rates and accuracy of LSC are a step forward for the effective use of BCI in clinical applications. Copyright © 2011 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

45 CFR 1610.2 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... (Organizing activities); (7) Section 1007(b)(8) of the LSC Act (Abortions); (8) Section 1007(b)(9) of the LSC... part 1612 of the LSC Regulations (Public policy training); (9) Section 504(a)(14) (Abortion litigation...

45 CFR 1610.2 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... (Organizing activities); (7) Section 1007(b)(8) of the LSC Act (Abortions); (8) Section 1007(b)(9) of the LSC... part 1612 of the LSC Regulations (Public policy training); (9) Section 504(a)(14) (Abortion litigation...

45 CFR 1610.2 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... (Organizing activities); (7) Section 1007(b)(8) of the LSC Act (Abortions); (8) Section 1007(b)(9) of the LSC... part 1612 of the LSC Regulations (Public policy training); (9) Section 504(a)(14) (Abortion litigation...

45 CFR 1610.2 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... (Organizing activities); (7) Section 1007(b)(8) of the LSC Act (Abortions); (8) Section 1007(b)(9) of the LSC... part 1612 of the LSC Regulations (Public policy training); (9) Section 504(a)(14) (Abortion litigation...

45 CFR 1610.2 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... (Organizing activities); (7) Section 1007(b)(8) of the LSC Act (Abortions); (8) Section 1007(b)(9) of the LSC... part 1612 of the LSC Regulations (Public policy training); (9) Section 504(a)(14) (Abortion litigation...

Scenario-Based Programming, Usability-Oriented Perception

ERIC Educational Resources Information Center

Alexandron, Giora; Armoni, Michal; Gordon, Michal; Harel, David

2014-01-01

In this article, we discuss the possible connection between the programming language and the paradigm behind it, and programmers' tendency to adopt an external or internal perspective of the system they develop. Based on a qualitative analysis, we found that when working with the visual, interobject language of live sequence charts (LSC),…

On the accuracy of the LSC-IVR approach for excitation energy transfer in molecular aggregates

NASA Astrophysics Data System (ADS)

Teh, Hung-Hsuan; Cheng, Yuan-Chung

2017-04-01

We investigate the applicability of the linearized semiclassical initial value representation (LSC-IVR) method to excitation energy transfer (EET) problems in molecular aggregates by simulating the EET dynamics of a dimer model in a wide range of parameter regime and comparing the results to those obtained from a numerically exact method. It is found that the LSC-IVR approach yields accurate population relaxation rates and decoherence rates in a broad parameter regime. However, the classical approximation imposed by the LSC-IVR method does not satisfy the detailed balance condition, generally leading to incorrect equilibrium populations. Based on this observation, we propose a post-processing algorithm to solve the long time equilibrium problem and demonstrate that this long-time correction method successfully removed the deviations from exact results for the LSC-IVR method in all of the regimes studied in this work. Finally, we apply the LSC-IVR method to simulate EET dynamics in the photosynthetic Fenna-Matthews-Olson complex system, demonstrating that the LSC-IVR method with long-time correction provides excellent description of coherent EET dynamics in this typical photosynthetic pigment-protein complex.

Electrochemically influenced cation inter-diffusion and Co 3O 4 formation on La 0.6Sr 0.4CoO 3 infiltrated into SOFC cathodes

DOE PAGES

Song, Xueyan; Lee, Shiwoo; Chen, Yun; ...

2015-06-18

Nanosized LSC electrocatalyst was infiltrated into a porous scaffold cathode composed of Sm 2O 3-doped CeO 2 (SDC) and La 0.6Sr 0.4Co 0.2Fe 0.8O 3-δ (LSCF) in a commercial button solid oxide fuel cell (SOFC). To understand the stability of cathodes infiltrated with LSC, the infiltrated composite cells were subjected to both electrochemical operating and thermal aging states at 750 °C for 1500 h. Nanostructure and local chemistry evolution of La 0.6Sr 0.4CoO 3 (LSC) infiltrated cathodes upon operation and aging were investigated by transmission electron microscopy. After operation, the LSC remained a cubic perovskite, and the crystal grains exhibitmore » comparable size to as-infiltrated LSC grains. Inter-diffusion of Fe from the LSCF to a Fe-incorporated LSC layer developed on the LSCF backbone. However, only sharp interfaces were observed between LSC and SDC backbone in the as-infiltrated cathode and such interfaces remain after operation. The infiltrated LSC on the SDC backbone also retains granular particle morphology. Furthermore, newly grown Co 3O 4 nanocrystals were found in the operated cathode. After thermal aging, on the other hand, cation inter-diffusion across the interfaces of the infiltrate particles and the cathode backbones is less than that from the operated cells. Lastly, the following hypothesis is proposed: Co 3O 4 forms on LSC arising from local charge balancing between cobalt and oxygen vacancies.« less

Modified Oxygen Defect Chemistry at Transition Metal Oxide Heterostructures Probed by Hard X-ray Photoelectron Spectroscopy and X-ray Diffraction

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, Yan; Fong, Dillon D.; Herbert, F. William

Transition metal oxide hetero-structures are interesting due to the distinctly different properties that can arise from their interfaces, such as superconductivity, high catalytic activity and magnetism. Oxygen point defects can play an important role at these interfaces in inducing potentially novel properties. The design of oxide hetero-structures in which the oxygen defects are manipulated to attain specific functionalities requires the ability to resolve the state and concentration of local oxygen defects across buried interfaces. In this work, we utilized a novel combination of hard x-ray photoelectron spectroscopy (HAXPES) and high resolution xray diffraction (HRXRD) to probe the local oxygen defectmore » distribution across the buried interfaces of oxide heterolayers. This approach provides a non-destructive way to qualitatively probe locally the oxygen defects in transition metal oxide hetero-structures. We studied two trilayer structures as model systems - the La 0.8Sr 0.2CoO 3-δ/(La 0.5Sr 0.5) 2CoO 4/La 0.8Sr 0.2CoO 3-δ (LSC 113/LSC 214) and the La 0.8Sr 0.2CoO 3-δ/La 2NiO 4+δ/La 0.8Sr 0.2CoO 3-δ (LSC 113/LNO 214) on SrTiO 3(001) single crystal substrates. We found that the oxygen defect chemistry of these transition metal oxides was strongly impacted by the presence of interfaces and the properties of the adjacent phases. Under reducing conditions, the LSC 113 in the LSC 113/LNO 214 tri-layer had less oxygen vacancies than the LSC 113 in the LSC 113/LSC 214 tri-layer and the LSC 113 single phase film. On the other hand, LSC 214 and LNO 214 were more reduced in the two tri-layer structures when in contact with the LSC 113 layer compared to their single phase counterparts. Furthermore, the results point out a potential way to modify the local oxygen defect states at oxide hetero-interfaces.« less

Modified Oxygen Defect Chemistry at Transition Metal Oxide Heterostructures Probed by Hard X-ray Photoelectron Spectroscopy and X-ray Diffraction

DOE PAGES

Chen, Yan; Fong, Dillon D.; Herbert, F. William; ...

2018-04-17

Transition metal oxide hetero-structures are interesting due to the distinctly different properties that can arise from their interfaces, such as superconductivity, high catalytic activity and magnetism. Oxygen point defects can play an important role at these interfaces in inducing potentially novel properties. The design of oxide hetero-structures in which the oxygen defects are manipulated to attain specific functionalities requires the ability to resolve the state and concentration of local oxygen defects across buried interfaces. In this work, we utilized a novel combination of hard x-ray photoelectron spectroscopy (HAXPES) and high resolution xray diffraction (HRXRD) to probe the local oxygen defectmore » distribution across the buried interfaces of oxide heterolayers. This approach provides a non-destructive way to qualitatively probe locally the oxygen defects in transition metal oxide hetero-structures. We studied two trilayer structures as model systems - the La 0.8Sr 0.2CoO 3-δ/(La 0.5Sr 0.5) 2CoO 4/La 0.8Sr 0.2CoO 3-δ (LSC 113/LSC 214) and the La 0.8Sr 0.2CoO 3-δ/La 2NiO 4+δ/La 0.8Sr 0.2CoO 3-δ (LSC 113/LNO 214) on SrTiO 3(001) single crystal substrates. We found that the oxygen defect chemistry of these transition metal oxides was strongly impacted by the presence of interfaces and the properties of the adjacent phases. Under reducing conditions, the LSC 113 in the LSC 113/LNO 214 tri-layer had less oxygen vacancies than the LSC 113 in the LSC 113/LSC 214 tri-layer and the LSC 113 single phase film. On the other hand, LSC 214 and LNO 214 were more reduced in the two tri-layer structures when in contact with the LSC 113 layer compared to their single phase counterparts. Furthermore, the results point out a potential way to modify the local oxygen defect states at oxide hetero-interfaces.« less

76 FR 3926 - Notice and Request for Comments: LSC Elimination of the Nevada, South Dakota, and Wyoming Migrant...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-21

...-general'' grants based on poverty populations. In some regions, LSC designates migrant service areas for... the total poverty population. For many years LSC has designated migrant service areas in Nevada, South...

Compulsory Project-Level Involvement and the Use of Program-Level Evaluations: Evaluating the Local Systemic Change for Teacher Enhancement Program

ERIC Educational Resources Information Center

Johnson, Kelli; Weiss, Iris R.

2011-01-01

In 1995, the National Science Foundation (NSF) contracted with principal investigator Iris Weiss and an evaluation team at Horizon Research, Inc. (HRI) to conduct a national evaluation of the Local Systemic Change for Teacher Enhancement program (LSC). HRI conducted the core evaluation under a $6.25 million contract with NSF. This program…

77 FR 35718 - LSC Strategic Plan 2012-2016; Request for Comments

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-14

... LEGAL SERVICES CORPORATION LSC Strategic Plan 2012-2016; Request for Comments AGENCY: Legal Services Corporation. ACTION: Request for comments. SUMMARY: The Legal Services Corporation (``LSC'' or..., Chief of Staff and Special Assistant to the President, Legal Services Corporation, 3333 K Street NW...

Musashi2 sustains the mixed-lineage leukemia–driven stem cell regulatory program

PubMed Central

Park, Sun-Mi; Gönen, Mithat; Vu, Ly; Minuesa, Gerard; Tivnan, Patrick; Barlowe, Trevor S.; Taggart, James; Lu, Yuheng; Deering, Raquel P.; Hacohen, Nir; Figueroa, Maria E.; Paietta, Elisabeth; Fernandez, Hugo F.; Tallman, Martin S.; Melnick, Ari; Levine, Ross; Leslie, Christina; Lengner, Christopher J.; Kharas, Michael G.

2015-01-01

Leukemia stem cells (LSCs) are found in most aggressive myeloid diseases and contribute to therapeutic resistance. Leukemia cells exhibit a dysregulated developmental program as the result of genetic and epigenetic alterations. Overexpression of the RNA-binding protein Musashi2 (MSI2) has been previously shown to predict poor survival in leukemia. Here, we demonstrated that conditional deletion of Msi2 in the hematopoietic compartment results in delayed leukemogenesis, reduced disease burden, and a loss of LSC function in a murine leukemia model. Gene expression profiling of these Msi2-deficient animals revealed a loss of the hematopoietic/leukemic stem cell self-renewal program and an increase in the differentiation program. In acute myeloid leukemia patients, the presence of a gene signature that was similar to that observed in Msi2-deficent murine LSCs correlated with improved survival. We determined that MSI2 directly maintains the mixed-lineage leukemia (MLL) self-renewal program by interacting with and retaining efficient translation of Hoxa9, Myc, and Ikzf2 mRNAs. Moreover, depletion of MLL target Ikzf2 in LSCs reduced colony formation, decreased proliferation, and increased apoptosis. Our data provide evidence that MSI2 controls efficient translation of the oncogenic LSC self-renewal program and suggest MSI2 as a potential therapeutic target for myeloid leukemia. PMID:25664853

76 FR 34102 - Request for Comments-LSC Budget Request for FY 2013

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-10

... LEGAL SERVICES CORPORATION Request for Comments--LSC Budget Request for FY 2013 AGENCY: Legal Services Corporation. ACTION: Request for Comments--LSC Budget Request for FY 2013. SUMMARY: The Legal Services Corporation is beginning the process of developing its FY 2013 budget request to Congress and is...

75 FR 54389 - Request for Comments-LSC Budget Request for FY 2012

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-07

... LEGAL SERVICES CORPORATION Request for Comments--LSC Budget Request for FY 2012 AGENCY: Legal Services Corporation. ACTION: Request for Comments--LSC Budget Request for FY 2012. SUMMARY: The Legal Services Corporation is beginning the process of developing its FY 2012 budget request to Congress and is...

77 FR 27801 - Request for Comments-LSC Budget Request for FY 2014

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-11

... LEGAL SERVICES CORPORATION Request for Comments--LSC Budget Request for FY 2014 AGENCY: Legal Services Corporation. ACTION: Request for Comments--LSC Budget Request for FY 2014. SUMMARY: The Legal Services Corporation is beginning the process of developing its FY 2014 budget request to Congress and is...

Effects of low intensity static electromagnetic radiofrequency fields on leiomyosarcoma and smooth muscle cell lines.

PubMed

Karkabounas, Spyridon; Havelas, Konstantinos; Kostoula, Olga K; Vezyraki, Patra; Avdikos, Antonios; Binolis, Jayne; Hatziavazis, George; Metsios, Apostolos; Verginadis, Ioannis; Evangelou, Angelos

2006-01-01

In this study we investigated the effects of low intensity static radiofrequency electromagnetic field (EMF) causing no thermal effects, on leiomyosarcoma cells (LSC), isolated from tumors of fifteen Wistar rats induced via a 3,4-benzopyrene injection. Electromagnetic resonance frequencies measurements and exposure of cells to static EMF were performed by a device called multi channel dynamic exciter 100 V1 (MCDE). The LSC were exposed to electromagnetic resonance radiofrequencies (ERF) between 10 kHz to 120 kHz, for 45 min. During a 24h period, after the exposure of the LSC to ERF, there was no inhibition of cells proliferation. In contrast, at the end of a 48 h incubation period, LSC proliferation dramatically decreased by more than 98% (P<0.001). At that time, the survived LSC were only 2% of the total cell population exposed to ERF, and under the same culture conditions showed significant decrease of proliferation. These cells were exposed once again to ERF for 45 min (totally 4 sessions of exposure, of 45 min duration each) and tested using a flow cytometer. Experiments as above were repeated five times. It was found that 45% of these double exposed to ERF, LSC (EMF cells) were apoptotic and only a small percentage 2%, underwent mitosis. In order to determinate their metastatic potential, these EMF cells were also counted and tested by an aggregometer for their ability to aggregate platelets and found to maintain this ability., since they showed no difference in platelet aggregation ability compared to the LSC not exposed to ERF (control cells). In conclusion, exposure of LSC to specific ERF, decreases their proliferation rate and induces cell apoptosis. Also, the LSC that survived after exposed to ERF, had a lower proliferation rate compared to the LSC controls (P<0.05) but did not loose their potential for metastases (platelet aggregation ability). The non-malignant SMC were not affected by the EMF exposure (P<0.4). The specific ERF generated from the MCDE electronic device, used in this study, is safe for humans and animals, according to the international safety standards.

Quality factor of luminescent solar concentrators and practical concentration limits attainable with semiconductor quantum dots

DOE PAGES

Klimov, Victor I.; Baker, Thomas A.; Lim, Jaehoon; ...

2016-05-09

In this study, luminescent solar concentrators (LSCs) can be utilized as both large-area collectors of solar radiation supplementing traditional photovoltaic cells as well as semitransparent “solar windows” that provide a desired degree of shading and simultaneously serve as power-generation units. An important characteristic of an LSC is a concentration factor (C) that can be thought of as a coefficient of effective enlargement (or contraction) of the area of a solar cell when it is coupled to the LSC. Here we use analytical and numerical Monte Carlo modeling in addition to experimental studies of quantum-dot-based LSCs to analyze the factors thatmore » influence optical concentration in practical devices. Our theoretical model indicates that the maximum value of C achievable with a given fluorophore is directly linked to the LSC quality factor (Q LSC) defined as the ratio of absorption coefficients at the wavelengths of incident and reemitted light. In fact, we demonstrate that the ultimate concentration limit (C 0) realized in large-area devices scales linearly with the LSC quality factor and in the case of perfect emitters and devices without back reflectors is approximately equal to Q LSC. To test the predictions of this model, we conduct experimental studies of LSCs based on visible-light emitting II–VI core/shell quantum dots with two distinct LSC quality factors. We also investigate devices based on near-infrared emitting CuInSe xS 2–x quantum dots for which the large emission bandwidth allows us to assess the impact of varied Q LSC on the concentration factor by simply varying the detection wavelength. In all cases, we find an excellent agreement between the model and the experimental observations, suggesting that the developed formalism can be utilized for express evaluation of prospective LSC performance based on the optical spectra of LSC fluorophores, which should facilitate future efforts on the development of high-performance devices based on quantum dots as well as other types of emitters.« less

Quality factor of luminescent solar concentrators and practical concentration limits attainable with semiconductor quantum dots

DOE Office of Scientific and Technical Information (OSTI.GOV)

Klimov, Victor I.; Baker, Thomas A.; Lim, Jaehoon

In this study, luminescent solar concentrators (LSCs) can be utilized as both large-area collectors of solar radiation supplementing traditional photovoltaic cells as well as semitransparent “solar windows” that provide a desired degree of shading and simultaneously serve as power-generation units. An important characteristic of an LSC is a concentration factor (C) that can be thought of as a coefficient of effective enlargement (or contraction) of the area of a solar cell when it is coupled to the LSC. Here we use analytical and numerical Monte Carlo modeling in addition to experimental studies of quantum-dot-based LSCs to analyze the factors thatmore » influence optical concentration in practical devices. Our theoretical model indicates that the maximum value of C achievable with a given fluorophore is directly linked to the LSC quality factor (Q LSC) defined as the ratio of absorption coefficients at the wavelengths of incident and reemitted light. In fact, we demonstrate that the ultimate concentration limit (C 0) realized in large-area devices scales linearly with the LSC quality factor and in the case of perfect emitters and devices without back reflectors is approximately equal to Q LSC. To test the predictions of this model, we conduct experimental studies of LSCs based on visible-light emitting II–VI core/shell quantum dots with two distinct LSC quality factors. We also investigate devices based on near-infrared emitting CuInSe xS 2–x quantum dots for which the large emission bandwidth allows us to assess the impact of varied Q LSC on the concentration factor by simply varying the detection wavelength. In all cases, we find an excellent agreement between the model and the experimental observations, suggesting that the developed formalism can be utilized for express evaluation of prospective LSC performance based on the optical spectra of LSC fluorophores, which should facilitate future efforts on the development of high-performance devices based on quantum dots as well as other types of emitters.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Douglas, Matthew; Bernacki, Bruce E.; Erchinger, Jennifer L.

Liquid scintillation counting (LSC) is a versatile and commonplace method for radiometric measurement of charged particle emitting radionuclides. The LSC method provides utility in a range of environmental science applications including hydrological studies of water transport, anthropogenic releases of radionuclides into the environment, and vertical mixing rates within oceans. Instrumental measurement background is one limiting factor of radiometric measurement sensitivity. As part of the development of a custom low background LSC system located in a shallow underground laboratory at Pacific Northwest National Laboratory, a number of measurement applications of LSC have been considered and are summarized here. The focus ismore » on determining which aspects of such measurements would gain the greatest benefit from the reduction of LSC backgrounds by a factor of 10-100 relative to values reported in the literature. Examples of benefits include lowering the minimum detectable activity, reducing the sample size required, and shortening the elapsed timeline of the processing and analysis sequence. In particular tritium, strontium, and actinium isotopes are examined as these isotopes cover a range of requirements related to the LSC measurement method (e.g., 3H: low energy; Sr: spectral deconvolution; Ac: alpha/beta discrimination).« less

Cessations and reversals of the large-scale circulation in turbulent thermal convection.

PubMed

Xi, Heng-Dong; Xia, Ke-Qing

2007-06-01

We present an experimental study of cessations and reversals of the large-scale circulation (LSC) in turbulent thermal convection in a cylindrical cell of aspect ratio (Gamma) 1/2 . It is found that cessations and reversals of the LSC occur in Gamma = 1/2 geometry an order-of-magnitude more frequently than they do in Gamma=1 cells, and that after a cessation the LSC is most likely to restart in the opposite direction, i.e., reversals of the LSC are the most probable cessation events. This contrasts sharply to the finding in Gamma=1 geometry and implies that cessations in the two geometries are governed by different dynamics. It is found that the occurrence of reversals is a Poisson process and that a stronger rebound of the flow strength after a reversal or cessation leads to a longer period of stability of the LSC. Several properties of reversals and cessations in this system are found to be statistically similar to those of geomagnetic reversals. A direct measurement of the velocity field reveals that a cessation corresponds to a momentary decoherence of the LSC.

Local Subspace Classifier with Transform-Invariance for Image Classification

NASA Astrophysics Data System (ADS)

Hotta, Seiji

A family of linear subspace classifiers called local subspace classifier (LSC) outperforms the k-nearest neighbor rule (kNN) and conventional subspace classifiers in handwritten digit classification. However, LSC suffers very high sensitivity to image transformations because it uses projection and the Euclidean distances for classification. In this paper, I present a combination of a local subspace classifier (LSC) and a tangent distance (TD) for improving accuracy of handwritten digit recognition. In this classification rule, we can deal with transform-invariance easily because we are able to use tangent vectors for approximation of transformations. However, we cannot use tangent vectors in other type of images such as color images. Hence, kernel LSC (KLSC) is proposed for incorporating transform-invariance into LSC via kernel mapping. The performance of the proposed methods is verified with the experiments on handwritten digit and color image classification.

75 FR 56580 - Sunshine Act Meeting of LSC Board of Directors and Its Finance Committee

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-16

... LEGAL SERVICES CORPORATION Sunshine Act Meeting of LSC Board of Directors and Its Finance Committee TIME AND DATE: The Legal Services Corporation (``LSC'' or ``Corporation'') Board of Directors (``Board'') and its Finance Committee will meet consecutively on September 21, 2010, with the Finance Committee convening at 10 a.m., Eastern Time, and...

Thermal convection of liquid metal in a long inclined cylinder

NASA Astrophysics Data System (ADS)

Teimurazov, Andrei; Frick, Peter

2017-11-01

The turbulent convection of low-Prandtl-number fluids (Pr=0.0083 ) in a long cylindrical cell, heated at one end face and cooled at the other, inclined to the vertical at angle β , 0 ≤β ≤π /2 with step π /20 , is studied numerically by solving the Oberbeck-Boussinesq equations with the large-eddy-simulation approach for small-scale turbulence. The cylinder length is L =5 D , where D is the diameter. The Rayleigh number, determined by the cylinder diameter, is of the order of 5 ×106 . We show that the structure of the flow strongly depends on the inclination angle. A stable large-scale circulation (LSC) slightly disturbed by small-scale turbulence exists in the horizontal cylinder. The deviation from a horizontal position provides strong amplification of both LSC and small-scale turbulence. The energy of turbulent pulsations increases monotonically with decreasing inclination angle β , matching the energy of the LSC at β ≈π /5 . The intensity of the LSC has a wide, almost flat, maximum for an inclined cylinder and slumps approaching the vertical position, in which the LSC vanishes. The dependence of the Nusselt number on the inclination angle has a maximum at β ≈7 π /20 and generally follows the dependence of the intensity of LSC on the inclination. This indicates that the total heat transport is highly determined by LSC. We examine the applicability of idealized thermal boundary conditions (BCs) for modeling a real experiment with liquid sodium flows. Therefore, the simulations are done with two types of temperature BCs: fixed face temperature and fixed heat flux. The intensity of the LSC is slightly higher in the latter case and leads to a corresponding increase of the Nusselt number and enhancement of temperature pulsations.

Work load, job control and risk of leaving work by sickness certification before delivery, Norway 1989.

PubMed

Strand, K; Wergeland, E; Bjerkedal, T

1997-09-01

Sickness absence in pregnancy has been shown to be associated with strenuous working conditions and parity. So far, few studies have made adjustments for possible interaction and confounding. Such adjustments are needed to more precisely identify targets for preventive measures. We have, therefore, in a representative population of pregnant employees in Norway 1989, computed adjusted odds ratios for leaving work by sickness absence more than three (LSC > 3) and eight (LSC > 8) weeks before delivery according to working conditions identified as risk factors in earlier studies; adjusted for job control, domestic conditions and sickness absence the year prior to pregnancy. The cumulative percentage of LSC > 8 and LSC > 3 was 26.4 and 51.1. Ergonomically strenuous postures and heavy lifting increased the risk of both outcomes. In addition, shift work and hectic work pace increased the risk of LSC > 3. Influence on breaks reduced risk. Only para experienced reduced risk of LSC when working part-time. Sicklisting the year prior to pregnancy had no confounding effect, which suggest that pregnancy represents a new incompatibility with work. Preventive measures should address work postures and heavy lifting, as well as conditions influencing the woman's control with her time.

Effect of weak rotation on large-scale circulation cessations in turbulent convection.

PubMed

Assaf, Michael; Angheluta, Luiza; Goldenfeld, Nigel

2012-08-17

We investigate the effect of weak rotation on the large-scale circulation (LSC) of turbulent Rayleigh-Bénard convection, using the theory for cessations in a low-dimensional stochastic model of the flow previously studied. We determine the cessation frequency of the LSC as a function of rotation, and calculate the statistics of the amplitude and azimuthal velocity fluctuations of the LSC as a function of the rotation rate for different Rayleigh numbers. Furthermore, we show that the tails of the reorientation PDF remain unchanged for rotating systems, while the distribution of the LSC amplitude and correspondingly the cessation frequency are strongly affected by rotation. Our results are in close agreement with experimental observations.

Survivin Selectively Modulates Genes Deregulated in Human Leukemia Stem Cells

PubMed Central

Fukuda, Seiji; Abe, Mariko; Onishi, Chie; Taketani, Takeshi; Purevsuren, Jamiyan; Yamaguchi, Seiji; Conway, Edward M.; Pelus, Louis M.

2011-01-01

ITD-Flt3 mutations are detected in leukemia stem cells (LSCs) in acute myeloid leukemia (AML) patients. While antagonizing Survivin normalizes ITD-Flt3-induced acute leukemia, it also impairs hematopoietic stem cell (HSC) function, indicating that identification of differences in signaling pathways downstream of Survivin between LSC and HSC are crucial to develop selective Survivin-based therapeutic strategies for AML. Using a Survivin-deletion model, we identified 1,096 genes regulated by Survivin in ITD-Flt3-transformed c-kit+, Sca-1+, and lineageneg (KSL) cells, of which 137 are deregulated in human LSC. Of the 137, 124 genes were regulated by Survivin exclusively in ITD-Flt3+ KSL cells but not in normal CD34neg KSL cells. Survivin-regulated genes in LSC connect through a network associated with the epidermal growth factor receptor signaling pathway and falls into various functional categories independent of effects on apoptosis. Pathways downstream of Survivin in LSC that are distinct from HSC can be potentially targeted for selective anti-LSC therapy. PMID:21253548

Ecotoxicological assessment of bluegill sunfish inhabiting a selenium-enriched fly ash stream

DOE Office of Scientific and Technical Information (OSTI.GOV)

Reash, R.J.; Lohner, T.W.; Wood, K.V.

1999-07-01

Little Scary Creek (LSC), a 2nd-order tributary of the Kanawha River in West Virginia, receives treated fly ash produced during coal combustion. Selenium and other trace metals were determined in water column and sediment samples, caddisflies, and bluegill sunfish liver and gonads during 1995--96 to estimate pathways of selenium exposure and assess the likelihood of toxic effects. Selenium levels in LSC water and sediment samples, and in caddisflies were elevated compared to reference sites. Mean dry weight selenium concentrations in bluegill liver, ovary, and tested tissue equaled or exceeded published toxic thresholds. Other trace metals were significantly higher in LSCmore » bluegill. Leukopenia, elevated serum salts, and lowered liver weight were found in LSC bluegill. Fewer older bluegill were found in LSC. Sunfish in LSC are experiencing various kinds of sublethal stress, presumably due to metals exposure. However, major toxic effects that would be predicted to occur based on tissue selenium levels (complete reproductive failure or mortality) have not been observed in this population.« less

Laser scanning cytometry (LCS) allows detailed analysis of the cell cycle in PI stained human fibroblasts (TIG-7).

PubMed

Kawasaki, M; Sasaki, K; Satoh, T; Kurose, A; Kamada, T; Furuya, T; Murakami, T; Todoroki, T

1997-01-01

We have demonstrated a method for the in situ determination of the cell cycle phases of TIG-7 fibroblasts using a laser scanning cytometer (LSC) which has not only a function equivalent to flow cytometry (FCM) but also has a capability unique in itself. LSC allows a more detailed analysis of the cell cycle in cells stained with propidium iodide (PI) than FCM. With LSC it is possible to discriminate between mitotic cells and G2 cells, between post-mitotic cells and G1 cells, and between quiescent cells and cycling cells in a PI fluorescence peak (chromatin condensation) vs. fluorescence value (DNA content) cytogram for cells stained with PI. These were amply confirmed by experiments using colcemid and adriamycin. We were able to identify at least six cell subpopulations for PI stained cells using LSC; namely G1, S, G2, M, postmitotic and quiescent cell populations. LSC analysis facilitates the monitoring of effects of drugs on the cell cycle.

Temperature oscillation and the sloshing motion of the large-scale circulation in turbulent Rayleigh-Bénard convection

NASA Astrophysics Data System (ADS)

Xi, Heng-Dong; Chen, Xin; Xia, Ke-Qing

2017-11-01

We report an experimental study of the temperature oscillation and the sloshing motion of the large-scale circulation (LSC) in turbulent Rayleigh-Bénard convection in water. Temperature measurements were made in aspect ratio one cylindrical cell by probes put in fluid and embedded in the sidewall simultaneously, and located at the 1/4, 1/2 and 3/4 heights of the convection cell. The results show that the temperature measured in fluid contains information of both the LSC and the signature of the hot and cold plumes, while the temperature measured in sidewall only contains information of the LSC. It is found that the sloshing motion of the LSC can be measured by both the temperatures in fluid and in sidewall. We also studies the effect of cell tilting on the temperature oscillation and sloshing motion of the LSC. It is found that both the amplitude and the frequency of the temperature oscillation (and the sloshing motion) increase when the tilt angle increases, while the off-center distance of the sloshing motion of the LSC remains unchanged. This work is supported by the NSFC of China (Grant Nos. 11472094 and U1613227), the RGC of Hong Kong SAR (Grant No. 403712) and the 111 project of China (Grant No. B17037).

Spike sorting using locality preserving projection with gap statistics and landmark-based spectral clustering.

PubMed

Nguyen, Thanh; Khosravi, Abbas; Creighton, Douglas; Nahavandi, Saeid

2014-12-30

Understanding neural functions requires knowledge from analysing electrophysiological data. The process of assigning spikes of a multichannel signal into clusters, called spike sorting, is one of the important problems in such analysis. There have been various automated spike sorting techniques with both advantages and disadvantages regarding accuracy and computational costs. Therefore, developing spike sorting methods that are highly accurate and computationally inexpensive is always a challenge in the biomedical engineering practice. An automatic unsupervised spike sorting method is proposed in this paper. The method uses features extracted by the locality preserving projection (LPP) algorithm. These features afterwards serve as inputs for the landmark-based spectral clustering (LSC) method. Gap statistics (GS) is employed to evaluate the number of clusters before the LSC can be performed. The proposed LPP-LSC is highly accurate and computationally inexpensive spike sorting approach. LPP spike features are very discriminative; thereby boost the performance of clustering methods. Furthermore, the LSC method exhibits its efficiency when integrated with the cluster evaluator GS. The proposed method's accuracy is approximately 13% superior to that of the benchmark combination between wavelet transformation and superparamagnetic clustering (WT-SPC). Additionally, LPP-LSC computing time is six times less than that of the WT-SPC. LPP-LSC obviously demonstrates a win-win spike sorting solution meeting both accuracy and computational cost criteria. LPP and LSC are linear algorithms that help reduce computational burden and thus their combination can be applied into real-time spike analysis. Copyright © 2014 Elsevier B.V. All rights reserved.

microRNA-7 down-regulation mediates excessive collagen expression in localized scleroderma.

PubMed

Etoh, Mitsuhiko; Jinnin, Masatoshi; Makino, Katsunari; Yamane, Keitaro; Nakayama, Wakana; Aoi, Jun; Honda, Noritoshi; Kajihara, Ikko; Makino, Takamitsu; Fukushima, Satoshi; Ihn, Hironobu

2013-01-01

Localized scleroderma (LSc), a connective tissue disorder restricted to the skin and subcutaneous tissue, is characterized by skin fibrosis due to an excessive deposition of types I collagen. The mechanism of such fibrosis is still unknown, but epigenetics may play some roles in the excessive collagen expression. In the present study, we investigated the mechanism of fibrosis seen in LSc, focusing on microRNA (miRNA). miRNA expression was determined by PCR array, real-time PCR, and in situ hybridization. The function of miRNA was evaluated using specific inhibitor. Immunoblotting was performed to detect α2(I) collagen protein. PCR array analysis using tissue miRNA demonstrated miR-7 level was significantly decreased in LSc skin as well as keloid tissue compared to normal skin in vivo. In situ hybridization also showed miR-7 expression in dermal fibroblasts was decreased in LSc dermis. The transfection of specific inhibitor for miR-7 into cultured normal dermal fibroblasts resulted in the up-regulation of α2(I) collagen protein in vitro. Also, the serum levels of miR-7 were significantly decreased in LSc patients compared with healthy controls, but serum miR-29a levels not. Systemic or local down-regulation of miR-7 may contribute to the pathogenesis of LSc via the overexpression of α2(I) collagen, and serum miR-7 may be useful as a disease marker. Investigation of the regulatory mechanisms of LSc by miRNA may lead to new treatments by the transfection into the lesional skin of this disease.

Plasma Physics/Fusion Energy Education at the Liberty Science Center

NASA Astrophysics Data System (ADS)

Zwicker, Andrew; Delooper, John; Carpe, Andy; Amara, Joe; Butnick, Nancy; Lynch, Ellen; Osowski, Jeff

2007-11-01

The Liberty Science Center (LSC) is the largest (300,000 sq. ft.) education resource in the New Jersey-New York City region. A major 109 million expansion and renewal was recently completed. Accordingly, PPPL has expanded the science education collaboration with the Center into three innovative, hands-on programs. On the main floor, a new fusion exhibit is one of the focuses of ``Energy Quest.'' This includes a DC glow discharge tube with a permanent external magnet allowing visitors to manipulate the plasma while reading information on plasma creation and fusion energy. In the section of LSC dedicated to intensive science investigations (20,000 sq. ft) we have added ``Live from NSTX'' which will give students an opportunity to connect via video-conferencing to the NSTX control room during plasma operations. A prototype program was completed in May, 2007 with three high school physics classes and will be expanded when NSTX resumes operation. Finally, a plasma physics laboratory in this area will have a fully functioning, research-grade plasma source that will allow long-term visitors an opportunity to perform experiments in plasma processing, plasma spectroscopy, and dusty plasmas.

The rarity of ALDH(+) cells is the key to separation of normal versus leukemia stem cells by ALDH activity in AML patients.

PubMed

Hoang, Van T; Buss, Eike C; Wang, Wenwen; Hoffmann, Isabel; Raffel, Simon; Zepeda-Moreno, Abraham; Baran, Natalia; Wuchter, Patrick; Eckstein, Volker; Trumpp, Andreas; Jauch, Anna; Ho, Anthony D; Lutz, Christoph

2015-08-01

To understand the precise disease driving mechanisms in acute myeloid leukemia (AML), comparison of patient matched hematopoietic stem cells (HSC) and leukemia stem cells (LSC) is essential. In this analysis, we have examined the value of aldehyde dehydrogenase (ALDH) activity in combination with CD34 expression for the separation of HSC from LSC in 104 patients with de novo AML. The majority of AML patients (80 out of 104) had low percentages of cells with high ALDH activity (ALDH(+) cells; <1.9%; ALDH-rare AML), whereas 24 patients had relatively numerous ALDH(+) cells (≥1.9%; ALDH-numerous AML). In patients with ALDH-rare AML, normal HSC could be separated by their CD34(+) ALDH(+) phenotype, whereas LSC were exclusively detected among CD34(+) ALDH(-) cells. For patients with ALDH-numerous AML, the CD34(+) ALDH(+) subset consisted mainly of LSC and separation from HSC was not feasible. Functional analyses further showed that ALDH(+) cells from ALDH-numerous AML were quiescent, refractory to ARA-C treatment and capable of leukemic engraftment in a xenogenic mouse transplantation model. Clinically, resistance to chemotherapy and poor long-term outcome were also characteristic for patients with ALDH-numerous AML providing an additional risk-stratification tool. The difference in spectrum and relevance of ALDH activity in the putative LSC populations demonstrates, in addition to phenotypic and genetic, also functional heterogeneity of leukemic cells and suggests divergent roles for ALDH activity in normal HSC versus LSC. By acknowledging these differences our study provides a new and useful tool for prospective identification of AML cases in which separation of HSC from LSC is possible. © 2014 UICC.

Immunophenotyping by slide-based cytometry and by flow cytometry are comparable

NASA Astrophysics Data System (ADS)

Gerstner, Andreas O.; Laffers, Wiebke; Mittag, Anja; Daehnert, Ingo; Lenz, Domnik; Bootz, Friedrich; Bocsi, Jozsef; Tarnok, Attila

2005-03-01

Immunophenotyping of peripheral blood leukocytes (PBLs) is performed by flow cytometry (FCM) as the golden standard. Slide based cytometry systems for example laser scanning cytometer (LSC) can give additional information (repeated staining and scanning, morphology). In order to adequately judge on the clinical usefulness of immunophenotyping by LSC it is obligatory to compare it with the long established FCM assays. We performed this study to systematically compare the two methods, FCM and LSC for immunophenotyping and to test the correlation of the results. Leucocytes were stained with directly labeled monoclonal antibodies with whole blood staining method. Aliquots of the same paraformaldehyde fixed specimens were analyzed in a FACScan (BD-Biosciences) using standard protocols and parallel with LSC (CompuCyte) after placing to glass slide, drying and fixation by aceton and 7-AAD staining. Calculating the percentage distribution of PBLs obtained by LSC and by FCM shows very good correlation with regression coefficients close to 1.0 for the major populations (neutrophils, lymphocytes, and monocytes), as well as for the lymphocyte sub-populations (T-helper-, T-cytotoxic-, B-, NK-cells). LSC can be recommended for immunophenotyping of PBLs especially in cases where only very limited sample volumes are available or where additional analysis of the cells" morphology is important. There are limitations in the detection of rare leucocytes or weak antigens where appropriate amplification steps for immunofluorescence should be engaged.

Postoperative pain medication requirements in patients undergoing computer-assisted (“Robotic”) and standard laparoscopic procedures for newly diagnosed endometrial cancer.

PubMed

Leitao, Mario M; Malhotra, Vivek; Briscoe, Gabriel; Suidan, Rudy; Dholakiya, Priyal; Santos, Kevin; Jewell, Elizabeth L; Brown, Carol L; Sonoda, Yukio; Abu-Rustum, Nadeem R; Barakat, Richard R; Gardner, Ginger J

2013-10-01

Laparoscopy (LSC) offers superior patient outcomes compared to laparotomy. Small retrospective/prospective series have suggested robotics offers further reduction in postoperative pain and pain medication use compared to standard LSC. Our objective was to compare postoperative pain in patients undergoing robotically assisted (RBT) versus standard LSC for newly diagnosed endometrial cancer. All preoperative endometrial cancer cases scheduled for RBT and LSC from May 1, 2007 to June 9, 2010 were identified. For this analysis, we only included cases not requiring conversion to laparotomy. All patients were offered intravenous (IV) patient-controlled analgesia (PCA) postoperatively. Intraoperative equivalent fentanyl doses (IEFDs) and pain scores in the postanesthesia care unit (PACU) were assessed. IV PCA was used in 206 RBTs (86 %) and 208 LSCs (88 %). Median IEFD was 425 μg for LSCs and 500 μg for RBTs (P = 0.03). Median pain scores on PACU arrival were similar in both groups. Median highest pain score was 5 for LSCs and 4 for RBTs (P = 0.007). Linear regression demonstrated that the IEFD was not correlated with the highest pain score (R = 0.09; P = 0.07). Fentanyl was used postoperatively in 196 of 206 RBTs (95 %) and 187 of 208 LSCs (90 %). The total fentanyl doses were 242.5 (range 0-2705) μg and 380 (range 0-2625) μg, respectively (P < 0.001). The median hourly fentanyl doses were 16.7 (range 0-122.5) μg and 23.5 (range 0-132.4) μg, respectively (P = 0.005). Simultaneous multiple regression analysis further demonstrated RBT was independently associated with a lower total fentanyl dose compared to LSC (P = 0.02). RBT is independently associated with significantly lower postoperative pain and pain medication requirements compared to LSC. The amount of intraoperative fentanyl analgesia does not appear to correlate with postoperative pain.Endometrial cancer is the most common gynecologic malignancy in the United States, with an estimated 47,130 new cases in 2012.1 An estimated 287,100 women were diagnosed with endometrial cancer worldwide in 2008.2 Surgery is the primary treatment of choice for the majority of these women.3 The standard surgical approach has been total abdominal hysterectomy, bilateral salpingo-oophorectomy, and staging via laparotomy. Multiple retrospective series have shown that a less invasive surgical approach via laparoscopy (LSC) is feasible and safe, and also associated with improved perioperative outcomes compared to laparotomy in these patients.4 The Gynecologic Oncology Group (GOG) published results of the largest randomized trial (LAP2) comparing LSC to laparotomy in patients with newly diagnosed endometrial carcinoma in 2009.5,6 This landmark study essentially changed the accepted standard surgical approach in this group. Postoperative complications, median blood loss, and median length of stay (LOS), despite increased operative time, were significantly lower in LSC patients despite 25 % requiring conversion to laparotomy.5 The first 802 eligible patients randomized in LAP2 also participated in a quality-of-life (QOL) study. Within 6 weeks of surgery, patients assigned to LSC reported significantly better QOL on all scales other than fear of recurrence.6 Overall, during this 6-week postoperative period, patients assigned to LSC had superior QOL, fewer physical symptoms, less pain and pain-related interference with functioning, better physical functioning and emotional state, earlier resumption of normal activities, earlier return to work, and better body image compared to those assigned to laparotomy.6 Recurrence-free and overall survivals were the same in both groups.7 Multiple published retrospective series have shown possible benefits, such as reduced postoperative pain, using the robotic (RBT) platform compared to LSC or laparotomy in patients with endometrial cancer.8-11 In a randomized trial, LSC was found to be associated with less postoperative pain compared to vaginal approaches in patients undergoing hysterectomy for benign gynecologic disease.12 A small retrospective series reported further reductions in postoperative pain in patients who had undergone an RBT hysterectomy compared to a standard total LSC hysterectomy for benign indications.13 A recent cost analysis suggested that patients experienced less pain and required less pain medication use after RBT procedures compared to LSC for endometrial cancer.14 Based on these reports, we sought to analyze postoperative pain and the use of pain medication in patients undergoing RBT compared to standard transperitoneal LSC procedures for newly diagnosed endometrial cancer during a concurrent time period. Of note, current RBT surgery is not truly robotic in that it is not autonomous. A more appropriate term is “computer-assisted surgery,” but to satisfy current convention, we refer to it as “robotic surgery” in this manuscript.

A randomized controlled trial of soap opera videos streamed to smartphones to reduce risk of sexually transmitted human immunodeficiency virus (HIV) in young urban African American women.

PubMed

Jones, Rachel; Hoover, Donald R; Lacroix, Lorraine J

2013-01-01

Love, Sex, and Choices (LSC) is a soap opera video series created to reduce HIV sex risk in women. LSC was compared to text messages in a randomized trial in 238 high-risk mostly Black young urban women. 117 received 12-weekly LSC videos, 121 received 12-weekly HIV prevention messages on smartphones. Changes in unprotected sex with high risk partners were compared by mixed models. Unprotected sex with high risk men significantly declined over 6 months post-intervention for both arms, from 21-22 acts to 5-6 (p < 0.001). This reduction was 18 % greater in the video over the text arm, though this difference was not statistically significant. However, the LSC was highly popular and viewers wanted the series to continue. This is the first study to report streaming soap opera video episodes to reduce HIV risk on smartphones. LSC holds promise as an Internet intervention that could be scaled-up and combined with HIV testing. Copyright © 2013 Elsevier Inc. All rights reserved.

Investigation of beamed-energy ERH thruster performance

NASA Technical Reports Server (NTRS)

Myrabo, Leik N.; Strayer, T. Darton; Bossard, John A.; Richard, Jacques C.; Gallimore, Alec D.

1986-01-01

The objective of this study was to determine the performance of an External Radiation Heated (ERH) thruster. In this thruster, high intensity laser energy is focused to ignite either a Laser Supported Combustion (LSC) wave or a Laser Supported Detonation (LSD) wave. Thrust is generated as the LSC or LSD wave propagates over the thruster's surface, or in the proposed thruster configuration, the vehicle afterbody. Thrust models for the LSC and LSD waves were developed and simulated on a computer. Performance parameters investigated include the effect of laser intensity, flight Mach number, and altitude on mean-thrust and coupling coefficient of the ERH thruster. Results from these models suggest that the ERH thruster using LSC/LSD wave ignition could provide propulsion performance considerably greater than any propulsion system currently available.

MicroRNAs in Control of Stem Cells in Normal and Malignant Hematopoiesis

PubMed Central

Roden, Christine; Lu, Jun

2016-01-01

Studies on hematopoietic stem cells (HSCs) and leukemia stem cells (LSCs) have helped to establish the paradigms of normal and cancer stem cell concepts. For both HSCs and LSCs, specific gene expression programs endowed by their epigenome functionally distinguish them from their differentiated progenies. MicroRNAs (miRNAs), as a class of small non-coding RNAs, act to control post-transcriptional gene expression. Research in the past decade has yielded exciting findings elucidating the roles of miRNAs in control of multiple facets of HSC and LSC biology. Here we review recent progresses on the functions of miRNAs in HSC emergence during development, HSC switch from a fetal/neonatal program to an adult program, HSC self-renewal and quiescence, HSC aging, HSC niche, and malignant stem cells. While multiple different miRNAs regulate a diverse array of targets, two common themes emerge in HSC and LSC biology: miRNA mediated regulation of epigenetic machinery and cell signaling pathways. In addition, we propose that miRNAs themselves behave like epigenetic regulators, as they possess key biochemical and biological properties that can provide both stability and alterability to the epigenetic program. Overall, the studies of miRNAs in stem cells in the hematologic contexts not only provide key understandings to post-transcriptional gene regulation mechanisms in HSCs and LSCs, but also will lend key insights for other stem cell fields. PMID:27547713

A simple high performance liquid chromatography method for analyzing paraquat in soil solution samples.

