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Sample records for lutetium 187

  1. Lutetium ultraphosphate.

    PubMed

    Horchani-Naifer, Karima; Férid, Mokhtar

    2008-05-10

    The structure of the title compound, LuP(5)O(14), comprises puckered eight-membered PO(4) rings linked by the lutetium cations in a complex way, forming a three-dimensional framework. Each eight-membered phosphate ring shares a bridging tetra-hedron with each of four adjacent tetra-hedra, to form layers of PO(4) tetra-hedra. These layers are c/2 in thickness and parallel to the ab plane. Each Lu ion is contained in one such layer, forming bonds to six O atoms in that layer and also to one O atom belonging to a tetra-hedron in each of the layers lying above and below it. The LuO(8) polyhedra are isolated from one another, since they share no common atoms. The Lu ions lie on twofold axes (special position 4e) and the shortest Lu⋯Lu distance is 5.703 (1) Å.

  2. Lutetium ultraphosphate

    PubMed Central

    Horchani-Naifer, Karima; Férid, Mokhtar

    2008-01-01

    The structure of the title compound, LuP5O14, comprises puckered eight-membered PO4 rings linked by the lutetium cations in a complex way, forming a three-dimensional framework. Each eight-membered phosphate ring shares a bridging tetra­hedron with each of four adjacent tetra­hedra, to form layers of PO4 tetra­hedra. These layers are c/2 in thickness and parallel to the ab plane. Each Lu ion is contained in one such layer, forming bonds to six O atoms in that layer and also to one O atom belonging to a tetra­hedron in each of the layers lying above and below it. The LuO8 polyhedra are isolated from one another, since they share no common atoms. The Lu ions lie on twofold axes (special position 4e) and the shortest Lu⋯Lu distance is 5.703 (1) Å. PMID:21202435

  3. Fermi surface measurements of lutetium

    NASA Astrophysics Data System (ADS)

    Johanson, W. R.; Crabtree, G. W.; Schmidt, F. A.

    1982-03-01

    We report de Haas-van Alphen (dHvA) measurements of the Fermi surface of lutetium at temperatures down to 0.3 K and in fields up to 150 kG in the (101¯0) and (112¯0) planes. Lutetium, having a filled 4f shell, serves as a nonmagnetic prototype of the structurally similar (hcp), trivalent, heavy rare earths from Gd to Tm. No complete frequency branches were observed, indicating that there are no closed pieces of surface. We observed all but one orbit predicted by relativistic-augmented-plane wave (RAPW) calculations of Keeton and Loucks, and the data support a geometry that is in good qualitative agreement with the existence of nested open electron and hole sheets.

  4. Fermi surface measurements of lutetium

    SciTech Connect

    Johanson, W.R.; Crabtree, G.W.; Schmidt, F.A.

    1982-03-01

    We report de Haas-van Alphen (dHvA) measurements of the Fermi surface of lutetium at temperatures down to 0.3 K and in fields up to 150 kG in the (1010) and (1120) planes. Lutetium, having a filled 4f shell, serves as a nonmagnetic prototype of the structurally similar (hcp), trivalent, heavy rare earths from Gd to Tm. No complete frequency branches were observed, indicating that there are no closed pieces of surface. We observed all but one orbit predicted by relativistic-augmented-plane wave (RAPW) calculations of Keeton and Loucks, and the data support a geometry that is in good qualitative agreement with the existence of nested open electron and hole sheets.

  5. Fermi surface measurements of lutetium

    SciTech Connect

    Johanson, W.R.; Crabtree, G.W.; Schmidt, F.A.

    1982-01-01

    We report de Haas-van Alphen (dHvA) measurements of the Fermi surface of Lutetium at temperatures down to .3K and in fields up to 150 kG in the (1010) and (1120) planes. Lutetium, having a filled 4f shell, serves as a non-magnetic prototype of the structurally similar (hcp), trivalent, heavy rare-earths from Gd to Tm. No complete frequency branches were observed, indicating that there are no closed pieces of surface. We observed all but one orbit predicted by relativistic-augmented-plane wave (RAPW) calculations of Keeton and Loucks, and the data support a geometry that is in good qualitative agreement with the existence of nested open electron and hole sheets.

  6. Selective photoionisation of lutetium isotopes

    SciTech Connect

    D'yachkov, Aleksei B; Kovalevich, S K; Labozin, Valerii P; Mironov, Sergei M; Panchenko, Vladislav Ya; Firsov, Valerii A; Tsvetkov, G O; Shatalova, G G

    2012-10-31

    A three-stage laser photoionisation scheme intended for enriching the {sup 176}Lu isotope from natural lutetium was considered. An investigation was made of the hyperfine structure of the second excited state 5d6s7s {yields} {sup 4}D{sub 3/2} with an energy of 37194 cm{sup -1} and the autoionisation state with an energy of 53375 cm{sup -1} of the {sup 176}Lu and {sup 175}Lu isotopes. The total electron momentum of the autoionisation level and the constant A of hyperfine magnetic interaction were determined. Due to a small value of the isotopic shift between {sup 176}Lu and {sup 175}Lu, appreciable selectivity of their separation may be achieved with individual hyperfine structure components. The first tentative enrichment of the 176Lu isotope was performed to a concentration of 60 % - 70 %. (laser applications and other topics in quantum electronics)

  7. Unpacking 187: Targeting Mejicanas.

    ERIC Educational Resources Information Center

    Hondagneu-Sotelo, Pierrette

    Passed in November 1994, California's Proposition 187 was intended to deny public school education and health care to undocumented immigrants and their children. The rhetoric of current anti-immigrant hysteria has shifted from that of recent decades and relies on both racist and sexist imagery. This narrative shift, with its emphasis on women and…

  8. Lutetium oxide-based transparent ceramic scintillators

    DOEpatents

    Seeley, Zachary; Cherepy, Nerine; Kuntz, Joshua; Payne, Stephen A.

