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Sample records for lta pie results

  1. LTA Physics Design: Description of All MOX Pin LTA Design

    SciTech Connect

    Pavlovichev, A.M.

    2001-09-28

    In this document issued according to Work Release 02. P. 99-lb the results of neutronics studies of <<100%Pu>> MOX LTA design are presented. The parametric studies of infinite MOX-UOX grids, MOX-UOX core fragments and of VVER-1000 core with 3 MOX LTAs are performed. The neutronics parameters of MOX fueled core have been performed for the chosen design MOX LTA using the Russian 3D code BIPR-7A and 2D code PERMAK-A with the constants prepared by the cell spectrum code TVS-M.

  2. LTA structures and materials technology

    NASA Technical Reports Server (NTRS)

    Mayer, N. J.

    1975-01-01

    The state-of-the-art concerning structures and materials technology is reviewed. It is shown that many present materials developments resulting from balloon and aircraft research programs can be applied to new concepts in LTA vehicles. Both buoyant and semi-buoyant vehicles utilize similar approaches to solving structural problems and could involve pressurized non-rigid and unpressurized rigid structures. System designs common to both and vital to structural integrity include much of the past technology as well. Further research is needed in determination of structural loads, especially in future design concepts.

  3. Lea's Pies

    NASA Technical Reports Server (NTRS)

    1996-01-01

    The Technology Transfer Office at Stennis Space Center worked with a pie company owner to develop an inexpensive container that would protect pies and keep them in a near frozen condition for shipping in 48 hours. A NASA engineer made a thermal barrier envelope from a metalized mylar called 'space blanket material,' developed during the Apollo era. The envelope protects the pies from heat transfer. Pictured, a NASA engineer removes the temperature logger from a pecan pie shipped to him in a prototype envelope.

  4. Multi-PIE.

    PubMed

    Gross, Ralph; Matthews, Iain; Cohn, Jeff; Kanade, Takeo; Baker, Simon

    2010-05-01

    A close relationship exists between the advancement of face recognition algorithms and the availability of face databases varying factors that affect facial appearance in a controlled manner. The CMU PIE database has been very influential in advancing research in face recognition across pose and illumination. Despite its success the PIE database has several shortcomings: a limited number of subjects, single recording session and only few expressions captured. To address these issues we collected the CMU Multi-PIE database. It contains 337 subjects, imaged under 15 view points and 19 illumination conditions in up to four recording sessions. In this paper we introduce the database and describe the recording procedure. We furthermore present results from baseline experiments using PCA and LDA classifiers to highlight similarities and differences between PIE and Multi-PIE.

  5. First results of the 74-MHz Very Large Array-Pie Town link. Hercules A at low frequencies

    NASA Astrophysics Data System (ADS)

    Gizani, Nectaria A. B.; Cohen, A.; Kassim, N. E.

    2005-04-01

    We present the results of the first successful observations of the Pie Town link with the Very Large Array at 74 MHz on Hercules A. The improvement in resolution from 25 to 10 arcsec resolves the helical- and ring-like features seen at higher frequencies. We also present new high dynamic range images of this powerful radio galaxy at 325 MHz. Our low-frequency observations confirm the multiple outburst interpretation of the spectral index differences at high frequencies. A comparison between our radio and ROSAT X-ray data does not reveal any association between the X-ray emission from the cluster and the radio lobes. There are no extra regions of radio emission at 74 MHz.

  6. LTA structures and materials technology. [airships

    NASA Technical Reports Server (NTRS)

    Mayer, N. J.

    1975-01-01

    The state-of-the-art concerning structures and materials technology is reviewed. It is shown that many present materials developments resulting from balloon and aircraft research programs can be applied to new concepts in LTA vehicles. Both buoyant and semi-buoyant vehicles will utilize similar approaches to solving structural problems and could involve pressurized non-rigid and unpressurized rigid structures. System designs common to both and vital to structural integrity will include much of the past technology as well. Further research is needed in determination of structural loads, especially in future design concepts.

  7. Experimentally activated immune defence in female pied flycatchers results in reduced breeding success.

    PubMed

    Ilmonen, P; Taarna, T; Hasselquist, D

    2000-04-07

    Traditional explanations for the negative fitness consequences of parasitism have focused on the direct pathogenic effects of infectious agents. However, because of the high selection pressure by the parasites, immune defences are likely to be costly and trade off with other fitness-related traits, such as reproductive effort. In a field experiment, we immunized breeding female flycatchers with non-pathogenic antigens (diphtheria-tetanus vaccine), which excluded the direct negative effects of parasites, in order to test the consequences of activated immune defence on hosts' investment in reproduction and self-maintenance. Immunized females decreased their feeding effort and investment in self-maintenance (rectrix regrowth) and had lower reproductive output (fledgling quality and number) than control females injected with saline. Our results reveal the phenotypic cost of immune defence by showing that an activated immune system per se can lower the host's breeding success. This may be caused by an energetic or nutritional trade-off between immune function and physical workload when feeding young or be an adaptive response to 'infection' to avoid physiological disorders such as oxidative stress and immunopathology.

  8. LTA - Recent developments. [Lighter Than Air ships

    NASA Technical Reports Server (NTRS)

    Mayer, N. J.

    1977-01-01

    NASA-sponsored studies of existing and new LTA missions showed that airships looked very promising for some two dozen civil and military applications. These include surveillance of rural and urban areas, in the form of forest and police patrols; transport of very heavy large-volume maritime, industrial, and military payloads; coastal patrol and sea control; seismographic surveys; air pollution monitoring; and moving goods to remote areas; along with a number of less important but still attractive missions. A figure of merit of productivity (payload weight, ton moles per hour) was used to compare airships of various type and size. In each case, this criterion established an index of efficiency for evaluating not only conceptual approaches but also modes of flight. Some, in part unexpected, results of these studies are described.

  9. 1981 LTA technology assessment - Past and present

    NASA Technical Reports Server (NTRS)

    Ashford, R. L.; Levitt, B. B.; Mayer, N. J.; Vocar, J. M.; Woodward, D. E.

    1981-01-01

    A four-part presentation is made of (1) lessons learned from the design and operation of the 'classic' airships of the 1920s and 30s, with respect to such issues as construction, propulsion, control, instrumentation, ground handling, habitability, aerodynamics, and structure and construction; (2) lessons learned from the development of such specialized lighter-than-air (LTA) concepts as metal-clad airships, semi-buoyant lifting bodies, experimental, sport and commercial free balloons, high-altitude platforms, and tethered aerostats; (3) the current status of LTA technology in various countries, with emphasis on significant developments in configuration, dynamics, control, structures, materials, and propulsion; and (4) a projection of future trends. It is concluded that socio-economic factors will strongly influence and encourage LTA development in the 1990s.

  10. Aerial view of entire LTA base after completion of both ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Aerial view of entire LTA base after completion of both LTA ship hangars. Date unknown but probably circa 1945. - Marine Corps Air Station Tustin, Northern Lighter Than Air Ship Hangar, Meffett Avenue & Maxfield Street, Tustin, Orange County, CA

  11. Extended pie menus for immersive virtual environments.

    PubMed

    Gebhardt, Sascha; Pick, Sebastian; Leithold, Franziska; Hentschel, Bernd; Kuhlen, Torsten

    2013-04-01

    Pie menus are a well-known technique for interacting with 2D environments and so far a large body of research documents their usage and optimizations. Yet, comparatively little research has been done on the usability of pie menus in immersive virtual environments (IVEs). In this paper we reduce this gap by presenting an implementation and evaluation of an extended hierarchical pie menu system for IVEs that can be operated with a six-degrees-of-freedom input device. Following an iterative development process, we first developed and evaluated a basic hierarchical pie menu system. To better understand how pie menus should be operated in IVEs, we tested this system in a pilot user study with 24 participants and focus on item selection. Regarding the results of the study, the system was tweaked and elements like check boxes, sliders, and color map editors were added to provide extended functionality. An expert review with five experts was performed with the extended pie menus being integrated into an existing VR application to identify potential design issues. Overall results indicated high performance and efficient design.

  12. LTA measurements on shuttle cleaning nozzle

    NASA Technical Reports Server (NTRS)

    1995-01-01

    A laser transit anemometer was used to make flow field velocity measurements on a supersonic air/water cleaning nozzle used to clean liquid oxygen shuttle components at Kennedy Space Center. The velocity along the centerline of the nozzle was characterized by the LTA system and compared with CFD calculations to ascertain the optimum distance the nozzle should be placed from the liquid oxygen part for maximum cleaning..

  13. Listeria monocytogenes MDR transporters are involved in LTA synthesis and triggering of innate immunity during infection

    PubMed Central

    Tadmor, Keren; Pozniak, Yair; Burg Golani, Tamar; Lobel, Lior; Brenner, Moran; Sigal, Nadejda; Herskovits, Anat A.

    2014-01-01

    Multi-drug resistance (MDR) transporters are known eponymously for their ability to confer resistance to various antimicrobial drugs. However, it is likely that this is not their primary function and that MDR transporters evolved originally to play additional roles in bacterial physiology. In Listeria monocytogenes a set of MDR transporters was identified to mediate activation of innate immune responses during mammalian cell infection. This phenotype was shown to be dependent on c-di-AMP secretion, but the physiological processes underlying this phenomenon were not completely resolved. Here we describe a genetic approach taken to screen for L. monocytogenes genes or physiological pathways involved in MDR transporter-dependent triggering of the type I interferon response. We found that disruption of L. monocytogenes lipoteichoic acid (LTA) synthesis results in enhanced triggering of type I interferon responses in infected macrophage cells yet does not impact bacterial intracellular growth. This innate immune response required the MDR transporters and could be recapitulated by exposing macrophage cells to culture supernatants derived from LTA mutant bacteria. Notably, we found that the MDR transporters themselves are required for full production of LTA, an observation that links MDR transporters to LTA synthesis for the first time. In light of our findings, we propose that the MDR transporters play a role in regulating LTA synthesis, possibly via c-di-AMP efflux, a physiological function in cell wall maintenance that triggers the host innate immune system. PMID:24611134

  14. Aerial view of construction of both LTA ship hangars (looking ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Aerial view of construction of both LTA ship hangars (looking north) circa 1942. - Marine Corps Air Station Tustin, Northern Lighter Than Air Ship Hangar, Meffett Avenue & Maxfield Street, Tustin, Orange County, CA

  15. Aerial view of reroofing of northern LTA ship hangar, circa ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Aerial view of re-roofing of northern LTA ship hangar, circa 1957. - Marine Corps Air Station Tustin, Northern Lighter Than Air Ship Hangar, Meffett Avenue & Maxfield Street, Tustin, Orange County, CA

  16. Discovery of the cell-penetrating function of A2 domain derived from LTA subunit of Escherichia coli heat-labile enterotoxin.

    PubMed

    Liu, Di; Guo, Hua; Zheng, Wenyun; Zhang, Na; Wang, Tianwen; Wang, Ping; Ma, Xingyuan

    2016-06-01

    Heat-labile enterotoxin (LT) is a protein toxin produced by enterotoxigenic Escherichia coli (ETEC). As a bacterial toxin, LT holotoxin can enter intestinal epithelial cells and cause diarrhea. In addition, LT is also a powerful mucosal adjuvant capable of enhancing the strong immune responses to co-administered antigens. However, the LT immunological mechanism is still not clear in some aspects, especially with the respect to how the LTA subunit functions alone. Here, we discovered that the A2 domain of LTA could carry a fluorescent protein into cells, whose function is similar to a cell-penetrating peptide. The transmembrane-transporting ability of the A2 domain is non-specific in its cell-penetrating function, which was shown through testing with different cell types. Moreover, the LTA2 fusion protein penetrated a fluorescently labeled cell membrane that identified LTA2 internalization through membrane transport pathways, and showed it finally localized in the endoplasmic reticulum. Furthermore, low-temperature stress and pharmacological agent treatments showed that the LTA2 internalization route is a temperature-dependent process involving the clathrin-mediated endocytosis and the macropinocytosis pathways. These results could explain the internalization of the LTA subunit alone without the LTB pentamer, contributing to a better understanding of LTA working as a mucosal adjuvant; they also suggest that the A2 domain could be used as a novel transport vehicle for research and treatment of disease.

  17. Identifying P-phase arrivals with noise: An improved Kurtosis method based on DWT and STA/LTA

    NASA Astrophysics Data System (ADS)

    Li, Xibing; Shang, Xueyi; Wang, Zewei; Dong, Longjun; Weng, Lei

    2016-10-01

    A discrete wavelet transform (DWT) and short time average to long time average (STA/LTA)-based Kurtosis algorithm (W-S/L-K method) is proposed to pick the arrival time of the P-phase; this method advantageously combines the outstanding ability of retrieving the P-phase arrival information from wavelet coefficients at high resolutions with inherent reliability in obtaining the P-phase arrival time using the STA/LTA picking method. The W-S/L-K method uses local maximum amplitudes and local kurtosis onsets from the wavelet detail components to determine the P-phase arrival times reliably and accurately. It was tested and verified using microseismic data collected from the Yongshaba mine. The results show that the W-S/L-K method's rates of picking errors smaller than 5 ms, 10 ms, and 15 ms were 58%, 86%, and 97.5%, respectively, and the W-S/L-K method was able to pick higher quality P-phase arrival times than those determined using the Kurtosis, Skewness, STA/LTA, Kurtosis + STA/LTA, and Skewness + STA/LTA methods. The proposed method provides a reliable technique for accurately picking P-phase arrival times, especially for signals with low signal to noise ratios (SNRs), heavy tails, and spikes. Moreover, it is able to detect pure noise.

  18. Pie de Palo, Argentina: A cataclastic diapir

    NASA Astrophysics Data System (ADS)

    Vita-Finzi, Claudio

    2009-03-01

    The term cataclastic diapirism is proposed for the low-temperature extrusion of highly fractured rocks through more competent strata to produce domed topographies at the surface. The process is illustrated by reference to the geomorphology, neotectonics and microseismicity of the Pie de Palo, an elongated ridge in the western Sierras Pampeanas of Argentina composed of shattered and sheared Lower Palaeozoic rocks and subject to coseismic uplift. The Pie de Palo is conventionally interpreted as a fault-driven basement fold linked to low-angle eastward subduction of the Nazca plate beneath South America; the diapiric model implies instead that deformation is powered by regional compression from west-verging, near-surface, crustal shortening which results ultimately from Atlantic spreading.

  19. Stovetop Earth Pecan Pie

    NASA Astrophysics Data System (ADS)

    Robin, C. M.

    2005-12-01

    Many fluid mechanical experiments with direct applications to Earth Science are performed with sugary syrups using conceptually straightforward procedures. Corn syrup has indeed proven to be a godsend for those studying convection and related non-linear phenomena. In addition, however, it gives experimentalists a deep physical intuition for the interior workings of hot planets. The basic concepts behind plate tectonics and mantle convection are not difficult; indeed, although they may not be aware of it, most students probably have a basic intuitive understanding of fluid mechanics gained in their daily life. However, the large size and long time scale of geophysical processes may be quite intimidating to young students. Even a simple geophysical experiment requires a complicated array of coolers, heaters and measuring and recording equipment. It is of interest to introduce students to the geodynamical concepts that can be visualized in a high-tech lab using familiar processes and equipment. Using a homemade apparatus and grocery store supplies, I propose using a 'Stove-top Earth pecan pie' to introduce simple geodynamic concepts to middle- and high-school students. The initially cold syrup heats up and the pecans begin to float (continent formation), the syrup begins to convect (mantle convection), and convection slows down after the heat is removed (secular cooling). Even Wilson cycles can be simulated by moving the pan to one side or the other of the stovetop or heating element. The activity formally introduces students to convection and its application to the earth, and makes them think about plate motion, heat transfer, scaling, and experimental procedures. As an added bonus, they can eat their experiments after recess!

  20. Gene expression of 5-lipoxygenase and LTA4 hydrolase in renal tissue of nephrotic syndrome patients

    PubMed Central

    Menegatti, E; Roccatello, D; Fadden, K; Piccoli, G; De Rosa, G; Sena, L M; Rifai, A

    1999-01-01

    Leukotrienes (LT) of the 5-lipoxygenase pathway constitute a class of potent biological lipid mediators of inflammation implicated in the pathogenesis of different models of experimental glomerulonephritis. The key enzyme, 5-lipoxygenase (5-LO), catalyses oxygenation of arachidonic acid to generate the primary leukotriene LTA4. This LT, in turn, serves as a substrate for either LTA4 hydrolase, to form the potent chemoattractant LTB4, or LTC4 synthase, to produce the powerful vasoconstrictor LTC4. To investigate the potential role of LT in the pathogenesis of human glomerulonephritis with nephrotic syndrome, we examined the gene expression of 5-LO and LTA4 hydrolase in renal tissue of 21 adult patients with nephrotic syndrome and 11 controls. The patients consisted of 11 cases of membranous nephropathy (MN), seven focal and segmental glomerulosclerosis (FSGS), two non-IgA mesangial glomerulonephritis and one minimal change disease. Total RNA purified from renal tissue was reverse transcribed into cDNA and amplified with specific primers in a polymerase chain reaction (RT-PCR). Eight patients' renal tissue, four MN and four FSGS, co-expressed 5-LO and LTA4 hydrolase. In situ hybridization analysis revealed 5-LO expression and distribution limited to the interstitial cells surrounding the peritubular capillaries. Comparative clinical and immunohistological data showed that these eight patients had impaired renal function and interstitial changes that significantly correlated with 5-LO expression. These findings suggest that leukotrienes may play an important role in the pathogenesis of MN and FSGS. These results are also relevant to elucidating the pathophysiologic mechanisms which underlie progression to renal failure in these diseases. PMID:10337029

  1. Airships 101: Rediscovering the Potential of Lighter-Than-Air (LTA)

    NASA Technical Reports Server (NTRS)

    Melton, John E.; Hochstetler, Ronald D.

    2012-01-01

    An overview of airships past, present, and future is provided in a Powerpoint-formatted presentation. This presentation was requested for transfer to the British MOD by Paul Espinosa of NASA Ames, Code PX. The presentation provides general information about airships divided into four main categories: the legacy of NASA Ames in LTA (Lighter-Than-Air), LTA taxonomy and theory, LTA revival and missions, and LTA research and technology.

  2. The PIE Institute Project: Final Evaluation Report

    ERIC Educational Resources Information Center

    St. John, Mark; Carroll, Becky; Helms, Jen; Smith, Anita

    2008-01-01

    The Playful Invention and Exploration (PIE) Institute project was funded in 2005 by the National Science Foundation (NSF). For the past three years, Inverness Research has served as the external evaluator for the PIE project. The authors' evaluation efforts have included extensive observation and documentation of PIE project activities; ongoing…

  3. [Pie]: Re-Count and Recall

    ERIC Educational Resources Information Center

    Scott, Paul

    2008-01-01

    The number [pie] [approximately] 3.14159 is defined to be the ratio C/d of the circumference C to the diameter d of any given circle. In this article, the author looks at some surprising and unexpected places where [pie] occurs, and then thinks about some ways of remembering all those digits in the expansion of [pie].

  4. Phase selection controlled by sodium ions in the synthesis of FAU/LTA composite zeolite

    PubMed Central

    Hu, Linyan; Xie, Sujuan; Wang, Qingxia; Liu, Shenglin; Xu, Longya

    2009-01-01

    Zeolite faujasite (FAU), Linde type A (LTA) and FAU/LTA composite have been synthesized using tetramethylammonium cation (TMA+) as template, by adjusting only the concentration of Na+ ions in the initial solution (1.00 Al2O3 4.36 SiO2 : 2.39 (TMA)2 O : β Na2 O : 249.00H2 O). Na+ ions alter the phase composition of the product more than TMA+ or OH− ions. When Na2 O concentration [Na2 O] increases from 0.024 to 0.168, the product gradually changes from pure FAU to pure LTA via the formation of FAU/LTA composite with increasing LTA fraction. Interestingly, the induction periods of FAU and LTA in the FAU/LTA composite zeolite ([Na2 O] is 0.072) are both 13 h, quite different from the induction periods of their individual pure phases—45 h for FAU and 4 h for LTA. During the crystallization, the LTA/(FAU + LTA) fraction in the composite zeolite decreases in a nearly linear fashion. Scanning electron microscopy, thermogravimetry and differential thermal analysis indicate some difference between the properties of the FAU/LTA composite zeolite and of the mechanical mixture. PMID:27877264

  5. Phase selection controlled by sodium ions in the synthesis of FAU/LTA composite zeolite.

    PubMed

    Hu, Linyan; Xie, Sujuan; Wang, Qingxia; Liu, Shenglin; Xu, Longya

    2009-02-01

    Zeolite faujasite (FAU), Linde type A (LTA) and FAU/LTA composite have been synthesized using tetramethylammonium cation (TMA(+)) as template, by adjusting only the concentration of Na(+) ions in the initial solution (1.00 Al2O3 4.36 SiO2 : 2.39 (TMA)2 O : β Na2 O : 249.00H2 O). Na(+) ions alter the phase composition of the product more than TMA(+) or OH(-) ions. When Na2 O concentration [Na2 O] increases from 0.024 to 0.168, the product gradually changes from pure FAU to pure LTA via the formation of FAU/LTA composite with increasing LTA fraction. Interestingly, the induction periods of FAU and LTA in the FAU/LTA composite zeolite ([Na2 O] is 0.072) are both 13 h, quite different from the induction periods of their individual pure phases-45 h for FAU and 4 h for LTA. During the crystallization, the LTA/(FAU + LTA) fraction in the composite zeolite decreases in a nearly linear fashion. Scanning electron microscopy, thermogravimetry and differential thermal analysis indicate some difference between the properties of the FAU/LTA composite zeolite and of the mechanical mixture.

  6. Phase selection controlled by sodium ions in the synthesis of FAU/LTA composite zeolite

    NASA Astrophysics Data System (ADS)

    Hu, Linyan; Xie, Sujuan; Wang, Qingxia; Liu, Shenglin; Xu, Longya

    2009-01-01

    Zeolite faujasite (FAU), Linde type A (LTA) and FAU/LTA composite have been synthesized using tetramethylammonium cation (TMA +) as template, by adjusting only the concentration of Na + ions in the initial solution (1.00 Al2 O3 4.36 SiO2 : 2.39 (TMA)2 O : β Na2 O : 249.00H2 O). Na + ions alter the phase composition of the product more than TMA+ or OH- ions. When Na2 O concentration [Na2 O] increases from 0.024 to 0.168, the product gradually changes from pure FAU to pure LTA via the formation of FAU/LTA composite with increasing LTA fraction. Interestingly, the induction periods of FAU and LTA in the FAU/LTA composite zeolite ([Na2 O] is 0.072) are both 13 h, quite different from the induction periods of their individual pure phases—45 h for FAU and 4 h for LTA. During the crystallization, the LTA/(FAU + LTA) fraction in the composite zeolite decreases in a nearly linear fashion. Scanning electron microscopy, thermogravimetry and differential thermal analysis indicate some difference between the properties of the FAU/LTA composite zeolite and of the mechanical mixture.

  7. Genetic Variation on the BAT1-NFKBIL1-LTA Region of Major Histocompatibility Complex Class III Associates with Periodontitis

    PubMed Central

    Marchesani, Marja; Vlachopoulou, Efthymia; Mäntylä, Päivi; Paju, Susanna; Buhlin, Kåre; Suominen, Anna L.; Contreras, Johanna; Knuuttila, Matti; Hernandez, Marcela; Huumonen, Sisko; Nieminen, Markku S.; Perola, Markus; Sinisalo, Juha; Lokki, Marja-Liisa; Pussinen, Pirkko J.

    2014-01-01

    Periodontitis is a chronic inflammatory disease with a multifactorial etiology. We investigated whether human major histocompatibility complex (MHC) polymorphisms (6p21.3) are associated with periodontal parameters. Parogene 1 population samples (n = 169) were analyzed with 13,245 single nucleotide polymorphisms (SNPs) of the MHC region. Eighteen selected SNPs (P ≤ 0.001) were replicated in Parogene 2 population samples (n = 339) and the Health 2000 Survey (n = 1,420). All subjects had a detailed clinical and radiographic oral health examination. Serum lymphotoxin-α (LTA) concentrations were measured in the Parogene populations, and the protein was detected in inflamed periodontal tissue. In the Parogene 1 population, 10 SNPs were associated with periodontal parameters. The strongest associations emerged from the parameters bleeding on probing (BOP) and a probing pocket depth (PPD) of ≥6 mm with the genes BAT1, NFKBIL1, and LTA. Six SNPs, rs11796, rs3130059, rs2239527, rs2071591, rs909253, and rs1041981 (r2, ≥0.92), constituted a risk haplotype. In the Parogene 1 population, the haplotype had the strongest association with the parameter BOP, a PPD of ≥6 mm, and severe periodontitis with odds ratios (95% confidence intervals) of 2.63 (2.21 to 3.20), 2.90 (2.37 to 3.52), and 3.10 (1.63 to 5.98), respectively. These results were replicated in the other two populations. High serum LTA concentrations in the Parogene population were associated with the periodontitis risk alleles of the LTA SNPs (rs909253 and rs1041981) of the haplotype. In addition, the protein was expressed in inflamed gingival connective tissue. We identified a novel BAT1-NFKBIL1-LTA haplotype as a significant contributor to the risk of periodontitis. The genetic polymorphisms in the MHC class III region may be functionally important in periodontitis susceptibility. PMID:24566624

  8. Revised numerical wrapper for PIES code

    NASA Astrophysics Data System (ADS)

    Raburn, Daniel; Reiman, Allan; Monticello, Donald

    2015-11-01

    A revised external numerical wrapper has been developed for the Princeton Iterative Equilibrium Solver (PIES code), which is capable of calculating 3D MHD equilibria with islands. The numerical wrapper has been demonstrated to greatly improve the rate of convergence in numerous cases corresponding to equilibria in the TFTR device where magnetic islands are present. The numerical wrapper makes use of a Jacobian-free Newton-Krylov solver along with adaptive preconditioning and a sophisticated subspace-restricted Levenberg-Marquardt backtracking algorithm. The details of the numerical wrapper and several sample results are presented.

  9. Airship logistics: The LTA vehicle; a total cargo system

    NASA Technical Reports Server (NTRS)

    Hackney, L. R. M.

    1975-01-01

    Design considerations for logistics are dealt with as they pertain to the large rigid LTA vehicle as either a commercial or military cargo carrier. Pertinent factors discussed are: (1) the basic mission; (2) types of payload; (3) the payload space in regards to configuration and sizing, its capacity, and its loadability. A logistic capability comparison of selected cargo airships versus jumbo jets is also made.

  10. Code Analyses Supporting PIE of Weapons-Grade MOX Fuel

    SciTech Connect

    Ott, Larry J; Bevard, Bruce Balkcom; Spellman, Donald J; McCoy, Kevin

    2010-01-01

    The U.S. Department of energy has decided to dispose of a portion of the nation's surplus weapons-grade plutonium by reconstituting it into mixed oxide (MOX) fuel and irradiating the fuel in commercial power reactors. Four lead test assemblies (LTAs) were manufactured with weapons-grade mixed oxide (WG-MOX) fuel and irradiated in the Catawba Nuclear Station Unit 1, to a maximum fuel rod burnup of ~47.3 GWd/MTHM. As part of the fuel qualification process, five rods with varying burnups and initial plutonium contents were selected from one assembly and shipped to the Oak Ridge National Laboratory (ORNL) for hot cell examination. ORNL has provided analytical support for the post-irradiation examination (PIE) of these rods via extensive fuel performance modeling which has aided in instrument settings and PIE data interpretation. The results of these fuel performance simulations are compared in this paper with available PIE data.

  11. 21 CFR 152.126 - Frozen cherry pie.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Frozen cherry pie. 152.126 Section 152.126 Food... HUMAN CONSUMPTION FRUIT PIES Requirements for Specific Standardized Fruit Pies § 152.126 Frozen cherry pie. (a) Identity. (1) Frozen cherry pie (excluding baked and then frozen) is the food prepared...

  12. 21 CFR 152.126 - Frozen cherry pie.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 2 2013-04-01 2013-04-01 false Frozen cherry pie. 152.126 Section 152.126 Food... HUMAN CONSUMPTION FRUIT PIES Requirements for Specific Standardized Fruit Pies § 152.126 Frozen cherry pie. (a) Identity. (1) Frozen cherry pie (excluding baked and then frozen) is the food prepared...

  13. 21 CFR 152.126 - Frozen cherry pie.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 2 2011-04-01 2011-04-01 false Frozen cherry pie. 152.126 Section 152.126 Food... HUMAN CONSUMPTION FRUIT PIES Requirements for Specific Standardized Fruit Pies § 152.126 Frozen cherry pie. (a) Identity. (1) Frozen cherry pie (excluding baked and then frozen) is the food prepared...

  14. 21 CFR 152.126 - Frozen cherry pie.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 2 2014-04-01 2014-04-01 false Frozen cherry pie. 152.126 Section 152.126 Food... HUMAN CONSUMPTION FRUIT PIES Requirements for Specific Standardized Fruit Pies § 152.126 Frozen cherry pie. (a) Identity. (1) Frozen cherry pie (excluding baked and then frozen) is the food prepared...

  15. 21 CFR 152.126 - Frozen cherry pie.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 2 2012-04-01 2012-04-01 false Frozen cherry pie. 152.126 Section 152.126 Food... HUMAN CONSUMPTION FRUIT PIES Requirements for Specific Standardized Fruit Pies § 152.126 Frozen cherry pie. (a) Identity. (1) Frozen cherry pie (excluding baked and then frozen) is the food prepared...

  16. Polypropylene glycol is a selective binding inhibitor for LTA and other structurally related TLR2 agonists.

    PubMed

    Draing, Christian; Traub, Stephanie; Deininger, Susanne; Mang, Philippa; Möller, Heiko M; Manso, Miguel; Rossi, Francois; Morath, Siegfried; Hartung, Thomas; von Aulock, Sonja

    2008-03-01

    Polypropylene glycol (PPG) is commonly added to bacterial cultures to avoid foaming. However, lipoteichoic acid (LTA) from bacteria grown with PPG lacked cytokine-inducing potency in human blood. We tested the blocking efficacy of several glycols on the cytokine response to staphylococcal LTA in human blood. PPG 1200 was the most potent inhibitor tested, shown for TNF, IL-1beta, IL-6, IL-8, IL-10 and TGF-beta induction, and displayed no cytotoxic effects. TNF induction by Staphylococcus aureus or by Toll-like receptor (TLR)2 agonists (di- and triacylated lipopeptides and LTA) was also inhibited by PPG 1200, but not that induced by Escherichia coli or TLR4 agonists. In flow cytometric studies, PPG-carrying nanobeads bound more rhodamine-labeled LTA than those with glycerol. Additionally, the methyl group peak in the (1)H-NMR of LTA shifted after incubation with increasing PPG 1200 concentrations. Sequential incubation of polystyrene plates with LTA, then PPG 1200 and then blood, with washing steps in between, showed that LTA-induced TNF release was inhibited. But when PPG 1200 was pre-incubated with blood that was washed before LTA was added, TNF induction was not repressed, demonstrating that PPG binds LTA and not cellular structures. In summary, PPG 1200 is a novel inhibitor of cytokine induction by TLR2 agonists, which interferes directly with the ligands.

  17. 9 CFR 319.500 - Meat pies.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Meat pies. 319.500 Section 319.500... ORGANIZATION AND TERMINOLOGY; MANDATORY MEAT AND POULTRY PRODUCTS INSPECTION AND VOLUNTARY INSPECTION AND CERTIFICATION DEFINITIONS AND STANDARDS OF IDENTITY OR COMPOSITION Meat Food Entree Products, Pies,...

  18. 9 CFR 319.500 - Meat pies.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Meat pies. 319.500 Section 319.500... ORGANIZATION AND TERMINOLOGY; MANDATORY MEAT AND POULTRY PRODUCTS INSPECTION AND VOLUNTARY INSPECTION AND CERTIFICATION DEFINITIONS AND STANDARDS OF IDENTITY OR COMPOSITION Meat Food Entree Products, Pies,...

  19. Hybrid LTA vehicle controllability as affected by buoyancy ratio

    NASA Technical Reports Server (NTRS)

    Meyers, D. N.; Kubicki, P.; Tarczynski, T.; Fairbanks, A.; Piasecki, F. N.

    1979-01-01

    The zero and low speed controllability of heavy lift airships under various wind conditions as affected by the buoyancy ratio are investigated. A series of three hybrid LTA vehicls were examined, each having a dynamic thrust system comprised of four H-34 helicopters, but with buoyant envelopes of different volumes (and hence buoyancies), and with varying percentage of helium inflation and varying useful loads (hence gross weights). Buoyancy ratio, B, was thus examined varying from approximately 0.44 to 1.39. For values of B greater than 1.0, the dynamic thrusters must supply negative thrust (i.e. downward).

  20. Post irradiation effects (PIE) in integrated circuits

    NASA Technical Reports Server (NTRS)

    Shaw, D. C.; Lowry, L.; Barnes, C.; Zakharia, M.; Agarwal, S.; Rax, B.

    1991-01-01

    Post-irradiation effects (PIE) ranging from normal recovery to catastrophic failure have been observed in integrated circuits during the PIE period. Data presented show failure due to rebound after a 10 krad(Si) dose. In particular, five device types are investigated with varying PIE response. Special attention has been given to the HI1-507A analog multiplexer because its PIE response is extreme. X-ray diffraction has been uniquely employed to measure physical stress in the HI1-507A metallization. An attempt has been made to show a relationship between stress relaxation and radiation effects. All data presented support the current MIL-STD Method 1019.4 but demonstrate the importance of performing PIE measurements, even when mission doses are as low as 10 krad(Si).

  1. Fully Copper-Exchanged High-Silica LTA Zeolites as Unrivaled Hydrothermally Stable NH3 -SCR Catalysts.

    PubMed

    Ryu, Taekyung; Ahn, Nak Ho; Seo, Seungwan; Cho, Jung; Kim, Hyojun; Jo, Donghui; Park, Gi Tae; Kim, Pyung Soon; Kim, Chang Hwan; Bruce, Elliott L; Wright, Paul A; Nam, In-Sik; Hong, Suk Bong

    2017-03-13

    Diesel engine technology is still the most effective solution to meet tighter CO2 regulations in the mobility and transport sector. In implementation of fuel-efficient diesel engines, the poor thermal durability of lean nitrogen oxides (NOx ) aftertreatment systems remains as one major technical hurdle. Divalent copper ions when fully exchanged into high-silica LTA zeolites are demonstrated to exhibit excellent activity maintenance for NOx reduction with NH3 under vehicle simulated conditions even after hydrothermal aging at 900 °C, a critical temperature that the current commercial Cu-SSZ-13 catalyst cannot overcome owing to thermal deactivation. Detailed structural characterizations confirm the presence of Cu(2+) ions only at the center of single 6-rings that act not only as a catalytically active center, but also as a dealumination suppressor. The overall results render the copper-exchanged LTA zeolite attractive as a viable substitute for Cu-SSZ-13.

  2. The causal pie model: an epidemiological method applied to evolutionary biology and ecology.

    PubMed

    Wensink, Maarten; Westendorp, Rudi G J; Baudisch, Annette

    2014-05-01

    A general concept for thinking about causality facilitates swift comprehension of results, and the vocabulary that belongs to the concept is instrumental in cross-disciplinary communication. The causal pie model has fulfilled this role in epidemiology and could be of similar value in evolutionary biology and ecology. In the causal pie model, outcomes result from sufficient causes. Each sufficient cause is made up of a "causal pie" of "component causes". Several different causal pies may exist for the same outcome. If and only if all component causes of a sufficient cause are present, that is, a causal pie is complete, does the outcome occur. The effect of a component cause hence depends on the presence of the other component causes that constitute some causal pie. Because all component causes are equally and fully causative for the outcome, the sum of causes for some outcome exceeds 100%. The causal pie model provides a way of thinking that maps into a number of recurrent themes in evolutionary biology and ecology: It charts when component causes have an effect and are subject to natural selection, and how component causes affect selection on other component causes; which partitions of outcomes with respect to causes are feasible and useful; and how to view the composition of a(n apparently homogeneous) population. The diversity of specific results that is directly understood from the causal pie model is a test for both the validity and the applicability of the model. The causal pie model provides a common language in which results across disciplines can be communicated and serves as a template along which future causal analyses can be made.

  3. LTA application of a long trailing wire high speed/low weight reeling system

    NASA Technical Reports Server (NTRS)

    Werb, D. F.

    1975-01-01

    The successful development of a unique yet simple reeling system for handling long trailing tensile members at high speeds is described. This high speed when combined with the system simplicity, low weight and effective motive power consumption make this reeling system particularly attractive to LTA planners and designers for numerous LTA missions.

  4. The Cassini Solstice Mission: Streamlining Operations by Sequencing with PIEs

    NASA Technical Reports Server (NTRS)

    Vandermey, Nancy; Alonge, Eleanor K.; Magee, Kari; Heventhal, William

    2014-01-01

    The Cassini Solstice Mission (CSM) is the second extended mission phase of the highly successful Cassini/Huygens mission to Saturn. Conducted at a much-reduced funding level, operations for the CSM have been streamlined and simplified significantly. Integration of the science timeline, which involves allocating observation time in a balanced manner to each of the five different science disciplines (with representatives from the twelve different science instruments), has long been a labor-intensive endeavor. Lessons learned from the prime mission (2004-2008) and first extended mission (Equinox mission, 2008-2010) were utilized to design a new process involving PIEs (Pre-Integrated Events) to ensure the highest priority observations for each discipline could be accomplished despite reduced work force and overall simplification of processes. Discipline-level PIE lists were managed by the Science Planning team and graphically mapped to aid timeline deconfliction meetings prior to assigning discrete segments of time to the various disciplines. Periapse segments are generally discipline-focused, with the exception of a handful of PIEs. In addition to all PIEs being documented in a spreadsheet, allocated out-of-discipline PIEs were entered into the Cassini Information Management System (CIMS) well in advance of timeline integration. The disciplines were then free to work the rest of the timeline internally, without the need for frequent interaction, debate, and negotiation with representatives from other disciplines. As a result, the number of integration meetings has been cut back extensively, freeing up workforce. The sequence implementation process was streamlined as well, combining two previous processes (and teams) into one. The new Sequence Implementation Process (SIP) schedules 22 weeks to build each 10-week-long sequence, and only 3 sequence processes overlap. This differs significantly from prime mission during which 5-week-long sequences were built in 24 weeks

  5. 46 CFR 16.109 - Public Interest Exclusion (PIE).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Public Interest Exclusion (PIE). 16.109 Section 16.109... General § 16.109 Public Interest Exclusion (PIE). Service agents are subject to Public Interest Exclusion (PIE) actions in accordance with 49 CFR Part 40, subpart R. The PIE is an action which excludes...

  6. Optimization studies of a multikilowatt PIE CO2 laser

    NASA Astrophysics Data System (ADS)

    Nath, A. K.; Seguin, H. J. J.; Seguin, V. A.

    1986-02-01

    Detailes of an investigation of the operational performance of a 10 kW CW PIE CO2 laser are presented. The results obtained from the experiment, successfully scaled by an order of magnitude from an earlier proof-of-principle device, clearly document that the PIE excitation process can be effectively utilized in the design of very large volumen lasers. Optimization data further reveal that overall wallplug efficiency is commensurate with that obtained from E-beam sustained lasers; but at far less complexity and cost. As such, this relatively simple and reliable nonself-sustained excitation process appears attractive commercial for the development of very large and cost effective CW CO2 lasers.

  7. The development of novel LTA4H modulators to selectively target LTB4 generation

    PubMed Central

    Low, Caroline M.; Akthar, Samia; Patel, Dhiren F.; Löser, Stephan; Wong, Chi-Tung; Jackson, Patricia L.; Blalock, J. Edwin; Hare, Stephen A.; Lloyd, Clare M.; Snelgrove, Robert J.

    2017-01-01

    The pro-inflammatory mediator leukotriene B4 (LTB4) is implicated in the pathologies of an array of diseases and thus represents an attractive therapeutic target. The enzyme leukotriene A4 hydrolase (LTA4H) catalyses the distal step in LTB4 synthesis and hence inhibitors of this enzyme have been actively pursued. Despite potent LTA4H inhibitors entering clinical trials all have failed to show efficacy. We recently identified a secondary anti-inflammatory role for LTA4H in degrading the neutrophil chemoattractant Pro-Gly-Pro (PGP) and rationalized that the failure of conventional LTA4H inhibitors may be that they inadvertently prevented PGP degradation. We demonstrate that these inhibitors do indeed fail to discriminate between the dual activities of LTA4H, and enable PGP accumulation in mice. Accordingly, we have developed novel compounds that potently inhibit LTB4 generation whilst leaving PGP degradation unperturbed. These novel compounds could represent a safer and superior class of LTA4H inhibitors for translation into the clinic. PMID:28303931

  8. The development of novel LTA4H modulators to selectively target LTB4 generation

    NASA Astrophysics Data System (ADS)

    Low, Caroline M.; Akthar, Samia; Patel, Dhiren F.; Löser, Stephan; Wong, Chi-Tung; Jackson, Patricia L.; Blalock, J. Edwin; Hare, Stephen A.; Lloyd, Clare M.; Snelgrove, Robert J.

    2017-03-01

    The pro-inflammatory mediator leukotriene B4 (LTB4) is implicated in the pathologies of an array of diseases and thus represents an attractive therapeutic target. The enzyme leukotriene A4 hydrolase (LTA4H) catalyses the distal step in LTB4 synthesis and hence inhibitors of this enzyme have been actively pursued. Despite potent LTA4H inhibitors entering clinical trials all have failed to show efficacy. We recently identified a secondary anti-inflammatory role for LTA4H in degrading the neutrophil chemoattractant Pro-Gly-Pro (PGP) and rationalized that the failure of conventional LTA4H inhibitors may be that they inadvertently prevented PGP degradation. We demonstrate that these inhibitors do indeed fail to discriminate between the dual activities of LTA4H, and enable PGP accumulation in mice. Accordingly, we have developed novel compounds that potently inhibit LTB4 generation whilst leaving PGP degradation unperturbed. These novel compounds could represent a safer and superior class of LTA4H inhibitors for translation into the clinic.

  9. Bufexamac ameliorates LPS-induced acute lung injury in mice by targeting LTA4H

    PubMed Central

    Xiao, Qiang; Dong, Ningning; Yao, Xue; Wu, Dang; Lu, Yanli; Mao, Fei; Zhu, Jin; Li, Jian; Huang, Jin; Chen, Aifang; Huang, Lu; Wang, Xuehai; Yang, Guangxiao; He, Guangyuan; Xu, Yong; Lu, Weiqiang

    2016-01-01

    Neutrophils play an important role in the occurrence and development of acute lung injury (ALI). Leukotriene B4 (LTB4), a hydrolysis product of epoxide leukotriene A4 (LTA4) catalyzed by LTA4 hydrolase (LTA4H), is one of the most potent chemoattractants for neutrophil. Bufexamac is a drug widely used as an anti-inflammatory agent on the skin, however, the mechanism of action is still not fully understood. In this study, we found bufexamac was capable of specifically inhibiting LTA4H enzymatic activity and revealed the mode of interaction of bufexamac and LTA4H using X-ray crystallography. Moreover, bufexamac significantly prevented the production of LTB4 in neutrophil and inhibited the fMLP-induced neutrophil migration through inhibition of LTA4H. Finally, bufexamac significantly attenuated lung inflammation as reflected by reduced LTB4 levels and weakened neutrophil infiltration in bronchoalveolar lavage fluid from a lipopolysaccharide-induced ALI mouse model. In summary, our study indicates that bufexamac acts as an inhibitor of LTB4 biosynthesis and may have potential clinical applications for the treatment of ALI. PMID:27126280

  10. Variants in LTA, TNF, IL1B and IL10 genes associated with the clinical course of sepsis.

    PubMed

    Montoya-Ruiz, Carolina; Jaimes, Fabián A; Rugeles, Maria T; López, Juan Álvaro; Bedoya, Gabriel; Velilla, Paula A

    2016-12-01

    The aim of this study was to explore the association between some SNPs of the TNF, LTA, IL1B and IL10 genes with cytokine concentrations and clinical course in Colombian septic patients. We conducted a cross-sectional study to genotype 415 septic patients and 205 patients without sepsis for the SNPs -308(G/A) rs1800629 of TNF; +252 (G/A) rs909253 of LTA; -511(A/G) rs16944 and +3953(C/T) rs1143634 of IL1B; and -1082(A/G) rs1800896, -819(C/T) rs1800871 and -592(C/A) rs1800872 of IL10. The association of theses SNPs with the following parameters was evaluated: (1) the presence of sepsis; (2) severity and clinical outcomes; (3) APACHE II and SOFA scores; and (4) procalcitonin, C-reactive protein, tumor necrosis factor, lymphotoxin alpha, interleukin 1 beta and interleukin 10 plasma concentrations. We found an association between the SNP LTA +252 with the development of sepsis [OR 1.29 (1.00-1.68)]; the SNP IL10 -1082 with sepsis severity [OR 0.53 (0.29-0.97)]; the TNF -308 with mortality [OR 0.33 (0.12-0.95)]; and the IL10 -592 and IL10 -1082 with admission to the intensive care unit (ICU) [OR 3.36 (1.57-7.18)] and [OR 0.18 (0.04-0.86)], respectively. None of the SNPs were associated with cytokine levels, procalcitonin and C-reactive protein serum concentrations, nor with APACHE II and SOFA scores. Our results suggest that these genetic variants play an important role in the development of sepsis and its clinical course.

  11. 49 CFR 40.367 - Who initiates a PIE proceeding?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Who initiates a PIE proceeding? 40.367 Section 40... DRUG AND ALCOHOL TESTING PROGRAMS Public Interest Exclusions § 40.367 Who initiates a PIE proceeding? The following DOT officials may initiate a PIE proceeding: (a) The drug and alcohol program manager...

  12. The Mini-Casebook--Easy As Pie.

    ERIC Educational Resources Information Center

    Blythe, Hal; Sweet, Charlie

    2003-01-01

    Presents a casebook on the song "American Pie" that considers how to define the parameters of short narrative. Describes the creation of an end-of-term cumulative writing project that the authors have successfully employed for the last decade. Discusses how they put together a casebook that teaches the necessary research skills. (SG)

  13. Direct Logistic Fuel JP-8 Conversion in a Liquid Tin Anode Solid Oxide Fuel Cell (LTA-SOFC)

    DTIC Science & Technology

    2008-04-09

    Oxide Fuel Cell (LTA- SOFC ) Prepared By CellTech Power , LLC, 131 Flanders Road, MA, 01581 April, 2008 Final Report Contract... REPORT Direct Logistic Fuel JP-8 Conversion in a Liquid Tin Anode Solid Oxide Fuel Cell (LTA- SOFC ) 14. ABSTRACT 16. SECURITY CLASSIFICATION OF: This...logistic fuel only. The aim of this program was to advance LTA- SOFC technology with respect to direct conversion of JP-8. U 1. REPORT DATE (DD-MM-YYYY) 4

  14. A revolutionary and operational tethered aerostat system illustrating new LTA technology. [for ground-air-ground communications

    NASA Technical Reports Server (NTRS)

    Menke, J. A.

    1975-01-01

    An operational tethered aerostat system, which demonstrates utility of LTA systems, is described. It was made possible by development of a reliable tethered aerostat that is used to support broadcast equipment at an altitude of 10,000 feet. Two elements of the TCOM system, the aerostat and mooring station, are particularly relevant to the LTA Workshop. They demonstrate the feasibility of using LTA vehicles in real, operational, all-weather applications and, in addition, illustrate an advance in the overall technology base of LTA. The aerostat and the mooring station, including their technical design features and demonstrated performance characteristics, are described.

  15. PIE: an online prediction system for protein-protein interactions from text.

    PubMed

    Kim, Sun; Shin, Soo-Yong; Lee, In-Hee; Kim, Soo-Jin; Sriram, Ram; Zhang, Byoung-Tak

    2008-07-01

    Protein-protein interaction (PPI) extraction has been an important research topic in bio-text mining area, since the PPI information is critical for understanding biological processes. However, there are very few open systems available on the Web and most of the systems focus on keyword searching based on predefined PPIs. PIE (Protein Interaction information Extraction system) is a configurable Web service to extract PPIs from literature, including user-provided papers as well as PubMed articles. After providing abstracts or papers, the prediction results are displayed in an easily readable form with essential, yet compact features. The PIE interface supports more features such as PDF file extraction, PubMed search tool and network communication, which are useful for biologists and bio-system developers. The PIE system utilizes natural language processing techniques and machine learning methodologies to predict PPI sentences, which results in high precision performance for Web users. PIE is freely available at http://bi.snu.ac.kr/pie/.

  16. Asymmetric enrichment of PIE-1 in the Caenorhabditis elegans zygote mediated by binary counterdiffusion.

    PubMed

    Daniels, Brian R; Perkins, Edward M; Dobrowsky, Terrence M; Sun, Sean X; Wirtz, Denis

    2009-02-23

    To generate cellular diversity in developing organisms while simultaneously maintaining the developmental potential of the germline, germ cells must be able to preferentially endow germline daughter cells with a cytoplasmic portion containing specialized cell fate determinants not inherited by somatic cells. In Caenorhabditis elegans, germline inheritance of the protein PIE-1 is accomplished by first asymmetrically localizing the protein to the germplasm before cleavage and subsequently degrading residual levels of the protein in the somatic cytoplasm after cleavage. Despite its critical involvement in cell fate determination, the enrichment of germline determinants remains poorly understood. Here, combining live-cell fluorescence methods and kinetic modeling, we demonstrate that the enrichment process does not involve protein immobilization, intracellular compartmentalization, or localized protein degradation. Instead, our results support a heterogeneous reaction/diffusion model for PIE-1 enrichment in which the diffusion coefficient of PIE-1 is reversibly reduced in the posterior, resulting in a stable protein gradient across the zygote at steady state.

  17. PIE preparation of the MEGAPIE target

    NASA Astrophysics Data System (ADS)

    Wohlmuther, Michael; Wagner, Werner

    2012-12-01

    The MEGAPIE target, after successfully operating for 4 months at a beam power of 0.77 MW, is now being prepared for post irradiation examination PIE. The lead-bismuth eutectic (LBE) target was irradiated from August until December 2006, and in this period received a beam charge of 2.8 A h of 575 MeV protons. After that, the target was stored in the target storage facility of PSI, waiting for its post irradiation examination. In the meantime several campaigns of tests have been conducted by PSI and ZWILAG, the interim storage facility of Swiss nuclear power plants. In these tests the feasibility of the conditioning of the target and the extraction of sample material for the PIE has been proven. After transport to the hot cell facility at ZWILAG in June 2009, the dismantling of the MEGAPIE target started. It finally was cut into 21 pieces. Ten of these pieces will be shipped to the Hot Laboratory of PSI ('PSI hotlab') to extract samples from the structural materials as well as from the LBE. Currently it is foreseen that the sample extraction will start in the first half of 2011. The remaining parts of the MEGAPIE target were conditioned as radioactive waste. The present paper will mainly focus on the dismantling and first visual inspection of the MEGAPIE target. In addition an outlook on the PIE phase of MEGAPIE is given.

  18. Gain and saturation parameters of a multikilowatt PIE CO2 laser

    NASA Astrophysics Data System (ADS)

    Nikumb, S. K.; Seguin, H. J. J.; Seguin, V. A.; Reshef, H.

    1987-07-01

    Details of an experimental investigation of the small signal gain and saturation parameter of a 10 kW CW photoinitiated, impulse-enhanced, electrically excited (PIE) CO2 laser are presented. Measurements were made as a function of several device operational conditions, such as gas pressure, input electrical power, pulser ionization, and flow velocity. Gain profiles were also obtained, both from anode to cathode, and in the direction of gas flow. The results document the effectiveness of the PIE excitation technique, while providing detailed information on the gain medium. Such data are essential to the design of an efficient optical extraction system.

  19. SNPs in PTGS2 and LTA Predict Pain and Quality of Life in Long Term Lung Cancer Survivors

    PubMed Central

    Rausch, Sarah M.; Gonzalez, Brian D.; Clark, Matthew M.; Patten, Christi; Felten, Sara; Liu, Heshan; Li, Yafei; Sloan, Jeff; Yang, Ping

    2015-01-01

    PURPOSE Lung cancer survivors report the lowest quality of life relative to other cancer survivors. Pain is one of the most devastating, persistent, and incapacitating symptoms for lung cancer survivors. Prevalence rates vary with 80–100% of survivors experiencing cancer pain and healthcare costs are five times higher in cancer survivors with uncontrolled pain. Cancer pain often has a considerable impact on quality of life among cancer patients and cancer survivors. Therefore, early identification, and treatment is important. Although recent studies have suggested a relationship between single nucleotide polymorphisms (SNPs) in several cytokine and inflammation genes with cancer prognosis, associations with cancer pain are not clear. Therefore, the primary aim of this study was to identify SNPs related to pain in long term lung cancer survivors. PATIENTS AND METHODS Participants were enrolled in the Mayo Clinic Lung Cancer Cohort upon diagnosis of their lung cancer. 1149 Caucasian lung cancer survivors, (440 surviving < 3 years; 354 surviving 3–5 years; and 355 surviving> 5 years) completed study questionnaires and had genetic samples available. Ten SNPS from PTGS2 and LTA genes were selected based on the serum literature. Outcomes included pain, and quality of life as measured by the SF-8. RESULTS Of the 10 SNPs evaluated in LTA and PTGS2 genes, 3 were associated with pain severity (rs5277; rs1799964), social function (rs5277) and mental health (rs5275). These results suggested both specificity and consistency of these inflammatory gene SNPs in predicting pain severity in long term lung cancer survivors. CONCLUSION These results provide support for genetic predisposition to pain severity and may aid in identification of lung cancer survivors at high risk for morbidity and poor QOL. PMID:22464751

  20. Sex and the Cinema: What "American Pie" Teaches the Young

    ERIC Educational Resources Information Center

    Pearce, Sharyn

    2006-01-01

    This paper focuses on the wildly successful blockbuster "American Pie" teenpics, especially "American Pie 3--The Wedding". I argue that these films are specifically designed to appeal to teenage male audiences, and to provide lessons in sex and romance. Movies like this are especially important as they are experienced by far more teenagers than,…

  1. Characterisation of TNF block haplotypes affecting the production of TNF and LTA.

    PubMed

    Tan, J H; Temple, S E L; Kee, C; Waterer, G W; Tan, C R T; Gut, I; Price, P

    2011-02-01

    Polymorphisms in the central major histocompatibility complex (MHC) (particularly TNF and adjacent genes) associate with several immunopathological diseases and with susceptibility to pneumonia. The MHC is characterised by strong linkage disequilibrium (LD), so identification of loci affecting disease must be based on haplotypes. We have defined 31 tumour necrosis factor (TNF) block haplotypes (denoted FV1-31) in Caucasians, Asians and Australian Aboriginals. This study correlates the carriage of TNF block haplotypes with TNF and lymphotoxin alpha (LTA) protein production by peripheral blood mononuclear cells from 205 healthy Caucasian subjects, following in vitro stimulation with Streptococcus pneumoniae (S. pneumoniae; gram-positive bacteria), Escherichia coli (E. coli; gram-negative bacteria) or TNF over 4, 8 and 24 h. Fifteen haplotypes were present at >1%, accounting for 94.5% of the cohort. The haplotypes were grouped into five families based on common alleles. Following stimulation, cells from carriers of the FV10 haplotype (family 2) produced less LTA compared with non-FV10 carriers. Carriers of the FV18 haplotype (family 4) produced more LTA than other donors. Induction of TNF by S. pneumoniae following 24 h stimulation was also greater in donors with FV18. The FV18 haplotype associated with the 44.1 MHC ancestral haplotype (HLA-A2, -C5, -B44, -DRB1*0401 and -DQB1*0301) that has few disease associations. FV16 occurred in the 8.1 MHC haplotype (HLA-A2, B8, DR3) that is associated with multiple immunopathological diseases. FV16 did not affect TNF or LTA levels. The findings suggest that many genetic variations critical in vivo are not effectively modelled by short-term cultures.

  2. LUNAR MODULE TEST ARTICLE [LTA] [2R] IS MOVED FOR MATING TO LUNAR MODULE ADAPTER

    NASA Technical Reports Server (NTRS)

    1967-01-01

    The Lunar Module Test Article [LTA] 2R, for the second Saturn V mission, is being moved from the low bay of the Manned Spacecraft Operations Building for mating with the spacecraft Lunar Module Adapter. The second Saturn V [502], except for a different lunar return trajectory, will be a repeat of the Apollo 4 unmanned Earth orbital flight of a high apogee for systems testing using several propulsion system burns and a heat shield test at lunar re-entry speed.

  3. Crystal structures of Sr-diphylloaluminosilicates synthesized from LTA and FAU zeolites

    NASA Astrophysics Data System (ADS)

    Nedić, Bojana; Kremenović, Aleksandar; Dimitrijević, Radovan; Dondur, Vera

    2008-02-01

    Crystal structures of stoichiometric and non-stoichiometric Sr-diphylloaluminosilicate phases are solved and refined using X-ray powder diffraction (XRPD) data by Rietveld method in trigonal space group P3¯c1 (No. 165) and hexagonal space group P6 3/ mcm (No. 193), respectively. The stoichiometric phase is synthesized from the Sr-LTA zeolite, whereas the non-stoichiometric phase is prepared from the Sr-FAU zeolite by thermal treatment. Structural models described in the space group P3¯c1 are refined to the agreement factors: Rexp = 3.32, Rp = 6.63, Rwp = 9.27, RB = 3.70 for Sr-diphylloaluminosilicate LTA and Rexp = 3.64, Rp = 7.06, Rwp = 10.1, RB = 3.76 for Sr-diphylloaluminosilicate FAU. Structural models described in the space group P6 3/ mcm are refined to the agreement factors: Rexp = 3.32, Rp = 6.50, Rwp = 9.10, RB = 3.40 for Sr-diphylloaluminosilicate LTA and Rexp = 3.64, Rp = 6.92, Rwp = 9.90, RB = 3.55 for Sr-diphylloaluminosilicate FAU. Vacancies in the positions occupied by the Sr 2+ ions are characteristic of the Sr-diphylloaluminosilicate FAU structure.

  4. Comparison of the STA/LTA and power spectral density methods for microseismic event detection

    NASA Astrophysics Data System (ADS)

    Vaezi, Yoones; Van der Baan, Mirko

    2015-12-01

    Robust event detection and picking is a prerequisite for reliable (micro-) seismic interpretations. Detection of weak events is a common challenge among various available event detection algorithms. In this paper we compare the performance of two event detection methods, the short-term average/long-term average (STA/LTA) method, which is the most commonly used technique in industry, and a newly introduced method that is based on the power spectral density (PSD) measurements. We have applied both techniques to a 1-hr long segment of the vertical component of some raw continuous data recorded at a borehole geophone in a hydraulic fracturing experiment. The PSD technique outperforms the STA/LTA technique by detecting a higher number of weak events while keeping the number of false alarms at a reasonable level. The time-frequency representations obtained through the PSD method can also help define a more suitable bandpass filter which is usually required for the STA/LTA method. The method offers thus much promise for automated event detection in industrial, local, regional and global seismological data sets.

  5. Propulsion Induced Effects (PIE) Test Program

    NASA Technical Reports Server (NTRS)

    Cappuccio, Gelsomina; Won, Mark J.

    1999-01-01

    The Propulsion Induced Effects (PIE) test program is being lead by NASA Ames for Configuration Aerodynamics (CA). Representatives from CA, Technology Integration (TI), Inlet, and the Nozzle ITD's are working with Ames in defining and executing this test program. The objective of the CA 4-14 milestone is to assess the propulsion/airframe integration characteristics of the Technology Concept Airplane (TCA) and design variations using computational and experimental methods. The experimental aspect includes static calibrations, transonic and supersonic wind tunnel testing. The test program will generate a comprehensive database that will include all appropriate wind tunnel corrections, with emphasis placed on establishing the propulsion induced effects on the flight performance of the TCA.

  6. 49 CFR 40.379 - How do you contest the issuance of a PIE?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false How do you contest the issuance of a PIE? 40.379... issuance of a PIE? (a) If you receive a NOPE, you may contest the issuance of the PIE. (b) If you want to contest the proposed PIE, you must provide the Director information and argument in opposition to...

  7. 49 CFR 40.377 - Who decides whether to issue a PIE?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Who decides whether to issue a PIE? 40.377 Section... a PIE? (a) The ODAPC Director, or his or her designee, decides whether to issue a PIE. If a designee... determination about whether to start a PIE proceeding. (c) There is a “firewall” between the initiating...

  8. 49 CFR 40.363 - On what basis may the Department issue a PIE?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false On what basis may the Department issue a PIE? 40... the Department issue a PIE? (a) If you are a service agent, the Department may issue a PIE concerning... also may issue a PIE if you have failed to cooperate with DOT agency representatives...

  9. Inhibition of transcription by the Caenorhabditis elegans germline protein PIE-1: genetic evidence for distinct mechanisms targeting initiation and elongation.

    PubMed

    Ghosh, Dolan; Seydoux, Geraldine

    2008-01-01

    In Caenorhabditis elegans embryos, specification of the germ lineage depends on PIE-1, a maternal protein that blocks mRNA transcription in germline blastomeres. Studies in mammalian cell culture have suggested that PIE-1 inhibits P-TEFb, a kinase that phosphorylates serine 2 in the carboxyl-terminal domain (CTD) repeats of RNA polymerase II during transcriptional elongation. We have tested this hypothesis using an in vivo complementation assay for PIE-1 function. Our results support the view that PIE-1 inhibits P-TEFb using the CTD-like motif YAPMAPT. This activity is required to block serine 2 phosphorylation in germline blastomeres, but unexpectedly is not essential for transcriptional repression or specification of the germline. We find that sequences outside of the YAPMAPT are required to inhibit serine 5 phosphorylation, and that this second inhibitory mechanism is essential for transcriptional repression and specification of the germ lineage. Our results suggest that PIE-1 uses partially redundant mechanisms to block transcription by targeting both the initiation and elongation phases of the transcription cycle.

  10. First Images from the 74 MHz VLA - Pie Town Link

    NASA Astrophysics Data System (ADS)

    Lane, W. M.; Cohen, A. S.; Kassim, N. E.; Lazio, T. J. W.

    2005-12-01

    A 74 MHz (4m wavelength) receiver has now been added to the VLBA antenna at Pie Town, bringing the full resolving power of the VLA + Pie Town Link to this low frequency. With baselines up to 73 km, corresponding to resolutions of ˜10 arcsec, and sensitivities ˜20 mJy bm-1, the first observations shown here have achieved by far the highest resolution and sensitivity of any images at this frequency to date.

  11. A LTA flight research vehicle. [technology assessment, airships

    NASA Technical Reports Server (NTRS)

    Nebiker, F. R.

    1975-01-01

    An Airship Flight Research Program is proposed. Major program objectives are summarized and a Modernized Navy ZPG3W Airship recommended as the flight test vehicle. The origin of the current interest in modern airship vehicles is briefly discussed and the major benefits resulting from the flight research program described. Airship configurations and specifications are included.

  12. Analysis of migration rate and chemotaxis of human adipose-derived mesenchymal stem cells in response to LPS and LTA in vitro.

    PubMed

    Herzmann, Nicole; Salamon, Achim; Fiedler, Tomas; Peters, Kirsten

    2016-03-15

    Mesenchymal stem cells (MSC) are able to stimulate the regeneration of injured tissue. Since bacterial infections are common complications in wound healing, bacterial pathogens and their components come into direct contact with MSC. The interaction with bacterial structures influences the proliferation, differentiation and migratory activity of the MSC, which might be of relevance during regeneration. Studies on MSC migration in response to bacterial components have shown different results depending on the cell type. Here, we analyzed the migration rate and chemotaxis of human adipose-derived MSC (adMSC) in response to the basic cell-wall components lipopolysaccharide (LPS) of Gram-negative bacteria and lipoteichoic acid (LTA) of Gram-positive bacteria in vitro. To this end, we used transwell and scratch assays, as well as a specific chemotaxis assay combined with live-cell imaging. We found no significant influence of LPS or LTA on the migration rate of adMSC in transwell or scratch assays. Furthermore, in the µ-slide chemotaxis assay, the stimulation with LPS did not exert any chemotactic effect on adMSC.

  13. Low pH Environmental Stress Inhibits LPS and LTA-Stimulated Proinflammatory Cytokine Production in Rat Alveolar Macrophages

    PubMed Central

    Fernandez, Stanley F.; Fung, Christopher; Helinski, Jadwiga D.; Alluri, Ravi; Davidson, Bruce A.; Knight, Paul R.

    2013-01-01

    Gastric aspiration increases the risks for developing secondary bacterial pneumonia. Cytokine elaboration through pathogen recognition receptors (PRRs) is an important mechanism in initiating innate immune host response. Effects of low pH stress, a critical component of aspiration pathogenesis, on the PRR pathways were examined, specifically toll-like receptor-2 (TLR2) and TLR4, using isolated rat alveolar macrophages (aMØs). We assessed the ability of aMØs after brief exposure to acidified saline to elaborate proinflammatory cytokines in response to lipopolysaccharide (LPS) and lipoteichoic acid (LTA) stimulation, known ligands of TLR4 and TLR2, respectively. Low pH stress reduced LPS- and LTA-mediated cytokine release (CINC-1, MIP-2, TNF-α, MCP-1, and IFN-β). LPS and LTA increased intracellular Ca2+ concentrations while Ca2+ chelation by BAPTA decreased LPS- and LTA-mediated cytokine responses. BAPTA blocked the effects of low pH stress on most of LPS-stimulated cytokines but not of LTA-stimulated responses. In vivo mouse model demonstrates suppressed E. coli and S. pneumoniae clearance following acid aspiration. In conclusion, low pH stress inhibits antibacterial cytokine response of aMØs due to impaired TLR2 (MyD88 pathway) and TLR4 signaling (MyD88 and TRIF pathways). The role of Ca2+ in low pH stress-induced signaling is complex but appears to be distinct between LPS- and LTA-mediated responses. PMID:24288685

  14. 49 CFR 40.409 - What does the issuance of a PIE mean to transportation employers?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false What does the issuance of a PIE mean to... What does the issuance of a PIE mean to transportation employers? (a) As an employer, you are deemed to have notice of the issuance of a PIE when it appears on the List mentioned in § 40.401(a) or the...

  15. 49 CFR 40.395 - Can you settle a PIE proceeding?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Can you settle a PIE proceeding? 40.395 Section 40... DRUG AND ALCOHOL TESTING PROGRAMS Public Interest Exclusions § 40.395 Can you settle a PIE proceeding... concurrence, settle a PIE proceeding....

  16. 49 CFR 40.383 - What procedures apply if you contest the issuance of a PIE?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false What procedures apply if you contest the issuance of a PIE? 40.383 Section 40.383 Transportation Office of the Secretary of Transportation PROCEDURES... What procedures apply if you contest the issuance of a PIE? (a) DOT conducts PIE proceedings in a...

  17. 49 CFR 40.397 - When does the Director make a PIE decision?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false When does the Director make a PIE decision? 40.397... a PIE decision? The Director makes his or her decision within 60 days of the date when the record of a PIE proceeding is complete (including any meeting with the Director and any additional...

  18. Personalized Information Environments: Do Public Libraries Want a Slice of the PIE?

    ERIC Educational Resources Information Center

    Worcester, Lea

    2003-01-01

    Discussion of personalized information environments (PIEs) focuses on library personalized interfaces. Describes academic library PIEs and commercial sites, such as Amazon.com that use personalization; explores the Public Library of Charlotte and Mecklenburg's personalized interface; and discusses opportunities and challenges PIEs offer public…

  19. 49 CFR 40.385 - Who bears the burden of proof in a PIE proceeding?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 1 2014-10-01 2014-10-01 false Who bears the burden of proof in a PIE proceeding... TRANSPORTATION WORKPLACE DRUG AND ALCOHOL TESTING PROGRAMS Public Interest Exclusions § 40.385 Who bears the burden of proof in a PIE proceeding? (a) As the proponent of issuing a PIE, the initiating official...

