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Sample records for lutetium 156

  1. Lutetium ultraphosphate.

    PubMed

    Horchani-Naifer, Karima; Férid, Mokhtar

    2008-05-10

    The structure of the title compound, LuP(5)O(14), comprises puckered eight-membered PO(4) rings linked by the lutetium cations in a complex way, forming a three-dimensional framework. Each eight-membered phosphate ring shares a bridging tetra-hedron with each of four adjacent tetra-hedra, to form layers of PO(4) tetra-hedra. These layers are c/2 in thickness and parallel to the ab plane. Each Lu ion is contained in one such layer, forming bonds to six O atoms in that layer and also to one O atom belonging to a tetra-hedron in each of the layers lying above and below it. The LuO(8) polyhedra are isolated from one another, since they share no common atoms. The Lu ions lie on twofold axes (special position 4e) and the shortest Lu⋯Lu distance is 5.703 (1) Å.

  2. Lutetium ultraphosphate

    PubMed Central

    Horchani-Naifer, Karima; Férid, Mokhtar

    2008-01-01

    The structure of the title compound, LuP5O14, comprises puckered eight-membered PO4 rings linked by the lutetium cations in a complex way, forming a three-dimensional framework. Each eight-membered phosphate ring shares a bridging tetra­hedron with each of four adjacent tetra­hedra, to form layers of PO4 tetra­hedra. These layers are c/2 in thickness and parallel to the ab plane. Each Lu ion is contained in one such layer, forming bonds to six O atoms in that layer and also to one O atom belonging to a tetra­hedron in each of the layers lying above and below it. The LuO8 polyhedra are isolated from one another, since they share no common atoms. The Lu ions lie on twofold axes (special position 4e) and the shortest Lu⋯Lu distance is 5.703 (1) Å. PMID:21202435

  3. Fermi surface measurements of lutetium

    NASA Astrophysics Data System (ADS)

    Johanson, W. R.; Crabtree, G. W.; Schmidt, F. A.

    1982-03-01

    We report de Haas-van Alphen (dHvA) measurements of the Fermi surface of lutetium at temperatures down to 0.3 K and in fields up to 150 kG in the (101¯0) and (112¯0) planes. Lutetium, having a filled 4f shell, serves as a nonmagnetic prototype of the structurally similar (hcp), trivalent, heavy rare earths from Gd to Tm. No complete frequency branches were observed, indicating that there are no closed pieces of surface. We observed all but one orbit predicted by relativistic-augmented-plane wave (RAPW) calculations of Keeton and Loucks, and the data support a geometry that is in good qualitative agreement with the existence of nested open electron and hole sheets.

  4. Fermi surface measurements of lutetium

    SciTech Connect

    Johanson, W.R.; Crabtree, G.W.; Schmidt, F.A.

    1982-03-01

    We report de Haas-van Alphen (dHvA) measurements of the Fermi surface of lutetium at temperatures down to 0.3 K and in fields up to 150 kG in the (1010) and (1120) planes. Lutetium, having a filled 4f shell, serves as a nonmagnetic prototype of the structurally similar (hcp), trivalent, heavy rare earths from Gd to Tm. No complete frequency branches were observed, indicating that there are no closed pieces of surface. We observed all but one orbit predicted by relativistic-augmented-plane wave (RAPW) calculations of Keeton and Loucks, and the data support a geometry that is in good qualitative agreement with the existence of nested open electron and hole sheets.

  5. Fermi surface measurements of lutetium

    SciTech Connect

    Johanson, W.R.; Crabtree, G.W.; Schmidt, F.A.

    1982-01-01

    We report de Haas-van Alphen (dHvA) measurements of the Fermi surface of Lutetium at temperatures down to .3K and in fields up to 150 kG in the (1010) and (1120) planes. Lutetium, having a filled 4f shell, serves as a non-magnetic prototype of the structurally similar (hcp), trivalent, heavy rare-earths from Gd to Tm. No complete frequency branches were observed, indicating that there are no closed pieces of surface. We observed all but one orbit predicted by relativistic-augmented-plane wave (RAPW) calculations of Keeton and Loucks, and the data support a geometry that is in good qualitative agreement with the existence of nested open electron and hole sheets.

  6. Selective photoionisation of lutetium isotopes

    SciTech Connect

    D'yachkov, Aleksei B; Kovalevich, S K; Labozin, Valerii P; Mironov, Sergei M; Panchenko, Vladislav Ya; Firsov, Valerii A; Tsvetkov, G O; Shatalova, G G

    2012-10-31

    A three-stage laser photoionisation scheme intended for enriching the {sup 176}Lu isotope from natural lutetium was considered. An investigation was made of the hyperfine structure of the second excited state 5d6s7s {yields} {sup 4}D{sub 3/2} with an energy of 37194 cm{sup -1} and the autoionisation state with an energy of 53375 cm{sup -1} of the {sup 176}Lu and {sup 175}Lu isotopes. The total electron momentum of the autoionisation level and the constant A of hyperfine magnetic interaction were determined. Due to a small value of the isotopic shift between {sup 176}Lu and {sup 175}Lu, appreciable selectivity of their separation may be achieved with individual hyperfine structure components. The first tentative enrichment of the 176Lu isotope was performed to a concentration of 60 % - 70 %. (laser applications and other topics in quantum electronics)

  7. Calibration of the lutetium-hafnium clock.

    PubMed

    Scherer, E; Munker, C; Mezger, K

    2001-07-27

    Well-defined constants of radioactive decay are the cornerstone of geochronology and the use of radiogenic isotopes to constrain the time scales and mechanisms of planetary differentiation. Four new determinations of the lutetium-176 decay constant (lambda176Lu) made by calibration against the uranium-lead decay schemes yield a mean value of 1.865 +/- 0.015 x 10(-11) year(-1), in agreement with the two most recent decay-counting experiments. Lutetium-hafnium ages that are based on the previously used lambda176Lu of 1.93 x 10(-11) to 1.94 x 10(-11) year(-1) are thus approximately 4% too young, and the initial hafnium isotope compositions of some of Earth's oldest minerals and rocks become less radiogenic relative to bulk undifferentiated Earth when calculated using the new decay constant. The existence of strongly unradiogenic hafnium in Early Archean and Hadean zircons implies that enriched crustal reservoirs existed on Earth by 4.3 billion years ago and persisted for 200 million years or more. Hence, current models of early terrestrial differentiation need revision.

  8. Lutetium oxide-based transparent ceramic scintillators

    DOEpatents

    Seeley, Zachary; Cherepy, Nerine; Kuntz, Joshua; Payne, Stephen A.

    2016-01-19

    In one embodiment, a transparent ceramic of sintered nanoparticles includes gadolinium lutetium oxide doped with europium having a chemical composition (Lu.sub.1-xGd.sub.x).sub.2-YEu.sub.YO.sub.3, where X is any value within a range from about 0.05 to about 0.45 and Y is any value within a range from about 0.01 to about 0.2, and where the transparent ceramic exhibits a transparency characterized by a scatter coefficient of less than about 10%/cm. In another embodiment, a transparent ceramic scintillator of sintered nanoparticles, includes a body of sintered nanoparticles including gadolinium lutetium oxide doped with a rare earth activator (RE) having a chemical composition (Lu.sub.1-xGd.sub.x).sub.2-YRE.sub.YO.sub.3, where RE is selected from the group consisting of: Sm, Eu, Tb, and Dy, where the transparent ceramic exhibits a transparency characterized by a scatter coefficient of less than about 10%/cm.

  9. Static and Dynamical Properties of heavy actinide Monopnictides of Lutetium.

    PubMed

    Mir, Showkat H; Jha, Prakash C; Islam, M S; Banarjee, Amitava; Luo, Wei; Dabhi, Shweta D; Jha, Prafulla K; Ahuja, R

    2016-07-07

    In this work, density functional theory within the framework of generalized gradient approximation has been used to investigate the structural, elastic, mechanical, and phonon properties of lutetium monopnictides in rock-salt crystal structure. The spin orbit coupling and Hubbard-U corrections are included to correctly predict the essential properties of these compounds. The elastic constants, Young's modulus E, Poisson's ratio v, shear modulus G, anisotropy factor A and Pugh's ratio are computed. We found that all lutetium monopnictides are anisotropic and show brittle character. From the wave velocities along [100], [110] and [111] directions, melting temperature of lutetium monopnictides are predicted. Dynamical stability of these monopnictides has been studied by density functional perturbation theory.

  10. Static and Dynamical Properties of heavy actinide Monopnictides of Lutetium

    PubMed Central

    Mir, Showkat H.; Jha, Prakash C.; Islam, M. S.; Banarjee, Amitava; Luo, Wei; Dabhi, Shweta D.; Jha, Prafulla K.; Ahuja, R.

    2016-01-01

    In this work, density functional theory within the framework of generalized gradient approximation has been used to investigate the structural, elastic, mechanical, and phonon properties of lutetium monopnictides in rock-salt crystal structure. The spin orbit coupling and Hubbard-U corrections are included to correctly predict the essential properties of these compounds. The elastic constants, Young’s modulus E, Poisson’s ratio v, shear modulus G, anisotropy factor A and Pugh’s ratio are computed. We found that all lutetium monopnictides are anisotropic and show brittle character. From the wave velocities along [100], [110] and [111] directions, melting temperature of lutetium monopnictides are predicted. Dynamical stability of these monopnictides has been studied by density functional perturbation theory. PMID:27384709

  11. Hydrothermal synthesis of lutetium disilicate nanoparticles

    SciTech Connect

    Tang Xiaoping; Gao Yanfeng; Chen Hongfei; Luo Hongjie

    2012-04-15

    A simple, low-cost hydrothermal method was developed to synthesize irregular-and rod-shaped lutetium disilicate (Lu{sub 2}Si{sub 2}O{sub 7}) powders with sizes ranging from 71 to 340 nm. The synthesis temperature was 260 Degree-Sign C, which is nearly 1300 Degree-Sign C lower than that required for the solid-state reaction. The results indicated that both the hydrothermal temperature and pH values had great influences on the composition, crystalline phase and morphology of the powders. The formation mechanism, basic thermophysical properties, stability and anticorrosion properties of the Lu{sub 2}Si{sub 2}O{sub 7} powders were also investigated. The obtained powders possessed low thermal conductivity, a suitable thermal expansion coefficient (3.92-5.17 Multiplication-Sign 10{sup -6} K{sup -1}) with the silicon-based substrate and excellent thermal and structural stability. During hot corrosion testing, the surfaces of the samples appeared to react with the water and molten salt vapors, but no serious failure occurred. - Graphical abstract: An image for the as-prepared Lu{sub 2}Si{sub 2}O{sub 7} powders (left) and XRD pattern (right) (inset shows the SEM graph of powders). Highlights: Black-Right-Pointing-Pointer We synthesized Lu{sub 2}Si{sub 2}O{sub 7} powders via a hydrothermal process at 260 Degree-Sign C. Black-Right-Pointing-Pointer Crystalline phase and morphology of the powders changed with experimental parameter. Black-Right-Pointing-Pointer Hot corrosion was determined in an airflow environment containing alkaline vapor.

  12. Discovery of gallium, germanium, lutetium, and hafnium isotopes

    SciTech Connect

    Gross, J.L.; Thoennessen, M.

    2012-09-15

    Currently, twenty-eight gallium, thirty-one germanium, thirty-five lutetium, and thirty-six hafnium isotopes have been observed and the discovery of these isotopes is described here. For each isotope a brief synopsis of the first refereed publication, including the production and identification method, is presented.

  13. Optical Response of Shocked Cerium-Doped Lutetium Oxyorthosilicate

    SciTech Connect

    G. D. Stevens

    2003-03-01

    Shock experiments were performed in order to characterize the triboluminescent signature of cerium-doped lutetium oxyorthosilicate (LSO:Ce). This material shows prompt, nano-second timescale light emission when driven by explosive detonation. When properly applied to a surface, it may be used as a shock arrival sensor, and also for imaging the propagation of a shock front. Triboluminescent rise times, spectral content, and spatial resolution measurements are presented.

  14. Evolving Important Role of Lutetium-177 for Therapeutic Nuclear Medicine.

    PubMed

    Pillai, Ambikalmajan M R; Knapp, Furn F Russ

    2015-01-01

    Lutetium-177 ((177)Lu) is a late entrant into the nuclear medicine therapy arena but is expected to become one of the most widely used therapeutic radionuclides. This paper analyses the reason for the increasing preference of (177)Lu as a therapeutic radionuclide. While the radionuclidic properties favor its use for several therapeutic applications, the potential for large scale production of (177)Lu is also an important aspect for its acceptability as a therapeutic radionuclide. This introductory discussion also summarizes some developing clinical uses and suggested future directions for applications of (177)Lu.

  15. Enhancement of lutetium texaphyrin phototherapy with Mitomycin C

    NASA Astrophysics Data System (ADS)

    Thiemann, Patricia A.; Woodburn, Kathryn W.

    1998-05-01

    Lutetium texaphyrin (Lu-Tex) photodynamic therapy (PDT) relies on the presence of the water-soluble Lu-Tex, oxygen, and light (activation around 730 nm). Cytotoxic oxygen species are produced that cause irreversible damage to biological substrates. Damage may be inflicted via direct cell kill mechanisms or through vasculature effects that cause hypoxia. The addition of hypoxia enhanced drugs, such as Mitomycin C (MMC), can potentially increase the anti-tumor response. RIF-1 bearing C3H mice received 10 micrometers ol Lu-Tex/kg and were illuminated with 100 J/cm2 3 hours postinjection. Mice received MMC (2.5 or 5 mg/kg, before and after light) in conjunction with PDT and were compared to subsets of drug alone controls. A significant improvement in PDT response was observed when MMC was added to the dosing regimen; the effect was more pronounced at the highest MMC dose of 5 mg/kg: MMC prior to PDT gave a median tumor regrowth time (10X original volume) of 28 days compared to MMC and PDT alone, 16.3 and 14.9 days, respectively. The anti-tumor activity of lutetium texaphyrin induced PDT was improved by the addition of the bioreductive alkylating agent mitomycin C.

  16. Electrochromic cells with lutetium diphthalocyanine and semisolid polymer electrolytes

    NASA Astrophysics Data System (ADS)

    Pizzarello, F. A.; Nicholson, M. M.

    1987-11-01

    Cyclic voltammograms were obtained for lutetium diphthalocyanine films in contact with plasticized poly(ethylene oxide) (PEO) electrolytes or solvent-swollen 2-acrylamido-2-methylpropane- sulfonic acid (AMPS) polymer electrolytes. Cells containing PEO-salt combinations plasticized with propylene glycol (PG) or acetonitrile resulted in slow, nonuniform color changes due to high interfacial resistance. The AMPS cell fabrication was simplified by starting with a commercial AMPS polymer product in the form of a transparent sheet containing water and other additives. This material, when further swollen in a PG-HC1 solution, produced the full range of uniform colors, accompanied by well defined voltammograms. It maintained good contact with the dye from -5 to 40 C.

  17. 40 CFR 156.156 - Residue removal instructions for refillable containers.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 24 2011-07-01 2011-07-01 false Residue removal instructions for refillable containers. 156.156 Section 156.156 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS LABELING REQUIREMENTS FOR PESTICIDES AND DEVICES Container Labeling § 156.156...

  18. Lutetium-methanediide-alkyl complexes: synthesis and chemistry.

    PubMed

    Li, Shihui; Wang, Meiyan; Liu, Bo; Li, Lei; Cheng, Jianhua; Wu, Chunji; Liu, Dongtao; Liu, Jingyao; Cui, Dongmei

    2014-11-17

    The first four-coordinate methanediide/alkyl lutetium complex (BODDI)Lu2 (CH2 SiMe3 )2 (μ2 -CHSiMe3 )(THF)2 (BODDI=ArNC(Me)CHCOCHC(Me)NAr, Ar=2,6-iPr2 C6 H3 ) (1) was synthesized by a thermolysis methodology through α-H abstraction from a Lu-CH2 SiMe3 group. Complex 1 reacted with equimolar 2,6-iPrC6 H3 NH2 and Ph2 C+O to give the corresponding lutetium bridging imido and oxo complexes (BODDI)Lu2 (CH2 SiMe3 )2 (μ2 -N-2,6-iPr2 C6 H3 )(THF)2 (2) and (BODDI)Lu2 (CH2 SiMe3 )2 (μ2 -O)(THF)2 (3). Treatment of 3 with Ph2 C=O (4 equiv) caused a rare insertion of Lu-μ2 -O bond into theC=O group to afford a diphenylmethyl diolate complex 4. Reaction of 1 with PhN=C=O (2 equiv) led to the migration of SiMe3 to the amido nitrogen atom to give complex (BODDI)Lu2 (CH2 SiMe3 )2 -μ-{PhNC(O)CHC(O)NPh(SiMe3 )-κ(3) N,O,O}(THF) (5). Reaction of 1 withtBuN=C formed an unprecedented product (BODDI)Lu2 (CH2 SiMe3 ){μ2 -[η(2) :η(2) -tBuN=C(=CH2 )SiMe2 CHC=NtBu-κ(1) N]}(tBuN=C)2 (6) through a cascade reaction of N=C bond insertion, sequential cyclometalative γ-(sp(3) )-H activation, C=C bond formation, and rearrangement of the newly formed carbene intermediate. The possible mechanistic pathways between 1, PhN=C=O, and tBuN=C were elucidated by DFT calculations. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  19. Octaoctyl-substituted lutetium bisphthalocyanine for NADH biosensing.

    PubMed

    Pal, C; Sharma, A K; Cammidge, A N; Cook, M J; Ray, A K

    2013-12-05

    Cyclic voltammetric and Raman and UV-vis spectroscopic measurements were performed on thin films of nonperipherally substituted bis[1,4,8,11,15,18,22,25-octakis(octyl)phthalocyaninato] lutetium(III) (R16LuPc2). Voltammograms exhibit one-electron quasi-reversible redox processes in 1.5 M LiClO4 aqueous solutions. The red-shift of the Q-band of R16LuPc2 in the UV-visible absorption spectra upon oxidation is attributed to the shortening of the inter-ring distance between the two phthalocyanine moieties. This observation is also consistent with the shift in the redox-sensitive vibrational modes in the Raman spectra due to the localization of the positive charge on phthalocyanine moieties. Neutralization of the oxidized R16LuPc2(+) film by dihydronicotinamide adenine dinucleotide (NADH) using different concentrations varying from 0.05 to 1 mM has been studied by UV-vis absorption and Raman spectroscopies. The reduction processes for a three month old film were found to be slower than those for freshly prepared films and showed a dependence upon NADH concentration. The data provide a basis for application of R16LuPc2 as a sensor for NADH.

  20. Theranostic Applications of Lutetium-177 in Radionuclide Therapy.

    PubMed

    Das, Tapas; Banerjee, Sharmila

    2016-01-01

    Lutetium-177 has been widely discussed as a radioisotope of choice for targeted radionuclide therapy. The simultaneous emission of imageable gamma photons [208 keV (11%) and 113 keV (6.4%)] along with particulate β(-) emission [β(max) = 497 keV] makes it a theranostically desirable radioisotope. In the present article, the possibility of using two 177Lu-based agents viz. 177Lu-EDTMP and 177Lu-DOTATATE for theranostic applications in metastatic bone pain palliation (MBPP) and peptide receptor radionuclide therapy (PRRT), have been explored. In the case of 177Lu-EDTMP, the whole-body images obtained are compared with those recorded using 99mTc-MDP in the same patient. On the other hand, pre-therapy images acquired with 177Lu-DOTA-TATE are compared with similar images obtained with standard agents, such as 99mTc-HYNIC-TOC (SPECT) and 68Ga-DOTA-TOC (PET) in the same patient. The advantage of the long physical half-life (T1/2) of 177Lu has been utilized in mapping the pharmacokinetics of two additional agents, 177Lu-labeled hydroxyapatite (HA) in radiation synovectomy of knee joints and 177Lu-HA for therapy of hepatocellular carcinoma. Results of these multiple studies conclusively document the potential of 177Lu as a theranostic radioisotope.

  1. Synthesis and densification of lutetium pyrosilicate from lutetia and silica

    SciTech Connect

    Tripathi, Himansu S.; Sarin, Vinod K. . E-mail: sarin@bu.edu

    2007-02-15

    Cerium-doped lutetium pyrosilicate (Lu{sub 2}Si{sub 2}O{sub 7}:Ce) powder was synthesized by solid state reaction of Lu{sub 2}O{sub 3} and SiO{sub 2}. Stoichiometric mixtures of the starting materials were heat treated at various different temperatures and their phase contents were measured by XRD technique. It was found that the first step in the formation of Lu{sub 2}Si{sub 2}O{sub 7} (LPS) is the appearance of Lu{sub 2}SiO{sub 5} (LSO). This takes place at 1100 deg. C, fully 300 deg. C below the first appearance of LPS. Between 1400 and 1500 deg. C both LSO and LPS coexist in the calcined batch, but by 1550 deg. C all LSO is completely converted to LPS. LPS formation temperature does not have appreciable effect on the density of the hot pressed samples. Hot pressed samples obtained from powder synthesized at 1650 deg. C are nearly transparent, although the particle size of the starting powder is higher than that of the powder formed at lower temperatures.

  2. A cascade reaction: ring-opening insertion of dioxaphospholane into lutetium alkyl bonds.

    PubMed

    Johnson, Kevin R D; Hayes, Paul G

    2014-02-14

    Geometrically constrained dioxaphospholane rings were incorporated into a bis(phosphinimine)carbazole ligand (HL) in an effort to generate an ancillary ligand system that is capable of supporting reactive lutetium alkyl functionalities and resistant to cyclometalation reactivity. This new ligand was used to prepare a lutetium dialkyl species, LLu(CH2SiMe3)2; however, the complex exhibited low thermal stability at ambient temperature. This dialkyl compound was found to be highly susceptible to a cascading inter- and intramolecular reaction that resulted in the sole formation of an asymmetric bimetallic tetraalkoxide complex. The product of this reaction, generated by the ring-opening insertion of dioxaphospholane moieties into lutetium-carbon bonds, was characterized by multinuclear NMR spectroscopy and single crystal X-ray diffraction.

  3. Lutetium-177 DOTATATE Production with an Automated Radiopharmaceutical Synthesis System.

    PubMed

    Aslani, Alireza; Snowdon, Graeme M; Bailey, Dale L; Schembri, Geoffrey P; Bailey, Elizabeth A; Pavlakis, Nick; Roach, Paul J

    2015-01-01

    Peptide Receptor Radionuclide Therapy (PRRT) with yttrium-90 ((90)Y) and lutetium-177 ((177)Lu)-labelled SST analogues are now therapy option for patients who have failed to respond to conventional medical therapy. In-house production with automated PRRT synthesis systems have clear advantages over manual methods resulting in increasing use in hospital-based radiopharmacies. We report on our one year experience with an automated radiopharmaceutical synthesis system. All syntheses were carried out using the Eckert & Ziegler Eurotope's Modular-Lab Pharm Tracer® automated synthesis system. All materials and methods used were followed as instructed by the manufacturer of the system (Eckert & Ziegler Eurotope, Berlin, Germany). Sterile, GMP-certified, no-carrier added (NCA) (177)Lu was used with GMP-certified peptide. An audit trail was also produced and saved by the system. The quality of the final product was assessed after each synthesis by ITLC-SG and HPLC methods. A total of 17 [(177)Lu]-DOTATATE syntheses were performed between August 2013 and December 2014. The amount of radioactive [(177)Lu]-DOTATATE produced by each synthesis varied between 10-40 GBq and was dependant on the number of patients being treated on a given day. Thirteen individuals received a total of 37 individual treatment administrations in this period. There were no issues and failures with the system or the synthesis cassettes. The average radiochemical purity as determined by ITLC was above 99% (99.8 ± 0.05%) and the average radiochemical purity as determined by HPLC technique was above 97% (97.3 ± 1.5%) for this period. The automated synthesis of [(177)Lu]-DOTATATE using Eckert & Ziegler Eurotope's Modular-Lab Pharm Tracer® system is a robust, convenient and high yield approach to the radiolabelling of DOTATATE peptide benefiting from the use of NCA (177)Lu and almost negligible radiation exposure of the operators.

  4. Magneto-optical property of terbium-lutetium-aluminum garnet crystals

    NASA Astrophysics Data System (ADS)

    Man, Peiwen; Ma, Fengkai; Xie, Tao; Ding, Jingxin; Wu, Anhua; Su, Liangbi; Li, Huanying; Ren, Guohao

    2017-04-01

    Mixed terbium lutetium aluminum garnet Tb2.2Lu0.8Al5O12 (LuTAG) single crystal was grown by Czochralski technique successfully. The structure had been analyzed by X-ray diffraction. The paramagnetic behavior was observed in magnetic measurement. Magneto-optical properties and thermal conductivity of LuTAG had been studied in detail and compared with these of TGG sample. The crystal exhibited a high thermal conductivity and very high transmittance, particularly in visible and near-infrared region, indicating terbium-lutetium-aluminum garnet could be a potential magneto-optical material using in high-power laser system.

  5. Lutetium-doped EuO films grown by molecular-beam epitaxy

    SciTech Connect

    Melville, A.; Heeg, T.; Mairoser, T.; Schmehl, A.; Shai, D. E.; Monkman, E. J.; Harter, J. W.; Hollaender, B.; Schubert, J.; Shen, K. M.; Mannhart, J.; Schlom, D. G.

    2012-05-28

    The effect of lutetium doping on the structural, electronic, and magnetic properties of epitaxial EuO thin films grown by reactive molecular-beam epitaxy is experimentally investigated. The behavior of Lu-doped EuO is contrasted with doping by lanthanum and gadolinium. All three dopants are found to behave similarly despite differences in electronic configuration and ionic size. Andreev reflection measurements on Lu-doped EuO reveal a spin-polarization of 96% in the conduction band, despite non-magnetic carriers introduced by 5% lutetium doping.

  6. Lutetium-177 DOTATATE Production with an Automated Radiopharmaceutical Synthesis System

    PubMed Central

    Aslani, Alireza; Snowdon, Graeme M; Bailey, Dale L; Schembri, Geoffrey P; Bailey, Elizabeth A; Pavlakis, Nick; Roach, Paul J

    2015-01-01

    Objective(s): Peptide Receptor Radionuclide Therapy (PRRT) with yttrium-90 (90Y) and lutetium-177 (177Lu)-labelled SST analogues are now therapy option for patients who have failed to respond to conventional medical therapy. In-house production with automated PRRT synthesis systems have clear advantages over manual methods resulting in increasing use in hospital-based radiopharmacies. We report on our one year experience with an automated radiopharmaceutical synthesis system. Methods: All syntheses were carried out using the Eckert & Ziegler Eurotope’s Modular-Lab Pharm Tracer® automated synthesis system. All materials and methods used were followed as instructed by the manufacturer of the system (Eckert & Ziegler Eurotope, Berlin, Germany). Sterile, GMP-certified, no-carrier added (NCA) 177Lu was used with GMP-certified peptide. An audit trail was also produced and saved by the system. The quality of the final product was assessed after each synthesis by ITLC-SG and HPLC methods. Results: A total of 17 [177Lu]-DOTATATE syntheses were performed between August 2013 and December 2014. The amount of radioactive [177Lu]-DOTATATE produced by each synthesis varied between 10-40 GBq and was dependant on the number of patients being treated on a given day. Thirteen individuals received a total of 37 individual treatment administrations in this period. There were no issues and failures with the system or the synthesis cassettes. The average radiochemical purity as determined by ITLC was above 99% (99.8 ± 0.05%) and the average radiochemical purity as determined by HPLC technique was above 97% (97.3 ± 1.5%) for this period. Conclusions: The automated synthesis of [177Lu]-DOTATATE using Eckert & Ziegler Eurotope’s Modular-Lab Pharm Tracer® system is a robust, convenient and high yield approach to the radiolabelling of DOTATATE peptide benefiting from the use of NCA 177Lu and almost negligible radiation exposure of the operators. PMID:27408890

  7. 45 CFR 156.947 - The record.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 1 2014-10-01 2014-10-01 false The record. 156.947 Section 156.947 Public Welfare... STANDARDS UNDER THE AFFORDABLE CARE ACT, INCLUDING STANDARDS RELATED TO EXCHANGES Administrative Review of QHP Issuer Sanctions in Federally-Facilitated Exchanges § 156.947 The record. (a) Any testimony that...

  8. 47 CFR 69.156 - Marketing expenses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 3 2010-10-01 2010-10-01 false Marketing expenses. 69.156 Section 69.156... Computation of Charges for Price Cap Local Exchange Carriers § 69.156 Marketing expenses. Effective July 1, 2000, the marketing expenses formerly allocated to the common line and traffic sensitive baskets, and...

  9. 47 CFR 69.156 - Marketing expenses.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 3 2011-10-01 2011-10-01 false Marketing expenses. 69.156 Section 69.156... Computation of Charges for Price Cap Local Exchange Carriers § 69.156 Marketing expenses. Effective July 1, 2000, the marketing expenses formerly allocated to the common line and traffic sensitive baskets, and...

  10. 40 CFR 205.156 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false 205.156 Section 205.156 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS TRANSPORTATION EQUIPMENT NOISE EMISSION CONTROLS Motorcycles § 205.156 ...

  11. 29 CFR 1915.156 - Foot protection.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... (PPE) § 1915.156 Foot protection. (a) Use. The employer shall ensure that each affected employee wears protective footwear when working in areas where there is a danger of foot injuries due to falling or rolling... 29 Labor 7 2010-07-01 2010-07-01 false Foot protection. 1915.156 Section 1915.156...

  12. 29 CFR 1915.156 - Foot protection.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... (PPE) § 1915.156 Foot protection. (a) Use. The employer shall ensure that each affected employee wears protective footwear when working in areas where there is a danger of foot injuries due to falling or rolling... 29 Labor 7 2011-07-01 2011-07-01 false Foot protection. 1915.156 Section 1915.156...

  13. 40 CFR 93.156 - Public participation.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 20 2011-07-01 2011-07-01 false Public participation. 93.156 Section 93.156 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED... General Federal Actions to State or Federal Implementation Plans § 93.156 Public participation. (a)...

  14. 29 CFR 1910.156 - Fire brigades.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... seconds, and the maximum char length shall be 4.0 inches (10.2 cm). (iii) When design of the fire... 29 Labor 5 2014-07-01 2014-07-01 false Fire brigades. 1910.156 Section 1910.156 Labor Regulations... OCCUPATIONAL SAFETY AND HEALTH STANDARDS Fire Protection § 1910.156 Fire brigades. (a) Scope and application—(1...

  15. 29 CFR 1910.156 - Fire brigades.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... seconds, and the maximum char length shall be 4.0 inches (10.2 cm). (iii) When design of the fire... 29 Labor 5 2011-07-01 2011-07-01 false Fire brigades. 1910.156 Section 1910.156 Labor Regulations... OCCUPATIONAL SAFETY AND HEALTH STANDARDS Fire Protection § 1910.156 Fire brigades. (a) Scope and application—(1...

  16. 40 CFR 156.159 - Compliance date.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 24 2011-07-01 2011-07-01 false Compliance date. 156.159 Section 156.159 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS LABELING REQUIREMENTS FOR PESTICIDES AND DEVICES Container Labeling § 156.159 Compliance date. Any pesticide product...

  17. 40 CFR 156.3 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 24 2011-07-01 2011-07-01 false Definitions. 156.3 Section 156.3 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS LABELING REQUIREMENTS FOR PESTICIDES AND DEVICES General Provisions § 156.3 Definitions. Terms used in this part have...

  18. 40 CFR 156.3 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 25 2012-07-01 2012-07-01 false Definitions. 156.3 Section 156.3 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS LABELING REQUIREMENTS FOR PESTICIDES AND DEVICES General Provisions § 156.3 Definitions. Terms used in this part have...

  19. 40 CFR 156.159 - Compliance date.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Compliance date. 156.159 Section 156.159 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS LABELING REQUIREMENTS FOR PESTICIDES AND DEVICES Container Labeling § 156.159 Compliance date. Any pesticide product...

  20. 40 CFR 156.159 - Compliance date.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 25 2012-07-01 2012-07-01 false Compliance date. 156.159 Section 156.159 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS LABELING REQUIREMENTS FOR PESTICIDES AND DEVICES Container Labeling § 156.159 Compliance date. Any pesticide product...

  1. 32 CFR 644.156 - Definition.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true Definition. 644.156 Section 644.156 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) REAL PROPERTY REAL ESTATE HANDBOOK Acquisition Acquisition of Rights-Of-Entry § 644.156 Definition. A right-of-entry is a bare...

  2. 45 CFR 156.925 - Motions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 1 2014-10-01 2014-10-01 false Motions. 156.925 Section 156.925 Public Welfare... QHP Issuer Sanctions in Federally-Facilitated Exchanges § 156.925 Motions. (a) Any request to the ALJ for an order or ruling must be by motion, stating the relief sought, the authority relied upon, and...

  3. 43 CFR 15.6 - Markers.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 1 2014-10-01 2014-10-01 false Markers. 15.6 Section 15.6 Public Lands: Interior Office of the Secretary of the Interior KEY LARGO CORAL REEF PRESERVE § 15.6 Markers. No person shall willfully mark, deface or injure in any way, or displace, remove or tamper with any Preserve...

  4. 43 CFR 15.6 - Markers.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 1 2013-10-01 2013-10-01 false Markers. 15.6 Section 15.6 Public Lands: Interior Office of the Secretary of the Interior KEY LARGO CORAL REEF PRESERVE § 15.6 Markers. No person shall willfully mark, deface or injure in any way, or displace, remove or tamper with any Preserve...

  5. 43 CFR 15.6 - Markers.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 1 2011-10-01 2011-10-01 false Markers. 15.6 Section 15.6 Public Lands: Interior Office of the Secretary of the Interior KEY LARGO CORAL REEF PRESERVE § 15.6 Markers. No person shall willfully mark, deface or injure in any way, or displace, remove or tamper with any Preserve...

  6. 43 CFR 15.6 - Markers.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 1 2012-10-01 2011-10-01 true Markers. 15.6 Section 15.6 Public Lands: Interior Office of the Secretary of the Interior KEY LARGO CORAL REEF PRESERVE § 15.6 Markers. No person shall willfully mark, deface or injure in any way, or displace, remove or tamper with any Preserve...

  7. 32 CFR 156.4 - Responsibilities.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false Responsibilities. 156.4 Section 156.4 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE SECURITY DEPARTMENT OF DEFENSE PERSONNEL SECURITY PROGRAM (DoDPSP) § 156.4 Responsibilities. (a) The Assistant Secretary of Defense for...

  8. 32 CFR 156.4 - Responsibilities.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 1 2013-07-01 2013-07-01 false Responsibilities. 156.4 Section 156.4 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE SECURITY DEPARTMENT OF DEFENSE PERSONNEL SECURITY PROGRAM (DoDPSP) § 156.4 Responsibilities. (a) The Assistant Secretary of Defense for...

