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Sample records for lutetium 176 target

  1. Half-life measurements of lutetium-176 using underground HPGe-detectors.

    PubMed

    Hult, Mikael; Vidmar, Tim; Rosengård, Ulf; Marissens, Gerd; Lutter, Guillaume; Sahin, Namik

    2014-05-01

    The half-life of (176)Lu was determined by measuring the (176)Lu activity in metallic lutetium foils. Three different HPGe-detectors located 225 m underground were employed for the study. Measurements using the sum-peak method were performed and resulted in an average massic activity of (52.61±0.36) Bq g(-1). The foils were of natural isotopic abundance so using the massic activity and the value of the natural isotopic abundance of (2.59±0.01)%, a half-life of (3.722±0.029)×10(10)a could be calculated.

  2. Indirect Production of No Carrier Added (NCA) (177)Lu from Irradiation of Enriched (176)Yb: Options for Ytterbium/Lutetium Separation.

    PubMed

    Dash, Ashutosh; Chakravarty, Rubel; Knapp, Furn F Russ; Pillai, Ambikalmajan M R

    2015-01-01

    This article presents a concise review of the production of no-carrier-added (NCA) (177)Lu by the 'indirect' route by irradiating ytterbium-176 ((176)Yb)-enriched targets. The success of this production method depends on the ability to separate the microscopic amounts of NCA (177)Lu from bulk irradiated ytterbium targets. The presence of Yb(+3) from the target in the final processed (177)Lu will adversely affect the quality of (177)Lu by decreasing the specific activity and competing with Lu(+3) complexation since ytterbium will follow the same coordination chemistry. Ytterbium and lutetium are adjacent members of the lanthanide family with very similar chemical properties which makes the separation of one from the other a challenging task. This review provides a summary of the methods developed for the separation and purification of NCA (177)Lu from neutron irradiated (176)Yb-enriched targets, a critical assessment of recent developments and a discussion of the current status of this (177)Lu production method.

  3. Production of No-Carrier Added Lutetium-177 by Irradiation of Enriched Ytterbium-176.

    PubMed

    Tarasov, Valery A; Andreev, Oleg I; Romanov, Evgeny G; Kuznetsov, Rostislav A; Kupriyanov, Vladimir V; Tselishchev, Ivan V

    2015-01-01

    Two methods of Lu-177 production are reviewed: irradiation of isotopically enriched Lu- 176 (direct way) and irradiation of ytterbium enriched with Yb-176 (indirect way). Based on neutronphysical calculations Lu-177 yield and specific activity were estimated for both methods. Lu-177 specific activity strongly depends on neutron flux density in the direct way, that is 75,000 Ci/g for 10- days irradiation in a neutron flux of 2.10(15) cm(-2) s(-1), and only 13,000 Ci/g after 30 days irradiation at neutron flux 1.10(14) cm(-2) s(-1). Irradiation of Yb-176 provides Lu-177 specific activity close to theoretical value (110,000 Ci/g). Neutron flux density effect Lu-177 yield, that is 530 Ci/g for 2.1015 cm(-2) s(-1) neutron flux density after 30 days irradiation. A procedure of isolation and purification of Lu-177 from irradiated targets is described based on combination of galvanostatic extraction of ytterbium followed by cation-exchange chromatography from alfa-hydroxyisobutirate solutions on BioRad AG(®)50W-X8 resin.

  4. Lutetium oxyorthosilicate (LSO) intrinsic activity correction and minimal detectable target activity study for SPECT imaging with a LSO-based animal PET scanner.

    PubMed

    Yao, Rutao; Ma, Tianyu; Shao, Yiping

    2008-08-21

    This work is part of a feasibility study to develop SPECT imaging capability on a lutetium oxyorthosilicate (LSO) based animal PET system. The SPECT acquisition was enabled by inserting a collimator assembly inside the detector ring and acquiring data in singles mode. The same LSO detectors were used for both PET and SPECT imaging. The intrinsic radioactivity of (176)Lu in the LSO crystals, however, contaminates the SPECT data, and can generate image artifacts and introduce quantification error. The objectives of this study were to evaluate the effectiveness of a LSO background subtraction method, and to estimate the minimal detectable target activity (MDTA) of image object for SPECT imaging. For LSO background correction, the LSO contribution in an image study was estimated based on a pre-measured long LSO background scan and subtracted prior to the image reconstruction. The MDTA was estimated in two ways. The empirical MDTA (eMDTA) was estimated from screening the tomographic images at different activity levels. The calculated MDTA (cMDTA) was estimated from using a formula based on applying a modified Currie equation on an average projection dataset. Two simulated and two experimental phantoms with different object activity distributions and levels were used in this study. The results showed that LSO background adds concentric ring artifacts to the reconstructed image, and the simple subtraction method can effectively remove these artifacts-the effect of the correction was more visible when the object activity level was near or above the eMDTA. For the four phantoms studied, the cMDTA was consistently about five times of the corresponding eMDTA. In summary, we implemented a simple LSO background subtraction method and demonstrated its effectiveness. The projection-based calculation formula yielded MDTA results that closely correlate with that obtained empirically and may have predicative value for imaging applications.

  5. Lutetium oxyorthosilicate (LSO) intrinsic activity correction and minimal detectable target activity study for SPECT imaging with a LSO-based animal PET scanner

    NASA Astrophysics Data System (ADS)

    Yao, Rutao; Ma, Tianyu; Shao, Yiping

    2008-08-01

    This work is part of a feasibility study to develop SPECT imaging capability on a lutetium oxyorthosilicate (LSO) based animal PET system. The SPECT acquisition was enabled by inserting a collimator assembly inside the detector ring and acquiring data in singles mode. The same LSO detectors were used for both PET and SPECT imaging. The intrinsic radioactivity of 176Lu in the LSO crystals, however, contaminates the SPECT data, and can generate image artifacts and introduce quantification error. The objectives of this study were to evaluate the effectiveness of a LSO background subtraction method, and to estimate the minimal detectable target activity (MDTA) of image object for SPECT imaging. For LSO background correction, the LSO contribution in an image study was estimated based on a pre-measured long LSO background scan and subtracted prior to the image reconstruction. The MDTA was estimated in two ways. The empirical MDTA (eMDTA) was estimated from screening the tomographic images at different activity levels. The calculated MDTA (cMDTA) was estimated from using a formula based on applying a modified Currie equation on an average projection dataset. Two simulated and two experimental phantoms with different object activity distributions and levels were used in this study. The results showed that LSO background adds concentric ring artifacts to the reconstructed image, and the simple subtraction method can effectively remove these artifacts—the effect of the correction was more visible when the object activity level was near or above the eMDTA. For the four phantoms studied, the cMDTA was consistently about five times of the corresponding eMDTA. In summary, we implemented a simple LSO background subtraction method and demonstrated its effectiveness. The projection-based calculation formula yielded MDTA results that closely correlate with that obtained empirically and may have predicative value for imaging applications.

  6. Lutetium ultraphosphate.

    PubMed

    Horchani-Naifer, Karima; Férid, Mokhtar

    2008-05-10

    The structure of the title compound, LuP(5)O(14), comprises puckered eight-membered PO(4) rings linked by the lutetium cations in a complex way, forming a three-dimensional framework. Each eight-membered phosphate ring shares a bridging tetra-hedron with each of four adjacent tetra-hedra, to form layers of PO(4) tetra-hedra. These layers are c/2 in thickness and parallel to the ab plane. Each Lu ion is contained in one such layer, forming bonds to six O atoms in that layer and also to one O atom belonging to a tetra-hedron in each of the layers lying above and below it. The LuO(8) polyhedra are isolated from one another, since they share no common atoms. The Lu ions lie on twofold axes (special position 4e) and the shortest Lu⋯Lu distance is 5.703 (1) Å.

  7. Selective photoionisation of lutetium isotopes

    SciTech Connect

    D'yachkov, Aleksei B; Kovalevich, S K; Labozin, Valerii P; Mironov, Sergei M; Panchenko, Vladislav Ya; Firsov, Valerii A; Tsvetkov, G O; Shatalova, G G

    2012-10-31

    A three-stage laser photoionisation scheme intended for enriching the {sup 176}Lu isotope from natural lutetium was considered. An investigation was made of the hyperfine structure of the second excited state 5d6s7s {yields} {sup 4}D{sub 3/2} with an energy of 37194 cm{sup -1} and the autoionisation state with an energy of 53375 cm{sup -1} of the {sup 176}Lu and {sup 175}Lu isotopes. The total electron momentum of the autoionisation level and the constant A of hyperfine magnetic interaction were determined. Due to a small value of the isotopic shift between {sup 176}Lu and {sup 175}Lu, appreciable selectivity of their separation may be achieved with individual hyperfine structure components. The first tentative enrichment of the 176Lu isotope was performed to a concentration of 60 % - 70 %. (laser applications and other topics in quantum electronics)

  8. Lutetium ultraphosphate

    PubMed Central

    Horchani-Naifer, Karima; Férid, Mokhtar

    2008-01-01

    The structure of the title compound, LuP5O14, comprises puckered eight-membered PO4 rings linked by the lutetium cations in a complex way, forming a three-dimensional framework. Each eight-membered phosphate ring shares a bridging tetra­hedron with each of four adjacent tetra­hedra, to form layers of PO4 tetra­hedra. These layers are c/2 in thickness and parallel to the ab plane. Each Lu ion is contained in one such layer, forming bonds to six O atoms in that layer and also to one O atom belonging to a tetra­hedron in each of the layers lying above and below it. The LuO8 polyhedra are isolated from one another, since they share no common atoms. The Lu ions lie on twofold axes (special position 4e) and the shortest Lu⋯Lu distance is 5.703 (1) Å. PMID:21202435

  9. Calibration of the lutetium-hafnium clock.

    PubMed

    Scherer, E; Munker, C; Mezger, K

    2001-07-27

    Well-defined constants of radioactive decay are the cornerstone of geochronology and the use of radiogenic isotopes to constrain the time scales and mechanisms of planetary differentiation. Four new determinations of the lutetium-176 decay constant (lambda176Lu) made by calibration against the uranium-lead decay schemes yield a mean value of 1.865 +/- 0.015 x 10(-11) year(-1), in agreement with the two most recent decay-counting experiments. Lutetium-hafnium ages that are based on the previously used lambda176Lu of 1.93 x 10(-11) to 1.94 x 10(-11) year(-1) are thus approximately 4% too young, and the initial hafnium isotope compositions of some of Earth's oldest minerals and rocks become less radiogenic relative to bulk undifferentiated Earth when calculated using the new decay constant. The existence of strongly unradiogenic hafnium in Early Archean and Hadean zircons implies that enriched crustal reservoirs existed on Earth by 4.3 billion years ago and persisted for 200 million years or more. Hence, current models of early terrestrial differentiation need revision.

  10. Fermi surface measurements of lutetium

    NASA Astrophysics Data System (ADS)

    Johanson, W. R.; Crabtree, G. W.; Schmidt, F. A.

    1982-03-01

    We report de Haas-van Alphen (dHvA) measurements of the Fermi surface of lutetium at temperatures down to 0.3 K and in fields up to 150 kG in the (101¯0) and (112¯0) planes. Lutetium, having a filled 4f shell, serves as a nonmagnetic prototype of the structurally similar (hcp), trivalent, heavy rare earths from Gd to Tm. No complete frequency branches were observed, indicating that there are no closed pieces of surface. We observed all but one orbit predicted by relativistic-augmented-plane wave (RAPW) calculations of Keeton and Loucks, and the data support a geometry that is in good qualitative agreement with the existence of nested open electron and hole sheets.

  11. Fermi surface measurements of lutetium

    SciTech Connect

    Johanson, W.R.; Crabtree, G.W.; Schmidt, F.A.

    1982-03-01

    We report de Haas-van Alphen (dHvA) measurements of the Fermi surface of lutetium at temperatures down to 0.3 K and in fields up to 150 kG in the (1010) and (1120) planes. Lutetium, having a filled 4f shell, serves as a nonmagnetic prototype of the structurally similar (hcp), trivalent, heavy rare earths from Gd to Tm. No complete frequency branches were observed, indicating that there are no closed pieces of surface. We observed all but one orbit predicted by relativistic-augmented-plane wave (RAPW) calculations of Keeton and Loucks, and the data support a geometry that is in good qualitative agreement with the existence of nested open electron and hole sheets.

  12. Fermi surface measurements of lutetium

    SciTech Connect

    Johanson, W.R.; Crabtree, G.W.; Schmidt, F.A.

    1982-01-01

    We report de Haas-van Alphen (dHvA) measurements of the Fermi surface of Lutetium at temperatures down to .3K and in fields up to 150 kG in the (1010) and (1120) planes. Lutetium, having a filled 4f shell, serves as a non-magnetic prototype of the structurally similar (hcp), trivalent, heavy rare-earths from Gd to Tm. No complete frequency branches were observed, indicating that there are no closed pieces of surface. We observed all but one orbit predicted by relativistic-augmented-plane wave (RAPW) calculations of Keeton and Loucks, and the data support a geometry that is in good qualitative agreement with the existence of nested open electron and hole sheets.

  13. Synthesis and evaluation of bombesin derivatives on the basis of pan-bombesin peptides labeled with indium-111, lutetium-177, and yttrium-90 for targeting bombesin receptor-expressing tumors.

    PubMed

    Zhang, Hanwen; Chen, Jianhua; Waldherr, Christian; Hinni, Karin; Waser, Beatrice; Reubi, Jean Claude; Maecke, Helmut R

    2004-09-15

    Bombesin receptors are overexpressed on a variety of human tumors like prostate, breast, and lung cancer. The aim of this study was to develop radiolabeled (Indium-111, Lutetium-177, and Yttrium-90) bombesin analogues with affinity to the three bombesin receptor subtypes for targeted radiotherapy. The following structures were synthesized: diethylenetriaminepentaacetic acid-gamma-aminobutyric acid-[D-Tyr6, beta-Ala11, Thi13, Nle14] bombesin (6-14) (BZH1) and 1,4,7,10-tetraazacyclododecane-N,N',N",N"' -tetraacetic acid-gamma-aminobutyric acid-[D-Tyr6, beta-Ala11, Thi13, Nle14] bombesin (6-14) (BZH2). [111In]-BZH1 and in particular [90Y]-BZH2 were shown to have high affinity to all three human bombesin receptor subtypes with binding affinities in the nanomolar range. In human serum metabolic cleavage was found between beta-Ala11 and His12 with an approximate half-life of 2 hours. The metabolic breakdown was inhibited by EDTA and beta-Ala11-His12 (carnosine) indicating that carnosinase is the active enzyme. Both 111In-labeled peptides were shown to internalize into gastrin-releasing peptide-receptor-positive AR4-2J and PC-3 cells with similar high rates, which were independent of the radiometal. The biodistribution studies of [111In]-BZH1 and [111In]-BZH2 ([177Lu]-BZH2) in AR4-2J tumor-bearing rats showed specific and high uptake in gastrin-releasing peptide-receptor-positive organs and in the AR4-2J tumor. A fast clearance from blood and all of the nontarget organs except the kidneys was found. These radiopeptides were composed of the first pan-bombesin radioligands, which show great promise for the early diagnosis of tumors bearing not only gastrin-releasing peptide-receptors but also the other two bombesin receptor subtypes and may be of use in targeted radiotherapy of these tumors.

  14. Absolute peptide quantification by lutetium labeling and nanoHPLC-ICPMS with isotope dilution analysis.

    PubMed

    Rappel, Christina; Schaumlöffel, Dirk

    2009-01-01

    The need of analytical methods for absolute quantitative protein analysis spurred research on new developments in recent years. In this work, a novel approach was developed for accurate absolute peptide quantification based on metal labeling with lutetium diethylenetriamine pentaacetic acid (Lu-DTPA) and nanoflow high-performance liquid chromatography-inductively coupled plasma isotope dilution mass spectrometry (nanoHPLC-ICP-IDMS). In a two-step procedure peptides were derivatized at amino groups with diethylenetriamine pentaacetic anhydride (DTPAA) followed by chelation of lutetium. Electrospray ionization mass spectrometry (ESI MS) of the reaction product demonstrated highly specific peptide labeling. Under optimized nanoHPLC conditions the labeled peptides were baseline-separated, and the excess labeling reagent did not interfere. A 176Lu-labeled spike was continuously added to the column effluent for quantification by ICP-IDMS. The recovery of a Lu-DTPA-labeled standard peptide was close to 100% indicating high labeling efficiency and accurate absolute quantification. The precision of the entire method was 4.9%. The detection limit for Lu-DTPA-tagged peptides was 179 amol demonstrating that lutetium-specific peptide quantification was by 4 orders of magnitude more sensitive than detection by natural sulfur atoms present in cysteine or methionine residues. Furthermore, the application to peptides in insulin tryptic digest allowed the identification of interfering reagents decreasing the labeling efficiency. An additional advantage of this novel approach is the analysis of peptides, which do not naturally feature ICPMS-detectable elements.

  15. Synthesis of Lutetium Phosphate/Apoferritin Core-Shell Nanoparticles for Potential Applications in Radioimmunoimaging and Radioimmunotherapy of Cancers

    SciTech Connect

    Wu, Hong; Engelhard, Mark H.; Wang, Jun; Fisher, Darrell R.; Lin, Yuehe

    2008-04-01

    We report a novel approach for synthesizing LuPO4/apoferritin core-shell nanoparticles based on an apoferritin template, conjugated to the protein biotin. To prepare the nanoparticle conjugates, we used non-radioactive lutetium as a model target or surrogate for radiolutetium (177Lu). The central cavity, multi-channel structure, and chemical properties of apoferritin are well-suited for sequentially diffusing lutetium and phosphate ions into the cavity--resulting in a stable core-shell composite. We characterized the synthesized LuPO4/apoferritin nanoparticle using transmission electron microscopy (TEM) and x-ray photoelectron spectroscopy (XPS). We tested the pre-targeting capability of biotin-modified lutetium/apoferritin nanoparticle using streptavidin-modified magnetic beads and streptavidin-modified fluorescein isothiocyanate (FITC) tracer. This paper presents a simple, fast, and efficient method for synthesizing LuPO4/apoferritin nanoparticle conjugates with biotin for potential applications in radioimmunotherapy and radioimmunoimaging of cancer.

  16. Heteroleptic naphthalo-phthalocyaninates of lutetium: synthesis and spectral and conductivity properties.

    PubMed

    Dubinina, Tatiana V; Kosov, Anton D; Petrusevich, Elizaveta F; Maklakov, Sergey S; Borisova, Nataliya E; Tomilova, Larisa G; Zefirov, Nikolay S

    2015-05-07

    Novel heteroleptic naphthalo-phthalocyaninates of lutetium possessing a symmetrical substituted naphthalocyanine deck were synthesized on the basis of two preformed synthetic blocks: naphthalocyanine ligand and lutetium phthalocyaninates. The compounds obtained were characterized by (1)H NMR and high-resolution MALDI-TOF/TOF mass spectrometry. The correlation between the nature of the substituents and the spectral properties of the target complexes was determined by the introduction of electron-donating (aryl-, aryloxy-) or electron-withdrawing (chloro-) substituents into the phthalocyanine deck. In addition, the nature of peripheral substituents was shown not to affect drastically the phthalocyanine conductivity and activation energy. Conductivity properties depend on thin film morphology which, in turn, relies on intermolecular π-π interactions.

  17. Lutetium oxide-based transparent ceramic scintillators

    DOEpatents

    Seeley, Zachary; Cherepy, Nerine; Kuntz, Joshua; Payne, Stephen A.

    2016-01-19

    In one embodiment, a transparent ceramic of sintered nanoparticles includes gadolinium lutetium oxide doped with europium having a chemical composition (Lu.sub.1-xGd.sub.x).sub.2-YEu.sub.YO.sub.3, where X is any value within a range from about 0.05 to about 0.45 and Y is any value within a range from about 0.01 to about 0.2, and where the transparent ceramic exhibits a transparency characterized by a scatter coefficient of less than about 10%/cm. In another embodiment, a transparent ceramic scintillator of sintered nanoparticles, includes a body of sintered nanoparticles including gadolinium lutetium oxide doped with a rare earth activator (RE) having a chemical composition (Lu.sub.1-xGd.sub.x).sub.2-YRE.sub.YO.sub.3, where RE is selected from the group consisting of: Sm, Eu, Tb, and Dy, where the transparent ceramic exhibits a transparency characterized by a scatter coefficient of less than about 10%/cm.

  18. 49 CFR 176.176 - Signals.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Class 1 (Explosive) Materials Handling Class 1 (explosive) Materials in Port § 176.176 Signals. When Class 1 (explosive) materials are being loaded, handled, or unloaded on a vessel, the vessel must... Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY...

  19. Theranostic Applications of Lutetium-177 in Radionuclide Therapy.

    PubMed

    Das, Tapas; Banerjee, Sharmila

    2016-01-01

    Lutetium-177 has been widely discussed as a radioisotope of choice for targeted radionuclide therapy. The simultaneous emission of imageable gamma photons [208 keV (11%) and 113 keV (6.4%)] along with particulate β(-) emission [β(max) = 497 keV] makes it a theranostically desirable radioisotope. In the present article, the possibility of using two 177Lu-based agents viz. 177Lu-EDTMP and 177Lu-DOTATATE for theranostic applications in metastatic bone pain palliation (MBPP) and peptide receptor radionuclide therapy (PRRT), have been explored. In the case of 177Lu-EDTMP, the whole-body images obtained are compared with those recorded using 99mTc-MDP in the same patient. On the other hand, pre-therapy images acquired with 177Lu-DOTA-TATE are compared with similar images obtained with standard agents, such as 99mTc-HYNIC-TOC (SPECT) and 68Ga-DOTA-TOC (PET) in the same patient. The advantage of the long physical half-life (T1/2) of 177Lu has been utilized in mapping the pharmacokinetics of two additional agents, 177Lu-labeled hydroxyapatite (HA) in radiation synovectomy of knee joints and 177Lu-HA for therapy of hepatocellular carcinoma. Results of these multiple studies conclusively document the potential of 177Lu as a theranostic radioisotope.

  20. Static and Dynamical Properties of heavy actinide Monopnictides of Lutetium.

    PubMed

    Mir, Showkat H; Jha, Prakash C; Islam, M S; Banarjee, Amitava; Luo, Wei; Dabhi, Shweta D; Jha, Prafulla K; Ahuja, R

    2016-07-07

    In this work, density functional theory within the framework of generalized gradient approximation has been used to investigate the structural, elastic, mechanical, and phonon properties of lutetium monopnictides in rock-salt crystal structure. The spin orbit coupling and Hubbard-U corrections are included to correctly predict the essential properties of these compounds. The elastic constants, Young's modulus E, Poisson's ratio v, shear modulus G, anisotropy factor A and Pugh's ratio are computed. We found that all lutetium monopnictides are anisotropic and show brittle character. From the wave velocities along [100], [110] and [111] directions, melting temperature of lutetium monopnictides are predicted. Dynamical stability of these monopnictides has been studied by density functional perturbation theory.

  1. Static and Dynamical Properties of heavy actinide Monopnictides of Lutetium

    PubMed Central

    Mir, Showkat H.; Jha, Prakash C.; Islam, M. S.; Banarjee, Amitava; Luo, Wei; Dabhi, Shweta D.; Jha, Prafulla K.; Ahuja, R.

    2016-01-01

    In this work, density functional theory within the framework of generalized gradient approximation has been used to investigate the structural, elastic, mechanical, and phonon properties of lutetium monopnictides in rock-salt crystal structure. The spin orbit coupling and Hubbard-U corrections are included to correctly predict the essential properties of these compounds. The elastic constants, Young’s modulus E, Poisson’s ratio v, shear modulus G, anisotropy factor A and Pugh’s ratio are computed. We found that all lutetium monopnictides are anisotropic and show brittle character. From the wave velocities along [100], [110] and [111] directions, melting temperature of lutetium monopnictides are predicted. Dynamical stability of these monopnictides has been studied by density functional perturbation theory. PMID:27384709

  2. Hydrothermal synthesis of lutetium disilicate nanoparticles

    SciTech Connect

    Tang Xiaoping; Gao Yanfeng; Chen Hongfei; Luo Hongjie

    2012-04-15

    A simple, low-cost hydrothermal method was developed to synthesize irregular-and rod-shaped lutetium disilicate (Lu{sub 2}Si{sub 2}O{sub 7}) powders with sizes ranging from 71 to 340 nm. The synthesis temperature was 260 Degree-Sign C, which is nearly 1300 Degree-Sign C lower than that required for the solid-state reaction. The results indicated that both the hydrothermal temperature and pH values had great influences on the composition, crystalline phase and morphology of the powders. The formation mechanism, basic thermophysical properties, stability and anticorrosion properties of the Lu{sub 2}Si{sub 2}O{sub 7} powders were also investigated. The obtained powders possessed low thermal conductivity, a suitable thermal expansion coefficient (3.92-5.17 Multiplication-Sign 10{sup -6} K{sup -1}) with the silicon-based substrate and excellent thermal and structural stability. During hot corrosion testing, the surfaces of the samples appeared to react with the water and molten salt vapors, but no serious failure occurred. - Graphical abstract: An image for the as-prepared Lu{sub 2}Si{sub 2}O{sub 7} powders (left) and XRD pattern (right) (inset shows the SEM graph of powders). Highlights: Black-Right-Pointing-Pointer We synthesized Lu{sub 2}Si{sub 2}O{sub 7} powders via a hydrothermal process at 260 Degree-Sign C. Black-Right-Pointing-Pointer Crystalline phase and morphology of the powders changed with experimental parameter. Black-Right-Pointing-Pointer Hot corrosion was determined in an airflow environment containing alkaline vapor.

  3. Discovery of gallium, germanium, lutetium, and hafnium isotopes

    SciTech Connect

    Gross, J.L.; Thoennessen, M.

    2012-09-15

    Currently, twenty-eight gallium, thirty-one germanium, thirty-five lutetium, and thirty-six hafnium isotopes have been observed and the discovery of these isotopes is described here. For each isotope a brief synopsis of the first refereed publication, including the production and identification method, is presented.

  4. Lutetium-177 Labeled Bombesin Peptides for Radionuclide Therapy.

    PubMed

    Reynolds, Tamila Stott; Bandari, Rajendra P; Jiang, Zongrun; Smith, Charles J

    2016-01-01

    The rare-earth radionuclides that decay by beta particle (β-) emission are considered to be ideal in the context of targeted radiotherapy. The rare-earth isotopes exist primarily in the 3+ oxidation state and are considered to be hard metal centers, requiring multidentate, hard donor ligands such as the poly(aminocarboxylates) for in vivo kinetic inertness. 177Lu is a rare-earth radionuclide that is produced in moderate specific activity (740 GBq/mg) by direct neutron capture of enriched 176Lu via the 176Lu(n,γ)177Lu nuclear reaction. 177Lu has a half-life of 6.71 d, decays by beta emission (Ebmax = 0.497 MeV), and emits two imagable photons (113keV, 3% and 208kev, 11%). High specific activity, no-carrier-added 177Lu can also be prepared by an indirect neutron capture nuclear reaction on a 176Yb target. Herein, we report upon bombesin (BBN) peptides radiolabeled with 177Lu. The impetus driving many of the research studies that we have described in this review is that the high-affinity gastrin releasing peptide receptor (GRPR, BBN receptor subtype 2, BB2) has been identified in tissue biopsy samples and immortalized cell lines of many human cancers and is an ideal biomarker for targeting early-stage disease. Early on, the ability of GRPR agonists to be rapidly internalized coupled with a high incidence of GRPR expression on various neoplasias was a driving force for the design and development of new diagnostic and therapeutic agents targeting GRP receptor-positive tumors. Recent reports, however, show compelling evidence that radiopharmaceutical design and development based upon antagonist-type ligand frameworks clearly bears reexamination. Last of all, the ability to target multiple biomarkers simultaneously via a heterodimeric targeting ligand has also provided a new avenue to investigate the dual targeting capacity of bivalent radioligands for improved in vivo molecular imaging and treatment of specific human cancers. In this report, we describe recent advances

  5. 49 CFR 176.122-176.124 - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 2 2013-10-01 2013-10-01 false 176.122-176.124 Section 176.122-176.124 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS REGULATIONS CARRIAGE BY VESSEL Detailed Requirements for Class 1 (Explosive) Materials...

  6. 49 CFR 176.128-176.136 - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 2 2013-10-01 2013-10-01 false 176.128-176.136 Section 176.128-176.136 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS REGULATIONS CARRIAGE BY VESSEL Detailed Requirements for Class 1 (Explosive) Materials...

  7. 46 CFR 176.2-176.99 - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false 176.2-176.99 Section 176.2-176.99 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) INSPECTION AND CERTIFICATION General Provisions; Certificate of Inspection §§...

  8. 49 CFR 176.122-176.124 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false 176.122-176.124 Section 176.122-176.124 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS REGULATIONS CARRIAGE BY VESSEL Detailed Requirements for Class 1 (Explosive) Materials...

  9. Optical Response of Shocked Cerium-Doped Lutetium Oxyorthosilicate

    SciTech Connect

    G. D. Stevens

    2003-03-01

    Shock experiments were performed in order to characterize the triboluminescent signature of cerium-doped lutetium oxyorthosilicate (LSO:Ce). This material shows prompt, nano-second timescale light emission when driven by explosive detonation. When properly applied to a surface, it may be used as a shock arrival sensor, and also for imaging the propagation of a shock front. Triboluminescent rise times, spectral content, and spatial resolution measurements are presented.

  10. Parameters for the RM1 Quantum Chemical Calculation of Complexes of the Trications of Thulium, Ytterbium and Lutetium.

    PubMed

    Filho, Manoel A M; Dutra, José Diogo L; Rocha, Gerd B; Simas, Alfredo M; Freire, Ricardo O

    2016-01-01

    The RM1 quantum chemical model for the calculation of complexes of Tm(III), Yb(III) and Lu(III) is advanced. Subsequently, we tested the models by fully optimizing the geometries of 126 complexes. We then compared the optimized structures with known crystallographic ones from the Cambridge Structural Database. Results indicate that, for thulium complexes, the accuracy in terms of the distances between the lanthanide ion and its directly coordinated atoms is about 2%. Corresponding results for ytterbium and lutetium are both 3%, levels of accuracy useful for the design of lanthanide complexes, targeting their countless applications.

  11. Parameters for the RM1 Quantum Chemical Calculation of Complexes of the Trications of Thulium, Ytterbium and Lutetium

    PubMed Central

    Filho, Manoel A. M.; Dutra, José Diogo L.; Rocha, Gerd B.; Simas, Alfredo M.