    2016-01-19

    In one embodiment, a transparent ceramic of sintered nanoparticles includes gadolinium lutetium oxide doped with europium having a chemical composition (Lu.sub.1-xGd.sub.x).sub.2-YEu.sub.YO.sub.3, where X is any value within a range from about 0.05 to about 0.45 and Y is any value within a range from about 0.01 to about 0.2, and where the transparent ceramic exhibits a transparency characterized by a scatter coefficient of less than about 10%/cm. In another embodiment, a transparent ceramic scintillator of sintered nanoparticles, includes a body of sintered nanoparticles including gadolinium lutetium oxide doped with a rare earth activator (RE) having a chemical composition (Lu.sub.1-xGd.sub.x).sub.2-YRE.sub.YO.sub.3, where RE is selected from the group consisting of: Sm, Eu, Tb, and Dy, where the transparent ceramic exhibits a transparency characterized by a scatter coefficient of less than about 10%/cm.

  9. Calibration of the lutetium-hafnium clock.

    PubMed

    Scherer, E; Munker, C; Mezger, K

    2001-07-27

    Well-defined constants of radioactive decay are the cornerstone of geochronology and the use of radiogenic isotopes to constrain the time scales and mechanisms of planetary differentiation. Four new determinations of the lutetium-176 decay constant (lambda176Lu) made by calibration against the uranium-lead decay schemes yield a mean value of 1.865 +/- 0.015 x 10(-11) year(-1), in agreement with the two most recent decay-counting experiments. Lutetium-hafnium ages that are based on the previously used lambda176Lu of 1.93 x 10(-11) to 1.94 x 10(-11) year(-1) are thus approximately 4% too young, and the initial hafnium isotope compositions of some of Earth's oldest minerals and rocks become less radiogenic relative to bulk undifferentiated Earth when calculated using the new decay constant. The existence of strongly unradiogenic hafnium in Early Archean and Hadean zircons implies that enriched crustal reservoirs existed on Earth by 4.3 billion years ago and persisted for 200 million years or more. Hence, current models of early terrestrial differentiation need revision.

  10. Static and Dynamical Properties of heavy actinide Monopnictides of Lutetium.

    PubMed

    Mir, Showkat H; Jha, Prakash C; Islam, M S; Banarjee, Amitava; Luo, Wei; Dabhi, Shweta D; Jha, Prafulla K; Ahuja, R

    2016-07-07

    In this work, density functional theory within the framework of generalized gradient approximation has been used to investigate the structural, elastic, mechanical, and phonon properties of lutetium monopnictides in rock-salt crystal structure. The spin orbit coupling and Hubbard-U corrections are included to correctly predict the essential properties of these compounds. The elastic constants, Young's modulus E, Poisson's ratio v, shear modulus G, anisotropy factor A and Pugh's ratio are computed. We found that all lutetium monopnictides are anisotropic and show brittle character. From the wave velocities along [100], [110] and [111] directions, melting temperature of lutetium monopnictides are predicted. Dynamical stability of these monopnictides has been studied by density functional perturbation theory.

  11. Static and Dynamical Properties of heavy actinide Monopnictides of Lutetium

    PubMed Central

    Mir, Showkat H.; Jha, Prakash C.; Islam, M. S.; Banarjee, Amitava; Luo, Wei; Dabhi, Shweta D.; Jha, Prafulla K.; Ahuja, R.

    2016-01-01

    In this work, density functional theory within the framework of generalized gradient approximation has been used to investigate the structural, elastic, mechanical, and phonon properties of lutetium monopnictides in rock-salt crystal structure. The spin orbit coupling and Hubbard-U corrections are included to correctly predict the essential properties of these compounds. The elastic constants, Young’s modulus E, Poisson’s ratio v, shear modulus G, anisotropy factor A and Pugh’s ratio are computed. We found that all lutetium monopnictides are anisotropic and show brittle character. From the wave velocities along [100], [110] and [111] directions, melting temperature of lutetium monopnictides are predicted. Dynamical stability of these monopnictides has been studied by density functional perturbation theory. PMID:27384709