  9. 40 CFR 205.156 - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 26 2013-07-01 2013-07-01 false 205.156 Section 205.156 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS TRANSPORTATION EQUIPMENT NOISE EMISSION CONTROLS Motorcycles § 205.156 ...

  10. 40 CFR 205.156 - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 25 2014-07-01 2014-07-01 false 205.156 Section 205.156 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS TRANSPORTATION EQUIPMENT NOISE EMISSION CONTROLS Motorcycles § 205.156 ...

  11. 40 CFR 205.156 - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 26 2012-07-01 2011-07-01 true 205.156 Section 205.156 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS TRANSPORTATION EQUIPMENT NOISE EMISSION CONTROLS Motorcycles § 205.156 ...

  12. 40 CFR 205.156 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 25 2011-07-01 2011-07-01 false 205.156 Section 205.156 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS TRANSPORTATION EQUIPMENT NOISE EMISSION CONTROLS Motorcycles § 205.156 ...

  13. 40 CFR 93.156 - Public participation.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 21 2013-07-01 2013-07-01 false Public participation. 93.156 Section 93.156 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED... General Federal Actions to State or Federal Implementation Plans § 93.156 Public participation. (a)...

  14. 40 CFR 93.156 - Public participation.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 20 2014-07-01 2013-07-01 true Public participation. 93.156 Section 93.156 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED... General Federal Actions to State or Federal Implementation Plans § 93.156 Public participation. (a)...

  15. 40 CFR 93.156 - Public participation.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 21 2012-07-01 2012-07-01 false Public participation. 93.156 Section 93.156 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED... General Federal Actions to State or Federal Implementation Plans § 93.156 Public participation. (a)...

  16. 21 CFR 156.145 - Tomato juice.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... capacity, except when the food is frozen. (2) Determine compliance as specified in § 156.3(d). (3) If the... 21 Food and Drugs 2 2014-04-01 2014-04-01 false Tomato juice. 156.145 Section 156.145 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR...

  17. 30 CFR 1218.156 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 3 2011-07-01 2011-07-01 false Definitions. 1218.156 Section 1218.156 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR Natural Resources..., Offshore § 1218.156 Definitions. Terms used in this subpart have the same meaning as in 30 U.S.C. 1702....

  18. 40 CFR 156.64 - Signal word.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 24 2014-07-01 2014-07-01 false Signal word. 156.64 Section 156.64... REQUIREMENTS FOR PESTICIDES AND DEVICES Human Hazard and Precautionary Statements § 156.64 Signal word. (a... signal word, reflecting the highest Toxicity Category (Category I is the highest toxicity category)...

  19. 47 CFR 69.156 - Marketing expenses.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 3 2013-10-01 2013-10-01 false Marketing expenses. 69.156 Section 69.156... Computation of Charges for Price Cap Local Exchange Carriers § 69.156 Marketing expenses. Effective July 1, 2000, the marketing expenses formerly allocated to the common line and traffic sensitive baskets,...

  20. 47 CFR 69.156 - Marketing expenses.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 3 2014-10-01 2014-10-01 false Marketing expenses. 69.156 Section 69.156... Computation of Charges for Price Cap Local Exchange Carriers § 69.156 Marketing expenses. Effective July 1, 2000, the marketing expenses formerly allocated to the common line and traffic sensitive baskets,...

  1. 47 CFR 69.156 - Marketing expenses.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 3 2012-10-01 2012-10-01 false Marketing expenses. 69.156 Section 69.156... Computation of Charges for Price Cap Local Exchange Carriers § 69.156 Marketing expenses. Effective July 1, 2000, the marketing expenses formerly allocated to the common line and traffic sensitive baskets,...

  2. 7 CFR 457.156 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false 457.156 Section 457.156 Agriculture Regulations of the Department of Agriculture (Continued) FEDERAL CROP INSURANCE CORPORATION, DEPARTMENT OF AGRICULTURE COMMON CROP INSURANCE REGULATIONS § 457.156 ...

  3. 43 CFR 15.6 - Markers.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Markers. 15.6 Section 15.6 Public Lands: Interior Office of the Secretary of the Interior KEY LARGO CORAL REEF PRESERVE § 15.6 Markers. No person shall willfully mark, deface or injure in any way, or displace, remove or tamper with any Preserve...

  4. 45 CFR 156.50 - Financial support.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 1 2012-10-01 2012-10-01 false Financial support. 156.50 Section 156.50 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS HEALTH... Provisions § 156.50 Financial support. (a) Definitions. The following definitions apply for the purposes...

  5. 45 CFR 156.50 - Financial support.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 1 2013-10-01 2013-10-01 false Financial support. 156.50 Section 156.50 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS HEALTH... Provisions § 156.50 Financial support. (a) Definitions. The following definitions apply for the purposes...

  6. 45 CFR 156.50 - Financial support.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 1 2014-10-01 2014-10-01 false Financial support. 156.50 Section 156.50 Public Welfare Department of Health and Human Services REQUIREMENTS RELATING TO HEALTH CARE ACCESS HEALTH... Provisions § 156.50 Financial support. (a) Definitions. The following definitions apply for the purposes...

  7. 29 CFR 1915.156 - Foot protection.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 7 2014-07-01 2014-07-01 false Foot protection. 1915.156 Section 1915.156 Labor... (PPE) § 1915.156 Foot protection. (a) Use. The employer shall ensure that each affected employee wears protective footwear when working in areas where there is a danger of foot injuries due to falling or...

  8. 29 CFR 1915.156 - Foot protection.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 7 2012-07-01 2012-07-01 false Foot protection. 1915.156 Section 1915.156 Labor... (PPE) § 1915.156 Foot protection. (a) Use. The employer shall ensure that each affected employee wears protective footwear when working in areas where there is a danger of foot injuries due to falling or...

  9. 29 CFR 1915.156 - Foot protection.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 7 2013-07-01 2013-07-01 false Foot protection. 1915.156 Section 1915.156 Labor... (PPE) § 1915.156 Foot protection. (a) Use. The employer shall ensure that each affected employee wears protective footwear when working in areas where there is a danger of foot injuries due to falling or...

  10. Novel lutetium spectroscopic interactions via cw RIMS (Resonance Ionization Mass Spectrometry)

    SciTech Connect

    Fearey, B.L.; Miller, C.M.

    1989-01-01

    Novel spectroscopic interactions of argon-ion laser enhanced resonance ionization of lutetium are observed and discussed; these include line-narrowing, non-linear power dependences and anomalous optical pumping effects of the hyperfine transitions. In addition, isotopically saturation dip spectra are observed and presented, allowing for precise determination of hyperfine constants of rare isotopes. 12 refs., 2 figs.

  11. de Haas--van Alphen effect and Fermi surface of lutetium

    SciTech Connect

    Johanson, W.R.; Crabtree, G.W.; Schmidt, F.A.

    1984-03-01

    We report de Haas--van Alphen measurements of the Fermi surface of lutetium at temperatures down to 0.3 K and in fields up to 150 kG in the (1010) and (1120) planes. Lutetium, having a filled 4f shell, serves as a nonmagnetic prototype of the structurally similar (hcp), trivalent, heavy rare-earth elements from Gd to Tm. The fact that no complete frequency branches were observed indicates that there are no closed pieces of the Fermi surface. We observed all but one orbit predicted by relativistic augmented-plane-wave calculations of Keeton and Loucks and by recent spin-orbit--linearized-augmented-plane-wave calculations of Tibbetts and Harmon. The data support a geometry similar to that of yttrium, and in good qualitative agreement with energy-band theory.

  12. de Haas-van Alphen effect and Fermi surface of lutetium

    NASA Astrophysics Data System (ADS)

    Johanson, W. R.; Crabtree, G. W.; Schmidt, F. A.

    1984-03-01

    We report de Haas-van Alphen measurements of the Fermi surface of lutetium at temperatures down to 0.3 K and in fields up to 150 kG in the (101¯0) and (112¯0) planes. Lutetium, having a filled 4f shell, serves as a nonmagnetic prototype of the structurally similar (hcp), trivalent, heavy rare-earth elements from Gd to Tm. The fact that no complete frequency branches were observed indicates that there are no closed pieces of the Fermi surface. We observed all but one orbit predicted by relativistic augmented-plane-wave calculations of Keeton and Loucks and by recent spin-orbit-linearized-augmented-plane-wave calculations of Tibbetts and Harmon. The data support a geometry similar to that of yttrium, and in good qualitative agreement with energy-band theory.

  13. Novel functionalized mesopore of SBA-15 as prospective sorbent for praseodymium and lutetium.

    PubMed

    Mallah, M H; Ghannadi Maragheh, M; Badiei, A; Habibzadeh Sbo, R

    In the present work, results of γ-irradiation on normal and functionalized SBA-15 by aurintricarboxylic acid have been reported. Characterization of normal and functionalized SBA-15 particles before and after γ-irradiation was carried out using Fourier-transform infrared technique. Aurintricarboxylic acid ligand connected to SBA-15 was also analyzed using UV/Vis spectrophotometer. The modified sorbent was then used as a new sorbent for separation of trace amounts of praseodymium and lutetium ions from nuclear waste waters in batch techniques. Based on the results of distribution coefficients determination, and investigation of sorption process in various conditions, the parameters were optimized for separation lanthanides. It can be concluded that the functionalized SBA-15 is a promising sorbent for praseodymium and lutetium cations.

  14. Heteroleptic naphthalo-phthalocyaninates of lutetium: synthesis and spectral and conductivity properties.

    PubMed

    Dubinina, Tatiana V; Kosov, Anton D; Petrusevich, Elizaveta F; Maklakov, Sergey S; Borisova, Nataliya E; Tomilova, Larisa G; Zefirov, Nikolay S

    2015-05-07

    Novel heteroleptic naphthalo-phthalocyaninates of lutetium possessing a symmetrical substituted naphthalocyanine deck were synthesized on the basis of two preformed synthetic blocks: naphthalocyanine ligand and lutetium phthalocyaninates. The compounds obtained were characterized by (1)H NMR and high-resolution MALDI-TOF/TOF mass spectrometry. The correlation between the nature of the substituents and the spectral properties of the target complexes was determined by the introduction of electron-donating (aryl-, aryloxy-) or electron-withdrawing (chloro-) substituents into the phthalocyanine deck. In addition, the nature of peripheral substituents was shown not to affect drastically the phthalocyanine conductivity and activation energy. Conductivity properties depend on thin film morphology which, in turn, relies on intermolecular π-π interactions.

  15. Properties of Ce-activated alkali-lutetium double phosphate scintillators

    SciTech Connect

    Wiśniewski, D.; Wojtowicz, A. J.; Boatner, Lynn A

    2010-01-01

    The scintillation properties of Ce-activated alkali-lutetium double phosphate single crystals that vary with the alkali ion type and activation level are summarized and compared. The materials investigated here have been identified as fast and efficient scintillators for the detection of x-ray and radiation, and in case of Li3Lu(PO4)2:Ce, for thermal neutron detection as well.

  16. Heat capacity and thermal expansion of icosahedral lutetium boride LuB66

    SciTech Connect

    Novikov, V V; Avdashchenko, D V; Matovnikov, A V; Mitroshenkov, N V; Bud’ko, S L

    2014-01-07

    The experimental values of heat capacity and thermal expansion for lutetium boride LuB66 in the temperature range of 2-300 K were analysed in the Debye-Einstein approximation. It was found that the vibration of the boron sub-lattice can be considered within the Debye model with high characteristic temperatures; low-frequency vibration of weakly connected metal atoms is described by the Einstein model.

  17. Lutetium(iii) aqua ion: On the dynamical structure of the heaviest lanthanoid hydration complex

    NASA Astrophysics Data System (ADS)

    Sessa, Francesco; Spezia, Riccardo; D'Angelo, Paola

    2016-05-01

    The structure and dynamics of the lutetium(iii) ion in aqueous solution have been investigated by means of a polarizable force field molecular dynamics (MD). An 8-fold square antiprism (SAP) geometry has been found to be the dominant configuration of the lutetium(iii) aqua ion. Nevertheless, a low percentage of 9-fold complexes arranged in a tricapped trigonal prism (TTP) geometry has been also detected. Dynamic properties have been explored by carrying out six independent MD simulations for each of four different temperatures: 277 K, 298 K, 423 K, 632 K. The mean residence time of water molecules in the first hydration shell at room temperature has been found to increase as compared to the central elements of the lanthanoid series in agreement with previous experimental findings. Water exchange kinetic rate constants at each temperature and activation parameters of the process have been determined from the MD simulations. The obtained structural and dynamical results suggest that the water exchange process for the lutetium(iii) aqua ion proceeds with an associative mechanism, in which the SAP hydration complex undergoes temporary structural changes passing through a 9-fold TTP intermediate. Such results are consistent with the water exchange mechanism proposed for heavy lanthanoid atoms.

  18. Lutetium(iii) aqua ion: On the dynamical structure of the heaviest lanthanoid hydration complex.

    PubMed

    Sessa, Francesco; Spezia, Riccardo; D'Angelo, Paola

    2016-05-28

    The structure and dynamics of the lutetium(iii) ion in aqueous solution have been investigated by means of a polarizable force field molecular dynamics (MD). An 8-fold square antiprism (SAP) geometry has been found to be the dominant configuration of the lutetium(iii) aqua ion. Nevertheless, a low percentage of 9-fold complexes arranged in a tricapped trigonal prism (TTP) geometry has been also detected. Dynamic properties have been explored by carrying out six independent MD simulations for each of four different temperatures: 277 K, 298 K, 423 K, 632 K. The mean residence time of water molecules in the first hydration shell at room temperature has been found to increase as compared to the central elements of the lanthanoid series in agreement with previous experimental findings. Water exchange kinetic rate constants at each temperature and activation parameters of the process have been determined from the MD simulations. The obtained structural and dynamical results suggest that the water exchange process for the lutetium(iii) aqua ion proceeds with an associative mechanism, in which the SAP hydration complex undergoes temporary structural changes passing through a 9-fold TTP intermediate. Such results are consistent with the water exchange mechanism proposed for heavy lanthanoid atoms.

  19. Biomimetic biosensor based on lipidic layers containing tyrosinase and lutetium bisphthalocyanine for the detection of antioxidants.

    PubMed

    Apetrei, C; Alessio, P; Constantino, C J L; de Saja, J A; Rodriguez-Mendez, M L; Pavinatto, F J; Ramos Fernandes, E Giuliani; Zucolotto, V; Oliveira, O N

    2011-01-15

    This paper describes the preparation of a biomimetic Langmuir-Blodgett film of tyrosinase incorporated in a lipidic layer and the use of lutetium bisphthalocyanine as an electron mediator for the voltammetric detection of phenol derivatives, which include one monophenol (vanillic acid), two diphenols (catechol and caffeic acid) and two triphenols (gallic acid and pyrogallol). The first redox process of the voltammetric responses is associated with the reduction of the enzymatically formed o-quinone and is favoured by the lutetium bisphthalocyanine because significant signal amplification is observed, while the second is associated with the electrochemical oxidation of the antioxidant and occurs at lower potentials in the presence of an electron mediator. The biosensor shows low detection limit (1.98×10(-6)-27.49×10(-6) M), good reproducibility, and high affinity to antioxidants (K(M) in the range of 62.31-144.87 μM). The excellent functionality of the enzyme obtained using a biomimetic immobilisation method, the selectivity afforded by enzyme catalysis, the signal enhancement caused by the lutetium bisphthalocyanine mediator and the increased selectivity of the curves due to the occurrence of two redox processes make these sensors exceptionally suitable for the detection of phenolic compounds. Copyright © 2010 Elsevier B.V. All rights reserved.

  20. Absolute peptide quantification by lutetium labeling and nanoHPLC-ICPMS with isotope dilution analysis.

    PubMed

    Rappel, Christina; Schaumlöffel, Dirk

    2009-01-01

    The need of analytical methods for absolute quantitative protein analysis spurred research on new developments in recent years. In this work, a novel approach was developed for accurate absolute peptide quantification based on metal labeling with lutetium diethylenetriamine pentaacetic acid (Lu-DTPA) and nanoflow high-performance liquid chromatography-inductively coupled plasma isotope dilution mass spectrometry (nanoHPLC-ICP-IDMS). In a two-step procedure peptides were derivatized at amino groups with diethylenetriamine pentaacetic anhydride (DTPAA) followed by chelation of lutetium. Electrospray ionization mass spectrometry (ESI MS) of the reaction product demonstrated highly specific peptide labeling. Under optimized nanoHPLC conditions the labeled peptides were baseline-separated, and the excess labeling reagent did not interfere. A 176Lu-labeled spike was continuously added to the column effluent for quantification by ICP-IDMS. The recovery of a Lu-DTPA-labeled standard peptide was close to 100% indicating high labeling efficiency and accurate absolute quantification. The precision of the entire method was 4.9%. The detection limit for Lu-DTPA-tagged peptides was 179 amol demonstrating that lutetium-specific peptide quantification was by 4 orders of magnitude more sensitive than detection by natural sulfur atoms present in cysteine or methionine residues. Furthermore, the application to peptides in insulin tryptic digest allowed the identification of interfering reagents decreasing the labeling efficiency. An additional advantage of this novel approach is the analysis of peptides, which do not naturally feature ICPMS-detectable elements.

  1. 18 CFR 156.10 - Hearings.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false Hearings. 156.10 Section 156.10 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT... protests or petitions to intervene, issue the requested order without hearing....

  2. 9 CFR 156.2 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Definitions. 156.2 Section 156.2 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... be construed, respectively, to mean: Administrator. The Administrator, Animal and Plant Health...

  3. 9 CFR 156.2 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Definitions. 156.2 Section 156.2 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... be construed, respectively, to mean: Administrator. The Administrator, Animal and Plant Health...

  4. 18 CFR 156.10 - Hearings.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 18 Conservation of Power and Water Resources 1 2014-04-01 2014-04-01 false Hearings. 156.10 Section 156.10 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT... earliest possible date giving due consideration of statutory requirements and other matters pending, with...

  5. 18 CFR 156.10 - Hearings.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Hearings. 156.10 Section 156.10 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT... earliest possible date giving due consideration of statutory requirements and other matters pending, with...

  6. 45 CFR 156.400 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... to the requirements of § 156.130(a). A standard plan at the bronze, silver, gold, or platinum level of coverage is referred to as a standard bronze plan, a standard silver plan, a standard gold plan... health plan as established in § 156.140(c). De minimis variation for a silver plan variation means a...

  7. 40 CFR 96.156 - Account error.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 21 2011-07-01 2011-07-01 false Account error. 96.156 Section 96.156 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NOX BUDGET TRADING PROGRAM AND CAIR NOX AND SO2 TRADING PROGRAMS FOR STATE IMPLEMENTATION PLANS CAIR NOX...

  8. 40 CFR 96.156 - Account error.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Account error. 96.156 Section 96.156 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NOX BUDGET TRADING PROGRAM AND CAIR NOX AND SO2 TRADING PROGRAMS FOR STATE IMPLEMENTATION PLANS CAIR NOX...

  9. 7 CFR 701.156 - Poultry.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 7 2013-01-01 2013-01-01 false Poultry. 701.156 Section 701.156 Agriculture... Poultry. (a) Subject to the other eligibility provisions of this part except as provided explicitly in... to a poultry house in an eligible county due to a 2005 hurricane. (b) Claimants under this section...

  10. 7 CFR 701.156 - Poultry.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 7 2012-01-01 2012-01-01 false Poultry. 701.156 Section 701.156 Agriculture... Poultry. (a) Subject to the other eligibility provisions of this part except as provided explicitly in... to a poultry house in an eligible county due to a 2005 hurricane. (b) Claimants under this section...

  11. 33 CFR 156.107 - Alternatives.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Alternatives. 156.107 Section 156....107 Alternatives. (a) The COTP may consider and approve alternative procedures, methods, or equipment... operator submits a written request for the alternative at least 30 days before operations under the...

  12. 18 CFR 156.10 - Hearings.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18 Conservation of Power and Water Resources 1 2013-04-01 2013-04-01 false Hearings. 156.10... GAS ACT § 156.10 Hearings. The Commission will schedule each application for public hearing at the... protests or petitions to intervene, issue the requested order without hearing. ...

  13. 21 CFR 156.3 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 2 2011-04-01 2011-04-01 false Definitions. 156.3 Section 156.3 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN...). For information on the availability of this material at NARA, call 202-741-6030, or go to: http://www...

  14. 21 CFR 156.3 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 2 2012-04-01 2012-04-01 false Definitions. 156.3 Section 156.3 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN...). For information on the availability of this material at NARA, call 202-741-6030, or go to: http://www...

  15. 27 CFR 28.156 - Losses.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Exportation or Transfer to a Foreign-Trade Zone § 28.156 Losses. Where there has been a loss of specially... or a foreign-trade zone, the exporter shall file claim for allowance of the loss in accordance with....156 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF...

  16. 27 CFR 28.156 - Losses.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Exportation or Transfer to a Foreign-Trade Zone § 28.156 Losses. Where there has been a loss of specially... or a foreign-trade zone, the exporter shall file claim for allowance of the loss in accordance with....156 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF...

  17. 27 CFR 28.156 - Losses.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Exportation or Transfer to a Foreign-Trade Zone § 28.156 Losses. Where there has been a loss of specially... or a foreign-trade zone, the exporter shall file claim for allowance of the loss in accordance with....156 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF...

  18. 27 CFR 28.156 - Losses.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Exportation or Transfer to a Foreign-Trade Zone § 28.156 Losses. Where there has been a loss of specially... or a foreign-trade zone, the exporter shall file claim for allowance of the loss in accordance with....156 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF...

  19. 27 CFR 28.156 - Losses.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Exportation or Transfer to a Foreign-Trade Zone § 28.156 Losses. Where there has been a loss of specially... or a foreign-trade zone, the exporter shall file claim for allowance of the loss in accordance with....156 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF...

  20. 30 CFR 1218.156 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 3 2014-07-01 2014-07-01 false Definitions. 1218.156 Section 1218.156 Mineral Resources OFFICE OF NATURAL RESOURCES REVENUE, DEPARTMENT OF THE INTERIOR NATURAL RESOURCES REVENUE COLLECTION OF ROYALTIES, RENTALS, BONUSES, AND OTHER MONIES DUE THE FEDERAL GOVERNMENT Oil, Gas and...

  1. 30 CFR 1218.156 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 3 2012-07-01 2012-07-01 false Definitions. 1218.156 Section 1218.156 Mineral Resources OFFICE OF NATURAL RESOURCES REVENUE, DEPARTMENT OF THE INTERIOR NATURAL RESOURCES REVENUE COLLECTION OF ROYALTIES, RENTALS, BONUSES, AND OTHER MONIES DUE THE FEDERAL GOVERNMENT Oil, Gas and...

  2. 30 CFR 1218.156 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 3 2013-07-01 2013-07-01 false Definitions. 1218.156 Section 1218.156 Mineral Resources OFFICE OF NATURAL RESOURCES REVENUE, DEPARTMENT OF THE INTERIOR NATURAL RESOURCES REVENUE COLLECTION OF ROYALTIES, RENTALS, BONUSES, AND OTHER MONIES DUE THE FEDERAL GOVERNMENT Oil, Gas and...

  3. 7 CFR 4280.156 - Liquidation.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Liquidation. 4280.156 Section 4280.156 Agriculture Regulations of the Department of Agriculture (Continued) RURAL BUSINESS-COOPERATIVE SERVICE AND RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE LOANS AND GRANTS Renewable Energy Systems and Energy...

  4. 46 CFR 160.156-1 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... APPROVAL LIFESAVING EQUIPMENT Rescue Boats and Fast Rescue Boats (SOLAS) § 160.156-1 Scope. This subpart... fast rescue boat, complying with SOLAS and the IMO LSA Code, for use on waters other than protected...

  5. 12 CFR 308.156 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... PROCEDURE Procedures and Standards Applicable to an Application Pursuant to Section 19 of the FDIA § 308.156..., who has been convicted of any criminal offense involving dishonesty or a breach of trust or...

  6. 40 CFR 156.64 - Signal word.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 25 2013-07-01 2013-07-01 false Signal word. 156.64 Section 156.64... (as distinct from skin and eye irritation), the word “Poison” must appear in red on a background of... “CAUTION.” (b) Use of signal words. In no case may a product: (1) Bear a signal word reflecting a...

  7. 40 CFR 156.64 - Signal word.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 25 2012-07-01 2012-07-01 false Signal word. 156.64 Section 156.64... (as distinct from skin and eye irritation), the word “Poison” must appear in red on a background of... “CAUTION.” (b) Use of signal words. In no case may a product: (1) Bear a signal word reflecting a...

  8. Synthesis of Lutetium Phosphate/Apoferritin Core-Shell Nanoparticles for Potential Applications in Radioimmunoimaging and Radioimmunotherapy of Cancers

    SciTech Connect

    Wu, Hong; Engelhard, Mark H.; Wang, Jun; Fisher, Darrell R.; Lin, Yuehe

    2008-04-01

    We report a novel approach for synthesizing LuPO4/apoferritin core-shell nanoparticles based on an apoferritin template, conjugated to the protein biotin. To prepare the nanoparticle conjugates, we used non-radioactive lutetium as a model target or surrogate for radiolutetium (177Lu). The central cavity, multi-channel structure, and chemical properties of apoferritin are well-suited for sequentially diffusing lutetium and phosphate ions into the cavity--resulting in a stable core-shell composite. We characterized the synthesized LuPO4/apoferritin nanoparticle using transmission electron microscopy (TEM) and x-ray photoelectron spectroscopy (XPS). We tested the pre-targeting capability of biotin-modified lutetium/apoferritin nanoparticle using streptavidin-modified magnetic beads and streptavidin-modified fluorescein isothiocyanate (FITC) tracer. This paper presents a simple, fast, and efficient method for synthesizing LuPO4/apoferritin nanoparticle conjugates with biotin for potential applications in radioimmunotherapy and radioimmunoimaging of cancer.

  9. Phase I trial of motexafin-lutetium-mediated interstitial photodynamic therapy in patients with locally recurrent prostate cancer

    NASA Astrophysics Data System (ADS)

    Stripp, Diana C. H.; Mick, Rosemarie; Zhu, Timothy C.; Whittington, Richard; Smith, Debbie; Dimofte, Andreea; Finlay, Jarod C.; Miles, Jeremy; Busch, Theresa M.; Shin, Daniel; Kachur, Alex; Tochner, Zelig A.; Malkowicz, S. Bruce; Glatstein, Eli; Hahn, Stephen M.

    2004-06-01

    Therapeutic options for patients with locally recurrent prostate cancer after treatment with radiation therapy are limited. An ongoing Phase I trial of interstitial photodynamic therapy (PDT) with the photosensitizer motexafin lutetium (MLu) was initiated in year 2000 for men with locally recurrent prostate cancer. The primary objective of this trial is to determine the maximally tolerated dose of motexafin lutetium-mediated PDT. Twelve men with biopsy-proven recurrent prostate cancer and no evidence of distant metastatic disease have been enrolled. Pre-treatment evaluation included an MRI of the prostate, bone scan, laboratory studies, cystoscopy, and transrectal ultrasound. Treatment plans were generated based upon the ultrasound findings. PDT dose was escalated by increasing the motexafin lutetium dose, increasing the 732 nm light dose, and decreasing the drug-light interval. Motexafin lutetium doses ranged from 0.5 to 2 mg/kg administered IV 3, 6, or 24 hours prior to 732 nm light delivery. The light dose measured in real time with in situ spherical detectors was 25-100 J/cm2 for all patients. Light was delivered through optical fibers inserted through a transperineal brachytherapy template in the operating room and optical property measurements were made before and after light therapy. Prostate biopsies were obtained before and after light delivery for spectrofluorometric measurements of photosensitizer uptake. Twelve patients have completed protocol treatment on eight dose levels without dose-limiting toxicity. Grade I PDT-related genitourinary symptoms were observed. One patient had Grade II urinary urgency that was urinary catheter-related. No rectal or other GI PDT-related toxicities were observed. Measurements of motexafin lutetium in prostate tissue demonstrated the presence of photosensitizer at all dose levels. Conclusions: Motexafin lutetium-mediated PDT designed to treat comprehensively the entired prostate gland has been well-tolerated at the doses

  10. Growth of epitaxial bismuth and gallium substituted lutetium iron garnet films by pulsed laser deposition

    SciTech Connect

    Leitenmeier, Stephan; Heinrich, Andreas; Lindner, Joerg K. N.; Stritzker, Bernd

    2006-04-15

    Epitaxial bismuth and gallium substituted lutetium iron garnet thin films have been grown on (100) oriented gadolinium gallium garnet Gd{sub 3}Ga{sub 5}O{sub 12} substrates by pulsed laser deposition. The films have been studied using x-ray diffraction, high resolution x-ray diffraction, Rutherford backscattering spectroscopy, transmission electron microscopy, and electron diffraction. We obtained smooth films with thicknesses between 0.3 and 1.0 {mu}m showing good crystalline quality and epitaxial growth.

  11. Syntheses and structures of mononuclear lutetium imido complexes with very short Lu-N bonds.

    PubMed

    Panda, Tarun K; Randoll, Sören; Hrib, Cristian G; Jones, Peter G; Bannenberg, Thomas; Tamm, Matthias

    2007-12-21

    The reaction of 1,3-bis(2,6-diisopropylphenyl)imidazolin-2-imine (ImDippNH) with trimethylsilylmethyllithium and anhydrous lutetium trichloride affords the imido complex [LuCl2(ImNDipp)(THF)3], which, on further reaction with dipotassium cyclooctatetraenide, K2(C8H8), leads to the half-sandwich cyclooctatetraenyl complex [(eta8-C8H8)Lu(ImNDipp)(THF)2]; both complexes contain very short Lu-N bond lengths, which are shorter than any previously reported Lu-N distances.

  12. Electrochromic and gas adsorption properties of Langmuir-Blodgett films of lutetium bisphthalocyanine complexes

    SciTech Connect

    Rodriguez-Mendez, M.L.; Aroca, R. ); DeSaja, J.A. )

    1993-07-01

    The electrochromic behaviour, spectroscopic properties and gas chemisorption of ultra thin films of lutetium octa-4-phenyldiphthalocyanine (LuPc[sub 2][sup Ph]), and the lutetium octa-3-bromo-octa-5-tert-butylphthalocyanine (LuPc[sub 2][sup tBr]) are reported. Electrochromism was observed for Langmuir-Blodgett (LB) and films cast onto indium tin oxide (ITO) coated glass electrodes in aqueous KClO[sub 4] solution. Mixed LB films supported on ITO glass electrodes were more stable to repetitive cycling than cast films. Films of LuPc[sub 2][sup Ph] and LuPc[sub 2][sup tBr] were sensitive to electron-acceptor gases as observed by the changes in the electronic absorption spectra and the surface-enhanced resonance Raman scattering (SERRS) spectra. The presence of electron-withdrawing bromine atoms in the phthalocyanine ring increased the rate of desorption for chemisorbed electron-acceptor molecules. 10 refs., 8 figs., 3 tabs.

  13. Lutetium(III) acetate phthalocyanines for photodynamic therapy applications: Synthesis and photophysicochemical properties.

    PubMed

    Mantareva, Vanya; Durmuş, Mahmut; Aliosman, Meliha; Stoineva, Ivanka; Angelov, Ivan

    2016-06-01

    The development of new water-soluble photosensitizers for photodynamic therapy (PDT) applications is a very active research topic. Efforts have been made to obtain the far-red absorbing phthalocyanine complexes with molecular design that facilitates the uptake and selectivity for a high PDT efficiency. The monomolecular lutetium(III) acetate phthalocyanines (LuPcs) substituted with methylpyridyloxy groups at non-peripheral (5) and peripheral (6) positions were synthesized by following the modification of the well-known synthetical routes. The photo-physicochemical properties of the both quaternized LuPcs were evaluated by the steady-state and time-resolved spectroscopy. The photochemical technique was applied to study the generation of the singlet oxygen. Two water-soluble and cationic LuPcs were synthesized and chemically characterized. The photo-physicochemical properties of absorption (675 and 685nm) and the red shifted fluorescence (704 and 721nm) as well as the fluorescence lifetimes (2.24 and 3.27ns) were studied. The promising values of singlet oxygen quantum yields (0.32 for 5 and 0.35 for 6) were determined. Lutetium(III) acetate phthalocyanine complexes were synthesized and evaluated with physicochemical properties suitable for future photodynamic therapy applications. Copyright © 2016 Elsevier B.V. All rights reserved.

  14. Two-level systems and negative thermal expansion of lutetium borides

    NASA Astrophysics Data System (ADS)

    Novikov, V. V.; Mitroshenkov, N. V.; Kornev, B. I.; Matovnikov, A. V.

    2017-05-01

    The heat capacity Cv(T) and unit cell volume V(T) temperature dependencies of lutetium borides LuB2 and LuB4 in the region of 2-300 K were analysed in the Debye-Einstein approximation. The characteristic temperatures of the Debye and Einstein components of boride heat capacity and thermal expansion were found. The anomalous contribution to the borides' thermal characteristics was revealed. This contribution was attributed to the influence of two-level systems (TLS), formed in the subsystem of lutetium ions due to asymmetry in the way they are surrounded by the boron atoms in the boride crystal structure. The TLS influence is revealed on heat capacity temperature dependencies by the Schottky-type maxima at Tmax LuB2 =13.8 K, Tmax LuB4 =22.7 K, as well as by the negative contribution to the borides' thermal expansion. The borides' Grüneisen parameters corresponding to the heat capacity and thermal expansion TLS anomalies are negative, and amount to several 10 s of units.

  15. Lutetium alkyl and hydride complexes in a non-cyclopentadienyl coordination environment.

    PubMed

    Konkol, Marcin; Spaniol, Thomas P; Kondracka, Małgorzata; Okuda, Jun

    2007-09-28

    Lutetium alkyl complexes [Lu(L)(CH(2)SiMe(3))(THF)(n)], which contain a sulfur-linked bis(phenolato) ligand such as 2,2'-thiobis(6-tert-butyl-4-methylphenolate) (L=tbmp, 1) or 1,4-dithiabutanediyl-bis(6-tert-butyl-4-methylphenolate) (L=etbmp, 2), were isolated from the reaction of the lutetium tris(alkyl) complex [Lu(CH(2)SiMe(3))(3)(THF)(2)] with H(2)L. The monomeric structures of these complexes were confirmed by X-ray diffraction studies, showing distorted octahedral geometry around the metal centre. The reaction of [Lu(tbmp)(CH(2)SiMe(3))(THF)(2)] (1) with alcohols ROH (R=iPr, CHPh(2), CPh(3)) results in the formation of the corresponding alkoxide complexes [Lu(tbmp)(OR)(THF)(n)] (4-6). With PhSiH(3) hydride complexes [Lu(L)(mu-H)(THF)(n)](2) (L=tbmp, 7; etbmp, 8) have been prepared in moderate to good yields. They adopt a dimeric form in the solid state as revealed by the X-ray crystal structure of 7. The reactivity of the hydride complexes and their catalytic activity in the ring-opening polymerisation of L-lactide and the hydrosilylation of alkenes are also discussed.