PubMed

Ouyang, Ying; Mansell, Robert S; Nkedi-Kizza, Peter

2004-01-01

A high performance liquid chromatography (HPLC) method with UV detection was developed to analyze paraquat (1,1'-dimethyl-4,4'-dipyridinium dichloride) herbicide content in soil solution samples. The analytical method was compared with the liquid scintillation counting (LSC) method using 14C-paraquat. Agreement obtained between the two methods was reasonable. However, the detection limit for paraquat analysis was 0.5 mg L(-1) by the HPLC method and 0.05 mg L(-1) by the LSC method. The LSC method was, therefore, 10 times more precise than the HPLC method for solution concentrations less than 1 mg L(-1). In spite of the high detection limit, the UC (nonradioactive) HPLC method provides an inexpensive and environmentally safe means for determining paraquat concentration in soil solution compared with the 14C-LSC method.

Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity.

PubMed

Hope, Kristin J; Jin, Liqing; Dick, John E

2004-07-01

Emerging evidence suggests cancer stem cells sustain neoplasms; however, little is understood of the normal cell initially targeted and the resultant cancer stem cells. We show here, by tracking individual human leukemia stem cells (LSCs) in nonobese diabetic-severe combined immunodeficiency mice serially transplanted with acute myeloid leukemia cells, that LSCs are not functionally homogeneous but, like the normal hematopoietic stem cell (HSC) compartment, comprise distinct hierarchically arranged LSC classes. Distinct LSC fates derived from heterogeneous self-renewal potential. Some LSCs emerged only in recipients of serial transplantation, indicating they divided rarely and underwent self-renewal rather than commitment after cell division within primary recipients. Heterogeneity in LSC self-renewal potential supports the hypothesis that they derive from normal HSCs. Furthermore, normal developmental processes are not completely abolished during leukemogenesis. The existence of multiple stem cell classes shows the need for LSC-targeted therapies.

The Impact of a Strategy-Based Intervention on the Comprehension and Strategy Use of Struggling Adolescent Readers

ERIC Educational Resources Information Center

Cantrell, Susan Chambers; Almasi, Janice F.; Carter, Janis C.; Rintamaa, Margaret; Madden, Angela

2010-01-01

This study examines the impact of the Learning Strategies Curriculum (LSC), an adolescent reading intervention program, on 6th- and 9th-grade students' reading comprehension and strategy use. Using a randomized treatment-control group design, the study compared student outcomes for these constructs for 365 students who received daily instruction…

Evolution of acute myelogenous leukemia stem cell properties after treatment and progression.

PubMed

Ho, Tzu-Chieh; LaMere, Mark; Stevens, Brett M; Ashton, John M; Myers, Jason R; O'Dwyer, Kristen M; Liesveld, Jane L; Mendler, Jason H; Guzman, Monica; Morrissette, Jennifer D; Zhao, Jianhua; Wang, Eunice S; Wetzler, Meir; Jordan, Craig T; Becker, Michael W

2016-09-29

Most cancers evolve over time as patients initially responsive to therapy acquire resistance to the same drugs at relapse. Cancer stem cells have been postulated to represent a therapy-refractory reservoir for relapse, but formal proof of this model is lacking. We prospectively characterized leukemia stem cell populations (LSCs) from a well-defined cohort of patients with acute myelogenous leukemia (AML) at diagnosis and relapse to assess the effect of the disease course on these critical populations. Leukemic samples were collected from patients with newly diagnosed AML before therapy and after relapse, and LSC frequency was assessed by limiting dilution analyses. LSC populations were identified using fluorescent-labeled cell sorting and transplantation into immunodeficient NOD/SCID/interleukin 2 receptor γ chain null mice. The surface antigen expression profiles of pretherapy and postrelapse LSCs were determined for published LSC markers. We demonstrate a 9- to 90-fold increase in LSC frequency between diagnosis and relapse. LSC activity at relapse was identified in populations of leukemic blasts that did not demonstrate this activity before treatment and relapse. In addition, we describe genetic instability and exceptional phenotypic changes that accompany the evolution of these new LSC populations. This study is the first to characterize the evolution of LSCs in vivo after chemotherapy, identifying a dramatic change in the physiology of primitive AML cells when the disease progresses. Taken together, these findings provide a new frame of reference by which to evaluate candidate AML therapies in which both disease control and the induction of more advanced forms of disease should be considered. © 2016 by The American Society of Hematology.

Evolution of acute myelogenous leukemia stem cell properties after treatment and progression

PubMed Central

Ho, Tzu-Chieh; LaMere, Mark; Stevens, Brett M.; Ashton, John M.; Myers, Jason R.; O’Dwyer, Kristen M.; Liesveld, Jane L.; Mendler, Jason H.; Guzman, Monica; Morrissette, Jennifer D.; Zhao, Jianhua; Wang, Eunice S.; Wetzler, Meir; Jordan, Craig T.

2016-01-01

Most cancers evolve over time as patients initially responsive to therapy acquire resistance to the same drugs at relapse. Cancer stem cells have been postulated to represent a therapy-refractory reservoir for relapse, but formal proof of this model is lacking. We prospectively characterized leukemia stem cell populations (LSCs) from a well-defined cohort of patients with acute myelogenous leukemia (AML) at diagnosis and relapse to assess the effect of the disease course on these critical populations. Leukemic samples were collected from patients with newly diagnosed AML before therapy and after relapse, and LSC frequency was assessed by limiting dilution analyses. LSC populations were identified using fluorescent-labeled cell sorting and transplantation into immunodeficient NOD/SCID/interleukin 2 receptor γ chain null mice. The surface antigen expression profiles of pretherapy and postrelapse LSCs were determined for published LSC markers. We demonstrate a 9- to 90-fold increase in LSC frequency between diagnosis and relapse. LSC activity at relapse was identified in populations of leukemic blasts that did not demonstrate this activity before treatment and relapse. In addition, we describe genetic instability and exceptional phenotypic changes that accompany the evolution of these new LSC populations. This study is the first to characterize the evolution of LSCs in vivo after chemotherapy, identifying a dramatic change in the physiology of primitive AML cells when the disease progresses. Taken together, these findings provide a new frame of reference by which to evaluate candidate AML therapies in which both disease control and the induction of more advanced forms of disease should be considered. PMID:27421961

78 FR 32474 - Request for Comments: LSC Appropriations Request for FY 2015

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-30

... and is seeking public comment and testimony on what the amount of its request should be. DATES... p.m., Eastern Daylight Time, on Thursday June 6, 2013. LSC invites public comment on what its FY...

Antibody therapy for acute myeloid leukaemia.

PubMed

Gasiorowski, Robin E; Clark, Georgina J; Bradstock, Kenneth; Hart, Derek N J

2014-02-01

Novel therapies with increased efficacy and decreased toxicity are desperately needed for the treatment of acute myeloid leukaemia (AML). The anti CD33 immunoconjugate, gemtuzumab ozogamicin (GO), was withdrawn with concerns over induction mortality and lack of efficacy. However a number of recent trials suggest that, particularly in AML with favourable cytogenetics, GO may improve overall survival. This data and the development of alternative novel monoclonal antibodies (mAb) have renewed interest in the area. Leukaemic stem cells (LSC) are identified as the subset of AML blasts that reproduces the leukaemic phenotype upon transplantation into immunosuppressed mice. AML relapse may be caused by chemoresistant LSC and this has refocused interest on identifying and targeting antigens specific for LSC. Several mAb have been developed that target LSC effectively in xenogeneic models but only a few have begun clinical evaluation. Antibody engineering may improve the activity of potential new therapeutics for AML. The encouraging results seen with bispecific T cell-engaging mAb-based molecules against CD19 in the treatment of B-cell acute lymphobalstic leukaemia, highlight the potential efficacy of engineered antibodies in the treatment of acute leukaemia. Potent engineered mAb, possibly targeting novel LSC antigens, offer hope for improving the current poor prognosis for AML. © 2013 John Wiley & Sons Ltd.

Zero point energy leakage in condensed phase dynamics: An assessment of quantum simulation methods for liquid water

NASA Astrophysics Data System (ADS)

Habershon, Scott; Manolopoulos, David E.

2009-12-01

The approximate quantum mechanical ring polymer molecular dynamics (RPMD) and linearized semiclassical initial value representation (LSC-IVR) methods are compared and contrasted in a study of the dynamics of the flexible q-TIP4P/F water model at room temperature. For this water model, a RPMD simulation gives a diffusion coefficient that is only a few percent larger than the classical diffusion coefficient, whereas a LSC-IVR simulation gives a diffusion coefficient that is three times larger. We attribute this discrepancy to the unphysical leakage of initially quantized zero point energy (ZPE) from the intramolecular to the intermolecular modes of the liquid as the LSC-IVR simulation progresses. In spite of this problem, which is avoided by construction in RPMD, the LSC-IVR may still provide a useful approximation to certain short-time dynamical properties which are not so strongly affected by the ZPE leakage. We illustrate this with an application to the liquid water dipole absorption spectrum, for which the RPMD approximation breaks down at frequencies in the O-H stretching region owing to contamination from the internal modes of the ring polymer. The LSC-IVR does not suffer from this difficulty and it appears to provide quite a promising way to calculate condensed phase vibrational spectra.

Zero point energy leakage in condensed phase dynamics: an assessment of quantum simulation methods for liquid water.

PubMed

Habershon, Scott; Manolopoulos, David E

2009-12-28

The approximate quantum mechanical ring polymer molecular dynamics (RPMD) and linearized semiclassical initial value representation (LSC-IVR) methods are compared and contrasted in a study of the dynamics of the flexible q-TIP4P/F water model at room temperature. For this water model, a RPMD simulation gives a diffusion coefficient that is only a few percent larger than the classical diffusion coefficient, whereas a LSC-IVR simulation gives a diffusion coefficient that is three times larger. We attribute this discrepancy to the unphysical leakage of initially quantized zero point energy (ZPE) from the intramolecular to the intermolecular modes of the liquid as the LSC-IVR simulation progresses. In spite of this problem, which is avoided by construction in RPMD, the LSC-IVR may still provide a useful approximation to certain short-time dynamical properties which are not so strongly affected by the ZPE leakage. We illustrate this with an application to the liquid water dipole absorption spectrum, for which the RPMD approximation breaks down at frequencies in the O-H stretching region owing to contamination from the internal modes of the ring polymer. The LSC-IVR does not suffer from this difficulty and it appears to provide quite a promising way to calculate condensed phase vibrational spectra.

Linearized semiclassical initial value time correlation functions with maximum entropy analytic continuation.

PubMed

Liu, Jian; Miller, William H

2008-09-28

The maximum entropy analytic continuation (MEAC) method is used to extend the range of accuracy of the linearized semiclassical initial value representation (LSC-IVR)/classical Wigner approximation for real time correlation functions. LSC-IVR provides a very effective "prior" for the MEAC procedure since it is very good for short times, exact for all time and temperature for harmonic potentials (even for correlation functions of nonlinear operators), and becomes exact in the classical high temperature limit. This combined MEAC+LSC/IVR approach is applied here to two highly nonlinear dynamical systems, a pure quartic potential in one dimensional and liquid para-hydrogen at two thermal state points (25 and 14 K under nearly zero external pressure). The former example shows the MEAC procedure to be a very significant enhancement of the LSC-IVR for correlation functions of both linear and nonlinear operators, and especially at low temperature where semiclassical approximations are least accurate. For liquid para-hydrogen, the LSC-IVR is seen already to be excellent at T=25 K, but the MEAC procedure produces a significant correction at the lower temperature (T=14 K). Comparisons are also made as to how the MEAC procedure is able to provide corrections for other trajectory-based dynamical approximations when used as priors.

Bigger testes increase paternity in a simultaneous hermaphrodite, independently of the sperm competition level.

PubMed

Vellnow, N; Marie-Orleach, L; Zadesenets, K S; Schärer, L

2018-02-01

Hermaphroditic animals face the fundamental evolutionary optimization problem of allocating their resources to their male vs. female reproductive function (e.g. testes and sperm vs. ovaries and eggs), and this optimal sex allocation can be affected by both pre- and post-copulatory sexual selection. For example, local sperm competition (LSC) - the competition between related sperm for the fertilization of a partner's ova - occurs in small mating groups and can favour a female-biased sex allocation, because, under LSC, investment into sperm production is predicted to show diminishing fitness returns. Here, we test whether higher testis investment increases an individual's paternity success under sperm competition, and whether the strength of this effect diminishes when LSC is stronger, as predicted by sex allocation theory. We created two subsets of individuals of the simultaneously hermaphroditic flatworm Macrostomum lignano - by sampling worms from either the highest or lowest quartile of the testis investment distribution - and estimated their paternity success in group sizes of either three (strong LSC) or eight individuals (weak LSC). Specifically, using transgenic focal individuals expressing a dominant green-fluorescent protein marker, we showed that worms with high testis investment sired 22% more offspring relative to those with low investment, corroborating previous findings in M. lignano and other species. However, the strength of this effect was not significantly modulated by the experienced group size, contrasting theoretical expectations of more strongly diminishing fitness returns under strong LSC. We discuss the possible implications for the evolutionary maintenance of hermaphroditism in M. lignano. © 2017 European Society For Evolutionary Biology. Journal of Evolutionary Biology © 2017 European Society For Evolutionary Biology.

An important role for adenine, cholera toxin, hydrocortisone and triiodothyronine in the proliferation, self-renewal and differentiation of limbal stem cells in vitro.

PubMed

Yu, Min; Bojic, Sanja; Figueiredo, Gustavo S; Rooney, Paul; de Havilland, Julian; Dickinson, Anne; Figueiredo, Francisco C; Lako, Majlinda

2016-11-01

The cornea is a self-renewing tissue located at the front of the eye. Its transparency is essential for allowing light to focus onto the retina for visual perception. The continuous renewal of corneal epithelium is supported by limbal stem cells (LSCs) which are located in the border region between conjunctiva and cornea known as the limbus. Ex vivo expansion of LSCs has been successfully applied in the last two decades to treat patients with limbal stem cell deficiency (LSCD). Various methods have been used for their expansion, yet the most widely used culture media contains a number of ingredients derived from animal sources which may compromise the safety profile of human LSC transplantation. In this study we sought to understand the role of these components namely adenine, cholera toxin, hydrocortisone and triiodothyronine with the aim of re-defining a safe and GMP compatible minimal media for the ex vivo expansion of LSCs on human amniotic membrane. Our data suggest that all four components play a critical role in maintaining LSC proliferation and promoting LSC self-renewal. However removal of adenine and triiodothyronine had a more profound impact and led to LSC differentiation and loss of viability respectively, suggesting their essential role for ex vivo expansion of LSCs. Replacement of each of the components with GMP-grade reagents resulted in equal growth to non-GMP grade media, however an enhanced differentiation of LSCs was observed, suggesting that additional combinations of GMP grade reagents need to be tested to achieve similar or better level of LSC maintenance in the same manner as the traditional LSC media. Crown Copyright © 2016. Published by Elsevier Ltd. All rights reserved.

Biomolecular characterization of the levansucrase of Erwinia amylovora, a promising biocatalyst for the synthesis of fructooligosaccharides.

PubMed

Caputi, Lorenzo; Nepogodiev, Sergey A; Malnoy, Mickael; Rejzek, Martin; Field, Robert A; Benini, Stefano

2013-12-18

Erwinia amylovora is a plant pathogen that affects Rosaceae, such as apple and pear. In E. amylovora the fructans, produced by the action of a levansucrase (EaLsc), play a role in virulence and biofilm formation. Fructans are bioactive compounds, displaying health-promoting properties in their own right. Their use as food and feed supplements is increasing. In this study, we investigated the biomolecular properties of EaLsc using HPAEC-PAD, MALDI-TOF MS, and spectrophotometric assays. The enzyme, which was heterologously expressed in Escherichia coli in high yield, was shown to produce mainly fructooligosaccharides (FOSs) with a degree of polymerization between 3 and 6. The kinetic properties of EaLsc were similar to those of other phylogenetically related Gram-negative bacteria, but the good yield of FOSs, the product spectrum, and the straightforward production of the enzyme suggest that EaLsc is an interesting biocatalyst for future studies aimed at producing tailor-made fructans.

Simultaneous estimation of cross-validation errors in least squares collocation applied for statistical testing and evaluation of the noise variance components

NASA Astrophysics Data System (ADS)

Behnabian, Behzad; Mashhadi Hossainali, Masoud; Malekzadeh, Ahad

2018-02-01

The cross-validation technique is a popular method to assess and improve the quality of prediction by least squares collocation (LSC). We present a formula for direct estimation of the vector of cross-validation errors (CVEs) in LSC which is much faster than element-wise CVE computation. We show that a quadratic form of CVEs follows Chi-squared distribution. Furthermore, a posteriori noise variance factor is derived by the quadratic form of CVEs. In order to detect blunders in the observations, estimated standardized CVE is proposed as the test statistic which can be applied when noise variances are known or unknown. We use LSC together with the methods proposed in this research for interpolation of crustal subsidence in the northern coast of the Gulf of Mexico. The results show that after detection and removing outliers, the root mean square (RMS) of CVEs and estimated noise standard deviation are reduced about 51 and 59%, respectively. In addition, RMS of LSC prediction error at data points and RMS of estimated noise of observations are decreased by 39 and 67%, respectively. However, RMS of LSC prediction error on a regular grid of interpolation points covering the area is only reduced about 4% which is a consequence of sparse distribution of data points for this case study. The influence of gross errors on LSC prediction results is also investigated by lower cutoff CVEs. It is indicated that after elimination of outliers, RMS of this type of errors is also reduced by 19.5% for a 5 km radius of vicinity. We propose a method using standardized CVEs for classification of dataset into three groups with presumed different noise variances. The noise variance components for each of the groups are estimated using restricted maximum-likelihood method via Fisher scoring technique. Finally, LSC assessment measures were computed for the estimated heterogeneous noise variance model and compared with those of the homogeneous model. The advantage of the proposed method is the reduction in estimated noise levels for those groups with the fewer number of noisy data points.

Improved repeatability of nasal potential difference with a larger surface catheter.

PubMed

Vermeulen, François; Proesmans, Marijke; Boon, Mieke; De Boeck, Kris

2015-05-01

To increase the power of nasal potential difference (NPD) as a biomarker of CFTR function, improvement of its repeatability is needed. We evaluated the improvement in repeatability resulting from measuring NPD (1) over a larger surface area and (2) at a fixed location. To assess repeatability, NPD was measured on two occasions with a new method using a larger surface catheter at fixed locations on the nasal floor (LSC-floor(5cm) and LSC-floor(3cm)) or at the most negative basal potential (LSC-floor(max)); with a sidehole catheter on the nasal floor at 5 cm) from the nasal margin (SHC-floor(5cm)) or at the most negative potential (SHC-floor(max)); and with an endhole catheter below the inferior surface of the lower turbinate at the most negative potential (EHC-turb(max)). The within-subject standard deviation (S(w)) for repeated measurements of the total chloride response in the controls was smallest with the LSC-floor at a fixed location (LSC-floor(5cm) 3.1 mV; 95% CI 2.3-4.6 mV) and highest with the SHC-floor (SHC-floor(max) 14.6 mV; 95% CI 10.9-22.2 mV) or the EHC-turbinate (EHC-turb(max) 12.5 mV; 95% CI 10.7-23.0 mV) at the most negative basal potential. Measuring with the LSC-floor at the maximal potential increased the Sw (LSC-floor(max) 8.8 mV, 95% CI 6.0-16.1 mV, p=0.009 vs LSC-floor(5cm)), while measuring with the SHC-floor at a fixed location slightly decreased the Sw (SHC-floor(5cm) 9.8 mV, 95% CI 8.9-20.6 mV, p=0.06 vs SHC-floor(max)). In patients with cystic fibrosis, the S(w) was comparable, between 2.2 mV and 4.3 mV. Sample size calculations for trials using NPD to assess changes in ion transport showed that the number of subjects to be included could be approximately halved measuring with the larger surface catheter at a fixed location vs SHC or EHC at fixed locations. Measuring the NPD at a fixed location and over a larger surface resulted in increased repeatability and thereby also power as a biomarker of CFTR modulation. Copyright © 2014 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.

Modelling and analysis of workflow for lean supply chains

NASA Astrophysics Data System (ADS)

Ma, Jinping; Wang, Kanliang; Xu, Lida

2011-11-01

Cross-organisational workflow systems are a component of enterprise information systems which support collaborative business process among organisations in supply chain. Currently, the majority of workflow systems is developed in perspectives of information modelling without considering actual requirements of supply chain management. In this article, we focus on the modelling and analysis of the cross-organisational workflow systems in the context of lean supply chain (LSC) using Petri nets. First, the article describes the assumed conditions of cross-organisation workflow net according to the idea of LSC and then discusses the standardisation of collaborating business process between organisations in the context of LSC. Second, the concept of labelled time Petri nets (LTPNs) is defined through combining labelled Petri nets with time Petri nets, and the concept of labelled time workflow nets (LTWNs) is also defined based on LTPNs. Cross-organisational labelled time workflow nets (CLTWNs) is then defined based on LTWNs. Third, the article proposes the notion of OR-silent CLTWNS and a verifying approach to the soundness of LTWNs and CLTWNs. Finally, this article illustrates how to use the proposed method by a simple example. The purpose of this research is to establish a formal method of modelling and analysis of workflow systems for LSC. This study initiates a new perspective of research on cross-organisational workflow management and promotes operation management of LSC in real world settings.

Tracing groundwater with low-level detections of halogenated VOCs in a fractured carbonate-rock aquifer, Leetown Science Center, West Virginia, USA

USGS Publications Warehouse

Plummer, Niel; Sibrell, Philip L.; Casile, Gerolamo C.; Busenberg, Eurybiades; Hunt, Andrew G.; Schlosser, Peter

2013-01-01

Measurements of low-level concentrations of halogenated volatile organic compounds (VOCs) and estimates of groundwater age interpreted from 3H/3He and SF6 data have led to an improved understanding of groundwater flow, water sources, and transit times in a karstic, fractured, carbonate-rock aquifer at the Leetown Science Center (LSC), West Virginia. The sum of the concentrations of a set of 16 predominant halogenated VOCs (TDVOC) determined by gas chromatography with electron-capture detector (GC–ECD) exceeded that possible for air–water equilibrium in 34 of the 47 samples (median TDVOC of 24,800 pg kg−1), indicating that nearly all the water sampled in the vicinity of the LSC has been affected by addition of halogenated VOCs from non-atmospheric source(s). Leakage from a landfill that was closed and sealed nearly 20 a prior to sampling was recognized and traced to areas east of the LSC using low-level detection of tetrachloroethene (PCE), methyl chloride (MeCl), methyl chloroform (MC), dichlorodifluoromethane (CFC-12), and cis-1,2-dichloroethene (cis-1,2-DCE). Chloroform (CHLF) was the predominant VOC in water from domestic wells surrounding the LSC, and was elevated in groundwater in and near the Fish Health Laboratory at the LSC, where a leak of chlorinated water occurred prior to 2006. The low-level concentrations of halogenated VOCs did not exceed human or aquatic-life health criteria, and were useful in providing an awareness of the intrinsic susceptibility of the fractured karstic groundwater system at the LSC to non-atmospheric anthropogenic inputs. The 3H/3He groundwater ages of spring discharge from the carbonate rocks showed transient behavior, with ages averaging about 2 a in 2004 following a wet climatic period (2003–2004), and ages in the range of 4–7 a in periods of more average precipitation (2008–2009). The SF6 and CFC-12 data indicate older water (model ages of 10s of years or more) in the low-permeability shale of the Martinsburg Formation located to the west of the LSC. A two-a record of specific conductance, water temperature, and discharge recorded at 30-min intervals demonstrated an approximately 3-month lag in discharge at Gray Spring. The low groundwater ages of waters from the carbonate rocks support rapid advective transport of contaminants from the LSC vicinity, yet the nearly ubiquitous occurrence of low-level concentrations of halogenated VOCs at the LSC suggests the presence of long-term persistent sources, such as seepage from the closed and sealed landfill, infiltration of VOCs that may persist locally in the epikarst, exchange with low-permeability zones in fractured rock, and upward leakage of older water that may contain elevated concentrations of halogenated VOCs from earlier land use activities.

78 FR 51696 - Restrictions on Legal Assistance to Aliens

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-21

... assistance to aliens. The revisions are intended to implement three statutory changes on aliens eligible for... existing regulation were last revised in 1997. Those three changes are described in more detail in the Supplementary Information section of this preamble. LSC seeks comments on the proposed changes to the rule. LSC...

76 FR 56482 - Notice and Request For Comments: LSC Elimination of the West Virginia Migrant Service Area...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-13

... LEGAL SERVICES CORPORATION Notice and Request For Comments: LSC Elimination of the West Virginia Migrant Service Area Beginning January 1, 2012 AGENCY: Legal Services Corporation. ACTION: Notice and Request for Comments. SUMMARY: The Legal Services Corporation will eliminate the West Virginia migrant...

Fire Protection in Educational Occupancies.

ERIC Educational Resources Information Center

Gervais, Romeo P.

2000-01-01

Discusses the origins of school fires and the components of the fire protection code called the Life Safety Code (LSC). Three of the following LSC requirements are described: means of egress; protection from hazards; and fire suppression and alarm systems. Information on who starts fires is highlighted along with preventive measures. (GR)

76 FR 55710 - Sunshine Act Meeting of LSC Board of Directors Finance Committee

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-08

... LEGAL SERVICES CORPORATION Sunshine Act Meeting of LSC Board of Directors Finance Committee TIME...'') Finance Committee will meet telephonically on September 13, 2011 at 11 a.m., Eastern Time. LOCATION: Legal..., please ``mute'' your telephone immediately. MATTERS TO BE CONSIDERED: Finance Committee Agenda Open...

76 FR 4378 - Sunshine Act Meetings; Notice

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-25

... Directors and non- voting Non-Directors to committees. 9. Consider and act on Resolution 2011-XXX thanking... participation on the 2010 Search Committee for LSC President. 12. Consider and act on Resolution 2011-XXX dissolving the 2010 Search Committee for LSC President. 13. Consider and act on Resolution 2011-XXX...

Standardization of Tc-99 by two methods and participation at the CCRI(II)-K2. Tc-99 comparison.

PubMed

Sahagia, M; Antohe, A; Ioan, R; Luca, A; Ivan, C

2014-05-01

The work accomplished within the participation at the 2012 key comparison of Tc-99 is presented. The solution was standardized for the first time in IFIN-HH by two methods: LSC-TDCR and 4π(PC)β-γ efficiency tracer. The methods are described and the results are compared. For the LSC-TDCR method, the program TDCR07c, written and provided by P. Cassette, was used for processing the measurement data. The results are 2.1% higher than when applying the TDCR06b program; the higher value, calculated with the software TDCR07c, was used for reporting the final result in the comparison. The tracer used for the 4π(PC)β-γ efficiency tracer method was a standard (60)Co solution. The sources were prepared from the mixture (60)Co+(99)Tc solution and a general extrapolation curve, type: N(βTc-99)/(M)(Tc-99)=f [1-ε(Co-60)], was drawn. This value was not used for the final result of the comparison. The difference between the values of activity concentration obtained by the two methods was within the limit of the combined standard uncertainty of the difference of these two results. © 2013 Published by Elsevier Ltd.

Low-dose cone-beam CT via raw counts domain low-signal correction schemes: Performance assessment and task-based parameter optimization (Part II. Task-based parameter optimization).

PubMed

Gomez-Cardona, Daniel; Hayes, John W; Zhang, Ran; Li, Ke; Cruz-Bastida, Juan Pablo; Chen, Guang-Hong

2018-05-01

Different low-signal correction (LSC) methods have been shown to efficiently reduce noise streaks and noise level in CT to provide acceptable images at low-radiation dose levels. These methods usually result in CT images with highly shift-variant and anisotropic spatial resolution and noise, which makes the parameter optimization process highly nontrivial. The purpose of this work was to develop a local task-based parameter optimization framework for LSC methods. Two well-known LSC methods, the adaptive trimmed mean (ATM) filter and the anisotropic diffusion (AD) filter, were used as examples to demonstrate how to use the task-based framework to optimize filter parameter selection. Two parameters, denoted by the set P, for each LSC method were included in the optimization problem. For the ATM filter, these parameters are the low- and high-signal threshold levels p l and p h ; for the AD filter, the parameters are the exponents δ and γ in the brightness gradient function. The detectability index d' under the non-prewhitening (NPW) mathematical observer model was selected as the metric for parameter optimization. The optimization problem was formulated as an unconstrained optimization problem that consisted of maximizing an objective function d'(P), where i and j correspond to the i-th imaging task and j-th spatial location, respectively. Since there is no explicit mathematical function to describe the dependence of d' on the set of parameters P for each LSC method, the optimization problem was solved via an experimentally measured d' map over a densely sampled parameter space. In this work, three high-contrast-high-frequency discrimination imaging tasks were defined to explore the parameter space of each of the LSC methods: a vertical bar pattern (task I), a horizontal bar pattern (task II), and a multidirectional feature (task III). Two spatial locations were considered for the analysis, a posterior region-of-interest (ROI) located within the noise streaks region and an anterior ROI, located further from the noise streaks region. Optimal results derived from the task-based detectability index metric were compared to other operating points in the parameter space with different noise and spatial resolution trade-offs. The optimal operating points determined through the d' metric depended on the interplay between the major spatial frequency components of each imaging task and the highly shift-variant and anisotropic noise and spatial resolution properties associated with each operating point in the LSC parameter space. This interplay influenced imaging performance the most when the major spatial frequency component of a given imaging task coincided with the direction of spatial resolution loss or with the dominant noise spatial frequency component; this was the case of imaging task II. The performance of imaging tasks I and III was influenced by this interplay in a smaller scale than imaging task II, since the major frequency component of task I was perpendicular to imaging task II, and because imaging task III did not have strong directional dependence. For both LSC methods, there was a strong dependence of the overall d' magnitude and shape of the contours on the spatial location within the phantom, particularly for imaging tasks II and III. The d' value obtained at the optimal operating point for each spatial location and imaging task was similar when comparing the LSC methods studied in this work. A local task-based detectability framework to optimize the selection of parameters for LSC methods was developed. The framework takes into account the potential shift-variant and anisotropic spatial resolution and noise properties to maximize the imaging performance of the CT system. Optimal parameters for a given LSC method depend strongly on the spatial location within the image object. © 2018 American Association of Physicists in Medicine.

75 FR 44811 - Sunshine Act Meeting of the Board of Directors and Five Board Committees

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-29

... impediments to development of numerical criteria for the measurement of LSC performance Briefing on how the..., including identification of possible impediments to development of numerical criteria for the measurement of... on Resolution 2010-XXX regarding future amendments to the LSC Accounting Manual 14. Consider and act...

Comparative Toxicity of Louisiana Sweet Crude Oil (LSC) and Chemically Dispersed LSC to Two Gulf of Mexico Aquatic Test Species.

EPA Science Inventory

Environmental Protection Agency released peer reviewed results from the second phase of its independent toxicity testing on mixtures of eight oil dispersants with Louisiana Sweet Crude Oil. EPA conducted the tests as part of an effort to ensure that EPA decisions remain grounded ...

Double Mapping in Metaphorical Expressions of Thought and Communication in Catalan Sign Language (LSC)

ERIC Educational Resources Information Center

Jarque, Maria-Josep

2005-01-01

This document illustrates that mental functioning and communication in Catalan Sign Language (LSC) are conceptual through metaphorical projection of bodily experiences. The data in this document show how concepts are grasped, put on student's heads, exchanged, manipulated, and so on, constituting instantiations of the basic metaphors: ideas are…

Aberrant RNA splicing and mutations in spliceosome complex in acute myeloid leukemia.

PubMed

Zhou, Jianbiao; Chng, Wee-Joo

2017-01-01

The spliceosome, the cellular splicing machinery, regulates RNA splicing of messenger RNA precursors (pre-mRNAs) into maturation of protein coding RNAs. Recurrent mutations and copy number changes in genes encoding spliceosomal proteins and splicing regulatory factors have tumor promoting or suppressive functions in hematological malignancies, as well as some other cancers. Leukemia stem cell (LSC) populations, although rare, are essential contributors of treatment failure and relapse. Recent researches have provided the compelling evidence that link the erratic spicing activity to the LSC phenotype in acute myeloid leukemia (AML). In this article, we describe the diverse roles of aberrant splicing in hematological malignancies, particularly in AML and their contributions to the characteristics of LSC. We review these promising strategies to exploit the addiction of aberrant spliceosomal machinery for anti-leukemic therapy with aim to eradicate LSC. However, given the complexity and plasticity of spliceosome and not fully known functions of splicing in cancer, the challenges facing the development of the therapeutic strategies targeting RAN splicing are highlighted and future directions are discussed too.

On the equivalence of spherical splines with least-squares collocation and Stokes's formula for regional geoid computation

NASA Astrophysics Data System (ADS)

Ophaug, Vegard; Gerlach, Christian

2017-11-01

This work is an investigation of three methods for regional geoid computation: Stokes's formula, least-squares collocation (LSC), and spherical radial base functions (RBFs) using the spline kernel (SK). It is a first attempt to compare the three methods theoretically and numerically in a unified framework. While Stokes integration and LSC may be regarded as classic methods for regional geoid computation, RBFs may still be regarded as a modern approach. All methods are theoretically equal when applied globally, and we therefore expect them to give comparable results in regional applications. However, it has been shown by de Min (Bull Géod 69:223-232, 1995. doi: 10.1007/BF00806734) that the equivalence of Stokes's formula and LSC does not hold in regional applications without modifying the cross-covariance function. In order to make all methods comparable in regional applications, the corresponding modification has been introduced also in the SK. Ultimately, we present numerical examples comparing Stokes's formula, LSC, and SKs in a closed-loop environment using synthetic noise-free data, to verify their equivalence. All agree on the millimeter level.

Re-Os isotope and platinum group elements of a FOcal ZOne mantle source, Louisville Seamounts Chain, Pacific ocean

NASA Astrophysics Data System (ADS)

Tejada, Maria Luisa G.; Hanyu, Takeshi; Ishikawa, Akira; Senda, Ryoko; Suzuki, Katsuhiko; Fitton, Godfrey; Williams, Rebecca

2015-02-01

The Louisville Seamount Chain (LSC) is, besides the Hawaiian-Emperor Chain, one of the longest-lived hotspot traces. We report here the first Re-Os isotope and platinum group element (PGE) data for Canopus, Rigil, and Burton Guyots along the chain, which were drilled during IODP Expedition 330. The LSC basalts possess (187Os/188Os)i = 0.1245-0.1314 that are remarkably homogeneous and do not vary with age. A Re-Os isochron age of 64.9 ± 3.2 Ma was obtained for Burton seamount (the youngest of the three seamounts drilled), consistent with 40Ar-39Ar data. Isochron-derived initial 187Os/188Os ratio of 0.1272 ± 0.0008, together with data for olivines (0.1271-0.1275), are within the estimated primitive mantle values. This (187Os/188Os)i range is similar to those of Rarotonga (0.124-0.139) and Samoan shield (0.1276-0.1313) basalts and lower than those of Cook-Austral (0.136-0.155) and Hawaiian shield (0.1283-0.1578) basalts, suggesting little or no recycled component in the LSC mantle source. The PGE data of LSC basalts are distinct from those of oceanic lower crust. Variation in PGE patterns can be largely explained by different low degrees of melting under sulfide-saturated conditions of the same relatively fertile mantle source, consistent with their primitive mantle-like Os and primordial Ne isotope signatures. The PGE patterns and the low 187Os/188Os composition of LSC basalts contrast with those of Ontong Java Plateau (OJP) tholeiites. We conclude that the Re-Os isotope and PGE composition of LSC basalts reflect a relatively pure deep-sourced common mantle sampled by some ocean island basalts but is not discernible in the composition of OJP tholeiites.

Guidelines for improving the reproducibility of quantitative multiparameter immunofluorescence measurements by laser scanning cytometry on fixed cell suspensions from human solid tumors.

PubMed

Shackney, Stanley; Emlet, David R; Pollice, Agnese; Smith, Charles; Brown, Kathryn; Kociban, Deborah

2006-01-01

Laser scanning Cytometry (LSC) is a versatile technology that makes it possible to perform multiple measurements on individual cells and correlate them cell by cell with other cellular features. It would be highly desirable to be able to perform reproducible, quantitative, correlated cell-based immunofluorescence studies on individual cells from human solid tumors. However, such studies can be challenging because of the presence of large numbers of cell aggregates and other confounding factors. Techniques have been developed to deal with cell aggregates in data sets collected by LSC. Experience has also been gained in addressing other key technical and methodological issues that can affect the reproducibility of such cell-based immunofluorescence measurements. We describe practical aspects of cell sample collection, cell fixation and staining, protocols for performing multiparameter immunofluorescence measurements by LSC, use of controls and reference samples, and approaches to data analysis that we have found useful in improving the accuracy and reproducibility of LSC data obtained in human tumor samples. We provide examples of the potential advantages of LSC in examining quantitative aspects of cell-based analysis. Improvements in the quality of cell-based multiparameter immunofluorescence measurements make it possible to extract useful information from relatively small numbers of cells. This, in turn, permits the performance of multiple multicolor panels on each tumor sample. With links among the different panels that are provided by overlapping measurements, it is possible to develop increasingly more extensive profiles of intracellular expression of multiple proteins in clinical samples of human solid tumors. Examples of such linked panels of measurements are provided. Advances in methodology can improve cell-based multiparameter immunofluorescence measurements on cell suspensions from human solid tumors by LSC for use in prognostic and predictive clinical applications. Copyright (c) 2005 Wiley-Liss, Inc.

Change Detection via Selective Guided Contrasting Filters

NASA Astrophysics Data System (ADS)

Vizilter, Y. V.; Rubis, A. Y.; Zheltov, S. Y.

2017-05-01

Change detection scheme based on guided contrasting was previously proposed. Guided contrasting filter takes two images (test and sample) as input and forms the output as filtered version of test image. Such filter preserves the similar details and smooths the non-similar details of test image with respect to sample image. Due to this the difference between test image and its filtered version (difference map) could be a basis for robust change detection. Guided contrasting is performed in two steps: at the first step some smoothing operator (SO) is applied for elimination of test image details; at the second step all matched details are restored with local contrast proportional to the value of some local similarity coefficient (LSC). The guided contrasting filter was proposed based on local average smoothing as SO and local linear correlation as LSC. In this paper we propose and implement new set of selective guided contrasting filters based on different combinations of various SO and thresholded LSC. Linear average and Gaussian smoothing, nonlinear median filtering, morphological opening and closing are considered as SO. Local linear correlation coefficient, morphological correlation coefficient (MCC), mutual information, mean square MCC and geometrical correlation coefficients are applied as LSC. Thresholding of LSC allows operating with non-normalized LSC and enhancing the selective properties of guided contrasting filters: details are either totally recovered or not recovered at all after the smoothing. These different guided contrasting filters are tested as a part of previously proposed change detection pipeline, which contains following stages: guided contrasting filtering on image pyramid, calculation of difference map, binarization, extraction of change proposals and testing change proposals using local MCC. Experiments on real and simulated image bases demonstrate the applicability of all proposed selective guided contrasting filters. All implemented filters provide the robustness relative to weak geometrical discrepancy of compared images. Selective guided contrasting based on morphological opening/closing and thresholded morphological correlation demonstrates the best change detection result.

Some lumbar sympathetic neurons develop a glutamatergic phenotype after peripheral axotomy with a note on VGLUT2-positive perineuronal baskets

PubMed Central

Brumovsky, Pablo R.; Seroogy, Kim B.; Lundgren, Kerstin H.; Watanabe, Masahiko; Hökfelt, Tomas; Gebhart, G. F.

2011-01-01

Glutamate is the main excitatory neurotransmitter in the nervous system, including in primary afferent neurons. However, to date a glutamatergic phenotype of autonomic neurons has not been described. Therefore, we explored the expression of vesicular glutamate transporters (VGLUTs) type 1, 2 and 3 in lumbar sympathetic chain (LSC) and major pelvic ganglion (MPG) of naïve BALB/C mice, as well as after pelvic nerve axotomy (PNA), using immunohistochemistry and in situ hybridization. Colocalization with activating transcription factor-3 (ATF-3), tyrosine hydroxylase (TH), vesicular acetylcholine transporter (VAChT) and calcitonin generelated peptide was also examined. Sham-PNA, sciatic nerve axotomy (SNA) or naïve mice were included. In naïve mice, VGLUT2-like immunoreactivity (LI) was only detected in fibers and varicosities in LSC and MPG; no ATF-3-immunoreactive (IR) neurons were visible. In contrast, PNA induced upregulation of VGLUT2 protein and transcript, as well as of ATF-3-LI in subpopulations of LSC neurons. Interestingly, VGLUT2-IR LSC neurons coexpressed ATF-3, and often lacked the noradrenergic marker TH. SNA only increased VGLUT2 protein and transcript in scattered LSC neurons. Neither PNA nor SNA upregulated VGLUT2 in MPG neurons. We also found perineuronal baskets immunoreactive either for VGLUT2 or the acetylcholinergic marker VAChT in non-PNA MPGs, usually around TH-IR neurons. VGLUT1-LI was restricted to some varicosities in MPGs, was absent in LSCs, and remained largely unaffected by PNA or SNA. This was confirmed by the lack of expression of VGLUT1 or VGLUT3 mRNAs in LSCs, even after PNA or SNA. Taken together, axotomy of visceral and non-visceral nerves results in a glutamatergic phenotype of some LSC neurons. In addition, we show previously non-described MPG perineuronal glutamatergic baskets. PMID:21596036

Leukotriene signaling via ALOX5 and cysteinyl leukotriene receptor 1 is dispensable for in vitro growth of CD34+CD38- stem and progenitor cells in chronic myeloid leukemia.

PubMed

Dolinska, Monika; Piccini, Alexandre; Wong, Wan Man; Gelali, Eleni; Johansson, Anne-Sofie; Klang, Johannis; Xiao, Pingnan; Yektaei-Karin, Elham; Strömberg, Ulla Olsson; Mustjoki, Satu; Stenke, Leif; Ekblom, Marja; Qian, Hong

2017-08-19

Tyrosine kinase inhibitors targeting the BCR-ABL oncoprotein in chronic myeloid leukemia (CML) are remarkably effective inducing deep molecular remission in most patients. However, they are less effective to eradicate the leukemic stem cells (LSC), resulting in disease persistence. Therefore, there is great need to develop novel therapeutic strategies to specifically target the LSC. In an experimental mouse CML model system, the leukotriene pathway, and specifically, the expression ALOX5, encoding 5-lipoxygenase (5-LO), has been reported as a critical regulator of the LSC. Based on these results, the 5-LO inhibitor zileuton has been introduced in clinical trials as a therapeutic option to target the LSC although its effect on primary human CML LSC has not been studied. We have here by using multiplex single cell PCR analyzed the expression of the mediators of the leukotriene pathway in bone marrow (BM) BCR-ABL + CD34 + CD38 - cells at diagnosis, and found low or undetectable expression of ALOX5. In line with this, zileuton did not exert significant overall growth inhibition in the long-term culture-initiating cell (LTC-IC) and colony (CFU-C) assays of BM CD34 + CD38 - cells from 7 CML patients. The majority of the single leukemic BCR-ABL + CD34 + CD38 - cells expressed cysteinyl leukotriene receptors CYSLT1 and CYSLT2. However, montelukast, an inhibitor of CYSLT1, also failed to significantly suppress CFU-C and LTC-IC growth. These findings indicate that targeting ALOX5 or CYSLT1 signaling with leukotriene antagonists, introduced into the clinical practice primarily as prophylaxis and treatment for asthma, may not be a promising pharmacological strategy to eradicate persisting LSC in CML patients. Copyright © 2017 The Author(s). Published by Elsevier Inc. All rights reserved.

Deep subsurface microbiology of 64-71 million year old inactive seamounts along the Louisville Seamount Chain

NASA Astrophysics Data System (ADS)

Sylvan, J. B.; Morono, Y.; Grim, S.; Inagaki, F.; Edwards, K. J.

2013-12-01

One of the objectives of IODP Expedition 330, Louisville Seamount Trail, was to sample and learn about the subsurface biosphere in the Louisville Seamount Chain (LSC). Seamounts are volcanic constructs that are ubiquitous along the seafloor - models suggest there are >100,000 seamounts of >1 km in height globally (Wessel et al., 2010). Therefore, knowledge about microbiology in the LSC subsurface can broadly be interpreted as representative of much the seafloor. In addition, despite the fact that the vast majority of the sea floor is comprised of crust >10 Ma, the majority of work to date has focused on young sites with active hydrology. Our presentation summarizes work focusing on subsurface microbiology from two different LSC seamounts: holes U1374A (65-71 Ma) and U1376A (64 Ma). We here present data for microbial biomass in the LSC subsurface using a method we developed to quantify microbial biomass in subseafloor ocean crust. We also present results from pyrotag analysis of 15 samples from holes U1374A and holes U1376A, representing several different lithologies from 40-491 meters below seafloor (mbsf) in hole U1374A and from 29-174 mbsf in hole U1376A. Finally, we present preliminary analysis of metagenomic sequencing from three of the samples from Hole U1376A. Biomass was low in the subsurface of both seamounts, ranging from below detection to ~104 cells cm-3. Bacteria comprised >99% of the prokaryotic community in LSC subsurface samples, therefore, bacterial diversity was assessed through 454 pyrosequencing of the V4V6 region of the 16S rRNA gene. Rarefaction analysis indicates that bacterial communities from the LSC subsurface are low diversity, on the order of a few hundred operational taxonomic units per sample. The phyla Actinobacteria, Bacteroidetes, Firmicutes and the classes α-, β- and γ-Proteobacteria are most abundant in the LSC subsurface. Within these, the orders Actinomycetales, Sphingobacteriales, Bacillales and Burkholderiales are the most common. Samples from different lithologies in hole U1374A grouped together, indicating more similarity to each other than to samples from hole U1376A. However, samples from different lithologies in hole U1376A were not similar to other samples from the same site, indicating some differences in the microbial communities between the two seamounts. Preliminary analysis of the metagenomic data will provide further assessment of community structure and reveal likely metabolisms present in the LSC subsurface. Altogether, the biomass data, pyrotag analysis and metagenomic sequencing provide a well-balanced analysis of subsurface microbiology in an old oceanic crustal environment. Wessel, P., Sandwell, D. T. & Kim, S. S. (2010). The Global Seamount Census. Oceanography 23, 24-33.