    2016-01-01

    The RM1 quantum chemical model for the calculation of complexes of Tm(III), Yb(III) and Lu(III) is advanced. Subsequently, we tested the models by fully optimizing the geometries of 126 complexes. We then compared the optimized structures with known crystallographic ones from the Cambridge Structural Database. Results indicate that, for thulium complexes, the accuracy in terms of the distances between the lanthanide ion and its directly coordinated atoms is about 2%. Corresponding results for ytterbium and lutetium are both 3%, levels of accuracy useful for the design of lanthanide complexes, targeting their countless applications. PMID:27223475

  12. Evolving Important Role of Lutetium-177 for Therapeutic Nuclear Medicine.

    PubMed

    Pillai, Ambikalmajan M R; Knapp, Furn F Russ

    2015-01-01

    Lutetium-177 ((177)Lu) is a late entrant into the nuclear medicine therapy arena but is expected to become one of the most widely used therapeutic radionuclides. This paper analyses the reason for the increasing preference of (177)Lu as a therapeutic radionuclide. While the radionuclidic properties favor its use for several therapeutic applications, the potential for large scale production of (177)Lu is also an important aspect for its acceptability as a therapeutic radionuclide. This introductory discussion also summarizes some developing clinical uses and suggested future directions for applications of (177)Lu.

  13. Enhancement of lutetium texaphyrin phototherapy with Mitomycin C

    NASA Astrophysics Data System (ADS)

    Thiemann, Patricia A.; Woodburn, Kathryn W.

    1998-05-01

    Lutetium texaphyrin (Lu-Tex) photodynamic therapy (PDT) relies on the presence of the water-soluble Lu-Tex, oxygen, and light (activation around 730 nm). Cytotoxic oxygen species are produced that cause irreversible damage to biological substrates. Damage may be inflicted via direct cell kill mechanisms or through vasculature effects that cause hypoxia. The addition of hypoxia enhanced drugs, such as Mitomycin C (MMC), can potentially increase the anti-tumor response. RIF-1 bearing C3H mice received 10 micrometers ol Lu-Tex/kg and were illuminated with 100 J/cm2 3 hours postinjection. Mice received MMC (2.5 or 5 mg/kg, before and after light) in conjunction with PDT and were compared to subsets of drug alone controls. A significant improvement in PDT response was observed when MMC was added to the dosing regimen; the effect was more pronounced at the highest MMC dose of 5 mg/kg: MMC prior to PDT gave a median tumor regrowth time (10X original volume) of 28 days compared to MMC and PDT alone, 16.3 and 14.9 days, respectively. The anti-tumor activity of lutetium texaphyrin induced PDT was improved by the addition of the bioreductive alkylating agent mitomycin C.

  14. Electrochromic cells with lutetium diphthalocyanine and semisolid polymer electrolytes

    NASA Astrophysics Data System (ADS)

    Pizzarello, F. A.; Nicholson, M. M.

    1987-11-01

    Cyclic voltammograms were obtained for lutetium diphthalocyanine films in contact with plasticized poly(ethylene oxide) (PEO) electrolytes or solvent-swollen 2-acrylamido-2-methylpropane- sulfonic acid (AMPS) polymer electrolytes. Cells containing PEO-salt combinations plasticized with propylene glycol (PG) or acetonitrile resulted in slow, nonuniform color changes due to high interfacial resistance. The AMPS cell fabrication was simplified by starting with a commercial AMPS polymer product in the form of a transparent sheet containing water and other additives. This material, when further swollen in a PG-HC1 solution, produced the full range of uniform colors, accompanied by well defined voltammograms. It maintained good contact with the dye from -5 to 40 C.

  15. Lutetium-methanediide-alkyl complexes: synthesis and chemistry.

    PubMed

    Li, Shihui; Wang, Meiyan; Liu, Bo; Li, Lei; Cheng, Jianhua; Wu, Chunji; Liu, Dongtao; Liu, Jingyao; Cui, Dongmei

    2014-11-17

    The first four-coordinate methanediide/alkyl lutetium complex (BODDI)Lu2 (CH2 SiMe3 )2 (μ2 -CHSiMe3 )(THF)2 (BODDI=ArNC(Me)CHCOCHC(Me)NAr, Ar=2,6-iPr2 C6 H3 ) (1) was synthesized by a thermolysis methodology through α-H abstraction from a Lu-CH2 SiMe3 group. Complex 1 reacted with equimolar 2,6-iPrC6 H3 NH2 and Ph2 C+O to give the corresponding lutetium bridging imido and oxo complexes (BODDI)Lu2 (CH2 SiMe3 )2 (μ2 -N-2,6-iPr2 C6 H3 )(THF)2 (2) and (BODDI)Lu2 (CH2 SiMe3 )2 (μ2 -O)(THF)2 (3). Treatment of 3 with Ph2 C=O (4 equiv) caused a rare insertion of Lu-μ2 -O bond into theC=O group to afford a diphenylmethyl diolate complex 4. Reaction of 1 with PhN=C=O (2 equiv) led to the migration of SiMe3 to the amido nitrogen atom to give complex (BODDI)Lu2 (CH2 SiMe3 )2 -μ-{PhNC(O)CHC(O)NPh(SiMe3 )-κ(3) N,O,O}(THF) (5). Reaction of 1 withtBuN=C formed an unprecedented product (BODDI)Lu2 (CH2 SiMe3 ){μ2 -[η(2) :η(2) -tBuN=C(=CH2 )SiMe2 CHC=NtBu-κ(1) N]}(tBuN=C)2 (6) through a cascade reaction of N=C bond insertion, sequential cyclometalative γ-(sp(3) )-H activation, C=C bond formation, and rearrangement of the newly formed carbene intermediate. The possible mechanistic pathways between 1, PhN=C=O, and tBuN=C were elucidated by DFT calculations.

  16. On the use of X-ray absorption spectroscopy to elucidate the structure of lutetium adenosine mono- and triphosphate complexes.

    PubMed

    Mostapha, S; Berthon, C; Fontaine-Vive, F; Gaysinski, M; Guérin, L; Guillaumont, D; Massi, L; Monfardini, I; Solari, P L; Thomas, O P; Charbonnel, M C; Den Auwer, C

    2014-02-01

    Although the physiological impact of the actinide elements as nuclear toxicants has been widely investigated for half a century, a description of their interactions with biological molecules remains limited. It is however of primary importance to better assess the determinants of actinide speciation in cells and more generally in living organisms to unravel the molecular processes underlying actinide transport and deposition in tissues. The biological pathways of this family of elements in case of accidental contamination or chronic natural exposure (in the case of uranium rich soils for instance) are therefore a crucial issue of public health and of societal impact. Because of the high chemical affinity of those actinide elements for phosphate groups and the ubiquity of such chemical functions in biochemistry, phosphate derivatives are considered as probable targets of these cations. Among them, nucleotides and in particular adenosine mono- (AMP) and triphosphate (ATP) nucleotides occur in more chemical reactions than any other compounds on the earth's surface, except water, and are therefore critical target molecules. In the present study, we are interested in trans-plutonium actinide elements, in particular americium and curium that are more rarely considered in environmental and bioaccumulation studies than early actinides like uranium, neptunium and plutonium. A first step in this strategy is to work with chemical analogues like lanthanides that are not radioactive and therefore allow extended physical chemical characterization to be conducted that are difficult to perform with radioactive materials. We describe herein the interaction of lutetium(III) with adenosine AMP and ATP. With AMP and ATP, insoluble amorphous compounds have been obtained with molar ratios of 1:2 and 1:1, respectively. With an excess of ATP, with 1:2 molar ratio, a soluble complex has been obtained. A combination of spectroscopic techniques (IR, NMR, ESI-MS, EXAFS) together with quantum

  17. Synthesis and densification of lutetium pyrosilicate from lutetia and silica

    SciTech Connect

    Tripathi, Himansu S.; Sarin, Vinod K. . E-mail: sarin@bu.edu

    2007-02-15

    Cerium-doped lutetium pyrosilicate (Lu{sub 2}Si{sub 2}O{sub 7}:Ce) powder was synthesized by solid state reaction of Lu{sub 2}O{sub 3} and SiO{sub 2}. Stoichiometric mixtures of the starting materials were heat treated at various different temperatures and their phase contents were measured by XRD technique. It was found that the first step in the formation of Lu{sub 2}Si{sub 2}O{sub 7} (LPS) is the appearance of Lu{sub 2}SiO{sub 5} (LSO). This takes place at 1100 deg. C, fully 300 deg. C below the first appearance of LPS. Between 1400 and 1500 deg. C both LSO and LPS coexist in the calcined batch, but by 1550 deg. C all LSO is completely converted to LPS. LPS formation temperature does not have appreciable effect on the density of the hot pressed samples. Hot pressed samples obtained from powder synthesized at 1650 deg. C are nearly transparent, although the particle size of the starting powder is higher than that of the powder formed at lower temperatures.

  18. A cascade reaction: ring-opening insertion of dioxaphospholane into lutetium alkyl bonds.

    PubMed

    Johnson, Kevin R D; Hayes, Paul G

    2014-02-14

    Geometrically constrained dioxaphospholane rings were incorporated into a bis(phosphinimine)carbazole ligand (HL) in an effort to generate an ancillary ligand system that is capable of supporting reactive lutetium alkyl functionalities and resistant to cyclometalation reactivity. This new ligand was used to prepare a lutetium dialkyl species, LLu(CH2SiMe3)2; however, the complex exhibited low thermal stability at ambient temperature. This dialkyl compound was found to be highly susceptible to a cascading inter- and intramolecular reaction that resulted in the sole formation of an asymmetric bimetallic tetraalkoxide complex. The product of this reaction, generated by the ring-opening insertion of dioxaphospholane moieties into lutetium-carbon bonds, was characterized by multinuclear NMR spectroscopy and single crystal X-ray diffraction.

  19. Magneto-optical property of terbium-lutetium-aluminum garnet crystals

    NASA Astrophysics Data System (ADS)

    Man, Peiwen; Ma, Fengkai; Xie, Tao; Ding, Jingxin; Wu, Anhua; Su, Liangbi; Li, Huanying; Ren, Guohao

    2017-04-01

    Mixed terbium lutetium aluminum garnet Tb2.2Lu0.8Al5O12 (LuTAG) single crystal was grown by Czochralski technique successfully. The structure had been analyzed by X-ray diffraction. The paramagnetic behavior was observed in magnetic measurement. Magneto-optical properties and thermal conductivity of LuTAG had been studied in detail and compared with these of TGG sample. The crystal exhibited a high thermal conductivity and very high transmittance, particularly in visible and near-infrared region, indicating terbium-lutetium-aluminum garnet could be a potential magneto-optical material using in high-power laser system.

  20. Lutetium-doped EuO films grown by molecular-beam epitaxy

    SciTech Connect

    Melville, A.; Heeg, T.; Mairoser, T.; Schmehl, A.; Shai, D. E.; Monkman, E. J.; Harter, J. W.; Hollaender, B.; Schubert, J.; Shen, K. M.; Mannhart, J.; Schlom, D. G.

    2012-05-28

    The effect of lutetium doping on the structural, electronic, and magnetic properties of epitaxial EuO thin films grown by reactive molecular-beam epitaxy is experimentally investigated. The behavior of Lu-doped EuO is contrasted with doping by lanthanum and gadolinium. All three dopants are found to behave similarly despite differences in electronic configuration and ionic size. Andreev reflection measurements on Lu-doped EuO reveal a spin-polarization of 96% in the conduction band, despite non-magnetic carriers introduced by 5% lutetium doping.

  1. Novel lutetium spectroscopic interactions via cw RIMS (Resonance Ionization Mass Spectrometry)

    SciTech Connect

    Fearey, B.L.; Miller, C.M.

    1989-01-01

    Novel spectroscopic interactions of argon-ion laser enhanced resonance ionization of lutetium are observed and discussed; these include line-narrowing, non-linear power dependences and anomalous optical pumping effects of the hyperfine transitions. In addition, isotopically saturation dip spectra are observed and presented, allowing for precise determination of hyperfine constants of rare isotopes. 12 refs., 2 figs.

  2. Lutetium-177 DOTATATE Production with an Automated Radiopharmaceutical Synthesis System

    PubMed Central

    Aslani, Alireza; Snowdon, Graeme M; Bailey, Dale L; Schembri, Geoffrey P; Bailey, Elizabeth A; Pavlakis, Nick; Roach, Paul J

    2015-01-01

    Objective(s): Peptide Receptor Radionuclide Therapy (PRRT) with yttrium-90 (90Y) and lutetium-177 (177Lu)-labelled SST analogues are now therapy option for patients who have failed to respond to conventional medical therapy. In-house production with automated PRRT synthesis systems have clear advantages over manual methods resulting in increasing use in hospital-based radiopharmacies. We report on our one year experience with an automated radiopharmaceutical synthesis system. Methods: All syntheses were carried out using the Eckert & Ziegler Eurotope’s Modular-Lab Pharm Tracer® automated synthesis system. All materials and methods used were followed as instructed by the manufacturer of the system (Eckert & Ziegler Eurotope, Berlin, Germany). Sterile, GMP-certified, no-carrier added (NCA) 177Lu was used with GMP-certified peptide. An audit trail was also produced and saved by the system. The quality of the final product was assessed after each synthesis by ITLC-SG and HPLC methods. Results: A total of 17 [177Lu]-DOTATATE syntheses were performed between August 2013 and December 2014. The amount of radioactive [177Lu]-DOTATATE produced by each synthesis varied between 10-40 GBq and was dependant on the number of patients being treated on a given day. Thirteen individuals received a total of 37 individual treatment administrations in this period. There were no issues and failures with the system or the synthesis cassettes. The average radiochemical purity as determined by ITLC was above 99% (99.8 ± 0.05%) and the average radiochemical purity as determined by HPLC technique was above 97% (97.3 ± 1.5%) for this period. Conclusions: The automated synthesis of [177Lu]-DOTATATE using Eckert & Ziegler Eurotope’s Modular-Lab Pharm Tracer® system is a robust, convenient and high yield approach to the radiolabelling of DOTATATE peptide benefiting from the use of NCA 177Lu and almost negligible radiation exposure of the operators. PMID:27408890

  3. 2 CFR 176.130 - Noncompliance.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

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  4. 2 CFR 176.130 - Noncompliance.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Noncompliance. 176.130 Section 176.130... with § 176.120. (2) Consider requiring the removal and replacement of the unauthorized foreign iron... debarment rule implementing 2 CFR part 180. If the noncompliance appears to be fraudulent, refer the...

  5. 2 CFR 176.130 - Noncompliance.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Noncompliance. 176.130 Section 176.130... the Recovery Act in accordance with § 176.120. (2) Consider requiring the removal and replacement of... debarring official in accordance with the agency's debarment rule implementing 2 CFR part 180. If...

  6. 49 CFR 176.120 - Lightning protection.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 2 2014-10-01 2014-10-01 false Lightning protection. 176.120 Section 176.120 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY... Requirements for Class 1 (Explosive) Materials Stowage § 176.120 Lightning protection. A lightning...

  7. 49 CFR 176.120 - Lightning protection.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 2 2013-10-01 2013-10-01 false Lightning protection. 176.120 Section 176.120 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY... Requirements for Class 1 (Explosive) Materials Stowage § 176.120 Lightning protection. A lightning...

  8. 49 CFR 176.120 - Lightning protection.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 2 2011-10-01 2011-10-01 false Lightning protection. 176.120 Section 176.120 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY... Requirements for Class 1 (Explosive) Materials Stowage § 176.120 Lightning protection. A lightning...

  9. 49 CFR 176.120 - Lightning protection.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 2 2012-10-01 2012-10-01 false Lightning protection. 176.120 Section 176.120 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY... Requirements for Class 1 (Explosive) Materials Stowage § 176.120 Lightning protection. A lightning...

  10. 49 CFR 176.24 - Shipping papers.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 2 2011-10-01 2011-10-01 false Shipping papers. 176.24 Section 176.24... Requirements § 176.24 Shipping papers. (a) A person may not accept a hazardous material for transportation or transport a hazardous material by vessel unless that person has received a shipping paper prepared...

  11. 49 CFR 176.90 - Private automobiles.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Private automobiles. 176.90 Section 176.90 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY... § 176.90 Private automobiles. A private automobile which is carrying any Class 1 (explosive)...

  12. 46 CFR 160.176-11 - Performance.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 6 2010-10-01 2010-10-01 false Performance. 160.176-11 Section 160.176-11 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) EQUIPMENT, CONSTRUCTION, AND MATERIALS: SPECIFICATIONS AND APPROVAL LIFESAVING EQUIPMENT Inflatable Lifejackets § 160.176-11 Performance. (a)...

  13. 46 CFR 160.176-11 - Performance.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 6 2011-10-01 2011-10-01 false Performance. 160.176-11 Section 160.176-11 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) EQUIPMENT, CONSTRUCTION, AND MATERIALS: SPECIFICATIONS AND APPROVAL LIFESAVING EQUIPMENT Inflatable Lifejackets § 160.176-11 Performance. (a)...

  14. 46 CFR 176.810 - Fire protection.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Fire protection. 176.810 Section 176.810 Shipping COAST...) INSPECTION AND CERTIFICATION Material Inspections § 176.810 Fire protection. (a) At each initial and... and have the vessel ready for inspection of its fire protection equipment, including the following:...

  15. 46 CFR 176.810 - Fire protection.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Fire protection. 176.810 Section 176.810 Shipping COAST...) INSPECTION AND CERTIFICATION Material Inspections § 176.810 Fire protection. (a) At each initial and... and have the vessel ready for inspection of its fire protection equipment, including the following:...

  16. 2 CFR 176.130 - Noncompliance.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Noncompliance. 176.130 Section 176.130... inapplicability of section 1605 of the Recovery Act in accordance with § 176.120. (2) Consider requiring the... implementing 2 CFR part 180. If the noncompliance appears to be fraudulent, refer the matter to...

  17. 2 CFR 176.130 - Noncompliance.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Noncompliance. 176.130 Section 176.130... with § 176.120. (2) Consider requiring the removal and replacement of the unauthorized foreign iron... debarment rule implementing 2 CFR part 180. If the noncompliance appears to be fraudulent, refer the...

  18. 7 CFR 989.176 - Records.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 8 2012-01-01 2012-01-01 false Records. 989.176 Section 989.176 Agriculture... CALIFORNIA Administrative Rules and Regulations Reports and Records § 989.176 Records. Each handler shall maintain complete, accurate, and current records of all of his business affairs concerning which he...

  19. 7 CFR 989.176 - Records.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 8 2013-01-01 2013-01-01 false Records. 989.176 Section 989.176 Agriculture... CALIFORNIA Administrative Rules and Regulations Reports and Records § 989.176 Records. Each handler shall maintain complete, accurate, and current records of all of his business affairs concerning which he...

  20. 49 CFR 176.24 - Shipping papers.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 2 2013-10-01 2013-10-01 false Shipping papers. 176.24 Section 176.24... Requirements § 176.24 Shipping papers. (a) A person may not accept a hazardous material for transportation or transport a hazardous material by vessel unless that person has received a shipping paper prepared...

  1. 49 CFR 176.24 - Shipping papers.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 2 2012-10-01 2012-10-01 false Shipping papers. 176.24 Section 176.24... Requirements § 176.24 Shipping papers. (a) A person may not accept a hazardous material for transportation or transport a hazardous material by vessel unless that person has received a shipping paper prepared...

  2. 49 CFR 176.24 - Shipping papers.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 2 2014-10-01 2014-10-01 false Shipping papers. 176.24 Section 176.24... Requirements § 176.24 Shipping papers. (a) A person may not accept a hazardous material for transportation or transport a hazardous material by vessel unless that person has received a shipping paper prepared...

  3. 49 CFR 176.715 - Contamination control.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 2 2013-10-01 2013-10-01 false Contamination control. 176.715 Section 176.715 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY... Requirements for Radioactive Materials § 176.715 Contamination control. Each hold, compartment, or deck...

  4. 49 CFR 176.715 - Contamination control.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

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  5. 10 CFR 72.176 - Audits.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Audits. 72.176 Section 72.176 Energy NUCLEAR REGULATORY... RADIOACTIVE WASTE, AND REACTOR-RELATED GREATER THAN CLASS C WASTE Quality Assurance § 72.176 Audits. The... comprehensive system of planned and periodic audits to verify compliance with all aspects of the...

  6. 10 CFR 72.176 - Audits.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Audits. 72.176 Section 72.176 Energy NUCLEAR REGULATORY... RADIOACTIVE WASTE, AND REACTOR-RELATED GREATER THAN CLASS C WASTE Quality Assurance § 72.176 Audits. The... comprehensive system of planned and periodic audits to verify compliance with all aspects of the...

  7. 10 CFR 72.176 - Audits.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Audits. 72.176 Section 72.176 Energy NUCLEAR REGULATORY... RADIOACTIVE WASTE, AND REACTOR-RELATED GREATER THAN CLASS C WASTE Quality Assurance § 72.176 Audits. The... comprehensive system of planned and periodic audits to verify compliance with all aspects of the...

  8. 10 CFR 72.176 - Audits.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Audits. 72.176 Section 72.176 Energy NUCLEAR REGULATORY... RADIOACTIVE WASTE, AND REACTOR-RELATED GREATER THAN CLASS C WASTE Quality Assurance § 72.176 Audits. The... comprehensive system of planned and periodic audits to verify compliance with all aspects of the...

  9. 49 CFR 176.162 - Security.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 2 2012-10-01 2012-10-01 false Security. 176.162 Section 176.162 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION... Class 1 (Explosive) Materials Precautions During Loading and Unloading § 176.162 Security. A...

  10. 49 CFR 176.162 - Security.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Security. 176.162 Section 176.162 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION... Class 1 (Explosive) Materials Precautions During Loading and Unloading § 176.162 Security. A...

  11. 49 CFR 176.162 - Security.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 2 2014-10-01 2014-10-01 false Security. 176.162 Section 176.162 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION... Class 1 (Explosive) Materials Precautions During Loading and Unloading § 176.162 Security. A...

  12. 49 CFR 176.162 - Security.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 2 2013-10-01 2013-10-01 false Security. 176.162 Section 176.162 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION... Class 1 (Explosive) Materials Precautions During Loading and Unloading § 176.162 Security. A...

  13. 49 CFR 176.162 - Security.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 2 2011-10-01 2011-10-01 false Security. 176.162 Section 176.162 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION... Class 1 (Explosive) Materials Precautions During Loading and Unloading § 176.162 Security. A...

  14. 49 CFR 176.118 - Electrical requirement.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 2 2011-10-01 2011-10-01 false Electrical requirement. 176.118 Section 176.118... Requirements for Class 1 (Explosive) Materials Stowage § 176.118 Electrical requirement. (a) Electrical... person. (b) Electrical equipment and cables in a cargo space in which Class 1 (explosive) materials...

  15. 46 CFR 176.806 - Electrical.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Electrical. 176.806 Section 176.806 Shipping COAST GUARD... CERTIFICATION Material Inspections § 176.806 Electrical. At each initial and subsequent inspection for... ready for inspection of electrical equipment and systems, including the following: (a) Inspection of...

  16. 49 CFR 176.118 - Electrical requirement.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 2 2012-10-01 2012-10-01 false Electrical requirement. 176.118 Section 176.118... Requirements for Class 1 (Explosive) Materials Stowage § 176.118 Electrical requirement. (a) Electrical... person. (b) Electrical equipment and cables in a cargo space in which Class 1 (explosive) materials...

  17. 46 CFR 176.806 - Electrical.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Electrical. 176.806 Section 176.806 Shipping COAST GUARD... CERTIFICATION Material Inspections § 176.806 Electrical. At each initial and subsequent inspection for... ready for inspection of electrical equipment and systems, including the following: (a) Inspection of...

  18. 49 CFR 176.118 - Electrical requirement.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 2 2013-10-01 2013-10-01 false Electrical requirement. 176.118 Section 176.118... Requirements for Class 1 (Explosive) Materials Stowage § 176.118 Electrical requirement. (a) Electrical... person. (b) Electrical equipment and cables in a cargo space in which Class 1 (explosive) materials...

  19. 49 CFR 176.118 - Electrical requirement.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 2 2014-10-01 2014-10-01 false Electrical requirement. 176.118 Section 176.118... Requirements for Class 1 (Explosive) Materials Stowage § 176.118 Electrical requirement. (a) Electrical... person. (b) Electrical equipment and cables in a cargo space in which Class 1 (explosive) materials...

  20. 46 CFR 176.806 - Electrical.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Electrical. 176.806 Section 176.806 Shipping COAST GUARD... CERTIFICATION Material Inspections § 176.806 Electrical. At each initial and subsequent inspection for... ready for inspection of electrical equipment and systems, including the following: (a) Inspection of...

  1. 46 CFR 176.806 - Electrical.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Electrical. 176.806 Section 176.806 Shipping COAST GUARD... CERTIFICATION Material Inspections § 176.806 Electrical. At each initial and subsequent inspection for... ready for inspection of electrical equipment and systems, including the following: (a) Inspection of...

  2. 49 CFR 176.715 - Contamination control.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 2 2011-10-01 2011-10-01 false Contamination control. 176.715 Section 176.715... Requirements for Radioactive Materials § 176.715 Contamination control. Each hold, compartment, or deck area... the removable (non-fixed) radioactive surface contamination is not greater than the limits...

  3. 10 CFR 72.176 - Audits.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Audits. 72.176 Section 72.176 Energy NUCLEAR REGULATORY... RADIOACTIVE WASTE, AND REACTOR-RELATED GREATER THAN CLASS C WASTE Quality Assurance § 72.176 Audits. The... comprehensive system of planned and periodic audits to verify compliance with all aspects of the...

  4. 49 CFR 176.142 - Reserved

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 2 2013-10-01 2013-10-01 false Reserved] 176.142 Section 176.142 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION... Class 1 (Explosive) Materials Segregation § 176.142 Reserved]...

  5. 46 CFR 176.814 - Steering systems.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Steering systems. 176.814 Section 176.814 Shipping COAST...) INSPECTION AND CERTIFICATION Material Inspections § 176.814 Steering systems. At each initial and subsequent inspection for certification the owner or managing operator shall be prepared to test the steering systems...

  6. 7 CFR 1.76 - Department cooperation.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 1 2013-01-01 2013-01-01 false Department cooperation. 1.76 Section 1.76 Agriculture Office of the Secretary of Agriculture ADMINISTRATIVE REGULATIONS Cooperative Production of Television Films § 1.76 Department cooperation. When the producer agrees to meet the above stipulations to...

  7. 7 CFR 1.76 - Department cooperation.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Department cooperation. 1.76 Section 1.76 Agriculture Office of the Secretary of Agriculture ADMINISTRATIVE REGULATIONS Cooperative Production of Television Films § 1.76 Department cooperation. When the producer agrees to meet the above stipulations to...

  8. 7 CFR 1.76 - Department cooperation.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 1 2011-01-01 2011-01-01 false Department cooperation. 1.76 Section 1.76 Agriculture Office of the Secretary of Agriculture ADMINISTRATIVE REGULATIONS Cooperative Production of Television Films § 1.76 Department cooperation. When the producer agrees to meet the above stipulations to...

  9. 7 CFR 1.76 - Department cooperation.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 1 2014-01-01 2014-01-01 false Department cooperation. 1.76 Section 1.76 Agriculture Office of the Secretary of Agriculture ADMINISTRATIVE REGULATIONS Cooperative Production of Television Films § 1.76 Department cooperation. When the producer agrees to meet the above stipulations to...

  10. 7 CFR 1.76 - Department cooperation.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 1 2012-01-01 2012-01-01 false Department cooperation. 1.76 Section 1.76 Agriculture Office of the Secretary of Agriculture ADMINISTRATIVE REGULATIONS Cooperative Production of Television Films § 1.76 Department cooperation. When the producer agrees to meet the above stipulations to...

  11. 45 CFR 17.6 - Advance notice.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Advance notice. 17.6 Section 17.6 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION RELEASE OF ADVERSE INFORMATION TO NEWS MEDIA § 17.6 Advance notice. Any respondent or prospective respondent in an agency proceeding shall,...

  12. 45 CFR 17.6 - Advance notice.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 1 2011-10-01 2011-10-01 false Advance notice. 17.6 Section 17.6 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION RELEASE OF ADVERSE INFORMATION TO NEWS MEDIA § 17.6 Advance notice. Any respondent or prospective respondent in an agency proceeding shall,...

  13. 45 CFR 17.6 - Advance notice.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 1 2012-10-01 2012-10-01 false Advance notice. 17.6 Section 17.6 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION RELEASE OF ADVERSE INFORMATION TO NEWS MEDIA § 17.6 Advance notice. Any respondent or prospective respondent in an agency proceeding shall,...

  14. 45 CFR 17.6 - Advance notice.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 1 2013-10-01 2013-10-01 false Advance notice. 17.6 Section 17.6 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION RELEASE OF ADVERSE INFORMATION TO NEWS MEDIA § 17.6 Advance notice. Any respondent or prospective respondent in an agency proceeding shall,...

  15. 45 CFR 17.6 - Advance notice.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 1 2014-10-01 2014-10-01 false Advance notice. 17.6 Section 17.6 Public Welfare Department of Health and Human Services GENERAL ADMINISTRATION RELEASE OF ADVERSE INFORMATION TO NEWS MEDIA § 17.6 Advance notice. Any respondent or prospective respondent in an agency proceeding shall,...

  16. 46 CFR 176.1 - Preemptive effect.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Preemptive effect. 176.1 Section 176.1 Shipping COAST...) INSPECTION AND CERTIFICATION General Provisions; Certificate of Inspection § 176.1 Preemptive effect. The regulations in this part have preemptive effect over State or local regulations in the same field....

  17. 46 CFR 176.1 - Preemptive effect.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Preemptive effect. 176.1 Section 176.1 Shipping COAST...) INSPECTION AND CERTIFICATION General Provisions; Certificate of Inspection § 176.1 Preemptive effect. The regulations in this part have preemptive effect over State or local regulations in the same field....

  18. 46 CFR 176.1 - Preemptive effect.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Preemptive effect. 176.1 Section 176.1 Shipping COAST...) INSPECTION AND CERTIFICATION General Provisions; Certificate of Inspection § 176.1 Preemptive effect. The regulations in this part have preemptive effect over State or local regulations in the same field....

  19. 49 CFR 176.715 - Contamination control.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Contamination control. 176.715 Section 176.715 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY... Requirements for Radioactive Materials § 176.715 Contamination control. Each hold, compartment, or deck...

  20. 49 CFR 173.176 - Capacitors.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 2 2013-10-01 2013-10-01 false Capacitors. 173.176 Section 173.176 Transportation... PACKAGINGS Non-bulk Packaging for Hazardous Materials Other Than Class 1 and Class 7 § 173.176 Capacitors. (a) Capacitors, including capacitors containing an electrolyte that does not meet the definition of any...

  1. 49 CFR 173.176 - Capacitors.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 2 2014-10-01 2014-10-01 false Capacitors. 173.176 Section 173.176 Transportation... PACKAGINGS Non-bulk Packaging for Hazardous Materials Other Than Class 1 and Class 7 § 173.176 Capacitors. (a) Capacitors, including capacitors containing an electrolyte that does not meet the definition of any...

  2. 49 CFR 176.134 - Vehicles.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Vehicles. 176.134 Section 176.134 Transportation... Class 1 (Explosive) Materials Stowage § 176.134 Vehicles. Closed vehicles may be used to transport Class... requirements relating to the transport of Class 1 (explosive) materials in vehicles....