  16. On the photoelectron velocity-map imaging of lutetium monoxide anion LuO(-).

    PubMed

    Liu, Zhiling; Xie, Hua; Li, Quanjiang; Qin, Zhengbo; Cong, Ran; Wu, Xia; Tang, Zichao; Fan, Hongjun

    2014-01-21

    We report a combined photoelectron velocity-map imaging spectroscopy and density functional theory investigation on lutetium monoxide anion. Transition between the X (1)Σ(+) anion electronic ground state and the neutral X (2)Σ(+) electronic ground state is observed. Vibrationally resolved spectra were obtained at four different photon energies, providing a wealth of spectroscopic information for the electronic ground states of the anionic lutetium monoxide and corresponding neutral species. Franck-Condon simulations of the ground-state transition are performed to assign vibrational structure in the spectra and to assist in identifying the observed spectral bands. The electronic ground state of LuO(-) is found to have a vibrational frequency of 743 ± 10 cm(-1) and an equilibrium bond length of 1.841 Å. The electron affinity of LuO is measured to be 1.624 ± 0.002 eV. The fundamental frequency of ground-state LuO is estimated to be 839 ± 10 cm(-1).

  17. On the photoelectron velocity-map imaging of lutetium monoxide anion LuO{sup −}

    SciTech Connect

    Liu, Zhiling; Xie, Hua; Qin, Zhengbo; Cong, Ran; Wu, Xia; Tang, Zichao Fan, Hongjun; Li, Quanjiang

    2014-01-21

    We report a combined photoelectron velocity-map imaging spectroscopy and density functional theory investigation on lutetium monoxide anion. Transition between the X {sup 1}Σ{sup +} anion electronic ground state and the neutral X {sup 2}Σ{sup +} electronic ground state is observed. Vibrationally resolved spectra were obtained at four different photon energies, providing a wealth of spectroscopic information for the electronic ground states of the anionic lutetium monoxide and corresponding neutral species. Franck-Condon simulations of the ground-state transition are performed to assign vibrational structure in the spectra and to assist in identifying the observed spectral bands. The electronic ground state of LuO{sup −} is found to have a vibrational frequency of 743 ± 10 cm{sup −1} and an equilibrium bond length of 1.841 Å. The electron affinity of LuO is measured to be 1.624 ± 0.002 eV. The fundamental frequency of ground-state LuO is estimated to be 839 ± 10 cm{sup −1}.

  18. Lutetium texaphyrin (Lu-Tex): a potential new agent for ocular fundus angiography and photodynamic therapy.

    PubMed

    Blumenkranz, M S; Woodburn, K W; Qing, F; Verdooner, S; Kessel, D; Miller, R

    2000-03-01

    To investigate the suitability of lutetium texaphyrin (lu-tex) as a fluorescence imaging agent in the delineation of retinal vascular and choroidal vascular diseases. The utilization of an efficient fluorescent molecule that is also a photosensitizer represents a unique opportunity to couple diagnosis and therapy. Fundus fluorescence angiography comparing lu-tex (motexafin lutetium, Optrin, Pharmacyclics Inc, Sunnyvale, California) with the conventional angiographic dyes, sodium fluorescein, and indocynanine green (ICG), was performed on the eyes of normal and laser-injured New Zealand white rabbits. Plasma pharmacokinetic data and plasma protein binding were assessed in addition to light microscopy of the retina in both imaged and laser-injured eyes. Normal retinal and choroidal vasculature was well delineated by lu-tex angiography. Experimentally induced choroidal and retinal vascular lesions were enhanced by lu-tex and demonstrated different staining patterns than fluorescein or ICG, particularly at the margins of the lesions. Lu-tex cleared rapidly from the plasma, with 39.7% bound to the high-density lipoprotein (HDL) fraction while 15.8% was bound to the low-density lipoprotein (LDL) fraction. No evidence of retinal toxicity after dye administration was observed by either ophthalmoscopy and fundus photography or by light microscopy. Lu-tex angiography is a potentially valuable method for retinal vascular and choroidal vascular evaluation, and it has advantages over fluorescein and ICG angiography. The same agent could conceivably be used for both the identification of abnormal vasculature and subsequent photodynamic treatment.

  19. Atomic and electronic structures of lutetium oxide Lu{sub 2}O{sub 3}

    SciTech Connect

    Kaichev, V. V.; Asanova, T. I.; Erenburg, S. B.; Perevalov, T. V.; Shvets, V. A.; Gritsenko, V. A.

    2013-02-15

    The chemical composition, electronic structure, structure, and physical properties a lutetium oxide Lu{sub 2}O{sub 3} film are studied by X-ray photoelectron spectroscopy, ellipsometry, and X-ray absorption spectroscopy. The short-range order in Lu{sub 2}O{sub 3} is found to correspond to its cubic modification. The binding energies of the 1s and 2p levels of oxygen and the 4d{sub 5/2} and 4f{sub 7/2} levels of lutetium are 529.2, 5.0 and 7.4, 195.9 eV, respectively. The energy gap determined from the electron energy loss spectrum of the film is 5.9 eV. The electron energy loss spectra have two peaks at 17.4 and 22.0 eV, which can be attributed to the excitation of bulk plasma oscillations. The dispersion of the refractive index is measured by spectral ellipsometry. The refractive index is shown to increase from 1.82 at 1.5 eV to 2.18 at 5.0 eV, and the high-frequency permittivity of Lu{sub 2}O{sub 3} is 3.31.

  20. Inclusion complexes of trivalent lutetium cations with an acidic derivative of per(3,6-anhydro)-alpha-cyclodextrin.

    PubMed

    Bonnet, Célia; Gadelle, Andrée; Pécaut, Jacques; Fries, Pascal H; Delangle, Pascale

    2005-02-07

    The cyclodextrin derivative (hexakis (2-O-carboxymethyl-3,6-anhydro)-alpha-cyclodextrin) forms mono- and bimetallic complexes with lutetium(III) in aqueous solution; the X-ray structure of the binuclear complex [Lu2(ACX)(H2O)2] is the first example of a lanthanide-cyclodextrin inclusion complex.

  1. 45 CFR 400.156 - Service requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Public Welfare Regulations Relating to Public Welfare OFFICE OF REFUGEE RESETTLEMENT, ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES REFUGEE RESETTLEMENT PROGRAM Refugee Social Services Scope of Refugee Social Services § 400.156 Service requirements. (a) In order to...

  2. 45 CFR 400.156 - Service requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Public Welfare Regulations Relating to Public Welfare OFFICE OF REFUGEE RESETTLEMENT, ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES REFUGEE RESETTLEMENT PROGRAM Refugee Social Services Scope of Refugee Social Services § 400.156 Service requirements. (a) In order to...

  3. 50 CFR 300.156 - Prohibited acts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    .... Nationals Fishing in Russian Fisheries § 300.156 Prohibited acts. In addition to the prohibited acts... such vessel: (a) To fish for Russian fishery resources without a valid permit issued by the competent authorities of the Russian Federation. (b) To violate the provisions, conditions, and restrictions of an...

  4. 50 CFR 300.156 - Prohibited acts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    .... Nationals Fishing in Russian Fisheries § 300.156 Prohibited acts. In addition to the prohibited acts... such vessel: (a) To fish for Russian fishery resources without a valid permit issued by the competent authorities of the Russian Federation. (b) To violate the provisions, conditions, and restrictions of an...

  5. 40 CFR 156.206 - General statements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ....” This statement shall be under the heading AGRICULTURAL USE REQUIREMENTS in the labeling. (e) Spanish... to the criteria in § 156.62, the signal word shall appear in Spanish in addition to English followed... Spanish signal word “PELIGRO” shall be used for products in toxicity category I, and the Spanish signal...

  6. 50 CFR 300.156 - Prohibited acts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    .... Nationals Fishing in Russian Fisheries § 300.156 Prohibited acts. In addition to the prohibited acts... such vessel: (a) To fish for Russian fishery resources without a valid permit issued by the competent authorities of the Russian Federation. (b) To violate the provisions, conditions, and restrictions of...

  7. 50 CFR 300.156 - Prohibited acts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    .... Nationals Fishing in Russian Fisheries § 300.156 Prohibited acts. In addition to the prohibited acts... such vessel: (a) To fish for Russian fishery resources without a valid permit issued by the competent authorities of the Russian Federation. (b) To violate the provisions, conditions, and restrictions of...

  8. 50 CFR 300.156 - Prohibited acts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    .... Nationals Fishing in Russian Fisheries § 300.156 Prohibited acts. In addition to the prohibited acts... such vessel: (a) To fish for Russian fishery resources without a valid permit issued by the competent authorities of the Russian Federation. (b) To violate the provisions, conditions, and restrictions of...

  9. 40 CFR 156.60 - General.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... REQUIREMENTS FOR PESTICIDES AND DEVICES Human Hazard and Precautionary Statements § 156.60 General. Each product label is required to bear hazard and precautionary statements for humans and domestic animals (if... labeling. These include, but are not limited to, the human hazard and precautionary statements,...

  10. 40 CFR 156.60 - General.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... REQUIREMENTS FOR PESTICIDES AND DEVICES Human Hazard and Precautionary Statements § 156.60 General. Each product label is required to bear hazard and precautionary statements for humans and domestic animals (if... labeling. These include, but are not limited to, the human hazard and precautionary statements,...

  11. 40 CFR 156.60 - General.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... REQUIREMENTS FOR PESTICIDES AND DEVICES Human Hazard and Precautionary Statements § 156.60 General. Each product label is required to bear hazard and precautionary statements for humans and domestic animals (if... labeling. These include, but are not limited to, the human hazard and precautionary statements,...

  12. 40 CFR 82.156 - Required practices.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...) PROTECTION OF STRATOSPHERIC OZONE Recycling and Emissions Reduction § 82.156 Required practices. (a) All... recycling machine certified pursuant to § 82.158. All persons opening appliances except for MVACs and MVAC... remaining portions of the appliance, or a specific vessel within the appliance) or a recovery or recycling...

  13. 40 CFR 82.156 - Required practices.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...) PROTECTION OF STRATOSPHERIC OZONE Recycling and Emissions Reduction § 82.156 Required practices. (a) All... recycling machine certified pursuant to § 82.158. All persons opening appliances except for MVACs and MVAC... remaining portions of the appliance, or a specific vessel within the appliance) or a recovery or recycling...

  14. 40 CFR 82.156 - Required practices.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...) PROTECTION OF STRATOSPHERIC OZONE Recycling and Emissions Reduction § 82.156 Required practices. (a) All... recycling machine certified pursuant to § 82.158. All persons opening appliances except for MVACs and MVAC... remaining portions of the appliance, or a specific vessel within the appliance) or a recovery or recycling...

  15. 40 CFR 82.156 - Required practices.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...) PROTECTION OF STRATOSPHERIC OZONE Recycling and Emissions Reduction § 82.156 Required practices. (a) All... recycling machine certified pursuant to § 82.158. All persons opening appliances except for MVACs and MVAC... remaining portions of the appliance, or a specific vessel within the appliance) or a recovery or recycling...

  16. 40 CFR 82.156 - Required practices.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) PROTECTION OF STRATOSPHERIC OZONE Recycling and Emissions Reduction § 82.156 Required practices. (a) All... recycling machine certified pursuant to § 82.158. All persons opening appliances except for MVACs and MVAC... remaining portions of the appliance, or a specific vessel within the appliance) or a recovery or recycling...

  17. 45 CFR 156.420 - Plan variations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...-Sharing Reductions § 156.420 Plan variations. (a) Submission of silver plan variations. For each of its silver health plans that an issuer offers, or intends to offer in the individual market on an Exchange... standard silver plan and three variations of the standard silver plan, as follows— (1) For...

  18. 40 CFR 93.156 - Public participation.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... analytical methods and conclusions relied upon in making the applicability analysis and draft conformity... July 6, 2010. For the convenience of the user, the revised text is set forth as follows: § 93.156... methods and conclusions relied upon in making the applicability analysis and draft...

  19. 40 CFR 156.206 - General statements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ....” This statement shall be under the heading AGRICULTURAL USE REQUIREMENTS in the labeling. (e) Spanish... to the criteria in § 156.62, the signal word shall appear in Spanish in addition to English followed... Spanish signal word “PELIGRO” shall be used for products in toxicity category I, and the Spanish signal...

  20. 40 CFR 156.206 - General statements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ....” This statement shall be under the heading AGRICULTURAL USE REQUIREMENTS in the labeling. (e) Spanish... to the criteria in § 156.62, the signal word shall appear in Spanish in addition to English followed... Spanish signal word “PELIGRO” shall be used for products in toxicity category I, and the Spanish signal...

  1. 40 CFR 156.206 - General statements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ....” This statement shall be under the heading AGRICULTURAL USE REQUIREMENTS in the labeling. (e) Spanish... to the criteria in § 156.62, the signal word shall appear in Spanish in addition to English followed... Spanish signal word “PELIGRO” shall be used for products in toxicity category I, and the Spanish signal...

  2. 40 CFR 156.206 - General statements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ....” This statement shall be under the heading AGRICULTURAL USE REQUIREMENTS in the labeling. (e) Spanish... to the criteria in § 156.62, the signal word shall appear in Spanish in addition to English followed... Spanish signal word “PELIGRO” shall be used for products in toxicity category I, and the Spanish signal...

  3. 46 CFR 160.156-1 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... APPROVAL LIFESAVING EQUIPMENT Rescue Boats and Fast Rescue Boats (SOLAS) § 160.156-1 Scope. This subpart prescribes standards, tests, and procedures for seeking Coast Guard approval of a rescue boat, including a fast rescue boat, complying with SOLAS and the IMO LSA Code, for use on waters other than...

  4. 40 CFR 156.62 - Toxicity Category.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... REQUIREMENTS FOR PESTICIDES AND DEVICES Human Hazard and Precautionary Statements § 156.62 Toxicity Category... being the highest toxicity category. Most human hazard, precautionary statements, and human personal... days No corneal opacity; irritation reversible within 7 days No irritation Skin irritation Corrosive...

  5. 7 CFR 1789.156 - Proposal procedure.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... AGRICULTURE (CONTINUED) USE OF CONSULTANTS FUNDED BY BORROWERS Policy and Procedures With Respect to Consultant Services Funded by Borrowers-General § 1789.156 Proposal procedure. (a) In the event RUS determines that consideration should be given to the use of a Borrower-funded consultant in connection with...

  6. 7 CFR 1789.156 - Proposal procedure.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... AGRICULTURE (CONTINUED) USE OF CONSULTANTS FUNDED BY BORROWERS Policy and Procedures With Respect to Consultant Services Funded by Borrowers-General § 1789.156 Proposal procedure. (a) In the event RUS determines that consideration should be given to the use of a Borrower-funded consultant in connection with...

  7. 7 CFR 1789.156 - Proposal procedure.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... AGRICULTURE (CONTINUED) USE OF CONSULTANTS FUNDED BY BORROWERS Policy and Procedures With Respect to Consultant Services Funded by Borrowers-General § 1789.156 Proposal procedure. (a) In the event RUS determines that consideration should be given to the use of a Borrower-funded consultant in connection with...

  8. 7 CFR 1789.156 - Proposal procedure.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... AGRICULTURE (CONTINUED) USE OF CONSULTANTS FUNDED BY BORROWERS Policy and Procedures With Respect to Consultant Services Funded by Borrowers-General § 1789.156 Proposal procedure. (a) In the event RUS determines that consideration should be given to the use of a Borrower-funded consultant in connection with...

  9. 7 CFR 1789.156 - Proposal procedure.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... AGRICULTURE (CONTINUED) USE OF CONSULTANTS FUNDED BY BORROWERS Policy and Procedures With Respect to Consultant Services Funded by Borrowers-General § 1789.156 Proposal procedure. (a) In the event RUS determines that consideration should be given to the use of a Borrower-funded consultant in connection with...

  10. 46 CFR 160.156-1 - Scope.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... APPROVAL LIFESAVING EQUIPMENT Rescue Boats and Fast Rescue Boats (SOLAS) § 160.156-1 Scope. This subpart prescribes standards, tests, and procedures for seeking Coast Guard approval of a rescue boat, including a fast rescue boat, complying with SOLAS and the IMO LSA Code, for use on waters other than protected...

  11. 40 CFR 156.80 - General.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS LABELING REQUIREMENTS FOR PESTICIDES AND DEVICES Environmental Hazard and Precautionary Statements § 156.80 General. (a... to take to avoid the hazard or mitigate its effects. (b) Location of statements. Environmental...

  12. 40 CFR 156.80 - General.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS LABELING REQUIREMENTS FOR PESTICIDES AND DEVICES Environmental Hazard and Precautionary Statements § 156.80 General. (a... to take to avoid the hazard or mitigate its effects. (b) Location of statements. Environmental...

  13. 40 CFR 156.80 - General.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS LABELING REQUIREMENTS FOR PESTICIDES AND DEVICES Environmental Hazard and Precautionary Statements § 156.80 General. (a... to take to avoid the hazard or mitigate its effects. (b) Location of statements. Environmental...

  14. 40 CFR 156.80 - General.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS LABELING REQUIREMENTS FOR PESTICIDES AND DEVICES Environmental Hazard and Precautionary Statements § 156.80 General. (a... to take to avoid the hazard or mitigate its effects. (b) Location of statements. Environmental...

  15. 40 CFR 156.60 - General.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS LABELING REQUIREMENTS FOR PESTICIDES AND DEVICES Human Hazard and Precautionary Statements § 156.60 General. Each product label is required to bear hazard and precautionary statements for humans and domestic animals (if...

  16. 45 CFR 156.255 - Rating variations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS HEALTH INSURANCE ISSUER STANDARDS UNDER THE AFFORDABLE CARE ACT, INCLUDING STANDARDS RELATED TO EXCHANGES Qualified Health Plan Minimum Certification Standards § 156.255 Rating variations. (a) Rating areas. A QHP...

  17. 26 CFR 1.56(g)-0 - Table of Contents.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 1 2010-04-01 2010-04-01 true Table of Contents. 1.56(g)-0 Section 1.56(g)-0... Applicable to Taxable Years Beginning in 1969 and Ending in 1970 § 1.56(g)-0 Table of Contents. This section lists the paragraphs contained in § 1.56(g)-1. § 1.56(g)-1Adjusted current earnings. (a) Adjustment for...

  18. Photoelectric conversion and electrochromic properties of lutetium tetrakis(tert-butyl)bisphthalocyaninate

    SciTech Connect

    Hu, Andrew Teh; Hu Tenyi; Liu Lungchang

    2003-12-10

    Both photoelectric and electrochromic effects on lutetium tetrakis(tert-butyl)bisphthalocyaninate (Lu(TBPc){sub 2}) have been carried out in this study. Lu(TBPc){sub 2} is known for its electrochromic performance, but its photoelectric effect has not mentioned in the literature. The electrochromic properties of Lu(TBPc){sub 2} have been measured by cyclic voltammetry (CV) and UV-Vis spectrometer at the same time. It takes less than 1.5 s for the color to change from red to green under 0.9 V. Its cycle life is at least over 500 times. Furthermore, we also investigate its photoelectric conversion properties. Its photoelectric cell exhibits a positive photo-electricity conversion effect with a short-circuit photocurrent (46.4 {mu}A/cm{sup 2}) under illumination of white light (1.201 mW/cm{sup 2})

  19. Vacuum ultraviolet field emission lamp consisting of neodymium ion doped lutetium fluoride thin film as phosphor.

    PubMed

    Yanagihara, Masahiro; Tsuji, Takayuki; Yusop, Mohd Zamri; Tanemura, Masaki; Ono, Shingo; Nagami, Tomohito; Fukuda, Kentaro; Suyama, Toshihisa; Yokota, Yuui; Yanagida, Takayuki; Yoshikawa, Akira

    2014-01-01

    A vacuum ultraviolet (VUV) field emission lamp was developed by using a neodymium ion doped lutetium fluoride (Nd(3+) : LuF3) thin film as solid-state phosphor and carbon nanofiber field electron emitters. The thin film was synthesized by pulsed laser deposition and incorporated into the lamp. The cathodoluminescence spectra of the lamp showed multiple emission peaks at 180, 225, and 255 nm. These emission spectra were in good agreement with the spectra reported for the Nd(3+) : LuF3 crystal. Moreover, application of an acceleration voltage effectively increased the emission intensity. These results contribute to the performance enhancement of the lamp operating in the VUV region.

  20. Photoemission spectroscopy study of the lanthanum lutetium oxide/silicon interface

    SciTech Connect

    Nichau, A.; Schnee, M.; Schubert, J.; Bernardy, P.; Hollaender, B.; Buca, D.; Mantl, S.; Besmehn, A.; Breuer, U.; Rubio-Zuazo, J.; Castro, G. R.; Muecklich, A.; Borany, J. von

    2013-04-21

    Rare earth oxides are promising candidates for future integration into nano-electronics. A key property of these oxides is their ability to form silicates in order to replace the interfacial layer in Si-based complementary metal-oxide field effect transistors. In this work a detailed study of lanthanum lutetium oxide based gate stacks is presented. Special attention is given to the silicate formation at temperatures typical for CMOS processing. The experimental analysis is based on hard x-ray photoemission spectroscopy complemented by standard laboratory experiments as Rutherford backscattering spectrometry and high-resolution transmission electron microscopy. Homogenously distributed La silicate and Lu silicate at the Si interface are proven to form already during gate oxide deposition. During the thermal treatment Si atoms diffuse through the oxide layer towards the TiN metal gate. This mechanism is identified to be promoted via Lu-O bonds, whereby the diffusion of La was found to be less important.

  1. Vacuum Ultraviolet Field Emission Lamp Consisting of Neodymium Ion Doped Lutetium Fluoride Thin Film as Phosphor

    PubMed Central

    Yanagihara, Masahiro; Tsuji, Takayuki; Yusop, Mohd Zamri; Tanemura, Masaki; Nagami, Tomohito; Fukuda, Kentaro; Suyama, Toshihisa; Yokota, Yuui; Yanagida, Takayuki; Yoshikawa, Akira

    2014-01-01

    A vacuum ultraviolet (VUV) field emission lamp was developed by using a neodymium ion doped lutetium fluoride (Nd3+ : LuF3) thin film as solid-state phosphor and carbon nanofiber field electron emitters. The thin film was synthesized by pulsed laser deposition and incorporated into the lamp. The cathodoluminescence spectra of the lamp showed multiple emission peaks at 180, 225, and 255 nm. These emission spectra were in good agreement with the spectra reported for the Nd3+ : LuF3 crystal. Moreover, application of an acceleration voltage effectively increased the emission intensity. These results contribute to the performance enhancement of the lamp operating in the VUV region. PMID:25302320

  2. Half-life measurements of lutetium-176 using underground HPGe-detectors.

    PubMed

    Hult, Mikael; Vidmar, Tim; Rosengård, Ulf; Marissens, Gerd; Lutter, Guillaume; Sahin, Namik

    2014-05-01

    The half-life of (176)Lu was determined by measuring the (176)Lu activity in metallic lutetium foils. Three different HPGe-detectors located 225 m underground were employed for the study. Measurements using the sum-peak method were performed and resulted in an average massic activity of (52.61±0.36) Bq g(-1). The foils were of natural isotopic abundance so using the massic activity and the value of the natural isotopic abundance of (2.59±0.01)%, a half-life of (3.722±0.029)×10(10)a could be calculated. © 2013 Elsevier Ltd. All rights reserved.

  3. Formulation and characterization of lutetium-177-labeled stannous (tin) colloid for radiosynovectomy.

    PubMed

    Arora, Geetanjali; Singh, Manoranjan; Jha, Pragati; Tripathy, Sarthak; Bal, Chandrasekhar; Mukherjee, Anirban; Shamim, Shamim A

    2017-07-01

    Easy large-scale production, easy availability, cost-effectiveness, long half-life, and favorable radiation characteristics have made lutetium-177 (Lu) a preferred radionuclide for use in therapy. Lutetium-177-labeled stannous (Lu-Sn) colloid particles were formulated for application in radiosynovectomy, followed by in-vitro and in-vivo characterization. Stannous chloride (SnCl2) solution and Lu were heated together, the pH was adjusted, and the particles were recovered by centrifugation. The heating time and amount of SnCl2 were varied to optimize the labeling protocol. The labeling efficiency (LE) and radiochemical purity (RCP) of the product were determined. The size and shape of the particles were determined by means of electron microscopy. In-vitro stability was tested in PBS and synovial fluid, and in-vivo stability was tested in humans. LE and RCP were greater than 95% and ∼99% (Rf=0-0.1), respectively. Aggregated colloidal particles were spherical (mean size: 241±47 nm). The product was stable in vitro for up to 7 days in PBS as well as in synovial fluid. Injection of the product into the infected knee joint of a patient resulted in its homogenous distribution in the intra-articular space, as seen on the scan. No leakage of activity was seen outside the knee joint even 7 days after injection, indicating good tracer binding and in-vivo stability. Lu-Sn colloid was successfully prepared with a high LE (>95%) and high RCP (99%) under optimized reaction conditions. Because of the numerous benefits of Lu and the ease of preparation of tin colloid particles, Lu-Sn colloid particles are significantly superior to its currently available counterparts for use in radiosynovectomy.

  4. 32 CFR 156.1 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... PROGRAM (DoDPSP) § 156.1 Purpose. This part: (a) Updates the policy and responsibilities for the DoDPSP under Pub. L. 81-832; E.O. 10450, 18 FR 2489, 3 CFR, 1949-1953 Comp., p. 936; E.O. 10865, 25 FR 1583, 3 CFR, 1959-1963 Comp., p. 398; E.O. 12333, 46 FR 59941, 3 CFR, 1981 Comp., p.200; and E.O. 12356, 47 FR...

  5. A new coprecipitation methodology with lutetium hydroxide for preconcentration of heavy metal ions in herbal plant samples.

    PubMed

    Soylak, Mustafa; Murat, Ipek

    2014-01-01

    A new coprecipitation methodology that used lutetium hydroxide as a precipitant for Cu(II), Pb(II), Mn(II), Co(II), Cd(II), Fe(III), and Ni(II) ions in herbal plant and water samples for analysis by atomic absorption spectrometry has been investigated. The parameters such as pH, amount of lutetium, and volume of aqueous sample were optimized for the recovery of these seven metals. The effects of concomitant ions on the separation-preconcentration of analytes were also checked. The validation of the procedure was checked with addition recovery tests and analysis of Standard Reference Material 1570a-Trace Elements in Spinach Leaves and TMDA-70 fortified lake water Certified Reference Material. The LODs for analyte ions were in the range of 1.7-7.2 microg/L. The application of the present procedure was successfully performed for the analysis of analyte contents of herbal plant samples from Turkey.

  6. Rare-earth antisites in lutetium aluminum garnets: Influence on lattice parameter and Ce3+ multicenter structure

    NASA Astrophysics Data System (ADS)

    Przybylińska, H.; Wittlin, A.; Ma, Chong-Geng; Brik, M. G.; Kamińska, A.; Sybilski, P.; Zorenko, Yu.; Nikl, M.; Gorbenko, V.; Fedorov, A.; Kučera, M.; Suchocki, A.

    2014-07-01

    Low temperature, infrared transmission spectra of lutetium aluminum garnet (LuAG) bulk crystals and epitaxial layers doped with Ce are presented. In the region of intra-configurational 4f-4f transitions the spectra of the bulk LuAG crystal exhibit the signatures of several different Ce3+ related centers. Apart from the dominant center, associated with Ce substituting lutetium, at least six other centers are found, some of them attributed to so-called antisite locations of rare-earth ions in the garnet host, i.e., ions in the Al positions. X-ray diffraction data prove lattice expansion of bulk LuAG crystals due presence of rare-earth antisites.

  7. Features of the spectral dependences of transmittance of organic semiconductors based on tert-butyl substituted lutetium phthalocyanine molecules

    SciTech Connect

    Belogorokhov, I. A.; Tikhonov, E. V.; Dronov, M. A.; Belogorokhova, L. I.; Ryabchikov, Yu. V.; Tomilova, L. G.; Khokhlov, D. R.

    2011-11-15

    Vibronic properties of organic semiconductors based on tert-butyl substituted phthalocyanine lutetium diphthalocyanine molecules are studied by IR and Raman spectroscopy. It is shown that substitution of several carbon atoms in initial phthalocyanine (Pc) ligands with {sup 13}C isotope atoms causes a spectral shift in the main absorption lines attributed to benzene, isoindol, and peripheral C-H groups. A comparison of spectral characteristics showed that the shift can vary from 3 to 1 cm{sup -1}.

  8. A Study of the Physical and Mechanical Properties of Lutetium Compared with Those of Transition Metals: A Data Mining Approach

    NASA Astrophysics Data System (ADS)

    Settouti, Nadera; Aourag, Hafid

    2015-01-01

    In this article, we study the physical and mechanical properties of lutetium, which will be compared with the elements of the third-row transition metals (Cs, Ba, Hf, Ta, W, Re, Os, Ir, Pt, Au, Tl, Pb, and Bi). Data mining is an ideal approach for analyzing the information and exploring the hidden knowledge among the data. The purpose of the data mining scheme is to identify and classify the effects of the relationships existing between properties. The results of the investigation are presented by means of multivariate modeling methods, such as the principal component analysis and the partial least squares regression to discover the implicit, yet meaningful, relationship between the elements of the data set, and to locate correlations between the properties of the materials. In this study, we present a data mining approach to discover such unusual correlations between properties of the elements. When comparing the properties of the transition metals with those of lutetium, our results show that lutetium shares many properties and similarities with the transition metals of the sixth row in the periodic table and can be well described as a transition metal.

  9. 26 CFR 1.56A-5 - Tax carryovers.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 1 2014-04-01 2013-04-01 true Tax carryovers. 1.56A-5 Section 1.56A-5 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY INCOME TAX INCOME TAXES Regulations Applicable to Taxable Years Beginning in 1969 and Ending in 1970 § 1.56A-5 Tax carryovers. (a) In...

  10. 26 CFR 1.56A-5 - Tax carryovers.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 1 2012-04-01 2012-04-01 false Tax carryovers. 1.56A-5 Section 1.56A-5 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY INCOME TAX INCOME TAXES Regulations Applicable to Taxable Years Beginning in 1969 and Ending in 1970 § 1.56A-5 Tax carryovers. (a) In...

  11. 26 CFR 1.56A-5 - Tax carryovers.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 1 2010-04-01 2010-04-01 true Tax carryovers. 1.56A-5 Section 1.56A-5 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY INCOME TAX INCOME TAXES Regulations Applicable to Taxable Years Beginning in 1969 and Ending in 1970 § 1.56A-5 Tax carryovers. (a) In...

  12. 26 CFR 1.56A-5 - Tax carryovers.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 1 2013-04-01 2013-04-01 false Tax carryovers. 1.56A-5 Section 1.56A-5 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY INCOME TAX INCOME TAXES Regulations Applicable to Taxable Years Beginning in 1969 and Ending in 1970 § 1.56A-5 Tax carryovers. (a) In...

  13. 18 CFR 156.9 - Protests and interventions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... interventions. 156.9 Section 156.9 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY...) OF THE NATURAL GAS ACT § 156.9 Protests and interventions. Notices of applications, as provided by... interested regulatory agency desiring to intervene may file its notice of intervention. Failure to make...

  14. 45 CFR 156.515 - CO-OP standards.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 1 2014-10-01 2014-10-01 false CO-OP standards. 156.515 Section 156.515 Public... Operated and Oriented Plan Program § 156.515 CO-OP standards. (a) General. A CO-OP must satisfy the...) Governance requirements. A CO-OP must meet the following governance requirements: (1) Member control. A...

  15. 45 CFR 156.515 - CO-OP standards.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 1 2012-10-01 2012-10-01 false CO-OP standards. 156.515 Section 156.515 Public... Operated and Oriented Plan Program § 156.515 CO-OP standards. (a) General. A CO-OP must satisfy the...) Governance requirements. A CO-OP must meet the following governance requirements: (1) Member control. A...

  16. 45 CFR 156.515 - CO-OP standards.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 1 2013-10-01 2013-10-01 false CO-OP standards. 156.515 Section 156.515 Public... Operated and Oriented Plan Program § 156.515 CO-OP standards. (a) General. A CO-OP must satisfy the...) Governance requirements. A CO-OP must meet the following governance requirements: (1) Member control. A...

  17. 26 CFR 156.7701-1 - Tax return preparer.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 17 2010-04-01 2010-04-01 false Tax return preparer. 156.7701-1 Section 156... EXCISE TAXES (CONTINUED) EXCISE TAX ON GREENMAIL Procedure and Administration § 156.7701-1 Tax return preparer. (a) In general. For the definition of a tax return preparer, see § 301.7701-15 of this chapter...

  18. 26 CFR 1.56A-5 - Tax carryovers.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 1 2011-04-01 2009-04-01 true Tax carryovers. 1.56A-5 Section 1.56A-5 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY INCOME TAX INCOME TAXES Regulations Applicable to Taxable Years Beginning in 1969 and Ending in 1970 § 1.56A-5 Tax carryovers. (a) In general...

  19. 45 CFR 156.230 - Network adequacy standards.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 1 2013-10-01 2013-10-01 false Network adequacy standards. 156.230 Section 156... Qualified Health Plan Minimum Certification Standards § 156.230 Network adequacy standards. (a) General requirement. A QHP issuer must ensure that the provider network of each of its QHPs, as available to all...

  20. 45 CFR 156.230 - Network adequacy standards.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 1 2014-10-01 2014-10-01 false Network adequacy standards. 156.230 Section 156... Qualified Health Plan Minimum Certification Standards § 156.230 Network adequacy standards. (a) General requirement. A QHP issuer must ensure that the provider network of each of its QHPs, as available to all...

  1. 38 CFR 17.156 - Eligibility for automobile adaptive equipment.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... automobile adaptive equipment. 17.156 Section 17.156 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS MEDICAL Automotive Equipment and Driver Training § 17.156 Eligibility for automobile adaptive equipment. Automobile adaptive equipment may be authorized if the Under Secretary for Health...

  2. 38 CFR 17.156 - Eligibility for automobile adaptive equipment.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... automobile adaptive equipment. 17.156 Section 17.156 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS MEDICAL Automotive Equipment and Driver Training § 17.156 Eligibility for automobile adaptive equipment. Automobile adaptive equipment may be authorized if the Under Secretary for Health...

  3. 38 CFR 17.156 - Eligibility for automobile adaptive equipment.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... automobile adaptive equipment. 17.156 Section 17.156 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS MEDICAL Automotive Equipment and Driver Training § 17.156 Eligibility for automobile adaptive equipment. Automobile adaptive equipment may be authorized if the Under Secretary for Health...

  4. 45 CFR 156.911 - Dismissal of request for hearing.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 1 2014-10-01 2014-10-01 false Dismissal of request for hearing. 156.911 Section 156.911 Public Welfare Department of Health and Human Services REQUIREMENTS RELATING TO HEALTH CARE... EXCHANGES Administrative Review of QHP Issuer Sanctions in Federally-Facilitated Exchanges § 156.911...