  12. Hydrothermal synthesis of lutetium disilicate nanoparticles

    SciTech Connect

    Tang Xiaoping; Gao Yanfeng; Chen Hongfei; Luo Hongjie

    2012-04-15

    A simple, low-cost hydrothermal method was developed to synthesize irregular-and rod-shaped lutetium disilicate (Lu{sub 2}Si{sub 2}O{sub 7}) powders with sizes ranging from 71 to 340 nm. The synthesis temperature was 260 Degree-Sign C, which is nearly 1300 Degree-Sign C lower than that required for the solid-state reaction. The results indicated that both the hydrothermal temperature and pH values had great influences on the composition, crystalline phase and morphology of the powders. The formation mechanism, basic thermophysical properties, stability and anticorrosion properties of the Lu{sub 2}Si{sub 2}O{sub 7} powders were also investigated. The obtained powders possessed low thermal conductivity, a suitable thermal expansion coefficient (3.92-5.17 Multiplication-Sign 10{sup -6} K{sup -1}) with the silicon-based substrate and excellent thermal and structural stability. During hot corrosion testing, the surfaces of the samples appeared to react with the water and molten salt vapors, but no serious failure occurred. - Graphical abstract: An image for the as-prepared Lu{sub 2}Si{sub 2}O{sub 7} powders (left) and XRD pattern (right) (inset shows the SEM graph of powders). Highlights: Black-Right-Pointing-Pointer We synthesized Lu{sub 2}Si{sub 2}O{sub 7} powders via a hydrothermal process at 260 Degree-Sign C. Black-Right-Pointing-Pointer Crystalline phase and morphology of the powders changed with experimental parameter. Black-Right-Pointing-Pointer Hot corrosion was determined in an airflow environment containing alkaline vapor.

  13. Discovery of gallium, germanium, lutetium, and hafnium isotopes

    SciTech Connect

    Gross, J.L.; Thoennessen, M.

    2012-09-15

    Currently, twenty-eight gallium, thirty-one germanium, thirty-five lutetium, and thirty-six hafnium isotopes have been observed and the discovery of these isotopes is described here. For each isotope a brief synopsis of the first refereed publication, including the production and identification method, is presented.

  14. Nuclear Data Sheets for A = 187

    SciTech Connect

    Basunia, M.S.

    2009-05-15

    Evaluated spectroscopic data and level schemes from radioactive decay and nuclear reaction studies are presented for {sup 187}Hf, {sup 187}Ta, {sup 187}W, {sup 187}Re, {sup 187}Os, {sup 187}Ir, {sup 187}Pt, {sup 187}Au, {sup 187}Hg, {sup 187}Tl, {sup 187}Pb, {sup 187}Bi, and {sup 187}Po. This evaluation for A = 187 supersedes the earlier one by R.B. Firestone (1991Fi02) published in Nuclear Data Sheets 62, 159 (1991) and the {sup 187}Tl evaluation by C.M. Baglin (1999Ba24) published in Nuclear Data Sheets 86, 487 (1999). Highlights of this publication are the following: This evaluation includes first identifications of {sup 187}Hf, {sup 187}Ta (1999Be63, 2000PoZY) and {sup 187}Po (2006An11) nuclides. A B(E2){up_arrow} = 0.080 12 was determined by 1967Bi10 for the 9/2+ state at 845 keV in {sup 187}Re Coulomb Excitation. Using this B(E2) value and the adopted 845{gamma} ray properties, a T{sub 1/2}=54 fs 34 can be deduced for the 845 keV level of {sup 187}Re. This T{sub 1/2} yields a large B(E2)(W.u.){approx}1.3x105 for the 263{gamma} (depopulating the same level) indicating either substantial unobserved feeding or incorrect g-ray branching intensities of this level. The decay of g.s. and isomer of {sup 187}Tl are poorly known (please see {sup 187}Tl {epsilon} decay (51 s+15.60 s)). Based on {sup 191}Po {alpha} decay studies, 2002An19 establishes a {sup 187}Pb isomeric level energy at 2(15) keV and assigns J{pi}=13/2+ for the {sup 187}Pb g.s. and J{pi}=3/2- for the isomeric state (inverse of the systematics of odd-mass Pb nuclei in this region). From {sup 187}Pb and {sup 187}Pb{sup m} mass measurements, 2005We11 determined the isomeric level energy at 33(13) keV.

  15. Optical Response of Shocked Cerium-Doped Lutetium Oxyorthosilicate

    SciTech Connect

    G. D. Stevens

    2003-03-01

    Shock experiments were performed in order to characterize the triboluminescent signature of cerium-doped lutetium oxyorthosilicate (LSO:Ce). This material shows prompt, nano-second timescale light emission when driven by explosive detonation. When properly applied to a surface, it may be used as a shock arrival sensor, and also for imaging the propagation of a shock front. Triboluminescent rise times, spectral content, and spatial resolution measurements are presented.

  16. 28 CFR 115.187 - Data collection.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Data collection. 115.187 Section 115.187... Standards for Lockups Data Collection and Review § 115.187 Data collection. (a) The agency shall collect accurate, uniform data for every allegation of sexual abuse at lockups under its direct control using...

  17. 28 CFR 115.187 - Data collection.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 2 2014-07-01 2014-07-01 false Data collection. 115.187 Section 115.187... Standards for Lockups Data Collection and Review § 115.187 Data collection. (a) The agency shall collect accurate, uniform data for every allegation of sexual abuse at lockups under its direct control using...

  18. 28 CFR 115.187 - Data collection.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Data collection. 115.187 Section 115.187... Standards for Lockups Data Collection and Review § 115.187 Data collection. (a) The agency shall collect accurate, uniform data for every allegation of sexual abuse at lockups under its direct control using...

  19. 33 CFR 117.187 - Petaluma River.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Petaluma River. 117.187 Section 117.187 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements California § 117.187 Petaluma River. (a) The draws...

  20. 33 CFR 117.187 - Petaluma River.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Petaluma River. 117.187 Section 117.187 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements California § 117.187 Petaluma River. (a) The draws...

  1. 7 CFR 18.7 - Reports.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Reports. 18.7 Section 18.7 Agriculture Office of the Secretary of Agriculture EQUAL EMPLOYMENT OPPORTUNITY IN THE STATE COOPERATIVE EXTENSION SERVICES § 18.7 Reports. Within 6 months of the program going into effect and thereafter at least annually, the...