  3. 49 CFR 176.134 - Vehicles.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 2 2012-10-01 2012-10-01 false Vehicles. 176.134 Section 176.134 Transportation... Class 1 (Explosive) Materials Stowage § 176.134 Vehicles. Closed vehicles may be used to transport Class... requirements relating to the transport of Class 1 (explosive) materials in vehicles....

  4. 49 CFR 176.134 - Vehicles.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 2 2011-10-01 2011-10-01 false Vehicles. 176.134 Section 176.134 Transportation... Class 1 (Explosive) Materials Stowage § 176.134 Vehicles. Closed vehicles may be used to transport Class... requirements relating to the transport of Class 1 (explosive) materials in vehicles....

  5. Radiolabeling of substance P with lutetium-177 and biodistribution study in rat pancreatic tumor xenografted nude mice.

    PubMed

    De Araújo, E B; Pujatti, P B; Mengatti, J

    2010-05-10

    Pancreatic tumor (PT) is a neuroendocrine neoplasm that usually origin metastases in the respiratory and gastrointestinal tract. The presence of peptide receptors at the cell membrane of PT constitutes the basis of the clinical use of specific radiolabeled ligands for its diagnosis and targeted therapy. Substance P (SP), an 11-amino acid peptide which has an important role in modulating pain transmission trough neurokinin type 1 (NK1r) and 2 receptors (NK2r), may play a role in the pathogenesis of PT, because approximately 10% of these tumors overexpress NK1r. The aim of the present work was to produce a pure and stable SP analog (DOTA-SP) radiolabeled with lutetium-177 ((177)Lu), and to evaluate its in vivo target to AR42J pancreatic tumor cells in Nude mice, in other to verify if SP can be used in this pancreatic tumor detection and treatment. Substance P was successfully labeled with high yield (>99%) at optimized conditions and kept stable for more than 72 hours at 2-8 degrees C and 4 hours in human plasma. Biodistribution studies showed that SP excretion was mainly performed by renal pathway. In addition, (177)Lu-DOTA-SP showed higher uptake by tumor than normal pancreas, indicating the presence of NK receptors in AR42J pancreatic tumor.

  6. Lutetium (177) PSMA radionuclide therapy for men with prostate cancer: a review of the current literature and discussion of practical aspects of therapy.

    PubMed

    Emmett, Louise; Willowson, Kathy; Violet, John; Shin, Jane; Blanksby, Ashley; Lee, Jonathan

    2017-03-01

    Prostate-specific membrane antigen (PSMA) is a receptor on the surface of prostate cancer cells that is revolutionising the way we image and treat men with prostate cancer. New small molecule peptides with high-binding affinity for the PSMA receptor have allowed high quality, highly specific PET imaging, in addition to the development of targeted radionuclide therapy for men with prostate cancer. This targeted therapy for prostate cancer has, to date, predominately used Lutetium 177 (Lu) labelled PSMA peptides. Early clinical studies evaluating the safety and efficacy of Lu PSMA therapy have demonstrated promising results with a significant proportion of men with metastatic prostate cancer, who have already failed other therapies, responding clinically to Lu PSMA. This review discusses the practical issues of administering Lu PSMA, and gives an overview of the findings from currently published trials in regards to treatment response rates, expected toxicities and safety.

  7. Novel functionalized mesopore of SBA-15 as prospective sorbent for praseodymium and lutetium.

    PubMed

    Mallah, M H; Ghannadi Maragheh, M; Badiei, A; Habibzadeh Sbo, R

    In the present work, results of γ-irradiation on normal and functionalized SBA-15 by aurintricarboxylic acid have been reported. Characterization of normal and functionalized SBA-15 particles before and after γ-irradiation was carried out using Fourier-transform infrared technique. Aurintricarboxylic acid ligand connected to SBA-15 was also analyzed using UV/Vis spectrophotometer. The modified sorbent was then used as a new sorbent for separation of trace amounts of praseodymium and lutetium ions from nuclear waste waters in batch techniques. Based on the results of distribution coefficients determination, and investigation of sorption process in various conditions, the parameters were optimized for separation lanthanides. It can be concluded that the functionalized SBA-15 is a promising sorbent for praseodymium and lutetium cations.

  8. de Haas--van Alphen effect and Fermi surface of lutetium

    SciTech Connect

    Johanson, W.R.; Crabtree, G.W.; Schmidt, F.A.

    1984-03-01

    We report de Haas--van Alphen measurements of the Fermi surface of lutetium at temperatures down to 0.3 K and in fields up to 150 kG in the (1010) and (1120) planes. Lutetium, having a filled 4f shell, serves as a nonmagnetic prototype of the structurally similar (hcp), trivalent, heavy rare-earth elements from Gd to Tm. The fact that no complete frequency branches were observed indicates that there are no closed pieces of the Fermi surface. We observed all but one orbit predicted by relativistic augmented-plane-wave calculations of Keeton and Loucks and by recent spin-orbit--linearized-augmented-plane-wave calculations of Tibbetts and Harmon. The data support a geometry similar to that of yttrium, and in good qualitative agreement with energy-band theory.

  9. de Haas-van Alphen effect and Fermi surface of lutetium

    NASA Astrophysics Data System (ADS)

    Johanson, W. R.; Crabtree, G. W.; Schmidt, F. A.

    1984-03-01

    We report de Haas-van Alphen measurements of the Fermi surface of lutetium at temperatures down to 0.3 K and in fields up to 150 kG in the (101¯0) and (112¯0) planes. Lutetium, having a filled 4f shell, serves as a nonmagnetic prototype of the structurally similar (hcp), trivalent, heavy rare-earth elements from Gd to Tm. The fact that no complete frequency branches were observed indicates that there are no closed pieces of the Fermi surface. We observed all but one orbit predicted by relativistic augmented-plane-wave calculations of Keeton and Loucks and by recent spin-orbit-linearized-augmented-plane-wave calculations of Tibbetts and Harmon. The data support a geometry similar to that of yttrium, and in good qualitative agreement with energy-band theory.

  10. Properties of Ce-activated alkali-lutetium double phosphate scintillators

    SciTech Connect

    Wiśniewski, D.; Wojtowicz, A. J.; Boatner, Lynn A

    2010-01-01

    The scintillation properties of Ce-activated alkali-lutetium double phosphate single crystals that vary with the alkali ion type and activation level are summarized and compared. The materials investigated here have been identified as fast and efficient scintillators for the detection of x-ray and radiation, and in case of Li3Lu(PO4)2:Ce, for thermal neutron detection as well.

  11. Heat capacity and thermal expansion of icosahedral lutetium boride LuB66

    SciTech Connect

    Novikov, V V; Avdashchenko, D V; Matovnikov, A V; Mitroshenkov, N V; Bud’ko, S L

    2014-01-07

    The experimental values of heat capacity and thermal expansion for lutetium boride LuB66 in the temperature range of 2-300 K were analysed in the Debye-Einstein approximation. It was found that the vibration of the boron sub-lattice can be considered within the Debye model with high characteristic temperatures; low-frequency vibration of weakly connected metal atoms is described by the Einstein model.

  12. Lutetium(iii) aqua ion: On the dynamical structure of the heaviest lanthanoid hydration complex.

    PubMed

    Sessa, Francesco; Spezia, Riccardo; D'Angelo, Paola

    2016-05-28

    The structure and dynamics of the lutetium(iii) ion in aqueous solution have been investigated by means of a polarizable force field molecular dynamics (MD). An 8-fold square antiprism (SAP) geometry has been found to be the dominant configuration of the lutetium(iii) aqua ion. Nevertheless, a low percentage of 9-fold complexes arranged in a tricapped trigonal prism (TTP) geometry has been also detected. Dynamic properties have been explored by carrying out six independent MD simulations for each of four different temperatures: 277 K, 298 K, 423 K, 632 K. The mean residence time of water molecules in the first hydration shell at room temperature has been found to increase as compared to the central elements of the lanthanoid series in agreement with previous experimental findings. Water exchange kinetic rate constants at each temperature and activation parameters of the process have been determined from the MD simulations. The obtained structural and dynamical results suggest that the water exchange process for the lutetium(iii) aqua ion proceeds with an associative mechanism, in which the SAP hydration complex undergoes temporary structural changes passing through a 9-fold TTP intermediate. Such results are consistent with the water exchange mechanism proposed for heavy lanthanoid atoms.

  13. Biomimetic biosensor based on lipidic layers containing tyrosinase and lutetium bisphthalocyanine for the detection of antioxidants.

    PubMed

    Apetrei, C; Alessio, P; Constantino, C J L; de Saja, J A; Rodriguez-Mendez, M L; Pavinatto, F J; Ramos Fernandes, E Giuliani; Zucolotto, V; Oliveira, O N

    2011-01-15

    This paper describes the preparation of a biomimetic Langmuir-Blodgett film of tyrosinase incorporated in a lipidic layer and the use of lutetium bisphthalocyanine as an electron mediator for the voltammetric detection of phenol derivatives, which include one monophenol (vanillic acid), two diphenols (catechol and caffeic acid) and two triphenols (gallic acid and pyrogallol). The first redox process of the voltammetric responses is associated with the reduction of the enzymatically formed o-quinone and is favoured by the lutetium bisphthalocyanine because significant signal amplification is observed, while the second is associated with the electrochemical oxidation of the antioxidant and occurs at lower potentials in the presence of an electron mediator. The biosensor shows low detection limit (1.98×10(-6)-27.49×10(-6) M), good reproducibility, and high affinity to antioxidants (K(M) in the range of 62.31-144.87 μM). The excellent functionality of the enzyme obtained using a biomimetic immobilisation method, the selectivity afforded by enzyme catalysis, the signal enhancement caused by the lutetium bisphthalocyanine mediator and the increased selectivity of the curves due to the occurrence of two redox processes make these sensors exceptionally suitable for the detection of phenolic compounds.

  14. Lutetium(iii) aqua ion: On the dynamical structure of the heaviest lanthanoid hydration complex

    NASA Astrophysics Data System (ADS)

    Sessa, Francesco; Spezia, Riccardo; D'Angelo, Paola

    2016-05-01

    The structure and dynamics of the lutetium(iii) ion in aqueous solution have been investigated by means of a polarizable force field molecular dynamics (MD). An 8-fold square antiprism (SAP) geometry has been found to be the dominant configuration of the lutetium(iii) aqua ion. Nevertheless, a low percentage of 9-fold complexes arranged in a tricapped trigonal prism (TTP) geometry has been also detected. Dynamic properties have been explored by carrying out six independent MD simulations for each of four different temperatures: 277 K, 298 K, 423 K, 632 K. The mean residence time of water molecules in the first hydration shell at room temperature has been found to increase as compared to the central elements of the lanthanoid series in agreement with previous experimental findings. Water exchange kinetic rate constants at each temperature and activation parameters of the process have been determined from the MD simulations. The obtained structural and dynamical results suggest that the water exchange process for the lutetium(iii) aqua ion proceeds with an associative mechanism, in which the SAP hydration complex undergoes temporary structural changes passing through a 9-fold TTP intermediate. Such results are consistent with the water exchange mechanism proposed for heavy lanthanoid atoms.

  15. Optimizing lutetium 177-anti-carbonic anhydrase IX radioimmunotherapy in an intraperitoneal clear cell renal cell carcinoma xenograft model.

    PubMed

    Muselaers, Constantijn H J; Oosterwijk, Egbert; Bos, Desirée L; Oyen, Wim J G; Mulders, Peter F A; Boerman, Otto C

    2014-01-01

    A new approach in the treatment of clear cell renal carcinoma (ccRCC) is radioimmunotherapy (RIT) using anti-carbonic anhydrase IX (CAIX) antibody G250. To investigate the potential of RIT with lutetium 177 (177Lu)-labeled G250, we conducted a protein dose escalation study and subsequently an RIT study in mice with intraperitoneally growing ccRCC lesions. Mice with intraperitoneal xenografts were injected with 1, 3, 10, 30, or 100 μg of G250 labeled with 10 MBq indium 111 (111In) to determine the optimal protein dose. The optimal protein dose determined with imaging and biodistribution studies was used in a subsequent RIT experiment in three groups of 10 mice with intraperitoneal SK-RC-52 tumors. One group received 13 MBq 177Lu-DOTA-G250, a control group received 13 MBq nonspecific 177Lu-MOPC21, and the second control group was not treated and received 20 MBq 111In-DOTA-G250. The optimal G250 protein dose to target ccRCC in this model was 10 μg G250. Treatment with 13 MBq 177Lu-DOTA-G250 was well tolerated and resulted in significantly prolonged median survival (139 days) compared to controls (49-53 days, p  =  .015), indicating that RIT has potential in this metastatic ccRCC model.

  16. 40 CFR 763.176 - Inspections.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Prohibition of the Manufacture, Importation, Processing, and Distribution in Commerce of Certain Asbestos-Containing Products; Labeling Requirements § 763.176 Inspections. The Agency will conduct inspections...

  17. 2 CFR 176.60 - Statutory requirement.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Statutory requirement. 176.60 Section 176.60 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS NATIONAL POLICY REQUIREMENTS...

  18. 2 CFR 176.70 - Policy.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Policy. 176.70 Section 176.70 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET... public building or public work is located in the United States; and (2) All of the iron, steel,...

  19. 2 CFR 176.70 - Policy.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Policy. 176.70 Section 176.70 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET... public building or public work is located in the United States; and (2) All of the iron, steel,...

  20. 2 CFR 176.40 - Procedure.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Procedure. 176.40 Section 176.40 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS NATIONAL POLICY REQUIREMENTS AWARD TERMS FOR...

  1. 2 CFR 176.30 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Definitions. 176.30 Section 176.30 Grants... (2) Must be protected against unauthorized disclosure according to Executive Order 12958, Classified... and that the recipient awards to an eligible subrecipient; (2) The term does not include the...

  2. 2 CFR 176.60 - Statutory requirement.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Statutory requirement. 176.60 Section 176.60 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS Reserved AWARD TERMS FOR...

  3. 2 CFR 176.40 - Procedure.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Procedure. 176.40 Section 176.40 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS Reserved AWARD TERMS FOR ASSISTANCE AGREEMENTS THAT...

  4. 2 CFR 176.30 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Definitions. 176.30 Section 176.30 Grants... Energy as privately generated restricted data following the procedures in 10 CFR 1045.21; and (2) Must be... recipient awards to an eligible subrecipient; (2) The term does not include the recipient's procurement...

  5. 2 CFR 176.80 - Exceptions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Exceptions. 176.80 Section 176.80 Grants and... manufactured goods needed in the project. (2) Unreasonable cost. The head of the Federal department or agency... manufactured goods may be used— (1) The award official shall list the excepted materials in the award; and...

  6. 2 CFR 176.30 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Definitions. 176.30 Section 176.30 Grants... (2) Must be protected against unauthorized disclosure according to Executive Order 12958, Classified... and that the recipient awards to an eligible subrecipient; (2) The term does not include the...

  7. 2 CFR 176.80 - Exceptions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Exceptions. 176.80 Section 176.80 Grants and... project. (2) Unreasonable cost. The head of the Federal department or agency may determine that the cost... manufactured goods may be used— (1) The award official shall list the excepted materials in the award; and...

  8. 2 CFR 176.60 - Statutory requirement.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Statutory requirement. 176.60 Section 176.60 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS NATIONAL POLICY REQUIREMENTS...

  9. 2 CFR 176.180 - Procedure.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Procedure. 176.180 Section 176.180 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS NATIONAL POLICY REQUIREMENTS AWARD...

  10. 2 CFR 176.80 - Exceptions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Exceptions. 176.80 Section 176.80 Grants and... manufactured goods needed in the project. (2) Unreasonable cost. The head of the Federal department or agency... manufactured goods may be used— (1) The award official shall list the excepted materials in the award; and...

  11. 2 CFR 176.70 - Policy.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Policy. 176.70 Section 176.70 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET... public building or public work is located in the United States; and (2) All of the iron, steel,...

  12. 2 CFR 176.40 - Procedure.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Procedure. 176.40 Section 176.40 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS NATIONAL POLICY REQUIREMENTS AWARD TERMS FOR...

  13. 40 CFR 763.176 - Inspections.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Inspections. 763.176 Section 763.176 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT ASBESTOS Prohibition of the Manufacture, Importation, Processing, and Distribution in Commerce of Certain...

  14. 46 CFR 176.802 - Hull.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Hull. 176.802 Section 176.802 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) INSPECTION AND..., running rigging, blocks, fittings, and sails; (4) Inspection of all railings and bulwarks and...

  15. 34 CFR 303.176 - Data collection.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false Data collection. 303.176 Section 303.176 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND... Data collection. Each application must include procedures that meet the requirements in §...

  16. 34 CFR 303.176 - Data collection.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 2 2011-07-01 2010-07-01 true Data collection. 303.176 Section 303.176 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND... Data collection. Each application must include procedures that meet the requirements in §...

  17. 2 CFR 176.40 - Procedure.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Procedure. 176.40 Section 176.40 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS AWARD TERMS FOR ASSISTANCE AGREEMENTS THAT INCLUDE FUNDS...

  18. 2 CFR 176.200 - Procedure.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Procedure. 176.200 Section 176.200 Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS Reserved AWARD TERMS FOR ASSISTANCE AGREEMENTS THAT INCLUDE FUNDS UNDER THE AMERICAN RECOVERY...

  19. 2 CFR 176.30 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Definitions. 176.30 Section 176.30 Grants... generated restricted data following the procedures in 10 CFR 1045.21; and (2) Must be protected against... eligible subrecipient; (2) The term does not include the recipient's procurement of property and...

  20. 2 CFR 176.80 - Exceptions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Exceptions. 176.80 Section 176.80 Grants and... manufactured goods needed in the project. (2) Unreasonable cost. The head of the Federal department or agency... manufactured goods may be used— (1) The award official shall list the excepted materials in the award; and...

  1. 2 CFR 176.30 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Definitions. 176.30 Section 176.30 Grants... procedures in 10 CFR 1045.21; and (2) Must be protected against unauthorized disclosure according to... recipient received this award and that the recipient awards to an eligible subrecipient; (2) The term...

  2. 2 CFR 176.70 - Policy.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Policy. 176.70 Section 176.70 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET... public work is located in the United States; and (2) All of the iron, steel, and manufactured goods...

  3. 2 CFR 176.180 - Procedure.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Procedure. 176.180 Section 176.180 Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS Reserved AWARD TERMS FOR ASSISTANCE AGREEMENTS THAT INCLUDE FUNDS UNDER THE AMERICAN RECOVERY...

  4. 2 CFR 176.60 - Statutory requirement.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Statutory requirement. 176.60 Section 176.60 Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS Reserved AWARD TERMS FOR ASSISTANCE AGREEMENTS THAT INCLUDE FUNDS UNDER THE AMERICAN RECOVERY...

  5. 2 CFR 176.80 - Exceptions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Exceptions. 176.80 Section 176.80 Grants and... project. (2) Unreasonable cost. The head of the Federal department or agency may determine that the cost... manufactured goods may be used— (1) The award official shall list the excepted materials in the award; and...

  6. 2 CFR 176.60 - Statutory requirement.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Statutory requirement. 176.60 Section 176.60 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS AWARD TERMS FOR ASSISTANCE...

  7. 2 CFR 176.40 - Procedure.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Procedure. 176.40 Section 176.40 Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS Reserved AWARD TERMS FOR ASSISTANCE AGREEMENTS THAT INCLUDE FUNDS UNDER THE AMERICAN RECOVERY AND REINVESTMENT ACT...

  8. 2 CFR 176.70 - Policy.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Policy. 176.70 Section 176.70 Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS Reserved AWARD....160) unless— (1) The public building or public work is located in the United States; and (2) All...

  9. 21 CFR 211.176 - Penicillin contamination.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 4 2012-04-01 2012-04-01 false Penicillin contamination. 211.176 Section 211.176... Penicillin contamination. If a reasonable possibility exists that a non-penicillin drug product has been exposed to cross-contamination with penicillin, the non-penicillin drug product shall be tested for...

  10. 21 CFR 211.176 - Penicillin contamination.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Penicillin contamination. 211.176 Section 211.176... Penicillin contamination. If a reasonable possibility exists that a non-penicillin drug product has been exposed to cross-contamination with penicillin, the non-penicillin drug product shall be tested for...

  11. 21 CFR 211.176 - Penicillin contamination.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 4 2014-04-01 2014-04-01 false Penicillin contamination. 211.176 Section 211.176... Penicillin contamination. If a reasonable possibility exists that a non-penicillin drug product has been exposed to cross-contamination with penicillin, the non-penicillin drug product shall be tested for...

  12. 21 CFR 211.176 - Penicillin contamination.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 4 2011-04-01 2011-04-01 false Penicillin contamination. 211.176 Section 211.176... Penicillin contamination. If a reasonable possibility exists that a non-penicillin drug product has been exposed to cross-contamination with penicillin, the non-penicillin drug product shall be tested for...

  13. 21 CFR 211.176 - Penicillin contamination.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 4 2013-04-01 2013-04-01 false Penicillin contamination. 211.176 Section 211.176... Penicillin contamination. If a reasonable possibility exists that a non-penicillin drug product has been exposed to cross-contamination with penicillin, the non-penicillin drug product shall be tested for...

  14. 7 CFR 989.176 - Records.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 8 2014-01-01 2014-01-01 false Records. 989.176 Section 989.176 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... maintain complete, accurate, and current records of all of his business affairs concerning which he...

  15. 7 CFR 989.176 - Records.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Records. 989.176 Section 989.176 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... maintain complete, accurate, and current records of all of his business affairs concerning which he...

  16. 7 CFR 989.176 - Records.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 8 2011-01-01 2011-01-01 false Records. 989.176 Section 989.176 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... maintain complete, accurate, and current records of all of his business affairs concerning which he...

  17. 49 CFR 176.148 - Artificial lighting.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 2 2013-10-01 2013-10-01 false Artificial lighting. 176.148 Section 176.148 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY... lighting. Electric lights, except arc lights, are the only form of artificial lighting permitted...

  18. 49 CFR 176.148 - Artificial lighting.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 2 2014-10-01 2014-10-01 false Artificial lighting. 176.148 Section 176.148 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY... lighting. Electric lights, except arc lights, are the only form of artificial lighting permitted...

  19. 49 CFR 176.148 - Artificial lighting.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 2 2011-10-01 2011-10-01 false Artificial lighting. 176.148 Section 176.148 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY... lighting. Electric lights, except arc lights, are the only form of artificial lighting permitted...

  20. 49 CFR 176.148 - Artificial lighting.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Artificial lighting. 176.148 Section 176.148 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY... lighting. Electric lights, except arc lights, are the only form of artificial lighting permitted...

  1. 49 CFR 176.148 - Artificial lighting.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 2 2012-10-01 2012-10-01 false Artificial lighting. 176.148 Section 176.148 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY... lighting. Electric lights, except arc lights, are the only form of artificial lighting permitted...

  2. 49 CFR 176.132 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false 176.132 Section 176.132 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS REGULATIONS CARRIAGE BY VESSEL Detailed Requirements for Class 1 (Explosive) Materials Stowage §...

  3. 49 CFR 176.118 - Electrical requirement.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... in the compartments must be enclosed in metal-clad junction boxes. (e) All lighting equipment and... of 46 CFR chapter I, subchapter J. [Amdt. 176-30, 55 FR 52696, Dec. 21, 1990, as amended by Amdt. 176-34, 58 FR 51533, Oct. 1, 1993]...

  4. 46 CFR 160.176-8 - Materials.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... to this test. Materials that are covered when used in the lifejacket may be tested with the covering... 46 Shipping 6 2011-10-01 2011-10-01 false Materials. 160.176-8 Section 160.176-8 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) EQUIPMENT, CONSTRUCTION, AND...

  5. 46 CFR 160.176-8 - Materials.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... to this test. Materials that are covered when used in the lifejacket may be tested with the covering... 46 Shipping 6 2012-10-01 2012-10-01 false Materials. 160.176-8 Section 160.176-8 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) EQUIPMENT, CONSTRUCTION, AND...

  6. Phase I trial of motexafin-lutetium-mediated interstitial photodynamic therapy in patients with locally recurrent prostate cancer

    NASA Astrophysics Data System (ADS)

    Stripp, Diana C. H.; Mick, Rosemarie; Zhu, Timothy C.; Whittington, Richard; Smith, Debbie; Dimofte, Andreea; Finlay, Jarod C.; Miles, Jeremy; Busch, Theresa M.; Shin, Daniel; Kachur, Alex; Tochner, Zelig A.; Malkowicz, S. Bruce; Glatstein, Eli; Hahn, Stephen M.

    2004-06-01

    Therapeutic options for patients with locally recurrent prostate cancer after treatment with radiation therapy are limited. An ongoing Phase I trial of interstitial photodynamic therapy (PDT) with the photosensitizer motexafin lutetium (MLu) was initiated in year 2000 for men with locally recurrent prostate cancer. The primary objective of this trial is to determine the maximally tolerated dose of motexafin lutetium-mediated PDT. Twelve men with biopsy-proven recurrent prostate cancer and no evidence of distant metastatic disease have been enrolled. Pre-treatment evaluation included an MRI of the prostate, bone scan, laboratory studies, cystoscopy, and transrectal ultrasound. Treatment plans were generated based upon the ultrasound findings. PDT dose was escalated by increasing the motexafin lutetium dose, increasing the 732 nm light dose, and decreasing the drug-light interval. Motexafin lutetium doses ranged from 0.5 to 2 mg/kg administered IV 3, 6, or 24 hours prior to 732 nm light delivery. The light dose measured in real time with in situ spherical detectors was 25-100 J/cm2 for all patients. Light was delivered through optical fibers inserted through a transperineal brachytherapy template in the operating room and optical property measurements were made before and after light therapy. Prostate biopsies were obtained before and after light delivery for spectrofluorometric measurements of photosensitizer uptake. Twelve patients have completed protocol treatment on eight dose levels without dose-limiting toxicity. Grade I PDT-related genitourinary symptoms were observed. One patient had Grade II urinary urgency that was urinary catheter-related. No rectal or other GI PDT-related toxicities were observed. Measurements of motexafin lutetium in prostate tissue demonstrated the presence of photosensitizer at all dose levels. Conclusions: Motexafin lutetium-mediated PDT designed to treat comprehensively the entired prostate gland has been well-tolerated at the doses

  7. Syntheses and structures of mononuclear lutetium imido complexes with very short Lu-N bonds.

    PubMed

    Panda, Tarun K; Randoll, Sören; Hrib, Cristian G; Jones, Peter G; Bannenberg, Thomas; Tamm, Matthias

    2007-12-21

    The reaction of 1,3-bis(2,6-diisopropylphenyl)imidazolin-2-imine (ImDippNH) with trimethylsilylmethyllithium and anhydrous lutetium trichloride affords the imido complex [LuCl2(ImNDipp)(THF)3], which, on further reaction with dipotassium cyclooctatetraenide, K2(C8H8), leads to the half-sandwich cyclooctatetraenyl complex [(eta8-C8H8)Lu(ImNDipp)(THF)2]; both complexes contain very short Lu-N bond lengths, which are shorter than any previously reported Lu-N distances.

  8. Growth of epitaxial bismuth and gallium substituted lutetium iron garnet films by pulsed laser deposition

    SciTech Connect

    Leitenmeier, Stephan; Heinrich, Andreas; Lindner, Joerg K. N.; Stritzker, Bernd

    2006-04-15

    Epitaxial bismuth and gallium substituted lutetium iron garnet thin films have been grown on (100) oriented gadolinium gallium garnet Gd{sub 3}Ga{sub 5}O{sub 12} substrates by pulsed laser deposition. The films have been studied using x-ray diffraction, high resolution x-ray diffraction, Rutherford backscattering spectroscopy, transmission electron microscopy, and electron diffraction. We obtained smooth films with thicknesses between 0.3 and 1.0 {mu}m showing good crystalline quality and epitaxial growth.

  9. Lutetium alkyl and hydride complexes in a non-cyclopentadienyl coordination environment.

    PubMed

    Konkol, Marcin; Spaniol, Thomas P; Kondracka, Małgorzata; Okuda, Jun

    2007-09-28

    Lutetium alkyl complexes [Lu(L)(CH(2)SiMe(3))(THF)(n)], which contain a sulfur-linked bis(phenolato) ligand such as 2,2'-thiobis(6-tert-butyl-4-methylphenolate) (L=tbmp, 1) or 1,4-dithiabutanediyl-bis(6-tert-butyl-4-methylphenolate) (L=etbmp, 2), were isolated from the reaction of the lutetium tris(alkyl) complex [Lu(CH(2)SiMe(3))(3)(THF)(2)] with H(2)L. The monomeric structures of these complexes were confirmed by X-ray diffraction studies, showing distorted octahedral geometry around the metal centre. The reaction of [Lu(tbmp)(CH(2)SiMe(3))(THF)(2)] (1) with alcohols ROH (R=iPr, CHPh(2), CPh(3)) results in the formation of the corresponding alkoxide complexes [Lu(tbmp)(OR)(THF)(n)] (4-6). With PhSiH(3) hydride complexes [Lu(L)(mu-H)(THF)(n)](2) (L=tbmp, 7; etbmp, 8) have been prepared in moderate to good yields. They adopt a dimeric form in the solid state as revealed by the X-ray crystal structure of 7. The reactivity of the hydride complexes and their catalytic activity in the ring-opening polymerisation of L-lactide and the hydrosilylation of alkenes are also discussed.

  10. Atomic and electronic structures of lutetium oxide Lu{sub 2}O{sub 3}

    SciTech Connect

    Kaichev, V. V.; Asanova, T. I.; Erenburg, S. B.; Perevalov, T. V.; Shvets, V. A.; Gritsenko, V. A.

    2013-02-15

    The chemical composition, electronic structure, structure, and physical properties a lutetium oxide Lu{sub 2}O{sub 3} film are studied by X-ray photoelectron spectroscopy, ellipsometry, and X-ray absorption spectroscopy. The short-range order in Lu{sub 2}O{sub 3} is found to correspond to its cubic modification. The binding energies of the 1s and 2p levels of oxygen and the 4d{sub 5/2} and 4f{sub 7/2} levels of lutetium are 529.2, 5.0 and 7.4, 195.9 eV, respectively. The energy gap determined from the electron energy loss spectrum of the film is 5.9 eV. The electron energy loss spectra have two peaks at 17.4 and 22.0 eV, which can be attributed to the excitation of bulk plasma oscillations. The dispersion of the refractive index is measured by spectral ellipsometry. The refractive index is shown to increase from 1.82 at 1.5 eV to 2.18 at 5.0 eV, and the high-frequency permittivity of Lu{sub 2}O{sub 3} is 3.31.