  20. 49 CFR 40.385 - Who bears the burden of proof in a PIE proceeding?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 1 2013-10-01 2013-10-01 false Who bears the burden of proof in a PIE proceeding... TRANSPORTATION WORKPLACE DRUG AND ALCOHOL TESTING PROGRAMS Public Interest Exclusions § 40.385 Who bears the burden of proof in a PIE proceeding? (a) As the proponent of issuing a PIE, the initiating official...

  1. 49 CFR 40.385 - Who bears the burden of proof in a PIE proceeding?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 1 2011-10-01 2011-10-01 false Who bears the burden of proof in a PIE proceeding... TRANSPORTATION WORKPLACE DRUG AND ALCOHOL TESTING PROGRAMS Public Interest Exclusions § 40.385 Who bears the burden of proof in a PIE proceeding? (a) As the proponent of issuing a PIE, the initiating official...

  2. 49 CFR 40.385 - Who bears the burden of proof in a PIE proceeding?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Who bears the burden of proof in a PIE proceeding... TRANSPORTATION WORKPLACE DRUG AND ALCOHOL TESTING PROGRAMS Public Interest Exclusions § 40.385 Who bears the burden of proof in a PIE proceeding? (a) As the proponent of issuing a PIE, the initiating official...

  3. 49 CFR 40.385 - Who bears the burden of proof in a PIE proceeding?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 1 2012-10-01 2012-10-01 false Who bears the burden of proof in a PIE proceeding... TRANSPORTATION WORKPLACE DRUG AND ALCOHOL TESTING PROGRAMS Public Interest Exclusions § 40.385 Who bears the burden of proof in a PIE proceeding? (a) As the proponent of issuing a PIE, the initiating official...

  4. Optical and structural studies of CuI clusters in zeolites LTA and FAU

    NASA Astrophysics Data System (ADS)

    Kodaira, Tetsuya; Ikeda, Takuji

    2006-05-01

    CuI clusters were incorporated into α-cages and supercages of zeolites LTA and FAU, respectively, with various loading densities. From the powder XRD measurement of CuI clusters in FAU, it can be concluded that CuI clusters with homogeneous size were distributed in the cages. In case of using FAU as a host, when the loading density became close to the maximum, photo absorption intensity gradually decreased. A polariton effect, i.e. photo excited energy transfers among the clusters, may play an important role on this phenomenon. Cu and I atoms of bulk CuI crystal have tetrahedral chemical bondings. Supercages of FAU have an arrangement of a diamond structure. Coincidence on the symmetry of the chemical bondings in the CuI clusters and the arrangement of the clusters in the supercages may be the origin of a highly ordered state of CuI clusters and will enhance the polariton effect.

  5. High performance zeolite LTA pervaporation membranes on ceramic hollow fibers by dipcoating-wiping seed deposition.

    PubMed

    Wang, Zhengbao; Ge, Qinqin; Shao, Jia; Yan, Yushan

    2009-05-27

    We demonstrate for the first time that by one single hydrothermal synthesis a zeolite LTA membrane with a high flux of 9.0 kg/m(2) h and high water/ethanol separation factor of 10,000 could be formed on a ceramic hollow fiber that is known for its ability to form a compact module. The flux is the highest reported in the literatures. A novel seeding method, dipcoating-wiping, is key to obtaining zeolite membranes with high separation performance because it reproducibly produces a uniform and trace seed layer on the support. This new seeding method is expected to have serious implications for making defect-free zeolite films and membranes for many applications. The membranes reported here have the potential to solve the key problems that have prevented zeolite membranes from widespread use for biofuel production.

  6. Two-Person Pie-Cutting: The Fairest Cuts

    ERIC Educational Resources Information Center

    Barbanel, Julius B.; Brams, Steven J.

    2011-01-01

    Barbanel, Brams, and Stromquist (in 2009) asked whether there exists a two-person moving-knife procedure that yields an envy-free, undominated, and equitable division of a pie. We present two procedures: One yields an envy-free, almost undominated, and almost equitable allocation, whereas the second yields an allocation with the two "almost"…

  7. 9 CFR 381.158 - Poultry dinners (frozen) and pies.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 2 2012-01-01 2012-01-01 false Poultry dinners (frozen) and pies. 381... AGRICULTURE AGENCY ORGANIZATION AND TERMINOLOGY; MANDATORY MEAT AND POULTRY PRODUCTS INSPECTION AND VOLUNTARY INSPECTION AND CERTIFICATION POULTRY PRODUCTS INSPECTION REGULATIONS Definitions and Standards of Identity...

  8. 9 CFR 381.158 - Poultry dinners (frozen) and pies.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 2 2013-01-01 2013-01-01 false Poultry dinners (frozen) and pies. 381... AGRICULTURE AGENCY ORGANIZATION AND TERMINOLOGY; MANDATORY MEAT AND POULTRY PRODUCTS INSPECTION AND VOLUNTARY INSPECTION AND CERTIFICATION POULTRY PRODUCTS INSPECTION REGULATIONS Definitions and Standards of Identity...

  9. 9 CFR 381.158 - Poultry dinners (frozen) and pies.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 2 2014-01-01 2014-01-01 false Poultry dinners (frozen) and pies. 381... AGRICULTURE AGENCY ORGANIZATION AND TERMINOLOGY; MANDATORY MEAT AND POULTRY PRODUCTS INSPECTION AND VOLUNTARY INSPECTION AND CERTIFICATION POULTRY PRODUCTS INSPECTION REGULATIONS Definitions and Standards of Identity...

  10. 9 CFR 381.158 - Poultry dinners (frozen) and pies.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Poultry dinners (frozen) and pies. 381... AGRICULTURE AGENCY ORGANIZATION AND TERMINOLOGY; MANDATORY MEAT AND POULTRY PRODUCTS INSPECTION AND VOLUNTARY INSPECTION AND CERTIFICATION POULTRY PRODUCTS INSPECTION REGULATIONS Definitions and Standards of Identity...

  11. 9 CFR 381.158 - Poultry dinners (frozen) and pies.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Poultry dinners (frozen) and pies. 381... AGRICULTURE AGENCY ORGANIZATION AND TERMINOLOGY; MANDATORY MEAT AND POULTRY PRODUCTS INSPECTION AND VOLUNTARY INSPECTION AND CERTIFICATION POULTRY PRODUCTS INSPECTION REGULATIONS Definitions and Standards of Identity...

  12. Effect of TNF and LTA polymorphisms on biological markers of response to oxidative stimuli in coal miners: a model of gene-environment interaction

    PubMed Central

    Nadif, R; Jedlicka, A; Mintz, M; Bertrand, J; Kleeberger, S; Kauffmann, F

    2003-01-01

    Introduction: Interaction between genetic background and oxidative environmental stimuli in the pathogenesis of human lung disease has been largely unexplored. Methods: A prospective epidemiological study was undertaken in 253 coal miners. Intermediate quantitative phenotypes of response to oxidant exposure, including erythrocyte glutathione peroxidase (GSH-Px) and catalase activities, were studied. Oxidant exposures studied were smoking habits and cumulative dust exposure assessed by job history and ambient measures. Disease phenotypes included subclinical computed tomography score at the first survey and x ray profusion grades twice, five years apart, to assess established coal workers' pneumoconiosis (CWP). Miners were genotyped for common functional polymorphisms in the gene for tumour necrosis factor α (TNF) and lymphotoxin α (LTA), two proinflammatory cytokines that have been implicated in the pathogenesis of chronic lung diseases. Results: Regarding gene-environment interaction on intermediate phenotypes, results showed interaction of a promoter polymorphism at the –308 position in TNF with occupational exposure on erythrocyte GSH-Px activity with a significant association in those with high exposure (p=0.003), whereas no association was observed among those with low exposure (interaction p=0.06). Regarding gene intermediate phenotype interaction on clinical outcome, results showed an association of CWP prevalence with an NcoI polymorphism in LTA in those with low catalase activity (p=0.05), whereas no association was observed in those with high activity (interaction p=0.03). No other significant association was observed. Conclusion: The results suggest that interactions of genetic background with environmental exposure and intermediate response phenotypes are important components in the pathogenesis of CWP. PMID:12566517

  13. 49 CFR 40.407 - May a service agent ask to have a PIE reduced or terminated?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false May a service agent ask to have a PIE reduced or... agent ask to have a PIE reduced or terminated? (a) Yes, as a service agent concerning whom the Department has issued a PIE, you may request that the Director terminate a PIE or reduce its duration...

  14. Decommissioning and PIE of the MEGAPIE spallation target

    SciTech Connect

    Latge, C.; Henry, J.; Wohlmuther, M.; Dai, Y.; Gavillet, D.; Hammer, B.; Heinitz, S.; Neuhausen, J.; Schumann, D.; Thomsen, K.; Tuerler, A.; Wagner, W.; Gessi, A.; Guertin, A.; Konstantinovic, M.; Lindau, R.; Maloy, S.; Saito, S.

    2013-07-01

    A key experiment in the Accelerated Driven Systems roadmap, the MEGAwatt PIlot Experiment (MEGAPIE) (1 MW) was initiated in 1999 in order to design and build a liquid lead-bismuth spallation target, then to operate it into the Swiss spallation neutron facility SINQ at Paul Scherrer Institute. The target has been designed, manufactured, and tested during integral tests, before irradiation carried out end of 2006. During irradiation, neutron and thermo hydraulic measurements were performed allowing deep interpretation of the experiment and validation of the models used during design phase. The decommissioning, Post Irradiation Examinations and waste management phases were defined properly. The phases dedicated to cutting, sampling, cleaning, waste management, samples preparation and shipping to various laboratories were performed by PSI teams: all these phases constitute a huge work, which allows now to perform post-irradiation examination (PIE) of structural material, irradiated in relevant conditions. Preliminary results are presented in the paper, they concern chemical characterization. The following radio-nuclides have been identified by γ-spectrometry: {sup 60}Co, {sup 101}Rh, {sup 102}Rh, {sup 108m}Ag, {sup 110m}Ag, {sup 133}Ba, {sup 172}Hf/Lu, {sup 173}Lu, {sup 194}Hg/Au, {sup 195}Au, {sup 207}Bi. For some of these nuclides the activities can be easily evaluated from γ-spectrometry results ({sup 207}Bi, {sup 194}Hg/Au), while other nuclides can only be determined after chemical separations ({sup 108m}Ag, {sup 110m}Ag, {sup 195}Au, {sup 129}I, {sup 36}Cl and α-emitting {sup 208-210}Po). The concentration of {sup 129}I is lower than expected. The chemical analysis already performed on spallation and corrosion products in the lead-bismuth eutectic (LBE) are very relevant for further applications of LBE as a spallation media and more generally as a coolant.

  15. [The Projet PIE: a promising strategy to reach elders with a mental health problem].

    PubMed

    Nour, Kareen; Brown, Brita; Moscovitz, Nona; Hébert, Marijo; Regenstreif, Alan

    2009-01-01

    Approximately fifty percent of older adults with a mental health problem do not receive services. A proactive outreach strategy, Project PIE (Prevention-Intervention-Education) relies upon the assistance of non-traditional referral sources, namely community liaisons, to identify and refer to the CSSS vulnerable or isolated elders with a mental health problem. An evaluation of this project reveals encouraging results. The project appears useful, relevant and efficient to detect elders with a mental health problem and offer the required assistance. This project also appears to be a means to foster social solidarity.

  16. OpenMP for 3D potential boundary value problems solved by PIES

    NASA Astrophysics Data System (ADS)

    KuŻelewski, Andrzej; Zieniuk, Eugeniusz

    2016-06-01

    The main purpose of this paper is examination of an application of modern parallel computing technique OpenMP to speed up the calculation in the numerical solution of parametric integral equations systems (PIES). The authors noticed, that solving more complex boundary problems by PIES sometimes requires large computing time. This paper presents the use of OpenMP and fast C++ linear algebra library Armadillo for boundary value problems modelled by 3D Laplace's equation and solved using PIES. The testing example shows that the use of mentioned technologies significantly increases speed of calculations in PIES.

  17. Slow improvements of metal exposure, health- and breeding conditions of pied flycatchers (Ficedula hypoleuca) after decreased industrial heavy metal emissions.

    PubMed

    Berglund, A M M; Nyholm, N E I

    2011-09-15

    The environment around metal industries, such as smelters, is often highly contaminated due to continuous deposition of metals. We studied nest box breeding populations of pied flycatchers (Ficedula hypoleuca) in a well-studied pollution gradient from a sulfide ore smelter in Northern Sweden, after reduced aerial metal emissions (by 93-99%) from the smelter. The deposition of arsenic, cadmium, copper and zinc (based on moss samples) reflected the reduced emissions fairly well. However, nestling pied flycatchers had similar concentrations of these elements and mercury in tissues (bone, liver and blood) and feces in the 2000s, as in the 1980s, when the emissions were substantially higher. The exposure to high metal concentrations in the close vicinity of the smelter resulted in inhibited ALAD activities, depressed hemoglobin and hematocrit levels and increased mortality of nestlings. Our results indicate that in the highly contaminated environment around the smelter, nestlings reflected the slowly cycling soil pool, rather than the atmospheric deposition, and the concentration in soils plays an important role for the response of pied flycatchers to reduced atmospheric deposition.

  18. Development of the Persistence in Engineering (PIE) Survey Instrument. Research Brief

    ERIC Educational Resources Information Center

    Eris, Ozgur; Chen, Helen; Bailey, Tori; Engerman, Kimarie; Loshbaugh, Heidi; Griffin, Ashley; Lichtenstein, Gary; Cole, Angela

    2007-01-01

    The Persistence In Engineering (PIE) survey was developed to identify and characterize the fundamental factors that influence students' intentions to pursue an engineering degree over the course of their undergraduate career, and upon graduation, to practice engineering as a profession. The PIE survey is one of five data-gathering methods used in…

  19. 49 CFR 40.393 - How long does a PIE stay in effect?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false How long does a PIE stay in effect? 40.393 Section... WORKPLACE DRUG AND ALCOHOL TESTING PROGRAMS Public Interest Exclusions § 40.393 How long does a PIE stay in effect? (a) In the NOPE (see § 40.375(b)(5)), the initiating official proposes the duration of the...

  20. 49 CFR 40.387 - What matters does the Director decide concerning a proposed PIE?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... proposed PIE? 40.387 Section 40.387 Transportation Office of the Secretary of Transportation PROCEDURES FOR... the Director decide concerning a proposed PIE? (a) Following the service agent's response (see § 40... from the service agent (see § 40.379(b)(1)) or on his or her own motion, the Director may dismiss a...

  1. No Humble Pie: The Origins and Usage of a Statistical Chart

    ERIC Educational Resources Information Center

    Spence, Ian

    2005-01-01

    William Playfair's pie chart is more than 200 years old and yet its intellectual origins remain obscure. The inspiration likely derived from the logic diagrams of Llull, Bruno, Leibniz, and Euler, which were familiar to William because of the instruction of his mathematician brother John. The pie chart is broadly popular but--despite its common…

  2. 49 CFR 40.405 - May the Federal courts review PIE decisions?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false May the Federal courts review PIE decisions? 40.405 Section 40.405 Transportation Office of the Secretary of Transportation PROCEDURES FOR... courts review PIE decisions? The Director's decision is a final administrative action of the...

  3. Harnessing the Internet for International Exchanges on Learning Cities: The Pie Experience 2011-2013

    ERIC Educational Resources Information Center

    Kearns, Peter

    2014-01-01

    The PASCAL International Exchanges (PIE) project was developed to facilitate online exchanges of information and experience between learning cities around the world and, in doing this, to test the potential of the internet to enable such low-cost exchanges. The author provides a personal assessment of the PIE experience over the three years 2011…

  4. Relationship between human LTA4H polymorphisms and extra-pulmonary tuberculosis in an ethnic Han Chinese population in Eastern China.

    PubMed

    Yang, Jinghui; Chen, Jin; Yue, Jun; Liu, Lirong; Han, Min; Wang, Hongxiu

    2014-12-01

    Two single nucleotide polymorphisms in Leukotriene A4 hydrolase (LTA4H) gene were reported to be associated with protection from pulmonary tuberculosis in Vietnamese population. But these associations were not found in the Russians. To investigate the association of LTA4H polymorphisms with tuberculosis in a Han Chinese population in Eastern China, we genotyped 5 SNPs of LTA4H gene in 743 of pulmonary tuberculosis patients, 372 of extra-pulmonary tuberculosis patients and 888 of healthy controls individuals. The CC and TT homozygotes of rs1978331 and rs2540474 were identified to have higher rates (P < 0.01) and be risk factors in the patients with extra-pulmonary tuberculosis (OR = 1.412; 95% CI = 1.104-1.804 and(OR = 1.380; 95% CI = 1.080-1.764). However, no significant association was found between any of the SNPs and pulmonary tuberculosis. In the extra-pulmonary tuberculosis subgroups. LTA4H gene were significantly associated with tuberculous meningitis, lymph node tuberculosis, bone tuberculosis and other extra-pulmonary tuberculosis except for pleural tuberculosis. The present findings suggest that polymorphisms in the LTA4H gene may affect susceptibility to extra-pulmonary tuberculosis and change the risk of developing the disease in the Han nationality in the East China.

  5. Magnetic Resonance Imaging: A Tool for Pork Pie Development.

    PubMed

    Gaunt, Adam P; Morris, Robert H; Newton, Michael I

    2013-08-28

    The traditional British pork pie consists of roughly chopped pork cooked in a hot water pastry crust. Due to shrinkage of the meat during cooking, the gap formed around the meat is usually sealed using a gelatin based jelly to exclude air and thus help to preserve the pie. The properties of the jelly are such that it will ingress into the pastry crust causing undesirable softening. The jelly is traditionally produced by simmering pig trotters with seasoning for several hours. In this work we demonstrate the potential of magnetic resonance imaging (MRI) as a tool for investigating the conditions required for producing jellies with different properties and present two examples of this use. Firstly we demonstrate that MRI can determine the ability of water to diffuse through the jelly which is critical in minimizing the amount of moisture moving from the jelly to the crust. Secondly, the impact of jelly temperature on the penetration length into the crust is investigated. These examples highlight the power of MRI as a tool for food assessment.

  6. Introducing a Framework for Physics Innovation and Entrepreneurship (PIE) Education

    NASA Astrophysics Data System (ADS)

    Roughani, Bahram

    A desired outcome for Physics Innovation and Entrepreneurship (PIE) education is preparing physics majors with an innovative and entrepreneurial mindset who are capable of opportunity recognition and adept in leveraging physics knowledge to address specific needs. Physics as a discipline is well-recognized to prepare students who become problem solvers and critical thinkers, gifted in dealing with abstract ideas and ambiguities in the context of complex and real-world problems. These characteristics when enhanced through appropriate combinations of curricular, co-curricular, and extra-curricular programs can prepare physics majors for careers and future challenges that may involve translating physics knowledge into useful products and services either as part of a technical team within an organization or through startups. A viable PIE education model prepares graduates for various career paths in addition to the traditional options such as pursuing graduate studies or becoming a science teacher. Having a well-defined ``third option'' for physics will benefit the robustness of the physics discipline through recruitment and retention of prospective students who in principle are interested in physics as a subject, but in practice they may overlook physics as their preferred major primarily because they are uncertain about a viable career path based on an undergraduate physics education. The ''Pathways to Innovation'' at Loyola is established based on the program developed by VentureWell and Epicenter (NSF Supported).

  7. Random allocation of pies promotes the evolution of fairness in the Ultimatum Game

    PubMed Central

    Wang, Xiaofeng; Chen, Xiaojie; Wang, Long

    2014-01-01

    In the Ultimatum Game, two players are offered a chance to win a pie. The proposer suggests how to split the pie. The responder can either accept or reject the deal. If an agreement is not reached, neither player gets anything. Both game theory and evolutionary game theory predict the rational solution that the proposer offers the smallest possible share and the responder accepts it. Fairness thus requires additional mechanisms for natural selection to favor it. Studies to date assumed that individuals have competed for the fixed size of pies, in sharp contrast with real situations, where randomness is ubiquitous. Here we study the impact of random allocation of pies on the evolution of fairness in the Ultimatum Game. Interestingly, we find that the evolution of fairness can be promoted by the randomness associated with the size of pies, without the support of any additional evolutionary mechanisms. PMID:24686840

  8. 49 CFR 40.381 - What information do you present to contest the proposed issuance of a PIE?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... proposed issuance of a PIE? 40.381 Section 40.381 Transportation Office of the Secretary of Transportation... What information do you present to contest the proposed issuance of a PIE? (a) As a service agent who wants to contest a proposed PIE, you must present at least the following information to the Director:...

  9. 49 CFR 40.403 - Must a service agent notify its clients when the Department issues a PIE?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Department issues a PIE? 40.403 Section 40.403 Transportation Office of the Secretary of Transportation... Must a service agent notify its clients when the Department issues a PIE? (a) As a service agent, if the Department issues a PIE concerning you, you must notify each of your DOT-regulated...

  10. 49 CFR 40.401 - How does the Department notify employers and the public about a PIE?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... public about a PIE? 40.401 Section 40.401 Transportation Office of the Secretary of Transportation... How does the Department notify employers and the public about a PIE? (a) The Department maintains a.... (b) When the Director issues a PIE, he or she adds to the List the name and address of the...

  11. Incorporation of AgI clusters into the cages of zeolites LTA and FAU observed by optical spectra and X-ray diffraction patterns

    NASA Astrophysics Data System (ADS)

    Kodaira, Tetsuya; Ikeda, Takuji; Takeo, Harutoshi

    1999-02-01

    The loading of AgI into the cages of zeolites LTA and FAU was performed by vapor-phase adsorption. The successful incorporation of AgI clusters into the cages was confirmed by optical absorption spectra and X-ray powder diffraction patterns. Large blue shifts of the absorption edges were observed in the spectra of adsorbed AgI to both zeolites, compared with the lowest excited state of AgI in the bulk. The present observation of the shift implies that a strong quantum confinement in the photoexcited state of AgI occurs, which leads to the conclusion that AgI clusters have been formed in the cages. In the X-ray powder diffraction pattern of AgI-loaded LTA, superlattice reflection peaks are observed which cannot be assigned either to the reflection of LTA or the AgI in the bulk.

  12. Temperature-Dependent Electrical Conductivity Measurements on Hydrated and Alkali-metal Intercalated Zeolite LTA and FAU

    NASA Astrophysics Data System (ADS)

    Yumoto, Kenji; Suzuki, Yoshinori; Wada, Noboru

    2007-03-01

    Zeolite LTA and FAU films were made from zeolite powders using a hydrothermal method. Electrical conductivity measurement were performed on the zeolite films in temperature range between 180 K and 430 K, using an LCR meter with the sweeping frequency varied from 20 to 1 MHz and drawing the Cole-Cole plots. The resistivities of both hydrated LTA and FAU zeolites increased with increasing the sample temperature from RT to 430 K, which might be caused by loss of water molecules from the pores of zeolite crystals. Also, the resistivities increased with decreasing the sample temperature from RT to 180 K, probably caused by freezing of water molecules in the zeolite. When the dehydrated zeolite samples were intercalated with alkali metals (Rb and K), the resistivities of the samples did not vary much at RT. However, the resistivities of the intercalated zeolite films decreased drastically by four orders of magnitude when the sample temperature was varied from RT to 180 K. We speculate that the dynamics of alkali atoms in the zeolite pores (electron-phonon scattering) may be responsible for the drastic change in the electrical conductivity.

  13. Lipoteichoic Acid (LTA) and Lipopolysaccharides (LPS) from Periodontal Pathogenic Bacteria Facilitate Oncogenic Herpesvirus Infection within Primary Oral Cells

    PubMed Central

    Dai, Lu; DeFee, Michael R.; Cao, Yueyu; Wen, Jiling; Wen, Xiaofei; Noverr, Mairi C.; Qin, Zhiqiang

    2014-01-01

    Kaposi’s sarcoma (KS) remains the most common tumor arising in patients with HIV/AIDS, and involvement of the oral cavity represents one of the most common clinical manifestations of this tumor. HIV infection incurs an increased risk for periodontal diseases and oral carriage of a variety of bacteria. Whether interactions involving pathogenic bacteria and oncogenic viruses in the local environment facilitate replication or maintenance of these viruses in the oral cavity remains unknown. In the current study, our data indicate that pretreatment of primary human oral fibroblasts with two prototypical pathogen-associated molecular patterns (PAMPs) produced by oral pathogenic bacteria–lipoteichoic acid (LTA) and lipopolysaccharide (LPS), increase KSHV entry and subsequent viral latent gene expression during de novo infection. Further experiments demonstrate that the underlying mechanisms induced by LTA and/or LPS include upregulation of cellular receptor, increasing production of reactive oxygen species (ROS), and activating intracellular signaling pathways such as MAPK and NF-κB, and all of which are closely associated with KSHV entry or gene expression within oral cells. Based on these findings, we hope to provide the framework of developing novel targeted approaches for treatment and prevention of oral KSHV infection and KS development in high-risk HIV-positive patients. PMID:24971655

  14. Statement-Pie: a strategy to improve the paragraph writing skills of adolescents with learning disabilities.

    PubMed

    Wallace, G W; Bott, D A

    1989-11-01

    This study investigated the effects of teaching a metacognitive text structure strategy upon the paragraph writing skills of eighth-grade students with learning disabilities. The technique, called Statement-Pie (Hanau, 1974), teaches students to understand the relationship of supporting details to a main idea. Four students were taught to use an outline as a paragraph planning guide, which they then used to convert information into written expository paragraphs. All subjects reached instructional outcome criterion on the writing of comparison/contrast and sequence paragraphs. One week after reaching mastery in the special education classroom, students generalized their paragraph writing skills to other teachers and to different classrooms. The results of this investigation indicate that when provided with direct, intensive instruction in a text structure strategy, adolescents with learning disabilities can improve their skills in paragraph writing.

  15. Variable step size and order strategy for delay differential equations in PIE(CIE)s mode

    NASA Astrophysics Data System (ADS)

    Aziz, Nurul Huda Abdul; Majid, Zanariah Abdul

    2014-12-01

    This article deals with the strategy of variable step size and variable order implementation that has been formulated for solving first order of delay differential equations. This strategy is adapted in PIE(CIE)s mode which is generally based on predictor-corrector scheme in multistep block method of order 4 to 9 with s is for convergence test. The purpose here is to enhance the efficiency of the developed predictor-corrector algorithm in the capability to vary automatically not only for the step size, but the order of the method employed as well. All order and coefficients are stored in the code in order to avoid an expensive computational work. The delay argument would be evaluated using Newton divided-difference interpolation at which the points involved would be similar to the current order of the method. Illustrative examples are included to demonstrate the validity and applicability of the presented strategy and comparison is made with the existing results.

  16. Structural Conservation and Functional Diversity of the Poxvirus Immune Evasion (PIE) Domain Superfamily.

    PubMed

    Nelson, Christopher A; Epperson, Megan L; Singh, Sukrit; Elliott, Jabari I; Fremont, Daved H

    2015-08-28

    Poxviruses encode a broad array of proteins that serve to undermine host immune defenses. Structural analysis of four of these seemingly unrelated proteins revealed the recurrent use of a conserved beta-sandwich fold that has not been observed in any eukaryotic or prokaryotic protein. Herein we propose to call this unique structural scaffolding the PIE (Poxvirus Immune Evasion) domain. PIE domain containing proteins are abundant in chordopoxvirinae, with our analysis identifying 20 likely PIE subfamilies among 33 representative genomes spanning 7 genera. For example, cowpox strain Brighton Red appears to encode 10 different PIEs: vCCI, A41, C8, M2, T4 (CPVX203), and the SECRET proteins CrmB, CrmD, SCP-1, SCP-2, and SCP-3. Characterized PIE proteins all appear to be nonessential for virus replication, and all contain signal peptides for targeting to the secretory pathway. The PIE subfamilies differ primarily in the number, size, and location of structural embellishments to the beta-sandwich core that confer unique functional specificities. Reported ligands include chemokines, GM-CSF, IL-2, MHC class I, and glycosaminoglycans. We expect that the list of ligands and receptors engaged by the PIE domain will grow as we come to better understand how this versatile structural architecture can be tailored to manipulate host responses to infection.

  17. Structural Conservation and Functional Diversity of the Poxvirus Immune Evasion (PIE) Domain Superfamily

    PubMed Central

    Nelson, Christopher A.; Epperson, Megan L.; Singh, Sukrit; Elliott, Jabari I.; Fremont, Daved H.

    2015-01-01

    Poxviruses encode a broad array of proteins that serve to undermine host immune defenses. Structural analysis of four of these seemingly unrelated proteins revealed the recurrent use of a conserved beta-sandwich fold that has not been observed in any eukaryotic or prokaryotic protein. Herein we propose to call this unique structural scaffolding the PIE (Poxvirus Immune Evasion) domain. PIE domain containing proteins are abundant in chordopoxvirinae, with our analysis identifying 20 likely PIE subfamilies among 33 representative genomes spanning 7 genera. For example, cowpox strain Brighton Red appears to encode 10 different PIEs: vCCI, A41, C8, M2, T4 (CPVX203), and the SECRET proteins CrmB, CrmD, SCP-1, SCP-2, and SCP-3. Characterized PIE proteins all appear to be nonessential for virus replication, and all contain signal peptides for targeting to the secretory pathway. The PIE subfamilies differ primarily in the number, size, and location of structural embellishments to the beta-sandwich core that confer unique functional specificities. Reported ligands include chemokines, GM-CSF, IL-2, MHC class I, and glycosaminoglycans. We expect that the list of ligands and receptors engaged by the PIE domain will grow as we come to better understand how this versatile structural architecture can be tailored to manipulate host responses to infection. PMID:26343707

  18. Use of Formative Assessment, Self- and Peer-Assessment in the Classrooms: Some Insights from Recent Language Testing and Assessment (LTA) Research

    ERIC Educational Resources Information Center

    Afitska, Oksana

    2014-01-01

    A considerable number of studies on formative teacher assessment and feedback, learner self- and peer-assessment have been carried out in the field of Language Testing and Assessment (LTA) research over the last two decades. These studies investigated the above mentioned concepts from different perspectives (impact of assessment on learning,…

  19. The Canonical Immediate Early 3 Gene Product pIE611 of Mouse Cytomegalovirus Is Dispensable for Viral Replication but Mediates Transcriptional and Posttranscriptional Regulation of Viral Gene Products

    PubMed Central

    Rattay, Stephanie; Trilling, Mirko; Megger, Dominik A.; Sitek, Barbara; Meyer, Helmut E.; Hengel, Hartmut

    2015-01-01

    ABSTRACT Transcription of mouse cytomegalovirus (MCMV) immediate early ie1 and ie3 is controlled by the major immediate early promoter/enhancer (MIEP) and requires differential splicing. Based on complete loss of genome replication of an MCMV mutant carrying a deletion of the ie3-specific exon 5, the multifunctional IE3 protein (611 amino acids; pIE611) is considered essential for viral replication. Our analysis of ie3 transcription resulted in the identification of novel ie3 isoforms derived from alternatively spliced ie3 transcripts. Construction of an IE3-hemagglutinin (IE3-HA) virus by insertion of an in-frame HA epitope sequence allowed detection of the IE3 isoforms in infected cells, verifying that the newly identified transcripts code for proteins. This prompted the construction of an MCMV mutant lacking ie611 but retaining the coding capacity for the newly identified isoforms ie453 and ie310. Using Δie611 MCMV, we demonstrated the dispensability of the canonical ie3 gene product pIE611 for viral replication. To determine the role of pIE611 for viral gene expression during MCMV infection in an unbiased global approach, we used label-free quantitative mass spectrometry to delineate pIE611-dependent changes of the MCMV proteome. Interestingly, further analysis revealed transcriptional as well as posttranscriptional regulation of MCMV gene products by pIE611. IMPORTANCE Cytomegaloviruses are pathogenic betaherpesviruses persisting in a lifelong latency from which reactivation can occur under conditions of immunosuppression, immunoimmaturity, or inflammation. The switch from latency to reactivation requires expression of immediate early genes. Therefore, understanding of immediate early gene regulation might add insights into viral pathogenesis. The mouse cytomegalovirus (MCMV) immediate early 3 protein (611 amino acids; pIE611) is considered essential for viral replication. The identification of novel protein isoforms derived from alternatively spliced ie3

  20. Percutaneous quadriceps tendon pie-crusting release of extension contracture of the knee.

    PubMed

    Liu, H X; Wen, H; Hu, Y Z; Yu, H C; Pan, X Y

    2014-05-01

    To release extension contracture of the knee, the authors used a minimally invasive technique: percutaneous quadriceps tendon pie-crusting release. Percutaneous pie-crusting release was performed using an 18-gauge needle to puncture the stiff fibrous band of the distal and lateral quadriceps tendon under maximum knee flexion. Quadriceps contracture was gradually released by multiple needle punctures. A knee brace was prescribed for one week and knee flexion exercises were performed on the first postoperative day. This technique was performed in seven post-traumatic stiff knees and five stiff total knee arthroplasties. Mean maximum flexion increased from 37° preoperatively to 50° after arthrolysis and 107(o) after pie-crusting. At a mean follow-up of eight months, mean maximum flexion was 103°. There were no major complications. The technique of quadriceps tendon pie-crusting release is a simple, minimally invasive and effective treatment for knee extension contracture.

  1. 49 CFR 40.395 - Can you settle a PIE proceeding?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... DRUG AND ALCOHOL TESTING PROGRAMS Public Interest Exclusions § 40.395 Can you settle a PIE proceeding? At any time before the Director's decision, you and the initiating official can, with the...

  2. Captive breeding and reintroduction of the oriental pied hornbill (Anthracoceros albirostris) in Khao Kheow Open Zoo, Thailand.

    PubMed

    Chaiyarat, Rattanawat; Kongprom, Urarikha; Manathamkamon, Darika; Wanpradab, Sunan; Sangarang, Satean

    2012-01-01

    This article discusses two related issues of the captive breeding and reintroduction of the Oriental pied hornbill (Anthracoceros albirostris) in order to increase its population in the natural habitats. Oriental pied hornbills were bred in Khao Kheow Open Zoo. Three pairs were separated and kept in breeding cages. Females occupied artificial nests between February and April 2005-2007. Eggs were laid and incubated between February and March each year from 2005 to 2007. Nestlings hatched in late March and left the nest in late April 2005-2007. Each breeding pair was fed with approximately 400 g of food each day. All three pairs reproduced resulting in mature offspring of seven in 2005, six in 2006, and five in 2007. Four of sixteen 3-year-old birds were randomly selected and equipped with a GPS receiver on their backs. Activities of the birds attached and unattached with GPS were not significantly different. The first two birds (one female, one male with GPS) were reintroduced on August 5, 2006, and another nine birds (four birds with GPS) were reintroduced on December 26, 2006. The average home range of these reintroduced birds was 0.13 km(2) . Their foods consisted of wild plants and animals in the home range. The first reintroduced pair was able to breed naturally by laying and hatching eggs in an artificial nest. Two juveniles left the nest in April 2008. These results indicate that both captive breeding and reintroduction are potentially important ways to increase the population of the Oriental pied hornbill in natural habitats.

  3. Report on FY16 Low-dose Metal Fuel Irradiation and PIE

    SciTech Connect

    Edmondson, Philip D.

    2016-09-01

    This report gives an overview of the efforts into the low-dose metal fuel irradiation and PIE as part of the Fuel Cycle Research & Development (FCRD) Advanced Fuels Campaign (AFC) milestone M3FT-16OR020303031. The current status of the FCT and FCRP irradiation campaigns are given including a description of the materials that have been irradiated, analysis of the passive temperature monitors, and the initial PIE efforts of the fuel samples.

  4. Heat and Ice in Sermilik Fjord: Novel Observational Techniques Using PIES

    NASA Astrophysics Data System (ADS)

    Andres, M.; Straneo, F.; Sutherland, D.

    2014-12-01

    A 1-year pilot experiment using pressure-sensor-equipped inverted echo sounders (PIES) was conducted in Sermilik Fjord in eastern Greenland to test non-traditional methods for measuring the time-varying
heat content in high-latitude seas, shelves, and fjords and for detecting the presence of ice. PIES, which are installed on the seafloor below the reach of destructive iceberg keels, present
a promising and inexpensive way to improve understanding of fjord dynamics and shelf-fjord interactions and will increase long-term monitoring capabilities in high latitudes where
remoteness and harsh conditions hamper traditional in situ observation techniques. The use
of PIES to characterize variability at high latitudes is a novel application of an existing
technology, but rests on the same principle as the traditional blue-water uses for PIES: due
to the dependence of sound speed on temperature, the surface-to-bottom round-trip acoustic-travel-time associated with reflections between the PIES and the air-sea interface is an excellent proxy
for heat content in the intervening water column. Furthermore, since reflections from seawater-ice interfaces are also detected when ice
is present, PIES provide a means to characterize the ice component in high-latitude systems. The PIES deployed in Sermilik Fjord (August 2011 - September 2012) resolved changes in heat content at scales ranging from hourly to seasonal. Furthermore, during winter, the PIES logged about 300 iceberg detections and recorded a 2-week period of land-fast ice cover in March. The deepest icebergs in the fjord were found to have keel depths reaching to ~350 m and iceberg speeds averaged about 0.2 m/s but were as high as 0.5 m/s.

  5. An Assessment of ORNL PIE Capabilities for the AGR Program Capsule Post Irradiation Examination

    SciTech Connect

    Morris, Robert Noel

    2006-09-01

    ORNL has facilities and experienced staff that can execute +the Advanced Gas Reactor (AGR) Post Irradiation Examination (PIE) task. While the specific PIE breakdown needs to be more formally defined, the basic outline is clear and the existing capabilities can be assessed within the needs of the tasks defined in the program plan. A one-to-one correspondence between the program plan tasks and the current ORNL PIE status was conducted and while some shortcomings were identified, the general capability is available. Specific upgrade needs were identified and reviewed. A path forward was formulated. Building 3525 is available for this work and this building is currently receiving renewed attention from management so that it will be in good working order prior to the expected PIE start date. This building is equipped with the tools necessary for PIEs of this nature, but the long hiatus in coated particle fuel work has left it with aging analysis tools. This report identified several of these tools and rough estimates of what would be required to update and replace them. In addition, other ORNL buildings are available to support Building 3525 in specialized tasks along with the normal laboratory infrastructure. Before the AGR management embarks on any equipment development effort, the PIE tasks should be updated against current program (modeling and data) needs and better defined so that the items to be measured, their measurement uncertainties, and thru-put needs can be reviewed. A Data Task Matrix (DTM) should be prepared so that the program data needs can be compared against the identified PIE tasks and what is practical in the hot cell environment to make sure nothing is overlooked. Finally, thought should be given to the development of standardized equipment designs between sites to avoid redundant design efforts and different measurement techniques. This is a potentially cost saving effort that can also avoid data inconsistencies.

  6. Growth of Staphylococcus aureus MF 31 on the Top and Cut Surfaces of Southern Custard Pies

    PubMed Central

    Preonas, D. L.; Nelson, A. I.; Ordal, Z. John; Steinberg, M. P.; Wei, L. S.

    1969-01-01

    A Staphylococcus strain was inoculated on the top and cut surfaces of freshly baked Southern custard pies which were then packaged in a pasteboard carton and held at 30 C. Daily plate counts of surface sections 0.3 inch (0.76 cm) in thickness were made. The top surface inoculum showed a 24-hr lag time. This was due to the protective action of a top cakelike layer as shown by homogenization of the mix and coating of the surface. Substitution of all sweeteners with dextrose completely inhibited growth on the top surface. Further addition of dextrose to lower water activity (Aw) to 0.9 prevented growth on the cut surface as well, but such pies were organoleptically unacceptable. Growth on the top surface could also be prevented by 80 μg of undissociated sorbic acid per g in combination with 100 μg of undissociated propionic acid per g in the baked pie. Growth on the cakelike top surface was always retarded longer than on the cut surface provided the packaging allowed evaporation of surface moisture. Reducing the Aw of a different type of cream pie to 0.907 prevented top surface growth. It was concluded that baked cream pies with a cakelike top layer could be marketed with a “refrigerate after opening” label, provided the package maintains the moisture gradient caused by the surface skin and either a combination of 80 μg of undissociated sorbic acid per g and 100 μg undissociated propionic acid per g is present in the baked pie or the Aw of the baked pie is 0.920 or lower. Images PMID:5803631

  7. Application of large-scale computing infrastructure for diverse environmental research applications using GC3Pie

    NASA Astrophysics Data System (ADS)

    Maffioletti, Sergio; Dawes, Nicholas; Bavay, Mathias; Sarni, Sofiane; Lehning, Michael

    2013-04-01

    , execute location-based subroutines at each grid point and store the results back into the central repository for post-processing. An optional extension of this infrastructure will be to provide a 'ring buffer'-type database infrastructure, such that model results (e.g. test runs made to check parameter dependency or for development) can be visualised and downloaded after completion without submitting them to a permanent storage infrastructure. Data organization Data collected from sensors are archived and classified in distributed sites connected with an open-source software middleware, GSN. Publicly available data are available through common web services and via a cloud storage server (based on Swift). Collocation of the data and processing in the cloud would eventually eliminate data transfer requirements. Execution control logic Execution of the data analysis pipelines (for both the R-based analysis and the Alpine3D simulations) has been implemented using the GC3Pie framework developed by UZH. (https://code.google.com/p/gc3pie/). This allows large-scale, fault-tolerant execution of the pipelines to be described in terms of software appliances. GC3Pie also allows supervision of the execution of large campaigns of appliances as a single simulation. This poster will present the fundamental architectural components of the data analysis pipelines together with initial experimental results.

  8. Uranium hydrogeochemical survey of well waters from an area around Pie Town, Catron County, West-Central New Mexico, including concentrations of twenty-three additional elements

    SciTech Connect

    Morgan, T.L.; George, W.E.; Hensley, W.K.; Thomas, G.J.; Langhorst, A.L.

    1980-10-01

    As part of the Hydrogeochemical and Stream Sediment Reconnaissance (HSSR) of the National Uranium Resource Evaluation (NURE) sponsored by the US Department of Energy (DOE), the Los Alamos Scientific Laboratory (LASL) conducted a detailed hydrogeochemical survey of well waters in a 4250-km/sup 2/ area near Pie Town in west-central New Mexico. A total of 300 well samples was collected and analyzed for uranium and 23 other elements. The results of these analyses and carbonate and bicarbonate ion concentrations are presented in the Appendixes of this report. Uranium concentrations range from below the detection limit of 0.02 parts per billion (ppB) to 293.18 ppB and average 8.71 ppB. Samples containing high levels of uranium were collected from the Largo Creek valley west of Quemado, from a small area about 6 km east of Quemado, from a small area surrounding Pie Town, and from scattered locations in the area surrounding Adams Diggings north of Pie Town. Most of the samples containing high uranium concentrations were collected from wells associated with the volcanic sedimentary facies of the Datil formation. This formation is a likely source of mobile uranium that may be precipitating in the underlying Baca formation, a known uranium host unit. Bicarbonate ion concentration, while proportional to uranium concentration in some cases, is not a strong controlling factor in the uranium concentrations in samples from this area.

  9. Theoretical modeling of optical properties of Ag8 and Ag14 silver clusters embedded in an LTA sodalite zeolite cavity.

    PubMed

    Cuong, Ngo Tuan; Nguyen, Hue Minh Thi; Nguyen, Minh Tho

    2013-10-07

    Optical properties of silver Ag(n) nanoclusters are demonstrated to be dependent on their size, structure and charge state. It is found that when being contained in the sodalite cavity of LTA zeolite the tetradecanuclear hexacation silver cluster Ag14(6+) is stable. Its lower-lying states and optical spectrum are theoretically determined using the quantum chemical TD-DFT method. Its ground state possesses an outer-shell electron configuration of A1g(2)T2g(6) mimicking the s(2)p(6) valence of noble gas atoms. These frontier orbitals are constructed from 5s,5p(Ag)-AOs with contributions from framework oxygen atoms. Light absorption of Ag14(6+) embedded in the sodalite cage which is characterized by strong peaks centered at 331 and 476 nm (transitions 5s,p(Ag) → 5s,p(Ag)) leads to much longer wavelength emission. The sodalite cage, as a container, stabilizes the central Ag14(6+) cluster by electrostatic attraction. The absorption spectrum of the isovalent neutral Ag8 cluster embedded inside the same sodalite cavity is also simulated using TD-DFT and CASPT2 methods. This absorption spectrum which is similar to that of the Ag14(6+) cluster has two absorption bands in the near UV and visible regions.

  10. Personalized Integrated Educational System (PIES) for the Learner-Centered Information-Age Paradigm of Education: A Study to Improve the Design of the Functions and Features of PIES

    ERIC Educational Resources Information Center

    Dutta, Pratima

    2013-01-01

    The Personalized Integrated Educational System (PIES) design theory is a design recommendation regarding the function and features of Learning Managements Systems (LMS) that can support the information-age learner-centered paradigm of education. The purpose of this study was to improve the proposed functions and features of the PIES design theory…

  11. Principal angles separate subject illumination spaces in YDB and CMU-PIE.

    PubMed

    Beveridge, J Ross; Draper, Bruce A; Chang, Jen-Mei; Kirby, Michael; Kley, Holger; Peterson, Chris

    2009-02-01

    The theory of illumination subspaces is well developed and has been tested extensively on the Yale Face Database B (YDB) and CMU-PIE (PIE) data sets. This paper shows that if face recognition under varying illumination is cast as a problem of matching sets of images to sets of images, then the minimal principal angle between subspaces is sufficient to perfectly separate matching pairs of image sets from nonmatching pairs of image sets sampled from YDB and PIE. This is true even for subspaces estimated from as few as six images and when one of the subspaces is estimated from as few as three images if the second subspace is estimated from a larger set (10 or more). This suggests that variation under illumination may be thought of as useful discriminating information rather than unwanted noise.

  12. Progress on accelerated calculation of 3D MHD equilibrium with the PIES code

    NASA Astrophysics Data System (ADS)

    Raburn, Daniel; Reiman, Allan; Monticello, Donald

    2016-10-01

    Continuing progress has been made in accelerating the 3D MHD equilibrium code, PIES, using an external numerical wrapper. The PIES code (Princeton Iterative Equilibrium Solver) is capable of calculating 3D MHD equilibria with islands. The numerical wrapper has been demonstrated to greatly improve the rate of convergence in numerous cases corresponding to equilibria in the TFTR device where magnetic islands are present; the numerical wrapper makes use of a Jacobian-free Newton-Krylov solver along with adaptive preconditioning and a sophisticated subspace-restricted Levenberg backtracking algorithm. The wrapper has recently been improved by automation which combines the preexisting backtracking algorithm with insights gained from the stability of the Picard algorithm traditionally used with PIES. Improved progress logging and stopping criteria have also been incorporated in to the numerical wrapper.

  13. Contributions from Particles in Europe (PiE) 2010, Villefranche-sur-Mer, France: an introduction

    NASA Astrophysics Data System (ADS)

    Mikkelsen, Ole A.; Chami, Malik; Doxaran, David

    2012-04-01

    This special issue of Geo-Marine Letters presents selected contributions from the international conference Particles in Europe (PiE) 2010 organized by Sequoia Scientific, Inc., and the Laboratoire d'Océanographie de Villefranche (LOV) on 15-17 November 2010 in Villefranche-sur-Mer, France, and guest-edited by Ole Mikkelsen, Malik Chami and David Doxaran. PiE was initiated in 2008, in order to promote and further our understanding of the importance of suspended particulate matter (SPM) for a very wide range of processes in the aquatic environment—from optics and acoustics, over sediment transport, to the global carbon balance. The papers in this special issue are in particular concerned with the interaction between SPM and water optical properties, as well as how to use optical proxy measurements to understand SPM processes. The next PiE conference is scheduled for 17-19 October 2012 in Barcelona, Spain.

  14. Results of Parametric Design Studies of MOX Lead Test Assembly

    SciTech Connect

    Pavlovitchev, A.M.; Bychkov, S.A.; Lazarenko, A.A.; Sidorenko, V.D.; Styrin, Y.A.

    1998-12-01

    The parametric studies of MOX LTA design have been executed to choose plutonium content in assembly zones for two options of MOX LTA: 3-zones and Island. For 3-zones (100% Plutonium) MOX LTA the fissile plutonium content composition of 4.2%/3,0%/2% has been chosen. MOX LTA of the chosen compositions has been studied by using multi-assembly configuration that allows investigating of influence of MOX LTA environment: uranium assemblies of different irradiation. Plutonium Island with 54 plutonium pins in the center of MOX LTA has been considered in two modifications: uniform island; and graded island with lower plutonium content in one peripheral row of pins. It is shown that plutonium content in the uniform island cannot exceed 2.7% because of adopted power peaking limitations and therefore this design seems unreasonable for practical use. For graded island the plutonium content composition 3.8%/2.8% with uranium environment of 3.7% U-235 has been chosen. Evolution of assembly power and burnup distributions, inter-pin power and isotopic distributions while fuel irradiating have been analyzed. In addition to the base uranium environment of 3.7%, a set of calculations has been executed for 4.4%. Most of the studies have been executed by the code TVS-M that is at the final stage of licensing and it is to be used in the nearest future as a base instrument for VVER core calculations while using both uranium and MOX fuel. So the obtained results must be considered as preliminary ones and they demand additional analysis and investigations.

  15. The application of the Galerkin method to solving PIES for Laplace's equation

    NASA Astrophysics Data System (ADS)

    Bołtuć, Agnieszka; Zieniuk, Eugeniusz

    2016-06-01

    The paper presents the application of the Galerkin method to solving the parametric integral equation system (PIES) on the example of Laplace's equation. The main aim of the paper is the analysis of the effectiveness of two methods for PIES solving: the collocation method and the Galerkin method. Researches were performed on two examples with analytical solutions. Tests concern mainly the accuracy of obtained numerical solutions and their stability. For both analyzed methods calculations were made with the various number of expressions in the approximation series, whilst in the collocation method two variants of the arrangement of collocation points were considered. We also compared the complexity of both methods using the execution time.

  16. Placental immune editing switch (PIES): learning about immunomodulatory pathways from a unique case report.

    PubMed

    Bronchud, Miguel H; Tresserra, Francesc; Xu, Wenjie; Warren, Sarah; Cusido, Maite; Zantop, Bernat; Zenclussen, Ana Claudia; Cesano, Alessandra

    2016-12-13

    The hypothesis of this work is that, in order to escape the natural immune surveillance mechanisms, cancer cells and the surrounding microenvironment might express ectopically genes that are physiologically present in the placenta to mediate fetal immune-tolerance. These natural "placental immune-editing switch" mechanisms (PIES) may represent the result of millions of years of mammalian evolution developed to allow materno-fetal tolerance. Here, we introduce genes of the immune regulatory pathways that are either similarly over- or under-expressed in tumor vs normal tissue. Our analysis was carried out in primary breast cancer with metastatic homolateral axillary lymph nodes as well as placenta tissue (both uterine decidual tissue and term placenta tissue) from a pregnant woman. Gene expression profiling of paired non-self and self tissues (i.e. placenta/uterus; breast cancer/normal breast tissue; metastatic lymphnode/normal lymphnode tissue) was performed using the PanCancer Immune gene panel, a 770 Nanostring gene expression panel. Our findings reveal overlapping in specific immune gene expression in placenta and cancer tissue, suggesting that these genes might play an important role in maintaining immune tolerance both physiologically (in the placenta) and pathologically (in the cancer setting).

  17. In-Situ Detection of Micrometeoroids and Orbital Debris: The Pie Experiment On MIR.

    NASA Astrophysics Data System (ADS)

    Mandeville, J. C.; Maag, C. R.; Durin, C.

    During the last few years, investigation of impact features found on material retrieved after exposure to space for a long period of time, in low earth orbits, has provided us with a great deal of data on the particulate environment, either natural or man-made. The PIE detection device presented here has been deployed outside the Kvant-2 module attached to the Russian MIR station, between June 1996 and April 1997. Part of the experiment uses a detection technique similar to the one used in previous experiments flown on LDEF and MIR. Passive sensors are composed primarly of stacked thin metal foils (gold and aluminium). According to the size of the particles, they are either decelerated or fragmented upon high velocity impact. The size of holes or impact craters give information on the size or shape of the impacting particles. Samples have been retrieved for laboratory analysis. Comparison with data from LDEF, EuReCa, HST and previous experiments on MIR provides insight in the long term evolution of small particle population and in the debris environment of a permanently manned station. Some of the samples show evidence of secondary impact cratering: an attempt is made to locate the origin of the primary impact site. Some results about the possible origin of the impactors are provided by the chemical identification of particle remnants inside the craters

  18. Placental immune editing switch (PIES): learning about immunomodulatory pathways from a unique case report

    PubMed Central

    Bronchud, Miguel H.; Tresserra, Francesc; Xu, Wenjie; Warren, Sarah; Cusido, Maite; Zantop, Bernat; Zenclussen, Ana Claudia; Cesano, Alessandra

    2016-01-01

    The hypothesis of this work is that, in order to escape the natural immune surveillance mechanisms, cancer cells and the surrounding microenvironment might express ectopically genes that are physiologically present in the placenta to mediate fetal immune-tolerance. These natural “placental immune-editing switch” mechanisms (PIES) may represent the result of millions of years of mammalian evolution developed to allow materno-fetal tolerance. Here, we introduce genes of the immune regulatory pathways that are either similarly over- or under-expressed in tumor vs normal tissue. Our analysis was carried out in primary breast cancer with metastatic homolateral axillary lymph nodes as well as placenta tissue (both uterine decidual tissue and term placenta tissue) from a pregnant woman. Gene expression profiling of paired non-self and self tissues (i.e. placenta/uterus; breast cancer/normal breast tissue; metastatic lymphnode/normal lymphnode tissue) was performed using the PanCancer Immune gene panel, a 770 Nanostring gene expression panel. Our findings reveal overlapping in specific immune gene expression in placenta and cancer tissue, suggesting that these genes might play an important role in maintaining immune tolerance both physiologically (in the placenta) and pathologically (in the cancer setting). PMID:27852037

  19. Is the pie-crusting technique safe for MCL release in varus deformity correction in total knee arthroplasty?

    PubMed

    Meneghini, R Michael; Daluga, Andrew T; Sturgis, Lindsey A; Lieberman, Jay R

    2013-09-01

    Established for lateral release in TKA, the pie-crusting technique has not been studied for the medial collateral ligament (MCL). In cadaveric knees the MCL was release with a pie-crusting technique in one and traditional technique in the contralateral knee. Along with a control group, each MCL was subjected to mechanical testing. The stiffness, force and stress required to cause ligament elongation were less in the pie-crusting group (p < 0.05) compared to the control group, but were not statistically different than the traditional group. The pie-crusting group demonstrated a characteristic "stair-step" failure mode at the joint line, whereas the traditional group failed elastically at the tibial insertion. MCL pie-crusting is likely technique dependent since failure occurs within the ligament itself and further study is warranted.

  20. Giant Paperclip Necklaces, Soup-Can Rings and Cherry-Pie Hats

    ERIC Educational Resources Information Center

    Winters, Laurel A.

    2011-01-01

    In this article, the author describes an art project inspired by the wearable sculpture art created by artist Marjorie Schick. Students used wallpaper paste and newspapers to create papier-mache for a mountain hat, a cherry-pie mask/hat, a "dress" shoe and a Cubistic mask. Cardboard was used in many of these things, in addition to being used as…

  1. Slicing the Attitude Pie: A Validity and Reliability Study of a New Attitude Assessment Technique.

    ERIC Educational Resources Information Center

    Lull, James T.; Cappella, Joseph N.

    This paper introduces a new measure of attitude, the "attitude pie," which attempts to separate true neutrality from degree of indifference while providing an evaluation score on the issue being judged. A large reliability-validity study involving ten attitude traits, four different methods, and over one hundred subjects at three different times…

  2. EZDRAW. An Interactive Computer Graphics Program to Design Bar, Line, or Pie Graphs.

    DTIC Science & Technology

    1982-12-01

    Figure Page 1 EZDRAW System Configuration . . . . . . . . . )15 2 Representation of EZDRAW Levels by Menus . .16 * 3 GRAFMAKER Design...Graph . . . .. . . .. 47 8 EZDRAW Pie Graph ... 48 * 9 Main Module .. . . . . . .. B-2 10 Starting EZDR A’. . .. . . . .. B- 3 11 Initializing EZDRAW...Design Attributes . . . . A- 3 II EZDRAW Variables .......... ........ C-1 III EZDRAW Subroutines ..... .............. .D-1 IV DI-3000 Subroutines

  3. Preschool Instruction for the Exceptional (PIE) Project Report: 1976-1977.

    ERIC Educational Resources Information Center

    Ciccoricco, Edward A.; And Others

    Presented is the 1976-77 project report containing descriptions and evaluations of the five accomplished goals of the Preschool Instruction for the Exceptional (PIE) program which has provided services for 54 New Jersey students (3 to 5-years old). Described and discussed are the following objectives: (1) identification and diagnosis of preschool…

  4. Reflections on "Petit Battement sur le Cou de Pied": Is It Still Relevant?

    ERIC Educational Resources Information Center

    Paskevska, Anna

    2007-01-01

    This article presents multiple perspectives of "petit battement sur le cou de pied". These perspectives include historical, biomechanical, and pedagogic points of view. The article offers useful information for ballet specialists and applied research studies aimed at ballet pedagogy. (Contains 2 tables and 5 figures.)

  5. 49 CFR 40.375 - How does the initiating official start a PIE proceeding?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false How does the initiating official start a PIE proceeding? 40.375 Section 40.375 Transportation Office of the Secretary of Transportation PROCEDURES FOR TRANSPORTATION WORKPLACE DRUG AND ALCOHOL TESTING PROGRAMS Public Interest Exclusions § 40.375 How does the initiating official start a...

  6. Bars, Lines, & Pies: A Graphing Skills Program. Expect the Unexpected with Math[R

    ERIC Educational Resources Information Center

    Actuarial Foundation, 2013

    2013-01-01

    "Bars, Lines, & Pies" is a dynamic math program designed to build graphing skills in students, while also showing them the relevance of math in their lives. Developed by The Actuarial Foundation along with Scholastic, the graphing lessons and activities involve engaging, real-world examples about the environment and recycling. In these lessons,…

  7. Mnemonic Device for Relating the Eight Thermodynamic State Variables: The Energy Pie

    ERIC Educational Resources Information Center

    Fieberg, Jeffrey E.; Girard, Charles A.

    2011-01-01

    A mnemonic device, the energy pie, is presented that provides relationships between thermodynamic potentials ("U," "H," "G," and "A") and other sets of variables that carry energy units, "TS" and "PV." Methods are also presented in which the differential expressions for the potentials and the corresponding Maxwell relations follow from the energy…

  8. Oxidative stress in pied flycatcher (Ficedula hypoleuca) nestlings from metal contaminated environments in northern Sweden

    SciTech Connect

    Berglund, A.M.M. Sturve, J.; Foerlin, L.; Nyholm, N.E.I.

    2007-11-15

    Metals have been shown to induce oxidative stress in animals. One of the most metal polluted terrestrial environments in Sweden is the surroundings of a sulfide ore smelter plant located in the northern part of the country. Pied flycatcher nestlings (Ficedula hypoleuca) that grew up close to the industry had accumulated amounts of arsenic, cadmium, mercury, lead, iron and zinc in their liver tissue. The aim of this study was to investigate if pied flycatcher nestlings in the pollution gradient of the industry were affected by oxidative stress using antioxidant molecules and enzyme activities. The antioxidant assays were also evaluated in search for useful biomarkers in pied flycatchers. This study indicated that nestlings in metal contaminated areas showed signs of oxidative stress evidenced by up regulated hepatic antioxidant defense given as increased glutathione reductase (GR) and catalase (CAT) activities and slightly but not significantly elevated lipid peroxidation and glutathione-S-transferase (GST) activities. Stepwise linear regression indicated that lipid peroxidation and CAT activities were influenced mostly by iron, but iron and lead influenced the CAT activity to a higher degree. Positive relationships were found between GST and lead as well as GR activities and cadmium. We conclude that GR, CAT, GST activities and lipid peroxidation levels may function as useful biomarkers for oxidative stress in free-living pied flycatcher nestlings exposed to metal contaminated environments.

  9. Reading: Making It Personal Again--Now Serving PIE to Hungry Readers

    ERIC Educational Resources Information Center

    Hobbs, Nancy; Oleynik, Myra; Sacco, Kristen

    2009-01-01

    Something wonderful happens when children are asked to choose their own books and are given ample time to read and discuss them. They become hungry readers with an appetite for books! This simple strategy was the basis for developing the program known as PIE (Personalized Independent Enrichment) and its recipe for reading success. The goal of the…

  10. International Workshop on Characterization and PIE Needs for Fundamental Understanding of Fuels Performance and Safety

    SciTech Connect

    Not Listed

    2011-12-01

    The International Workshop on Characterization and PIE Needs to Support Science-Based Development of Innovative Fuels was held June 16-17, 2011, in Paris, France. The Organization for Economic Co-operation and Development (OECD), Nuclear Energy Agency (NEA) Working Party on the Fuel Cycle (WPFC) sponsored the workshop to identify gaps in global capabilities that need to be filled to meet projected needs in the 21st century. First and foremost, the workshop brought nine countries and associated international organizations, together in support of common needs for nuclear fuels and materials testing, characterization, PIE, and modeling capabilities. Finland, France, Germany, Republic of Korea, Russian Federation, Sweden, Switzerland, United Kingdom, United States of America, IAEA, and ITU (on behalf of European Union Joint Research Centers) discussed issues and opportunities for future technical advancements and collaborations. Second, the presentations provided a base level of understanding of current international capabilities. Three main categories were covered: (1) status of facilities and near term plans, (2) PIE needs from fuels engineering and material science perspectives, and (3) novel PIE techniques being developed to meet the needs. The International presentations provided valuable data consistent with the outcome of the National Workshop held in March 2011. Finally, the panel discussion on 21st century PIE capabilities, created a unified approach for future collaborations. In conclusion, (1) existing capabilities are not sufficient to meet the needs of a science-based approach, (2) safety issues and fuels behavior during abnormal conditions will receive more focus post-Fukushima; therefore we need to adopt our techniques to those issues, and (3) International collaboration is needed in the areas of codes and standards development for the new techniques.

  11. Combining MFD and PIE for accurate single-pair Förster resonance energy transfer measurements.

    PubMed

    Kudryavtsev, Volodymyr; Sikor, Martin; Kalinin, Stanislav; Mokranjac, Dejana; Seidel, Claus A M; Lamb, Don C

    2012-03-01

    Single-pair Förster resonance energy transfer (spFRET) experiments using single-molecule burst analysis on a confocal microscope are an ideal tool to measure inter- and intramolecular distances and dynamics on the nanoscale. Different techniques have been developed to maximize the amount of information available in spFRET burst analysis experiments. Multiparameter fluorescence detection (MFD) is used to monitor a variety of fluorescence parameters simultaneously and pulsed interleaved excitation (PIE) employs direct excitation of the acceptor to probe its presence and photoactivity. To calculate accurate FRET efficiencies from spFRET experiments with MFD or PIE, several calibration measurements are usually required. Herein, we demonstrate that by combining MFD with PIE information regarding all calibration factors as well as an accurate determination of spFRET histograms can be performed in a single measurement. In addition, the quality of overlap of the different detection volumes as well as the detection of acceptor photophysics can be investigated with MFD-PIE. Bursts containing acceptor photobleaching can be identified and excluded from further investigation while bursts that contain FRET dynamics are unaffected by this analysis. We have employed MFD-PIE to accurately analyze the effects of nucleotides and substrate on the interdomain separation in DnaK, the major bacterial heat shock protein 70 (Hsp70). The interdomain distance increases from 47 Å in the ATP-bound state to 84 Å in the ADP-bound state and slightly contracts to 77 Å when a substrate is bound. This is in contrast to what was observed for the mitochondrial member of the Hsp70s, Ssc1, supporting the notion of evolutionary specialization of Hsp70s for different cellular functions in different organisms and cell organelles.

  12. prepare_taxa_charts.py: A Python program to automate generation of publication ready taxonomic pie chart images from QIIME.

    PubMed

    Lakhujani, Vijay; Badapanda, Chandan

    2017-06-01

    QIIME (Quantitative Insights Into Microbial Ecology) is one of the most popular open-source bioinformatics suite for performing metagenome, 16S rRNA amplicon and Internal Transcribed Spacer (ITS) data analysis. Although, it is very comprehensive and powerful tool, it lacks a method to provide publication ready taxonomic pie charts. The script plot_taxa_summary.py bundled with QIIME generate a html file and a folder containing taxonomic pie chart and legend as separate images. The images have randomly generated alphanumeric names. Therefore, it is difficult to associate the pie chart with the legend and the corresponding sample identifier. Even if the option to have the legend within the html file is selected while executing plot_taxa_summary.py, it is very tedious to crop a complete image (having both the pie chart and the legend) due to unequal image sizes. It requires a lot of time to manually prepare the pie charts for multiple samples for publication purpose. Moreover, there are chances of error while identifying the pie chart and legend pair due to random alphanumeric names of the images. To bypass all these bottlenecks and make this process efficient, we have developed a python based program, prepare_taxa_charts.py, to automate the renaming, cropping and merging of taxonomic pie chart and corresponding legend image into a single, good quality publication ready image. This program not only augments the functionality of plot_taxa_summary.py but is also very fast in terms of CPU time and user friendly.

  13. Adsorption equilibrium and kinetics for SO2, NO, CO2 on zeolites FAU and LTA.

    PubMed

    Yi, Honghong; Deng, Hua; Tang, Xiaolong; Yu, Qiongfen; Zhou, Xuan; Liu, Haiyan

    2012-02-15

    In order to develop a single-step process for removing SO(2), NO, CO(2) in flue gas simultaneously by co-adsorption method. Pure component adsorption equilibrium and kinetics of SO(2), NO, and CO(2) on zeolite NaY, NaX, CaA were obtained respectively. Equilibrium data were analyzed by equilibrium model and Henry's law constant. The results suggest that Adsorption affinity follows the trend SO(2)>CO(2)>NO for the same adsorbent. Zeolite with stronger polar surface is a more promising adsorbent candidate. Kinetics behavior was investigated using the breakthrough curve method. The overall mass transfer coefficient and diffusivity factor were determined by a linear driving force model. The results are indicative of micropore diffusion controlling mechanism. NaY zeolite has the minimum resistance of mass transfer duo to the wide pore distribution and large pore amount. CaA zeolite exhibits the highest spatial hindered effect. Finally, co-adsorption effect of SO(2), NO, and CO(2) were investigated by multi-components breakthrough method. SO(2) and NO may form new adsorbed species, however, CO(2) presents a fast breakthrough. Chemical adsorption causes SO(2) transforms to SO(4)(2-), however, element N and C are not detected in adsorbed zeolites.

  14. The effects of selected modern technological concepts on the performance and handling characteristics of LTA vehicles

    NASA Technical Reports Server (NTRS)

    Mazza, C. J.

    1975-01-01

    The results of an airship design sensitivity study are presented. A wide variety of airship design concepts, including the classical and high aero-lift augmented-hybrids are examined with regard to specific technological improvements, and consequent gains in performance, stability and control and flying qualities. Variations in size, payload, power required and airspeed are quantitatively analyzed for airships representing aero-to-buoyant lift ratios of zero to 3.0 over a range of technology improvements implying reduced drag, reduced structural weight fractions and lighter, more efficient propulsion systems. Qualitatively, future airships are discussed in terms of stability, control and flying qualities requirements dictated by projected demands for vastly improved operational effectiveness and ease of handling. Such topics include stability augmentation systems, load-alleviation systems and total computer state-sensing and controls management systems. It was shown that, for the most part, highly refined conventional designs offer attractive gains in both performance and ease of handling. Hybrid airships represent a good potential for missions requiring the transport of heavy payloads at higher airspeeds over shorter ranges without the capability for sustained hover and vertical flight.