  5. 10 CFR 52.156 - Contents of applications; general information.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Contents of applications; general information. 52.156 Section 52.156 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS Manufacturing Licenses § 52.156 Contents of applications; general...

  6. 19 CFR 191.156 - Bill of lading.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... produce the bill of lading and such evidence of exportation and of his right to make the drawback entry as... 19 Customs Duties 2 2010-04-01 2010-04-01 false Bill of lading. 191.156 Section 191.156 Customs... (CONTINUED) DRAWBACK Merchandise Exported From Continuous Customs Custody § 191.156 Bill of lading. (a...

  7. 17 CFR 156.2 - Registration of broker association.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... association. 156.2 Section 156.2 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION BROKER ASSOCIATIONS § 156.2 Registration of broker association. (a) Registration required. It shall be unlawful for any member of a broker association to receive or to execute an order unless the broker...

  8. 17 CFR 156.4 - Disclosure of Broker Association Membership.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Association Membership. 156.4 Section 156.4 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION BROKER ASSOCIATIONS § 156.4 Disclosure of Broker Association Membership. Each contract market... associations which identifies for each such association the name of each person who is a member or otherwise...

  9. 32 CFR 156.5 - National security positions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 1 2014-07-01 2014-07-01 false National security positions. 156.5 Section 156.5 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE SECURITY DEPARTMENT OF DEFENSE PERSONNEL SECURITY PROGRAM (PSP) § 156.5 National security positions. (a) Procedures. The objective of...

  10. 40 CFR 156.208 - Restricted-entry statements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Section 156.208 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS LABELING REQUIREMENTS FOR PESTICIDES AND DEVICES Worker Protection Statements § 156.208 Restricted-entry... ingredient to the criteria of § 156.62. The most toxic of the applicable toxicity categories that...

  11. 37 CFR 41.156 - Compelling testimony and production.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... production. 41.156 Section 41.156 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK... Cases § 41.156 Compelling testimony and production. (a) Authorization required. A party seeking to compel testimony or production of documents or things must file a miscellaneous motion for...

  12. 45 CFR 156.122 - Prescription drug benefits.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 1 2014-10-01 2014-10-01 false Prescription drug benefits. 156.122 Section 156... Essential Health Benefits Package § 156.122 Prescription drug benefits. (a) A health plan does not provide... at least the greater of: (i) One drug in every United States Pharmacopeia (USP) category and...

  13. 45 CFR 156.122 - Prescription drug benefits.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 1 2013-10-01 2013-10-01 false Prescription drug benefits. 156.122 Section 156... Essential Health Benefits Package § 156.122 Prescription drug benefits. (a) A health plan does not provide... at least the greater of: (i) One drug in every United States Pharmacopeia (USP) category and...

  14. 7 CFR 4279.156 - Planning and performing development.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Planning and performing development. 4279.156 Section 4279.156 Agriculture Regulations of the Department of Agriculture (Continued) RURAL BUSINESS... Industry Loans § 4279.156 Planning and performing development. (a) Design policy. The lender must...

  15. 42 CFR 483.156 - Registry of nurse aides.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Registry of nurse aides. 483.156 Section 483.156... That Must Be Met by States and State Agencies: Nurse Aide Training and Competency Evaluation, and Paid Feeding Assistants § 483.156 Registry of nurse aides. (a) Establishment of registry. The State...

  16. 40 CFR 156.144 - Residue removal instructions-general.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...) PESTICIDE PROGRAMS LABELING REQUIREMENTS FOR PESTICIDES AND DEVICES Container Labeling § 156.144 Residue... section, the label of each pesticide product must include the applicable instructions for removing pesticide residues from the container prior to container disposal that are specified in § 156.146 and § 156...

  17. 40 CFR 156.144 - Residue removal instructions-general.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...) PESTICIDE PROGRAMS LABELING REQUIREMENTS FOR PESTICIDES AND DEVICES Container Labeling § 156.144 Residue... section, the label of each pesticide product must include the applicable instructions for removing pesticide residues from the container prior to container disposal that are specified in § 156.146 and § 156...

  18. 40 CFR 156.144 - Residue removal instructions-general.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) PESTICIDE PROGRAMS LABELING REQUIREMENTS FOR PESTICIDES AND DEVICES Container Labeling § 156.144 Residue... section, the label of each pesticide product must include the applicable instructions for removing pesticide residues from the container prior to container disposal that are specified in § 156.146 and § 156...

  19. 40 CFR 156.144 - Residue removal instructions-general.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...) PESTICIDE PROGRAMS LABELING REQUIREMENTS FOR PESTICIDES AND DEVICES Container Labeling § 156.144 Residue... section, the label of each pesticide product must include the applicable instructions for removing pesticide residues from the container prior to container disposal that are specified in § 156.146 and § 156...

  20. 40 CFR 156.144 - Residue removal instructions-general.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...) PESTICIDE PROGRAMS LABELING REQUIREMENTS FOR PESTICIDES AND DEVICES Container Labeling § 156.144 Residue... section, the label of each pesticide product must include the applicable instructions for removing pesticide residues from the container prior to container disposal that are specified in § 156.146 and § 156...

  1. 37 CFR 41.156 - Compelling testimony and production.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... production. 41.156 Section 41.156 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK... Cases § 41.156 Compelling testimony and production. (a) Authorization required. A party seeking to compel testimony or production of documents or things must file a miscellaneous motion for authorization...

  2. 24 CFR 17.156 - Stay of offset.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Stay of offset. 17.156 Section 17.156 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development... Payment Offset Provisions and Administrative Wage Garnishment § 17.156 Stay of offset. If the...

  3. 17 CFR 1.56 - Prohibition of guarantees against loss.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Prohibition of guarantees against loss. 1.56 Section 1.56 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION GENERAL REGULATIONS UNDER THE COMMODITY EXCHANGE ACT Miscellaneous § 1.56 Prohibition of guarantees...

  4. 30 CFR 206.156 - Transportation allowances-general.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Transportation allowances-general. 206.156 Section 206.156 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT PRODUCT VALUATION Federal Gas § 206.156 Transportation allowances—general. (a) Where the value of...

  5. 10 CFR 52.156 - Contents of applications; general information.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Contents of applications; general information. 52.156 Section 52.156 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS Manufacturing Licenses § 52.156 Contents of applications; general information...

  6. 10 CFR 52.156 - Contents of applications; general information.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Contents of applications; general information. 52.156 Section 52.156 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS Manufacturing Licenses § 52.156 Contents of applications; general information...

  7. 10 CFR 52.156 - Contents of applications; general information.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Contents of applications; general information. 52.156 Section 52.156 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS Manufacturing Licenses § 52.156 Contents of applications; general information...

  8. 10 CFR 52.156 - Contents of applications; general information.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Contents of applications; general information. 52.156 Section 52.156 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS Manufacturing Licenses § 52.156 Contents of applications; general information...

  9. 7 CFR 4279.156 - Planning and performing development.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 15 2013-01-01 2013-01-01 false Planning and performing development. 4279.156 Section 4279.156 Agriculture Regulations of the Department of Agriculture (Continued) RURAL BUSINESS... Industry Loans § 4279.156 Planning and performing development. (a) Design policy. The lender must ensure...

  10. 33 CFR 156.215 - Pre-arrival notices.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Pre-arrival notices. 156.215 Section 156.215 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED... Hazardous Material Cargoes § 156.215 Pre-arrival notices. (a) The master, owner or agent of each vessel...

  11. 33 CFR 156.215 - Pre-arrival notices.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Pre-arrival notices. 156.215 Section 156.215 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED... Hazardous Material Cargoes § 156.215 Pre-arrival notices. (a) The master, owner or agent of each vessel...

  12. 33 CFR 156.215 - Pre-arrival notices.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Pre-arrival notices. 156.215 Section 156.215 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED... Hazardous Material Cargoes § 156.215 Pre-arrival notices. (a) The master, owner or agent of each vessel...

  13. 40 CFR 98.156 - Data reporting requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Data reporting requirements. 98.156 Section 98.156 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING HCFC-22 Production and HFC-23 Destruction § 98.156...

  14. 40 CFR 98.156 - Data reporting requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 22 2012-07-01 2012-07-01 false Data reporting requirements. 98.156 Section 98.156 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING HCFC-22 Production and HFC-23 Destruction § 98.156...

  15. 40 CFR 86.156-98 - Calculations; refueling test.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 18 2010-07-01 2010-07-01 false Calculations; refueling test. 86.156-98 Section 86.156-98 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... Complete Heavy-Duty Vehicles; Test Procedures § 86.156-98 Calculations; refueling test. (a) The...

  16. 33 CFR 156.300 - Designated lightering zones.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Designated lightering zones. 156.300 Section 156.300 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY... Requirements for the Gulf of Mexico § 156.300 Designated lightering zones. The following lightering zones...

  17. 33 CFR 156.300 - Designated lightering zones.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Designated lightering zones. 156.300 Section 156.300 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY... Requirements for the Gulf of Mexico § 156.300 Designated lightering zones. The following lightering zones...

  18. 33 CFR 156.300 - Designated lightering zones.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Designated lightering zones. 156.300 Section 156.300 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY... Requirements for the Gulf of Mexico § 156.300 Designated lightering zones. The following lightering zones...

  19. 42 CFR 483.156 - Registry of nurse aides.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 5 2011-10-01 2011-10-01 false Registry of nurse aides. 483.156 Section 483.156... That Must Be Met by States and State Agencies: Nurse Aide Training and Competency Evaluation, and Paid Feeding Assistants § 483.156 Registry of nurse aides. (a) Establishment of registry. The State must...

  20. Photodynamic therapy with motexafin lutetium for rectal cancer: a preclinical model in the dog.

    PubMed

    Ross, H M; Smelstoys, J A; Davis, G J; Kapatkin, A S; Del Piero, F; Reineke, E; Wang, H; Zhu, T C; Busch, T M; Yodh, A G; Hahn, S M

    2006-10-01

    Local recurrence of rectal cancer remains a significant clinical problem despite multi-modality therapy. Photodynamic Therapy (PDT) is a cancer treatment which generates tumor kill through the production of singlet oxygen in cells containing a photosensitizing drug when exposed to laser light of a specific wavelength. PDT is a promising modality for prevention of local recurrence of rectal cancer for several reasons: tumor cells may selectively retain photosensitizer at higher levels than normal tissues, the pelvis after mesorectal excision is a fixed space amenable to intra-operative illumination, and PDT can generate toxicity in tissues up to 1 cm thick. This study evaluated the safety, tissue penetration of 730 nm light, normal tissue toxicity and surgical outcome in a dog model of rectal resection after motexafin lutetium-mediated photodynamic therapy. Ten mixed breed dogs were used. Eight dogs underwent proctectomy and low rectal end to end stapled anastomosis. Six dogs received the photosensitizing agent motexafin lutetium (MLu, Pharmacyclics, Inc., Sunnyvale, CA) of 2 mg/kg preoperatively and underwent subsequent pelvic illumination of the transected distal rectum of 730 nm light with light doses ranging from 0.5 J/cm(2) to 10 J/cm(2) three hours after drug delivery. Two dogs received light, but no drug, and underwent proctectomy and low-rectal stapled anastomosis. Two dogs underwent midline laparotomy and pelvic illumination. Light penetration in tissues was determined for small bowel, rectum, pelvic sidewall, and skin. Clinical outcomes were recorded. Animals were sacrificed at 14 days and histological evaluation was performed. All dogs recovered uneventfully. No dog suffered an anastomotic leak. Severe tissue toxicity was not seen. Histological findings at necropsy revealed mild enteritis in all dogs. The excitation light penetration depths were 0.46 +/- 0.18, 0.46 +/- 0.15, and 0.69 +/- 0.39 cm, respectively, for rectum, small bowel, and peritoneum in

  1. Arabidopsis mutant sk156 reveals complex regulation of SPL15 in a miR156-controlled gene network

    PubMed Central

    2012-01-01

    Background The Arabidopsis microRNA156 (miR156) regulates 11 members of the SQUAMOSA PROMOTER BINDING PROTEIN LIKE (SPL) family by base pairing to complementary target mRNAs. Each SPL gene further regulates a set of other genes; thus, miR156 controls numerous genes through a complex gene regulation network. Increased axillary branching occurs in transgenic Arabidopsis overexpressing miR156b, similar to that observed in loss-of-function max3 and max4 mutants with lesions in carotenoid cleavage dioxygenases. Arabidopsis miR156b was found to enhance carotenoid levels and reproductive shoot branching when expressed in Brassica napus, suggesting a link between miR156b expression and carotenoid metabolism. However, details of the miR156 regulatory network of SPL genes related to carotenoid metabolism are not known. Results In this study, an Arabidopsis T-DNA enhancer mutant, sk156, was identified due to its altered branching and trichome morphology and increased seed carotenoid levels compared to wild type (WT) ecovar Columbia. Enhanced miR156b expression due to the 35S enhancers present on the T-DNA insert was responsible for these phenotypes. Constitutive and leaf primodium-specific expression of a miR156-insensitive (mutated) SPL15 (SPL15m) largely restored WT seed carotenoid levels and plant morphology when expressed in sk156. The Arabidopsis native miR156-sensitive SPL15 (SPL15n) and SPL15m driven by a native SPL15 promoter did not restore the WT phenotype in sk156. Our findings suggest that SPL15 function is somewhat redundant with other SPL family members, which collectively affect plant phenotypes. Moreover, substantially decreased miR156b transcript levels in sk156 expressing SPL15m, together with the presence of multiple repeats of SPL-binding GTAC core sequence close to the miR156b transcription start site, suggested feedback regulation of miR156b expression by SPL15. This was supported by the demonstration of specific in vitro interaction between DNA

  2. The melting behavior of lutetium aluminum perovskite LuAlO3

    NASA Astrophysics Data System (ADS)

    Klimm, Detlef

    2010-02-01

    DTA measurements with mixtures of aluminum oxide and lutetium oxide around the 1:1 perovskite composition were performed up to 1970C. A peak with onset 1901C was due to the melting of the eutectic Lu4Al2O9 (monoclinic phase) and LuAlO3 (perovskite). Neither peritectic melting of the perovskite nor its decomposition in the solid phase could be resolved experimentally. The maximum of the eutectic peak size is near x=0.44, on the Lu-rich side of the perovskite, which is consistent with the conclusion that LuAlO3 melts peritectically at ca. 1907C as proposed by Wu, Pelton, J. Alloys Compd. 179 (1992) 259. Thermodynamic equilibrium calculation reveals that under strongly reducing conditions (oxygen partial pressure <10-13 bar) aluminum(III) oxide can be reduced to suboxides or even Al metal. It is shown that under such conditions a new phase field with liquid Al can appear.

  3. Physical properties of zircon and scheelite lutetium orthovanadate: Experiment and first-principles calculation

    SciTech Connect

    Huang, Zuocai; Zhang, Lei; Pan, Wei

    2013-09-15

    Pure zircon and scheelite LuVO{sub 4} were prepared by solid state reaction and high-pressure route, respectively. Structure, elastic constants, lattice dynamics and thermodynamics of LuVO{sub 4} polymorphs were studied by experiments and first principles calculation. Calculations here are in good agreement with the experimental results. The phonon dispersions of LuVO{sub 4} polymorphs were studied by the linear response method. The calculated phonon dispersions show that zircon and scheelite LuVO{sub 4} phases are dynamically stable. Raman-active frequencies were measured and assigned to different modes according to the calculations. The internal frequencies shift downward after phase transition from zircon to scheelite. Born effective charge tensors elements for both phases are analyzed. The finite temperature thermodynamic properties of LuVO{sub 4} polymorphs were calculated from the obtained phonon density of states by quasi-harmonic approach. - Graphical abstract: Lutetium orthovanadate polymorphs were synthesized by SSR and HP methods and their physical and chemical properties, including lattice dynamical properties, were determined by DFT calculations and experiments. Display Omitted - Highlights: • Pure zircon and scheelite LuVO{sub 4} polymorphs were synthesized by solid state reaction and high-pressure route. • Chemical and physical properties of LuVO4 polymorphs were studied by experiments and first principles calculation. • Raman-active frequencies were measured and assigned to different modes according to the calculations. • Lattice dynamics of polymorphs were discussed in details.

  4. Lutetium 177-DOTA-TATE therapy for esthesioneuroblastoma: A case report

    PubMed Central

    Sabongi, Juliano Guerra; Gonçalves, Mônica Carboni Pereira; Alves, Cira Danielle Casado; Alves, João; Scapulatempo-Neto, Cristovam; Moriguchi, Sonia Marta

    2016-01-01

    Esthesioneuroblastoma (ENB), also known as olfactory neuroblastoma, is a rare malignant tumor that accounts for 3% of all tumors of the nasal cavity. The incidence of ENB is 0.4 cases per million in the general population, and the most common symptoms are nasal obstruction and epistaxis. Previous studies have indicated the presence of somatostatin receptors in this tumor type. Common treatment strategies for ENB include resection and adjuvant radiotherapy and/or chemotherapy (combined treatment); however, the rate of recurrence is high. Treatment of neuroendocrine tumors using radionuclides bound to somatostatin analogues is well established in clinical practice. However, a standard and effective therapeutic approach has not been reported for ENB. The current study described the case of a 74-year-old female with numerous recurrences of ENB following multiple treatments and without possibility of resection. The patient was treated with the radiolabeled-somatostatin analogue, 177Lutetium-DOTA-octreotate (177Lu-DOTA-TATE), which successfully controlled the disease. This suggests that 177Lu-DOTA-TATE is a potential treatment for ENB and may represent an effective alternative and novel therapeutic strategy for this disease. PMID:27882120

  5. Even-parity Rydberg and autoionizing states of lutetium by laser resonance-ionization spectroscopy

    NASA Astrophysics Data System (ADS)

    Li, R.; Lassen, J.; Zhong, Z. P.; Jia, F. D.; Mostamand, M.; Li, X. K.; Reich, B. B.; Teigelhöfer, A.; Yan, H.

    2017-05-01

    Multistep laser resonance ionization spectroscopy of lutetium (Lu) has been performed at TRIUMF's off-line laser ion source test stand. The even-parity Rydberg series 6 s2n d 2D3 /2 , 6 s2n d 2D5 /2 , and 6 s2n s 2S1 /2 were observed converging to the 6 s2 ionization potential. The experimental results have been compared to those of previous work. Fifty-one levels of Rydberg series 6 s2n d 2D5 /2 and 52 levels of Rydberg series 6 s2n s 2S1 /2 were reported. Additionally, six even-parity autoionization (AI) series converging to Lu ionic states 5 d 6 s 3D1 and 5 d 6 s 3D2 were observed. The level energies of these AI states were measured. The configurations of the AI states were assigned by relativistic multichannel theory within the framework of multichannel quantum defect theory.

  6. Lutetium speciation and toxicity in a microbial bioassay: testing the free-ion model for lanthanides.

    PubMed

    Weltje, Lennart; Verhoof, Lars R C W; Verweij, Wilko; Hamers, Timo

    2004-12-15

    The validity of the free-ion model (FIM) for the element lutetium (Lu), a member of the lanthanides, was assessed in experiments with the bacterium Vibrio fischeri. The FIM is mainly based on divalent metals and synthetic ligands and has not yet been validated for the trivalent lanthanides. The bioluminescence response of V. fischeri was studied at different Lu concentrations in the presence and absence of natural and synthetic organic ligands [citrate, malate, oxalate, acetate, ethylenediaminetetraacetate (EDTA), and nitrilotriacetate (NTA)]. All ligands were tested separately to ensure that their concentrations would not cause adverse effects themselves. Free Lu3+ concentrations were calculated with a speciation program, after extension of its database with the relevant Lu equilibria. The results confirmed the FIM for Lu: that is, in contrast to total dissolved Lu concentrations, free Lu3+ concentrations had an apparent relationship with the response of V. fischeri. However, a contribution of minor inorganic Lu complexes cannot be ruled out. In the presence of malate and oxalate, the EC50 for Lu3+ decreased faster in time than for the other ligands, indicating lower elimination rates. With an EC50 of 1.57 microM, Lu3+ is more toxic than La3+, Cd2+, or Zn2+ and approximately equally as toxic as Cu2+. Although the pH increased slightly during the experiments, it was shown that the influence of pH on Lu speciation was limited.

  7. Lutetium 177-DOTA-TATE therapy for esthesioneuroblastoma: A case report.

    PubMed

    Sabongi, Juliano Guerra; Gonçalves, Mônica Carboni Pereira; Alves, Cira Danielle Casado; Alves, João; Scapulatempo-Neto, Cristovam; Moriguchi, Sonia Marta

    2016-11-01

    Esthesioneuroblastoma (ENB), also known as olfactory neuroblastoma, is a rare malignant tumor that accounts for 3% of all tumors of the nasal cavity. The incidence of ENB is 0.4 cases per million in the general population, and the most common symptoms are nasal obstruction and epistaxis. Previous studies have indicated the presence of somatostatin receptors in this tumor type. Common treatment strategies for ENB include resection and adjuvant radiotherapy and/or chemotherapy (combined treatment); however, the rate of recurrence is high. Treatment of neuroendocrine tumors using radionuclides bound to somatostatin analogues is well established in clinical practice. However, a standard and effective therapeutic approach has not been reported for ENB. The current study described the case of a 74-year-old female with numerous recurrences of ENB following multiple treatments and without possibility of resection. The patient was treated with the radiolabeled-somatostatin analogue, (177)Lutetium-DOTA-octreotate ((177)Lu-DOTA-TATE), which successfully controlled the disease. This suggests that (177)Lu-DOTA-TATE is a potential treatment for ENB and may represent an effective alternative and novel therapeutic strategy for this disease.

  8. Volatile organic compounds sensing properties of tetrakis(alkylthio)-substituted lutetium(III) bisphthalocyanines thin films.

    PubMed

    Kilinç, Necmettin; Atilla, Devrim; Gürek, Ayşe Gül; Oztürk, Zafer Ziya; Ahsen, Vefa

    2009-11-15

    The effect of volatile organic compounds (VOCs) such as acetone, methanol, ethanol, chloroform, carbon tetrachloride, dichloromethane, and hexane on electrical conductivity of thin films of bis[tetrakis(alkylthio)phthalocyaninato]lutetium(III) double decker complexes [(C(n)H(2n+1)S)(4)Pc](2)Lu(III) was investigated. The [(C(n)H(2n+1)S)(4)Pc](2)Lu(III) molecules substituted with different alkylthia chains (n=6, 8, 10, 12, and 16) were coated on interdigital transducers using a jet spray technique. A change (increase or decrease) in the conductivity of the [(C(n)H(2n+1)S)(4)Pc](2)Lu(III) films was observed depending on the concentration of the VOCs, which was ranging from 500 to 5000 ppm. The decrease in the conductivity of the sensors for the dissolvent of the compounds (chloroform, carbon tetrachloride, dichloromethane and hexane) could be related to swelling of the films. On the other hand, the increase in the conductivity of the sensors for the other VOCs (acetone, methanol and ethanol) could be resulted from that the VOCs act as electron donors and/or acceptors in the films. A linear relationship between the sensor response and concentration of the VOC vapors is obtained. The sensitivities of the [(C(n)H(2n+1)S)(4)Pc](2)Lu(III) films were in the range of 2.10(-4)-3.10(-3)%/ppm.

  9. 46 CFR 160.156-5 - Incorporation by reference.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... inspection at Coast Guard Headquarters. Contact Commandant (CG-ENG-4), Attn: Lifesaving and Fire Safety... Shapes, (approved October 1, 2008), IBR approved for § 160.156-7 (“ASTM A 276”). (3) ASTM A 313/A 313M-08... approved for §§ 160.156-7 and 160.156-19 (“IMO Res. A.760(18)”). (3) Life-Saving Appliances, including LSA...

  10. 46 CFR 160.156-5 - Incorporation by reference.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... inspection at Coast Guard Headquarters. Contact Commandant (CG-ENG-4), Attn: Lifesaving and Fire Safety... Shapes, (approved October 1, 2008), IBR approved for § 160.156-7 (“ASTM A 276”). (3) ASTM A 313/A 313M-08... approved for §§ 160.156-7 and 160.156-19 (“IMO Res. A.760(18)”). (3) Life-Saving Appliances, including LSA...

  11. Motexafin lutetium-photodynamic therapy of prostate cancer: Short and long term effects on PSA

    PubMed Central

    Patel, Hiral; Mick, Rosemarie; Finlay, Jarod; Zhu, Timothy C.; Rickter, Elizabeth; Cengel, Keith A.; Malkowicz, S. Bruce; Hahn, Stephen M.; Busch, Theresa M.

    2009-01-01

    Purpose: The time course of serum PSA response to photodynamic therapy (PDT) of prostate cancer was measured. Experimental Design: Seventeen patients were treated in a Phase I trial of motexafin lutetium-PDT. PDT dose was calculated in each patient as the product of the ex vivo-measured pre-PDT photosensitizer level and the in situ-measured light dose. Serum PSA level was measured within two months prior to PDT (baseline), and at day 1; weeks 1-3; months 1, 2 and 3; months 4-6 and months 7-11 after PDT. Results: At 24h after PDT, serum PSA increased by 98±36% (mean ± SE) relative to baseline levels (p=0.007). When patients were dichotomized based on median PDT dose, those who received high PDT dose demonstrated a 119±52% increase in PSA compared to a 54±27% increase in patients treated at low PDT dose. Patients treated with high vs. low PDT dose demonstrated a median biochemical delay of 82 vs. 43 days (p=0.024), with biochemical delay defined as the length of time between PDT and a nonreversible increase in PSA to a value ≥baseline. Conclusions: Results show PDT to induce large, transient increases in serum PSA levels. Patients who experienced high PDT dose demonstrated greater short-term increase in PSA and a significantly more durable PSA response (biochemical delay). These data strongly promote the need for individualized delivery of PDT dose and assessment of treatment effect in PDT of prostate cancer. Information gained from such patient-specific measurements could facilitate the introduction of multiple PDT sessions in patients who would benefit. PMID:18676760

  12. Lutetium(III)-dependent self-assembly study of ciliate Euplotes octocarinatus centrin.

    PubMed

    Duan, Lian; Zhao, Ya-Qin; Wang, Zhi-Jun; Li, Guo-Ting; Liang, Ai-Hua; Yang, Bin-Sheng

    2008-02-01

    Ciliate Euplotes octocarinatus centrin (EoCen) is a member of the EF-hand superfamily of calcium-binding proteins, which often associated with the centrosomes and basal bodies. To explore the possible structural role of EoCen, we initiated a physicochemical study of the self-assembly properties of the purified protein in vitro. The native PAGE results indicate that only the integral protein shows multimers in the presence of Lu(3+). The dependence of Lu(3+) induced self-assembly of EoCen on various chemical and physical factors, including temperature, protein concentration, ionic strength and pH, was characterized using resonance light scattering (RLS). Control experiments with different metal ions suggest that Ca(2+) and Lu(3+) bindings to the N-terminal domain of EoCen are all positive to the self-assembly of the protein, and Lu(3+) exhibits the stronger effect, however, Mg(2+) alone cannot take the same effect. The experiments of 2-ptoluidinylnaphthalene-6-sulfonate (TNS) binding and ionic strength demonstrate that the lutetium(III)-dependent self-assembly is closely related to the exposure of hydrophobic cavity. Control experiment on pH value with EoCen and the fragments of it, N-terminal domain of EoCen (N-EoCen), indicates that the electrostatic effect is of small tendency to be served as the main driving force in the self-assembly of EoCen. The specific oligomerization form of the protein was exhibited by cross-linking experiment.

  13. Structural and electrochemical properties of lutetium bis-octachloro-phthalocyaninate nanostructured films. Application as voltammetric sensors.

    PubMed

    Alessio, P; Apetrei, C; Rubira, R J G; Constantino, C J L; Medina-Plazal, C; De Saja, J A; Rodríguez-Méndez, M L

    2014-09-01

    Thin films of the bis[2,3,9,10,16,17,23,24-octachlorophthalocyaninate] lutetium(III) complex (LuPc2Cl32) have been prepared by the Langmuir-Blodgett and the Langmuir-Schaefer (LS) techniques. The influence of the chlorine substituents in the structure of the films and in their spectroscopic, electrochemical and sensing properties has been evaluated. The π-A isotherms exhibit a monolayer stability greater than the observed in the unsubstituted analogue (LuPc2), being easily transferred to solid substrates, also in contrast to LuPc2. The LB and LS films present a linear growth forming stratified layers, monitored by UV-VIS absorption spectroscopy. The latter also revealed the presence of LuPc2Cl32 in the form of monomers and aggregates in both films. The FTIR data showed that the LuPc2Cl32 molecules present a non-preferential arrangement in both films. Monolayers of LB and LS were deposited onto 6 nm Ag island films to record surface-enhanced resonance Raman scattering (SERRS), leading to enhancement factors close to 2 x 10(3). Finally, LB and LS films deposited onto ITO glass have been successfully used as voltammetric sensors for the detection of catechol. The improved electroactivity of the LB and LS films has been confirmed by the reduction of the overpotential of the oxidation of catechol. The enhancement of the electrocatalytic effect observed in LB and LS films is the result of the nanostructured arrangement of the surface which increases the number of active sites. The sensors show a limit of detection in the range of 10(-5) mol/L.

  14. Early efficacy of and toxicity from lutetium-177-DOTATATE treatment in patients with progressive metastatic NET.

    PubMed

    Pencharz, Deborah; Walker, Martin; Yalchin, Mehmet; Quigley, Ann-Marie; Caplin, Martyn; Toumpanakis, Christos; Navalkissoor, Shaunak

    2017-07-01

    Lutetium-177 DOTA-D-Phe1-Tyr3-octreotide (Lu-DOTATATE) is a treatment option for patients with well-differentiated metastatic neuroendocrine tumours. Our centre started administering this therapy in 2012. The aim of this study was therefore to analyse the first cohort of patients treated with Lu-DOTATATE to determine its early efficacy and toxicity. We retrospectively analysed patient, tumour and treatment characteristics, end-of-treatment outcome, time to progression and toxicity in 79 consecutive patients treated with Lu-DOTATATE who had progressive NET according to Response Evaluation Criteria in Solid Tumours criteria. Follow-up time was 12-40 months. Study of Kaplan-Meier plots, analysis of time to progression and multiple regression analysis of factors predictive of time to progression were performed. At end-of-treatment radiological restaging, 13% of patients were found to have partial response and 64% to have stable disease; 23% of patients progressed through treatment. Overall, 47% of patients demonstrated a reduction in chromogranin A levels. The overall estimated median time to progression from the start of treatment was 28 months for the entire cohort and 31, 30 and 5 months for those with partial response, stable disease and progressive disease, respectively. On multivariate regression analysis, higher grade of tumour was found to be significantly associated with shorter progression-free survival. Three patients experienced grade 1 haematotoxicity, five grade 1 nephrotoxicity and one grade 2 nephrotoxicity. Early outcomes of patients treated with Lu-DOTATATE are similar to those in previously published series in terms of end-of-treatment efficacy and toxicity. This provides further evidence that this is a safe and efficacious form of treatment for patients with progressive metastatic neuroendocrine tumours.

  15. Investigation of high pressure phase transition and electronic properties of Lutetium Nitride

    NASA Astrophysics Data System (ADS)

    Singh, Sanjay Kumar; Verma, U. P.

    2015-09-01

    In the present manuscript we have investigated the structural, electronic and phase transition properties of the heaviest lanthanide lutetium nitride (LuN) compound using an ab initio calculations based on the density functional theory with Perdrew, Burke and Ernzerhof generalized gradient approximation (PBE-GGA) and Engel-Vosko(EV)-GGA as implemented in WIEN2k code. The basic ground state properties viz., lattice constants (a), bulk modulus (B0) and its pressure derivative (B0’) and total energy (E0) are calculated. The calculated values of lattice constant is 4.76 Å which is in good agreement with experimental value a= 4.76 A and other theoretical value. The relative stabilities of LuN at high pressures in the NaCl (B1), CsCl (B2), zinc blende (B3) and body centred tetragonal (BCT) structures are analysed. At compressed volumes, this compound is found to favour the CsCl phase rather the body centred tetragonal phase and zinc blende as observed in other lanthanum pnictides, which has been predicted by the total energy minimization. Under compression LuN undergoes a transition from NaCl to CsCl type structure at around 250.81 GPa with a volume collapse of 3.75%. To see the effect of functional we have also computed the band structure in B1 and B2 structure. Obtained result on band structure shows that LuN are semimetal by GGA while depicts semiconducting behaviour by EV-GGA. It shows metallic nature in B2 phase.

  16. Parameters for the RM1 Quantum Chemical Calculation of Complexes of the Trications of Thulium, Ytterbium and Lutetium

    PubMed Central

    Filho, Manoel A. M.; Dutra, José Diogo L.; Rocha, Gerd B.; Simas, Alfredo M.

    2016-01-01

    The RM1 quantum chemical model for the calculation of complexes of Tm(III), Yb(III) and Lu(III) is advanced. Subsequently, we tested the models by fully optimizing the geometries of 126 complexes. We then compared the optimized structures with known crystallographic ones from the Cambridge Structural Database. Results indicate that, for thulium complexes, the accuracy in terms of the distances between the lanthanide ion and its directly coordinated atoms is about 2%. Corresponding results for ytterbium and lutetium are both 3%, levels of accuracy useful for the design of lanthanide complexes, targeting their countless applications. PMID:27223475

  17. Parameters for the RM1 Quantum Chemical Calculation of Complexes of the Trications of Thulium, Ytterbium and Lutetium.

    PubMed

    Filho, Manoel A M; Dutra, José Diogo L; Rocha, Gerd B; Simas, Alfredo M; Freire, Ricardo O

    2016-01-01

    The RM1 quantum chemical model for the calculation of complexes of Tm(III), Yb(III) and Lu(III) is advanced. Subsequently, we tested the models by fully optimizing the geometries of 126 complexes. We then compared the optimized structures with known crystallographic ones from the Cambridge Structural Database. Results indicate that, for thulium complexes, the accuracy in terms of the distances between the lanthanide ion and its directly coordinated atoms is about 2%. Corresponding results for ytterbium and lutetium are both 3%, levels of accuracy useful for the design of lanthanide complexes, targeting their countless applications.

  18. 46 CFR 160.156-21 - Operation and maintenance instructions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 6 2014-10-01 2014-10-01 false Operation and maintenance instructions. 160.156-21 Section 160.156-21 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) EQUIPMENT, CONSTRUCTION, AND MATERIALS: SPECIFICATIONS AND APPROVAL LIFESAVING EQUIPMENT Rescue Boats and Fast Rescue...

  19. 46 CFR 160.156-21 - Operation and maintenance instructions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 6 2012-10-01 2012-10-01 false Operation and maintenance instructions. 160.156-21 Section 160.156-21 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) EQUIPMENT, CONSTRUCTION, AND MATERIALS: SPECIFICATIONS AND APPROVAL LIFESAVING EQUIPMENT Rescue Boats and Fast Rescue...

  20. 40 CFR 156.85 - Non-target organisms.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Non-target organisms. 156.85 Section 156.85 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS... Non-target organisms. (a) Requirement. Where a hazard exists to non-target organisms, EPA may...