Anticancer effects on leiomyosarcoma-bearing Wistar rats after electromagnetic radiation of resonant radiofrequencies.

PubMed

Avdikos, Antonios; Karkabounas, Spyridon; Metsios, Apostolos; Kostoula, Olga; Havelas, Konstantinos; Binolis, Jayne; Verginadis, Ioannis; Hatziaivazis, George; Simos, Ioannis; Evangelou, Angelos

2007-01-01

In the present study, the effects of a resonant low intensity static electromagnetic field (EMF), causing no thermal effects, on Wistar rats have been investigated. Sarcoma cell lines were isolated from leiomyosarcoma tumors induced in Wistar rats by the subcutaneous (s.c) injection of 3,4-benzopyrene. Furthermore, smooth muscle cells (SMC) were isolated from the aorta of Wistar rats and cultivated. Either leiomyosarcoma cells (LSC) or SMC were used to record a number of characteristic resonant radiofrequencies, in order to determine the specific electromagnetic fingerprint spectrum for each cell line. These spectra were used to compose an appropriate algorithm, which transforms the recorded radiofrequencies to emitted ones. The isolated LSC were cultured and then exposed to a resonant low intensity radiofrequency EMF (RF-EMF), at frequencies between 10 kHz to 120 kHz of the radiowave spectrum. The exposure lasted 45 consecutive minutes daily, for two consecutive days. Three months old female Wistar rats were inoculated with exposed and non-exposed to EMF LSC (4 x 10(6) LCS for animal). Inoculated with non-exposed to EMF cells animals were then randomly separated into three Groups. The first Group was sham exposed to the resonant EMF (control Group-CG), the second Group after the inoculation of LSC and appearance of a palpable tumor mass, was exposed to a non-resonant EMF radiation pattern, for 5 h per day till death of all animals (experimental control Group-ECG). The third Group of animals after inoculation of LSC and the appearance of a palpable tumor mass, was exposed to the resonant EMF radiation for 5 h per day, for a maximum of 60 days (experimental Group-I, EG-I). A fourth Group of animals was inoculated with LSC exposed to EMF irradiation and were not further exposed to irradiation (experimental Group-II, EG-II). Tumor induction was 100% in all Groups studied and all tumors were histologically identified as leiomyosarcomas. In the case of the EG-I, a number of tumors were completely regretted (final tumor induction: 66%). Both Groups of animals inoculated with exposed or non-exposed to the EMF LSC, (EG-I and EG-II, respectively) demonstrated a significant prolongation of the survival time and a lower tumor growth rate, in comparison to the control Group (CG) and the experimental control Group (ECG). However, the survival time of EG-I animals was found to be significantly longer and tumor growth rate significantly lower compared to EG-II animals. In conclusion, our results indicate a specific anticancer effect of resonant EMF irradiation. These results may possibly be attributed to (a) the duration of exposure of LSC and (b) the exposure of the entire animal to this irradiation.

The Verbal System of Catalan Sign Language (LSC)

ERIC Educational Resources Information Center

Morales-Lopez, Esperanza; Boldu-Menasanch, Rosa Maria; Alonso-Rodriguez, Jesus Amador; Gras-Ferrer, Victoria; Rodriguez-Gonzalez, Maria Angeles

2005-01-01

This article describes the predicative verbal system of Catalan Sign Language (LSC) as it is used by Deaf people in the province of Barcelona. We also present a historical perspective of the research on this topic, which provides insight into the changes that have taken place over the last few decades in sign language linguistics. The principal…

3 CFR 8397 - Proclamation 8397 of July 23, 2009. 35th Anniversary of the Legal Services Corporation, 2009

Code of Federal Regulations, 2010 CFR

2010-01-01

... years during which the LSC has moved our Nation and our legal system towards greater equality. The LSC... of the Legal Services Corporation, 2009 8397 Proclamation 8397 Presidential Documents Proclamations Proclamation 8397 of July 23, 2009 Proc. 8397 35th Anniversary of the Legal Services Corporation, 2009By the...

75 FR 21044 - Sunshine Act Meeting of the Board of Directors Search Committee for LSC President; Notice

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-22

... LEGAL SERVICES CORPORATION Sunshine Act Meeting of the Board of Directors Search Committee for LSC President; Notice Time and Date: The Presidential Search Committee of the Legal Services Corporation's Board.... 2. Consider and act on draft Request for Proposals for executive search firms. 3. Public Comment. 4...

Survey of Local School Council Members, 1992: A Report on the Findings.

ERIC Educational Resources Information Center

Mueller, Siegfried G.

This report is based on a survey of local school council (LSC) members in Chicago (Illinois) that was conducted in 1992 to determine and share the thoughts of LSC members on planning for school improvements and educational change, implementing policies, training, and fulfilling responsibilities and duties. Nearly 850 council members responded.…

Reorientations of the large-scale flow in turbulent convection in a cube

NASA Astrophysics Data System (ADS)

Foroozani, N.; Niemela, J. J.; Armenio, V.; Sreenivasan, K. R.

2017-03-01

Large-eddy simulations of turbulent Rayleigh-Bénard convection were conducted for a fluid of Prandtl number Pr=0.7 confined in a cube, for Rayleigh numbers of 106 and 108. The model solves the unsteady Navier-Stokes equations under the Boussinesq approximation, using a dynamic Smagorinsky model with a Lagrangian averaging technique for the subgrid terms. Under fully developed conditions the flow topology is characterized by a large-scale circulation (LSC) developing in a plane containing one of the diagonals of the cell, while two counter-rotating vortices consequently develop in the other diagonal plane, resulting in a strong inflow at the horizontal midplane. This flow structure is not static, with the LSC undergoing nonperiodic reorientations, or switching, between the two diagonal planes; hence, we supplement the observations of the three-dimensional time-averaged flow structures with single point measurements (time series) to shed light on the dynamics of the reorientations. For all observations, this switching results from a lateral rotation of the LSC in which some finite time spent in a transient state where the large-scale circulation is parallel to one set of side walls; there are, importantly, no observations consistent with so-called cessations of the LSC, in which it decays and then reforms in another plane without such a rotation. The average switching rate for the LSC is in excellent agreement with the results of Bai et al. [K. Bai, D. Ji, and E. Brown, Phys. Rev. E 93, 023117 (2016), 10.1103/PhysRevE.93.023117].

Reliability and Validity of the Korean Version of the Lifetime Stressor Checklist-Revised in Psychiatric Outpatients with Anxiety or Depressive Disorders.

PubMed

Choi, Kang Rok; Kim, Daeho; Jang, Eun Young; Bae, Hwallip; Kim, Seok Hyeon

2017-01-01

Traumatic events and adverse stressful experiences are major etiological factors in a wide variety of physical and mental disorders. Developing psychological instruments that can be easily administered and that have good psychometric properties have become an integral part for research and practice. This study investigated the reliability and validity of the Korean version of the Lifetime Stressor Checklist-Revised (LSC-R) in a consecutive sample of psychiatric outpatients. The LSC-R is a 30-item self-reporting questionnaire examining lifetime traumatic and non-traumatic stressors. A final sample of 258 outpatients with anxiety or depressive disorders was recruited at the psychiatric department of a university-affiliated teaching hospital. Self-reported data included the Life Events Checklist (LEC), the Zung Self-Rating Depression and Anxiety Scales, and the Impact of Events Scale-Revised, in addition to the LSC-R. A convenience sample of 50 college students completed the LSC-R on two occasions separated by a three week-interval for test-retest reliability. Mean kappa for temporal stability was high (κ=0.651) and Cronbach alpha was moderate (α=0.724). Convergent validity was excellent with corresponding items on the LEC. Concurrent validity was good for symptoms of post-traumatic stress disorder, depression, and anxiety. An exploratory factor analysis revealed that 11 factors explained 64.3 % of the total variance. This study demonstrated good psychometric properties of the Korean version of the LSC-R, further supporting its use in clinical research and practice with a Korean speaking population.

Reorientations of the large-scale flow in turbulent convection in a cube.

PubMed

Foroozani, N; Niemela, J J; Armenio, V; Sreenivasan, K R

2017-03-01

Large-eddy simulations of turbulent Rayleigh-Bénard convection were conducted for a fluid of Prandtl number Pr=0.7 confined in a cube, for Rayleigh numbers of 10^{6} and 10^{8}. The model solves the unsteady Navier-Stokes equations under the Boussinesq approximation, using a dynamic Smagorinsky model with a Lagrangian averaging technique for the subgrid terms. Under fully developed conditions the flow topology is characterized by a large-scale circulation (LSC) developing in a plane containing one of the diagonals of the cell, while two counter-rotating vortices consequently develop in the other diagonal plane, resulting in a strong inflow at the horizontal midplane. This flow structure is not static, with the LSC undergoing nonperiodic reorientations, or switching, between the two diagonal planes; hence, we supplement the observations of the three-dimensional time-averaged flow structures with single point measurements (time series) to shed light on the dynamics of the reorientations. For all observations, this switching results from a lateral rotation of the LSC in which some finite time spent in a transient state where the large-scale circulation is parallel to one set of side walls; there are, importantly, no observations consistent with so-called cessations of the LSC, in which it decays and then reforms in another plane without such a rotation. The average switching rate for the LSC is in excellent agreement with the results of Bai et al. [K. Bai, D. Ji, and E. Brown, Phys. Rev. E 93, 023117 (2016)PLEEE81539-375510.1103/PhysRevE.93.023117].

78 FR 27341 - Restrictions on Legal Assistance With Respect to Criminal Proceedings in Tribal Courts

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-10

... under the LSC's adoption of the Freedom of Information Act, 42 U.S.C. 2996d(g), and the LSC regulation... maximum jail sentence that any tribal court may impose from one to three years for any single offense... a defendant is indigent, providing the defendant with a licensed defense attorney at the tribe's...

Carbon footprint of robotically-assisted laparoscopy, laparoscopy and laparotomy: a comparison.

PubMed

Woods, Demetrius L; McAndrew, Thomas; Nevadunsky, Nicole; Hou, June Y; Goldberg, Gary; Yi-Shin Kuo, Dennis; Isani, Sara

2015-12-01

To date there have been no comprehensive, comparative assessments of the environmental impact of surgical modalities. Our study seeks to quantify and compare the total greenhouse gas emissions, or 'carbon footprint', attributable to three surgical modalities. A review of 150 staging procedures, employing laparotomy (LAP), conventional laparoscopy (LSC) or robotically-assisted laparoscopy (RA-LSC), was performed. The solid waste generated (kg) and energy consumed (kWh) during each case were quantified and converted into their equivalent mass of carbon dioxide (kg CO(2) e) release into the environment. The carbon footprint is the sum of the waste production and energy consumption during each surgery (kg CO(2) e). The total carbon footprint of a RA-LSC procedure is 40.3 kg CO(2) e/patient (p < 0.01). This represents a 38% increase over that of LSC (29.2 kg CO(2) e/patient; p < 0.01) and a 77% increase over LAP (22.7 kg CO(2) e/patient; p < 0.01). Our results provide clinicians, administrators and policy-makers with knowledge of the environmental impact of their decisions to facilitate adoption of sustainable practices. Copyright © 2015 John Wiley & Sons, Ltd.

Development of an Ultra-Low Background Liquid Scintillation Counter for Trace Level Analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Erchinger, Jennifer L.; Orrell, John L.; Aalseth, Craig E.

2015-09-01

Low-level liquid scintillation counting (LSC) has been established as one of the radiation detection techniques useful in elucidating environmental processes and environmental monitoring around nuclear facilities. The Ultra-Low Background Liquid Scintillation Counter (ULB-LSC) under construction in the Shallow Underground Laboratory at Pacific Northwest National Laboratory aims to further reduce the MDAs and/or required sample processing. Through layers of passive shielding in conjunction with an active veto and 30 meters water equivalent overburden, the background reduction is expected to be 10 to 100 times below typical analytic low-background liquid scintillation systems. Simulations have shown an expected background of around 14 countsmore » per day. A novel approach to the light collection will use a coated hollow light guide cut into the inner copper shielding. Demonstration LSC measurements will show low-energy detection, spectral deconvolution, and alpha/beta discrimination capabilities, from trials with standards of tritium, strontium-90, and actinium-227, respectively. An overview of the system design and expected demonstration measurements will emphasize the potential applications of the ULB-LSC in environmental monitoring for treaty verification, reach-back sample analysis, and facility inspections.« less

Monte Carlo ray-tracing simulations of luminescent solar concentrators for building integrated photovoltaics

NASA Astrophysics Data System (ADS)

Leow, Shin Woei; Corrado, Carley; Osborn, Melissa; Carter, Sue A.

2013-09-01

Luminescent solar concentrators (LSCs) have the ability to receive light from a wide range of angles, concentrating the captured light onto small photo active areas. This enables greater incorporation of LSCs into building designs as windows, skylights and wall claddings in addition to rooftop installations of current solar panels. Using relatively cheap luminescent dyes and acrylic waveguides to effect light concentration onto lesser photovoltaic (PV) cells, there is potential for this technology to approach grid price parity. We employ a panel design in which the front facing PV cells collect both direct and concentrated light ensuring a gain factor greater than one. This also allows for flexibility in determining the placement and percentage coverage of PV cells during the design process to balance reabsorption losses against the power output and level of light concentration desired. To aid in design optimization, a Monte-Carlo ray tracing program was developed to study the transport of photons and loss mechanisms in LSC panels. The program imports measured absorption/emission spectra and transmission coefficients as simulation parameters with interactions of photons in the panel determined by comparing calculated probabilities with random number generators. LSC panels with multiple dyes or layers can also be simulated. Analysis of the results reveals optimal panel dimensions and PV cell layouts for maximum power output for a given dye concentration, absorbtion/emission spectrum and quantum efficiency.

Numerical Study of Three Dimensional Effects in Longitudinal Space-Charge Impedance

DOE Office of Scientific and Technical Information (OSTI.GOV)

Halavanau, A.; Piot, P.

2015-06-01

Longitudinal space-charge (LSC) effects are generally considered as detrimental in free-electron lasers as they can seed instabilities. Such “microbunching instabilities” were recently shown to be potentially useful to support the generation of broadband coherent radiation pulses [1, 2]. Therefore there has been an increasing interest in devising accelerator beamlines capable of sustaining this LSC instability as a mechanism to produce a coherent light source. To date most of these studies have been carried out with a one-dimensional impedance model for the LSC. In this paper we use a N-body “Barnes-Hut” algorithm [3] to simulate the 3D space charge force inmore » the beam combined with elegant [4] and explore the limitation of the 1D model often used« less

Autophagy mediates cell cycle response by regulating nucleocytoplasmic transport of PAX6 in limbal stem cells under ultraviolet-A stress

PubMed Central

Laggner, Maria; Pollreisz, Andreas; Schmidinger, Gerald; Schmidt-Erfurth, Ursula; Chen, Ying-Ting

2017-01-01

Limbal stem cells (LSC) account for homeostasis and regeneration of corneal epithelium. Solar ultraviolet A (UVA) is the major source causing oxidative damage in the ocular surface. Autophagy, a lysosomal degradation mechanism, is essential for physiologic function and stress defense of stem cells. PAX6, a master transcription factor governing corneal homeostasis by regulating cell cycle and cell fate of LSC, responds to oxidative stress by nucleocytoplasmic shuttling. Impaired autophagy and deregulated PAX6 have been reported in oxidative stress-related ocular surface disorders. We hypothesize a functional role for autophagy and PAX6 in LSC’s stress response to UVA. Therefore, human LSC colonies were irradiated with a sub-lethal dose of UVA and autophagic activity and intracellular reactive oxygen species (ROS) were measured by CYTO-ID assay and CM-H2DCFDA live staining, respectively. Following UVA irradiation, the percentage of autophagic cells significantly increased in LSC colonies while intracellular ROS levels remained unaffected. siRNA-mediated knockdown (KD) of ATG7 abolished UVA-induced autophagy and led to an excessive accumulation of ROS. Upon UVA exposure, LSCs displayed nuclear-to-cytoplasmic translocation of PAX6, while ATG7KD or antioxidant pretreatment largely attenuated the intracellular trafficking event. Immunofluorescence showing downregulation of proliferative marker PCNA and induction of cell cycle regulator p21 indicates cell cycle arrest in UVA-irradiated LSC. Abolishing autophagy, adenoviral-assisted restoration of nuclear PAX6 or antioxidant pretreatment abrogated the UVA-induced cell cycle arrest. Adenoviral expression of an ectopic PAX gene, PAX7, did not affect UVA cell cycle response. Furthermore, knocking down PAX6 attenuated the cell cycle progression of irradiated ATG7KD LSC by de-repressing p21 expression. Collectively, our data suggest a crosstalk between autophagy and PAX6 in regulating cell cycle response of ocular progenitors under UVA stress. Autophagy deficiency leads to impaired intracellular trafficking of PAX6, perturbed redox balance and uncurbed cell cycle progression in UVA-stressed LSCs. The coupling of autophagic machinery and PAX6 in cell cycle regulation represents an attractive therapeutic target for hyperproliferative ocular surface disorders associated with solar radiation. PMID:28700649

Introduction of a computer-based surgical platform in the surgical care of patients with newly diagnosed uterine cancer: outcomes and impact on approach.

PubMed

Leitao, Mario M; Briscoe, Gabriel; Santos, Kevin; Winder, Abigail; Jewell, Elizabeth L; Hoskins, William J; Chi, Dennis S; Abu-Rustum, Nadeem R; Sonoda, Yukio; Brown, Carol L; Levine, Douglas A; Barakat, Richard R; Gardner, Ginger J

2012-05-01

To assess the introduction of computer-based surgery (ie, robotic surgery [RBT]) in the treatment of patients with newly diagnosed uterine cancer. We identified all patients who presented to our institution for initial surgical care of newly diagnosed uterine cancer from 5/1/07-12/31/10. Perioperative outcomes of laparotomy cases were compared to those of laparoscopic (LSC) or RBT cases. Complications within 30 days of surgery were graded. Of 752 patients, the planned approach was laparotomy in 103 (14%), LSC in 302 (40%), and RBT in 347 (46%). The rate of laparotomy for any reason (planned or converted) was 39% in 2007 compared to 18% in 2010 (P<0.001). Preoperative characteristics for LSC and RBT cases were similar, except 10% versus 15%, respectively, were morbidly obese (P=0.049). The extent of procedure, total nodal counts, and overall complications were similar between the LSC and RBT cases. The median length of stay was shorter for RBT cases (P<0.001). The median total room and operative times were longer for RBT cases (P<0.001), mainly due to cases in which the surgeon had less than ~40 RBT cases of experience. Robotics can be efficiently introduced into the surgical care of patients with newly diagnosed uterine cancers. RBT cases require the same operative times as LSC cases after accounting for the 40-case learning curve. Both approaches result in similar excellent patient outcomes and remain reasonable approaches for this disease. The introduction of robotics may lead to further reduction in the rate of laparotomy. Copyright © 2012 Elsevier Inc. All rights reserved.

Assessment of heat shock protein (HSP60, HSP72, HSP90, and HSC70) expression in cultured limbal stem cells following air lifting

PubMed Central

Mohammadi, Parvaneh; Daryadel, Arezoo; Baharvand, Hossein

2010-01-01

Objectives The aim of this study is to create an ex vivo model to examine the expression of major heat-shock protein (HSP) families; HSP60, HSP72, and HSP90, and heat-shock cognate 70 (HCS70) at the mRNA and protein level in differentiating corneal cells from limbal stem cells (LSC) following air exposure. Methods Limbal biopsies taken from cadaveric normal human limbus were cultivated as explants on human amniotic membrane (HAM) and plastic dish (PD). Corneal differentiation was induced by air lifting for 16 days. The expression of putative LSC markers (P63 and ATP-binding cassette G2 [ABCG2]), corneal markers (keratin 3 [K3/12] and connexin 43 [CX43]), and HSP60, HSP72, HSP90, and HSC70 were tested by RT–PCR, immunofluorescence, and flow cytometry pre- and post-air exposure. Fresh limbal and corneal tissues were used as control groups. Results Air lifting induced corneal differentiation with a decrease in the number of P63+ cells and an increase in the number of K3+/CX43+ cells, which characterized transient amplifying cells (TACs). Moreover, denuded HAM provided a superior niche for LSC proliferation and phenotype maintenance in vitro. Additionally, we have evidence that expressions of HSC70 as well as HSP72 were enhanced through corneal differentiation and HSP90 post-air lifting in vitro and in vivo. HSP60, however, was not detected in either LSC or corneal cells, in vivo and in vitro. Conclusions These results suggest that corneal differentiation following air exposure may regulate HSP72 and HSC70 expression. In addition, HSP72 and HSP90 may protect LSC and corneal cells against oxidative stress. PMID:20806039

The downregulation of microRNA let-7a contributes to the excessive expression of type I collagen in systemic and localized scleroderma.

PubMed

Makino, Katsunari; Jinnin, Masatoshi; Hirano, Ayaka; Yamane, Keitaro; Eto, Mitsuhiko; Kusano, Takamitsu; Honda, Noritoshi; Kajihara, Ikko; Makino, Takamitsu; Sakai, Keisuke; Masuguchi, Shinichi; Fukushima, Satoshi; Ihn, Hironobu

2013-04-15

Systemic and localized scleroderma (SSc and LSc) is characterized by excessive deposition of collagen and tissue fibrosis in the skin. Although they have fundamental common characteristics including autoimmunity, little is known about the exact mechanism that mediates the excessive collagen expression in these disorders. In the current study, we tried to evaluate the possibility that microRNAs (miRNAs) play some roles in the pathogenesis of fibrosis seen in these diseases. miRNA expression patterns were evaluated by miRNA array analysis, real-time PCR, and in situ hybridization. The function of miRNAs in dermal fibroblasts was assessed using miRNA inhibitors, precursors, or protectors. In the mouse model of bleomycin-induced dermal sclerosis, the overexpression of miRNAs was performed by i.p. miRNA injection. We demonstrated let-7a expression was downregulated in SSc and LSc skin both in vivo and in vitro, compared with normal or keloid skin. The inhibition or overexpression of let-7a in human or mouse skin fibroblasts affected the protein expression of type I collagen or luciferase activity of collagen 3'-untranslated region. Also, we found let-7a was detectable and quantitative in the serum and investigated serum let-7a levels in patients with SSc or LSc. let-7a concentration was significantly decreased in these patients, especially in LSc patients. Moreover, we revealed that the intermittent overexpression of let-7a in the skin by i.p. miRNA injection improved the skin fibrosis induced by bleomycin in mice. Investigation of more detailed mechanisms of miRNA-mediated regulation of collagen expression may lead to new therapeutic approaches against SSc and LSc.

Persisting soil drought reduces leaf specific conductivity in Scots pine (Pinus sylvestris) and pubescent oak (Quercus pubescens).

PubMed

Sterck, Frank J; Zweifel, Roman; Sass-Klaassen, Ute; Chowdhury, Qumruzzaman

2008-04-01

Leaf specific conductivity (LSC; the ratio of stem conductivity (K(P)) to leaf area (A(L))), a measure of the hydraulic capacity of the stem to supply leaves with water, varies with soil water content. Empirical evidence for LSC responses to drought is ambiguous, because previously published results were subject to many confounding factors. We tested how LSC of similar-sized trees of the same population, under similar climatic conditions, responds to persistently wet or dry soil. Scots pine (Pinus sylvestris L.) and pubescent oak (Quercus pubescens Willd.) trees were compared between a dry site and a wet site in the Valais, an inner alpine valley in Switzerland. Soil water strongly influenced A(L) and K(P) and the plant components affecting K(P), such as conduit radius, conduit density and functional sapwood area. Trees at the dry site had lower LSC than trees with the same stem diameter at the wet site. Low LSC in trees at the dry site was associated with a smaller functional sapwood area and narrower conduits, resulting in a stronger reduction in K(P) than in A(L). These observations support the hypothesis that trees maintain a homeostatic water pressure gradient. An alternative hypothesis is that relatively high investments in leaves compared with sapwood contribute to carbon gain over an entire season by enabling rapid whole-plant photosynthesis during periods of high water availability (e.g., in spring, after rain events and during morning hours when leaf-to-air vapor pressure deficit is small). Dynamic data and a hydraulic plant growth model are needed to test how investments in leaves versus sapwood and roots contribute to transpiration and to maximizing carbon gain throughout entire growth seasons.

Using laser scanning cytometry to measure PPAR-mediated peroxisome proliferation and beta oxidation.

PubMed

Pruimboom-Brees, Ingrid M; Brees, Dominique J J E; Shen, Amy C; Keener, Mary; Francone, Omar; Amacher, David E; Loy, James K; Kerlin, Roy L

2005-01-01

Laser scanning cytometry (LSC) is a new technology that combines the properties and advantages of flow cytometry (FC) and immunohistochemistry (IHC), thus providing qualitative and quantitative information on protein expression with the additional perspective provided by cell and tissue localization. Formalin-fixed, paraffin embedded liver sections from rats exposed to a Peroxisome Proliferator Activated Receptor (PPAR) agonist were stained with antibodies against peroxisomal targeting signal-1 (PTS-1) (a highly conserved tripeptide contained within all peroxisomal enzymes), Acyl CoA oxidase (AOX) (the rate limiting enzyme of peroxisomal beta oxidation), and catalase (an inducible peroxisomal antioxidant enzyme) to evaluate peroxisomal beta oxidation, oxidative stress, and peroxisome proliferation. The LSC showed increased AOX, catalase, and PTS-1 expression in centrilobular hepatocytes that correlated favorably with the microscopic observation of centrilobular hepatocellular hypertrophy and with the palmitoyl CoA biochemical assay for peroxisomal beta oxidation, and provided additional morphologic information about peroxisome proliferation and tissue patterns of activation. Therefore, the LSC provides qualitative and quantitative evaluation of peroxisome activity with similar sensitivity but higher throughput than the traditional biochemical methods. The additional benefits of the LSC include the direct correlation between histopathologic observations and peroxisomal alterations and the potential utilization of archived formalin-fixed tissues from a variety of organs and species.

Use of Emerging Grid Computing Technologies for the Analysis of LIGO Data

NASA Astrophysics Data System (ADS)

Koranda, Scott

2004-03-01

The LIGO Scientific Collaboration (LSC) today faces the challenge of enabling analysis of terabytes of LIGO data by hundreds of scientists from institutions all around the world. To meet this challenge the LSC is developing tools, infrastructure, applications, and expertise leveraging Grid Computing technologies available today, and making available to LSC scientists compute resources at sites across the United States and Europe. We use digital credentials for strong and secure authentication and authorization to compute resources and data. Building on top of products from the Globus project for high-speed data transfer and information discovery we have created the Lightweight Data Replicator (LDR) to securely and robustly replicate data to resource sites. We have deployed at our computing sites the Virtual Data Toolkit (VDT) Server and Client packages, developed in collaboration with our partners in the GriPhyN and iVDGL projects, providing uniform access to distributed resources for users and their applications. Taken together these Grid Computing technologies and infrastructure have formed the LSC DataGrid--a coherent and uniform environment across two continents for the analysis of gravitational-wave detector data. Much work, however, remains in order to scale current analyses and recent lessons learned need to be integrated into the next generation of Grid middleware.

Laser scanning cytometry for automation of the micronucleus assay

PubMed Central

Darzynkiewicz, Zbigniew; Smolewski, Piotr; Holden, Elena; Luther, Ed; Henriksen, Mel; François, Maxime; Leifert, Wayne; Fenech, Michael

2011-01-01

Laser scanning cytometry (LSC) provides a novel approach for automated scoring of micronuclei (MN) in different types of mammalian cells, serving as a biomarker of genotoxicity and mutagenicity. In this review, we discuss the advances to date in measuring MN in cell lines, buccal cells and erythrocytes, describe the advantages and outline potential challenges of this distinctive approach of analysis of nuclear anomalies. The use of multiple laser wavelengths in LSC and the high dynamic range of fluorescence and absorption detection allow simultaneous measurement of multiple cellular and nuclear features such as cytoplasmic area, nuclear area, DNA content and density of nuclei and MN, protein content and density of cytoplasm as well as other features using molecular probes. This high-content analysis approach allows the cells of interest to be identified (e.g. binucleated cells in cytokinesis-blocked cultures) and MN scored specifically in them. MN assays in cell lines (e.g. the CHO cell MN assay) using LSC are increasingly used in routine toxicology screening. More high-content MN assays and the expansion of MN analysis by LSC to other models (i.e. exfoliated cells, dermal cell models, etc.) hold great promise for robust and exciting developments in MN assay automation as a high-content high-throughput analysis procedure. PMID:21164197

Laser Scanning Cytometry: Principles and Applications—An Update

PubMed Central

Pozarowski, Piotr; Holden, Elena; Darzynkiewicz, Zbigniew

2012-01-01

Laser scanning cytometer (LSC) is the microscope-based cytofluorometer that offers a plethora of unique analytical capabilities, not provided by flow cytometry (FCM). This review describes attributes of LSC and covers its numerous applications derived from plentitude of the parameters that can be measured. Among many LSC applications the following are emphasized: (a) assessment of chromatin condensation to identify mitotic, apoptotic cells, or senescent cells; (b) detection of nuclear or mitochondrial translocation of critical factors such as NF-κB, p53, or Bax; (c) semi-automatic scoring of micronuclei in mutagenicity assays; (d) analysis of fluorescence in situ hybridization (FISH) and use of the FISH analysis attribute to measure other punctuate fluorescence patterns such as γH2AX foci or receptor clustering; (e) enumeration and morphometry of nucleoli and other cell organelles; (f) analysis of progeny of individual cells in clonogenicity assay; (g) cell immunophenotyping; (h) imaging, visual examination, or sequential analysis using different probes of the same cells upon their relocation; (i) in situ enzyme kinetics, drug uptake, and other time-resolved processes; (j) analysis of tissue section architecture using fluorescent and chromogenic probes; (k) application for hypocellular samples (needle aspirate, spinal fluid, etc.); and (l) other clinical applications. Advantages and limitations of LSC are discussed and compared with FCM. PMID:23027005

Simultaneous determination of specific alpha and beta emitters by LSC-PLS in water samples.

PubMed

Fons-Castells, J; Tent-Petrus, J; Llauradó, M

2017-01-01

Liquid scintillation counting (LSC) is a commonly used technique for the determination of alpha and beta emitters. However, LSC has poor resolution and the continuous spectra for beta emitters hinder the simultaneous determination of several alpha and beta emitters from the same spectrum. In this paper, the feasibility of multivariate calibration by partial least squares (PLS) models for the determination of several alpha ( nat U, 241 Am and 226 Ra) and beta emitters ( 40 K, 60 Co, 90 Sr/ 90 Y, 134 Cs and 137 Cs) in water samples is reported. A set of alpha and beta spectra from radionuclide calibration standards were used to construct three PLS models. Experimentally mixed radionuclides and intercomparision materials were used to validate the models. The results had a maximum relative bias of 25% when all the radionuclides in the sample were included in the calibration set; otherwise the relative bias was over 100% for some radionuclides. The results obtained show that LSC-PLS is a useful approach for the simultaneous determination of alpha and beta emitters in multi-radionuclide samples. However, to obtain useful results, it is important to include all the radionuclides expected in the studied scenario in the calibration set. Copyright © 2016 Elsevier Ltd. All rights reserved.

Lighting system combining daylight concentrators and an artificial source

DOEpatents

Bornstein, Jonathan G.; Friedman, Peter S.

1985-01-01

A combined lighting system for a building interior includes a stack of luminescent solar concentrators (LSC), an optical conduit made of preferably optical fibers for transmitting daylight from the LSC stack, a collimating lens set at an angle, a fixture for receiving the daylight at one end and for distributing the daylight as illumination inside the building, an artificial light source at the other end of the fixture for directing artifical light into the fixture for distribution as illumination inside the building, an automatic dimmer/brightener for the artificial light source, and a daylight sensor positioned near to the LSC stack for controlling the automatic dimmer/brightener in response to the daylight sensed. The system also has a reflector positioned behind the artificial light source and a fan for exhausting heated air out of the fixture during summer and for forcing heated air into the fixture for passage into the building interior during winter.

13th ERS Lung Science Conference. The most important take home messages: News from the Underground.

PubMed

Bikov, Andras; Boots, Agnes; Bjerg, Anders; Jacinto, Tiago; Olland, Anne; Skoczyński, Szymon

2015-06-01

The 13th ERS Lung Science Conference (LSC) was organised to bring academics together from all over the world to present and discuss the latest developments regarding lung infection and immunity. The conference took place in breathtaking Estoril, Portugal; however, it wasn't the beautiful surroundings that were our main motivation to attend, but instead the scientific merit of the conference and the chance to create new scientific collaborations. The scientific programme [1] was packed with the most up-to-date content in the field of lung infection and immunity and included some of the top researchers within this exciting area. Moreover, the convenient size of the LSC offered the opportunity to renew and intensify friendships and collaborations. In particular, for researchers at the start of their career, this is a great feature and we therefore warmly recommend the LSC to ERS Juniors Members!

Spatial coherence effect on layer thickness determination in narrowband full-field optical coherence tomography.

PubMed

Safrani, Avner; Abdulhalim, Ibrahim

2011-06-20

Longitudinal spatial coherence (LSC) is determined by the spatial frequency content of an optical beam. The use of lenses with a high numerical aperture (NA) in full-field optical coherence tomography and a narrowband light source makes the LSC length much shorter than the temporal coherence length, hence suggesting that high-resolution 3D images of biological and multilayered samples can be obtained based on the low LSC. A simplified model is derived, supported by experimental results, which describes the expected interference output signal of multilayered samples when high-NA lenses are used together with a narrowband light source. An expression for the correction factor for the layer thickness determination is found valid for high-NA objectives. Additionally, the method was applied to a strongly scattering layer, demonstrating the potential of this method for high-resolution imaging of scattering media.

Analytical study of laser-supported combustion waves in hydrogen

NASA Technical Reports Server (NTRS)

Kemp, N. H.; Root, R. G.

1978-01-01

Laser supported combustion (LSC) waves are an important ingredient in the fluid mechanics of CW laser propulsion using a hydrogen propellant and 10.6 micron lasers. Therefore, a computer model has been constructed to solve the one-dimensional energy equation with constant pressure and area. Physical processes considered include convection, conduction, absorption of laser energy, radiation energy loss, and accurate properties of equilibrium hydrogen. Calculations for 1, 3, 10 and 30 atm were made for intensities of 10 to the 4th to 10 to the 6th W/sq cm, which gave temperature profiles, wave speed, etc. To pursue the propulsion application, a second computer model was developed to describe the acceleration of the gas emerging from the LSC wave into a variable-pressure, converging streamtube, still including all the above-mentioned physical processes. The results show very high temperatures in LSC waves which absorb all the laser energy, and high radiative losses.

Thermal convection of liquid sodium in inclined cylinders

NASA Astrophysics Data System (ADS)

Khalilov, Ruslan; Kolesnichenko, Ilya; Pavlinov, Alexander; Mamykin, Andrey; Shestakov, Alexander; Frick, Peter

2018-04-01

The effect of inclination on the low Prandtl number turbulent convection in a cylinder of unit aspect ratio was studied experimentally. The working fluid was sodium (Prandtl number Pr =0.0094 ), the measurements were performed for a fixed Rayleigh number Ra =(1.47 ±0.03 ) ×107 , and the inclination angle varied from β =0∘ (the Rayleigh-Bénard convection, the temperature gradient is vertical) up to β =90∘ (the applied temperature gradient is horizontal) with a step Δ β =10∘ . The effective axial heat flux characterized by the Nusselt number is minimal at β =0∘ and demonstrates a smooth growth with the increase of the cylinder inclination, reaching a maximum at angle β ≈70∘ and decreasing with a further increase of β . The maximal value of the normalized Nusselt number Nu (β )/Nu (0 ) was 1.21. In general, the dependence of Nu (β ) in a cylinder with unit aspect ratio is similar to what was observed in sodium convection in inclined long cylinders but is much weaker. The structure of the flow undergoes a significant transformation with inclination. Under moderate inclination (β ≲30∘ ), the fluctuations are strong and are provided by regular oscillations of large-scale circulation (LSC) and by turbulence. Under large inclination (β >60∘ ), the LSC is regular and the turbulence is weak, while in transient regimes (30∘<β <60∘ ), the LSC fluctuations are weak and the turbulence decreases with inclination. The maximum Nusselt number corresponds to the border of transient and large inclinations. We find the first evidence of strong LSC fluctuations in low Prandtl number convective flow under moderate inclination. The rms azimuthal fluctuations of LSC, about 27∘ at β =0∘ , decrease almost linearly up to β =30∘ , where they are about 9∘. The angular fluctuations in the vicinity of the end faces are much stronger (about 37∘ at β =0∘ ) and weakly decrease up to β =20∘ . The strong anticorrelation of the fluctuations in two halves of the cylinder indicates the torsional character of LSC fluctuations. At β =30∘ , the intensity of the oscillations at the periphery of the cylinder falls sharply to the level of oscillations in the central plane and the anticorrelation disappears; the torsional fluctuations vanish.

MEASUREMENTS OF AIRBORNE CONCENTRATIONS OF RADON AND THORON DECAY PRODUCTS.

PubMed

Chalupnik, S; Skubacz, K; Urban, P; Wysocka, M

2017-11-01

Liquid scintillation counting (LSC) is a measuring technique, broadly applied in environmental monitoring of radionuclides. One of the possible applications of LSC is the measurement of radon and thoron decay products. But this method is suitable only for grab sampling. For long-term measurements a different technique can be applied-monitors of potential alpha energy concentration (PAEC) with thermoluminescent detectors (TLD). In these devices, called Alfa-2000 sampling probe, TL detectors (CaSO4:Dy) are applied for alpha particles counting. Three independent heads are placed over the membrane filter in a dust sampler's microcyclone. Such solution enables simultaneous measurements of PAEC and dust content. Moreover, the information which is stored in TLD chips is the energy of alpha particles, not the number of counted particles. Therefore, the readout of TL detector shows directly potential alpha energy, with no dependence on equilibrium factor, etc. This technique, which had been used only for radon decay products measurements, was modified by author to allow simultaneous measurements of radon and thoron PAEC. The LSC method can be used for calibration of portable radon decay products monitors. The LSC method has the advantage to be an absolute one, the TLD method to measure directly the (dose relevant) deposited energy. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Deregulated hedgehog pathway signaling is inhibited by the smoothened antagonist LDE225 (Sonidegib) in chronic phase chronic myeloid leukaemia

PubMed Central

Irvine, David A.; Zhang, Bin; Kinstrie, Ross; Tarafdar, Anuradha; Morrison, Heather; Campbell, Victoria L.; Moka, Hothri A.; Ho, Yinwei; Nixon, Colin; Manley, Paul W.; Wheadon, Helen; Goodlad, John R.; Holyoake, Tessa L.; Bhatia, Ravi; Copland, Mhairi

2016-01-01

Targeting the Hedgehog (Hh) pathway represents a potential leukaemia stem cell (LSC)-directed therapy which may compliment tyrosine kinase inhibitors (TKIs) to eradicate LSC in chronic phase (CP) chronic myeloid leukaemia (CML). We set out to elucidate the role of Hh signaling in CP-CML and determine if inhibition of Hh signaling, through inhibition of smoothened (SMO), was an effective strategy to target CP-CML LSC. Assessment of Hh pathway gene and protein expression demonstrated that the Hh pathway is activated in CD34+ CP-CML stem/progenitor cells. LDE225 (Sonidegib), a small molecule, clinically investigated SMO inhibitor, used alone and in combination with nilotinib, inhibited the Hh pathway in CD34+ CP-CML cells, reducing the number and self-renewal capacity of CML LSC in vitro. The combination had no effect on normal haemopoietic stem cells. When combined, LDE225 + nilotinib reduced CD34+ CP-CML cell engraftment in NSG mice and, upon administration to EGFP+ /SCLtTA/TRE-BCR-ABL mice, the combination enhanced survival with reduced leukaemia development in secondary transplant recipients. In conclusion, the Hh pathway is deregulated in CML stem and progenitor cells. We identify Hh pathway inhibition, in combination with nilotinib, as a potentially effective therapeutic strategy to improve responses in CP-CML by targeting both stem and progenitor cells. PMID:27157927

Optimizing luminescent solar concentrator design

DOE PAGES

Hernandez-Noyola, Hermilo; Potterveld, David H.; Holt, Roy J.; ...

2011-12-21

Luminescent Solar Concentrators (LSCs) use fluorescent materials and light guides to convert direct and diffuse sunlight into concentrated wavelength-shifted light that produces electrical power in small photovoltaic (PV) cells with the goal of significantly reducing the cost of solar energy utilization. In this paper we present an optimization analysis based on the implementation of a genetic algorithm (GA) subroutine to a numerical ray-tracing Monte Carlo model of an LSC, SIMSOLAR-P. The initial use of the GA implementation in SIMSOLAR-P is to find the optimal parameters of a hypothetical ‘‘perfect luminescent material’’ that obeys the Kennard Stepanov (K-S) thermodynamic relationship betweenmore » emission and absorption. The optimization balances the efficiency losses in the wavelength shift and PV conversion with the efficiency losses due to re-scattering of light out of the collector. The theoretical limits of efficiency are provided for one, two and three layer configurations; the results show that a single layer configuration is far from optimal and adding a second layer in the LSC with wavelength shifted material in the near infrared region significantly increases the power output, while the gain in power by adding a third layer is relatively small. Here, the results of this study provide a theoretical upper limit to the performance of an LSC and give guidance for the properties required for luminescent materials, such as quantum nanocrystals, to operate efficiently in planar LSC configurations« less

Boltzmann-conserving classical dynamics in quantum time-correlation functions: "Matsubara dynamics".

PubMed

Hele, Timothy J H; Willatt, Michael J; Muolo, Andrea; Althorpe, Stuart C

2015-04-07

We show that a single change in the derivation of the linearized semiclassical-initial value representation (LSC-IVR or "classical Wigner approximation") results in a classical dynamics which conserves the quantum Boltzmann distribution. We rederive the (standard) LSC-IVR approach by writing the (exact) quantum time-correlation function in terms of the normal modes of a free ring-polymer (i.e., a discrete imaginary-time Feynman path), taking the limit that the number of polymer beads N → ∞, such that the lowest normal-mode frequencies take their "Matsubara" values. The change we propose is to truncate the quantum Liouvillian, not explicitly in powers of ħ(2) at ħ(0) (which gives back the standard LSC-IVR approximation), but in the normal-mode derivatives corresponding to the lowest Matsubara frequencies. The resulting "Matsubara" dynamics is inherently classical (since all terms O(ħ(2)) disappear from the Matsubara Liouvillian in the limit N → ∞) and conserves the quantum Boltzmann distribution because the Matsubara Hamiltonian is symmetric with respect to imaginary-time translation. Numerical tests show that the Matsubara approximation to the quantum time-correlation function converges with respect to the number of modes and gives better agreement than LSC-IVR with the exact quantum result. Matsubara dynamics is too computationally expensive to be applied to complex systems, but its further approximation may lead to practical methods.

Alterations in brain Protein Kinase A activity and reversal of morphine tolerance by two fragments of native Protein Kinase A inhibitor peptide (PKI).

PubMed

Dalton, George D; Smith, Forrest L; Smith, Paul A; Dewey, William L

2005-04-01

Two peptide fragments of native Protein Kinase A inhibitor (PKI), PKI-(6-22)-amide and PKI-(Myr-14-22)-amide, significantly reversed low-level morphine antinociceptive tolerance in mice. The inhibition of Protein Kinase A (PKA) activity by both peptide fragments was then measured in specific brain regions (thalamus, periaqueductal gray (PAG), and medulla) and in lumbar spinal cord (LSC), which in previous studies have been shown to play a role in morphine-induced analgesia. In drug naive animals, cytosolic PKA activity was greater than particulate PKA activity in each region, while cytosolic and particulate PKA activities were greater in thalamus and PAG compared to medulla and LSC. The addition of both peptides to homogenates from each region completely abolished cytosolic and particulate PKA activities in vitro. Following injection into the lateral ventricle of the brain of drug naive mice and morphine-tolerant mice, both peptides inhibited PKA activity in the cytosolic, but not the particulate fraction of LSC. In addition, cytosolic and particulate PKA activities were inhibited by both peptides in thalamus. These results demonstrate that the inhibition of PKA reverses morphine tolerance. Moreover, the inhibition of PKA activity in specific brain regions and LSC from morphine-tolerant mice by PKI analogs administered i.c.v. is evidence that PKA plays a role in morphine tolerance.

Medicare and Medicaid Programs; Fire Safety Requirements for Certain Health Care Facilities. Final rule.

PubMed

2016-05-04

This final rule will amend the fire safety standards for Medicare and Medicaid participating hospitals, critical access hospitals (CAHs), long-term care facilities, intermediate care facilities for individuals with intellectual disabilities (ICF-IID), ambulatory surgery centers (ASCs), hospices which provide inpatient services, religious non-medical health care institutions (RNHCIs), and programs of all-inclusive care for the elderly (PACE) facilities. Further, this final rule will adopt the 2012 edition of the Life Safety Code (LSC) and eliminate references in our regulations to all earlier editions of the Life Safety Code. It will also adopt the 2012 edition of the Health Care Facilities Code, with some exceptions.

A comparison of chloroplast genome sequences in Aconitum (Ranunculaceae): a traditional herbal medicinal genus

PubMed Central

Yao, Gang

2017-01-01

The herbal medicinal genus Aconitum L., belonging to the Ranunculaceae family, represents the earliest diverging lineage within the eudicots. It currently comprises of two subgenera, A. subgenus Lycoctonum and A. subg. Aconitum. The complete chloroplast (cp) genome sequences were characterized in three species: A. angustius, A. finetianum, and A. sinomontanum in subg. Lycoctonum and compared to other Aconitum species to clarify their phylogenetic relationship and provide molecular information for utilization of Aconitum species particularly in Eastern Asia. The length of the chloroplast genome sequences were 156,109 bp in A. angustius, 155,625 bp in A. finetianum and 157,215 bp in A. sinomontanum, with each species possessing 126 genes with 84 protein coding genes (PCGs). While genomic rearrangements were absent, structural variation was detected in the LSC/IR/SSC boundaries. Five pseudogenes were identified, among which Ψrps19 and Ψycf1 were in the LSC/IR/SSC boundaries, Ψrps16 and ΨinfA in the LSC region, and Ψycf15 in the IRb region. The nucleotide variability (Pi) of Aconitum was estimated to be 0.00549, with comparably higher variations in the LSC and SSC than the IR regions. Eight intergenic regions were revealed to be highly variable and a total of 58–62 simple sequence repeats (SSRs) were detected in all three species. More than 80% of SSRs were present in the LSC region. Altogether, 64.41% and 46.81% of SSRs are mononucleotides in subg. Lycoctonum and subg. Aconitum, respectively, while a higher percentage of di-, tri-, tetra-, and penta- SSRs were present in subg. Aconitum. Most species of subg. Aconitum in Eastern Asia were first used for phylogenetic analyses. The availability of the complete cp genome sequences of these species in subg. Lycoctonum will benefit future phylogenetic analyses and aid in germplasm utilization in Aconitum species. PMID:29134154

A comparison of chloroplast genome sequences in Aconitum (Ranunculaceae): a traditional herbal medicinal genus.