  15. Testicular distribution and toxicity of a novel LTA4H inhibitor in rats

    SciTech Connect

    Ward, P.D. La, D.

    2014-07-01

    JNJ 40929837, a novel leukotriene A4 hydrolase inhibitor in drug development, was reported to induce testicular toxicity in rats. The mechanism of toxicity was considered to be rodent specific and not relevant to humans. To further investigate this finding in rats, the distribution and toxicokinetics of JNJ 40929837 and its two metabolites, M1 and M2, were investigated. A quantitative whole body autoradiography study showed preferential distribution and retention of JNJ 40929837-derived radioactivity in the testes consistent with the observed site of toxicity. Subsequent studies with unlabeled JNJ 40929837 showed different metabolite profiles between the plasma and testes. Following a single oral 50 mg/kg dose of JNJ 40929837, M2 was the primary metabolite in plasma whereas M1 was the primary metabolite in testes. The exposure of M1 was 386-fold higher in the testes compared to plasma whereas M2 had limited exposure in testes. Furthermore, the T{sub max} of M1 was 48 h in testes suggesting a large accumulation potential of this metabolite in testes compared to plasma. Following six months of repeated daily oral dosing, M1 accumulated approximately five-fold in the testes whereas the parent did not accumulate. These results indicate that the toxicokinetic profiles of JNJ 40929837 and its two metabolites in testes are markedly different compared to plasma and support the importance of understanding the toxicokinetic profiles of compounds and their metabolites in organs/tissues where toxicity is observed. - Highlights: • JNJ 40929837-derived radioactivity preferentially distributed into testes • Primary metabolite flip-flop in plasma and testes • The primary metabolite in testes accumulated 5-fold but not parent.

  16. A new classification of the Pied Woodpeckers assemblage (Dendropicini, Picidae) based on a comprehensive multi-locus phylogeny.

    PubMed

    Fuchs, Jérôme; Pons, Jean-Marc

    2015-07-01

    The pied woodpecker assemblage historically included the widespread genera Picoides and Dendrocopos. The assignment of species to either of these two genera has for long puzzled systematists due to their overall plumage similarity. Recent molecular studies not only suggested that both of these genera are not monophyletic, but also that four other genera, the African Dendropicos the South American Veniliornis and two Asian monospecific genera (Hypopicus and Sapheopipo) are nested within the Dendrocopos-Picoides clade. Yet, our current understanding of the phylogeny and taxonomy of this group is still very partial because several distinctive Old World species that have been assigned to different genera throughout their taxonomic history have not been sampled yet. Here, using DNA sequence data gathered from four loci, we reconstructed a species level phylogeny of the Indo-Malayan and Palearctic Pied Woodpeckers to understand the phylogenetic relationships and biogeographic history of the Eurasian species with respect to African and New World lineages. Our phylogenetic analyses revealed nine strongly supported clades within the Dendropicini. Noticeably, two species that had disputed affinities at the genus level clustered in clades with species from the same biogeographical region: the Brown-backed Woodpecker (D. obsoletus) is nested in Dendropicos and the Arabian Woodpecker (D. dorae) is related to two Eurasian species, the Brown-fronted (D. auriceps) and Middle-spotted woodpeckers (D. medius). The nine clades have a strong biogeographic component and very few dispersal event among bioregions occurred. For example, the African species formed a clade, suggesting that only one dispersal event is needed to explain the presence of Dendropicini in Africa. Based on our phylogenetic results, we propose a new classification of the Dendropicini that recognizes nine genera.

  17. Demographic Divergence History of Pied Flycatcher and Collared Flycatcher Inferred from Whole-Genome Re-sequencing Data

    PubMed Central

    Nadachowska-Brzyska, Krystyna; Burri, Reto; Olason, Pall I.; Kawakami, Takeshi; Smeds, Linnéa; Ellegren, Hans

    2013-01-01

    Profound knowledge of demographic history is a prerequisite for the understanding and inference of processes involved in the evolution of population differentiation and speciation. Together with new coalescent-based methods, the recent availability of genome-wide data enables investigation of differentiation and divergence processes at unprecedented depth. We combined two powerful approaches, full Approximate Bayesian Computation analysis (ABC) and pairwise sequentially Markovian coalescent modeling (PSMC), to reconstruct the demographic history of the split between two avian speciation model species, the pied flycatcher and collared flycatcher. Using whole-genome re-sequencing data from 20 individuals, we investigated 15 demographic models including different levels and patterns of gene flow, and changes in effective population size over time. ABC provided high support for recent (mode 0.3 my, range <0.7 my) species divergence, declines in effective population size of both species since their initial divergence, and unidirectional recent gene flow from pied flycatcher into collared flycatcher. The estimated divergence time and population size changes, supported by PSMC results, suggest that the ancestral species persisted through one of the glacial periods of middle Pleistocene and then split into two large populations that first increased in size before going through severe bottlenecks and expanding into their current ranges. Secondary contact appears to have been established after the last glacial maximum. The severity of the bottlenecks at the last glacial maximum is indicated by the discrepancy between current effective population sizes (20,000–80,000) and census sizes (5–50 million birds) of the two species. The recent divergence time challenges the supposition that avian speciation is a relatively slow process with extended times for intrinsic postzygotic reproductive barriers to evolve. Our study emphasizes the importance of using genome-wide data to

  18. Synthesis and characterization of LTA nanozeolite using barley husk silica: Mercury removal from standard and real solutions

    SciTech Connect

    Azizi, Seyed Naser; Dehnavi, Ahmad Roozbehani; Joorabdoozha, Amir

    2013-05-15

    Highlights: ► Silica extraction from barley husk with high purity for the synthesis of A nanozeolite. ► Free template A nanozeolite synthesized via new source of silica at low temperature. ► Optimization of SiO{sub 2}/Al{sub 2}O{sub 3}, Na{sub 2}O/SiO{sub 2} ratios, temperature and time of the synthesis. ► Utilizing of synthesized A nanozeolite for mercury removal from aqueous solutions. ► Mercury removal at optimized pH, contact time and adsorbent dose from real solution. - Abstract: In this study, synthesized Lined Type A (LTA) nanozeolite from barley husk silica (BHS) was used for mercury removal from standard and real aqueous solutions. The BHS in amorphous phase with 80% purity was extracted from barley husk ash (BHA), and used effectively as a new source of silica for the synthesis of NaA nanozeolite. The NaA nanocrystal in pure phase has been synthesized at low temperature, without adding any organic additives. The effects of heating time, reaction temperature, SiO{sub 2}/Al{sub 2}O{sub 3}, and Na{sub 2}O/SiO{sub 2} mole ratios on the crystallization of NaA nanozeolite were studied. The adsorption capacity of mercury (II) was studied as a function of pH, contact time, and amount of adsorbent. The crystallization of NaA nanozeolite from BHS was characterized by X-ray diffraction (XRD), X-ray fluorescence (XRF), scanning electron microscopy (SEM), energy-dispersive X-ray (EDX), Brunauer–Emmett–Teller (BET), and FTIR techniques. Moreover, concentration of Hg{sup 2+} ions in the aqueous solutions was analyzed by hydride generation atomic absorption spectroscopy method (HG-AAS). The standard and real samples analysis showed that NaA nanozeolite is capable of Hg{sup 2+} ions removal from the aqueous solutions. Efficiency of mercury (II) adsorption from real solutions onto the nano-sized NaA zeolite was 98%.

  19. Comparison between urinary 11-dehydrothromboxane B2 detection and platelet Light Transmission Aggregometry (LTA) assays for evaluating aspirin response in elderly patients with coronary artery disease.

    PubMed

    Liu, Tengfei; Zhang, Jingwei; Chen, Xiahuan; Feng, Xueru; Fu, Sidney W; McCaffrey, Timothy A; Liu, Meilin

    2015-10-15

    Aspirin is widely used in the primary and secondary prevention of cardiovascular diseases. The aim of our study was to compare between two established methods of aspirin response, urinary 11-dehydrothromboxane B2 (11dhTXB2) and platelet Light Transmission Aggregometry (LTA) assays in elderly Chinese patients with coronary artery disease (CAD), and to investigate the clinical significance of both methods in predicting cardiovascular events. Urinary 11dhTxB2 assay and arachidonic acid-induced (AA, 0.5mg/ml) platelet aggregation by Light Transmission Aggregometry (LTAAA) assay were measured to evaluate aspirin responses. High-on aspirin platelet reactivity (HAPR) was defined as urinary 11dhTxB2>1500pg/mg or AA-induced platelet aggregation≥15.22%-the upper quartile of our enrolled population. The two tests showed a poor correlation for aspirin inhibition (r=0.063) and a poor agreement in classifying HAPR (kappa=0.053). With a mean follow-up time of 12months, cardiovascular events occurred more frequently in HAPR patients who were diagnosed by LTA assay as compared with no-HAPR patients (22.5% versus 10.6%, P=0.039, OR=2.45, 95% CI=1.06-5.63). However, the HAPR status, as determined by urinary 11dTXB2 measurement, did not show a significant correlation with outcomes.

  20. Precision Information Environment (PIE) for International Safeguards: Pre-Demonstration Development Use Cases

    SciTech Connect

    Gastelum, Zoe N.; Henry, Michael J.

    2013-11-13

    In FY2013, the PIE International Safeguards team demonstrated our development progress to U.S. Department of Energy (DOE) staff from the Office of Nonproliferation and International Security (NA-24, our client) and the Office of Defense Nuclear Nonproliferation Research and Development (NA-22). Following the demonstration, the team was asked by our client to complete additional development prior to a planned demonstration at the International Atomic Energy Agency (IAEA), scheduled tentatively for January or spring of 2014. The team discussed four potential areas for development (in priority order), and will develop them as time and funding permit prior to an IAEA demonstration. The four capability areas are: 1. Addition of equipment manuals to PIE-accessible files 2. Optical character recognition (OCR) of photographed text 3. Barcode reader with information look-up from a database 4. Add Facilities to Data Model 5. Geospatial capabilities with information integration Each area will be described below in a use case.

  1. Arthroscopic trans-portal deep medial collateral ligament pie-crusting release.

    PubMed

    Atoun, Ehud; Debbi, Ronen; Lubovsky, Omri; Weiler, Andreas; Debbi, Eytan; Rath, Ehud

    2013-02-01

    Arthroscopic treatments of meniscal injuries of the knee are among the most common orthopaedic procedures performed. Adequate visualization of the posterior horn of the medial meniscus might be challenging, especially in patients with tight medial compartments. In these cases instrument manipulation in an attempt to reach the posterior horn of the meniscus can cause an iatrogenic chondral injury because of the narrow medial joint space. A transcutaneous medial collateral ligament (MCL) pie-crusting release facilitates expansion of the medial joint space in a case of a tight medial compartment. Nevertheless, it might cause injury to the superficial MCL, infection, and pain and injury to the saphenous nerve because of multiple needle punctures of the skin. We describe an inside-out, arthroscopic deep MCL pie-crusting release, which allows access to the medial meniscus through the anterior approach to provide good visualization of the footprint and sufficient working space.

  2. Tunable PIE and synchronized gating detections by FastFLIM for quantitative microscopy measurements of fast dynamics of single molecules

    NASA Astrophysics Data System (ADS)

    Sun, Yuansheng; Coskun, Ulas; Ferreon, Allan Chris; Barbieri, Beniamino; Liao, Shih-Chu Jeff

    2016-03-01

    The crosstalk between two fluorescent species causes problems in fluorescence microscopy imaging, especially for quantitative measurements such as co-localization, Förster resonance energy transfer (FRET), fluorescence cross correlation spectroscopy (FCCS). In laser scanning confocal microscopy, the lasers can be switched on and off by acousto-optic tunable filters (AOTF) in the microsecond scale for alternative line scanning in order to avoid the crosstalk while minimizing the time delay between two lasers on the same pixel location. In contrast, the pulsed interleaved excitation (PIE) technique synchronizes two pulsed lasers of different wavelengths in the nanosecond scale to enable measuring superfast dynamics of two fluorescent species simultaneously and yet quantitatively without the crosstalk contamination. This feature is critical for many cell biology applications, e.g. accurate determination of stoichiometry in FRET measurements for studying protein-protein interactions or cell signal events, detection of weaker bindings in FCCS by eliminating the false cross correlation due to the crosstalk. The PIE has been used with the time correlated single photon counting (TCSPC) electronics. Here, we describe a novel PIE development using the digital frequency domain (DFD) technique -- FastFLIM, which provides tunable PIE setups and synchronized gating detections, tailored and optimized to specific applications. A few PIE setups by FastFLIM and measurement examples are described. Combined with the sensitivity of Alba and Q2 systems, the PIE allowed us to quantitatively measure the fast dynamics of single molecules.

  3. [Genetic mechanisms of resistance and susceptibility to leukemia in Ayrshire and black pied cattle breeds determined by allelic distribution of gene Bola-DRB3].

    PubMed

    Udina, I G; Karamysheva, E E; Turkova, S O; Orlova, A R; Sulimova, G E

    2003-03-01

    In the herds of Ayrshire and Black Pied cattle breeds of Russian selection, comparative analysis of allelic distribution of BoLA-DRB3 was performed in animal groups with different status of persistent lymphocytosis (PL) caused by the bovine leukemia virus (BLV). Alleles were typed by PCR-RFLP. Different spectra of BoLA-DRB3 alleles mediating susceptibility and resistance to leukemia were detected in the studied breeds. The role of amino acid motives in beta 1 domain of BoLA-DRB3 antigens was confirmed: ER (in positions 70-71), in resistance to leukemia and VDTY and VDTV (75-78), in susceptibility to leukemia. The nucleotide sequence of allele BoLA-DRB3.2*7 with deletion of codon 65, which resulted in the changed conformation of the corresponding antigen molecule, was associated with resistance to PL. Cows of Black Pied and Ayrshire breeds with genotypes coding VDTY/VDTV (RR = 11.67, P = 0.014) and VDTY/VDTY (RR = 4.71, P = 0.022), respectively, were shown to be susceptible to PL. The role of heterozygosity level was demonstrated (estimated by BoLA-DRB3 alleles and by amino acid motives in positions 75-78 of the antigen) as an unspecific factor of resistance to PL. The lowest heterozygosity level by amino acid motives (75-78) was revealed in PL animals, for which sample inbreeding coefficients were detected: F = 0.324 and F = 0.084 in Ayrshire and Black Pied breeds, respectively.

  4. Parallelization of LSODE in PIES Using NVIDIA's CUDA Architecture for GPGPU

    NASA Astrophysics Data System (ADS)

    Thompson, Paul; Ethier, Stephane

    2009-11-01

    The Princeton Iterative Equilibrium Solver (PIES) is a powerful tool for computing three dimensional MHD equilibria, without making assumptions about the form of the magnetic field. Part of its strength comes from its ability to handle equilibria with islands and stochastic regions. However, a high-resolution PIES calculation often takes several hours to complete, spending most of its time in the Livermore Solver for Ordinary Differential Equations (LSODE) to follow field-line trajectories. This work examines the feasibility of speeding up these calculations by taking advantage of the parallel computing resources of programmable Graphic Processor Units (GPUs). To this end, the LSODA variant version of LSODE is converted to NVIDIA's C for CUDA application programming interface and tested against its original Fortran version on an NVIDIA Tesla Cluster. Run times are compared between the serial and parallel versions, with special attention given to different scaling options. The new code is also analyzed for bottlenecks and opportunities for additional speedups, with the ultimate goal of developing a PIES-based MHD solver capable of running between experimental shots.

  5. "Operation Pied Piper": a psychoanalytic narrative of authority in a time of war.

    PubMed

    Farley, Lisa

    2012-01-01

    The evacuation of British children during World War II is read alongside the legend of the "Pied Piper" after which the mass migration was officially named. While virtually every British account of World War II makes mention of the evacuation, most are silent on the question of its ominous title: "Operation Pied Piper." This paper traces the legend's key theme - on influencing and being influenced - as it surfaces in the writing of one child analyst and one social worker charged with the responsibility of leading a family of five hostels for British youth. At a time when Hitler's deadly regime reached unprecedented heights across the Channel, the legend of the "Pied Piper" becomes a highly suggestive metaphor for thinking about D. W. Winnicott and Clare Britton's writing on what authority could mean in the face of leadership gone terribly wrong. Quite another, profoundly intimate loss of leadership haunts their words as well: Sigmund Freud, in exile from Hitler's Europe and leader of the psychoanalytic movement, died in London just weeks after the first wave of Blitz evacuations. It is in this context that Winnicott and Britton articulated a theory of authority that could address the losses of history without at the same time demanding the loss of the mind.

  6. African departure rather than migration speed determines variation in spring arrival in pied flycatchers.

    PubMed

    Ouwehand, Janne; Both, Christiaan

    2017-01-01

    Properly timed spring migration enhances reproduction and survival. Climate change requires organisms to respond to changes such as advanced spring phenology. Pied flycatchers Ficedula hypoleuca have become a model species to study such phenological adaptations of long-distance migratory songbirds to climate change, but data on individuals' time schedules outside the breeding season are still lacking. Using light-level geolocators, we studied variation in migration schedules across the year in a pied flycatcher population in the Netherlands, which sheds light on the ability for individual adjustments in spring arrival timing to track environmental changes at their breeding grounds. We show that variation in arrival dates to breeding sites in 2014 was caused by variation in departure date from sub-Saharan Africa and not by environmental conditions encountered en route. Spring migration duration was short for all individuals, on average 2 weeks. Males migrated ahead of females in spring, while migration schedules in autumn were flexibly adjusted according to breeding duties. Individuals were therefore not consistently early or late throughout the year. In fast migrants like our Dutch pied flycatchers, advancement of arrival to climate change likely requires changes in spring departure dates. Adaptation for earlier arrival may be slowed down by harsh circumstances in winter, or years with high costs associated with early migration.

  7. PIE on Safety-Tested AGR-1 Compact 5-1-1

    SciTech Connect

    Hunn, John D.; Morris, Robert Noel; Baldwin, Charles A.; Montgomery, Fred C.; Gerczak, Tyler J.

    2015-08-01

    Post-irradiation examination (PIE) is being performed in support of tristructural isotropic (TRISO) coated particle fuel development and qualification for High-Temperature Gas-cooled Reactors (HTGRs). AGR-1 was the first in a series of TRISO fuel irradiation experiments initiated in 2006 under the Advanced Gas Reactor (AGR) Fuel Development and Qualification Program; this work continues to be funded by the Department of Energy's Office of Nuclear Energy as part of the Advanced Reactor Technologies (ART) initiative. AGR-1 fuel compacts were fabricated at Oak Ridge National Laboratory (ORNL) in 2006 and irradiated for three years in the Idaho National Laboratory (INL) Advanced Test Reactor (ATR) to demonstrate and evaluate fuel performance under HTGR irradiation conditions. PIE is being performed at INL and ORNL to study how the fuel behaved during irradiation, and to examine fuel performance during exposure to elevated temperatures at or above temperatures that could occur during a depressurized conduction cooldown event. This report summarizes safety testing of irradiated AGR-1 Compact 5-1-1 in the ORNL Core Conduction Cooldown Test Facility (CCCTF) and post-safety testing PIE.

  8. Vortex wake, downwash distribution, aerodynamic performance and wingbeat kinematics in slow-flying pied flycatchers

    PubMed Central

    Muijres, Florian T.; Bowlin, Melissa S.; Johansson, L. Christoffer; Hedenström, Anders

    2012-01-01

    Many small passerines regularly fly slowly when catching prey, flying in cluttered environments or landing on a perch or nest. While flying slowly, passerines generate most of the flight forces during the downstroke, and have a ‘feathered upstroke’ during which they make their wing inactive by retracting it close to the body and by spreading the primary wing feathers. How this flight mode relates aerodynamically to the cruising flight and so-called ‘normal hovering’ as used in hummingbirds is not yet known. Here, we present time-resolved fluid dynamics data in combination with wingbeat kinematics data for three pied flycatchers flying across a range of speeds from near hovering to their calculated minimum power speed. Flycatchers are adapted to low speed flight, which they habitually use when catching insects on the wing. From the wake dynamics data, we constructed average wingbeat wakes and determined the time-resolved flight forces, the time-resolved downwash distributions and the resulting lift-to-drag ratios, span efficiencies and flap efficiencies. During the downstroke, slow-flying flycatchers generate a single-vortex loop wake, which is much more similar to that generated by birds at cruising flight speeds than it is to the double loop vortex wake in hovering hummingbirds. This wake structure results in a relatively high downwash behind the body, which can be explained by the relatively active tail in flycatchers. As a result of this, slow-flying flycatchers have a span efficiency which is similar to that of the birds in cruising flight and which can be assumed to be higher than in hovering hummingbirds. During the upstroke, the wings of slowly flying flycatchers generated no significant forces, but the body–tail configuration added 23 per cent to weight support. This is strikingly similar to the 25 per cent weight support generated by the wing upstroke in hovering hummingbirds. Thus, for slow-flying passerines, the upstroke cannot be regarded as

  9. Vortex wake, downwash distribution, aerodynamic performance and wingbeat kinematics in slow-flying pied flycatchers.

    PubMed

    Muijres, Florian T; Bowlin, Melissa S; Johansson, L Christoffer; Hedenström, Anders

    2012-02-07

    Many small passerines regularly fly slowly when catching prey, flying in cluttered environments or landing on a perch or nest. While flying slowly, passerines generate most of the flight forces during the downstroke, and have a 'feathered upstroke' during which they make their wing inactive by retracting it close to the body and by spreading the primary wing feathers. How this flight mode relates aerodynamically to the cruising flight and so-called 'normal hovering' as used in hummingbirds is not yet known. Here, we present time-resolved fluid dynamics data in combination with wingbeat kinematics data for three pied flycatchers flying across a range of speeds from near hovering to their calculated minimum power speed. Flycatchers are adapted to low speed flight, which they habitually use when catching insects on the wing. From the wake dynamics data, we constructed average wingbeat wakes and determined the time-resolved flight forces, the time-resolved downwash distributions and the resulting lift-to-drag ratios, span efficiencies and flap efficiencies. During the downstroke, slow-flying flycatchers generate a single-vortex loop wake, which is much more similar to that generated by birds at cruising flight speeds than it is to the double loop vortex wake in hovering hummingbirds. This wake structure results in a relatively high downwash behind the body, which can be explained by the relatively active tail in flycatchers. As a result of this, slow-flying flycatchers have a span efficiency which is similar to that of the birds in cruising flight and which can be assumed to be higher than in hovering hummingbirds. During the upstroke, the wings of slowly flying flycatchers generated no significant forces, but the body-tail configuration added 23 per cent to weight support. This is strikingly similar to the 25 per cent weight support generated by the wing upstroke in hovering hummingbirds. Thus, for slow-flying passerines, the upstroke cannot be regarded as inactive

  10. Effects of inbreeding on fighting ability measured in Aosta Chestnut and Aosta Black Pied cattle.

    PubMed

    Sartori, C; Mantovani, R

    2012-09-01

    Aosta Black Pied (ABP) and Aosta Chestnut (AC) are dual-purpose cattle indigenous to the western Alps and famous for their fighting ability in traditional Italian Batailles de Reines. The present study aimed to investigate the influence of inbreeding on breeding values for fighting ability achieved in participants. Inbreeding (F) and average relatedness (AR) were obtained from the entire pedigree information available (19,554 and 87,967 records for ABP and AC, respectively). Data (n = 23,998) relating to 8,259 cows competing in years 2001-2009 were analyzed to obtain heritability (h(2)) estimates and breeding values for the trait. A placement score was chosen as a phenotype for fighting ability and both a classical quantitative model (NORM) and its implementation, used to identify its indirect genetic effects (COMP), were analyzed using the expectation maximization-REML (EM-REML) method. The F and AR trends in animals born between 1990 and 2009 were generally low and were greater for ABP (+0.06%/yr) than for AC (+0.03%/yr) populations, which also presented a greater mean F (about 2.8% ± 1.7% vs. 0.8% ± 1.5% for ABP and AC, respectively) and mean AR among individuals (about 1.0% ± 0.8% vs. 0.4% ± 0.3% for ABP and AC, respectively). Heritability estimates from 0.083 ± 0.036 to 0.120 ± 0.037 were obtained using the NORM model, accounting for or not accounting for F, respectively. Similar results were obtained also for the COMP model, with h(2) estimates of 0.12 ± 0.037, whether or not F was taken into consideration. Linear regression analyses carried out on the 33 major lineages to which most of participants belonged (n = 6,087) revealed an overall negative trend of EBV compared with the increase of either F (b = -21.3, P < 0.01) or AR (b = -50.1, P < 0.01). However, a great variability in the relationship between EBV and F or AR was found by analyzing data within lineages. Despite the variability, an unfavorable effect of inbreeding was detected in the

  11. Detection of rhodopsin dimerization in situ by PIE-FCCS, a time-resolved fluorescence spectroscopy.

    PubMed

    Smith, Adam W

    2015-01-01

    Rhodopsin self-associates in the plasma membrane. At low concentrations, the interactions are consistent with a monomer-dimer equilibrium (Comar et al., J Am Chem Soc 136(23):8342-8349, 2014). At high concentrations in native tissue, higher-order clusters have been observed (Fotiadis et al., Nature 421:127-128, 2003). The physiological role of rhodopsin dimerization is still being investigated, but it is clear that a quantitative assessment is essential to determining the function of rhodopsin clusters in vision. To quantify rhodopsin interactions, I will outline the theory and methodology of a specialized time-resolved fluorescence spectroscopy for measuring membrane protein-protein interactions called pulsed-interleaved excitation fluorescence cross-correlation spectroscopy (PIE-FCCS). The strength of this technique is its ability to quantify rhodopsin interactions in situ (i.e., a live cell plasma membrane). There are two reasons for restricting the scope to live cell membranes. First, the compositional heterogeneity of the plasma membrane creates a complex milieu with thousands of lipid, protein, and carbohydrate species. This makes it difficult to infer quaternary interactions from detergent solubilized samples or construct a model phospholipid bilayer that recapitulates all of the interactions present in native membranes. Second, organizational structure and dynamics is a key feature of the plasma membrane, and fixation techniques like formaldehyde cross-linking and vitrification will modulate the interactions. PIE-FCCS is based on two-color fluorescence imaging with time-correlated single-photon counting (TCSPC) (Becker et al., Rev Sci Instrum 70:1835-1841, 1999). By time-tagging every detected photon, the data can be analyzed as a fluorescence intensity distribution, fluorescence lifetime histogram, or fluorescence (cross-)correlation spectra (FCS/FCCS) (Becker, Advanced time-correlated single-photon counting techniques, Springer, Berlin, 2005). These

  12. Results.

    ERIC Educational Resources Information Center

    Zemsky, Robert; Shaman, Susan; Shapiro, Daniel B.

    2001-01-01

    Describes the Collegiate Results Instrument (CRI), which measures a range of collegiate outcomes for alumni 6 years after graduation. The CRI was designed to target alumni from institutions across market segments and assess their values, abilities, work skills, occupations, and pursuit of lifelong learning. (EV)

  13. Calling Where It Counts: Subordinate Pied Babblers Target the Audience of Their Vocal Advertisements

    PubMed Central

    Humphries, David J.; Finch, Fiona M.; Bell, Matthew B. V.; Ridley, Amanda R.

    2015-01-01

    For territorial group-living species, opportunities to reproduce on the natal territory can be limited by a number of factors including the availability of resources within a territory, access to unrelated individuals, and monopolies on reproduction by dominant group members. Individuals looking to reproduce are therefore faced with the options of either waiting for a breeding opportunity to arise in the natal territory, or searching for reproductive opportunities in non-natal groups. In the cooperatively breeding Southern pied babbler, Turdoides bicolor, most individuals who achieve reproductive success do so through taking up dominant breeding positions within non-natal groups. For subordinate pied babblers therefore, searching for breeding opportunities in non-natal groups is of primary importance as this represents the major route to reproductive success. However, prospecting (where individuals leave the group to search for reproductive opportunities within other groups) is costly and individuals rapidly lose weight when not part of a group. Here we demonstrate that subordinate pied babblers adopt an alternative strategy for mate attraction by vocal advertisement from within their natal territories. We show that subordinates focus their calling efforts on the edges of their territory, and specifically near boundaries with neighbouring groups that have potential breeding partners (unrelated individuals of the opposite sex). In contrast to prospecting, calling individuals showed no body mass loss associated with this behaviour, suggesting that calling from within the group may provide a ‘cheap’ advertisement strategy. Additionally, we show that subordinates use information regarding the composition of neighbouring groups to target the greatest number of potential mating partners. PMID:26177094

  14. Calling Where It Counts: Subordinate Pied Babblers Target the Audience of Their Vocal Advertisements.

    PubMed

    Humphries, David J; Finch, Fiona M; Bell, Matthew B V; Ridley, Amanda R

    2015-01-01

    For territorial group-living species, opportunities to reproduce on the natal territory can be limited by a number of factors including the availability of resources within a territory, access to unrelated individuals, and monopolies on reproduction by dominant group members. Individuals looking to reproduce are therefore faced with the options of either waiting for a breeding opportunity to arise in the natal territory, or searching for reproductive opportunities in non-natal groups. In the cooperatively breeding Southern pied babbler, Turdoides bicolor, most individuals who achieve reproductive success do so through taking up dominant breeding positions within non-natal groups. For subordinate pied babblers therefore, searching for breeding opportunities in non-natal groups is of primary importance as this represents the major route to reproductive success. However, prospecting (where individuals leave the group to search for reproductive opportunities within other groups) is costly and individuals rapidly lose weight when not part of a group. Here we demonstrate that subordinate pied babblers adopt an alternative strategy for mate attraction by vocal advertisement from within their natal territories. We show that subordinates focus their calling efforts on the edges of their territory, and specifically near boundaries with neighbouring groups that have potential breeding partners (unrelated individuals of the opposite sex). In contrast to prospecting, calling individuals showed no body mass loss associated with this behaviour, suggesting that calling from within the group may provide a 'cheap' advertisement strategy. Additionally, we show that subordinates use information regarding the composition of neighbouring groups to target the greatest number of potential mating partners.

  15. Pharmaceuticals and the Environment (PiE): Evolution and impact of the published literature revealed by bibliometric analysis.

    PubMed

    Daughton, Christian G

    2016-08-15

    The evolution and impact of the published literature surrounding the transdisciplinary, multifaceted topic of pharmaceuticals as contaminants in the environment is examined for the first time in an historical context. The preponderance of literature cited in this examination represents the earlier works. As an historical chronology, the focus is on the emergence of key, specific aspects of the overall topic (often termed PiE) in the published literature and on the most highly cited works. This examination is not a conventional, technical review of the literature; as such, little attention was devoted to the more recent literature. The many dimensions involved with PiE span over 70years of published literature. Some articles began to appear in published works in the 1940s and earlier, while others only began to receive attention in the 1990s and later. Decades of early research on what at the time seemed to be disconnected topics eventually coalesced in the mid-to-late 1990s around a number of interconnected concerns and issues that now comprise PiE. Major objectives are to provide a new perspective to the topic, to facilitate more efficient and effective review of the literature by others, and to recognize the more significant, seminal contributions to the advancement of PiE as a field of research. Some of the most highly cited articles in all of environmental science now involve PiE. As of April 2015, a core group of 385 PiE articles had each received at least 200 citations; one had received 5424 citations. But hundreds of additional articles also played important roles in the evolution and advancement of the field.

  16. Quadriceps and patellar tendon pie-crusting as a treatment for limited flexion in total knee arthroplasty.

    PubMed

    Burge, J Ross; Sanchez, Hugo B; Wagner, Russell A

    2014-04-01

    The pie-crusting method of ligament and tendon lengthening has been used successfully in various tissues but is not reported in the literature as an option for patellar or quadriceps tendons to address flexion limitation. Our case report discusses a patient with longstanding flexion limitation who underwent primary total knee arthroplasty. The report reviews the literature on intraoperative treatments, which primarily pertains to the condition of patella baja, and demonstrates that the pie-crusting technique should be included as a treatment option for a tight extensor mechanism while having some advantages over tibial tubercle osteotomy or Z-plasty.

  17. EC as PIE: five criteria for executing a successful DNP final project.

    PubMed

    Waldrop, Julee; Caruso, Diane; Fuchs, Mary Ann; Hypes, Kathe

    2014-01-01

    The goal of doctor of nursing practice (DNP) programs should be to produce nurses that are uniquely prepared to bridge the gap between the discovery of new knowledge and the scholarship of translation, application, and integration of this new knowledge in practice (American Association of Colleges of Nursing [AACN], 2006). However, there is concern over the variability in DNP programs and expected outcomes. The aim of this article is to describe a 5-point system of evaluation to determine whether a DNP final project meets the outcomes of the AACN Essentials of Doctoral Education in Advanced Nursing Practice (2006) in a comprehensive and rigorous way. In brief, the five criteria that must be met are represented by the acronym EC as PIE (E = Enhances; C = Culmination; P = Partnerships; I = Implements; E = Evaluates). Each criterion must be present and come together to form one complete "pie" representing evidence-based practice that is robust and innovative, culminating in a rigorous doctoral level DNP final project. In addition, we provide detailed examples of how these standards are currently being successfully implemented and discuss additional possibilities.

  18. Pie waste - A component of food waste and a renewable substrate for producing ethanol.

    PubMed

    Magyar, Margaret; da Costa Sousa, Leonardo; Jayanthi, Singaram; Balan, Venkatesh

    2017-02-17

    Sugar-rich food waste is a sustainable feedstock that can be converted into ethanol without an expensive thermochemical pretreatment that is commonly used in first and second generation processes. In this manuscript we have outlined the pie waste conversion to ethanol through a two-step process, namely, enzyme hydrolysis using commercial enzyme products mixtures and microbial fermentation using yeast. Optimized enzyme cocktail was found to be 45% alpha amylase, 45% gamma amylase, and 10% pectinase at 2.5mg enzyme protein/g glucan produced a hydrolysate with high glucose concentration. All three solid loadings (20%, 30%, and 40%) produced sugar-rich hydrolysates and ethanol with little to no enzyme or yeast inhibition. Enzymatic hydrolysis and fermentation process mass balance was carried out using pie waste on a 1000g dry weight basis that produced 329g ethanol at 20% solids loading. This process clearly demonstrate how food waste could be efficiently converted to ethanol that could be used for making biodiesel by reacting with waste cooking oil.

  19. The relationship of family characteristics and bipolar disorder using causal-pie models.

    PubMed

    Chen, Y-C; Kao, C-F; Lu, M-K; Yang, Y-K; Liao, S-C; Jang, F-L; Chen, W J; Lu, R-B; Kuo, P-H

    2014-01-01

    Many family characteristics were reported to increase the risk of bipolar disorder (BPD). The development of BPD may be mediated through different pathways, involving diverse risk factor profiles. We evaluated the associations of family characteristics to build influential causal-pie models to estimate their contributions on the risk of developing BPD at the population level. We recruited 329 clinically diagnosed BPD patients and 202 healthy controls to collect information in parental psychopathology, parent-child relationship, and conflict within family. Other than logistic regression models, we applied causal-pie models to identify pathways involved with different family factors for BPD. The risk of BPD was significantly increased with parental depression, neurosis, anxiety, paternal substance use problems, and poor relationship with parents. Having a depressed mother further predicted early onset of BPD. Additionally, a greater risk for BPD was observed with higher numbers of paternal/maternal psychopathologies. Three significant risk profiles were identified for BPD, including paternal substance use problems (73.0%), maternal depression (17.6%), and through poor relationship with parents and conflict within the family (6.3%). Our findings demonstrate that different aspects of family characteristics elicit negative impacts on bipolar illness, which can be utilized to target specific factors to design and employ efficient intervention programs.

  20. PIE on Safety-Tested Loose Particles from Irradiated Compact 4-4-2

    SciTech Connect

    Hunn, John D.; Gerczak, Tyler J.; Morris, Robert Noel; Baldwin, Charles A.; Montgomery, Fred C.

    2016-04-01

    Post-irradiation examination (PIE) is being performed in support of tristructural isotropic (TRISO) coated particle fuel development and qualification for High Temperature Gas-cooled Reactors (HTGRs). This work is sponsored by the Department of Energy Office of Nuclear Energy (DOE-NE) through the Advanced Reactor Technologies (ART) Office under the Advanced Gas Reactor Fuel Development and Qualification (AGR) Program. The AGR-1 experiment was the first in a series of TRISO fuel irradiation tests initiated in 2006. The AGR-1 TRISO particles and fuel compacts were fabricated at Oak Ridge National Laboratory (ORNL) in 2006 using laboratory-scale equipment and irradiated for 3 years in the Advanced Test Reactor (ATR) at Idaho National Laboratory (INL) to demonstrate and evaluate fuel performance under HTGR irradiation conditions. Post-irradiation examination was performed at INL and ORNL to study how the fuel behaved during irradiation, and to test fuel performance during exposure to elevated temperatures at or above temperatures that could occur during a depressurized conduction cooldown event. This report summarizes safety testing and post-safety testing PIE conducted at ORNL on loose particles extracted from irradiated AGR-1 Compact 4-4-2.

  1. Difficult Dialogues, Privilege and Social Justice: Uses of the Privileged Identity Exploration (PIE) Model in Student Affairs Practice

    ERIC Educational Resources Information Center

    Watt, Sherry K.

    2007-01-01

    This article will introduce the Privileged Identity Exploration (PIE) Model. This model identifies eight (8) defense modes associated with behaviors individuals display when engaged in difficult dialogues about social justice issues. Implications for the model and ways it can be used to assist facilitators as they engage participants in…

  2. A Comparison of Learning Management Systems in a School District: Searching for the Ideal Personalized Integrated Educational System (PIES)

    ERIC Educational Resources Information Center

    Yildirim, Zahide; Reigeluth, Charles M.; Kwon, Seolim; Kageto, Yuichi; Shao, Zihang

    2014-01-01

    This study explored the use of several learning management systems (LMS), their benefits, and their limitations in relation to the desired characteristics of an ideal Personalized Integrated Educational System (PIES) for the information age. A qualitative research design was used. The participants of the study were teachers, administrators, and…

  3. 49 CFR 40.373 - Before starting a PIE proceeding, does the initiating official give the service agent an...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Before starting a PIE proceeding, does the initiating official give the service agent an opportunity to correct problems? 40.373 Section 40.373 Transportation Office of the Secretary of Transportation PROCEDURES FOR TRANSPORTATION WORKPLACE DRUG AND ALCOHOL TESTING PROGRAMS Public...

  4. 49 CFR 40.369 - What is the discretion of an initiating official in starting a PIE proceeding?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false What is the discretion of an initiating official in starting a PIE proceeding? 40.369 Section 40.369 Transportation Office of the Secretary of Transportation PROCEDURES FOR TRANSPORTATION WORKPLACE DRUG AND ALCOHOL TESTING PROGRAMS Public Interest Exclusions § 40.369 What is the discretion of...

  5. [Comparative analysis of Ayrshire and Black Pied cattle breeds by histocompatibility markers].

    PubMed

    Udina, I G; Karamysheva, E E; Sulimova, G E; Pavlenko, S P; Turkova, S O; Orlova, A R; Ernst, L K

    1998-12-01

    Distribution of BoLA-A antigens and BoLA-DRB3 alleles was studied by means of the microlymphocytotoxic test (BoLA-A) and the PCR-RFLP method (BoLA-DRB3) using restriction endonucleases RSAI, HaeIII, and XhoII in Ayrshire (n = 127) and Black Pied (n = 129) cattle breeds. Comparative analysis of profiles for class I antigens revealed significant differences in the frequencies of antigens W2, W6, W10, W31, W44, W15, and W19 (P > 99%). The studied breeds also differ in the spectrum of BoLA-DRB3 alleles and distribution of their frequencies. Heterogeneous allele frequency profile was detected in Ayrshire cattle: five of 18 detected alleles (DRB3.2*7, *8, *10, *24, and *28) accounted for 77%. Allele DRB3.2*7 (37.6%), which is classed with rare alleles in Black Pied cattle is the most common in Ayrshire cattle. The observed heterozygosity level in the combined sample of Black Pied breed (0.836) is higher than in Ayrshire breed (0.070). In both breeds, the heterozygosity level was studied in the groups of healthy and ill with persistent lymphocytosis (caused by bovine leukemia virus) animals and in the group of virus carriers in Ayrshire breed. In ill animals, a decrease in the observed heterozygosity level was detected, as compared to healthy animals and the expected heterozygosity level. The observed heterozygosity level exceeds the expected one in virus carriers. The detected features of the heterozygosity level in the studied groups allow the heterozygosity level for locus BoLA-DRB3 to be considered a nonspecific factor of resistance to leukemia and are heterozygous animals to have higher resistance to bovine leukemia. The presence of a larger proportion of highly productive animals (the annual productivity of more than 7000 kg) in the group of ill Ayrshire cattle animals, as compared to healthy animals to established. To increase resistance to bovine leukemia, the obtained data indicate the importance of the control of heterozygosity level and genetic diversity for

  6. Newcastle disease in a zoo affecting demoiselle cranes (Anthropoides virgo), greater flamingos (Phoenicopterus ruber) and a pied imperial pigeon (Ducula bicolor).

    PubMed

    Kaleta, E F; Marschall, H J

    1981-07-01

    Newcastle disease virus could be isolated from demoiselle cranes (Anthropoides virgo), greater flamingos (Phoenicopterus ruber) and a pied imperial pigeon (Ducula bicolor) in chicken embryo fibroblast (CEF) cultures. All of these birds died without prominent symptoms and had no typical pathological lesions. Identification and characterisation studies of the viruses were performed in CEF cultures and embryos. Serological cross reactions could be detected between NDV strain B1 and the new isolates by haemagglutination inhibition and plaque reduction tests. Electron microscopic examination revealed particles with paramyxovirus morphology. Inoculation of susceptible cockerels resulted in severe clinical symptoms and mortality. The distribution of lesions in the digestive tract indicates that the isolated viruses are of the velogenic viscerotropic type.

  7. In vivo amelioration of endogenous antitumor autoantibodies via low-dose P4N through the LTA4H/activin A/BAFF pathway

    PubMed Central

    Lin, Yu-Ling; Tsai, Nu-Man; Hsieh, Cheng-Hao; Ho, Shu-Yi; Chang, Jung; Wu, Hsin-Yi; Hsu, Ming-Hua; Chang, Chia-Ching; Liao, Kuang-Wen; Jackson, Tiffany L. B.; Mold, David E.; Huang, Ru Chih C.

    2016-01-01

    Cancer progression is associated with the development of antitumor autoantibodies in patients’ sera. Although passive treatment with antitumor antibodies has exhibited remarkable therapeutic efficacy, inhibitory effects on tumor progression by endogenous antitumor autoantibodies (EAAs) have been limited. In this study, we show that P4N, a derivative of the plant lignan nordihydroguaiaretic acid (NDGA), enhanced the production of EAAs and inhibited tumor growth at low noncytotoxic concentrations via its immunoregulatory activity. Intratumoral injection of P4N improved the quantity and quality of EAAs, and passive transfer of P4N-induced EAAs dramatically suppressed lung metastasis formation and prolonged the survival of mice inoculated with metastatic CT26 tumor cells. P4N-induced EAAs specifically recognized two surface antigens, 78-kDa glucose-regulated protein (GRP78) and F1F0 ATP synthase, on the plasma membrane of cancer cells. Additionally, P4N treatment led to B-cell proliferation, differentiation to plasma cells, and high titers of autoantibody production. By serial induction of autocrine and paracrine signals in monocytes, P4N increased B-cell proliferation and antibody production via the leukotriene A4 hydrolase (LTA4H)/activin A/B-cell activating factor (BAFF) pathway. This mechanism provides a useful platform for studying and seeking a novel immunomodulator that can be applied in targeting therapy by improving the quantity and quality of the EAAs. PMID:27856749

  8. In vivo amelioration of endogenous antitumor autoantibodies via low-dose P4N through the LTA4H/activin A/BAFF pathway.

    PubMed

    Lin, Yu-Ling; Tsai, Nu-Man; Hsieh, Cheng-Hao; Ho, Shu-Yi; Chang, Jung; Wu, Hsin-Yi; Hsu, Ming-Hua; Chang, Chia-Ching; Liao, Kuang-Wen; Jackson, Tiffany L B; Mold, David E; Huang, Ru Chih C

    2016-11-29

    Cancer progression is associated with the development of antitumor autoantibodies in patients' sera. Although passive treatment with antitumor antibodies has exhibited remarkable therapeutic efficacy, inhibitory effects on tumor progression by endogenous antitumor autoantibodies (EAAs) have been limited. In this study, we show that P4N, a derivative of the plant lignan nordihydroguaiaretic acid (NDGA), enhanced the production of EAAs and inhibited tumor growth at low noncytotoxic concentrations via its immunoregulatory activity. Intratumoral injection of P4N improved the quantity and quality of EAAs, and passive transfer of P4N-induced EAAs dramatically suppressed lung metastasis formation and prolonged the survival of mice inoculated with metastatic CT26 tumor cells. P4N-induced EAAs specifically recognized two surface antigens, 78-kDa glucose-regulated protein (GRP78) and F1F0 ATP synthase, on the plasma membrane of cancer cells. Additionally, P4N treatment led to B-cell proliferation, differentiation to plasma cells, and high titers of autoantibody production. By serial induction of autocrine and paracrine signals in monocytes, P4N increased B-cell proliferation and antibody production via the leukotriene A4 hydrolase (LTA4H)/activin A/B-cell activating factor (BAFF) pathway. This mechanism provides a useful platform for studying and seeking a novel immunomodulator that can be applied in targeting therapy by improving the quantity and quality of the EAAs.

  9. Biomechanical validation of medial pie-crusting for soft-tissue balancing in knee arthroplasty.

    PubMed

    Mihalko, William M; Woodard, Erik L; Hebert, Casey T; Crockarell, John R; Williams, John L

    2015-02-01

    Balancing a varus knee is traditionally accomplished by releasing the medial soft-tissue sleeve off the tibia. Recently, "pie-crusting" (PC) medial structures has been described. In a biomechanical cadaver study we compared PC to traditional release (TR) to determine their effects on flexion and extension gaps. PC was done in five specimens along the anterior half of the medial soft-tissue sleeve and five along the posterior half, followed by a traditional release. In 90° flexion, valgus laxity after TR was significantly greater than after PC alone. PC of the anterior or posterior aspect of the medial soft-tissue sleeve can effect changes more in flexion than in extension, respectively. Complete TR did not provide more gap opening than PC in extension, but produced more effect in flexion.

  10. Alternate non-stop migration strategies of pied flycatchers to cross the Sahara desert

    PubMed Central

    Both, Christiaan

    2016-01-01

    Each year more than two billion songbirds cross the Sahara, but how they perform this formidable task is largely unknown. Using geolocation tracks from 27 pied flycatchers, a nocturnally migrating passerine, we show that most birds made diurnal flights in both autumn and spring. These diurnal flights were estimated to be part of non-stop flights of mostly 40–60 h. In spring, birds flew across the Sahara, while autumn migration probably circumpassed part of the desert, through a long oversea flight. Our data contradict claims that passerines cross the Sahara by intermittent flight and daytime resting. The frequent occurrence of long non-stop flights to cross the desert shows migrants' physiological abilities and poses the question why this would not be the general migration strategy to cross the Sahara. PMID:27072404

  11. Variete Technique du Lambeau Sural dans les Brulures Profondes du Pied

    PubMed Central

    Ezzoubi, M.; Ettalbi, S.; Elmounjid, S.; Fassi, J.; Benchamckha, F.J.; Sakhi, M.; Boukind, E.

    2005-01-01

    Summary Les couvertures des pertes de substance de la jambe, du talon et du pied font souvent appel au lambeau sural, qui reste, de part ses dimensions, une indication limitée. Les Auteurs présentent, à travers deux cas cliniques, une variété technique pour la levée du lambeau sural, permettant d'obtenir des palettes cutanées de grande surface avec une bonne sécurité vasculaire. C'est un lambeau fasciocutané remontant jusqu'à un centimètre du creux poplité et incluant, lors de la levée, l'aponévrose, le nerf sural, la petite veine saphène et le nerf sural latéral. PMID:21990988

  12. Optical properties of the hydrated charged silver tetramer and silver hexamer encapsulated inside the sodalite cavity of an LTA-type zeolite.

    PubMed

    Cuong, Ngo Tuan; Nguyen, Hue Minh Thi; Pham-Ho, My Phuong; Nguyen, Minh Tho

    2016-07-21

    The optical spectra in the UV-VIS region of the hydrated doubly charged tetramer Ag4(2+) and hydrated multiply charged hexamer Ag6(p+) silver clusters encapsulated inside the sodalite cavity of an LTA-type zeolite have been systematically predicted using DFT, TD-DFT and CASSCF/CASPT2 methods. The optical behaviour of the model hydrated clusters [Ag6(H2O)8(Si24H24O36)](p+) is very sensitive to their charge. Among the cations [Ag6(H2O)8(Si24H24O36)](p+), only the embedded hydrated quadruply charged silver hexamer [Ag6(H2O)8(Si24H24O36)](4+) shows a strong absorption band at ∼420 nm (blue light) and emits light in red color. The absorption spectrum of the hydrated doubly charged silver tetramer cluster [Ag4(H2O)m(Si24H24O36)](2+), which shifts slightly and steadily with the increasing amount of interacting water molecules to longer wavelengths, has a strong peak in the blue region. The water environment forces the silver tetramer to relocate into one side of the cavity instead of at its center as in the case of the non-hydrated [Ag4(Si24H24O36)](2+) cluster. Water molecules act as ligands significantly splitting the energy levels of excited states of the Ag4(2+) and Ag6(4+) clusters. This causes the absorption spectra of the clusters to broaden and the emission to shift to the green-yellow and red part of the visible region.

  13. The strategy for numerical solving of PIES without explicit calculation of singular integrals in 2D potential problems

    NASA Astrophysics Data System (ADS)

    Szerszeń, Krzysztof; Zieniuk, Eugeniusz

    2016-06-01

    The paper presents a strategy for numerical solving of parametric integral equation system (PIES) for 2D potential problems without explicit calculation of singular integrals. The values of these integrals will be expressed indirectly in terms of easy to compute non-singular integrals. The effectiveness of the proposed strategy is investigated with the example of potential problem modeled by the Laplace equation. The strategy simplifies the structure of the program with good the accuracy of the obtained solutions.

  14. Syndrome de larva migrans cutanée sur pied malformé (à propos d'un cas)

    PubMed Central

    Benbella, Imane; Khalki, Hanane; Lahmadi, Khalid; Kouara, Sara; Abbadi, Abderrahim; Er-rami, Mohammed

    2016-01-01

    Le syndrome de larva migrans cutanée est une dermite sous cutanée causée par des larves d'ankylostomes d'animaux en impasse parasitaire chez l'homme. L'infestation transcutanée est favorisée par le contact avec le sol contaminé par les larves du parasite. Nous rapportons le cas d'un nourrisson de 15 mois, originaire de Guinée-Bissau, atteint d'un syndrome de larva migrans cutanée sur un pied malformé. Cette malformation sous forme d'une syndactylie associée à une tuméfaction du pied, était à l'origine d'un retard d'acquisition de la station debout. De même, on a rapporté une notion de pieds nus, vue la difficulté de chausser le pied malformé du patient. Tous ces facteurs auraient contribués à favoriser l'infestation du malade par les larves du nématode. PMID:27217876

  15. Miniature Gas Chromatograph (GC): Penning Ionization Electron Spectroscopy (PIES) Instrument for the Trace Analyses of Extraterrestrial Environments

    NASA Technical Reports Server (NTRS)

    Kojiro, Daniel R.; Sheverev, Valery A.; Holland, Paul M.; Takeuchi, Norishige

    2006-01-01

    In situ exploration of the solar system to identify its early chemistry as preserved in icy bodies and to look for compelling evidence of astrobiology will require new technology for chemical analysis. Chemical measurements in space flight environments highlight the need for a high level of positive identification of chemical compounds, since re-measurement by alternative techniques for confirmation will not be feasible. It also may not be possible to anticipate all chemical species that are observed, and important species may be present only at trace levels where they can be masked by complex chemical backgrounds. Up to now, the only techniques providing independent sample identification of GC separated components across a wide range of chemical species have been Mass Spectrometry (MS) and Ion Mobility Spectrometry (IMS). We describe here the development of a versatile and robust miniature GC detector based on Penning Ionization Electron Spectroscopy (PIES), for use with miniature GC systems being developed for planetary missions. PIES identifies the sample molecule through spectra related to its ionization potential. The combination of miniature GC technology with the primary identification capabilities of PIES provides an analytical approach ideal for planetary analyses.

  16. Monitoring lipid anchor organization in cell membranes by PIE-FCCS.

    PubMed

    Triffo, Sara B; Huang, Hector H; Smith, Adam W; Chou, Eldon T; Groves, Jay T

    2012-07-04

    This study examines the dynamic co-localization of lipid-anchored fluorescent proteins in living cells using pulsed-interleaved excitation fluorescence cross-correlation spectroscopy (PIE-FCCS) and fluorescence lifetime analysis. Specifically, we look at the pairwise co-localization of anchors from lymphocyte cell kinase (LCK: myristoyl, palmitoyl, palmitoyl), RhoA (geranylgeranyl), and K-Ras (farnesyl) proteins in different cell types. In Jurkat cells, a density-dependent increase in cross-correlation among RhoA anchors is observed, while LCK anchors exhibit a more moderate increase and broader distribution. No correlation was detected among K-Ras anchors or between any of the different anchor types studied. Fluorescence lifetime data reveal no significant Förster resonance energy transfer in any of the data. In COS 7 cells, minimal correlation was detected among LCK or RhoA anchors. Taken together, these observations suggest that some lipid anchors take part in anchor-specific co-clustering with other existing clusters of native proteins and lipids in the membrane. Importantly, these observations do not support a simple interpretation of lipid anchor-mediated organization driven by partitioning based on binary lipid phase separation.

  17. The why of practice: utilizing PIE to analyze social work practice in Australian hospitals.

    PubMed

    Nilsson, David; Joubert, Lynette; Holland, Lucy; Posenelli, Sonia

    2013-01-01

    This research used a collaborative approach to gain a comprehensive, quantitative understanding of the breadth and depth of the social work role in health care. Data was collected from individual interviews with all employed hospital social workers (N = 120) across five Melbourne, Australia health networks about their most recently completed case. This data was coded using a revised version of the Karls and Wandrei (1994) Person-in-Environment (PIE) tool to retrospectively analyze the reasons for social work involvement over the course of the case. The findings demonstrate that the hospital social work role is multidimensional across a number of domains but centers predominantly on assisting clients and their significant others with issues of altered social roles and functioning; particularly in relation to role responsibility, dependency, and managing associated role-change losses. The findings of this study will assist hospital social workers, managers, and academics to better describe and effectively undertake this complex work. These findings will also assist in the development of professional training and education to up-skill social workers who operate within this complex setting.

  18. Pie-like electrode design for high-energy density lithium-sulfur batteries

    NASA Astrophysics Data System (ADS)

    Li, Zhen; Zhang, Jin Tao; Chen, Yu Ming; Li, Ju; Lou, Xiong Wen (David)

    2015-11-01

    Owing to the overwhelming advantage in energy density, lithium-sulfur (Li-S) battery is a promising next-generation electrochemical energy storage system. Despite many efforts in pursuing long cycle life, relatively little emphasis has been placed on increasing the areal energy density. Herein, we have designed and developed a `pie' structured electrode, which provides an excellent balance between gravimetric and areal energy densities. Combining lotus root-like multichannel carbon nanofibers `filling' and amino-functionalized graphene `crust', the free-standing paper electrode (S mass loading: 3.6 mg cm-2) delivers high specific capacity of 1,314 mAh g-1 (4.7 mAh cm-2) at 0.1 C (0.6 mA cm-2) accompanied with good cycling stability. Moreover, the areal capacity can be further boosted to more than 8 mAh cm-2 by stacking three layers of paper electrodes with S mass loading of 10.8 mg cm-2.

  19. Pie-like electrode design for high-energy density lithium-sulfur batteries.

    PubMed

    Li, Zhen; Zhang, Jin Tao; Chen, Yu Ming; Li, Ju; Lou, Xiong Wen David

    2015-11-26

    Owing to the overwhelming advantage in energy density, lithium-sulfur (Li-S) battery is a promising next-generation electrochemical energy storage system. Despite many efforts in pursuing long cycle life, relatively little emphasis has been placed on increasing the areal energy density. Herein, we have designed and developed a 'pie' structured electrode, which provides an excellent balance between gravimetric and areal energy densities. Combining lotus root-like multichannel carbon nanofibers 'filling' and amino-functionalized graphene 'crust', the free-standing paper electrode (S mass loading: 3.6 mg cm(-2)) delivers high specific capacity of 1,314 mAh g(-1) (4.7 mAh cm(-2)) at 0.1 C (0.6 mA cm(-2)) accompanied with good cycling stability. Moreover, the areal capacity can be further boosted to more than 8 mAh cm(-2) by stacking three layers of paper electrodes with S mass loading of 10.8 mg cm(-2).

  20. Temporal regularity increases with repertoire complexity in the Australian pied butcherbird's song

    PubMed Central

    Taylor, Hollis; Scharff, Constance; Rothenberg, David; Parra, Lucas C.; Tchernichovski, Ofer

    2016-01-01

    Music maintains a characteristic balance between repetition and novelty. Here, we report a similar balance in singing performances of free-living Australian pied butcherbirds. Their songs include many phrase types. The more phrase types in a bird's repertoire, the more diverse the singing performance can be. However, without sufficient temporal organization, avian listeners may find diverse singing performances difficult to perceive and memorize. We tested for a correlation between the complexity of song repertoire and the temporal regularity of singing performance. We found that different phrase types often share motifs (notes or stereotyped groups of notes). These shared motifs reappeared in strikingly regular temporal intervals across different phrase types, over hundreds of phrases produced without interruption by each bird. We developed a statistical estimate to quantify the degree to which phrase transition structure is optimized for maximizing the regularity of shared motifs. We found that transition probabilities between phrase types tend to maximize regularity in the repetition of shared motifs, but only in birds of high repertoire complexity. Conversely, in birds of low repertoire complexity, shared motifs were produced with less regularity. The strong correlation between repertoire complexity and motif regularity suggests that birds possess a mechanism that regulates the temporal placement of shared motifs in a manner that takes repertoire complexity into account. We discuss alternative musical, mechanistic and ecological explanations to this effect. PMID:27703699

  1. [EEG in altricial pied flycatcher nestlings during the functional sates related with natural behavior cycle].

    PubMed

    Korneeva, E V; Aleksandrov, L I; Khramov, A E; Sitnikova, E Iu; Raevskiĭ, V V

    2014-01-01

    Electrical brain activity accompanying various forms of behavior was studied in 11-day-old pied flycatcher nestlings. Wavelet analysis of EEG, recorded from symmetrical areas of caudomedial nidopallium (higher avian auditory center) during rest, passive and active wakefulness and movements showed that the major rhythmical EEG component was confined to low-frequency range in all four states. The significant difference from other states was observed only during movements: spectral power in the range of 1-3 Hz decreased while that in the range of 5-20 Hz--increased. The range of 3-5 Hz revealed, in all functional states, the interhemispheric asymmetry of spectral power that could be due to asymmetrical embryonic development of avian visual projections. Active wakefulness and movements were characterized by high positive correlations between spectral power in right and left hemispheres. During rest this correlation was negative. The correlation values during passive wakefulness and rest were rather low that could indicate disintegration of neural connections.

  2. Pie-like electrode design for high-energy density lithium–sulfur batteries

    PubMed Central

    Li, Zhen; Zhang, Jin Tao; Chen, Yu Ming; Li, Ju; Lou, Xiong Wen (David)

    2015-01-01

    Owing to the overwhelming advantage in energy density, lithium–sulfur (Li–S) battery is a promising next-generation electrochemical energy storage system. Despite many efforts in pursuing long cycle life, relatively little emphasis has been placed on increasing the areal energy density. Herein, we have designed and developed a ‘pie' structured electrode, which provides an excellent balance between gravimetric and areal energy densities. Combining lotus root-like multichannel carbon nanofibers ‘filling' and amino-functionalized graphene ‘crust', the free-standing paper electrode (S mass loading: 3.6 mg cm−2) delivers high specific capacity of 1,314 mAh g−1 (4.7 mAh cm−2) at 0.1 C (0.6 mA cm−2) accompanied with good cycling stability. Moreover, the areal capacity can be further boosted to more than 8 mAh cm−2 by stacking three layers of paper electrodes with S mass loading of 10.8 mg cm−2. PMID:26608228

  3. Preparation, crystal structure, and thermal stability of the cadmium sulfide nanoclusters Cd6S44+ and Cd2Na2S4+in the sodalite cavities of zeolite A (LTA).

    PubMed

    Kim, Seok Han; Heo, Nam Ho; Kim, Ghyung Hwa; Hong, Suk Bong; Seff, Karl

    2006-12-28

    The crystal structure and thermal stability of two cadmium sulfide nanoclusters prepared in zeolite A (LTA) have been studied by XPS, TGA, and single-crystal and powder XRD. The crystal structures of Cd2.4Na3.2(Cd6S4)0.4(Cd2Na2S)0.6(H2O)> or =5.8[Si12Al12O48]-LTA (a = 12.2919(7) A, crystal 1 (hydrated)) and /Cd4Na2(Cd2O)(Na2O)/[Si12Al12O48]-LTA (a = 12.2617(4) A, crystal 2 (dehydrated)) were determined by single-crystal methods in the cubic space group Pm3m at 294(1) K. Crystal 1 was prepared by ion exchange of Na12-LTA in an aqueous stream 0.05 M in Cd2+, followed by washing in a stream of water, followed by reaction in an aqueous stream 0.05 M in Na2S. Crystal 2 was made by dehydrating crystal 1 at 623 K and 1 x 10(-6) Torr for 3 days. In crystal 1, Cd6S4(4+) nanoclusters were found in and extending out of about 40% of the sodalite cavities. Central to each Cd6S4(4+) cluster is a Cd4S4 unit (interpenetrating Cd2+ and S2- tetrahedra with near Td symmetry, Cd-S = 2.997(24) A, Cd-S-Cd = 113.8(12) degrees, and S-Cd-S = 58.1(24) degrees). Each of the two remaining Cd2+ ions bonds radially through a 6-ring of the zeolite framework to a sulfide ion of this Cd4S4 unit (Cd-S = 2.90(8) A). In each of the remaining 60% of the sodalite cavities of crystal 1, a planar Cd2Na2S4+ cluster was found (Cd-S/Na-S = 2.35(5)/2.56(14) A and Cd-S-Cd/Na-S-Na = 122(5)/92(7) degrees). Cd6S4(4+) and Cd2Na2S4+ are stable within the zeolite up to about 700 K in air. Upon vacuum dehydration at 623 K, all sulfur was lost (crystal 2). Instead as anions, only two oxide ions remain per sodalite unit. One bridges between two Cd2+ ions (Cd2O2+, Cd-O = 2.28(3) A) and the other between two Na+ ions (Na2O, Na-O = 2.21(10) A).

  4. NASA's Long-Term Archive (LTA) of ICESat Data at the National Snow and Ice Data Center (NSIDC)

    NASA Astrophysics Data System (ADS)

    Fowler, D. K.; Moses, J. F.; Dimarzio, J. P.; Webster, D.

    2011-12-01

    Data Stewardship, preservation, and reproducibility are becoming principal parts of a data manager's work. In an era of distributed data and information systems, where the host location ought to be transparent to the internet user, it is of vital importance that organizations make a commitment to both current and long-term goals of data management and the preservation of scientific data. NASA's EOS Data and Information System (EOSDIS) is a distributed system of discipline-specific archives and mission-specific science data processing facilities. Satellite missions and instruments go through a lifecycle that involves pre-launch calibration, on-orbit data acquisition and product generation, and final reprocessing. Data products and descriptions flow to the archives for distribution on a regular basis during the active part of the mission. However there is additional information from the product generation and science teams needed to ensure the observations will be useful for long term climate studies. Examples include ancillary input datasets, product generation software, and production history as developed by the team during the course of product generation. These data and information will need to be archived after product data processing is completed. Using inputs from the USGCRP Workshop on Long Term Archive Requirements (1998), discussions with EOS instrument teams, and input from the 2011 ESIPS Federation meeting, NASA is developing a set of Earth science data and information content requirements for long term preservation that will ultimately be used for all the EOS missions as they come to completion. Since the ICESat/GLAS mission is one of the first to come to an end, NASA and NSIDC are preparing for long-term support of the ICESat mission data now. For a long-term archive, it is imperative that there is sufficient information about how products were prepared in order to convince future researchers that the scientific results are accurate, understandable

  5. Meaningful call combinations and compositional processing in the southern pied babbler.

    PubMed

    Engesser, Sabrina; Ridley, Amanda R; Townsend, Simon W

    2016-05-24

    Language's expressive power is largely attributable to its compositionality: meaningful words are combined into larger/higher-order structures with derived meaning. Despite its importance, little is known regarding the evolutionary origins and emergence of this syntactic ability. Although previous research has shown a rudimentary capability to combine meaningful calls in primates, because of a scarcity of comparative data, it is unclear to what extent analog forms might also exist outside of primates. Here, we address this ambiguity and provide evidence for rudimentary compositionality in the discrete vocal system of a social passerine, the pied babbler (Turdoides bicolor). Natural observations and predator presentations revealed that babblers produce acoustically distinct alert calls in response to close, low-urgency threats and recruitment calls when recruiting group members during locomotion. On encountering terrestrial predators, both vocalizations are combined into a "mobbing sequence," potentially to recruit group members in a dangerous situation. To investigate whether babblers process the sequence in a compositional way, we conducted systematic experiments, playing back the individual calls in isolation as well as naturally occurring and artificial sequences. Babblers reacted most strongly to mobbing sequence playbacks, showing a greater attentiveness and a quicker approach to the loudspeaker, compared with individual calls or control sequences. We conclude that the sequence constitutes a compositional structure, communicating information on both the context and the requested action. Our work supports previous research suggesting combinatoriality as a viable mechanism to increase communicative output and indicates that the ability to combine and process meaningful vocal structures, a basic syntax, may be more widespread than previously thought.

  6. Meaningful call combinations and compositional processing in the southern pied babbler

    PubMed Central

    Engesser, Sabrina; Ridley, Amanda R.; Townsend, Simon W.