  1. 40 CFR 156.85 - Non-target organisms.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 24 2011-07-01 2011-07-01 false Non-target organisms. 156.85 Section 156.85 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS... Non-target organisms. (a) Requirement. Where a hazard exists to non-target organisms, EPA may...

  2. 33 CFR 156.118 - Advance notice of transfer.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Advance notice of transfer. 156... (CONTINUED) POLLUTION OIL AND HAZARDOUS MATERIAL TRANSFER OPERATIONS Oil and Hazardous Material Transfer Operations § 156.118 Advance notice of transfer. (a) The COTP may require a facility operator to notify the...

  3. 40 CFR 408.156 - Pretreatment standards for new sources.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 28 2010-07-01 2010-07-01 true Pretreatment standards for new sources. 408.156 Section 408.156 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS CANNED AND PRESERVED SEAFOOD PROCESSING POINT SOURCE CATEGORY Fish Meal...

  4. 40 CFR 60.156 - Delegation of authority.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 6 2010-07-01 2010-07-01 false Delegation of authority. 60.156 Section 60.156 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) STANDARDS OF PERFORMANCE FOR NEW STATIONARY SOURCES Standards of Performance for Sewage Treatment...

  5. 45 CFR 156.80 - Single risk pool.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 1 2013-10-01 2013-10-01 false Single risk pool. 156.80 Section 156.80 Public... adjustments to the index rate. For plan years or policy years beginning on or after January 1, 2014, a health... January 1, 2014. ...

  6. 45 CFR 156.130 - Cost-sharing requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 1 2013-10-01 2013-10-01 false Cost-sharing requirements. 156.130 Section 156.130...) For a plan year beginning in the calendar year 2014, cost sharing may not exceed the following: (i... Internal Revenue Code of 1986 as amended, for self-only coverage that that is in effect for 2014; or (ii...

  7. 45 CFR 156.800 - Available remedies; Scope.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 1 2013-10-01 2013-10-01 false Available remedies; Scope. 156.800 Section 156.800 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS HEALTH... Exchange. (c) Compliance standard. For 2014, sanctions under this subpart will not be imposed if the QHP...

  8. 45 CFR 156.210 - QHP rate and benefit information.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 1 2012-10-01 2012-10-01 false QHP rate and benefit information. 156.210 Section 156.210 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE... justification on its Web site. ...

  9. 9 CFR 156.1 - Meaning of words.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Meaning of words. 156.1 Section 156.1 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... Meaning of words. Words used in this part in the singular form shall import the plural, and vice versa, as...

  10. 45 CFR 156.10 - Basis and scope.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 1 2014-10-01 2014-10-01 false Basis and scope. 156.10 Section 156.10 Public Welfare Department of Health and Human Services REQUIREMENTS RELATING TO HEALTH CARE ACCESS HEALTH... on section 1150A, Pharmacy Benefit Managers Transparency Requirements, of title I of the Act: (b...

  11. 45 CFR 156.10 - Basis and scope.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 1 2013-10-01 2013-10-01 false Basis and scope. 156.10 Section 156.10 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS HEALTH... on section 1150A, Pharmacy Benefit Managers Transparency Requirements, of title I of the Act: (b...

  12. 45 CFR 156.10 - Basis and scope.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 1 2012-10-01 2012-10-01 false Basis and scope. 156.10 Section 156.10 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS HEALTH... on section 1150A, Pharmacy Benefit Managers Transparency Requirements, of title I of the Act: (b...

  13. 12 CFR 252.156 - Reports of stress test results.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 4 2014-01-01 2014-01-01 false Reports of stress test results. 252.156 Section... SYSTEM (CONTINUED) ENHANCED PRUDENTIAL STANDARDS (REGULATION YY) Company-Run Stress Test Requirements for....156 Reports of stress test results. (a) Reports to the Board of stress test results—(1) Savings...

  14. 12 CFR 252.156 - Reports of stress test results.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 4 2013-01-01 2013-01-01 false Reports of stress test results. 252.156 Section... SYSTEM (CONTINUED) ENHANCED PRUDENTIAL STANDARDS (REGULATION YY) Company-Run Stress Test Requirements for....156 Reports of stress test results. (a) Reports to the Board of stress test results—(1) Savings...

  15. 45 CFR 156.250 - Health plan applications and notices.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 1 2013-10-01 2013-10-01 false Health plan applications and notices. 156.250 Section 156.250 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS HEALTH INSURANCE ISSUER STANDARDS UNDER THE AFFORDABLE CARE ACT, INCLUDING...

  16. 33 CFR 156.170 - Equipment tests and inspections.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Equipment tests and inspections. 156.170 Section 156.170 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) POLLUTION OIL AND HAZARDOUS MATERIAL TRANSFER OPERATIONS Oil and Hazardous Material...

  17. 45 CFR 156.1120 - Quality rating system.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 1 2014-10-01 2014-10-01 false Quality rating system. 156.1120 Section 156.1120 Public Welfare Department of Health and Human Services REQUIREMENTS RELATING TO HEALTH CARE ACCESS HEALTH INSURANCE ISSUER STANDARDS UNDER THE AFFORDABLE CARE ACT, INCLUDING STANDARDS RELATED TO EXCHANGES Quality...

  18. 45 CFR 156.1125 - Enrollee satisfaction survey system.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 1 2014-10-01 2014-10-01 false Enrollee satisfaction survey system. 156.1125 Section 156.1125 Public Welfare Department of Health and Human Services REQUIREMENTS RELATING TO HEALTH CARE ACCESS HEALTH INSURANCE ISSUER STANDARDS UNDER THE AFFORDABLE CARE ACT, INCLUDING STANDARDS...

  19. 27 CFR 19.156 - Powers of attorney.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Powers of attorney. 19.156 Section 19.156 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT... Powers of attorney. The proprietor shall execute and file with the appropriate TTB officer a Form...

  20. 40 CFR 156.85 - Non-target organisms.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 24 2014-07-01 2014-07-01 false Non-target organisms. 156.85 Section 156.85 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS... Non-target organisms. (a) Requirement. Where a hazard exists to non-target organisms, EPA may require...

  1. 40 CFR 156.85 - Non-target organisms.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 25 2013-07-01 2013-07-01 false Non-target organisms. 156.85 Section 156.85 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS... Non-target organisms. (a) Requirement. Where a hazard exists to non-target organisms, EPA may require...

  2. 14 CFR 156.4 - Airport and project eligibility.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Airport and project eligibility. 156.4... (CONTINUED) AIRPORTS STATE BLOCK GRANT PILOT PROGRAM § 156.4 Airport and project eligibility. (a) A participating State shall use monies distributed pursuant to a State block grant agreement for airport...

  3. 14 CFR 156.4 - Airport and project eligibility.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Airport and project eligibility. 156.4... (CONTINUED) AIRPORTS STATE BLOCK GRANT PILOT PROGRAM § 156.4 Airport and project eligibility. (a) A participating State shall use monies distributed pursuant to a State block grant agreement for airport...

  4. 14 CFR 156.4 - Airport and project eligibility.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Airport and project eligibility. 156.4... (CONTINUED) AIRPORTS STATE BLOCK GRANT PILOT PROGRAM § 156.4 Airport and project eligibility. (a) A participating State shall use monies distributed pursuant to a State block grant agreement for airport...

  5. 14 CFR 156.4 - Airport and project eligibility.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Airport and project eligibility. 156.4... (CONTINUED) AIRPORTS STATE BLOCK GRANT PILOT PROGRAM § 156.4 Airport and project eligibility. (a) A participating State shall use monies distributed pursuant to a State block grant agreement for airport...

  6. 14 CFR 156.4 - Airport and project eligibility.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Airport and project eligibility. 156.4... (CONTINUED) AIRPORTS STATE BLOCK GRANT PILOT PROGRAM § 156.4 Airport and project eligibility. (a) A participating State shall use monies distributed pursuant to a State block grant agreement for airport...

  7. 9 CFR 156.1 - Meaning of words.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Meaning of words. 156.1 Section 156.1 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... Meaning of words. Words used in this part in the singular form shall import the plural, and vice versa,...

  8. 9 CFR 156.1 - Meaning of words.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Meaning of words. 156.1 Section 156.1 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... Meaning of words. Words used in this part in the singular form shall import the plural, and vice versa,...

  9. 9 CFR 156.1 - Meaning of words.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Meaning of words. 156.1 Section 156.1 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... Meaning of words. Words used in this part in the singular form shall import the plural, and vice versa,...

  10. 9 CFR 156.1 - Meaning of words.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Meaning of words. 156.1 Section 156.1 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... Meaning of words. Words used in this part in the singular form shall import the plural, and vice versa,...

  11. 40 CFR 156.85 - Non-target organisms.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 25 2012-07-01 2012-07-01 false Non-target organisms. 156.85 Section 156.85 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS... Non-target organisms. (a) Requirement. Where a hazard exists to non-target organisms, EPA may require...

  12. 24 CFR 3282.156 - Petitions for investigations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Petitions for investigations. 3282.156 Section 3282.156 Housing and Urban Development Regulations Relating to Housing and Urban... HOUSING AND URBAN DEVELOPMENT MANUFACTURED HOME PROCEDURAL AND ENFORCEMENT REGULATIONS Informal and...

  13. 44 CFR 15.6 - Compliance with signs and directions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Compliance with signs and directions. 15.6 Section 15.6 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY... the NETC must comply at all times with official signs that prohibit, regulate, or direct, and with the...

  14. 42 CFR 423.156 - Consumer satisfaction surveys.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 3 2013-10-01 2013-10-01 false Consumer satisfaction surveys. 423.156 Section 423... Quality Improvement Requirements § 423.156 Consumer satisfaction surveys. Part D contracts with 600 or more enrollees as of July of the prior year must contract with approved Medicare Consumer Assessment of...

  15. 42 CFR 423.156 - Consumer satisfaction surveys.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Consumer satisfaction surveys. 423.156 Section 423... Improvement Requirements § 423.156 Consumer satisfaction surveys. Part D contracts with 600 or more enrollees as of July of the prior year must contract with approved Medicare Consumer Assessment of Healthcare...

  16. 42 CFR 423.156 - Consumer satisfaction surveys.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false Consumer satisfaction surveys. 423.156 Section 423... Quality Improvement Requirements § 423.156 Consumer satisfaction surveys. Part D contracts with 600 or more enrollees as of July of the prior year must contract with approved Medicare Consumer Assessment of...

  17. 42 CFR 423.156 - Consumer satisfaction surveys.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Consumer satisfaction surveys. 423.156 Section 423... Quality Improvement Requirements § 423.156 Consumer satisfaction surveys. Part D contracts with 600 or more enrollees as of July of the prior year must contract with approved Medicare Consumer Assessment of...

  18. 45 CFR 156.250 - Health plan applications and notices.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 1 2014-10-01 2014-10-01 false Health plan applications and notices. 156.250 Section 156.250 Public Welfare Department of Health and Human Services REQUIREMENTS RELATING TO HEALTH CARE ACCESS HEALTH INSURANCE ISSUER STANDARDS UNDER THE AFFORDABLE CARE ACT, INCLUDING STANDARDS...

  19. 40 CFR 156.66 - Child hazard warning.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 24 2011-07-01 2011-07-01 false Child hazard warning. 156.66 Section... LABELING REQUIREMENTS FOR PESTICIDES AND DEVICES Human Hazard and Precautionary Statements § 156.66 Child... Out of Reach of Children.” That statement, or any alternative statement approved by EPA, must appear...

  20. 40 CFR 156.66 - Child hazard warning.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 25 2013-07-01 2013-07-01 false Child hazard warning. 156.66 Section... LABELING REQUIREMENTS FOR PESTICIDES AND DEVICES Human Hazard and Precautionary Statements § 156.66 Child... Out of Reach of Children.” That statement, or any alternative statement approved by EPA, must appear...

  1. 40 CFR 156.66 - Child hazard warning.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 24 2014-07-01 2014-07-01 false Child hazard warning. 156.66 Section... LABELING REQUIREMENTS FOR PESTICIDES AND DEVICES Human Hazard and Precautionary Statements § 156.66 Child... Out of Reach of Children.” That statement, or any alternative statement approved by EPA, must appear...

  2. 40 CFR 156.66 - Child hazard warning.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 25 2012-07-01 2012-07-01 false Child hazard warning. 156.66 Section... LABELING REQUIREMENTS FOR PESTICIDES AND DEVICES Human Hazard and Precautionary Statements § 156.66 Child... Out of Reach of Children.” That statement, or any alternative statement approved by EPA, must appear...

  3. 42 CFR 423.156 - Consumer satisfaction surveys.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Consumer satisfaction surveys. 423.156 Section 423... Improvement Requirements § 423.156 Consumer satisfaction surveys. Part D contracts with 600 or more enrollees... Providers and Systems (CAHPS) survey vendors to conduct the Medicare CAHPS satisfaction survey of Part...

  4. 42 CFR 53.156 - Fees for modification requests.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Fees for modification requests. 53.156 Section 53.156 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS GRANTS, LOANS AND LOAN GUARANTEES FOR CONSTRUCTION AND MODERNIZATION OF HOSPITALS AND MEDICAL FACILITIES Loan...

  5. 30 CFR 75.156 - AMS operator, qualifications.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false AMS operator, qualifications. 75.156 Section 75... HEALTH MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Qualified and Certified Persons § 75.156 AMS operator, qualifications. (a) To be qualified as an AMS operator, a person shall be provided with...

  6. 40 CFR 408.156 - Pretreatment standards for new sources.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 30 2012-07-01 2012-07-01 false Pretreatment standards for new sources. 408.156 Section 408.156 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS CANNED AND PRESERVED SEAFOOD PROCESSING POINT SOURCE CATEGORY Fish Meal Processing...

  7. 40 CFR 408.156 - Pretreatment standards for new sources.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 30 2013-07-01 2012-07-01 true Pretreatment standards for new sources. 408.156 Section 408.156 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS CANNED AND PRESERVED SEAFOOD PROCESSING POINT SOURCE CATEGORY Fish Meal Processing...

  8. 40 CFR 408.156 - Pretreatment standards for new sources.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 29 2011-07-01 2009-07-01 true Pretreatment standards for new sources. 408.156 Section 408.156 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS CANNED AND PRESERVED SEAFOOD PROCESSING POINT SOURCE CATEGORY Fish Meal Processing...

  9. 40 CFR 408.156 - Pretreatment standards for new sources.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 29 2014-07-01 2012-07-01 true Pretreatment standards for new sources. 408.156 Section 408.156 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS CANNED AND PRESERVED SEAFOOD PROCESSING POINT SOURCE CATEGORY Fish Meal Processing...

  10. 7 CFR 1717.156 - Transitional assistance affecting preexisting loans.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 11 2011-01-01 2011-01-01 false Transitional assistance affecting preexisting loans. 1717.156 Section 1717.156 Agriculture Regulations of the Department of Agriculture (Continued) RURAL... affecting preexisting loans. The fund advance period for an insured loan, which is the period during which...

  11. 7 CFR 1717.156 - Transitional assistance affecting preexisting loans.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 11 2010-01-01 2010-01-01 false Transitional assistance affecting preexisting loans. 1717.156 Section 1717.156 Agriculture Regulations of the Department of Agriculture (Continued) RURAL... affecting preexisting loans. The fund advance period for an insured loan, which is the period during which...

  12. 7 CFR 1717.156 - Transitional assistance affecting preexisting loans.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 11 2013-01-01 2013-01-01 false Transitional assistance affecting preexisting loans. 1717.156 Section 1717.156 Agriculture Regulations of the Department of Agriculture (Continued) RURAL... affecting preexisting loans. The fund advance period for an insured loan, which is the period during which...

  13. 7 CFR 1717.156 - Transitional assistance affecting preexisting loans.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 11 2014-01-01 2014-01-01 false Transitional assistance affecting preexisting loans. 1717.156 Section 1717.156 Agriculture Regulations of the Department of Agriculture (Continued) RURAL... affecting preexisting loans. The fund advance period for an insured loan, which is the period during which...

  14. 7 CFR 1717.156 - Transitional assistance affecting preexisting loans.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 11 2012-01-01 2012-01-01 false Transitional assistance affecting preexisting loans. 1717.156 Section 1717.156 Agriculture Regulations of the Department of Agriculture (Continued) RURAL... affecting preexisting loans. The fund advance period for an insured loan, which is the period during which...

  15. 7 CFR 1150.156 - Charges and penalties.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 9 2010-01-01 2009-01-01 true Charges and penalties. 1150.156 Section 1150.156 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Milk), DEPARTMENT OF AGRICULTURE DAIRY PROMOTION PROGRAM Dairy Promotion and Research...

  16. 7 CFR 1150.156 - Charges and penalties.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 9 2014-01-01 2013-01-01 true Charges and penalties. 1150.156 Section 1150.156 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; MILK), DEPARTMENT OF AGRICULTURE DAIRY PROMOTION PROGRAM Dairy Promotion and Research...

  17. 47 CFR 25.156 - Consideration of applications.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 25.156 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES SATELLITE COMMUNICATIONS Applications and Licenses Processing of Applications § 25.156 Consideration of... establishes NGSO/GSO sharing criteria for that frequency band. In the event that the Commission receives...

  18. 40 CFR 156.208 - Restricted-entry statements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... acceptable exposure level) shall be retained. Entry restrictions for fumigants have been or shall be... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Restricted-entry statements. 156.208... LABELING REQUIREMENTS FOR PESTICIDES AND DEVICES Worker Protection Statements § 156.208...

  19. 40 CFR 156.208 - Restricted-entry statements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... acceptable exposure level) shall be retained. Entry restrictions for fumigants have been or shall be... 40 Protection of Environment 25 2012-07-01 2012-07-01 false Restricted-entry statements. 156.208... LABELING REQUIREMENTS FOR PESTICIDES AND DEVICES Worker Protection Statements § 156.208...

  20. 40 CFR 156.208 - Restricted-entry statements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... acceptable exposure level) shall be retained. Entry restrictions for fumigants have been or shall be... 40 Protection of Environment 24 2011-07-01 2011-07-01 false Restricted-entry statements. 156.208... LABELING REQUIREMENTS FOR PESTICIDES AND DEVICES Worker Protection Statements § 156.208...

  1. 40 CFR 156.208 - Restricted-entry statements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... acceptable exposure level) shall be retained. Entry restrictions for fumigants have been or shall be... 40 Protection of Environment 25 2013-07-01 2013-07-01 false Restricted-entry statements. 156.208... LABELING REQUIREMENTS FOR PESTICIDES AND DEVICES Worker Protection Statements § 156.208...

  2. 30 CFR 1206.156 - Transportation allowances-general.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 3 2011-07-01 2011-07-01 false Transportation allowances-general. 1206.156... INTERIOR Natural Resources Revenue PRODUCT VALUATION Federal Gas § 1206.156 Transportation allowances..., and gas plant products from a lease to a point off the lease including, if appropriate, transportation...

  3. 40 CFR 156.66 - Child hazard warning.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 156.66 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS LABELING REQUIREMENTS FOR PESTICIDES AND DEVICES Human Hazard and Precautionary Statements § 156.66 Child hazard warning. (a) Each pesticide product must bear on the front panel of the label the statement “Keep...

  4. 40 CFR 159.156 - How information must be submitted.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ....156 Section 159.156 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS STATEMENTS OF POLICIES AND INTERPRETATIONS Reporting Requirements for Risk/Benefit Information... to the Office of Pesticide Programs' Document Processing Desk at the appropriate address as set...

  5. 40 CFR 156.200 - Scope and applicability.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Section 156.200 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS LABELING REQUIREMENTS FOR PESTICIDES AND DEVICES Worker Protection Statements § 156.200 Scope and applicability. (a) Scope. (1) This subpart prescribes statements that must be placed on the pesticide label...

  6. 40 CFR 159.156 - How information must be submitted.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ....156 Section 159.156 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS STATEMENTS OF POLICIES AND INTERPRETATIONS Reporting Requirements for Risk/Benefit Information... to the Office of Pesticide Programs' Document Processing Desk at the appropriate address as set...

  7. 40 CFR 156.200 - Scope and applicability.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Section 156.200 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS LABELING REQUIREMENTS FOR PESTICIDES AND DEVICES Worker Protection Statements § 156.200 Scope and applicability. (a) Scope. (1) This subpart prescribes statements that must be placed on the pesticide label...

  8. 40 CFR 156.200 - Scope and applicability.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Section 156.200 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS LABELING REQUIREMENTS FOR PESTICIDES AND DEVICES Worker Protection Statements § 156.200 Scope and applicability. (a) Scope. (1) This subpart prescribes statements that must be placed on the pesticide label...

  9. 40 CFR 159.156 - How information must be submitted.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ....156 Section 159.156 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS STATEMENTS OF POLICIES AND INTERPRETATIONS Reporting Requirements for Risk/Benefit Information... to the Office of Pesticide Programs' Document Processing Desk at the appropriate address as set...

  10. 40 CFR 156.200 - Scope and applicability.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Section 156.200 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS LABELING REQUIREMENTS FOR PESTICIDES AND DEVICES Worker Protection Statements § 156.200 Scope and applicability. (a) Scope. (1) This subpart prescribes statements that must be placed on the pesticide label...

  11. 40 CFR 156.200 - Scope and applicability.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Section 156.200 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS LABELING REQUIREMENTS FOR PESTICIDES AND DEVICES Worker Protection Statements § 156.200 Scope and applicability. (a) Scope. (1) This subpart prescribes statements that must be placed on the pesticide label...

  12. 40 CFR 159.156 - How information must be submitted.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ....156 Section 159.156 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS STATEMENTS OF POLICIES AND INTERPRETATIONS Reporting Requirements for Risk/Benefit Information... to the Office of Pesticide Programs' Document Processing Desk at the appropriate address as set...

  13. 40 CFR 159.156 - How information must be submitted.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ....156 Section 159.156 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS STATEMENTS OF POLICIES AND INTERPRETATIONS Reporting Requirements for Risk/Benefit Information... to the Office of Pesticide Programs' Document Processing Desk at the appropriate address as set...

  14. 45 CFR 156.260 - Enrollment periods for qualified individuals.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ....260 Section 156.260 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS HEALTH INSURANCE ISSUER STANDARDS UNDER THE AFFORDABLE CARE ACT, INCLUDING STANDARDS RELATED TO EXCHANGES Qualified Health Plan Minimum Certification Standards § 156.260 Enrollment...

  15. 45 CFR 156.250 - Health plan applications and notices.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 1 2012-10-01 2012-10-01 false Health plan applications and notices. 156.250 Section 156.250 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS HEALTH INSURANCE ISSUER STANDARDS UNDER THE AFFORDABLE CARE ACT, INCLUDING...

  16. 45 CFR 156.265 - Enrollment process for qualified individuals.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ....265 Section 156.265 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS HEALTH INSURANCE ISSUER STANDARDS UNDER THE AFFORDABLE CARE ACT, INCLUDING STANDARDS RELATED TO EXCHANGES Qualified Health Plan Minimum Certification Standards § 156.265 Enrollment...

  17. 18 CFR 156.3 - Applications; general requirements.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 18 Conservation of Power and Water Resources 1 2014-04-01 2014-04-01 false Applications; general requirements. 156.3 Section 156.3 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY... convenience and necessity, franchise or other authorization which applicant has applied for or received from...

  18. Piano-stool lutetium amido and imido compounds supported by a constrained bis(oxazoline)cyclopentadienyl ligand

    DOE PAGES

    Lampland, Nicole L.; Zhu, Jing; Hovey, Megan; ...

    2015-06-25

    {BoMCptet}Lu(CH2Ph)2 (1; BoMCptet = MeC(OxMe2 2C5Me4; OxMe2 = 4,4-dimethyl-2-oxazoline) was prepared in 95% yield from the reaction of BoMCptetH and Lu(CH2Ph)3THF3. Compound 1 reacts with 1 or 2 equiv of H2NCH2R (R = C6H5, 1-C10H7) to give the corresponding imido complexes [{BoMCptet}LuNCH2R]2 (R = C6H5 (2a), 1-C10H7 (2b)) or amido complexes {BoMCptet}Lu(NHCH2R)2 (R = C6H5 (3a), 1-C10H7 (3b)). When isolated, the imido species are insoluble in nonprotic organic solvents. Crystallographic characterization reveals dimeric [{BoMCptet}LuNCH2(1-C10H7)]2 in the solid state. The reaction of 1 and NH3B(C6F5)3 affords crystallographically characterized {BoMCptet}Lu{NHB(C6F5)2}C6F5. This species is proposed to form via a transient lutetium imido, whichmore » undergoes C6F5 migration to the lutetium center.« less

  19. ABAB homoleptic bis(phthalocyaninato)lutetium(III) complex: toward the real octupolar cube and giant quadratic hyperpolarizability.

    PubMed

    Ayhan, Mehmet Menaf; Singh, Anu; Hirel, Catherine; Gürek, Ayşe Gül; Ahsen, Vefa; Jeanneau, Erwann; Ledoux-Rak, Isabelle; Zyss, Joseph; Andraud, Chantal; Bretonnière, Yann

    2012-02-29

    The concept of octupolar molecules has considerably enlarged the engineering of second-order nonlinear optical materials by giving access to 2D and 3D architectures. However, if the archetype of octupolar symmetry is a cube with alternating donor and acceptor groups at the corners, no translation of this ideal structure into a real molecule has been realized to date. This may be achieved by designing a bis(phthalocyaninato)lutetium(III) double-decker complex with a crosswise ABAB phthalocyanine bearing alternating electron-donor and electron-acceptor groups. In this communication, we present the first step toward this goal with the synthesis, crystal structure determination, and measurement of the molecular first-order hyperpolarizability β by harmonic light diffusion, of an original lutetium(III) sandwich complex displaying the required ABAB-type alternation for one face of the cube. This structure is characterized by an intense absorption in the near-IR due to an intervalence transition and exhibits the highest quadratic hyperpolarizability ever reported for an octupolar molecule, √<β(2)(HLS)> = 5750 × 10(-30) esu.

  20. Anti-biofouling polymer-decorated lutetium-based nanoparticulate contrast agents for in vivo high-resolution trimodal imaging.

    PubMed

    Liu, Zhen; Dong, Kai; Liu, Jianhua; Han, Xueli; Ren, Jinsong; Qu, Xiaogang

    2014-06-25

    Nanomaterials have gained considerable attention and interest in the development of novel and high-resolution contrast agents for medical diagnosis and prognosis in clinic. A classical urea-based homogeneous precipitation route that combines the merits of in situ thermal decomposition and surface modification is introduced to construct polyethylene glycol molecule (PEG)-decorated hybrid lutetium oxide nanoparticles (PEG-UCNPs). By utilizing the admirable optical and magnetic properties of the yielded PEG-UCNPs, in vivo up-conversion luminescence and T1 -enhanced magnetic resonance imaging of small animals are conducted, revealing obvious signals after subcutaneous and intravenous injection, respectively. Due to the strong X-ray absorption and high atomic number of lanthanide elements, X-ray computed-tomography imaging based on PEG-UCNPs is then designed and carried out, achieving excellent imaging outcome in animal experiments. This is the first example of the usage of hybrid lutetium oxide nanoparticles as effective nanoprobes. Furthermore, biodistribution, clearance route, as well as long-term toxicity are investigated in detail after intravenous injection in a murine model, indicating the overall safety of PEG-UCNPs. Compared with previous lanthanide fluorides, our nanoprobes exhibit more advantages, such as facile construction process and nearly total excretion from the animal body within a month. Taken together, these results promise the use of PEG-UCNPs as a safe and efficient nanoparticulate contrast agent for potential application in multimodal imaging. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  1. High-phasing-power lanthanide derivatives: taking advantage of ytterbium and lutetium for optimized anomalous diffraction experiments using synchrotron radiation.

    PubMed

    Girard, E; Anelli, P L; Vicat, J; Kahn, R

    2003-10-01

    Ytterbium and lutetium are well suited for optimized anomalous diffraction experiments using synchrotron radiation. Therefore, two lanthanide complexes Yb-HPDO3A and Lu-HPDO3A have been produced that are similar to the Gd-HPDO3A complex already known to give good derivative crystals. Derivative crystals of hen egg-white lysozyme were obtained by co-crystallization using 100 mM solutions of each lanthanide complex. De novo phasing has been carried out using single-wavelength anomalous diffraction on data sets collected on each derivative crystal at the L(III) absorption edge of the corresponding lanthanide (ff" = 28 e(-)). A third data set was collected on a Lu-HPDO3A derivative crystal at the Se K absorption edge with f"(Lu) = 10 e(-). The structures were refined and compared with the known structure of the Gd-HPDO3A lysozyme derivative. The quality of the experimental electron-density maps allows easy model building. With L(III) absorption edges at shorter wavelengths than the gadolinium absorption edge, lutetium and ytterbium, when chelated by a ligand such as HPDO3A, form lanthanide complexes that are especially interesting for synchrotron-radiation experiments in structural biology.

  2. Piano-Stool Lutetium Amido and Imido Compounds Supported by a Constrained Bis(oxazoline)cyclopentadienyl Ligand.

    PubMed

    Lampland, Nicole L; Zhu, Jing; Hovey, Megan; Jana, Barun; Ellern, Arkady; Sadow, Aaron D

    2015-07-20

    {Bo(M)Cp(tet)}Lu(CH2Ph)2 (1; Bo(M)Cp(tet) = MeC(Ox(Me2))2C5Me4; Ox(Me2) = 4,4-dimethyl-2-oxazoline) was prepared in 95% yield from the reaction of Bo(M)Cp(tet)H and Lu(CH2Ph)3THF3. Compound 1 reacts with 1 or 2 equiv of H2NCH2R (R = C6H5, 1-C10H7) to give the corresponding imido complexes [{Bo(M)Cp(tet)}LuNCH2R]2 (R = C6H5 (2a), 1-C10H7 (2b)) or amido complexes {Bo(M)Cp(tet)}Lu(NHCH2R)2 (R = C6H5 (3a), 1-C10H7 (3b)). Once isolated, the imido species are insoluble in nonprotic organic solvents. Crystallographic characterization reveals dimeric [{Bo(M)Cp(tet)}LuNCH2(1-C10H7)]2 in the solid state. The reaction of 1 and NH3B(C6F5)3 affords crystallographically characterized {Bo(M)Cp(tet)}Lu{NHB(C6F5)2}C6F5. This species is proposed to form via a transient lutetium imido, which undergoes C6F5 migration to the lutetium center.

  3. Lutetium oxyorthosilicate block detector readout by avalanche photodiode arrays for high resolution animal PET.

    PubMed

    Pichler, B J; Swann, B K; Rochelle, J; Nutt, R E; Cherry, S R; Siegel, S B

    2004-09-21

    Avalanche photodiodes (APDs) have proven to be useful as light detectors for high resolution positron emission tomography (PET). Their compactness makes these devices excellent candidates for replacing bulky photomultiplier tubes (PMTs) in PET systems where space limitations are an issue. The readout of densely packed, 10 x 10 lutetium oxyorthosilicate (LSO) block detectors (crystal size 2.0 x 2.0 x 12 mm3) with custom-built monolithic 3 x 3 APD arrays was investigated. The APDs had a 5 x 5 mm2 active surface and were arranged on a 6.25 mm pitch. The dead space on the edges of the array was 1.25 mm. The APDs were operated at a bias voltage of approximately 380 V for a gain of 100 and a dark current of 10 nA per APD. The standard deviation in gain between the APDs in the array ranged from 1.8 to 6.5% as the gain was varied from 50 to 108. A fast, low-noise, multi-channel charge sensitive preamplifier application-specific integrated circuit (ASIC) was developed for the APD readout. The amplifier had a rise time of 8 ns, a noise floor of 515 e- rms and a 9 e- pF(-1) noise slope. An acquired flood image showed that all 100 crystals from the block detector could be resolved. Timing measurements with single-channel LSO-APD detectors, as well as with the array, against a plastic scintillator and PMT assembly showed a time resolution of 1.2 ns and 2.5 ns, respectively. The energy resolution measured with a single 4.0 x 4.0 x 10 mm3 LSO crystal, wrapped in four-layer polytetrafluoroethylene (PTFE) tape and coupled with optical grease on a single APD of the array, yielded 15% (full width at half maximum, FWHM) at 511 keV. Stability tests over 9 months of operation showed that the APD arrays do not degrade appreciably. These results demonstrate the ability to decode densely packed LSO scintillation blocks with compact APD arrays. The good timing and energy resolution makes these detectors suitable for high resolution PET.

  4. Optimizing imaging protocols for overweight and obese patients: a lutetium orthosilicate PET/CT study.

    PubMed

    Halpern, Benjamin S; Dahlbom, Magnus; Auerbach, Martin A; Schiepers, Christiaan; Fueger, Barbara J; Weber, Wolfgang A; Silverman, Daniel H S; Ratib, Osman; Czernin, Johannes

    2005-04-01

    High photon attenuation and scatter in obese patients affect image quality. The purpose of the current study was to optimize lutetium orthosilicate (LSO) PET image acquisition protocols in patients weighing > or =91 kg (200 lb). Twenty-five consecutive patients (16 male and 9 female) weighing > or =91 kg (200 lb; range, 91-168 kg [200-370 lb]) were studied with LSO PET/CT. After intravenous injection of 7.77 MBq (0.21 mCi) of 18F-FDG per kilogram of body weight, PET emission scans were acquired for 7 min/bed position. Single-minute frames were extracted from the 7 min/bed position scans to reconstruct 1-7 min/bed position scans for each patient. Three reviewers independently analyzed all 7 reconstructed whole-body images of each patient. A consensus reading followed in cases of disagreement. Thus, 175 whole-body scans (7 per patient) were analyzed for number of hypermetabolic lesions. A region-of-interest approach was used to obtain a quantitative estimate of image quality. Fifty-nine hypermetabolic lesions identified on 7 min/bed position scans served as the reference standard. Interobserver concordance increased from 64% for 1 min/bed position scans to 70% for 3 min/bed position scans and 78% for 4 min/bed position scans. Concordance rates did not change for longer imaging durations. Region-of-interest analysis revealed that image noise decreased from 21% for 1 min/bed position scans to 14%, 13%, and 11% for, respectively, 4, 5, and 7 min/bed position scans. When compared with the reference standard, 14 lesions (24%) were missed on 1 min/bed position scans but only 2 (3%) on 4 min/bed position scans. Five minute/bed position scans were sufficient to detect all lesions identified on the 7 min/bed position scans. Lesion detectability and reader concordance peaked for 5 min/bed position scans, with no further diagnostic gain achieved by lengthening the duration of PET emission scanning. Thus, 5 min/bed position scans are sufficient for optimal lesion detection with

  5. Bis(tetrabenzotriazaporphyrinato) and (tetrabenzotriazaporphyrinato)(phthalocyaninato) lutetium(III) complexes--novel sandwich-type tetrapyrrolic ligand based NIR absorbing electrochromes.