PubMed

Kong, Hanghui; Liu, Wanzhen; Yao, Gang; Gong, Wei

2017-01-01

The herbal medicinal genus Aconitum L., belonging to the Ranunculaceae family, represents the earliest diverging lineage within the eudicots. It currently comprises of two subgenera, A . subgenus Lycoctonum and A . subg. Aconitum . The complete chloroplast (cp) genome sequences were characterized in three species: A. angustius , A. finetianum , and A. sinomontanum in subg. Lycoctonum and compared to other Aconitum species to clarify their phylogenetic relationship and provide molecular information for utilization of Aconitum species particularly in Eastern Asia. The length of the chloroplast genome sequences were 156,109 bp in A. angustius , 155,625 bp in A. finetianum and 157,215 bp in A. sinomontanum , with each species possessing 126 genes with 84 protein coding genes (PCGs). While genomic rearrangements were absent, structural variation was detected in the LSC/IR/SSC boundaries. Five pseudogenes were identified, among which Ψ rps 19 and Ψ ycf 1 were in the LSC/IR/SSC boundaries, Ψ rps 16 and Ψ inf A in the LSC region, and Ψ ycf 15 in the IRb region. The nucleotide variability ( Pi ) of Aconitum was estimated to be 0.00549, with comparably higher variations in the LSC and SSC than the IR regions. Eight intergenic regions were revealed to be highly variable and a total of 58-62 simple sequence repeats (SSRs) were detected in all three species. More than 80% of SSRs were present in the LSC region. Altogether, 64.41% and 46.81% of SSRs are mononucleotides in subg. Lycoctonum and subg. Aconitum , respectively, while a higher percentage of di-, tri-, tetra-, and penta- SSRs were present in subg. Aconitum . Most species of subg. Aconitum in Eastern Asia were first used for phylogenetic analyses. The availability of the complete cp genome sequences of these species in subg. Lycoctonum will benefit future phylogenetic analyses and aid in germplasm utilization in Aconitum species.

Sol-gel derived (La 0.8M 0.2)CrO 3 (M dbnd Ca, Sr) coating layer on stainless-steel substrate for use as a separator in intermediate-temperature solid oxide fuel cell

NASA Astrophysics Data System (ADS)

A Lee, E.; Lee, S.; Hwang, H. J.; Moon, J.-W.

A ceramic coating technique is applied to reduce the voltage drop caused by oxidation of the metallic separator (SUS444) in intermediate-temperature (IT) solid oxide fuel cell (SOFCs) systems. Precursor solutions for (La, Ca)CrO 3 (LCC) and (La, Sr)CrO 3 (LSC) coatings are prepared by adding nitric acid and ethylene glycol into an aqueous solution of lanthanum, strontium (or calcium) and chromium nitrates. Dried LCC and LSC gel films are heat-treated at 400-800 °C after dip-coating on the SUS444 substrate. XRD and Fourier-transform infrared (FT-IR) analysis is used to examine the crystallization behaviour and chemical structure of the precursor solution. The oxidation behaviour of the coated SUS444 substrate is compared with an uncoated SUS444 substrate. The oxidation of the SUS444 is inhibited by the LCC and LSC thin film layers.

The NEW detector: construction, commissioning and first results

NASA Astrophysics Data System (ADS)

Nebot-Guinot, M.; NEXT Collaboration

2017-09-01

NEXT (Neutrino Experiment with a Xenon TPC) is a neutrinoless double-beta (ββ0ν) decay experiment at the Canfranc Underground Laboratory (LSC). It seeks to detect the ββ0ν decay of Xe-136 using a high pressure xenon gas TPC with electroluminescent (EL) amplification. The NEXT-White (NEW) detector, with an active xenon mass of about 10 kg at 15 bar, is the first NEXT prototype installed at LSC. It implements the NEXT detector concept tested in smaller prototypes using the same radiopure sensors and materials that will be used in the future NEXT-100, serving as a benchmark for technical solutions as well as for the signal selection and background rejection algorithms. NEW is currently under commissioning at the LSC. In this poster proceedings we describe the technical solutions adopted for NEW construction, the lessons learned from the commissioning phase, and the first results on energy calibration and energy resolution obtained with low-energy radioactive source data.

Ignition-and-Growth Modeling of NASA Standard Detonator and a Linear Shaped Charge

NASA Technical Reports Server (NTRS)

Oguz, Sirri

2010-01-01

The main objective of this study is to quantitatively investigate the ignition and shock sensitivity of NASA Standard Detonator (NSD) and the shock wave propagation of a linear shaped charge (LSC) after being shocked by NSD flyer plate. This combined explosive train was modeled as a coupled Arbitrary Lagrangian-Eulerian (ALE) model with LS-DYNA hydro code. An ignition-and-growth (I&G) reactive model based on unreacted and reacted Jones-Wilkins-Lee (JWL) equations of state was used to simulate the shock initiation. Various NSD-to-LSC stand-off distances were analyzed to calculate the shock initiation (or failure to initiate) and detonation wave propagation along the shaped charge. Simulation results were verified by experimental data which included VISAR tests for NSD flyer plate velocity measurement and an aluminum target severance test for LSC performance verification. Parameters used for the analysis were obtained from various published data or by using CHEETAH thermo-chemical code.

Tandem luminescent solar concentrators based on engineered quantum dots

NASA Astrophysics Data System (ADS)

Wu, Kaifeng; Li, Hongbo; Klimov, Victor I.

2018-02-01

Luminescent solar concentrators (LSCs) can serve as large-area sunlight collectors for terrestrial and space-based photovoltaics. Due to their high emission efficiencies and readily tunable emission and absorption spectra, colloidal quantum dots have emerged as a new and promising type of LSC fluorophore. Spectral tunability of the quantum dots also facilitates the realization of stacked multilayered LSCs, where enhanced performance is obtained through spectral splitting of incident sunlight, as in multijunction photovoltaics. Here, we demonstrate a large-area (>230 cm2) tandem LSC based on two types of nearly reabsorption-free quantum dots spectrally tuned for optimal solar-spectrum splitting. This prototype device exhibits a high optical quantum efficiency of 6.4% for sunlight illumination and solar-to-electrical power conversion efficiency of 3.1%. The efficiency gains due to the tandem architecture over single-layer devices quickly increase with increasing LSC size and can reach more than 100% in structures with window sizes of more than 2,500 cm2.

Analytical study of laser supported combustion waves in hydrogen

NASA Technical Reports Server (NTRS)

Kemp, N. H.; Root, R. G.

1977-01-01

A one-dimensional energy equation, with constant pressure and area, was used to model the LSC wave. This equation balances convection, conduction, laser energy absorption, radiation energy loss and radiation energy transport. Solutions of this energy equation were obtained to give profiles of temperature and other properties, as well as the relation between laser intensity and mass flux through the wave. The flow through the LSC wave was then conducted through a variable pressure, variable area streamtube to accelerate it to high speed, with the propulsion application in mind. A numerical method for coupling the LSC wave model to the streamtube flow was developed, and a sample calculation was performed. The result shows that 42% of the laser power has been radiated away by the time the gas reaches the throat. It was concluded that in the radially confined flows of interest for propulsion applications, transverse velocities would be less important than in the unconfined flows where air experiments have been conducted.

Nonimaging optics in luminescent solar concentration.

PubMed

Markman, B D; Ranade, R R; Giebink, N C

2012-09-10

Light trapped within luminescent solar concentrators (LSCs) is naturally limited in angular extent by the total internal reflection critical angle, θcrit, and hence the principles of nonimaging optics can be leveraged to increase LSC concentration ratio by appropriately reshaping the edges. Here, we use rigorous ray-tracing simulations to explore the potential of this concept for realistic LSCs with compound parabolic concentrator (CPC)-tapered edges and show that, when applied to a single edge, the concentration ratio is increased by 23% while maintaining >90% of the original LSC optical efficiency. Importantly, we find that CPC-tapering all of the edges enables a significantly greater intensity enhancement up to 35% at >90% of the original optical efficiency, effectively enabling two-dimensional concentration through a cooperative, ray-recycling effect in which rays rejected by one CPC are accepted by another. These results open up a significant opportunity to improve LSC performance at virtually no added manufacturing cost by incorporating nonimaging optics into their design.

Characteristics of alpha-glucosidase production from recombinant Aspergillus oryzae by membrane-surface liquid culture in comparison with various cultivation methods.

PubMed

Morita, Masakazu; Shimamura, Hiroko; Ishida, Natsuko; Imamura, Koreyoshi; Sakiyama, Takaharu; Nakanishi, Kazuhiro

2004-01-01

alpha-Glucosidase was produced using recombinant Aspergillus oryzae by membrane-surface liquid culture (MSLC), a method previously developed by the authors and the results compared with other methods, including shaking flask culture (SFC), agar-plate culture (APC), culture on urethane sponge supports (USC), and liquid surface culture (LSC) to determine possible reasons for the advantageous features of MSLC. When yeast extract was used as a nitrogen source, the amount of enzyme produced by MSLC was 5 or more times higher than those for SFC and LSC, but similar to that using APC. Enzyme production in USC was slightly lower than in MSLC and APC. Cell growth was similar irrespective of the cultivation method used. When NaNO3, a typical inorganic nitrogen source was used, enzyme production in all the cultures was lower than that using yeast extract. However, even using NaNO3, the amount of the enzyme produced by MSLC was 8 to 20 times higher than those by SFC, APC, USC, and LSC. Although cell growth using NaNO3 was similar to that for yeast extract in MSLC, it was markedly decreased in SFC, APC, and LSC. The reason for the difference in enzyme productivity for various cultivation methods using yeast extract and NaNO3 as a nitrogen source is discussed, on the basis of the experimental findings. The role of the oxygen transfer effect and gene expression levels in enzyme production were also examined.

Hierarchical Mesoporous/Macroporous Perovskite La0.5Sr0.5CoO3-x Nanotubes: A Bifunctional Catalyst with Enhanced Activity and Cycle Stability for Rechargeable Lithium Oxygen Batteries.

PubMed

Liu, Guoxue; Chen, Hongbin; Xia, Lu; Wang, Suqing; Ding, Liang-Xin; Li, Dongdong; Xiao, Kang; Dai, Sheng; Wang, Haihui

2015-10-14

Perovskites show excellent specific catalytic activity toward both oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) in alkaline solutions; however, small surface areas of the perovskites synthesized by traditional sol-gel methods lead to low utilization of catalytic sites, which gives rise to poor Li-O2 batteries performance and restricts their application. Herein, a hierarchical mesporous/macroporous perovskite La0.5Sr0.5CoO3-x (HPN-LSC) nanotube is developed to promote its application in Li-O2 batteries. The HPN-LSC nanotubes were synthesized via electrospinning technique followed by postannealing. The as-prepared HPN-LSC catalyst exhibits outstanding intrinsic ORR and OER catalytic activity. The HPN-LSC/KB electrode displays excellent performance toward both discharge and charge processes for Li-O2 batteries, which enhances the reversibility, the round-trip efficiency, and the capacity of resultant batteries. The synergy of high catalytic activity and hierarchical mesoporous/macroporous nanotubular structure results in the Li-O2 batteries with good rate capability and excellent cycle stability of sustaining 50 cycles at a current density of 0.1 mA cm(-2) with an upper-limit capacity of 500 mAh g(-1). The results will benefit for the future development of high-performance Li-O2 batteries using hierarchical mesoporous/macroporous nanostructured perovskite-type catalysts.

Effects of sodium chloride on selected parameters in cats.

PubMed

Kirk, Claudia A; Jewell, Dennis E; Lowry, Stephen R

2006-01-01

This study used 36 cats with varying renal insufficiency and physiologic status to evaluate the effect of a food high in sodium chloride (HSC) compared with a low sodium chloride (LSC) food on selected blood parameters and blood pressure. Cats eating the HSC food had an increase in serum creatinine, urea nitrogen, and phosphorus compared with cats eating the LSC food. Also, cats eating the HSC food had increased fractional excretion of calcium and increased fractional shortening during cardiac contraction. There was no effect of food on systolic, diastolic, or mean arterial pressure.

Analysis of fuel using the Direct LSC method determination of bio-originated fuel in the presence of quenching

DOE PAGES

Doll, Charles G.; Wright, Cherylyn W.; Morley, Shannon M.; ...

2017-02-01

In this paper, a modified version of the Direct LSC method to correct for quenching effect was investigated for the determination of bio-originated fuel content in fuel samples produced from multiple biological starting materials. The modified method was found to be accurate in determining the percent bio-originated fuel to within 5% of the actual value for samples with quenching effects ≤43%. Finally, analysis of highly quenched samples was possible when diluted with the exception of one sample with a 100% quenching effect.

Analysis of fuel using the Direct LSC method determination of bio-originated fuel in the presence of quenching

DOE Office of Scientific and Technical Information (OSTI.GOV)

Doll, Charles G.; Wright, Cherylyn W.; Morley, Shannon M.

A modified version of the Direct LSC method to correct for quenching effect was investigated for the determination of bio-originated fuel content in fuel samples produced from multiple biological starting materials. The modified method was found to be accurate in determining the percent bio-originated fuel to within 5% of the actual value for samples with quenching effects ≤43%. Analysis of highly quenched samples was possible when diluted with the exception of one sample with a 100% quenching effect.

Analysis of fuel using the Direct LSC method determination of bio-originated fuel in the presence of quenching

DOE Office of Scientific and Technical Information (OSTI.GOV)

Doll, Charles G.; Wright, Cherylyn W.; Morley, Shannon M.

In this paper, a modified version of the Direct LSC method to correct for quenching effect was investigated for the determination of bio-originated fuel content in fuel samples produced from multiple biological starting materials. The modified method was found to be accurate in determining the percent bio-originated fuel to within 5% of the actual value for samples with quenching effects ≤43%. Finally, analysis of highly quenched samples was possible when diluted with the exception of one sample with a 100% quenching effect.

Characterization of Retinitis Pigmentosa Using Fluorescence Lifetime Imaging Ophthalmoscopy (FLIO).

PubMed

Andersen, Karl M; Sauer, Lydia; Gensure, Rebekah H; Hammer, Martin; Bernstein, Paul S

2018-06-01

We investigated fundus autofluorescence (FAF) lifetimes in patients with retinitis pigmentosa (RP) using fluorescence lifetime imaging ophthalmoscopy (FLIO). A total of 33 patients (mean age, 40.0 ± 17.0 years) with RP and an age-matched healthy group were included. The Heidelberg FLIO was used to detect FAF decays in short (SSC; 498-560 nm) and long (LSC; 560-720 nm) spectral channels. We investigated a 30° retinal field and calculated the amplitude-weighted mean fluorescence lifetime (τ m ). Additionally, macular pigment measurements, macular optical coherence tomography (OCT) scans, fundus photographs, visual fields, and fluorescein angiograms were recorded. Genetic studies were performed on nearly all patients. In RP, FLIO shows a typical pattern of prolonged τ m in atrophic regions in the outer macula (SSC, 419 ± 195 ps; LSC, 401 ± 111 ps). Within the relatively preserved retina in the macular region, ring-shaped patterns were found, most distinctive in patients with autosomal dominant RP inheritance. Mean FAF lifetimes were shortened in rings in the LSC. Central areas remained relatively unaffected. FLIO uniquely presents a distinct and specific signature in eyes affected with RP. The ring patterns show variations that indicate genetically determined pathologic processes. Shortening of FAF lifetimes in the LSC may indicate disease progression, as was previously demonstrated for Stargardt disease. Therefore, FLIO might be able to indicate disease progression in RP as well. Hyperfluorescent FLIO rings with short FAF lifetimes may provide insight into the pathophysiologic disease status of RP-affected retinas potentially providing a more detailed assessment of disease progression.

Interdecadal modulation of the Atlantic Multi-decadal Oscillation (AMO) on southwest China's temperature over the past 250 years

NASA Astrophysics Data System (ADS)

Fang, Keyan; Guo, Zhengtang; Chen, Deliang; Wang, Lei; Dong, Zhipeng; Zhou, Feifei; Zhao, Yan; Li, Jinbao; Li, Yingjun; Cao, Xinguang

2018-05-01

The temperature gradient between southwestern China and Indian Ocean is one key driver of the Indian Summer Monsoon, suggesting the necessity to understand temperature variability in southwestern China. Contrary to the general warming experienced in most of China, a few regions in southwestern China have undergone a cooling trend since the 1950s. To place this cooling trend in a historical context, this study develops an Abies fabri tree-ring width chronology in the Sichuan Basin, the most populated region in southwest China. The chronology spans from 1590 to 2012, with its reliable portion from 1758 to 2012, by far the longest in the Sichuan Basin. To better extract regional climate signals encoded in tree rings with strong local disturbances, we incorporate climate signals of nearby tree-ring chronologies to generate a large-scale tree-ring chronology (LSC). The LSC shows higher correlations with temperature near the sampling site on Mount Emei and sea surface temperatures of the northern Atlantic Ocean than chronologies developed using traditional methods. The highest correlations between the LSC and temperature are found from current February to July in the Sichuan Basin for the period 1901-1950 (r = 0.70), with a sharp decrease afterwards. Interdecadal variations of the LSC match well with Atlantic Multi-decadal Oscillation reconstructions, except for the late nineteenth century and after 1980s. This study provides evidence that southwest China is a transitional region both affected by the interdecadal temperature variations of the northern Atlantic and Asian areas, although their influences weakened in recent possible due to enhanced human activities.

Radiographic techniques in the explosive component facility at Sandia National Labs.

NASA Astrophysics Data System (ADS)

Lanoue, John C.

1997-05-01

The Explosive Component Facility at Sandia National Laboratory is a state of the art facility for the design and testing of energetic materials and components. Two key elements of these capabilities are the flash x-ray machines. One is a six head, 150 KeV and the other is a six head, 300 KeV instrument. One of the more interesting uses of the 150 KeV system has been to study the action and reaction of a linear shaped charge (LSC) while submerged in water. The submerged samples were viewed from the top to capture the interaction of one piece of LSC with another piece nearby. Each LSC was covered by separate rubber coverings and affixed to a composite-plate. Three heads, delayed by a specified time, were used to capture the time sequence of events in stop action. Side views of the LSC were done with and without the rubber coverings to examine the dampening effects of the cover. An end-on perspective was also captured by x-ray using one head and several time delays. The debris scatter produced from a larger device has also been examined. The explosive used was a pellet form initiated by a detonator and a timing lead. The x-ray radiographs show the particles from this device as they expand outward. Three x-ray source tubes were used in a large horizontal array, apertured to expose individual pieces of film. Another x-ray source was placed overhead and simultaneously exposed a film under the object.

Laser Scanning Cytometry

PubMed Central

Pozarowski, Piotr; Holden, Elena; Darzynkiewicz, Zbigniew

2013-01-01

Summary The laser scanning cytometer (LSC) is the microscope-based cytofluorometer that offers a plethora of analytical capabilities. Multilaser-excited fluorescence emitted from individual cells is measured at several wavelength ranges, rapidly (up to 5000 cells/min), with high sensitivity and accuracy. The following applications of LSC are reviewed: (1) identification of cells that differ in degree of chromatin condensation (e.g., mitotic or apoptotic cells or lymphocytes vs granulocytes vs monocytes); (2) detection of translocation between cytoplasm vs nucleus or nucleoplasm vs nucleolus of regulatory molecules such as NF- κB, p53, or Bax; (3) semiautomatic scoring of micronuclei in mutagenicity assays; (4) analysis of fluorescence in situ hybridization; (5) enumeration and morphometry of nucleoli; (6) analysis of phenotype of progeny of individual cells in clonogenicity assay; (7) cell immunophenotyping; (8) visual examination, imaging, or sequential analysis of the cells measured earlier upon their relocation, using different probes; (9) in situ enzyme kinetics and other time-resolved processes; (10) analysis of tissue section architecture; (11) application for hypocellular samples (needle aspirate, spinal fluid, etc.); (12) other clinical applications. Advantages and limitations of LSC are discussed and compared with flow cytometry. PMID:16719355

Combustion Synthesis of Sm0.5Sr0.5CoO3-x and La0.6Sr0.4CoO3-x Nanopowders for Solid Oxide Fuel Cell Cathodes

NASA Technical Reports Server (NTRS)

Bansal, Narottam P.; Zhong, zhimin

2005-01-01

Nanopowders of Sm0.5Sr0.5CoO(3-x) (SSC) and La0.6Sr0.4CoO(3-x) (LSC) compositions, which are being investigated as cathode materials for intermediate temperature solid oxide fuel cells, were synthesized by a solution-combustion method using metal nitrates and glycine as fuel. Development of crystalline phases in the as-synthesized powders after heat treatments at various temperatures was monitored by x-ray diffraction. Perovskite phase in LSC formed more readily than in SSC. Single phase perovskites were obtained after heat treatment of the combustion synthesized LSC and SSC powders at 1000 and 1200 C, respectively. The as-synthesized powders had an average particle size of 12 nm as determined from x-ray line broadening analysis using the Scherrer equation. Average grain size of the powders increased with increase in calcination temperature. Morphological analysis of the powders calcined at various temperatures was done by scanning electron microscopy.

Performance of a laser microsatellite network with an optical preamplifier.

PubMed

Arnon, Shlomi

2005-04-01

Laser satellite communication (LSC) uses free space as a propagation medium for various applications, such as intersatellite communication or satellite networking. An LSC system includes a laser transmitter and an optical receiver. For communication to occur, the line of sight of the transmitter and the receiver must be aligned. However, mechanical vibration and electronic noise in the control system reduce alignment between the transmitter laser beam and the receiver field of view (FOV), which results in pointing errors. The outcome of pointing errors is fading of the received signal, which leads to impaired link performance. An LSC system is considered in which the optical preamplifier is incorporated into the receiver, and a bit error probability (BEP) model is derived that takes into account the statistics of the pointing error as well as the optical amplifier and communication system parameters. The model and the numerical calculation results indicate that random pointing errors of sigma(chi)2G > 0.05 penalize communication performance dramatically for all combinations of optical amplifier gains and noise figures that were calculated.

Removal of actinide elements from liquid scintillation cocktail wastes using liquid-liquid extraction and demulsification techniques

DOE Office of Scientific and Technical Information (OSTI.GOV)

Foltz, K.; Landsberger, S.; Srinivasan, B.

1994-12-31

A method for the separation of radionuclides with Z greater than 88, from lower-level radioactive wastes (liquid scintillation cocktail or LSC wastes), is described. The method is liquid-liquid extraction (LLX) and demulsification. The actinide elements are removed from the LSC wastes by extraction into an aqueous phase after the cocktail has been demulsified. The aqueous and organic phases are separated, then the wastes type remaining may be incinerated. Future experiments will be performed to study the effects of pH and temperature and to extend the study to wastes containing americium.

Analysis of fuel using the Direct LSC method determination of bio-originated fuel in the presence of quenching.

PubMed

Doll, Charles G; Wright, Cherylyn W; Morley, Shannon M; Wright, Bob W

2017-04-01

A modified version of the Direct LSC method to correct for quenching effect was investigated for the determination of bio-originated fuel content in fuel samples produced from multiple biological starting materials. The modified method was found to be accurate in determining the percent bio-originated fuel to within 5% of the actual value for samples with quenching effects ≤43%. Analysis of highly quenched samples was possible when diluted with the exception of one sample with a 100% quenching effect. Copyright © 2017. Published by Elsevier Ltd.

Chemopreventive Effects of Dietary Eicosapentaenoic Acid Supplementation in Experimental Myeloid Leukemia.

PubMed

Finch, Emily R; Kudva, Avinash K; Quickel, Michael D; Goodfield, Laura L; Kennett, Mary J; Whelan, Jay; Paulson, Robert F; Prabhu, K Sandeep

2015-10-01

Current therapies for treatment of myeloid leukemia do not eliminate leukemia stem cells (LSC), leading to disease relapse. In this study, we supplemented mice with eicosapentaenoic acid (EPA, C20:5), a polyunsaturated omega-3 fatty acid, at pharmacologic levels, to examine whether the endogenous metabolite, cyclopentenone prostaglandin delta-12 PGJ3 (Δ(12)-PGJ3), was effective in targeting LSCs in experimental leukemia. EPA supplementation for 8 weeks resulted in enhanced endogenous production of Δ(12)-PGJ3 that was blocked by indomethacin, a cyclooxygenase (COX) inhibitor. Using a murine model of chronic myelogenous leukemia (CML) induced by bone marrow transplantation of BCR-ABL-expressing hematopoietic stem cells, mice supplemented with EPA showed a decrease in the LSC population, and reduced splenomegaly and leukocytosis, when compared with mice on an oleic acid diet. Supplementation of CML mice carrying the T315I mutation (in BCR-ABL) with EPA resulted in a similar effect. Indomethacin blocked the EPA effect and increased the severity of BCR-ABL-induced CML and decreased apoptosis. Δ(12)-PGJ3 rescued indomethacin-treated BCR-ABL mice and decreased LSCs. Inhibition of hematopoietic-prostaglandin D synthase (H-PGDS) by HQL-79 in EPA-supplemented CML mice also blocked the effect of EPA. In addition, EPA supplementation was effective in a murine model of acute myeloid leukemia. EPA-supplemented mice exhibited a decrease in leukemia burden and a decrease in the LSC colony-forming unit (LSC-CFU). The decrease in LSCs was confirmed through serial transplantation assays in all disease models. The results support a chemopreventive role for EPA in myeloid leukemia, which is dependent on the ability to efficiently convert EPA to endogenous COX-derived prostanoids, including Δ(12)-PGJ3. ©2015 American Association for Cancer Research.

Targeting survival pathways in chronic myeloid leukaemia stem cells

PubMed Central

Sinclair, A; Latif, A L; Holyoake, T L

2013-01-01

Chronic myeloid leukaemia (CML) is a clonal myeloproliferative disorder characterized by the presence of a fusion oncogene BCR-ABL, which encodes a protein with constitutive TK activity. The implementation of tyrosine kinase inhibitors (TKIs) marked a major advance in CML therapy; however, there are problems with current treatment. For example, relapse occurs when these drugs are discontinued in the majority of patients who have achieved a complete molecular response on TKI and these agents are less effective in patients with mutations in the BCR-ABL kinase domain. Importantly, TKI can effectively target proliferating mature cells, but do not eradicate quiescent leukaemic stem cells (LSCs), therefore allowing disease persistence despite treatment. It is essential that alternative strategies are used to target the LSC population. BCR-ABL activation is responsible for the modulation of different signalling pathways, which allows the LSC fraction to evade cell death. Several pathways have been shown to be modulated by BCR-ABL, including PI3K/AKT/mTOR, JAK-STAT and autophagy signalling pathways. Targeting components of these survival pathways, alone or in combination with TKI, therefore represents an attractive potential therapeutic approach for targeting the LSC. However, many pathways are also active in normal stem cells. Therefore, potential targets must be validated to effectively eradicate CML stem cells while sparing normal counterparts. This review summarizes the main pathways modulated in CML stem cells, the recent developments and the use of novel drugs to target components in these pathways which may be used to target the LSC population. Linked Articles This article is part of a themed section on Emerging Therapeutic Aspects in Oncology. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2013.169.issue-8 PMID:23517124

The Medial Extra-Sellar Corridor to the Cavernous Sinus: Anatomic Description and Clinical Correlation.

PubMed

Theodosopoulos, Philip V; Cebula, Helene; Kurbanov, Almaz; Cabero, Arnau Benet; Osorio, Joseph A; Zimmer, Lee A; Froelich, Sebastien C; Keller, Jeffrey T

2016-12-01

The zenith of surgical interest in the cavernous sinus peaked in the 1980s, as evidenced by reports of 10 surgical triangles that could access the contents of the lateral sellar compartment (LSC). However, these transcranial approaches later became marginalized, first by radiosurgery's popularity and lower morbidity, and then by clinical potential of endoscopic corridors noted in several qualitative studies. Our anatomic study, taking a contemporary look at the medial extra-sellar corridor, gives a detailed qualitative-quantitative analysis for its use with increasingly popular endoscopic endonasal approaches to the cavernous sinus. In 20 cadaveric specimens, we re-examined the anatomic landmarks of the medial corridor into the LSC with qualitative descriptions and measurements. An illustrative case highlights a recurrent symptomatic pituitary adenoma that invaded the cavernous sinus approached through the medial corridor. The corridor's shape varied from tetrahedron to hexahedron. Comparing right and left sides, width averaged 3.6 ± 4.5 mm and 4.0 ± 4.4 mm, and height averaged 2.3 mm and 2.1 mm, respectively. About 35% of sides showed ample space for access into the cavernous sinus. Our case report of successful outcome lends support for the safety and efficacy of this endoscopic approach. Our re-examination of this particular surgical access into the LSC refines the understanding of the medial extra-sellar corridor as a main endoscopic access route to this compartment. Achieving safe access to the contents of the LSC, this 11th triangle is clinically relevant and potentially superior for select lesions in this region. Copyright © 2016 Elsevier Inc. All rights reserved.

Real time correlation function in a single phase space integral beyond the linearized semiclassical initial value representation.

PubMed

Liu, Jian; Miller, William H

2007-06-21

It is shown how quantum mechanical time correlation functions [defined, e.g., in Eq. (1.1)] can be expressed, without approximation, in the same form as the linearized approximation of the semiclassical initial value representation (LSC-IVR), or classical Wigner model, for the correlation function [cf. Eq. (2.1)], i.e., as a phase space average (over initial conditions for trajectories) of the Wigner functions corresponding to the two operators. The difference is that the trajectories involved in the LSC-IVR evolve classically, i.e., according to the classical equations of motion, while in the exact theory they evolve according to generalized equations of motion that are derived here. Approximations to the exact equations of motion are then introduced to achieve practical methods that are applicable to complex (i.e., large) molecular systems. Four such methods are proposed in the paper--the full Wigner dynamics (full WD) and the second order WD based on "Wigner trajectories" [H. W. Lee and M. D. Scully, J. Chem. Phys. 77, 4604 (1982)] and the full Donoso-Martens dynamics (full DMD) and the second order DMD based on "Donoso-Martens trajectories" [A. Donoso and C. C. Martens, Phys. Rev. Lett. 8722, 223202 (2001)]--all of which can be viewed as generalizations of the original LSC-IVR method. Numerical tests of the four versions of this new approach are made for two anharmonic model problems, and for each the momentum autocorrelation function (i.e., operators linear in coordinate or momentum operators) and the force autocorrelation function (nonlinear operators) have been calculated. These four new approximate treatments are indeed seen to be significant improvements to the original LSC-IVR approximation.

The immune receptor Trem1 cooperates with diminished DNA damage response to induce preleukemic stem cell expansion.

PubMed

Du, W; Amarachintha, S; Wilson, A; Pang, Q

2017-02-01

Fanconi anemia (FA) is an inherited bone marrow failure syndrome with extremely high risk of leukemic transformation. Here we investigate the relationship between DNA damage response (DDR) and leukemogenesis using the Fanca knockout mouse model. We found that chronic exposure of the Fanca -/- hematopoietic stem cells to DNA crosslinking agent mitomycin C in vivo leads to diminished DDR, and the emergence/expansion of pre-leukemia stem cells (pre-LSCs). Surprisingly, although genetic correction of Fanca deficiency in the pre-LSCs restores DDR and reduces genomic instability, but fails to prevent pre-LSC expansion or delay leukemia development in irradiated recipients. Furthermore, we identified transcription program underlying dysregulated DDR and cell migration, myeloid proliferation, and immune response in the Fanca -/- pre-LSCs. Forced expression of the downregulated DNA repair genes, Rad51c or Trp53i13, in the Fanca -/- pre-LSCs partially rescues DDR but has no effect on leukemia, whereas shRNA knockdown of the upregulated immune receptor genes Trem1 or Pilrb improves leukemia-related survival, but not DDR or genomic instability. Furthermore, Trem1 cooperates with diminished DDR in vivo to promote Fanca -/- pre-LSC expansion and leukemia development. Our study implicates diminishing DDR as a root cause of FA leukemogenesis, which subsequently collaborates with other signaling pathways for leukemogenic transformation.

Understanding pyrotechnic shock dynamics and response attenuation over distance

NASA Astrophysics Data System (ADS)

Ott, Richard J.

Pyrotechnic shock events used during stage separation on rocket vehicles produce high amplitude short duration structural response that can lead to malfunction or degradation of electronic components, cracks and fractures in brittle materials, local plastic deformation, and can cause materials to experience accelerated fatigue life. These transient loads propagate as waves through the structural media losing energy as they travel outward from the source. This work assessed available test data in an effort to better understand attenuation characteristics associated with wave propagation and attempted to update a historical standard defined by the Martin Marietta Corporation in the late 1960's using out of date data acquisition systems. Two data sets were available for consideration. The first data set came from a test that used a flight like cylinder used in NASA's Ares I-X program, and the second from a test conducted with a flat plate. Both data sets suggested that the historical standard was not a conservative estimate of shock attenuation with distance, however, the variation in the test data did not lend to recommending an update to the standard. Beyond considering attenuation with distance an effort was made to model the flat plate configuration using finite element analysis. The available flat plate data consisted of three groups of tests, each with a unique charge density linear shape charge (LSC) used to cut an aluminum plate. The model was tuned to a representative test using the lowest charge density LSC as input. The correlated model was then used to predict the other two cases by linearly scaling the input load based on the relative difference in charge density. The resulting model predictions were then compared with available empirical data. Aside from differences in amplitude due to nonlinearities associated with scaling the charge density of the LSC, the model predictions matched the available test data reasonably well. Finally, modeling best practices were recommended when using industry standard software to predict shock response on structures. As part of the best practices documented, a frequency dependent damping schedule that can be used in model development when no data is available is provided.

Sharing the Wonder of Gravitational Waves

NASA Astrophysics Data System (ADS)

Key, Joey Shapiro; LIGO Scientific Collaboration; Virgo Collaboration

2017-01-01

To share as widely as possible the excitement of the new discovery of gravitational waves, scientists in the LIGO Scientific Collaboration (LSC) and Virgo Collaboration prepared communication tools for a worldwide and diverse audience. This work included resources for traditional and social media outlets, preparing to engage at a wide range of levels and interests. The response to the LIGO discovery announcement indicated that the public is eager to engage with frontier physics. The LSC and Virgo outreach efforts hold lessons for broad STEM outreach including examples of citizen science initiatives and art +science collaboration as a way to inspire and engage a wide range of audiences.

Bubble nucleation in simple and molecular liquids via the largest spherical cavity method

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gonzalez, Miguel A., E-mail: m.gonzalez12@imperial.ac.uk; Department of Chemistry, Imperial College London, London SW7 2AZ; Abascal, José L. F.

2015-04-21

In this work, we propose a methodology to compute bubble nucleation free energy barriers using trajectories generated via molecular dynamics simulations. We follow the bubble nucleation process by means of a local order parameter, defined by the volume of the largest spherical cavity (LSC) formed in the nucleating trajectories. This order parameter simplifies considerably the monitoring of the nucleation events, as compared with the previous approaches which require ad hoc criteria to classify the atoms and molecules as liquid or vapor. The combination of the LSC and the mean first passage time technique can then be used to obtain themore » free energy curves. Upon computation of the cavity distribution function the nucleation rate and free-energy barrier can then be computed. We test our method against recent computations of bubble nucleation in simple liquids and water at negative pressures. We obtain free-energy barriers in good agreement with the previous works. The LSC method provides a versatile and computationally efficient route to estimate the volume of critical bubbles the nucleation rate and to compute bubble nucleation free-energies in both simple and molecular liquids.« less

Liquid scintillation counting methodology for 99Tc analysis. A remedy for radiopharmaceutical waste

DOE Office of Scientific and Technical Information (OSTI.GOV)

Khan, Mumtaz; Um, Wooyong

2015-08-13

This paper presents a new approach for liquid scintillation counting (LSC) analysis of single-radionuclide samples containing appreciable organic or inorganic quench. This work offers better analytical results than existing LSC methods for technetium-99 ( 99gTc) analysis with significant savings in analysis cost and time. The method was developed to quantify 99gTc in environmental liquid and urine samples using LSC. Method efficiency was measured in the presence of 1.9 to 11,900 ppm total dissolved solids. The quench curve was proved to be effective in the case of spiked 99gTc activity calculation for deionized water, tap water, groundwater, seawater, and urine samples.more » Counting efficiency was found to be 91.66% for Ultima Gold LLT (ULG-LLT) and Ultima Gold (ULG). Relative error in spiked 99gTc samples was ±3.98% in ULG and ULG-LLT cocktails. Minimum detectable activity was determined to be 25.3 mBq and 22.7 mBq for ULG-LLT and ULG cocktails, respectively. A pre-concentration factor of 1000 was achieved at 100°C for 100% chemical recovery.« less

Expression and assembly of a fully active antibody in algae

NASA Astrophysics Data System (ADS)

Mayfield, Stephen P.; Franklin, Scott E.; Lerner, Richard A.

2003-01-01

Although combinatorial antibody libraries have solved the problem of access to large immunological repertoires, efficient production of these complex molecules remains a problem. Here we demonstrate the efficient expression of a unique large single-chain (lsc) antibody in the chloroplast of the unicellular, green alga, Chlamydomonas reinhardtii. We achieved high levels of protein accumulation by synthesizing the lsc gene in chloroplast codon bias and by driving expression of the chimeric gene using either of two C. reinhardtii chloroplast promoters and 5' and 3' RNA elements. This lsc antibody, directed against glycoprotein D of the herpes simplex virus, is produced in a soluble form by the alga and assembles into higher order complexes in vivo. Aside from dimerization by disulfide bond formation, the antibody undergoes no detectable posttranslational modification. We further demonstrate that accumulation of the antibody can be modulated by the specific growth regime used to culture the alga, and by the choice of 5' and 3' elements used to drive expression of the antibody gene. These results demonstrate the utility of alga as an expression platform for recombinant proteins, and describe a new type of single chain antibody containing the entire heavy chain protein, including the Fc domain.

Patterns of Late Quaternary hydrologic variability and atmospheric change inferred from a Northern California speleothem

NASA Astrophysics Data System (ADS)

Oster, J. L.; Weisman, I. E.; Sharp, W. D.; Ibarra, D. E.

2017-12-01

The synthesis of hydrologically sensitive proxy records across western North America reveals spatial patterns of variability that persist, with some variation, over multiple temporal scales. For example, tree ring records from the last century highlight a distinct north-south dipole pattern in the response of regional precipitation anomalies to ENSO and the PDO, while a similar dipole pattern of wet and dry precipitation anomalies developed across the region in response to climate forcing at the Last Glacial Maximum (LGM). Hydrologically sensitive proxy records from the intervening transition zone can shed light on the stationarity and spatial scale of this pattern over time. Here we present records of δ18O and δ13C from a Lake Shasta Caverns stalagmite (LSC3) from Northern California that grew from 36 to 14 ka. This cave, located at 40.8°N, is situated within the transition zone and is well-positioned to enhance our understanding of regional precipitation patterns and moisture transport variability during the last glacial period and deglaciation. Six years of weekly rain isotope data indicate that varying atmospheric temperatures and moisture sources are primary controls on δ18O in Northern California precipitation. Increased δ18O and δ13C in LSC3 and slower stalagmite growth rates during MIS 2 suggest increased subtropical moisture but also dry conditions in Northern California. The δ13C record displays distinct millennial-scale oscillations during MIS 3, suggesting drier conditions also occurred during interstadials associated with Dansgaard-Oeschger cycles. The LSC3 δ18O record documents changes synchronous with δ18O in the Fort Stanton stalagmite in New Mexico, though sometimes in phase (e.g. during Heinrich Stadial 1; HS1) and sometimes anti-phased (e.g. during the Bölling-Alleröd). Likewise, the LSC3 δ13C record suggests a transition from wet to drier conditions during HS1 in marked contrast to many more southerly records that indicate wetter conditions later in HS1. These comparisons show that changes in Northern California climate were both in and out of phase with hydroclimate variations occurring to the south and southeast. Thus, the LSC3 record refines our understanding of spatial patterns of hydroclimatic change in western North America.

LTRC Annual Research Program : Fiscal Year July 1, 2017 - June 30, 2018.

DOT National Transportation Integrated Search

2017-06-01

FHWA Part II SPR Research Program FAP Number SPR-0010(34) & FHWA Funded Research Program & FHWA LTAP Funded Program & FHWA STP Funded Program & Federal & Self-Generated Funded Research Program & Other DOTD Funded Projects

LTRC Annual Research Program : Fiscal Year July 1, 2012-June 30, 2013

DOT National Transportation Integrated Search

2012-06-01

Contents: Budget Recap Sheets; Project Summary Sheets; FHWA Part II SPR Funded Research Program; FHWA IBRD Funded Research Program; FHWA LTAP Funded Program; FHWA STP Funded Technology Transfer & Education Program; State Funded Research Program; Fede...

LTRC annual research program : fiscal year July 1, 2011-June 30, 2012.

DOT National Transportation Integrated Search

2011-06-01

Contents: Budget Recaps Sheets; Project Summary Sheets; FHWA Part II SPR Funded Research Program; FHWA IBRD Funded Research Program; FHWA LTAP Funded Program; FHWA STP Funded Technology Transfer & Education Program; State Funded Research Program; Sel...

Coupling of Luminescent Solar Concentrators to Plasmonic Solar Cells

NASA Astrophysics Data System (ADS)

Wang, Shu-Yi

To make inexpensive solar cells is a continuous goal for solar photovoltaic (PV) energy industry. Thin film solar cells of various materials have been developed and continue to emerge in order to replace bulk silicon solar cells. A thin film solar cell not only uses less material but also requires a less expensive refinery process. In addition, other advantages coming along with small thickness are higher open circuit voltage and higher conversion efficiency. However, thin film solar cells, especially those made of silicon, have significant optical losses. In order to address this problem, this thesis investigates the spectral coupling of thin films PV to luminescent solar concentrators (LSC). LSC are passive devices, consisting of plastic sheets embedded with fluorescent dyes which absorb part of the incoming radiation spectrum and emit at specific wavelength. The emitted light is concentrated by total internal reflection to the edge of the sheet, where the PVs are placed. Since the light emitted from the LSC edge is usually in a narrow spectral range, it is possible to employ diverse strategies to enhance PV absorption at the peak of the emission wavelength. Employing plasmonic nanostructures has been shown to enhance absorption of thin films via forward scattering, diffraction and localized surface plasmon. These two strategies are theoretically investigated here for improving the absorption and elevating the output power of a thin film solar cell. First, the idea of spectral coupling of luminescent solar concentrators to plasmonic solar cells is introduced to assess its potential for increasing the power output. This study is carried out employing P3HT/PC60BM organic solar cells and LSC with Lumogen Red dyes. A simplified spectral coupling analysis is employed to predict the power density, considering the output spectrum of the LSC equivalent to the emission spectrum of the dye and neglecting any angular dependence. Plasmonic tuning is conducted to enhance absorption at the emission peak of the dye. A factorial increase in the output power density of coupled PV as compared to PV exposed directly to solar spectrum is observed for high light concentration on the edge. These initial results motivated a more in-depth study of coupled LSC-PV system, which took into account the radiative transport inside the realistic LSC. These investigations were carried out on LSCs using Lumogen Red305 and Rhodamine 6G dyes coupled to pristine and plasmonic ultra-thin film silicon solar cells. Prediction based on detailed balance shows that the coupled LSC-plasmonic solar cell can generate 63.7 mW/cm2 with a photocurrent density of 71.3 mA/cm2 which is higher than that of cSi solar cells available on current market. The second part of the thesis focuses on PV absorption enhancement techniques. First, the effect of vertical positioning of plasmonic nanostructures on absorption enhancement was theoretically investigated to understand which one of the three mechanisms usually responsible for the enhancement (forward scattering, diffraction and localized surface plamson) plays the dominant role. Simulation results suggested that the maximum enhancement occurred when placing the nanostructures in the rear side of the cell because of longer path length due to scattering. The experimental effort then switched focus on substrate patterning, which is a less expensive alternative to plasmonic absorption enhancement. Specifically, a nanostructured substrate was prepared by a simple electrochemical process based on two-step aluminum anodization technique. The absorption of thin film silicon deposited on these substrates showed a broadband enhancement. The overall photocurrent density was up to 40% higher than that of films deposited on flat substrates. In conclusion, the studies carried out in this thesis indicate that spectral coupling of LSCs to thin film solar cells could lead to significant improvements in PV output power density. Moreover, while the absorption of thin film solar cells can be enhanced by plasmonic nanostructures, it is shown that alternative methods, such as direct deposition of the films on inexpensively nanostructured substrates could also be employed to obtain significant enhancements. Combining these strategies may lead to inexpensive solar power harvesting systems with significant economic benefits. These strategies are not material-specific but applicable to a wide range of thin film solar cells.

LTRC annual research program : fiscal year July 1, 2015 - June 30, 2016.

DOT National Transportation Integrated Search

2015-06-01

Contents: Budget Recap Sheets; Project Summary Sheets; FHWA Part II SPR Funded Research Program; FHWA LTAP Funded Program; FHWA STP Funded Technology Transfer & Education Program; State Funded Research Program; Self-Generated Funded Research; Other D...

24 CFR 214.311 - Funding.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Funding. 214.311 Section 214.311... PROGRAM Program Administration § 214.311 Funding. (a) HUD funding. HUD approval or program participation does not guarantee funding from HUD. Funding for the Housing Counseling program depends on...

Overhead View of Pathfinder Landing Site

NASA Technical Reports Server (NTRS)

1997-01-01

Planimetric (overhead view) map of the landing site, to a distance of 20 meters from the spacecraft. North is at the top in this and Plates 3-5. To produce this map, images were geometrically projected onto an assumed mean surface representing the ground. Features above the ground plane (primarily rocks) therefore appear displaced radially outward; the amount of distortion increases systematically with distance. The upper surfaces of the lander and rover also appear enlarged and displaced because of their height. Primary grid (white) is based on the Landing Site Cartographic (LSC) coordinate system, defined with X eastward, Y north, and Z up, and origin located at the mean ground surface immediately beneath the deployed position of the IMP camera gimbal center. Secondary ticks (cyan) are based on the Mars local level (LL) frame, which has X north, Y east, Z down, with origin in the center of the lander baseplate. Rover positions (including APXS measurements) are commonly reported in the LL frame. Yellow grid shows polar coordinates based on the LSC system. Cartographic image processing by U.S. Geological Survey.