    2016-01-01

    Language’s expressive power is largely attributable to its compositionality: meaningful words are combined into larger/higher-order structures with derived meaning. Despite its importance, little is known regarding the evolutionary origins and emergence of this syntactic ability. Although previous research has shown a rudimentary capability to combine meaningful calls in primates, because of a scarcity of comparative data, it is unclear to what extent analog forms might also exist outside of primates. Here, we address this ambiguity and provide evidence for rudimentary compositionality in the discrete vocal system of a social passerine, the pied babbler (Turdoides bicolor). Natural observations and predator presentations revealed that babblers produce acoustically distinct alert calls in response to close, low-urgency threats and recruitment calls when recruiting group members during locomotion. On encountering terrestrial predators, both vocalizations are combined into a “mobbing sequence,” potentially to recruit group members in a dangerous situation. To investigate whether babblers process the sequence in a compositional way, we conducted systematic experiments, playing back the individual calls in isolation as well as naturally occurring and artificial sequences. Babblers reacted most strongly to mobbing sequence playbacks, showing a greater attentiveness and a quicker approach to the loudspeaker, compared with individual calls or control sequences. We conclude that the sequence constitutes a compositional structure, communicating information on both the context and the requested action. Our work supports previous research suggesting combinatoriality as a viable mechanism to increase communicative output and indicates that the ability to combine and process meaningful vocal structures, a basic syntax, may be more widespread than previously thought. PMID:27155011

  7. A bipartite U1 site represses U1A expression by synergizing with PIE to inhibit nuclear polyadenylation.

    PubMed

    Guan, Fei; Caratozzolo, Rose M; Goraczniak, Rafal; Ho, Eric S; Gunderson, Samuel I

    2007-12-01

    U1A protein negatively autoregulates itself by polyadenylation inhibition of its own pre-mRNA by binding as two molecules to a 3'UTR-located Polyadenylation Inhibitory Element (PIE). The (U1A)2-PIE complex specifically blocks U1A mRNA biosynthesis by inhibiting polyA tail addition, leading to lower mRNA levels. U1 snRNP bound to a 5'ss-like sequence, which we call a U1 site, in the 3'UTRs of certain papillomaviruses leads to inhibition of viral late gene expression via a similar mechanism. Although such U1 sites can also be artificially used to potently silence reporter and endogenous genes, no naturally occurring U1 sites have been found in eukaryotic genes. Here we identify a conserved U1 site in the human U1A gene that is, unexpectedly, within a bipartite element where the other part represses the U1 site via a base-pairing mechanism. The bipartite element inhibits U1A expression via a synergistic action with the nearby PIE. Unexpectedly, synergy is not based on stabilizing binding of the inhibitory factors to the 3'UTR, but rather is a property of the larger ternary complex. Inhibition targets the biosynthetic step of polyA tail addition rather than altering mRNA stability. This is the first example of a functional U1 site in a cellular gene and of a single gene containing two dissimilar elements that inhibit nuclear polyadenylation. Parallels with other examples where U1 snRNP inhibits expression are discussed. We expect that other cellular genes will harbor functional U1 sites.

  8. Candidate genes for colour and vision exhibit signals of selection across the pied flycatcher (Ficedula hypoleuca) breeding range.

    PubMed

    Lehtonen, P K; Laaksonen, T; Artemyev, A V; Belskii, E; Berg, P R; Both, C; Buggiotti, L; Bureš, S; Burgess, M D; Bushuev, A V; Krams, I; Moreno, J; Mägi, M; Nord, A; Potti, J; Ravussin, P-A; Sirkiä, P M; Sætre, G-P; Winkel, W; Primmer, C R

    2012-04-01

    The role of natural selection in shaping adaptive trait differentiation in natural populations has long been recognized. Determining its molecular basis, however, remains a challenge. Here, we search for signals of selection in candidate genes for colour and its perception in a passerine bird. Pied flycatcher plumage varies geographically in both its structural and pigment-based properties. Both characteristics appear to be shaped by selection. A single-locus outlier test revealed 2 of 14 loci to show significantly elevated signals of divergence. The first of these, the follistatin gene, is expressed in the developing feather bud and is found in pathways with genes that determine the structure of feathers and may thus be important in generating variation in structural colouration. The second is a gene potentially underlying the ability to detect this variation: SWS1 opsin. These two loci were most differentiated in two Spanish pied flycatcher populations, which are also among the populations that have the highest UV reflectance. The follistatin and SWS1 opsin genes thus provide strong candidates for future investigations on the molecular basis of adaptively significant traits and their co-evolution.

  9. Differentiation in neutral genes and a candidate gene in the pied flycatcher: using biological archives to track global climate change.

    PubMed

    Kuhn, Kerstin; Schwenk, Klaus; Both, Christiaan; Canal, David; Johansson, Ulf S; van der Mije, Steven; Töpfer, Till; Päckert, Martin

    2013-11-01

    Global climate change is one of the major driving forces for adaptive shifts in migration and breeding phenology and possibly impacts demographic changes if a species fails to adapt sufficiently. In Western Europe, pied flycatchers (Ficedula hypoleuca) have insufficiently adapted their breeding phenology to the ongoing advance of food peaks within their breeding area and consequently suffered local population declines. We address the question whether this population decline led to a loss of genetic variation, using two neutral marker sets (mitochondrial control region and microsatellites), and one potentially selectively non-neutral marker (avian Clock gene). We report temporal changes in genetic diversity in extant populations and biological archives over more than a century, using samples from sites differing in the extent of climate change. Comparing genetic differentiation over this period revealed that only the recent Dutch population, which underwent population declines, showed slightly lower genetic variation than the historic Dutch population. As that loss of variation was only moderate and not observed in all markers, current gene flow across Western and Central European populations might have compensated local loss of variation over the last decades. A comparison of genetic differentiation in neutral loci versus the Clock gene locus provided evidence for stabilizing selection. Furthermore, in all genetic markers, we found a greater genetic differentiation in space than in time. This pattern suggests that local adaptation or historic processes might have a stronger effect on the population structure and genetic variation in the pied flycatcher than recent global climate changes.

  10. A novel putative lipoprotein receptor (CasLpR) in the hemocytes of the blue crab, Callinectes sapidus: cloning and up-regulated expression after the injection of LPS and LTA.

    PubMed

    Tsutsui, Naoaki; Chung, J Sook

    2012-03-01

    The full-length cDNA encoding a putative lipoprotein receptor (CasLpR) was isolated from the hemocytes of Callinectes sapidus using 5' and 3' RACEs. The open reading frame for CasLpR contains a precursor of putative CasLpR consisting of 1710 amino acid residues including 22 amino acid residues of the signal peptide (22 amino acids). Mature CasLpR (1688 amino acids with 5.6% of phosphorylation sites) has multiple, putative functional domains: five low-density lipoprotein receptor domains in the N-terminus, and a G-protein-coupled receptor proteolysis site domain and a 7 transmembrane receptor (secretin family) domain in the C-terminus. To date, there are no proteins with a similar domain structure in the GenBank. The expression pattern of CasLpR was exclusive in hemocytes among all tested tissues obtained from a juvenile female at intermolt stage: brain, eyestalk ganglia, pericardial organs, and thoracic ganglia complex (nervous system); hepatopancreas (digestive system); heart, artery and hemocytes (circulatory system); gill and antennal gland (excretory system), hypodermis; and Y-organ (endocrine organ). There was no CasLpR expression in the ovary of an adult female. A putative function of CasLpR was examined after challenges of lipopolysaccharides (LPS) and lipoteichoic acid (LTA) in vivo using qRT-PCR assays. Animals at 24 h after injection of LPS or LTA up-regulated the expression of CasLpR in hemocytes by ∼3.5 and 1.4 folds, respectively, compared to the controls that received saline injection. LPS challenge also caused the greatest increment (∼55 folds) of heat shock protein 90 (Hsp90) expression in these samples. These data indicate that putative CasLpR and CasHsp90 may be involved in the defense system or the stress response of C. sapidus.

  11. 49 CFR 40.371 - On what information does an initiating official rely in deciding whether to start a PIE proceeding?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false On what information does an initiating official rely in deciding whether to start a PIE proceeding? 40.371 Section 40.371 Transportation Office of the Secretary of Transportation PROCEDURES FOR TRANSPORTATION WORKPLACE DRUG AND ALCOHOL TESTING PROGRAMS Public Interest Exclusions § 40.371 On...

  12. Fifteen-year population attributable fractions and causal pies of risk factors for newly developed hepatocellular carcinomas in 11,801 men in Taiwan.

    PubMed

    Liao, Shu-Fen; Yang, Hwai-I; Lee, Mei-Hsuan; Chen, Chien-Jen; Lee, Wen-Chung

    2012-01-01

    Development of hepatocellular carcinoma (HCC) is a multi-factorial process. Chronic infections with hepatitis B virus (HBV) and hepatitis C virus (HCV) are important risk factors of HCC. Host factors, such as alcohol drinking, may also play a role. This study aims to provide a synthesis view on the development of HCC by examining multiple risk factors jointly and collectively. Causal-pie modeling technique was applied to analyze a cohort of 11,801 male residents (followed up for 15 years) in Taiwan, during which a total of 298 incident HCC cases were ascertained. The rate ratios adjusted by age were further modeled by an additive Poisson regression. Population attributable fractions (PAFs) and causal-pie weights (CPWs) were calculated. A PAF indicates the magnitude of case-load reduction under a particular intervention scenario, whereas a CPW for a particular class of causal pies represents the proportion of HCC cases attributable to that class. Using PAF we observed a chance to reduce around 60% HCC risk moving from no HBV-related intervention to the total elimination of the virus. An additional ∼15% (or ∼5%) reduction can be expected, if the HBV-related intervention is coupled with an HCV-related intervention (or an anti-drinking campaign). Eight classes of causal pies were found to be significant, including four dose-response classes of HBV (total CPW=52.7%), one independent-effect class of HCV (CPW=14.4%), one HBV-alcohol interaction class (CPW=4.2%), one HBV-HCV interaction class (CPW=1.7%), and one all-unknown class (CPW=27.0%). Causal-pie modeling for HCC helps clarify the relative importance of each viral and host factor, as well as their interactions.

  13. Overflow transports in Denmark Strait and the Faroe Bank Channel derived from combined moored ADCP and PIES measurements during 2011-2014

    NASA Astrophysics Data System (ADS)

    Moritz, Martin; Jochumsen, Kerstin; Quadfasel, Detlef

    2015-04-01

    The Denmark Strait (DS) and Faroe Bank Channel (FBC) are the major pathways of dense water leaving the Arctic Mediterranean. The water formed in the Nordic Seas crosses the sills of this passages and descends into the deep North Atlantic Ocean where it becomes part of the North Atlantic Deep Water. Estimates of strength and variability of these overflows are useful to observe temporal changes and understand mechanisms that may affect the Atlantic Meridional Overturning Circulation. The velocities in the overflows have been measured with Acoustic Doppler Current Profilers (ADCPs) for almost two decades. For transport estimates the thickness of the overflow plume is typically derived from the depth of maximum velocity shear. During 2011 and 2014 Pressure Inverted Echo Sounders (PIES) were added to the mooring sites. The thickness of the plume of overflow water that is usually characterized to be denser than σΦ=27.8 kgm-3 can be estimated from hydrographic profiles that were obtained from travel time measurements of the PIES. The volume transports in DS, calculated from ADCPs only and in combination with the plume thickness derived from PIES measurements, are compared. The mean difference between both is about 3% of the total transport of 3 Sv. Nevertheless, daily estimates can differ within the same magnitude, whereas the difference of monthly estimates reduces to about 0.3 Sv. The heat transport of the overflow relative to 0° C calculated from combined PIES and ADCP measurements across the DS varies within the order of 10 TW. Estimates of transports from hydraulic control theory were derived from PIES data upstream of the sills in DS and FBC and compared to transport observations at the sills. Additionally, the variability within the vertical structure of the water column in DS and FBC are analysed.

  14. What happens in an estuary doesn't stay there: patterns of biotic connectivity resulting from long term ecological research

    USGS Publications Warehouse

    Mather, Martha E.; Finn, John T.; Kennedy, Christina G.; Deegan, Linda A.; Smith, Joseph M.

    2013-01-01

    The paucity of data on migratory connections and an incomplete understanding of how mobile organisms use geographically separate areas have been obstacles to understanding coastal dynamics. Research on acoustically tagged striped bass (Morone saxatilis) at the Plum Island Ecosystems (PIE) Long Term Ecological Research site, Massachusetts, documents intriguing patterns of biotic connectivity (i.e., long-distance migration between geographically distinct areas). First, the striped bass tagged at PIE migrated southward along the coast using different routes. Second, these tagged fish exhibited strong fidelity and specificity to PIE. For example, across multiple years, tagged striped bass resided in PIE waters for an average of 1.5-2.5 months per year (means: 51-72 days; range 2-122 days), left this estuary in fall, then returned in subsequent years. Third, this specificity and fidelity connected PIE to other locations. The fish exported nutrients and energy to at least three other coastal locations through biomass added as growth. These results demonstrate that what happens in an individual estuary can affect other estuaries. Striped bass that use tightly connected routes to feed in specific estuaries should have greater across-system impacts than fish that are equally likely to go anywhere. Consequently, variations in when, where, and how fish migrate can alter across-estuary impacts.

  15. The revised human liver cytochrome P450 "Pie": absolute protein quantification of CYP4F and CYP3A enzymes using targeted quantitative proteomics.

    PubMed

    Michaels, Scott; Wang, Michael Zhuo

    2014-08-01

    The CYP4F subfamily of enzymes has been identified recently to be involved in the metabolism of endogenous compounds (arachidonic acid and leukotriene B4), nutrients (vitamins K1 and E), and xenobiotics (pafuramidine and fingolimod). CYP4F2 and CYP4F3B are reported to be expressed in the human liver. However, absolute concentrations of these enzymes in human liver microsomes (HLMs) and their interindividual variability have yet to be determined because of the lack of specific antibodies. Here, an liquid chromatography with tandem mass spectrometry (LC-MS/MS)-based targeted quantitative proteomic approach was employed to determine the absolute protein concentrations of CYP4F2 and CYP4F3B compared with CYP3A in two panels of HLMs (n = 31). As a result, the human hepatic cytochrome P450 (P450) "pie" has been revised to include the contribution of CYP4F enzymes, which amounts to 15% of the total hepatic cytochrome P450 enzymes. CYP4F3B displayed low interindividual variability (3.3-fold) in the HLM panels whereas CYP4F2 displayed large variability (21-fold). However, CYP4F2 variability decreased to 3.4-fold if the two donors with the lowest expression were excluded. In contrast, CYP3A exhibited 29-fold interindividual variability in the same HLM panels. The proposed marker reaction for CYP4F enzymes pafuramidine/DB289 M1 formation did not correlate with CYP4F protein content, suggesting alternate metabolic pathways for DB289 M1 formation in HLMs. In conclusion, CYP4F enzymes are highly expressed in the human liver and their physiologic and pharmacologic roles warrant further investigation.

  16. [Nourseothricin (streptothricin) inactivated by plasmid pIE 636-encoded acetyltransferase: detection of N-acetyl-beta-lysine in the inactivated product].

    PubMed

    Seltmann, G

    1985-12-01

    Nourseothricin (streptothricin) can be inactivated by an acetyl transferase synthesized by E. coli strains containing plasmid pIE 636. Nourseothricin inactivated in the presence of 14C-acetyl-coenzyme A was purified and submitted to partial acidic hydrolysis. By electrophoresis of the hydrolysate a 14C-containing substance moving only slowly towards the cathode could be isolated. This substance after complete hydrolysis yields only unlabelled beta-lysine.

  17. A New Dual-Frequency Liquid Crystal Lens with Ring-and-Pie Electrodes and a Driving Scheme to Prevent Disclination Lines and Improve Recovery Time

    PubMed Central

    Kao, Yung-Yuan; Chao, Paul C.-P.

    2011-01-01

    A new liquid crystal lens design is proposed to improve the recovery time with a ring-and-pie electrode pattern through a suitable driving scheme and using dual-frequency liquid crystals (DFLC) MLC-2048. Compared with the conventional single hole-type liquid crystal lens, this new structure of the DFLC lens is composed of only two ITO glasses, one of which is designed with the ring-and-pie pattern. For this device, one can control the orientation of liquid crystal directors via a three-stage switching procedure on the particularly-designed ring-and-pie electrode pattern. This aims to eliminate the disclination lines, and using different drive frequencies to reduce the recovery time to be less than 5 seconds. The proposed DFLC lens is shown effective in reducing recovery time, and then serves well as a potential device in places of the conventional lenses with fixed focus lengths and the conventional LC lens with a single circular-hole electrode pattern. PMID:22163906

  18. A new dual-frequency liquid crystal lens with ring-and-pie electrodes and a driving scheme to prevent disclination lines and improve recovery time.

    PubMed

    Kao, Yung-Yuan; Chao, Paul C-P

    2011-01-01

    A new liquid crystal lens design is proposed to improve the recovery time with a ring-and-pie electrode pattern through a suitable driving scheme and using dual-frequency liquid crystals (DFLC) MLC-2048. Compared with the conventional single hole-type liquid crystal lens, this new structure of the DFLC lens is composed of only two ITO glasses, one of which is designed with the ring-and-pie pattern. For this device, one can control the orientation of liquid crystal directors via a three-stage switching procedure on the particularly-designed ring-and-pie electrode pattern. This aims to eliminate the disclination lines, and using different drive frequencies to reduce the recovery time to be less than 5 seconds. The proposed DFLC lens is shown effective in reducing recovery time, and then serves well as a potential device in places of the conventional lenses with fixed focus lengths and the conventional LC lens with a single circular-hole electrode pattern.

  19. Active basement uplift of Sierra Pie de Palo (Northwestern Argentina): Rates and inception from10Be cosmogenic nuclide concentrations

    NASA Astrophysics Data System (ADS)

    Siame, Lionel L.; Sébrier, Michel; Bellier, Olivier; Bourlès, Didier; Costa, Carlos; Ahumada, Emilio A.; Gardini, Carlos E.; Cisneros, Hector

    2015-06-01

    Quaternary tectonic and denudation rates are investigated for an actively growing basement anticline: the Sierra Pie de Palo range, which belongs to the Andean foreland of Northwestern Argentina (28°S-33°S). In this study, a detailed morphometric analysis of the topography is combined with in situ-produced cosmogenic10Be concentrations measured in (1) surface boulders abandoned on alluvial terraces affected by fault activity (along the north bounding fault) and growth of the basement fold (along the southeastern border), (2) bedrock outcrops corresponding to an exhumed and folded, regional erosion surface, and (3) fluvial sediments sampled at the outlets of several watersheds. Along the eastern and northern borders of the range, incision and uplift rates have been estimated at approximately 0.5 and 1 mm/yr when integrated on Holocene and Pleistocene time scales, in close agreement with both long-term (structural and basin evolution data) and short-term (GPS-derived velocity field) analyses. Cosmogenic-derived denudation and uplift rates combined with geomorphic characteristics of watersheds and river channels allows estimating the onset of the uplift at 4-6 Ma, followed by a more recent period of topographic rejuvenation at roughly 1-2 Ma, probably synchronous with steepening of the eastern and northern flanks of the anticline.

  20. Effects of pollution on land snail abundance, size and diversity as resources for pied flycatcher, Ficedula hypoleuca.

    PubMed

    Eeva, Tapio; Rainio, Kalle; Suominen, Otso

    2010-09-01

    Passerine birds need extra calcium during their breeding for developing egg shells and proper growth of nestling skeleton. Land snails are an important calcium source for many passerines and human-induced changes in snail populations may pose a severe problem for breeding birds. We studied from the bird's viewpoint how air pollution affects the shell mass, abundance and diversity of land snail communities along a pollution gradient of a copper smelter. We sampled remnant snail shells from the nests of an insectivorous passerine, the pied flycatcher, Ficedula hypoleuca, to find out how the availability of land snails varies along the pollution gradient. The total snail shell mass increased towards the pollution source but declined abruptly in the vicinity of the smelter. This spatial variation in shell mass was evident also within a single snail species and could not be wholly explained by spatially varying snail numbers or species composition. Instead, the total shell mass was related to their shell size, individuals being largest at the moderately polluted areas. Smaller shell size suggests inferior growth of snails in the most heavily polluted area. Our study shows that pollution affects the diversity, abundance (available shell mass) and individual quality of land snails, posing reproductive problems for birds that rely on snails as calcium sources during breeding. There are probably both direct pollution-related (heavy metal and calcium levels) and indirect (habitat change) effects behind the observed changes in snail populations.

  1. Foveolar Müller Cells of the Pied Flycatcher: Morphology and Distribution of Intermediate Filaments Regarding Cell Transparency.

    PubMed

    Zueva, Lidia; Golubeva, Tatiana; Korneeva, Elena; Makarov, Vladimir; Khmelinskii, Igor; Inyushin, Mikhail

    2016-04-01

    Specialized intermediate filaments (IFs) have critical importance for the clearness and uncommon transparency of vertebrate lens fiber cells, although the physical mechanisms involved are poorly understood. Recently, an unusual low-scattering light transport was also described in retinal Müller cells. Exploring the function of IFs in Müller cells, we have studied the morphology and distribution pattern of IFs and other cytoskeletal filaments inside the Müller cell main processes in the foveolar part of the avian (pied flycatcher) retina. We found that some IFs surrounded by globular nanoparticles (that we suggest are crystallines) are present in almost every part of the Müller cells that span the retina, including the microvilli. Unlike IFs implicated in the mechanical architecture of the cell, these IFs are not connected to any specific cellular membranes. Instead, they are organized into bundles, passing inside the cell from the endfeet to the photoreceptor, following the geometry of the processes, and repeatedly circumventing numerous obstacles. We believe that the presently reported data effectively confirm that the model of nanooptical channels built of the IFs may provide a viable explanation of Müller cell transparency.

  2. La place de la double arthrodèse dans la prise en charge du pied bot varus équin invétéré

    PubMed Central

    Atarraf, Karima; Arroud, Mounir; Chater, Lamiae; Afifi, My Abderrahmane

    2014-01-01

    La prise en charge du pied bot varus équin invétéré ( PBVEI) pose d’énormes problèmes thérapeutiques. La double arthrodèse sous-talienne et médio-tarsienne longtemps considérée comme la solution de sécurité pour ces déformations est encore couramment utilisée. Nous rapportons une série de 13 enfants opérés pour un pied bot varus équin invétérés (16 pieds) par Arthrodèse sous-talienne et médio tarsienne réalisée au service d'orthopédie pédiatrique du CHU Hassan II; de Fès au Maroc sur une période de 4 ans; étalée de janvier 2009 à décembre 2012. L’âge moyen de nos patients était de 12,6 ans avec prédominance féminine. L'origine congénitale était retrouvée chez 10 patients. L'atteinte était gauche chez 8 patients avec une localisation bilatérale chez 3 patients. La radiographie standard du pied de face et de profil a révélée une divergence talo-calcanéenne qui variait entre 5 et 20°, l'angle talus-1er métatarsien entre 20 et 40° (avec une moyenne de 28°) et l'angle calcanéus-5ème métatarsien entre 15° et 45° (avec une moyenne de 30°). Tous les patients ont bénéficiés d'une arthrodèse sous-talienne et médio tarsienne. Les résultats étaient satisfaisants dans 98% des cas. Le pied était plantigrade dans 9 cas, le varus de l'arrière pied persistait dans 4 pieds alors que l’équin et le varus de l'avant pied étaient notés chez 2 cas. La double arthrodèse est l'intervention idéale pour stabiliser et corriger les déformations rencontrées dans le PBVE invétéré, elle assure totalement le verrouillage du couple de torsion. Elle permet outre une correction des diverses déformations et une ré-axation de l'arrière-pied dans les 3 plans de l'espace. PMID:25829977

  3. Wavefront Control Testbed (WCT) Experiment Results

    NASA Technical Reports Server (NTRS)

    Burns, Laura A.; Basinger, Scott A.; Campion, Scott D.; Faust, Jessica A.; Feinberg, Lee D.; Hayden, William L.; Lowman, Andrew E.; Ohara, Catherine M.; Petrone, Peter P., III

    2004-01-01

    The Wavefront Control Testbed (WCT) was created to develop and test wavefront sensing and control algorithms and software for the segmented James Webb Space Telescope (JWST). Last year, we changed the system configuration from three sparse aperture segments to a filled aperture with three pie shaped segments. With this upgrade we have performed experiments on fine phasing with line-of-sight and segment-to-segment jitter, dispersed fringe visibility and grism angle;. high dynamic range tilt sensing; coarse phasing with large aberrations, and sampled sub-aperture testing. This paper reviews the results of these experiments.

  4. SplicePie: a novel analytical approach for the detection of alternative, non-sequential and recursive splicing.

    PubMed

    Pulyakhina, Irina; Gazzoli, Isabella; 't Hoen, Peter A C; Verwey, Nisha; den Dunnen, Johan T; den Dunnen, Johan; Aartsma-Rus, Annemieke; Laros, Jeroen F J

    2015-07-13

    Alternative splicing is a powerful mechanism present in eukaryotic cells to obtain a wide range of transcripts and protein isoforms from a relatively small number of genes. The mechanisms regulating (alternative) splicing and the paradigm of consecutive splicing have recently been challenged, especially for genes with a large number of introns. RNA-Seq, a powerful technology using deep sequencing in order to determine transcript structure and expression levels, is usually performed on mature mRNA, therefore not allowing detailed analysis of splicing progression. Sequencing pre-mRNA at different stages of splicing potentially provides insight into mRNA maturation. Although the number of tools that analyze total and cytoplasmic RNA in order to elucidate the transcriptome composition is rapidly growing, there are no tools specifically designed for the analysis of nuclear RNA (which contains mixtures of pre- and mature mRNA). We developed dedicated algorithms to investigate the splicing process. In this paper, we present a new classification of RNA-Seq reads based on three major stages of splicing: pre-, intermediate- and post-splicing. Applying this novel classification we demonstrate the possibility to analyze the order of splicing. Furthermore, we uncover the potential to investigate the multi-step nature of splicing, assessing various types of recursive splicing events. We provide the data that gives biological insight into the order of splicing, show that non-sequential splicing of certain introns is reproducible and coinciding in multiple cell lines. We validated our observations with independent experimental technologies and showed the reliability of our method. The pipeline, named SplicePie, is freely available at: https://github.com/pulyakhina/splicing_analysis_pipeline. The example data can be found at: https://barmsijs.lumc.nl/HG/irina/example_data.tar.gz.

  5. MOX Average Power Test 30 GWd/MT PIE: Quick Look

    SciTech Connect

    MORRIS, RN

    2001-02-14

    This report summarizes the early results of the post irradiation examination of the 30 GWd/MT MOX Average Power Test Capsules (numbers 3 and 10). The purpose of this preliminary examination is to document and monitor the progress of the MOX Average Power Test Irradiation. The capsules and their fuel pins were found to be in excellent condition. Measurement of the fission gas release fraction (about 1.50 to 2.26%), preliminary fuel stack gamma scan measurements, and preliminary fuel pin diameter measurements indicate that the fuel is behaving as expected.

  6. A patient with phonologic alexia can learn to read "much" from "mud pies"

    PubMed Central

    Lott, Susan Nitzberg; Sample, Diane M.; Oliver, Robyn T.; Lacey, Elizabeth H.; Friedman, Rhonda B.

    2008-01-01

    People with phonologic alexia often have difficulty reading functors and verbs, in addition to pseudowords. Friedman et al (2002) reported a successful treatment for phonologic alexia that paired problematic functors and verbs with easily read relays that were homophonous nouns (e.g. "be" paired with "bee"). The current study evaluates the efficacy of pairing problematic grammatical words with relays that share initial phonemes, but vary in the relationship of their final phonemes. Results showed that reading of target grammatical words improved to criterion level (90% accuracy over two consecutive probes) in all experimental conditions with shared phonology, but remained far below criterion level in control conditions. There was a significant correlation between degree of phonologic relatedness and error rate. Maintenance of the treatment effect was poor as assessed by traditional measurement, however a dramatic savings during relearning was demonstrated during a subsequent treatment phase. The finding that reading can be re-organized by pairing target words not only with homophones, but with other phonologically related relays, suggests that this approach could be applied to a wide corpus of words and, therefore, potentially be of great use clinically. We suggest, within a connectionist account, that the treatment effect results from relays priming the initial phonologic units of the targets. PMID:18513760

  7. Disuniting uniformity: a pied cladistic canvas of mtDNA haplogroup H in Eurasia.

    PubMed

    Loogväli, Eva-Liis; Roostalu, Urmas; Malyarchuk, Boris A; Derenko, Miroslava V; Kivisild, Toomas; Metspalu, Ene; Tambets, Kristiina; Reidla, Maere; Tolk, Helle-Viivi; Parik, Jüri; Pennarun, Erwan; Laos, Sirle; Lunkina, Arina; Golubenko, Maria; Barac, Lovorka; Pericic, Marijana; Balanovsky, Oleg P; Gusar, Vladislava; Khusnutdinova, Elsa K; Stepanov, Vadim; Puzyrev, Valery; Rudan, Pavao; Balanovska, Elena V; Grechanina, Elena; Richard, Christelle; Moisan, Jean-Paul; Chaventré, André; Anagnou, Nicholas P; Pappa, Kalliopi I; Michalodimitrakis, Emmanuel N; Claustres, Mireille; Gölge, Mukaddes; Mikerezi, Ilia; Usanga, Esien; Villems, Richard

    2004-11-01

    It has been often stated that the overall pattern of human maternal lineages in Europe is largely uniform. Yet this uniformity may also result from an insufficient depth and width of the phylogenetic analysis, in particular of the predominant western Eurasian haplogroup (Hg) H that comprises nearly a half of the European mitochondrial DNA (mtDNA) pool. Making use of the coding sequence information from 267 mtDNA Hg H sequences, we have analyzed 830 mtDNA genomes, from 11 European, Near and Middle Eastern, Central Asian, and Altaian populations. In addition to the seven previously specified subhaplogroups, we define fifteen novel subclades of Hg H present in the extant human populations of western Eurasia. The refinement of the phylogenetic resolution has allowed us to resolve a large number of homoplasies in phylogenetic trees of Hg H based on the first hypervariable segment (HVS-I) of mtDNA. As many as 50 out of 125 polymorphic positions in HVS-I were found to be mutated in more than one subcluster of Hg H. The phylogeographic analysis revealed that sub-Hgs H1*, H1b, H1f, H2a, H3, H6a, H6b, and H8 demonstrate distinct phylogeographic patterns. The monophyletic subhaplogroups of Hg H provide means for further progress in the understanding of the (pre)historic movements of women in Eurasia and for the understanding of the present-day genetic diversity of western Eurasians in general.

  8. Profil bactériologique du pied diabétique et son impact sur le choix des antibiotiques

    PubMed Central

    Zemmouri, Adil; Tarchouli, Mohamed; Benbouha, Abdellatif; Lamkinsi, Tarik; Bensghir, Mustapha; Elouennass, Mostafa; Haimeur, Cherqui

    2015-01-01

    Introduction Analyse du profil bactériologique des pieds diabétiques pris en charge à l'hôpital militaire de Rabat et son influence sur l'antibiothérapie de première intention. Méthodes Etude prospective non randomisée étalée sur 18 mois, ayant concerné 105 patients. Après recueil des données et en attente des résultats bactériologiques nos patients ont été divisés en deux groupes: un groupe a été mis sous Amoxicilline + Acide clavulanique + Gentamycine (59 patients) et un groupe sous Ertapénème±Gentamycine (46 patients). Résultats L’étude a regroupé 85 hommes et 20 femmes (sexe ratio = 4.26). L’âge moyen est de 64.4 ans. La gangrène a été observée chez 79% des malades; elle était humide-donc surinfectée en principe- dans 43% des cas. Par ailleurs, 67% des malades ont un chiffre de globules blancs 12000 définissant une infection sévère. L'ostéolyse a été mise en évidence chez 27% de nos patients. Parmi les différentes techniques de prélèvements: 81% ont été profonds dont 21% de biopsie osseuse per opératoire et 14% de prélèvements combinés. 42% de ces prélèvements sont poly microbiens et 21% sont stériles. Les résultats bactériologiques viennent confirmer la prédominance des bactéries aérobies à Gram positif. Le taux de remplacement de l'Ertapénème est de 22% contre un taux de 50% pour l'Amoxiclav. Conclusion L'antibiothérapie ne doit être instaurée qu'en cas d'infection du pied diabétique diagnostiquée sur les critères cliniques établis par les consensus internationaux récents. Le respect des mesures de lutte contre la diffusion de la résistance bactérienne s'avère primordiale. PMID:27386024

  9. Sharing Smaller Pies.

    ERIC Educational Resources Information Center

    Bender, Tom

    This paper details the unfavorable predicament of the United States as a consequence of using much of its own non-renewable material and energy resources. As a consequence, the United States will soon be subject to the political and economic conditions imposed upon it by other nations. The United States must begin to implement adjustments to the…

  10. Sweetie Pie Thornless Blackberry

    Technology Transfer Automated Retrieval System (TEKTRAN)

    ‘Sweetie Pie’ is a new thornless blackberry (Rubus L. subg. Watson) cultivar developed and released by the USDA-ARS Thad Cochran Southern Horticultural Laboratory. ‘Sweetie Pie’ is a vigorous, semi-erect blackberry that produces moderate yields of sweet high quality fruit having excellent flavor, ...

  11. Aerodynamics and Hovering Control of LTA Vehicles

    DTIC Science & Technology

    1977-05-01

    Cylinders (From Reference 7). 28 ~~0 0 - iI- ~43 0 C*4 JoJ o Di 29rtf IrI ALLEN ( NACA REPT 1048) f ( k a ~~ 01 WHER IS MAX.NEGATIVEdx2 FUR2...size, the propulsive power will decrease as che propeller remote inlet velocity V, decreases. Hence, a wake-immersed propeller can produce the same...M.: "The Aerodynamic Forces on Airship Hulls", NACA Report 184, 1924. 2. Milne-Thompson: THEORETICAL HYDRODYNAMICS, MacMillan, 1955. 3. Koebn, N. E

  12. Basic relationships for LTA technical analysis

    NASA Technical Reports Server (NTRS)

    Ausrotas, R. A.

    1975-01-01

    An introduction to airship performance is presented. Static lift equations are shown which, when combined with power requirements for conventional airships, allow parametric studies of range, payload, speed and airship size. It is shown that very large airships are required to attain reasonable speeds at transoceanic ranges.

  13. [Visual input affects the expression of the early genes c-Fos and ZENK in auditory telencephalic centers of pied flycatcher nestlings during the acoustically-guided freezing].

    PubMed

    Korneeva, E V; Tiunova, A A; Aleksandrov, L I; Golubeva, T B; Anokhin, K V

    2014-01-01

    The present study analyzed expression of transcriptional factors c-Fos and ZENK in 9-day-old pied flycatcher nestlings' (Ficedula hypoleuca) telencephalic auditory centers (field L, caudomedial nidopallium and caudomedial mesopallium) involved in the acoustically-guided defense behavior. Species-typical alarm call was presented to the young in three groups: 1--intact group (sighted control), 2--nestlings visually deprived just before the experiment for a short time (unsighted control) 3--nestlings visually deprived right after hatching (experimental deprivation). Induction of c-Fos as well as ZENK in nestlings from the experimental deprivation group was decreased in both hemispheres as compared with intact group. In the group of unsighted control, only the decrease of c-Fos induction was observed exclusively in the right hemisphere. These findings suggest that limitation of visual input changes the population of neurons involved into the acoustically-guided behavior, the effect being dependant from the duration of deprivation.

  14. Synchrotron radiation as a tool for in situ investigation of extraterrestrial grains in low-density collectors: application to the analyses of the PIE polymid foams targets

    NASA Astrophysics Data System (ADS)

    Borg, J.; Quirico, E.; Simionovici, A.; Raynal, P.-I.; Chevallier, P.; Langevin, Y.

    2002-08-01

    The Particle Impact Experiment (PIE) was flown for 11 months outside the MIR station in 1996-97. The grains, both of extraterrestrial and terrestrial origins, captured in the low-density foam collectors, were investigated for using Synchrotron X-ray microfluorescence (SXμF) techniques, developed at LURE (Orsay, France) and ESRF (Grenoble, France). The positions of grains a few microns large are known at better than 10 μm. Chemical identification is arduous; only Z>20 elements are identified and, for the heavy elements, only a rough estimate of their abundances inside the grains can be given. We use the Fe/Ni ratio as the criterion allowing to distinguish between terrestrial orbital debris (OD) and extraterrestrial grains. In the 60 cm2 of foam analyzed by this technique, we identified two or three probable extraterrestrial grains and confirmed the existence of an OD cloud, rich in Fe-Ni alloys, crossed by the MIR station. SXμF is a powerful, non-destructive, technique of in situ identification of absorbing grains trapped in a material otherwise transparent to X-rays. It is the only analytical procedure for foams, opaque to visible light. For aerogels, exposed in many space missions and used as grain collectors in the STARDUST mission, the grains positions can be known after an optical scanning; SXμF appears as the last step for the high resolution in situ identification (size, shape, chemical composition) of the grain before its eventual extraction by microtunneling techniques.

  15. [Estimation of heritability and repeatability of resting metabolic rate in birds, with free-living pied flycatchers Ficedula hypoleuca (Aves: Passeriformes) as an example].

    PubMed

    Bushuev, A V; Kerimov, A B; Ivankina, E V

    2010-01-01

    Estimates of a trait heritability and repeatability can get at an idea of its usefulness for being an individual characteristic and its ability to change under selection pressure. Heritability and repeatability of energetic parameters still poorly studied in birds. The most important physiological characteristic of homoiotherms is resting metabolic rate (RMR), which, in the absence of productive processes, does not exceed basal metabolic rate (BMR). We estimated BMR repeatability in free-living pied flycatchers in Moscow Region (55 degrees 44' N, 36 degrees 51' E; 1992-2008) and Tomsk (56 degrees 20' N, 84 degrees 56' E; 2008-2009) populations over intervals from 40 days to 3 years. In Moscow Region population, BMR repeatability amounted to tau = 0.34 +/- 0.10 (n=80) if measured over 1 year interval, tau = 0.60 +/- 0.15 (n=19) if measured over 2 years interval, and tau = 0.85 +/- 0.13 (n=6) if measured over 3 years interval providing that consecutive BMR measurements were done in the same period of reproductive season. In Tomsk population, BMR repeatability, measured over 1 year interval, amounted to tau = 0.49 +/- 0.11 (n=50). Repeatability is a measure of a trait constancy and sets the upper limit of its heritability. To estimate RMR heritability, cross-fostering experiments have been conducted in 2003-2005 with flycatchers of Moscow Region population. RMR of chicks positively correlated with BMR of their biological fathers, whereas such correlation in metabolic rates between chicks and their foster fathers was absent. The RMR heritability estimate turned out to be h2 = 0.43 +/- 0.17 (n=210). The obtained estimates of heritability and repeatability of fundamental energetic traits are rather high for physiological features. This suggests the existence of a potential for direct selection on BMR and evolutionary stable diversity of avian populations with regard to basal metabolic rate.

  16. Correlation Between the CYP2C19 Phenotype Status and the Results of Three Different Platelet Function Tests in Cardiovascular Disease Patients Receiving Antiplatelet Therapy: An Emphasis on Newly Introduced Platelet Function Analyzer-200 P2Y Test

    PubMed Central

    Li, Shuhua; Choi, Jae-Lim; Guo, Long Zhe; Goh, Ri-Young; Kim, Bo-Ram; Woo, Kwang-Sook; Kim, Moo-Hyun

    2016-01-01

    Background An association has been reported between CYP2C19 polymorphism and the altered antiplatelet activity of clopidogrel. We investigated this association using the newly introduced platelet function analyzer (PFA)-200 (INNOVANCE PFA-200 System; Siemens Healthcare, Germany) P2Y test. Methods Polymorphisms of CYP2C19*2, *3, *17 and the degree of inhibition of platelet function were determined in 83 patients. Three different platelet function tests were used to evaluate the degree of platelet inhibition and to check the association with genotype. Results The post-procedure PFA-200 values of extensive metabolizers (EM) patients (285.3±38.8) were higher than those of intermediate metabolizers (IM) and poor metabolizers (PM) patients (227.7±98.3 and 133.7±99.2, respectively; P=0.024). Light transmittance aggregometry (LTA) and the VerifyNow system showed that the post-procedure values for EM patients were lower than those of IM and PM patients (LTA: 24.4±15.7, 34.1±17.6, and 42.2±16.9, respectively, P<0.001; VerifyNow: 133.2±60.5, 171.5±42.6, and 218.7±59.3, respectively, P<0.001). The high residual platelet reactivity (HPR) rates were significantly different among the EM, IM, and PM groups using PFA-200 (PM:IM:EM=82.4:40.6:11.8, P<0.001). Conclusions Approximately, 59.0% of Korean patients with cardiovascular disease receiving clopidogrel had CYP2C19 loss-of-function genotypes classified as IM or PM, and the frequency was similar to the data from Asian people. The PFA-200, LTA, and VerifyNow platelet function tests revealed evidence of a significant association between the efficacy of clopidogrel and CYP2C19 genotypes. PMID:26522758

  17. Genetic correlations between type and test-day milk yield in small dual-purpose cattle populations: The Aosta Red Pied breed as a case study.

    PubMed

    Mazza, Serena; Guzzo, Nadia; Sartori, Cristina; Mantovani, Roberto

    2016-10-01

    This study aimed at estimating the relationships between linear type traits and milk production in the dual-purpose Aosta Red Pied (ARP) cattle breed, by expressing type traits as factor scores with the same biological meaning of the individual traits. Factor analysis was applied to individual type traits for muscularity and udder of 32,275 first-parity ARP cows, obtaining 3 factor scores for individual muscularity (F1), udder side (F2), and udder conformation (F3). Data from 169,008 test-day records of milk, fat, and protein yield (kg), belonging to the first 3 lactations of 16,605 cows, were also analyzed. After obtaining genetic parameters for both morphological factors and milk production traits through a series of AIREML single-trait models, bivariate analyses were performed on a data set accounting for 201,283 records of 35,530 cows, to assess the phenotypic and genetic correlations among all factor scores and milk yield traits. The heritability estimates obtained proved to be moderate for both groups of traits, ranging from 0.132 (fat) to 0.314 (F1). Muscularity factor showed moderate and negative genetic correlations (ra) with udder size (-0.376) and udder conformation (0.214) factors. A low and negative ra was found between udder factors. Strong and positive ra were found among all the 3 milk production traits and F 0010 (ra≥0.597). Negative ra with milk traits were obtained for both F 0005 and F3, ranging from -0.417 to -0.221. Phenotypic correlations were lower than the genetic ones, and sometimes close to zero. The antagonism between milk production and meat attitude traits suggests that great attention should be paid in assigning proper weight to the traits, comprising functional traits such as udder conformation, included in selection indices for the dual-purpose breed. The ra obtained for factor scores are consistent with previous estimates for the corresponding individual type traits, and this confirms the possible use of factor analysis to

  18. Detrital zircon analysis from the Neoproterozoic-Cambrian sedimentary cover (Cuyania terrane), Sierra de Pie de Palo, Argentina: Evidence of a rift and passive margin system?

    NASA Astrophysics Data System (ADS)

    Naipauer, M.; Vujovich, G. I.; Cingolani, C. A.; McClelland, W. C.

    2010-03-01

    Metamorphic basement and its Neoproterozoic to Cambrian cover exposed in the Sierra de Pie de Palo, a basement block of the Sierras Pampeanas in Argentina, lie within the Cuyania terrane. Detrital zircon analysis of the cover sequence which includes, in ascending order, the El Quemado, La Paz, El Desecho, and Angacos Formations of the Caucete Group indicate a Laurentian origin for the Cuyania terrane. The lower section represented by the El Quemado and La Paz Formations is interpreted as having an igneous source related to a rift setting similar to that envisioned for the southern and eastern margins of Laurentia at approximately 550 Ma. The younger strata of the El Desecho Formation are correlative with the Cerro Totora Formation of the Precordillera, and both are products of rift sedimentation. Finally, the Angacos Formation and the correlative La Laja Formation of the Precordillera were deposited on the passive margin developed on the Cuyania terrane. The maximum depositional ages for the Caucete Group include ca. 550 Ma for the El Quemado Formation and ca. 531 Ma for the El Desecho Formation. Four different sediment sources areas were interpreted in the provenance analysis. The main source is crystalline basement dominated by early Mesoproterozoic igneous rocks related to the Granite-Rhyolite province of central and eastern Laurentia. Possible source areas for 1600 Ma metamorphic detrital zircons of the Caucete Group include the Yavapai-Mazatzal province ( ca. 1800-1600 Ma) of south-central to southwestern Laurentia. Younger Mesoproterozoic zircon is likely derived from Grenville-age medium- to high-grade metamorphic rocks and subordinate igneous rocks that form the basement of Cuyania as well as the southern Grenville province of Laurentia itself. Finally, Neoproterozoic igneous zircon in the Caucete Group records different magmatic pulses along the southern Laurentian margin during opening of Iapetus and break-up of Rodinia. Northwestern Cuyania terrane

  19. Segmentation: Slicing the Urban Pie.

    ERIC Educational Resources Information Center

    Keim, William A.

    1981-01-01

    Explains market segmentation and defines undifferentiated, concentrated, and differentiated marketing strategies. Describes in detail the marketing planning process at the Metropolitan Community Colleges. Focuses on the development and implementation of an ongoing recruitment program designed for the market segment composed of business employees.…

  20. Instant Pudding and Pie Filling

    DTIC Science & Technology

    1980-04-01

    0.57 Cocoa 12.46 Chocolate flavor enhancer 0.04 Artificial vanilla flavor 0.10 4 Food starch-modified, pre-gelatinized 14.32 Powdered vegetable... chocolate , vanilla and butterscotch flavors - were developed by NARADCOM, successfully production-tested, and subsequently procured through...powder of Example 1. These were chilled, sliced and served in the same manner as in Example 1. 8 Example 3 A chocolate flavored instant dessert

  1. SDI - pie in the sky

    SciTech Connect

    Arkin, W.M.

    1984-04-01

    Proponents of the controversial Strategic Defense Initiatives (SDI)reverse arrowfeel that the will to succeed will be as significant a factor as capability in their effort to make defense a popular concept. They reject the idea that a defensive system must be perfect, and want to loosen the hold of the Anti-Ballistic Missile (ABM) Treaty and Salt II. More than an improvement to deterrence, the goal of SDI is to make a technological leap over the Soviet Union to make its military investments obsolete. Scientists find research on defensive weapons more rewarding than work on offensive systems. Critics need to understand that the force of SDI is ideological in that it rejects the concept of mutually assured destruction (MAD) and concedes that nuclear war is possible.

  2. Validation environment for AIPS/ALS: Implementation and results

    NASA Technical Reports Server (NTRS)

    Segall, Zary; Siewiorek, Daniel; Caplan, Eddie; Chung, Alan; Czeck, Edward; Vrsalovic, Dalibor

    1990-01-01

    The work is presented which was performed in porting the Fault Injection-based Automated Testing (FIAT) and Programming and Instrumentation Environments (PIE) validation tools, to the Advanced Information Processing System (AIPS) in the context of the Ada Language System (ALS) application, as well as an initial fault free validation of the available AIPS system. The PIE components implemented on AIPS provide the monitoring mechanisms required for validation. These mechanisms represent a substantial portion of the FIAT system. Moreover, these are required for the implementation of the FIAT environment on AIPS. Using these components, an initial fault free validation of the AIPS system was performed. The implementation is described of the FIAT/PIE system, configured for fault free validation of the AIPS fault tolerant computer system. The PIE components were modified to support the Ada language. A special purpose AIPS/Ada runtime monitoring and data collection was implemented. A number of initial Ada programs running on the PIE/AIPS system were implemented. The instrumentation of the Ada programs was accomplished automatically inside the PIE programming environment. PIE's on-line graphical views show vividly and accurately the performance characteristics of Ada programs, AIPS kernel and the application's interaction with the AIPS kernel. The data collection mechanisms were written in a high level language, Ada, and provide a high degree of flexibility for implementation under various system conditions.

  3. Quels agents incriminés dans les mycoses du pied ? Enquête auprès des diabétiques consultant au CHU Mohammed VI de Marrakech

    PubMed Central

    Chegour, Hakima; El Ansari, Nawal; El Mghari, Ghizlane; Tali, Abdelali; Zoughaghi, Laila; Sebbani, Majda; Amine, Mohamed

    2014-01-01

    Les infections mycosiques du pied constituent un motif fréquent de consultation chez les diabétiques, le diabète constituant à la fois un facteur favorisant et aggravant les lésions cutanéomuqueuses. L'objectif de ce travail était d'identifier la flore mycologique locale responsable des lésions du pied chez le diabétique et déterminer les facteurs favorisant la survenue de mycoses. Il s'agissait d'une étude transversale intéressant des diabétiques suivis en consultation; un prélèvement mycologique, avec examen direct et culture, a été réalisé devant toute suspicion clinique de lésion mycosique. Quatre-vingt-deux patients ont été inclus. L'hémoglobine glycosylée moyenne a été de9,2% ± 2,23. Un intertrigo inter orteil a été noté dans 90,2% des cas; l'examen mycologique était positif dans 64,8% des cas, avec 18 cas de Trichophyton rubrum et 11 cas de Candida albicans. Une atteinte unguéale a été suspectée chez 65,9% patients; la culture a mis en évidence un Trichosporon pathogène chez sept patients, un Candida albicansdans six cas, un Trichophyton rubrum dans quatre cas, avec trois cas de Trichophyton mentagrophytes et deux cas de Scytalidium dimidiatum. L’étude analytique, après confirmation mycologique, en fonction des principales caractéristiques des patients a montré que l'atteinte mycosique du pied est significativement corrélée au déséquilibre glycémique. Ce travail a montré la prédominance du Trichophyton rubrum dans les lésions d'intertrigo inter orteil et du Trichosporon dans les onychomycoses, avec une prédominance globale plus globale plus élevée du TR. PMID:25170372

  4. MOX LTA Fuel Cycle Analyses: Nuclear and Radiation Safety

    SciTech Connect

    Pavlovitchev, A.M.

    2001-09-28

    Tasks of nuclear safety assurance for storage and transport of fresh mixed uranium-plutonium fuel of the VVER-1000 reactor are considered in the view of 3 MOX LTAs introduction into the core. The precise code MCU that realizes the Monte Carlo method is used for calculations.

  5. Apport de l’écho-doppler artériel des membres inférieurs dans la prise en charge du pied diabétique à l'hôpital Saint-Jean de Dieu de Thiès (Sénégal)

    PubMed Central

    Dia, Aliou Amadou; Affangla, Désiré Alain; Dione, Jean-Michel; Akpo, Géraud; Mbengue, Marie; Ka, Mamadou Mourtalla; Diop, Bernard Marcel

    2015-01-01

    Introduction Le pied diabétique se définit comme l'ensemble des manifestations trophiques du pied survenant chez le diabétique par atteinte nerveuse, artérielle et ou infectieuse. Le pied diabétique est un problème majeur de santé publique à l’échelle mondiale avec un taux d'amputation de membres inférieurs très élevé. L’écho-doppler artériel des membres inférieurs est de nos jours incontournable dans la prise en charge du pied diabétique. Le but de cette étude est de montrer la place prépondérante qu'occupe l’écho-doppler artériel dans le bilan lésionnel du pied diabétique. Méthodes Nous avons mené une étude rétrospective monocentrique incluant 46 patients sur une période de 24 mois, de mars 2012 à mars 2014 à l'hôpital Saint-Jean de Dieu, un des deux hôpitaux de référence de la région de Thiès, doté depuis juillet 2011 d'un centre moderne de traitement du diabète et des maladies cardio-métaboliques (Diabcarmet). Dans les critères d'inclusion, nous avons sélectionné tous les patients diabétiques adressés pour un écho-doppler artériel des membres inférieurs dans le cadre d'une prise en charge du pied diabétique. Etaient exclus de l’étude, les patients artéritiques non-diabétiques et les patients diabétiques asymptomatiques référés pour un bilan écho-doppler de routine. Résultats Le sex-ratio était de 1.42 (27 hommes pour 19 femmes). L’âge moyen des patients était de 62,86 ans avec des extrêmes de 23 et 88 ans. 60% des patients (n=28) étaient âgés entre 50 et 70 ans. Le diabète de type 2 était retrouvé chez 95% des patients (n=44) alors que le diabète de type 1 représentait 5% (n=2). La moyenne d’évolution du diabète était estimée à 8 ans, avec des extrêmes de 2 et 20 ans. On notait une atteinte du pied droit chez 24 patients, une atteinte du pied gauche chez 18 patients et une atteinte bilatérale chez 4 patients. La plupart du temps, les lésions du pied diabétique survenaient

  6. Late results.

    PubMed

    Daly, B D

    1999-08-01

    Pneumonectomy is performed for a number of benign and malignant conditions. It is most commonly performed for lung cancer. Adjuvant and neoadjuvant protocols have increased the number of these operations being performed and the long-term results are improving. Pneumonectomy may also be performed for metastases to lung and for mesothelioma with encouraging results. Some bronchial adenomas require pneumonectomy. Treatment of resistant mycobacteria or the complications of tuberculosis frequently require pneumonectomy. Late bronchopleural fistulae, esophagopleural fistulae, and empyema may occur.

  7. Research Results

    NASA Astrophysics Data System (ADS)

    2011-12-01

    Research on Global Carbon Emission and Sequestration NSFC Funded Project Made Significant Progress in Quantum Dynamics Functional Human Blood Protein Obtained from Rice How Giant Pandas Thrive on a Bamboo Diet New Evidence of Interpersonal Violence from 129,000 Years Ago Found in China Aptamer-Mediated Efficient Capture and Release of T Lymphocytes on Nanostructured Surfaces BGI Study Results on Resequencing 50 Accessions of Rice Cast New Light on Molecular Breeding BGI Reports Study Results on Frequent Mutation of Genes Encoding UMPP Components in Kidney Cancer Research on Habitat Shift Promoting Species Diversification

  8. Results of postirradiation examination of the in-pile blockage experiments MOL-7C/4 and MOL-7C/5

    SciTech Connect

    Weimar, P.; Schleisiek, K. )

    1991-10-01

    The Mol-7C in-pile local blockage experiments are performed in the BR-2 reactor at Mol, Belgium as a joint project of Kernforchungszentrum Karlsruhe (KfK) and Studiecentrum voor Kernenergie/Centre d'Etude de l'Energie Nuclearire-Mol. The main objective is to investigate the consequences of local cooling disturbances in liquid-metal-cooled reactor (LMR) fuel subassemblies. In the tests Mol-7C/4 and MOL-7C/5, fuel pins from KNK II are used with a burnup of 5 and 1.7%, respectively. An active central porous blockage is used to simulate the cooling disturbance. During irradiation, the blockage causes significant local damage, including melting of cladding and fuel. Extensive postirradiation examinations (PIE) are performed to investigate the extent of damage. In this paper a description and interpretation of results of the destructive PIE performed at the Hot Cells Laboratory at KfK is given, along with some conclusions related to LMR safety.

  9. The Cell Wall Polymer Lipoteichoic Acid Becomes Nonessential in Staphylococcus aureus Cells Lacking the ClpX Chaperone

    PubMed Central

    Bowman, Lisa; Millership, Charlotte; Dupont Søgaard, Mia; Kaever, Volkhard; Siljamäki, Pia; Savijoki, Kirsi; Varmanen, Pekka; Nyman, Tuula A.

    2016-01-01

    ABSTRACT Lipoteichoic acid (LTA) is an important cell wall component of Gram-positive bacteria and a promising target for the development of vaccines and antimicrobial compounds against Staphylococcus aureus. Here we demonstrate that mutations in the conditionally essential ltaS (LTA synthase) gene arise spontaneously in an S. aureus mutant lacking the ClpX chaperone. A wide variety of ltaS mutations were selected, and among these, a substantial portion resulted in premature stop codons and other changes predicted to abolish LtaS synthesis. Consistent with this assumption, the clpX ltaS double mutants did not produce LTA, and genetic analyses confirmed that LTA becomes nonessential in the absence of the ClpX chaperone. In fact, inactivation of ltaS alleviated the severe growth defect conferred by the clpX deletion. Microscopic analyses showed that the absence of ClpX partly alleviates the septum placement defects of an LTA-depleted strain, while other phenotypes typical of LTA-negative S. aureus mutants, including increased cell size and decreased autolytic activity, are retained. In conclusion, our results indicate that LTA has an essential role in septum placement that can be bypassed by inactivating the ClpX chaperone. PMID:27507828

  10. Discrimination of Beef Samples by Electronic Nose and Pattern Recognition Techniques Preliminary Results

    NASA Astrophysics Data System (ADS)

    Cornale, P.; Barbera, S.

    2009-05-01

    In this paper a study about the possibility of beef characterization with electronic nose is presented. Three beef classes were compared: Piemontese (PIE), Limousin (FRA) and meat from Argentine (ARG). 150 meat samples were put in glass vials and analysed with a commercial electronic nose instrument based on 10 metal oxide semiconductor sensors. Sensors response of beef classes seemed to be different. Different supervised and unsupervised pattern recognition procedures were applied to sensors signal: principal component analysis (PCA) and partial least square discriminant analysis (PLS-DA). Multivariate analysis pointed out promising classification and prediction results. Three clusters (according to the beef classes) can be clearly discriminated in PCA score plot. Statistical parameters from calibration, validation and prediction of PLS-DA model revealed themselves to be indices of a good model. These results demonstrate that electronic nose technology with multivariate analysis models is promising for the rapid determination of differences in meat aroma.

  11. Tevatron results

    SciTech Connect

    Lefevre, R.; /Barcelona, Autonoma U.

    2005-01-01

    Recent results obtained by the CDF and D0 experiments at the Tevatron Run II are presented. A first part is dedicated to QCD physics where inclusive jet production, dijet azimuthal decorrelations and jet shapes measurements are reported. Electroweak physics is then discussed relating measurements of the W and Z bosons productions, of the forward-backward charge asymmetry in W production, of the W width and of the top quarks mass. The extensive Run II exploration program is finally approached reporting about searches for neutral supersymmetric Higgs bosons in multijet events and for sbottom quark from gluino decays.

  12. [Features of the distribution of BoLA-A antigens and alleles of the BoLA-DRB3 gene in Black Pied cattle in relation to association with leukemia].

    PubMed

    Ernst, L K; Sulimova, G E; Orlova, A R; Udina, I G; Pavlenko, S P

    1997-01-01

    The character of distribution of BoLA class-I antigens was studied in Black Pied cattle populations differing in status in relation to leukemia. Associative relationships of distinct antigens with resistance and susceptibility to leukemia were revealed. Using the statusmetria method, an integral estimate of predisposition to leukemia (Z) was calculated taking into consideration the contribution of each antigen in the immunogenetic status of the animal. The interval of Z values was determined, which allowed animals to be divided into groups according to resistance or susceptibility to leukemia. Alleles of the BoLA-DRB3 gene were typed in subsamples of animals with leukemia and healthy animals by the PCR-RFLP method. Twenty alleles of the gene were detected, and their frequencies were determined in both subsamples. Alleles mediating resistance of animals to leukemia (BoLA-DRB3.2*11, *23, and *28) were distributed in the group of healthy animals with frequencies of 0.079, 0.132, and 0.053, respectively; they were completely absent in animals with leukemia. The data on the estimate of animal status in relation to leukemia, which were obtained by the method of statusmetria taking in consideration the real contribution of the each class-I antigen in the detection of the disease risk (value Z), and data of allele typing by the PCR-RFLP method were shown to be in good agreement. The possibility of using BoLA class-I antigen typing in herds to determine the number of animals with leukemia was demonstrated.

  13. Crustal shortening, exhumation, and strain localization in a collisional orogen: The Bajo Pequeño Shear Zone, Sierra de Pie de Palo, Argentina

    NASA Astrophysics Data System (ADS)

    Garber, Joshua M.; Roeske, Sarah M.; Warren, Jessica; Mulcahy, Sean R.; McClelland, William C.; Austin, Lauren J.; Renne, Paul R.; Vujovich, Graciela I.

    2014-07-01

    The Bajo Pequeño Shear Zone (BPSZ) is a lower-crustal shear zone that records shortening and exhumation associated with the establishment of a new plate boundary, and its placement in a regional structural context suggests that local- to regional-scale strain localization occurred with progressive deformation. A kilometer-scale field and analytical cross section through the ~80 m thick BPSZ and its adjacent rocks indicates an early Devonian (405-400 Ma) phase of deformation on the western margin of Gondwanan continental crust. The earliest stages of the BPSZ, recorded by metamorphic and microstructural data, involved thrusting of a hotter orthogneiss over a relatively cool pelitic unit, which resulted in footwall garnet growth and reset footwall white mica 40Ar/39Ar ages in proximity to the shear zone. Later stages of BPSZ activity, as recorded by additional microstructures and quartz c-axis opening angles, were characterized by strain localization to the center of the shear zone coincident with cooling and exhumation. These and other data suggest that significant regional tectonism persisted in the Famatinian orogenic system for 60-70 million years after one microplate collision (the Precordillera) but ceased 5-10 million years prior to another (Chilenia). A survey of other synchronous structures shows that strain was accommodated on progressively narrower structures with time, indicating a regional pattern of strain localization and broad thermal relaxation as the Precordillera collision evolved.

  14. PIE: A Dynamic Failure-Based Technique

    NASA Technical Reports Server (NTRS)

    Voas, Jeffrey M.

    1990-01-01

    This paper presents a dynamic technique for statistically estimating three program characteristics that affect a program's computational behavior: (1) the probability that a particular section of a program is executed, (2) the probability that the particular section affects the data state, and (3) the probability that a data state produced by that section has an effect on program output. These three characteristics can be used to predict whether faults are likely to be uncovered by software testing. Index Terms: Software testing, data state, fault, failure, testability. 1 Introduction

  15. A pie in the face of greed.

    PubMed

    Baldwin, F D

    1994-01-01

    Though every physician has his or her own way of treating patients, Hunter D. "Patch" Adams, MD, has an approach all his own: He uses clowning to break the barriers of practicing medicine. In a recent Central Pennsylvania appearance, Dr. Adams discussed his approach, as well as the importance of compassion in medicine.

  16. Trash Pie: Is Your School Serving?

    ERIC Educational Resources Information Center

    Hoover, Krista M.; Curran, Mary Carla

    2010-01-01

    In observation of Earth Day, third-grade students were invited to examine what they contribute to the landfill and learn new ways they could help protect the environment. In this lesson, students collected, evaluated, and displayed data comparing the trash generated by home-lunch versus school-lunch students. Students interpreted their findings…

  17. Of stewardship, motherhood and apple pie.

    PubMed

    Livermore, David M

    2014-04-01

    Antibiotic stewardship is universally agreed to be desirable, but optimal models for stewardship remain uncertain. UK stewardship targets the particular antibiotic families-cephalosporins and fluoroquinolones-blamed for the selection of Clostridium-difficile-associated disease. To balance this there have been dramatic increases in the use of penicillin-β-lactamase inhibitor combinations. By channelling selection pressure in this way, we hazard destroying the utility of these antibiotic classes in turn, as happened with gonorrhoea where penicillins, fluoroquinolones and cefixime were sequentially lost as therapies. Strikingly, in context, almost all carbapenemase-producers are highly resistant to penicillin-β-lactamase inhibitor combinations, which may select for them. There is an urgent need to explore an alternative stewardship model, seeking to limit total antibiotic use but to maintain heterogeneity in what is used, avoiding concentrated selection pressure. There is also a great need to improve and accelerate diagnostics for infection and resistance, reducing or removing the need for protracted empirical treatment with broad-spectrum agents.

  18. Interaction of inflammatory and anti-inflammatory responses in microglia by Staphylococcus aureus-derived lipoteichoic acid

    SciTech Connect

    Huang, Bor-Ren; Tsai, Cheng-Fang; Lin, Hsiao-Yun; Tseng, Wen-Pei; Huang, Shiang-Suo; Wu, Chi-Rei; Lin, Chingju; Yeh, Wei-Lan; Lu, Dah-Yuu

    2013-05-15

    We investigated the interaction between proinflammatory and inflammatory responses caused by Staphylococcus aureus-derived lipoteichoic acid (LTA) in primary cultured microglial cells and BV-2 microglia. LTA induced inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein levels increase in a concentration- and time-dependent manner. Meanwhile, LTA also increased nitric oxide (NO) and PGE{sub 2} production in microglia. Administration of TLR2 antagonist effectively inhibited LTA-induced NO, iNOS, and COX-2 expression. Moreover, treatment of cells with LTA caused a time-dependent activation of ERK, p38, JNK, as well as AKT. We also found that LTA-induced iNOS and COX-2 up-regulation were attenuated by p38, JNK, and PI3-kinase inhibitors. On the other hand, LTA-enhanced HO-1 expression was attenuated by p38 and PI3-kinase inhibitors. Treatment of cells with NF-κB and AP-1 inhibitors antagonized LTA-induced iNOS and COX-2 expression. However, only NF-κB inhibitors reduced LTA-induced HO-1 expression in microglia. Furthermore, stimulation of cells with LTA also activated IκBα phosphorylation, p65 phosphorylation at Ser{sup 536}, and c-Jun phosphorylation. Moreover, LTA-induced increases of κB-DNA and AP-1-DNA binding activity were inhibited by p38, JNK, and PI3-kinase inhibitors. HO-1 activator CoPP IX dramatically reversed LTA-induced iNOS expression. Our results provided mechanisms linking LTA and inflammation/anti-inflammation, and indicated that LTA plays a regulatory role in microglia activation. - Highlights: • LTA causes an increase in iNOS, COX-2, and HO-1 expression in microglia. • LTA induces iNOS and COX-2 expression through TLR-2/NF-κB and AP-1 pathways. • HO-1 expression is regulated through p38, JNK, PI3K/AKT and AP-1 pathways. • Induced HO-1 reduces LTA-induced iNOS expression. • LTA plays a regulatory role on inflammatory/anti-inflammatory responses.

  19. Lipoteichoic acid promotes nuclear accumulation of β-catenin via AKT in human gingival fibroblasts.

    PubMed

    Gutiérrez-Venegas, Gloria; Cardoso-Jiménez, Patricia

    2011-09-01

    Treatment of human gingival fibroblasts (HGFs) with lipoteichoic acid (LTA) results in the activation of multiple signaling pathways. Exposure of HGF to LTA has been shown to result in the activation of phosphatidylinositol 3-kinase (PI3K). The aim of this study was to evaluate the effects of LTA-induced PI3K activation in HGFs. We found that LTA treatment results in the phosphorylation of AKT and glycogen synthase kinase (GSK-3). Inactivation of GSK-3 promotes the nuclear accumulation of β-catenin and expression of connexin43. Treatment with PI3K inhibitors, wortmannin and LY294002, inhibited LTA-induced phosphorylation of AKT and GSK-3, demonstrating that these events require PI3K activation. This report is the first demonstration that LTA treatment activates AKT in HGFs.

  20. In-pile test results of U-silicide or U-nitride coated U-7Mo particle dispersion fuel in Al

    NASA Astrophysics Data System (ADS)

    Kim, Yeon Soo; Park, J. M.; Lee, K. H.; Yoo, B. O.; Ryu, H. J.; Ye, B.

    2014-11-01

    U-silicide or U-nitride coated U-Mo particle dispersion fuel in Al (U-Mo/Al) was in-pile tested to examine the effectiveness of the coating as a diffusion barrier between the U-7Mo fuel kernels and Al matrix. This paper reports the PIE data and analyses focusing on the effectiveness of the coating in terms of interaction layer (IL) growth and general fuel performance. The U-silicide coating showed considerable success, but it also provided evidence for additional improvement for coating process. The U-nitride coated specimen showed largely inefficient results in reducing IL growth. From the test, important observations were also made that can be utilized to improve U-Mo/Al fuel performance. The heating process for coating turned out to be beneficial to suppress fuel swelling. The use of larger fuel particles confirmed favorable effects on fuel performance.

  1. Fuel and fission product behaviour in early phases of a severe accident. Part I: Experimental results of the PHEBUS FPT2 test

    NASA Astrophysics Data System (ADS)

    Barrachin, M.; Gavillet, D.; Dubourg, R.; De Bremaecker, A.

    2014-10-01

    One objective of the FPT2 test of the PHEBUS FP Program was to study the degradation of an irradiated UO2 fuel test section and the fission product behaviour under conditions of low steam flow. The results of the post-irradiation examinations (PIE) at the upper levels (823 and 900 mm) of the 1-m long test section are presented in this paper. Material interactions leading to local corium formation were identified: firstly between fuel and Zircaloy-4 cladding, notably at 823 mm, where the cladding melting temperature was reached, and secondly between fuel and stainless steel oxides. Regarding fission products, molybdenum left so-called metallic precipitates mainly composed of ruthenium. Xenon and caesium behave similarly whereas barium and molybdenum often seems to be associated in precipitates.

  2. Seasonal migration to high latitudes results in major reproductive benefits in an insect

    PubMed Central

    Chapman, Jason W.; Bell, James R.; Burgin, Laura E.; Reynolds, Donald R.; Pettersson, Lars B.; Hill, Jane K.; Bonsall, Michael B.; Thomas, Jeremy A.