    PubMed

    Pushkarev, Victor E; Kalashnikov, Valery V; Trashin, Stanislav A; Borisova, Nataliya E; Tomilova, Larisa G; Zefirov, Nikolay S

    2013-09-14

    The first sandwich-type complexes have been prepared for tetrabenzotriazaporphyrin ligands. The compounds reveal intrinsic UV-Vis/NIR absorption as well as peculiar electrochromic behavior. The heteroleptic (tetrabenzotriazaporphyrinato)(phthalocyaninato) lutetium derivative shows intermediate spectral and electrochemical properties with respect to homoleptic relatives.

  6. Influence of cations on the complexation yield of DOTATATE with yttrium and lutetium: a perspective study for enhancing the 90Y and 177Lu labeling conditions.

    PubMed

    Asti, Mattia; Tegoni, Matteo; Farioli, Daniela; Iori, Michele; Guidotti, Claudio; Cutler, Cathy S; Mayer, Pat; Versari, Annibale; Salvo, Diana

    2012-05-01

    The DOTA macrocyclic ligand can form stable complexes with many cations besides yttrium and lutetium. For this reason, the presence of competing cationic metals in yttrium-90 and lutetium-177 chloride solutions can dramatically influence the radiolabeling yield. The aim of this study was to evaluate the coordination yield of yttrium- and lutetium-DOTATATE complexes when the reaction is performed in the presence of varying amounts of competing cationic impurities. In the first set of experiments, the preparation of the samples was performed by using natural yttrium and lutetium (20.4 nmol). The molar ratio between DOTATATE and these metals was 1 to 1. Metal competitors (Pb(2+), Zn(2+), Cu(2+), Fe(3+), Al(3+), Ni(2+), Co(2+), Cr(3+)) were added separately to obtain samples with varying molar ratio with respect to yttrium or lutetium (0.1, 0.5, 1, 2 and 10). The final solutions were analyzed through ultra high-performance liquid chromatography with an UV detector. In the second set of experiments, an amount of (90)Y or (177)Lu chloride (6 MBq corresponding to 3.3 and 45 pmol, respectively) was added to the samples, and a radio-thin layer chromatography analysis was carried out. The coordination of Y(3+) and Lu(3+) was dramatically influenced by low levels of Zn(2+), Cu(2+) and Co(2+). Pb(2+) and Ni(2+) were also shown to be strong competitors at higher concentrations. Fe(3+) was expected to be a strong competitor, but the effect on the incorporation was only partly dependent on its concentration. Al(3+) and Cr(3+) did not compete with Y(3+) and Lu(3+) in the formation of DOTATATE complexes. Copyright © 2012 Elsevier Inc. All rights reserved.

  7. On the use of X-ray absorption spectroscopy to elucidate the structure of lutetium adenosine mono- and triphosphate complexes.

    PubMed

    Mostapha, S; Berthon, C; Fontaine-Vive, F; Gaysinski, M; Guérin, L; Guillaumont, D; Massi, L; Monfardini, I; Solari, P L; Thomas, O P; Charbonnel, M C; Den Auwer, C

    2014-02-01

    Although the physiological impact of the actinide elements as nuclear toxicants has been widely investigated for half a century, a description of their interactions with biological molecules remains limited. It is however of primary importance to better assess the determinants of actinide speciation in cells and more generally in living organisms to unravel the molecular processes underlying actinide transport and deposition in tissues. The biological pathways of this family of elements in case of accidental contamination or chronic natural exposure (in the case of uranium rich soils for instance) are therefore a crucial issue of public health and of societal impact. Because of the high chemical affinity of those actinide elements for phosphate groups and the ubiquity of such chemical functions in biochemistry, phosphate derivatives are considered as probable targets of these cations. Among them, nucleotides and in particular adenosine mono- (AMP) and triphosphate (ATP) nucleotides occur in more chemical reactions than any other compounds on the earth's surface, except water, and are therefore critical target molecules. In the present study, we are interested in trans-plutonium actinide elements, in particular americium and curium that are more rarely considered in environmental and bioaccumulation studies than early actinides like uranium, neptunium and plutonium. A first step in this strategy is to work with chemical analogues like lanthanides that are not radioactive and therefore allow extended physical chemical characterization to be conducted that are difficult to perform with radioactive materials. We describe herein the interaction of lutetium(III) with adenosine AMP and ATP. With AMP and ATP, insoluble amorphous compounds have been obtained with molar ratios of 1:2 and 1:1, respectively. With an excess of ATP, with 1:2 molar ratio, a soluble complex has been obtained. A combination of spectroscopic techniques (IR, NMR, ESI-MS, EXAFS) together with quantum

  8. 33 CFR 156.111 - Incorporation by reference.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., England. Ship to Ship Transfer Guide (Petroleum), Second Edition, 1988—156.330. International Chamber of Shipping 12 Carthusian Street, London EC1M 6EB, England. Guide to Helicopter/Ship Operations, Third Edition...

  9. 19 CFR 122.156 - Release of passengers.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... TREASURY AIR COMMERCE REGULATIONS Flights to and From Cuba § 122.156 Release of passengers. No passengers arriving from Cuba by aircraft will be released by Customs, nor will the aircraft be cleared or permitted...

  10. 19 CFR 122.156 - Release of passengers.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... TREASURY AIR COMMERCE REGULATIONS Flights to and From Cuba § 122.156 Release of passengers. No passengers arriving from Cuba by aircraft will be released by Customs, nor will the aircraft be cleared or permitted...

  11. 19 CFR 122.156 - Release of passengers.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... TREASURY AIR COMMERCE REGULATIONS Flights to and From Cuba § 122.156 Release of passengers. No passengers arriving from Cuba by aircraft will be released by Customs, nor will the aircraft be cleared or permitted...

  12. 19 CFR 122.156 - Release of passengers.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... TREASURY AIR COMMERCE REGULATIONS Flights to and From Cuba § 122.156 Release of passengers. No passengers arriving from Cuba by aircraft will be released by Customs, nor will the aircraft be cleared or permitted...

  13. 19 CFR 122.156 - Release of passengers.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... TREASURY AIR COMMERCE REGULATIONS Flights to and From Cuba § 122.156 Release of passengers. No passengers arriving from Cuba by aircraft will be released by Customs, nor will the aircraft be cleared or permitted...

  14. 49. Overall view of building 156, Warhead Building on far ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    49. Overall view of building 156, Warhead Building on far left, and building 160, acid fueling station on far right, looking west - Nike Missile Battery MS-40, County Road No. 260, Farmington, Dakota County, MN

  15. 48. Overall view of building 156, Warhead Building on far ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    48. Overall view of building 156, Warhead Building on far right, and building 160, acid fueling station on far left, looking east - Nike Missile Battery MS-40, County Road No. 260, Farmington, Dakota County, MN

  16. 47. Overall view of building 156, Warhead Building on far ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    47. Overall view of building 156, Warhead Building on far right, and building 160, acid fueling station on far left, looking northeast - Nike Missile Battery MS-40, County Road No. 260, Farmington, Dakota County, MN

  17. 51. Overall view of building 156, Warhead Building on far ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    51. Overall view of building 156, Warhead Building on far left, acid fueling station and standby generator building on far right, looking northwest - Nike Missile Battery MS-40, County Road No. 260, Farmington, Dakota County, MN

  18. 30 CFR 15.6 - Issuance of approval.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... § 15.6 Issuance of approval. (a) MSHA will issue an approval or a notice of the reasons for denying... advertise or otherwise represent an explosive or sheathed explosive unit as approved until MSHA has...

  19. 46 CFR 160.156-5 - Incorporation by reference.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Alloy-Coated (Galvannealed) by the Hot-Dip Process, (approved July 15, 2008), IBR approved for §§ 160... Tanks, Fourth Edition (September 26, 1996), IBR approved for § 160.156-7 (“UL 1185”). ...

  20. View from southwest of #156 and #157 with covered breezeways ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View from southwest of #156 and #157 with covered breezeways - National Home for Disabled Volunteer Soldiers, Pacific Branch, Mental Health Buildings, 11301 Wilshire Boulevard, West Los Angeles, Los Angeles County, CA

  1. 40 CFR 417.156 - Pretreatment standards for new sources.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... GUIDELINES AND STANDARDS SOAP AND DETERGENT MANUFACTURING POINT SOURCE CATEGORY Manufacture of Spray Dried Detergents Subcategory § 417.156 Pretreatment standards for new sources. Any new source subject to this...

  2. 40 CFR 417.156 - Pretreatment standards for new sources.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... GUIDELINES AND STANDARDS SOAP AND DETERGENT MANUFACTURING POINT SOURCE CATEGORY Manufacture of Spray Dried Detergents Subcategory § 417.156 Pretreatment standards for new sources. Any new source subject to this...

  3. 40 CFR 417.156 - Pretreatment standards for new sources.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... GUIDELINES AND STANDARDS SOAP AND DETERGENT MANUFACTURING POINT SOURCE CATEGORY Manufacture of Spray Dried Detergents Subcategory § 417.156 Pretreatment standards for new sources. Any new source subject to this...

  4. 40 CFR 417.156 - Pretreatment standards for new sources.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... GUIDELINES AND STANDARDS SOAP AND DETERGENT MANUFACTURING POINT SOURCE CATEGORY Manufacture of Spray Dried Detergents Subcategory § 417.156 Pretreatment standards for new sources. Any new source subject to this...

  5. 156. Detail of lightning arrester on hillside above powerhouse; looking ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    156. Detail of lightning arrester on hillside above powerhouse; looking west. Photo by Jet Lowe, HAER, 1989. - Puget Sound Power & Light Company, White River Hydroelectric Project, 600 North River Avenue, Dieringer, Pierce County, WA

  6. 50. Overall view of building 156, Warhead Building on far ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    50. Overall view of building 156, Warhead Building on far left, and building 157, sentry control box at entry to launch pad at far right, looking east - Nike Missile Battery MS-40, County Road No. 260, Farmington, Dakota County, MN

  7. 40 CFR 417.156 - Pretreatment standards for new sources.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... GUIDELINES AND STANDARDS SOAP AND DETERGENT MANUFACTURING POINT SOURCE CATEGORY Manufacture of Spray Dried Detergents Subcategory § 417.156 Pretreatment standards for new sources. Any new source subject to...

  8. 33 CFR 156.300 - Designated lightering zones.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Requirements for the Gulf of Mexico § 156.300 Designated lightering zones. The following lightering zones are designated in the Gulf of Mexico and are more than 60 miles from the baseline from which the territorial sea...

  9. 42 CFR 460.156 - Other enrollment procedures.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... (CONTINUED) PROGRAMS OF ALL-INCLUSIVE CARE FOR THE ELDERLY (PACE) PROGRAMS OF ALL-INCLUSIVE CARE FOR THE ELDERLY (PACE) Participant Enrollment and Disenrollment § 460.156 Other enrollment procedures. (a) Items...

  10. 42 CFR 460.156 - Other enrollment procedures.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... (CONTINUED) PROGRAMS OF ALL-INCLUSIVE CARE FOR THE ELDERLY (PACE) PROGRAMS OF ALL-INCLUSIVE CARE FOR THE ELDERLY (PACE) Participant Enrollment and Disenrollment § 460.156 Other enrollment procedures. (a) Items...

  11. 42 CFR 460.156 - Other enrollment procedures.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... (CONTINUED) PROGRAMS OF ALL-INCLUSIVE CARE FOR THE ELDERLY (PACE) PROGRAMS OF ALL-INCLUSIVE CARE FOR THE ELDERLY (PACE) Participant Enrollment and Disenrollment § 460.156 Other enrollment procedures. (a) Items...

  12. 42 CFR 460.156 - Other enrollment procedures.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... (CONTINUED) PROGRAMS OF ALL-INCLUSIVE CARE FOR THE ELDERLY (PACE) PROGRAMS OF ALL-INCLUSIVE CARE FOR THE ELDERLY (PACE) Participant Enrollment and Disenrollment § 460.156 Other enrollment procedures. (a) Items...

  13. 44 CFR 15.6 - Compliance with signs and directions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ..., DEPARTMENT OF HOMELAND SECURITY GENERAL CONDUCT AT THE MT. WEATHER EMERGENCY ASSISTANCE CENTER AND AT THE NATIONAL EMERGENCY TRAINING CENTER § 15.6 Compliance with signs and directions. Persons at Mt. Weather and...

  14. 44 CFR 15.6 - Compliance with signs and directions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ..., DEPARTMENT OF HOMELAND SECURITY GENERAL CONDUCT AT THE MT. WEATHER EMERGENCY ASSISTANCE CENTER AND AT THE NATIONAL EMERGENCY TRAINING CENTER § 15.6 Compliance with signs and directions. Persons at Mt. Weather and...

  15. 44 CFR 15.6 - Compliance with signs and directions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ..., DEPARTMENT OF HOMELAND SECURITY GENERAL CONDUCT AT THE MT. WEATHER EMERGENCY ASSISTANCE CENTER AND AT THE NATIONAL EMERGENCY TRAINING CENTER § 15.6 Compliance with signs and directions. Persons at Mt. Weather and...

  16. 44 CFR 15.6 - Compliance with signs and directions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ..., DEPARTMENT OF HOMELAND SECURITY GENERAL CONDUCT AT THE MT. WEATHER EMERGENCY ASSISTANCE CENTER AND AT THE NATIONAL EMERGENCY TRAINING CENTER § 15.6 Compliance with signs and directions. Persons at Mt. Weather and...

  17. 50 CFR 216.156 - Applications for Letters of Authorization.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Nicolas Island, CA § 216.156 Applications for Letters of Authorization. (a) To incidentally take marine... Authorization must include the following: (1) Name of the U.S. citizen requesting the authorization, (2) A...

  18. In situ chemichromic studies of interactions between a lutetium bis-octaalkyl-substituted phthalocyanine and selected biological cofactors

    PubMed Central

    Pal, C.; Cammidge, A. N.; Cook, M. J.; Sosa-Sanchez, J. L.; Sharma, A. K.; Ray, A. K.

    2012-01-01

    Spin-coated films, approximately 100 nm thick, of a newly synthesized bis[octakis(octyl)phthalocyaninato] lutetium(III) complex on ultrasonically cleaned glass substrates exhibit pronounced chemichromic behaviour with potential application in healthcare. In situ kinetic optical absorption spectroscopic measurements show that the phthalocyanine Q-band is red shifted by 60 nm upon oxidation arising from exposure to bromine vapour. Recovery to the original state is achieved by the treatment of the oxidized films with nicotinamide adenine dinucleotide and l-ascorbic acid (vitamin C) in an aqueous solution containing 1.5 M lithium perchlorate. The neutralization process is found to be governed by first-order kinetics. The linear increase of the reduction rate with increasing concentration of cofactors provides a basis for calibration of analyte concentrations ranging from 3.5 mM down to 0.03 mM. PMID:21676969

  19. Nonlinear optical properties of lutetium and dysprosium bisphthalocyanines at 1550 nm with femto- and nanosecond pulse excitation

    NASA Astrophysics Data System (ADS)

    Plekhanov, A. I.; Basova, T. V.; Parkhomenko, R. G.; Gürek, A. G.

    2017-02-01

    In this work, the nonlinear optical properties of unsubstituted lutetium (LuPc2) and dysprosium (DyPc2) bisphthalocyanines as well as octasubstituted Lu(PcR8)2 derivative with R=-S(C6H13) were studied at a wavelength of 1550 nm with 10 ns and 300 fs pulses. Based on Z-scan measurements the nonlinear absorption and refraction coefficient as well as the nature of nonlinear optical properties were analyzed for these materials. Open aperture Z-scan indicates strong two-photon absorption in all three bisphthalocyanines in nano- and femtosecond regimes. With good nonlinear optical coefficients, bisphthalocyanines of rare earth elements are expected to be promising materials for the creation of optical limiters.

  20. Raman scattering in organic semiconductors based on erbium biphthalocyanine molecules and chlorine-containing europium-lutetium triphthalocyanine molecules

    SciTech Connect

    Belogorokhov, I. A.; Mamichev, D. A.; Dronov, M. A.; Pushkarev, V. E.; Tomilova, L. G.; Khokhlov, D. R.

    2010-08-15

    The Raman spectra of semiconductor structures based on erbium biphthalocyanine molecules and chlorine-substituted europium-lutetium triphthalocyanine molecules are studied on excitation with Ar{sup +} laser radiation at the wavelength 514 nm. The data on the spectral position of Raman intensity peaks related to vibronic states of the basic molecular groups forming the semiconductor are obtained. Raman lines irrelevant to the known vibronic states of the basic phthalocyanine molecular groups are observed in the ranges 100-500 and 500-900 cm{sup -1}. It is shown that, in the spectra of triphthalocyanine, some lines are structurally complex and shifted with respect to the characteristic lines of molecular groups by several inverse centimeters.

  1. In situ chemichromic studies of interactions between a lutetium bis-octaalkyl-substituted phthalocyanine and selected biological cofactors.

    PubMed

    Pal, C; Cammidge, A N; Cook, M J; Sosa-Sanchez, J L; Sharma, A K; Ray, A K

    2012-01-07

    Spin-coated films, approximately 100 nm thick, of a newly synthesized bis[octakis(octyl)phthalocyaninato] lutetium(III) complex on ultrasonically cleaned glass substrates exhibit pronounced chemichromic behaviour with potential application in healthcare. In situ kinetic optical absorption spectroscopic measurements show that the phthalocyanine Q-band is red shifted by 60 nm upon oxidation arising from exposure to bromine vapour. Recovery to the original state is achieved by the treatment of the oxidized films with nicotinamide adenine dinucleotide and l-ascorbic acid (vitamin C) in an aqueous solution containing 1.5 M lithium perchlorate. The neutralization process is found to be governed by first-order kinetics. The linear increase of the reduction rate with increasing concentration of cofactors provides a basis for calibration of analyte concentrations ranging from 3.5 mM down to 0.03 mM.

  2. Low-damping sub-10-nm thin films of lutetium iron garnet grown by molecular-beam epitaxy

    NASA Astrophysics Data System (ADS)

    Jermain, C. L.; Paik, H.; Aradhya, S. V.; Buhrman, R. A.; Schlom, D. G.; Ralph, D. C.

    2016-11-01

    We analyze the structural and magnetic characteristics of (111)-oriented lutetium iron garnet (Lu3Fe5O12) films grown by molecular-beam epitaxy, for films as thin as 2.8 nm. Thickness-dependent measurements of the in- and out-of-plane ferromagnetic resonance allow us to quantify the effects of two-magnon scattering, along with the surface anisotropy and the saturation magnetization. We achieve effective damping coefficients of 11.1 (9 )×10-4 for 5.3 nm films and 32 (3 )×10-4 for 2.8 nm films, among the lowest values reported to date for any insulating ferrimagnetic sample of comparable thickness.

  3. Sugar promotes vegetative phase change in Arabidopsis thaliana by repressing the expression of MIR156A and MIR156C.

    PubMed

    Yang, Li; Xu, Mingli; Koo, Yeonjong; He, Jia; Poethig, R Scott

    2013-03-26

    Nutrients shape the growth, maturation, and aging of plants and animals. In plants, the juvenile to adult transition (vegetative phase change) is initiated by a decrease in miR156. In Arabidopsis, we found that exogenous sugar decreased the abundance of miR156, whereas reduced photosynthesis increased the level of this miRNA. This effect was correlated with a change in the timing of vegetative phase change, and was primarily attributable to a change in the expression of two genes, MIR156A and MIR156C, which were found to play dominant roles in this transition. The glucose-induced repression of miR156 was dependent on the signaling activity of HEXOKINASE1. We also show that the defoliation-induced increase in miR156 levels can be suppressed by exogenous glucose. These results provide a molecular link between nutrient availability and developmental timing in plants, and suggest that sugar is a component of the leaf signal that mediates vegetative phase change. DOI:http://dx.doi.org/10.7554/eLife.00260.001.

  4. Updated results of a phase I trial of motexafin lutetium-mediated interstitial photodynamic therapy in patients with locally recurrent prostate cancer.

    PubMed

    Verigos, Kosmas; Stripp, Diana C Hsiung; Mick, Rosemarie; Zhu, Timothy C; Whittington, Richard; Smith, Debbie; Dimofte, Andreea; Finlay, Jarod; Busch, Theresa M; Tochner, Zelig A; Malkowicz, S; Glatstein, Eli; Hahn, Stephen M

    2006-01-01

    Locally recurrent prostate cancer after treatment with radiation therapy is a clinical problem with few acceptable treatments. One potential treatment, photodynamic therapy (PDT), is a modality that uses laser light, drug photosensitizer, and oxygen to kill tumor cells through direct cellular cytotoxicity and/or through destruction of tumor vasculature. A Phase I trial of interstitial PDT with the photosensitizer Motexafin lutetium was initiated in men with locally recurrent prostate cancer. In this ongoing trial, the primary objective is to determine the maximally tolerated dose of Motexafin lutetium-mediated PDT. Other objectives include evaluation of Motexafin lutetium uptake from prostate tissue using a spectrofluorometric assay and evaluation of optical properties in the human prostate. Fifteen men with biopsy-proven locally recurrent prostate cancer and no evidence of distant metastatic disease have been enrolled and 14 have been treated. Treatment plans were developed using transrectal ultrasound images. The PDT dose was escalated by increasing the Motexafin lutetium dose, increasing the 732 ran light dose, and decreasing the drug-light interval. Motexafin lutetium doses ranged from 0.5 to 2 mg/kg administered IV 24, 6, or 3 hr prior to 732 ran light delivery. The light dose, measured in real time with in situ spherical detectors was 25-100 J/cm2. Light was delivered via optical fibers inserted through a transperineal brachytherapy template in the operating room. Optical property measurements were made before and after light therapy. Prostate biopsies were obtained before and after light delivery for spectrofluorometric measurements of photosensitizer uptake. Fourteen patients have completed protocol treatment on eight dose levels without dose-limiting toxicity. Grade I genitourinary symptoms that are PDT related have been observed. One patient had Grade II urinary urgency that was urinary catheter related. No rectal or other gastrointestinal PDT-related tox

  5. Piano-stool lutetium amido and imido compounds supported by a constrained bis(oxazoline)cyclopentadienyl ligand

    SciTech Connect

    Lampland, Nicole L.; Zhu, Jing; Hovey, Megan; Jana, Barun; Ellern, Arkady; Sadow, Aaron D.

    2015-06-25

    {BoMCptet}Lu(CH2Ph)2 (1; BoMCptet = MeC(OxMe2 2C5Me4; OxMe2 = 4,4-dimethyl-2-oxazoline) was prepared in 95% yield from the reaction of BoMCptetH and Lu(CH2Ph)3THF3. Compound 1 reacts with 1 or 2 equiv of H2NCH2R (R = C6H5, 1-C10H7) to give the corresponding imido complexes [{BoMCptet}LuNCH2R]2 (R = C6H5 (2a), 1-C10H7 (2b)) or amido complexes {BoMCptet}Lu(NHCH2R)2 (R = C6H5 (3a), 1-C10H7 (3b)). When isolated, the imido species are insoluble in nonprotic organic solvents. Crystallographic characterization reveals dimeric [{BoMCptet}LuNCH2(1-C10H7)]2 in the solid state. The reaction of 1 and NH3B(C6F5)3 affords crystallographically characterized {BoMCptet}Lu{NHB(C6F5)2}C6F5. This species is proposed to form via a transient lutetium imido, which undergoes C6F5 migration to the lutetium center.

  6. 46 CFR 160.156-17 - Marking and labeling.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...: SPECIFICATIONS AND APPROVAL LIFESAVING EQUIPMENT Rescue Boats and Fast Rescue Boats (SOLAS) § 160.156-17 Marking and labeling. (a) Each rescue boat must be marked with a plate or label permanently affixed to the hull in a conspicuous place readily accessible for inspection and sufficiently durable to withstand...

  7. 46 CFR 160.156-17 - Marking and labeling.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...: SPECIFICATIONS AND APPROVAL LIFESAVING EQUIPMENT Rescue Boats and Fast Rescue Boats (SOLAS) § 160.156-17 Marking and labeling. (a) Each rescue boat must be marked with a plate or label permanently affixed to the hull in a conspicuous place readily accessible for inspection and sufficiently durable to withstand...

  8. 156. Photocopy of written record (taken from Twin Falls Canal ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    156. Photocopy of written record (taken from Twin Falls Canal Company, Low Line Book #1, pp.2,3). LOW LINE CONTRACTORS AND BORROW RECORD. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  9. 156. Frank Deras Jr., Photographer December 1997 DETAIL VIEW OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    156. Frank Deras Jr., Photographer December 1997 DETAIL VIEW OF STRAND SHOE AND EYE BAR AT SAN FRANCISCO ANCHORAGE (HUMAN SCALE: TERRY COSTA, CALTRANS EMPLOYEE), FACING SOUTHEAST. - San Francisco Oakland Bay Bridge, Spanning San Francisco Bay, San Francisco, San Francisco County, CA

  10. 17 CFR 230.156 - Investment company sales literature.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 2 2013-04-01 2013-04-01 false Investment company sales... GENERAL RULES AND REGULATIONS, SECURITIES ACT OF 1933 General § 230.156 Investment company sales... company. Under these provisions, sales literature is materially misleading if it: (1) Contains an...

  11. 17 CFR 230.156 - Investment company sales literature.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 3 2014-04-01 2014-04-01 false Investment company sales... GENERAL RULES AND REGULATIONS, SECURITIES ACT OF 1933 General § 230.156 Investment company sales... company. Under these provisions, sales literature is materially misleading if it: (1) Contains an...

  12. 17 CFR 230.156 - Investment company sales literature.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 2 2012-04-01 2012-04-01 false Investment company sales... GENERAL RULES AND REGULATIONS, SECURITIES ACT OF 1933 General § 230.156 Investment company sales... company. Under these provisions, sales literature is materially misleading if it: (1) Contains an...

  13. 17 CFR 230.156 - Investment company sales literature.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Investment company sales... GENERAL RULES AND REGULATIONS, SECURITIES ACT OF 1933 General § 230.156 Investment company sales... company. Under these provisions, sales literature is materially misleading if it: (1) Contains an...

  14. 17 CFR 230.156 - Investment company sales literature.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 2 2011-04-01 2011-04-01 false Investment company sales... GENERAL RULES AND REGULATIONS, SECURITIES ACT OF 1933 General § 230.156 Investment company sales... company. Under these provisions, sales literature is materially misleading if it: (1) Contains an...

  15. 33 CFR 156.160 - Supervision by person in charge.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... (CONTINUED) POLLUTION OIL AND HAZARDOUS MATERIAL TRANSFER OPERATIONS Oil and Hazardous Material Transfer... in charge, required by § 156.120(s), supervises that procedure. (b) No person may start the flow of oil or hazardous material to or from a vessel unless instructed to do so by either person in charge...

  16. 33 CFR 156.160 - Supervision by person in charge.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... (CONTINUED) POLLUTION OIL AND HAZARDOUS MATERIAL TRANSFER OPERATIONS Oil and Hazardous Material Transfer... in charge, required by § 156.120(s), supervises that procedure. (b) No person may start the flow of oil or hazardous material to or from a vessel unless instructed to do so by either person in charge...

  17. 33 CFR 156.160 - Supervision by person in charge.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... (CONTINUED) POLLUTION OIL AND HAZARDOUS MATERIAL TRANSFER OPERATIONS Oil and Hazardous Material Transfer... in charge, required by § 156.120(s), supervises that procedure. (b) No person may start the flow of oil or hazardous material to or from a vessel unless instructed to do so by either person in charge...

  18. 33 CFR 156.160 - Supervision by person in charge.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... (CONTINUED) POLLUTION OIL AND HAZARDOUS MATERIAL TRANSFER OPERATIONS Oil and Hazardous Material Transfer... in charge, required by § 156.120(s), supervises that procedure. (b) No person may start the flow of oil or hazardous material to or from a vessel unless instructed to do so by either person in charge...

  19. 14 CFR 135.156 - Flight data recorders: filtered data.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Flight data recorders: filtered data. 135... Aircraft and Equipment § 135.156 Flight data recorders: filtered data. (a) A flight data signal is filtered... original sensor signal value can be reconstructed from the recorded data. This demonstration requires that...

  20. 14 CFR 135.156 - Flight data recorders: filtered data.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Flight data recorders: filtered data. 135... Aircraft and Equipment § 135.156 Flight data recorders: filtered data. (a) A flight data signal is filtered... original sensor signal value can be reconstructed from the recorded data. This demonstration requires that...

  1. 14 CFR 135.156 - Flight data recorders: filtered data.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Flight data recorders: filtered data. 135... Aircraft and Equipment § 135.156 Flight data recorders: filtered data. (a) A flight data signal is filtered... original sensor signal value can be reconstructed from the recorded data. This demonstration requires that...

  2. 14 CFR 135.156 - Flight data recorders: filtered data.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Flight data recorders: filtered data. 135... Aircraft and Equipment § 135.156 Flight data recorders: filtered data. (a) A flight data signal is filtered... original sensor signal value can be reconstructed from the recorded data. This demonstration requires that...

  3. 17 CFR 156.3 - Contract market program for enforcement.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 1 2011-04-01 2011-04-01 false Contract market program for... BROKER ASSOCIATIONS § 156.3 Contract market program for enforcement. A contract market must, as part of... abuse and to secure compliance with all other contract market bylaws, rules, regulations and resolutions...

  4. 17 CFR 156.3 - Contract market program for enforcement.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Contract market program for... BROKER ASSOCIATIONS § 156.3 Contract market program for enforcement. A contract market must, as part of... abuse and to secure compliance with all other contract market bylaws, rules, regulations and resolutions...

  5. 40 CFR 156.70 - Precautionary statements for human hazards.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 24 2011-07-01 2011-07-01 false Precautionary statements for human...) PESTICIDE PROGRAMS LABELING REQUIREMENTS FOR PESTICIDES AND DEVICES Human Hazard and Precautionary Statements § 156.70 Precautionary statements for human hazards. (a) Requirement. Human hazard...

  6. 40 CFR 156.70 - Precautionary statements for human hazards.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Precautionary statements for human...) PESTICIDE PROGRAMS LABELING REQUIREMENTS FOR PESTICIDES AND DEVICES Human Hazard and Precautionary Statements § 156.70 Precautionary statements for human hazards. (a) Requirement. Human hazard...

  7. 18 CFR 156.2 - Purpose and intent of rules.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... which the natural gas company would be required to make in connection with the rendition of the service... COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER NATURAL GAS ACT APPLICATIONS FOR ORDERS UNDER SECTION 7(a) OF THE NATURAL GAS ACT § 156.2 Purpose and intent of rules. (a) Applications filed pursuant to...

  8. 18 CFR 156.1 - Who may apply.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... OF ENERGY REGULATIONS UNDER NATURAL GAS ACT APPLICATIONS FOR ORDERS UNDER SECTION 7(a) OF THE NATURAL GAS ACT § 156.1 Who may apply. Any person or municipality as defined in section 2 of the Natural Gas Act engaged or legally authorized to engage in the local distribution of natural or artificial gas...

  9. 45 CFR 156.80 - Single risk pool.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Provisions § 156.80 Single risk pool. (a) Individual market. A health insurance issuer must consider the... a single risk pool. (b) Small group market. A health insurance issuer must consider the claims... health insurance issuer must establish an index rate that is effective January 1 of each calendar year...

  10. Mass properties report on 156-inch diameter SRM

    NASA Technical Reports Server (NTRS)

    1972-01-01

    Mass properties data for 156-in.-dia SRM booster with two segments are presented. The SRM baseline booster has a fixed 15 degrees canted nozzle and no thrust neutralization system. Summary mass properties data for alternative booster configurations are included.

  11. 17 CFR 38.156 - Automated trade surveillance system.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 1 2014-04-01 2014-04-01 false Automated trade surveillance... DESIGNATED CONTRACT MARKETS Compliance With Rules § 38.156 Automated trade surveillance system. A designated contract market must maintain an automated trade surveillance system capable of detecting and investigating...

  12. 17 CFR 38.156 - Automated trade surveillance system.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 1 2013-04-01 2013-04-01 false Automated trade surveillance... DESIGNATED CONTRACT MARKETS Compliance With Rules § 38.156 Automated trade surveillance system. A designated contract market must maintain an automated trade surveillance system capable of detecting and investigating...

  13. 17 CFR 156.2 - Registration of broker association.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 1 2012-04-01 2012-04-01 false Registration of broker... BROKER ASSOCIATIONS § 156.2 Registration of broker association. (a) Registration required. It shall be...) require registration of each relationship defined by its rules as a broker association no later than...

  14. 33 CFR 156.111 - Incorporation by reference.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... follows: Oil Companies International Marine Forum (OCIMF) 15th Floor, 96 Victoria Street, London SW1E 5JW, England. Ship to Ship Transfer Guide (Petroleum), Second Edition, 1988—156.330. International Chamber of... (CONTINUED) POLLUTION OIL AND HAZARDOUS MATERIAL TRANSFER OPERATIONS Oil and Hazardous Material...

  15. 33 CFR 156.111 - Incorporation by reference.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... follows: Oil Companies International Marine Forum (OCIMF) 15th Floor, 96 Victoria Street, London SW1E 5JW, England. Ship to Ship Transfer Guide (Petroleum), Second Edition, 1988—156.330. International Chamber of... (CONTINUED) POLLUTION OIL AND HAZARDOUS MATERIAL TRANSFER OPERATIONS Oil and Hazardous Material...

  16. 33 CFR 156.111 - Incorporation by reference.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... follows: Oil Companies International Marine Forum (OCIMF) 15th Floor, 96 Victoria Street, London SW1E 5JW, England. Ship to Ship Transfer Guide (Petroleum), Second Edition, 1988—156.330. International Chamber of... (CONTINUED) POLLUTION OIL AND HAZARDOUS MATERIAL TRANSFER OPERATIONS Oil and Hazardous Material...

  17. 33 CFR 156.111 - Incorporation by reference.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... follows: Oil Companies International Marine Forum (OCIMF) 15th Floor, 96 Victoria Street, London SW1E 5JW, England. Ship to Ship Transfer Guide (Petroleum), Second Edition, 1988—156.330. International Chamber of... (CONTINUED) POLLUTION OIL AND HAZARDOUS MATERIAL TRANSFER OPERATIONS Oil and Hazardous Material...

  18. 45 CFR 156.115 - Provision of EHB.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... behavioral health treatment services, required under § 156.110(a)(5) of this subpart, comply with the... population; and (iv) Determined regardless of cost-sharing. (c) A health plan does not fail to provide EHB... of a plan offering EHB may not include routine non-pediatric dental services, routine...

  19. 45 CFR 156.115 - Provision of EHB.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... behavioral health treatment services, required under § 156.110(a)(5) of this subpart, comply with the... population; and (iv) Determined regardless of cost-sharing. (c) A health plan does not fail to provide EHB... of a plan offering EHB may not include routine non-pediatric dental services, routine...

  20. 40 CFR 156.68 - First aid statement.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 24 2011-07-01 2011-07-01 false First aid statement. 156.68 Section... aid statement. (a) Product as sold and distributed. Each product must bear a first aid statement if... with water prior to use, the label may also include a statement describing how the first aid...