  11. On the photoelectron velocity-map imaging of lutetium monoxide anion LuO{sup −}

    SciTech Connect

    Liu, Zhiling; Xie, Hua; Qin, Zhengbo; Cong, Ran; Wu, Xia; Tang, Zichao Fan, Hongjun; Li, Quanjiang

    2014-01-21

    We report a combined photoelectron velocity-map imaging spectroscopy and density functional theory investigation on lutetium monoxide anion. Transition between the X {sup 1}Σ{sup +} anion electronic ground state and the neutral X {sup 2}Σ{sup +} electronic ground state is observed. Vibrationally resolved spectra were obtained at four different photon energies, providing a wealth of spectroscopic information for the electronic ground states of the anionic lutetium monoxide and corresponding neutral species. Franck-Condon simulations of the ground-state transition are performed to assign vibrational structure in the spectra and to assist in identifying the observed spectral bands. The electronic ground state of LuO{sup −} is found to have a vibrational frequency of 743 ± 10 cm{sup −1} and an equilibrium bond length of 1.841 Å. The electron affinity of LuO is measured to be 1.624 ± 0.002 eV. The fundamental frequency of ground-state LuO is estimated to be 839 ± 10 cm{sup −1}.

  12. On the photoelectron velocity-map imaging of lutetium monoxide anion LuO(-).

    PubMed

    Liu, Zhiling; Xie, Hua; Li, Quanjiang; Qin, Zhengbo; Cong, Ran; Wu, Xia; Tang, Zichao; Fan, Hongjun

    2014-01-21

    We report a combined photoelectron velocity-map imaging spectroscopy and density functional theory investigation on lutetium monoxide anion. Transition between the X (1)Σ(+) anion electronic ground state and the neutral X (2)Σ(+) electronic ground state is observed. Vibrationally resolved spectra were obtained at four different photon energies, providing a wealth of spectroscopic information for the electronic ground states of the anionic lutetium monoxide and corresponding neutral species. Franck-Condon simulations of the ground-state transition are performed to assign vibrational structure in the spectra and to assist in identifying the observed spectral bands. The electronic ground state of LuO(-) is found to have a vibrational frequency of 743 ± 10 cm(-1) and an equilibrium bond length of 1.841 Å. The electron affinity of LuO is measured to be 1.624 ± 0.002 eV. The fundamental frequency of ground-state LuO is estimated to be 839 ± 10 cm(-1).

  13. 49 CFR 176.138 - Deck stowage.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS REGULATIONS CARRIAGE BY VESSEL Detailed Requirements for Class 1 (Explosive) Materials Stowage § 176.138 Deck stowage. (a) [Reserved] (b) Class...

  14. 49 CFR 176.178 - Mooring lines.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS REGULATIONS CARRIAGE BY VESSEL Detailed Requirements for Class 1 (Explosive) Materials Handling Class 1 (explosive) Materials in Port § 176.178...

  15. 49 CFR 176.178 - Mooring lines.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS REGULATIONS CARRIAGE BY VESSEL Detailed Requirements for Class 1 (Explosive) Materials Handling Class 1 (explosive) Materials in Port § 176.178...

  16. 49 CFR 176.178 - Mooring lines.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS REGULATIONS CARRIAGE BY VESSEL Detailed Requirements for Class 1 (Explosive) Materials Handling Class 1 (explosive) Materials in Port § 176.178...

  17. 49 CFR 176.178 - Mooring lines.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS REGULATIONS CARRIAGE BY VESSEL Detailed Requirements for Class 1 (Explosive) Materials Handling Class 1 (explosive) Materials in Port § 176.178...

  18. 2 CFR 176.180 - Procedure.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS NATIONAL POLICY REQUIREMENTS AWARD TERMS... of 2009 § 176.180 Procedure. The award official shall insert the standard award term in this...

  19. 49 CFR 176.120 - Lightning protection.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS REGULATIONS CARRIAGE BY VESSEL Detailed Requirements for Class 1 (Explosive) Materials Stowage § 176.120 Lightning protection. A lightning...

  20. Inclusion complexes of trivalent lutetium cations with an acidic derivative of per(3,6-anhydro)-alpha-cyclodextrin.

    PubMed

    Bonnet, Célia; Gadelle, Andrée; Pécaut, Jacques; Fries, Pascal H; Delangle, Pascale

    2005-02-07

    The cyclodextrin derivative (hexakis (2-O-carboxymethyl-3,6-anhydro)-alpha-cyclodextrin) forms mono- and bimetallic complexes with lutetium(III) in aqueous solution; the X-ray structure of the binuclear complex [Lu2(ACX)(H2O)2] is the first example of a lanthanide-cyclodextrin inclusion complex.

  1. 49 CFR 176.133 - Magazine stowage Type C.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Magazine stowage Type C. 176.133 Section 176.133... Requirements for Class 1 (Explosive) Materials Stowage § 176.133 Magazine stowage Type C. The construction requirements for magazine stowage type C are the same as for a closed cargo transport unit in § 176.63(e)....

  2. Vacuum ultraviolet field emission lamp consisting of neodymium ion doped lutetium fluoride thin film as phosphor.

    PubMed

    Yanagihara, Masahiro; Tsuji, Takayuki; Yusop, Mohd Zamri; Tanemura, Masaki; Ono, Shingo; Nagami, Tomohito; Fukuda, Kentaro; Suyama, Toshihisa; Yokota, Yuui; Yanagida, Takayuki; Yoshikawa, Akira

    2014-01-01

    A vacuum ultraviolet (VUV) field emission lamp was developed by using a neodymium ion doped lutetium fluoride (Nd(3+) : LuF3) thin film as solid-state phosphor and carbon nanofiber field electron emitters. The thin film was synthesized by pulsed laser deposition and incorporated into the lamp. The cathodoluminescence spectra of the lamp showed multiple emission peaks at 180, 225, and 255 nm. These emission spectra were in good agreement with the spectra reported for the Nd(3+) : LuF3 crystal. Moreover, application of an acceleration voltage effectively increased the emission intensity. These results contribute to the performance enhancement of the lamp operating in the VUV region.

  3. Vacuum Ultraviolet Field Emission Lamp Consisting of Neodymium Ion Doped Lutetium Fluoride Thin Film as Phosphor

    PubMed Central

    Yanagihara, Masahiro; Tsuji, Takayuki; Yusop, Mohd Zamri; Tanemura, Masaki; Nagami, Tomohito; Fukuda, Kentaro; Suyama, Toshihisa; Yokota, Yuui; Yanagida, Takayuki; Yoshikawa, Akira

    2014-01-01

    A vacuum ultraviolet (VUV) field emission lamp was developed by using a neodymium ion doped lutetium fluoride (Nd3+ : LuF3) thin film as solid-state phosphor and carbon nanofiber field electron emitters. The thin film was synthesized by pulsed laser deposition and incorporated into the lamp. The cathodoluminescence spectra of the lamp showed multiple emission peaks at 180, 225, and 255 nm. These emission spectra were in good agreement with the spectra reported for the Nd3+ : LuF3 crystal. Moreover, application of an acceleration voltage effectively increased the emission intensity. These results contribute to the performance enhancement of the lamp operating in the VUV region. PMID:25302320

  4. Photoemission spectroscopy study of the lanthanum lutetium oxide/silicon interface

    SciTech Connect

    Nichau, A.; Schnee, M.; Schubert, J.; Bernardy, P.; Hollaender, B.; Buca, D.; Mantl, S.; Besmehn, A.; Breuer, U.; Rubio-Zuazo, J.; Castro, G. R.; Muecklich, A.; Borany, J. von

    2013-04-21

    Rare earth oxides are promising candidates for future integration into nano-electronics. A key property of these oxides is their ability to form silicates in order to replace the interfacial layer in Si-based complementary metal-oxide field effect transistors. In this work a detailed study of lanthanum lutetium oxide based gate stacks is presented. Special attention is given to the silicate formation at temperatures typical for CMOS processing. The experimental analysis is based on hard x-ray photoemission spectroscopy complemented by standard laboratory experiments as Rutherford backscattering spectrometry and high-resolution transmission electron microscopy. Homogenously distributed La silicate and Lu silicate at the Si interface are proven to form already during gate oxide deposition. During the thermal treatment Si atoms diffuse through the oxide layer towards the TiN metal gate. This mechanism is identified to be promoted via Lu-O bonds, whereby the diffusion of La was found to be less important.

  5. Photoelectric conversion and electrochromic properties of lutetium tetrakis(tert-butyl)bisphthalocyaninate

    SciTech Connect

    Hu, Andrew Teh; Hu Tenyi; Liu Lungchang

    2003-12-10

    Both photoelectric and electrochromic effects on lutetium tetrakis(tert-butyl)bisphthalocyaninate (Lu(TBPc){sub 2}) have been carried out in this study. Lu(TBPc){sub 2} is known for its electrochromic performance, but its photoelectric effect has not mentioned in the literature. The electrochromic properties of Lu(TBPc){sub 2} have been measured by cyclic voltammetry (CV) and UV-Vis spectrometer at the same time. It takes less than 1.5 s for the color to change from red to green under 0.9 V. Its cycle life is at least over 500 times. Furthermore, we also investigate its photoelectric conversion properties. Its photoelectric cell exhibits a positive photo-electricity conversion effect with a short-circuit photocurrent (46.4 {mu}A/cm{sup 2}) under illumination of white light (1.201 mW/cm{sup 2})

  6. 49 CFR 176.27 - Certificate.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... import or export shipment of a hazardous material that will not be transported by rail, highway, or air... Requirements § 176.27 Certificate. (a) A carrier may not transport a hazardous material by vessel unless a... transport vehicle with packages of hazardous materials for transportation by a manned vessel in ocean...

  7. 49 CFR 176.27 - Certificate.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... import or export shipment of a hazardous material that will not be transported by rail, highway, or air... Requirements § 176.27 Certificate. (a) A carrier may not transport a hazardous material by vessel unless a... transport vehicle with packages of hazardous materials for transportation by a manned vessel in ocean...

  8. 40 CFR 61.176 - Recordkeeping requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Arsenic Emissions From Primary Copper Smelters § 61.176 Recordkeeping requirements. (a) Each owner or... each copper converter department, a monthly record of the weight percent of arsenic contained in the..., the monthly calculations of the average annual arsenic charging rate for the preceding 12-month...

  9. 40 CFR 61.176 - Recordkeeping requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Arsenic Emissions From Primary Copper Smelters § 61.176 Recordkeeping requirements. (a) Each owner or... each copper converter department, a monthly record of the weight percent of arsenic contained in the..., the monthly calculations of the average annual arsenic charging rate for the preceding 12-month...

  10. 40 CFR 61.176 - Recordkeeping requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Arsenic Emissions From Primary Copper Smelters § 61.176 Recordkeeping requirements. (a) Each owner or... each copper converter department, a monthly record of the weight percent of arsenic contained in the..., the monthly calculations of the average annual arsenic charging rate for the preceding 12-month...

  11. 40 CFR 61.176 - Recordkeeping requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Arsenic Emissions From Primary Copper Smelters § 61.176 Recordkeeping requirements. (a) Each owner or... each copper converter department, a monthly record of the weight percent of arsenic contained in the..., the monthly calculations of the average annual arsenic charging rate for the preceding 12-month...

  12. 40 CFR 61.176 - Recordkeeping requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Arsenic Emissions From Primary Copper Smelters § 61.176 Recordkeeping requirements. (a) Each owner or... each copper converter department, a monthly record of the weight percent of arsenic contained in the..., the monthly calculations of the average annual arsenic charging rate for the preceding 12-month...

  13. 49 CFR 176.24 - Shipping papers.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS REGULATIONS CARRIAGE BY VESSEL General Operating Requirements § 176.24 Shipping papers. (a) A person may not accept a hazardous material for transportation...

  14. 32 CFR 176.30 - LRA application.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... BASE CLOSURE COMMUNITIES AND COMMUNITY ASSISTANCE-COMMUNITY REDEVELOPMENT AND HOMELESS ASSISTANCE § 176... application. (b) Homeless assistance submission. This component of the application shall include the following... about any gaps that exist in the continuum of care for particular homeless subpopulations. The...

  15. 32 CFR 176.10 - Applicability.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... BASE CLOSURE COMMUNITIES AND COMMUNITY ASSISTANCE-COMMUNITY REDEVELOPMENT AND HOMELESS ASSISTANCE § 176... specifically address any application for use of buildings and property to assist the homeless that were... pending requests shall be addressed in the LRA's homeless assistance submission. (2) For...

  16. 32 CFR 176.1 - Purpose.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... COMMUNITIES AND COMMUNITY ASSISTANCE-COMMUNITY REDEVELOPMENT AND HOMELESS ASSISTANCE § 176.1 Purpose. This part implements the Base Closure Community Redevelopment and Homeless Assistance Act, as amended (10 U... homeless at base closure and realignment sites. In this process, Local Redevelopment Authorities...

  17. 32 CFR 176.5 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... BASE CLOSURE COMMUNITIES AND COMMUNITY ASSISTANCE-COMMUNITY REDEVELOPMENT AND HOMELESS ASSISTANCE § 176... system. (1) A comprehensive homeless assistance system that includes: (i) A system of outreach and assessment for determining the needs and condition of an individual or family who is homeless, or...

  18. 32 CFR 176.30 - LRA application.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... BASE CLOSURE COMMUNITIES AND COMMUNITY ASSISTANCE-COMMUNITY REDEVELOPMENT AND HOMELESS ASSISTANCE § 176... application. (b) Homeless assistance submission. This component of the application shall include the following... about any gaps that exist in the continuum of care for particular homeless subpopulations. The...

  19. 32 CFR 176.30 - LRA application.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... BASE CLOSURE COMMUNITIES AND COMMUNITY ASSISTANCE-COMMUNITY REDEVELOPMENT AND HOMELESS ASSISTANCE § 176... application. (b) Homeless assistance submission. This component of the application shall include the following... about any gaps that exist in the continuum of care for particular homeless subpopulations. The...

  20. 32 CFR 176.10 - Applicability.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... BASE CLOSURE COMMUNITIES AND COMMUNITY ASSISTANCE-COMMUNITY REDEVELOPMENT AND HOMELESS ASSISTANCE § 176... specifically address any application for use of buildings and property to assist the homeless that were... pending requests shall be addressed in the LRA's homeless assistance submission. (2) For...

  1. 32 CFR 176.10 - Applicability.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... BASE CLOSURE COMMUNITIES AND COMMUNITY ASSISTANCE-COMMUNITY REDEVELOPMENT AND HOMELESS ASSISTANCE § 176... specifically address any application for use of buildings and property to assist the homeless that were... pending requests shall be addressed in the LRA's homeless assistance submission. (2) For...

  2. 32 CFR 176.10 - Applicability.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... BASE CLOSURE COMMUNITIES AND COMMUNITY ASSISTANCE-COMMUNITY REDEVELOPMENT AND HOMELESS ASSISTANCE § 176... specifically address any application for use of buildings and property to assist the homeless that were... pending requests shall be addressed in the LRA's homeless assistance submission. (2) For...

  3. 32 CFR 176.1 - Purpose.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... COMMUNITIES AND COMMUNITY ASSISTANCE-COMMUNITY REDEVELOPMENT AND HOMELESS ASSISTANCE § 176.1 Purpose. This part implements the Base Closure Community Redevelopment and Homeless Assistance Act, as amended (10 U... homeless at base closure and realignment sites. In this process, Local Redevelopment Authorities...

  4. 32 CFR 176.1 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... COMMUNITIES AND COMMUNITY ASSISTANCE-COMMUNITY REDEVELOPMENT AND HOMELESS ASSISTANCE § 176.1 Purpose. This part implements the Base Closure Community Redevelopment and Homeless Assistance Act, as amended (10 U... homeless at base closure and realignment sites. In this process, Local Redevelopment Authorities...

  5. 32 CFR 176.1 - Purpose.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... COMMUNITIES AND COMMUNITY ASSISTANCE-COMMUNITY REDEVELOPMENT AND HOMELESS ASSISTANCE § 176.1 Purpose. This part implements the Base Closure Community Redevelopment and Homeless Assistance Act, as amended (10 U... homeless at base closure and realignment sites. In this process, Local Redevelopment Authorities...

  6. 32 CFR 176.5 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... BASE CLOSURE COMMUNITIES AND COMMUNITY ASSISTANCE-COMMUNITY REDEVELOPMENT AND HOMELESS ASSISTANCE § 176... system. (1) A comprehensive homeless assistance system that includes: (i) A system of outreach and assessment for determining the needs and condition of an individual or family who is homeless, or...

  7. 32 CFR 176.10 - Applicability.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... BASE CLOSURE COMMUNITIES AND COMMUNITY ASSISTANCE-COMMUNITY REDEVELOPMENT AND HOMELESS ASSISTANCE § 176... specifically address any application for use of buildings and property to assist the homeless that were... pending requests shall be addressed in the LRA's homeless assistance submission. (2) For...

  8. 32 CFR 176.1 - Purpose.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... COMMUNITIES AND COMMUNITY ASSISTANCE-COMMUNITY REDEVELOPMENT AND HOMELESS ASSISTANCE § 176.1 Purpose. This part implements the Base Closure Community Redevelopment and Homeless Assistance Act, as amended (10 U... homeless at base closure and realignment sites. In this process, Local Redevelopment Authorities...

  9. 46 CFR 176.670 - Tailshaft examinations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...) INSPECTION AND CERTIFICATION Hull and Tailshaft Examinations § 176.670 Tailshaft examinations. (a) The marine inspector may require any part or all of the propeller shafting to be drawn for examination of the shafting...) The marine inspector may conduct a visual examination and may require nondestructive testing of...

  10. 46 CFR 176.670 - Tailshaft examinations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...) INSPECTION AND CERTIFICATION Hull and Tailshaft Examinations § 176.670 Tailshaft examinations. (a) The marine inspector may require any part or all of the propeller shafting to be drawn for examination of the shafting...) The marine inspector may conduct a visual examination and may require nondestructive testing of...

  11. 46 CFR 176.670 - Tailshaft examinations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...) INSPECTION AND CERTIFICATION Hull and Tailshaft Examinations § 176.670 Tailshaft examinations. (a) The marine inspector may require any part or all of the propeller shafting to be drawn for examination of the shafting...) The marine inspector may conduct a visual examination and may require nondestructive testing of...

  12. 46 CFR 176.670 - Tailshaft examinations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...) INSPECTION AND CERTIFICATION Hull and Tailshaft Examinations § 176.670 Tailshaft examinations. (a) The marine inspector may require any part or all of the propeller shafting to be drawn for examination of the shafting...) The marine inspector may conduct a visual examination and may require nondestructive testing of...

  13. 46 CFR 176.670 - Tailshaft examinations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...) INSPECTION AND CERTIFICATION Hull and Tailshaft Examinations § 176.670 Tailshaft examinations. (a) The marine inspector may require any part or all of the propeller shafting to be drawn for examination of the shafting...) The marine inspector may conduct a visual examination and may require nondestructive testing of...

  14. 46 CFR 176.800 - Inspection standards.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) INSPECTION AND CERTIFICATION Material Inspections § 176.800 Inspection standards. (a) A vessel is inspected... acceptable to the cognizant OCMI as good marine practice. (b) In the application of inspection standards...

  15. 46 CFR 176.800 - Inspection standards.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) INSPECTION AND CERTIFICATION Material Inspections § 176.800 Inspection standards. (a) A vessel is inspected... acceptable to the cognizant OCMI as good marine practice. (b) In the application of inspection standards...

  16. 46 CFR 176.800 - Inspection standards.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) INSPECTION AND CERTIFICATION Material Inspections § 176.800 Inspection standards. (a) A vessel is inspected... acceptable to the cognizant OCMI as good marine practice. (b) In the application of inspection standards...

  17. 46 CFR 176.800 - Inspection standards.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) INSPECTION AND CERTIFICATION Material Inspections § 176.800 Inspection standards. (a) A vessel is inspected... acceptable to the cognizant OCMI as good marine practice. (b) In the application of inspection standards...

  18. 46 CFR 176.800 - Inspection standards.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... recognized safety associations may be used as guides in the inspection of vessels when such standards do not... COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) INSPECTION AND CERTIFICATION Material Inspections § 176.800 Inspection standards. (a) A vessel is...

  19. 46 CFR 176.810 - Fire protection.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Type system Test Carbon dioxide Weigh cylinders. Recharge cylinder if weight loss exceeds 10 percent of...) INSPECTION AND CERTIFICATION Material Inspections § 176.810 Fire protection. (a) At each initial and subsequent inspection for certification, the owner or managing operator shall be prepared to conduct...

  20. A new coprecipitation methodology with lutetium hydroxide for preconcentration of heavy metal ions in herbal plant samples.

    PubMed

    Soylak, Mustafa; Murat, Ipek

    2014-01-01

    A new coprecipitation methodology that used lutetium hydroxide as a precipitant for Cu(II), Pb(II), Mn(II), Co(II), Cd(II), Fe(III), and Ni(II) ions in herbal plant and water samples for analysis by atomic absorption spectrometry has been investigated. The parameters such as pH, amount of lutetium, and volume of aqueous sample were optimized for the recovery of these seven metals. The effects of concomitant ions on the separation-preconcentration of analytes were also checked. The validation of the procedure was checked with addition recovery tests and analysis of Standard Reference Material 1570a-Trace Elements in Spinach Leaves and TMDA-70 fortified lake water Certified Reference Material. The LODs for analyte ions were in the range of 1.7-7.2 microg/L. The application of the present procedure was successfully performed for the analysis of analyte contents of herbal plant samples from Turkey.

  1. Rare-earth antisites in lutetium aluminum garnets: Influence on lattice parameter and Ce3+ multicenter structure

    NASA Astrophysics Data System (ADS)

    Przybylińska, H.; Wittlin, A.; Ma, Chong-Geng; Brik, M. G.; Kamińska, A.; Sybilski, P.; Zorenko, Yu.; Nikl, M.; Gorbenko, V.; Fedorov, A.; Kučera, M.; Suchocki, A.

    2014-07-01

    Low temperature, infrared transmission spectra of lutetium aluminum garnet (LuAG) bulk crystals and epitaxial layers doped with Ce are presented. In the region of intra-configurational 4f-4f transitions the spectra of the bulk LuAG crystal exhibit the signatures of several different Ce3+ related centers. Apart from the dominant center, associated with Ce substituting lutetium, at least six other centers are found, some of them attributed to so-called antisite locations of rare-earth ions in the garnet host, i.e., ions in the Al positions. X-ray diffraction data prove lattice expansion of bulk LuAG crystals due presence of rare-earth antisites.

  2. Features of the spectral dependences of transmittance of organic semiconductors based on tert-butyl substituted lutetium phthalocyanine molecules

    SciTech Connect

    Belogorokhov, I. A.; Tikhonov, E. V.; Dronov, M. A.; Belogorokhova, L. I.; Ryabchikov, Yu. V.; Tomilova, L. G.; Khokhlov, D. R.

    2011-11-15

    Vibronic properties of organic semiconductors based on tert-butyl substituted phthalocyanine lutetium diphthalocyanine molecules are studied by IR and Raman spectroscopy. It is shown that substitution of several carbon atoms in initial phthalocyanine (Pc) ligands with {sup 13}C isotope atoms causes a spectral shift in the main absorption lines attributed to benzene, isoindol, and peripheral C-H groups. A comparison of spectral characteristics showed that the shift can vary from 3 to 1 cm{sup -1}.

  3. A Study of the Physical and Mechanical Properties of Lutetium Compared with Those of Transition Metals: A Data Mining Approach

    NASA Astrophysics Data System (ADS)

    Settouti, Nadera; Aourag, Hafid

    2015-01-01

    In this article, we study the physical and mechanical properties of lutetium, which will be compared with the elements of the third-row transition metals (Cs, Ba, Hf, Ta, W, Re, Os, Ir, Pt, Au, Tl, Pb, and Bi). Data mining is an ideal approach for analyzing the information and exploring the hidden knowledge among the data. The purpose of the data mining scheme is to identify and classify the effects of the relationships existing between properties. The results of the investigation are presented by means of multivariate modeling methods, such as the principal component analysis and the partial least squares regression to discover the implicit, yet meaningful, relationship between the elements of the data set, and to locate correlations between the properties of the materials. In this study, we present a data mining approach to discover such unusual correlations between properties of the elements. When comparing the properties of the transition metals with those of lutetium, our results show that lutetium shares many properties and similarities with the transition metals of the sixth row in the periodic table and can be well described as a transition metal.

  4. Chemoradiation therapy using cyclopamine-loaded liquid-lipid nanoparticles and lutetium-177-labeled core-crosslinked polymeric micelles.

    PubMed

    You, Jian; Zhao, Jun; Wen, Xiaoxia; Wu, Chunhui; Huang, Qian; Guan, Fada; Wu, Richard; Liang, Dong; Li, Chun

    2015-03-28

    Cyclopamine (CPA), a potent inhibitor of the Hedgehog pathway, has produced promising anticancer results in a number of preclinical studies. CPA has also been found to enhance tumor response to radiation therapy. However, CPA is water insoluble. A drug delivery system suitable for systemic administration of CPA is needed before CPA can be considered for clinical translation. We hypothesized that CPA solubilized in a liquid-lipid nanoparticle system (CPA-LLP) for intravenous injection would have desirable pharmacokinetic properties and increased anticancer efficacy. We further hypothesized that CPA-LLP would enhance the response of tumor cells to targeted radiotherapy delivered selectively through intratumoral injection of lutetium-177 bound to core-crosslinked polymeric micelles (CCPM-(177)Lu). We tested the combination therapy in 4T1 murine breast cancer and Miapaca-2 human pancreatic adenocarcinoma models. The results showed that CPA-LLP had higher antitumor cytotoxicity than free CPA (IC50 values [mean±SEM]: 2.7±0.2μM vs. 11.3±1.2μM against 4T1 cells; 1.8±0.2 vs. 17.1±1.26μM against Miapaca-2 cells; p<0.0001). In both cell lines, CPA-LLP resulted in significantly lower clonogenicity than free CPA (p<0.05). Moreover, in both cell lines, CPA-LLP significantly enhanced the cell response to CCPM-(177)Lu radiotherapy as measured by clonogenic assay (p<0.05). In 4T1 and Miapaca-2 mouse xenograft models, the combination of CPA-LLP and CCPM-(177)Lu delayed tumor growth more than either monotherapy did alone. In the 4T1 tumor model, tumor size at 16days after treatment was significantly smaller with the combination therapy than with all the other treatments. In the Miapaca-2 model, the combination therapy resulted in the highest rate of mouse survival and prevented tumor relapse. In conclusion, the combination of CPA-LLP and CCPM-(177)Lu was an effective strategy for treating breast and pancreatic cancer and deserves further investigation.

  5. Beta emitters rhenium-188 and lutetium-177 are equally effective in radioimmunotherapy of HPV-positive experimental cervical cancer.

    PubMed

    Phaeton, Rebecca; Jiang, Zewei; Revskaya, Ekaterina; Fisher, Darrell R; Goldberg, Gary L; Dadachova, Ekaterina

    2016-01-01

    Cervical cancer caused by the infection with the human papillomavirus (HPV) remains the fourth leading killer of women worldwide. Therefore, more efficacious treatments are needed. We are developing radioimmunotherapy (RIT) of HPV-positive cervical cancers by targeting E6 and E7 viral oncoproteins expressed by the cancer cells with the radiolabeled monoclonal antibodies (mAbs). To investigate the influence of different radionuclides on the RIT efficacy-we performed RIT of experimental cervical cancer with Rhenium-188 ((188) Re) and Lutetium-177 ((177) Lu)-labeled mAb C1P5 to E6. The biodistribution of (188) Re- and (177) Lu-labeled C1P5 was performed in nude female mice bearing CasKi cervical cancer xenografts and the radiation dosimetry calculations for the tumors and organs were carried out. For RIT the mice were treated with 7.4 MBq of either (188) Re-C1P5 or (177) Lu-C1P5 or left untreated, and observed for their tumor size for 28 days. The levels of (188) Re- and (177) Lu-C1P5 mAbs-induced double-strand breaks in CasKi tumors were compared on days 5 and 10 post treatment by staining with anti-gamma H2AX antibody. The radiation doses to the heart and lungs were similar for both (177) Lu-C1P5 and (188) Re-C1P5. The dose to the liver was five times higher for (177) Lu-C1P5. The doses to the tumor were 259 and 181 cGy for (177) Lu-C1P5 and (188) Re-C1P5, respectively. RIT with either (177) Lu-C1P5 or (188) Re-C1P5 was equally effective in inhibiting tumor growth when each was compared to the untreated controls (P = 0.001). On day 5 there was a pronounced staining for gamma H2AX foci in (177) Lu-C1P5 group only and on day 10 it was observed in both (177) Lu-C1P5 and (188) Re-C1P5 groups. (188) Re- and (177) Lu-labeled mAbs were equally effective in arresting the growth of CasKi cervical tumors. Thus, both of these radionuclides are candidates for the clinical trials of this approach in patients with advanced, recurrent or metastatic cervical cancer.

  6. Development of a new bombesin analog radiolabeled with lutetium-177: in vivo evaluation of the biological properties in Balb-C mice.

    PubMed

    Pujatti, P B; Santos, J S; Massicano, A V F; Mengatti, J; De Araújo, E B

    2010-05-10

    In this work we describe the first results of radiolabeling with lutetium-177 ((177)Lu) and in vivo biodistribution and pharmacokinetics studies in normal Balb-c mice of a new bombesin analog (BEFG2)--DOTA-Phe-X-BBN(6-14), where X is a spacer of two aminoacids. Bombesin (BBN) is an amphibian analog of human gastrin releasing peptide (GRP). Development of radiolabeled BBN derivatives as agents for diagnostic imaging and systemic radiotherapy has increased considerable because of the observation that GRP receptors (GRPr) are over-expressed in a variety of human tumor cells, such as prostate tumor cells. (177)Lu-labeled peptides are attractive due to the excellent radiophysical properties and commercial availability of the radiometal. BEFG2 was successfully labeled with high yield and kept stable for more than 96 hours at 2-8 degrees C and 1 hour in human plasma. Data analysis obtained from the in vivo studies showed that the amount of BEFG2 present in plasma decreased rapidly and became almost undetectable at 60 min p.i., indicating rapid peptide excretion, which is performed mainly by renal pathway. In addition, biodistribution and single photon emission tomography showed low abdominal accumulation of (177)Lu-DOTA- Phe-X-BBN(6-14), indicating that this analog is a potential candidate for tumors target therapy.

  7. 46 CFR 160.176-7 - Independent laboratories.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 6 2013-10-01 2013-10-01 false Independent laboratories. 160.176-7 Section 160.176-7...: SPECIFICATIONS AND APPROVAL LIFESAVING EQUIPMENT Inflatable Lifejackets § 160.176-7 Independent laboratories. A list of independent laboratories which have been accepted by the Commandant for conducting...

  8. 46 CFR 160.176-7 - Independent laboratories.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 6 2012-10-01 2012-10-01 false Independent laboratories. 160.176-7 Section 160.176-7...: SPECIFICATIONS AND APPROVAL LIFESAVING EQUIPMENT Inflatable Lifejackets § 160.176-7 Independent laboratories. A list of independent laboratories which have been accepted by the Commandant for conducting...