    2012-01-01

    Little is known of the population dynamics of long-range insect migrants, and it has been suggested that the annual journeys of billions of nonhardy insects to exploit temperate zones during summer represent a sink from which future generations seldom return (the “Pied Piper” effect). We combine data from entomological radars and ground-based light traps to show that annual migrations are highly adaptive in the noctuid moth Autographa gamma (silver Y), a major agricultural pest. We estimate that 10–240 million immigrants reach the United Kingdom each spring, but that summer breeding results in a fourfold increase in the abundance of the subsequent generation of adults, all of which emigrate southward in the fall. Trajectory simulations show that 80% of emigrants will reach regions suitable for winter breeding in the Mediterranean Basin, for which our population dynamics model predicts a winter carrying capacity only 20% of that of northern Europe during the summer. We conclude not only that poleward insect migrations in spring result in major population increases, but also that the persistence of such species is dependent on summer breeding in high-latitude regions, which requires a fundamental change in our understanding of insect migration. PMID:22927392

  3. Leukotriene A4 modulates generation of leukotriene B4 and sulphidopeptide leukotrienes by human neutrophils.

    PubMed Central

    Hilger, R A; König, W

    1992-01-01

    We investigated the influence of exogenous leukotriene A4 (LTA4) on the reactivity of polymorphonuclear leucocytes (PMN). PMN were either prestimulated with LTA4 or incubated simultaneously with LTA4 and the Ca ionophore A23187 or sodium fluoride (NaF). The Ca ionophore A23187 and NaF induced generation of LTB4 from PMN was significantly diminished in the presence of LTA4 while the formation of LTC4 was enhanced. In contrast, preincubation of cells with LTA4 followed by subsequent stimulation with NaF synergistically increased the LTB4 generation from PMN. LTA4, either alone or in combination with the calcium ionophore A23187 or NaF, decreases GTPase activity in human PMN. This decrease was abolished when LTA4 pretreated cells were subsequently stimulated with NaF, but not with calcium ionophore A23187, suggesting a regulatory role of LTA4 on G-proteins. The results demonstrate dual functions of LTA4: it serves as a substrate for the generation of leukotrienes and also regulates the susceptibility of human PMN for subsequent response. PMID:1335961

  4. Cholesterol testing and results

    MedlinePlus

    Cholesterol test results; LDL test results; VLDL test results; HDL test results; Coronary risk profile results; Hyperlipidemia- ... Some cholesterol is considered good and some is considered bad. Different blood tests can be done to measure each ...

  5. Your Kidney Test Results

    MedlinePlus

    ... blood vessels healthy. Vitamin D is important for bones and heart health. 1 Your Kidney Test Results Other Important Tests, continued A1C (for patients with diabetes) Results Goal: Your Result: Total Cholesterol Normal: Less ...

  6. Comparison of silver, cesium, and strontium release predictions using PARFUME with results from the AGR-1 irradiation experiment

    NASA Astrophysics Data System (ADS)

    Collin, Blaise P.; Petti, David A.; Demkowicz, Paul A.; Maki, John T.

    2015-11-01

    The PARFUME (PARticle FUel ModEl) code was used to predict the release of fission products silver, cesium, and strontium from tristructural isotropic coated fuel particles and compacts during the first irradiation experiment (AGR-1) of the Advanced Gas Reactor Fuel Development and Qualification program. The PARFUME model for the AGR-1 experiment used the fuel compact volume average temperature for each of the 620 days of irradiation to calculate the release of silver, cesium, and strontium from a representative particle for a select number of AGR-1 compacts. Post-irradiation examination (PIE) measurements provided data on release of these fission products from fuel compacts and fuel particles, and retention of silver in the compacts outside of the silicon carbide (SiC) layer. PARFUME-predicted fractional release of silver, cesium, and strontium was determined and compared to the PIE measurements. For silver, comparisons show a trend of over-prediction at low burnup and under-prediction at high burnup. PARFUME has limitations in the modeling of the temporal and spatial distributions of the temperature and burnup across the compacts, which affects the accuracy of its predictions. Nevertheless, the comparisons on silver release lie in the same order of magnitude. Results show an overall over-prediction of the fractional release of cesium by PARFUME. For particles with failed SiC layers, the over-prediction is by a factor of up to 3, corresponding to a potential over-estimation of the diffusivity in uranium oxycarbide (UCO) by a factor of up to 250. For intact particles, whose release is much lower, the over-prediction is by a factor of up to 100, which could be attributed to an over-estimated diffusivity in SiC by about 40% on average. The release of strontium from intact particles is also over-predicted by PARFUME, which also points towards an over-estimated diffusivity of strontium in either SiC or UCO, or possibly both. The measured strontium fractional release

  7. Product formation controlled by substrate dynamics in leukotriene A4 hydrolase.

    PubMed

    Stsiapanava, Alena; Tholander, Fredrik; Kumar, Ramakrishnan B; Qureshi, Abdul Aziz; Niegowski, Damian; Hasan, Mahmudul; Thunnissen, Marjolein; Haeggström, Jesper Z; Rinaldo-Matthis, Agnes

    2014-02-01

    Leukotriene A4 hydrolase/aminopeptidase (LTA4H) (EC 3.3.2.6) is a bifunctional zinc metalloenzyme with both an epoxide hydrolase and an aminopeptidase activity. LTA4H from the African claw toad, Xenopus laevis (xlLTA4H) has been shown to, unlike the human enzyme, convert LTA4 to two enzymatic metabolites, LTB4 and another biologically active product Δ(6)-trans-Δ(8)-cis-LTB4 (5(S),12R-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoic acid). In order to study the molecular aspect of the formation of this product we have characterized the structure and function of xlLTA4H. We solved the structure of xlLTA4H to a resolution of 2.3Å. It is a dimeric structure where each monomer has three domains with the active site in between the domains, similar as to the human structure. An important difference between the human and amphibian enzyme is the phenylalanine to tyrosine exchange at position 375. Our studies show that mutating F375 in xlLTA4H to tyrosine abolishes the formation of the LTB4 isomeric product Δ(6)-trans-Δ(8)-cis-LTB4. In an attempt to understand how one amino acid exchange leads to a new product profile as seen in the xlLTA4H, we performed a conformer analysis of the triene part of the substrate LTA4. Our results show that the Boltzmann distribution of substrate conformers correlates with the observed distribution of products. We suggest that the observed difference in product profile between the human and the xlLTA4H arises from different level of discrimination between substrate LTA4 conformers.

  8. Lipoteichoic acid enhances IL-6 production in human synovial fibroblasts via TLR2 receptor, PKCdelta and c-Src dependent pathways.

    PubMed

    Tang, Chih-Hsin; Hsu, Chin-Jung; Yang, Wei-Hung; Fong, Yi-Chin

    2010-06-01

    Patients with rheumatoid arthritis (RA) are at increased risk of developing infections and appear to be particularly susceptible to septic arthritis. Lipoteichoic acid (LTA), a cell wall component of Gram-positive bacteria is an amphiphilic, negatively charged glycolipid. However, the effects of LTA on human synovial fibroblasts are largely unknown. We investigated the signaling pathway involved in IL-6 production stimulated by LTA in rheumatoid arthritis synovial fibroblasts (RASF). LTA caused concentration- and time-dependent increases in IL-6 production. LTA-mediated IL-6 production was attenuated by Toll-like receptor 2 (TLR2) monoclonal antibody or siRNA. Pretreatment with PKCdelta inhibitor (rottlerin), c-Src inhibitor (PP2), AP-1 inhibitor (tanshinone IIA) and NF-kappaB inhibitor (PDTC and TPCK) also inhibited the potentiating action of LTA. However, focal adhesion kinase (FAK) mutant and siRNA did not affect LTA-mediated IL-6 production. Stimulation of cells with LTA increased the PKCdelta and c-Src phosphorylation and kinase activity. LTA increased the accumulation of p-c-Jun and p-p65 in the nucleus, as well as AP-1 and NF-kappaB luciferase activity. LTA-mediated increase of AP-1 and NF-kappaB luciferase activity was inhibited by rottlerin and PP2 or TLR2 and PKCdelta siRNA or c-Src mutant. Our results suggest that LTA-increased IL-6 production in human synovial fibroblasts via the TLR2 receptor, PKCdelta, c-Src, AP-1 and NF-kappaB signaling pathways.

  9. A practical concept for powered or tethered weight-lifting LTA vehicles

    NASA Technical Reports Server (NTRS)

    Balleyguier, M. A.

    1975-01-01

    A concept for a multi-hull weightlifting airship is presented. The concept is based upon experience in the design and handling of gas-filled balloons for commercial purposes, it was first tested in April, 1972. In the flight test, two barrage balloons were joined side-by-side, with an intermediate frame, and launched in captive flight. The success of this flight test led to plans for a development program calling for a powered, piloted prototype, a follow-on 40 ton model, and a 400 ton transport model. All of these airships utilize a tetrehedric three-line tethering method for loading and unloading phases of flight, which bypasses many of the difficulties inherent in the handling of a conventional airship near the ground. Both initial and operating costs per ton of lift capability are significantly less for the subject design than for either helicopters or airships of conventional mono-hull design.

  10. The technology assessment of LTA aircraft systems. [hybrid airships for passenger and cargo transportation

    NASA Technical Reports Server (NTRS)

    1976-01-01

    The advantages of conventional small and large airships over heavier than air aircraft are reviewed and the need for developing hybrid aircraft for passenger and heavy charge transport is assessed. Performance requirements and estimated operating costs are discussed for rota-ships to be used for short distance transportation near large cities as well as for airlifting civil engineering machinery and supplies for the construction of power stations, dams, tunnels, and roads in remote areas or on isolated islands.

  11. Feasibility Study of Endo- and Exo-skeletal Framed Structures with Envelopes for LTA Platforms

    DTIC Science & Technology

    2011-02-15

    W911NF- 10 -1-0020 622618 Form Approved OMB NO. 0704-0188 56760-EG-II.1 11. SPONSOR/MONITOR’S REPORT NUMBER(S) 10 . SPONSOR/MONITOR’S ACRONYM(S) ARO...Grant #: W911NF- 10 -1-0020 Short Term Innovative Research To Col. Young Reed, Program Manager Army Research Office Research Triangle...13.74 0.0408 0.254 0.081 0.068 0.067 0.065 Altitude, ft Air Density, lb/ft^3 Atm Pressure, in. Hg * * includes 10 % wt. of endoskeleton structure

  12. Autonomous Soaring Flight Results

    NASA Technical Reports Server (NTRS)

    Allen, Michael J.

    2006-01-01

    A viewgraph presentation on autonomous soaring flight results for Unmanned Aerial Vehicles (UAV)'s is shown. The topics include: 1) Background; 2) Thermal Soaring Flight Results; 3) Autonomous Dolphin Soaring; and 4) Future Plans.

  13. Recent results from CDF

    SciTech Connect

    Sally Carol Seidel

    2001-07-16

    During the past year, the CDF Experiment has reported on a variety of results concerning QCD and electroweak studies, studies of the top quark, and searches for new phenomena. A sample of these results is presented here.

  14. Getting Districtwide Results

    ERIC Educational Resources Information Center

    McBeath, Angus

    2006-01-01

    This monograph is based on a keynote presentation by Angus McBeath at the "Getting Districtwide Results" Conference in Long Beach, California, which was co-sponsored by the Cross City Campaign for Urban School Reform and Focus on Results. The author, a former superintendent of the Edmonton Public Schools, how his school district was…

  15. Recent results from TRISTAN

    SciTech Connect

    Enomoto, Ryoji

    1997-01-01

    TRISTAN results on {gamma}{gamma} physics from 1994 to 1995 are reviewed in this report. We have systematically investigated jet production, the {gamma}-structure function, and charm pair production in {gamma}{gamma} processes. The results are discussed, and future prospects are presented.

  16. Diffraction Results from CDF

    SciTech Connect

    Goulianos, Konstantin

    2012-04-01

    We present final results by the CDF II collaboration on diffractive W and Z production, report on the status of ongoing analyses on diffractive dijet production and on rapidity gaps between jets, and briefly summarize results obtained on exclusive production pointing to their relevance to calibrating theoretical models used to predict exclusive Higgs-boson production at the LHC.

  17. Outcomes of Living Donor Liver Transplantation Alone for Patients on Maintenance Renal Replacement Therapy in Japan

    PubMed Central

    Eguchi, Susumu; Furukawa, Hiroyuki; Uemoto, Shinji; Umeshita, Koji; Imamura, Hajime; Soyama, Akihiko; Shimamura, Tsuyoshi; Isaji, Shuji; Ogura, Yasuhiro; Egawa, Hiroto; Kawachi, Shigeyuki; Kasahara, Mureo; Nagano, Hiroaki; Ku, Yonson; Ohdan, Hideki; Maehara, Yoshihiko; Sato, Shuntaro; Inomata, Yukihiro

    2016-01-01

    Background Because simultaneous liver and kidney transplantation has been limited as a standard practice because of a severe shortage of deceased donors in Japan, living donor (LD) liver transplantation alone (LTA) is indicated in most recipients with maintenance renal replacement therapy (MRRT). Methods A retrospective nationwide survey of LD LTA was performed for liver transplant patients on MRRT. The characteristics of donors and recipients, postoperative complications, survival rate, and causes of death were analyzed. Results In the adult cases (n = 28), the overall survival rate at 1 year and 5 years were 66.1% and 57.3%, respectively. When compared with those adults without MRRT (n = 237), it was significantly worse. In the 7 pediatric cases, the overall survival rate at 1 and 5 years were both 83.3%. Three adult recipients died of nonaneurysm cerebral hemorrhage after 1 year and 1 adult recipient died of acute heart failure after 7 months. In adult recipients with MRRT, graft weight versus standard liver volume, and duration and blood loss in LTA surgery were associated with poor outcomes after LD LTA. Multivariate analysis revealed that MRRT was highest hazard ratio on patient survival after LD LTA. Conclusions Early post-LD LTA mortality was higher in patients with MRRT than in those without MRRT with characteristic causes. Smaller grafts for size and a complicated surgery were associated with poor outcome after LD LTA. Thus, LD LTA in adult patients on MRRT should be carefully treated with meticulous postoperative management and follow-up. PMID:27500264

  18. Unfavourable results in hypospadias

    PubMed Central

    Agrawal, Karoon; Misra, Anshumali

    2013-01-01

    Hypospadias urethroplasty is considered difficult as the complications and unfavourable results are not uncommon. At the turn of the century, due to a better understanding of applied anatomy of hypospadias, new techniques were developed which significantly brought down the complication rate. However unfavourable results are still disturbing. An algorithm for selection of surgery has been presented. Forty three secondary surgeries were performed over 3 years for correction of unfavourable results. The urethrocutaneous fistula was the most common (21%) followed by meatal stenosis (14%) and narrow neourethra (14%). Common unfavourable results have been discussed. On the basis of experience with a large number of hypospadias urethroplasty ‘tips to avoid or minimise unfavourable results’ have been presented. However, one should assess the final outcome of urethroplasty using hypospadias objective scoring evaluation. PMID:24501477

  19. Electroweak results from CDF

    SciTech Connect

    D. S. Waters

    2004-06-02

    Inclusive W and Z production cross-sections have been measured by CDF and certain electroweak parameters extracted with high precision from these measurements. New results on diboson production at the Tevatron are also presented.

  20. Results from MAC

    SciTech Connect

    Chadwick, G.B.

    1983-05-01

    The MAC detector has been exposed at PEP to 40 pb/sup -1/ luminosity of e/sup +/e/sup -/ collisions. The detector is described and recent results of a continuing analysis of hadronic cross section, lepton pair charge asymmetry, Bhabha process, two photon final state and radiative ..mu.. pairs are given. New results on flavor tagging of hadronic events with an inclusive ..mu.., and some searches for new particles are presented.

  1. Unfavorable results in replantation.

    PubMed

    Thomas, Abraham G

    2013-05-01

    Reattachment of amputated parts of the body (Replantation) has become a reality since the first arm replant was carried out six decades ago. Failures were not uncommon in the beginning, leading on to the analysis of the problem and refinements in technique. Improvements in sutures, instrumentation and better microscopes further helped the surgeons to do replantation with better finesse and functional results. Evaluation of results and particularly failure and long term results help the younger surgeons to learn from the difficulties faced earlier to do better in the future. An attempt is made to list various aspects of replantation experienced by the author during the past 30 years, particularly in reference to unfavorable results, which had been occasionally total failure, or a partial failure, with poor function and cosmesis due to infection. An insensate limb with poor function is the result of inadequate or improper nerve coaptation or infection destroying the whole repair. It is apt to mention that infection is mostly the result of poor vascularity due to devitalized tissue. Difficulties arise often in identifying the viable tissue, particularly while debriding in the distal amputated part since there is no bleeding. Experience counts in this, specifically to identify the viable muscle. The factors that may lead to complications are listed with remarks to avoid them.

  2. Recent results from CDF

    SciTech Connect

    Takikawa, K.; CDF

    1998-02-15

    We first present recent CDF results on the top quark, covering the measurement of the t{anti t} production cross section and the top quark mass, the observation of hadronic W decays in top events, the measurement of V{sub tb}, the search for flavor changing neutral current decays, and kinematical properties of t{anti t} production. Then we present one topic from CDF exotic physics results, i.e., the search for first-generation leptoquarks, and one topic from CDF B physics results, i.e., the measurement of time-dependent B{sup 0}-{anti B}{sup 0} mixing. Finally we conclude by briefly mentioning the prospects for Run II.

  3. Recent results from PEP

    SciTech Connect

    Hollebeek, R.

    1981-10-01

    Preliminary results are presented for the data taken by the MARK II and MAC collaborations at the PEP storage ring. Results include measurements of QED processes, limits on the weak couplings g/sub V/ and g/sub A/, limits on anomalous lepton production, the measurement of the tau lifetime, scale violation in inclusive hadron production, Monte Carlo independent tests of QCD using energy-energy correlations and single jet energy moments, measurements of the properties of three jet events, and measurements of proton, neutral kaon, lambda and proton pair yields.

  4. Continuous ACL graft, results

    PubMed Central

    Díaz, Jorge Luis; Vega, Marcelo; Matesevach, Ivan

    2017-01-01

    Objectives: describe our technique using hamstring graft that respects the proximal continuity of Semitendinosus and uses the superior biological potential of the distal periosteum., preserving and stressing the ST reinforce the retropulsión and dynamic control of external rotation of the knee. Here the technique, results, difficulties and foundations. Methods: The sample of this research was composed of 229 cases operated between 01/03/97 and 01/03/13 in Arthroscopy Private Center., 166 male and 63 female, the postop follow-up was 86 months. Evaluated with IKDC, Lysholm, Hamstring EMG. Comparative histology study in rabbits. Results: IKDC and Lysholm score showed 93% of very good results. Conclusion: Dynamic ACL reconstruction achieves a static-dynamic stabilization of the knee. Grafts have a plus in their biological potential (proximal continuity - osteo-periosteal insertion of the tendons in the femoral tunnel). The hamstring maintains its functionality (EMG). 93% satisfactory results (IKDC, Lysholm). It is a valid surgical option in ACL injuries.

  5. Sharing Research Results

    ERIC Educational Resources Information Center

    Ashbrook, Peggy

    2011-01-01

    There are many ways to share a collection of data and students' thinking about that data. Explaining the results of science inquiry is important--working scientists and amateurs both contribute information to the body of scientific knowledge. Students can collect data about an activity that is already happening in a classroom (e.g., the qualities…

  6. Reporting Research Results Effectively

    ERIC Educational Resources Information Center

    Volkwein, J. Fredericks

    2010-01-01

    Assessment research is at its best when it packages research results and data so that they can be digested by multiple audiences. Too many assessment researchers spend all their efforts planning and executing the research project with little attention to closing the loop at the end. If assessment findings are not communicated effectively, the…

  7. CPT Results from Ktev

    NASA Astrophysics Data System (ADS)

    Nguyen, Hogan

    2002-02-01

    We present several preliminary measurements from KTeV of the fundamental neutral K parameters, and their implications for CPT violation. A new limit is given on the sidereal time dependence of φ+-. The results are based on data collected in 1996-97.

  8. Results from ARGUS

    NASA Astrophysics Data System (ADS)

    Darden, C.

    1984-10-01

    The ARGUS collaboration reports results bearing on the fragmentation function for D*± mesons, the mass of the F± meson, the decays F±→φπ± and F±→φπ+π-π±, the decay γ'→π+π-γ and the radiative decay γ'→γΥ(3Pj).

  9. Results Are the Reason.

    ERIC Educational Resources Information Center

    Sparks, Dennis

    2000-01-01

    Author Mike Schmoker argues that data should play a crucial role before staff development begins by helping to select the most results-oriented initiatives. Staff development proposals should be based on data that indicate the initiatives have led to higher achievement. This interview discusses barriers to using data and notes the role of…

  10. Recent results from MAC

    SciTech Connect

    MAC Collaboration

    1982-05-01

    Some preliminary results from the MAC detector at PEP are presented. These include measurements of the angular distribution of ..gamma gamma.., ..mu mu.. and tau tau final states, a determination of the tau lifetime, a measurement of R, and a presentation of the inclusive muon p/sub perpendicular/ distribution for hadronic events.

  11. Recent CDF results

    SciTech Connect

    Gomez, Gervasio; /Cantabria Inst. of Phys.

    2007-11-01

    As of November of 2007, the CDF detector has recorded approximately 2.7 fb{sup -1} of data. This contribution describes some of the most recent and most relevant results from the CDF collaboration in all areas of its wide physics program, as well as some insights into the Tevatron reach for Higgs searches within the next few years.

  12. Implementation Challenges and Results

    ERIC Educational Resources Information Center

    Walters, Kirk; Sorensen, Nicholas

    2013-01-01

    This paper describes the implementation of the online and f2f summer algebra courses that were delivered in summers 2011 and 2012. These data will be used to frame the impact results presented in an earlier paper. In particular, the paper will provide a detailed picture of how the online course was structured and the types of supports provided to…

  13. 2008 Election Results

    NASA Astrophysics Data System (ADS)

    McDonough, William; Bamzai, Anjuli; Robinson, Robert

    2008-02-01

    Voting by the membership for Union and Section officers for the 2008-2010 term was completed on 10 January 2008. Voting was conducted electronically through an Internet Web site using commercial surveying software. Paper ballots were available upon request. The tallying and recording of the election was managed by AGU staff using Vovici software. The results of the election are given below.

  14. 2006 Election Results

    NASA Astrophysics Data System (ADS)

    Staudt, Amanda C.; Given, Holly K.; McDonough, William F.

    2006-02-01

    The voting by the membership for Union and Section officers for the 2006-2008 term was completed on 10 January. Voting was conducted electronically through the Internet using commercial surveying software. Paper ballots were available upon request. The tallying and recording of the elections was managed by AGU staff using the Web-Surveyor software. The results of the voting are listed below.

  15. [The applicability of results].

    PubMed

    Marín-León, I

    2015-11-01

    The ultimate aim of the critical reading of medical literature is to use the scientific advances in clinical practice or for innovation. This requires an evaluation of the applicability of the results of the studies that have been published, which begins with a clear understanding of these results. When the studies do not provide sufficient guarantees of rigor in design and analysis, the conditions necessary for the applicability of the results are not met; however, the fact that the results are reliable is not enough to make it worth trying to use their conclusions. This article explains how carrying out studies in experimental or artificial conditions often moves them away from the real conditions in which they claim to apply their conclusions. To evaluate this applicability, the article proposes evaluating a set of items that will enable the reader to determine the likelihood that the benefits and risks reported in the studies will yield the least uncertainty in the clinical arena where they aim to be applied.

  16. QCD results from CDF

    SciTech Connect

    Plunkett, R.; The CDF Collaboration

    1991-10-01

    Results are presented for hadronic jet and direct photon production at {radical}{bar s} = 1800 GeV. The data are compared with next-to-leading QCD calculations. A new limit on the scale of possible composite structure of the quarks is also reported. 12 refs., 4 figs.

  17. Type utilization of baked-smashed sweet potato and vegetables on patisserie product

    NASA Astrophysics Data System (ADS)

    Ana; Subekti, S.; Sudewi; Perdani, E. N.; Hanum, F.; Suciani, T.; Tania, V.

    2016-04-01

    The research was an experimental study in Green Skill Patisserie Course using Project-Based Learning model. It aims to complete the project development of pie named guramnis rainbow pie. Several experiments were carried out to produce a pie dough crust mixed with baked-smashed sweet potato and added with vegetables extract as the food coloring. The experiment method in order to make a better appearance or an attractive shape and to have more nutrition. In addition, the pie was filled with a mixture of sweet and sour gurame as Indonesian traditional food. By applying an organoleptic test to 10 respondents, the result shows that pie dough recipe using flour substituted by baked-smashed sweet potato with 2:1 of a ratio. Coloring pie dough adding extract vegetables (carrots, beets and celery) as color. We found that pie dough has more interesting pie color (90%) and the texture of the pie with a quite level of crispness (60%). Moreover, the pie taste is fairly (70%) and tasty (70%). Nutritional analysis results show that per size, serving guramnis rainbow pie contains energy as much as 81.72 calories, carbohydrates 12.5 grams, fat 2.32 grams and 2.77 grams of protein. The main findings are the pie appearance and taste was different compared to the previous pies because of the pie was served with gurame asam manis as the filling and had flour and cilembu sweet potato as the basic ingredients. The color of guramnis rainbow pie was resulted not only from food coloring but also from vegetables extract namely carrot (orange), bit (red), and salary (green). Thus, it had many benefits for health and adds the nutrition. The researchers recommend a further study in order to make pie dough with baked sweet potato and vegetables extract having an optimal level of crispness.

  18. Cleanroom energy benchmarking results

    SciTech Connect

    Tschudi, William; Xu, Tengfang

    2001-09-01

    A utility market transformation project studied energy use and identified energy efficiency opportunities in cleanroom HVAC design and operation for fourteen cleanrooms. This paper presents the results of this work and relevant observations. Cleanroom owners and operators know that cleanrooms are energy intensive but have little information to compare their cleanroom's performance over time, or to others. Direct comparison of energy performance by traditional means, such as watts/ft{sup 2}, is not a good indicator with the wide range of industrial processes and cleanliness levels occurring in cleanrooms. In this project, metrics allow direct comparison of the efficiency of HVAC systems and components. Energy and flow measurements were taken to determine actual HVAC system energy efficiency. The results confirm a wide variation in operating efficiency and they identify other non-energy operating problems. Improvement opportunities were identified at each of the benchmarked facilities. Analysis of the best performing systems and components is summarized, as are areas for additional investigation.

  19. Results from SAGE II

    SciTech Connect

    Nico, J.S.

    1994-10-01

    The Russian-American Gallium solar neutrino Experiment (SAGE) began the second phase of operation (SAGE II) in September of 1992. Monthly measurements of the integral flux of solar neutrinos have been made with 55 tonnes of gallium. The K-peak results of the first nine runs of SAGE II give a capture rate of 66{sub -13}{sup +18} (stat) {sub -7}{sup +5} (sys) SNU. Combined with the SAGE I result of 73{sub -16}{sup +18} (stat) {sub -7}{sup 5} (sys) SNU, the capture rate is 69{sub -11}{sup +11} (stat) {sub -7}{sup +5} (sys) SNU. This represents only 52%--56% of the capture rate predicted by different Standard Solar Models.

  20. Early results from ISO

    NASA Astrophysics Data System (ADS)

    1996-01-01

    First findings by Europe's new space telescope ISO (Infrared Space Observatory) will be announced at a press conference to be held at ESA's satellite tracking station in Villafranca, Apartado 50727 - 28080-Madrid, on Wednesday 14 February 1996 Astronomers responsible for ISO's instruments will show results ranging from materials in the planet Saturn, through the birth and death of stars, to the behaviour of colliding galaxies. All instruments are working well and even their preliminary results confirm that ISO is a unique observatory making an unprecedented exploration of the universe by infrared rays. Parallel press conferences will be held at ESA Headquarters in Paris, ESTEC Noordwijk (the Netherlands) and ESOC Darmstadt (Germany) where a live television link will be established with Villafranca and from where the media can participate in the discussion.

  1. Dosimetric results on EURECA

    SciTech Connect

    Reitz, G.

    1995-02-01

    Detector packages were exposed on the European Retrievable Carrier (EURECA) as part of the Biostack experiment inside the Exobiology and Radiation Assembly (ERA) and at several locations around EURECA. The packages consist of different plastic nuclear track detectors, nuclear emulsions and thermoluminescence dosimeters (TLD`s). Evaluation of these detectors yields data on absorbed dose and particle and LET spectra. Preliminary results of absorbed dose measurements in the EURECA dosimeter packages are reported and compared to results of the LDEF experiments. The highest dose rate measured on EURECA is 63.3 plus or minus 0.4 mGy d(exp -1) behind a shielding thickness of 0.09 g cm(exp -2) in front of the detector package.

  2. Titan - Some new results

    NASA Astrophysics Data System (ADS)

    Owen, T.; Gautier, D.

    New analyses of Voyager spectra of Titan have led to improvements in the determination of abundances of minor constituents as a function of latitude and altitude. Ground-based microwave observations have extended the Voyager results for HCN, and have demonstrated that CO is mysteriously deficient in the stratosphere. The origin of the CH4, CO, and N2 in Titan's atmosphere is still unresolved. Both primordial and evolutionary sources are compatible with the available evidence.

  3. Recent results from MAMI

    SciTech Connect

    Arends, Hans-Juergen

    2011-10-24

    The Mainz Microtron MAMI is an ideal facility to study the hadron structure with the electromagnetic probe. With the new accelerator stage (HDSM), which went into operation in 2007, high-intensity polarized electron and photon beams with energies up to 1.6 GeV are delivered to the experiments. Polarized targets and recoil polarimeters in combination with dedicated detectors are available for precision experiments in hadron physics. In this article, an overview over selected recent results is given.

  4. Results from SAGE

    SciTech Connect

    Abdurashitov, J.N.; Gavrin, V.N.; Girin, S.V.

    1996-04-01

    The Russian-American Gallium Solar Neutrino Experiment (SAGE) is described. Beginning in September 1992, SAGE II data were taken with 55 tons of Ga and with significantly reduced backgrounds. The solar neutrino flux measured by 31 extractions through October 1993 is presented. The result of 69 {+-} 10 +5/{minus}7 SNU is to be compared with a Standard Solar Model prediction of 132 SNU.

  5. ICAAS piloted simulation results

    NASA Astrophysics Data System (ADS)

    Landy, R. J.; Halski, P. J.; Meyer, R. P.

    1994-05-01

    This paper reports piloted simulation results from the Integrated Control and Avionics for Air Superiority (ICAAS) piloted simulation evaluations. The program was to develop, integrate, and demonstrate critical technologies which will enable United States Air Force tactical fighter 'blue' aircraft to achieve superiority and survive when outnumbered by as much as four to one by enemy aircraft during air combat engagements. Primary emphasis was placed on beyond visual range (BVR) combat with provisions for effective transition to close-in combat. The ICAAS system was developed and tested in two stages. The first stage, called low risk ICAAS, was defined as employing aircraft and avionics technology with an initial operational date no later than 1995. The second stage, called medium risk ICAAS, was defined as employing aircraft and avionics technology with an initial operational date no later than 1998. Descriptions of the low risk and medium risk simulation configurations are given. Normalized (unclassified) results from both the low risk and medium risk ICAAS simulations are discussed. The results show the ICAAS system provided a significant improvement in air combat performance when compared to a current weapon system. Data are presented for both current generation and advanced fighter aircraft. The ICAAS technologies which are ready for flight testing in order to transition to the fighter fleet are described along with technologies needing additional development.

  6. Certification of computational results

    NASA Technical Reports Server (NTRS)

    Sullivan, Gregory F.; Wilson, Dwight S.; Masson, Gerald M.

    1993-01-01

    A conceptually novel and powerful technique to achieve fault detection and fault tolerance in hardware and software systems is described. When used for software fault detection, this new technique uses time and software redundancy and can be outlined as follows. In the initial phase, a program is run to solve a problem and store the result. In addition, this program leaves behind a trail of data called a certification trail. In the second phase, another program is run which solves the original problem again. This program, however, has access to the certification trail left by the first program. Because of the availability of the certification trail, the second phase can be performed by a less complex program and can execute more quickly. In the final phase, the two results are compared and if they agree the results are accepted as correct; otherwise an error is indicated. An essential aspect of this approach is that the second program must always generate either an error indication or a correct output even when the certification trail it receives from the first program is incorrect. The certification trail approach to fault tolerance is formalized and realizations of it are illustrated by considering algorithms for the following problems: convex hull, sorting, and shortest path. Cases in which the second phase can be run concurrently with the first and act as a monitor are discussed. The certification trail approach are compared to other approaches to fault tolerance.

  7. GIRAFFE test results summary

    SciTech Connect

    Yokobori, S.; Arai, K.; Oikawa, H.

    1996-03-01

    A passive system can provide engineered safety features enhancing safety system reliability and plant simplicity. Toshiba has conducted the test Program to demonstrate the feasibility of the SBWR passive safety system using a full-height, integral system test facility GIRAFFE. The test facility GIRAFFE models the SBWR in full height to correctly present the gravity driving head forces with a 1/400 volume scale. The GIRAFFE test Program includes the certification tests of the passive containment cooling system (PCCS) to remove the post-accident decay heat and the gravity driven cooling system (GDCS) to replenish the reactor coolant inventory during a LOCA. The test results have confirmed the PCCS and GDCS design and in addition, have demonstrated the operation of the pCCS with the presence of a lighter-than-steam noncondensable as well as with the presence of a heavier-than-steam, noncondensable. The GIRAFFE test Program has also provided the database to qualify a best estimate thermal-hydraulic computer code TRAC. The post test analysis results have shown that TRAC can accurately predict the PCCS heat removal Performance and the containment pressure response to a LOCA. This paper summarizes the GIRAFFE test results to investigate post-LOCA PCCS heat removal performance and post-test analysis using TRAC.

  8. The Viking biology results

    NASA Technical Reports Server (NTRS)

    Klein, Harold P.

    1989-01-01

    A brief review of the purposes and the results from the Viking Biology experiments is presented, in the expectation that the lessons learned from this mission will be useful in planning future approaches to the biological exploration of Mars. Since so little was then known about potential micro-environments on Mars, three different experiments were included in the Viking mission, each one based on different assumptions about what Martian organisms might be like. In addition to the Viking Biology Instrument (VBI), important corollary information was obtained from the Viking lander imaging system and from the molecular analysis experiments that were conducted using the gas chromatograph-mass spectrometer (GCMS) instrument. No biological objects were noted by the lander imaging instrument. The GCMS did not detect any organic compounds. A description of the tests conducted by the Gas Exchange Experiment, the Labeled Release experiment, and the Pyrolytic Release experiment is given. Results are discussed. Taken as a whole, the Viking data yielded no unequivocal evidence for a Martian biota at either landing site. The results also revealed the presence of one or more reactive oxidants in the surface material and these need to be further characterized, as does the range of micro-environments, before embarking upon future searches for extant life on Mars.

  9. Explaining embodied cognition results.

    PubMed

    Lakoff, George

    2012-10-01

    From the late 1950s until 1975, cognition was understood mainly as disembodied symbol manipulation in cognitive psychology, linguistics, artificial intelligence, and the nascent field of Cognitive Science. The idea of embodied cognition entered the field of Cognitive Linguistics at its beginning in 1975. Since then, cognitive linguists, working with neuroscientists, computer scientists, and experimental psychologists, have been developing a neural theory of thought and language (NTTL). Central to NTTL are the following ideas: (a) we think with our brains, that is, thought is physical and is carried out by functional neural circuitry; (b) what makes thought meaningful are the ways those neural circuits are connected to the body and characterize embodied experience; (c) so-called abstract ideas are embodied in this way as well, as is language. Experimental results in embodied cognition are seen not only as confirming NTTL but also explained via NTTL, mostly via the neural theory of conceptual metaphor. Left behind more than three decades ago is the old idea that cognition uses the abstract manipulation of disembodied symbols that are meaningless in themselves but that somehow constitute internal "representations of external reality" without serious mediation by the body and brain. This article uniquely explains the connections between embodied cognition results since that time and results from cognitive linguistics, experimental psychology, computational modeling, and neuroscience.

  10. Pressure locking test results

    SciTech Connect

    DeWall, K.G.; Watkins, J.C.; McKellar, M.G.; Bramwell, D.

    1996-12-01

    The U.S. Nuclear Regulatory Commission (NRC), Office of Nuclear Regulatory Research, is funding the Idaho National Engineering Laboratory (INEL) in performing research to provide technical input for their use in evaluating responses to Generic Letter 95-07, {open_quotes}Pressure Locking and Thermal Binding of Safety-Related Power-Operated Gate Valves.{close_quotes} Pressure locking and thermal binding are phenomena that make a closed gate valve difficult to open. This paper discusses only the pressure locking phenomenon in a flexible-wedge gate valve; the authors will publish the results of their thermal binding research at a later date. Pressure locking can occur when operating sequences or temperature changes cause the pressure of the fluid in the bonnet (and, in most valves, between the discs) to be higher than the pressure on the upstream and downstream sides of the disc assembly. This high fluid pressure presses the discs against both seats, making the disc assembly harder to unseat than anticipated by the typical design calculations, which generally consider friction at only one of the two disc/seat interfaces. The high pressure of the bonnet fluid also changes the pressure distribution around the disc in a way that can further contribute to the unseating load. If the combined loads associated with pressure locking are very high, the actuator might not have the capacity to open the valve. The results of the NRC/INEL research discussed in this paper show that the relationship between bonnet pressure and pressure locking stem loads appears linear. The results also show that for this valve, seat leakage affects the bonnet pressurization rate when the valve is subjected to thermally induced pressure locking conditions.

  11. Lithium cell test results

    NASA Technical Reports Server (NTRS)

    Bragg, B. J.

    1977-01-01

    Three lithium SO2 cells, two lithium CF cells, and a vinyl chloride cell, all with crimped seals, and all strictly experimental, were independently discharged on resistors. Three temperatures were used and several different storage temperatures. Discharge rate generally on the nominal discharges were 0.1 amp, 0.5 amp, and 1 amp. Tests results show that the crimp seals are inadequate, especially for the SO2 cells. Normal discharges present no hazards. All cells discharge to zero. The problem of lithium cell explosions, such as occurred during off-limits testing, is discussed.

  12. Recent result from RENO

    NASA Astrophysics Data System (ADS)

    Seo, Hyunkwan; RENO Collaboration

    2016-05-01

    The Reactor Experiment for Neutrino Oscillation (RENO) started data-taking from August, 2011 and has measured the smallest neutrino mixing angle θ13 by observing the disappearance of reactor antineutrinos. Antineutrinos from the six reactors at Hanbit Nuclear Power Plant in Korea are detected and compared by the two identical detectors located in the near and far distances from the reactor array center. We present new results on precisely measured sin 22θ13 value and |Δm2 ee| based on spectral analysis using the 800 days of data sample, which are taken from August, 2011 to Dec., 2013.

  13. Results of railgun experiments

    SciTech Connect

    Hawke, R.S.; Brooks, A.L.; Fowler, C.M.; Peterson, D.R.

    1983-04-01

    During the 1979 Megagauss II conference the hypervelocity potential of railguns and the pulsed power technology needed to power them were discussed. Since then, many laboratories have initiated railgun R and D projects for a variety of potential applications. Los Alamos and Lawrence Livermore National Laboratories initiated a collaborative experimental railgun project which resulted in several successes in accelerating projectiles to high velocities, emphasized the limits on railgun operation, and indicated that the numerical modeling of railgun operation was in good agreement with the experiments.

  14. Planck 2015 Cosmological results

    NASA Astrophysics Data System (ADS)

    Tristram, Matthieu

    2015-08-01

    On behalf of the Planck collaboration, I will present the cosmological results from the 2015 release. The new release now include polarization data from both the LFI and the HFI.I will focus on the impact of the polarization on both the standard LCDM model and its basic extensions. I will compare these constraints with other cosmological probes such as BAO, gravitational lensing and redshift space distortions.LCDM is still a very good fit of the Planck CMB data. The scalar fluctuations are consistent with adiabatic modes.

  15. Recent BABAR Results

    SciTech Connect

    Eigen, Gerald

    2015-04-29

    We present herein the most recent BABAR results on direct CP asymmetry measurements in B → Xsγ, on partial branching fraction and CP asymmetry measurements in B → Xs+-, on a search for B → π/ηℓ+- decays, on a search for lepton number violation in B+ → X-+ℓ'+ modes and a study of B0 →ωω and B0 → ωφ decays.

  16. SPEAR results, 1981

    SciTech Connect

    Scharre, D.L.

    1981-09-01

    New results from SPEAR on the inclusive photon spectrum at the psi' and on J/psi radiative transitions are presented. Evidence for an eta/sub c/' candidate is observed in the psi' inclusive photon spectrum at a mass M = 3592 +- 5 MeV. A new resonance, the theta(1640) which is observed to decay into eta eta, has been seen in radiative transitions from the J/psi. The spin-parity of the l(1440), previously observed in J/psi radiative transitions and originally identified as the E(1420), has been determined to be 0/sup -/.

  17. Recent Results from Borexino

    NASA Astrophysics Data System (ADS)

    Jeschke, D.; Agostini, M.; Altenmüller, K.; Appel, S.; Atroshchenko, V.; Bellini, G.; Benziger, J.; Bick, D.; Bonfini, G.; Bravo, D.; Caccianiga, B.; Calaprice, F.; Caminata, A.; Carlini, M.; Cavalcante, P.; Chepurnov, A.; Choi, K.; D’Angelo, D.; Davini, S.; Derbin, A.; Di Noto, L.; Drachnev, I.; Etenko, A.; Fomenko, K.; Franco, D.; Gabriele, F.; Galbiati, C.; Ghiano, C.; Giammarchi, M.; Goeger-Neff, M.; Goretti, A.; Gromov, M.; Hagner, C.; Hungerford, E.; Ianni, Aldo; Ianni, Andrea; Jany, A.; Jedrzejczak, K.; Jeschke, D.; Kobychev, V.; Korablev, D.; Korga, G.; Kryn, D.; Laubenstein, M.; Lehnert, B.; Litvinovich, E.; Lombardi, F.; Lombardi, P.; Ludhova, L.; Lukyanchenko, G.; Machulin, I.; Manecki, S.; Maneschg, W.; Manuzio, G.; Marcocci, S.; Meroni, E.; Meyer, M.; Miramonti, L.; Misiaszek, M.; Montuschi, M.; Mosteiro, P.; Muratova, V.; Neumair, B.; Oberauer, L.; Obolensky, M.; Ortica, F.; Pallavicini, M.; Papp, L.; Pocar, A.; Ranucci, G.; Razeto, A.; Re, A.; Romani, A.; Roncin, R.; Rossi, N.; Schönert, S.; Semenov, D.; Skorokhvatov, M.; Smirnov, O.; Sotnikov, A.; Sukhotin, S.; Suvorov, Y.; Tartaglia, R.; Testera, G.; Thurn, J.; Toropova, M.; Unzhakov, E.; Vishneva, A.; Vogelaar, R. B.; von Feilitzsch, F.; Wang, H.; Weinz, S.; Winter, J.; Wojcik, M.; Wurm, M.; Yokley, Z.; Zaimidoroga, O.; Zavatarelli, S.; Zuber, K.; Zuzel, G.

    2017-01-01

    The Borexino experiment is taking data since 2007 at the Laboratori Nazionali del Gran Sasso in Italy accomplishing outstanding achievements in the field of neutrino physics. Its success is strongly based on the unprecedented ultra-high radio-purity of the inner scintillator core. The main features of the detector and the impressive results for solar and geo-neutrinos obtained by Borexino so far are summarized. The main focus is laid on the most recent results, i.e. the first real-time measurement of the solar pp neutrino flux and the detection of the signal induced by geo-neutrinos with a significance as high as 5.9σ. The measurement of the pp neutrino flux represents a direct probe of the major mechanism of energy production in the Sun and its observation at a significance of 10σ proves the stability of the Sun over a time of at least 105 years. It further puts Borexino in the unique position of being capable to test the MSW-LMA paradigm across the whole solar energy range. The geo-neutrino data allow to infer information concerning important geophysical properties of the Earth that are also discussed. The perspectives of the final stage of the Borexino solar neutrino program that are centered on the goal of measuring the CNO neutrinos that so far escaped any observation are outlined.

  18. Spacelab Science Results Study

    NASA Technical Reports Server (NTRS)

    Naumann, R. J.; Lundquist, C. A.; Tandberg-Hanssen, E.; Horwitz, J. L.; Germany, G. A.; Cruise, J. F.; Lewis, M. L.; Murphy, K. L.

    2009-01-01

    Beginning with OSTA-1 in November 1981 and ending with Neurolab in March 1998, a total of 36 Shuttle missions carried various Spacelab components such as the Spacelab module, pallet, instrument pointing system, or mission peculiar experiment support structure. The experiments carried out during these flights included astrophysics, solar physics, plasma physics, atmospheric science, Earth observations, and a wide range of microgravity experiments in life sciences, biotechnology, materials science, and fluid physics which includes combustion and critical point phenomena. In all, some 764 experiments were conducted by investigators from the U.S., Europe, and Japan. The purpose of this Spacelab Science Results Study is to document the contributions made in each of the major research areas by giving a brief synopsis of the more significant experiments and an extensive list of the publications that were produced. We have also endeavored to show how these results impacted the existing body of knowledge, where they have spawned new fields, and if appropriate, where the knowledge they produced has been applied.

  19. Unfavourable results in pollicisation

    PubMed Central

    Thatte, Mukund R.; Nehete, Sushil; Garude, Kirti; Mehta, Rujuta

    2013-01-01

    Pollicisation of the index finger is perhaps one of the most complex and most rewarding operations in hand and plastic surgery. It however has a steep learning curve and demands very high skill levels and experience. There are multiple pitfalls and each can result in an unfavourable result. In essence we need to: Shorten the Index, recreate the carpo metacarpal joint from the metacarpo phalangeal (MP) joint, rotate the digit by about 120° for pulp to pulp pinch, palmarly abduct by 40-50° to get a new first web gap, Shorten and readjust the tension of the extensors, re attach the intrinsics to form a thenar eminence capable of positioning the new thumb in various functional positions and finally close the flaps forming a new skin envelope. The author has performed over 75 pollicisations personally and has personal experience of some of the issues raised there. The steps mentioned therefore are an algorithm for helping the uninitiated into these choppy waters. PMID:24501467

  20. Maquet Osteotomy, Results

    PubMed Central

    Díaz, Jorge Luis; Vega, Marcelo; Matesevach, Ivan

    2017-01-01

    Objectives: The objectives are to assess the results and to discuss the indications for Maquet osteotomy in patients with patellofemoral osteoarthritis. Methods: Retrospective study of a series of 32 patients (4 bilateral, that is to say, 36 knees) operated between March 1999 and October 2013 in " Arthroscopy Private Center ", 12 male and 20 female, average age 59 years with an average postoperative surgery outcomes of 53 months. The technique consists of an arthroscopic procedure to treat joint lesions and a tibial tuberosity osteotomy of 5 cm long, by embedding a 1cm subsequent graft taken from the same metaphysis and fixed with 2 screws. Results: All patients had significant improvement, evaluated with Kujala’s score (54 points preop to 86 points postop) and Guillamon Ferguson’s criteria (27.2 very good and 60.7 good). The complication rate was acceptable. Conclusion: The available technics are surgeries on proximal soft structures, osteotomies of tibial tuberosity and patellofemoral arthroplasty. Maquet osteotomy is an excellent procedure when the patient’s selection is right. Obtaining the graft from the same metaphysis simplified the procedure.

  1. CDF results on top

    SciTech Connect

    Beretvas, A.; CDF Collaboration

    1995-08-01

    CDF has established the existence of the top quark. Results from p{anti p} collisions at {radical}s = 1.8 TeV are presented. In the dilepton final state the authors found seven events with a background of 1.3 {+-} 0.3. In the e, {mu} + {nu} + jets channel with a b identified via a secondary vertex detector (SVX), they found twenty one events with a background of 5.5 {+-} 1.8. They measure the top quark mass to be 176 {+-} 8 (stat) {+-} 10 (syst) GeV/c{sup 2}, and the t{anti t} production cross section to be 7.6{sub {minus}2.0}{sup +2.4} pb. The integrated luminosity for the results presented in this talk is 67 pb{sup {minus}1}. The CDF detector needs to be upgraded for the next run. The integrated luminosity for the next run is expected to be more than 1,000 pb{sup {minus}1}.

  2. Organic Separation Test Results

    SciTech Connect

    Russell, Renee L.; Rinehart, Donald E.; Peterson, Reid A.

    2014-09-22

    Separable organics have been defined as “those organic compounds of very limited solubility in the bulk waste and that can form a separate liquid phase or layer” (Smalley and Nguyen 2013), and result from three main solvent extraction processes: U Plant Uranium Recovery Process, B Plant Waste Fractionation Process, and Plutonium Uranium Extraction (PUREX) Process. The primary organic solvents associated with tank solids are TBP, D2EHPA, and NPH. There is concern that, while this organic material is bound to the sludge particles as it is stored in the tanks, waste feed delivery activities, specifically transfer pump and mixer pump operations, could cause the organics to form a separated layer in the tank farms feed tank. Therefore, Washington River Protection Solutions (WRPS) is experimentally evaluating the potential of organic solvents separating from the tank solids (sludge) during waste feed delivery activities, specifically the waste mixing and transfer processes. Given the Hanford Tank Waste Treatment and Immobilization Plant (WTP) waste acceptance criteria per the Waste Feed Acceptance Criteria document (24590-WTP-RPT-MGT-11-014) that there is to be “no visible layer” of separable organics in the waste feed, this would result in the batch being unacceptable to transfer to WTP. This study is of particular importance to WRPS because of these WTP requirements.

  3. First results from CARIBU

    NASA Astrophysics Data System (ADS)

    Savard, Guy

    2011-10-01

    The Californium Rare Ion Breeder Upgrade (CARIBU) of the ATLAS superconducting linac facility aims at providing low energy and reaccelerated neutron-rich radioactive beams to address key nuclear physics, astrophysics and application issues. These beams are obtained from fission fragments of a 1 Ci 252Cf source, thermalized and collected into a low-energy particle beam by a helium gas catcher, mass analyzed by an isobar separator, and charge breed to higher charge states for acceleration in ATLAS. The method described is fast and universal and short-lived isotope yield scale essentially with Californium fission yields. The facility is now commissioned and operating with a 100 mCi source which has yielded extracted low-energy mass separated radioactive beams at intensities in excess of 100000 ions per second. Radioactive beams have been charge bred with an efficiency of up to 12% and reaccelerated to 6 MeV/u. Commissioning results, together with the results from first astrophysics experiments at CARIBU using the beams from the 100 mCi source will be presented. The final 1 Ci source is currently under fabrication and is expected to be installed by the end of the year. This work was supported by the US DOE, Office of Nuclear Physics, under contract DE-AC02-06CH11357.

  4. Recent Results from Phobos

    SciTech Connect

    Garcia, Edmundo; Betts, R. R.; Garcia, E.; Halliwell, C.; Hofman, D. J.; Hollis, R. S.; Iordanova, A.; Sagerer, J.; Smith, C. E.; Back, B. B.; Baker, M. D.; Barton, D. S.; Carroll, A.; Chai, Z.; George, N.; Hauer, M.; Holzman, B.; Pak, R.; Seals, H.; Sedykh, I.

    2007-02-12

    The PHOBOS detector is one of four heavy ion experiments at the Relativistic Heavy Ion Collider at Brookhaven National Laboratory. In this paper we will review some of the results of PHOBOS from the data collected in p+p, d+Au and Au+Au collisions at nucleon-nucleon center-of-mass energies up to 200 GeV. Evidence is found of the formation of a very high energy density and highly interactive system, which can not be described in terms of hadrons, and has a relatively low baryon density. There is evidence that the system formed is thermalized to a certain degree. Scaling with the number of participants and extended longitudinal scaling behavior are also observed in distributions of produced charged particles.

  5. Iron Mountain Electromagnetic Results

    SciTech Connect

    Gail Heath

    2012-07-01

    Iron Mountain Mine is located seventeen miles northwest of Redding, CA. After the completion of mining in early 1960s, the mine workings have been exposed to environmental elements which have resulted in degradation in water quality in the surrounding water sheds. In 1985, the EPA plugged ore stoops in many of the accessible mine drifts in an attempt to restrict water flow through the mine workings. During this process little data was gathered on the orientation of the stoops and construction of the plugs. During the last 25 years, plugs have begun to deteriorate and allow acidic waters from the upper workings to flow out of the mine. A team from Idaho National Laboratory (INL) performed geophysical surveys on a single mine drift and 3 concrete plugs. The project goal was to evaluate several geophysical methods to determine competence of the concrete plugs and orientation of the stopes.

  6. FIRE Science Results 1989

    NASA Technical Reports Server (NTRS)

    Mcdougal, David S. (Editor)

    1990-01-01

    FIRE (First ISCCP Regional Experiment) is a U.S. cloud-radiation research program formed in 1984 to increase the basic understanding of cirrus and marine stratocumulus cloud systems, to develop realistic parameterizations for these systems, and to validate and improve ISCCP cloud product retrievals. Presentations of results culminating the first 5 years of FIRE research activities were highlighted. The 1986 Cirrus Intensive Field Observations (IFO), the 1987 Marine Stratocumulus IFO, the Extended Time Observations (ETO), and modeling activities are described. Collaborative efforts involving the comparison of multiple data sets, incorporation of data measurements into modeling activities, validation of ISCCP cloud parameters, and development of parameterization schemes for General Circulation Models (GCMs) are described.

  7. System results from FRECOPA

    SciTech Connect

    Durin, C.; Berthoud, L.; Mandeville, J.C.

    1995-02-01

    The work carried out over the past three years on FRECOPA and the LDEF has enabled a large quantity of information to be collected, part of which has already been exploited. As far as CNES is concerned, the major spin-offs of this mission mainly focus on the orbital environment and the behavior of materials in such an environment. With respect to the environment, the authors shall develop the lessons learned from expert appraisals on impacts by microparticles, which are the main feature observed in this area. As for the materials, the results show a variety of behavior when subjected to the space environment and even now constitute a wealth of information for the designing and validation of future mechanical systems. Apart from these direct spin-offs, there are repercussions on in-flight and ground testing, the calibration of test benches and improvements to simulation models.

  8. System results from FRECOPA

    NASA Technical Reports Server (NTRS)

    Durin, Christian; Berthoud, Lucinda; Mandeville, Jean-Claude

    1995-01-01

    The work carried out over the past three years on FRECOPA and the LDEF has enabled a large quantity of information to be collected, part of which has already been exploited. As far as CNES is concerned, the major spin-offs of this mission mainly focus on the orbital environment and the behavior of materials in such an environment. With respect to the environment, the authors shall develop the lessons learned from expert appraisals on impacts by microparticles, which are the main feature observed in this area. As for the materials, the results show a variety of behavior when subjected to the space environment and even now constitute a wealth of information for the designing and validation of future mechanical systems. Apart from these direct spin-offs, there are repercussions on in-flight and ground testing, the calibration of test benches and improvements to simulation models.

  9. 2012 election results

    NASA Astrophysics Data System (ADS)

    Robinson, Robert; Tetzlaff, Doerthe

    2012-10-01

    On 4 October 2012, AGU members completed voting for the 2013-2014 leadership term. Union officers, Board members, section and focus group officers, and student and early career representatives to the Council were elected. All members who joined or renewed their membership by 1 July 2012 were eligible to vote in this year's leadership election. The vote was held electronically, and access to voting was provided to all eligible voters for a period of 31 days. The voting was conducted by Survey and Ballot Systems, Inc. (SBS). SBS, which offers election planning and management services, provided unique login credentials and other support services for eligible voters throughout the election. Voting results were certified by SBS on 8 October and by the AGU Tellers Committee on 9 October. The overall participation rate was 21.9%, an increase over previous AGU elections.

  10. Top physics: CDF results

    SciTech Connect

    K. Bloom

    2004-06-23

    The top quark plays an important role in the grand scheme of particle physics, and is also interesting on its own merits. We present recent results from CDF on top-quark physics based on 100-200 pb{sup -1} of p{bar p} collision data. We have measured the t{bar t} cross section in different decay modes using several different techniques, and are beginning our studies of top-quark properties. New analyses for this conference include a measurement of {sigma}{sub t{bar t}} in the lepton-plus-jets channel using a neural net to distinguish signal and background events, and measurements of top-quark branching fractions.

  11. Viscosupplementation: techniques, indications, results.

    PubMed

    Legré-Boyer, V

    2015-02-01

    Viscosupplementation by hyaluronic acid (HA) injections is frequently used for local treatment of osteoarthritis (OA), due to ease of use and good tolerance. A profusion of linear or reticulated HA derivates are marketed, with varied characters and levels of evidence. Viscosupplementation has demonstrated moderate but significant efficacy (20%) versus placebo in terms of pain and function, with a high rate of responders (60-70%) in knee osteoarthritis. It allows reduced administration of opioid analgesics and NSAIDs, with improved risk/benefit ratio, and may delay joint replacement. Cartilage protection remains to be proven. Clinical efficacy shows 1-4 weeks' later onset than corticosteroids, but is maintained for 6 or even 12 months. Systematic association of corticosteroid and HA injection is not justified, and an interval has to be left before undertaking arthroplasty. Intra-articular injection of HA requires a skilled specialist, and may be difficult in a non-swollen joint; some tips and tricks may be helpful. In other joints than the knee, radiologic or ultrasound guidance is recommended. The efficacy of viscosupplementation is a matter of ongoing debate, after discordant findings in some meta-analyses. Some poor results may be due to inappropriate use of HA injections, poorly adapted to the patient's OA phenotype. Viscosupplementation is a treatment for chronic moderate symptomatic OA, and not for flares with joint swelling. Application in sport-related chondropathy has yet to be properly assessed. The optimal response profile remains to be determined. The ideal indication in the knee seems to be moderate femorotibial OA without swelling. Results have been generally disappointing in hip osteoarthritis but promising in OA of the ankle and shoulder (with and without rotator cuff tear). Further studies are needed to determine response profile and optimal treatment schedule, according to the joint.

  12. Local tumour ablation for localized kidney cancer: Practice patterns in Canada

    PubMed Central

    Trudeau, Vincent; Larcher, Alessandro; Dell’Oglio, Paolo; Boehm, Katharina; Bishr, Mohamed; Karakiewicz, Pierre I.

    2015-01-01

    Introduction: Local tumour ablation (LTA) is a recommended option for the treatment of localized kidney cancer in nonsurgical candidates. We performed a survey to describe the practice patterns of this procedure in Canada. Methods: An electronic survey was sent by email to all urologists registered to the Canadian Urological Association (CUA). Urologists were queried about general demographic information, LTA availability at their institution (and reasons for non-availability, if it was the case), as well as the type and context of LTA use. Results: Overall, 103 individual responses were obtained (response rate of 19.5%). Of those, 58 (56.3%) had access to LTA at their institution. Urologists who had access to LTA were more likely to work at an academic institution (69 vs. 16%, p<0.001). Among individuals who did not use LTA, the main reasons were lack of staff, such as radiologists, who can assist and/or perform the procedure (64%); and lack of expertise with the procedure (62%). Among urologists who had access to LTA, percutaneous radiofrequency and cryoablation were the most commonly used (72% and 21%, respectively); however, urologists were rarely involved in those procedures (12%). Conclusions: In this national survey, we found that a significant proportion of Canadian urologists did not have access to LTA. We also found that when LTA was performed, urologists were rarely involved in the procedures. Those findings represent significant areas for improvement in the access to LTA. The conclusions of this study are limited by the low response rate. PMID:26788232

  13. Recent Dama Results

    NASA Astrophysics Data System (ADS)

    Bernabei, R.; Belli, P.; Montecchia, F.; Nozzoli, F.; Cappella, F.; D'Angelo, A.; Incicchitti, A.; Prosperi, D.; Cerulli, R.; Dai, C. J.; He, H. L.; Kuang, H. H.; Ma, J. M.; Ye, Z. P.

    2006-04-01

    DAMA is an observatory for rare processes and it is operative deep underground at the Gran Sasso National Laboratory of the I.N.F.N. The experiment developes and uses low background scintillator for rare processes investigation. In this paper, after a short presentation of the main DAMA set-ups, the DAMA/NaI apparatus (≃ 100 kg highly radiopure NaI(Tl)) and its main results in the Dark Matter field will be addressed. This experiment, in particular, has effectively investigated the presence of a Dark Matter particle component in the galactic halo by exploiting the model-independent annual modulation signature over seven annual cycles (total exposure of 107731 kg × day), obtaining a 6.3 σ C.L. model-independent evidence for such a presence. In addition, some corollary model-dependent quests to investigate the nature of a candidate particle will be recalled. The new additional analysis for a pseudoscalar and for a scalar bosonic candidate (whose detection only involves electrons and photons/X-rays) will be addressed as well. Some perspectives of the second generation DAMA/LIBRA set-up (≃ 250 kg highly radiopure NaI(Tl)), presently in measurement deep underground, will be mentioned.

  14. Results from SNO

    SciTech Connect

    Chan, Yuen-dat

    2001-10-01

    The Sudbury Neutrino Observatory (SNO) is an underground heavy water Cherenkov detector for studying solar neutrinos. SNO is capable of performing both flavor sensitive and flavor blind measurements of the solar neutrino flux. The first charged current (CC) measurement is found to be: {psi}{sub SNO}{sup CC}({nu}{sub e}) = 1.75 {+-} 0.07(stat.){sub -0.11}{sup +0.12}(sys.) {+-} 0.05 (theor.) x 10{sup 6} cm{sup -2}s{sup -1} and the elastic scattering fluxes (ES) is: {psi}{sub SNO}{sup ES}({nu}{sub x}) = 2.39 {+-} 0.34(stat.){sub -0.14}{sup +0.16} (sys.) x 10{sup 6} cm{sup -2}s{sup -1}. The {psi}{sub SNO}{sup CC}({nu}{sub e}) result, when combined with the high statistics elastic scattering (ES) measurement from Super-Kamiokande, provide a strong evidence for solar neutrino flavor transformation (3.3{sigma}). The deduced total solar neutrino flux is in good agreement with standard solar model predictions. No significant distortion in the energy spectrum is observed.

  15. ALOS-2 initial results

    NASA Astrophysics Data System (ADS)

    Kankaku, Yukihiro; Suzuki, Shinichi; Shimada, Masanobu

    2015-10-01

    The Advanced Land Observing Satellite-2 (ALOS-2) was launched from Tanegashima Space Center by H-IIA rocket successfully on 24th May 2014. ALOS-2 carries the Phased Array type L-band Synthetic Aperture Radar-2 (PALSAR-2) as the state-of-the-art L-band SAR system which succeeds to PALSAR onboard ALOS. PALSAR-2 uses almost whole bandwidth allocated for L-band active sensor of Earth Exploration Satellites Service specified by the Radio Regulation in order to realize the high resolution observation, and also, it transmits more than 6 kW power for lower Noise Equivalent Sigma Zero using 180 TRMs driven by Gallium Nitride (GaN) amplifier which is the first use in space. Furthermore, because ALOS-2 carries the SAR system only, PALSAR-2 antenna can be mounted under the satellite body. It enables to observe right-/left-looking observation by satellite maneuvering. And the high accuracy orbit control to maintain the satellite within 500 m radius tube against the reference orbit enables high coherence for the InSAR processing. Using these new technologies, ALOS-2 has been operating to fulfill the mission requirements such as disaster monitoring and so on. This document introduces the initial result of ALOS-2 from the first year operation.

  16. Simpler images, better results

    NASA Astrophysics Data System (ADS)

    Chance, Britton

    1999-03-01

    The very rapid development of optical technology has followed a pattern similar to that of nuclear magnetic resonance: first, spectroscopy and then imaging. The accomplishments in spectroscopy have been significant--among them, early detection of hematomas and quantitative oximetry (assuming that time and frequency domain instruments are used). Imaging has progressed somewhat later. The first images were obtained in Japan and USA a few years ago, particularly of parietal stimulation of the human brain. Since then, rapid applications to breast and limb, together with higher resolution of the brain now make NIR imaging of functional activation and tumor detection readily available, reliable and affordable devices. The lecture has to do with the applications of imaging to these three areas, particularly to prefrontal imaging of cognitive function, of breast tumor detection, and of localized muscle activation in exercise. The imaging resolution achievable in functional activation appears to be FWHM of 4 mm. The time required for an image is a few seconds or even much less. Breast image detection at 50 microsecond(s) ec/pixel results in images obtainable in a few seconds or shorter times (bandwidths of the kHz are available). Finally, imaging of the body organs is under study in this laboratory, particularly in the in utero fetus. It appears that the photon migration theory now leads to the development of a wide number of images for human subject tissue spectroscopy and imaging.

  17. CTF Challenge: Result Summary

    PubMed Central

    Marabini, Roberto; Carragher, Bridget; Chen, Shaoxia; Chen, James; Cheng, Anchi; Downing, Kenneth H.; Frank, Joachim; Grassucci, Robert A.; Heymann, J. Bernard; Jiang, Wen; Jonic, Slavica; Liao, Hstau Y.; Ludtke, Steven J.; Patwari, Shail; Piotrowski, Angela L.; Quintana, Adrian; Sorzano, Carlos O.S.; Stahlberg, Henning; Vargas, Javier; Voss, Neil R.; Chiu, Wah; Carazo, Jose M.

    2015-01-01

    Image formation in bright field electron microscopy can be described with the help of the contrast transfer function (CTF). In this work the authors describe the “CTF Estimation Challenge”, called by the Madrid Instruct Image Processing Center (I2PC) in collaboration with the National Center for Macromolecular Imaging (NCMI) at Houston. Correcting for the effects of the CTF requires accurate knowledge of the CTF parameters, but these have often been difficult to determine. In this challenge, researchers have had the opportunity to test their ability in estimating some of the key parameters of the electron microscope CTF on a large micrograph data set produced by well-known laboratories on a wide set of experimental conditions. This work presents the first analysis of the results of the CTF Estimation Challenge, including an assessment of the performance of the different software packages under different conditions, so as to identify those areas of research where further developments would be desirable in order to achieve high-resolution structural information. PMID:25913484

  18. SAA drift: Experimental results

    NASA Astrophysics Data System (ADS)

    Grigoryan, O. R.; Romashova, V. V.; Petrov, A. N.

    According to the paleomagnetic analysis there are variations of Earth’s magnetic field connected with magnetic moment changing. These variations affect on the South Atlantic Anomaly (SAA) location. Indeed different observations approved the existence of the SAA westward drift rate (0.1 1.0 deg/year) and northward drift rate (approximately 0.1 deg/year). In this work, we present the analysis of experimental results obtained in Scobeltsyn Institute of Nuclear Physics, Moscow State University (SINP MSU) onboard different Earth’s artificial satellites (1972 2003). The fluxes of protons with energy >50 MeV, gamma quanta with energy >500 keV and neutrons with energy 0.1 1.0 MeV in the SAA region have been analyzed. The mentioned above experimental data were obtained onboard the orbital stations Salut-6 (1979), MIR (1991, 1998) and ISS (2003) by the similar experimental equipment. The comparison of the data obtained during these two decades of investigations confirms the fact that the SAA drifts westward. Moreover the analysis of fluxes of electrons with energy about hundreds keV (Cosmos-484 (1972) and Active (Interkosmos-24, 1991) satellites) verified not only the SAA westward drift but northward drift also.