NOTE: original caption as published in Science Magazine

Mars Pathfinder is the second in NASA's Discovery program of low-cost spacecraft with highly focused science goals. The Jet Propulsion Laboratory, Pasadena, CA, developed and manages the Mars Pathfinder mission for NASA's Office of Space Science, Washington, D.C. JPL is a division of the California Institute of Technology (Caltech).

Analytical method for measuring cosmogenic 35S in natural waters

DOE PAGES

Uriostegui, Stephanie H.; Bibby, Richard K.; Esser, Bradley K.; ...

2015-05-18

Here, cosmogenic sulfur-35 in water as dissolved sulfate ( 35SO 4) has successfully been used as an intrinsic hydrologic tracer in low-SO 4, high-elevation basins. Its application in environmental waters containing high SO 4 concentrations has been limited because only small amounts of SO 4 can be analyzed using current liquid scintillation counting (LSC) techniques. We present a new analytical method for analyzing large amounts of BaSO 4 for 35S. We quantify efficiency gains when suspending BaSO 4 precipitate in Inta-Gel Plus cocktail, purify BaSO 4 precipitate to remove dissolved organic matter, mitigate interference of radium-226 and its daughter productsmore » by selection of high purity barium chloride, and optimize LSC counting parameters for 35S determination in larger masses of BaSO 4. Using this improved procedure, we achieved counting efficiencies that are comparable to published LSC techniques despite a 10-fold increase in the SO 4 sample load. 35SO 4 was successfully measured in high SO 4 surface waters and groundwaters containing low ratios of 35S activity to SO 4 mass demonstrating that this new analytical method expands the analytical range of 35SO 4 and broadens the utility of 35SO 4 as an intrinsic tracer in hydrologic settings.« less

Novel strategies for targeting leukemia stem cells: sounding the death knell for blood cancer

PubMed Central

Chavez-Gonzalez, Antonieta; Bakhshinejad, Babak; Pakravan, Katayoon

2018-01-01

Background Cancer stem cells (CSCs), also known as tumor-initiating cells (TICs), are characterized by high self-renewal and multi-lineage differentiation capacities. CSCs are thought to play indispensable roles in the initiation, progression and metastasis of many types of cancer. Leukemias are thought to be initiated and maintained by a specific sub-type of CSC, the leukemia stem cell (LSC). An important feature of LSCs is their resistance to standard therapy, which may lead to relapse. Increasing efforts are aimed at developing novel therapeutic strategies that selectively target LSCs, while sparing their normal counterparts and, thus, minimizing adverse treatment-associated side-effects. These LSC targeting therapies aim to eradicate LSCs through affecting mechanisms that control their survival, self-renewal, differentiation, proliferation and cell cycle progression. Some LSC targeting therapies have already been proven successful in pre-clinical studies and they are now being tested in clinical studies, mainly in combination with conventional treatment regimens. Conclusions A growing body of evidence indicates that the selective targeting of LSCs represents a promising approach to improve disease outcome. Beyond doubt, the CSC hypothesis has added a new dimension to the area of anticancer research, thereby paving the way for shaping a new trend in cancer therapy. PMID:27678246

Bioprocessing of a stored mixed liquid waste

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wolfram, J.H.; Rogers, R.D.; Finney, R.

1995-12-31

This paper describes the development and results of a demonstration for a continuous bioprocess for mixed waste treatment. A key element of the process is an unique microbial strain which tolerates high levels of aromatic solvents and surfactants. This microorganism is the biocatalysis of the continuous flow system designed for the processing of stored liquid scintillation wastes. During the past year a process demonstration has been conducted on commercial formulation of liquid scintillation cocktails (LSC). Based on data obtained from this demonstration, the Ohio EPA granted the Mound Applied Technologies Lab a treatability permit allowing the limited processing of actualmore » mixed waste. Since August 1994, the system has been successfully processing stored, {open_quotes}hot{close_quotes} LSC waste. The initial LSC waste fed into the system contained 11% pseudocumene and detectable quantities of plutonium. Another treated waste stream contained pseudocumene and tritium. Data from this initial work shows that the hazardous organic solvent, and pseudocumene have been removed due to processing, leaving the aqueous low level radioactive waste. Results to date have shown that living cells are not affected by the dissolved plutonium and that 95% of the plutonium was sorbed to the biomass. This paper discusses the bioprocess, rates of processing, effluent, and the implications of bioprocessing for mixed waste management.« less

Modelling local GPS/levelling geoid undulations using artificial neural networks

NASA Astrophysics Data System (ADS)

Kavzoglu, T.; Saka, M. H.

2005-04-01

The use of GPS for establishing height control in an area where levelling data are available can involve the so-called GPS/levelling technique. Modelling of the GPS/levelling geoid undulations has usually been carried out using polynomial surface fitting, least-squares collocation (LSC) and finite-element methods. Artificial neural networks (ANNs) have recently been used for many investigations, and proven to be effective in solving complex problems represented by noisy and missing data. In this study, a feed-forward ANN structure, learning the characteristics of the training data through the back-propagation algorithm, is employed to model the local GPS/levelling geoid surface. The GPS/levelling geoid undulations for Istanbul, Turkey, were estimated from GPS and precise levelling measurements obtained during a field study in the period 1998-99. The results are compared to those produced by two well-known conventional methods, namely polynomial fitting and LSC, in terms of root mean square error (RMSE) that ranged from 3.97 to 5.73 cm. The results show that ANNs can produce results that are comparable to polynomial fitting and LSC. The main advantage of the ANN-based surfaces seems to be the low deviations from the GPS/levelling data surface, which is particularly important for distorted levelling networks.

Age-related differences in BOLD modulation to cognitive control costs in a multitasking paradigm: Global switch, local switch, and compatibility-switch costs.

PubMed

Nashiro, Kaoru; Qin, Shuo; O'Connell, Margaret A; Basak, Chandramallika

2018-05-15

It is well documented that older adults recruit additional brain regions compared to those recruited by younger adults while performing a wide variety of cognitive tasks. However, it is unclear how such age-related over-recruitment interacts with different types of cognitive control, and whether this over-recruitment is compensatory. To test this, we used a multitasking paradigm, which allowed us to examine age-related over-activation associated with three types of cognitive costs (i.e., global switch, local switch, compatibility-switch costs). We found age-related impairments in global switch cost (GSC), evidenced by slower response times for maintaining and coordinating two tasks vs. performing only one task. However, no age-related declines were observed in either local switch cost (LSC), a cognitive cost associated with switching between the two tasks while maintaining two task loads, or compatibility-switch cost (CSC), a cognitive cost associated with incompatible vs. compatible stimulus-response mappings across the two tasks. The fMRI analyses allowed for identification of distinct cognitive cost-sensitive brain regions associated with GSC and LSC. In fronto-parietal GSC and LSC regions, older adults' increased activations were associated with poorer performance (greater costs), whereas a reverse relationship was observed in younger adults. Older adults also recruited additional fronto-parietal brain regions outside the cognitive cost-sensitive areas, which was associated with poorer performance or no behavioral benefits. Our results suggest that older adults exhibit a combination of inefficient activation within cognitive cost-sensitive regions, specifically the GSC and LSC regions, and non-compensatory over-recruitment in age-sensitive regions. Age-related declines in global switching, compared to local switching, was observed earlier in old age at both neural and behavioral levels. Copyright © 2018 Elsevier Inc. All rights reserved.

The Linum usitatissimum L. plastome reveals atypical structural evolution, new editing sites, and the phylogenetic position of Linaceae within Malpighiales.

PubMed

de Santana Lopes, Amanda; Pacheco, Túlio Gomes; Santos, Karla Gasparini Dos; Vieira, Leila do Nascimento; Guerra, Miguel Pedro; Nodari, Rubens Onofre; de Souza, Emanuel Maltempi; de Oliveira Pedrosa, Fábio; Rogalski, Marcelo

2018-02-01

The plastome of Linum usitatissimum was completely sequenced allowing analyses of evolution of genome structure, RNA editing sites, molecular markers, and indicating the position of Linaceae within Malpighiales. Flax (Linum usitatissimum L.) is an economically important crop used as food, feed, and industrial feedstock. It belongs to the Linaceae family, which is noted by high morphological and ecological diversity. Here, we reported the complete sequence of flax plastome, the first species within Linaceae family to have the plastome sequenced, assembled and characterized in detail. The plastome of flax is a circular DNA molecule of 156,721 bp with a typical quadripartite structure including two IRs of 31,990 bp separating the LSC of 81,767 bp and the SSC of 10,974 bp. It shows two expansion events from IRB to LSC and from IRB to SSC, and a contraction event in the IRA-LSC junction, which changed significantly the size and the gene content of LSC, SSC and IRs. We identified 109 unique genes and 2 pseudogenes (rpl23 and ndhF). The plastome lost the conserved introns of clpP gene and the complete sequence of rps16 gene. The clpP, ycf1, and ycf2 genes show high nucleotide and aminoacid divergence, but they still possibly retain the functionality. Moreover, we also identified 176 SSRs, 20 tandem repeats, and 39 dispersed repeats. We predicted in 18 genes a total of 53 RNA editing sites of which 32 were not found before in other species. The phylogenetic inference based on 63 plastid protein-coding genes of 38 taxa supports three major clades within Malpighiales order. One of these clades has flax (Linaceae) sister to Chrysobalanaceae family, differing from earlier studies that included Linaceae into the euphorbioid clade.

Improved chemical and electrochemical stability of perovskite oxides with less reducible cations at the surface

DOE PAGES

Tsvetkov, Nikolai; Lu, Qiyang; Sun, Lixin; ...

2016-06-13

Segregation and phase separation of aliovalent dopants on perovskite oxide (ABO 3 ) surfaces are detrimental to the performance of energy conversion systems such as solid oxide fuel/electrolysis cells and catalysts for thermochemical H 2 O and CO 2 splitting. One key reason behind the instability of perovskite oxide surfaces is the electrostatic attraction of the negatively charged A-site dopants (for example, Sr La ') by the positively charged oxygen vacancies (Vmore » $$••\\atop{o}$$) enriched at the surface. Here we show that reducing the surface V $$••\\atop{o}$$ concentration improves the oxygen surface exchange kinetics and stability significantly, albeit contrary to the well-established understanding that surface oxygen vacancies facilitate reactions with O 2 molecules. We take La 0.8 Sr 0.2 CoO 3 (LSC) as a model perovskite oxide, and modify its surface with additive cations that are more and less reducible than Co on the B-site of LSC. By using ambient-pressure X-ray absorption and photoelectron spectroscopy, we proved that the dominant role of the less reducible cations is to suppress the enrichment and phase separation of Sr while reducing the concentration of V $$••\\atop{o}$$ and making the LSC more oxidized at its surface. Consequently, we found that these less reducible cations significantly improve stability, with up to 30 times faster oxygen exchange kinetics after 54 h in air at 530 °C achieved by Hf addition onto LSC. Finally, the results revealed a 'volcano' relation between the oxygen exchange kinetics and the oxygen vacancy formation enthalpy of the binary oxides of the additive cations. This volcano relation highlights the existence of an optimum surface oxygen vacancy concentration that balances the gain in oxygen exchange kinetics and the chemical stability loss.« less

Improved chemical and electrochemical stability of perovskite oxides with less reducible cations at the surface

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tsvetkov, Nikolai; Lu, Qiyang; Sun, Lixin

Segregation and phase separation of aliovalent dopants on perovskite oxide (ABO 3 ) surfaces are detrimental to the performance of energy conversion systems such as solid oxide fuel/electrolysis cells and catalysts for thermochemical H 2 O and CO 2 splitting. One key reason behind the instability of perovskite oxide surfaces is the electrostatic attraction of the negatively charged A-site dopants (for example, Sr La ') by the positively charged oxygen vacancies (Vmore » $$••\\atop{o}$$) enriched at the surface. Here we show that reducing the surface V $$••\\atop{o}$$ concentration improves the oxygen surface exchange kinetics and stability significantly, albeit contrary to the well-established understanding that surface oxygen vacancies facilitate reactions with O 2 molecules. We take La 0.8 Sr 0.2 CoO 3 (LSC) as a model perovskite oxide, and modify its surface with additive cations that are more and less reducible than Co on the B-site of LSC. By using ambient-pressure X-ray absorption and photoelectron spectroscopy, we proved that the dominant role of the less reducible cations is to suppress the enrichment and phase separation of Sr while reducing the concentration of V $$••\\atop{o}$$ and making the LSC more oxidized at its surface. Consequently, we found that these less reducible cations significantly improve stability, with up to 30 times faster oxygen exchange kinetics after 54 h in air at 530 °C achieved by Hf addition onto LSC. Finally, the results revealed a 'volcano' relation between the oxygen exchange kinetics and the oxygen vacancy formation enthalpy of the binary oxides of the additive cations. This volcano relation highlights the existence of an optimum surface oxygen vacancy concentration that balances the gain in oxygen exchange kinetics and the chemical stability loss.« less

Reproducibility of Direct Quantitative Measures of Cortical Bone Micro-architecture of the Distal Radius and Tibia by HR-pQCT

PubMed Central

Burghardt, Andrew J.; Buie, Helen R.; Laib, Andres; Majumdar, Sharmila; Boyd, Steven K.

2010-01-01

Quantitative cortical micro-architectural endpoints are important for understanding structure-function relations in the context of fracture risk and therapeutic efficacy. This technique study details new image-processing methods to automatically segment and directly quantify cortical density, geometry, and micro-architecture from HR-pQCT images of the distal radius and tibia. An automated segmentation technique was developed to identify the periosteal and endosteal margins of the distal radius and tibia, and detect intra-cortical pore space morphologically consistent with Haversian canals. The reproducibility of direct quantitative cortical bone indices based on this method was assessed in a pooled dataset of 56 subjects with two repeat acquisitions for each site. The in vivo precision error was characterized using root mean square coefficient of variation (RMSCV%) from which, the least significant change (LSC) was calculated. Bland-Altman plots were used to characterize bias in the precision estimates. The reproducibility of cortical density and cross-sectional area measures was high (RMSCV <1% and <1.5%, respectively) with good agreement between young and elder medians. The LSC for cortical porosity (Ct.Po) was somewhat smaller in the radius (0.58%) compared with the distal tibia (0.84%) and significantly different between young and elder medians in the distal tibia (LSC: 0.75% vs. 0.92%; p<0.001). The LSC for pore diameter and distribution (Po.Dm and Po.Dm.SD) ranged between 15 and 23μm. Bland-Altman analysis revealed moderate bias for integral measures of area and volume, but not density nor microarchitecture. This study indicates HR-pQCT measures of cortical bone density and architecture can be measured in vivo with high reproducibility and limited bias across a biologically relevant range of values. The results of this study provide informative data for the design of future clinical studies of bone quality. PMID:20561906

75 FR 32480 - Funding Opportunity: Affordable Care Act Medicare Beneficiary Outreach and Assistance Program...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-08

... Care Act Medicare Beneficiary Outreach and Assistance Program Funding for Title VI Native American Programs Purpose of Notice: Availability of funding opportunity announcement. Funding Opportunity Title/Program Name: Affordable Care Act Medicare Beneficiary Outreach and Assistance Program Funding for Title...

Applicability of Taylor's hypothesis in thermally driven turbulence

PubMed Central

Verma, Mahendra K.

2018-01-01

In this paper, we show that, in the presence of large-scale circulation (LSC), Taylor’s hypothesis can be invoked to deduce the energy spectrum in thermal convection using real-space probes, a popular experimental tool. We perform numerical simulation of turbulent convection in a cube and observe that the velocity field follows Kolmogorov’s spectrum (k−5/3). We also record the velocity time series using real-space probes near the lateral walls. The corresponding frequency spectrum exhibits Kolmogorov’s spectrum (f−5/3), thus validating Taylor’s hypothesis with the steady LSC playing the role of a mean velocity field. The aforementioned findings based on real-space probes provide valuable inputs for experimental measurements used for studying the spectrum of convective turbulence. PMID:29765668

Applicability of Taylor's hypothesis in thermally driven turbulence

NASA Astrophysics Data System (ADS)

Kumar, Abhishek; Verma, Mahendra K.

2018-04-01

In this paper, we show that, in the presence of large-scale circulation (LSC), Taylor's hypothesis can be invoked to deduce the energy spectrum in thermal convection using real-space probes, a popular experimental tool. We perform numerical simulation of turbulent convection in a cube and observe that the velocity field follows Kolmogorov's spectrum (k-5/3). We also record the velocity time series using real-space probes near the lateral walls. The corresponding frequency spectrum exhibits Kolmogorov's spectrum (f-5/3), thus validating Taylor's hypothesis with the steady LSC playing the role of a mean velocity field. The aforementioned findings based on real-space probes provide valuable inputs for experimental measurements used for studying the spectrum of convective turbulence.

31 CFR 205.16 - What special rules apply to Federal assistance programs and projects funded by the Federal...

Code of Federal Regulations, 2012 CFR

2012-07-01

... assistance programs and projects funded by the Federal Highway Trust Fund? 205.16 Section 205.16 Money and... special rules apply to Federal assistance programs and projects funded by the Federal Highway Trust Fund? The following applies to Federal assistance programs and projects funded out of the Federal Highway...

31 CFR 205.16 - What special rules apply to Federal assistance programs and projects funded by the Federal...

Code of Federal Regulations, 2013 CFR

2013-07-01

... assistance programs and projects funded by the Federal Highway Trust Fund? 205.16 Section 205.16 Money and... special rules apply to Federal assistance programs and projects funded by the Federal Highway Trust Fund? The following applies to Federal assistance programs and projects funded out of the Federal Highway...

31 CFR 205.16 - What special rules apply to Federal assistance programs and projects funded by the Federal...

Code of Federal Regulations, 2014 CFR

2014-07-01

... assistance programs and projects funded by the Federal Highway Trust Fund? 205.16 Section 205.16 Money and... special rules apply to Federal assistance programs and projects funded by the Federal Highway Trust Fund? The following applies to Federal assistance programs and projects funded out of the Federal Highway...

31 CFR 205.16 - What special rules apply to Federal assistance programs and projects funded by the Federal...

Code of Federal Regulations, 2010 CFR

2010-07-01

... assistance programs and projects funded by the Federal Highway Trust Fund? 205.16 Section 205.16 Money and... special rules apply to Federal assistance programs and projects funded by the Federal Highway Trust Fund? The following applies to Federal assistance programs and projects funded out of the Federal Highway...

31 CFR 205.16 - What special rules apply to Federal assistance programs and projects funded by the Federal...

Code of Federal Regulations, 2011 CFR

2011-07-01

... assistance programs and projects funded by the Federal Highway Trust Fund? 205.16 Section 205.16 Money and... special rules apply to Federal assistance programs and projects funded by the Federal Highway Trust Fund? The following applies to Federal assistance programs and projects funded out of the Federal Highway...

Liver Biopsy

MedlinePlus

... Funding Current Funding Opportunities Research Programs & Contacts Human Subjects Research Funding Process Research Training & Career Development Funded ... Funding Current Funding Opportunities Research Programs & Contacts Human Subjects Research Funding Process Research Training & Career Development Funded ...

31 CFR 1024.220 - Customer identification programs for mutual funds.

Code of Federal Regulations, 2011 CFR

2011-07-01

... mutual funds. 1024.220 Section 1024.220 Money and Finance: Treasury Regulations Relating to Money and... FUNDS Programs § 1024.220 Customer identification programs for mutual funds. (a) Customer identification program: minimum requirements—(1) In general. A mutual fund must implement a written Customer...

Interactions between Energy Efficiency Programs funded under the Recovery Act and Utility Customer-Funded Energy Efficiency Programs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Goldman, Charles A.; Stuart, Elizabeth; Hoffman, Ian

2011-02-25

Since the spring of 2009, billions of federal dollars have been allocated to state and local governments as grants for energy efficiency and renewable energy projects and programs. The scale of this American Reinvestment and Recovery Act (ARRA) funding, focused on 'shovel-ready' projects to create and retain jobs, is unprecedented. Thousands of newly funded players - cities, counties, states, and tribes - and thousands of programs and projects are entering the existing landscape of energy efficiency programs for the first time or expanding their reach. The nation's experience base with energy efficiency is growing enormously, fed by federal dollars andmore » driven by broader objectives than saving energy alone. State and local officials made countless choices in developing portfolios of ARRA-funded energy efficiency programs and deciding how their programs would relate to existing efficiency programs funded by utility customers. Those choices are worth examining as bellwethers of a future world where there may be multiple program administrators and funding sources in many states. What are the opportunities and challenges of this new environment? What short- and long-term impacts will this large, infusion of funds have on utility customer-funded programs; for example, on infrastructure for delivering energy efficiency services or on customer willingness to invest in energy efficiency? To what extent has the attribution of energy savings been a critical issue, especially where administrators of utility customer-funded energy efficiency programs have performance or shareholder incentives? Do the new ARRA-funded energy efficiency programs provide insights on roles or activities that are particularly well-suited to state and local program administrators vs. administrators or implementers of utility customer-funded programs? The answers could have important implications for the future of U.S. energy efficiency. This report focuses on a selected set of ARRA-funded energy efficiency programs administered by state energy offices: the State Energy Program (SEP) formula grants, the portion of Energy Efficiency and Conservation Block Grant (EECBG) formula funds administered directly by states, and the State Energy Efficient Appliance Rebate Program (SEEARP). Since these ARRA programs devote significant monies to energy efficiency and serve similar markets as utility customer-funded programs, there are frequent interactions between programs. We exclude the DOE low-income weatherization program and EECBG funding awarded directly to the over 2,200 cities, counties and tribes from our study to keep its scope manageable. We summarize the energy efficiency program design and funding choices made by the 50 state energy offices, 5 territories and the District of Columbia. We then focus on the specific choices made in 12 case study states. These states were selected based on the level of utility customer program funding, diversity of program administrator models, and geographic diversity. Based on interviews with more than 80 energy efficiency actors in those 12 states, we draw observations about states strategies for use of Recovery Act funds. We examine interactions between ARRA programs and utility customer-funded energy efficiency programs in terms of program planning, program design and implementation, policy issues, and potential long-term impacts. We consider how the existing regulatory policy framework and energy efficiency programs in these 12 states may have impacted development of these selected ARRA programs. Finally, we summarize key trends and highlight issues that evaluators of these ARRA programs may want to examine in more depth in their process and impact evaluations.« less

31 CFR 1024.210 - Anti-money laundering programs for mutual funds.

Code of Federal Regulations, 2011 CFR

2011-07-01

... mutual funds. 1024.210 Section 1024.210 Money and Finance: Treasury Regulations Relating to Money and... FUNDS Programs § 1024.210 Anti-money laundering programs for mutual funds. (a) Effective July 24, 2002, each mutual fund shall develop and implement a written anti-money laundering program reasonably...

Tensile Lattice Strain Accelerates Oxygen Surface Exchange and Diffusion in La1–xSrxCoO3−δ Thin Films

PubMed Central

2013-01-01

The influence of lattice strain on the oxygen exchange kinetics and diffusion in oxides was investigated on (100) epitaxial La1–xSrxCoO3−δ (LSC) thin films grown by pulsed laser deposition. Planar tensile and compressively strained LSC films were obtained on single-crystalline SrTiO3 and LaAlO3. 18O isotope exchange depth profiling with ToF-SIMS was employed to simultaneously measure the tracer surface exchange coefficient k* and the tracer diffusion coefficient D* in the temperature range 280–475 °C. In accordance with recent theoretical findings, much faster surface exchange (∼4 times) and diffusion (∼10 times) were observed for the tensile strained films compared to the compressively strained films in the entire temperature range. The same strain effect—tensile strain leading to higher k* and D*—was found for different LSC compositions (x = 0.2 and x = 0.4) and for surface-etched films. The temperature dependence of k* and D* is discussed with respect to the contributions of strain states, formation enthalpy of oxygen vacancies, and vacancy mobility at different temperatures. Our findings point toward the control of oxygen surface exchange and diffusion kinetics by means of lattice strain in existing mixed conducting oxides for energy conversion applications. PMID:23527691

Radiocarbon application in environmental science and archaeology in Croatia

NASA Astrophysics Data System (ADS)

Krajcar Bronić, I.; Obelić, B.; Horvatinčić, N.; Barešić, J.; Sironić, A.; Minichreiter, K.

2010-07-01

Radiocarbon is a cosmogenic radioisotope equally distributed throughout the troposphere and biosphere. This fact enables its most common application—radiocarbon dating. Natural equilibrium of radiocarbon has been disturbed by diverse anthropogenic activities during the last ˜150 years, enabling also the use of 14C in various environmental applications. Here we present three types of studies by using 14C that were performed in the Zagreb Radiocarbon Laboratory. 14C in atmospheric CO 2 has been monitored at several sites with various anthropogenic influences and the difference between the clean-air sites, the industrial city and the vicinity of a nuclear power plant has been established. 14C has been applied in geochronology of karst areas, especially in dating of tufa, speleothems and lake sediments, as well as in studies of geochemical carbon cycle. 14C has been used in various archaeological studies, among which the dating of the early Neolithic settlements in Croatia is presented. In these studies 14C was measured by radiometric techniques, i.e., by gas proportional counting and more recently by liquid scintillation counting (LSC). Two sample preparation techniques for LSC measurement were used: benzene synthesis for archaeological dating and other applications that require better precision, and direct absorption of CO 2 for monitoring purposes. The presented results show that various studies by using 14C can be successfully performed by the LSC technique, providing a large enough sample (>1 g of carbon).

Clinical and laboratory applications of slide-based cytometry with the LSC, SFM, and the iCYTE imaging cytometer instruments

NASA Astrophysics Data System (ADS)

Bocsi, Jozsef; Luther, Ed; Mittag, Anja; Jensen, Ingo; Sack, Ulrich; Lenz, Dominik; Trezl, Lajos; Varga, Viktor S.; Molnar, Beea; Tarnok, Attila

2004-06-01

Background: Slide based cytometry (SBC) is a technology for the rapid stoichiometric analysis of cells fixed to surfaces. Its applications are highly versatile and ranges from the clinics to high throughput drug discovery. SBC is realized in different instruments such as the Laser Scanning Cytometer (LSC) and Scanning Fluorescent Microscope (SFM) and the novel inverted microscope based iCyte image cytometer (Compucyte Corp.). Methods: Fluorochrome labeled specimens were immobilized on microscopic slides. They were placed on a conventional fluorescence microscope and analyzed by photomultiplayers or digital camera. Data comparable to flow cytometry were generated. In addition, each individual event could be visualized. Applications: The major advantage of instruments is the combination of two features: a) the minimal sample volume needed, and b) the connection of fluorescence data and morphological information. Rare cells were detected, frequency of apoptosis by myricetin formaldehyde and H2O2 mixtures was determined;. Conclusion: LSC, SFM and the novel iCyte have a wide spectrum of applicability in SBC and can be introduced as a standard technology for multiple settings. In addition, the iCyte and SFM instrument is suited for high throughput screening by automation and may be in future adapted to telepathology due to their high quality images. (This study was supported by the IZKF-Leipzig, Germany and T 034245 OTKA, Hungary)

Azimuthal diffusion of the large-scale circulation of turbulent Rayleight-Bénard convection

NASA Astrophysics Data System (ADS)

He, Xiaozhou; van Gils, Dennis P. M.; Bodenschatz, Eberhard; Ahlers, Guenter

2015-11-01

We present measurements of the azimuthal orientation θ0 (t) of the large-scale circulation (LSC) of turbulent Rayleight-Bénard convection. The sample was a cylinder with height and diameter equal to 1.12 m. We used compressed SF6 gas at pressures up to 19 bars as the fluid. The measurements covered the Rayleigh-number range 1012 <= Ra <=1014 at a Prandtl number Pr ~= 0 . 80 . We found that the preferred orientation of the LSC upflow was aligned to the West, consistent with Earth's Coriolis force. The LSC azimuthal dynamics was diffusive, driven by the small-scale turbulent fluctuations. For Ra <=1013 the Reynolds number Reθ˙ based on the azimuthal diffusivity had a Ra dependence similar to that seen for 109 <= Ra <=1011 and Pr = 4 . 38 . The Pr dependence Reθ˙ ~Prα with α ~= - 1 . 2 was the same as that found for the Reynolds number based on the root-mean-square fluctuation velocity in the interior bulk flow. For Ra = Ra1* ~= 2 ×1013 Reθ˙ showed the ultimate-state transition and for Ra >= Ra2* ~= 8 ×1013 it had a Ra dependence with an exponent of 0 . 40 +/- 0 . 02 . Supported by the Max Planck Society, the Volkswagenstiftung, the DFD Sonderforschungsbereich SFB963, and NSF Grant DMR11-58514.

Scale-up of a Luminescent Solar Concentrator-Based Photomicroreactor via Numbering-up.

PubMed

Zhao, Fang; Cambié, Dario; Janse, Jeroen; Wieland, Eric W; Kuijpers, Koen P L; Hessel, Volker; Debije, Michael G; Noël, Timothy

2018-01-02

The use of solar energy to power chemical reactions is a long-standing dream of the chemical community. Recently, visible-light-mediated photoredox catalysis has been recognized as the ideal catalytic transformation to convert solar energy into chemical bonds. However, scaling photochemical transformations has been extremely challenging due to Bouguer-Lambert-Beer law. Recently, we have pioneered the development of luminescent solar concentrator photomicroreactors (LSC-PMs), which display an excellent energy efficiency. These devices harvest solar energy, convert the broad solar energy spectrum to a narrow-wavelength region, and subsequently waveguide the re-emitted photons to the reaction channels. Herein, we report on the scalability of such LSC-PMs via a numbering-up strategy. Paramount in our work was the use of molds that were fabricated via 3D printing. This allowed us to rapidly produce many different prototypes and to optimize experimentally key design aspects in a time-efficient fashion. Reactors up to 32 parallel channels have been fabricated that display an excellent flow distribution using a bifurcated flow distributor (standard deviations below 10%). This excellent flow distribution was crucial to scale up a model reaction efficiently, displaying yields comparable to those obtained in a single-channel device. We also found that interchannel spacing is an important and unique design parameter for numbered-up LSC-PMs, which influences greatly the photon flux experienced within the reaction channels.

Multifunctional Nitrogen-Doped Loofah Sponge Carbon Blocking Layer for High-Performance Rechargeable Lithium Batteries.

PubMed

Gu, Xingxing; Tong, Chuan-Jia; Rehman, Sarish; Liu, Li-Min; Hou, Yanglong; Zhang, Shanqing

2016-06-29

Low-cost, long-life, and high-performance lithium batteries not only provide an economically viable power source to electric vehicles and smart electricity grids but also address the issues of the energy shortage and environmental sustainability. Herein, low-cost, hierarchically porous, and nitrogen-doped loofah sponge carbon (N-LSC) derived from the loofah sponge has been synthesized via a simple calcining process and then applied as a multifunctional blocking layer for Li-S, Li-Se, and Li-I2 batteries. As a result of the ultrahigh specific area (2551.06 m(2) g(-1)), high porosity (1.75 cm(3) g(-1)), high conductivity (1170 S m(-1)), and heteroatoms doping of N-LSC, the resultant Li-S, Li-Se, and Li-I2 batteries with the N-LSC-900 membrane deliver outstanding electrochemical performance stability in all cases, i.e., high reversible capacities of 623.6 mA h g(-1) at 1675 mA g(-1) after 500 cycles, 350 mA h g(-1) at 1356 mA g(-1) after 1000 cycles, and 150 mA h g(-1) at 10550 mA g(-1) after 5000 cycles, respectively. The successful application to Li-S, Li-Se, and Li-I2 batteries suggests that loofa sponge carbon could play a vital role in modern rechargeable battery industries as a universal, cost-effective, environmentally friendly, and high-performance blocking layer.

Application of Quantum Dot nanocrystal in Luminescent solar concentrators

NASA Astrophysics Data System (ADS)

Bakhoda, Shokoufeh; Khalaji Assadi, Morteza; Ahmadi Kandjani, Sohrab; Kayiem, Hussain H. Al; Hussain Bhat, Aamir

2018-03-01

The basic design of luminescent solar concentrator is a transparent plate doped with an appropriate luminescent material (organic dyes, quantum dots), which is able to absorb sunlight (direct and diffuse), and then guides photons produced by photoluminescence to its narrow edges where they are converted by photovoltaic cells. Unfortunately, LSCs have suffered from numerous efficiency losses. Therefore, new luminescent species and novel approaches are needed for its practical application. This paper deals with investigation of nonhazardous, environmental friendly luminescent species include CuInS2/ZnS core/shell QDs. The CuInS2/ZnS QDs possess advantages of Stocks shift as large as more than 130 nm and high photoluminescence quantum yield of 80%. The paper presents the effect of large stock shift CuInS2/ZnS QDs on reducing the reabsorption losses in LSC by using experimental investigation. The LSC sheets were fabricated by dispersing CuInS2/ZnS QDs particles in a polymethylmethacrylate waveguide. A series of LSCs (dimension 4.0 cm × 3.0 cm × 0.3cm) with different CuInS2/ZnS QDs particles concentration (0.015 and 0.03 wt.%) were fabricated and their optical properties (absorptions/emissions) were characterized. The results show that the CuInS2/ZnS QDs-LSC provides a promising way for the reduction of reabsorption losses in LSCs.

Simultaneous NOx and hydrocarbon emissions control for lean-burn engines using low-temperature solid oxide fuel cell at open circuit.

PubMed

Huang, Ta-Jen; Hsu, Sheng-Hsiang; Wu, Chung-Ying

2012-02-21

The high fuel efficiency of lean-burn engines is associated with high temperature and excess oxygen during combustion and thus is associated with high-concentration NO(x) emission. This work reveals that very high concentration of NO(x) in the exhaust can be reduced and hydrocarbons (HCs) can be simultaneously oxidized using a low-temperature solid oxide fuel cell (SOFC). An SOFC unit is constructed with Ni-YSZ as the anode, YSZ as the electrolyte, and La(0.6)Sr(0.4)CoO(3) (LSC)-Ce(0.9)Gd(0.1)O(1.95) as the cathode, with or without adding vanadium to LSC. SOFC operation at 450 °C and open circuit can effectively treat NO(x) over the cathode at a very high concentration in the simulated exhaust. Higher NO(x) concentration up to 5000 ppm can result in a larger NO(x) to N(2) rate. Moreover, a higher oxygen concentration promotes NO conversion. Complete oxidation of HCs can be achieved by adding silver to the LSC current collecting layer. The SOFC-based emissions control system can treat NO(x) and HCs simultaneously, and can be operated without consuming the anode fuel (a reductant) at near the engine exhaust temperature to eliminate the need for reductant refilling and extra heating.

Scale-up of a Luminescent Solar Concentrator-Based Photomicroreactor via Numbering-up

PubMed Central

2017-01-01

The use of solar energy to power chemical reactions is a long-standing dream of the chemical community. Recently, visible-light-mediated photoredox catalysis has been recognized as the ideal catalytic transformation to convert solar energy into chemical bonds. However, scaling photochemical transformations has been extremely challenging due to Bouguer–Lambert–Beer law. Recently, we have pioneered the development of luminescent solar concentrator photomicroreactors (LSC-PMs), which display an excellent energy efficiency. These devices harvest solar energy, convert the broad solar energy spectrum to a narrow-wavelength region, and subsequently waveguide the re-emitted photons to the reaction channels. Herein, we report on the scalability of such LSC-PMs via a numbering-up strategy. Paramount in our work was the use of molds that were fabricated via 3D printing. This allowed us to rapidly produce many different prototypes and to optimize experimentally key design aspects in a time-efficient fashion. Reactors up to 32 parallel channels have been fabricated that display an excellent flow distribution using a bifurcated flow distributor (standard deviations below 10%). This excellent flow distribution was crucial to scale up a model reaction efficiently, displaying yields comparable to those obtained in a single-channel device. We also found that interchannel spacing is an important and unique design parameter for numbered-up LSC-PMs, which influences greatly the photon flux experienced within the reaction channels. PMID:29333350

The impact of robotics on practice management of endometrial cancer: transitioning from traditional surgery.

PubMed

Hoekstra, Anna V; Jairam-Thodla, Arati; Rademaker, Alfred; Singh, Diljeet K; Buttin, Barbara M; Lurain, John R; Schink, Julian C; Lowe, M Patrick

2009-12-01

Evaluation of the impact of a new robotic surgery programme on perioperative outcomes for endometrial cancer A prospective database of all patients undergoing staging for endometrial cancer during July 2007-July 2008 was collected and analysed. Demographic data and perioperative outcomes were compared between cases performed via laparotomy, laparoscopy and robotics. Sixty-five patients underwent staging during the time of data collection (LAP-26, LSC-7, ROB-32). No difference in surgical volume in the year before vs. after robotics was identified. Median operative time for robotics and laparotomy was significantly less than for laparoscopy (p = 0.023). There was no significant difference in lymph node yields between the three groups (p = 0.92). Robotics was associated with significantly less blood loss (p < 0.0001). Complication rates were significantly lower in the robotic group compared to the laparotomy group (p = 0.05). Median hospital stay was 1 day for the minimally invasive groups. Total number of perioperative inpatient days decreased from 331 to 150 in one year. Practice management of endometrial cancer transitioned from a predominantly open approach (5.6% LSC) to robotics (11% LSC, 49% ROB) within 12 months. Robotic surgery dramatically altered our management of endometrial cancer and was associated with a significant improvement in several perioperative outcomes when compared to laparotomy and laparoscopy. Copyright (c) 2009 John Wiley & Sons, Ltd.

24 CFR 905.120 - Penalties for slow obligation or expenditure of Capital Fund program assistance.

Code of Federal Regulations, 2011 CFR

2011-04-01

... expenditure of Capital Fund program assistance. 905.120 Section 905.120 Housing and Urban Development... INDIAN HOUSING, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT THE PUBLIC HOUSING CAPITAL FUND PROGRAM Capital Fund § 905.120 Penalties for slow obligation or expenditure of Capital Fund program assistance. In...

45 CFR 2519.600 - How are funds for Higher Education programs distributed?

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 4 2010-10-01 2010-10-01 false How are funds for Higher Education programs...) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE HIGHER EDUCATION INNOVATIVE PROGRAMS FOR COMMUNITY SERVICE Distribution of Funds § 2519.600 How are funds for Higher Education programs distributed? All funds under this...

44 CFR 80.1 - Purpose and scope.

Code of Federal Regulations, 2014 CFR

2014-10-01

... date, applicable program regulations and guidance in effect for the funding program (available at http... requirements of the funding grant program and must be read in conjunction with the relevant program regulations... oversight, applies to projects for which the funding program application period opens or for which funding...

44 CFR 80.1 - Purpose and scope.

Code of Federal Regulations, 2012 CFR

2012-10-01

... date, applicable program regulations and guidance in effect for the funding program (available at http... requirements of the funding grant program and must be read in conjunction with the relevant program regulations... oversight, applies to projects for which the funding program application period opens or for which funding...

44 CFR 80.1 - Purpose and scope.

Code of Federal Regulations, 2011 CFR

2011-10-01

... date, applicable program regulations and guidance in effect for the funding program (available at http... requirements of the funding grant program and must be read in conjunction with the relevant program regulations... oversight, applies to projects for which the funding program application period opens or for which funding...

44 CFR 80.1 - Purpose and scope.

Code of Federal Regulations, 2013 CFR

2013-10-01

... date, applicable program regulations and guidance in effect for the funding program (available at http... requirements of the funding grant program and must be read in conjunction with the relevant program regulations... oversight, applies to projects for which the funding program application period opens or for which funding...

77 FR 13530 - Funding for the Conservation Loan Program; Farm Loan Programs

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-07

... DEPARTMENT OF AGRICULTURE Farm Service Agency Funding for the Conservation Loan Program; Farm Loan... Service Agency (FSA) now has funding for and is accepting guaranteed loan applications for the Conservation Loan (CL) Program. Due to a lack of program funding for direct CLs, direct loan applications are...

Microenvironment Determines Lineage Fate in a Human Model of MLL-AF9 Leukemia

PubMed Central

Wei, Junping; Wunderlich, Mark; Fox, Catherine; Alvarez, Sara; Cigudosa, Juan C.; Wilhelm, Jamie S.; Zheng, Yi; Cancelas, Jose A.; Gu, Yi; Jansen, Michael; DiMartino, Jorge F.; Mulloy, James C.

2008-01-01

Summary Faithful modeling of mixed lineage leukemia in murine cells has been difficult to achieve. We show that expression of MLL-AF9 in human CD34+ cells induces acute myeloid, lymphoid or mixed lineage leukemia in immunodeficient mice. Some leukemia stem cells (LSC) were multipotent and could be lineage directed by altering either the growth factors or the recipient strain of mouse, highlighting the importance of microenviromental cues. Other LSC were strictly lineage committed, demonstrating the heterogeneity of the stem cell compartment in MLL disease. Targeting the Rac signaling pathway by pharmacologic or genetic means resulted in rapid and specific apoptosis of MLL-AF9 cells, suggesting that the Rac signaling pathway may be a valid therapeutic target in MLL-rearranged AML. PMID:18538732

Properties of Blazar Jets Defined by an Economy of Power

NASA Astrophysics Data System (ADS)

Petropoulou, Maria; Dermer, Charles D.

2016-07-01

The absolute power of a relativistic black hole jet includes the power in the magnetic field, the leptons, the hadrons, and the radiated photons. A power analysis of a relativistic radio/γ-ray blazar jet leads to bifurcated leptonic synchrotron-Compton (LSC) and leptohadronic synchrotron (LHS) solutions that minimize the total jet power. Higher Doppler factors with increasing peak synchrotron frequency are implied in the LSC model. Strong magnetic fields {B}\\prime ≳ 100 {{G}} are found for the LHS model with variability times ≲ {10}3 {{s}}, in accord with highly magnetized, reconnection-driven jet models. Proton synchrotron models of ≳ 100 {GeV} blazar radiation can have sub-Eddington absolute jet powers, but models of dominant GeV radiation in flat spectrum radio quasars require excessive power.

MX Siting Investigation. Water Resources Program. Volume II. Review Draft, Water Appropriations Hearing Presentation and Support Documentation, Dry Lake Valley, Nevada.

DTIC Science & Technology

1981-09-30

will be required to de - liver the 651 gpm (41 l/s) needed for peak water use at the LSC. The existing Air Force test well at 3S-64E-12ca has been pumped...Valley is probably over 10,000 feet (3048 m) thick in the central part of the valley and is composed of alluvial fan, fluvial, playa , srl lacustrine...VALLEY T3.NSmIP STATION T E𔃾P SP. or SS. SILICA C AL C IU4 ACG. E5SILJ4 SCDIU I QANSA-SECT 5 6 C1 Ŕ VQ %;,. DES C CONE PH SOLIDS (5102) CA V$ A% 1 IN/6

25 CFR 39.130 - Can ISEF funds be used for Language Development Programs?

Code of Federal Regulations, 2010 CFR

2010-04-01

... INDIAN SCHOOL EQUALIZATION PROGRAM Indian School Equalization Formula Language Development Programs § 39.130 Can ISEF funds be used for Language Development Programs? Yes, schools can use ISEF funds to... 25 Indians 1 2010-04-01 2010-04-01 false Can ISEF funds be used for Language Development Programs...

76 FR 52006 - Announcement of Funding Awards for the Assisted Living Conversion Program; Fiscal Year 2009

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-19

... Awards for the Assisted Living Conversion Program; Fiscal Year 2009 AGENCY: Office of the Assistant... funding under the Notice of Funding Availability (NOFA) for the Assisted Living Conversion Program (ALCP... for this program is 14.314. The Assisted Living Conversion Program is designed to provide funds to...

78 FR 28606 - Announcement of Funding Awards for the Assisted Living Conversion Program Fiscal Year 2012

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-15

... Awards for the Assisted Living Conversion Program Fiscal Year 2012 AGENCY: Office of the Assistant... funding under the Notice of Funding Availability (NOFA) for the Assisted Living Conversion Program (ALCP... for this program is 14.314. The Assisted Living Conversion Program is designed to provide funds to...

25 CFR 39.130 - Can ISEF funds be used for Language Development Programs?

Code of Federal Regulations, 2011 CFR

2011-04-01

... 25 Indians 1 2011-04-01 2011-04-01 false Can ISEF funds be used for Language Development Programs... INDIAN SCHOOL EQUALIZATION PROGRAM Indian School Equalization Formula Language Development Programs § 39.130 Can ISEF funds be used for Language Development Programs? Yes, schools can use ISEF funds to...

Federal Funding for Health Security in FY2018.

PubMed

Watson, Crystal; Watson, Matthew; Kirk Sell, Tara

This article is the latest in an annual series analyzing federal funding for health security programs. It examines proposed funding in the President's Budget Request for FY2018 and provides updated amounts for FY2017 and actual funding for FY2010 through FY2016. The proposed FY2018 budget for health security-related programs represents a significant decrease in funding from prior years and previous administrations. In total, the President's proposed FY2018 budget includes $12.45 billion for health security-related programs, an estimated decrease in funding of $1.25 billion, or 9%, from the estimated $13.71 billion in FY2017 and an 11% decrease from the FY2016 actual funding level of $13.99 billion. Most FY2018 health security funding ($6.67 billion, 54%) would go to programs with multiple-hazard and preparedness goals and missions, representing a 14% decrease in this funding compared to FY2017. Radiological and nuclear security programs would receive 20% ($2.48 billion) of all health security funding, a slight decrease of 2% from the prior year. Biosecurity programs would be funded at $1.53 billion (12% of health security funding) in FY2018, a decrease of 6% compared to FY2017. Chemical security programs would represent 3% ($389.7 million) of all health security funding in FY2018, a 9% decrease from the prior year. Finally, 11% of health security funding ($1.39 billion) would be dedicated to pandemic influenza and emerging infectious diseases programs, the only category of funding to see an increase (3%) above FY2017.

28 CFR 92.12 - Program funding length.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 28 Judicial Administration 2 2011-07-01 2011-07-01 false Program funding length. 92.12 Section 92.12 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) OFFICE OF COMMUNITY ORIENTED POLICING SERVICES (COPS) Police Recruitment Program Guidelines § 92.12 Program funding length. Funding for these...

28 CFR 92.12 - Program funding length.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 28 Judicial Administration 2 2014-07-01 2014-07-01 false Program funding length. 92.12 Section 92.12 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) OFFICE OF COMMUNITY ORIENTED POLICING SERVICES (COPS) Police Recruitment Program Guidelines § 92.12 Program funding length. Funding for these...