  9. 46 CFR 160.176-7 - Independent laboratories.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 6 2010-10-01 2010-10-01 false Independent laboratories. 160.176-7 Section 160.176-7...: SPECIFICATIONS AND APPROVAL LIFESAVING EQUIPMENT Inflatable Lifejackets § 160.176-7 Independent laboratories. A list of independent laboratories which have been accepted by the Commandant for conducting...

  10. 46 CFR 160.176-7 - Independent laboratories.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 6 2011-10-01 2011-10-01 false Independent laboratories. 160.176-7 Section 160.176-7...: SPECIFICATIONS AND APPROVAL LIFESAVING EQUIPMENT Inflatable Lifejackets § 160.176-7 Independent laboratories. A list of independent laboratories which have been accepted by the Commandant for conducting...

  11. 46 CFR 160.176-7 - Independent laboratories.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 6 2014-10-01 2014-10-01 false Independent laboratories. 160.176-7 Section 160.176-7...: SPECIFICATIONS AND APPROVAL LIFESAVING EQUIPMENT Inflatable Lifejackets § 160.176-7 Independent laboratories. A list of independent laboratories which have been accepted by the Commandant for conducting...

  12. 46 CFR 176.925 - Safety Management Certificate.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Safety Management Certificate. 176.925 Section 176.925... TONS) INSPECTION AND CERTIFICATION International Convention for Safety of Life at Sea, 1974, as Amended (SOLAS) § 176.925 Safety Management Certificate. (a) All vessels that carry more than 12 passengers on...

  13. 46 CFR 160.176-5 - Approval procedures.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...) through 160.176-19(b)(4) and 160.176-19(d) of this part. (3) To conduct servicing at a remote or mobile... except that portable or mobile equipment must be available when evaluating the compliance with § 160.176... lifejacket that does not meet requirements in this subpart may still be approved if the device— (1)...

  14. 49 CFR 176.4 - Port security and safety regulations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Port security and safety regulations. 176.4 Section 176.4 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS... General § 176.4 Port security and safety regulations. (a) Each carrier, master, agent, and charterer of...

  15. 42 CFR 415.176 - Renal dialysis services.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false Renal dialysis services. 415.176 Section 415.176 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES... § 415.176 Renal dialysis services. In the case of renal dialysis services, physicians who are not...

  16. 42 CFR 415.176 - Renal dialysis services.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 3 2013-10-01 2013-10-01 false Renal dialysis services. 415.176 Section 415.176 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES... § 415.176 Renal dialysis services. In the case of renal dialysis services, physicians who are not...

  17. 42 CFR 415.176 - Renal dialysis services.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Renal dialysis services. 415.176 Section 415.176 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES... § 415.176 Renal dialysis services. In the case of renal dialysis services, physicians who are not...

  18. 21 CFR 176.350 - Tamarind seed kernel powder.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Tamarind seed kernel powder. 176.350 Section 176... Substances for Use Only as Components of Paper and Paperboard § 176.350 Tamarind seed kernel powder. Tamarind seed kernel powder may be safely used as a component of articles intended for use in...

  19. 40 CFR 176.15 - Effect of a tolerance.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 24 2014-07-01 2014-07-01 false Effect of a tolerance. 176.15 Section 176.15 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS TIME-LIMITED TOLERANCES FOR EMERGENCY EXEMPTIONS § 176.15 Effect of a tolerance. The establishment of...

  20. 40 CFR 176.15 - Effect of a tolerance.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 25 2013-07-01 2013-07-01 false Effect of a tolerance. 176.15 Section 176.15 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS TIME-LIMITED TOLERANCES FOR EMERGENCY EXEMPTIONS § 176.15 Effect of a tolerance. The establishment of...

  1. 40 CFR 176.15 - Effect of a tolerance.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 24 2011-07-01 2011-07-01 false Effect of a tolerance. 176.15 Section 176.15 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS TIME-LIMITED TOLERANCES FOR EMERGENCY EXEMPTIONS § 176.15 Effect of a tolerance. The establishment of...

  2. 40 CFR 176.15 - Effect of a tolerance.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 25 2012-07-01 2012-07-01 false Effect of a tolerance. 176.15 Section 176.15 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS TIME-LIMITED TOLERANCES FOR EMERGENCY EXEMPTIONS § 176.15 Effect of a tolerance. The establishment of...

  3. 40 CFR 176.15 - Effect of a tolerance.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Effect of a tolerance. 176.15 Section 176.15 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS TIME-LIMITED TOLERANCES FOR EMERGENCY EXEMPTIONS § 176.15 Effect of a tolerance. The establishment of...

  4. 46 CFR 176.640 - Pre-survey meeting.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Pre-survey meeting. 176.640 Section 176.640 Shipping...) INSPECTION AND CERTIFICATION Hull and Tailshaft Examinations § 176.640 Pre-survey meeting. (a) In advance of each AHE, you must conduct a pre-survey meeting to discuss the details of the AHE procedure with...

  5. 46 CFR 176.640 - Pre-survey meeting.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Pre-survey meeting. 176.640 Section 176.640 Shipping...) INSPECTION AND CERTIFICATION Hull and Tailshaft Examinations § 176.640 Pre-survey meeting. (a) In advance of each AHE, you must conduct a pre-survey meeting to discuss the details of the AHE procedure with...

  6. 46 CFR 176.640 - Pre-survey meeting.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Pre-survey meeting. 176.640 Section 176.640 Shipping...) INSPECTION AND CERTIFICATION Hull and Tailshaft Examinations § 176.640 Pre-survey meeting. (a) In advance of each AHE, you must conduct a pre-survey meeting to discuss the details of the AHE procedure with...

  7. 46 CFR 176.640 - Pre-survey meeting.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Pre-survey meeting. 176.640 Section 176.640 Shipping...) INSPECTION AND CERTIFICATION Hull and Tailshaft Examinations § 176.640 Pre-survey meeting. (a) In advance of each AHE, you must conduct a pre-survey meeting to discuss the details of the AHE procedure with...

  8. 46 CFR 176.640 - Pre-survey meeting.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Pre-survey meeting. 176.640 Section 176.640 Shipping...) INSPECTION AND CERTIFICATION Hull and Tailshaft Examinations § 176.640 Pre-survey meeting. (a) In advance of each AHE, you must conduct a pre-survey meeting to discuss the details of the AHE procedure with...

  9. 21 CFR 176.120 - Alkyl ketene dimers.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 3 2011-04-01 2011-04-01 false Alkyl ketene dimers. 176.120 Section 176.120 Food... Use Only as Components of Paper and Paperboard § 176.120 Alkyl ketene dimers. Alkyl ketene dimers may... section. (a) The alkyl ketene dimers are manufactured by the dehydrohalogenation of the acyl...

  10. 21 CFR 176.120 - Alkyl ketene dimers.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Alkyl ketene dimers. 176.120 Section 176.120 Food... Use Only as Components of Paper and Paperboard § 176.120 Alkyl ketene dimers. Alkyl ketene dimers may... section. (a) The alkyl ketene dimers are manufactured by the dehydrohalogenation of the acyl...

  11. 27 CFR 20.176 - Packaging by a dealer.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Packaging by a dealer. 20.176 Section 20.176 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU... and Users of Specially Denatured Spirits Operations by Dealers § 20.176 Packaging by a dealer....

  12. 49 CFR 176.150 - Radio and radar.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 2 2014-10-01 2014-10-01 false Radio and radar. 176.150 Section 176.150... Requirements for Class 1 (Explosive) Materials Precautions During Loading and Unloading § 176.150 Radio and... handled, the responsible person must ensure that all sources of electromagnetic radiation such as...

  13. 49 CFR 176.150 - Radio and radar.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Radio and radar. 176.150 Section 176.150... Requirements for Class 1 (Explosive) Materials Precautions During Loading and Unloading § 176.150 Radio and... as radio and radar transmitters are deenergized by opening the main switches controlling the...

  14. 49 CFR 176.150 - Radio and radar.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 2 2011-10-01 2011-10-01 false Radio and radar. 176.150 Section 176.150... Requirements for Class 1 (Explosive) Materials Precautions During Loading and Unloading § 176.150 Radio and... handled, the responsible person must ensure that all sources of electromagnetic radiation such as...

  15. 49 CFR 176.150 - Radio and radar.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 2 2012-10-01 2012-10-01 false Radio and radar. 176.150 Section 176.150... Requirements for Class 1 (Explosive) Materials Precautions During Loading and Unloading § 176.150 Radio and... handled, the responsible person must ensure that all sources of electromagnetic radiation such as...

  16. 49 CFR 176.150 - Radio and radar.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 2 2013-10-01 2013-10-01 false Radio and radar. 176.150 Section 176.150... Requirements for Class 1 (Explosive) Materials Precautions During Loading and Unloading § 176.150 Radio and... handled, the responsible person must ensure that all sources of electromagnetic radiation such as...

  17. 19 CFR 122.176 - Removal from ACSPP.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 1 2011-04-01 2011-04-01 false Removal from ACSPP. 122.176 Section 122.176 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY AIR COMMERCE REGULATIONS Air Carrier Smuggling Prevention Program § 122.176 Removal from ACSPP....

  18. 46 CFR 176.704 - Breaking of safety valve seals.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Breaking of safety valve seals. 176.704 Section 176.704... TONS) INSPECTION AND CERTIFICATION Repairs and Alterations § 176.704 Breaking of safety valve seals... the seal on a boiler safety valve on a vessel is broken....

  19. 46 CFR 176.704 - Breaking of safety valve seals.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Breaking of safety valve seals. 176.704 Section 176.704... TONS) INSPECTION AND CERTIFICATION Repairs and Alterations § 176.704 Breaking of safety valve seals... the seal on a boiler safety valve on a vessel is broken....

  20. 46 CFR 176.704 - Breaking of safety valve seals.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Breaking of safety valve seals. 176.704 Section 176.704... TONS) INSPECTION AND CERTIFICATION Repairs and Alterations § 176.704 Breaking of safety valve seals... the seal on a boiler safety valve on a vessel is broken....

  1. 46 CFR 176.704 - Breaking of safety valve seals.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Breaking of safety valve seals. 176.704 Section 176.704... TONS) INSPECTION AND CERTIFICATION Repairs and Alterations § 176.704 Breaking of safety valve seals... the seal on a boiler safety valve on a vessel is broken....

  2. 46 CFR 176.704 - Breaking of safety valve seals.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Breaking of safety valve seals. 176.704 Section 176.704... TONS) INSPECTION AND CERTIFICATION Repairs and Alterations § 176.704 Breaking of safety valve seals... the seal on a boiler safety valve on a vessel is broken....

  3. 21 CFR 176.320 - Sodium nitrate-urea complex.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 3 2013-04-01 2013-04-01 false Sodium nitrate-urea complex. 176.320 Section 176... Substances for Use Only as Components of Paper and Paperboard § 176.320 Sodium nitrate-urea complex. Sodium... the provisions of this section. (a) Sodium nitrate-urea complex is a clathrate of approximately...

  4. 21 CFR 176.320 - Sodium nitrate-urea complex.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 3 2014-04-01 2014-04-01 false Sodium nitrate-urea complex. 176.320 Section 176... Paperboard § 176.320 Sodium nitrate-urea complex. Sodium nitrate-urea complex may be safely used as a..., packaging, transporting, or holding food, subject to the provisions of this section. (a) Sodium...

  5. 49 CFR 176.225 - Stowage of chlorine.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 2 2014-10-01 2014-10-01 false Stowage of chlorine. 176.225 Section 176.225 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY... Requirements for Class 2 (Compressed Gas) Materials § 176.225 Stowage of chlorine. Chlorine (UN 1017) must...

  6. 49 CFR 176.225 - Stowage of chlorine.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 2 2012-10-01 2012-10-01 false Stowage of chlorine. 176.225 Section 176.225 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY... Requirements for Class 2 (Compressed Gas) Materials § 176.225 Stowage of chlorine. Chlorine (UN 1017) must...

  7. 49 CFR 176.225 - Stowage of chlorine.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 2 2011-10-01 2011-10-01 false Stowage of chlorine. 176.225 Section 176.225 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY... Requirements for Class 2 (Compressed Gas) Materials § 176.225 Stowage of chlorine. Chlorine (UN 1017) must...

  8. 49 CFR 176.225 - Stowage of chlorine.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 2 2013-10-01 2013-10-01 false Stowage of chlorine. 176.225 Section 176.225 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY... Requirements for Class 2 (Compressed Gas) Materials § 176.225 Stowage of chlorine. Chlorine (UN 1017) must...

  9. 49 CFR 176.225 - Stowage of chlorine.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Stowage of chlorine. 176.225 Section 176.225 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY... Requirements for Class 2 (Compressed Gas) Materials § 176.225 Stowage of chlorine. Chlorine (UN 1017) must...

  10. 28 CFR 35.176 - Alternative means of dispute resolution.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 1 2014-07-01 2014-07-01 false Alternative means of dispute resolution. 35.176 Section 35.176 Judicial Administration DEPARTMENT OF JUSTICE NONDISCRIMINATION ON THE BASIS OF DISABILITY IN STATE AND LOCAL GOVERNMENT SERVICES Compliance Procedures § 35.176 Alternative means of...

  11. 28 CFR 35.176 - Alternative means of dispute resolution.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 1 2013-07-01 2013-07-01 false Alternative means of dispute resolution. 35.176 Section 35.176 Judicial Administration DEPARTMENT OF JUSTICE NONDISCRIMINATION ON THE BASIS OF DISABILITY IN STATE AND LOCAL GOVERNMENT SERVICES Compliance Procedures § 35.176 Alternative means of...

  12. 28 CFR 35.176 - Alternative means of dispute resolution.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Alternative means of dispute resolution. 35.176 Section 35.176 Judicial Administration DEPARTMENT OF JUSTICE NONDISCRIMINATION ON THE BASIS OF DISABILITY IN STATE AND LOCAL GOVERNMENT SERVICES Compliance Procedures § 35.176 Alternative means of...

  13. 46 CFR 176.812 - Pressure vessels and boilers.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Pressure vessels and boilers. 176.812 Section 176.812... TONS) INSPECTION AND CERTIFICATION Material Inspections § 176.812 Pressure vessels and boilers. (a) Pressure vessels must be tested and inspected in accordance with part 61, subpart 61.10, of this...

  14. 46 CFR 176.812 - Pressure vessels and boilers.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Pressure vessels and boilers. 176.812 Section 176.812... TONS) INSPECTION AND CERTIFICATION Material Inspections § 176.812 Pressure vessels and boilers. (a) Pressure vessels must be tested and inspected in accordance with part 61, subpart 61.10, of this...

  15. 46 CFR 176.812 - Pressure vessels and boilers.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Pressure vessels and boilers. 176.812 Section 176.812... TONS) INSPECTION AND CERTIFICATION Material Inspections § 176.812 Pressure vessels and boilers. (a) Pressure vessels must be tested and inspected in accordance with part 61, subpart 61.10, of this...

  16. 46 CFR 176.812 - Pressure vessels and boilers.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Pressure vessels and boilers. 176.812 Section 176.812... TONS) INSPECTION AND CERTIFICATION Material Inspections § 176.812 Pressure vessels and boilers. (a) Pressure vessels must be tested and inspected in accordance with part 61, subpart 61.10, of this...

  17. 46 CFR 176.812 - Pressure vessels and boilers.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Pressure vessels and boilers. 176.812 Section 176.812... TONS) INSPECTION AND CERTIFICATION Material Inspections § 176.812 Pressure vessels and boilers. (a) Pressure vessels must be tested and inspected in accordance with part 61, subpart 61.10, of this...

  18. 50 CFR 17.6 - State cooperative agreements. [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 2 2012-10-01 2012-10-01 false State cooperative agreements. 17.6 Section 17.6 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR... Provisions § 17.6 State cooperative agreements....

  19. 50 CFR 17.6 - State cooperative agreements. [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 2 2011-10-01 2011-10-01 false State cooperative agreements. 17.6 Section 17.6 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR... Provisions § 17.6 State cooperative agreements....

  20. 28 CFR 115.176 - Disciplinary sanctions for staff.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Disciplinary sanctions for staff. 115.176 Section 115.176 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PRISON RAPE ELIMINATION ACT NATIONAL STANDARDS Standards for Lockups Discipline § 115.176 Disciplinary sanctions for staff. (a)...

  1. 28 CFR 115.176 - Disciplinary sanctions for staff.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Disciplinary sanctions for staff. 115.176 Section 115.176 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PRISON RAPE ELIMINATION ACT NATIONAL STANDARDS Standards for Lockups Discipline § 115.176 Disciplinary sanctions for staff. (a)...

  2. 28 CFR 115.176 - Disciplinary sanctions for staff.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 2 2014-07-01 2014-07-01 false Disciplinary sanctions for staff. 115.176 Section 115.176 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PRISON RAPE ELIMINATION ACT NATIONAL STANDARDS Standards for Lockups Discipline § 115.176 Disciplinary sanctions for staff. (a)...

  3. 49 CFR 176.7 - Documentation for vessel personnel.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Documentation for vessel personnel. 176.7 Section 176.7 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS... General § 176.7 Documentation for vessel personnel. Each owner, operator, master, agent, person in...

  4. 21 CFR 176.260 - Pulp from reclaimed fiber.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 3 2011-04-01 2011-04-01 false Pulp from reclaimed fiber. 176.260 Section 176.260... for Use Only as Components of Paper and Paperboard § 176.260 Pulp from reclaimed fiber. (a) Pulp from reclaimed fiber may be safely used as a component of articles used in producing, manufacturing,...

  5. 21 CFR 176.260 - Pulp from reclaimed fiber.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Pulp from reclaimed fiber. 176.260 Section 176.260... for Use Only as Components of Paper and Paperboard § 176.260 Pulp from reclaimed fiber. (a) Pulp from reclaimed fiber may be safely used as a component of articles used in producing, manufacturing,...

  6. 49 CFR 176.3 - Unacceptable hazardous materials shipments.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Unacceptable hazardous materials shipments. 176.3 Section 176.3 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS REGULATIONS CARRIAGE BY VESSEL General § 176.3 Unacceptable...

  7. 49 CFR 176.96 - Materials of construction.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Materials of construction. 176.96 Section 176.96 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS REGULATIONS CARRIAGE BY VESSEL Special Requirements for Barges § 176.96 Materials...

  8. 46 CFR 160.176-17 - Manufacturer records.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 6 2010-10-01 2010-10-01 false Manufacturer records. 160.176-17 Section 160.176-17...: SPECIFICATIONS AND APPROVAL LIFESAVING EQUIPMENT Inflatable Lifejackets § 160.176-17 Manufacturer records. (a) Each manufacturer of inflatable lifejackets must keep the records required by § 159.007-13 of...

  9. 46 CFR 176.910 - Passenger Ship Safety Certificate.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Passenger Ship Safety Certificate. 176.910 Section 176..., as Amended (SOLAS) § 176.910 Passenger Ship Safety Certificate. (a) A vessel, which carries more than 12 passengers on an international voyage must have a valid SOLAS Passenger Ship Safety...

  10. 46 CFR 176.910 - Passenger Ship Safety Certificate.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Passenger Ship Safety Certificate. 176.910 Section 176..., as Amended (SOLAS) § 176.910 Passenger Ship Safety Certificate. (a) A vessel, which carries more than 12 passengers on an international voyage must have a valid SOLAS Passenger Ship Safety...

  11. 46 CFR 176.910 - Passenger Ship Safety Certificate.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Passenger Ship Safety Certificate. 176.910 Section 176..., as Amended (SOLAS) § 176.910 Passenger Ship Safety Certificate. (a) A vessel, which carries more than 12 passengers on an international voyage must have a valid SOLAS Passenger Ship Safety...

  12. 46 CFR 176.910 - Passenger Ship Safety Certificate.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Passenger Ship Safety Certificate. 176.910 Section 176..., as Amended (SOLAS) § 176.910 Passenger Ship Safety Certificate. (a) A vessel, which carries more than 12 passengers on an international voyage must have a valid SOLAS Passenger Ship Safety...

  13. 46 CFR 176.910 - Passenger Ship Safety Certificate.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Passenger Ship Safety Certificate. 176.910 Section 176..., as Amended (SOLAS) § 176.910 Passenger Ship Safety Certificate. (a) A vessel, which carries more than 12 passengers on an international voyage must have a valid SOLAS Passenger Ship Safety...

  14. 49 CFR 176.320 - Use of hand flashlights.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 2 2011-10-01 2011-10-01 false Use of hand flashlights. 176.320 Section 176.320... Requirements for Class 3 (Flammable) and Combustible Liquid Materials § 176.320 Use of hand flashlights. Each hand flashlight used on deck near or in any hold or compartment containing a Class 3 (flammable)...

  15. 49 CFR 176.320 - Use of hand flashlights.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 2 2012-10-01 2012-10-01 false Use of hand flashlights. 176.320 Section 176.320... Requirements for Class 3 (Flammable) and Combustible Liquid Materials § 176.320 Use of hand flashlights. Each hand flashlight used on deck near or in any hold or compartment containing a Class 3 (flammable)...

  16. 49 CFR 176.320 - Use of hand flashlights.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 2 2014-10-01 2014-10-01 false Use of hand flashlights. 176.320 Section 176.320... Requirements for Class 3 (Flammable) and Combustible Liquid Materials § 176.320 Use of hand flashlights. Each hand flashlight used on deck near or in any hold or compartment containing a Class 3 (flammable)...

  17. 49 CFR 176.320 - Use of hand flashlights.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 2 2013-10-01 2013-10-01 false Use of hand flashlights. 176.320 Section 176.320... Requirements for Class 3 (Flammable) and Combustible Liquid Materials § 176.320 Use of hand flashlights. Each hand flashlight used on deck near or in any hold or compartment containing a Class 3 (flammable)...

  18. 49 CFR 176.320 - Use of hand flashlights.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Use of hand flashlights. 176.320 Section 176.320... Requirements for Class 3 (Flammable) and Combustible Liquid Materials § 176.320 Use of hand flashlights. Each hand flashlight used on deck near or in any hold or compartment containing a Class 3 (flammable)...

  19. 49 CFR 176.405 - Stowage of charcoal.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 2 2011-10-01 2011-10-01 false Stowage of charcoal. 176.405 Section 176.405... Materials § 176.405 Stowage of charcoal. (a) Before stowing charcoal Division 4.2 (flammable solid), UN 1361... petroleum product, a vegetable or animal oil, nitrate, or sulfur, must be removed. (b) Charcoal packed...

  20. 49 CFR 176.405 - Stowage of charcoal.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 2 2013-10-01 2013-10-01 false Stowage of charcoal. 176.405 Section 176.405... Materials § 176.405 Stowage of charcoal. (a) Before stowing charcoal Division 4.2 (flammable solid), UN 1361... petroleum product, a vegetable or animal oil, nitrate, or sulfur, must be removed. (b) Charcoal packed...

  1. 49 CFR 176.405 - Stowage of charcoal.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 2 2014-10-01 2014-10-01 false Stowage of charcoal. 176.405 Section 176.405... Materials § 176.405 Stowage of charcoal. (a) Before stowing charcoal Division 4.2 (flammable solid), UN 1361... petroleum product, a vegetable or animal oil, nitrate, or sulfur, must be removed. (b) Charcoal packed...

  2. 49 CFR 176.405 - Stowage of charcoal.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Stowage of charcoal. 176.405 Section 176.405... Materials § 176.405 Stowage of charcoal. (a) Before stowing charcoal Division 4.2 (flammable solid), UN 1361... petroleum product, a vegetable or animal oil, nitrate, or sulfur, must be removed. (b) Charcoal packed...

  3. 49 CFR 176.405 - Stowage of charcoal.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 2 2012-10-01 2012-10-01 false Stowage of charcoal. 176.405 Section 176.405... Materials § 176.405 Stowage of charcoal. (a) Before stowing charcoal Division 4.2 (flammable solid), UN 1361... petroleum product, a vegetable or animal oil, nitrate, or sulfur, must be removed. (b) Charcoal packed...

  4. 21 CFR 161.176 - Frozen raw lightly breaded shrimp.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Frozen raw lightly breaded shrimp. 161.176 Section 161.176 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES... Shellfish § 161.176 Frozen raw lightly breaded shrimp. Frozen raw lightly breaded shrimp complies with...

  5. 21 CFR 176.320 - Sodium nitrate-urea complex.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Sodium nitrate-urea complex. 176.320 Section 176... Substances for Use Only as Components of Paper and Paperboard § 176.320 Sodium nitrate-urea complex. Sodium nitrate-urea complex may be safely used as a component of articles intended for use in...

  6. 21 CFR 176.320 - Sodium nitrate-urea complex.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 3 2011-04-01 2011-04-01 false Sodium nitrate-urea complex. 176.320 Section 176... Substances for Use Only as Components of Paper and Paperboard § 176.320 Sodium nitrate-urea complex. Sodium nitrate-urea complex may be safely used as a component of articles intended for use in...

  7. 21 CFR 176.320 - Sodium nitrate-urea complex.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 3 2012-04-01 2012-04-01 false Sodium nitrate-urea complex. 176.320 Section 176... Substances for Use Only as Components of Paper and Paperboard § 176.320 Sodium nitrate-urea complex. Sodium nitrate-urea complex may be safely used as a component of articles intended for use in...

  8. 46 CFR 160.176-21 - User manuals.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 6 2010-10-01 2010-10-01 false User manuals. 160.176-21 Section 160.176-21 Shipping...: SPECIFICATIONS AND APPROVAL LIFESAVING EQUIPMENT Inflatable Lifejackets § 160.176-21 User manuals. (a) The manufacturer must develop a user's manual for each model of inflatable lifejacket. The content of the...

  9. 10 CFR 431.171-431.176 - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 3 2012-01-01 2012-01-01 false 431.171-431.176 Section 431.171-431.176 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY EFFICIENCY PROGRAM FOR CERTAIN COMMERCIAL AND INDUSTRIAL EQUIPMENT Reserved §§ 431.171-431.176...

  10. 10 CFR 431.171-431.176 - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 3 2013-01-01 2013-01-01 false 431.171-431.176 Section 431.171-431.176 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY EFFICIENCY PROGRAM FOR CERTAIN COMMERCIAL AND INDUSTRIAL EQUIPMENT Reserved §§ 431.171-431.176...

  11. 10 CFR 431.171-431.176 - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 3 2014-01-01 2014-01-01 false 431.171-431.176 Section 431.171-431.176 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY EFFICIENCY PROGRAM FOR CERTAIN COMMERCIAL AND INDUSTRIAL EQUIPMENT Reserved §§ 431.171-431.176...

  12. 21 CFR 176.110 - Acrylamide-acrylic acid resins.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Acrylamide-acrylic acid resins. 176.110 Section 176... Substances for Use Only as Components of Paper and Paperboard § 176.110 Acrylamide-acrylic acid resins. Acrylamide-acrylic acid resins may be safely used as components of articles intended for use in...

  13. 46 CFR 176.105 - How to obtain or renew.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false How to obtain or renew. 176.105 Section 176.105 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) INSPECTION AND CERTIFICATION Certificate of Inspection § 176.105 How to obtain or renew. (a) A Certificate...

  14. 49 CFR 176.315 - Fire protection requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 2 2014-10-01 2014-10-01 false Fire protection requirements. 176.315 Section 176... Detailed Requirements for Class 3 (Flammable) and Combustible Liquid Materials § 176.315 Fire protection... combustible liquid being transported on board a vessel in a portable tank, rail tank car, or a motor...

  15. Physical properties of zircon and scheelite lutetium orthovanadate: Experiment and first-principles calculation

    SciTech Connect

    Huang, Zuocai; Zhang, Lei; Pan, Wei

    2013-09-15

    Pure zircon and scheelite LuVO{sub 4} were prepared by solid state reaction and high-pressure route, respectively. Structure, elastic constants, lattice dynamics and thermodynamics of LuVO{sub 4} polymorphs were studied by experiments and first principles calculation. Calculations here are in good agreement with the experimental results. The phonon dispersions of LuVO{sub 4} polymorphs were studied by the linear response method. The calculated phonon dispersions show that zircon and scheelite LuVO{sub 4} phases are dynamically stable. Raman-active frequencies were measured and assigned to different modes according to the calculations. The internal frequencies shift downward after phase transition from zircon to scheelite. Born effective charge tensors elements for both phases are analyzed. The finite temperature thermodynamic properties of LuVO{sub 4} polymorphs were calculated from the obtained phonon density of states by quasi-harmonic approach. - Graphical abstract: Lutetium orthovanadate polymorphs were synthesized by SSR and HP methods and their physical and chemical properties, including lattice dynamical properties, were determined by DFT calculations and experiments. Display Omitted - Highlights: • Pure zircon and scheelite LuVO{sub 4} polymorphs were synthesized by solid state reaction and high-pressure route. • Chemical and physical properties of LuVO4 polymorphs were studied by experiments and first principles calculation. • Raman-active frequencies were measured and assigned to different modes according to the calculations. • Lattice dynamics of polymorphs were discussed in details.

  16. Lutetium speciation and toxicity in a microbial bioassay: testing the free-ion model for lanthanides.

    PubMed

    Weltje, Lennart; Verhoof, Lars R C W; Verweij, Wilko; Hamers, Timo

    2004-12-15

    The validity of the free-ion model (FIM) for the element lutetium (Lu), a member of the lanthanides, was assessed in experiments with the bacterium Vibrio fischeri. The FIM is mainly based on divalent metals and synthetic ligands and has not yet been validated for the trivalent lanthanides. The bioluminescence response of V. fischeri was studied at different Lu concentrations in the presence and absence of natural and synthetic organic ligands [citrate, malate, oxalate, acetate, ethylenediaminetetraacetate (EDTA), and nitrilotriacetate (NTA)]. All ligands were tested separately to ensure that their concentrations would not cause adverse effects themselves. Free Lu3+ concentrations were calculated with a speciation program, after extension of its database with the relevant Lu equilibria. The results confirmed the FIM for Lu: that is, in contrast to total dissolved Lu concentrations, free Lu3+ concentrations had an apparent relationship with the response of V. fischeri. However, a contribution of minor inorganic Lu complexes cannot be ruled out. In the presence of malate and oxalate, the EC50 for Lu3+ decreased faster in time than for the other ligands, indicating lower elimination rates. With an EC50 of 1.57 microM, Lu3+ is more toxic than La3+, Cd2+, or Zn2+ and approximately equally as toxic as Cu2+. Although the pH increased slightly during the experiments, it was shown that the influence of pH on Lu speciation was limited.

  17. Volatile organic compounds sensing properties of tetrakis(alkylthio)-substituted lutetium(III) bisphthalocyanines thin films.