  2. 7 CFR 18.7 - Reports.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 1 2013-01-01 2013-01-01 false Reports. 18.7 Section 18.7 Agriculture Office of the Secretary of Agriculture EQUAL EMPLOYMENT OPPORTUNITY IN THE STATE COOPERATIVE EXTENSION SERVICES § 18.7 Reports. Within 6 months of the program going into effect and thereafter at least annually, the...

  3. 14 CFR 187.7 - Copies; seal.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Copies; seal. 187.7 Section 187.7... REGULATIONS FEES § 187.7 Copies; seal. The fees for furnishing photostatic or similar copies of documents and for affixation of the seal for a certification or validation are the same as those provided in...

  4. 14 CFR 187.7 - Copies; seal.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Copies; seal. 187.7 Section 187.7... REGULATIONS FEES § 187.7 Copies; seal. The fees for furnishing photostatic or similar copies of documents and for affixation of the seal for a certification or validation are the same as those provided in...

  5. 14 CFR 187.7 - Copies; seal.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Copies; seal. 187.7 Section 187.7... REGULATIONS FEES § 187.7 Copies; seal. The fees for furnishing photostatic or similar copies of documents and for affixation of the seal for a certification or validation are the same as those provided in...

  6. 14 CFR 187.7 - Copies; seal.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Copies; seal. 187.7 Section 187.7... REGULATIONS FEES § 187.7 Copies; seal. The fees for furnishing photostatic or similar copies of documents and for affixation of the seal for a certification or validation are the same as those provided in...

  7. 14 CFR 187.7 - Copies; seal.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Copies; seal. 187.7 Section 187.7... REGULATIONS FEES § 187.7 Copies; seal. The fees for furnishing photostatic or similar copies of documents and for affixation of the seal for a certification or validation are the same as those provided in...

  8. 5 CFR 550.187 - Transitional provisions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Transitional provisions. 550.187 Section 550.187 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PAY ADMINISTRATION (GENERAL) Premium Pay Law Enforcement Availability Pay § 550.187 Transitional provisions....

  9. 5 CFR 550.187 - Transitional provisions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 1 2013-01-01 2013-01-01 false Transitional provisions. 550.187 Section 550.187 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PAY ADMINISTRATION (GENERAL) Premium Pay Law Enforcement Availability Pay § 550.187 Transitional provisions....

  10. 5 CFR 550.187 - Transitional provisions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 1 2012-01-01 2012-01-01 false Transitional provisions. 550.187 Section 550.187 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PAY ADMINISTRATION (GENERAL) Premium Pay Law Enforcement Availability Pay § 550.187 Transitional provisions....

  11. 5 CFR 550.187 - Transitional provisions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Transitional provisions. 550.187 Section 550.187 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PAY ADMINISTRATION (GENERAL) Premium Pay Law Enforcement Availability Pay § 550.187 Transitional provisions....

  12. 5 CFR 550.187 - Transitional provisions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false Transitional provisions. 550.187 Section 550.187 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PAY ADMINISTRATION (GENERAL) Premium Pay Law Enforcement Availability Pay § 550.187 Transitional provisions....

  13. 40 CFR 421.187 - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 29 2014-07-01 2012-07-01 true 421.187 Section 421.187 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS NONFERROUS METALS MANUFACTURING POINT SOURCE CATEGORY Primary and Secondary Germanium and Gallium Subcategory § 421.187...

  14. 40 CFR 421.187 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 28 2010-07-01 2010-07-01 true 421.187 Section 421.187 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS NONFERROUS METALS MANUFACTURING POINT SOURCE CATEGORY Primary and Secondary Germanium and Gallium Subcategory § 421.187...

  15. 40 CFR 421.187 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 29 2011-07-01 2009-07-01 true 421.187 Section 421.187 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS NONFERROUS METALS MANUFACTURING POINT SOURCE CATEGORY Primary and Secondary Germanium and Gallium Subcategory § 421.187...

  16. 40 CFR 421.187 - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 30 2013-07-01 2012-07-01 true 421.187 Section 421.187 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS NONFERROUS METALS MANUFACTURING POINT SOURCE CATEGORY Primary and Secondary Germanium and Gallium Subcategory § 421.187...

  17. 40 CFR 421.187 - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 30 2012-07-01 2012-07-01 false 421.187 Section 421.187 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS NONFERROUS METALS MANUFACTURING POINT SOURCE CATEGORY Primary and Secondary Germanium and Gallium Subcategory § 421.187...

  18. 46 CFR 45.187 - Weather limitations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 2 2012-10-01 2012-10-01 false Weather limitations. 45.187 Section 45.187 Shipping... River Barges on Lake Michigan Routes § 45.187 Weather limitations. (a) Tows on the Burns Harbor route must operate during fair weather conditions only. (b) The weather limits (ice conditions, wave...

  19. 46 CFR 45.187 - Weather limitations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 2 2013-10-01 2013-10-01 false Weather limitations. 45.187 Section 45.187 Shipping... River Barges on Lake Michigan Routes § 45.187 Weather limitations. (a) Tows on the Burns Harbor route must operate during fair weather conditions only. (b) The weather limits (ice conditions, wave...

  20. 46 CFR 45.187 - Weather limitations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 2 2011-10-01 2011-10-01 false Weather limitations. 45.187 Section 45.187 Shipping... River Barges on Lake Michigan Routes § 45.187 Weather limitations. (a) Tows on the Burns Harbor route must operate during fair weather conditions only. (b) The weather limits (ice conditions, wave...