  1. 40 CFR 156.68 - First aid statement.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 25 2013-07-01 2013-07-01 false First aid statement. 156.68 Section... aid statement. (a) Product as sold and distributed. Each product must bear a first aid statement if... with water prior to use, the label may also include a statement describing how the first aid...

  2. 40 CFR 156.68 - First aid statement.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 24 2014-07-01 2014-07-01 false First aid statement. 156.68 Section... aid statement. (a) Product as sold and distributed. Each product must bear a first aid statement if... with water prior to use, the label may also include a statement describing how the first aid...

  3. 40 CFR 156.68 - First aid statement.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 25 2012-07-01 2012-07-01 false First aid statement. 156.68 Section... aid statement. (a) Product as sold and distributed. Each product must bear a first aid statement if... with water prior to use, the label may also include a statement describing how the first aid...

  4. 40 CFR 156.68 - First aid statement.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false First aid statement. 156.68 Section... aid statement. (a) Product as sold and distributed. Each product must bear a first aid statement if... with water prior to use, the label may also include a statement describing how the first aid...

  5. 24 CFR 983.156 - PHA acceptance of completed units.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 4 2013-04-01 2013-04-01 false PHA acceptance of completed units... Constructed Units § 983.156 PHA acceptance of completed units. (a) PHA determination of completion. When the PHA has received owner notice that the housing is completed: (1) The PHA must inspect to determine if...

  6. 24 CFR 983.156 - PHA acceptance of completed units.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 4 2011-04-01 2011-04-01 false PHA acceptance of completed units... Constructed Units § 983.156 PHA acceptance of completed units. (a) PHA determination of completion. When the PHA has received owner notice that the housing is completed: (1) The PHA must inspect to determine if...

  7. 24 CFR 983.156 - PHA acceptance of completed units.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 4 2014-04-01 2014-04-01 false PHA acceptance of completed units... Constructed Units § 983.156 PHA acceptance of completed units. (a) PHA determination of completion. When the PHA has received owner notice that the housing is completed: (1) The PHA must inspect to determine if...

  8. 24 CFR 983.156 - PHA acceptance of completed units.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 4 2012-04-01 2012-04-01 false PHA acceptance of completed units... Constructed Units § 983.156 PHA acceptance of completed units. (a) PHA determination of completion. When the PHA has received owner notice that the housing is completed: (1) The PHA must inspect to determine if...

  9. 24 CFR 983.156 - PHA acceptance of completed units.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false PHA acceptance of completed units... Constructed Units § 983.156 PHA acceptance of completed units. (a) PHA determination of completion. When the PHA has received owner notice that the housing is completed: (1) The PHA must inspect to determine if...

  10. 7 CFR 800.156 - Official inspection records.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... and Forms (general) § 800.156 Official inspection records. (a) Pan tickets. The record for each kind..., consist of one or more pan tickets as prescribed in the instructions. Activities that are performed as a series during the course of an inspection service may be recorded on one pan ticket or on separate...

  11. 7 CFR 800.156 - Official inspection records.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... and Forms (general) § 800.156 Official inspection records. (a) Pan tickets. The record for each kind..., consist of one or more pan tickets as prescribed in the instructions. Activities that are performed as a series during the course of an inspection service may be recorded on one pan ticket or on separate...

  12. 7 CFR 800.156 - Official inspection records.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... and Forms (general) § 800.156 Official inspection records. (a) Pan tickets. The record for each kind..., consist of one or more pan tickets as prescribed in the instructions. Activities that are performed as a series during the course of an inspection service may be recorded on one pan ticket or on separate...

  13. 156. Photographic copy of original construction drawing dated October 24, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    156. Photographic copy of original construction drawing dated October 24, 1930 (from Record Group 115, Denver Branch of the National Archives, Denver). OWYHEE DAM SPILLWAY; 60 X 12 RING GATE-CONTROL; SCALE FRAME AND SCALES. - Owyhee Dam, Across Owyhee River, Nyssa, Malheur County, OR

  14. 33 CFR 156.150 - Declaration of inspection.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... facility and the receiving vessel or facility; (2) The address of the facility or location of the transfer operation if not at a facility; (3) The date and time the transfer operation is started; (4) A list of the... the facility or vessel, as appropriate, meets § 156.120. (c) The declaration of inspection may be...

  15. 27 CFR 31.156 - Records of disposition.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2014-04-01 2014-04-01 false Records of disposition. 31... and Reports § 31.156 Records of disposition. (a) Information required. Every wholesale dealer in liquors must prepare a daily record of the physical disposition of each individual lot of distilled...

  16. 46 CFR 160.156-21 - Operation and maintenance instructions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ..., CONSTRUCTION, AND MATERIALS: SPECIFICATIONS AND APPROVAL LIFESAVING EQUIPMENT Rescue Boats and Fast Rescue Boats (SOLAS) § 160.156-21 Operation and maintenance instructions. (a) In order to comply with SOLAS, each rescue boat must have operation and maintenance instructions that— (1) Follows the general format...

  17. 18 CFR 156.3 - Applications; general requirements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Natural Gas Act; State under the laws of which applicant is incorporated, organized or authorized; and the... COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER NATURAL GAS ACT APPLICATIONS FOR ORDERS UNDER SECTION 7(a) OF THE NATURAL GAS ACT § 156.3 Applications; general requirements. (a) Applicable rules. The...

  18. 40 CFR 156.204 - Modification and waiver of requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...) PESTICIDE PROGRAMS LABELING REQUIREMENTS FOR PESTICIDES AND DEVICES Worker Protection Statements § 156.204... accordance with § 154.25(c) of this chapter that a pesticide should be placed in Special Review because the pesticide meets or exceeds the criteria for human health effects of § 154.7(a)(1)(2) or (6) of this...

  19. 40 CFR 156.204 - Modification and waiver of requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...) PESTICIDE PROGRAMS LABELING REQUIREMENTS FOR PESTICIDES AND DEVICES Worker Protection Statements § 156.204... accordance with § 154.25(c) of this chapter that a pesticide should be placed in Special Review because the pesticide meets or exceeds the criteria for human health effects of § 154.7(a)(1)(2) or (6) of this...

  20. 40 CFR 156.204 - Modification and waiver of requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) PESTICIDE PROGRAMS LABELING REQUIREMENTS FOR PESTICIDES AND DEVICES Worker Protection Statements § 156.204... accordance with § 154.25(c) of this chapter that a pesticide should be placed in Special Review because the pesticide meets or exceeds the criteria for human health effects of § 154.7(a)(1)(2) or (6) of this...

  1. 40 CFR 156.204 - Modification and waiver of requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...) PESTICIDE PROGRAMS LABELING REQUIREMENTS FOR PESTICIDES AND DEVICES Worker Protection Statements § 156.204... accordance with § 154.25(c) of this chapter that a pesticide should be placed in Special Review because the pesticide meets or exceeds the criteria for human health effects of § 154.7(a)(1)(2) or (6) of this...

  2. 40 CFR 156.204 - Modification and waiver of requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...) PESTICIDE PROGRAMS LABELING REQUIREMENTS FOR PESTICIDES AND DEVICES Worker Protection Statements § 156.204... accordance with § 154.25(c) of this chapter that a pesticide should be placed in Special Review because the pesticide meets or exceeds the criteria for human health effects of § 154.7(a)(1)(2) or (6) of this...

  3. 17 CFR 156.3 - Contract market program for enforcement.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 1 2012-04-01 2012-04-01 false Contract market program for... BROKER ASSOCIATIONS § 156.3 Contract market program for enforcement. A contract market must, as part of... abuse and to secure compliance with all other contract market bylaws, rules, regulations and...

  4. 17 CFR 156.3 - Contract market program for enforcement.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 2 2014-04-01 2014-04-01 false Contract market program for... (CONTINUED) BROKER ASSOCIATIONS § 156.3 Contract market program for enforcement. A contract market must, as... for potential abuse and to secure compliance with all other contract market bylaws, rules,...

  5. 17 CFR 156.3 - Contract market program for enforcement.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 1 2013-04-01 2013-04-01 false Contract market program for... BROKER ASSOCIATIONS § 156.3 Contract market program for enforcement. A contract market must, as part of... abuse and to secure compliance with all other contract market bylaws, rules, regulations and...

  6. 30 CFR 1206.156 - Transportation allowances-general.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... under § 1206.153 of this subpart. For purposes of this section, natural gas liquids will be considered... RESOURCES REVENUE PRODUCT VALUATION Federal Gas § 1206.156 Transportation allowances—general. (a) Where the value of gas has been determined pursuant to § 1206.152 or § 1206.153 of this subpart at a point...

  7. 30 CFR 1206.156 - Transportation allowances-general.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... under § 1206.153 of this subpart. For purposes of this section, natural gas liquids will be considered... RESOURCES REVENUE PRODUCT VALUATION Federal Gas § 1206.156 Transportation allowances—general. (a) Where the value of gas has been determined pursuant to § 1206.152 or § 1206.153 of this subpart at a point...

  8. 30 CFR 1206.156 - Transportation allowances-general.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... under § 1206.153 of this subpart. For purposes of this section, natural gas liquids will be considered... RESOURCES REVENUE PRODUCT VALUATION Federal Gas § 1206.156 Transportation allowances—general. (a) Where the value of gas has been determined pursuant to § 1206.152 or § 1206.153 of this subpart at a point...

  9. 45 CFR 156.235 - Essential community providers.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ....235 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS HEALTH INSURANCE ISSUER STANDARDS UNDER THE AFFORDABLE CARE ACT, INCLUDING STANDARDS RELATED TO EXCHANGES Qualified Health Plan Minimum Certification Standards § 156.235 Essential community providers. (a)...

  10. 45 CFR 156.230 - Network adequacy standards.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ....230 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS HEALTH INSURANCE ISSUER STANDARDS UNDER THE AFFORDABLE CARE ACT, INCLUDING STANDARDS RELATED TO EXCHANGES Qualified Health Plan Minimum Certification Standards § 156.230 Network adequacy standards. (a)...

  11. 45 CFR 156.220 - Transparency in coverage.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS HEALTH INSURANCE ISSUER STANDARDS UNDER THE AFFORDABLE CARE ACT, INCLUDING STANDARDS RELATED TO EXCHANGES Qualified Health Plan Minimum Certification Standards § 156.220 Transparency in coverage. (a) Required...

  12. Syntheses, Structure, Magnetism, and Optical Properties of Lutetium-based Interlanthanide Selenides

    SciTech Connect

    Booth, Corwin H; Jin, Geng Bang; Choi, Eun Sang; Guertin, Robert P.; Brooks, James S.; Booth, Corwin H.; Albrecht-Schmitt, Thomas E.

    2007-10-01

    Ln{sub 3}LuSe{sub 6} (Ln = La, Ce), {beta}-LnLuSe{sub 3} (Ln = Pr, Nd), and Ln{sub x}Lu{sub 4-x}Se{sub 6} (Ln = Sm, Gd; x = 1.82, 1.87) have been synthesized using a Sb{sub 2}Se{sub 3} flux at 1000 C. Ln{sub 3}LuSe{sub 6} (Ln = La, Ce) adopt the U{sub 3}ScS{sub 6}-type three-dimensional structure, which is constructed from two-dimensional {infinity}{sup 2} [Ln{sub 3}Se{sub 6}]{sup 3-} slabs with the gaps between these slabs filled by octahedrally coordinated Lu{sup 3+} ions. The series of {beta}-LnLuSe{sub 3} (Ln = Pr, Nd) are isotypic with UFeS{sub 3}. Their structures include layers formed from LuSe6 octahedra that are separated by eight-coordinate larger Ln{sup 3+} ions in bicapped trigonal prismatic environments. Sm{sub 1.82}Lu{sub 2.18}Se{sub 6} and Gd{sub 1.87}Lu{sub 2.13}Se{sub 6} crystallize in the disordered F-Ln{sub 2}S{sub 3} type structure with the eight-coordinate bicapped trigonal prismatic Ln(1) ions residing in the one-dimensional channels formed by three different double chains via edge and corner sharing. These double chains are constructed from Ln(2)Se{sub 7} monocapped trigonal prisms, Ln(3)Se{sub 6} octahedra, and Ln(4)S{sub 6} octahedra, respectively. The magnetic susceptibilities of {beta}-PrLuSe{sub 3} and {beta}-NdLuSe{sub 3} follow the Curie-Weiss law. Sm{sub 1.82}Lu{sub 2.18}Se{sub 6} shows van Vleck paramagnetism. Magnetic measurements show that Gd{sub 1.87}Lu{sub 2.13}Se{sub 6} undergoes an antiferromagnetic transition around 4 K. Ce{sub 3}LuSe{sub 6} exhibits ferromagnetic ordering below 5 K. The optical band gaps for La{sub 3}LuSe{sub 6}, Ce{sub 3}LuSe{sub 6}, {beta}- PrLuSe{sub 3}, {beta}-NdLuSe{sub 3}, Sm{sub 1.82}Lu{sub 2.18}Se{sub 6}, and Gd{sub 1.87}Lu{sub 2.13}Se{sub 6} are 1.26, 1.10, 1.56, 1.61, 1.51, and 1.56 eV, respectively.

  13. Photodynamic inactivation of pathogenic species Pseudomonas aeruginosa and Candida albicans with lutetium (III) acetate phthalocyanines and specific light irradiation.

    PubMed

    Mantareva, Vanya; Kussovski, Vesselin; Durmuş, Mahmut; Borisova, Ekaterina; Angelov, Ivan

    2016-11-01

    Photodynamic inactivation (PDI) is a light-associated therapeutic approach suitable for treatment of local acute infections. The method is based on specific light-activated compound which by specific irradiation and in the presence of molecular oxygen produced molecular singlet oxygen and other reactive oxygen species, all toxic for pathogenic microbial cells. The study presents photodynamic impact of two recently synthesized water-soluble cationic lutetium (III) acetate phthalocyanines (LuPc-5 and LuPc-6) towards two pathogenic strains, namely, the Gram-negative bacterium Pseudomonas aeruginosa and a fungus Candida albicans. The photodynamic effect was evaluated for the cells in suspensions and organized in 48-h developed biofilms. The relatively high levels of uptakes of LuPc-5 and LuPc-6 were determined for fungal cells compared to bacterial cells. The penetration depths and distribution of both LuPcs into microbial biofilms were investigated by means of confocal fluorescence microscopy. The photoinactivation efficiency was studied for a wide concentration range (0.85-30 μM) of LuPc-5 and LuPc-6 at a light dose of 50 J cm(-2) from red light-emitting diode (LED; 665 nm). The PDI study on microbial biofilms showed incomplete photoinactivation (<3 logs) for the used gentle drug-light protocol.

  14. Immobilization of lutetium bisphthalocyanine in nanostructured biomimetic sensors using the LbL technique for phenol detection.

    PubMed

    Fernandes, Edson Giuliani R; Brazaca, Lais C; Rodríguez-Mendez, Maria Luz; Saja, Jose Antonio de; Zucolotto, Valtencir

    2011-08-15

    This study describes the development of amperometric sensors based on poly(allylamine hydrochloride) (PAH) and lutetium bisphthalocyanine (LuPc(2)) films assembled using the Layer-by-Layer (LbL) technique. The films have been used as modified electrodes for catechol quantification. Electrochemical measurements have been employed to investigate the catalytic properties of the LuPc(2) immobilized in the LbL films. By chronoamperometry, the sensors present excellent sensitivity (20 nA μM(-1)) in a wide linear range (R(2)=0.994) up to 900 μM and limit of detection (s/n=3) of 37.5 × 10(-8)M for catechol. The sensors have good reproducibility and can be used at least for ten times. The work potential is +0.3 V vs. saturated calomel electrode (SCE). In voltammetry measurements, the calibration curve shows a good linearity (R(2)=0.992) in the range of catechol up to 500 μM with a sensitivity of 90 nA μM(-1) and LD of 8 μM. Copyright © 2011 Elsevier B.V. All rights reserved.

  15. Optimizing lutetium 177-anti-carbonic anhydrase IX radioimmunotherapy in an intraperitoneal clear cell renal cell carcinoma xenograft model.

    PubMed

    Muselaers, Constantijn H J; Oosterwijk, Egbert; Bos, Desirée L; Oyen, Wim J G; Mulders, Peter F A; Boerman, Otto C

    2014-01-01

    A new approach in the treatment of clear cell renal carcinoma (ccRCC) is radioimmunotherapy (RIT) using anti-carbonic anhydrase IX (CAIX) antibody G250. To investigate the potential of RIT with lutetium 177 (177Lu)-labeled G250, we conducted a protein dose escalation study and subsequently an RIT study in mice with intraperitoneally growing ccRCC lesions. Mice with intraperitoneal xenografts were injected with 1, 3, 10, 30, or 100 μg of G250 labeled with 10 MBq indium 111 (111In) to determine the optimal protein dose. The optimal protein dose determined with imaging and biodistribution studies was used in a subsequent RIT experiment in three groups of 10 mice with intraperitoneal SK-RC-52 tumors. One group received 13 MBq 177Lu-DOTA-G250, a control group received 13 MBq nonspecific 177Lu-MOPC21, and the second control group was not treated and received 20 MBq 111In-DOTA-G250. The optimal G250 protein dose to target ccRCC in this model was 10 μg G250. Treatment with 13 MBq 177Lu-DOTA-G250 was well tolerated and resulted in significantly prolonged median survival (139 days) compared to controls (49-53 days, p  =  .015), indicating that RIT has potential in this metastatic ccRCC model.

  16. Radiolabeling of substance P with lutetium-177 and biodistribution study in rat pancreatic tumor xenografted nude mice.

    PubMed

    De Araújo, E B; Pujatti, P B; Mengatti, J

    2010-05-10

    Pancreatic tumor (PT) is a neuroendocrine neoplasm that usually origin metastases in the respiratory and gastrointestinal tract. The presence of peptide receptors at the cell membrane of PT constitutes the basis of the clinical use of specific radiolabeled ligands for its diagnosis and targeted therapy. Substance P (SP), an 11-amino acid peptide which has an important role in modulating pain transmission trough neurokinin type 1 (NK1r) and 2 receptors (NK2r), may play a role in the pathogenesis of PT, because approximately 10% of these tumors overexpress NK1r. The aim of the present work was to produce a pure and stable SP analog (DOTA-SP) radiolabeled with lutetium-177 ((177)Lu), and to evaluate its in vivo target to AR42J pancreatic tumor cells in Nude mice, in other to verify if SP can be used in this pancreatic tumor detection and treatment. Substance P was successfully labeled with high yield (>99%) at optimized conditions and kept stable for more than 72 hours at 2-8 degrees C and 4 hours in human plasma. Biodistribution studies showed that SP excretion was mainly performed by renal pathway. In addition, (177)Lu-DOTA-SP showed higher uptake by tumor than normal pancreas, indicating the presence of NK receptors in AR42J pancreatic tumor.

  17. Spectroscopic refractive indices of monoclinic single crystal and ceramic Lutetium oxyorthosilicate (LSO) from 200 to 850 nm

    SciTech Connect

    Jellison Jr, Gerald Earle; Specht, Eliot D; Boatner, Lynn A; Singh, David J; Melcher, Charles L

    2012-01-01

    The four real values of the dielectric function tensor of the monoclinic crystal Lu2SiO5 or lutetium oxyorthosilicate (LSO) have been determined using generalized ellipsometry from 200 to 850 nm. The three principal values are fit to the Sellmeier model, and they indicate that the band gap of LSO is less than ~9 eV. The off-diagonal element 12 is non-zero over the entire spectrum, but it is very close to zero for wavelengths longer than ~400 nm, indicating that structurally monoclinic LSO is nearly optically orthorhombic in this wavelength region. The spectroscopic dielectric functions of three isotropic ceramic LSO samples are presented, which are consistent with the dielectric functions of single-crystal LSO when the effects of porosity are included. As a comparison, the dielectric functions are also determined using relativistic electronic structure and optical calculations based on the recently developed potential functional of Tran and Blaha (Phys. Rev. Lett. 102, 226401 (2009).)

  18. Fabrication and characterization of a 0.5-mm lutetium oxyorthosilicate detector array for high-resolution PET applications.

    PubMed

    Stickel, Jennifer R; Qi, Jinyi; Cherry, Simon R

    2007-01-01

    With the increasing use of in vivo imaging in mouse models of disease, there are many interesting applications that demand imaging of organs and tissues with submillimeter resolution. Though there are other contributing factors, the spatial resolution in small-animal PET is still largely determined by the detector pixel dimensions. In this work, a pair of lutetium oxyorthosilicate (LSO) arrays with 0.5-mm pixels was coupled to multichannel photomultiplier tubes and evaluated for use as high-resolution PET detectors. Flood histograms demonstrated that most crystals were clearly identifiable. Energy resolution varied from 22% to 38%. The coincidence timing resolution was 1.42-ns full width at half maximum (FWHM). The intrinsic spatial resolution was 0.68-mm FWHM as measured with a 30-gauge needle filled with (18)F. The improvement in spatial resolution in a tomographic setting is demonstrated using images of a line source phantom reconstructed with filtered backprojection and compared with images obtained from 2 dedicated small-animal PET scanners. Finally, a projection image of the mouse foot is shown to demonstrate the application of these 0.5-mm LSO detectors to a biologic task. A pair of highly pixelated LSO detections has been constructed and characterized for use as high-spatial-resolution PET detectors. It appears that small-animal PET systems capable of a FWHM spatial resolution of 600 microm or less are feasible and should be pursued.

  19. Spectroscopic information about a hypothetical tetrahedral configuration in Gd156

    NASA Astrophysics Data System (ADS)

    Doan, Q. T.; Vancraeyenest, A.; Stézowski, O.; Guinet, D.; Curien, D.; Dudek, J.; Lautesse, Ph.; Lehaut, G.; Redon, N.; Schmitt, Ch.; Duchêne, G.; Gall, B.; Molique, H.; Piot, J.; Greenlees, P. T.; Jakobsson, U.; Julin, R.; Juutinen, S.; Jones, P.; Ketelhut, S.; Nyman, M.; Peura, P.; Rahkila, P.; Góźdź, A.; Mazurek, K.; Schunck, N.; Zuber, K.; Bednarczyk, P.; Maj, A.; Astier, A.; Deloncle, I.; Verney, D.; de Angelis, G.; Gerl, J.

    2010-12-01

    A detailed γ-ray spectroscopy of the lowest two negative-parity bands in Gd156 has been performed in the framework of the TetraNuc collaboration. Relative γ-ray intensities of all transitions connecting these bands as well as the ones to the ground-state band are presented. Angular distribution analysis has been performed to determine the nature and the mixing ratio of one of the newly established transitions linking the two excited bands.

  20. 33 CFR 157.156 - COW operations: Meeting manual requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... CARRYING OIL IN BULK Crude Oil Washing (COW) System on Tank Vessels Cow Operations § 157.156 COW operations... COW system under §§ 157.10(e), 157.10a(a)(2), or 157.10c(b)(2) that has the Crude Oil Washing....10c(b)(2) shall ensure that during each COW operation— (a) The procedures listed in the Crude...

  1. 33 CFR 157.156 - COW operations: Meeting manual requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... CARRYING OIL IN BULK Crude Oil Washing (COW) System on Tank Vessels Cow Operations § 157.156 COW operations... COW system under § 157.10(e), § 157.10a(a)(2), or § 157.10c(b)(2) that has the Crude Oil Washing....10c(b)(2) shall ensure that during each COW operation— (a) The procedures listed in the Crude...

  2. 33 CFR 157.156 - COW operations: Meeting manual requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... CARRYING OIL IN BULK Crude Oil Washing (COW) System on Tank Vessels Cow Operations § 157.156 COW operations... COW system under §§ 157.10(e), 157.10a(a)(2), or 157.10c(b)(2) that has the Crude Oil Washing....10c(b)(2) shall ensure that during each COW operation— (a) The procedures listed in the Crude...

  3. 33 CFR 157.156 - COW operations: Meeting manual requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... CARRYING OIL IN BULK Crude Oil Washing (COW) System on Tank Vessels Cow Operations § 157.156 COW operations... COW system under §§ 157.10(e), 157.10a(a)(2), or 157.10c(b)(2) that has the Crude Oil Washing....10c(b)(2) shall ensure that during each COW operation— (a) The procedures listed in the Crude...

  4. 33 CFR 157.156 - COW operations: Meeting manual requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... CARRYING OIL IN BULK Crude Oil Washing (COW) System on Tank Vessels Cow Operations § 157.156 COW operations... COW system under §§ 157.10(e), 157.10a(a)(2), or 157.10c(b)(2) that has the Crude Oil Washing....10c(b)(2) shall ensure that during each COW operation— (a) The procedures listed in the Crude...

  5. Clinical analysis of bronchoscopic cryotherapy in 156 pediatric patients.

    PubMed

    Ni, Caiyun; Yu, Huafeng; Han, Xiaorong; Meng, Chen; Zhang, Yanqin

    2017-01-01

    The aim of this study was to investigate the efficacy and safety of bronchoscopic cryotherapy for pediatric poor ventilation. A total of 156 pediatric patients with airway stenosis and obstruction as well as pulmonary atelectasis received bronchoscopic cryotherapy. Treatment efficacy was evaluated on bronchoscopy Before cryotherapy and after the last cryotherapy treatment. Pulmonary atelectasis was assessed according to range of atelectasis on chest computed tomography (CT), and tracheobronchial stenosis according to pulmonary function, tidal volume analysis and dyspnea index. The 154 patients with effective treatment had patent airway, smooth mucosa and resolved atelectasis. In the two patients with ineffective treatment, however, the airway was not smooth and the range of pulmonary atelectasis was reduced by <30%. Among the 156 patients, 136 had markedly effective treatment, with CT pulmonary atelectasis recovery >70%. The width of the main airway significantly increased approximately 50% and the tidal volume or capacity increased 100%. Effective treatment was identified in 18 patients (18/156), with CT pulmonary atelectasis area reduced 30-70%. Ineffective treatment was noted in two patients, with CT pulmonary atelectasis area reduced by <30%. No complications were noted in any patients during or after operation. No recurrence was noted on follow up of 2-24 months. Bronchoscopic cryotherapy is effective and safe for dyspnea caused by airway obstruction, and wide application in clinic is recommended. © 2016 Japan Pediatric Society.

  6. Feasibility of repeated sequential treatments of RIF-1 tumors with photodynamic therapy (PDT) using lutetium texaphyrin (PCI-0123)

    NASA Astrophysics Data System (ADS)

    Miles, Dale R.; Parker, Lynn M.; Thiemann, Patricia A.; Woodburn, Kathryn W.; Young, Stuart W.

    1997-05-01

    Lutetium texaphyrin (PCI-0123) is currently in clinical trials as a PDT agent for the treatment of cancer patients. The drug is cleared rapidly from the plasma, and photoirradiation can be performed shortly after drug administration.T He photosensitizer as yet does not appear to elicit any significant skin photosensitivity. These characteristics favor frequent multiple PDT treatments with PCI-0123. In order to support repeated PDT treatments in the clinic, the safety of multiple drug dosing was studied in rats and mice. In rats, each group received 5 consecutive daily intravenous administrations of 5, 15, 30, or 60 mg/kg/day of PCI-0123. There were no deaths in any of the groups, and no drug-related effects were detected in the 5 mg/kg/day group. In mice, there were no observable signs of toxicity after consecutive daily administration of 10 micrometers ol/kg/day of PCI-0123 for 13 days. The feasibility and efficacy of repeated PDT treatments were assessed in C3H mice bearing RIF-1 tumors. Repeated PDT proved to be superior to a single PDT treatment. Repeated PDT treatments were well tolerated. Seven PDT treatments were administered over a nine day period without significant toxicity while achieving good therapeutic responses. All six groups receiving repeated PDT treatments showed an improved response compared to groups receiving a single PDT cycle, and the improvement was statistically significant for five of these groups. Sixty-two percent of mice receiving four sequential daily treatments were cured, and daily treatments were superior to regimens with longer intervals between PDT cycles.

  7. In vivo reflectance measurement of optical properties, blood oxygenation and motexafin lutetium uptake in canine large bowels, kidneys and prostates.

    PubMed

    Solonenko, Michael; Cheung, Rex; Busch, Theresa M; Kachur, Alex; Griffin, Gregory M; Vulcan, Theodore; Zhu, Timothy C; Wang, Hsing-Wen; Hahn, Stephen M; Yodh, A G

    2002-03-21

    Motexafin lutetium (MLu) is a second-generation photosensitizer for photodynamic therapy (PDT) of cancer. We have developed and applied a diffuse optical reflectance spectrometer for in vivo measurement of MLu uptake, optical properties, haemoglobin concentration and haemoglobin oxygen saturation in normal canine large bowels, kidneys and prostates. The probe consists of a broadband fibre-optic-coupled light source and detector fibres placed at various distances from the source fibre to collect reflected light. An analysis based on the diffusion approximation of the photon transport equation was used to recover tissue optical properties from the reflectance measurements. The instrumentation and analysis methods were validated using measurements from homogeneous, highly scattering phantoms with known MLu concentrations. The same techniques were then used to estimate chromophore concentrations of normal canine large bowels, kidneys and prostates. We estimated (mean (standard deviation)) total haemoglobin concentrations of 119 (25), 340 (92) and 51 (11) microM in the large bowels, kidneys and prostates of four dogs, respectively; tissue blood oxygen saturations in these same organs were 75 (15), 76 (21) and 74 (16) per cent, respectively. Tissue MLu concentrations (mg l(-1)) were estimated from data taken 3.5 h after injection of a 2 mg kg(-1) injected dose; data from three dogs gave concentrations of 2.4 (0.4) in large bowels, 6.8 (1.3) in kidneys and 2.2 (1.1) in prostates. The reduced scattering coefficients, mu's, estimated for large bowels, kidneys and prostates at 730 nm were, respectively: 10.1 (1.3), 19.6 (4.0) and 12.7 (0.6) cm(-1). We observed significant variability in MLu uptake, tissue scattering and haemoglobin concentration between organs and even between the same organ in different dogs. This class of in situ optical property measurement may be desirable to individualize PDT drug and light delivery.

  8. Semiautomated labelling and fractionation of yttrium-90 and lutetium-177 somatostatin analogues using disposable syringes and vials.

    PubMed

    Asti, Mattia; Atti, Giulia; Iori, Michele; Farioli, Daniela; Filice, Angelina; Versari, Annibale

    2012-11-01

    The treatment of tumours expressing somatostatin receptors with yttrium-90 (90Y)-labelled and lutetium-177 (177Lu)-labelled somatostatin analogues is one of the most interesting therapeutic approaches adopted in nuclear medicine in recent years. However, the process of synthesis and fractionation of these radiopharmaceuticals is still mainly carried out manually despite the high radiation exposure to the operators and the need to comply with good manufacturing practices. In this study a semiautomatic synthesizer [automatic dose dispenser (ADD-2)] using only disposable syringes and vials has been presented. Small-scale syntheses (185-555 MBq) of 90Y/177Lu-DOTATATE were performed by adding the appropriate amount of peptide to a 90Y/177Lu chloride solution (n=10). The radionuclide/peptide molar ratio was 1 : 17 and 1 : 2 for 90Y and 177Lu, respectively. The solutions were buffered to 4.6 pH by ascorbate buffer and heated at 90°C for 30 min. Radiochemical purity was assessed by two independent radio-thin-layer chromatography systems. The solutions were fractioned to mimic the preparation of patient doses. All synthesis and fractionation steps were performed using ADD-2. The radiochemical yield was 92 ± 3% for 90Y and 97 ± 1% for 177Lu labelling. Radiochemical purity was more than 99.5%. The accuracy and reproducibility of the instrument in transferring and fractionating radioactive solutions were high (maximal error ≈ 5%). ADD-2 appears suitable for use in clinical preparations of 90Y/177Lu-DOTATATE with therapeutic amounts of precursors (20-30 GBq). The operator's exposure to radiation by using ADD-2 in comparison with manual preparations is under investigation.

  9. A novel glucose sensor using lutetium phthalocyanine as redox mediator in reduced graphene oxide conducting polymer multifunctional hydrogel.

    PubMed

    Al-Sagur, H; Komathi, S; Khan, M A; Gurek, A G; Hassan, A

    2017-06-15

    Herein, we report a scalable synthesis of multifunctional conducting polyacrylic acid (PAA) hydrogel (MFH) integrated with reduced grapheme oxide (rGO), vinyl substituted polyaniline (VS-PANI) and lutetium Phthalocyanine (LuPc2) as three dimensional robust matrix for glucose oxidase (GOx) immobilization (PAA-rGO/VS-PANI/LuPc2/GOx-MFH). We have integrated the multicomponents such as PAA with rGO, and VS-PANI through free radical polymerization using methylene bis-acrylamide, and ammonium persulphate as the cross linker and initiator. The LuPc2 was then doped to form multifunctional hydrogel (PAA-rGO/VS-PANI/LuPc2-MFH). Finally, biosensor was fabricated by immobilizing GOx into PAA-rGO/VS-PANI/LuPc2-MFH and subsequently used for electrochemical detection of glucose. The PAA-rGO/VS-PANI/LuPc2/GOx-MFH biosensor exhibited high sensitivity (15.31μAmM(-1)cm(-2)) for the detection of glucose over a concentration range of 2-12mM with a low detection limit of 25µm. The PAA-rGO/VS-PANI/LuPc2-MFH biosensor showed a fast response time (1s) to the addition of glucose with high storage stability of 3 months. The real sample analysis reveals that PAA-rGO/VS-PANI/LuPc2/GOx-MFH could be effectively used as an electrochemical biosensor in industrial as well clinical diagnosis. Copyright © 2016 Elsevier B.V. All rights reserved.

  10. Quantifying public radiation exposure related to lutetium-177 octreotate therapy for the development of a safe outpatient treatment protocol.

    PubMed

    Olmstead, Craig; Cruz, Kyle; Stodilka, Robert; Zabel, Pamela; Wolfson, Robert

    2015-02-01

    Radionuclide therapies, including treatment of neuroendocrine tumors with lutetium-177 (Lu-177) octreotate, often involve hospital admission to minimize radiation exposure to the public. Overnight admission due to Lu-177 octreotate therapy incurs additional cost for the hospital and is an inconvenience for the patient. This study endeavors to characterize the potential radiation risk to caregivers and the public should Lu-177 octreotate therapies be performed on an outpatient basis. Dose rate measurements of radiation emanating from 10 patients were taken 30 min, 4, and 20 h after initiation of Lu-177 octreotate therapy. Instadose radiation dose measurement monitors were also placed around the patients' rooms to assess the potential cumulative radiation exposure during the initial 30 min-4 h after treatment (simulating the hospital-based component of the outpatient model) as well as 4-20 h after treatment (simulating the discharged outpatient portion). The mean recorded dose rate at 30 min, 4, and 20 h after therapy was 20.4, 14.0, and 6.6 μSv/h, respectively. The majority of the cumulative dose readings were below the minimum recordable threshold of 0.03 mSv, with a maximum dose recorded of 0.18 mSv. Given the low dose rate and cumulative levels of radiation measured, the results support that an outpatient Lu-177 octreotate treatment protocol would not jeopardize public safety. Nevertheless, the concept of ALARA still requires that detailed radiation safety protocols be developed for Lu-177 octreotate outpatients to minimize radiation exposure to family members, caregivers, and the general public.