28 CFR 92.12 - Program funding length.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Program funding length. 92.12 Section 92.12 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) OFFICE OF COMMUNITY ORIENTED POLICING SERVICES (COPS) Police Recruitment Program Guidelines § 92.12 Program funding length. Funding for these...

28 CFR 92.12 - Program funding length.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Program funding length. 92.12 Section 92.12 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) OFFICE OF COMMUNITY ORIENTED POLICING SERVICES (COPS) Police Recruitment Program Guidelines § 92.12 Program funding length. Funding for these...

28 CFR 92.12 - Program funding length.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Program funding length. 92.12 Section 92.12 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) OFFICE OF COMMUNITY ORIENTED POLICING SERVICES (COPS) Police Recruitment Program Guidelines § 92.12 Program funding length. Funding for these...

7 CFR 761.211 - Transfer of funds.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 7 2011-01-01 2011-01-01 false Transfer of funds. 761.211 Section 761.211 Agriculture... SPECIAL PROGRAMS GENERAL PROGRAM ADMINISTRATION Allocation of Farm Loan Programs Funds to State Offices § 761.211 Transfer of funds. If sufficient unsubsidized guaranteed OL funds are available, then...

7 CFR 761.210 - Transfer of funds.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 7 2010-01-01 2010-01-01 false Transfer of funds. 761.210 Section 761.210 Agriculture... SPECIAL PROGRAMS GENERAL PROGRAM ADMINISTRATION Allocation of Farm Loan Programs Funds to State Offices § 761.210 Transfer of funds. If sufficient unsubsidized guaranteed OL funds are available, then...

The financial health of global health programs.

PubMed

Liaw, Winston; Bazemore, Andrew; Mishori, Ranit; Diller, Philip; Bardella, Inis; Chang, Newton

2014-10-01

No studies have examined how established global health (GH) programs have achieved sustainability. The objective of this study was to describe the financial status of GH programs. In this cross-sectional survey of the Society of Teachers of Family Medicine's Group on Global Health, we assessed each program's affiliation, years of GH activities, whether or not participation was formalized, time spent on GH, funding, and anticipated funding. We received 31 responses (30% response rate); 55% were affiliated with residencies, 29% were affiliated with medical schools, 16% were affiliated with both, and 68% had formalized programs. Respondents spent 19% full-time equivalent (FTE) on GH and used a mean of 3.3 funding sources to support GH. Given a mean budget of $28,756, parent institutions provided 50% while 15% was from personal funds. Twenty-six percent thought their funding would increase in the next 2 years. Compared to residencies, medical school respondents devoted more time (26% FTE versus 13% FTE), used more funding categories (4.7 versus 2.2), and anticipated funding increases (42.8% versus 12.0%). Compared to younger programs (? 5 years), respondents from older programs (> 5 years) devoted more time (25% FTE versus 16% FTE) and used more funding categories (3.8 versus 2.9). Compared to those lacking formal programs, respondents from formalized programs were less likely to use personal funds (19% versus 60%). This limited descriptive study offers insight into the financial status of GH programs. Despite institutional support, respondents relied on personal funds and were pessimistic about future funding.

45 CFR 287.45 - How can NEW Program funds be used?

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 2 2010-10-01 2010-10-01 false How can NEW Program funds be used? 287.45 Section 287.45 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY ASSISTANCE (ASSISTANCE... EMPLOYMENT WORKS (NEW) PROGRAM NEW Program Funding § 287.45 How can NEW Program funds be used? (a) NEW grants...

45 CFR 1614.1 - Purpose.

Code of Federal Regulations, 2010 CFR

2010-10-01

... and one-half percent (121/2%) of the recipient's LSC annualized basic field award to the involvement... in a manner which is generally open to broad participation in those activities undertaken with those...

Response of bone turnover markers to raloxifene treatment in postmenopausal women with osteopenia.

PubMed

Naylor, K E; Jacques, R M; Peel, N F A; Gossiel, F; Eastell, R

2016-08-01

We used two methods of identifying women who reached the target for raloxifene treatment with bone turnover markers. Both approaches identified women that responded to treatment but did not fully agree and may be complementary. The change in bone turnover markers (BTMs) in response to osteoporosis therapy can be assessed by a decrease beyond the least significant change (LSC) or below the mean of the reference interval (RI). We compared the performance of these two approaches in women treated with raloxifene. Fifty postmenopausal osteopenic women (age 51-72 years) were randomised to raloxifene or no treatment for 2 years. Blood samples were collected for the measurement of BTM. The LSC for each marker was calculated from the untreated women and the RI obtained from healthy premenopausal women (age 35-40 years). Bone mineral density (BMD) was measured at the spine and hip. There was a decrease in BTM in response to raloxifene treatment, percentage change at 12 weeks: C terminal telopeptide of type I collagen (CTX) -39 % (95 % CI -48 to -28) and N terminal propeptide of type I procollagen (PINP) -32 % (95 % CI -40 to -23) P < 0.001. The proportion of women classified as responding to treatment using LSC at 12 weeks was as follows: CTX 38 % and PINP 52 % and at 48 weeks CTX 60 % and PINP 65 %. For the RI approach, the proportion of women classified as responding to treatment at 12 weeks was CTX and PINP 38 % and at 48 weeks CTX 40 % and PINP 45 %. There was a significant difference in the change in spine BMD in the raloxifene-treated group compared to the no-treatment group at week 48: difference 0.031 g/cm(2) (95 % CI 0.016 to 0.046, P < 0.001). The two approaches identified women that reached the target for treatment using BTM. Both LSC and RI criteria appear useful in identifying treatment response, but the two approaches do not fully overlap and may be complementary.

7 CFR 1783.1 - What is the purpose of the Revolving Fund Program?

Code of Federal Regulations, 2010 CFR

2010-01-01

... UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE (CONTINUED) REVOLVING FUNDS FOR FINANCING WATER AND WASTEWATER PROJECTS (REVOLVING FUND PROGRAM) General § 1783.1 What is the purpose of the Revolving Fund Program? This... to capitalize revolving funds for the purpose of providing financing to eligible entities for pre...

Low-cost photovoltaics: Luminescent solar concentrators and colloidal quantum dot solar cells

NASA Astrophysics Data System (ADS)

Leow, Shin Woei

Solar energy has long been lauded as an inexhaustible fuel source with more energy reaching the earth's surface in one hour than the global consumption for a year. Although capable of satisfying the world's energy requirements, solar energy remains an expensive technology that has yet to attain grid parity. Another drawback is that existing solar farms require large quantities of land in order to generate power at useful rates. In this work, we look to luminescent solar concentrator systems and quantum dot technology as viable solutions to lowering the cost of solar electricity production with the flexibility to integrate such technologies into buildings to achieve dual land use. Luminescent solar concentrator (LSC) windows with front-facing photovoltaic (PV) cells were built and their gain and power efficiency were investigated. Conventional LSCs employ a photovoltaic (PV) cell that is placed on the edge of the LSC, facing inward. This work describes a new design with the PV cells on the front-face allowing them to receive both direct solar irradiation and wave-guided photons emitted from a dye embedded in an acrylic sheet, which is optically coupled to the PV cells. Parameters investigated include the thickness of the waveguide, edge treatment of the window, cell width, and cell placement. The data allowed us to make projections that aided in designing windows for maximized overall efficiency. A gain in power of 2.2x over the PV cells alone was obtained with PV cell coverage of 5%, and a power conversion efficiency as high as 6.8% was obtained with a PV cell coverage of 31%. Balancing the trade-offs between gain and efficiency, the design with the lowest cost per watt attained a power efficiency of 3.8% and a gain of 1.6x. With the viability of the LSC demonstrated, a weighted Monte-Carlo Ray Tracing program was developed to study the transport of photons and loss mechanisms in the LSC to aid in design optimization. The program imports measured absorption/emission spectra of an organic luminescent dye (LR305), the transmission coefficient and refractive index of acrylic as parameters that describe the system. Simulations suggest that for LR305, 8-10cm of luminescent material surrounding the PV cell yields the highest increase in power gain per unit area of LSC added, thereby determining the ideal spacing between PV cells in the panel. The model also predicts that for different PV cell dimensions, there exists an optimum waveguide thickness which efficiently transports photon collected by the waveguide to the PV cell with minimal loss, and maintains an even distribution of photons across the cell surface. For the case of the 12.5 by 1cm rectangular cells used in this work, the calculated waveguide thickness is 3mm. For larger cells, every 1cm increment in PV cell width should be accompanied by a 0.75mm increase in waveguide thickness to preserve peak performance. In line with the goal of pushing for cost competitive photovoltaics, the last part of this work shifts to the study of colloidal quantum dot solar cells. A combination of low temperature, highly scalable fabrication process and reduced material usage for thin films offers us a means to produce flexible and cheap solar cells. Tagging on to existing work already performed on germanium quantum dot solar cells, additional work was carried out to further characterize the material. The effect of film thickness, nano-particle surface conditions and thermal anneal were investigated. There is evidence to suggest that the quantum dot devices contain high levels of parasitic resistances. Short circuit current densities increase by up to two times with two spin-cast layers compared to four, leading to the conjecture that charge carrier life time is low with high levels of recombination. Annealing to improve carrier mobility produces devices with current densities up to 301microA, a fourfold increase, but output voltages saw a sharp decrease from 0.12V to 0.015V. In tandem with the work on germanium, experiments on silicon quantum dots were also carried out to investigate their viability for use as photovoltaic devices. The stronger bonds formed by silicon hindered the ligand exchange process. Schottky diodes were made via drop casting and displayed a clear photovoltaic effect albeit with very low current densities. Interestingly, an open circuit voltage was observed even when not under illumination and further investigations are ongoing.

Successful Community College Fund-Raising Programs

ERIC Educational Resources Information Center

Anderson, Spencer

2005-01-01

This article describes a study whose primary purposes were to determine the characteristics of an effective fund-raising program, the marketing practices that contribute to the success of a fund-raising program, and factors of the development system's influence on a fund-raising program. This study utilized a Delphi research instrument. Initially,…

13 CFR 400.209 - Funding for the Program.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Funding for the Program. 400.209 Section 400.209 Business Credit and Assistance EMERGENCY STEEL GUARANTEE LOAN BOARD EMERGENCY STEEL GUARANTEE LOAN PROGRAM Steel Guarantee Loans § 400.209 Funding for the Program. The Act provides funding for...

13 CFR 400.209 - Funding for the Program.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 13 Business Credit and Assistance 1 2012-01-01 2012-01-01 false Funding for the Program. 400.209 Section 400.209 Business Credit and Assistance EMERGENCY STEEL GUARANTEE LOAN BOARD EMERGENCY STEEL GUARANTEE LOAN PROGRAM Steel Guarantee Loans § 400.209 Funding for the Program. The Act provides funding for...

13 CFR 400.209 - Funding for the Program.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 13 Business Credit and Assistance 1 2013-01-01 2013-01-01 false Funding for the Program. 400.209 Section 400.209 Business Credit and Assistance EMERGENCY STEEL GUARANTEE LOAN BOARD EMERGENCY STEEL GUARANTEE LOAN PROGRAM Steel Guarantee Loans § 400.209 Funding for the Program. The Act provides funding for...

13 CFR 400.209 - Funding for the Program.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 13 Business Credit and Assistance 1 2014-01-01 2014-01-01 false Funding for the Program. 400.209 Section 400.209 Business Credit and Assistance EMERGENCY STEEL GUARANTEE LOAN BOARD EMERGENCY STEEL GUARANTEE LOAN PROGRAM Steel Guarantee Loans § 400.209 Funding for the Program. The Act provides funding for...

13 CFR 400.209 - Funding for the Program.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 13 Business Credit and Assistance 1 2011-01-01 2011-01-01 false Funding for the Program. 400.209 Section 400.209 Business Credit and Assistance EMERGENCY STEEL GUARANTEE LOAN BOARD EMERGENCY STEEL GUARANTEE LOAN PROGRAM Steel Guarantee Loans § 400.209 Funding for the Program. The Act provides funding for...

45 CFR 1641.7 - Causes for debarment.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., SUSPENSION AND REMOVAL OF RECIPIENT AUDITORS Debarment § 1641.7 Causes for debarment. The debarring official... Recipients and Auditors, including the Compliance Supplement for Audits of LSC Recipients, and in OIG Audit...

45 CFR 1641.7 - Causes for debarment.

Code of Federal Regulations, 2011 CFR

2011-10-01

..., SUSPENSION AND REMOVAL OF RECIPIENT AUDITORS Debarment § 1641.7 Causes for debarment. The debarring official... Recipients and Auditors, including the Compliance Supplement for Audits of LSC Recipients, and in OIG Audit...

20 CFR 652.205 - May funds authorized under the Act be used to supplement funding for labor exchange programs...

Code of Federal Regulations, 2010 CFR

2010-04-01

... supplement funding for labor exchange programs authorized under separate legislation? 652.205 Section 652.205... § 652.205 May funds authorized under the Act be used to supplement funding for labor exchange programs... under sections 7(a) or 7(b) of the Act to supplement funding of any workforce activity carried out under...

49 CFR 268.5 - Federal funding sources for the Maglev Deployment Program.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 4 2014-10-01 2014-10-01 false Federal funding sources for the Maglev Deployment... TECHNOLOGY DEPLOYMENT PROGRAM Overview § 268.5 Federal funding sources for the Maglev Deployment Program. (a) Federal Maglev Funds. Section 322 of Title 23 provides for the following funds for the Maglev Deployment...

49 CFR 268.5 - Federal funding sources for the Maglev Deployment Program.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 4 2012-10-01 2012-10-01 false Federal funding sources for the Maglev Deployment... TECHNOLOGY DEPLOYMENT PROGRAM Overview § 268.5 Federal funding sources for the Maglev Deployment Program. (a) Federal Maglev Funds. Section 322 of Title 23 provides for the following funds for the Maglev Deployment...

49 CFR 268.5 - Federal funding sources for the Maglev Deployment Program.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 4 2013-10-01 2013-10-01 false Federal funding sources for the Maglev Deployment... TECHNOLOGY DEPLOYMENT PROGRAM Overview § 268.5 Federal funding sources for the Maglev Deployment Program. (a) Federal Maglev Funds. Section 322 of Title 23 provides for the following funds for the Maglev Deployment...

49 CFR 268.5 - Federal funding sources for the Maglev Deployment Program.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 4 2011-10-01 2011-10-01 false Federal funding sources for the Maglev Deployment... TECHNOLOGY DEPLOYMENT PROGRAM Overview § 268.5 Federal funding sources for the Maglev Deployment Program. (a) Federal Maglev Funds. Section 322 of Title 23 provides for the following funds for the Maglev Deployment...

48 CFR 2110.7002 - Contractor investment of FEGLI Program funds.

Code of Federal Regulations, 2010 CFR

2010-10-01

... FEGLI Program funds. 2110.7002 Section 2110.7002 Federal Acquisition Regulations System OFFICE OF... Contractor investment of FEGLI Program funds. (a) The Contractor is required to invest and reinvest all FEGLI Program funds on hand, including any attributable to the special contingency reserve (as used in 5 U.S.C...

30 CFR 736.24 - Federal program effect on State funding.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 30 Mineral Resources 3 2012-07-01 2012-07-01 false Federal program effect on State funding. 736.24... § 736.24 Federal program effect on State funding. (a) After the withdrawal of a State program and the... finds, in writing, that discontinuation of funding would not be consistent with achieving the purposes...

30 CFR 736.24 - Federal program effect on State funding.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Federal program effect on State funding. 736.24... § 736.24 Federal program effect on State funding. (a) After the withdrawal of a State program and the... finds, in writing, that discontinuation of funding would not be consistent with achieving the purposes...

30 CFR 736.24 - Federal program effect on State funding.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 3 2011-07-01 2011-07-01 false Federal program effect on State funding. 736.24... § 736.24 Federal program effect on State funding. (a) After the withdrawal of a State program and the... finds, in writing, that discontinuation of funding would not be consistent with achieving the purposes...

30 CFR 736.24 - Federal program effect on State funding.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 30 Mineral Resources 3 2014-07-01 2014-07-01 false Federal program effect on State funding. 736.24... § 736.24 Federal program effect on State funding. (a) After the withdrawal of a State program and the... finds, in writing, that discontinuation of funding would not be consistent with achieving the purposes...

30 CFR 736.24 - Federal program effect on State funding.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 30 Mineral Resources 3 2013-07-01 2013-07-01 false Federal program effect on State funding. 736.24... § 736.24 Federal program effect on State funding. (a) After the withdrawal of a State program and the... finds, in writing, that discontinuation of funding would not be consistent with achieving the purposes...

78 FR 21610 - Expansion Funds for the Support of the Senior Medicare Patrol (SMP) Program

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-11

... the Support of the Senior Medicare Patrol (SMP) Program ACTION: Notice of intent to provide expansion... funds for the support of the Senior Medicare Patrol (SMP) Program. This additional funding opportunity... program capacity to recruit, train, and support the SMP volunteer network. In addition, this funding...

13 CFR 500.209 - Funding for the Program.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Funding for the Program. 500.209... AND GAS GUARANTEED LOAN PROGRAM Oil and Gas Guaranteed Loans § 500.209 Funding for the Program. The Act provides funding for the costs incurred by the Government as a result of granting Guarantees under...

36 CFR 401.10 - Monument Trust Fund Program.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Monument Trust Fund Program... MONUMENTS AND MEMORIALS § 401.10 Monument Trust Fund Program. Pursuant to the provisions of 36 U.S.C. 2106(d), the Commission operates a Monument Trust Fund Program (MTFP) in countries where there is a Commission...

45 CFR 1641.18 - Causes for removal.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., SUSPENSION AND REMOVAL OF RECIPIENT AUDITORS Removal § 1641.18 Causes for removal. The debarring official may... Recipients and Auditors, including the Compliance Supplement for Audits of LSC Recipients, and in OIG Audit...

Characterization of the Canfranc Underground Laboratory:. Status and Future Plans

NASA Astrophysics Data System (ADS)

Luzón, G.; Carmona, J. M.; Cebrián, S.; Iguaz, F.; Irastorza, I. G.; Gómez, H.; Morales, J.; Ortiz de Solórzano, A.; Rodríguez, A.; Ruz, J.; Tomás, A.; Villar, J. A.

2007-08-01

The new Laboratorio Subterráneo de Canfranc (LSC) was inaugurated on March 2006. We report the first measurements of radon concentration, gamma background and muon fluxes performed in the Laboratory.

45 CFR 1641.18 - Causes for removal.

Code of Federal Regulations, 2011 CFR

2011-10-01

..., SUSPENSION AND REMOVAL OF RECIPIENT AUDITORS Removal § 1641.18 Causes for removal. The debarring official may... Recipients and Auditors, including the Compliance Supplement for Audits of LSC Recipients, and in OIG Audit...

Profile modification computations for LHCD experiments on PBX-M using the TSC/LSC model

NASA Astrophysics Data System (ADS)

Kaita, R.; Ignat, D. W.; Jardin, S. C.; Okabayashi, M.; Sun, Y. C.

1996-02-01

The TSC-LSC computational model of the dynamics of lower hybrid current drive has been exercised extensively in comparison with data from a Princeton Beta Experiment-Modification (PBX-M) discharge where the measured q(0) attained values slightly above unity. Several significant, but plausible, assumptions had to be introduced to keep the computation from behaving pathologically over time, producing singular profiles of plasma current density and q. Addition of a heuristic current diffusion estimate, or more exactly, a smoothing of the rf-driven current with a diffusion-like equation, greatly improved the behavior of the computation, and brought theory and measurement into reasonable agreement. The model was then extended to longer pulse lengths and higher powers to investigate performance to be expected in future PBX-M current profile modification experiments.

Plasma Display at the Liberty Science Center

NASA Astrophysics Data System (ADS)

Bruder, Dan; Gilligan, Nick; Tarman, Lisa; Ferris, Pamella; Morgan, James; Delooper, John; Zwicker, Andrew

2009-11-01

The Liberty Science Center (LSC) is the largest (300,000 sq. ft.) education resource in the New Jersey -- New York City region. PPPL in collaboration with the LSC has had a display at the center since 2007 More than 1.5 million visitors have come to the museum since the plasma display has been introduced. The plasma display has had significant use during that time frame. During the summer of 2009 a redesigned plasma exhibit was created by a student teacher-team using the lessons learned from the existing exhibit. The display includes a DC glow discharge tube with a permanent external magnet allowing visitors to manipulate the plasma and see how plasma can be used for fusion research. The goal of the display is to allow an individual to see a plasma and understand the potential benefits of fusion energy.

Production flush of Agaricus blazei on Brazilian casing layers

PubMed Central

Colauto, Nelson Barros; da Silveira, Adriano Reis; da Eira, Augusto Ferreira; Linde, Giani Andrea

2011-01-01

This study aimed to verify the biological efficiency and production flushes of Agaricus blazei strains on different casing layers during 90 cultivation days. Four casing layers were used: mixture of subsoil and charcoal (VCS), lime schist (LSC), São Paulo peat (SPP) and Santa Catarina peat (SCP); and two genetically distant A. blazei strains. The fungus was grown in composted substratum and, after total colonization, a pasteurized casing layer was added over the substratum, and fructification was induced. Mushrooms were picked up daily when the basidiocarp veil was stretched, but before the lamella were exposed. The biological efficiency (BE) was determined by the fresh basidiocarp mass divided by the substratum dry mass, expressed in percentage. The production flushes were also determined over time production. The BE and production flushes during 90 days were affected by the strains as well as by the casing layers. The ABL26 and LSC produced the best BE of 60.4%. Although VCS is the most used casing layer in Brazil, it is inferior to other casing layers, for all strains, throughout cultivation time. The strain, not the casing layer, is responsible for eventual variations of the average mushroom mass. In average, circa 50% of the mushroom production occurs around the first month, 30% in the second month, and 20% in third month. The casing layer water management depends on the casing layer type and the strain. Production flush responds better to water reposition, mainly with ABL26, and better porosity to LSC and SCP casing layers. PMID:24031673

The crystal structure of Erwinia amylovora levansucrase provides a snapshot of the products of sucrose hydrolysis trapped into the active site.

PubMed

Wuerges, Jochen; Caputi, Lorenzo; Cianci, Michele; Boivin, Stephane; Meijers, Rob; Benini, Stefano

2015-09-01

Levansucrases are members of the glycoside hydrolase family and catalyse both the hydrolysis of the substrate sucrose and the transfer of fructosyl units to acceptor molecules. In the presence of sufficient sucrose, this may either lead to the production of fructooligosaccharides or fructose polymers. Aim of this study is to rationalise the differences in the polymerisation properties of bacterial levansucrases and in particular to identify structural features that determine different product spectrum in the levansucrase of the Gram-negative bacterium Erwinia amylovora (Ea Lsc, EC 2.4.1.10) as compared to Gram-positive bacteria such as Bacillus subtilis levansucrase. Ea is an enterobacterial pathogen responsible for the Fire Blight disease in rosaceous plants (e.g., apple and pear) with considerable interest for the agricultural industry. The crystal structure of Ea Lsc was solved at 2.77 Å resolution and compared to those of other fructosyltransferases from Gram-positive and Gram-negative bacteria. We propose the structural features, determining the different reaction products, to reside in just a few loops at the rim of the active site funnel. Moreover we propose that loop 8 may have a role in product length determination in Gluconacetobacter diazotrophicus LsdA and Microbacterium saccharophilum FFase. The Ea Lsc structure shows for the first time the products of sucrose hydrolysis still bound in the active site. Copyright © 2015 Elsevier Inc. All rights reserved.

Chromatin texture, DNA index, and S-phase fraction in primary breast carcinoma cells analysed by laserscanning cytometry.

PubMed

Kuliffay, P; Sanislo, L; Galbavy, S

2010-01-01

Laser scanning cytometry (LSC) is a slide-based technique capable of measuring a number of biological parameters both in immobilised cell suspensions and in formalin-fixed paraffin-embedded tissue sections. High proliferation rate in surgically removed breast tumours is an unfavourable prognostic factor. In node negative cases it can help distinguish patients with higher risk for distant metastases from those with a lower risk. In a prospective study we investigated 140 breast tumours, of which 113 were invasive ductal carcinomas, 11 were invasive lobular carcinomas, and 16 tumours were of other histological types. Cells for LSC investigations were prepared from fresh, surgically removed tumours by mechanical disintegration. After fixation the cells were stained with FITC-conjugated anti-cytokeratin (CK-FITC) to distinguish CK+ tumour cells from CK- stroma, and with propidium iodide to stain DNA. We identified three S-phase fraction (SPF) groups, with low (30 patients), moderate (54 patients), and high SPF (51 patients). Thirty-seven tumours were diploid, 83 were aneuploid, while 5 tumours had a bimodal distribution of DNA content. Chromatin texture values were increasing in the respective subclasses from the hypodiploid group to the tetraploid/hypertetraploid group. The measurement of DNA content and SPF of tumours by LSC completed by and correlated with other biological properties of the tumour cells may be a useful tool in assessing prognosis and clinical outcome of patients with breast cancer. (Tab. 5, Fig. 4, Ref. 18). Full Text (Free, PDF) www.bmj.sk.

Women's rights, the family, and organisational culture: a Lesotho case study.

PubMed

Everett, E

1997-02-01

Traditional cultural norms have had significant implications for the work and internal structure of Lesotho Save the Children (LSC). From 1964-90, the organization's work focused entirely on the needs of neglected and abandoned boys, for whom it provided residential care. After consultation with the Department of Social Welfare, it was decided to make the residential center a haven for girls as well as boys in need of protection. Many girls in Lesotho experience physical and sexual abuse within their families; moreover, daughters in poor families are often placed in households of wealthier extended family as domestics, where further abuse occurs. Cultural discomfort acknowledging and discussing sexuality extended to Children's Village staff responsible for the care of child rape victims. Coercive sex is often a prelude to marriage in Lesotho, where many women are kidnapped and raped by their prospective bridegrooms. In-service training has enabled staff to overcome their reticence regarding sexual issues and view rape as a criminal act. Although LSC is unable to challenge the oppression of women and children implicit in the traditional family, it continues to encourage girls and women to protest sexual violence, the abuse of their daughters, and the unequal distribution of labor within the family. All children in the LSC residence perform both male- and female-defined duties and attempts are being made to reduce the division of labor among staff in which females are caretakers and males are authority figures.

Does Otosclerosis Affect Dark and Transitional Cells in the Human Vestibular Labyrinth?

PubMed

Kaya, Serdar; Paparella, Michael M; Cureoglu, Sebahattin

2017-02-01

The density of vestibular dark cells (DCs) and vestibular transitional cells (TCs) can be quantitatively decreased in human temporal bones with otosclerosis. Previous reports have shown that otosclerosis can lead to vestibular symptoms. We examined 61 human temporal bone specimens from 52 deceased donors with otosclerosis group-with and without endosteal involvement (EI), and with and without endolymphatic hydrops (EH)-versus 25 specimens from 18 age-matched controls. Using light microscopy, we evaluated the nonsensory epithelium of the lateral semicircular canal (LSC) and posterior semicircular canal (PSC) of the human vestibular labyrinth, focusing on the density of DCs and TCs. In both the LSC and the PSC, as compared with the control group, the mean density of DCs significantly decreased in the EI (+) group, in the EI (+) and EH (+) subgroup, and in the EI (+) and EH (-) subgroup (p < 0.05). In addition, we found a significant difference in the mean density of DCs between the EI (+) group and the EI (-) group in the LSC and in the PSC (p < 0.05). But we found no significant difference in the mean density of TCs in any of the otosclerosis groups or subgroups as compared with the control group (p > 0.05). We found a decrease in the density of DCs associated with EI in human temporal bone specimens with otosclerosis, regardless of the presence of EH. This decrease might cause damage in ion and water transportation, leading to vestibular symptoms.

Does Otosclerosis Affect Dark and Transitional Cells in the Human Vestibular Labyrinth?

PubMed Central

Kaya, Serdar; Paparella, Michael M.; Cureoglu, Sebahattin

2016-01-01

Hypothesis The density of vestibular dark cells (DCs) and vestibular transitional cells (TCs) can be quantitatively decreased in human temporal bones with otosclerosis. Background Previous reports have shown that otosclerosis can lead to vestibular symptoms. Methods We examined 61 human temporal bone specimens from 52 deceased donors with otosclerosis group—with and without endosteal involvement (EI), and with and without endolymphatic hydrops (EH)—vs. 25 specimens from 18 age-matched controls. Using light microscopy, we evaluated the nonsensory epithelium of the lateral semicircular canal (LSC) and posterior semicircular canal (PSC) of the human vestibular labyrinth, focusing on the density of DCs and TCs. Results In both the LSC and the PSC, as compared with the control group, the mean density of DCs significantly decreased in the EI (+) group, in the EI (+) and EH (+) subgroup, and in the EI (+) and EH (−) subgroup (P < 0.05). In addition, we found a significant difference in the mean density of DCs between the EI (+) group and the EI (−) group in the LSC and in the PSC (P < 0.05). But we found no significant difference in the mean density of TCs in any of the otosclerosis groups or subgroups as compared with the control group (P > 0.05). Conclusion We found a decrease in the density of DCs associated with EI in human temporal bone specimens with otosclerosis, regardless of the presence of EH. This decrease might cause damage in ion and water transportation, leading to vestibular symptoms. PMID:27851656

Life after the ban: an assessment of US syringe exchange programs' attitudes about and early experiences with federal funding.

PubMed

Green, Traci C; Martin, Erika G; Bowman, Sarah E; Mann, Marita R; Beletsky, Leo

2012-05-01

We aimed to determine whether syringe exchange programs (SEPs) currently receive or anticipate pursuing federal funding and barriers to funding applications following the recent removal of the long-standing ban on using federal funds for SEPs. We conducted a telephone-administered cross-sectional survey of US SEPs. Descriptive statistics summarized responses; bivariate analyses examined differences in pursuing funding and experiencing barriers by program characteristics. Of the 187 SEPs (92.1%) that responded, 90.9% were legally authorized. Three received federal funds and 116 intended to pursue federal funding. Perceived federal funding barriers were common and included availability and accessibility of funds, legal requirements such as written police support, resource capacity to apply and comply with funding regulations, local political and structural organization, and concern around altering program culture. Programs without legal authorization, health department affiliation, large distribution, or comprehensive planning reported more federal funding barriers. Policy implementation gaps appear to render federal support primarily symbolic. In practice, funding opportunities may not be available to all SEPs. Increased technical assistance and legal reform could improve access to federal funds, especially for SEPs with smaller capacity and tenuous local support.

33 CFR 263.20 - Program funding.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 3 2012-07-01 2012-07-01 false Program funding. 263.20 Section 263.20 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE CONTINUING AUTHORITIES PROGRAMS General § 263.20 Program funding. (a) Program budget. Initial...

33 CFR 263.20 - Program funding.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 3 2013-07-01 2013-07-01 false Program funding. 263.20 Section 263.20 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE CONTINUING AUTHORITIES PROGRAMS General § 263.20 Program funding. (a) Program budget. Initial...

33 CFR 263.20 - Program funding.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 3 2014-07-01 2014-07-01 false Program funding. 263.20 Section 263.20 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE CONTINUING AUTHORITIES PROGRAMS General § 263.20 Program funding. (a) Program budget. Initial...

25 CFR 170.925 - Is ERFO funding supplemental to IRR Program funding?

Code of Federal Regulations, 2010 CFR

2010-04-01

... RESERVATION ROADS PROGRAM Miscellaneous Provisions Emergency Relief § 170.925 Is ERFO funding supplemental to... construction and maintenance funds for FHWA-approved repairs. If IRR construction or maintenance funds are used... used to reimburse the construction or maintenance funds expended. ...

25 CFR 47.11 - Can these funds be used as matching funds for other Federal programs?

Code of Federal Regulations, 2013 CFR

2013-04-01

... EDUCATION UNIFORM DIRECT FUNDING AND SUPPORT FOR BUREAU-OPERATED SCHOOLS § 47.11 Can these funds be used as matching funds for other Federal programs? A Bureau-operated school may use funds that it receives under...

25 CFR 47.11 - Can these funds be used as matching funds for other Federal programs?

Code of Federal Regulations, 2012 CFR

2012-04-01

... EDUCATION UNIFORM DIRECT FUNDING AND SUPPORT FOR BUREAU-OPERATED SCHOOLS § 47.11 Can these funds be used as matching funds for other Federal programs? A Bureau-operated school may use funds that it receives under...

25 CFR 47.11 - Can these funds be used as matching funds for other Federal programs?

Code of Federal Regulations, 2014 CFR

2014-04-01

... EDUCATION UNIFORM DIRECT FUNDING AND SUPPORT FOR BUREAU-OPERATED SCHOOLS § 47.11 Can these funds be used as matching funds for other Federal programs? A Bureau-operated school may use funds that it receives under...

25 CFR 47.11 - Can these funds be used as matching funds for other Federal programs?

Code of Federal Regulations, 2010 CFR

2010-04-01

... EDUCATION UNIFORM DIRECT FUNDING AND SUPPORT FOR BUREAU-OPERATED SCHOOLS § 47.11 Can these funds be used as matching funds for other Federal programs? A Bureau-operated school may use funds that it receives under...

25 CFR 47.11 - Can these funds be used as matching funds for other Federal programs?

Code of Federal Regulations, 2011 CFR

2011-04-01

... EDUCATION UNIFORM DIRECT FUNDING AND SUPPORT FOR BUREAU-OPERATED SCHOOLS § 47.11 Can these funds be used as matching funds for other Federal programs? A Bureau-operated school may use funds that it receives under...

45 CFR 1640.4 - Violation of agreement.

Code of Federal Regulations, 2010 CFR

2010-10-01

... OF FEDERAL LAW TO LSC RECIPIENTS § 1640.4 Violation of agreement. (a) A violation of the agreement... negligence allowed the employee or board member to engage in the activities which led to the conviction or...

76 FR 375 - Notice of Availability: Notice of Funding Availability (NOFA) for HUD's Fiscal Year (FY) 2010...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-04

...: Notice of Funding Availability (NOFA) for HUD's Fiscal Year (FY) 2010 Rural Innovation Fund Program... requirements for HUD's FY 2010 Rural Innovation Fund Program NOFA. Specifically, this NOFA announces the... Innovation grant funds, along with unobligated and unused funds remaining for the Rural Fund's predecessor...

HRSA's PCRE grant recipients' plans for continuation after funding ends.

PubMed

Staff, Thomas J; Burke, Daniel; Engel, Matthew; Loomis, Lucy

2015-01-01

In 2010, the US Department of Health and Human Services, under the Affordable Care Act, appropriated over $167 million to the Health Resources and Services Administration (HRSA) for the Primary Care Residency Expansion (PCRE) program. In 2011, grants from the PCRE program were provided to residency programs in the specialties of family medicine, internal medicine, and pediatrics, allowing them to increase the number of residents in their programs. Seventy-seven programs received grant funding, and 504 primary care resident positions were created. The grants provide 5 years of funding for these positions. There is no provision for federal funding of these positions after 2016. The purpose of this study was to determine the number of residencies that had identified funding that would allow them to continue training these new positions after the PCRE grant period ends. Programs receiving PCRE funding were identified through the HRSA data warehouse website.1 Program directors were surveyed by email between January and March of 2013. A total of 55 programs responded, for a 71.4% response rate. Of those programs, 17.5% had identified funding that would allow them to continue training the increased number of positions beyond 2016. This one-time funding exhibits challenges to sustainability. This information will help inform policy makers that sustainable expansion of primary care graduate medical education (GME) training will require strategies other than time-limited funding mechanisms.

Meeting the National Mandate: Chicago's Government Funded Kindergarten Programs. Evaluation Report--Fiscal 1984.

ERIC Educational Resources Information Center

Chicago Public Schools, IL.

This is a report on government-funded kindergarten programs that were conducted in 1983-84 in more than 110 Chicago schools, most of them in poverty areas. Three funding sources and various instructional models are included in this assessment. The programs differed in format, including half day and all day programs, and in class size. Funds came…

76 FR 13351 - Notice of Funds Availability (NOFA) Inviting Applications for the Biorefinery Assistance Program

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-11

.... Applications must be received by May 10, 2011 to compete for Fiscal Year 2011 program funds. The Notice... 10, 2011, to compete for Fiscal Year 2011 program funds. Any application received after 4:30 p.m... on May 10, 2011, in order to be considered for Fiscal Year 2011 program funds. Any application...

45 CFR 309.135 - What requirements apply to funding, obligating and liquidating Federal title IV-D grant funds?

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 2 2011-10-01 2011-10-01 false What requirements apply to funding, obligating and... (IV-D) PROGRAM Tribal IV-D Program Funding § 309.135 What requirements apply to funding, obligating and liquidating Federal title IV-D grant funds? (a) Funding period—(1) Ongoing funding. Federal title...

45 CFR 309.135 - What requirements apply to funding, obligating and liquidating Federal title IV-D grant funds?

Code of Federal Regulations, 2012 CFR

2012-10-01

... 45 Public Welfare 2 2012-10-01 2012-10-01 false What requirements apply to funding, obligating and... (IV-D) PROGRAM Tribal IV-D Program Funding § 309.135 What requirements apply to funding, obligating and liquidating Federal title IV-D grant funds? (a) Funding period—(1) Ongoing funding. Federal title...

45 CFR 309.135 - What requirements apply to funding, obligating and liquidating Federal title IV-D grant funds?

Code of Federal Regulations, 2014 CFR

2014-10-01

... 45 Public Welfare 2 2014-10-01 2012-10-01 true What requirements apply to funding, obligating and... (IV-D) PROGRAM Tribal IV-D Program Funding § 309.135 What requirements apply to funding, obligating and liquidating Federal title IV-D grant funds? (a) Funding period—(1) Ongoing funding. Federal title...

45 CFR 309.135 - What requirements apply to funding, obligating and liquidating Federal title IV-D grant funds?

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 2 2013-10-01 2012-10-01 true What requirements apply to funding, obligating and... (IV-D) PROGRAM Tribal IV-D Program Funding § 309.135 What requirements apply to funding, obligating and liquidating Federal title IV-D grant funds? (a) Funding period—(1) Ongoing funding. Federal title...

45 CFR 309.135 - What requirements apply to funding, obligating and liquidating Federal title IV-D grant funds?

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 2 2010-10-01 2010-10-01 false What requirements apply to funding, obligating and... (IV-D) PROGRAM Tribal IV-D Program Funding § 309.135 What requirements apply to funding, obligating and liquidating Federal title IV-D grant funds? (a) Funding period—(1) Ongoing funding. Federal title...

31 CFR 205.11 - What requirements apply to funding techniques?

Code of Federal Regulations, 2014 CFR

2014-07-01

... Program Agency must minimize the time elapsing between the transfer of funds from the United States Treasury and the State's payout of funds for Federal assistance program purposes, whether the transfer... EFFICIENT FEDERAL-STATE FUNDS TRANSFERS Rules Applicable to Federal Assistance Programs Included in a...

7 CFR 761.210 - CL funds.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 7 2011-01-01 2011-01-01 false CL funds. 761.210 Section 761.210 Agriculture... SPECIAL PROGRAMS GENERAL PROGRAM ADMINISTRATION Allocation of Farm Loan Programs Funds to State Offices § 761.210 CL funds. (a) The following applicants and conservation projects will receive priority for CL...

31 CFR 103.131 - Customer identification programs for mutual funds.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Finance FINANCIAL RECORDKEEPING AND REPORTING OF CURRENCY AND FOREIGN TRANSACTIONS Anti-Money Laundering Programs Anti-Money Laundering Programs § 103.131 Customer identification programs for mutual funds. (a... mutual fund's anti-money laundering program required under the regulations implementing 31 U.S.C. 5318(h...

Federal funding for health security in FY2015.

PubMed

Boddie, Crystal; Sell, Tara Kirk; Watson, Matthew

2014-01-01

Previous articles in this series have provided funding information for federal civilian biodefense programs and programs focused on radiological and nuclear preparedness and consequence management. This year the authors have expanded the focus of the analysis to US federal funding for health security. This article provides proposed funding amounts for FY2015, estimated amounts for FY2014, and actual amounts for FY2010 through FY2013 in 5 domains critical to health security: biodefense programs, radiological and nuclear programs, chemical programs, pandemic influenza and emerging infectious disease programs, and multiple-hazard and preparedness programs.

78 FR 25755 - Announcement of Funding Awards; Energy Innovation Fund-Multifamily Pilot Program Fiscal Year 2010

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-02

... Awards; Energy Innovation Fund-- Multifamily Pilot Program Fiscal Year 2010 AGENCY: Office of the... funding under the Notice of Funding Availability (NOFA) for the Energy Innovation Fund--Multifamily Pilot.... FOR FURTHER INFORMATION CONTACT: Linda W. Field, Director of Portfolio Management, Office of...

25 CFR 170.136 - How can a tribe obtain funds?

Code of Federal Regulations, 2011 CFR

2011-04-01

... PROGRAM Indian Reservation Roads Program Policy and Eligibility Recreation, Tourism and Trails § 170.136 How can a tribe obtain funds? (a) To receive funding for programs that serve recreation, tourism, and..., including necessary permits. (b) FHWA provides Federal funds to the States for recreation, tourism, and...

25 CFR 170.136 - How can a tribe obtain funds?

Code of Federal Regulations, 2010 CFR

2010-04-01

... PROGRAM Indian Reservation Roads Program Policy and Eligibility Recreation, Tourism and Trails § 170.136 How can a tribe obtain funds? (a) To receive funding for programs that serve recreation, tourism, and..., including necessary permits. (b) FHWA provides Federal funds to the States for recreation, tourism, and...

45 CFR 309.130 - How will Tribal IV-D programs be funded and what forms are required?

Code of Federal Regulations, 2012 CFR

2012-10-01

...-D Program Funding § 309.130 How will Tribal IV-D programs be funded and what forms are required? (a... grants of less than $1 million per 12-month funding period will receive a single annual award. Tribes and Tribal organizations eligible for grants of $1 million or more per 12-month funding period will receive...

45 CFR 309.130 - How will Tribal IV-D programs be funded and what forms are required?

Code of Federal Regulations, 2014 CFR

2014-10-01

...-D Program Funding § 309.130 How will Tribal IV-D programs be funded and what forms are required? (a... grants of less than $1 million per 12-month funding period will receive a single annual award. Tribes and Tribal organizations eligible for grants of $1 million or more per 12-month funding period will receive...

45 CFR 309.130 - How will Tribal IV-D programs be funded and what forms are required?

Code of Federal Regulations, 2010 CFR

2010-10-01

...-D Program Funding § 309.130 How will Tribal IV-D programs be funded and what forms are required? (a... grants of less than $1 million per 12-month funding period will receive a single annual award. Tribes and Tribal organizations eligible for grants of $1 million or more per 12-month funding period will receive...

45 CFR 309.130 - How will Tribal IV-D programs be funded and what forms are required?

Code of Federal Regulations, 2011 CFR

2011-10-01

...-D Program Funding § 309.130 How will Tribal IV-D programs be funded and what forms are required? (a... grants of less than $1 million per 12-month funding period will receive a single annual award. Tribes and Tribal organizations eligible for grants of $1 million or more per 12-month funding period will receive...

45 CFR 309.130 - How will Tribal IV-D programs be funded and what forms are required?

Code of Federal Regulations, 2013 CFR

2013-10-01

...-D Program Funding § 309.130 How will Tribal IV-D programs be funded and what forms are required? (a... grants of less than $1 million per 12-month funding period will receive a single annual award. Tribes and Tribal organizations eligible for grants of $1 million or more per 12-month funding period will receive...

Topographic Map of Pathfinder Landing Site

NASA Technical Reports Server (NTRS)

1997-01-01

Topographic map of the landing site, to a distance of 60 meters from the lander in the LSC coordinate system. The lander is shown schematically in the center; 2.5 meter radius circle (black) centered on the camera was not mapped. Gentle relief [root mean square (rms) elevation variation 0.5 m; rms a directional slope 4O] and organization of topography into northwest and northeast-trending ridges about 20 meters apart are apparent. Roughly 30% of the illustrated area is hidden from the camera behind these ridges. Contours (0.2 m interval) and color coding of elevations were generated from a digital terrain model, which was interpolated by kriging from approximately 700 measured points. Angular and parallax point coordinates were measured manually on a large (5 m length) anaglyphic uncontrolled mosaic and used to calculate Cartesian (LSC) coordinates. Errors in azimuth on the order of 10 are therefore likely; elevation errors were minimized by referencing elevations to the local horizon. The uncertainty in range measurements increases quadratically with range. Given a measurement error of 1/2 pixel, the expected precision in range is 0.3 meter at 10 meter range, and 10 meters at 60 meter range. Repeated measurements were made, compared, and edited for consistency to improve the range precision. Systematic errors undoubtedly remain and will be corrected in future maps compiled digitally from geometrically controlled images. Cartographic processing by U.S. Geological Survey.

NOTE: original caption as published in Science Magazine

Mars Pathfinder is the second in NASA's Discovery program of low-cost spacecraft with highly focused science goals. The Jet Propulsion Laboratory, Pasadena, CA, developed and manages the Mars Pathfinder mission for NASA's Office of Space Science, Washington, D.C. JPL is a division of the California Institute of Technology (Caltech).

Smoking Patterns in Oregon Youth: Effects of Funding and Defunding of a Comprehensive State Tobacco Control Program

PubMed Central

Pizacani, Barbara A.; Dent, Clyde W.; Maher, Julie E.; Rohde, Kristen; Stark, Michael J.; Biglan, Anthony; Thompson, Jill

2014-01-01

Purpose Comprehensive tobacco control programs have included school-based prevention programs as a key strategy to reach adolescents. Unfortunately, these programs have undergone extensive budget reductions in recent years. In 2003, funding for the Oregon Tobacco Prevention and Education Program was reduced by about 70%, and the school component was entirely defunded. To assess the effects of program funding and subsequent defunding on smoking prevalence within targeted Oregon schools, we compared the change in 30-day smoking prevalence between grades 8 and 11 in school districts in two periods: namely, during funding and after funding was eliminated. Methods We used annual school-based survey data for grades 8 and 11 to describe district-level changes in smoking prevalence in five age cohorts: two during the funding period and three after defunding. Each cohort was comprised of districts whose 8th-graders completed the survey and participated again 3 years later. Using mixed models, we compared the change in 30-day adjusted smoking prevalence among cohorts in funded districts, defunded districts, and districts that never received funding. Results Smoking prevalence growth was significantly higher among cohorts from the defunded period than for cohorts from the funded period (p = .04) and was not significantly different from schools that were never-funded (p = .79). Conclusions In Oregon, funding a school component of a comprehensive tobacco control strategy was associated with depressed uptake of smoking. Gains were quickly lost upon program defunding. School programs are an important strategy if they are long term, comprehensive, and reinforced in the larger environment. PMID:19237108

34 CFR 611.41 - Under what circumstances may an individual receive a scholarship of program funds to attend a...

Code of Federal Regulations, 2013 CFR

2013-07-01

... scholarship of program funds to attend a teacher training program? 611.41 Section 611.41 Education Regulations..., DEPARTMENT OF EDUCATION TEACHER QUALITY ENHANCEMENT GRANTS PROGRAM Scholarships § 611.41 Under what circumstances may an individual receive a scholarship of program funds to attend a teacher training program? (a...