    PubMed

    Kilinç, Necmettin; Atilla, Devrim; Gürek, Ayşe Gül; Oztürk, Zafer Ziya; Ahsen, Vefa

    2009-11-15

    The effect of volatile organic compounds (VOCs) such as acetone, methanol, ethanol, chloroform, carbon tetrachloride, dichloromethane, and hexane on electrical conductivity of thin films of bis[tetrakis(alkylthio)phthalocyaninato]lutetium(III) double decker complexes [(C(n)H(2n+1)S)(4)Pc](2)Lu(III) was investigated. The [(C(n)H(2n+1)S)(4)Pc](2)Lu(III) molecules substituted with different alkylthia chains (n=6, 8, 10, 12, and 16) were coated on interdigital transducers using a jet spray technique. A change (increase or decrease) in the conductivity of the [(C(n)H(2n+1)S)(4)Pc](2)Lu(III) films was observed depending on the concentration of the VOCs, which was ranging from 500 to 5000 ppm. The decrease in the conductivity of the sensors for the dissolvent of the compounds (chloroform, carbon tetrachloride, dichloromethane and hexane) could be related to swelling of the films. On the other hand, the increase in the conductivity of the sensors for the other VOCs (acetone, methanol and ethanol) could be resulted from that the VOCs act as electron donors and/or acceptors in the films. A linear relationship between the sensor response and concentration of the VOC vapors is obtained. The sensitivities of the [(C(n)H(2n+1)S)(4)Pc](2)Lu(III) films were in the range of 2.10(-4)-3.10(-3)%/ppm.

  18. Lutetium 177-DOTA-TATE therapy for esthesioneuroblastoma: A case report.

    PubMed

    Sabongi, Juliano Guerra; Gonçalves, Mônica Carboni Pereira; Alves, Cira Danielle Casado; Alves, João; Scapulatempo-Neto, Cristovam; Moriguchi, Sonia Marta

    2016-11-01

    Esthesioneuroblastoma (ENB), also known as olfactory neuroblastoma, is a rare malignant tumor that accounts for 3% of all tumors of the nasal cavity. The incidence of ENB is 0.4 cases per million in the general population, and the most common symptoms are nasal obstruction and epistaxis. Previous studies have indicated the presence of somatostatin receptors in this tumor type. Common treatment strategies for ENB include resection and adjuvant radiotherapy and/or chemotherapy (combined treatment); however, the rate of recurrence is high. Treatment of neuroendocrine tumors using radionuclides bound to somatostatin analogues is well established in clinical practice. However, a standard and effective therapeutic approach has not been reported for ENB. The current study described the case of a 74-year-old female with numerous recurrences of ENB following multiple treatments and without possibility of resection. The patient was treated with the radiolabeled-somatostatin analogue, (177)Lutetium-DOTA-octreotate ((177)Lu-DOTA-TATE), which successfully controlled the disease. This suggests that (177)Lu-DOTA-TATE is a potential treatment for ENB and may represent an effective alternative and novel therapeutic strategy for this disease.

  19. The melting behavior of lutetium aluminum perovskite LuAlO3

    NASA Astrophysics Data System (ADS)

    Klimm, Detlef

    2010-02-01

    DTA measurements with mixtures of aluminum oxide and lutetium oxide around the 1:1 perovskite composition were performed up to 1970C. A peak with onset 1901C was due to the melting of the eutectic Lu4Al2O9 (monoclinic phase) and LuAlO3 (perovskite). Neither peritectic melting of the perovskite nor its decomposition in the solid phase could be resolved experimentally. The maximum of the eutectic peak size is near x=0.44, on the Lu-rich side of the perovskite, which is consistent with the conclusion that LuAlO3 melts peritectically at ca. 1907C as proposed by Wu, Pelton, J. Alloys Compd. 179 (1992) 259. Thermodynamic equilibrium calculation reveals that under strongly reducing conditions (oxygen partial pressure <10-13 bar) aluminum(III) oxide can be reduced to suboxides or even Al metal. It is shown that under such conditions a new phase field with liquid Al can appear.

  20. Lutetium 177-DOTA-TATE therapy for esthesioneuroblastoma: A case report

    PubMed Central

    Sabongi, Juliano Guerra; Gonçalves, Mônica Carboni Pereira; Alves, Cira Danielle Casado; Alves, João; Scapulatempo-Neto, Cristovam; Moriguchi, Sonia Marta

    2016-01-01

    Esthesioneuroblastoma (ENB), also known as olfactory neuroblastoma, is a rare malignant tumor that accounts for 3% of all tumors of the nasal cavity. The incidence of ENB is 0.4 cases per million in the general population, and the most common symptoms are nasal obstruction and epistaxis. Previous studies have indicated the presence of somatostatin receptors in this tumor type. Common treatment strategies for ENB include resection and adjuvant radiotherapy and/or chemotherapy (combined treatment); however, the rate of recurrence is high. Treatment of neuroendocrine tumors using radionuclides bound to somatostatin analogues is well established in clinical practice. However, a standard and effective therapeutic approach has not been reported for ENB. The current study described the case of a 74-year-old female with numerous recurrences of ENB following multiple treatments and without possibility of resection. The patient was treated with the radiolabeled-somatostatin analogue, 177Lutetium-DOTA-octreotate (177Lu-DOTA-TATE), which successfully controlled the disease. This suggests that 177Lu-DOTA-TATE is a potential treatment for ENB and may represent an effective alternative and novel therapeutic strategy for this disease. PMID:27882120

  1. Structural and electrochemical properties of lutetium bis-octachloro-phthalocyaninate nanostructured films. Application as voltammetric sensors.

    PubMed

    Alessio, P; Apetrei, C; Rubira, R J G; Constantino, C J L; Medina-Plazal, C; De Saja, J A; Rodríguez-Méndez, M L

    2014-09-01

    Thin films of the bis[2,3,9,10,16,17,23,24-octachlorophthalocyaninate] lutetium(III) complex (LuPc2Cl32) have been prepared by the Langmuir-Blodgett and the Langmuir-Schaefer (LS) techniques. The influence of the chlorine substituents in the structure of the films and in their spectroscopic, electrochemical and sensing properties has been evaluated. The π-A isotherms exhibit a monolayer stability greater than the observed in the unsubstituted analogue (LuPc2), being easily transferred to solid substrates, also in contrast to LuPc2. The LB and LS films present a linear growth forming stratified layers, monitored by UV-VIS absorption spectroscopy. The latter also revealed the presence of LuPc2Cl32 in the form of monomers and aggregates in both films. The FTIR data showed that the LuPc2Cl32 molecules present a non-preferential arrangement in both films. Monolayers of LB and LS were deposited onto 6 nm Ag island films to record surface-enhanced resonance Raman scattering (SERRS), leading to enhancement factors close to 2 x 10(3). Finally, LB and LS films deposited onto ITO glass have been successfully used as voltammetric sensors for the detection of catechol. The improved electroactivity of the LB and LS films has been confirmed by the reduction of the overpotential of the oxidation of catechol. The enhancement of the electrocatalytic effect observed in LB and LS films is the result of the nanostructured arrangement of the surface which increases the number of active sites. The sensors show a limit of detection in the range of 10(-5) mol/L.

  2. Lutetium(III)-dependent self-assembly study of ciliate Euplotes octocarinatus centrin.

    PubMed

    Duan, Lian; Zhao, Ya-Qin; Wang, Zhi-Jun; Li, Guo-Ting; Liang, Ai-Hua; Yang, Bin-Sheng

    2008-02-01

    Ciliate Euplotes octocarinatus centrin (EoCen) is a member of the EF-hand superfamily of calcium-binding proteins, which often associated with the centrosomes and basal bodies. To explore the possible structural role of EoCen, we initiated a physicochemical study of the self-assembly properties of the purified protein in vitro. The native PAGE results indicate that only the integral protein shows multimers in the presence of Lu(3+). The dependence of Lu(3+) induced self-assembly of EoCen on various chemical and physical factors, including temperature, protein concentration, ionic strength and pH, was characterized using resonance light scattering (RLS). Control experiments with different metal ions suggest that Ca(2+) and Lu(3+) bindings to the N-terminal domain of EoCen are all positive to the self-assembly of the protein, and Lu(3+) exhibits the stronger effect, however, Mg(2+) alone cannot take the same effect. The experiments of 2-ptoluidinylnaphthalene-6-sulfonate (TNS) binding and ionic strength demonstrate that the lutetium(III)-dependent self-assembly is closely related to the exposure of hydrophobic cavity. Control experiment on pH value with EoCen and the fragments of it, N-terminal domain of EoCen (N-EoCen), indicates that the electrostatic effect is of small tendency to be served as the main driving force in the self-assembly of EoCen. The specific oligomerization form of the protein was exhibited by cross-linking experiment.

  3. Motexafin lutetium-photodynamic therapy of prostate cancer: Short and long term effects on PSA

    PubMed Central

    Patel, Hiral; Mick, Rosemarie; Finlay, Jarod; Zhu, Timothy C.; Rickter, Elizabeth; Cengel, Keith A.; Malkowicz, S. Bruce; Hahn, Stephen M.; Busch, Theresa M.

    2009-01-01

    Purpose: The time course of serum PSA response to photodynamic therapy (PDT) of prostate cancer was measured. Experimental Design: Seventeen patients were treated in a Phase I trial of motexafin lutetium-PDT. PDT dose was calculated in each patient as the product of the ex vivo-measured pre-PDT photosensitizer level and the in situ-measured light dose. Serum PSA level was measured within two months prior to PDT (baseline), and at day 1; weeks 1-3; months 1, 2 and 3; months 4-6 and months 7-11 after PDT. Results: At 24h after PDT, serum PSA increased by 98±36% (mean ± SE) relative to baseline levels (p=0.007). When patients were dichotomized based on median PDT dose, those who received high PDT dose demonstrated a 119±52% increase in PSA compared to a 54±27% increase in patients treated at low PDT dose. Patients treated with high vs. low PDT dose demonstrated a median biochemical delay of 82 vs. 43 days (p=0.024), with biochemical delay defined as the length of time between PDT and a nonreversible increase in PSA to a value ≥baseline. Conclusions: Results show PDT to induce large, transient increases in serum PSA levels. Patients who experienced high PDT dose demonstrated greater short-term increase in PSA and a significantly more durable PSA response (biochemical delay). These data strongly promote the need for individualized delivery of PDT dose and assessment of treatment effect in PDT of prostate cancer. Information gained from such patient-specific measurements could facilitate the introduction of multiple PDT sessions in patients who would benefit. PMID:18676760

  4. Investigation of high pressure phase transition and electronic properties of Lutetium Nitride

    NASA Astrophysics Data System (ADS)

    Singh, Sanjay Kumar; Verma, U. P.

    2015-09-01

    In the present manuscript we have investigated the structural, electronic and phase transition properties of the heaviest lanthanide lutetium nitride (LuN) compound using an ab initio calculations based on the density functional theory with Perdrew, Burke and Ernzerhof generalized gradient approximation (PBE-GGA) and Engel-Vosko(EV)-GGA as implemented in WIEN2k code. The basic ground state properties viz., lattice constants (a), bulk modulus (B0) and its pressure derivative (B0’) and total energy (E0) are calculated. The calculated values of lattice constant is 4.76 Å which is in good agreement with experimental value a= 4.76 A and other theoretical value. The relative stabilities of LuN at high pressures in the NaCl (B1), CsCl (B2), zinc blende (B3) and body centred tetragonal (BCT) structures are analysed. At compressed volumes, this compound is found to favour the CsCl phase rather the body centred tetragonal phase and zinc blende as observed in other lanthanum pnictides, which has been predicted by the total energy minimization. Under compression LuN undergoes a transition from NaCl to CsCl type structure at around 250.81 GPa with a volume collapse of 3.75%. To see the effect of functional we have also computed the band structure in B1 and B2 structure. Obtained result on band structure shows that LuN are semimetal by GGA while depicts semiconducting behaviour by EV-GGA. It shows metallic nature in B2 phase.

  5. Piano-Stool Lutetium Amido and Imido Compounds Supported by a Constrained Bis(oxazoline)cyclopentadienyl Ligand.

    PubMed

    Lampland, Nicole L; Zhu, Jing; Hovey, Megan; Jana, Barun; Ellern, Arkady; Sadow, Aaron D

    2015-07-20

    {Bo(M)Cp(tet)}Lu(CH2Ph)2 (1; Bo(M)Cp(tet) = MeC(Ox(Me2))2C5Me4; Ox(Me2) = 4,4-dimethyl-2-oxazoline) was prepared in 95% yield from the reaction of Bo(M)Cp(tet)H and Lu(CH2Ph)3THF3. Compound 1 reacts with 1 or 2 equiv of H2NCH2R (R = C6H5, 1-C10H7) to give the corresponding imido complexes [{Bo(M)Cp(tet)}LuNCH2R]2 (R = C6H5 (2a), 1-C10H7 (2b)) or amido complexes {Bo(M)Cp(tet)}Lu(NHCH2R)2 (R = C6H5 (3a), 1-C10H7 (3b)). Once isolated, the imido species are insoluble in nonprotic organic solvents. Crystallographic characterization reveals dimeric [{Bo(M)Cp(tet)}LuNCH2(1-C10H7)]2 in the solid state. The reaction of 1 and NH3B(C6F5)3 affords crystallographically characterized {Bo(M)Cp(tet)}Lu{NHB(C6F5)2}C6F5. This species is proposed to form via a transient lutetium imido, which undergoes C6F5 migration to the lutetium center.

  6. High-phasing-power lanthanide derivatives: taking advantage of ytterbium and lutetium for optimized anomalous diffraction experiments using synchrotron radiation.

    PubMed

    Girard, E; Anelli, P L; Vicat, J; Kahn, R

    2003-10-01

    Ytterbium and lutetium are well suited for optimized anomalous diffraction experiments using synchrotron radiation. Therefore, two lanthanide complexes Yb-HPDO3A and Lu-HPDO3A have been produced that are similar to the Gd-HPDO3A complex already known to give good derivative crystals. Derivative crystals of hen egg-white lysozyme were obtained by co-crystallization using 100 mM solutions of each lanthanide complex. De novo phasing has been carried out using single-wavelength anomalous diffraction on data sets collected on each derivative crystal at the L(III) absorption edge of the corresponding lanthanide (ff" = 28 e(-)). A third data set was collected on a Lu-HPDO3A derivative crystal at the Se K absorption edge with f"(Lu) = 10 e(-). The structures were refined and compared with the known structure of the Gd-HPDO3A lysozyme derivative. The quality of the experimental electron-density maps allows easy model building. With L(III) absorption edges at shorter wavelengths than the gadolinium absorption edge, lutetium and ytterbium, when chelated by a ligand such as HPDO3A, form lanthanide complexes that are especially interesting for synchrotron-radiation experiments in structural biology.

  7. Anti-biofouling polymer-decorated lutetium-based nanoparticulate contrast agents for in vivo high-resolution trimodal imaging.

    PubMed

    Liu, Zhen; Dong, Kai; Liu, Jianhua; Han, Xueli; Ren, Jinsong; Qu, Xiaogang

    2014-06-25

    Nanomaterials have gained considerable attention and interest in the development of novel and high-resolution contrast agents for medical diagnosis and prognosis in clinic. A classical urea-based homogeneous precipitation route that combines the merits of in situ thermal decomposition and surface modification is introduced to construct polyethylene glycol molecule (PEG)-decorated hybrid lutetium oxide nanoparticles (PEG-UCNPs). By utilizing the admirable optical and magnetic properties of the yielded PEG-UCNPs, in vivo up-conversion luminescence and T1 -enhanced magnetic resonance imaging of small animals are conducted, revealing obvious signals after subcutaneous and intravenous injection, respectively. Due to the strong X-ray absorption and high atomic number of lanthanide elements, X-ray computed-tomography imaging based on PEG-UCNPs is then designed and carried out, achieving excellent imaging outcome in animal experiments. This is the first example of the usage of hybrid lutetium oxide nanoparticles as effective nanoprobes. Furthermore, biodistribution, clearance route, as well as long-term toxicity are investigated in detail after intravenous injection in a murine model, indicating the overall safety of PEG-UCNPs. Compared with previous lanthanide fluorides, our nanoprobes exhibit more advantages, such as facile construction process and nearly total excretion from the animal body within a month. Taken together, these results promise the use of PEG-UCNPs as a safe and efficient nanoparticulate contrast agent for potential application in multimodal imaging.

  8. ABAB homoleptic bis(phthalocyaninato)lutetium(III) complex: toward the real octupolar cube and giant quadratic hyperpolarizability.

    PubMed

    Ayhan, Mehmet Menaf; Singh, Anu; Hirel, Catherine; Gürek, Ayşe Gül; Ahsen, Vefa; Jeanneau, Erwann; Ledoux-Rak, Isabelle; Zyss, Joseph; Andraud, Chantal; Bretonnière, Yann

    2012-02-29

    The concept of octupolar molecules has considerably enlarged the engineering of second-order nonlinear optical materials by giving access to 2D and 3D architectures. However, if the archetype of octupolar symmetry is a cube with alternating donor and acceptor groups at the corners, no translation of this ideal structure into a real molecule has been realized to date. This may be achieved by designing a bis(phthalocyaninato)lutetium(III) double-decker complex with a crosswise ABAB phthalocyanine bearing alternating electron-donor and electron-acceptor groups. In this communication, we present the first step toward this goal with the synthesis, crystal structure determination, and measurement of the molecular first-order hyperpolarizability β by harmonic light diffusion, of an original lutetium(III) sandwich complex displaying the required ABAB-type alternation for one face of the cube. This structure is characterized by an intense absorption in the near-IR due to an intervalence transition and exhibits the highest quadratic hyperpolarizability ever reported for an octupolar molecule, √<β(2)(HLS)> = 5750 × 10(-30) esu.

  9. Piano-stool lutetium amido and imido compounds supported by a constrained bis(oxazoline)cyclopentadienyl ligand

    DOE PAGES

    Lampland, Nicole L.; Zhu, Jing; Hovey, Megan; ...

    2015-06-25

    {BoMCptet}Lu(CH2Ph)2 (1; BoMCptet = MeC(OxMe2 2C5Me4; OxMe2 = 4,4-dimethyl-2-oxazoline) was prepared in 95% yield from the reaction of BoMCptetH and Lu(CH2Ph)3THF3. Compound 1 reacts with 1 or 2 equiv of H2NCH2R (R = C6H5, 1-C10H7) to give the corresponding imido complexes [{BoMCptet}LuNCH2R]2 (R = C6H5 (2a), 1-C10H7 (2b)) or amido complexes {BoMCptet}Lu(NHCH2R)2 (R = C6H5 (3a), 1-C10H7 (3b)). When isolated, the imido species are insoluble in nonprotic organic solvents. Crystallographic characterization reveals dimeric [{BoMCptet}LuNCH2(1-C10H7)]2 in the solid state. The reaction of 1 and NH3B(C6F5)3 affords crystallographically characterized {BoMCptet}Lu{NHB(C6F5)2}C6F5. This species is proposed to form via a transient lutetium imido, whichmore » undergoes C6F5 migration to the lutetium center.« less

  10. Bis(tetrabenzotriazaporphyrinato) and (tetrabenzotriazaporphyrinato)(phthalocyaninato) lutetium(III) complexes--novel sandwich-type tetrapyrrolic ligand based NIR absorbing electrochromes.

    PubMed

    Pushkarev, Victor E; Kalashnikov, Valery V; Trashin, Stanislav A; Borisova, Nataliya E; Tomilova, Larisa G; Zefirov, Nikolay S

    2013-09-14

    The first sandwich-type complexes have been prepared for tetrabenzotriazaporphyrin ligands. The compounds reveal intrinsic UV-Vis/NIR absorption as well as peculiar electrochromic behavior. The heteroleptic (tetrabenzotriazaporphyrinato)(phthalocyaninato) lutetium derivative shows intermediate spectral and electrochemical properties with respect to homoleptic relatives.

  11. Lutetium oxyorthosilicate block detector readout by avalanche photodiode arrays for high resolution animal PET.

    PubMed

    Pichler, B J; Swann, B K; Rochelle, J; Nutt, R E; Cherry, S R; Siegel, S B

    2004-09-21

    Avalanche photodiodes (APDs) have proven to be useful as light detectors for high resolution positron emission tomography (PET). Their compactness makes these devices excellent candidates for replacing bulky photomultiplier tubes (PMTs) in PET systems where space limitations are an issue. The readout of densely packed, 10 x 10 lutetium oxyorthosilicate (LSO) block detectors (crystal size 2.0 x 2.0 x 12 mm3) with custom-built monolithic 3 x 3 APD arrays was investigated. The APDs had a 5 x 5 mm2 active surface and were arranged on a 6.25 mm pitch. The dead space on the edges of the array was 1.25 mm. The APDs were operated at a bias voltage of approximately 380 V for a gain of 100 and a dark current of 10 nA per APD. The standard deviation in gain between the APDs in the array ranged from 1.8 to 6.5% as the gain was varied from 50 to 108. A fast, low-noise, multi-channel charge sensitive preamplifier application-specific integrated circuit (ASIC) was developed for the APD readout. The amplifier had a rise time of 8 ns, a noise floor of 515 e- rms and a 9 e- pF(-1) noise slope. An acquired flood image showed that all 100 crystals from the block detector could be resolved. Timing measurements with single-channel LSO-APD detectors, as well as with the array, against a plastic scintillator and PMT assembly showed a time resolution of 1.2 ns and 2.5 ns, respectively. The energy resolution measured with a single 4.0 x 4.0 x 10 mm3 LSO crystal, wrapped in four-layer polytetrafluoroethylene (PTFE) tape and coupled with optical grease on a single APD of the array, yielded 15% (full width at half maximum, FWHM) at 511 keV. Stability tests over 9 months of operation showed that the APD arrays do not degrade appreciably. These results demonstrate the ability to decode densely packed LSO scintillation blocks with compact APD arrays. The good timing and energy resolution makes these detectors suitable for high resolution PET.

  12. Influence of cations on the complexation yield of DOTATATE with yttrium and lutetium: a perspective study for enhancing the 90Y and 177Lu labeling conditions.

    PubMed

    Asti, Mattia; Tegoni, Matteo; Farioli, Daniela; Iori, Michele; Guidotti, Claudio; Cutler, Cathy S; Mayer, Pat; Versari, Annibale; Salvo, Diana

    2012-05-01

    The DOTA macrocyclic ligand can form stable complexes with many cations besides yttrium and lutetium. For this reason, the presence of competing cationic metals in yttrium-90 and lutetium-177 chloride solutions can dramatically influence the radiolabeling yield. The aim of this study was to evaluate the coordination yield of yttrium- and lutetium-DOTATATE complexes when the reaction is performed in the presence of varying amounts of competing cationic impurities. In the first set of experiments, the preparation of the samples was performed by using natural yttrium and lutetium (20.4 nmol). The molar ratio between DOTATATE and these metals was 1 to 1. Metal competitors (Pb(2+), Zn(2+), Cu(2+), Fe(3+), Al(3+), Ni(2+), Co(2+), Cr(3+)) were added separately to obtain samples with varying molar ratio with respect to yttrium or lutetium (0.1, 0.5, 1, 2 and 10). The final solutions were analyzed through ultra high-performance liquid chromatography with an UV detector. In the second set of experiments, an amount of (90)Y or (177)Lu chloride (6 MBq corresponding to 3.3 and 45 pmol, respectively) was added to the samples, and a radio-thin layer chromatography analysis was carried out. The coordination of Y(3+) and Lu(3+) was dramatically influenced by low levels of Zn(2+), Cu(2+) and Co(2+). Pb(2+) and Ni(2+) were also shown to be strong competitors at higher concentrations. Fe(3+) was expected to be a strong competitor, but the effect on the incorporation was only partly dependent on its concentration. Al(3+) and Cr(3+) did not compete with Y(3+) and Lu(3+) in the formation of DOTATATE complexes.

  13. 37 CFR 2.176 - Consideration of above matters.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... matters. 2.176 Section 2.176 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE... Consideration of above matters. The matters in §§ 2.171 to 2.175 will be considered in the first instance by the... examiner within six months of the date of issuance, the matter will be considered abandoned. Term...

  14. 37 CFR 2.176 - Consideration of above matters.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... matters. 2.176 Section 2.176 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE... Consideration of above matters. The matters in §§ 2.171 to 2.175 will be considered in the first instance by the... examiner within six months of the date of issuance, the matter will be considered abandoned. Term...

  15. 37 CFR 2.176 - Consideration of above matters.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... matters. 2.176 Section 2.176 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE... Consideration of above matters. The matters in §§ 2.171 to 2.175 will be considered in the first instance by the... examiner within six months of the date of issuance, the matter will be considered abandoned. Term...

  16. 37 CFR 2.176 - Consideration of above matters.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... matters. 2.176 Section 2.176 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE... Consideration of above matters. The matters in §§ 2.171 to 2.175 will be considered in the first instance by the... examiner within six months of the date of issuance, the matter will be considered abandoned. Term...

  17. 2 CFR 176.10 - Purpose of this part.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Purpose of this part. 176.10 Section 176.10 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS Reserved AWARD TERMS FOR...

  18. 2 CFR 176.120 - Determinations on late requests.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Determinations on late requests. 176.120 Section 176.120 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS NATIONAL...

  19. 2 CFR 176.120 - Determinations on late requests.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Determinations on late requests. 176.120 Section 176.120 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS NATIONAL...

  20. 2 CFR 176.20 - Agency responsibilities (general).

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Agency responsibilities (general). 176.20 Section 176.20 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements... enforcement or termination action in accordance with 2 CFR 215.62 or the agency's implementation of the...

  1. 2 CFR 176.10 - Purpose of this part.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Purpose of this part. 176.10 Section 176.10 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS NATIONAL POLICY REQUIREMENTS...

  2. 2 CFR 176.20 - Agency responsibilities (general).

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Agency responsibilities (general). 176.20 Section 176.20 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements... enforcement or termination action in accordance with 2 CFR 215.62 or the agency's implementation of the...

  3. 2 CFR 176.10 - Purpose of this part.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Purpose of this part. 176.10 Section 176.10 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS NATIONAL POLICY REQUIREMENTS...

  4. 2 CFR 176.20 - Agency responsibilities (general).

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Agency responsibilities (general). 176.20 Section 176.20 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements... enforcement or termination action in accordance with 2 CFR 215.62 or the agency's implementation of the...

  5. 2 CFR 176.120 - Determinations on late requests.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Determinations on late requests. 176.120 Section 176.120 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS Reserved AWARD...

  6. 21 CFR 145.176 - Artificially sweetened canned pears.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 2 2011-04-01 2011-04-01 false Artificially sweetened canned pears. 145.176 Section 145.176 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION CANNED FRUITS Requirements for Specific Standardized Canned...

  7. 21 CFR 145.176 - Artificially sweetened canned pears.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Artificially sweetened canned pears. 145.176 Section 145.176 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION CANNED FRUITS Requirements for Specific Standardized Canned...

  8. 42 CFR 415.176 - Renal dialysis services.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Renal dialysis services. 415.176 Section 415.176 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES... Renal dialysis services. In the case of renal dialysis services, physicians who are not paid under...

  9. 49 CFR 176.92 - Cylinders laden in vehicles.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Requirements for Transport Vehicles Loaded With Hazardous Materials and Transported on Board Ferry Vessels § 176.92 Cylinders laden in vehicles. Any cylinder of Class 2 (compressed gas) material which is... 49 Transportation 2 2014-10-01 2014-10-01 false Cylinders laden in vehicles. 176.92 Section...

  10. 49 CFR 176.92 - Cylinders laden in vehicles.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Requirements for Transport Vehicles Loaded With Hazardous Materials and Transported on Board Ferry Vessels § 176.92 Cylinders laden in vehicles. Any cylinder of Class 2 (compressed gas) material which is... 49 Transportation 2 2012-10-01 2012-10-01 false Cylinders laden in vehicles. 176.92 Section...

  11. 49 CFR 176.92 - Cylinders laden in vehicles.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Requirements for Transport Vehicles Loaded With Hazardous Materials and Transported on Board Ferry Vessels § 176.92 Cylinders laden in vehicles. Any cylinder of Class 2 (compressed gas) material which is... 49 Transportation 2 2011-10-01 2011-10-01 false Cylinders laden in vehicles. 176.92 Section...

  12. 49 CFR 176.92 - Cylinders laden in vehicles.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Requirements for Transport Vehicles Loaded With Hazardous Materials and Transported on Board Ferry Vessels § 176.92 Cylinders laden in vehicles. Any cylinder of Class 2 (compressed gas) material which is... 49 Transportation 2 2013-10-01 2013-10-01 false Cylinders laden in vehicles. 176.92 Section...

  13. 49 CFR 176.92 - Cylinders laden in vehicles.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Requirements for Transport Vehicles Loaded With Hazardous Materials and Transported on Board Ferry Vessels § 176.92 Cylinders laden in vehicles. Any cylinder of Class 2 (compressed gas) material which is... 49 Transportation 2 2010-10-01 2010-10-01 false Cylinders laden in vehicles. 176.92 Section...

  14. 2 CFR 176.20 - Agency responsibilities (general).

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Agency responsibilities (general). 176.20 Section 176.20 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements... with 2 CFR 215.62 or the agency's implementation of the OMB Circular A-102 grants management...

  15. 2 CFR 176.120 - Determinations on late requests.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Determinations on late requests. 176.120 Section 176.120 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS AWARD TERMS...

  16. 2 CFR 176.10 - Purpose of this part.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Purpose of this part. 176.10 Section 176.10 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS AWARD TERMS FOR ASSISTANCE...

  17. 2 CFR 176.20 - Agency responsibilities (general).

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Agency responsibilities (general). 176.20 Section 176.20 Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS... appropriate enforcement or termination action in accordance with 2 CFR 215.62 or the agency's...

  18. 2 CFR 176.10 - Purpose of this part.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Purpose of this part. 176.10 Section 176.10 Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS Reserved AWARD TERMS FOR ASSISTANCE AGREEMENTS THAT INCLUDE FUNDS UNDER THE AMERICAN RECOVERY...

  19. 2 CFR 176.120 - Determinations on late requests.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Determinations on late requests. 176.120 Section 176.120 Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS Reserved AWARD TERMS FOR ASSISTANCE AGREEMENTS THAT INCLUDE FUNDS UNDER THE...

  20. 49 CFR 176.39 - Inspection of cargo.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... thereafter, weather permitting, in order to ensure that the cargo is in a safe condition and that no damage... weather. The carrier, its agents, and any person designated for this purpose by the carrier or agents... explosion-proof type. [Amdt. 176-1, 41 FR 16110, Apr. 15, 1976, as amended by Amdt. 176-8, 44 FR 23228,...

  1. 27 CFR 22.176 - Disposition of excess spirits.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2014-04-01 2014-04-01 false Disposition of excess spirits. 22.176 Section 22.176 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY ALCOHOL DISTRIBUTION AND USE OF TAX-FREE ALCOHOL Use of...

  2. 27 CFR 22.176 - Disposition of excess spirits.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Disposition of excess spirits. 22.176 Section 22.176 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS DISTRIBUTION AND USE OF TAX-FREE ALCOHOL Use of...

  3. 27 CFR 22.176 - Disposition of excess spirits.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2012-04-01 2012-04-01 false Disposition of excess spirits. 22.176 Section 22.176 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS DISTRIBUTION AND USE OF TAX-FREE ALCOHOL Use of...