  1. 46 CFR 45.187 - Weather limitations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 2 2010-10-01 2010-10-01 false Weather limitations. 45.187 Section 45.187 Shipping... River Barges on Lake Michigan Routes § 45.187 Weather limitations. (a) Tows on the Burns Harbor route must operate during fair weather conditions only. (b) The weather limits (ice conditions, wave...

  2. 46 CFR 45.187 - Weather limitations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 2 2014-10-01 2014-10-01 false Weather limitations. 45.187 Section 45.187 Shipping... River Barges on Lake Michigan Routes § 45.187 Weather limitations. (a) Tows on the Burns Harbor route must operate during fair weather conditions only. (b) The weather limits (ice conditions, wave...

  3. 32 CFR 187.5 - Responsibilities.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 1 2013-07-01 2013-07-01 false Responsibilities. 187.5 Section 187.5 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE ENVIRONMENT ENVIRONMENTAL EFFECTS ABROAD OF MAJOR DEPARTMENT OF DEFENSE ACTIONS § 187.5 Responsibilities. (a) The Assistant Secretary...

  4. 30 CFR 18.7 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false 18.7 Section 18.7 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR TESTING, EVALUATION, AND APPROVAL OF MINING PRODUCTS ELECTRIC MOTOR-DRIVEN MINE EQUIPMENT AND ACCESSORIES General Provisions § 18.7...

  5. Evolving Important Role of Lutetium-177 for Therapeutic Nuclear Medicine.

    PubMed

    Pillai, Ambikalmajan M R; Knapp, Furn F Russ

    2015-01-01

    Lutetium-177 ((177)Lu) is a late entrant into the nuclear medicine therapy arena but is expected to become one of the most widely used therapeutic radionuclides. This paper analyses the reason for the increasing preference of (177)Lu as a therapeutic radionuclide. While the radionuclidic properties favor its use for several therapeutic applications, the potential for large scale production of (177)Lu is also an important aspect for its acceptability as a therapeutic radionuclide. This introductory discussion also summarizes some developing clinical uses and suggested future directions for applications of (177)Lu.

  6. Enhancement of lutetium texaphyrin phototherapy with Mitomycin C

    NASA Astrophysics Data System (ADS)

    Thiemann, Patricia A.; Woodburn, Kathryn W.

    1998-05-01

    Lutetium texaphyrin (Lu-Tex) photodynamic therapy (PDT) relies on the presence of the water-soluble Lu-Tex, oxygen, and light (activation around 730 nm). Cytotoxic oxygen species are produced that cause irreversible damage to biological substrates. Damage may be inflicted via direct cell kill mechanisms or through vasculature effects that cause hypoxia. The addition of hypoxia enhanced drugs, such as Mitomycin C (MMC), can potentially increase the anti-tumor response. RIF-1 bearing C3H mice received 10 micrometers ol Lu-Tex/kg and were illuminated with 100 J/cm2 3 hours postinjection. Mice received MMC (2.5 or 5 mg/kg, before and after light) in conjunction with PDT and were compared to subsets of drug alone controls. A significant improvement in PDT response was observed when MMC was added to the dosing regimen; the effect was more pronounced at the highest MMC dose of 5 mg/kg: MMC prior to PDT gave a median tumor regrowth time (10X original volume) of 28 days compared to MMC and PDT alone, 16.3 and 14.9 days, respectively. The anti-tumor activity of lutetium texaphyrin induced PDT was improved by the addition of the bioreductive alkylating agent mitomycin C.

  7. 14 CFR 61.187 - Flight proficiency.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 2 2014-01-01 2014-01-01 false Flight proficiency. 61.187 Section 61.187 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRMEN..., landings, and go-arounds; (viii) Fundamentals of flight; (ix) Performance maneuvers; (x) Ground...

  8. 27 CFR 19.187 - Pipelines.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2014-04-01 2014-04-01 false Pipelines. 19.187 Section... Package Scale and Pipeline Requirements § 19.187 Pipelines. All pipelines, including flexible hoses, that... TTB officer may approve pipelines that cannot be readily examined if they pose no jeopardy to...

  9. 27 CFR 19.187 - Pipelines.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2013-04-01 2013-04-01 false Pipelines. 19.187 Section... Package Scale and Pipeline Requirements § 19.187 Pipelines. All pipelines, including flexible hoses, that... TTB officer may approve pipelines that cannot be readily examined if they pose no jeopardy to...

  10. 27 CFR 19.187 - Pipelines.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2012-04-01 2012-04-01 false Pipelines. 19.187 Section... Package Scale and Pipeline Requirements § 19.187 Pipelines. All pipelines, including flexible hoses, that... TTB officer may approve pipelines that cannot be readily examined if they pose no jeopardy to...

  11. 27 CFR 19.187 - Pipelines.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Pipelines. 19.187 Section... Package Scale and Pipeline Requirements § 19.187 Pipelines. All pipelines, including flexible hoses, that... TTB officer may approve pipelines that cannot be readily examined if they pose no jeopardy to...

  12. 32 CFR 187.1 - Purpose.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 1 2013-07-01 2013-07-01 false Purpose. 187.1 Section 187.1 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE ENVIRONMENT ENVIRONMENTAL EFFECTS ABROAD OF MAJOR..., and nothing in it shall be construed to create a cause of action. Guidance for taking account...