34 CFR 611.41 - Under what circumstances may an individual receive a scholarship of program funds to attend a...

Code of Federal Regulations, 2012 CFR

2012-07-01

... scholarship of program funds to attend a teacher training program? 611.41 Section 611.41 Education Regulations..., DEPARTMENT OF EDUCATION TEACHER QUALITY ENHANCEMENT GRANTS PROGRAM Scholarships § 611.41 Under what circumstances may an individual receive a scholarship of program funds to attend a teacher training program? (a...

34 CFR 611.41 - Under what circumstances may an individual receive a scholarship of program funds to attend a...

Code of Federal Regulations, 2014 CFR

2014-07-01

... scholarship of program funds to attend a teacher training program? 611.41 Section 611.41 Education Regulations..., DEPARTMENT OF EDUCATION TEACHER QUALITY ENHANCEMENT GRANTS PROGRAM Scholarships § 611.41 Under what circumstances may an individual receive a scholarship of program funds to attend a teacher training program? (a...

Searching for Correlated Radio Transients & Gravitational Wave Bursts

NASA Astrophysics Data System (ADS)

Kavic, Michael; Shawhan, P. S.; Yancey, C.; Cutchin, S.; Simonetti, J. H.; Bear, B.; Tsai, J.

2013-01-01

We will discuss an ongoing multi-messenger search for transient radio pulses and gravitational wave bursts. This work is being conducted jointly by the Long Wavelength Array (LWA) and the LIGO Scientific Collaboration (LSC). A variety of astrophysical sources can produce simultaneous emission of gravitational waves and coherent low-frequency electromagnetic radiation. The primary common source motivating this work is the merger of neutron star binaries for which the LWA and LSC instruments have comparable sensitivity. Additional common sources include supernovae, long timescale GRBs and cosmic string cusp events. Data taken by both instruments can be compared to search for correlated signals. Identification of correlated signals can be used to increase the sensitivity of both instruments. We will summarize the coincident observations which have already been conducted and outline plans for future work. We will describe the process being used for synthesizing these data set and present preliminary results.

Preparation of paper scintillator for detecting 3H contaminant.

PubMed

Miyoshi, Hirokazu; Ikeda, Toshiji

2013-09-01

Liquid scintillator (LS)-encapsulated silica was prepared by the sol-gel method and then was added dropwise onto a wipe paper to form a paper scintillator. First, the efficiencies of wipe were determined for both the paper scintillator and the wipe paper using a liquid scintillation counter (LSC). The efficiencies of wipe using the paper scintillator and the wipe paper were 88 and 36 %, respectively. The detection efficiencies were 5.5 % for the paper scintillator, 46 % for the wipe paper using an LS and 0.08 % for the (3)H/(14)C survey meter, respectively, compared with that of a melt-on scintillator of 47 %. Second, an (3)H contaminant on the paper scintillator was successfully detected using a photomultiplier without an LSC or an (3)H/(14)C survey meter. Finally, the paper scintillator was able to detect beta rays of the (3)H contaminant easily without an LS.

Characterization of UV fluorophores for application to luminescent solar concentrators

NASA Astrophysics Data System (ADS)

Hellier, Kaitlin; Carter, Sue

The implementation of solar as an alternative energy source faces many challenges, including the competition for space with agriculture and the environmental impacts of solar farms in deserts. As a solution to these problems, the Carter Lab has developed Luminescent Solar Concentrator (LSC) panels for applications to greenhouses. These panels utilize a luminescent dye compatible with the spectrum used in photosynthesis for the plants below and front-facing PV cells, achieving power enhancement of greater than 20% compared with the cells alone. To increase this enhancement, additional portions of the unused spectrum must be harvested. In this talk, we will discuss the characterization of UV absorbing fluorophores, including spectra, quantum yield, and the enhancement of light output and power generation. We will also address the combination of these UV dyes with the original LSC dye in low and high concentration, and the FRET efficiency and potential applications associated with high concentration films.

The Lunar Sample Compendium

NASA Technical Reports Server (NTRS)

Meyer, Charles

2009-01-01

The Lunar Sample Compendium is a succinct summary of the data obtained from 40 years of study of Apollo and Luna samples of the Moon. Basic petrographic, chemical and age information is compiled, sample-by-sample, in the form of an advanced catalog in order to provide a basic description of each sample. The LSC can be found online using Google. The initial allocation of lunar samples was done sparingly, because it was realized that scientific techniques would improve over the years and new questions would be formulated. The LSC is important because it enables scientists to select samples within the context of the work that has already been done and facilitates better review of proposed allocations. It also provides back up material for public displays, captures information found only in abstracts, grey literature and curatorial databases and serves as a ready access to the now-vast scientific literature.

7 CFR 3405.9 - Use of funds for facilities.

Code of Federal Regulations, 2014 CFR

2014-01-01

... AGRICULTURE HIGHER EDUCATION CHALLENGE GRANTS PROGRAM Program Description § 3405.9 Use of funds for facilities. Under the Higher Education Challenge Grants Program, the use of grant funds to plan, acquire, or...

7 CFR 3405.9 - Use of funds for facilities.

Code of Federal Regulations, 2012 CFR

2012-01-01

... AGRICULTURE HIGHER EDUCATION CHALLENGE GRANTS PROGRAM Program Description § 3405.9 Use of funds for facilities. Under the Higher Education Challenge Grants Program, the use of grant funds to plan, acquire, or...

7 CFR 3405.9 - Use of funds for facilities.

Code of Federal Regulations, 2013 CFR

2013-01-01

... AGRICULTURE HIGHER EDUCATION CHALLENGE GRANTS PROGRAM Program Description § 3405.9 Use of funds for facilities. Under the Higher Education Challenge Grants Program, the use of grant funds to plan, acquire, or...

7 CFR 3405.9 - Use of funds for facilities.

Code of Federal Regulations, 2011 CFR

2011-01-01

... AGRICULTURE HIGHER EDUCATION CHALLENGE GRANTS PROGRAM Program Description § 3405.9 Use of funds for facilities. Under the Higher Education Challenge Grants Program, the use of grant funds to plan, acquire, or...

49 CFR 350.301 - What level of effort must a State maintain to qualify for MCSAP funding?

Code of Federal Regulations, 2012 CFR

2012-10-01

... funds and State matching funds, for CMV safety programs eligible for funding under this part at a level...) State funds used for federally sponsored demonstration or pilot CMV safety programs. (c) The State must...

49 CFR 350.301 - What level of effort must a State maintain to qualify for MCSAP funding?

Code of Federal Regulations, 2013 CFR

2013-10-01

... funds and State matching funds, for CMV safety programs eligible for funding under this part at a level...) State funds used for federally sponsored demonstration or pilot CMV safety programs. (c) The State must...

49 CFR 350.301 - What level of effort must a State maintain to qualify for MCSAP funding?

Code of Federal Regulations, 2014 CFR

2014-10-01

... funds and State matching funds, for CMV safety programs eligible for funding under this part at a level...) State funds used for federally sponsored demonstration or pilot CMV safety programs. (c) The State must...

Estimating Acceptability of Financial Health Incentives.

PubMed

Bigsby, Elisabeth; Seitz, Holli H; Halpern, Scott D; Volpp, Kevin; Cappella, Joseph N

2017-08-01

A growing body of evidence suggests that financial incentives can influence health behavior change, but research on the public acceptability of these programs and factors that predict public support have been limited. A representative sample of U.S. adults ( N = 526) were randomly assigned to receive an incentive program description in which the funding source of the program (public or private funding) and targeted health behavior (smoking cessation, weight loss, or colonoscopy) were manipulated. Outcome variables were attitude toward health incentives and allocation of hypothetical funding for incentive programs. Support was highest for privately funded programs. Support for incentives was also higher among ideologically liberal participants than among conservative participants. Demographics and health history differentially predicted attitude and hypothetical funding toward incentives. Incentive programs in the United States are more likely to be acceptable to the public if they are funded by private companies.

Public Health Preparedness Funding: Key Programs and Trends From 2001 to 2017.

PubMed

Watson, Crystal R; Watson, Matthew; Sell, Tara Kirk

2017-09-01

To evaluate trends in funding over the past 16 years for key federal public health preparedness and response programs at the US Department of Health and Human Services, to improve understanding of federal funding history in this area, and to provide context for future resource allocation decisions for public health preparedness. In this 2017 analysis, we examined the funding history of key federal programs critical to public health preparedness by reviewing program budget data collected for our annual examination of federal funding for biodefense and health security programs since fiscal year (FY) 2001. State and local preparedness at the Centers for Disease Control and Prevention initially received $940 million in FY2002 and resulted in significant preparedness gains, but funding levels have since decreased by 31%. Similarly, the Hospital Preparedness Program within the Office of the Assistant Secretary for Preparedness and Response was funded at a high of $515 million in FY2003, but funding was reduced by 50%. Investments in medical countermeasure development and stockpiling remained relatively stable. The United States has made significant progress in preparing for disasters and advancing public health infrastructure. To enable continued advancement, federal funding commitments must be sustained.

Public Health Preparedness Funding: Key Programs and Trends From 2001 to 2017

PubMed Central

Sell, Tara Kirk

2017-01-01

Objectives. To evaluate trends in funding over the past 16 years for key federal public health preparedness and response programs at the US Department of Health and Human Services, to improve understanding of federal funding history in this area, and to provide context for future resource allocation decisions for public health preparedness. Methods. In this 2017 analysis, we examined the funding history of key federal programs critical to public health preparedness by reviewing program budget data collected for our annual examination of federal funding for biodefense and health security programs since fiscal year (FY) 2001. Results. State and local preparedness at the Centers for Disease Control and Prevention initially received $940 million in FY2002 and resulted in significant preparedness gains, but funding levels have since decreased by 31%. Similarly, the Hospital Preparedness Program within the Office of the Assistant Secretary for Preparedness and Response was funded at a high of $515 million in FY2003, but funding was reduced by 50%. Investments in medical countermeasure development and stockpiling remained relatively stable. Conclusions. The United States has made significant progress in preparing for disasters and advancing public health infrastructure. To enable continued advancement, federal funding commitments must be sustained. PMID:28892451

45 CFR 2516.600 - How are funds for school-based service-learning programs distributed?

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 4 2010-10-01 2010-10-01 false How are funds for school-based service-learning... (Continued) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE SCHOOL-BASED SERVICE-LEARNING PROGRAMS Distribution of Funds § 2516.600 How are funds for school-based service-learning programs distributed? (a) Of...

45 CFR 2516.600 - How are funds for school-based service-learning programs distributed?

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 4 2011-10-01 2011-10-01 false How are funds for school-based service-learning... (Continued) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE SCHOOL-BASED SERVICE-LEARNING PROGRAMS Distribution of Funds § 2516.600 How are funds for school-based service-learning programs distributed? (a) Of...

77 FR 60922 - Criminal History Check Requirements for AmeriCorps State/National, Senior Companions, Foster...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-05

..., including RSVP, LSA, Non-profit Capacity Building, and the Social Innovation Fund (SIF) grant programs... programs including Campuses of Service, Serve America Fellows, Encore Fellows, Silver Scholars, the Social Innovation Fund, and activities funded under programs such as the Volunteer Generation Fund. The final rule...

45 CFR 2517.600 - How are funds for community-based service-learning programs distributed?

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 4 2010-10-01 2010-10-01 false How are funds for community-based service-learning... (Continued) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE COMMUNITY-BASED SERVICE-LEARNING PROGRAMS Distribution of Funds § 2517.600 How are funds for community-based service-learning programs distributed? All...

45 CFR 2517.600 - How are funds for community-based service-learning programs distributed?

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 4 2011-10-01 2011-10-01 false How are funds for community-based service-learning... (Continued) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE COMMUNITY-BASED SERVICE-LEARNING PROGRAMS Distribution of Funds § 2517.600 How are funds for community-based service-learning programs distributed? All...

48 CFR 2110.7002 - Contractor investment of FEGLI Program funds.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Contractor investment of FEGLI Program funds. (a) The Contractor is required to invest and reinvest all FEGLI... Contractor is required to credit income earned from its investment of FEGLI Program funds to the FEGLI... appropriate manner. If the Contractor fails to invest funds on hand, properly allocate investment income, or...

78 FR 37277 - CDFI Bond Guarantee Program; Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-20

... the CDFI Fund in the following format: no more than 40 single-sided pages; double spaced; 12 font size... mail to the attention of Lisa Jones, Program Manager, CDFI Bond Guarantee Program, CDFI Fund, U.S... to the attention of Lisa Jones, Program Manager, CDFI Bond Guarantee Program, CDFI Fund, 1801-6215...

Federal Funding for Health Security in FY2015

PubMed Central

Sell, Tara Kirk; Watson, Matthew

2014-01-01

Previous articles in this series have provided funding information for federal civilian biodefense programs and programs focused on radiological and nuclear preparedness and consequence management. This year the authors have expanded the focus of the analysis to US federal funding for health security. This article provides proposed funding amounts for FY2015, estimated amounts for FY2014, and actual amounts for FY2010 through FY2013 in 5 domains critical to health security: biodefense programs, radiological and nuclear programs, chemical programs, pandemic influenza and emerging infectious disease programs, and multiple-hazard and preparedness programs. PMID:24988432

5 CFR 410.304 - Funding training programs.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false Funding training programs. 410.304 Section 410.304 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS TRAINING Establishing and Implementing Training Programs § 410.304 Funding training programs. Section 4112 of title 5...

RELAP5 Analyses of OECD/NEA ROSA-2 Project Experiments on Intermediate-Break LOCAs at Hot Leg or Cold Leg

NASA Astrophysics Data System (ADS)

Takeda, Takeshi; Maruyama, Yu; Watanabe, Tadashi; Nakamura, Hideo

Experiments simulating PWR intermediate-break loss-of-coolant accidents (IBLOCAs) with 17% break at hot leg or cold leg were conducted in OECD/NEA ROSA-2 Project using the Large Scale Test Facility (LSTF). In the hot leg IBLOCA test, core uncovery started simultaneously with liquid level drop in crossover leg downflow-side before loop seal clearing (LSC) induced by steam condensation on accumulator coolant injected into cold leg. Water remained on upper core plate in upper plenum due to counter-current flow limiting (CCFL) because of significant upward steam flow from the core. In the cold leg IBLOCA test, core dryout took place due to rapid liquid level drop in the core before LSC. Liquid was accumulated in upper plenum, steam generator (SG) U-tube upflow-side and SG inlet plenum before the LSC due to CCFL by high velocity vapor flow, causing enhanced decrease in the core liquid level. The RELAP5/MOD3.2.1.2 post-test analyses of the two LSTF experiments were performed employing critical flow model in the code with a discharge coefficient of 1.0. In the hot leg IBLOCA case, cladding surface temperature of simulated fuel rods was underpredicted due to overprediction of core liquid level after the core uncovery. In the cold leg IBLOCA case, the cladding surface temperature was underpredicted too due to later core uncovery than in the experiment. These may suggest that the code has remaining problems in proper prediction of primary coolant distribution.

Bioanalysis works in the IAA AMS facility: Comparison of AMS analytical method with LSC method in human mass balance study

NASA Astrophysics Data System (ADS)

Miyaoka, Teiji; Isono, Yoshimi; Setani, Kaoru; Sakai, Kumiko; Yamada, Ichimaro; Sato, Yoshiaki; Gunji, Shinobu; Matsui, Takao

2007-06-01

Institute of Accelerator Analysis Ltd. (IAA) is the first Contract Research Organization in Japan providing Accelerator Mass Spectrometry (AMS) analysis services for carbon dating and bioanalysis works. The 3 MV AMS machines are maintained by validated analysis methods using multiple control compounds. It is confirmed that these AMS systems have reliabilities and sensitivities enough for each objective. The graphitization of samples for bioanalysis is prepared by our own purification lines including the measurement of total carbon content in the sample automatically. In this paper, we present the use of AMS analysis in human mass balance and metabolism profiling studies with IAA 3 MV AMS, comparing results obtained from the same samples with liquid scintillation counting (LSC). Human samples such as plasma, urine and feces were obtained from four healthy volunteers orally administered a 14C-labeled drug Y-700, a novel xanthine oxidase inhibitor, of which radioactivity was about 3 MBq (85 μCi). For AMS measurement, these samples were diluted 100-10,000-fold with pure-water or blank samples. The results indicated that AMS method had a good correlation with LSC method (e.g. plasma: r = 0.998, urine: r = 0.997, feces: r = 0.997), and that the drug recovery in the excreta exceeded 92%. The metabolite profiles of plasma, urine and feces obtained with HPLC-AMS corresponded to radio-HPLC results measured at much higher radioactivity level. These results revealed that AMS analysis at IAA is useful to measure 14C-concentration in bioanalysis studies at very low radioactivity level.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stuart Adler; L. Dunyushkina; S. Huff

The goal of this project was to develop an improved understanding of factors governing performance and degradation of mixed-conducting SOFC cathodes. Two new diagnostic tools were developed to help achieve this goal: (1) microelectrode half-cells for improved isolation of cathode impedance on thin electrolytes, and (2) nonlinear electrochemical impedance spectroscopy (NLEIS), a variant of traditional impedance that allows workers to probe nonlinear rates as a function of frequency. After reporting on the development and efficacy of these tools, this document reports on the use of these and other tools to better understand performance and degradation of cathodes based on themore » mixed conductor La{sub 1-x}Sr{sub x}CoO{sub 3-{delta}} (LSC) on gadolinia or samaria-doped ceria (GDC or SDC). We describe the use of NLEIS to measure O{sub 2} exchange on thin-film LSC electrodes, and show that O{sub 2} exchange is most likely governed by dissociative adsorption. We also describe parametric studies of porous LSC electrodes using impedance and NLEIS. Our results suggest that O{sub 2} exchange and ion transport co-limit performance under most relevant conditions, but it is O{sub 2} exchange that is most sensitive to processing, and subject to the greatest degradation and sample-to-sample variation. We recommend further work that focuses on electrodes of well-defined or characterized geometry, and probes the details of surface structure, composition, and impurities. Parallel work on primarily electronic conductors (LSM) would also be of benefit to developers, and to improved understanding of surface vs. bulk diffusion.« less

Collagen degradation products and proinflammatory cytokines in systemic and localized scleroderma.

PubMed

Becvár, R; Hulejová, H; Braun, M; Stork, J

2007-01-01

The aim of this study was to assess the degradation of collagen type I and proinflammatory cytokines in systemic and localized scleroderma compared with psoriasis and healthy controls. Total 99 individuals were examined - 24 with SSc, 22 with LSc, 39 patients with PsV and 14 healthy controls. U-PD and U-DPD were measured using a sensitive isocratic HPLC method. Serum levels of IL-6 and soluble IL-2R were assayed using commercial ELISA kits. In the SSc group U-PD and U-DPD levels (nmol/mmol creatinine) were increased compared with controls (P = 0.001) and with PsV (P = 0.006). IL-6 levels were increased compared with controls (P = 0.004) and with PsV (P = 0.002). IL-2R concentrations were insignificantly increased in comparison with controls and were lower than in PsV, but the difference was not significant. In the LSc group excretion of U-PD and U-DPD did not differ from controls, but was insignificantly decreased compared with PsV. IL-6 levels were increased compared with controls (P = 0.001) and also with PsV (P = 0.03). IL-2R concentrations were significantly increased in comparison with controls only (P = 0.03). In patients with SSc our data have shown the most intensive collagen degradation and simultaneously an active inflammation, as documented by IL-6, which reflects the pathological processes in the skin and visceral organs compared with PsV patients and healthy individuals. In the LSc group collagen degradation was similar to that in control groups, but a certain inflammatory activity was observed.

Bacterial versus fungal laccase: potential for micropollutant degradation

PubMed Central

2013-01-01

Relatively high concentrations of micropollutants in municipal wastewater treatment plant (WWTP) effluents underscore the necessity to develop additional treatment steps prior to discharge of treated wastewater. Microorganisms that produce unspecific oxidative enzymes such as laccases are a potential means to improve biodegradation of these compounds. Four strains of the bacterial genus Streptomyces (S. cyaneus, S. ipomoea, S. griseus and S. psammoticus) and the white-rot fungus Trametes versicolor were studied for their ability to produce active extracellular laccase in biologically treated wastewater with different carbon sources. Among the Streptomyces strains evaluated, only S. cyaneus produced extracellular laccase with sufficient activity to envisage its potential use in WWTPs. Laccase activity produced by T. versicolor was more than 20 times greater, the highest activity being observed with ash branches as the sole carbon source. The laccase preparation of S. cyaneus (abbreviated LSc) and commercial laccase from T. versicolor (LTv) were further compared in terms of their activity at different pH and temperatures, their stability, their substrate range, and their micropollutant oxidation efficiency. LSc and LTv showed highest activities under acidic conditions (around pH 3 to 5), but LTv was active over wider pH and temperature ranges than LSc, especially at near-neutral pH and between 10 and 25°C (typical conditions found in WWTPs). LTv was also less affected by pH inactivation. Both laccase preparations oxidized the three micropollutants tested, bisphenol A, diclofenac and mefenamic acid, with faster degradation kinetics observed for LTv. Overall, T. versicolor appeared to be the better candidate to remove micropollutants from wastewater in a dedicated post-treatment step. PMID:24152339

A Newton-Raphson Method Approach to Adjusting Multi-Source Solar Simulators

NASA Technical Reports Server (NTRS)

Snyder, David B.; Wolford, David S.

2012-01-01

NASA Glenn Research Center has been using an in house designed X25 based multi-source solar simulator since 2003. The simulator is set up for triple junction solar cells prior to measurements b y adjusting the three sources to produce the correct short circuit current, lsc, in each of three AM0 calibrated sub-cells. The past practice has been to adjust one source on one sub-cell at a time, iterating until all the sub-cells have the calibrated Isc. The new approach is to create a matrix of measured lsc for small source changes on each sub-cell. A matrix, A, is produced. This is normalized to unit changes in the sources so that Ax(delta)s = (delta)isc. This matrix can now be inverted and used with the known Isc differences from the AM0 calibrated values to indicate changes in the source settings, (delta)s = A ·'x.(delta)isc This approach is still an iterative one, but all sources are changed during each iteration step. It typically takes four to six steps to converge on the calibrated lsc values. Even though the source lamps may degrade over time, the initial matrix evaluation i s not performed each time, since measurement matrix needs to be only approximate. Because an iterative approach is used the method will still continue to be valid. This method may become more important as state-of-the-art solar cell junction responses overlap the sources of the simulator. Also, as the number of cell junctions and sources increase, this method should remain applicable.

The First Complete Chloroplast Genome Sequences in Actinidiaceae: Genome Structure and Comparative Analysis.

PubMed

Yao, Xiaohong; Tang, Ping; Li, Zuozhou; Li, Dawei; Liu, Yifei; Huang, Hongwen

2015-01-01

Actinidia chinensis is an important economic plant belonging to the basal lineage of the asterids. Availability of a complete Actinidia chloroplast genome sequence is crucial to understanding phylogenetic relationships among major lineages of angiosperms and facilitates kiwifruit genetic improvement. We report here the complete nucleotide sequences of the chloroplast genomes for Actinidia chinensis and A. chinensis var deliciosa obtained through de novo assembly of Illumina paired-end reads produced by total DNA sequencing. The total genome size ranges from 155,446 to 157,557 bp, with an inverted repeat (IR) of 24,013 to 24,391 bp, a large single copy region (LSC) of 87,984 to 88,337 bp and a small single copy region (SSC) of 20,332 to 20,336 bp. The genome encodes 113 different genes, including 79 unique protein-coding genes, 30 tRNA genes and 4 ribosomal RNA genes, with 16 duplicated in the inverted repeats, and a tRNA gene (trnfM-CAU) duplicated once in the LSC region. Comparisons of IR boundaries among four asterid species showed that IR/LSC borders were extended into the 5' portion of the psbA gene and IR contraction occurred in Actinidia. The clap gene has been lost from the chloroplast genome in Actinidia, and may have been transferred to the nucleus during chloroplast evolution. Twenty-seven polymorphic simple sequence repeat (SSR) loci were identified in the Actinidia chloroplast genome. Maximum parsimony analyses of a 72-gene, 16 taxa angiosperm dataset strongly support the placement of Actinidiaceae in Ericales within the basal asterids.

40 CFR 35.6225 - Activities eligible for funding under Core Program Cooperative Agreements.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Core Program Cooperative Agreements. 35.6225 Section 35.6225 Protection of Environment ENVIRONMENTAL... Superfund State Contracts for Superfund Response Actions Core Program Cooperative Agreements § 35.6225 Activities eligible for funding under Core Program Cooperative Agreements. (a) To be eligible for funding...

40 CFR 35.6225 - Activities eligible for funding under Core Program Cooperative Agreements.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Core Program Cooperative Agreements. 35.6225 Section 35.6225 Protection of Environment ENVIRONMENTAL... Superfund State Contracts for Superfund Response Actions Core Program Cooperative Agreements § 35.6225 Activities eligible for funding under Core Program Cooperative Agreements. (a) To be eligible for funding...

Workforce Training: Almost Half of States Fund Employment Placement and Training through Employer Taxes and Most Coordinate with Federally Funded Programs. Report to Congressional Requesters. GAO-04-282.

ERIC Educational Resources Information Center

Nilsen, Sigurd R.

2004-01-01

To help close gaps between employee skills and employer needs, both federal- and state-funded programs are providing training and helping employers find qualified employees. In 2002, states raised revenues from taxes levied on employers to fund their own programs. This study examined how many states used employer taxes to fund their own employment…

Life After the Ban: An Assessment of US Syringe Exchange Programs’ Attitudes About and Early Experiences With Federal Funding

PubMed Central

Martin, Erika G.; Bowman, Sarah E.; Mann, Marita R.; Beletsky, Leo

2012-01-01

Objectives. We aimed to determine whether syringe exchange programs (SEPs) currently receive or anticipate pursuing federal funding and barriers to funding applications following the recent removal of the long-standing ban on using federal funds for SEPs. Methods. We conducted a telephone-administered cross-sectional survey of US SEPs. Descriptive statistics summarized responses; bivariate analyses examined differences in pursuing funding and experiencing barriers by program characteristics. Results. Of the 187 SEPs (92.1%) that responded, 90.9% were legally authorized. Three received federal funds and 116 intended to pursue federal funding. Perceived federal funding barriers were common and included availability and accessibility of funds, legal requirements such as written police support, resource capacity to apply and comply with funding regulations, local political and structural organization, and concern around altering program culture. Programs without legal authorization, health department affiliation, large distribution, or comprehensive planning reported more federal funding barriers. Conclusions. Policy implementation gaps appear to render federal support primarily symbolic. In practice, funding opportunities may not be available to all SEPs. Increased technical assistance and legal reform could improve access to federal funds, especially for SEPs with smaller capacity and tenuous local support. PMID:22420810

75 FR 54388 - Sunshine Act Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-07

... LEGAL SERVICES CORPORATION Sunshine Act Meeting Time and Date: The Legal Services Corporation Board of Directors' Search Committee for LSC President (``Search Committee'' or ``Committee'') will meet... conclusion of the Committee's agenda. Location: Legal Services Corporation, 3333 K Street, NW., Washington...

78 FR 27339 - Private Attorney Involvement

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-10

... LEGAL SERVICES CORPORATION 45 CFR Part 1614 Private Attorney Involvement AGENCY: Legal Services... in the rulemaking workshops. SUMMARY: The Legal Services Corporation (LSC) is conducting two... to Mark Freedman, Senior Assistant General Counsel, Legal Services Corporation, 3333 K St NW...

Net aboveground biomass declines of four major forest types with forest ageing and climate change in western Canada's boreal forests.

PubMed

Chen, Han Y H; Luo, Yong

2015-10-01

Biomass change of the world's forests is critical to the global carbon cycle. Despite storing nearly half of global forest carbon, the boreal biome of diverse forest types and ages is a poorly understood component of the carbon cycle. Using data from 871 permanent plots in the western boreal forest of Canada, we examined net annual aboveground biomass change (ΔAGB) of four major forest types between 1958 and 2011. We found that ΔAGB was higher for deciduous broadleaf (DEC) (1.44 Mg ha(-1)  year(-1) , 95% Bayesian confidence interval (CI), 1.22-1.68) and early-successional coniferous forests (ESC) (1.42, CI, 1.30-1.56) than mixed forests (MIX) (0.80, CI, 0.50-1.11) and late-successional coniferous (LSC) forests (0.62, CI, 0.39-0.88). ΔAGB declined with forest age as well as calendar year. After accounting for the effects of forest age, ΔAGB declined by 0.035, 0.021, 0.032 and 0.069 Mg ha(-1)  year(-1) per calendar year in DEC, ESC, MIX and LSC forests, respectively. The ΔAGB declines resulted from increased tree mortality and reduced growth in all forest types except DEC, in which a large biomass loss from mortality was accompanied with a small increase in growth. With every degree of annual temperature increase, ΔAGB decreased by 1.00, 0.20, 0.55 and 1.07 Mg ha(-1)  year(-1) in DEC, ESC, MIX and LSC forests, respectively. With every cm decrease of annual climatic moisture availability, ΔAGB decreased 0.030, 0.045 and 0.17 Mg ha(-1)  year(-1) in ESC, MIX and LSC forests, but changed little in DEC forests. Our results suggest that persistent warming and decreasing water availability have profound negative effects on forest biomass in the boreal forests of western Canada. Furthermore, our results indicate that forest responses to climate change are strongly dependent on forest composition with late-successional coniferous forests being most vulnerable to climate changes in terms of aboveground biomass. © 2015 John Wiley & Sons Ltd.

The complete chloroplast DNA sequence of the green alga Oltmannsiellopsis viridis reveals a distinctive quadripartite architecture in the chloroplast genome of early diverging ulvophytes

PubMed Central

Pombert, Jean-François; Lemieux, Claude; Turmel, Monique

2006-01-01

Background The phylum Chlorophyta contains the majority of the green algae and is divided into four classes. The basal position of the Prasinophyceae has been well documented, but the divergence order of the Ulvophyceae, Trebouxiophyceae and Chlorophyceae is currently debated. The four complete chloroplast DNA (cpDNA) sequences presently available for representatives of these classes have revealed extensive variability in overall structure, gene content, intron composition and gene order. The chloroplast genome of Pseudendoclonium (Ulvophyceae), in particular, is characterized by an atypical quadripartite architecture that deviates from the ancestral type by a large inverted repeat (IR) featuring an inverted rRNA operon and a small single-copy (SSC) region containing 14 genes normally found in the large single-copy (LSC) region. To gain insights into the nature of the events that led to the reorganization of the chloroplast genome in the Ulvophyceae, we have determined the complete cpDNA sequence of Oltmannsiellopsis viridis, a representative of a distinct, early diverging lineage. Results The 151,933 bp IR-containing genome of Oltmannsiellopsis differs considerably from Pseudendoclonium and other chlorophyte cpDNAs in intron content and gene order, but shares close similarities with its ulvophyte homologue at the levels of quadripartite architecture, gene content and gene density. Oltmannsiellopsis cpDNA encodes 105 genes, contains five group I introns, and features many short dispersed repeats. As in Pseudendoclonium cpDNA, the rRNA genes in the IR are transcribed toward the single copy region featuring the genes typically found in the ancestral LSC region, and the opposite single copy region harbours genes characteristic of both the ancestral SSC and LSC regions. The 52 genes that were transferred from the ancestral LSC to SSC region include 12 of those observed in Pseudendoclonium cpDNA. Surprisingly, the overall gene organization of Oltmannsiellopsis cpDNA more closely resembles that of Chlorella (Trebouxiophyceae) cpDNA. Conclusion The chloroplast genome of the last common ancestor of Oltmannsiellopsis and Pseudendoclonium contained a minimum of 108 genes, carried only a few group I introns, and featured a distinctive quadripartite architecture. Numerous changes were experienced by the chloroplast genome in the lineages leading to Oltmannsiellopsis and Pseudendoclonium. Our comparative analyses of chlorophyte cpDNAs support the notion that the Ulvophyceae is sister to the Chlorophyceae. PMID:16472375

Furry pet allergens, fungal DNA and microbial volatile organic compounds (MVOCs) in the commercial aircraft cabin environment.

PubMed

Fu, Xi; Lindgren, Torsten; Guo, Moran; Cai, Gui-Hong; Lundgren, Håkan; Norbäck, Dan

2013-06-01

There has been concern about the cabin environment in commercial aircraft. We measured cat, dog and horse allergens and fungal DNA in cabin dust and microbial volatile organic compounds (MVOCs) in cabin air. Samples were collected from two European airline companies, one with cabins having textile seats (TSC) and the other with cabins having leather seats (LSC), 9 airplanes from each company. Dust was vacuumed from seats and floors in the flight deck and different parts of the cabin. Cat (Fel d1), dog (Can f1) and horse allergens (Equ cx) were analyzed by ELISA. Five sequences of fungal DNA were analyzed by quantitative PCR. MVOCs were sampled on charcoal tubes in 42 TSC flights, and 17 compounds were analyzed by gas chromatography mass spectrometry (GC-MS) with selective ion monitoring (SIM). MVOC levels were compared with levels in homes from Nordic countries. The weight of dust was 1.8 times larger in TSC cabins as compared to LSC cabins (p < 0.001). In cabins with textile seats, the geometric mean (GM) concentrations of Fel d1, Can f1 and Equ cx were 5359 ng g(-1), 6067 ng g(-1), and 13 703 ng g(-1) (GM) respectively. Levels of Fel d1, Can f1 and Equ cx were 50 times, 27 times and 75 times higher respectively, in TSC cabins as compared to LSC cabins (p < 0.001). GM levels of Aspergillus/Penicillium DNA, Aspergillus versicolor DNA, Stachybotrys chartarum DNA and Streptomyces DNA were all higher in TSC as compared to LSC (p < 0.05). The sum of MVOCs in cabin air (excluding butanols) was 3192 ng m(-3) (GM), 3.7 times higher than in homes (p < 0.001) and 2-methyl-1-butanol and 3-methyl-1-butanol concentrations were 15-17 times higher as compared to homes (p < 0.001). Concentrations of isobutanol, 1-butanol, dimethyldisulfide, 2-hexanone, 2-heptanone, 3-octanone, isobutyl acetate and ethyl-2-methylbutyrate were lower in cabin air as compared to homes (p < 0.05). In conclusion, textile seats are much more contaminated by pet allergens and fungal DNA than leather seats. The use of seats with smooth surfaces should be encouraged. The MVOC levels differed between cabin air and homes.

76 FR 16438 - Reallocation of American Recovery and Reinvestment Act Capital Funds-Capital Fund Grant Program...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-23

... Recovery and Reinvestment Act Capital Funds--Capital Fund Grant Program Under the American Recovery and...: Notice. SUMMARY: The American Recovery and Reinvestment Act of 2009 (the Recovery Act) included a $4...). The Recovery Act required that $3 billion of these funds be distributed as formula funds and the...

Clean Water State Revolving Fund

EPA Pesticide Factsheets

How the Clean Water State Revolving Fund works, how to obtain funding, program eligibility, innovative ways to use the funds to get the greatest water quality benefits and leverage financial resources of the program, and share success stories.

78 FR 25291 - Announcement of Funding Awards; Section 3 Program Coordination and Implementation; Fiscal Year 2010

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-30

... funding under the Notice of Funding Availability (NOFA) for the Section 3 Program Coordination and.... (The Catalog of Federal Domestic Assistance Number for currently funded Initiatives under the Section 3... Valentine Reid, 816-777-2390. 7 50,000.00 East Armour Boulevard, Jackson, MO 64112-1254. Section 3 Program...

25 CFR 170.143 - How can IRR Program funds be used for highway safety?

Code of Federal Regulations, 2014 CFR

2014-04-01

... 25 Indians 1 2014-04-01 2014-04-01 false How can IRR Program funds be used for highway safety? 170... RESERVATION ROADS PROGRAM Indian Reservation Roads Program Policy and Eligibility Highway Safety Functions § 170.143 How can IRR Program funds be used for highway safety? A tribe, tribal organization, tribal...

25 CFR 170.143 - How can IRR Program funds be used for highway safety?

Code of Federal Regulations, 2013 CFR

2013-04-01

... 25 Indians 1 2013-04-01 2013-04-01 false How can IRR Program funds be used for highway safety? 170... RESERVATION ROADS PROGRAM Indian Reservation Roads Program Policy and Eligibility Highway Safety Functions § 170.143 How can IRR Program funds be used for highway safety? A tribe, tribal organization, tribal...

25 CFR 170.143 - How can IRR Program funds be used for highway safety?

Code of Federal Regulations, 2012 CFR

2012-04-01

... 25 Indians 1 2012-04-01 2011-04-01 true How can IRR Program funds be used for highway safety? 170... RESERVATION ROADS PROGRAM Indian Reservation Roads Program Policy and Eligibility Highway Safety Functions § 170.143 How can IRR Program funds be used for highway safety? A tribe, tribal organization, tribal...

25 CFR 170.143 - How can IRR Program funds be used for highway safety?

Code of Federal Regulations, 2011 CFR

2011-04-01

... RESERVATION ROADS PROGRAM Indian Reservation Roads Program Policy and Eligibility Highway Safety Functions § 170.143 How can IRR Program funds be used for highway safety? A tribe, tribal organization, tribal... 25 Indians 1 2011-04-01 2011-04-01 false How can IRR Program funds be used for highway safety? 170...

25 CFR 170.143 - How can IRR Program funds be used for highway safety?

Code of Federal Regulations, 2010 CFR

2010-04-01

... RESERVATION ROADS PROGRAM Indian Reservation Roads Program Policy and Eligibility Highway Safety Functions § 170.143 How can IRR Program funds be used for highway safety? A tribe, tribal organization, tribal... 25 Indians 1 2010-04-01 2010-04-01 false How can IRR Program funds be used for highway safety? 170...

Evaluating public health resources: what happens when funding disappears?

PubMed

Freedman, Ariela M; Kuester, Sarah A; Jernigan, Jan

2013-11-14

Although various factors affect the sustainability of public health programs, funding levels can influence many aspects of program continuity. Program evaluation in public health typically does not assess the progress of initiatives after discontinuation of funding. The objective of this study was to describe the effect of funding loss following expiration of a 5-year federal grant awarded to state health departments for development of statewide obesity prevention partnerships. The study used qualitative methods involving semistructured key informant interviews with state health departments. Data were analyzed using thematic analysis for effect of funding loss on staffing, programs, partnerships, and implementation of state plans. Many of the programs that continued to run after the grant expired operated at reduced capacity, either reaching fewer people or conducting fewer program activities for the same population. Although many states were able to leverage funding from other sources, this shift in funding source often resulted in priorities changing to meet new funding requirements. Evaluation capacity suffered in all states. Nearly all states reported losing infrastructure and capacity to communicate widely with partners. All states reported a severe or complete loss of their ability to provide training and technical assistance to partners. Despite these reduced capacities, states reported several key resources that facilitated continued work on the state plan. Decisions regarding continuation of funding are often dependent on budget constraints, evidence of success, and perceived ability to succeed in the future. Evaluating public health funding decisions may help guide development of best practice strategies for supporting long-term program success.

76 FR 37174 - Capital Investment Program-New Starts and Small Starts Program Funds

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-24

... DEPARTMENT OF TRANSPORTATION Federal Transit Administration Capital Investment Program--New Starts... apportionment of the FY 2011 Capital Investment (New Starts and Small Starts) program funds. The funds will be... FY 2011, $1,596,800,000 was appropriated for the Capital Investments Grant Account, which includes...

76 FR 21325 - Notice of Funds Availability: Inviting Applications for the Market Access Program

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-15

... for the 2012 Market Access Program (MAP). The intended effect of this notice is to solicit... INFORMATION CONTACT: Entities wishing to apply for funding assistance should contact the Program Operations....gov/mos/programs/map.asp . SUPPLEMENTARY INFORMATION: I. Funding Opportunity Description Authority...

77 FR 59027 - Submission for OMB Review; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-25

... investment advisory programs. These programs, which include ``wrap fee'' and ``mutual fund wrap'' programs... most mutual funds. Under wrap fee and similar programs, a client's account is typically managed on a... also must retain certain indicia of ownership of all securities and funds in the account. The...

Continuous Improvement in State Funded Preschool Programs

ERIC Educational Resources Information Center

Jackson, Sarah L.

2012-01-01

State funded preschool programs were constantly faced with the need to change in order to address internal and external demands. As programs engaged in efforts towards change, minimal research was available on how to support continuous improvement efforts within the context unique to state funded preschool programs. Guidance available had…

Dewitt Wallace-Reader's Digest Fund National Library Power Program.

ERIC Educational Resources Information Center

School Library Media Annual (SLMA), 1993

1993-01-01

Describes the National Library Power Program, a collaborative effort sponsored by the Dewitt Wallace-Reader's Digest Fund in cooperation with local education funds and public school districts that was designed to create public elementary and middle school library programs that are central to the education program of the school. (LRW)

34 CFR 403.91 - How must funds be used under the Sex Equity Program?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 34 Education 3 2011-07-01 2011-07-01 false How must funds be used under the Sex Equity Program... EDUCATION PROGRAM What Kinds of Activities Does the Secretary Assist Under the Basic Programs? Sex Equity Program § 403.91 How must funds be used under the Sex Equity Program? Except as provided in § 403.92, each...

34 CFR 403.91 - How must funds be used under the Sex Equity Program?

Code of Federal Regulations, 2014 CFR

2014-07-01

... 34 Education 3 2014-07-01 2014-07-01 false How must funds be used under the Sex Equity Program... EDUCATION PROGRAM What Kinds of Activities Does the Secretary Assist Under the Basic Programs? Sex Equity Program § 403.91 How must funds be used under the Sex Equity Program? Except as provided in § 403.92, each...

34 CFR 403.91 - How must funds be used under the Sex Equity Program?

Code of Federal Regulations, 2012 CFR

2012-07-01

... 34 Education 3 2012-07-01 2012-07-01 false How must funds be used under the Sex Equity Program... EDUCATION PROGRAM What Kinds of Activities Does the Secretary Assist Under the Basic Programs? Sex Equity Program § 403.91 How must funds be used under the Sex Equity Program? Except as provided in § 403.92, each...

34 CFR 403.91 - How must funds be used under the Sex Equity Program?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 3 2010-07-01 2010-07-01 false How must funds be used under the Sex Equity Program... EDUCATION PROGRAM What Kinds of Activities Does the Secretary Assist Under the Basic Programs? Sex Equity Program § 403.91 How must funds be used under the Sex Equity Program? Except as provided in § 403.92, each...

34 CFR 403.91 - How must funds be used under the Sex Equity Program?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 34 Education 3 2013-07-01 2013-07-01 false How must funds be used under the Sex Equity Program... EDUCATION PROGRAM What Kinds of Activities Does the Secretary Assist Under the Basic Programs? Sex Equity Program § 403.91 How must funds be used under the Sex Equity Program? Except as provided in § 403.92, each...

7 CFR 1783.16 - How will the loans given from the revolving fund be serviced?

Code of Federal Regulations, 2010 CFR

2010-01-01

...) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE (CONTINUED) REVOLVING FUNDS FOR FINANCING WATER AND WASTEWATER PROJECTS (REVOLVING FUND PROGRAM) Revolving Fund Program Loans § 1783.16 How will the loans given...

Creative Partnerships for Funding Nursing Research

PubMed Central

McCann, Judith J.; Hills, Elizabeth Blanchard; Zauszniewski, Jaclene A.; Smith, Carol E.; Farran, Carol J.; Wilkie, Diana J.

2013-01-01

The Small Business Innovation Research (SBIR) program and the Small Business Technology Transfer Research (STTR) program are two federal funding mechanisms that some nurses in academic positions have used to support research and development of innovative nursing products or services. Both the SBIR and STTR mechanisms are excellent sources of funding for nurse researchers who want to capitalize on relationships with small businesses or obtain seed money to fund high risk projects with potential to attract new venture capital. This paper provides an overview of NIH-funded SBIR and STTR programs and summarizes similarities and differences between the programs. The paper also describes unique features of NIH SBIR and STTR funding mechanisms that differentiate them from other R-series funding mechanisms, reviews evaluation criteria for SBIR and STTR projects, and discusses critical partners and resources for proposal development. Finally, the paper describes characteristics of successful partnerships and provides examples of SBIR/STTR-funded projects. PMID:20719996

Creative partnerships for funding nursing research.

PubMed

McCann, Judith J; Hills, Elizabeth Blanchard; Zauszniewski, Jaclene A; Smith, Carol E; Farran, Carol J; Wilkie, Diana J

2011-02-01

The Small Business Innovation Research (SBIR) program and the Small Business Technology Transfer Research (STTR) program are two federal funding mechanisms that some nurses in academic positions have used to support research and development of innovative nursing products or services. Both the SBIR and STTR mechanisms are excellent sources of funding for nurse researchers who want to capitalize on relationships with small businesses or obtain seed money to fund high-risk projects with potential to attract new venture capital. This article provides an overview of National Institutes of Health (NIH)-funded SBIR and STTR programs and summarizes similarities and differences between the programs. The article also describes unique features of NIH SBIR and STTR funding mechanisms that differentiate them from other R-series funding mechanisms, reviews evaluation criteria for SBIR and STTR projects, and discusses critical partners and resources for proposal development. Finally, the article describes characteristics of successful partnerships and provides examples of SBIR/STTR-funded projects.

An Assessment of the Industry-Faculty Surgeon Relationship Within Colon and Rectum Surgical Training Programs.