  4. 40 CFR 60.176 - Test methods and procedures.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 7 2014-07-01 2014-07-01 false Test methods and procedures. 60.176 Section 60.176 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) STANDARDS OF PERFORMANCE FOR NEW STATIONARY SOURCES Standards of Performance for Primary...

  5. 40 CFR 60.176 - Test methods and procedures.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 7 2013-07-01 2013-07-01 false Test methods and procedures. 60.176 Section 60.176 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) STANDARDS OF PERFORMANCE FOR NEW STATIONARY SOURCES Standards of Performance for Primary...

  6. 40 CFR 60.176 - Test methods and procedures.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 6 2010-07-01 2010-07-01 false Test methods and procedures. 60.176 Section 60.176 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) STANDARDS OF PERFORMANCE FOR NEW STATIONARY SOURCES Standards of Performance for Primary...

  7. 40 CFR 176.9 - Publication of a tolerance.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Publication of a tolerance. 176.9... TIME-LIMITED TOLERANCES FOR EMERGENCY EXEMPTIONS § 176.9 Publication of a tolerance. (a) If EPA issues... tolerance for residues resulting from use of the pesticide under the exemption will be safe, then EPA...

  8. 40 CFR 176.11 - Duration of a tolerance.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Duration of a tolerance. 176.11... TIME-LIMITED TOLERANCES FOR EMERGENCY EXEMPTIONS § 176.11 Duration of a tolerance. (a) Tolerances... specified by the Administrator. (b) Unless extended, tolerances will automatically expire and be...

  9. 13 CFR 120.176 - Compliance with other laws.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Compliance with other laws. 120.176 Section 120.176 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Policies Applying to All Business Loans Requirements Imposed Under Other Laws and Orders §...

  10. 21 CFR 169.176 - Concentrated vanilla extract.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Concentrated vanilla extract. 169.176 Section 169... Dressings and Flavorings § 169.176 Concentrated vanilla extract. (a) Concentrated vanilla extract conforms... ingredients prescribed for vanilla extract by § 169.175, except that it is concentrated to remove part of...

  11. 21 CFR 169.176 - Concentrated vanilla extract.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 2 2011-04-01 2011-04-01 false Concentrated vanilla extract. 169.176 Section 169... Dressings and Flavorings § 169.176 Concentrated vanilla extract. (a) Concentrated vanilla extract conforms... ingredients prescribed for vanilla extract by § 169.175, except that it is concentrated to remove part of...

  12. ORIGIN OF EXCESS {sup 176}Hf IN METEORITES

    SciTech Connect

    Thrane, Kristine; Connelly, James N.; Bizzarro, Martin; Meyer, Bradley S.; The, Lih-Sin

    2010-07-10

    After considerable controversy regarding the {sup 176}Lu decay constant ({lambda}{sup 176}Lu), there is now widespread agreement that (1.867 {+-} 0.008) x 10{sup -11} yr{sup -1} as confirmed by various terrestrial objects and a 4557 Myr meteorite is correct. This leaves the {sup 176}Hf excesses that are correlated with Lu/Hf elemental ratios in meteorites older than {approx}4.56 Ga meteorites unresolved. We attribute {sup 176}Hf excess in older meteorites to an accelerated decay of {sup 176}Lu caused by excitation of the long-lived {sup 176}Lu ground state to a short-lived {sup 176m}Lu isomer. The energy needed to cause this transition is ascribed to a post-crystallization spray of cosmic rays accelerated by nearby supernova(e) that occurred after 4564.5 Ma. The majority of these cosmic rays are estimated to penetrate accreted material down to 10-20 m, whereas a small fraction penetrate as deep as 100-200 m, predicting decreased excesses of {sup 176}Hf with depth of burial at the time of the irradiation event.

  13. 46 CFR 199.176 - Markings on lifesaving appliances.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Markings on lifesaving appliances. 199.176 Section 199.176 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) LIFESAVING APPLIANCES AND... on lifesaving appliances. (a) Lifeboats and rescue boats. Each lifeboat and rescue boat must...

  14. 46 CFR 199.176 - Markings on lifesaving appliances.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Markings on lifesaving appliances. 199.176 Section 199.176 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) LIFESAVING APPLIANCES AND... on lifesaving appliances. (a) Lifeboats and rescue boats. Each lifeboat and rescue boat must...

  15. 46 CFR 199.176 - Markings on lifesaving appliances.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Markings on lifesaving appliances. 199.176 Section 199.176 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) LIFESAVING APPLIANCES AND... on lifesaving appliances. (a) Lifeboats and rescue boats. Each lifeboat and rescue boat must...

  16. 46 CFR 199.176 - Markings on lifesaving appliances.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Markings on lifesaving appliances. 199.176 Section 199.176 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) LIFESAVING APPLIANCES AND... on lifesaving appliances. (a) Lifeboats and rescue boats. Each lifeboat and rescue boat must...

  17. 46 CFR 199.176 - Markings on lifesaving appliances.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Markings on lifesaving appliances. 199.176 Section 199.176 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) LIFESAVING APPLIANCES AND... on lifesaving appliances. (a) Lifeboats and rescue boats. Each lifeboat and rescue boat must...

  18. 49 CFR 176.160 - Protection against weather.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 2 2011-10-01 2011-10-01 false Protection against weather. 176.160 Section 176.160 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS... Protection against weather. Any person loading or unloading packages containing Class 1 (explosive)...

  19. 49 CFR 176.160 - Protection against weather.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 2 2014-10-01 2014-10-01 false Protection against weather. 176.160 Section 176.160 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS... Protection against weather. Any person loading or unloading packages containing Class 1 (explosive)...

  20. 49 CFR 176.160 - Protection against weather.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Protection against weather. 176.160 Section 176.160 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS... Protection against weather. Any person loading or unloading packages containing Class 1 (explosive)...

  1. 49 CFR 176.160 - Protection against weather.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 2 2012-10-01 2012-10-01 false Protection against weather. 176.160 Section 176.160 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS... Protection against weather. Any person loading or unloading packages containing Class 1 (explosive)...

  2. 49 CFR 176.160 - Protection against weather.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 2 2013-10-01 2013-10-01 false Protection against weather. 176.160 Section 176.160 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS... Protection against weather. Any person loading or unloading packages containing Class 1 (explosive)...

  3. 49 CFR 176.340 - Combustible liquids in portable tanks.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Combustible liquids in portable tanks. 176.340... VESSEL Detailed Requirements for Class 3 (Flammable) and Combustible Liquid Materials § 176.340 Combustible liquids in portable tanks. Combustible liquids, having a flash point of 38 °C (100 °F) or...

  4. 49 CFR 176.340 - Combustible liquids in portable tanks.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 2 2013-10-01 2013-10-01 false Combustible liquids in portable tanks. 176.340... VESSEL Detailed Requirements for Class 3 (Flammable) and Combustible Liquid Materials § 176.340 Combustible liquids in portable tanks. Combustible liquids, having a flash point of 38 °C (100 °F) or...

  5. 49 CFR 176.340 - Combustible liquids in portable tanks.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 2 2014-10-01 2014-10-01 false Combustible liquids in portable tanks. 176.340... VESSEL Detailed Requirements for Class 3 (Flammable) and Combustible Liquid Materials § 176.340 Combustible liquids in portable tanks. Combustible liquids, having a flash point of 38 °C (100 °F) or...

  6. 49 CFR 176.340 - Combustible liquids in portable tanks.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 2 2012-10-01 2012-10-01 false Combustible liquids in portable tanks. 176.340... VESSEL Detailed Requirements for Class 3 (Flammable) and Combustible Liquid Materials § 176.340 Combustible liquids in portable tanks. Combustible liquids, having a flash point of 38 °C (100 °F) or...

  7. 49 CFR 176.340 - Combustible liquids in portable tanks.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 2 2011-10-01 2011-10-01 false Combustible liquids in portable tanks. 176.340... VESSEL Detailed Requirements for Class 3 (Flammable) and Combustible Liquid Materials § 176.340 Combustible liquids in portable tanks. Combustible liquids, having a flash point of 38 °C (100 °F) or...

  8. 49 CFR 176.70 - Stowage requirements for marine pollutants.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 2 2013-10-01 2013-10-01 false Stowage requirements for marine pollutants. 176.70... VESSEL General Handling and Stowage § 176.70 Stowage requirements for marine pollutants. (a) Marine pollutants must be properly stowed and secured to minimize the hazards to the marine environment...

  9. 49 CFR 176.70 - Stowage requirements for marine pollutants.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Stowage requirements for marine pollutants. 176.70... VESSEL General Handling and Stowage § 176.70 Stowage requirements for marine pollutants. (a) Marine pollutants must be properly stowed and secured to minimize the hazards to the marine environment...

  10. 49 CFR 176.70 - Stowage requirements for marine pollutants.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 2 2011-10-01 2011-10-01 false Stowage requirements for marine pollutants. 176.70... VESSEL General Handling and Stowage § 176.70 Stowage requirements for marine pollutants. (a) Marine pollutants must be properly stowed and secured to minimize the hazards to the marine environment...

  11. 49 CFR 176.70 - Stowage requirements for marine pollutants.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 2 2014-10-01 2014-10-01 false Stowage requirements for marine pollutants. 176.70... VESSEL General Handling and Stowage § 176.70 Stowage requirements for marine pollutants. (a) Marine pollutants must be properly stowed and secured to minimize the hazards to the marine environment...

  12. 49 CFR 176.70 - Stowage requirements for marine pollutants.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 2 2012-10-01 2012-10-01 false Stowage requirements for marine pollutants. 176.70... VESSEL General Handling and Stowage § 176.70 Stowage requirements for marine pollutants. (a) Marine pollutants must be properly stowed and secured to minimize the hazards to the marine environment...

  13. 40 CFR 176.9 - Publication of a tolerance.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 25 2013-07-01 2013-07-01 false Publication of a tolerance. 176.9... TIME-LIMITED TOLERANCES FOR EMERGENCY EXEMPTIONS § 176.9 Publication of a tolerance. (a) If EPA issues... tolerance under this part may be established without prior publication of a proposed tolerance or...

  14. 7 CFR 1260.176 - Adjustment of accounts.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Adjustment of accounts. 1260.176 Section 1260.176 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE BEEF PROMOTION AND RESEARCH...

  15. 37 CFR 2.176 - Consideration of above matters.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... matters. 2.176 Section 2.176 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE... Consideration of above matters. The matters in §§ 2.171 to 2.175 will be considered in the first instance by the... examiner within six months of the date of issuance, the matter will be considered abandoned. Term...

  16. 21 CFR 176.110 - Acrylamide-acrylic acid resins.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 3 2013-04-01 2013-04-01 false Acrylamide-acrylic acid resins. 176.110 Section... Substances for Use Only as Components of Paper and Paperboard § 176.110 Acrylamide-acrylic acid resins. Acrylamide-acrylic acid resins may be safely used as components of articles intended for use in...

  17. 21 CFR 161.176 - Frozen raw lightly breaded shrimp.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 2 2011-04-01 2011-04-01 false Frozen raw lightly breaded shrimp. 161.176 Section... Shellfish § 161.176 Frozen raw lightly breaded shrimp. Frozen raw lightly breaded shrimp complies with the provisions of § 161.175, except that it contains not less than 65 percent of shrimp material, as...

  18. 21 CFR 161.176 - Frozen raw lightly breaded shrimp.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 2 2012-04-01 2012-04-01 false Frozen raw lightly breaded shrimp. 161.176 Section... Shellfish § 161.176 Frozen raw lightly breaded shrimp. Frozen raw lightly breaded shrimp complies with the provisions of § 161.175, except that it contains not less than 65 percent of shrimp material, as...

  19. 21 CFR 161.176 - Frozen raw lightly breaded shrimp.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 2 2013-04-01 2013-04-01 false Frozen raw lightly breaded shrimp. 161.176 Section... Shellfish § 161.176 Frozen raw lightly breaded shrimp. Frozen raw lightly breaded shrimp complies with the provisions of § 161.175, except that it contains not less than 65 percent of shrimp material, as...

  20. 21 CFR 161.176 - Frozen raw lightly breaded shrimp.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 2 2014-04-01 2014-04-01 false Frozen raw lightly breaded shrimp. 161.176 Section... Shellfish § 161.176 Frozen raw lightly breaded shrimp. Frozen raw lightly breaded shrimp complies with the provisions of § 161.175, except that it contains not less than 65 percent of shrimp material, as...

  1. 40 CFR 417.176 - Pretreatment standards for new sources.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 29 2011-07-01 2009-07-01 true Pretreatment standards for new sources. 417.176 Section 417.176 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS SOAP AND DETERGENT MANUFACTURING POINT SOURCE CATEGORY Manufacture of Detergents...

  2. 40 CFR 417.176 - Pretreatment standards for new sources.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 30 2013-07-01 2012-07-01 true Pretreatment standards for new sources. 417.176 Section 417.176 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS SOAP AND DETERGENT MANUFACTURING POINT SOURCE CATEGORY Manufacture of Detergents...

  3. 40 CFR 417.176 - Pretreatment standards for new sources.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 28 2010-07-01 2010-07-01 true Pretreatment standards for new sources. 417.176 Section 417.176 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS SOAP AND DETERGENT MANUFACTURING POINT SOURCE CATEGORY Manufacture of Detergents...

  4. 40 CFR 417.176 - Pretreatment standards for new sources.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 30 2012-07-01 2012-07-01 false Pretreatment standards for new sources. 417.176 Section 417.176 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS SOAP AND DETERGENT MANUFACTURING POINT SOURCE CATEGORY Manufacture of Detergents...

  5. 40 CFR 417.176 - Pretreatment standards for new sources.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 29 2014-07-01 2012-07-01 true Pretreatment standards for new sources. 417.176 Section 417.176 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS SOAP AND DETERGENT MANUFACTURING POINT SOURCE CATEGORY Manufacture of Detergents...

  6. 32 CFR 176.45 - Disposal of buildings and property.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... HOMELESS ASSISTANCE § 176.45 Disposal of buildings and property. (a) Puglic benefit transfer screening. Not... document prepared under § 176.45(b). Disposal of buildings and property to be used as homeless assistance facilities shall be to either the LRA or directly to the representative(s) of the homeless and shall...

  7. 32 CFR 176.45 - Disposal of buildings and property.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... HOMELESS ASSISTANCE § 176.45 Disposal of buildings and property. (a) Puglic benefit transfer screening. Not... document prepared under § 176.45(b). Disposal of buildings and property to be used as homeless assistance facilities shall be to either the LRA or directly to the representative(s) of the homeless and shall...

  8. 32 CFR 176.45 - Disposal of buildings and property.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... HOMELESS ASSISTANCE § 176.45 Disposal of buildings and property. (a) Puglic benefit transfer screening. Not... document prepared under § 176.45(b). Disposal of buildings and property to be used as homeless assistance facilities shall be to either the LRA or directly to the representative(s) of the homeless and shall...

  9. 32 CFR 176.45 - Disposal of buildings and property.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... HOMELESS ASSISTANCE § 176.45 Disposal of buildings and property. (a) Puglic benefit transfer screening. Not... document prepared under § 176.45(b). Disposal of buildings and property to be used as homeless assistance facilities shall be to either the LRA or directly to the representative(s) of the homeless and shall...

  10. 49 CFR 176.210 - On deck stowage requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false On deck stowage requirements. 176.210 Section 176.210 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS REGULATIONS CARRIAGE BY VESSEL Detailed Requirements for Class 2 (Compressed...

  11. 46 CFR 154.176 - Longitudinal contiguous hull structure.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Longitudinal contiguous hull structure. 154.176 Section... Equipment Hull Structure § 154.176 Longitudinal contiguous hull structure. (a) The longitudinal contiguous hull structure of a vessel having cargo containment systems without secondary barriers must meet...

  12. 19 CFR 122.176 - Removal from ACSPP.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Removal from ACSPP. 122.176 Section 122.176 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE... proper order of a Customs officer or any Customs order, rule, or regulation relative to its...

  13. 50 CFR 622.176 - Recordkeeping and reporting.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Recordkeeping and reporting. 622.176 Section 622.176 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND... this section. (2) Electronic logbook/video monitoring reporting. The owner or operator of a vessel...

  14. 50 CFR 622.176 - Recordkeeping and reporting.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 12 2014-10-01 2014-10-01 false Recordkeeping and reporting. 622.176 Section 622.176 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND... this section. (2) Electronic logbook/video monitoring reporting. The owner or operator of a vessel...

  15. 40 CFR 60.176 - Test methods and procedures.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 7 2012-07-01 2012-07-01 false Test methods and procedures. 60.176... Smelters § 60.176 Test methods and procedures. (a) In conducting the performance tests required in § 60.8, the owner or operator shall use as reference methods and procedures the test methods in appendix A...

  16. 40 CFR 60.176 - Test methods and procedures.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 6 2011-07-01 2011-07-01 false Test methods and procedures. 60.176... Smelters § 60.176 Test methods and procedures. (a) In conducting the performance tests required in § 60.8, the owner or operator shall use as reference methods and procedures the test methods in appendix A...

  17. 21 CFR 145.176 - Artificially sweetened canned pears.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 2 2014-04-01 2014-04-01 false Artificially sweetened canned pears. 145.176... § 145.176 Artificially sweetened canned pears. (a) Artificially sweetened canned pears is the food which conforms to the definition and standard of identity prescribed for canned pears by § 145.175(a) except...

  18. 21 CFR 145.176 - Artificially sweetened canned pears.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 2 2013-04-01 2013-04-01 false Artificially sweetened canned pears. 145.176... § 145.176 Artificially sweetened canned pears. (a) Artificially sweetened canned pears is the food which conforms to the definition and standard of identity prescribed for canned pears by § 145.175(a) except...

  19. 21 CFR 145.176 - Artificially sweetened canned pears.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 2 2012-04-01 2012-04-01 false Artificially sweetened canned pears. 145.176... § 145.176 Artificially sweetened canned pears. (a) Artificially sweetened canned pears is the food which conforms to the definition and standard of identity prescribed for canned pears by § 145.175(a) except...

  20. 20 CFR 220.176 - When disability continues or ends.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 1 2014-04-01 2012-04-01 true When disability continues or ends. 220.176... ACT DETERMINING DISABILITY Continuing or Stopping Disability Due to Substantial Gainful Activity or Medical Improvement § 220.176 When disability continues or ends. There is a statutory requirement that,...

  1. 20 CFR 220.176 - When disability continues or ends.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 1 2011-04-01 2011-04-01 false When disability continues or ends. 220.176... ACT DETERMINING DISABILITY Continuing or Stopping Disability Due to Substantial Gainful Activity or Medical Improvement § 220.176 When disability continues or ends. There is a statutory requirement that,...

  2. 20 CFR 220.176 - When disability continues or ends.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 1 2013-04-01 2012-04-01 true When disability continues or ends. 220.176... ACT DETERMINING DISABILITY Continuing or Stopping Disability Due to Substantial Gainful Activity or Medical Improvement § 220.176 When disability continues or ends. There is a statutory requirement that,...

  3. 20 CFR 220.176 - When disability continues or ends.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 1 2012-04-01 2012-04-01 false When disability continues or ends. 220.176... ACT DETERMINING DISABILITY Continuing or Stopping Disability Due to Substantial Gainful Activity or Medical Improvement § 220.176 When disability continues or ends. There is a statutory requirement that,...

  4. 21 CFR 176.110 - Acrylamide-acrylic acid resins.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 3 2012-04-01 2012-04-01 false Acrylamide-acrylic acid resins. 176.110 Section... Substances for Use Only as Components of Paper and Paperboard § 176.110 Acrylamide-acrylic acid resins. Acrylamide-acrylic acid resins may be safely used as components of articles intended for use in...

  5. 21 CFR 176.110 - Acrylamide-acrylic acid resins.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 3 2014-04-01 2014-04-01 false Acrylamide-acrylic acid resins. 176.110 Section... Paper and Paperboard § 176.110 Acrylamide-acrylic acid resins. Acrylamide-acrylic acid resins may be...) Acrylamide-acrylic acid resins are produced by the polymerization of acrylamide with partial hydrolysis or...

  6. 21 CFR 176.110 - Acrylamide-acrylic acid resins.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 3 2011-04-01 2011-04-01 false Acrylamide-acrylic acid resins. 176.110 Section... Substances for Use Only as Components of Paper and Paperboard § 176.110 Acrylamide-acrylic acid resins. Acrylamide-acrylic acid resins may be safely used as components of articles intended for use in...

  7. Raman scattering in organic semiconductors based on erbium biphthalocyanine molecules and chlorine-containing europium-lutetium triphthalocyanine molecules

    SciTech Connect

    Belogorokhov, I. A.; Mamichev, D. A.; Dronov, M. A.; Pushkarev, V. E.; Tomilova, L. G.; Khokhlov, D. R.

    2010-08-15

    The Raman spectra of semiconductor structures based on erbium biphthalocyanine molecules and chlorine-substituted europium-lutetium triphthalocyanine molecules are studied on excitation with Ar{sup +} laser radiation at the wavelength 514 nm. The data on the spectral position of Raman intensity peaks related to vibronic states of the basic molecular groups forming the semiconductor are obtained. Raman lines irrelevant to the known vibronic states of the basic phthalocyanine molecular groups are observed in the ranges 100-500 and 500-900 cm{sup -1}. It is shown that, in the spectra of triphthalocyanine, some lines are structurally complex and shifted with respect to the characteristic lines of molecular groups by several inverse centimeters.

  8. In situ chemichromic studies of interactions between a lutetium bis-octaalkyl-substituted phthalocyanine and selected biological cofactors.

    PubMed

    Pal, C; Cammidge, A N; Cook, M J; Sosa-Sanchez, J L; Sharma, A K; Ray, A K

    2012-01-07

    Spin-coated films, approximately 100 nm thick, of a newly synthesized bis[octakis(octyl)phthalocyaninato] lutetium(III) complex on ultrasonically cleaned glass substrates exhibit pronounced chemichromic behaviour with potential application in healthcare. In situ kinetic optical absorption spectroscopic measurements show that the phthalocyanine Q-band is red shifted by 60 nm upon oxidation arising from exposure to bromine vapour. Recovery to the original state is achieved by the treatment of the oxidized films with nicotinamide adenine dinucleotide and l-ascorbic acid (vitamin C) in an aqueous solution containing 1.5 M lithium perchlorate. The neutralization process is found to be governed by first-order kinetics. The linear increase of the reduction rate with increasing concentration of cofactors provides a basis for calibration of analyte concentrations ranging from 3.5 mM down to 0.03 mM.

  9. Nonlinear optical properties of lutetium and dysprosium bisphthalocyanines at 1550 nm with femto- and nanosecond pulse excitation

    NASA Astrophysics Data System (ADS)

    Plekhanov, A. I.; Basova, T. V.; Parkhomenko, R. G.; Gürek, A. G.

    2017-02-01

    In this work, the nonlinear optical properties of unsubstituted lutetium (LuPc2) and dysprosium (DyPc2) bisphthalocyanines as well as octasubstituted Lu(PcR8)2 derivative with R=-S(C6H13) were studied at a wavelength of 1550 nm with 10 ns and 300 fs pulses. Based on Z-scan measurements the nonlinear absorption and refraction coefficient as well as the nature of nonlinear optical properties were analyzed for these materials. Open aperture Z-scan indicates strong two-photon absorption in all three bisphthalocyanines in nano- and femtosecond regimes. With good nonlinear optical coefficients, bisphthalocyanines of rare earth elements are expected to be promising materials for the creation of optical limiters.

  10. In situ chemichromic studies of interactions between a lutetium bis-octaalkyl-substituted phthalocyanine and selected biological cofactors

    PubMed Central

    Pal, C.; Cammidge, A. N.; Cook, M. J.; Sosa-Sanchez, J. L.; Sharma, A. K.; Ray, A. K.

    2012-01-01

    Spin-coated films, approximately 100 nm thick, of a newly synthesized bis[octakis(octyl)phthalocyaninato] lutetium(III) complex on ultrasonically cleaned glass substrates exhibit pronounced chemichromic behaviour with potential application in healthcare. In situ kinetic optical absorption spectroscopic measurements show that the phthalocyanine Q-band is red shifted by 60 nm upon oxidation arising from exposure to bromine vapour. Recovery to the original state is achieved by the treatment of the oxidized films with nicotinamide adenine dinucleotide and l-ascorbic acid (vitamin C) in an aqueous solution containing 1.5 M lithium perchlorate. The neutralization process is found to be governed by first-order kinetics. The linear increase of the reduction rate with increasing concentration of cofactors provides a basis for calibration of analyte concentrations ranging from 3.5 mM down to 0.03 mM. PMID:21676969

  11. Low-damping sub-10-nm thin films of lutetium iron garnet grown by molecular-beam epitaxy

    NASA Astrophysics Data System (ADS)

    Jermain, C. L.; Paik, H.; Aradhya, S. V.; Buhrman, R. A.; Schlom, D. G.; Ralph, D. C.

    2016-11-01

    We analyze the structural and magnetic characteristics of (111)-oriented lutetium iron garnet (Lu3Fe5O12) films grown by molecular-beam epitaxy, for films as thin as 2.8 nm. Thickness-dependent measurements of the in- and out-of-plane ferromagnetic resonance allow us to quantify the effects of two-magnon scattering, along with the surface anisotropy and the saturation magnetization. We achieve effective damping coefficients of 11.1 (9 )×10-4 for 5.3 nm films and 32 (3 )×10-4 for 2.8 nm films, among the lowest values reported to date for any insulating ferrimagnetic sample of comparable thickness.

  12. Updated results of a phase I trial of motexafin lutetium-mediated interstitial photodynamic therapy in patients with locally recurrent prostate cancer.

    PubMed

    Verigos, Kosmas; Stripp, Diana C Hsiung; Mick, Rosemarie; Zhu, Timothy C; Whittington, Richard; Smith, Debbie; Dimofte, Andreea; Finlay, Jarod; Busch, Theresa M; Tochner, Zelig A; Malkowicz, S; Glatstein, Eli; Hahn, Stephen M

    2006-01-01

    Locally recurrent prostate cancer after treatment with radiation therapy is a clinical problem with few acceptable treatments. One potential treatment, photodynamic therapy (PDT), is a modality that uses laser light, drug photosensitizer, and oxygen to kill tumor cells through direct cellular cytotoxicity and/or through destruction of tumor vasculature. A Phase I trial of interstitial PDT with the photosensitizer Motexafin lutetium was initiated in men with locally recurrent prostate cancer. In this ongoing trial, the primary objective is to determine the maximally tolerated dose of Motexafin lutetium-mediated PDT. Other objectives include evaluation of Motexafin lutetium uptake from prostate tissue using a spectrofluorometric assay and evaluation of optical properties in the human prostate. Fifteen men with biopsy-proven locally recurrent prostate cancer and no evidence of distant metastatic disease have been enrolled and 14 have been treated. Treatment plans were developed using transrectal ultrasound images. The PDT dose was escalated by increasing the Motexafin lutetium dose, increasing the 732 ran light dose, and decreasing the drug-light interval. Motexafin lutetium doses ranged from 0.5 to 2 mg/kg administered IV 24, 6, or 3 hr prior to 732 ran light delivery. The light dose, measured in real time with in situ spherical detectors was 25-100 J/cm2. Light was delivered via optical fibers inserted through a transperineal brachytherapy template in the operating room. Optical property measurements were made before and after light therapy. Prostate biopsies were obtained before and after light delivery for spectrofluorometric measurements of photosensitizer uptake. Fourteen patients have completed protocol treatment on eight dose levels without dose-limiting toxicity. Grade I genitourinary symptoms that are PDT related have been observed. One patient had Grade II urinary urgency that was urinary catheter related. No rectal or other gastrointestinal PDT-related tox

  13. 49 CFR 176.60 - “No Smoking” signs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... and Stowage § 176.60 “No Smoking” signs. When smoking is prohibited during the loading, stowing... the vessel are jointly responsible for posting “NO SMOKING” signs in conspicuous locations....

  14. 49 CFR 176.60 - “No Smoking” signs.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... and Stowage § 176.60 “No Smoking” signs. When smoking is prohibited during the loading, stowing... the vessel are jointly responsible for posting “NO SMOKING” signs in conspicuous locations....

  15. 49 CFR 176.60 - “No Smoking” signs.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... and Stowage § 176.60 “No Smoking” signs. When smoking is prohibited during the loading, stowing... the vessel are jointly responsible for posting “NO SMOKING” signs in conspicuous locations....

  16. 49 CFR 176.60 - “No Smoking” signs.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... and Stowage § 176.60 “No Smoking” signs. When smoking is prohibited during the loading, stowing... the vessel are jointly responsible for posting “NO SMOKING” signs in conspicuous locations....

  17. 49 CFR 176.60 - “No Smoking” signs.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... and Stowage § 176.60 “No Smoking” signs. When smoking is prohibited during the loading, stowing... the vessel are jointly responsible for posting “NO SMOKING” signs in conspicuous locations....

  18. COURTYARD CREATED BY FACILITIES 176, 177, AND 178, OBLIQUE VIEW ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    COURTYARD CREATED BY FACILITIES 176, 177, AND 178, OBLIQUE VIEW FACING SE. - U.S. Naval Base, Pearl Harbor, Housing Area 1, Bounded by Kamehameha Highway, Plantation Drive, South Avenue, Pearl City, Honolulu County, HI

  19. Facility No. 176, oblique view of north and east sides, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Facility No. 176, oblique view of north and east sides, corner of Facility No. 175 is to the right - U.S. Naval Base, Pearl Harbor, Landplane Hangar Type, Wasp Boulevard and Gambier Bay Street, Pearl City, Honolulu County, HI

  20. 50 CFR 218.176 - Letters of Authorization.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Complex and the Associated Proposed Extensions Study Area § 218.176 Letters of Authorization. (a) A Letter... determination that the total number of marine mammals taken by the activity as a whole will have no more than...

  1. 176. Photographic copy of original construction drawing dated February 10, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    176. Photographic copy of original construction drawing dated February 10, 1933 (from Record Group 115, Denver Branch of the National Archives, Denver). OWYHEE DAM; LOCATION OF THERMOMETER GROUPS. - Owyhee Dam, Across Owyhee River, Nyssa, Malheur County, OR

  2. 50 CFR 217.176 - Applications for Letters of Authorization.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Maintenance of the Neptune Liquefied Natural Gas Facility Off Massachusetts § 217.176 Applications for Letters.... Citizen (as defined by § 216.103) conducting the activity identified in § 217.170(a) (i.e., Neptune)...

  3. 50 CFR 217.176 - Applications for Letters of Authorization.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Maintenance of the Neptune Liquefied Natural Gas Facility Off Massachusetts § 217.176 Applications for Letters.... Citizen (as defined by § 216.103) conducting the activity identified in § 217.170(a) (i.e., Neptune)...

  4. 50 CFR 217.176 - Applications for Letters of Authorization.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Maintenance of the Neptune Liquefied Natural Gas Facility Off Massachusetts § 217.176 Applications for Letters.... Citizen (as defined by § 216.103) conducting the activity identified in § 217.170(a) (i.e., Neptune)...