  19. LSND neutrino oscillation results

    SciTech Connect

    Louis, W.C.; LSND Collaboration

    1996-10-01

    The LSND (Liquid Scintillator Neutrino Detector) experiment at Los Alamos has conducted a search for muon antineutrino {r_arrow} electron antineutrino oscillations using muon neutrinos from antimuon decay at rest. The electron antineutrinos are detected via the reaction electron antineutrino + proton {r_arrow} positron + neutron, correlated with the 2.2-MeV gamma from neutron + proton {r_arrow} deuteron + gamma. The use of tight cuts to identify positron events with correlated gamma rays yields 22 events with positron energy between 36 and 60 MeV and only 4.6 {+-} 0.6 background events. The probability that this excess is due entirely to a statistical fluctuation is 4.1 {times} 10{sup -8}. A chi-squared fit to the entire positron sample results in a total excess of 51.8 {sup +18.7}{sub -16.9} {+-} 8.0 events with positron energy between 20 and 60 MeV. If attributed to muon antineutrino {r_arrow} electron antineutrino oscillations, this corresponds to an oscillation probability (averaged over the experimental energy and spatial acceptance) of (0.31 {+-} 0.12 {+-} 0.05){percent}. 10 refs., 7 figs., 1 tab.

  20. LSND neutrino oscillation results

    SciTech Connect

    White, D.H.; LSND Collaboration

    1997-11-01

    The LSND experiment at Los Alamos has conducted a search for {anti v}{sub {mu}} {yields} {anti v}{sub e} oscillations using {anti v}{sub {mu}} from {mu}{sup +} decay at rest. The {anti v}{sub e} are detected via the reaction {anti v}{sub e} p {yields} e{sup +}n, correlated with the 2.2 MeV {gamma} from n p {yields} d {gamma}. The use of tight cuts to identify e{sup +} events with correlated {gamma} rays yielded 22 events with e{sup +} energy between 36 and 60 MeV and only 4.6 {+-} 0.6 background events. The probability that this excess is due entirely to a statistical fluctuation is 4.1 {times} 10{sup {minus}8}. A {chi}{sup 2} fit to the entire e{sup +} sample results in a total excess of 51.8{sub {minus}16.9}{sup +18.7} {+-} 8.0 events with e{sup +} energy between 20 and 60 MeV. If attributed to {anti v}{sub {mu}} {yields} {anti v}{sub e} oscillations, this corresponds to an oscillation probability (averaged over the experimental energy and spatial acceptance) of 0.31 {+-} 0.12 {+-} 0.05%.

  1. Climax granite test results

    SciTech Connect

    Ramspott, L.D.

    1980-01-15

    The Lawrence Livermore Laboratory (LLL), as part of the Nevada Nuclear Waste Storage Investigations (NNWSI) program, is carrying out in situ rock mechanics testing in the Climax granitic stock at the Nevada Test Site (NTS). This summary addresses only those field data taken to date that address thermomechanical modeling for a hard-rock repository. The results to be discussed include thermal measurements in a heater test that was conducted from October 1977 through July 1978, and stress and displacement measurements made during and after excavation of the canister storage drift for the Spent Fuel Test (SFT) in the Climax granite. Associated laboratory and field measurements are summarized. The rock temperature for a given applied heat load at a point in time and space can be adequately modeled with simple analytic calculations involving superposition and integration of numerous point source solutions. The input, for locations beyond about a meter from the source, can be a constant thermal conductivity and diffusivity. The value of thermal conductivity required to match the field data is as much as 25% different from laboratory-measured values. Therefore, unless we come to understand the mechanisms for this difference, a simple in situ test will be required to obtain a value for final repository design. Some sensitivity calculations have shown that the temperature field is about ten times more sensitive to conductivity than to diffusivity under the test conditions. The orthogonal array was designed to detect anisotropy. After considering all error sources, anisotropic efforts in the thermal field were less than 5 to 10%.

  2. [SENTIERI Project: results].

    PubMed

    Crocetti, Emanuele; Pirastu, Roberta; Buzzoni, Carlotta; Minelli, Giada; Manno, Valerio; Bruno, Caterina; Fazzo, Lucia; Iavarone, Ivano; Pasetto, Roberto; Ricci, Paolo; Zona, Amerigo; Conti, Susanna; Comba, Pietro

    2014-01-01

    Of the 18 National Priority Contaminated Sites (NPCSs) analysed in this Report, some have a single source of environmental contamination (such as fluoro-edenite in Biancavilla). In most cases, however, we are looking at multiple heterogeneous sources of contamination. In this respect, the a priori causal evaluation of the association between diseases and environmental exposures in NPCSs, based on epidemiological evidence, can help trace the health impact back to specific types of environmental exposure. There are several cases in which the project's findings have been consistent with a priori evidence: stomach cancer (both genders, excess cancer incidence) in the Fidenza NPCS; stomach cancer (women, excess mortality, cancer incidence and hospital discharges) in the Laguna di Grado e Marano NPCS; excess hospitalisation from respiratory diseases in Brescia-Caffaro, Milazzo and Terni Papigno NPCSs; excesses for non-Hodgkin lymphomas and melanoma (incidence and hospitalisation in men and women) and breast cancer (incidence and hospital discharges, women) in Brescia-Caffaro NPCS. In preorder to properly evaluate the population's health profile, we must also observe whether results remain consistent for all three health outcomes or in both genders. The first is the case of excess mortality, cancer incidence and hospital discharges for bladder cancer (men) in Porto Torres and diseases of the urinary tract in the Basso bacino del fiume Chienti NPCS). Gender consistency is observed, for instance, for all cancer in Bolzano, Porto Torres, Venice, Litorale Domizio Flegreo, Priolo, and Taranto, for all causes in Taranto, Litorale Domizio Flegreo and Trieste. The health impact in the various NPCSs needs to be considered carefully and used as a springboard for further analytical research that could confirm and explain causal links to specific environmental exposures. The observations can, however, already be considered as a basis for mandatory primary prevention measures.

  3. Overview of MAST results

    NASA Astrophysics Data System (ADS)

    Chapman, I. T.; Adamek, J.; Akers, R. J.; Allan, S.; Appel, L.; Asunta, O.; Barnes, M.; Ben Ayed, N.; Bigelow, T.; Boeglin, W.; Bradley, J.; Brünner, J.; Cahyna, P.; Carr, M.; Caughman, J.; Cecconello, M.; Challis, C.; Chapman, S.; Chorley, J.; Colyer, G.; Conway, N.; Cooper, W. A.; Cox, M.; Crocker, N.; Crowley, B.; Cunningham, G.; Danilov, A.; Darrow, D.; Dendy, R.; Diallo, A.; Dickinson, D.; Diem, S.; Dorland, W.; Dudson, B.; Dunai, D.; Easy, L.; Elmore, S.; Field, A.; Fishpool, G.; Fox, M.; Fredrickson, E.; Freethy, S.; Garzotti, L.; Ghim, Y. C.; Gibson, K.; Graves, J.; Gurl, C.; Guttenfelder, W.; Ham, C.; Harrison, J.; Harting, D.; Havlickova, E.; Hawke, J.; Hawkes, N.; Hender, T.; Henderson, S.; Highcock, E.; Hillesheim, J.; Hnat, B.; Holgate, J.; Horacek, J.; Howard, J.; Huang, B.; Imada, K.; Jones, O.; Kaye, S.; Keeling, D.; Kirk, A.; Klimek, I.; Kocan, M.; Leggate, H.; Lilley, M.; Lipschultz, B.; Lisgo, S.; Liu, Y. Q.; Lloyd, B.; Lomanowski, B.; Lupelli, I.; Maddison, G.; Mailloux, J.; Martin, R.; McArdle, G.; McClements, K.; McMillan, B.; Meakins, A.; Meyer, H.; Michael, C.; Militello, F.; Milnes, J.; Morris, A. W.; Motojima, G.; Muir, D.; Nardon, E.; Naulin, V.; Naylor, G.; Nielsen, A.; O'Brien, M.; O'Gorman, T.; Ono, Y.; Oliver, H.; Pamela, S.; Pangione, L.; Parra, F.; Patel, A.; Peebles, W.; Peng, M.; Perez, R.; Pinches, S.; Piron, L.; Podesta, M.; Price, M.; Reinke, M.; Ren, Y.; Roach, C.; Robinson, J.; Romanelli, M.; Rozhansky, V.; Saarelma, S.; Sangaroon, S.; Saveliev, A.; Scannell, R.; Schekochihin, A.; Sharapov, S.; Sharples, R.; Shevchenko, V.; Silburn, S.; Simpson, J.; Storrs, J.; Takase, Y.; Tanabe, H.; Tanaka, H.; Taylor, D.; Taylor, G.; Thomas, D.; Thomas-Davies, N.; Thornton, A.; Turnyanskiy, M.; Valovic, M.; Vann, R.; Walkden, N.; Wilson, H.; van Wyk, F.; Yamada, T.; Zoletnik, S.; MAST; MAST Upgrade Teams

    2015-10-01

    The Mega Ampère Spherical Tokamak (MAST) programme is strongly focused on addressing key physics issues in preparation for operation of ITER as well as providing solutions for DEMO design choices. In this regard, MAST has provided key results in understanding and optimizing H-mode confinement, operating with smaller edge localized modes (ELMs), predicting and handling plasma exhaust and tailoring auxiliary current drive. In all cases, the high-resolution diagnostic capability on MAST is complemented by sophisticated numerical modelling to facilitate a deeper understanding. Mitigation of ELMs with resonant magnetic perturbations (RMPs) with toroidal mode number nRMP = 2, 3, 4, 6 has been demonstrated: at high and low collisionality; for the first ELM following the transition to high confinement operation; during the current ramp-up; and with rotating nRMP = 3 RMPs. nRMP = 4, 6 fields cause less rotation braking whilst the power to access H-mode is less with nRMP = 4 than nRMP = 3, 6. Refuelling with gas or pellets gives plasmas with mitigated ELMs and reduced peak heat flux at the same time as achieving good confinement. A synergy exists between pellet fuelling and RMPs, since mitigated ELMs remove fewer particles. Inter-ELM instabilities observed with Doppler backscattering are consistent with gyrokinetic simulations of micro-tearing modes in the pedestal. Meanwhile, ELM precursors have been strikingly observed with beam emission spectroscopy (BES) measurements. A scan in beta at the L-H transition shows that pedestal height scales strongly with core pressure. Gyro-Bohm normalized turbulent ion heat flux (as estimated from the BES data) is observed to decrease with increasing tilt of the turbulent eddies. Fast ion redistribution by energetic particle modes depends on density, and access to a quiescent domain with ‘classical’ fast ion transport is found above a critical density. Highly efficient electron Bernstein wave current drive (1 A W-1) has been achieved

  4. Neutronics, steady-state, and transient analyses for the Poland MARIA reactor for irradiation testing of LEU lead test fuel assemblies from CERCA : ANL independent verification results.

    SciTech Connect

    Garner, P. L.; Hanan, N. A.

    2011-06-07

    The MARIA reactor at the Institute of Atomic Energy (IAE) in Swierk (30 km SE of Warsaw) in the Republic of Poland is considering conversion from high-enriched uranium (HEU) to low-enriched uranium (LEU) fuel assemblies (FA). The FA design in MARIA is rather unique; a suitable LEU FA has never been designed or tested. IAE has contracted with CERCA (the fuel supply portion of AREVA in France) to supply 2 lead test assemblies (LTA). The LTAs will be irradiated in MARIA to burnup level of at least 40% for both LTAs and to 60% for one LTA. IAE may decide to purchase additional LEU FAs for a full core conversion after the test irradiation. The Reactor Safety Committee within IAE and the National Atomic Energy Agency in Poland (PAA) must approve the LTA irradiation process. The approval will be based, in part, on IAE submitting revisions to portions of the Safety Analysis Report (SAR) which are affected by the insertion of the LTAs. (A similar process will be required for the full core conversion to LEU fuel.) The analysis required was established during working meetings between Argonne National Laboratory (ANL) and IAE staff during August 2006, subsequent email correspondence, and subsequent staff visits. The analysis needs to consider the current high-enriched uranium (HEU) core and 4 core configurations containing 1 and 2 LEU LTAs in various core positions. Calculations have been performed at ANL in support of the LTA irradiation. These calculations are summarized in this report and include criticality, burn-up, neutronics parameters, steady-state thermal hydraulics, and postulated transients. These calculations have been performed at the request of the IAE staff, who are performing similar calculations to be used in their SAR amendment submittal to the PAA. The ANL analysis has been performed independently from that being performed by IAE and should only be used as one step in the verification process.

  5. Teaching Rhythmic Movement to Children: "Chock-Let Pie"

    ERIC Educational Resources Information Center

    Hastie, Peter A.; Martin, Ellen H.; Gibson, Gary S.

    2005-01-01

    It is doubtful that any teacher would question the value of rhythmic movement in a physical education program. The benefits of being able to move rhythmically and to keep a beat are numerous. First, children with rhythm have an increased kinesthetic awareness of their body in motion and stillness. As most physical activities have an inherent…

  6. "Cutting it" means slicing up the patient pie.

    PubMed

    Sheth, J N

    1985-01-01

    This article has attempted to demonstrate why market segmentation will become increasingly prevalent in the health care industry. It has also suggested how segmentation can be extremely useful to health care practitioners. Finally, it has described three customer characteristics (demographics, psycho-graphics, and usage patterns) as a basis for segmenting the market. Three marketing practices (competitive positioning, full line versus specialty, and payment plans) as the bases for market segmentation have also been identified.

  7. Recurrent Education: "Apple Pie" ...or..."Atomic Bomb"?

    ERIC Educational Resources Information Center

    Day, William L.

    The author conceptualizes recurrent education as organized, structured, institutionally sponsored learning activities with intentional outcomes, which are distributed over the life span of the individual in a recurring way. Some problems to which recurrent education proposes solutions include: alienation at the inter-generational level,…

  8. Can the Lung Cancer Pie Be Divided into Angiogenic Slices?

    PubMed

    Cascone, Tina; Heymach, John V

    2015-12-01

    There are no validated markers for predicting benefit from angiogenesis inhibitors or classifying tumors with distinct angiogenic phenotypes. In patients with non-small cell lung cancer treated with bevacizumab and erlotinib, Franzini and colleagues find that angiogenesis- and hypoxia-associated gene expression signatures predict tumor response and/or clinical outcome, and may define distinct angiogenic patterns.

  9. Telescopes on the Moon or pie in the sky?

    NASA Technical Reports Server (NTRS)

    Pilcher, Carl B.

    1992-01-01

    The question is examined of whether it makes sense to believe that there will one day be an interferometric array of telescopes on the Moon. The question is really one of national commitment to a lunar base, since it is not likely that a scientific undertaking of this magnitude would occur in the absence of permanent human presence on the Moon. A discussion is also given of the real possibility if the exploration of space should be a multinational effort.

  10. PIE Nacelle Flow Analysis and TCA Inlet Flow Quality Assessment

    NASA Technical Reports Server (NTRS)

    Shieh, C. F.; Arslan, Alan; Sundaran, P.; Kim, Suk; Won, Mark J.

    1999-01-01

    This presentation includes three topics: (1) Analysis of isolated boattail drag; (2) Computation of Technology Concept Airplane (TCA)-installed nacelle effects on aerodynamic performance; and (3) Assessment of TCA inlet flow quality.

  11. Networking: Pie in the Sky or Icing on the Cake?

    ERIC Educational Resources Information Center

    Spain, Tom

    1984-01-01

    Discusses benefits and pitfalls of networking or disk-sharing in computer labs where microcomputers are connected to a central disk drive which runs one program for all microcomputers at one time. Copyright and software compatibility from educators' and publishers' perspectives, costs, time factors, and educational objectives are included in the…

  12. Improving Relationships: Serving up a Slice of "Enemy Pie"

    ERIC Educational Resources Information Center

    Hall, P. Cougar; McIntyre, Emily

    2011-01-01

    The "14 Characteristics of Effective Health Education Curricula" identified by the Centers for Disease Control and Prevention, Division of Adolescent and School Health promote teaching ideas designed to personalize information and engage students through activities which are both student centered and interactive. Effective health education efforts…

  13. The Humble Pie--Half-Baked or Well Done?

    ERIC Educational Resources Information Center

    Hunt, Neville; Mashhoudy, Houshang

    2008-01-01

    This article re-examines the much maligned piechart and provides justification for its use. It identifies common pitfalls when drawing piecharts in Microsoft Excel and offers advice on how to avoid them. (Contains 6 figures and 5 tables.)

  14. Dividing up the pie: Whales, fish, and humans as competitors

    NASA Astrophysics Data System (ADS)

    Ruzicka, James J.; Steele, John H.; Ballerini, Tosca; Gaichas, Sarah K.; Ainley, David G.

    2013-09-01

    Similarly structured food web models of four coastal ecosystems (Northern California Current, Central Gulf of Alaska, Georges Bank, southwestern Antarctic Peninsula) were used to investigate competition among whales, fishes, pinnipeds, and humans. Two analysis strategies simulated the effects of historic baleen and odontocete whale abundances across all trophic levels: food web structure scenarios and time-dynamic scenarios. Direct competition between whales and commercial fisheries is small at current whale abundances; whales and fisheries each take similar proportions of annual pelagic fish production (4-7%). Scenarios show that as whale populations grow, indirect competition between whales and fish for zooplankton would more likely impact fishery production than would direct competition for fish between whales and commercial fisheries. Increased baleen whale abundance would have greater and broader indirect effects on upper trophic levels and fisheries than a similar increase in odontocete abundance. Time-dynamic scenarios, which allow for the evolution of compensatory mechanisms, showed more modest impacts than structural scenarios, which show the immediate impacts of altered energy pathways. Structural scenarios show that in terms of energy availability, there is potential for large increases in whale abundance without major changes to existing food web structures and without substantial reduction of fishery production. For each ecosystem, a five-fold increase in baleen whale abundance could be supported with minor disruptions to existing energy flow pathways. However, such an increase would remain below historical population levels for many cetaceans. A larger expansion (20X) could be accommodated only with large reductions in energy flow to competitor groups. The scope for odontocete expansion varies between ecosystems but may be more restricted than the scope for baleen expansion because they feed at higher, less productive trophic levels. Egestion: unassimilated consumption, feces; directed to detritus pools. Metabolism: basal metabolism, specific dynamic action, and activity costs in terms of ammonium excretion NH4+; directed to recycled nutrient pools. Predation: a production term; production directed to grazing or predation by other functional groups. “Other” mortality: a production term; “other” mortality is unconsumed production; principally unconsumed phytoplankton; directed to detritus pools. Export (losses): a production term; export of plankton and pelagic detritus by physical transport; export losses are handled as a reduction of group transfer efficiency (the fraction of consumption that is passed to higher trophic level groups through grazing or predation). “Consumption” for phytoplankton is the uptake of new nitrate NO3- input and recycled ammonium NH4+ produced by consumer metabolism. Nitrate input was rescaled to carbon based upon the Redfield ratio (6.625 mmole C mmole N-1) and to wet weight based upon the estimated carbon content of fish (8.8 mg wet weight mg C-1) (Steele et al., 2007).The E2E trophic network matrices for each region are provided as Supplementary material. The E2E network models for the Northern California Current (NCC), Central Gulf of Alaska (CGoA), and southwestern Antarctic Peninsula (sWAP) ecosystems were derived following the techniques of Steele and Ruzicka (2011) from solutions for biomasses, consumption rates, and predation pressure upon each functional group calculated using ECOPATH algorithms (Christensen and Walters, 2004). The NCC model was modified from Ruzicka et al. (2012), the CGoA model was modified as noted in the Supplementary material from the full Gulf of Alaska model documented in Aydin et al. (2007), and the sWAP model was modified from Ballerini et al. (submitted for publication). A quantitative assessment of the Georges Bank (GB) food web is given in Steele et al. (2007) and Collie et al. (2009). Top predators (seabirds, baleen whales, odontocetes) were implicit in the original GB model. These components have now been explicitly defined using information from Link et al. (2006) to provide estimates of the abundance, diets, and consumption rates of birds and mammals on Georges Bank. (ECOPATH parameters and diet matrices for all four regional models are provided in the Supplementary material).Each regional model was developed by a different team of researchers with different emphasis of purpose but was re-structured so that each shared similar functional group aggregations. Functional groups were aggregated using production-weighted mean values of physiological parameters and diets and the sums of group biomasses and fishery harvests. Model currencies also differed between regional models: wet weight biomass (NCC, CGoA), nitrogen biomass (GB), and carbon biomass (sWAP). However, all analyses are expressed as comparable dimensionless metrics: relative changes in production rate (E2E network scenarios) and relative changes in biomass (time-dynamic scenarios).

  15. A Howling Success: How To Put Your "Pied Dedans."

    ERIC Educational Resources Information Center

    Smillie, Barrie

    1996-01-01

    Discusses humorous incidences of translating an idiom from one language literally into another. Notes that words with a similar look or sound in English and the target language, or within the target language, cause confusion. (Author/CK)

  16. Lactobacillus sakei lipoteichoic acid inhibits MMP-1 induced by UVA in normal dermal fibroblasts of human.

    PubMed

    You, Ga-Eun; Jung, Bong-Jun; Kim, Hye-Rim; Kim, Han-Geun; Kim, Tae-Rahk; Chung, Dae-Kyun

    2013-10-28

    Human skin is continuously exposed to ultraviolet (UV)-induced photoaging. UVA increases the activity of MMP-1 in dermal fibroblasts through mitogen-activated protein kinase (MAPK), p38, signaling. The irradiation of keratinocytes by UVA results in the secretion of the inflammatory cytokine, tumor necrosis factor-α (TNF-α), and the stimulation of MMP-1 in normal human dermal fibroblasts (NHDFs). Lipoteichoic acid (LTA) is a component of the cell wall of gram-positive Lactobacillus spp. of bacteria. LTA is well known as an anti-inflammation molecule. LTA of the bacterium Lactobacillus plantarum has an anti-photoaging effect, but the potential anti-photoaging effect of the other bacteria has not been examined to date. The current study showed that L. sakei LTA (sLTA) has an immune modulating effect in human monocyte cells. Our object was whether inhibitory effects of sLTA on MMP-1 are caused from reducing the MAPK signal in NHDFs. It inhibits MMP-1 and MAPK signaling induced by UVA in NHDFs. We also confirmed effects of sLTA suppressing TNF-α inducing MMP-1 in NHDFs.

  17. Ability of Lactobacillus plantarum lipoteichoic acid to inhibit Vibrio anguillarum-induced inflammation and apoptosis in silvery pomfret (Pampus argenteus) intestinal epithelial cells.

    PubMed

    Gao, Quanxin; Gao, Qian; Min, Minghua; Zhang, Chenjie; Peng, Shiming; Shi, Zhaohong

    2016-07-01

    Lipoteichoic acid (LTA) is a major constituent of the cell wall of Gram-positive bacteria. The structure and immunomodulation of LTA vary greatly between different species. LTA from Lactobacillus plantarum has been shown to exert anti-pathogenic effects. Vibrio anguillarum is a major causative agent of vibriosis, one of the most prevalent fish diseases. The purpose of this study was to examine the effects of L. plantarum LTA on V. anguillarum growth, adhesion, and induced inflammation and apoptosis in intestinal epithelial cells of silvery pomfret (Pampus argenteus). Our results showed that L. plantarum LTA was unable to inhibit V. anguillarum growth; however, it significantly inhibited adhesion of V. anguillarum. It also showed significant inhibitory effects on EHEC-induced inflammation and apoptosis by modulating the expression of NF-κB (nuclear factor kappa B), IκB (inhibitor of NF-κB), Bcl2 (B-cell leukemia/lymphoma-2), BAX (Bcl-2-associated X protein), IL-8 (interleukin 8) and TNF-α (tumor necrosis factor-α), and via inhibition of caspase-9 and caspase-3 activation. These data extend our understanding of the beneficial effects of L. plantarum LTA, which is related to the inhibition of V. anguillarum, and suggest that L. plantarum LTA has potential as a new therapeutic agent against V. anguillarum-caused vibriosis in fish.

  18. Assembly of D-alanyl-lipoteichoic acid in Lactobacillus casei: mutants deficient in the D-alanyl ester content of this amphiphile

    SciTech Connect

    Ntamere, A.S.; Taron, D.J.; Neuhaus, F.C.

    1987-04-01

    D-Alanyl-lipoteichoic acid (D-alanyl-LTA) from Lactobacillus casei ATCC 7469 contains a poly(glycerophosphate) moiety that is acylated with D-alanyl ester residues. The physiological function of these residues is not well understood. Five mutant strains of this organism that are deficient in the esters of this amphiphile were isolated and characterized. When compared with the parent, strains AN-1 and AN-4 incorporated less than 10% of D-(/sup 14/C)alanine into LTA, whereas AN-2, AN-3, and AN-5 incorporated 50%. The synthesis of D-(/sup 14/C)alanyl-lipophilic LTA was virtually absent in the first group and was approximately 30% in the second group. The mutant strains synthesized and selected the glycolipid anchor for LTA assembly. In addition, all of the strains synthesized the poly(glycerophosphate) moiety of LTA to the same extent as did the parent or to a greater extent. It was concluded that the membranes from the mutant strains AN-1 and AN-4 are defective for D-alanylation of LTA even though acceptor LTA is present. Mutant strains AN-2 and AN-3 appear to be partially deficient in the amount of the D-alanine-activating enzyme. Aberrant morphology and defective cell separation appear to result from this deficiency in D-alanyl ester content.

  19. Preliminary Results from the iMUSH Active Source Seismic Experiment

    NASA Astrophysics Data System (ADS)

    Levander, Alan; Kiser, Eric; Palomeras, Imma; Zelt, Colin; Schmandt, Brandon; Hansen, Steve; Harder, Steven; Creagar, Kenneth; Vidale, John; Abers, Geoffrey

    2015-04-01

    iMUSH (imaging Magma Under Saint Helens) is a US NSF sponsored multi-disciplinary investigation of Mount Saint Helens (MSH), currently the most active volcano in the Cascades arc in the northwestern United States. The project consists of active and passive seismic experiments, extensive magnetotelluric sounding, and geological/geochemical studies involving scientists at 7 institutions in the U.S. and Europe. The long-term goal of the seismic project is to combine analysis of the active source data with that of data from the 70 element broadband seismograph operating from summer 2014 until 2016. Combining seismic and MT analyses with other data, we hope to image the MSH volcanic plumbing system from the surface to the subducting Juan de Fuca slab. Here we describe preliminary results of the iMUSH active source seismic experiment, conducted in July and August 2014. The active source experiment consisted of twenty-three 454 or 908 kg weight shots recorded by ~3500 seismographs deployed at ~6,000 locations. Of these instruments, ~900 Nodal Seismic instruments were deployed continuously for two weeks in an areal array within 10 km of the MSH summit. 2,500 PASSCAL Texan instruments were deployed twice for five days in 3 areal arrays and 2 dense orthogonal linear arrays that extended from MSH to distances > 80 km. Overall the data quality from the shots is excellent. The seismograph arrays also recorded dozens of micro-earthquakes beneath the MSH summit and along the MSH seismic zone, and numerous other local and regional earthquakes. In addition, at least one low frequency event beneath MSH was recorded during the experiment. At this point we have begun various types of analysis of the data set: We have determined an average 1D Vp structure from stacking short-term/long-term average ratios, we have determined the 2-D Vp structure from ray-trace inversions along the two orthogonal profiles (in the NW-SE and NE-SW directions), and we have made low-fold CMP stacks of the

  20. Comparison of laser transit anemometry data analysis techniques

    NASA Technical Reports Server (NTRS)

    Humphreys, William M., Jr.; Gartrell, Luther R.

    1991-01-01

    Two techniques for the extraction of two-dimensional flow information from laser transit anemometry (LTA) data sets are presented and compared via a simulation study and experimental investigation. The methods are a probability density function (PDF) estimation technique and a marginal distribution analysis technique. The simulation study builds on the results of previous work and provides a quantification of the accuracy of both techniques for various LTA data acquisition scenarios. The experimental comparison consists of using an LTA system to survey the flow downstream of a turbulence generator in a small low-speed wind tunnel. The collected data sets are analyzed and compared.

  1. Enterococcus faecalis lipoteichoic acid suppresses Aggregatibacter actinomycetemcomitans lipopolysaccharide-induced IL-8 expression in human periodontal ligament cells.

    PubMed

    Im, Jintaek; Baik, Jung Eun; Kim, Kyoung Whun; Kang, Seok-Seong; Jeon, Jun Ho; Park, Ok-Jin; Kim, Hyun Young; Kum, Kee-Yeon; Yun, Cheol-Heui; Han, Seung Hyun

    2015-08-01

    Periodontitis is caused by multi-bacterial infection and Aggregatibacter actinomycetemcomitans and Enterococcus faecalis are closely associated with inflammatory periodontal diseases. Although lipopolysaccharide (LPS) of A. actinomycetemcomitans (Aa.LPS) and lipoteichoic acid of E. faecalis (Ef.LTA) are considered to be major virulence factors evoking inflammatory responses, their combinatorial effect on the induction of chemokines has not been investigated. In this study, we investigated the interaction between Aa.LPS and Ef.LTA on IL-8 expression in human periodontal ligament (PDL) cells. Aa.LPS, but not Ef.LTA, substantially induced IL-8 expression at the protein and mRNA levels. Interestingly, Ef.LTA suppressed Aa.LPS-induced IL-8 expression without affecting the binding of Aa.LPS to Toll-like receptor (TLR) 4. Ef.LTA reduced Aa.LPS-induced phosphorylation of mitogen-activated protein kinases, including ERK, JNK and p38 kinase. Furthermore, Ef.LTA inhibited the Aa.LPS-induced transcriptional activities of the activating protein 1, CCAAT/enhancer-binding protein and nuclear factor-kappa B transcription factors, all of which are known to regulate IL-8 gene expression. Ef.LTA augmented the expression of IL-1 receptor-associated kinase-M (IRAK-M), a negative regulator of TLR intracellular signaling pathways, in the presence of Aa.LPS at both the mRNA and protein levels. Small interfering RNA silencing IRAK-M reversed the attenuation of Aa.LPS-induced IL-8 expression by Ef.LTA. Collectively, these results suggest that Ef.LTA down-regulates Aa.LPS-induced IL-8 expression in human PDL cells through up-regulation of the negative regulator IRAK-M.

  2. Paradoxical Results and Item Bundles

    ERIC Educational Resources Information Center

    Hooker, Giles; Finkelman, Matthew

    2010-01-01

    Hooker, Finkelman, and Schwartzman ("Psychometrika," 2009, in press) defined a paradoxical result as the attainment of a higher test score by changing answers from correct to incorrect and demonstrated that such results are unavoidable for maximum likelihood estimates in multidimensional item response theory. The potential for these results to…

  3. An Investigation of the Applicability of High Altitude, Lighter-Than-Air (LTA) Vehicles to the Tactical Communications Relay Problem

    DTIC Science & Technology

    1974-08-20

    are employed at relatively low altitudes , usually below 20, 000 ft (6. 1 kin). Although France recently flew a stratospheric tethered balloon at 55...the start those which do not appear suitable for the high-6 altitude , multi-mode communications application. 2.1 Tethered Balloon Systems The first...free balloon systemsp i and their applicability to the high altitude communications relay problem. 6. Corbin, C. D. (1974) Portable Tethered Balloon

  4. A gain-of-function mutation in oma-1, a C. elegans gene required for oocyte maturation, results in delayed degradation of maternal proteins and embryonic lethality.

    PubMed

    Lin, Rueyling

    2003-06-01

    In vertebrates, oocytes undergo maturation, arrest in metaphase II, and can then be fertilized by sperm. Fertilization initiates molecular events that lead to the activation of early embryonic development. In Caenorhabditis elegans, where no delay between oocyte maturation and fertilization is apparent, oocyte maturation and fertilization must be tightly coordinated. It is not clear what coordinates the transition from an oocyte to an embryo in C. elegans, but regulated turnover of oocyte-specific proteins contributes to the process. We describe here a gain-of-function mutation (zu405) in a gene that is essential for oocyte maturation, oma-1. In wild type animals, OMA-1 protein is expressed at a high level exclusively in oocytes and newly fertilized embryos and is degraded rapidly after the first mitotic division. The zu405 mutation results in improper degradation of the OMA-1 protein in embryos. In oma-1(zu405) embryos, the C blastomere is transformed to the EMS blastomere fate, resulting in embryonic lethality. We show that degradation of several maternally supplied cell fate determinants, including SKN-1, PIE-1, MEX-3, and MEX-5, is delayed in oma-1(zu405) mutant embryos. In wild type embryos, SKN-1 functions in EMS for EMS blastomere fate specification. A decreased level of maternal SKN-1 protein in the C blastomere relative to EMS is believed to be responsible for this cell expressing the C, instead of the EMS, fate. Delayed degradation of maternal SKN-1 protein in oma-1(zu405) embryos and resultant elevated levels in C blastomere is likely responsible for the observed C-to-EMS blastomere fate transformation. These observations suggest that oma-1, in addition to its role in oocyte maturation, contributes to early embryonic development by regulating the temporal degradation of maternal proteins in early C. elegans embryos.

  5. Misleading biochemical laboratory test results

    PubMed Central

    Nanji, Amin A.

    1984-01-01

    This article reviews the general and specific factors that interfere with the performance of common biochemical laboratory tests and the interpretation of their results. The clinical status of the patient, drug interactions, and in-vivo and in-vitro biochemical interactions and changes may alter the results obtained from biochemical analysis of blood constituents. Failure to recognize invalid laboratory test results may lead to injudicious and dangerous management of patients. PMID:6375845

  6. Detecting intervention effects using a multilevel latent transition analysis with a mixture IRT model.

    PubMed

    Cho, Sun-Joo; Cohen, Allan S; Bottge, Brian

    2013-07-01

    A multilevel latent transition analysis (LTA) with a mixture IRT measurement model (MixIRTM) is described for investigating the effectiveness of an intervention. The addition of a MixIRTM to the multilevel LTA permits consideration of both potential heterogeneity in students' response to instructional intervention as well as a methodology for assessing stage sequential change over time at both student and teacher levels. Results from an LTA-MixIRTM and multilevel LTA-MixIRTM were compared in the context of an educational intervention study. Both models were able to describe homogeneities in problem solving and transition patterns. However, ignoring a multilevel structure in LTA-MixIRTM led to different results in group membership assignment in empirical results. Results for the multilevel LTA-MixIRTM indicated that there were distinct individual differences in the different transition patterns. The students receiving the intervention treatment outscored their business as usual (i.e., control group) counterparts on the curriculum-based Fractions Computation test. In addition, 27.4 % of the students in the sample moved from the low ability student-level latent class to the high ability student-level latent class. Students were characterized differently depending on the teacher-level latent class.

  7. MER ARA pyroshock test results

    NASA Technical Reports Server (NTRS)

    Chang, Kurng Y.

    2004-01-01

    This paper presents the shock test results achieved in the MER ARA/brush motor pyroshock qualification. The results of MER flight system pyrofiring tests in comparison with the ARA shock test requirements are discussed herein. Alternate test methods were developed in an effort to qualify the critical MER equipment for adequate performance in the actual flight pyroshock condition.

  8. Latest Electroweak Results from CDF

    SciTech Connect

    Lancaster, Mark

    2010-05-01

    The latest results in electroweak physics from proton anti-proton collisions at the Fermilab Tevatron recorded by the CDF detector are presented. The results provide constraints on parton distribution functions, the mass of the Higgs boson and beyond the Standard Model physics.

  9. Top physics results at CDF

    SciTech Connect

    Vickey, Trevor; /Illinois U., Urbana

    2005-05-01

    The most recent results on top quark physics at CDF are reported. Measurements of cross-section and mass are presented, and the status of single top quark production searches are discussed. The results obtained from probing various top quark properties are also presented.

  10. Fuel and fission product behaviour in early phases of a severe accident. Part II: Interpretation of the experimental results of the PHEBUS FPT2 test

    NASA Astrophysics Data System (ADS)

    Dubourg, R.; Barrachin, M.; Ducher, R.; Gavillet, D.; De Bremaecker, A.

    2014-10-01

    One objective of the FPT2 test of the PHEBUS FP Program was to study the degradation of an irradiated UO2 fuel bundle and the fission product behaviour under conditions of low steam flow. The results of the post-irradiation examinations (PIE) at the upper levels (823 mm and 900 mm) of the test section previously reported are interpreted in the present paper. Solid state interactions between fuel and cladding have been compared with the characteristics of interaction identified in the previous separate-effect tests. Corium resulting from the interaction between fuel and cladding was formed. The uranium concentration in the corium is compared to analytical tests and a scenario for the corium formation is proposed. The analysis showed that, despite the rather low fuel burn up, the conditions of temperature and oxygen potential reached during the starvation phase are able to give an early very significant release fraction of caesium. A significant part (but not all) of the molybdenum was segregated at grain boundaries and trapped in metallic inclusions from which they were totally removed in the final part of the experiment. During the steam starvation phase, the conditions of oxygen potential were favourable for the formation of simple Ba and BaO chemical forms but the temperature was too low to provoke their volatility. This is one important difference with out-of-pile experiments such as VERCORS for which only a combination of high temperature and low oxygen potential induced a significant barium release. Finally another significant difference with analytical out-of-pile experiments comes from the formation of foamy zones due to the fission gas presence in FPT2-type experiments which give an additional possibility for the formation of stable fission product compounds.

  11. Results of Neptunium Disposal Testing

    SciTech Connect

    Walker, D.D.

    2003-10-07

    Researchers investigated the neutralization of neptunium solution from H-Canyon Tank 16.4 and the properties of the resulting slurry. This work investigated slurry properties from a single neutralization protocol and limited storage times.

  12. SMART-1/AMIE Camera Results

    NASA Astrophysics Data System (ADS)

    Josset, J.-L.; Beauvivre, S.; Cerroni, P.; de Sanctis, M. C.; Pinet, P.; Chevrel, S.; Langevin, Y.; Barucci, M. A.; Plancke, P.; Koschny, D.; Almeida, M.; Sodnik, Z.; Mancuso, S.; Hofmann, B. A.; Muinonen, K.; Shevchenko, V.; Shkuratov, Yu.; Ehrenfreund

    2007-03-01

    The Advanced Moon micro-Imager Experiment (AMIE), on board ESA SMART-1, the first European mission to the Moon, is an imaging system with scientific, technical and public outreach oriented objectives. This paper presents the first results obtained during

  13. Recent KTeV Results

    SciTech Connect

    Richard Kessler

    2001-11-09

    Preliminary KTEV results are presented based on the 1997 data set, and include an improved measurement of R({epsilon}{prime}/{epsilon}), CPT tests, and precise measurements of {tau}{sub S} and {Delta}{sub m}.

  14. Electroweak results from the tevatron

    SciTech Connect

    Wood, D.

    1997-01-01

    Electroweak results are presented from the CDF and DO experiments based on data collected in recent runs of the Fermilab Tevatron Collider. The measurements include the mass and width of the W boson, the production cross sections of the W and Z bosons, and the W charge asymmetry. Additional results come from studies of events with pairs of electroweak gauge bosons and include limits on anomalous couplings.

  15. Results from experiment PS199

    NASA Astrophysics Data System (ADS)

    Agnello, M.; Ahmidouch, A.; Arvieux, J.; Bertini, R.; Birsa, R.; Bradamante, F.; Bressan, A.; Bressani, T.; Chiavassa, E.; Torre-Colautti, S. Dalla; De Marco, N.; Faivre, J. C.; Giorgi, M.; Heer, E.; Hess, R.; Iazzi, F.; Kunne, R. A.; Lamanna, M.; Luc, C. Lechanoine-Le; Macciotta, M. P.; Martin, A.; Mascarini, C.; Masoni, A.; Minetti, B.; Musso, A.; Penzo, A.; Perrot-Kunne, F.; Piccotti, A.; Puddu, G.; Rapin, D.; Serci, S.; Schiavon, P.; Tessarotto, F.

    1993-06-01

    The aim of the experiment PS199 was to study the spin structure of the charge-exchange overlinepp → overlinenn channel at LEAR. During 1990 we collected data at several energies to measure the analyzing power Aon and the spin depolarization parameter Donon.Results for Aon at all energies and first results for Donon at 905 MeV/c incident antiproton momentum are presented.

  16. QCD results from the Tevatron

    SciTech Connect

    C. Mesropian

    2002-07-12

    The Tevatron hadron collider provides the unique opportunity to study Quantum Chromodynamics, QCD, at the highest energies. The results summarized in this talk, although representing different experimental objects, as hadronic jets and electromagnetic clusters, serve to determine the fundamental input ingredients of QCD as well as to search for new physics. The authors present results from QCD studies at the Tevatron from Run 1 data, including jet and direct photon production, and a measurement of the strong coupling constant.

  17. Analysis of EUVE Experiment Results

    NASA Technical Reports Server (NTRS)

    Horan, Stephen

    1996-01-01

    A series of tests to validate an antenna pointing concept for spin-stabilized satellites using a data relay satellite are described. These tests show that proper antenna pointing on an inertially-stabilized spacecraft can lead to significant access time through the relay satellite even without active antenna pointing. We summarize the test results, the simulations to model the effects of antenna pattern and space loss, and the expected contact times. We also show how antenna beam width affects the results.

  18. The MUNU experiment : preliminary results

    NASA Astrophysics Data System (ADS)

    Busto, J.; MUNU Collaboration

    2000-06-01

    The MUNU collaboration has built a detector to study overlineνe - e - scattering at low energy. From the results we expect to increase the sensitivity to the neutrino magnetic moment. The detector used, a 1 m 3 T.P.C. surrounded by an anti-Compton scintillator, is running at the Bugey nuclear plant. Some preliminary results will be presented in the following.

  19. CYP3A-dependent drug metabolism is reduced in bacterial inflammation in mice

    PubMed Central

    Gandhi, AS; Guo, T; Shah, P; Moorthy, B; Chow, DS-L; Hu, M; Ghose, R

    2012-01-01

    BACKGROUND AND PURPOSE Gene expression of Cyp3a11 is reduced by activation of Toll-like receptors (TLRs) by Gram-negative or Gram-positive bacterial components, LPS or lipoteichoic acid (LTA) respectively. The primary adaptor protein in the TLR signalling pathway, TIRAP, plays differential roles in LPS- and LTA-mediated down-regulations of Cyp3a11 mRNA. Here, we have determined the functional relevance of these findings by pharmacokinetic/pharmacodynamic (PK/PD) analysis of the Cyp3a substrate midazolam in mice. Midazolam is also metabolized by Cyp2c in mice. EXPERIMENTAL APPROACH Adult male C57BL/6, TIRAP+/+ and TIRAP−/− mice were pretreated with saline, LPS (2 mg·kg−1) or LTA (6 mg·kg−1). Cyp3a11 protein expression, activity and PK/PD studies using midazolam were performed. KEY RESULTS Cyp3a11 protein expression in LPS- or LTA-treated mice was reduced by 95% and 60% compared with saline-treated mice. Cyp3a11 activity was reduced by 70% in LPS- or LTA-treated mice. Plasma AUC of midazolam was increased two- to threefold in LPS- and LTA-treated mice. Plasma levels of 1′-OHMDZ decreased significantly only in LTA-treated mice. Both LPS and LTA decreased AUC of 1′-OHMDZ-glucuronide. In the PD study, sleep time was increased by ∼2-fold in LPS- and LTA-treated mice. LTA-mediated decrease in Cyp3a11 protein expression and activity was dependent on TIRAP. In PK/PD correlation, AUC of midazolam was increased only in LPS-treated mice compared with saline-treated mice. CONCLUSIONS AND IMPLICATIONS LPS or LTA altered PK/PD of midazolam. This is the first study to demonstrate mechanistic differences in regulation of metabolite formation of a clinically relevant drug by Gram-negative or Gram-positive bacterial endotoxins. PMID:22394353

  20. Systematic Review of Membrane Components of Gram-Positive Bacteria Responsible as Pyrogens for Inducing Human Monocyte/Macrophage Cytokine Release

    PubMed Central

    Rockel, Christoph; Hartung, Thomas

    2012-01-01

    Fifty years after the elucidation of lipopolysaccharides (LPS, endotoxin) as the principal structure of Gram-negative bacteria activating the human immune system, its Gram-positive counterpart is still under debate. Pyrogen tests based on the human monocyte activation have been validated for LPS detection as an alternative to the rabbit test and, increasingly, the limulus amebocyte lysate test. For full replacement, international validations with non-endotoxin pyrogens are in preparation. Following evidence-based medicine approaches, a systematic review of existing evidence as to the structural nature of the Gram-positive pyrogen was undertaken. For the three major constituents suggested, i.e., peptidoglycan, lipoteichoic acids (LTA), and bacterial lipoproteins (LP), the questions to be answered and a search strategy for relevant literature was developed, starting in MedLine. The evaluation was based on the Koch–Dale criteria for a mediator of an effect. A total of 380 articles for peptidoglycan, 391 for LP, and 285 for LTA were retrieved of which 12, 8, and 24, respectively, fulfilled inclusion criteria. The compiled data suggest that for peptidoglycan two Koch–Dale criteria are fulfilled, four for LTA, and two for bacterial LP. In conclusion, based on the best currently available evidence, LTA is the only substance that fulfills all criteria. LTA has been isolated from a large number of bacteria, results in cytokine release patterns inducible also with synthetic LTA. Reduction in bacterial cytokine induction with an inhibitor for LTA was shown. However, this systematic review cannot exclude the possibility that other stimulatory compounds complement or substitute for LTA in being the counterpart to LPS in some Gram-positive bacteria. PMID:22529809

  1. Biosynthesis, isolation, and NMR analysis of leukotriene A epoxides: substrate chirality as a determinant of the cis or trans epoxide configuration[S

    PubMed Central

    Jin, Jing; Zheng, Yuxiang; Boeglin, William E.; Brash, Alan R.

    2013-01-01

    Leukotriene (LT)A4 and closely related allylic epoxides are pivotal intermediates in lipoxygenase (LOX) pathways to bioactive lipid mediators that include the leukotrienes, lipoxins, eoxins, resolvins, and protectins. Although the structure and stereochemistry of the 5-LOX product LTA4 is established through comparison to synthetic standards, this is the exception, and none of these highly unstable epoxides has been analyzed in detail from enzymatic synthesis. Understanding of the mechanistic basis of the cis or trans epoxide configuration is also limited. To address these issues, we developed methods involving biphasic reaction conditions for the LOX-catalyzed synthesis of LTA epoxides in quantities sufficient for NMR analysis. As proof of concept, human 15-LOX-1 was shown to convert 15S-hydroperoxy-eicosatetraenoic acid (15S-HPETE) to the LTA analog 14S,15S-trans-epoxy-eicosa-5Z,8Z,10E,12E-tetraenoate, confirming the proposed structure of eoxin A4. Using this methodology we then showed that recombinant Arabidopsis AtLOX1, an arachidonate 5-LOX, converts 5S-HPETE to the trans epoxide LTA4 and converts 5R-HPETE to the cis epoxide 5-epi-LTA4, establishing substrate chirality as a determinant of the cis or trans epoxide configuration. The results are reconciled with a mechanism based on a dual role of the LOX nonheme iron in LTA epoxide biosynthesis, providing a rational basis for understanding the stereochemistry of LTA epoxide intermediates in LOX-catalyzed transformations. PMID:23242647

  2. TCIQ: An identification by intensity and frequency of potent testing cues in science

    NASA Astrophysics Data System (ADS)

    Kermis, William J.

    Everyone experiences some anxiety while taking an examination. High-test-anxious (HTA) and low-test-anxious (LTA) students are described by two characteristic differences: frequency and intensity of anxious responses and attentional direction to testing cues. The purposes of this study were threefold: (1) to report potent testing cues (i.e., 90% response agreement for both intensity and frequency) that were identified by HTA and LTA students; (2) to report differences between HTA and LTA students for frequencies and intensities of responses to testing cues; and (3) to report differences between HTA and LTA students of attentional direction to testing cues. A pool of 396 males and females who were enrolled in physical geology completed the State-Trait Anxiety Inventory. A random sample consisting of 93 HTA and 40 LTA subjects completed the Test Cues Identification Questionnaire (TCIQ). The TCIQ consists of 28 disruptive items and 27 helpful items. Subjects responded with both frequency and intensity ratings for all of the 55 items in the TCIQ. Results revealed that 22 items were viewed by subjects as potent testing cues. Empirical evidence obtained did not support previous theoretical reports of differences between HTA and LTA students for either frequency and intensity of anxious responses or attentional direction to the set of disruptive and helpful testing cues. Although test anxiousness did not appear to be associated with those two characteristics differences, a discriminant analysis revealed 24 items in the TCIQ which significantly, 2 (24) = 47.59, p < 0.004, separated HTA and LTA subjects responses. Apparently, HTA and LTA students differ in their responses to specific disruptive and helpful cues but not in their responses to the set of testing cues as was previously postulated.

  3. Planck 2015 results. I. Overview of products and scientific results

    NASA Astrophysics Data System (ADS)

    Planck Collaboration; Adam, R.; Ade, P. A. R.; Aghanim, N.; Akrami, Y.; Alves, M. I. R.; Argüeso, F.; Arnaud, M.; Arroja, F.; Ashdown, M.; Aumont, J.; Baccigalupi, C.; Ballardini, M.; Banday, A. J.; Barreiro, R. B.; Bartlett, J. G.; Bartolo, N.; Basak, S.; Battaglia, P.; Battaner, E.; Battye, R.; Benabed, K.; Benoît, A.; Benoit-Lévy, A.; Bernard, J.-P.; Bersanelli, M.; Bertincourt, B.; Bielewicz, P.; Bikmaev, I.; Bock, J. J.; Böhringer, H.; Bonaldi, A.; Bonavera, L.; Bond, J. R.; Borrill, J.; Bouchet, F. R.; Boulanger, F.; Bucher, M.; Burenin, R.; Burigana, C.; Butler, R. C.; Calabrese, E.; Cardoso, J.-F.; Carvalho, P.; Casaponsa, B.; Castex, G.; Catalano, A.; Challinor, A.; Chamballu, A.; Chary, R.-R.; Chiang, H. C.; Chluba, J.; Chon, G.; Christensen, P. R.; Church, S.; Clemens, M.; Clements, D. L.; Colombi, S.; Colombo, L. P. L.; Combet, C.; Comis, B.; Contreras, D.; Couchot, F.; Coulais, A.; Crill, B. P.; Cruz, M.; Curto, A.; Cuttaia, F.; Danese, L.; Davies, R. D.; Davis, R. J.; de Bernardis, P.; de Rosa, A.; de Zotti, G.; Delabrouille, J.; Delouis, J.-M.; Désert, F.-X.; Di Valentino, E.; Dickinson, C.; Diego, J. M.; Dolag, K.; Dole, H.; Donzelli, S.; Doré, O.; Douspis, M.; Ducout, A.; Dunkley, J.; Dupac, X.; Efstathiou, G.; Eisenhardt, P. R. M.; Elsner, F.; Enßlin, T. A.; Eriksen, H. K.; Falgarone, E.; Fantaye, Y.; Farhang, M.; Feeney, S.; Fergusson, J.; Fernandez-Cobos, R.; Feroz, F.; Finelli, F.; Florido, E.; Forni, O.; Frailis, M.; Fraisse, A. A.; Franceschet, C.; Franceschi, E.; Frejsel, A.; Frolov, A.; Galeotta, S.; Galli, S.; Ganga, K.; Gauthier, C.; Génova-Santos, R. T.; Gerbino, M.; Ghosh, T.; Giard, M.; Giraud-Héraud, Y.; Giusarma, E.; Gjerløw, E.; González-Nuevo, J.; Górski, K. M.; Grainge, K. J. B.; Gratton, S.; Gregorio, A.; Gruppuso, A.; Gudmundsson, J. E.; Hamann, J.; Handley, W.; Hansen, F. K.; Hanson, D.; Harrison, D. L.; Heavens, A.; Helou, G.; Henrot-Versillé, S.; Hernández-Monteagudo, C.; Herranz, D.; Hildebrandt, S. R.; Hivon, E.; Hobson, M.; Holmes, W. A.; Hornstrup, A.; Hovest, W.; Huang, Z.; Huffenberger, K. M.; Hurier, G.; Ilić, S.; Jaffe, A. H.; Jaffe, T. R.; Jin, T.; Jones, W. C.; Juvela, M.; Karakci, A.; Keihänen, E.; Keskitalo, R.; Khamitov, I.; Kiiveri, K.; Kim, J.; Kisner, T. S.; Kneissl, R.; Knoche, J.; Knox, L.; Krachmalnicoff, N.; Kunz, M.; Kurki-Suonio, H.; Lacasa, F.; Lagache, G.; Lähteenmäki, A.; Lamarre, J.-M.; Langer, M.; Lasenby, A.; Lattanzi, M.; Lawrence, C. R.; Le Jeune, M.; Leahy, J. P.; Lellouch, E.; Leonardi, R.; León-Tavares, J.; Lesgourgues, J.; Levrier, F.; Lewis, A.; Liguori, M.; Lilje, P. B.; Lilley, M.; Linden-Vørnle, M.; Lindholm, V.; Liu, H.; López-Caniego, M.; Lubin, P. M.; Ma, Y.-Z.; Macías-Pérez, J. F.; Maggio, G.; Maino, D.; Mak, D. S. Y.; Mandolesi, N.; Mangilli, A.; Marchini, A.; Marcos-Caballero, A.; Marinucci, D.; Maris, M.; Marshall, D. J.; Martin, P. G.; Martinelli, M.; Martínez-González, E.; Masi, S.; Matarrese, S.; Mazzotta, P.; McEwen, J. D.; McGehee, P.; Mei, S.; Meinhold, P. R.; Melchiorri, A.; Melin, J.-B.; Mendes, L.; Mennella, A.; Migliaccio, M.; Mikkelsen, K.; Millea, M.; Mitra, S.; Miville-Deschênes, M.-A.; Molinari, D.; Moneti, A.; Montier, L.; Moreno, R.; Morgante, G.; Mortlock, D.; Moss, A.; Mottet, S.; Münchmeyer, M.; Munshi, D.; Murphy, J. A.; Narimani, A.; Naselsky, P.; Nastasi, A.; Nati, F.; Natoli, P.; Negrello, M.; Netterfield, C. B.; Nørgaard-Nielsen, H. U.; Noviello, F.; Novikov, D.; Novikov, I.; Olamaie, M.; Oppermann, N.; Orlando, E.; Oxborrow, C. A.; Paci, F.; Pagano, L.; Pajot, F.; Paladini, R.; Pandolfi, S.; Paoletti, D.; Partridge, B.; Pasian, F.; Patanchon, G.; Pearson, T. J.; Peel, M.; Peiris, H. V.; Pelkonen, V.-M.; Perdereau, O.; Perotto, L.; Perrott, Y. C.; Perrotta, F.; Pettorino, V.; Piacentini, F.; Piat, M.; Pierpaoli, E.; Pietrobon, D.; Plaszczynski, S.; Pogosyan, D.; Pointecouteau, E.; Polenta, G.; Popa, L.; Pratt, G. W.; Prézeau, G.; Prunet, S.; Puget, J.-L.; Rachen, J. P.; Racine, B.; Reach, W. T.; Rebolo, R.; Reinecke, M.; Remazeilles, M.; Renault, C.; Renzi, A.; Ristorcelli, I.; Rocha, G.; Roman, M.; Romelli, E.; Rosset, C.; Rossetti, M.; Rotti, A.; Roudier, G.; Rouillé d'Orfeuil, B.; Rowan-Robinson, M.; Rubiño-Martín, J. A.; Ruiz-Granados, B.; Rumsey, C.; Rusholme, B.; Said, N.; Salvatelli, V.; Salvati, L.; Sandri, M.; Sanghera, H. S.; Santos, D.; Saunders, R. D. E.; Sauvé, A.; Savelainen, M.; Savini, G.; Schaefer, B. M.; Schammel, M. P.; Scott, D.; Seiffert, M. D.; Serra, P.; Shellard, E. P. S.; Shimwell, T. W.; Shiraishi, M.; Smith, K.; Souradeep, T.; Spencer, L. D.; Spinelli, M.; Stanford, S. A.; Stern, D.; Stolyarov, V.; Stompor, R.; Strong, A. W.; Sudiwala, R.; Sunyaev, R.; Sutter, P.; Sutton, D.; Suur-Uski, A.-S.; Sygnet, J.-F.; Tauber, J. A.; Tavagnacco, D.; Terenzi, L.; Texier, D.; Toffolatti, L.; Tomasi, M.; Tornikoski, M.; Tramonte, D.; Tristram, M.; Troja, A.; Trombetti, T.; Tucci, M.; Tuovinen, J.; Türler, M.; Umana, G.; Valenziano, L.; Valiviita, J.; Van Tent, F.; Vassallo, T.; Vibert, L.; Vidal, M.; Viel, M.; Vielva, P.; Villa, F.; Wade, L. A.; Walter, B.; Wandelt, B. D.; Watson, R.; Wehus, I. K.; Welikala, N.; Weller, J.; White, M.; White, S. D. M.; Wilkinson, A.; Yvon, D.; Zacchei, A.; Zibin, J. P.; Zonca, A.

    2016-09-01

    The European Space Agency's Planck satellite, which is dedicated to studying the early Universe and its subsequent evolution, was launched on 14 May 2009. It scanned the microwave and submillimetre sky continuously between 12 August 2009 and 23 October 2013. In February 2015, ESA and the Planck Collaboration released the second set of cosmology products based ondata from the entire Planck mission, including both temperature and polarization, along with a set of scientific and technical papers and a web-based explanatory supplement. This paper gives an overview of the main characteristics of the data and the data products in the release, as well as the associated cosmological and astrophysical science results and papers. The data products include maps of the cosmic microwave background (CMB), the thermal Sunyaev-Zeldovich effect, diffuse foregrounds in temperature and polarization, catalogues of compact Galactic and extragalactic sources (including separate catalogues of Sunyaev-Zeldovich clusters and Galactic cold clumps), and extensive simulations of signals and noise used in assessing uncertainties and the performance of the analysis methods. The likelihood code used to assess cosmological models against the Planck data is described, along with a CMB lensing likelihood. Scientific results include cosmological parameters derived from CMB power spectra, gravitational lensing, and cluster counts, as well as constraints on inflation, non-Gaussianity, primordial magnetic fields, dark energy, and modified gravity, and new results on low-frequency Galactic foregrounds.

  4. Planck 2013 results. I. Overview of products and scientific results

    NASA Astrophysics Data System (ADS)

    Planck Collaboration; Ade, P. A. R.; Aghanim, N.; Alves, M. I. R.; Armitage-Caplan, C.; Arnaud, M.; Ashdown, M.; Atrio-Barandela, F.; Aumont, J.; Aussel, H.; Baccigalupi, C.; Banday, A. J.; Barreiro, R. B.; Barrena, R.; Bartelmann, M.; Bartlett, J. G.; Bartolo, N.; Basak, S.; Battaner, E.; Battye, R.; Benabed, K.; Benoît, A.; Benoit-Lévy, A.; Bernard, J.-P.; Bersanelli, M.; Bertincourt, B.; Bethermin, M.; Bielewicz, P.; Bikmaev, I.; Blanchard, A.; Bobin, J.; Bock, J. J.; Böhringer, H.; Bonaldi, A.; Bonavera, L.; Bond, J. R.; Borrill, J.; Bouchet, F. R.; Boulanger, F.; Bourdin, H.; Bowyer, J. W.; Bridges, M.; Brown, M. L.; Bucher, M.; Burenin, R.; Burigana, C.; Butler, R. C.; Calabrese, E.; Cappellini, B.; Cardoso, J.-F.; Carr, R.; Carvalho, P.; Casale, M.; Castex, G.; Catalano, A.; Challinor, A.; Chamballu, A.; Chary, R.-R.; Chen, X.; Chiang, H. C.; Chiang, L.-Y.; Chon, G.; Christensen, P. R.; Churazov, E.; Church, S.; Clemens, M.; Clements, D. L.; Colombi, S.; Colombo, L. P. L.; Combet, C.; Comis, B.; Couchot, F.; Coulais, A.; Crill, B. P.; Cruz, M.; Curto, A.; Cuttaia, F.; Da Silva, A.; Dahle, H.; Danese, L.; Davies, R. D.; Davis, R. J.; de Bernardis, P.; de Rosa, A.; de Zotti, G.; Déchelette, T.; Delabrouille, J.; Delouis, J.-M.; Démoclès, J.; Désert, F.-X.; Dick, J.; Dickinson, C.; Diego, J. M.; Dolag, K.; Dole, H.; Donzelli, S.; Doré, O.; Douspis, M.; Ducout, A.; Dunkley, J.; Dupac, X.; Efstathiou, G.; Elsner, F.; Enßlin, T. A.; Eriksen, H. K.; Fabre, O.; Falgarone, E.; Falvella, M. C.; Fantaye, Y.; Fergusson, J.; Filliard, C.; Finelli, F.; Flores-Cacho, I.; Foley, S.; Forni, O.; Fosalba, P.; Frailis, M.; Fraisse, A. A.; Franceschi, E.; Freschi, M.; Fromenteau, S.; Frommert, M.; Gaier, T. C.; Galeotta, S.; Gallegos, J.; Galli, S.; Gandolfo, B.; Ganga, K.; Gauthier, C.; Génova-Santos, R. T.; Ghosh, T.; Giard, M.; Giardino, G.; Gilfanov, M.; Girard, D.; Giraud-Héraud, Y.; Gjerløw, E.; González-Nuevo, J.; Górski, K. M.; Gratton, S.; Gregorio, A.; Gruppuso, A.; Gudmundsson, J. E.; Haissinski, J.; Hamann, J.; Hansen, F. K.; Hansen, M.; Hanson, D.; Harrison, D. L.; Heavens, A.; Helou, G.; Hempel, A.; Henrot-Versillé, S.; Hernández-Monteagudo, C.; Herranz, D.; Hildebrandt, S. R.; Hivon, E.; Ho, S.; Hobson, M.; Holmes, W. A.; Hornstrup, A.; Hou, Z.; Hovest, W.; Huey, G.; Huffenberger, K. M.; Hurier, G.; Ilić, S.; Jaffe, A. H.; Jaffe, T. R.; Jasche, J.; Jewell, J.; Jones, W. C.; Juvela, M.; Kalberla, P.; Kangaslahti, P.; Keihänen, E.; Kerp, J.; Keskitalo, R.; Khamitov, I.; Kiiveri, K.; Kim, J.; Kisner, T. S.; Kneissl, R.; Knoche, J.; Knox, L.; Kunz, M.; Kurki-Suonio, H.; Lacasa, F.; Lagache, G.; Lähteenmäki, A.; Lamarre, J.-M.; Langer, M.; Lasenby, A.; Lattanzi, M.; Laureijs, R. J.; Lavabre, A.; Lawrence, C. R.; Le Jeune, M.; Leach, S.; Leahy, J. P.; Leonardi, R.; León-Tavares, J.; Leroy, C.; Lesgourgues, J.; Lewis, A.; Li, C.; Liddle, A.; Liguori, M.; Lilje, P. B.; Linden-Vørnle, M.; Lindholm, V.; López-Caniego, M.; Lowe, S.; Lubin, P. M.; Macías-Pérez, J. F.; MacTavish, C. J.; Maffei, B.; Maggio, G.; Maino, D.; Mandolesi, N.; Mangilli, A.; Marcos-Caballero, A.; Marinucci, D.; Maris, M.; Marleau, F.; Marshall, D. J.; Martin, P. G.; Martínez-González, E.; Masi, S.; Massardi, M.; Matarrese, S.; Matsumura, T.; Matthai, F.; Maurin, L.; Mazzotta, P.; McDonald, A.; McEwen, J. D.; McGehee, P.; Mei, S.; Meinhold, P. R.; Melchiorri, A.; Melin, J.-B.; Mendes, L.; Menegoni, E.; Mennella, A.; Migliaccio, M.; Mikkelsen, K.; Millea, M.; Miniscalco, R.; Mitra, S.; Miville-Deschênes, M.-A.; Molinari, D.; Moneti, A.; Montier, L.; Morgante, G.; Morisset, N.; Mortlock, D.; Moss, A.; Munshi, D.; Murphy, J. A.; Naselsky, P.; Nati, F.; Natoli, P.; Negrello, M.; Nesvadba, N. P. H.; Netterfield, C. B.; Nørgaard-Nielsen, H. U.; North, C.; Noviello, F.; Novikov, D.; Novikov, I.; O'Dwyer, I. J.; Orieux, F.; Osborne, S.; O'Sullivan, C.; Oxborrow, C. A.; Paci, F.; Pagano, L.; Pajot, F.; Paladini, R.; Pandolfi, S.; Paoletti, D.; Partridge, B.; Pasian, F.; Patanchon, G.; Paykari, P.; Pearson, D.; Pearson, T. J.; Peel, M.; Peiris, H. V.; Perdereau, O.; Perotto, L.; Perrotta, F.; Pettorino, V.; Piacentini, F.; Piat, M.; Pierpaoli, E.; Pietrobon, D.; Plaszczynski, S.; Platania, P.; Pogosyan, D.; Pointecouteau, E.; Polenta, G.; Ponthieu, N.; Popa, L.; Poutanen, T.; Pratt, G. W.; Prézeau, G.; Prunet, S.; Puget, J.-L.; Pullen, A. R.; Rachen, J. P.; Racine, B.; Rahlin, A.; Räth, C.; Reach, W. T.; Rebolo, R.; Reinecke, M.; Remazeilles, M.; Renault, C.; Renzi, A.; Riazuelo, A.; Ricciardi, S.; Riller, T.; Ringeval, C.; Ristorcelli, I.; Robbers, G.; Rocha, G.; Roman, M.; Rosset, C.; Rossetti, M.; Roudier, G.; Rowan-Robinson, M.; Rubiño-Martín, J. A.; Ruiz-Granados, B.; Rusholme, B.; Salerno, E.; Sandri, M.; Sanselme, L.; Santos, D.; Savelainen, M.; Savini, G.; Schaefer, B. M.; Schiavon, F.; Scott, D.; Seiffert, M. D.; Serra, P.; Shellard, E. P. S.; Smith, K.; Smoot, G. F.; Souradeep, T.; Spencer, L. D.; Starck, J.-L.; Stolyarov, V.; Stompor, R.; Sudiwala, R.; Sunyaev, R.; Sureau, F.; Sutter, P.; Sutton, D.; Suur-Uski, A.-S.; Sygnet, J.-F.; Tauber, J. A.; Tavagnacco, D.; Taylor, D.; Terenzi, L.; Texier, D.; Toffolatti, L.; Tomasi, M.; Torre, J.-P.; Tristram, M.; Tucci, M.; Tuovinen, J.; Türler, M.; Tuttlebee, M.; Umana, G.; Valenziano, L.; Valiviita, J.; Van Tent, B.; Varis, J.; Vibert, L.; Viel, M.; Vielva, P.; Villa, F.; Vittorio, N.; Wade, L. A.; Wandelt, B. D.; Watson, C.; Watson, R.; Wehus, I. K.; Welikala, N.; Weller, J.; White, M.; White, S. D. M.; Wilkinson, A.; Winkel, B.; Xia, J.-Q.; Yvon, D.; Zacchei, A.; Zibin, J. P.; Zonca, A.

    2014-11-01

    The European Space Agency's Planck satellite, dedicated to studying the early Universe and its subsequent evolution, was launched 14 May 2009 and has been scanning the microwave and submillimetre sky continuously since 12 August 2009. In March 2013, ESA and the Planck Collaboration released the initial cosmology products based on the first 15.5 months of Planck data, along with a set of scientific and technical papers and a web-based explanatory supplement. This paper gives an overview of the mission and its performance, the processing, analysis, and characteristics of the data, the scientific results, and the science data products and papers in the release. The science products include maps of the cosmic microwave background (CMB) and diffuse extragalactic foregrounds, a catalogue of compact Galactic and extragalactic sources, and a list of sources detected through the Sunyaev-Zeldovich effect. The likelihood code used to assess cosmological models against the Planck data and a lensing likelihood are described. Scientific results include robust support for the standard six-parameter ΛCDM model of cosmology and improved measurements of its parameters, including a highly significant deviation from scale invariance of the primordial power spectrum. The Planck values for these parameters and others derived from them are significantly different from those previously determined. Several large-scale anomalies in the temperature distribution of the CMB, first detected by WMAP, are confirmed with higher confidence. Planck sets new limits on the number and mass of neutrinos, and has measured gravitational lensing of CMB anisotropies at greater than 25σ. Planck finds no evidence for non-Gaussianity in the CMB. Planck's results agree well with results from the measurements of baryon acoustic oscillations. Planck finds a lower Hubble constant than found in some more local measures. Some tension is also present between the amplitude of matter fluctuations (σ8) derived from

  5. Data Mining Citizen Science Results

    NASA Astrophysics Data System (ADS)

    Borne, K. D.