  11. Bioelectronic tongue based on lipidic nanostructured layers containing phenol oxidases and lutetium bisphthalocyanine for the analysis of grapes.

    PubMed

    Medina-Plaza, C; de Saja, J A; Rodriguez-Mendez, M L

    2014-07-15

    In this work, a multisensor system formed by nanostructured voltammetric biosensors based on phenol oxidases (tyrosinase and laccase) has been developed. The enzymes have been incorporated into a biomimetic environment provided by a Langmuir-Blodgett (LB) film of arachidic acid (AA). Lutetium bisphthalocyanine (LuPc2) has also been introduced in the films to act as electron mediator. The incorporation of the enzymes to the floating layers to form Tyr/AA/LuPc2 and Lac/AA/LuPc2 films has been confirmed by the expansion in the surface pressure isotherms and by the AFM images. The voltammetric response towards six phenolic compounds demonstrates the enhanced performance of the biosensors that resulted from a preserved activity of the tyrosinase and laccase combined with the electron transfer activity of LuPc2. Biosensors show improved detection limits in the range of 10(-7)-10(-8) mol L(-1). An array formed by three sensors AA/LuPc2, Tyr/AA/LuPc2 and Lac/AA/LuPc2 has been employed to discriminate phenolic antioxidants of interest in the food industry. The Principal Component Analysis scores plot has demonstrated that the multisensor system is able to discriminate phenols according to the number of phenolic groups attached to the structure. The system has also been able to discriminate grapes of different varieties according to their phenolic content. This good performance is due to the combination of four factors: the high functionality of the enzyme obtained using a biomimetic immobilization, the signal enhancement caused by the LuPc2 mediator, the improvement in the selectivity induced by the enzymes and the complementary activity of the enzymatic sensors demonstrated in the loading plots. Copyright © 2014 Elsevier B.V. All rights reserved.

  12. Search for Fingerprints of Tetrahedral Symmetry in 156Gd

    NASA Astrophysics Data System (ADS)

    Doan, Q. T.; Curien, D.; Stęzowski, O.; Dudek, J.; Mazurek, K.; Góźdź, A.; Piot, J.; DuchÊNe, G.; Gall, B.; Molique, H.; Richet, M.; Medina, P.; Guinet, D.; Redon, N.; Schmitt, Ch.; Jones, P.; Peura, P.; Ketelhut, S.; Nyman, M.; Jakobsson, U.; Greenlees, P. T.; Julin, R.; Juutinen, S.; Rahkila, P.; Maj, A.; Zuber, K.; Bednarczyk, P.; Schunck, N.; Dobaczewski, J.; Astier, A.; Deloncle, I.; Verney, D.; de Angelis, G.; Gerl, J.

    2009-03-01

    Theoretical predictions suggest the presence of tetrahedral symmetry as an explanation for the vanishing intra-band E2 transitions at the bottom of the odd-spin negative-parity band in 156Gd. The present study reports on experiment performed to address this phenomenon. It allowed to remove certain ambiguouities related to the intra-band E2 transitions in the negative-parity bands, to determine the new inter-band transitions and reduced probability ratios B(E2)/B(E1) and, for the first time, to determine the experimental uncertainties related to the latter observable.

  13. Antimalarial Activity of KAF156 in Falciparum and Vivax Malaria.

    PubMed

    White, Nicholas J; Duong, Tran T; Uthaisin, Chirapong; Nosten, François; Phyo, Aung P; Hanboonkunupakarn, Borimas; Pukrittayakamee, Sasithon; Jittamala, Podjanee; Chuthasmit, Kittiphum; Cheung, Ming S; Feng, Yiyan; Li, Ruobing; Magnusson, Baldur; Sultan, Marc; Wieser, Daniela; Xun, Xiaolei; Zhao, Rong; Diagana, Thierry T; Pertel, Peter; Leong, F Joel

    2016-09-22

    KAF156 belongs to a new class of antimalarial agents (imidazolopiperazines), with activity against asexual and sexual blood stages and the preerythrocytic liver stages of malarial parasites. We conducted a phase 2, open-label, two-part study at five centers in Thailand and Vietnam to assess the antimalarial efficacy, safety, and pharmacokinetic profile of KAF156 in adults with acute Plasmodium vivax or P. falciparum malaria. Assessment of parasite clearance rates in cohorts of patients with vivax or falciparum malaria who were treated with multiple doses (400 mg once daily for 3 days) was followed by assessment of the cure rate at 28 days in a separate cohort of patients with falciparum malaria who received a single dose (800 mg). Median parasite clearance times were 45 hours (interquartile range, 42 to 48) in 10 patients with falciparum malaria and 24 hours (interquartile range, 20 to 30) in 10 patients with vivax malaria after treatment with the multiple-dose regimen and 49 hours (interquartile range, 42 to 54) in 21 patients with falciparum malaria after treatment with the single dose. Among the 21 patients who received the single dose and were followed for 28 days, 1 had reinfection and 7 had recrudescent infections (cure rate, 67%; 95% credible interval, 46 to 84). The mean (±SD) KAF156 terminal elimination half-life was 44.1±8.9 hours. There were no serious adverse events in this small study. The most common adverse events included sinus bradycardia, thrombocytopenia, hypokalemia, anemia, and hyperbilirubinemia. Vomiting of grade 2 or higher occurred in 2 patients, 1 of whom discontinued treatment because of repeated vomiting after receiving the single 800-mg dose. More adverse events were reported in the single-dose cohort, which had longer follow-up, than in the multiple-dose cohorts. KAF156 showed antimalarial activity without evident safety concerns in a small number of adults with uncomplicated P. vivax or P. falciparum malaria. (Funded by Novartis and

  14. Antimalarial Activity of KAF156 in Falciparum and Vivax Malaria

    PubMed Central

    White, Nicholas J.; Duong, Tran T.; Uthaisin, Chirapong; Nosten, François; Phyo, Aung P.; Hanboonkunupakarn, Borimas; Pukrittayakamee, Sasithon; Jittamala, Podjanee; Chuthasmit, Kittiphum; Cheung, Ming S.; Feng, Yiyan; Li, Ruobing; Magnusson, Baldur; Sultan, Marc; Wieser, Daniela; Xun, Xiaolei; Zhao, Rong; Diagana, Thierry T.; Pertel, Peter; Leong, F. Joel

    2016-01-01

    Background KAF156 belongs to a new class of antimalarial agents (imidazolopiperazines), with activity against asexual and sexual blood stages and the preerythrocytic liver stages of malarial parasites. Methods We conducted a phase 2, open-label, two-part study at five centers in Thailand and Vietnam to assess the antimalarial efficacy, safety, and pharmacokinetic profile of KAF156 in adults with acute Plasmodium vivax or P. falciparum malaria. Assessment of parasite clearance rates in cohorts of patients with vivax or falciparum malaria who were treated with multiple doses (400 mg once daily for 3 days) was followed by assessment of the cure rate at 28 days in a separate cohort of patients with falciparum malaria who received a single dose (800 mg). Results Median parasite clearance times were 45 hours (interquartile range, 42 to 48) in 10 patients with falciparum malaria and 24 hours (interquartile range, 20 to 30) in 10 patients with vivax malaria after treatment with the multiple-dose regimen and 49 hours (interquartile range, 42 to 54) in 21 patients with falciparum malaria after treatment with the single dose. Among the 21 patients who received the single dose and were followed for 28 days, 1 had reinfection and 7 had recrudescent infections (cure rate, 67%; 95% credible interval, 46 to 84). The mean (±SD) KAF156 terminal elimination half-life was 44.1±8.9 hours. There were no serious adverse events in this small study. The most common adverse events included sinus bradycardia, thrombocytopenia, hypokalemia, anemia, and hyperbilirubinemia. Vomiting of grade 2 or higher occurred in 2 patients, 1 of whom discontinued treatment because of repeated vomiting after receiving the single 800-mg dose. More adverse events were reported in the single-dose cohort, which had longer follow-up, than in the multiple-dose cohorts. Conclusions KAF156 showed antimalarial activity without evident safety concerns in a small number of adults with uncomplicated P. vivax or P

  15. Search for Fingerprints of Tetrahedral Symmetry in ^{156}Gd

    SciTech Connect

    Doan, Q. T.; Curien, D.; Stezowski, O.; Dudek, J.; Mazurek, K.; Gozdz, A.; Piot, J.; Duchene, G.; Gall, B.; Molique, H.; Richet, M.; Guinet, D.; Redon, N.; Schmitt, Ch.; Jones, P.; Peura, P.; Ketelhut, S.; Nyman, M.; Jakobsson, U.; Greenlees, P. T.; Julin, R.; Juutinen, S.; Rahkila, P.; Maj, A.; Zuber, K.; Bednarczyk, P.; Schunck, N.; Dobaczewski, J.; Astier, A.; Deloncle, I.; Verney, D.; Gerl, J.

    2009-01-01

    Theoretical predictions suggest the presence of tetrahedral symmetry as an explanation for the vanishing intra-band E2 transitions at the bottom of the odd-spin negative-parity band in ^{156}Gd. The present study reports on experiment performed to address this phenomenon. It allowed to remove certain ambiguities related to the intra-band E2 transitions in the negative-parity bands to determine the new inter-band transitions and reduced probability ratios B(E2)/B(E1) and, for the first time, to determine the experimental uncertainties related to the latter observable.

  16. Channel catfish (Ictalurus punctatus) CD156a mRNA sequence

    USDA-ARS?s Scientific Manuscript database

    CD156a, also known as A Disintegrin And Metalloproteinase domain 8 (ADAM8), is a member of ADAM family. We cloned, and sequenced the channel catfish CD156a transcript. The full-length of the CD156a cDNA consisted of 3035 nucleotides, including a 5’-untranslated region (UTR), an open reading frame ...

  17. 40 CFR 81.156 - Southern Maryland Intrastate Air Quality Control Region.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Quality Control Region. 81.156 Section 81.156 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) DESIGNATION OF AREAS FOR AIR QUALITY PLANNING PURPOSES Designation of Air Quality Control Regions § 81.156 Southern Maryland Intrastate Air Quality Control Region. The...

  18. 27 CFR 25.156 - Determination of tax on keg beer.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... keg beer. 25.156 Section 25.156 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS BEER Tax on Beer Determination of Tax § 25.156 Determination of tax on keg beer. (a) In determining the tax on beer removed in kegs, a barrel is regarded as...

  19. 10 CFR 431.156 - Energy and water conservation standards and effective dates.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Energy and water conservation standards and effective dates. 431.156 Section 431.156 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY EFFICIENCY PROGRAM... Standards § 431.156 Energy and water conservation standards and effective dates. Each commercial...

  20. 40 CFR 80.156 - Liability for violations of the interim detergent program controls and prohibitions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... interim detergent program controls and prohibitions. 80.156 Section 80.156 Protection of Environment... Detergent Gasoline § 80.156 Liability for violations of the interim detergent program controls and..., carrier, distributor, reseller, retailer, wholesale purchaser-consumer, oxygenate blender, or detergent...

  1. 40 CFR 80.156 - Liability for violations of the interim detergent program controls and prohibitions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... interim detergent program controls and prohibitions. 80.156 Section 80.156 Protection of Environment... Detergent Gasoline § 80.156 Liability for violations of the interim detergent program controls and..., carrier, distributor, reseller, retailer, wholesale purchaser-consumer, oxygenate blender, or detergent...

  2. 40 CFR 80.156 - Liability for violations of the interim detergent program controls and prohibitions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... interim detergent program controls and prohibitions. 80.156 Section 80.156 Protection of Environment... Detergent Gasoline § 80.156 Liability for violations of the interim detergent program controls and..., carrier, distributor, reseller, retailer, wholesale purchaser-consumer, oxygenate blender, or detergent...

  3. 40 CFR 80.156 - Liability for violations of the interim detergent program controls and prohibitions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... interim detergent program controls and prohibitions. 80.156 Section 80.156 Protection of Environment... Detergent Gasoline § 80.156 Liability for violations of the interim detergent program controls and..., carrier, distributor, reseller, retailer, wholesale purchaser-consumer, oxygenate blender, or detergent...

  4. 33 CFR 110.156 - Randall Bay, Freeport, Long Island, N.Y.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Island, N.Y. 110.156 Section 110.156 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.156 Randall Bay, Freeport, Long Island, N... available, may be assigned to any vessel by the Captain of the Port of Long Island Sound. (2) The Captain of...

  5. 33 CFR 110.156 - Randall Bay, Freeport, Long Island, N.Y.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Randall Bay, Freeport, Long Island, N.Y. 110.156 Section 110.156 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.156 Randall Bay, Freeport, Long Island, N...

  6. 33 CFR 110.156 - Randall Bay, Freeport, Long Island, N.Y.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Island, N.Y. 110.156 Section 110.156 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.156 Randall Bay, Freeport, Long Island, N... available, may be assigned to any vessel by the Captain of the Port of Long Island Sound. (2) The Captain of...

  7. 33 CFR 110.156 - Randall Bay, Freeport, Long Island, N.Y.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Randall Bay, Freeport, Long Island, N.Y. 110.156 Section 110.156 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.156 Randall Bay, Freeport, Long Island, N...

  8. 33 CFR 110.156 - Randall Bay, Freeport, Long Island, N.Y.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Island, N.Y. 110.156 Section 110.156 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.156 Randall Bay, Freeport, Long Island, N... available, may be assigned to any vessel by the Captain of the Port of Long Island Sound. (2) The Captain of...

  9. 40 CFR 156.78 - Precautionary statements for physical or chemical hazards.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    .../chemical hazards (e.g., oxidizing potential, conductivity, chemical reactions leading to production of... or chemical hazards. 156.78 Section 156.78 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Precautionary Statements § 156.78 Precautionary statements for physical or chemical hazards. (a)...

  10. 29 CFR 4.156 - Employees in bona fide executive, administrative, or professional capacity.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... professional capacity. 4.156 Section 4.156 Labor Office of the Secretary of Labor LABOR STANDARDS FOR FEDERAL....156 Employees in bona fide executive, administrative, or professional capacity. The term service..., administrative, or professional capacity as those terms are defined in 29 CFR part 541. Employees within the...

  11. 40 CFR 156.146 - Residue removal instructions for nonrefillable containers-rigid containers with dilutable...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... nonrefillable containers-rigid containers with dilutable pesticides. 156.146 Section 156.146 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS LABELING REQUIREMENTS FOR PESTICIDES AND DEVICES Container Labeling § 156.146 Residue removal instructions for nonrefillable containers...

  12. 40 CFR 156.146 - Residue removal instructions for nonrefillable containers-rigid containers with dilutable...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... nonrefillable containers-rigid containers with dilutable pesticides. 156.146 Section 156.146 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS LABELING REQUIREMENTS FOR PESTICIDES AND DEVICES Container Labeling § 156.146 Residue removal instructions for nonrefillable containers...

  13. 40 CFR 156.146 - Residue removal instructions for nonrefillable containers-rigid containers with dilutable...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... nonrefillable containers-rigid containers with dilutable pesticides. 156.146 Section 156.146 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS LABELING REQUIREMENTS FOR PESTICIDES AND DEVICES Container Labeling § 156.146 Residue removal instructions for nonrefillable containers...

  14. 40 CFR 156.146 - Residue removal instructions for nonrefillable containers-rigid containers with dilutable...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... nonrefillable containers-rigid containers with dilutable pesticides. 156.146 Section 156.146 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS LABELING REQUIREMENTS FOR PESTICIDES AND DEVICES Container Labeling § 156.146 Residue removal instructions for nonrefillable containers...

  15. 40 CFR 156.146 - Residue removal instructions for nonrefillable containers-rigid containers with dilutable...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... nonrefillable containers-rigid containers with dilutable pesticides. 156.146 Section 156.146 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS LABELING REQUIREMENTS FOR PESTICIDES AND DEVICES Container Labeling § 156.146 Residue removal instructions for nonrefillable containers...

  16. 27 CFR 25.156 - Determination of tax on keg beer.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... keg beer. 25.156 Section 25.156 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS BEER Tax on Beer Determination of Tax § 25.156 Determination of tax on keg beer. (a) In determining the tax on beer removed in kegs, a barrel is regarded as...

  17. 27 CFR 25.156 - Determination of tax on keg beer.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... keg beer. 25.156 Section 25.156 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY ALCOHOL BEER Tax on Beer Determination of Tax § 25.156 Determination of tax on keg beer. (a) In determining the tax on beer removed in kegs, a barrel is regarded as...

  18. 27 CFR 25.156 - Determination of tax on keg beer.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... keg beer. 25.156 Section 25.156 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS BEER Tax on Beer Determination of Tax § 25.156 Determination of tax on keg beer. (a) In determining the tax on beer removed in kegs, a barrel is regarded as...

  19. 27 CFR 25.156 - Determination of tax on keg beer.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... keg beer. 25.156 Section 25.156 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY ALCOHOL BEER Tax on Beer Determination of Tax § 25.156 Determination of tax on keg beer. (a) In determining the tax on beer removed in kegs, a barrel is regarded as...

  20. 40 CFR 156.78 - Precautionary statements for physical or chemical hazards.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    .../chemical hazards (e.g., oxidizing potential, conductivity, chemical reactions leading to production of... or chemical hazards. 156.78 Section 156.78 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Precautionary Statements § 156.78 Precautionary statements for physical or chemical hazards. (a)...

  1. 40 CFR 156.78 - Precautionary statements for physical or chemical hazards.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    .../chemical hazards (e.g., oxidizing potential, conductivity, chemical reactions leading to production of... or chemical hazards. 156.78 Section 156.78 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Precautionary Statements § 156.78 Precautionary statements for physical or chemical hazards. (a)...

  2. 75 FR 66412 - 60-Day Notice of Proposed Information Collection: DS-156, Nonimmigrant Visa Application, OMB...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-28

    ... Notice of Proposed Information Collection: DS-156, Nonimmigrant Visa Application, OMB Control Number 1405... Number: DS-156. Respondents: Nonimmigrant visa applicants. Estimated Number of Respondents: 800,000... must read DS-156 Reauthorization). Mail (paper, disk, or CD-ROM submissions): Chief, Legislation and...

  3. 47 CFR 80.148 - Watch on 156.8 MHz (Channel 16).

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 5 2014-10-01 2014-10-01 false Watch on 156.8 MHz (Channel 16). 80.148 Section... Watches § 80.148 Watch on 156.8 MHz (Channel 16). Each compulsory vessel, while underway, must maintain a watch for radiotelephone distress calls on 156.800 MHz whenever such station is not being used...

  4. 47 CFR 80.148 - Watch on 156.8 MHz (Channel 16).

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 5 2013-10-01 2013-10-01 false Watch on 156.8 MHz (Channel 16). 80.148 Section... Watches § 80.148 Watch on 156.8 MHz (Channel 16). Each compulsory vessel, while underway, must maintain a watch for radiotelephone distress calls on 156.800 MHz whenever such station is not being used...

  5. 47 CFR 80.148 - Watch on 156.8 MHz (Channel 16).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Watch on 156.8 MHz (Channel 16). 80.148 Section... Watches § 80.148 Watch on 156.8 MHz (Channel 16). Each compulsory vessel, while underway, must maintain a watch for radiotelephone distress calls on 156.800 MHz whenever such station is not being used...

  6. 47 CFR 80.148 - Watch on 156.8 MHz (Channel 16).

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 5 2011-10-01 2011-10-01 false Watch on 156.8 MHz (Channel 16). 80.148 Section... Watches § 80.148 Watch on 156.8 MHz (Channel 16). Each compulsory vessel, while underway, must maintain a watch for radiotelephone distress calls on 156.800 MHz whenever such station is not being used...

  7. 47 CFR 80.148 - Watch on 156.8 MHz (Channel 16).

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 5 2012-10-01 2012-10-01 false Watch on 156.8 MHz (Channel 16). 80.148 Section... Watches § 80.148 Watch on 156.8 MHz (Channel 16). Each compulsory vessel, while underway, must maintain a watch for radiotelephone distress calls on 156.800 MHz whenever such station is not being used...

  8. 40 CFR 156.78 - Precautionary statements for physical or chemical hazards.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    .../chemical hazards (e.g., oxidizing potential, conductivity, chemical reactions leading to production of... or chemical hazards. 156.78 Section 156.78 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Precautionary Statements § 156.78 Precautionary statements for physical or chemical hazards. (a) Requirement...

  9. 45 CFR 156.245 - Treatment of direct primary care medical homes.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    .... 156.245 Section 156.245 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS HEALTH INSURANCE ISSUER STANDARDS UNDER THE AFFORDABLE CARE ACT, INCLUDING STANDARDS RELATED TO EXCHANGES Qualified Health Plan Minimum Certification Standards § 156.245 Treatment...

  10. 45 CFR 156.270 - Termination of coverage for qualified individuals.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    .... 156.270 Section 156.270 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS HEALTH INSURANCE ISSUER STANDARDS UNDER THE AFFORDABLE CARE ACT, INCLUDING STANDARDS RELATED TO EXCHANGES Qualified Health Plan Minimum Certification Standards § 156.270...

  11. Lu2@C2n (2n = 82, 84, 86): Crystallographic Evidence of Direct Lu-Lu Bonding between Two Divalent Lutetium Ions Inside Fullerene Cages.

    PubMed

    Shen, Wangqiang; Bao, Lipiao; Wu, Yongbo; Pan, Changwang; Zhao, Shasha; Fang, Hongyun; Xie, Yunpeng; Jin, Peng; Peng, Ping; Li, Fang-Fang; Lu, Xing

    2017-07-26

    Although most of the M2C2n-type metallofullerenes (EMFs) tend to form carbide cluster EMFs, we report herein that Lu-containing EMFs Lu2C2n (2n = 82, 84, 86) are actually dimetallofullerenes (di-EMFs), namely, Lu2@Cs(6)-C82, Lu2@C3v(8)-C82, Lu2@D2d(23)-C84, and Lu2@C2v(9)-C86. Unambiguous X-ray results demonstrate the formation of a Lu-Lu single bond between two lutetium ions which transfers four electrons in total to the fullerene cages, thus resulting in a formal divalent state for each Lu ion. Population analysis indicates that each Lu atom formally donates a 5d electron and a 6s electron to the cage with the remaining 6s electron shared with the other Lu atom to form a Lu-Lu single bond so that only four electrons are transferred to the fullerene cages with the formal divalent valence for each lutetium ion. Accordingly, we confirmed both experimentally and theoretically that the dominating formation of di-EMFs is thermodynamically very favorable for Lu2C2n isomers.

  12. Beta emitters rhenium-188 and lutetium-177 are equally effective in radioimmunotherapy of HPV-positive experimental cervical cancer.

    PubMed

    Phaeton, Rebecca; Jiang, Zewei; Revskaya, Ekaterina; Fisher, Darrell R; Goldberg, Gary L; Dadachova, Ekaterina

    2016-01-01

    Cervical cancer caused by the infection with the human papillomavirus (HPV) remains the fourth leading killer of women worldwide. Therefore, more efficacious treatments are needed. We are developing radioimmunotherapy (RIT) of HPV-positive cervical cancers by targeting E6 and E7 viral oncoproteins expressed by the cancer cells with the radiolabeled monoclonal antibodies (mAbs). To investigate the influence of different radionuclides on the RIT efficacy-we performed RIT of experimental cervical cancer with Rhenium-188 ((188) Re) and Lutetium-177 ((177) Lu)-labeled mAb C1P5 to E6. The biodistribution of (188) Re- and (177) Lu-labeled C1P5 was performed in nude female mice bearing CasKi cervical cancer xenografts and the radiation dosimetry calculations for the tumors and organs were carried out. For RIT the mice were treated with 7.4 MBq of either (188) Re-C1P5 or (177) Lu-C1P5 or left untreated, and observed for their tumor size for 28 days. The levels of (188) Re- and (177) Lu-C1P5 mAbs-induced double-strand breaks in CasKi tumors were compared on days 5 and 10 post treatment by staining with anti-gamma H2AX antibody. The radiation doses to the heart and lungs were similar for both (177) Lu-C1P5 and (188) Re-C1P5. The dose to the liver was five times higher for (177) Lu-C1P5. The doses to the tumor were 259 and 181 cGy for (177) Lu-C1P5 and (188) Re-C1P5, respectively. RIT with either (177) Lu-C1P5 or (188) Re-C1P5 was equally effective in inhibiting tumor growth when each was compared to the untreated controls (P = 0.001). On day 5 there was a pronounced staining for gamma H2AX foci in (177) Lu-C1P5 group only and on day 10 it was observed in both (177) Lu-C1P5 and (188) Re-C1P5 groups. (188) Re- and (177) Lu-labeled mAbs were equally effective in arresting the growth of CasKi cervical tumors. Thus, both of these radionuclides are candidates for the clinical trials of this approach in patients with advanced, recurrent or metastatic cervical cancer. © 2015 The

  13. Performance Evaluation of microPET: A High-Resolution Lutetium Oxyorthosilicate PET Scanner for Animal Imaging

    PubMed Central

    Chatziioannou, Arion F.; Cherry, Simon R.; Shao, Yiping; Silverman, Robert W.; Meadors, Ken; Farquhar, Thomas H.; Pedarsani, Marjan; Phelps, Michael E.

    2012-01-01

    A new dedicated PET scanner, microPET, was designed and developed at the University of California, Los Angeles, for imaging small laboratory animals. The goal was to provide a compact system with superior spatial resolution at a fraction of the cost of a clinical PET scanner. Methods The system uses fiberoptic readout of individually cut lutetium oxyorthosilicate (LSO) crystals to achieve high spatial resolution. Each microPET detector consists of an 8 × 8 array of 2 × 2 × 10-mm LSO scintillation crystals that are coupled to a 64-channel photomultiplier tube by optical fibers. The tomograph consists of 30 detectors in a continuous ring with a 17.2-cm diameter and fields of view (FOVs) of 11.25 cm in the transaxial direction and 1.8 cm in the axial direction. The system has eight crystal rings and no interplane septa. It operates exclusively in the three-dimensional mode and has an electronically controlled bed that is capable of wobbling with a radius of 300 µm. We describe the performance of the tomograph in terms of its spatial, energy and timing resolution, as well as its sensitivity and counting-rate performance. We also illustrate its overall imaging performance with phantom and animal studies that demonstrate the potential applications of this device to biomedical research. Results Images reconstructed with three-dimensional filtered back projection show a spatial resolution of 1.8 mm at the center of the FOV (CFOV), which remains < 2.5 mm for the central 5 cm of the transaxial FOV. The resulting volumetric resolution of the system is < 8 µL. The absolute system sensitivity measured with a 0.74 MBq (20 µCi) 68Ge point source at the CFOV is 5.62 Hz/kBq. The maximum noise equivalent counting rate obtained with a 6.4-cm diameter cylinder spanning the central 56% of the FOV is 10 kcps, whereas the scatter fraction is 37% at the CFOV for an energy window of 250–650 keV and the same diameter cylinder. Conclusion This is the first PET scanner to use the new

  14. Chemoradiation therapy using cyclopamine-loaded liquid-lipid nanoparticles and lutetium-177-labeled core-crosslinked polymeric micelles.

    PubMed

    You, Jian; Zhao, Jun; Wen, Xiaoxia; Wu, Chunhui; Huang, Qian; Guan, Fada; Wu, Richard; Liang, Dong; Li, Chun

    2015-03-28

    Cyclopamine (CPA), a potent inhibitor of the Hedgehog pathway, has produced promising anticancer results in a number of preclinical studies. CPA has also been found to enhance tumor response to radiation therapy. However, CPA is water insoluble. A drug delivery system suitable for systemic administration of CPA is needed before CPA can be considered for clinical translation. We hypothesized that CPA solubilized in a liquid-lipid nanoparticle system (CPA-LLP) for intravenous injection would have desirable pharmacokinetic properties and increased anticancer efficacy. We further hypothesized that CPA-LLP would enhance the response of tumor cells to targeted radiotherapy delivered selectively through intratumoral injection of lutetium-177 bound to core-crosslinked polymeric micelles (CCPM-(177)Lu). We tested the combination therapy in 4T1 murine breast cancer and Miapaca-2 human pancreatic adenocarcinoma models. The results showed that CPA-LLP had higher antitumor cytotoxicity than free CPA (IC50 values [mean±SEM]: 2.7±0.2μM vs. 11.3±1.2μM against 4T1 cells; 1.8±0.2 vs. 17.1±1.26μM against Miapaca-2 cells; p<0.0001). In both cell lines, CPA-LLP resulted in significantly lower clonogenicity than free CPA (p<0.05). Moreover, in both cell lines, CPA-LLP significantly enhanced the cell response to CCPM-(177)Lu radiotherapy as measured by clonogenic assay (p<0.05). In 4T1 and Miapaca-2 mouse xenograft models, the combination of CPA-LLP and CCPM-(177)Lu delayed tumor growth more than either monotherapy did alone. In the 4T1 tumor model, tumor size at 16days after treatment was significantly smaller with the combination therapy than with all the other treatments. In the Miapaca-2 model, the combination therapy resulted in the highest rate of mouse survival and prevented tumor relapse. In conclusion, the combination of CPA-LLP and CCPM-(177)Lu was an effective strategy for treating breast and pancreatic cancer and deserves further investigation. Copyright © 2015

  15. 45 CFR 156.810 - Bases and process for decertification of a QHP offered by an issuer through a Federally...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... transparency and marketing standards in §§ 156.220 and 156.225; (4) The QHP issuer substantially fails to....230 related to network adequacy standards or, § 156.235 related to inclusion of essential...

  16. 45 CFR 156.810 - Bases and process for decertification of a QHP offered by an issuer through a Federally...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... transparency and marketing standards in §§ 156.220 and 156.225; (4) The QHP issuer substantially fails to... related to network adequacy standards or, § 156.235 related to inclusion of essential community...

  17. An Insight into microRNA156 Role in Salinity Stress Responses of Alfalfa

    PubMed Central

    Arshad, Muhammad; Gruber, Margaret Y.; Wall, Ken; Hannoufa, Abdelali

    2017-01-01

    Salinity is one of the major abiotic stresses affecting alfalfa productivity. Developing salinity tolerant alfalfa genotypes could contribute to sustainable crop production. The functions of microRNA156 (miR156) have been investigated in several plant species, but so far, no studies have been published that explore the role of miR156 in alfalfa response to salinity stress. In this work, we studied the role of miR156 in modulating commercially important traits of alfalfa under salinity stress. Our results revealed that overexpression of miR156 increased biomass, number of branches and time to complete growth stages, while it reduced plant height under control and salinity stress conditions. We observed a miR156-related reduction in neutral detergent fiber under non-stress, and acid detergent fiber under mild salinity stress conditions. In addition, enhanced total Kjeldahl nitrogen content was recorded in miR156 overexpressing genotypes under severe salinity stress. Furthermore, alfalfa genotypes overexpressing miR156 exhibited an altered ion homeostasis under salinity conditions. Under severe salinity stress, miR156 downregulated SPL transcription factor family genes, modified expression of other important transcription factors, and downstream salt stress responsive genes. Taken together, our results reveal that miR156 plays a role in mediating physiological and transcriptional responses of alfalfa to salinity stress. PMID:28352280

  18. An Insight into microRNA156 Role in Salinity Stress Responses of Alfalfa.

    PubMed

    Arshad, Muhammad; Gruber, Margaret Y; Wall, Ken; Hannoufa, Abdelali

    2017-01-01

    Salinity is one of the major abiotic stresses affecting alfalfa productivity. Developing salinity tolerant alfalfa genotypes could contribute to sustainable crop production. The functions of microRNA156 (miR156) have been investigated in several plant species, but so far, no studies have been published that explore the role of miR156 in alfalfa response to salinity stress. In this work, we studied the role of miR156 in modulating commercially important traits of alfalfa under salinity stress. Our results revealed that overexpression of miR156 increased biomass, number of branches and time to complete growth stages, while it reduced plant height under control and salinity stress conditions. We observed a miR156-related reduction in neutral detergent fiber under non-stress, and acid detergent fiber under mild salinity stress conditions. In addition, enhanced total Kjeldahl nitrogen content was recorded in miR156 overexpressing genotypes under severe salinity stress. Furthermore, alfalfa genotypes overexpressing miR156 exhibited an altered ion homeostasis under salinity conditions. Under severe salinity stress, miR156 downregulated SPL transcription factor family genes, modified expression of other important transcription factors, and downstream salt stress responsive genes. Taken together, our results reveal that miR156 plays a role in mediating physiological and transcriptional responses of alfalfa to salinity stress.

  19. MicroRNA156 improves drought stress tolerance in alfalfa (Medicago sativa) by silencing SPL13.

    PubMed

    Arshad, Muhammad; Feyissa, Biruk A; Amyot, Lisa; Aung, Banyar; Hannoufa, Abdelali

    2017-05-01

    Alfalfa (Medicago sativa) is an important forage crop that is often grown in areas that frequently experience drought and water shortage. MicroRNA156 (miR156) is an emerging tool for improving various traits in plants. We tested the role of miR156d in drought response of alfalfa, and observed a significant improvement in drought tolerance of miR156 overexpression (miR156OE) alfalfa genotypes compared to the wild type control (WT). In addition to higher survival and reduced water loss, miR156OE genotypes also maintained higher stomatal conductance compared to WT during drought stress. Furthermore, we observed an enhanced accumulation of compatible solute (proline) and increased levels of abscisic acid (ABA) and antioxidants in miR156OE genotypes. Similarly, alfalfa plants with reduced expression of miR156-targeted SPL13 showed reduced water loss and enhanced stomatal conductance, chlorophyll content and photosynthetic assimilation. Several genes known to be involved in drought tolerance were differentially expressed in leaf and root of miR156 overexpression plants. Taken together, our findings reveal that miR156 improves drought tolerance in alfalfa at least partially by silencing SPL13. Crown Copyright © 2017. Published by Elsevier B.V. All rights reserved.

  20. Initial stages of Lutetium growth on Si (111)-7 × 7 probed by STM and core-level photoelectron spectroscopy

    NASA Astrophysics Data System (ADS)

    Smykalla, Lars; Shukrynau, Pavel; Hietschold, Michael

    2017-09-01

    The interaction of small amounts of Lutetium with the Si (111)-7 × 7 reconstructed surface was investigated in detail using a combination of Scanning Tunneling Microscopy (STM) and Photoelectron Spectroscopy (XPS and UPS). Various immobile and also fastly moving atoms and nanocluster were found in the initial growth of the Lu/Si interface. Density functional theory calculations and photoelectron spectroscopy results suggest that the most attractive adsorption sites for the Lu atoms are basins around Si rest-atoms and there is no strong interaction between Lu and Si at the initial steps of film growth. However Lu nanocluster could also be found on other adsorption sites which results in a different voltage dependence in STM. Coverage-dependent STM images reveal the growth of a closed Lu metal overlayer by joining of the clusters. The existence of a stoichiometric Lu silicide compound was not detected on the surface in the initial growth for deposition at room temperature.