PubMed

Patel, Sunil V; Klingel, Michelle; Sonoda, Toyooki

2016-01-01

Industry funding of surgical training programs poses a potential conflict of interest. With the recent implementation of the Sunshine Act, industry funding can be more accurately determined. To determine the financial relationship between faculty surgeons within colon and rectal fellowship programs and industry. Review of industry funding based on the first reporting period (August-December, 2013) using the Centers for Medicare and Medicaid Services online database. ACGME certified colon and rectum surgical fellowship programs. Overall, 343 Faculty surgeons from 55 colon and rectum surgical fellowship programs were identified using the American Board of Colon and Rectum Surgery website. There was complete identification of faculty surgeons in 47 (85.5%) programs, partially complete identification (i.e., >80%) in 6 (10.9%) programs, and inadequate identification of faculty in 2 (3.6%) programs. Industry funding as defined by the Sunshine Act included general payments (honorariums, consulting fees, food and beverage, and travel), research payments, and amount invested. In all, 69.1% of program directors and 59.4% of other faculty received at least one payment during the reporting period (Δ9.7%, 95% CI: -4.4% to 23.8%, p = 0.18). Program directors received higher amounts of funding than other faculty ($7072.90 vs. $2,819.29, Δ$4,253.61, 95% CI: $1132-$7375, p = 0.008). Overall, 49 of 53 (93%) programs had surgeons receive funding, with a median of 3.5 surgeons receiving funding per program. A total of 65 companies made payments to surgeons, with 80.1% of the funding categorized as general payments, 16.2% as investments, and 3.7% as research payments. Industry funding was common. This financial relationship poses a potential conflict of interest in training fellows for future practice. Copyright © 2016 Association of Program Directors in Surgery. Published by Elsevier Inc. All rights reserved.

Federal Funding for Health Security in FY2016.

PubMed

Boddie, Crystal; Sell, Tara Kirk; Watson, Matthew

2015-01-01

This article assesses US government funding in 5 domains critical to strengthening health security: biodefense programs, radiological and nuclear programs, chemical programs, pandemic influenza and emerging infectious disease programs, and multiple-hazard and preparedness programs. This year's article also highlights the emergency funding appropriated in FY2015 to enable the international and domestic response to the Ebola outbreak in West Africa.

Federal Funding for Health Security in FY2016

PubMed Central

Sell, Tara Kirk; Watson, Matthew

2015-01-01

This article assesses US government funding in 5 domains critical to strengthening health security: biodefense programs, radiological and nuclear programs, chemical programs, pandemic influenza and emerging infectious disease programs, and multiple-hazard and preparedness programs. This year's article also highlights the emergency funding appropriated in FY2015 to enable the international and domestic response to the Ebola outbreak in West Africa. PMID:26042863

25 CFR 170.135 - Can a tribe use Federal funds for its recreation, tourism, and trails program?

Code of Federal Regulations, 2010 CFR

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false Can a tribe use Federal funds for its recreation, tourism... Eligibility Recreation, Tourism and Trails § 170.135 Can a tribe use Federal funds for its recreation, tourism... funds for recreation, tourism, and trails programs if the programs are included in the IRRTIP...

25 CFR 170.135 - Can a tribe use Federal funds for its recreation, tourism, and trails program?

Code of Federal Regulations, 2013 CFR

2013-04-01

... 25 Indians 1 2013-04-01 2013-04-01 false Can a tribe use Federal funds for its recreation, tourism... Eligibility Recreation, Tourism and Trails § 170.135 Can a tribe use Federal funds for its recreation, tourism... funds for recreation, tourism, and trails programs if the programs are included in the IRRTIP...

25 CFR 170.135 - Can a tribe use Federal funds for its recreation, tourism, and trails program?

Code of Federal Regulations, 2011 CFR

2011-04-01

... 25 Indians 1 2011-04-01 2011-04-01 false Can a tribe use Federal funds for its recreation, tourism... Eligibility Recreation, Tourism and Trails § 170.135 Can a tribe use Federal funds for its recreation, tourism... funds for recreation, tourism, and trails programs if the programs are included in the IRRTIP...

25 CFR 170.135 - Can a tribe use Federal funds for its recreation, tourism, and trails program?

Code of Federal Regulations, 2012 CFR

2012-04-01

... 25 Indians 1 2012-04-01 2011-04-01 true Can a tribe use Federal funds for its recreation, tourism... Eligibility Recreation, Tourism and Trails § 170.135 Can a tribe use Federal funds for its recreation, tourism... funds for recreation, tourism, and trails programs if the programs are included in the IRRTIP...

25 CFR 170.135 - Can a tribe use Federal funds for its recreation, tourism, and trails program?

Code of Federal Regulations, 2014 CFR

2014-04-01

... 25 Indians 1 2014-04-01 2014-04-01 false Can a tribe use Federal funds for its recreation, tourism... Eligibility Recreation, Tourism and Trails § 170.135 Can a tribe use Federal funds for its recreation, tourism... funds for recreation, tourism, and trails programs if the programs are included in the IRRTIP...

Peer review, program officers and science funding.

PubMed

Roebber, Paul J; Schultz, David M

2011-04-12

Increased competition for research funding has led to growth in proposal submissions and lower funding-success rates. An agent-based model of the funding cycle, accounting for variations in program officer and reviewer behaviors, for a range of funding rates, is used to assess the efficiency of different proposal-submission strategies. Program officers who use more reviewers and require consensus can improve the chances of scientists submitting fewer proposals. Selfish or negligent reviewers reduce the effectiveness of submitting more proposals, but have less influence as available funding declines. Policies designed to decrease proposal submissions reduce reviewer workload, but can lower the quality of funded proposals. When available funding falls below 10-15% in this model, the most effective strategy for scientists to maintain funding is to submit many proposals.

77 FR 3788 - Announcement of Funding Awards for the Assisted Living Conversion Program; Fiscal Year 2010

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-25

... Awards for the Assisted Living Conversion Program; Fiscal Year 2010 AGENCY: Office of the Assistant... competition for funding under the Notice of Funding Availability (NOFA) for the Assisted Living Conversion... Assistance number for this program is 14.314. The Assisted Living Conversion Program is designed to provide...

77 FR 14364 - Comment Sought on Funding Pilot Program Participants Transitioning Out of the Rural Health Care...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-09

... Program Participants Transitioning Out of the Rural Health Care Pilot Program in Funding Year 2012 AGENCY..., the Wireline Competition Bureau seeks comment on whether to fund Rural Health Care Pilot Program... transition them into the permanent Rural Health Care support mechanism (RHC support mechanism). DATES...

32 CFR 536.154 - Claims involving tortfeasors other than nonappropriated fund employees: NAFI risk management...

Code of Federal Regulations, 2011 CFR

2011-07-01

... nonappropriated fund employees: NAFI risk management program (RIMP) claims. 536.154 Section 536.154 National... nonappropriated fund employees: NAFI risk management program (RIMP) claims. The risk management program (RIMP) is..., military and civilian employees, to use the family child care program and sports equipment, such claims are...

32 CFR 536.154 - Claims involving tortfeasors other than nonappropriated fund employees: NAFI risk management...

Code of Federal Regulations, 2014 CFR

2014-07-01

... nonappropriated fund employees: NAFI risk management program (RIMP) claims. 536.154 Section 536.154 National... nonappropriated fund employees: NAFI risk management program (RIMP) claims. The risk management program (RIMP) is..., military and civilian employees, to use the family child care program and sports equipment, such claims are...

32 CFR 536.154 - Claims involving tortfeasors other than nonappropriated fund employees: NAFI risk management...

Code of Federal Regulations, 2012 CFR

2012-07-01

... nonappropriated fund employees: NAFI risk management program (RIMP) claims. 536.154 Section 536.154 National... nonappropriated fund employees: NAFI risk management program (RIMP) claims. The risk management program (RIMP) is..., military and civilian employees, to use the family child care program and sports equipment, such claims are...

32 CFR 536.154 - Claims involving tortfeasors other than nonappropriated fund employees: NAFI risk management...

Code of Federal Regulations, 2013 CFR

2013-07-01

... nonappropriated fund employees: NAFI risk management program (RIMP) claims. 536.154 Section 536.154 National... nonappropriated fund employees: NAFI risk management program (RIMP) claims. The risk management program (RIMP) is..., military and civilian employees, to use the family child care program and sports equipment, such claims are...

Financing Early Childhood Education Programs: State, Federal, and Local Issues

ERIC Educational Resources Information Center

Hustedt, Jason T.; Barnett, W. Steven

2011-01-01

The landscape of financing early childhood education in the U.S. is complex. Programs run the gamut from tuition-supported private centers to public programs supported by federal, state, or local funds. Different funding streams are poorly coordinated. The federal government funds several major targeted programs that are available only to specific…

76 FR 68841 - New Markets Tax Credit Program

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-07

... DEPARTMENT OF THE TREASURY Community Development Financial Institutions Fund New Markets Tax Credit Program AGENCY: Community Development Financial Institutions Fund, U.S. Department of the Treasury... Financial Institutions Fund (CDFI Fund) and the Internal Revenue Service (IRS). All materials submitted will...

In Vivo RNA Interference Screening Identifies a Leukemia-Specific Dependence on Integrin Beta 3 Signaling

PubMed Central

Miller, Peter G.; Al-Shahrour, Fatima; Hartwell, Kimberly A.; Chu, Lisa P.; Järås, Marcus; Puram, Rishi V.; Puissant, Alexandre; Callahan, Kevin P.; Ashton, John; McConkey, Marie E.; Poveromo, Luke P.; Cowley, Glenn S.; Kharas, Michael G.; Labelle, Myriam; Shterental, Sebastian; Fujisaki, Joji; Silberstein, Lev; Alexe, Gabriela; Al-Hajj, Muhammad A.; Shelton, Christopher A.; Armstrong, Scott A.; Root, David E.; Scadden, David T.; Hynes, Richard O.; Mukherjee, Siddhartha; Stegmaier, Kimberly; Jordan, Craig T.; Ebert, Benjamin L.

2013-01-01

SUMMARY We used an in vivo short hairpin RNA (shRNA) screening approach to identify genes that are essential for MLL-AF9 acute myeloid leukemia (AML). We found that Integrin Beta 3 (Itgb3) is essential for murine leukemia cells in vivo, and for human leukemia cells in xenotransplantation studies. In leukemia cells, Itgb3 knockdown impaired homing, downregulated LSC transcriptional programs, and induced differentiation via the intracellular kinase, Syk. In contrast, loss of Itgb3 in normal HSPCs did not affect engraftment, reconstitution, or differentiation. Finally, we confirmed that Itgb3 is dispensable for normal hematopoiesis and required for leukemogenesis using an Itgb3 knockout mouse model. Our results establish the significance of the Itgb3 signaling pathway as a potential therapeutic target in AML. PMID:23770013

34 CFR 400.5 - Under what conditions may funds under the Act be used for the joint funding of programs?

Code of Federal Regulations, 2010 CFR

2010-07-01

... VOCATIONAL AND APPLIED TECHNOLOGY EDUCATION PROGRAMS-GENERAL PROVISIONS § 400.5 Under what conditions may... 34 Education 3 2010-07-01 2010-07-01 false Under what conditions may funds under the Act be used for the joint funding of programs? 400.5 Section 400.5 Education Regulations of the Offices of the...

Financing state newborn screening programs: sources and uses of funds.

PubMed

Johnson, Kay; Lloyd-Puryear, Michele A; Mann, Marie Y; Ramos, Lauren Raskin; Therrell, Bradford L

2006-05-01

Financing for newborn screening is different from virtually all other public health programs. All except 5 screening programs collect fees as the primary source of program funding. A fee-based approach to financing newborn screening has been adopted by most states, to ensure consistent funding for this critical public health activity. Two types of data are reported here, ie, primary data from a survey of 37 state public health agencies and findings from exploratory case studies from 7 states. Most of the programs that participated in this survey (73%) reported that their newborn screening funding increased between 2002 and 2005, typically through increased fees and to a lesser extent through Medicaid, Title V Maternal and Child Health Services Block Grant, and state general revenue funding. All of the responding states that collect fees (n = 31) use such funds to support laboratory expenses, and most (70%) finance short-term follow-up services and program management. Nearly one half (47%) finance longer-term follow-up services, case management, or family support beyond diagnosis. Other states (43%) finance genetic or nutritional counseling and formula foods or treatment. Regardless of the source of funds, the available evidence indicates that states are committed to maintaining their programs and securing the necessary financing for the initial screening through diagnosis. Use of federal funding is currently limited; however, pressure to provide dedicated federal funding would likely increase if national recommendations for a uniform newborn screening panel were issued.

Integrating Equity in a Public Health Funding Strategy.

PubMed

Joseph, Kristy T; Rice, Ketra; Li, Chunyu

2016-01-01

Equity can be valuable to guide decision makers about where to target funds; however, there are few studies for modeling vertical equity in public health program funding strategies. This case study modeled vertical equity in the funding strategy of the Centers for Disease Control and Prevention's Colorectal Cancer Control Program. To integrate vertical equity by using historical funding and health data, we (a) examined the need for colorectal cancer screening, (b) conducted multiple regressions to examine the relationship between factors of need and funding of states, (c) stratified states into similar need groups, (d) estimated vertical equity within groups, and (e) assessed equity in the funding distribution. Certain states with similar needs had high relative funding, whereas other states with similar needs had low relative funding. The methods used to integrate vertical equity in this case study could be applied in publicly funded programs to potentially minimize inequities and improve outcomes.

34 CFR 403.70 - How must funds be used under the State Programs and State Leadership Activities?

Code of Federal Regulations, 2010 CFR

2010-07-01

... State Leadership Activities? 403.70 Section 403.70 Education Regulations of the Offices of the... the Basic Programs? State Programs and State Leadership Activities § 403.70 How must funds be used under the State Programs and State Leadership Activities? A State shall use funds reserved under section...

An Analysis of Evaluation Plans in a Federally Funded Leadership Preparation Program: Implications for the Improvement of Practice

ERIC Educational Resources Information Center

Sanzo, Karen L.

2012-01-01

This study is a content analysis of selected federally funded leadership preparation program evaluation proposals for the 2008, 2009, and 2010 School Leadership Program grants. The United States Department of Education (USDE) began awarding funding in 2002 to develop and implement preparation programs for aspiring and current assistant principals…

78 FR 23893 - Notice of Funds Availability: Inviting Applications for the Market Access Program

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-23

... inviting proposals for the 2014 Market Access Program (MAP). The intended effect of this notice is to... Agricultural Service (FAS). The funding authority for MAP expires at the end of fiscal year 2013. This notice... program funding is reauthorized prior to that time. In the event this program is not reauthorized, or is...

34 CFR 403.70 - How must funds be used under the State Programs and State Leadership Activities?

Code of Federal Regulations, 2012 CFR

2012-07-01

... State Leadership Activities? 403.70 Section 403.70 Education Regulations of the Offices of the... the Basic Programs? State Programs and State Leadership Activities § 403.70 How must funds be used under the State Programs and State Leadership Activities? A State shall use funds reserved under section...

34 CFR 403.70 - How must funds be used under the State Programs and State Leadership Activities?

Code of Federal Regulations, 2011 CFR

2011-07-01

... State Leadership Activities? 403.70 Section 403.70 Education Regulations of the Offices of the... the Basic Programs? State Programs and State Leadership Activities § 403.70 How must funds be used under the State Programs and State Leadership Activities? A State shall use funds reserved under section...

34 CFR 403.70 - How must funds be used under the State Programs and State Leadership Activities?

Code of Federal Regulations, 2014 CFR

2014-07-01

... State Leadership Activities? 403.70 Section 403.70 Education Regulations of the Offices of the... the Basic Programs? State Programs and State Leadership Activities § 403.70 How must funds be used under the State Programs and State Leadership Activities? A State shall use funds reserved under section...

34 CFR 403.70 - How must funds be used under the State Programs and State Leadership Activities?

Code of Federal Regulations, 2013 CFR

2013-07-01

... State Leadership Activities? 403.70 Section 403.70 Education Regulations of the Offices of the... the Basic Programs? State Programs and State Leadership Activities § 403.70 How must funds be used under the State Programs and State Leadership Activities? A State shall use funds reserved under section...

Redesigning Introductory Science Courses to Teach Sustainability: Introducing the L(SC)2 Paradigm

NASA Astrophysics Data System (ADS)

Myers, J. D.; Campbell-Stone, E.; Massey, G.

2008-12-01

Modern societies consume vast quantities of Earth resources at unsustainable levels; at the same time, resource extraction, processing, production, use and disposal have resulted in environmental damage severe enough to threaten the life-support systems of our planet. These threats are produced by multiple, integrative and cumulative environmental stresses, i.e. syndromes, which result from human physical, ecological and social interactions with the environment in specific geographic places. In recent decades, recognition of this growing threat has lead to the concept of sustainability. The science needed to provide the knowledge and know-how for a successful sustainability transition differs markedly from the science that built our modern world. Sustainability science must balanced basic and applied research, promote integrative research focused on specific problems and devise a means of merging fundamental, general scientific principles with understanding of specific places. At the same time, it must use a variety of knowledge areas, i.e. biological systems, Earth systems, technological systems and social systems, to devise solutions to the many complex and difficult problems humankind faces. Clearly, sustainability science is far removed from the discipline-based science taught in most U.S. colleges. Many introductory science courses focus on content, lack context and do not integrate scientific disciplines. To prepare the citizens who will confront future sustainability issues as well as the scientists needed to devise future sustainability strategies, educators and scientists must redesign the typical college science course. A new course paradigm, Literacies and Scientific Content in Social Context (L(SC)2), is ideally suited to teach sustainability science. It offers an alternative approach to liberal science education by redefining and expanding the concept of the interdisciplinary course and merging it with the integrated science course. In addition to promoting scientific literacy, L(SC)2 courses explicitly promote mastery of fundamental quantitative and qualitative skills critical to science and commonly a barrier to student success in science. Scientific content addresses the principles and disciplines necessary to tackle the multifaceted problems that must be solved in any sustainability transition and illustrates the limitations on what can be accomplished. Finally, social context adds the place-based component that is critical to sustainability science while revealing how science impacts students' everyday lives. Experience in addressing realistic, real-life problems fosters the habits of mind necessary to address these problems and instills a sense of social and political efficacy and responsibility. The L(SC)2 course paradigm employs a variety of educational tools (active problem-based learning, collaborative work, peer instruction, interdisciplinarity, and global context-based instruction) that improve lasting comprehension by creating a more effective learning environment. In this paradigm, STEM students learn that although there may be a technically or scientifically optimal solution to a problem, it must be responsive to a society's social, legal, cultural and religious parameters. Conversely, students in non-STEM fields learn that solutions to societal problems must be scientifically valid and technologically feasible. The interaction of STEM and non-STEM students in L(SC)2 courses builds bridges between the natural and social sciences that are critical for a successful sustainability transition and lacking in most traditional science courses.

76 FR 17736 - Major Capital Investment Program-New Starts

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-30

... DEPARTMENT OF TRANSPORTATION Federal Transit Administration Major Capital Investment Program--New... unallocated Major Capital Investment (New Starts) program funds. The funds accelerate federal payments for new... projects. The funding will give a well-timed boost to communities that have made important investments in...

75 FR 79087 - Fund Availability Under the Supportive Services for Veteran Families Program

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-17

... DEPARTMENT OF VETERANS AFFAIRS Fund Availability Under the Supportive Services for Veteran... Veterans Affairs (VA) is announcing the availability of funds for supportive services grants under the Supportive Services for Veteran Families Program (SSVF Program). This Notice contains information concerning...

Who gets how much: funding formulas in federal public health programs.

PubMed

Buehler, James W; Holtgrave, David R

2007-01-01

Federal public health programs use a mix of formula-based and competitive methods to allocate funds among states and other constituent jurisdictions. Characteristics of formula-based allocations used by a convenience sample of four programs, three from the Centers for Disease Control and Prevention and one from the Health Resources and Services Administration, are described to illustrate formula-based allocation methods in public health. Data sources in these public health formulas include population counts and funding proportions based on historical precedent. None include factors that adjust allocations based on variations in the availability of local resources or the cost of delivering services. Formula-funded activities are supplemented by programs that target specific prevention needs or encourage development of innovative methods to address emerging problems, using set-aside funds. A public health finance research agenda should address ways to improve the fit between funding allocation formulas and program objectives.

Strong tobacco control program requirements and secure funding are not enough: lessons from Florida.

PubMed

Kennedy, Allison; Sullivan, Sarah; Hendlin, Yogi; Barnes, Richard; Glantz, Stanton

2012-05-01

Florida's Tobacco Pilot Program (TPP; 1998-2003), with its edgy Truth media campaign, achieved unprecedented youth smoking reductions and became a model for tobacco control programming. In 2006, 3 years after the TPP was defunded, public health groups restored funding for tobacco control programming by convincing Florida voters to amend their constitution. Despite the new program's strong legal structure, Governor Charlie Crist's Department of Health implemented a low-impact program. Although they secured the program's strong structure and funding, Florida's nongovernmental public health organizations did not mobilize to demand a high-impact program. Implementation of Florida's Amendment 4 demonstrates that a strong programmatic structure and secure funding are insufficient to ensure a successful public health program, without external pressure from nongovernmental groups.

34 CFR 682.421 - Funds transferred from the Federal Fund to the Operating Fund by a guaranty agency.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION FEDERAL FAMILY EDUCATION LOAN (FFEL) PROGRAM Administration of the Federal Family Education Loan Programs by a Guaranty... 34 Education 3 2010-07-01 2010-07-01 false Funds transferred from the Federal Fund to the...

78 FR 51750 - Sunshine Act Meeting; Cancellation-Institutional Advancement Committee

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-21

... LEGAL SERVICES CORPORATION Sunshine Act Meeting; Cancellation--Institutional Advancement Committee On August 8, 2013, the Legal Services Corporation (``LSC'' or ``Corporation'') issued a public announcement that the Institutional Advancement Committee will meet telephonically on August 20, 2013, at 4 p.m...

45 CFR 1621.1 - Purpose.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Regulations Relating to Public Welfare (Continued) LEGAL SERVICES CORPORATION CLIENT GRIEVANCE PROCEDURES... assistance to clients as required by the LSC Act and are accountable to clients and applicants for legal... about the denial of legal assistance and clients about the manner or quality of legal assistance...

Financial Recruitment Incentive Programs for Nursing Personnel in Canada.

PubMed

Mathews, Maria; Ryan, Dana

2015-03-01

Financial incentives are increasingly offered to recruit nursing personnel to work in underserved communities. The authors describe and compare the characteristics of federal, provincial and territorial financial recruitment incentive programs for registered nurses (RNs), nurse practitioners (NPs), licensed practical nurses (LPNs), registered practical nurses or registered psychiatric nurses. The authors identified incentive programs from government, health ministry and student aid websites and by contacting program officials. Only government-funded recruitment programs providing funding beyond the normal employee wages and benefits and requiring a service commitment were included. The authors excluded programs offered by hospitals, regional or private firms, and programs that rewarded retention. All provinces and territories except QC and NB offer financial recruitment incentive programs for RNs; six provinces (BC, AB, SK, ON, QC and NL) offer programs for NPs, and NL offers a program for LPNs. Programs include student loan forgiveness, tuition forgiveness, education bursaries, signing bonuses and relocation expenses. Programs target trainees, recent graduates and new hires. Funding and service requirements vary by program, and service requirements are not always commensurate with funding levels. This snapshot of government-funded recruitment incentives provides program managers with data to compare and improve nursing workforce recruitment initiatives. Copyright © 2015 Longwoods Publishing.

7 CFR 1740.5 - Matching funds.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 11 2011-01-01 2011-01-01 false Matching funds. 1740.5 Section 1740.5 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE... Grant Program § 1740.5 Matching funds. No matching funds are required in this program. ...

25 CFR 170.141 - What Federal funds are available for a tribe's highway safety activities?

Code of Federal Regulations, 2013 CFR

2013-04-01

... program funds under 23 U.S.C. 405; (d) Alcohol traffic safety program funds under 23 U.S.C. 408; (e... from the U.S. Department of Health and Human Services (HHS); (g) Indian Highway Safety Program 25 CFR...

25 CFR 170.141 - What Federal funds are available for a tribe's highway safety activities?

Code of Federal Regulations, 2014 CFR

2014-04-01

... program funds under 23 U.S.C. 405; (d) Alcohol traffic safety program funds under 23 U.S.C. 408; (e... from the U.S. Department of Health and Human Services (HHS); (g) Indian Highway Safety Program 25 CFR...

25 CFR 170.141 - What Federal funds are available for a tribe's highway safety activities?

Code of Federal Regulations, 2012 CFR

2012-04-01

... program funds under 23 U.S.C. 405; (d) Alcohol traffic safety program funds under 23 U.S.C. 408; (e... from the U.S. Department of Health and Human Services (HHS); (g) Indian Highway Safety Program 25 CFR...

7 CFR 220.6 - Use of funds.

Code of Federal Regulations, 2011 CFR

2011-01-01

... CHILD NUTRITION PROGRAMS SCHOOL BREAKFAST PROGRAM § 220.6 Use of funds. (a) Federal funds made available under the School Breakfast Program shall be used by State agencies, or FNSROs where applicable, to reimburse or make advance payments to School Food Authorities in connection with breakfasts served in...

7 CFR 220.6 - Use of funds.

Code of Federal Regulations, 2010 CFR

2010-01-01

... CHILD NUTRITION PROGRAMS SCHOOL BREAKFAST PROGRAM § 220.6 Use of funds. (a) Federal funds made available under the School Breakfast Program shall be used by State agencies, or FNSROs where applicable, to reimburse or make advance payments to School Food Authorities in connection with breakfasts served in...

31 CFR 205.24 - How are accurate estimates maintained?

Code of Federal Regulations, 2010 CFR

2010-07-01

... EFFICIENT FEDERAL-STATE FUNDS TRANSFERS Rules Applicable to Federal Assistance Programs Included in a... funding technique provisions in the Treasury-State agreement or take other mutually agreed upon corrective... funds to be transferred under the Federal assistance program or program component to which an estimate...

Analysis of the Complete Chloroplast Genome of a Medicinal Plant, Dianthus superbus var. longicalyncinus, from a Comparative Genomics Perspective.

PubMed

Raman, Gurusamy; Park, SeonJoo

2015-01-01

Dianthus superbus var. longicalycinus is an economically important traditional Chinese medicinal plant that is also used for ornamental purposes. In this study, D. superbus was compared to its closely related family of Caryophyllaceae chloroplast (cp) genomes such as Lychnis chalcedonica and Spinacia oleracea. D. superbus had the longest large single copy (LSC) region (82,805 bp), with some variations in the inverted repeat region A (IRA)/LSC regions. The IRs underwent both expansion and constriction during evolution of the Caryophyllaceae family; however, intense variations were not identified. The pseudogene ribosomal protein subunit S19 (rps19) was identified at the IRA/LSC junction, but was not present in the cp genome of other Caryophyllaceae family members. The translation initiation factor IF-1 (infA) and ribosomal protein subunit L23 (rpl23) genes were absent from the Dianthus cp genome. When the cp genome of Dianthus was compared with 31 other angiosperm lineages, the infA gene was found to have been lost in most members of rosids, solanales of asterids and Lychnis of Caryophyllales, whereas rpl23 gene loss or pseudogization had occurred exclusively in Caryophyllales. Nevertheless, the cp genome of Dianthus and Spinacia has two introns in the proteolytic subunit of ATP-dependent protease (clpP) gene, but Lychnis has lost introns from the clpP gene. Furthermore, phylogenetic analysis of individual protein-coding genes infA and rpl23 revealed that gene loss or pseudogenization occurred independently in the cp genome of Dianthus. Molecular phylogenetic analysis also demonstrated a sister relationship between Dianthus and Lychnis based on 78 protein-coding sequences. The results presented herein will contribute to studies of the evolution, molecular biology and genetic engineering of the medicinal and ornamental plant, D. superbus var. longicalycinus.

Analysis of the Complete Chloroplast Genome of a Medicinal Plant, Dianthus superbus var. longicalyncinus, from a Comparative Genomics Perspective

PubMed Central

Raman, Gurusamy; Park, SeonJoo

2015-01-01

Dianthus superbus var. longicalycinus is an economically important traditional Chinese medicinal plant that is also used for ornamental purposes. In this study, D. superbus was compared to its closely related family of Caryophyllaceae chloroplast (cp) genomes such as Lychnis chalcedonica and Spinacia oleracea. D. superbus had the longest large single copy (LSC) region (82,805 bp), with some variations in the inverted repeat region A (IRA)/LSC regions. The IRs underwent both expansion and constriction during evolution of the Caryophyllaceae family; however, intense variations were not identified. The pseudogene ribosomal protein subunit S19 (rps19) was identified at the IRA/LSC junction, but was not present in the cp genome of other Caryophyllaceae family members. The translation initiation factor IF-1 (infA) and ribosomal protein subunit L23 (rpl23) genes were absent from the Dianthus cp genome. When the cp genome of Dianthus was compared with 31 other angiosperm lineages, the infA gene was found to have been lost in most members of rosids, solanales of asterids and Lychnis of Caryophyllales, whereas rpl23 gene loss or pseudogization had occurred exclusively in Caryophyllales. Nevertheless, the cp genome of Dianthus and Spinacia has two introns in the proteolytic subunit of ATP-dependent protease (clpP) gene, but Lychnis has lost introns from the clpP gene. Furthermore, phylogenetic analysis of individual protein-coding genes infA and rpl23 revealed that gene loss or pseudogenization occurred independently in the cp genome of Dianthus. Molecular phylogenetic analysis also demonstrated a sister relationship between Dianthus and Lychnis based on 78 protein-coding sequences. The results presented herein will contribute to studies of the evolution, molecular biology and genetic engineering of the medicinal and ornamental plant, D. superbus var. longicalycinus. PMID:26513163

Precision of dual-energy X-ray absorptiometry of the knee and heel: methodology and implications for research to reduce bone mineral loss after spinal cord injury.

PubMed

Peppler, W T; Kim, W J; Ethans, K; Cowley, K C

2017-05-01

Methodological validation of dual-energy x-ray absorptiometry (DXA)-based measures of leg bone mineral density (BMD) based on the guidelines of the International Society for Clinical Densitometry. The primary objective of this study was to determine the precision of BMD estimates at the knee and heel using the manufacturer provided DXA acquisition algorithm. The secondary objective was to determine the smallest change in DXA-based measurement of BMD that should be surpassed (least significant change (LSC)) before suggesting that a biological change has occurred in the distal femur, proximal tibia and calcaneus. Academic Research Centre, Canada. Ten people with motor-complete SCI of at least 2 years duration and 10 people from the general population volunteered to have four DXA-based measurements taken of their femur, tibia and calcaneus. BMDs for seven regions of interest (RIs) were calculated, as were short-term precision (root-mean-square (RMS) standard deviation (g cm -2 ), RMS-coefficient of variation (RMS-CV, %)) and LSC. Overall, RMS-CV values were similar between SCI (3.63-10.20%, mean=5.3%) and able-bodied (1.85-5.73%, mean=4%) cohorts, despite lower absolute BMD values at each RIs in those with SCI (35%, heel to 54%, knee; P<0.0001). Precision was highest at the calcaneus and lowest at the femur. Except at the femur, RMS-CV values were under 6%. For DXA-based estimates of BMD at the distal femur, proximal tibia and calcaneus, these precision values suggest that LSC values >10% are needed to detect differences between treated and untreated groups in studies aimed at reducing bone mineral loss after SCI.

Assessment of DNA replication in central nervous system by Laser Scanning Cytometry

NASA Astrophysics Data System (ADS)

Lenz, Dominik; Mosch, Birgit; Bocsi, Jozsef; Arendt, Thomas; Tárnok, Attila

2004-07-01

μIn neurons of patients with Alzheimers's disease (AD) signs of cell cycle re-entry as well as polyploidy have been reported1, 2, indicating that the entire or a part of the genome of the neurons is duplicated before its death but mitosis is not initiated so that the cellular DNA content remains tetraploid. It was concluded, that this imbalance is the direct cause of the neuronal loss in AD3. Manual counting of polyploidal cells is possible but time consuming and possibly statistically insufficient. The aim of this study was to develop an automated method that detects the neuronal DNA content abnormalities with Laser Scanning Cytometry (LSC).Frozen sections of formalin-fixed brain tissue of AD patients and control subjects were labelled with anti-cyclin B and anti-NeuN antibodies. Immunolabelling was performed using Cy5- and Cy2-conjugated secondary antibodies and biotin streptavidin or tyramid signal amplification. In the end sections of 20m thickness were incubated with propidium iodide (PI) (50μg/ml) and covered on slides. For analysis by the LSC PI was used as trigger. Cells identified as neurons by NeuN expression were analyzed for cyclin B expression. Per specimen data of at least 10,000 neurons were acquired. In the frozen brain sections an automated quantification of the amount of nuclear DNA is possible with LSC. The DNA ploidy as well as the cell cycle distribution can be analyzed. A high number of neurons can be scanned and the duration of measuring is shorter than a manual examination. The amount of DNA is sufficiently represented by the PI fluorescence to be able to distinguish between eu- and polyploid neurons.

23 CFR 661.23 - How will a bridge project be programmed for funding once eligibility has been determined?

Code of Federal Regulations, 2011 CFR

2011-04-01

... 23 Highways 1 2011-04-01 2011-04-01 false How will a bridge project be programmed for funding once... TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS INDIAN RESERVATION ROAD BRIDGE PROGRAM § 661.23 How will a bridge project be programmed for funding once eligibility has been determined? (a) All projects will be...

25 CFR 170.808 - Can BIA Road Maintenance Program funds be used to improve IRR transportation facilities?

Code of Federal Regulations, 2010 CFR

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false Can BIA Road Maintenance Program funds be used to improve... THE INTERIOR LAND AND WATER INDIAN RESERVATION ROADS PROGRAM BIA Road Maintenance § 170.808 Can BIA Road Maintenance Program funds be used to improve IRR transportation facilities? No. BIA Road...

25 CFR 170.927 - How can FEMA Program funds be used to repair damage?

Code of Federal Regulations, 2011 CFR

2011-04-01

... 25 Indians 1 2011-04-01 2011-04-01 false How can FEMA Program funds be used to repair damage? 170.927 Section 170.927 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER INDIAN RESERVATION ROADS PROGRAM Miscellaneous Provisions Emergency Relief § 170.927 How can FEMA Program funds be...

25 CFR 170.927 - How can FEMA Program funds be used to repair damage?

Code of Federal Regulations, 2010 CFR

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false How can FEMA Program funds be used to repair damage? 170.927 Section 170.927 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER INDIAN RESERVATION ROADS PROGRAM Miscellaneous Provisions Emergency Relief § 170.927 How can FEMA Program funds be...

23 CFR 661.23 - How will a bridge project be programmed for funding once eligibility has been determined?

Code of Federal Regulations, 2010 CFR

2010-04-01

... 23 Highways 1 2010-04-01 2010-04-01 false How will a bridge project be programmed for funding once... TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS INDIAN RESERVATION ROAD BRIDGE PROGRAM § 661.23 How will a bridge project be programmed for funding once eligibility has been determined? (a) All projects will be...

77 FR 48592 - Bus and Bus Facilities Discretionary Program Funds

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-14

... to award the funds for capital investments aimed at replacing or rehabilitating transit... (DOT) Federal Transit Administration (FTA) announces the selection of capital projects for the State of... Facilities Program funds. As outlined in the NOFA, the Section 5309 funds would be awarded for capital...

24 CFR 761.15 - Qualifying for funding.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 24 Housing and Urban Development 4 2012-04-01 2012-04-01 false Qualifying for funding. 761.15... AND PUBLIC AND INDIAN HOUSING PROGRAMS) DRUG ELIMINATION PROGRAMS Grant Funding § 761.15 Qualifying for funding. (a) Qualifications for PHDEP funding—(1) Eligible applicants. The following are eligible...

40 CFR 35.108 - Funding period.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Funding period. 35.108 Section 35.108... ASSISTANCE Environmental Program Grants Preparing An Application § 35.108 Funding period. The Regional Administrator and applicant may negotiate the length of the funding period for environmental program grants...

40 CFR 35.108 - Funding period.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Funding period. 35.108 Section 35.108... ASSISTANCE Environmental Program Grants Preparing An Application § 35.108 Funding period. The Regional Administrator and applicant may negotiate the length of the funding period for environmental program grants...

40 CFR 35.108 - Funding period.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 1 2012-07-01 2012-07-01 false Funding period. 35.108 Section 35.108... ASSISTANCE Environmental Program Grants Preparing An Application § 35.108 Funding period. The Regional Administrator and applicant may negotiate the length of the funding period for environmental program grants...

40 CFR 35.108 - Funding period.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Funding period. 35.108 Section 35.108... ASSISTANCE Environmental Program Grants Preparing An Application § 35.108 Funding period. The Regional Administrator and applicant may negotiate the length of the funding period for environmental program grants...

40 CFR 35.108 - Funding period.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Funding period. 35.108 Section 35.108... ASSISTANCE Environmental Program Grants Preparing An Application § 35.108 Funding period. The Regional Administrator and applicant may negotiate the length of the funding period for environmental program grants...

24 CFR 761.15 - Qualifying for funding.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 24 Housing and Urban Development 4 2013-04-01 2013-04-01 false Qualifying for funding. 761.15... AND PUBLIC AND INDIAN HOUSING PROGRAMS) DRUG ELIMINATION PROGRAMS Grant Funding § 761.15 Qualifying for funding. (a) Qualifications for PHDEP funding—(1) Eligible applicants. The following are eligible...

7 CFR 1430.308 - Availability of funds.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 10 2010-01-01 2010-01-01 false Availability of funds. 1430.308 Section 1430.308 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT... Payment Program § 1430.308 Availability of funds. The total available program funds shall be $10 million...

7 CFR 1430.608 - Availability of funds.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 10 2010-01-01 2010-01-01 false Availability of funds. 1430.608 Section 1430.608 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT... Payment Program II (DDAP-II) § 1430.608 Availability of funds. The total available program funds shall be...

Postdoctoral Teaching of Geriatric Dentistry in U.S. Dental Schools.

PubMed

Ettinger, Ronald L; Goettsche, Zachary S; Qian, Fang

2017-10-01

The aim of this study was to determine the number and size of postdoctoral teaching programs in geriatric dentistry in U.S. dental schools and other health professions educational institutions and those programs with Health Resources and Services Administration (HRSA) funding. In 2015, all 67 U.S. dental schools were contacted via email with a questionnaire to ask if they had a postdoctoral program in geriatric dentistry; if they did, they were asked to report the length and size of the program. Directors of all 16 HRSA-funded geriatric fellowships were also invited to participate in the survey. Fifty-six of the 67 (83.6%) dental schools and 15 of the 16 (93.8%) HRSA-funded programs completed the questionnaire. Postdoctoral geriatric dentistry programs were reported in 12 dental schools and six medical institutions, although only six programs were currently accepting fellows. The length of the programs was 12-36 months. The maximum number of residents in any program was ten. The oldest program was in Minnesota; it began in 1981. The newest program was beginning in 2017 at Boston University as a revised version of its previous HRSA-funded program. The loss of HRSA funding has had a major negative impact on the number of training programs. Future research is needed to determine how the loss of HRSA-funded programs has affected the availability of educators in geriatric dentistry for dental schools and the services provided to the geriatric community.

Indian Education. Annual Report 1968-1969.

ERIC Educational Resources Information Center

Washington Office of the State Superintendent of Public Instruction, Olympia.

Compensatory education programs funded by Johnson-O'Malley categorical aid monies are described in this annual report on American Indian education in the State of Washington. Funds were allocated to school districts on the basis of need and merit of proposed programs. Programs funded provided food services, home visitors and counselors, teacher…

77 FR 24169 - Notice of Funds Availability: Inviting Applications for the Market Access Program

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-23

... for the 2013 Market Access Program (MAP). The intended effect of this notice is to solicit... not be considered. FOR FURTHER INFORMATION CONTACT: Entities wishing to apply for funding assistance... at http://www.fas.usda.gov/mos/programs/map.asp . SUPPLEMENTARY INFORMATION: I. Funding Opportunity...

Select Government Matching Fund Programs: An Examination of Characteristics and Effectiveness

ERIC Educational Resources Information Center

Council for Advancement and Support of Education (NJ1), 2004

2004-01-01

Government matching fund programs, at their most fundamental level, are state-based initiatives that match private donations to colleges and universities with public funds. These programs have proven to be effective methods of improving public colleges and universities and successful examples of public-private partnerships, which are key…

76 FR 54772 - Notice of Intent To Award Affordable Care Act Funding, Funding Opportunity Announcement CDC-RFA...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-02

... applications under the Nutrition, Physical Activity, and Obesity Program. These applications have been..., Physical Activity, and Obesity Program Funding Opportunity Announcement (FOA). Award Information... based on methodology published in the Nutrition, Physical Activity, and Obesity Program CDC-RFA-DP08-805...

34 CFR 674.18 - Use of funds.

Code of Federal Regulations, 2010 CFR

2010-07-01

..., DEPARTMENT OF EDUCATION FEDERAL PERKINS LOAN PROGRAM General Provisions § 674.18 Use of funds. (a) General. An institution shall deposit the funds it receives under the Federal Perkins Loan program into its... supplemental Federal Perkins Loan allocations for an award year to the Federal Work-Study program or Federal...

34 CFR 674.18 - Use of funds.

Code of Federal Regulations, 2011 CFR

2011-07-01

..., DEPARTMENT OF EDUCATION FEDERAL PERKINS LOAN PROGRAM General Provisions § 674.18 Use of funds. (a) General. An institution shall deposit the funds it receives under the Federal Perkins Loan program into its... supplemental Federal Perkins Loan allocations for an award year to the Federal Work-Study program or Federal...

75 FR 9453 - Submission for OMB Review; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-02

... certain investment advisory programs. These programs, which include ``wrap fee'' and ``mutual fund wrap... size of most mutual funds. Under wrap fee and similar programs, a client's account is typically managed... securities and funds in the account. The requirement that the sponsor (or its designee) obtain information...

7 CFR 225.5 - Payments to State agencies and use of Program funds.

Code of Federal Regulations, 2010 CFR

2010-01-01

... the State Program management and administration plan and any other information available to FNS. If a... Program management and administration plan. (3) Funding assurance. At the time FNS approves the State's management and administration plan, the State shall be assured of receiving State administrative funding...

7 CFR 225.5 - Payments to State agencies and use of Program funds.

Code of Federal Regulations, 2011 CFR

2011-01-01

... the State Program management and administration plan and any other information available to FNS. If a... Program management and administration plan. (3) Funding assurance. At the time FNS approves the State's management and administration plan, the State shall be assured of receiving State administrative funding...

42 CFR 456.719 - Funding for DUR program.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 4 2012-10-01 2012-10-01 false Funding for DUR program. 456.719 Section 456.719 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES... Claims Management System for Outpatient Drug Claims § 456.719 Funding for DUR program. FFP is available...

42 CFR 456.719 - Funding for DUR program.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 4 2014-10-01 2014-10-01 false Funding for DUR program. 456.719 Section 456.719 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES... Claims Management System for Outpatient Drug Claims § 456.719 Funding for DUR program. FFP is available...

7 CFR 3405.9 - Use of funds for facilities.

Code of Federal Regulations, 2010 CFR

2010-01-01

..., AND EXTENSION SERVICE, DEPARTMENT OF AGRICULTURE HIGHER EDUCATION CHALLENGE GRANTS PROGRAM Program Description § 3405.9 Use of funds for facilities. Under the Higher Education Challenge Grants Program, the use... 7 Agriculture 15 2010-01-01 2010-01-01 false Use of funds for facilities. 3405.9 Section 3405.9...

76 FR 34953 - Funding Opportunity Title: Risk Management Education in Targeted States (Targeted States Program...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-15

... Corporation Funding Opportunity Title: Risk Management Education in Targeted States (Targeted States Program... Corporation (FCIC), operating through the Risk Management Agency (RMA), announces its intent to award... same time as funding availability for similar but separate program, the Risk Management Education and...

A researcher's perceptions of United States Department of Agriculture funding in animal reproduction.

PubMed

Reeves, J J

2007-03-01

Dedicated funding for animal reproduction did not start until 1985 and was available primarily in the reproductive efficiency and physiology areas of the Animal Science Program. Funding for individual grants and duration of funding were similar between the National Institutes of Health and the USDA, typically in the range of 3 yr, with total direct costs of $150,000. The names of these programs have changed over time; the National Research Initiative Competitive Grants Program started in 1991 with a program in animal reproduction. The USDA did not change the award size for individual grants until 2001, when it gradually increased through 2003. The USDA then markedly increased individual grants in 2004 to a funding level of $300,000 to $500,000 over 3 to 4 yr. This has been beneficial for the funded scientist but discouraging to the applicants with high-ranking nonfunded grants. The number of grants funded per year is approaching a low critical number, with an average of only 10 new grants funded per year. At the present funding level it will be difficult for even the best scientist to sustain a research career based only on USDA funding.

Outcomes associated with 12 years of grant funding: the Pediatric Endocrinology Nursing Society grant program.

PubMed

Keil, Margaret F; Lipman, Terri H

2007-06-01

In 1990, the Pediatric Endocrinology Nursing Society (PENS) developed a grant program to provide funding to advance pediatric endocrinology nursing practice through basic and applied research. Minimal data exist regarding the effect of grant funding on professional development and research dissemination. The purpose of this study was to determine the extent that PENS' grant funding has resulted in professional presentations, publications, and further research funding. Nineteen grants that received funding were identified. Survey questions included whether the results of the PENS-funded study were presented, published, and resulted in subsequent funding from other sources. Outcome data were available for 11 of 18 grants (61%). All funded studies were presented at PENS conference; 55% were presented at other national or international conferences. Sixteen publications resulted from seven funded studies; 64% of PENS' funded studies led to additional funding, and 18% resulted in additional research studies. In summary, the research grant program of PENS funded 19 grants, which resulted in numerous publications, presentations, and, in some cases, additional research funding from other sources. Many grant recipients acknowledged that PENS was their first source of research funding and gave them the opportunity to become experienced in their role as clinical researchers.

78 FR 65933 - Restrictions on Legal Assistance With Respect to Criminal Proceedings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-04

... LEGAL SERVICES CORPORATION 45 CFR Part 1613 Restrictions on Legal Assistance With Respect to Criminal Proceedings AGENCY: Legal Services Corporation. ACTION: Notice of proposed rulemaking. SUMMARY: This proposed rule updates the Legal Services Corporation (LSC or Corporation) regulation on legal...

75 FR 76494 - Sunshine Act Meeting; Notice

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-08

... LEGAL SERVICES CORPORATION Sunshine Act Meeting; Notice TIME AND DATE: The Legal Services Corporation Board of Directors' Search Committee for LSC President (``Search Committee'' or ``Committee'') will meet on December 13, 2010. The meeting will begin at 10 a.m. (Eastern Time) and continue until...

75 FR 72842 - Sunshine Act Meeting; Notice

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-26

... LEGAL SERVICES CORPORATION Sunshine Act Meeting; Notice Time and Date: The Legal Services Corporation Board of Directors' Search Committee for LSC President (``Search Committee'' or ``Committee'') will meet on November 29, 2010. The meeting will begin at 12 p.m. (Eastern Time) and continue until...