    2012-12-01

    Scientific discovery from big data is enabled through multiple channels, including data mining (through the application of machine learning algorithms) and human computation (commonly implemented through citizen science tasks). We will describe the results of new data mining experiments on the results from citizen science activities. Discovering patterns, trends, and anomalies in data are among the powerful contributions of citizen science. Establishing scientific algorithms that can subsequently re-discover the same types of patterns, trends, and anomalies in automatic data processing pipelines will ultimately result from the transformation of those human algorithms into computer algorithms, which can then be applied to much larger data collections. Scientific discovery from big data is thus greatly amplified through the marriage of data mining with citizen science.

  6. New NAS Parallel Benchmarks Results

    NASA Technical Reports Server (NTRS)

    Yarrow, Maurice; Saphir, William; VanderWijngaart, Rob; Woo, Alex; Kutler, Paul (Technical Monitor)

    1997-01-01

    NPB2 (NAS (NASA Advanced Supercomputing) Parallel Benchmarks 2) is an implementation, based on Fortran and the MPI (message passing interface) message passing standard, of the original NAS Parallel Benchmark specifications. NPB2 programs are run with little or no tuning, in contrast to NPB vendor implementations, which are highly optimized for specific architectures. NPB2 results complement, rather than replace, NPB results. Because they have not been optimized by vendors, NPB2 implementations approximate the performance a typical user can expect for a portable parallel program on distributed memory parallel computers. Together these results provide an insightful comparison of the real-world performance of high-performance computers. New NPB2 features: New implementation (CG), new workstation class problem sizes, new serial sample versions, more performance statistics.

  7. KC-135 winglet flight results

    NASA Technical Reports Server (NTRS)

    Montoya, L. C.

    1981-01-01

    Three KC-135 winglet configurations were flight tested for cant/incidence angles of 15 deg/-4 deg, 15 deg/-2 deg, and 0 deg/-4 deg, as well as the basic wing. The flight results for the 15 deg/-4 deg and basic wing configurations confirm the wind tunnel predicted 7% incremental decrease in total drag at cruise conditions. The 15 deg/-4 configuration flight measured wing and winglet pressure distributions, loads, stability and control, flutter, and buffet also correlate well with predicted values. The only unexpected flight results as compared with analytical predictions is a flutter speed decrease for the 0 deg/-4 deg configuration. The 15 deg/-2 deg configuration results show essentially the same incremental drag reduction as the 15 deg/-4 deg configuration; however, the flight loads are approximately 30% higher for the 15 deg/-2 deg configuration. The drag data for the 0 deg/-4 deg configuration show only a flight drag reduction.

  8. New results from FRECOPA analysis

    NASA Technical Reports Server (NTRS)

    Durin, Christian

    1993-01-01

    New results from the ongoing analysis of the FRECOPA's (FREnch COoperative PAssive payload) system hardware are discussed. FRECOPA (AO138) was one of the 57 experiments flown on the LDEF satellite. The experiment was located on the trailing edge (Tray B3) and was exposed to UV radiation (11,100 equivalent sun hours), approximately equal to 34,000 thermal cycles, higher vacuum levels than the leading edge, a low atomic oxygen flux, and minor doses of protons and electrons. Due to LDEF's extended mission (5.8 years), CNES decided to set up a team to analyze the FRECOPA system. Initial results were presented at the First Post-Retrieval Conference, June, 1991. The results obtained since then are summarized.

  9. Catastrophic disruption experiments: Recent results

    NASA Technical Reports Server (NTRS)

    Martelli, G.; Ryan, E. V.; Nakamura, A. M.; Giblin, I.

    1994-01-01

    This paper presents a review of the progress in the field of catastrophic disruption experiments over the past 4 years, since the publication of the review paper by Fujiwara et al. (1989). We describe the development of new techniques to produce shattering impacts relevant to the study of the collisional evolution of the asteroids, and summarize the results from numerous experiments which have been performed to date, using a variety of materials for both the impactor and the targets. Some of these, such as ice-on-ice, loose aggregates and pressurized targets, are quite new and have provided novel and exciting results. Some of the gaps existing previously in the data on fragment ejection-angle distributions, as well as translational and rotational velocity fields (including fine fragments) have been filled, and these new results will be surveyed.

  10. ACTS: Technology Description and Results

    NASA Technical Reports Server (NTRS)

    Gedney, Richard T.; Schertler, Ronald; Gargione, Frank

    2000-01-01

    The ACTS Project was originated at NASA Glenn Research Center in the early 1980's to sponsor the development and application of technology that was intended to be used by the private sector. The program was formulated with the underlying philosophy of maintaining US leadership in satellite communications while focusing technology development for efficient use of the frequency spectrum. This report chronicles the execution and results of the program from the perspective of its technology managers, from inception through hardware and system development to on-orbit experiments and demonstrations of the technology. The first eight sections of the report discuss programmatic background, the specific satellite and ground terminal technology and the results generated by the program including industry relevance. A federally funded program of this type attracted strong advocates and adversaries and the resulting impact on the project schedule is also discussed. The last two sections are a list of useful acronyms and extensive references.

  11. Supersymmetry results at the Tevatron

    SciTech Connect

    Manca, Giulia; /Liverpool U.

    2005-05-01

    The Run II physics programme of the Tevatron is proceeding with more than 300 pb{sup -1} of analysis quality data, collected at a center-of-mass energy of 1.96 TeV. Searches for supersymmetric particles are starting to set new limits, improving over the LEP and Run I results and exploring new regions of parameter space. They present recent results in Supersymmetry with the upgraded CDF and D0 detectors and give some prospects for the future of these searches.

  12. Improved non-approximability results

    SciTech Connect

    Bellare, M.; Sudan, M.

    1994-12-31

    We indicate strong non-approximability factors for central problems: N{sup 1/4} for Max Clique; N{sup 1/10} for Chromatic Number; and 66/65 for Max 3SAT. Underlying the Max Clique result is a proof system in which the verifier examines only three {open_quotes}free bits{close_quotes} to attain an error of 1/2. Underlying the Chromatic Number result is a reduction from Max Clique which is more efficient than previous ones.

  13. Tau physics results from SLD

    SciTech Connect

    Daoudi, M.; SLD Collaboration

    1996-08-10

    Results on {tau} physics at SLD are presented. They are based on 4,316 {tau}-pair events selected from a 150 k Z{sup 0} data sample collected at the SLC. These results include measurements of the {tau} lifetime ({tau}{sub r} = 288.1 {+-} 6.1 {+-} 3.3 fs), the {tau} Michel parameters ({rho} = 0.71 {+-} 0.09 {+-} 0.04, {zeta} = 1.03 {+-} 0.36 {+-} 0.05, and {zeta}{delta} = 0.84 {+-} 0.27 {+-} 0.05), and the {tau} neutrino helicity (h{sub {nu}} = {minus}0.81 {+-} 0.18 {+-} 0.03).

  14. First results from SAGE II

    SciTech Connect

    Abdurashitov, J.N.; Faizov, E.L.; Gavrin, V.N.

    1994-07-01

    The Russian-American Gallium solar neutrino Experiment (SAGE) began the second phase of operation (SAGE II) in September of 1992. Monthly measurements of the integral flux of solar neutrinos have been made with 55 tonnes of gallium. The K-peak results of the first five runs of SAGE II give a capture rate of 76{sub {minus}18}{sup +21} (stat) {sub {minus}7}{sup +5} (sys) SNU. combined with the SAGE I result, the capture rate is 74{sub {minus}12}{sup +13} (stat) {sub {minus}7}{sup +5} (sys) SNU. This represents only 56%--60% of the capture rate predicted by different Standard Solar Models.

  15. Results from Numerical General Relativity

    NASA Technical Reports Server (NTRS)

    Baker, John G.

    2011-01-01

    For several years numerical simulations have been revealing the details of general relativity's predictions for the dynamical interactions of merging black holes. I will review what has been learned of the rich phenomenology of these mergers and the resulting gravitational wave signatures. These wave forms provide a potentially observable record of the powerful astronomical events, a central target of gravitational wave astronomy. Asymmetric radiation can produce a thrust on the system which may accelerate the single black hole resulting from the merger to high relative velocity.

  16. Spectroscopic commissioning results from MINERVA

    NASA Astrophysics Data System (ADS)

    Eastman, Jason D.; Johnson, Samson; Wang, Sharon; Sliski, David; Wilson, Maurice; Johnson, John A.; McCrady, Nate; Wittenmyer, Robert A.; Wright, Jason; Plavchan, Peter; Blake, Cullen; Beatty, Thomas G.

    2017-01-01

    MINERVA is a robotic observatory with four 0.7 meter telescopes at Mt. Hopkins, Arizona, dedicated to precise photometry and radial velocity observations of bright, nearby stars for the discovery and characterization of small exoplanets. Here we present the first radial velocity results from MINERVA during commissioning at the Fred Lawrence Whipple Observatory in Arizona, demonstrating m/s precision over month-long timescales. These results show that MINERVA is capable of achieving its primary science goal of finding super-Earths around the nearest, brightest stars.

  17. MC-1 Nozzle Testing Results

    NASA Technical Reports Server (NTRS)

    Peters, Warren; Turner, James E. (Technical Monitor)

    2000-01-01

    This document is the presentation graphics which reviews the test results of the MC-1 Nozzle. The MC-1 Nozzle was originally designed for a low cost engine for an expendable booster. It was modified for use in the X-34 propulsion plant. With this design the nozzle and chamber are one piece. The presentation reviews the design goals, the materials and fabrication. The tests and results are reviewed in considerable detail. Included are pictures of the nozzle, and diagrams of the nozzle geometry

  18. Recent results from hadron colliders

    SciTech Connect

    Frisch, H.J. )

    1990-12-10

    This is a summary of some of the many recent results from the CERN and Fermilab colliders, presented for an audience of nuclear, medium-energy, and elementary particle physicists. The topics are jets and QCD at very high energies, precision measurements of electroweak parameters, the remarkably heavy top quark, and new results on the detection of the large flux of B mesons produced at these machines. A summary and some comments on the bright prospects for the future of hadron colliders conclude the talk. 39 refs., 44 figs., 3 tabs.

  19. Photometric commissioning results from MINERVA

    NASA Astrophysics Data System (ADS)

    Eastman, Jason D.; Swift, Jonathan; Beatty, Thomas G.; Bottom, Michael; Johnson, John; Wright, Jason; McCrady, Nate; Wittenmyer, Robert A.; Riddle, Reed L.; Plavchan, Peter; Muirhead, Philip Steven; Blake, Cullen; Zhao, Ming

    2015-01-01

    MINERVA is a robotic observatory with four 0.7 meter telescopes at Mt. Hopkins, Arizona, dedicated to precise photometry and radial velocity observations of bright, nearby stars for the discovery and characterization of small exoplanets. Here we present the first photometric results from MINERVA during commissioning at our test facility in Pasadena, California, demonstrating sub-millimag precision on 3-5 minute timescales over several hours. These results show that MINERVA is well-equipped to address its secondary science goal of searching for transits of known and newly discovered super-Earth exoplanets detected by radial velocity, including potential detections from the MINERVA spectrograph.

  20. CDF results on electroweak physics

    SciTech Connect

    Frisch, H.J.; CDF Collaboration

    1993-11-01

    The second major run of the {bar p}p Fermilab Tevatron collider has just ended on June 1. The CDF detector has accumulated almost five times the data sample of its previous 1988--1989 run. We present new results on the ratio of W to Z boson production cross-sections and on the charge asymmetry in W decay. We give a progress report on the measurement of the W mass. New results from the 1988--1989 data on Drell-Yan production and on W {gamma} production are also presented.

  1. Ensemble Clustering for Result Diversification

    DTIC Science & Technology

    2012-11-01

    different clustering methods for a par- ticular data source. He et al. [8] proposed a framework to combine clusters of external resources to...representations for result diversification. In Proceedings of SIGIR, 2012. [9] D. Hiemstra and C. Hauff. Mapreduce for information retrieval evaluation: ‘let’s

  2. Recent Results from Hera Collider

    NASA Astrophysics Data System (ADS)

    Levonian, Sergey

    2013-11-01

    HERA collaborations H1 and ZEUS are publishing final analyses based on complete e±p statistics of ~ 0.5 fb-1 per experiment and using combinations of their data sets. Here selected recent results are presented from three areas: structure of the proton, searches for new physics and investigations of QCD phenomena at low Bjorken x.

  3. Results of Computer Based Training.

    ERIC Educational Resources Information Center

    1978

    This report compares the projected savings of using computer based training to conduct training for newly hired pilots to the results of that application. New Hire training, one of a number of programs conducted continuously at the United Airline Flight Operations Training Center, is designed to assure that any newly hired pilot will be able to…

  4. Perseids 2006 results in Romania

    NASA Astrophysics Data System (ADS)

    Grigore, Valentin; Berinde, Stefan; Conu, Alexandru

    2007-12-01

    The results of 14th edition of the Perseide (Perseid) project organized by SARM are presented. PERSEIDE 2006 - the national astronomical camp for yought had two distinct parts: a summer astronomical school and a national Perseid network. Over 60 persons attended this event which lasted for four weeks and had both a training and observing component.

  5. HADES results in elementary reactions

    NASA Astrophysics Data System (ADS)

    Ramstein, B.; Adamczewski-Musch, J.; Arnold, O.; Atomssa, E. T.; Behnke, C.; Berger-Chen, J. C.; Biernat, J.; Blanco, A.; Blume, C.; Böhmer, M.; Bordalo, P.; Chernenko, S.; Deveaux, C.; Dybczak, A.; Epple, E.; Fabbietti, L.; Fateev, O.; Fonte, P.; Franco, C.; Friese, J.; Fröhlich, I.; Galatyuk, T.; Garzón, J. A.; Gill, K.; Golubeva, M.; Guber, F.; Gumberidze, M.; Harabasz, S.; Hennino, T.; Hlavac, S.; Höhne, C.; Holzmann, R.; Ierusalimov, A.; Ivashkin, A.; Jurkovic, M.; Kämpfer, B.; Karavicheva, T.; Kardan, K.; Koenig, I.; Koenig, W.; Kolb, B. W.; Korcyl, G.; Kornakov, G.; Kotte, R.; Krása, A.; Krebs, E.; Kuc, H.; Kugler, A.; Kunz, T.; Kurepin, A.; Kurilkin, A.; Kurilkin, P.; Ladygin, V.; Lalik, R.; Lapidus, K.; Lebedev, A.; Lopes, L.; Lorenz, M.; Mahmoud, T.; Maier, L.; Mangiarotti, A.; Markert, J.; Metag, V.; Michel, J.; Müntz, C.; Münzer, R.; Naumann, L.; Palka, M.; Parpottas, Y.; Pechenov, V.; Pechenova, O.; Petousis, V.; Pietraszko, J.; Przygoda, W.; Rehnisch, L.; Reshetin, A.; Rost, A.; Rustamov, A.; Sadovsky, A.; Salabura, P.; Scheib, T.; Schmidt-Sommerfeld, K.; Schuldes, H.; Sellheim, P.; Siebenson, J.; Silva, L.; Sobolev, Yu. G.; Spataro, S.; Ströbele, H.; Stroth, J.; Strzempek, P.; Sturm, C.; Svoboda, O.; Tarantola, A.; Teilab, K.; Tlusty, P.; Traxler, M.; Tsertos, H.; Vasiliev, T.; Wagner, V.; Wendisch, C.; Wirth, J.; Wüstenfeld, J.; Zanevsky, Y.; Zumbruch, P.

    2014-11-01

    Recent results obtained with the HADES experimental set-up at GSI are presented with a focus on dielectron production and strangeness in pp and quasi-free np reactions. Perspectives related to the very recent experiment using the pion beam at GSI are also discussed.

  6. Diffractive physics results at CDF

    SciTech Connect

    Michele Gallinaro

    2003-12-18

    Forward detectors are described together with the first physics results from Run II. Using new data and dedicated diffractive triggers, a measurement of single diffractive dijet production rate, with particular focus on the diffractive structure function of the antiproton, is discussed. Upper limits on the exclusive dijet and {chi}{sub c}{sup 0} production cross sections are also presented.

  7. The Planck Mission: Early Results

    SciTech Connect

    Marco Bersanelli

    2012-03-07

    The ESA Planck space mission, launched on May 14, 2009, is dedicated to high precision measurements of the cosmic microwave background (CMB), the first light of the universe, both in temperature and polarization. The satellite observes the full sky from a far-Earth orbit with two cryogenic instruments in the 30-850 GHz range at the focal plane of a 1.5-meter telescope. The primary objective of Planck is to measure with unprecedented precision the key cosmological parameters and to provide accurate tests of physics in the early universe. Planck has recently completed the fifth full-sky survey. The data analysis is underway. The first cosmology results are expected in early 2013 while a number of astrophysical results have been recently delivered to the community, including galactic and extragalactic astrophysics and a rich catalogue of radio and infrared sources. These results demonstrate the excellent in-orbit performance of the instruments and give excellent prospects for the forthcoming cosmological results.

  8. FFTF startup: status and results

    SciTech Connect

    Noordhoff, B.H.; Moore, C.E.

    1980-03-01

    Startup testing on the Fast Flux Test Facility (FFTF) during the past three years has progressed beyond initial criticality toward the principal goal of power demonstration in 1980. An overview is presented of technical results to date and project plans to achieve power demonstration and complete the startup test program.

  9. Cuesta College School Performance Results.

    ERIC Educational Resources Information Center

    Cuesta Coll., San Luis Obispo, CA.

    This Cuesta College (California) document identifies key institutional effectiveness indicators that are used to assess institutional performance on specified educational processes. The key process of instruction/learning is measured through student performance results such as: (1) transfer rate (University of California/California State…

  10. Recent Results from the Tevatron

    SciTech Connect

    Demorden, L.

    1998-06-01

    We review recent results from fixed-target and collider experiments at the Fermilab Tevatron. Among the topics discussed are jet production rates, {alpha}{sub S} measurements, the {anti d}/{anti u} ratio in the proton sea, diffraction, heavy quark physics and leptoquark searches.

  11. Light Transmission Aggregometry Does Not Correlate With the Severity of δ-Granule Platelet Storage Pool Deficiency.

    PubMed

    Woods, Gary M; Kudron, Elizabeth L; Davis, Kyle; Stanek, Joseph; Kerlin, Bryce A; O'Brien, Sarah H

    2016-10-01

    Delta-granule platelet storage pool deficiency (δ-PSPD) is a poorly studied bleeding diathesis resulting from either decreased granule content or decreased average number of platelet δ-granules. Light transmission aggregometry (LTA) is commonly used to evaluate for δ-PSPD and platelet electron microscopy (EM) is used to confirm the diagnosis. Currently, little data exist examining the relationship between the likelihood of abnormal platelet aggregation findings, severity of δ-granule deficiency on platelet EM, and severity of bleeding symptoms in patients with δ-PSPD. Patients diagnosed with δ-PSPD by platelet EM who also underwent LTA testing were identified at a single institution for correlation between severity of bleeding, average number of platelet δ-granules, and number of agonist abnormalities on LTA. No statistically significant association was identified between the average number of δ-granules per platelet and likelihood of an abnormal LTA. LTA abnormalities were quite varied and only 50% diagnosed with δ-PSPD on EM had abnormal aggregation testing. Also, no correlation was seen between the number of clinical bleeding symptoms, number of average δ-granules per platelet, and the number of LTA agonist abnormalities. Our findings highlight the difficulties inherent in the laboratory evaluation of platelet function.

  12. Systematic Review of Surgical Approaches for Adrenal Tumors: Lateral Transperitoneal versus Posterior Retroperitoneal and Laparoscopic versus Robotic Adrenalectomy

    PubMed Central

    Chai, Young Jun; Kwon, Hyungju; Yu, Hyeong Won; Kim, Su-jin; Choi, June Young; Lee, Kyu Eun; Youn, Yeo-Kyu

    2014-01-01

    Background. Laparoscopic lateral transperitoneal adrenalectomy (LTA) has been the standard method for resecting benign adrenal gland tumors. Recently, however, laparoscopic posterior retroperitoneal adrenalectomy (PRA) has been more popular as an alternative method. This systematic review evaluates current evidence on adrenalectomy techniques, comparing laparoscopic LTA with PRA and laparoscopic adrenalectomy with robotic adrenalectomy. Methods. PubMed, Embase, and ISI Web of Knowledge databases were searched systematically for studies comparing surgical outcomes of laparoscopic LTA versus PRA and laparoscopic versus robotic adrenalectomy. The studies were evaluated according to the PRISMA statement. Results. Eight studies comparing laparoscopic PRA and LTA showed that laparoscopic PRA was superior or at least comparable to laparoscopic LTA in operation time, blood loss, pain score, hospital stay, and return to normal activity. Conversion rates and complication rates were similar. Six studies comparing robotic and laparoscopic adrenalectomy found that outcomes and complications were similar. Conclusion. Laparoscopic PRA was more effective than LTA, especially in reducing operation time and hospital stay, but there was no evidence showing that robotic adrenalectomy was superior to laparoscopic adrenalectomy. Cost reductions and further technical advances are needed for wider application of robotic adrenalectomy. PMID:25587275

  13. Surveyor 3 Preliminary Science Results

    NASA Technical Reports Server (NTRS)

    1967-01-01

    Surveyor III soft-landed on the Moon at 00:04 GMT on April 20, 1967. Data obtained have significantly increased our knowledge of the Moon. The Surveyor III spacecraft was similar to Surveyor I; the only major change in scientific instrumentation was the addition of a soil mechanics surface sampler. Surveyor III results at this preliminary evaluation of data give valuable information about the relation between the surface skin of under-dense material responsible for the photometric properties and the deeper layers of material whose properties resemble those of ordinary terrestrial soils. In addition, they provide new insight into the relation between the general lunar surface as seen by Surveyor I and the interior of a large subdued crater. The new results have also contributed to our understanding of the mechanism of downhill transport. Many critical questions cannot, however, be answered until final reduction of experimental data.

  14. Forget about data, deliver results

    NASA Astrophysics Data System (ADS)

    Walter, Roland

    2015-12-01

    High-energy astrophysics space missions have pioneered and demonstrated the power of legacy data sets for generating new discoveries, especially when analysed in ways original researchers could not have anticipated. The only way to ensure that the data of present observatories can be effectively used in the future is to allow users to perform on-the-fly data analysis to produce straightforwardly scientific results for any sky position, time and energy intervals without requiring mission specific software or detailed instrumental knowledge. Providing a straightforward interface to complex data and data analysis makes the data and the process of generating science results available to the public and higher education and promotes the visibility of the investment in science to the society. This is a fundamental step to transmit the values of science and to evolve towards a knowledge society.

  15. CMS results on multijet correlations

    SciTech Connect

    Safronov, Grigory

    2015-04-10

    We present recent CMS measurements on multijet correlations using forward and low-p{sub T} jets, focusing on searches for BFKL and saturation phenomena. In pp collisions at √(s)=7 TeV, azimuthal correlations in dijets separated in rapidity by up to 9.4 units were measured. The results are compared to BFKL- and DGLAP-based predictions. In pp collisions at √(s)=8 TeV, cross sections for jets with p{sub T} > 21 GeV and |y| < 4.7, and for track-jets with p{sub T} > 1 GeV (minijets) are presented. The minijet results are sensitive to the bound imposed by the total inelastic cross section, and are compared to various models for taming the growth of the 2 → 2 cross section at low p{sub T}.

  16. Seeds in space experiment results

    NASA Technical Reports Server (NTRS)

    Alston, Jim A.

    1991-01-01

    Two million seeds of 120 different varieties representing 106 species, 97 genera, and 55 plant families were flown aboard the Long Duration Exposure Facility (LDEF). The seeds were housed on the space exposed experiment developed for students (SEEDS) tray in sealed canister number six and in two small vented canisters. The tray was in the F-2 position. The seeds were germinated and the germination rates and development of the resulting plants compared to the control seed that stayed in Park Seed's seed storage facility. The initial results are presented. There was a better survival rate in the sealed canister in space than in the storage facility at Park Seed. At least some of the seeds in each of the vented canisters survived the exposure to vacuum for almost six years. The number of observed apparent mutations was very low.

  17. Top physics results from CDF

    SciTech Connect

    Gomez, Gervasio; /Cantabria Inst. of Phys.

    2005-05-01

    The top quark is by far the most massive fundamental particle observed so far, and the study of its properties is interesting for several reasons ranging from its possible special role in electroweak symmetry breaking to its sensitivity to physics beyond the Standard Model. They present recent top physics results from CDF based on 160-320 pb{sup -1} of p{bar p} collision data at {radical}s = 1.96 TeV. The t{bar t} cross section and the top mass have been measured in different decay channels and using different methods. they have searched for evidence of single top production, setting upper limits on its production rate. Other results shown in this conference include studies of the polarization of W bosons from top decays, a search for charged Higgs decaying from top, and a search for additional heavy t' quarks.

  18. Recent DIII-D results

    SciTech Connect

    Petersen, P.I.

    1994-07-01

    This paper summarizes the recent DIII-D experimental results and the development of the relevant hardware systems. The DIII-D program focuses on divertor solutions for next generation tokamaks such as International Thermo-nuclear Experimental Reactor (ITER) and Tokamak Physics Experiment (TPX), and on developing configurations with enhanced confinement and stability properties that will lead to a more compact and economical fusion reactor. The DIII-D program carries out this research in an integrated fashion.

  19. Cassini Imaging Results at Titan

    NASA Technical Reports Server (NTRS)

    McEwen, A.; Turtle, E.; Perry J.; Fussner, S.; Porco, C.; West, R.; Johnson, T.; Collins, G.; DelGenio, T.; Barbara, J.

    2005-01-01

    The Cassini Imaging Science Subsystem (ISS) images show striking albedo markings on the surface of Titan. In equatorial regions the albedo patterns have high contrast and exhibit prominent lineaments and linear/angular boundaries suggestive of tectonic influences or fracturing of brittle surficial materials. There are intriguing dark curving lines near the south pole. Here we present several working hypotheses to explain these patterns. We also briefly summarize atmospheric science results.

  20. Overview of recent ALICE results

    NASA Astrophysics Data System (ADS)

    Lakomov, Igor

    2016-10-01

    ALICE is one of the four largest LHC experiments. It is dedicated to the study of the properties of the deconfined state of matter formed at large energy densities in heavy-ion collisions — the Quark-Gluon Plasma. The ALICE Collaboration also participated in the pp and p-Pb data-taking periods at the LHC. An overview of recent ALICE results is presented for three collision systems: pp, p-Pb and Pb-Pb.

  1. Electroweak results from D0

    SciTech Connect

    Demarteau, M.; D0 Collaboration

    1993-05-01

    Preliminary results from D0 are presented on properties of the W{sup {plus_minus}} and Z{sup 0} electroweak gauge bosons, using final states containing electrons and muons. In particular, preliminary measurements of the W{sup {plus_minus}} and Z{sup 0} production cross sections with decay into final states containing electrons are shown and a status report on the determination of M{sub w}/M{sub z} is given.

  2. B0s Oscillation Results

    SciTech Connect

    Willocq, Stephane

    2002-08-09

    The authors review new studies of the time dependence of B{sub s}{sup 0}-{bar B}{sub s}{sup 0} mixing by the ALEPH, DELPHI and SLD Collaborations, with an emphasis on the different analysis methods used. Combining all available results yields a preliminary lower limit on the oscillation frequency of {Delta}m{sub s} > 14.4 ps{sup -1} at the 95% C.L.

  3. SPQR -- Spectroscopy: Prospects, Questions & Results

    SciTech Connect

    Pennington, Michael R.

    2014-06-01

    Tremendous progress has been made in mapping out the spectrum of hadrons over the past decade with plans to make further advances in the decade ahead. Baryons and mesons, both expected and unexpected, have been found, the results of precision experiments often with polarized beams, polarized targets and sometimes polarization of the final states. All these hadrons generate poles in the complex energy plane that are consequences of strong coupling QCD. They reveal how this works.

  4. Top quark results at CDF

    SciTech Connect

    Leone, S.; CDF Collaboration

    1996-08-01

    We present the latest results on the top quark obtained by the CDF experiment using a data sample of about 110 {ital pb}{sup -1} collected at the Fermilab Tevatron collider. We briefly describe the candidate events selection and then discuss the production cross section determination and the mass measurement. The study of two new decay channels (all hadronic and ``tau dilepton``) is also reported.

  5. Recent results from Daya Bay

    NASA Astrophysics Data System (ADS)

    Chua, Ming-chung

    2016-11-01

    Utilizing powerful nuclear reactors as antineutrino sources, high mountains to provide ample shielding from cosmic rays in the vicinity, and functionally identical detectors with large target volume for near-far relative measurement, the Daya Bay Reactor Neutrino Experiment has achieved unprecedented precision in measuring the neutrino mixing angle θ13 and the neutrino mass squared difference |Δm2ee|. I will report the latest Daya Bay results on neutrino oscillations and light sterile neutrino search.

  6. [Results of routine intraoperative cholangiography].

    PubMed

    Klima, S; Schyra, B

    1999-01-01

    Most bile duct injuries result from an incorrect interpretation of bile duct anatomy. In 500 laparoscopic cholecystectomies we used a modified technique of cholecystcholangiography. This method is very easy and needs only 5 minutes. We found variants of bile duct anatomy in 74 cases and occult bile duct stones in 20 patients. We recommend this method which decreases the risk of bile duct injuries and gives the opportunity to approximate the golden standard of conventional cholecystectomy.

  7. Open cherry picker simulation results

    NASA Technical Reports Server (NTRS)

    Nathan, C. A.

    1982-01-01

    The simulation program associated with a key piece of support equipment to be used to service satellites directly from the Shuttle is assessed. The Open Cherry Picker (OCP) is a manned platform mounted at the end of the remote manipulator system (RMS) and is used to enhance extra vehicular activities (EVA). The results of simulations performed on the Grumman Large Amplitude Space Simulator (LASS) and at the JSC Water Immersion Facility are summarized.

  8. Results from the B Factories

    SciTech Connect

    Bevan, A.; /Queen Mary, U. of London

    2009-01-08

    These proceedings are based on lectures given at the Helmholtz International Summer School Heavy Quark Physics at the Bogoliubov Laboratory of Theoretical Physics, Dubna, Russia, during August 2008. I review the current status of CP violation in B meson decays from the B factories. These results can be used, along with measurements of the sides of the Unitarity Triangle, to test the CKM mechanism. In addition I discuss experimental studies of B decays to final states with 'spin-one' particles.

  9. Digital coincidence counting - initial results

    NASA Astrophysics Data System (ADS)

    Butcher, K. S. A.; Watt, G. C.; Alexiev, D.; van der Gaast, H.; Davies, J.; Mo, Li; Wyllie, H. A.; Keightley, J. D.; Smith, D.; Woods, M. J.

    2000-08-01

    Digital Coincidence Counting (DCC) is a new technique in radiation metrology, based on the older method of analogue coincidence counting. It has been developed by the Australian Nuclear Science and Technology Organisation (ANSTO), in collaboration with the National Physical Laboratory (NPL) of the United Kingdom, as a faster more reliable means of determining the activity of ionising radiation samples. The technique employs a dual channel analogue-to-digital converter acquisition system for collecting pulse information from a 4π beta detector and an NaI(Tl) gamma detector. The digitised pulse information is stored on a high-speed hard disk and timing information for both channels is also stored. The data may subsequently be recalled and analysed using software-based algorithms. In this letter we describe some recent results obtained with the new acquistion hardware being tested at ANSTO. The system is fully operational and is now in routine use. Results for 60Co and 22Na radiation activity calibrations are presented, initial results with 153Sm are also briefly mentioned.

  10. PACOSS program status and results

    NASA Technical Reports Server (NTRS)

    Richards, K. E., Jr.

    1989-01-01

    Future large space systems (LSS), both civilian and military, will have performance objectives which require stringent pointing accuracies, relatively fast retargeting times, short settling times, accurate dynamic shape requirements, or combinations thereof. Many of these structures will be large but lightweight and will exhibit a dense, low-frequency modal spectrum with significant content within the control bandwidth. Although it is possible in principle to achieve structural vibration control with purely active means, experience with complex structures has shown that the realities of plant model inaccuracies and real sensor and actuator dynamics frequently combine to produce disappointing results. It was shown that a combination of passive and active control will result in a simpler system which can be expected to be more reliable and less expensive than a corresponding system utilizing active control exclusively. The goals of the Passive and Active Control of Space Structures (PACOSS) program consist of a thorough investigation of the relative roles of passive active vibration control, and the development of validated means of vibration control. The program approach, representative system article, dynamic test article, and test status and results are outlined.

  11. ISO: highlights of recent results

    NASA Astrophysics Data System (ADS)

    Metcalfe, L.; Salama, A.

    ESA's Infrared Space Observatory (ISO) mission, operating in the wavelength range from 2.5 to 240 microns, made over 26000 scientific observations during its 2.5 year operational lifetime. ISO's results broke new ground on all scales. New asteroid counts and improved asteroid thermophysical models augmented important advances in Solar System chemistry to comprise a striking body of results addressing our planetary system. In turn, parallels between the chemical composition of Solar System dust and dust around other stars revealed by the comparison of stellar spectra with cometary spectra, together with results on the incidence and stability of stellar disks, recall the birth of our Solar System and point to fundamental similarities with other star systems. Numerous important facts concerning the chemistry of the ISM have unfolded, such as the ubiquity of water and of the probably-organic carriers of the Unidentified Infrared Bands (UIBs). The large systematic body of data on galactic stars has permitted fascinating advances in the characterisation of important aspects of stellar evolution. Investigations of nearby normal galaxies complement template specimens of interacting galaxies. These in turn exemplify galaxy evolutionary processes in the early Universe associated with a huge burst of dust-obscured star formation at redshifts of just below one. This global surge of star formation has vital implications for the interpretation and explanation of major components of the Extragalactic Background Light (EBL) and for charting the global history of star formation and the relative importance of sources which derive their energy from accretion processes. Representative examples of key aspects of ISO's recent scientific output will be presented, once again affirming ISO's place at the forefront of successful space-borne astronomy missions.

  12. Results from the HARP Experiment

    SciTech Connect

    Catanesi, M. G.

    2008-02-21

    Hadron production is a key ingredient in many aspects of {nu} physics. Precise prediction of atmospheric {nu} fluxes, characterization of accelerator {nu} beams, quantification of {pi} production and capture for {nu}-factory designs, all of these would profit from hadron production measurements. HARP at the CERN PS was the first hadron production experiment designed on purpose to match all these requirements. It combines a large, full phase space acceptance with low systematic errors and high statistics. HARP was operated in the range from 3 GeV to 15 GeV. We briefly describe here the most recent results.

  13. Lightcurve Results for Eleven Asteroids

    NASA Astrophysics Data System (ADS)

    Gartrelle, Gordon M.

    2012-04-01

    Differential photometry techniques were used to develop lightcurves, rotation periods and amplitudes for eleven main-belt asteroids: 833 Monica, 962 Aslog, 1020 Arcadia, 1082 Pirola, 1097 Vicia, 1122 Lugduna, 1145 Robelmonte, 1253 Frisia, 1256 Normannia, 1525 Savolinna, and 2324 Janice. Ground-based observations from Badlands Observatory (BLO) in Quinn, SD, as well as the University of North Dakota Observatory (UND) in Grand Forks, ND, provided the data for the project. A search of the asteroid lightcurve database (LCDB) did not reveal any previously reported results for seven of the eleven targets in this study.

  14. Some Recent Results with CLAS

    SciTech Connect

    Maurik Holtrop

    2010-10-01

    The CLAS is a multipurpose, large acceptance magnetic spectrometer, instrumented with detector systems sensitive to charged and neutral particles. The experimental program at CLAS is aimed at furthering our understanding of hadronic and nuclear physics, through electron and photon scattering experiments, which cover a large range of topics, including meson and baryon spectroscopy, nucleon structure through elastic and deep inelastic scattering, nuclear transparency, nuclear correlations and nuclear structure. This talk will briefly describe the detector and the collaboration that uses it and will highlight some recent results.

  15. Results from the EDGES Survey

    NASA Astrophysics Data System (ADS)

    van Zee, Liese; EDGES Team

    2017-03-01

    Results are presented from a deep imaging survey with the Spitzer Space Telescope which was designed to identify and measure the faint stellar populations around nearby galaxies. The Extended Disk Galaxy Exploration Science (EDGES) Survey includes a sample of 92 nearby galaxies with a range of morphological types and environments. The observations include a field-of-view of at least 5 times the optical size and are deep enough to detect stellar mass surface densities of several hundredths of a solar mass per square parsec. The observations reveal extended stellar features, such as stellar disks and stellar streams, around many of the target galaxies, as expected from hierarchical galaxy formation scenarios.

  16. Results from the MSSTA III

    NASA Astrophysics Data System (ADS)

    Boerner, P. F. X.; Martinez-Galarce, D. S.; Bay, T. J.; Barbee, T. W.; Talasaz, A. A.; Kumar, R.; Jain, P.; Hakim, N.

    2002-12-01

    The Multi-Spectral Solar Telescope Array was launched on April 30th, 2002 on a Terrier-boosted Black Brant at White Sands Missile Range. It used an array of multilayer-coated Ritchey-Chretien telescopes to image the solar corona at 150 Å, 171 Å, 180 Å, 195 Å and 211 Å. High-resolution chromospheric spectroheliograms at 1216 Å and 1550 Å were also obtained. We present the results of the mission and report on the status of the image calibration, as well as early analysis of active region loops using MSSTA data.

  17. RSG Deployment Case Testing Results

    SciTech Connect

    Owsley, Stanley L.; Dodson, Michael G.; Hatchell, Brian K.; Seim, Thomas A.; Alexander, David L.; Hawthorne, Woodrow T.

    2005-09-01

    The RSG deployment case design is centered on taking the RSG system and producing a transport case that houses the RSG in a safe and controlled manner for transport. The transport case was driven by two conflicting constraints, first that the case be as light as possible, and second that it meet a stringent list of Military Specified requirements. The design team worked to extract every bit of weight from the design while striving to meet the rigorous Mil-Spec constraints. In the end compromises were made primarily on the specification side to control the overall weight of the transport case. This report outlines the case testing results.

  18. Recent QCD results from CDF

    SciTech Connect

    I. Gorelov

    2001-12-28

    Experimental results on QCD measurements obtained in recent analyses and based on data collected with CDF Detector from the Run 1b Tevatron running cycle are presented. The scope of the talk includes major QCD topics: a measurement of the strong coupling constant {alpha}{sub s}, extracted from inclusive jet spectra and the underlying event energy contribution to a jet cone. Another experimental object of QCD interest, prompt photon production, is also discussed and the updated measurements by CDF of the inclusive photon cross section at 630 GeV and 1800 GeV, and the comparison with NLO QCD predictions is presented.

  19. Overview of recent ALICE results

    NASA Astrophysics Data System (ADS)

    Gunji, Taku

    2016-12-01

    The ALICE experiment explores the properties of strongly interacting QCD matter at extremely high temperatures created in Pb-Pb collisions at LHC and provides further insight into small-system physics in (high-multiplicity) pp and p-Pb collisions. The ALICE collaboration presented 27 parallel talks, 50 posters, and 1 flash talk at Quark Matter 2015 and covered various topics including collective dynamics, correlations and fluctuations, heavy flavors, quarkonia, jets and high pT hadrons, electromagnetic probes, small system physics, and the upgrade program. This paper highlights some of the selected results.

  20. Electroweak results from the Tevatron

    SciTech Connect

    Demarteau, M.

    1995-10-01

    Results from the CDF and D{O} experiments are presented on properties of the W{plus_minus} and Z{sup 0} gauge bosons using final states containing electrons and muons based on large integrated luminosities. In particular, measurements of the W{plus_minus} and Z{sup 0} production cross sections, the W-charge asymmetry and the CDF measurement of the W-mass are summarized. Gauge boson self interactions axe measured by studying di-gauge boson production and limits on anomalous gauge boson couplings axe discussed.

  1. APS undulator radiation: First results

    SciTech Connect

    Cai, Z.; Dejus, R.J.; Hartog, P.D.

    1995-12-31

    The first undulator radiation has been extracted from the Advanced Photon Source (APS). The results from the characterization of this radiation are very satisfactory. With the undulator set at a gap of 15.8 mm (K=1.61), harmonics as high as the 17th were observed using a crystal spectrometer. The angular distribution of the third-harmonic radiation was measured, and the source was imaged using a zone plate to determine the particle beam emittance. The horizontal beam emittance was found to be 6.9 {plus_minus} 1.0 nm-rad, and the vertical emittance coupling was found to be less than 3%. The absolute spectral flux was measured over a wide range of photon energies, and it agrees remarkably well with the theoretical calculations based on the measured undulator magnetic field profile and the measured beam emittance. These results indicate that both the emittance of the electron beam and the undulator magnetic field quality exceed the original specifications.

  2. Unfavourable results in thumb reconstruction

    PubMed Central

    Kumta, Samir M.

    2013-01-01

    The history of thumb reconstruction parallels the history of hand surgery. The attributes that make the thumb unique, and that the reconstructive surgeon must assess and try to restore when reconstructing a thumb, are: Position, stability, strength, length, motion, sensibility and appearance. Deficiency in any of these attributes can reduce the utility of the reconstructed thumb. A detailed assessment of the patient and his requirements needs to be performed before embarking on a thumb reconstruction. Most unsatisfactory results can be attributed to wrong choice of procedure. Component defects of the thumb are commonly treated by tissue from adjacent fingers, hand or forearm. With refinements in microsurgery, the foot has become a major source of tissue for component replacement in the thumb. Bone lengthening, osteoplastic reconstruction, pollicisation, and toe to hand transfers are the commonest methods of thumb reconstruction. Unfavourable results can be classified as functional and aesthetic. Some are common to all types of procedures. However each type of reconstruction has its own unique set of problems. Meticulous planning and execution is essential to give an aesthetic and functionally useful thumb. Secondary surgeries like tendon transfers, bone grafting, debulking, arthrodesis, may be required to correct deficiencies in the reconstruction. Attention needs to be paid to the donor site as well. PMID:24501466

  3. Latest results from Double Chooz

    NASA Astrophysics Data System (ADS)

    Minotti, A.

    2017-01-01

    Double Chooz is a short-baseline neutrino disappearance experiment. It detects ν¯ e produced in the power plant of Chooz, France, where is located. The main goal of the experiment is the measurement of θ13 mixing angle and in 2011 for the first time the experiment observed an indication for a non zero value of such an oscillation parameter. The mixing angle was successively measured using only the far detector finding the best fit value of sin2(2θ13) = 0.090 -0.029 +0.032 . The near detector is under construction and will start data taking by the middle of 2014 allowing the reduction of the systematic errors. In this paper I make a review of the Double Chooz experiment, focusing in particular on the latest results of the measurement of the mixing angle θ13 relying on the neutron absorption on Gadolinium. I also present results proving the capability of Double Chooz to identify the ortho-positronium. This has been done in an event-by-event basis for the first time in a large liquid scintillator experiments, and can be an additional handle for the electron/positron discrimination in future detectors based on such technology.

  4. REMS Wind Sensor Preliminary Results

    NASA Astrophysics Data System (ADS)

    De La Torre Juarez, M.; Gomez-Elvira, J.; Navarro, S.; Marin, M.; Torres, J.; Rafkin, S. C.; Newman, C. E.; Pla-García, J.

    2015-12-01

    The REMS instrument is part of the Mars Science Laboratory payload. It is a sensor suite distributed over several parts of the rover. The wind sensor, which is composed of two booms equipped with a set of hot plate anemometers, is installed on the Rover Sensing Mast (RSM). During landing most of the hot plates of one boom were damaged, most likely by the pebbles lifted by the Sky Crane thruster. The loss of one wind boom necessitated a full review of the data processing strategy. Different algorithms have been tested on the readings of the first Mars year, and these results are now archived in the Planetary Data System (PDS), The presentation will include a description of the data processing methods and of the resulting products, including the typical evolution of wind speed and direction session-by-session, hour-by-hour and other kinds of statistics . A review of the wind readings over the first Mars year will also be presented.

  5. Wave results from OEDIPUS A

    NASA Astrophysics Data System (ADS)

    James, H. G.

    1993-10-01

    Active wave experiments in the 0-5 MHz range were carried out using a synchronized transmitter-receiver pair on the tethered sounding rocket payload OEDIPUS A. At full tether extension, the transmitter-receiver separation was 958 m. Although the transmitter power was modest (2.5 W), the receiver recorded strong propagation in tether-guided sheath-wave and plane-wave electromagnetic modes. After a summary of two principal wave results from the OEDIPUS experiment, these results are compared with related phenomena from the topside sounder spacecraft. The sheath-wave spectra clearly suggest that sheath waves are damped by electrostatic cyclotron waves. This is consistent with ideas in the topside-sounder literature that discuss how electrostatic waves transfer energy to the surrounding plasma. The transmission efficiency of slow Z-mode plane waves between the plasma and upper-hybrid resonance frequencies depends on guiding by density irregularities, which have produced related signatures in the monostatic sounder records.

  6. Seismic monitoring of Poland - temporary seismic project - first results

    NASA Astrophysics Data System (ADS)

    Trojanowski, J.; Plesiewicz, B.; Wiszniowski, J.; Suchcicki, J.; Tokarz, A.

    2012-04-01

    The aim of the project is to develop national database of seismic activity for seismic hazard assessment. Poland is known as a region of very low seismicity, however some earthquakes occur from time to time. The historical catalogue consists of less than one hundred earthquakes in the time span of almost one thousand years. Due to such a low occurrence rate, the study has been focussing on events at magnitudes lower than 2 which are more likely to occur during a few-year-long project. There are 24 mobile seismic stations involved in the project which are deployed in temporary locations close to humans neighbourhood. It causes a high level of noise and disturbances in recorded seismic signal. Moreover, the majority of Polish territory is covered by a thick sediments. It causes the problem of a reliable detection method for small seismic events in noisy data. The majority of algorithms is based on the concept of STA/LTA ratio and is designed for strong teleseismic events registered on many stations. Unfortunately they fail on the problem of weak events in the signal with noise and disturbances. It has been decided to apply Real Time Recurrent Neural Network (RTRN) to detect small natural seismic events from Poland. This method is able to assess relations of seismic signal in frequency domains as well as in time of seismic phases. The RTRN was taught by wide range of seismic signals - regional, teleseismic as well as blasts. The method is routinely used to analyse data from the project. In the firs two years of the project the seismic network was set in southern Poland, where relatively large seismicity in known. Since the mid-2010 the stations have been working in several regions of central and northern Poland where some minor historical earthquakes occurred. Over one hundred seismic events in magnitude range from 0.5 to 2.3 confirms the activity of Podhale region (Tatra Mountains, Carpathians), where an earthquake of magnitude 4.3 occurred in 2004. Initially three

  7. Airfreight forecasting methodology and results

    NASA Technical Reports Server (NTRS)

    1978-01-01

    A series of econometric behavioral equations was developed to explain and forecast the evolution of airfreight traffic demand for the total U.S. domestic airfreight system, the total U.S. international airfreight system, and the total scheduled international cargo traffic carried by the top 44 foreign airlines. The basic explanatory variables used in these macromodels were the real gross national products of the countries involved and a measure of relative transportation costs. The results of the econometric analysis reveal that the models explain more than 99 percent of the historical evolution of freight traffic. The long term traffic forecasts generated with these models are based on scenarios of the likely economic outlook in the United States and 31 major foreign countries.

  8. First year results from LOTIS

    NASA Astrophysics Data System (ADS)

    Williams, G. G.; Parks, H. S.; Ables, E.

    1997-11-01

    LOTIS (Livermore Optical Transient Imaging System) is a gamma-ray burst optical couterpart search experiment located near Lawrence Livermore National Laboratory in California. The system is linked to the GCN (GRB Coordinates Network) real-time coordinate distribution network and can respond to a burst trigger in 6-15 seconds. LOTIS has a total field-of-view of 17.4 degrees x 17.4 degrees with a completeness sensitivity of mv approximately 11 for a 10 second integration time. Since operations began in October 1996, LOTIS has responded to over 30 GCN/BATSE GRB triggers. Seven of these triggers are considered good events subject to the criteria of clear weather conditions, (lt) 60 S RESPONSE TIME, AND (gt)50% coverage of the final BATSE 3(sigma) error circle. We discuss results from the first year of LOTIS operations with an emphasis on the observations and analysis of GRB 971006 (BATSE trigger 6414) .

  9. Data Assimilation Results from PLASMON

    NASA Astrophysics Data System (ADS)

    Jorgensen, A. M.; Lichtenberger, J.; Duffy, J.; Friedel, R. H.; Clilverd, M.; Heilig, B.; Vellante, M.; Manninen, J. K.; Raita, T.; Rodger, C. J.; Collier, A.; Reda, J.; Holzworth, R. H.; Ober, D. M.; Boudouridis, A.; Zesta, E.; Chi, P. J.

    2013-12-01

    VLF and magnetometer observations can be used to remotely sense the plasmasphere. VLF whistler waves can be used to measure the electron density and magnetic Field Line Resonance (FLR) measurements can be used to measure the mass density. In principle it is then possible to remotely map the plasmasphere with a network of ground-based stations which are also less expensive and more permanent than satellites. The PLASMON project, funded by the EU FP-7 program, is in the process of doing just this. A large number of ground-based observations will be input into a data assimilative framework which models the plasmasphere structure and dynamics. The data assimilation framework combines the Ensemble Kalman Filter with the Dynamic Global Core Plasma Model. In this presentation we will describe the plasmasphere model, the data assimilation approach that we have taken, PLASMON data and data assimilation results for specific events.

  10. GRAVITY acquisition camera: characterization results

    NASA Astrophysics Data System (ADS)

    Anugu, Narsireddy; Garcia, Paulo; Amorim, Antonio; Wiezorrek, Erich; Wieprecht, Ekkehard; Eisenhauer, Frank; Ott, Thomas; Pfuhl, Oliver; Gordo, Paulo; Perrin, Guy; Brandner, Wolfgang; Straubmeier, Christian; Perraut, Karine

    2016-08-01

    GRAVITY acquisition camera implements four optical functions to track multiple beams of Very Large Telescope Interferometer (VLTI): a) pupil tracker: a 2×2 lenslet images four pupil reference lasers mounted on the spiders of telescope secondary mirror; b) field tracker: images science object; c) pupil imager: reimages telescope pupil; d) aberration tracker: images a Shack-Hartmann. The estimation of beam stabilization parameters from the acquisition camera detector image is carried out, for every 0.7 s, with a dedicated data reduction software. The measured parameters are used in: a) alignment of GRAVITY with the VLTI; b) active pupil and field stabilization; c) defocus correction and engineering purposes. The instrument is now successfully operational on-sky in closed loop. The relevant data reduction and on-sky characterization results are reported.

  11. Preliminary results of UCN τ

    NASA Astrophysics Data System (ADS)

    Pattie, Robert; UCNtau Collaboration

    2017-01-01

    There is currently a 4 σ discrepancy between measurements of the neutron lifetime performed using cold neutron beams and those performed with ultracold neutron (UCN) storage vessels. The UCN τ experiment uses an asymmetric magneto-gravitational UCN trap with in situ counting of surviving neutrons to measure the neutron lifetime. This design eliminates a major systematic of previous bottle experiments related to the loss of UCN on material trap walls and with unloading neutrons from the storage vessel. A new in situ detection system was used in the 2015-2016 run that was able to measure the population of surviving UCN at different heights in the trap, providing important information on spectral evolution. Understanding the behavior of quasi-bound UCN in a bottle experiment is essential to achieving a subsecond precision measurement of τn. We will present the preliminary results from the 2015-2016 data set and an update on the UCN τ experiment.

  12. Results from the Magsat mission

    NASA Technical Reports Server (NTRS)

    Langel, R. A.

    1982-01-01

    The results of analyses of the data gathered by Magsat on the geomagnetic field, crustal magnetic anomalies, fields arising from external current systems, and in investigations of the earth's core, mantle, and core-mantle boundary are presented. A least squares potential function showed that the geomagnetic field was 30,000-50,000 nanoteslas at the Magsat altitude, while fields from external sources were 0-1000 nanoteslas and those from crustal sources 0-50 nanoteslas. Long-wavelength magnetic anomalies were correlated with tectonic features, sometimes reflecting undulations in the Curie isotherm at other times changes in the structure of the lower crust. Detailed anomaly maps from regional data analyses are provided, and possible future spacecraft missions for improving the resolution of contours and strengths of the anomalies are described.

  13. Wake Vortex Algorithm Scoring Results

    NASA Technical Reports Server (NTRS)

    Robins, R. E.; Delisi, D. P.; Hinton, David (Technical Monitor)

    2002-01-01

    This report compares the performance of two models of trailing vortex evolution for which interaction with the ground is not a significant factor. One model uses eddy dissipation rate (EDR) and the other uses the kinetic energy of turbulence fluctuations (TKE) to represent the effect of turbulence. In other respects, the models are nearly identical. The models are evaluated by comparing their predictions of circulation decay, vertical descent, and lateral transport to observations for over four hundred cases from Memphis and Dallas/Fort Worth International Airports. These observations were obtained during deployments in support of NASA's Aircraft Vortex Spacing System (AVOSS). The results of the comparisons show that the EDR model usually performs slightly better than the TKE model.

  14. The Recent Results from CMS

    NASA Astrophysics Data System (ADS)

    Kim, Tae Jeong

    The Large Hadron Collider (LHC) at CERN sitting astride the Franco-Swiss border near Geneva has accumulated the proton and proton collision data corresponding to an integrated luminosity of around 5 fb-1 at the center of mass energy 7 TeV in 2011 and around 20 fb-1 at 8 TeV in 2012 with the Compact Muon Solenoid (CMS) detector. The CMS detector is designed to investigate the wide range of particle physics including testing perturbative QCD and searching for Brout-Englert-Higgs (BEH) boson as well as new physics phenomena beyond the Standard Model. Observation of a new boson has moved the phase from hunting for the SM BEH boson to evaluating the consistency of this new particle with the SM expectation. The latest results from the CMS collaboration will be presented.

  15. [The Subretinal Implant - Clinical Results].

    PubMed

    Sachs, H G

    2016-11-01

    Since the end of the last century, subretinal electronic chips have been used to restore vision in patients blinded by degenerative retinal diseases such as retinitis pigmentosa. Various procedures have been suggested by different international scientific groups. The promising were the retinal-based concepts, for which there are now human data. The two distinct retina-based concepts not only differ in the site of stimulation (epi- or subretinal), but in their physiological concept. Whereas in camera-based systems (epiretinal, transchoroidal), eye movements cannot be used to detect objects, this is possible with subretinal access. It is as yet unclear as to whether this is relevant to restoring some kind of useful visual perception. This and other questions can only be answered by carefully designed human studies with sufficient patient numbers. Comparison of the visual results of the different groups is neither simple nor trivial. The implantations in each project need well trained and skilled retinal surgeons.

  16. Cryogenic Brush Seal Test Results

    NASA Technical Reports Server (NTRS)

    Proctor, Margaret P.; Walker, James F.

    1996-01-01

    Brush seals are compliant, contact seals that have long-life, low-leakage characteristics desirable for use in rocket engine turbopumps. 50.8-mm (2.0 inch) diameter brush seals with a nominal initial radial interference of 0.127-mm (0.005 inch) were tested in liquid nitrogen at shaft speeds up to 35,000 rpm and differential pressure loads up to 1.21 MPa (175 psi) per brush. The measured leakage rate of a single brush was 2-3 times less than that measured for a 12-tooth, 0.127-mm (0.005 inch) radial clearance labyrinth seal used as a baseline. Stage effects were studied and it was found that two brush seals with a large separation distance leaked less than two brushes tightly packed together. The maximum measured groove depth on the Inconel 718 rotor was 25.4 (mu)m (0.001 inch) after 4.31 hours of shaft rotation. The Haynes-25 bristles wore approximately 25.4-76.2 (mu)m (0.001-0.003 inch) under the same conditions. Three seal runner coatings, chromium carbide, Teflon impregnated chromium, and zirconium oxide, were tested in liquid hydrogen at 35,000 and 65,000 rpm with separate 50.8 mm diameter brush seals made of Haynes-25 bristles and having a nominal initial radial interference of 129 rpm. Two bare Inconel-718 rotors were also tested as a baseline. The test results revealed significant differences between the wear characteristics of the uncoated and coated seal runners. At both speeds the brush seal with the bare Inconel-718 seal runner exhibited significant bristle wear with excessive material transferring to the runner surface. In contrast, the coated seal runners inhibited the transfer and deposit of bristle material. The chromium carbide coating showed only small quantities of bristle material transferring to its surface. The Teflon impregnated chromium coating also inhibited material transfer and provided some lubrication. This coating, however, is self-sacrificing. The Teflon remained present on the low speed runner, but it was completely removed from the

  17. Monsoon '90 - Preliminary SAR results

    NASA Technical Reports Server (NTRS)

    Dubois, Pascale C.; Van Zyl, Jakob J.; Guerra, Abel G.

    1992-01-01

    Multifrequency polarimetric synthetic aperture radar (SAR) images of the Walnut Gulch watershed near Tombstone, Arizona were acquired on 28 Mar. 1990 and on 1 Aug. 1990. Trihedral corner reflectors were deployed prior to both overflights to allow calibration of the two SAR data sets. During both overflights, gravimetric soil moisture and dielectric constant measurements were made. Detailed vegetation height, density, and water content measurements were made as part of the Monsoon 1990 Experiment. Preliminary results based on analysis of the multitemporal polarimetric SAR data are presented. Only the C-band data (5.7-cm wavelength) radar images show significant difference between Mar. and Aug., with the strongest difference observed in the HV images. Based on the radar data analysis and the in situ measurements, we conclude that these differences are mainly due to changes in the vegetation and not due to the soil moisture changes.

  18. Monsoon 1990: Preliminary SAR results

    NASA Technical Reports Server (NTRS)

    Vanzyl, Jakob J.; Dubois, Pascale; Guerra, Abel

    1991-01-01

    Multifrequency polarimetric synthetic aperture radar (SAR) images of the Walnut Gulch watershed near Tombstone, Arizona were acquired on 28 Mar. 1990 and on 1 Aug. 1990. Trihedral corner reflectors were deployed prior to both overflights to allow calibration of the two SAR data sets. During both overflights, gravimetric soil moisture and dielectric constant measurements were made. Detailed vegetation height, density, and water content measurements were made as part of the Monsoon 1990 Experiment. Preliminary results based on analysis of the multitemporal polarimetric SAR data are presented. Only the C-band data (5.7-cm wavelength) radar images show significant difference between Mar. and Aug., with the strongest difference observed in the HV images. Based on the radar data analysis and the in situ measurements, we conclude that these differences are mainly due to changes in the vegetation and not due to the soil moisture changes.

  19. PLACES Aircraft Experiment Test Results

    DTIC Science & Technology

    1982-05-01

    7 7 -7 II’ DNA-TR-81-223 ~ PLACES AIRCRAFT EXPERIMENT TEST RESULTS ESL, Incorporated 495 Java Drive...Incorporated AREA , WORK UNIT NUMBERS 495 Java Drive Task S99QAXHB-00007 Sunnyvale, California 94086 II. CONTROLLING OFFICE NAME AND ADDRESS 12...a, . C . . . ’. . ’’ " ’ ’ " ’ " ." "" " " "S """" " ", " " "" :""’" " ’ ,.U I p.00 I’. (v cu C. 2Sso7 012 22S 7571 linq ~ STR IE 0i aA 0 Fiue1-16 A

  20. Gravitational microlensing searches and results

    SciTech Connect

    Alcock, C.

    1997-05-08

    Baryonic matter, in the form of Machos (MAssive Compact Halo Objects), might be a significant constituent of the dark matter that dominates the Milky Way. This article describes how surveys for Machos exploit the gravitational microlens magnification of extragalactic stars. The experimental searches for this effect monitor millions of stars, in some cases every night, looking for magnification events. The early results of these surveys indicate that Machos make up a significant fraction of the dark matter in the Milky Way, and that these objects have stellar masses. Truly substellar objects do not contribute much to the total. Additionally, the relatively high event rate towards the Galactic bulge seems to require that the bulge be elongated, and massive.

  1. Initial Blackbeard power survey results

    SciTech Connect

    Murphy, T.; Devenport, J.; Holden, D.

    1996-06-01

    The Blackbeard broadband VHF radio receiver is in low-earth orbit aboard the ALEXIS satellite. The receiver has been used to measure the transmitted power in four VHF bands (55.2-75.8, 28.0-94.8, 132.3-152.2, and 107.7-166.0 MHz) over quiet and noisy parts of the earth. The authors present the results of the survey and discuss their implications. They find that there are remote ocean areas over which the observed spectrum is largely free of man-made interference, but that the spectrum over most of the earth is dominated by broadcast VHF signals. The signal characteristics observed over a given area are quite constant when observed at different times of day and at intervals of several weeks to months. It appears that in many cases the bulk of the signal power is coming from a small number of sources.

  2. Research Results and Information Update

    NASA Astrophysics Data System (ADS)

    2011-01-01

    Research Results Monsoon behavior balanced by glaciers Research Discovers Frequent Mutations of Chromatin Significant Progress in Water Photochemistry Research Structural signature in amorphous alloy formation and plastic deformation The neural basis of Drosophila larval light/darkness preference Important roles of brain-specific carnitine palmitoyltransferase and ceramide metabolism in leptin hypothalamic control of feeding Integrin activation and internalization on soft ECM as a mechanism of induction of stem cell differentiation by ECM elasticity Determination of electron pairing symmetry of iron-based superconductor FeSe Long-Range Topological Order in Metallic Glass Information Update List of Projects Jointly Funded by NSFC and CNRS in 2011 List of Projects Jointly Funded by NSFC and ESRC in 2011 List of Projects Jointly Funded by NSFC and RS in 2011 List of Projects Jointly Funded by NSFC and RSE in 2011 Funding of Major Program Projects in 2010 Funding of Key Program Projects in 2010

  3. SOFIS FTS EM test results

    NASA Astrophysics Data System (ADS)

    Soucy, Marc-Andre A.; Levesque, Luc E.; Tanii, Jun; Kawashima, Takahiro; Nakajima, Hideaki

    2003-04-01

    The Solar Occultation FTS for Inclined-orbit Satellite (SOFIS) is a solar occultation Fourier transform spectrometer developed by the Ministry of the Environment (MOE) in Japan for the Global Change Observation Mission-A1 (GCOM-A1) satellite. GCOM-A1 will be placed in a 650 km non-sun-synchronous orbit, with an inclination angle of 69 degrees. ABB-Bomem is a sub-contractor of NTSpace (NEC-Toshiba Space) for the design and manufacturing of the FTS Engineering Model of SOFIS. SOFIS measures the vertical profile of the atmospheric constituents with 0.2 cm-1 spectral resolution for the spectral range covering 3-13 μm. The atmospheric vertical resolution of SOFIS is 1 km. The target of SOFIS measurements is a global distribution of O3, HNO3, NO2, N2O, CH4, H2O, CO2, CFC-11, CFC-12, ClONO2, aerosol extinction, atmospheric pressure and temperature. NTSpace in Japan is the prime contractor of SOFIS. The spectrometer is an adapted version of the classical Michelson interferometer using an optimized optical layout and moving retro-reflectors. A solid-state laser diode operating at 1550 nm is used as metrology source of the interferometer. Its highly folded optical design results in a high performance instrument with a compact size. SOFIS FTS implements high performance control techniques to achieve outstanding speed stability of the moving mechanism. This paper describes the test activities of the SOFIS-FTS Engineering Model (EM) and preliminary results. The performances of the FTS are presented in terms of key parameters like signal-to-noise ratio, modulation efficiency and stability. Spectra acquired are shown and test methodology and analyses are presented. Lessons learned during assembly, integration and testing are described as well as improvements planned to be implemented in the Flight Model.

  4. Huygens GCMS Results from Titan

    NASA Technical Reports Server (NTRS)

    Niemann, Hasso B.; Demick, Jaime; Kasprzak, Wayne; Atreya, Sushil; Owen, Tobias

    2007-01-01

    The Huygens Probe executed a successful entry, descent and impact on the Saturnian moon of Titan on January 14, 2005. The Gas Chromatograph Mass Spectrometer (GCMS) instrument conducted isotopic and compositional measurements throughout the two and one half hour descent from 146 km altitude, and on the surface for 69 minutes until loss of signal from the orbiting Cassini spacecraft. The GCMS incorporated a quadrupole mass filter with a secondary electron multiplier detection system. The gas sampling system provided continuous direct atmospheric composition measurements and batch sampling through three gas chromatographic (GC) columns, a chemical scrubber and a hydrocarbon enrichment cell. The GCMS gas inlet was heated to prevent condensation, and to evaporate volatiles from the surface after impact. Data products from the GCMS included altitude profiles of the major atmospheric constituents dinitrogen (N2) and methane (CH4), isotope ratios of 14N/15N, 12C/13C, and D/H, mole fractions of radiogenic argon (40Ar) and primordial argon (36Ar), and upper limits on the mole fractions of neon, krypton and xenon, which were found to be absent. Surface measurements confirmed the presence of ethane (C2H6) and cyanogen (C2N2). Later data products expanded atmospheric profiles to include the surface response of C2N2. C2H6, acetylene (C2H2), and carbon dioxide (CO2). More recent results include the profiles of benzene (C6H6) and molecular hydrogen (H2). The GCMS data are being further analyzed to obtain higher precision results and to identify other trace species ion the atmosphere and evaporating from the surface.

  5. SMART-1 Payload First Results

    NASA Astrophysics Data System (ADS)

    Foing, B. H.; SMART-1 Science Technology Working Team

    We present first results from SMART-1's science and technology payload, with a total mass of some 19 kg, featuring many innovative instruments and advanced technologies. A miniaturised high-resolution camera (AMIE) for lunar surface imaging, a near-infrared point-spectrometer (SIR) for lunar mineralogy investigation, and a very compact X-ray spectrometer (D-CIXS) with a new type of detector and micro-collimator which will provide fluorescence spectroscopy and imagery of the Moon's surface elemental composition. The payload also includes an experiment (KaTE) aimed at demonstrating deep-space telemetry and telecommand communications in the X and Ka-bands, a radio-science experiment (RSIS), a deep space optical link (Laser-Link Experiment), using the ESA Optical Ground station in Tenerife, and the validation of a system of autonomous navigation (OBAN) based on image processing. SMART-1 lunar science investigations include studies of the chemical composition of the Moon, of geophysical processes (volcanism, tectonics, cratering, erosion, deposition of ices and volatiles) for comparative planetology, and high resolution studies in preparation for future steps of lunar exploration. The mission could address several topics such as the accretional processes that led to the formation of rocky planets, and the origin and evolution of the Earth-Moon system. The SMART-1 observations will be coordinated with Japanese missions Lunar-A and SELENE, to answer open questions about comparative planetology, the origin of the Earth --Moon system, the early evolution of life, the planetary environment and the existence of in-situ resources necessary to support human presence (e.g. water, oxygen). With their science and technology results, these missions can be considered as preparatory missions for future robotic and human exploration of the solar system.