  13. 15 CFR 922.187 - Interagency Cooperation.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Interagency Cooperation. 922.187... Sanctuary § 922.187 Interagency Cooperation. Under section 304(d) of the NMSA, Federal agency actions... practicable, consultation procedures under section 304(d) of the NMSA may be consolidated with...

  14. 15 CFR 922.187 - Interagency Cooperation.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 15 Commerce and Foreign Trade 3 2012-01-01 2012-01-01 false Interagency Cooperation. 922.187... Sanctuary § 922.187 Interagency Cooperation. Under section 304(d) of the NMSA, Federal agency actions... cooperation procedures required by other statutes, such as the ESA. The Director will attempt to...

  15. 15 CFR 922.187 - Interagency Cooperation.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 15 Commerce and Foreign Trade 3 2014-01-01 2014-01-01 false Interagency Cooperation. 922.187... Sanctuary § 922.187 Interagency Cooperation. Under section 304(d) of the NMSA, Federal agency actions... cooperation procedures required by other statutes, such as the ESA. The Director will attempt to...

  16. 15 CFR 922.187 - Interagency Cooperation.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 15 Commerce and Foreign Trade 3 2013-01-01 2013-01-01 false Interagency Cooperation. 922.187... Sanctuary § 922.187 Interagency Cooperation. Under section 304(d) of the NMSA, Federal agency actions... cooperation procedures required by other statutes, such as the ESA. The Director will attempt to...

  17. 15 CFR 922.187 - Interagency Cooperation.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 15 Commerce and Foreign Trade 3 2011-01-01 2011-01-01 false Interagency Cooperation. 922.187... Sanctuary § 922.187 Interagency Cooperation. Under section 304(d) of the NMSA, Federal agency actions... cooperation procedures required by other statutes, such as the ESA. The Director will attempt to...

  18. Electrochromic cells with lutetium diphthalocyanine and semisolid polymer electrolytes

    NASA Astrophysics Data System (ADS)

    Pizzarello, F. A.; Nicholson, M. M.

    1987-11-01

    Cyclic voltammograms were obtained for lutetium diphthalocyanine films in contact with plasticized poly(ethylene oxide) (PEO) electrolytes or solvent-swollen 2-acrylamido-2-methylpropane- sulfonic acid (AMPS) polymer electrolytes. Cells containing PEO-salt combinations plasticized with propylene glycol (PG) or acetonitrile resulted in slow, nonuniform color changes due to high interfacial resistance. The AMPS cell fabrication was simplified by starting with a commercial AMPS polymer product in the form of a transparent sheet containing water and other additives. This material, when further swollen in a PG-HC1 solution, produced the full range of uniform colors, accompanied by well defined voltammograms. It maintained good contact with the dye from -5 to 40 C.

  19. Lutetium-methanediide-alkyl complexes: synthesis and chemistry.

    PubMed

    Li, Shihui; Wang, Meiyan; Liu, Bo; Li, Lei; Cheng, Jianhua; Wu, Chunji; Liu, Dongtao; Liu, Jingyao; Cui, Dongmei

    2014-11-17

    The first four-coordinate methanediide/alkyl lutetium complex (BODDI)Lu2 (CH2 SiMe3 )2 (μ2 -CHSiMe3 )(THF)2 (BODDI=ArNC(Me)CHCOCHC(Me)NAr, Ar=2,6-iPr2 C6 H3 ) (1) was synthesized by a thermolysis methodology through α-H abstraction from a Lu-CH2 SiMe3 group. Complex 1 reacted with equimolar 2,6-iPrC6 H3 NH2 and Ph2 C+O to give the corresponding lutetium bridging imido and oxo complexes (BODDI)Lu2 (CH2 SiMe3 )2 (μ2 -N-2,6-iPr2 C6 H3 )(THF)2 (2) and (BODDI)Lu2 (CH2 SiMe3 )2 (μ2 -O)(THF)2 (3). Treatment of 3 with Ph2 C=O (4 equiv) caused a rare insertion of Lu-μ2 -O bond into theC=O group to afford a diphenylmethyl diolate complex 4. Reaction of 1 with PhN=C=O (2 equiv) led to the migration of SiMe3 to the amido nitrogen atom to give complex (BODDI)Lu2 (CH2 SiMe3 )2 -μ-{PhNC(O)CHC(O)NPh(SiMe3 )-κ(3) N,O,O}(THF) (5). Reaction of 1 withtBuN=C formed an unprecedented product (BODDI)Lu2 (CH2 SiMe3 ){μ2 -[η(2) :η(2) -tBuN=C(=CH2 )SiMe2 CHC=NtBu-κ(1) N]}(tBuN=C)2 (6) through a cascade reaction of N=C bond insertion, sequential cyclometalative γ-(sp(3) )-H activation, C=C bond formation, and rearrangement of the newly formed carbene intermediate. The possible mechanistic pathways between 1, PhN=C=O, and tBuN=C were elucidated by DFT calculations.