  5. 50 CFR 217.176 - Applications for Letters of Authorization.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Maintenance of the Neptune Liquefied Natural Gas Facility Off Massachusetts § 217.176 Applications for Letters.... Citizen (as defined by § 216.103) conducting the activity identified in § 217.170(a) (i.e., Neptune)...

  6. Detection of genetically modified corn (Bt176) in spiked cow blood samples by polymerase chain reaction and immunoassay methods.

    PubMed

    Petit, Laetitia; Baraige, Fabienne; Bertheau, Yves; Brunschwig, Philippe; Diolez, Annick; Duhem, Koenraad; Duplan, Marie-Noëlle; Fach, Patrick; Kobilinsky, André; Lamart, Stephen; Schattner, Alexandra; Martin, Patrice

    2005-01-01

    The fate of DNA and protein transgenic sequences in products derived from animals fed transgenic crops has recently raised public interest. Sensitive molecular tests targeting the Bt176 genetic construct and the transgenic Cry1Ab protein were developed to determine whether plant sequences, especially transgenic sequences, are present in animal products. A protocol for total DNA extraction and purification from cow whole blood samples was first drawn up and assessed by spiking with known amounts of DNA from Bt176 maize. The limit of detection for transgenic sequences (35S promoter and Bt176-specific junction sequence) was determined by both the polymerase chain reaction-enzyme-linked immunosorbent assay (PCR-ELISA) and the 5'-nuclease PCR assay. Four additional PCR systems were built to substantiate the results. The first detects a mono-copy maize-specific sequence (ADH promoter). Two others target multi-copy sequences from plant nucleus (26S rRNA gene) and chloroplast (psaB gene). The last one, used as a positive control, targets a mono-copy animal sequence (alpha(s1)-casein gene). Both methods detected a minimum spiking at 25 copies of Bt176 maize/mL in 10 mL whole blood samples. The sandwich ELISA kit used detected down to 1 ng transgenic Cry1Ab protein/mL spiked whole blood.

  7. Piano-stool lutetium amido and imido compounds supported by a constrained bis(oxazoline)cyclopentadienyl ligand

    SciTech Connect

    Lampland, Nicole L.; Zhu, Jing; Hovey, Megan; Jana, Barun; Ellern, Arkady; Sadow, Aaron D.

    2015-06-25

    {BoMCptet}Lu(CH2Ph)2 (1; BoMCptet = MeC(OxMe2 2C5Me4; OxMe2 = 4,4-dimethyl-2-oxazoline) was prepared in 95% yield from the reaction of BoMCptetH and Lu(CH2Ph)3THF3. Compound 1 reacts with 1 or 2 equiv of H2NCH2R (R = C6H5, 1-C10H7) to give the corresponding imido complexes [{BoMCptet}LuNCH2R]2 (R = C6H5 (2a), 1-C10H7 (2b)) or amido complexes {BoMCptet}Lu(NHCH2R)2 (R = C6H5 (3a), 1-C10H7 (3b)). When isolated, the imido species are insoluble in nonprotic organic solvents. Crystallographic characterization reveals dimeric [{BoMCptet}LuNCH2(1-C10H7)]2 in the solid state. The reaction of 1 and NH3B(C6F5)3 affords crystallographically characterized {BoMCptet}Lu{NHB(C6F5)2}C6F5. This species is proposed to form via a transient lutetium imido, which undergoes C6F5 migration to the lutetium center.

  8. A novel glucose sensor using lutetium phthalocyanine as redox mediator in reduced graphene oxide conducting polymer multifunctional hydrogel.

    PubMed

    Al-Sagur, H; Komathi, S; Khan, M A; Gurek, A G; Hassan, A

    2017-06-15

    Herein, we report a scalable synthesis of multifunctional conducting polyacrylic acid (PAA) hydrogel (MFH) integrated with reduced grapheme oxide (rGO), vinyl substituted polyaniline (VS-PANI) and lutetium Phthalocyanine (LuPc2) as three dimensional robust matrix for glucose oxidase (GOx) immobilization (PAA-rGO/VS-PANI/LuPc2/GOx-MFH). We have integrated the multicomponents such as PAA with rGO, and VS-PANI through free radical polymerization using methylene bis-acrylamide, and ammonium persulphate as the cross linker and initiator. The LuPc2 was then doped to form multifunctional hydrogel (PAA-rGO/VS-PANI/LuPc2-MFH). Finally, biosensor was fabricated by immobilizing GOx into PAA-rGO/VS-PANI/LuPc2-MFH and subsequently used for electrochemical detection of glucose. The PAA-rGO/VS-PANI/LuPc2/GOx-MFH biosensor exhibited high sensitivity (15.31μAmM(-1)cm(-2)) for the detection of glucose over a concentration range of 2-12mM with a low detection limit of 25µm. The PAA-rGO/VS-PANI/LuPc2-MFH biosensor showed a fast response time (1s) to the addition of glucose with high storage stability of 3 months. The real sample analysis reveals that PAA-rGO/VS-PANI/LuPc2/GOx-MFH could be effectively used as an electrochemical biosensor in industrial as well clinical diagnosis.

  9. Spectroscopic refractive indices of monoclinic single crystal and ceramic Lutetium oxyorthosilicate (LSO) from 200 to 850 nm

    SciTech Connect

    Jellison Jr, Gerald Earle; Specht, Eliot D; Boatner, Lynn A; Singh, David J; Melcher, Charles L

    2012-01-01

    The four real values of the dielectric function tensor of the monoclinic crystal Lu2SiO5 or lutetium oxyorthosilicate (LSO) have been determined using generalized ellipsometry from 200 to 850 nm. The three principal values are fit to the Sellmeier model, and they indicate that the band gap of LSO is less than ~9 eV. The off-diagonal element 12 is non-zero over the entire spectrum, but it is very close to zero for wavelengths longer than ~400 nm, indicating that structurally monoclinic LSO is nearly optically orthorhombic in this wavelength region. The spectroscopic dielectric functions of three isotropic ceramic LSO samples are presented, which are consistent with the dielectric functions of single-crystal LSO when the effects of porosity are included. As a comparison, the dielectric functions are also determined using relativistic electronic structure and optical calculations based on the recently developed potential functional of Tran and Blaha (Phys. Rev. Lett. 102, 226401 (2009).)

  10. Photodynamic inactivation of pathogenic species Pseudomonas aeruginosa and Candida albicans with lutetium (III) acetate phthalocyanines and specific light irradiation.

    PubMed

    Mantareva, Vanya; Kussovski, Vesselin; Durmuş, Mahmut; Borisova, Ekaterina; Angelov, Ivan

    2016-11-01

    Photodynamic inactivation (PDI) is a light-associated therapeutic approach suitable for treatment of local acute infections. The method is based on specific light-activated compound which by specific irradiation and in the presence of molecular oxygen produced molecular singlet oxygen and other reactive oxygen species, all toxic for pathogenic microbial cells. The study presents photodynamic impact of two recently synthesized water-soluble cationic lutetium (III) acetate phthalocyanines (LuPc-5 and LuPc-6) towards two pathogenic strains, namely, the Gram-negative bacterium Pseudomonas aeruginosa and a fungus Candida albicans. The photodynamic effect was evaluated for the cells in suspensions and organized in 48-h developed biofilms. The relatively high levels of uptakes of LuPc-5 and LuPc-6 were determined for fungal cells compared to bacterial cells. The penetration depths and distribution of both LuPcs into microbial biofilms were investigated by means of confocal fluorescence microscopy. The photoinactivation efficiency was studied for a wide concentration range (0.85-30 μM) of LuPc-5 and LuPc-6 at a light dose of 50 J cm(-2) from red light-emitting diode (LED; 665 nm). The PDI study on microbial biofilms showed incomplete photoinactivation (<3 logs) for the used gentle drug-light protocol.

  11. 21 CFR 176.130 - Anti-offset substances.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... FOR HUMAN CONSUMPTION (CONTINUED) INDIRECT FOOD ADDITIVES: PAPER AND PAPERBOARD COMPONENTS Substances for Use Only as Components of Paper and Paperboard § 176.130 Anti-offset substances. Substances named in paragraphs (b) and (c) of this section may be safely used to prevent the transfer of inks...

  12. 21 CFR 176.130 - Anti-offset substances.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... FOR HUMAN CONSUMPTION (CONTINUED) INDIRECT FOOD ADDITIVES: PAPER AND PAPERBOARD COMPONENTS Substances for Use Only as Components of Paper and Paperboard § 176.130 Anti-offset substances. Substances named in paragraphs (b) and (c) of this section may be safely used to prevent the transfer of inks...

  13. 49 CFR 176.89 - Control of transport vehicles.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Special Requirements for Transport Vehicles Loaded With Hazardous Materials and Transported on Board Ferry Vessels § 176.89 Control of transport vehicles. (a) A transport vehicle containing hazardous materials may...; (8) No hazardous materials are to be released from the vehicle; and (9) Any instructions given by...

  14. 49 CFR 176.89 - Control of transport vehicles.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Special Requirements for Transport Vehicles Loaded With Hazardous Materials and Transported on Board Ferry Vessels § 176.89 Control of transport vehicles. (a) A transport vehicle containing hazardous materials may...; (8) No hazardous materials are to be released from the vehicle; and (9) Any instructions given by...

  15. 49 CFR 176.89 - Control of transport vehicles.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Special Requirements for Transport Vehicles Loaded With Hazardous Materials and Transported on Board Ferry Vessels § 176.89 Control of transport vehicles. (a) A transport vehicle containing hazardous materials may...; (8) No hazardous materials are to be released from the vehicle; and (9) Any instructions given by...

  16. 49 CFR 176.89 - Control of transport vehicles.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Special Requirements for Transport Vehicles Loaded With Hazardous Materials and Transported on Board Ferry Vessels § 176.89 Control of transport vehicles. (a) A transport vehicle containing hazardous materials may...; (8) No hazardous materials are to be released from the vehicle; and (9) Any instructions given by...

  17. 49 CFR 176.89 - Control of transport vehicles.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Special Requirements for Transport Vehicles Loaded With Hazardous Materials and Transported on Board Ferry Vessels § 176.89 Control of transport vehicles. (a) A transport vehicle containing hazardous materials may...; (8) No hazardous materials are to be released from the vehicle; and (9) Any instructions given by...

  18. 49 CFR 176.700 - General stowage requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Detailed Requirements for Radioactive Materials § 176.700 General stowage requirements. (a) (b) A package of radioactive materials which in still air has a surface temperature more than 5 °C (9 °F) above the... compartment in which it is stowed must be ventilated. (c) For a shipment of radioactive materials...

  19. COURTYARD CREATED BY FACILITIES 176, 177, AND 178 (LEFT TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    COURTYARD CREATED BY FACILITIES 176, 177, AND 178 (LEFT TO RIGHT), WITH TWO-STORY DUPLEXES FLANKING A FOURPLEX (FACILITY 177), FRONT ELEVATION FROM FACILITY 256 ACROSS MAIN STREET, VIEW FACING NE. - U.S. Naval Base, Pearl Harbor, Housing Area 1, Bounded by Kamehameha Highway, Plantation Drive, South Avenue, Pearl City, Honolulu County, HI

  20. Airfield setting of Facility Nos. 175 and 176, taken from ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Airfield setting of Facility Nos. 175 and 176, taken from north end of Ford Island Runway, with landplane hangars on the right - U.S. Naval Base, Pearl Harbor, Landplane Hangar Type, Wasp Boulevard and Gambier Bay Street, Pearl City, Honolulu County, HI

  1. 32 CFR 176.45 - Disposal of buildings and property.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... described at § 176.20(b). (b) Environmental analysis. Prior to disposal of any real property, the Military... 1990, as amended (10 U.S.C. 2687 note), complete an environmental impact analysis of all reasonable... impact analysis process to ensure both that the LRA is provided the most current...

  2. 46 CFR 154.176 - Longitudinal contiguous hull structure.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 154.176 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS... hull structure of a vessel having cargo containment systems without secondary barriers must meet the... secondary barriers must be designed for a temperature that is: (1) Colder than the calculated temperature...

  3. 46 CFR 154.176 - Longitudinal contiguous hull structure.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 154.176 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS... hull structure of a vessel having cargo containment systems without secondary barriers must meet the... secondary barriers must be designed for a temperature that is: (1) Colder than the calculated temperature...

  4. 46 CFR 154.176 - Longitudinal contiguous hull structure.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 154.176 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS... hull structure of a vessel having cargo containment systems without secondary barriers must meet the... secondary barriers must be designed for a temperature that is: (1) Colder than the calculated temperature...

  5. 49 CFR 176.142 - Hazardous materials of extreme flammability.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Hazardous materials of extreme flammability. 176... of extreme flammability. (a) Except as allowed by paragraph (b) of this section, certain hazardous materials of extreme flammability may not be transported in a vessel carrying Class 1 (explosive)...

  6. 46 CFR 160.176-4 - Incorporation by reference.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Director of the Federal Register in accordance with 5 U.S.C. 552(a). To enforce any edition other than the..., West Conshohocken, PA 19428-2959. ASTM B 117-97, Standard Practice for Operating Salt Spray (Fog... 975-98, Standard Specification for Diesel Fuel Oils—160.176-13 ASTM D 1434-82 (1988), Standard...

  7. 14 CFR 93.176 - Description of area.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ..., AZ § 93.176 Description of area. The Luke Air Force Base, Arizona Terminal Area is designated during... base of the overlaying Phoenix Class B airspace bounded by a line beginning at: Lat. 33°23′56″ N; Long...) South section lower includes airspace extending from 2,100 feet MSL to the base of the...

  8. 14 CFR 93.176 - Description of area.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ..., AZ § 93.176 Description of area. The Luke Air Force Base, Arizona Terminal Area is designated during... base of the overlaying Phoenix Class B airspace bounded by a line beginning at: Lat. 33°23′56″ N; Long...) South section lower includes airspace extending from 2,100 feet MSL to the base of the...

  9. 14 CFR 93.176 - Description of area.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ..., AZ § 93.176 Description of area. The Luke Air Force Base, Arizona Terminal Area is designated during... base of the overlaying Phoenix Class B airspace bounded by a line beginning at: Lat. 33°23′56″ N; Long...) South section lower includes airspace extending from 2,100 feet MSL to the base of the...

  10. 42 CFR 415.176 - Renal dialysis services.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... TEACHING SETTINGS, AND RESIDENTS IN CERTAIN SETTINGS Physician Services in Teaching Settings § 415.176... physician monthly capitation payment method (as described in § 414.314 of this chapter) must meet the requirements of §§ 415.170 and 415.172 (concerning physician fee schedule payment for services of...

  11. 37 CFR 1.176 - Examination of reissue.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Section 1.176 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE, DEPARTMENT OF...) Restriction between subject matter of the original patent claims and previously unclaimed subject matter may be required (restriction involving only subject matter of the original patent claims will not...

  12. 49 CFR 176.700 - General stowage requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Detailed Requirements for Radioactive Materials § 176.700 General stowage requirements. (a) (b) A package of radioactive materials which in still air has a surface temperature more than 5 °C (9 °F) above the... compartment in which it is stowed must be ventilated. (c) For a shipment of radioactive materials...

  13. 49 CFR 176.315 - Fire protection requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... CFR 95.50), dry chemical (45.4 kg (100 pounds) minimum capacity) or equivalent fire extinguisher, or a... hand portable dry chemical or two portable 10 L (2.6 gallons) foam-type extinguishers must be... CFR part 98 or 46 CFR part 64. [Amdt. 176-30, 55 FR 52705, Dec. 21, 1990, as amended at 56 FR...

  14. 32 CFR 176.35 - HUD's review of the application.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... HOMELESS ASSISTANCE § 176.35 HUD's review of the application. (a) Timing. HUD shall complete a review of... to the expressed interest and requests of representatives of the homeless, whether the application: (1) Need. Takes into consideration the size and nature of the homeless population in the...

  15. 32 CFR 176.35 - HUD's review of the application.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... HOMELESS ASSISTANCE § 176.35 HUD's review of the application. (a) Timing. HUD shall complete a review of... to the expressed interest and requests of representatives of the homeless, whether the application: (1) Need. Takes into consideration the size and nature of the homeless population in the...

  16. 32 CFR 176.35 - HUD's review of the application.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... HOMELESS ASSISTANCE § 176.35 HUD's review of the application. (a) Timing. HUD shall complete a review of... to the expressed interest and requests of representatives of the homeless, whether the application: (1) Need. Takes into consideration the size and nature of the homeless population in the...

  17. 32 CFR 176.35 - HUD's review of the application.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... HOMELESS ASSISTANCE § 176.35 HUD's review of the application. (a) Timing. HUD shall complete a review of... to the expressed interest and requests of representatives of the homeless, whether the application: (1) Need. Takes into consideration the size and nature of the homeless population in the...

  18. 49 CFR 176.133 - Magazine stowage Type C.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... requirements for magazine stowage type C are the same as for a closed cargo transport unit in § 176.63(e). In... be closer to the vessel's side than a distance equal to one-eighth of the vessel's beam or 2.4 m...

  19. 10 CFR 431.176 - Voluntary Independent Certification Programs.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Section 431.176 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY EFFICIENCY PROGRAM FOR CERTAIN... meets these standards. (9) The program has a standard for determining whether the efficiency rating a... if the verification testing results show it is not in compliance with EPCA efficiency standards,...

  20. 9 CFR 381.176 - Place of maintenance of records.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... AGRICULTURE AGENCY ORGANIZATION AND TERMINOLOGY; MANDATORY MEAT AND POULTRY PRODUCTS INSPECTION AND VOLUNTARY....176 Place of maintenance of records. Every person engaged in any business described in § 381.175(a) shall maintain the records required by § 381.175 at the place of business where such business...

  1. 21 CFR 176.350 - Tamarind seed kernel powder.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...) FOOD FOR HUMAN CONSUMPTION (CONTINUED) INDIRECT FOOD ADDITIVES: PAPER AND PAPERBOARD COMPONENTS Substances for Use Only as Components of Paper and Paperboard § 176.350 Tamarind seed kernel powder. Tamarind..., manufacturing, packing, processing, preparing, treating, packaging, transporting, or holding food, subject...

  2. Lutetium-177-labeled gastrin releasing peptide receptor binding analogs: a novel approach to radionuclide therapy.

    PubMed

    Panigone, S; Nunn, A D

    2006-12-01

    Optimization of therapy for individual patients remains a goal of clinical practice. Radionuclide imaging can identify those patients who may benefit from subsequent targeted therapy by providing regional information on the distribution of the target. An ideal situation may be when the imaging and the therapeutic compounds are the same agent. Two antibodies ([ [90Y]ibritumomab, [131I]tositumomab) are now approved for the systemic radiotherapy of non-Hodgkin's lymphoma. The main hurdle is to deliver higher absorbed doses to the more refractory solid tumors paying particular regard to the bone marrow toxicity. The low dose is thought to be a result of the large size of antibodies slowing delivery to the target. Peptides having high affinity to receptors expressed on cancer cells are a promising alternative. They are usually rapidly excreted from the body through renal and/or hepatobiliary excretion thus creating a prolonged accumulation of the radioactivity in the kidneys, which represents a recognized issue for systemic radiotherapy. The first radiopeptide developed was a somatostatin analogue, which led to a major breakthrough in the field. Beside the kidney issue, somatostatin use remains limited to few cancers that express receptors in sufficiently large quantities, mainly neuroendocrine tumors. The gastrin releasing peptide (GRP) receptor is an attractive target for development of new radiopeptides with diagnostic and therapeutic potential. This is based upon the functional expression of GRP receptors in several of the more prevalent cancers including prostate, breast, and small cell lung cancer. This review covers the efforts currently underway to develop new and clinically promising GRP-receptor specific molecules labeled with imageable and therapeutic radionuclides.

  3. Bioelectronic tongue based on lipidic nanostructured layers containing phenol oxidases and lutetium bisphthalocyanine for the analysis of grapes.

    PubMed

    Medina-Plaza, C; de Saja, J A; Rodriguez-Mendez, M L

    2014-07-15

    In this work, a multisensor system formed by nanostructured voltammetric biosensors based on phenol oxidases (tyrosinase and laccase) has been developed. The enzymes have been incorporated into a biomimetic environment provided by a Langmuir-Blodgett (LB) film of arachidic acid (AA). Lutetium bisphthalocyanine (LuPc2) has also been introduced in the films to act as electron mediator. The incorporation of the enzymes to the floating layers to form Tyr/AA/LuPc2 and Lac/AA/LuPc2 films has been confirmed by the expansion in the surface pressure isotherms and by the AFM images. The voltammetric response towards six phenolic compounds demonstrates the enhanced performance of the biosensors that resulted from a preserved activity of the tyrosinase and laccase combined with the electron transfer activity of LuPc2. Biosensors show improved detection limits in the range of 10(-7)-10(-8) mol L(-1). An array formed by three sensors AA/LuPc2, Tyr/AA/LuPc2 and Lac/AA/LuPc2 has been employed to discriminate phenolic antioxidants of interest in the food industry. The Principal Component Analysis scores plot has demonstrated that the multisensor system is able to discriminate phenols according to the number of phenolic groups attached to the structure. The system has also been able to discriminate grapes of different varieties according to their phenolic content. This good performance is due to the combination of four factors: the high functionality of the enzyme obtained using a biomimetic immobilization, the signal enhancement caused by the LuPc2 mediator, the improvement in the selectivity induced by the enzymes and the complementary activity of the enzymatic sensors demonstrated in the loading plots.

  4. Feasibility of repeated sequential treatments of RIF-1 tumors with photodynamic therapy (PDT) using lutetium texaphyrin (PCI-0123)

    NASA Astrophysics Data System (ADS)

    Miles, Dale R.; Parker, Lynn M.; Thiemann, Patricia A.; Woodburn, Kathryn W.; Young, Stuart W.

    1997-05-01

    Lutetium texaphyrin (PCI-0123) is currently in clinical trials as a PDT agent for the treatment of cancer patients. The drug is cleared rapidly from the plasma, and photoirradiation can be performed shortly after drug administration.T He photosensitizer as yet does not appear to elicit any significant skin photosensitivity. These characteristics favor frequent multiple PDT treatments with PCI-0123. In order to support repeated PDT treatments in the clinic, the safety of multiple drug dosing was studied in rats and mice. In rats, each group received 5 consecutive daily intravenous administrations of 5, 15, 30, or 60 mg/kg/day of PCI-0123. There were no deaths in any of the groups, and no drug-related effects were detected in the 5 mg/kg/day group. In mice, there were no observable signs of toxicity after consecutive daily administration of 10 micrometers ol/kg/day of PCI-0123 for 13 days. The feasibility and efficacy of repeated PDT treatments were assessed in C3H mice bearing RIF-1 tumors. Repeated PDT proved to be superior to a single PDT treatment. Repeated PDT treatments were well tolerated. Seven PDT treatments were administered over a nine day period without significant toxicity while achieving good therapeutic responses. All six groups receiving repeated PDT treatments showed an improved response compared to groups receiving a single PDT cycle, and the improvement was statistically significant for five of these groups. Sixty-two percent of mice receiving four sequential daily treatments were cured, and daily treatments were superior to regimens with longer intervals between PDT cycles.

  5. In vivo reflectance measurement of optical properties, blood oxygenation and motexafin lutetium uptake in canine large bowels, kidneys and prostates.

    PubMed

    Solonenko, Michael; Cheung, Rex; Busch, Theresa M; Kachur, Alex; Griffin, Gregory M; Vulcan, Theodore; Zhu, Timothy C; Wang, Hsing-Wen; Hahn, Stephen M; Yodh, A G

    2002-03-21

    Motexafin lutetium (MLu) is a second-generation photosensitizer for photodynamic therapy (PDT) of cancer. We have developed and applied a diffuse optical reflectance spectrometer for in vivo measurement of MLu uptake, optical properties, haemoglobin concentration and haemoglobin oxygen saturation in normal canine large bowels, kidneys and prostates. The probe consists of a broadband fibre-optic-coupled light source and detector fibres placed at various distances from the source fibre to collect reflected light. An analysis based on the diffusion approximation of the photon transport equation was used to recover tissue optical properties from the reflectance measurements. The instrumentation and analysis methods were validated using measurements from homogeneous, highly scattering phantoms with known MLu concentrations. The same techniques were then used to estimate chromophore concentrations of normal canine large bowels, kidneys and prostates. We estimated (mean (standard deviation)) total haemoglobin concentrations of 119 (25), 340 (92) and 51 (11) microM in the large bowels, kidneys and prostates of four dogs, respectively; tissue blood oxygen saturations in these same organs were 75 (15), 76 (21) and 74 (16) per cent, respectively. Tissue MLu concentrations (mg l(-1)) were estimated from data taken 3.5 h after injection of a 2 mg kg(-1) injected dose; data from three dogs gave concentrations of 2.4 (0.4) in large bowels, 6.8 (1.3) in kidneys and 2.2 (1.1) in prostates. The reduced scattering coefficients, mu's, estimated for large bowels, kidneys and prostates at 730 nm were, respectively: 10.1 (1.3), 19.6 (4.0) and 12.7 (0.6) cm(-1). We observed significant variability in MLu uptake, tissue scattering and haemoglobin concentration between organs and even between the same organ in different dogs. This class of in situ optical property measurement may be desirable to individualize PDT drug and light delivery.

  6. ^176Lu/^175Lu thermometry for Oklo natural reactors: a new look at old data

    NASA Astrophysics Data System (ADS)

    Gould, Chris; Sharapov, Eduard

    2012-03-01

    Lutetium thermometry has been used to analyze Oklo natural nuclear reactor zones but leads to widely varying and puzzling predictions for the temperatures TO, which in turn impacts Oklo bounds on the time variation of the fine structure constant α. We revisit results for reactor zone RZ10 in light of new astrophysical measurements of the isomer branching ratio B^g in ^175Lu neutron capture at 5 and 25 keV. We recalculate predictions for TO as a function of B^g using realistic models of the Oklo neutron flux. We find TO= 100 ±30 C using a new value of B^g, in contrast to 350 < TO< 500 C using the evaluated value at thermal energy. Lutetium thermometry can be applicable to analyses of Oklo reactor data, but a better measurement of B^g with thermal neutrons is needed to confirm the reliability of temperature predictions.

  7. 7 CFR 28.176 - Designation of official certificates, memoranda, marks, other identifications, and devices for...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ..., other identifications, and devices for purpose of the Agricultural Marketing Act. 28.176 Section 28.176 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE COMMODITY STANDARDS AND STANDARD...

  8. Radiative neutron capture cross sections on 176Lu at DANCE

    NASA Astrophysics Data System (ADS)

    Roig, O.; Jandel, M.; Méot, V.; Bond, E. M.; Bredeweg, T. A.; Couture, A. J.; Haight, R. C.; Keksis, A. L.; Rundberg, R. S.; Ullmann, J. L.; Vieira, D. J.

    2016-03-01

    The cross section of the neutron capture reaction 176Lu(n ,γ ) has been measured for a wide incident neutron energy range with the Detector for Advanced Neutron Capture Experiments at the Los Alamos Neutron Science Center. The thermal neutron capture cross section was determined to be (1912 ±132 ) b for one of the Lu natural isotopes, 176Lu. The resonance part was measured and compared to the Mughabghab's atlas using the R -matrix code, sammy. At higher neutron energies the measured cross sections are compared to ENDF/B-VII.1, JEFF-3.2, and BRC evaluated nuclear data. The Maxwellian averaged cross sections in a stellar plasma for thermal energies between 5 keV and 100 keV were extracted using these data.

  9. 49 CFR 176.184 - Class 1 (explosive) materials of Compatibility Group L.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Group L. 176.184 Section 176.184 Transportation Other Regulations Relating to Transportation PIPELINE... (explosive) Materials in Port § 176.184 Class 1 (explosive) materials of Compatibility Group L. Class 1 (explosive) materials in compatibility group L may not be handled in a port area without the...

  10. 32 CFR 176.25 - HUD's negotiations and consultations with the LRA.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false HUD's negotiations and consultations with the LRA. 176.25 Section 176.25 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE... REDEVELOPMENT AND HOMELESS ASSISTANCE § 176.25 HUD's negotiations and consultations with the LRA. HUD...

  11. 32 CFR 176.25 - HUD's negotiations and consultations with the LRA.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false HUD's negotiations and consultations with the LRA. 176.25 Section 176.25 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE... REDEVELOPMENT AND HOMELESS ASSISTANCE § 176.25 HUD's negotiations and consultations with the LRA. HUD...

  12. 30 CFR 206.176 - How do I perform accounting for comparison?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false How do I perform accounting for comparison? 206.176 Section 206.176 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT PRODUCT VALUATION Indian Gas § 206.176 How do I perform accounting for comparison?...

  13. 49 CFR 176.907 - Polymeric Beads and Plastic Molding Compounds.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 2 2014-10-01 2014-10-01 false Polymeric Beads and Plastic Molding Compounds. 176.907 Section 176.907 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS..., and Plastic Molding Compounds § 176.907 Polymeric Beads and Plastic Molding Compounds. (a)...

  14. 49 CFR 176.907 - Polymeric Beads and Plastic Molding Compounds.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 2 2013-10-01 2013-10-01 false Polymeric Beads and Plastic Molding Compounds. 176.907 Section 176.907 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS..., and Plastic Molding Compounds § 176.907 Polymeric Beads and Plastic Molding Compounds. (a)...

  15. 49 CFR 176.104 - Loading and unloading Class 1 (explosive) materials.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...) materials. 176.104 Section 176.104 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS REGULATIONS CARRIAGE BY VESSEL Detailed Requirements for Class 1 (Explosive) Materials § 176.104 Loading and...

  16. 49 CFR 176.182 - Conditions for handling on board ship.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 2 2013-10-01 2013-10-01 false Conditions for handling on board ship. 176.182 Section 176.182 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS... Port § 176.182 Conditions for handling on board ship. (a) Weather conditions. Class 1...

  17. 49 CFR 176.182 - Conditions for handling on board ship.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 2 2014-10-01 2014-10-01 false Conditions for handling on board ship. 176.182 Section 176.182 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS... Port § 176.182 Conditions for handling on board ship. (a) Weather conditions. Class 1...

  18. 49 CFR 176.182 - Conditions for handling on board ship.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 2 2011-10-01 2011-10-01 false Conditions for handling on board ship. 176.182 Section 176.182 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS... Port § 176.182 Conditions for handling on board ship. (a) Weather conditions. Class 1...

  19. 49 CFR 176.116 - General stowage conditions for Class 1 (explosive) materials.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...) materials. 176.116 Section 176.116 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS REGULATIONS CARRIAGE BY VESSEL Detailed Requirements for Class 1 (Explosive) Materials Stowage § 176.116...

  20. 30 CFR 1206.176 - How do I perform accounting for comparison?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...? 1206.176 Section 1206.176 Mineral Resources OFFICE OF NATURAL RESOURCES REVENUE, DEPARTMENT OF THE INTERIOR NATURAL RESOURCES REVENUE PRODUCT VALUATION Indian Gas § 1206.176 How do I perform accounting for comparison? (a) This section applies if the gas produced from your Indian lease is processed and that...