  6. Implications of Results from the Advanced Gas Reactor Fuel Development and Qualification Program on Licensing of Modular HTGRs

    SciTech Connect

    David Petti

    2001-10-01

    The high level of safety of modular high temperature gas-cooled reactor (HTGR) designs is achieved by passively maintaining core temperatures below fission product release thresholds under all envisioned accident scenarios. This level of fuel performance and fission product retention reduces the radioactive source term by many orders of magnitude relative to other reactor types but is predicated on exceptionally high coated-particle fuel fabrication quality and excellent fuel performance under normal operation and accident conditions. The Advanced Gas Reactor Fuel Development and Qualification (AGR) Program decided to qualify for uranium oxide/uranium carbide (UCO) TRISO coated-particle fuel in an operating envelope that would bound both pebble bed and prismatic modular HTGR options. By using a mixture of uranium oxide and uranium carbide, the kernel composition is engineered to minimize CO formation and fuel kernel migration, which is key to maintain to fuel integrity at the higher burnups, temperatures, and temperature gradients anticipated in prismatic HTGRs. Fuel fabrication conducted at both laboratory and engineering scale has demonstrated the ability to fabricate high quality UCO TRISO fuel with very low defects. The first irradiation (AGR 1) exposed about 300,000 TRISO fuel particles to a peak burnup of 19.6% FIMA, a peak fast-neutron fluence of about 4.3 × 1025 n/m2, and a maximum time-averaged fuel temperature of about 1,200°C without a single particle failure. The very low release of key metallic fission products (except silver) measured in post-irradiation examination (PIE) confirms the excellent performance measured under irradiation. Very low releases have been measured in accident simulation heatup testing (''safety testing'') after hundreds of hours at 1600 and 1700°C and no particle failures (no noble gas release measured) have been observed. Even after hundreds of hours at 1800°C, the releases are still very low

  7. Comparison of silver, cesium, and strontium release predictions using PARFUME with results from the AGR-1 irradiation experiment

    DOE PAGES

    Collin, Blaise P.; Petti, David A.; Demkowicz, Paul A.; ...

    2015-08-22

    The PARFUME (PARticle FUel ModEl) code was used to predict the release of fission products silver, cesium, and strontium from tristructural isotropic coated fuel particles and compacts during the first irradiation experiment (AGR-1) of the Advanced Gas Reactor Fuel Development and Qualification program. The PARFUME model for the AGR-1 experiment used the fuel compact volume average temperature for each of the 620 days of irradiation to calculate the release of silver, cesium, and strontium from a representative particle for a select number of AGR-1 compacts. Post-irradiation examination measurements provided data on release of these fission products from fuel compacts andmore » fuel particles, and retention of silver in the compacts outside of the silicon carbide (SiC) layer. PARFUME-predicted fractional release of silver, cesium, and strontium was determined and compared to the PIE measurements. For silver, comparisons show a trend of over-prediction at low burnup and under-prediction at high burnup. PARFUME has limitations in the modeling of the temporal and spatial distributions of the temperature and burnup across the compacts, which affects the accuracy of its predictions. Nevertheless, the comparisons on silver release lie in the same order of magnitude. Results show an overall over-prediction of the fractional release of cesium by PARFUME. For particles with failed SiC layers, the over-prediction is by a factor of up to 3, corresponding to a potential over-estimation of the diffusivity in uranium oxycarbide (UCO) by a factor of up to 250. For intact particles, whose release is much lower, the over-prediction is by a factor of up to 100, which could be attributed to an over-estimated diffusivity in SiC by about 40% on average. The release of strontium from intact particles is also over-predicted by PARFUME, which also points towards an over-estimated diffusivity of strontium in either SiC or UCO, or possibly both. The measured strontium fractional release

  8. Comparison of silver, cesium, and strontium release predictions using PARFUME with results from the AGR-1 irradiation experiment

    SciTech Connect

    Collin, Blaise P.; Petti, David A.; Demkowicz, Paul A.; Maki, John T.

    2015-08-22

    The PARFUME (PARticle FUel ModEl) code was used to predict the release of fission products silver, cesium, and strontium from tristructural isotropic coated fuel particles and compacts during the first irradiation experiment (AGR-1) of the Advanced Gas Reactor Fuel Development and Qualification program. The PARFUME model for the AGR-1 experiment used the fuel compact volume average temperature for each of the 620 days of irradiation to calculate the release of silver, cesium, and strontium from a representative particle for a select number of AGR-1 compacts. Post-irradiation examination measurements provided data on release of these fission products from fuel compacts and fuel particles, and retention of silver in the compacts outside of the silicon carbide (SiC) layer. PARFUME-predicted fractional release of silver, cesium, and strontium was determined and compared to the PIE measurements. For silver, comparisons show a trend of over-prediction at low burnup and under-prediction at high burnup. PARFUME has limitations in the modeling of the temporal and spatial distributions of the temperature and burnup across the compacts, which affects the accuracy of its predictions. Nevertheless, the comparisons on silver release lie in the same order of magnitude. Results show an overall over-prediction of the fractional release of cesium by PARFUME. For particles with failed SiC layers, the over-prediction is by a factor of up to 3, corresponding to a potential over-estimation of the diffusivity in uranium oxycarbide (UCO) by a factor of up to 250. For intact particles, whose release is much lower, the over-prediction is by a factor of up to 100, which could be attributed to an over-estimated diffusivity in SiC by about 40% on average. The release of strontium from intact particles is also over-predicted by PARFUME, which also points towards an over-estimated diffusivity of strontium in either SiC or UCO, or possibly both. The measured strontium fractional release from

  9. Results of arthroscopic meniscal repair

    PubMed Central

    Orlowski, María Belén; Arroquy, Damián; Chahla, Jorge; Guiñazú, Jorge; Bisso, Martín Carboni; Vilaseca, Tomás

    2017-01-01

    Objectives: Currently the arthroscopic treatment of meniscal pathology has become one of the most common procedures in orthopedic practice and although in most cases meniscectomy is done, meniscal sutures are the treatment of choice when a reparable lesion is diagnosed, especially in young patients. It has been reported that the meniscal repair leads to a lower incidence of developing degenerative changes in the long-term when compared with meniscectomy and nonsurgical treatment of meniscal injuries. The aim of this study was to determine the success rate of meniscal repair achieved in our sports medicine practice. Methods: Between 2006 and 2015, 62 meniscal tears in 58 patients with a mean age of 31 years (range 15-58) were repaired. Mean follow-up was 52 months (range 6-120 months). In 16 patients (28%) was associated with arthroscopic ACL reconstruction. The repair techniques used included outside-in sutures, inside-out sutures, all-inside sutures and a combination of techniques. Failure of the repair was defined by the requirement for repeat knee arthroscopy and partial or subtotal meniscectomy. The indication of arthroscopic revision was based on the presence of mechanical symptoms, after the suture. Results: Failure of meniscus repair occurred in four patients (failure rate: 6.45%), one case was associated with ACL reconstruction (failure rate: 6.25%) and 3 had undergone isolated meniscal suture (failure rate: 8%). The average time for the reoperation was 15 months (4-24). We had no intraoperative complications. Conclusion: The reported failure rate of meniscal repair in stable knees varies between 12% and 43%, with reports that demonstrate a clinical success rate of 100%. In this study, we obtained a success rate of 93.5%. These results are slightly higher than those in the literature, which can be attributed to careful selection of patients and the fact that clinical success tends to be better than the assessed arthroscopically. In summary, we consider the

  10. Geophysical Model Research and Results

    SciTech Connect

    Pasyanos, M; Walter, W; Tkalcic, H; Franz, G; Flanagan, M

    2004-07-07

    Geophysical models constitute an important component of calibration for nuclear explosion monitoring. We will focus on four major topics: (1) a priori geophysical models, (2) surface wave models, (3) receiver function derived profiles, and (4) stochastic geophysical models. The first, a priori models, can be used to predict a host of geophysical measurements, such as body wave travel times, and can be derived from direct regional studies or even by geophysical analogy. Use of these models is particularly important in aseismic regions or regions without seismic stations, where data of direct measurements might not exist. Lawrence Livermore National Laboratory (LLNL) has developed the Western Eurasia and North Africa (WENA) model which has been evaluated using a number of data sets, including travel times, surface waves, receiver functions, and waveform analysis (Pasyanos et al., 2004). We have joined this model with our Yellow Sea - Korean Peninsula (YSKP) model and the Los Alamos National Laboratory (LANL) East Asia model to construct a model for all of Eurasia and North Africa. Secondly, we continue to improve upon our surface wave model by adding more paths. This has allowed us to expand the region to all of Eurasia and into Africa, increase the resolution of our model, and extend results to even shorter periods (7 sec). High-resolution models exist for the Middle East and the YSKP region. The surface wave results can be inverted either alone, or in conjunction with other data, to derive models of the crust and upper mantle structure. We are also using receiver functions, in joint inversions with the surface waves, to produce profiles directly under seismic stations throughout the region. In a collaborative project with Ammon, et al., they have been focusing on stations throughout western Eurasia and North Africa, while we have been focusing on LLNL deployments in the Middle East, including Kuwait, Jordan, and the United Arab Emirates. Finally, we have been

  11. Cassini ISS Satellite Orbit Results

    NASA Astrophysics Data System (ADS)

    Spitale, J. N.; Jacobson, R. A.; Porco, C. C.; Owen, W. M.; Charnoz, S.; Murray, C. D.; Brahic, A.; Evans, M. W.; Beurle, K.; Cooper, N.; Cassini Imaging

    2004-11-01

    We report on the orbits of several small Saturnian satellites, either recovered or newly-discovered in recent Cassini imaging observations. The mean motions of Pan and Atlas have been corrected based on recent Cassini imaging combined with Voyager observations. Two small satellites, S/2004 S 1 and S/2004 S 2, have been discovered between the orbits of Mimas and Enceladus on orbits that are nearly circular and uninclined. Both bodies were observed for a fraction of one orbit on June 1, 2004 and S/2004 S 1 was subsequently detected in images shuttered three weeks earlier. Those bodies may be recovered in late October in imaging sequences designed for that purpose. A third new object was detected in images from June 21, 2004, orbiting just outside the F ring. However, a search for additional detections revealed something orbiting interior to the F ring near the longitude at which the new object would be expected 5 hours later. A low-residual orbit that crosses the F ring has been found to explain all of the observations, but it is not yet clear whether the two sequences imaged the same object or two different objects that coincidentally were found orbiting at the same longitude but at different orbital semimajor axes. These issues make its nature -- solid satellite or F ring clump -- unclear. The data, fitting procedures, and results will be discussed.

  12. Results from the NEXT Protogypes

    SciTech Connect

    Oliveira, C A.B.

    2013-10-04

    NEXT-100 is an electroluminescent high pressure Time Projection Chamber currently under construction. It will search for the neutrino-less double beta decay in 136Xe at the Canfranc Underground Laboratory. NEXT-100 aims to achieve nearly intrinsic energy resolution and to highly suppress background events by taking advantage of the unique properties of xenon in the gaseous phase as the detection medium. In order to prove the principle of operation and to study which are the best operational conditions, two prototypes were constructed: NEXT-DEMO and NEXT-DBDM. In this study we present the latest results from both prototypes. We report the improvement in terms of light collection (~ 3x) achieved by coating the walls of NEXT-DEMO with tetraphenyl butadiene (TPB), the outstanding energy resolution of 1% (Full Width Half Maximum) from NEXT-DBDM as well as the tracking capabilities of this prototype (2.1 mm RMS error for point-like depositions) achieved by using a square array of 8 x 8 SiPMs.

  13. Cosmic radioactivity and INTEGRAL results

    SciTech Connect

    Diehl, Roland

    2014-05-02

    Gamma-ray lines from radioactive decay of unstable isotopes co-produced by nucleosynthesis in massive stars and supernova have been measured since more than thirty years. Over the past ten years, INTEGRAL complemented the first sky survey made by COMPTEL. The {sup 26}A1 isotope with 1 My decay time had been first direct proof of currently-ongoing nucleosynthesis in our Galaxy. This has now become a tool to study the ∼My history of specific source regions, such as massive-star groups and associations in nearby regions which can be discriminated from the galactic-plane background, and the inner Galaxy, where Doppler shifted lines add to the astronomical information about bar and spiral structure. Recent findings suggest that superbubbles show a remarkable asymmetry, on average, in the spiral arms of our galaxy. {sup 60}Fe is co-produced by the sources of {sup 26}A1, and the isotopic ratio from their nucleosynthesis encodes stellar-structure information. Annihilation gamma-rays from positrons in interstellar space show a puzzling bright and extended source region central to our Galaxy, but also may be partly related to nucleosynthesis. {sup 56}Ni and {sup 44}Ti isotope gamma-rays have been used to constrain supernova explosion mechanisms. Here we report latest results using the accumulated multi-year database of INTEGRAL observations, and discuss their astrophysical interpretations, connecting to other traces of cosmic radioactivity and to other cosmic messengers.

  14. Experimental results on evaporation waves

    NASA Astrophysics Data System (ADS)

    Grana Otero, Jose; Parra Fabian, Ignacio

    2010-11-01

    A liquid contained in a vertical glass tube is suddenly depressurized from a high initial pressure down to one for which the stable state is vapour, so vaporization sets off at the free surface. For large enough evaporation rates, the planar vapour-liquid interface is Darrieus-Landau unstable [1], leading to the interface surface rippling close to the instability threshold. Further increasing the initial to final pressure ratio brings about evaporation waves [2,3], in which a highly corrugated front propagates downwards into the liquid. A new experimental method is presented as well as some experimental results obtained by tracking the evolution of the front with a high speed camera. In addition, a number of new phenomena related to the dynamics of bubbles growth at the walls has been uncovered. In particular, a new mode of propagation of the evaporation front is found. In this mode the front originates from below the interface, so the propagation is upwards against gravity with a curved but smooth front.[4pt] [1] F. J. Higuera, Phys. Fluids, V. 30, 679 (1987).[0pt] [2] J.E.Shepherd and B.Sturtevant, J.Fluid Mech., V.121,379 (1982).[0pt] [3] P.Reinke and G.Yadigaroglu, Int.J.Multiph. Flow, V.27,1487 (2001).

  15. Results of the PALADIN experiment

    NASA Astrophysics Data System (ADS)

    Weir, J. T.; Orzechowski, T. J.; Miller, J. L.; Chong, Y. P.; Chambers, F.; Deis, G. A.; Paul, C.; Prosnitz, D.; Scharlemann, E. T.; Halbach, K.

    1989-03-01

    PALADIN is a single pass, free laser amplifier located at the Lawrence Livermore National Laboratory. This free electron laser (FEL) is designed to run at 10.6 micrometers. The 1-kA, 45-MeV electron beam is provided by the Advanced Test Accelerator. The wiggler is 25 m long with an 8 cm period. The input optical signal to the amplifier is provided by a conventional CO2 laser, which can produce a peak input power of either 18 kW or 3.6 MW. We have demonstrated 31 dB of gain with the 18-kW input and 12.9 dB of gain for the 3.6-MW input, producing over 70 MW of optical power. Using the 18-kW input, the gain saturated at about 12 m into the wiggler; with the 3.6-MW input, the gain saturated at about 8 m. Modeling results are shown.

  16. Latest results from jet measurements

    NASA Astrophysics Data System (ADS)

    Bruna, Elena

    2009-10-01

    A first stage in understanding the phenomenon of jet quenching in the hot and dense nuclear matter has been successfully reached at RHIC through measurements of inclusive hadron suppression and di-hadron azimuthal correlations. A significant step forward in this field is being obtained by full jet reconstruction in heavy-ion collisions, that in principle should give access to the energy of the hard scattering independent of the presence of the medium and should enable the study of jet quenching at the partonic level. Due to the intrinsic difficulties of such a measurement in the high multiplicity environment, this is an innovative analysis and the first results of full jet reconstruction were obtained only over the last year thanks to the recently developed jet-finding techniques. We discuss the current methods to treat the large background, which is the main critical aspect that makes full jet reconstruction a challenge at RHIC. New measurements directed to address the mechanisms of partonic energy loss in hot QCD matter are presented. These measurements include the ratio of inclusive jet cross sections in Au+Au and p+p and the comparison of jet fragmentation functions in Au+Au and p+p.

  17. Visible Nulling Coronagraph Testbed Results

    NASA Technical Reports Server (NTRS)

    Lyon, Richard G.; Clampin, Mark; Melnick, Gary; Tolls, Volker; Woodruff, Robert; Vasudevan, Gopal; Rizzo, Maxime; Thompson, Patrick

    2009-01-01

    The Extrasolar Planetary Imaging Coronagraph (EPIC) is a NASA Astrophysics Strategic Mission Concept study and a proposed NASA Discovery mission to image and characterize extrasolar giant planets in orbits with semi-major axes between 2 and 10 AU. EPIC would provide insights into the physical nature of a variety of planets in other solar systems complimenting radial velocity (RV) and astrometric planet searches. It will detect and characterize the atmospheres of planets identified by radial velocity surveys, determine orbital inclinations and masses, characterize the atmospheres around A and F stars, observed the inner spatial structure and colors of inner Spitzer selected debris disks. EPIC would be launched to heliocentric Earth trailing drift-away orbit, with a 5-year mission lifetime. The starlight suppression approach consists of a visible nulling coronagraph (VNC) that enables starlight suppression in broadband light from 480-960 nm. To demonstrate the VNC approach and advance it's technology readiness we have developed a laboratory VNC and have demonstrated white light nulling. We will discuss our ongoing VNC work and show the latest results from the VNC testbed.

  18. Solar neutrinos: Interpretation of results

    NASA Astrophysics Data System (ADS)

    Smirnov, A. Yu.

    2003-04-01

    Recent SNO results give strong evidence that the solar neutrinos undergo flavor conversion. The main issue now is the identification of the mechanism of conversion. The LMA MSW solution with Δm2 = (5-7)·10 -5 eV 2, tan 2≡ = 0.35-0.45 looks rather plausible: it fits well the experimental data and our new theoretical prejudices. In the LMA case, KamLAND should see (0.5 - 0.7) reduced signal. VAC-QVO and LOW are accepted at about 3δ-level. The SMA solution is practically excluded. No sub-leading effects produced by Ue3 and admixture of sterile neutrino have been found. The fit becomes worse with an increase of Ue3 (for LMA) and a νs admixture. Still a (30 - 50)% presence of the sterile neutrino is allowed. Solutions based on the neutrino spin-flip in the magnetic fields of the Sun as well as on non-standard neutrino interactions give a good fit of the data. If KamLAND confirms LMA MSW, the spin-flip and non-standard interactions can be considered (and will be searched for) as sub-leading effects.

  19. Results from the PAMELA experiment.

    NASA Astrophysics Data System (ADS)

    Mori, Nicola

    2014-08-01

    PAMELA is a satellite-borne experiment, aimed at precision measurements of the charged, light component of the cosmic-ray spectrum. It consists of a magnetic spectrometer, a time-of-flight system, an electromagnetic calorimeter, an anticoincidence system and a neutron detector. The main focus of the experiment is on antimatter; other components of the spectrum that can be investigated include electrons and light nuclei up to oxygen. Thanks to its placement out of the terrestrial atmosphere and the long exposure time, PAMELA is able to provide data with low systematic effects and high statistical significance. Its semi-polar orbit allows to detect particles of solar origin and to investigate the effects of the solar activity on the low-energy part of the galactic component of the spectrum (solar modulation). The redundancy of its detectors allows to monitor the detector performance and to measure the data selection efficiency directly from flight data. The instrument has been launched in 2006 and it is continuously taking data since then. The most important and recent results from the experiment will be presented.

  20. Mark III results from SPEAR

    SciTech Connect

    Toki, W.

    1983-11-01

    First results from the MARK III detector at SPEAR are presented based on 2.7 million J/psi decays. The eta/sub c/ is observed in three modes, J/psi ..-->.. ..gamma..eta/sub c/, (eta/sub c/ ..-->.. rho anti rho, eta..pi../sup +/..pi../sup -/, and phi phi). Using the phi phi mode, the eta/sub c/ spin-parity is determined to be 0/sup -/. The known radiative J/psi decays J/psi ..-->.. ..gamma..f(f ..-->.. ..pi../sup +/..pi../sup -/), ..gamma..eta'(eta' ..-->.. ..gamma..rho/sup 0/, eta..pi../sup +/..pi../sup -/), ..gamma..f'(f' ..-->.. kappa/sup +/kappa/sup -/), ..gamma..theta(theta ..-->.. kappa anti kappa), and ..gamma..iota(iota ..-->.. ..pi..kappa anti kappa) are observed and their branching ratios found to be in agreement with previous measurements. In the J/psi ..-->.. ..gamma..kappa/sup +/kappa/sup -/ mode a new state is observed at 2.22 GeV and in the J/psi ..-->.. ..gamma gamma..rho/sup 0/ and ..gamma..eta..pi../sup +/..pi../sup -/ modes evidence for new structures near 1.4 GeV is presented. 29 references.

  1. EUPORIAS: plans and preliminary results

    NASA Astrophysics Data System (ADS)

    Buontempo, C.

    2013-12-01

    Recent advances in our understanding and ability to forecast climate variability have meant that skilful predictions are beginning to be routinely made on seasonal to decadal (s2d) timescales. Such forecasts have the potential to be of great value to a wide range of decision-making, where outcomes are strongly influenced by variations in the climate. In 2012 the European Commission funded EUPORIAS, a four year long project to develop prototype end-to-end climate impact prediction services operating on a seasonal to decadal timescale, and assess their value in informing decision-making. EUPORIAS commenced on 1 November 2012, coordinated by the UK Met Office leading a consortium of 24 organisations representing world-class European climate research and climate service centres, expertise in impacts assessments and seasonal predictions, two United Nations agencies, specialists in new media, and commercial companies in climate-vulnerable sectors such as energy, water and tourism. The poster describes the setup of the project, its main outcome and some of the very preliminary results.

  2. First photometry results from Gaia

    NASA Astrophysics Data System (ADS)

    Brown, Anthony

    2015-08-01

    An overview of the Gaia Photometric Processing is presented. The Gaia photometry consists of the white light (330-1050 nm) G-band, and low resolution spectrophotometry realized by two prisms dispersing all the light entering the field of view. One disperser - called BP for Blue Photometer- operates in the wavelength range 330-680 nm; the other - called RP for Red Photometer - covers the wavelength range 640-1050 nm. The light collected by BP and RP can also be integrated into two broad bands, G_BP and G_RP.This photometric data reduction is based on the overall principle of a self-calibrating system improved by iteration. The input data includes flux (G, G_BP, G_RP) and the low-resolution spectral data. The calibration models and algorithms used are described. Initial validation results are shown which indicate the photometric quality of the preliminary calibrated data. Expectations for the quality of the photometric data to be included in the first public data release (mid-2016) are discussed.

  3. Results from the NEXT Protogypes

    DOE PAGES

    Oliveira, C A.B.

    2013-10-04

    NEXT-100 is an electroluminescent high pressure Time Projection Chamber currently under construction. It will search for the neutrino-less double beta decay in 136Xe at the Canfranc Underground Laboratory. NEXT-100 aims to achieve nearly intrinsic energy resolution and to highly suppress background events by taking advantage of the unique properties of xenon in the gaseous phase as the detection medium. In order to prove the principle of operation and to study which are the best operational conditions, two prototypes were constructed: NEXT-DEMO and NEXT-DBDM. In this study we present the latest results from both prototypes. We report the improvement in termsmore » of light collection (~ 3x) achieved by coating the walls of NEXT-DEMO with tetraphenyl butadiene (TPB), the outstanding energy resolution of 1% (Full Width Half Maximum) from NEXT-DBDM as well as the tracking capabilities of this prototype (2.1 mm RMS error for point-like depositions) achieved by using a square array of 8 x 8 SiPMs.« less

  4. Results from p p colliders

    SciTech Connect

    Huth, J.

    1991-08-01

    Recent results {bar p}p colliders are presented. From elastic scattering experiments at the Tevatron, an average value of {sigma}{sub tot} = 72.1{plus minus}2 mb is reported, along with a new measurement of {rho} = 0.13 {plus minus} 0.7. New measurements of jet direct photon and high p{sub t} W and Z production are compared to more precise, higher order predictions from perturbative QCD. Recently available data on the W mass and width give combined values for M{sub W} = 80.14{plus minus}0.27 GeV/c{sup 2}, and {Gamma}(W) =2. 14 {plus minus} 0.08 GeV. From electroweak radiative corrections and M{sub W}, one finds M{sub top} = 130{plus minus}40 GeV/c{sup 2}, with a 95% C.L. upper limit at 210 GeV/c{sup 2}. Current limits on M{sub top} are presented, along with a review of the prospects for top discovery. From jet data there is no evidence of quark substructure down to the distance scale of 1.4 {times} 10{sup {minus}17} cm, nor is there evidence for supersymmetry or heavy gauge bosons at {bar p}p colliders, allowing lower limits on M{sub W}, > 520 GeV/c{sup 2} and M{sub Z} 412 GeV/c{sup 2}. 66 refs., 26 figs.

  5. SAA drift:experimental results

    NASA Astrophysics Data System (ADS)

    Grigoryan, O. R.; Kudela, K.; Romashova, V. V.; Drozdov, A. Yu.

    According to the paleomagnetic analysis there are variations of Earth's magnetic field connected with magnetic momentum changing. Besides these variations affects on the trapped belt South Atlantic Anomaly (SAA) location. Indeed different observations including Space Shuttle short-time flights approved the existence SAA westward drift with speed 0.1-1.0 (deg/year) and northward drift with speed approximately 0.1 (deg/year). In this work we present the analysis of experimental results obtained in SINP MSU in 1972-2003 from different satellites. There were analyzed the fluxes of protons with energy > 50 MeV, gamma quanta with energy > 500 keV and neutrons with energy 0.1-1.0 MeV in SAA area and their maxima location. The data about fluxes were obtained onboard the orbital stations ``Salut-6'' (1979), MIR (1991, 1998) and ISS (2003) by the identical experimental equipment. The comparison of the data obtained during these two decades of investigations confirms the fact of the SAA westward drift. Moreover the same analysis of maximum flux location of electrons with hundreds keV energy (satellites ``Kosmos-484'' (1972), ``Interkosmos-17'' (1977) and ``Activny'' (``Interkosmos-24'', 1991)) confirmed not only the SAA westward drift but northward drift also.

  6. Preliminary results of ANAIS-25

    NASA Astrophysics Data System (ADS)

    Amaré, J.; Cebrián, S.; Cuesta, C.; García, E.; Ginestra, C.; Martínez, M.; Oliván, M. A.; Ortigoza, Y.; Ortiz de Solórzano, A.; Pobes, C.; Puimedón, J.; Sarsa, M. L.; Villar, J. A.; Villar, P.

    2014-04-01

    The ANAIS (Annual Modulation with NaI(Tl) Scintillators) experiment aims at the confirmation of the DAMA/LIBRA signal using the same target and technique at the Canfranc Underground Laboratory. 250 kg of ultrapure NaI(Tl) crystals will be used as a target, divided into 20 modules, each coupled to two photomultipliers. Two NaI(Tl) crystals of 12.5 kg each, grown by Alpha Spectra from a powder having a potassium level under the limit of our analytical techniques, form the ANAIS-25 set-up. The background contributions are being carefully studied and preliminary results are presented: their natural potassium content in the bulk has been quantified, as well as the uranium and thorium radioactive chains presence in the bulk through the discrimination of the corresponding alpha events by PSA, and due to the fast commissioning, the contribution from cosmogenic activated isotopes is clearly identified and their decay observed along the first months of data taking. Following the procedures established with ANAIS-0 and previous prototypes, bulk NaI(Tl) scintillation events selection and light collection efficiency have been also studied in ANAIS-25.

  7. Mobile evaporator corrosion test results

    SciTech Connect

    Rozeveld, A.; Chamberlain, D.B.

    1997-05-01

    Laboratory corrosion tests were conducted on eight candidates to select a durable and cost-effective alloy for use in mobile evaporators to process radioactive waste solutions. Based on an extensive literature survey of corrosion data, three stainless steel alloys (304L, 316L, AL-6XN), four nickel-based alloys (825, 625, 690, G-30), and titanium were selected for testing. The corrosion tests included vapor phase, liquid junction (interface), liquid immersion, and crevice corrosion tests on plain and welded samples of candidate materials. Tests were conducted at 80{degrees}C for 45 days in two different test solutions: a nitric acid solution. to simulate evaporator conditions during the processing of the cesium ion-exchange eluant and a highly alkaline sodium hydroxide solution to simulate the composition of Tank 241-AW-101 during evaporation. All of the alloys exhibited excellent corrosion resistance in the alkaline test solution. Corrosion rates were very low and localized corrosion was not observed. Results from the nitric acid tests showed that only 316L stainless steel did not meet our performance criteria. The 316L welded interface and crevice specimens had rates of 22.2 mpy and 21.8 mpy, respectively, which exceeds the maximum corrosion rate of 20 mpy. The other welded samples had about the same corrosion resistance as the plain samples. None of the welded samples showed preferential weld or heat-affected zone (HAZ) attack. Vapor corrosion was negligible for all alloys. All of the alloys except 316L exhibited either {open_quotes}satisfactory{close_quotes} (2-20 mpy) or {open_quotes}excellent{close_quotes} (<2 mpy) corrosion resistance as defined by National Association of Corrosion Engineers. However, many of the alloys experienced intergranular corrosion in the nitric acid test solution, which could indicate a susceptibility to stress corrosion cracking (SCC) in this environment.

  8. Corral Monitoring System assessment results

    SciTech Connect

    Filby, E.E.; Haskel, K.J.

    1998-03-01

    This report describes the results of a functional and operational assessment of the Corral Monitoring Systems (CMS), which was designed to detect and document accountable items entering or leaving a monitored site. Its development was motivated by the possibility that multiple sites in the nuclear weapons states of the former Soviet Union might be opened to such monitoring under the provisions of the Strategic Arms Reduction Treaty. The assessment was performed at three levels. One level evaluated how well the planned approach addressed the target application, and which involved tracking sensitive items moving into and around a site being monitored as part of an international treaty or other agreement. The second level examined the overall design and development approach, while the third focused on individual subsystems within the total package. Unfortunately, the system was delivered as disassembled parts and pieces, with very poor documentation. Thus, the assessment was based on fragmentary operating data coupled with an analysis of what documents were provided with the system. The system design seemed to be a reasonable match to the requirements of the target application; however, important questions about site manning and top level administrative control were left unanswered. Four weaknesses in the overall design and development approach were detected: (1) poor configuration control and management, (2) inadequate adherence to a well defined architectural standard, (3) no apparent provision for improving top level error tolerance, and (4) weaknesses in the object oriented programming approach. The individual subsystems were found to offer few features or capabilities that were new or unique, even at the conceptual level. The CMS might possibly have offered a unique combination of features, but this level of integration was never realized, and it had no unique capabilities that could be readily extracted for use in another system.

  9. An overview of FTU results

    NASA Astrophysics Data System (ADS)

    Buratti, P.; Alessi, E.; Amicucci, L.; Angelini, B.; Apicella, M. L.; Apruzzese, G.; Artaserse, G.; Barbato, E.; Belli, F.; Bertocchi, A.; Bin, W.; Boncagni, L.; Botrugno, A.; Briguglio, S.; Bruschi, A.; Calabrò, G.; Cardinali, A.; Castaldo, C.; Ceccuzzi, S.; Centioli, C.; Cesario, R.; Cianfarani, C.; Cirant, S.; Crisanti, F.; D'Arcangelo, O.; De Angeli, M.; De Angelis, R.; Di Matteo, L.; Di Troia, C.; Esposito, B.; Farina, D.; Figini, L.; Fogaccia, G.; Frigione, D.; Fusco, V.; Gabellieri, L.; Galperti, C.; Garavaglia, S.; Giovannozzi, E.; Granucci, G.; Grossetti, G.; Grosso, G.; Guimarães-Filho, Z. O.; Iannone, F.; Krivska, A.; Kroegler, H.; Lazzaro, E.; Lontano, M.; Maddaluno, G.; Marchetto, C.; Marinucci, M.; Marocco, D.; Mazzitelli, G.; Mazzotta, C.; Milovanov, A.; Minelli, D.; Mirizzi, F. C.; Moro, G. A.; Napoli, F.; Nowak, S.; Orsitto, F. P.; Pacella, D.; Panaccione, L.; Panella, M.; Pericoli-Ridolfini, V.; Podda, S.; Pizzuto, A.; Pucella, G.; Ramogida, G.; Ravera, G.; Romano, A.; Sozzi, C.; Tuccillo, A. A.; Tudisco, O.; Viola, B.; Vitale, V.; Vlad, G.; Zanza, V.; Zerbini, M.; Zonca, F.; Aquilini, M.; Cefali, P.; Di Ferdinando, E.; Di Giovenale, S.; Giacomi, G.; Gravanti, F.; Grosso, A.; Mellera, V.; Mezzacappa, M.; Pensa, A.; Petrolini, P.; Piergotti, V.; Raspante, B.; Rocchi, G.; Sibio, A.; Tilia, B.; Torelli, C.; Tulli, R.; Vellucci, M.; Zannetti, D.

    2013-10-01

    Since the 2010 IAEA-FEC Conference, FTU has exploited improvements in cleaning procedures and in the density control system to complete a systematic exploration of access to high-density conditions in a wide range of plasma currents and magnetic fields. The line-averaged densities at the disruptive limit increased more than linearly with the toroidal field, while no dependence on plasma current was found; in fact, the maximum density of 4.3 × 1020 m-3 was reached at B = 8 T even at the minimum current of 0.5 MA, corresponding to twice the Greenwald limit. The lack of plasma current dependence was due to the increase in density peaking with the safety factor. Experiments with the 140 GHz electron cyclotron resonance heating (ECRH) system were focused on the sawtooth (ST) period control and on the commissioning of a new launcher with real-time steering capability that will act as the front-end actuator of a real-time system for ST period control and tearing mode stabilization. Various ECRH and electron cyclotron current-drive modulation schemes were used; with the fastest one, the ST period synchronized with an 8 ms modulation period. The observed period variations were simulated using the JETTO code with a critical shear model for the crash trigger. The new launcher was of the plug-in type, allowing quick insertion and connection to the transmission line. Both beam characteristics and steering speed were in line with design expectation. Experimental results on the connection between improved coupling of lower hybrid waves in high-density plasmas and reduced wave spectral broadening were interpreted by fully kinetic, non-linear model calculations. A dual-frequency, time-of-flight diagnostic for the measurement of density profiles was developed and successfully tested. Fishbone-like instabilities driven by energetic electrons were simulated by the hybrid MHD-gyrokinetic XHMGC code.

  10. Comparison of fission product release predictions using PARFUME with results from the AGR-1 safety tests

    SciTech Connect

    Blaise Collin

    2014-09-01

    Safety tests were conducted on fourteen fuel compacts from AGR-1, the first irradiation experiment of the Advanced Gas Reactor (AGR) Fuel Development and Qualification program, at temperatures ranging from 1600 to 1800°C to determine fission product release at temperatures that bound reactor accident conditions. The PARFUME (PARticle FUel ModEl) code was used to predict the release of fission products silver, cesium, strontium, and krypton from fuel compacts containing tristructural isotropic (TRISO) coated particles during the safety tests, and the predicted values were compared with experimental results. Preliminary comparisons between PARFUME predictions and post-irradiation examination (PIE) results of the safety tests show different trends in the prediction of the fractional release depending on the species, and it leads to different conclusions regarding the diffusivities used in the modeling of fission product transport in TRISO-coated particles: • For silver, the diffusivity in silicon carbide (SiC) might be over-estimated by a factor of at least 102 to 103 at 1600°C and 1700°C, and at least 10 to 102 at 1800°C. The diffusivity of silver in uranium oxy-carbide (UCO) might also be over-estimated, but the available data are insufficient to allow definitive conclusions to be drawn. • For cesium, the diffusivity in UCO might be over-estimated by a factor of at least 102 to 103 at 1600°C, 105 at 1700°C, and 103 at 1800°C. The diffusivity of cesium in SiC might also over-estimated, by a factor of 10 at 1600°C and 103 at 1700°C, based upon the comparisons between calculated and measured release fractions from intact particles. There is no available estimate at 1800°C since all the compacts heated up at 1800°C contain particles with failed SiC layers whose release dominates the release from intact particles. • For strontium, the diffusivity in SiC might be over-estimated by a factor of 10 to 102 at 1600 and 1700°C, and 102 to 103 at 1800°C. These

  11. Introduction and Summary of Results

    NASA Astrophysics Data System (ADS)

    Yaghjian, Arthur D.

    The primary purpose of this work is to determine an equation of motion for the classical Lorentz model of the electron that is consistent with causal solutions to the Maxwell-Lorentz equations, the relativistic generalization of Newton's second law of motion, and Einstein's mass-energy relation. (The latter two laws of physics were not discovered until after the original works of Lorentz, Abraham, and Poincaré. The hope of Lorentz and Abraham for deriving the equation of motion of an electron from the self force determined by the Maxwell-Lorentz equations alone was not fully realized.) The work begins by reviewing the contributions of Lorentz, Abraham, Poincaré, and Schott to this century-old problem of finding the equation of motion of an extended electron. Their original derivations, which were based on the Maxwell-Lorentz equations and assumed a zero bare mass, are modified and generalized to obtain a nonzero bare mass and consistent force and power equations of motion. By looking at the Lorentz model of the electron as a charged insulator, general expressions are derived for the binding forces that Poincaré postulated to hold the charge distribution together. A careful examination of the classic Lorentz-Abraham derivation reveals that the self electromagnetic force must be modified during a short time interval after the external force is first applied and after all other nonanalytic points in time of the external force. The resulting modification to the equation of motion, although slight, eliminates the noncausal pre-acceleration (and pre-deceleration) that has plagued the solution to the Lorentz-Abraham equation of motion. As part of the analysis, general momentum and energy relations are derived and interpreted physically for the solutions to the equation of motion, including “hyperbolic” and “runaway” solutions. Also, a stress-momentum-energy tensor that includes the binding, bare-mass, and electromagnetic momentum-energy densities is derived for

  12. Overview of ASDEX Upgrade results

    NASA Astrophysics Data System (ADS)

    Stroth, U.; Adamek, J.; Aho-Mantila, L.; Äkäslompolo, S.; Amdor, C.; Angioni, C.; Balden, M.; Bardin, S.; Barrera Orte, L.; Behler, K.; Belonohy, E.; Bergmann, A.; Bernert, M.; Bilato, R.; Birkenmeier, G.; Bobkov, V.; Boom, J.; Bottereau, C.; Bottino, A.; Braun, F.; Brezinsek, S.; Brochard, T.; Brüdgam, M.; Buhler, A.; Burckhart, A.; Casson, F. J.; Chankin, A.; Chapman, I.; Clairet, F.; Classen, I. G. J.; Coenen, J. W.; Conway, G. D.; Coster, D. P.; Curran, D.; da Silva, F.; de Marné, P.; D'Inca, R.; Douai, D.; Drube, R.; Dunne, M.; Dux, R.; Eich, T.; Eixenberger, H.; Endstrasser, N.; Engelhardt, K.; Esposito, B.; Fable, E.; Fischer, R.; Fünfgelder, H.; Fuchs, J. C.; Gál, K.; García Muñoz, M.; Geiger, B.; Giannone, L.; Görler, T.; da Graca, S.; Greuner, H.; Gruber, O.; Gude, A.; Guimarais, L.; Günter, S.; Haas, G.; Hakola, A. H.; Hangan, D.; Happel, T.; Härtl, T.; Hauff, T.; Heinemann, B.; Herrmann, A.; Hobirk, J.; Höhnle, H.; Hölzl, M.; Hopf, C.; Houben, A.; Igochine, V.; Ionita, C.; Janzer, A.; Jenko, F.; Kantor, M.; Käsemann, C.-P.; Kallenbach, A.; Kálvin, S.; Kantor, M.; Kappatou, A.; Kardaun, O.; Kasparek, W.; Kaufmann, M.; Kirk, A.; Klingshirn, H.-J.; Kocan, M.; Kocsis, G.; Konz, C.; Koslowski, R.; Krieger, K.; Kubic, M.; Kurki-Suonio, T.; Kurzan, B.; Lackner, K.; Lang, P. T.; Lauber, P.; Laux, M.; Lazaros, A.; Leipold, F.; Leuterer, F.; Lindig, S.; Lisgo, S.; Lohs, A.; Lunt, T.; Maier, H.; Makkonen, T.; Mank, K.; Manso, M.-E.; Maraschek, M.; Mayer, M.; McCarthy, P. J.; McDermott, R.; Mehlmann, F.; Meister, H.; Menchero, L.; Meo, F.; Merkel, P.; Merkel, R.; Mertens, V.; Merz, F.; Mlynek, A.; Monaco, F.; Müller, S.; Müller, H. W.; Münich, M.; Neu, G.; Neu, R.; Neuwirth, D.; Nocente, M.; Nold, B.; Noterdaeme, J.-M.; Pautasso, G.; Pereverzev, G.; Plöckl, B.; Podoba, Y.; Pompon, F.; Poli, E.; Polozhiy, K.; Potzel, S.; Püschel, M. J.; Pütterich, T.; Rathgeber, S. K.; Raupp, G.; Reich, M.; Reimold, F.; Ribeiro, T.; Riedl, R.; Rohde, V.; Rooij, G. v.; Roth, J.; Rott, M.; Ryter, F.; Salewski, M.; Santos, J.; Sauter, P.; Scarabosio, A.; Schall, G.; Schmid, K.; Schneider, P. A.; Schneider, W.; Schrittwieser, R.; Schubert, M.; Schweinzer, J.; Scott, B.; Sempf, M.; Sertoli, M.; Siccinio, M.; Sieglin, B.; Sigalov, A.; Silva, A.; Sommer, F.; Stäbler, A.; Stober, J.; Streibl, B.; Strumberger, E.; Sugiyama, K.; Suttrop, W.; Tala, T.; Tardini, G.; Teschke, M.; Tichmann, C.; Told, D.; Treutterer, W.; Tsalas, M.; Van Zeeland, M. A.; Varela, P.; Veres, G.; Vicente, J.; Vianello, N.; Vierle, T.; Viezzer, E.; Viola, B.; Vorpahl, C.; Wachowski, M.; Wagner, D.; Wauters, T.; Weller, A.; Wenninger, R.; Wieland, B.; Willensdorfer, M.; Wischmeier, M.; Wolfrum, E.; Würsching, E.; Yu, Q.; Zammuto, I.; Zasche, D.; Zehetbauer, T.; Zhang, Y.; Zilker, M.; Zohm, H.

    2013-10-01

    The medium size divertor tokamak ASDEX Upgrade (major and minor radii 1.65 m and 0.5 m, respectively, magnetic-field strength 2.5 T) possesses flexible shaping and versatile heating and current drive systems. Recently the technical capabilities were extended by increasing the electron cyclotron resonance heating (ECRH) power, by installing 2 × 8 internal magnetic perturbation coils, and by improving the ion cyclotron range of frequency compatibility with the tungsten wall. With the perturbation coils, reliable suppression of large type-I edge localized modes (ELMs) could be demonstrated in a wide operational window, which opens up above a critical plasma pedestal density. The pellet fuelling efficiency was observed to increase which gives access to H-mode discharges with peaked density profiles at line densities clearly exceeding the empirical Greenwald limit. Owing to the increased ECRH power of 4 MW, H-mode discharges could be studied in regimes with dominant electron heating and low plasma rotation velocities, i.e. under conditions particularly relevant for ITER. The ion-pressure gradient and the neoclassical radial electric field emerge as key parameters for the transition. Using the total simultaneously available heating power of 23 MW, high performance discharges have been carried out where feed-back controlled radiative cooling in the core and the divertor allowed the divertor peak power loads to be maintained below 5 MW m-2. Under attached divertor conditions, a multi-device scaling expression for the power-decay length was obtained which is independent of major radius and decreases with magnetic field resulting in a decay length of 1 mm for ITER. At higher densities and under partially detached conditions, however, a broadening of the decay length is observed. In discharges with density ramps up to the density limit, the divertor plasma shows a complex behaviour with a localized high-density region in the inner divertor before the outer divertor detaches

  13. Overview of ASDEX Upgrade results

    NASA Astrophysics Data System (ADS)

    Gruber, O.; Bosch, H.-S.; Günter, S.; Herrmann, A.; Kallenbach, A.; Kaufmann, M.; Krieger, K.; Lackner, K.; Mertens, V.; Neu, R.; Ryter, F.; Schweinzer, J.; Stäbler, A.; Suttrop, W.; Wolf, R.; Asmussen, K.; Bard, A.; Becker, G.; Behler, K.; Behringer, K.; Bergmann, A.; Bessenrodt-Weberpals, M.; Borrass, K.; Braams, B.; Brambilla, M.; Brandenburg, R.; Braun, F.; Brinkschulte, H.; Brückner, R.; Brüsehaber, B.; Büchl, K.; Buhler, A.; Callaghan, H. P.; Carlson, A.; Coster, D. P.; Cupido, L.; de Peña Hempel, S.; Dorn, C.; Drube, R.; Dux, R.; Egorov, S.; Engelhardt, W.; Fahrbach, H.-U.; Fantz, U.; Feist, H.-U.; Franzen, P.; Fuchs, J. C.; Fussmann, G.; Gafert, J.; Gantenbein, G.; Gehre, O.; Geier, A.; Gernhardt, J.; Gubanka, E.; Gude, A.; Haas, G.; Hallatschek, K.; Hartmann, D.; Heinemann, B.; Herppich, G.; Herrmann, W.; Hofmeister, F.; Holzhauer, E.; Jacobi, D.; Kakoulidis, M.; Karakatsanis, N.; Kardaun, O.; Khutoretski, A.; Kollotzek, H.; Kötterl, S.; Kraus, W.; Kurzan, B.; Kyriakakis, G.; Lang, P. T.; Lang, R. S.; Laux, M.; Lengyel, L. L.; Leuterer, F.; Lorenz, A.; Maier, H.; Manso, M.; Maraschek, M.; Markoulaki, M.; Mast, K.-F.; McCarthy, P. J.; Meisel, D.; Meister, H.; Merkel, R.; Meskat, J. P.; Müller, H. W.; Münich, M.; Murmann, H.; Napiontek, B.; Neu, G.; Neuhauser, J.; Niethammer, M.; Noterdaeme, J.-M.; Pautasso, G.; Peeters, A. G.; Pereverzev, G.; Pinches, S.; Raupp, G.; Reinmüller, K.; Riedl, R.; Rohde, V.; Röhr, H.; Roth, J.; Salzmann, H.; Sandmann, W.; Schilling, H.-B.; Schlögl, D.; Schmidtmann, K.; Schneider, H.; Schneider, R.; Schneider, W.; Schramm, G.; Schweizer, S.; Schwörer, R. R.; Scott, B. D.; Seidel, U.; Serra, F.; Sesnic, S.; Sihler, C.; Silva, A.; Speth, E.; Steuer, K.-H.; Stober, J.; Streibl, B.; Thoma, A.; Treutterer, W.; Troppmann, M.; Tsois, N.; Ullrich, W.; Ulrich, M.; Varela, P.; Verbeek, H.; Vollmer, O.; Wedler, H.; Weinlich, M.; Wenzel, U.; Wesner, F.; Wunderlich, R.; Xantopoulos, N.; Yu, Q.; Zasche, D.; Zehetbauer, T.; Zehrfeld, H.-P.; Zohm, H.; Zouhar, M.

    1999-09-01

    The closed ASDEX Upgrade Divertor II, `LYRA', is capable of handling heating powers of up to 20 MW or P/R of 12 MW/m, owing to a reduction of the maximum heat flux to the target plates by more than a factor of 2 compared with the open Divertor I. This reduction is caused by high radiative losses from carbon and hydrogen inside the divertor region and is in agreement with B2-EIRENE modelling predictions. At medium densities in the H mode, the type I ELM behaviour shows no dependence on the heating method (NBI, ICRH). ASDEX Upgrade-JET dimensionless identity experiments showed compatibility of the L-H transition with core physics constraints, while in the H mode confinement, inconsistencies with the invariance principle were established. At high densities close to the Greenwald density, the MHD limited edge pressures, the influence of divertor detachment on separatrix parameters and increasing edge transport lead to limited edge densities and finally to temperatures below the critical edge temperatures for H mode. This results in a drastic increase of the H mode threshold power and an upper H mode density limit with gas puff refuelling. The H mode confinement degradation approaching this density limit is caused by the ballooning mode limited edge pressures and `stiff' temperature profiles relating core and edge temperatures. Repetitive high field side pellet injection allows for H mode operation well above the Greenwald density; moreover, higher confinement than with gas fuelling is found up to the highest densities. Neoclassical tearing modes limit the achievable β depending on the collisionality at the resonant surface. In agreement with the polarization current model, the onset β is found to be proportional to the ion gyroradius in the collisionless regime, while higher collisionalities are stabilizing. The fractional energy loss connected with saturated modes at high pressures is about 25%. A reduction of neoclassical mode amplitude and an increase of β have

  14. [Results for SHEBA/FIRE

    NASA Technical Reports Server (NTRS)

    Valero, Francisco P. J.

    2003-01-01

    The Atmospheric Research Laboratory's Radiation Measurement System (RAMS) was on the NCAR C-130 aircraft in May and July 1998, collecting radiometric data on the science flights conducted in the vicinity of the Surface Heat Budget of the Arctic Ocean (SHEBA) ship. These measurements were part of the FIRE Arctic Cloud Experiment (FIRE ACE). Analysis of some of the data focused on the absorption, reflection, and transmittance of Arctic clouds, especially compared to model results. In order to assess the absorption of solar radiation by the clear and cloudy atmosphere in the Arctic the measurements from the radiometers were combined in pairs of above-cloud segments and below-cloud segments. To get these pairs, the data for all sixteen of the flights (8 in May and 8 in July) were examined for occurrences of low-altitude segments in proximity to high-altitude segments. The low-altitude data are then treated as measurements of the bottom of a layer and the high-altitude data are taken as measurements of the top of the layer. With measurements of the upwelling and downwelling irradiances above and below a layer one can determine the reflectance, transmittance, and absorptance of the layer. Attachment: Doelling, D.R., P. Minnis, D.A. Spangenberg, V. Chakrapani, A. Mahesh, S.K. Pope, and F.P.J. Valero, Cloud radiative forcing at the top of the atmosphere during FIRE ACE derived from AVHRR data, J. Geophys. Res. 106, 15,279-15,296,2001. Minnis, P., D.R. Doelling, D.A. Spangenberg, A. Mahesh, S.K. Pope, and F.P.J. Valero, AVHRR-derived cloud radiative forcing over the ARM NSA and SHEBA site during FIRE ACE, abstract submitted to the ARM Science Team Meeting, San Antonio, TX, M a . 13-17,2000. Pope, S.K., and F.P.J. Valero, Measured and modeled radiometric fluxes in the Arctic during FIRE-ACE, presented as a poster at the American Geophysical Union meeting, San Francisco, CA, Dec. 13-17, 1999. Pope, S.K., and F.P.J. Valero, Measured and modeled radiometric fluxes in the Arctic

  15. Overview of ASDEX Upgrade results

    NASA Astrophysics Data System (ADS)

    Gruber, O.; Arslanbekov, R.; Atanasiu, C.; Bard, A.; Becker, G.; Becker, W.; Beckmann, M.; Behler, K.; Behringer, K.; Bergmann, A.; Bilato, R.; Bolshukin, D.; Borrass, K.; Bosch, H.-S.; Braams, B.; Brambilla, M.; Brandenburg, R.; Braun, F.; Brinkschulte, H.; Brückner, R.; Brüsehaber, B.; Büchl, K.; Buhler, A.; Bürbaumer, H.; Carlson, A.; Ciric, M.; Conway, G.; Coster, D. P.; Dorn, C.; Drube, R.; Dux, R.; Egorov, S.; Engelhardt, W.; Fahrbach, H.-U.; Fantz, U.; Faugel, H.; Foley, M.; Franzen, P.; Fu, P.; Fuchs, J. C.; Gafert, J.; Gantenbein, G.; Gehre, O.; Geier, A.; Gernhardt, J.; Gubanka, E.; Gude, A.; Günter, S.; Haas, G.; Hartmann, D.; Heinemann, B.; Herrmann, A.; Hobirk, J.; Hofmeister, F.; Hohenöcker, H.; Horton, L.; Hu, L.; Jacobi, D.; Jakobi, M.; Jenko, F.; Kallenbach, A.; Kardaun, O.; Kaufmann, M.; Kendl, A.; Kim, J.-W.; Kirov, K.; Kochergov, R.; Kollotzek, H.; Kraus, W.; Krieger, K.; Kurzan, B.; Kyriakakis, G.; Lackner, K.; Lang, P. T.; Lang, R. S.; Laux, M.; Lengyel, L.; Leuterer, F.; Lorenz, A.; Maier, H.; Mank, K.; Manso, M.-E.; Maraschek, M.; Mast, K.-F.; McCarthy, P. J.; Meisel, D.; Meister, H.; Meo, F.; Merkel, R.; Mertens, V.; Meskat, J. P.; Monk, R.; Müller, H. W.; Münich, M.; Murmann, H.; Neu, G.; Neu, R.; Neuhauser, J.; Noterdaeme, J.-M.; Nunes, I.; Pautasso, G.; Peeters, A. G.; Pereverzev, G.; Pinches, S.; Poli, E.; Pugno, R.; Raupp, G.; Ribeiro, T.; Riedl, R.; Riondato, S.; Rohde, V.; Röhr, H.; Roth, J.; Ryter, F.; Salzmann, H.; Sandmann, W.; Sarelma, S.; Schade, S.; Schilling, H.-B.; Schlögl, D.; Schmidtmann, K.; Schneider, R.; Schneider, W.; Schramm, G.; Schweinzer, J.; Schweizer, S.; Scott, B. D.; Seidel, U.; Serra, F.; Sesnic, S.; Sihler, C.; Silva, A.; Sips, A.; Speth, E.; Stäbler, A.; Steuer, K.-H.; Stober, J.; Streibl, B.; Strumberger, E.; Suttrop, W.; Tabasso, A.; Tanga, A.; Tardini, G.; Tichmann, C.; Treutterer, W.; Troppmann, M.; Tsois, N.; Ullrich, W.; Ulrich, M.; Varela, P.; Vollmer, O.; Wenzel, U.; Wesner, F.; Wolf, R.; Wolfrum, E.; Wunderlich, R.; Xantopoulos, N.; Yu, Q.; Zarrabian, M.; Zasche, D.; Zehetbauer, T.; Zehrfeld, H.-P.; Zeiler, A.; Zohm, H.

    2001-10-01

    Ion and electron temperature profiles in conventional L and H mode on ASDEX Upgrade are generally stiff and limited by a critical temperature gradient length ∇T/T as given by ion temperature gradient (ITG) driven turbulence. ECRH experiments indicate that electron temperature (Te) profiles are also stiff, as predicted by electron temperature gradient turbulence with streamers. Accordingly, the core and edge temperatures are proportional to each other and the plasma energy is proportional to the pedestal pressure for fixed density profiles. Density profiles are not stiff, and confinement improves with density peaking. Medium triangularity shapes (δ<0.45) show strongly improved confinement up to the Greenwald density nGW and therefore higher βvalues, owing to increasing pedestal pressure, and H mode density operation extends above nGW. Density profile peaking at nGW was achieved with controlled gas puffing rates, and first results from a new high field side pellet launcher allowing higher pellet velocities are promising. At these high densities, small type II ELMs provide good confinement with low divertor power loading. In advanced scenarios the highest performance was achieved in the improved H mode with HL-89PβN approx 7.2 at δ = 0.3 for five confinement times, limited by neoclassical tearing modes (NTMs) at low central magnetic shear (qmin approx 1). The T profiles are still governed by ITG and trapped electron mode (TEM) turbulence, and confinement is improved by density peaking connected with low magnetic shear. Ion internal transport barrier (ITB) discharges - mostly with reversed shear (qmin>1) and L mode edge - achieved HL-89P <= 2.1 and are limited to βN <= 1.7 by internal and external ideal MHD modes. Turbulence driven transport is suppressed, in agreement with the E × B shear flow paradigm, and core transport coefficients are at the neoclassical ion transport level, where the latter was established by Monte Carlo simulations. Reactor relevant ion

  16. Recent Opportunity Microscopic Imager Results

    NASA Astrophysics Data System (ADS)

    Herkenhoff, K. E.; Arvidson, R. E.; Jolliff, B. L.; Yingst, R.; Team, A.

    2013-12-01

    Opportunity. The extremely soft bedrock exposed at a Whitewater Lake outcrop target dubbed 'Azilda' is mostly fine-grained, with dispersed 2-5 mm-diameter spherules and resistant veins. This target was easily abraded by the RAT, exposing a sandstone-like texture, but the sorting of grains is difficult to determine at MI resolution. Darker, erosion-resistant veneers, similar to desert varnishes on Earth, appear to record aqueous alteration that post-dates the formation of the Ca sulfate veins; they likely contain the nontronite that is observed by CRISM in this area. The inferred neutral pH and relatively low temperature of the fluids involved in these phases of alteration would have provided a habitable environment for life if it existed on Mars at that time. Because Opportunity can no longer directly sense phyllosilicate mineralogy with the MiniTES or Mössbauer spectrometers, it is focusing on characterizing the chemistry with the APXS and texture with the MI of potential phyllosilicate host rocks. The Athena MI continues to return useful images of Mars that are being used to study the textures of rocks and soils at Endeavour crater. Exploration by Opportunity continues, with the rover approaching 'Solander Point' and more exposures of phyllosilicates detected from orbit; the latest MI results will be presented at the conference.

  17. An overview of KSTAR results

    NASA Astrophysics Data System (ADS)

    Kwak, Jong-Gu; Oh, Y. K.; Yang, H. L.; Park, K. R.; Kim, Y. S.; Kim, W. C.; Kim, J. Y.; Lee, S. G.; Na, H. K.; Kwon, M.; Lee, G. S.; Ahn, H. S.; Ahn, J.-W.; Bae, Y. S.; Bak, J. G.; Bang, E. N.; Chang, C. S.; Chang, D. H.; Chen, Z. Y.; Cho, K. W.; Cho, M. H.; Choi, M.; Choe, W.; Choi, J. H.; Chu, Y.; Chung, K. S.; Diamond, P.; Delpech, L.; Do, H. J.; Eidietis, N.; England, A. C.; Ellis, R.; Evans, T.; Choe, G.; Grisham, L.; Gorelov, Y.; Hahn, H. S.; Hahn, S. H.; Han, W. S.; Hatae, T.; Hillis, D.; Hoang, T.; Hong, J. S.; Hong, S. H.; Hong, S. R.; Hosea, J.; Humphreys, D.; Hwang, Y. S.; Hyatt, A.; Ida, K.; In, Y. K.; Ide, S.; Jang, Y. B.; Jeon, Y. M.; Jeong, J. I.; Jeong, N. Y.; Jeong, S. H.; Jin, J. K.; Joung, M.; Ju, J.; Kawahata, K.; Kim, C. H.; Kim, Hee-Su; Kim, H. S.; Kim, H. J.; Kim, H. K.; Kim, H. T.; Kim, J. H.; Kim, J.; Kim, J. C.; Kim, Jong-Su; Kim, Jung-Su; Kim, J. H.; Kim, Kyung-Min; Kim, K. J.; Kim, K. P.; Kim, M. K.; Kim, S. T.; Kim, S. W.; Kim, Y. J.; Kim, Y. K.; Kim, Y. O.; Ko, J. S.; Ko, W. H.; Kogi, Y.; Kolemen, E.; Kong, J. D.; Kwak, S. W.; Kwon, J. M.; Kwon, O. J.; Lee, D. G.; Lee, D. R.; Lee, D. S.; Lee, H. J.; Lee, J.; Lee, J. H.; Lee, K. D.; Lee, K. S.; Lee, S. H.; Lee, S. I.; Lee, S. M.; Lee, T. G.; Lee, W.; Lee, W. L.; Lim, D. S.; Litaudon, X.; Lohr, J.; Mueller, D.; Moon, K. M.; Na, D. H.; Na, Y. S.; Nam, Y. U.; Namkung, W.; Narihara, K.; Oh, S. T.; Oh, D. G.; Ono, T.; Park, B. H.; Park, D. S.; Park, G. Y.; Park, H.; Park, H. T.; Park, J. K.; Park, J. S.; Park, M. K.; Park, S. H.; Park, S.; Park, Y. M.; Park, Y. S.; Parker, R.; Rhee, D. R.; Sabbagh, S. A.; Sakamoto, K.; Shiraiwa, S.; Seo, D. C.; Seo, S. H.; Seol, J. C.; Shi, Y. J.; Son, S. H.; Song, N. H.; Suzuki, T.; Terzolo, L.; Walker, M.; Wallace, G.; Watanabe, K.; Wang, S. J.; Woo, H. J.; Woo, I. S.; Yagi, M.; Yu, Y. W.; Yamada, I.; Yonekawa, Y.; Yoo, C. M.; You, K. I.; Yoo, J. W.; Yun, G. S.; Yu, M. G.; Yoon, S. W.; Xiao, W.; Zoletnik, S.; the KSTAR Team

    2013-10-01

    Since the first H-mode discharges in 2010, the duration of the H-mode state has been extended and a significantly wider operational window of plasma parameters has been attained. Using a second neutral beam (NB) source and improved tuning of equilibrium configuration with real-time plasma control, a stored energy of Wtot ˜ 450 kJ has been achieved with a corresponding energy confinement time of τE ˜ 163 ms. Recent discharges, produced in the fall of 2012, have reached plasma βN up to 2.9 and surpassed the n = 1 ideal no-wall stability limit computed for H-mode pressure profiles, which is one of the key threshold parameters defining advanced tokamak operation. Typical H-mode discharges were operated with a plasma current of 600 kA at a toroidal magnetic field BT = 2 T. L-H transitions were obtained with 0.8-3.0 MW of NB injection power in both single- and double-null configurations, with H-mode durations up to ˜15 s at 600 kA of plasma current. The measured power threshold as a function of line-averaged density showed a roll-over with a minimum value of ˜0.8 MW at \\bar{n}_e\\sim 2\\times 10^{19}\\,m^{-3} . Several edge-localized mode (ELM) control techniques during H-mode were examined with successful results including resonant magnetic perturbation, supersonic molecular beam injection (SMBI), vertical jogging and electron cyclotron current drive injection into the pedestal region. We observed various ELM responses, i.e. suppression or mitigation, depending on the relative phase of in-vessel control coil currents. In particular, with the 90° phase of the n = 1 RMP as the most resonant configuration, a complete suppression of type-I ELMs was demonstrated. In addition, fast vertical jogging of the plasma column was also observed to be effective in ELM pace-making. SMBI-mitigated ELMs, a state of mitigated ELMs, were sustained for a few tens of ELM periods. A simple cellular automata (‘sand-pile’) model predicted that shallow deposition near the pedestal

  18. SMOS first results over land

    NASA Astrophysics Data System (ADS)

    Kerr, Yann; Waldteufel, Philippe; Cabot, François; Richaume, Philippe; Jacquette, Elsa; Bitar, Ahmad Al; Mamhoodi, Ali; Delwart, Steven; Wigneron, Jean-Pierre

    2010-05-01

    retrieve soil moisture over fairly large and thus inhomogeneous areas. The retrieval is carried out at nodes of a fixed Earth surface grid. To achieve this purpose, after checking input data quality and ingesting auxiliary data, the retrieval process per se can be initiated. This cannot be done blindly as the direct model will be dependent upon surface characteristics. It is thus necessary to first assess what is the dominant land use of a node. For this, an average weighing function (MEAN_WEF) which takes into account the "antenna"pattern is run over the high resolution land use map to assess the dominant cover type. This is used to drive the decision tree which, step by step, selects the type of model to be used as per surface conditions. All this being said and done the retrieval procedure starts if all the conditions are satisfied, ideally to retrieve 3 parameters over the dominant class (the so-called rich retrieval). If the algorithm does not converge satisfactorily, a new trial is made with less floating parameters ("poorer retrieval") until either results are satisfactory or the algorithm is considered to fail. The retrieval algorithm also delivers whenever possible a dielectric constant parameter (using the-so called cardioid approach). Finally, once the retrieval converged, it is possible to compute the brightness temperature at a given fixed angle (42.5°) using the selected forward models applied to the set of parameters obtained at the end of the retrieval process. So the output product of the level 2 soil moisture algorithm should be node position, soil moisture, dielectric constants, computed brightness temperature at 42.5°, flags and quality indices. During the presentation we will describe in more details the algorithm and accompanying work in particular decision tree principle and characteristics, the auxiliary data used and the special and "exotic"cases. We will also be more explicit on the algorithm validation and verification through the data

  19. Recent results from the Microscopic Imagers on the Mars Exploration Rovers

    NASA Astrophysics Data System (ADS)

    Herkenhoff, K. E.; Ashley, J. W.; Cabrol, N. A.

    2009-12-01

    The Athena science payload on the Mars Exploration Rovers (MER) includes the Microscopic Imager (MI), designed to simulate a geologist’s hand lens. The fixed-focus MI is mounted on the instrument arm and can resolve objects 0.1 mm in size or larger. Spirit MI observations of the rocks on “Home Plate” continue to be consistent with a volcaniclastic origin. A total of 124 individual soil samples were analyzed using MI images acquired between landing and Sol 1980, including 28 bedforms, 35 composite soils, 49 unstructured soils, and 6 trenches including natural vertical exposures and those dug by Spirit’s wheels. Six outcrops and rocks were also analyzed as plausible source areas for the spherules and other particles observed in the soil around Home Plate, or when associated with large patches of soils. The rocks on Home Plate were covered by enough dust that RAT brushing was required to allow textures to be seen by the MI, such as the dark, moderately sorted and rounded grains (lapilli?) of the rock “Pecan Pie.” The MI also monitored the MER magnets and solar panels at the 2008 winter haven on the north side of Home Plate. After solar power was sufficient to allow Spirit to drive again, the MI was used to examine the silica-rich rock “Stapledon” just north of Home Plate. The texture of Stapledon appears similar to that seen in the silica-rich rocks on the east side of Home Plate, suggestive of secondary mineralization through precipitation from hydrothermal fluids. While plans for extracting Spirit from the sands of “Troy” are being made, the MI has been extensively used to examine the rocks and soils accessible to the instrument arm. These data show that moderately sorted, salty aggregate soils at depth are overlain by a thin crust near the present surface. These observations, along with MI images showing Spirit’s underbelly, are being used to inform extraction testing in the MER testbed at JPL. While the MI was not designed to take images of

  20. Use of Synthetic Derivatives To Determine the Minimal Active Structure of Cytokine-Inducing Lipoteichoic Acid▿

    PubMed Central

    Deininger, Susanne; Figueroa-Perez, Ignacio; Sigel, Stefanie; Stadelmaier, Andreas; Schmidt, Richard R.; Hartung, Thomas; von Aulock, Sonja

    2007-01-01

    Lipoteichoic acid (LTA) from gram-positive bacteria is the counterpart to lipopolysaccharide from gram-negative bacteria. LTA, which activates Toll-like receptor 2 (TLR2), induces a unique cytokine and chemokine pattern. The chemical synthesis of LTA proved its immunostimulatory properties. To determine the minimal active structure of LTA, we reduced synthetic LTA in a number of steps down to the synthetic anchor and employed these molecules to stimulate interleukin-8 (IL-8) release in human whole blood. Ten times more of the synthetic structures with four to six d-alanine-substituted polyglycerophosphate units (50 nM) than of the native LTA preparation was required to induce IL-8 release. A further reduction to three backbone units with two or no d-alanine residues resulted in cytokine induction only from 500 nM. The synthetic anchor was not able to induce IL-8 release even at 5 μM. When the LTA derivatives were used at 500 nM, they induced increasing levels of IL-8 and tumor necrosis factor alpha with increasing elongation of the backbone. Peritoneal macrophages were less responsive than human blood to the synthetic structures. Therefore, TLR2 dependency could be shown only with cells from TLR2-deficient mice for the two largest synthetic structures. This was confirmed by using TLR2-transfected HEK 293 cells. Taken together, these data indicate that although the synthetic anchor (which, unlike the native anchor, contains only myristic acid) cannot induce cytokine release, the addition of three backbone units, even without d-alanine substituents, confers this ability. Lengthening of the chain with d-alanine-substituted backbone units results in increased cytokine-inducing potency and a more sensitive response. PMID:17928431