  20. Theranostic Applications of Lutetium-177 in Radionuclide Therapy.

    PubMed

    Das, Tapas; Banerjee, Sharmila

    2016-01-01

    Lutetium-177 has been widely discussed as a radioisotope of choice for targeted radionuclide therapy. The simultaneous emission of imageable gamma photons [208 keV (11%) and 113 keV (6.4%)] along with particulate β(-) emission [β(max) = 497 keV] makes it a theranostically desirable radioisotope. In the present article, the possibility of using two 177Lu-based agents viz. 177Lu-EDTMP and 177Lu-DOTATATE for theranostic applications in metastatic bone pain palliation (MBPP) and peptide receptor radionuclide therapy (PRRT), have been explored. In the case of 177Lu-EDTMP, the whole-body images obtained are compared with those recorded using 99mTc-MDP in the same patient. On the other hand, pre-therapy images acquired with 177Lu-DOTA-TATE are compared with similar images obtained with standard agents, such as 99mTc-HYNIC-TOC (SPECT) and 68Ga-DOTA-TOC (PET) in the same patient. The advantage of the long physical half-life (T1/2) of 177Lu has been utilized in mapping the pharmacokinetics of two additional agents, 177Lu-labeled hydroxyapatite (HA) in radiation synovectomy of knee joints and 177Lu-HA for therapy of hepatocellular carcinoma. Results of these multiple studies conclusively document the potential of 177Lu as a theranostic radioisotope.

  1. Synthesis and densification of lutetium pyrosilicate from lutetia and silica

    SciTech Connect

    Tripathi, Himansu S.; Sarin, Vinod K. . E-mail: sarin@bu.edu

    2007-02-15

    Cerium-doped lutetium pyrosilicate (Lu{sub 2}Si{sub 2}O{sub 7}:Ce) powder was synthesized by solid state reaction of Lu{sub 2}O{sub 3} and SiO{sub 2}. Stoichiometric mixtures of the starting materials were heat treated at various different temperatures and their phase contents were measured by XRD technique. It was found that the first step in the formation of Lu{sub 2}Si{sub 2}O{sub 7} (LPS) is the appearance of Lu{sub 2}SiO{sub 5} (LSO). This takes place at 1100 deg. C, fully 300 deg. C below the first appearance of LPS. Between 1400 and 1500 deg. C both LSO and LPS coexist in the calcined batch, but by 1550 deg. C all LSO is completely converted to LPS. LPS formation temperature does not have appreciable effect on the density of the hot pressed samples. Hot pressed samples obtained from powder synthesized at 1650 deg. C are nearly transparent, although the particle size of the starting powder is higher than that of the powder formed at lower temperatures.

  2. A cascade reaction: ring-opening insertion of dioxaphospholane into lutetium alkyl bonds.

    PubMed

    Johnson, Kevin R D; Hayes, Paul G

    2014-02-14

    Geometrically constrained dioxaphospholane rings were incorporated into a bis(phosphinimine)carbazole ligand (HL) in an effort to generate an ancillary ligand system that is capable of supporting reactive lutetium alkyl functionalities and resistant to cyclometalation reactivity. This new ligand was used to prepare a lutetium dialkyl species, LLu(CH2SiMe3)2; however, the complex exhibited low thermal stability at ambient temperature. This dialkyl compound was found to be highly susceptible to a cascading inter- and intramolecular reaction that resulted in the sole formation of an asymmetric bimetallic tetraalkoxide complex. The product of this reaction, generated by the ring-opening insertion of dioxaphospholane moieties into lutetium-carbon bonds, was characterized by multinuclear NMR spectroscopy and single crystal X-ray diffraction.

  3. 49 CFR 37.187 - Interline service.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... DISABILITIES (ADA) Over-the-Road Buses (OTRBs) § 37.187 Interline service. (a) When the general public can... which another operator provides service, the first operator must arrange for an accessible bus, or... Point A through to Point C, transferring at intermediate Point B to a bus operated by Operator...

  4. 49 CFR 37.187 - Interline service.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... DISABILITIES (ADA) Over-the-Road Buses (OTRBs) § 37.187 Interline service. (a) When the general public can... which another operator provides service, the first operator must arrange for an accessible bus, or... Point A through to Point C, transferring at intermediate Point B to a bus operated by Operator...

  5. 49 CFR 37.187 - Interline service.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... DISABILITIES (ADA) Over-the-Road Buses (OTRBs) § 37.187 Interline service. (a) When the general public can... which another operator provides service, the first operator must arrange for an accessible bus, or... Point A through to Point C, transferring at intermediate Point B to a bus operated by Operator...

  6. 49 CFR 37.187 - Interline service.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... DISABILITIES (ADA) Over-the-Road Buses (OTRBs) § 37.187 Interline service. (a) When the general public can... which another operator provides service, the first operator must arrange for an accessible bus, or... Point A through to Point C, transferring at intermediate Point B to a bus operated by Operator...

  7. 49 CFR 37.187 - Interline service.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... DISABILITIES (ADA) Over-the-Road Buses (OTRBs) § 37.187 Interline service. (a) When the general public can... which another operator provides service, the first operator must arrange for an accessible bus, or... Point A through to Point C, transferring at intermediate Point B to a bus operated by Operator...

  8. 50 CFR 300.187 - Validation requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 9 2011-10-01 2011-10-01 false Validation requirements. 300.187 Section... Validation requirements. (a) Imports. The approved consignment document accompanying any import of any fish... will furnish a list of countries for which government validation requirements are waived to...

  9. 50 CFR 300.187 - Validation requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Validation requirements. 300.187 Section... Validation requirements. (a) Imports. The approved consignment document accompanying any import of any fish... will furnish a list of countries for which government validation requirements are waived to...

  10. Magneto-optical property of terbium-lutetium-aluminum garnet crystals

    NASA Astrophysics Data System (ADS)

    Man, Peiwen; Ma, Fengkai; Xie, Tao; Ding, Jingxin; Wu, Anhua; Su, Liangbi; Li, Huanying; Ren, Guohao

    2017-04-01

    Mixed terbium lutetium aluminum garnet Tb2.2Lu0.8Al5O12 (LuTAG) single crystal was grown by Czochralski technique successfully. The structure had been analyzed by X-ray diffraction. The paramagnetic behavior was observed in magnetic measurement. Magneto-optical properties and thermal conductivity of LuTAG had been studied in detail and compared with these of TGG sample. The crystal exhibited a high thermal conductivity and very high transmittance, particularly in visible and near-infrared region, indicating terbium-lutetium-aluminum garnet could be a potential magneto-optical material using in high-power laser system.

  11. Lutetium-doped EuO films grown by molecular-beam epitaxy

    SciTech Connect

    Melville, A.; Heeg, T.; Mairoser, T.; Schmehl, A.; Shai, D. E.; Monkman, E. J.; Harter, J. W.; Hollaender, B.; Schubert, J.; Shen, K. M.; Mannhart, J.; Schlom, D. G.

    2012-05-28

    The effect of lutetium doping on the structural, electronic, and magnetic properties of epitaxial EuO thin films grown by reactive molecular-beam epitaxy is experimentally investigated. The behavior of Lu-doped EuO is contrasted with doping by lanthanum and gadolinium. All three dopants are found to behave similarly despite differences in electronic configuration and ionic size. Andreev reflection measurements on Lu-doped EuO reveal a spin-polarization of 96% in the conduction band, despite non-magnetic carriers introduced by 5% lutetium doping.

  12. Novel lutetium spectroscopic interactions via cw RIMS (Resonance Ionization Mass Spectrometry)

    SciTech Connect

    Fearey, B.L.; Miller, C.M.

    1989-01-01

    Novel spectroscopic interactions of argon-ion laser enhanced resonance ionization of lutetium are observed and discussed; these include line-narrowing, non-linear power dependences and anomalous optical pumping effects of the hyperfine transitions. In addition, isotopically saturation dip spectra are observed and presented, allowing for precise determination of hyperfine constants of rare isotopes. 12 refs., 2 figs.

  13. Lutetium-177 DOTATATE Production with an Automated Radiopharmaceutical Synthesis System

    PubMed Central

    Aslani, Alireza; Snowdon, Graeme M; Bailey, Dale L; Schembri, Geoffrey P; Bailey, Elizabeth A; Pavlakis, Nick; Roach, Paul J

    2015-01-01

    Objective(s): Peptide Receptor Radionuclide Therapy (PRRT) with yttrium-90 (90Y) and lutetium-177 (177Lu)-labelled SST analogues are now therapy option for patients who have failed to respond to conventional medical therapy. In-house production with automated PRRT synthesis systems have clear advantages over manual methods resulting in increasing use in hospital-based radiopharmacies. We report on our one year experience with an automated radiopharmaceutical synthesis system. Methods: All syntheses were carried out using the Eckert & Ziegler Eurotope’s Modular-Lab Pharm Tracer® automated synthesis system. All materials and methods used were followed as instructed by the manufacturer of the system (Eckert & Ziegler Eurotope, Berlin, Germany). Sterile, GMP-certified, no-carrier added (NCA) 177Lu was used with GMP-certified peptide. An audit trail was also produced and saved by the system. The quality of the final product was assessed after each synthesis by ITLC-SG and HPLC methods. Results: A total of 17 [177Lu]-DOTATATE syntheses were performed between August 2013 and December 2014. The amount of radioactive [177Lu]-DOTATATE produced by each synthesis varied between 10-40 GBq and was dependant on the number of patients being treated on a given day. Thirteen individuals received a total of 37 individual treatment administrations in this period. There were no issues and failures with the system or the synthesis cassettes. The average radiochemical purity as determined by ITLC was above 99% (99.8 ± 0.05%) and the average radiochemical purity as determined by HPLC technique was above 97% (97.3 ± 1.5%) for this period. Conclusions: The automated synthesis of [177Lu]-DOTATATE using Eckert & Ziegler Eurotope’s Modular-Lab Pharm Tracer® system is a robust, convenient and high yield approach to the radiolabelling of DOTATATE peptide benefiting from the use of NCA 177Lu and almost negligible radiation exposure of the operators. PMID:27408890

  14. 187Re - 187Os Nuclear Geochronometry: A New Dating Method Applied to Old Ores

    NASA Astrophysics Data System (ADS)

    Roller, Goetz

    2015-04-01

    187Re - 187Os nuclear geochronometry is a newly developed dating method especially (but not only) for PGE hosting magmatic ore deposits. It combines ideas of nuclear astrophysics with geochronology. For this, the concept of sudden nucleosynthesis [1-3] is used to calculate so-called nucleogeochronometric Rhenium-Osmium two-point-isochrone (TPI) ages. Here, the method is applied to the Sudbury Igneous Complex (SIC) and the Stillwater Complex (SC), using a set of two nuclear geochronometers. They are named the BARBERTON ( Re/Os = 0.849, 187Os/186Os = 10.04 ± 0.015 [4]) and the IVREA (Re/Os = 0.951, 187Os/186Os = 1.9360 ± 0.0015 [5]) nuclear geochronometer. Calculated TPI ages are consistent with results from Sm-Nd geochronology, a previously published Re-Os Molybdenum age of 2740 ± 80 Ma for the G-chromitite of the SC [6] and a Re-Os isochrone age of 1689 ± 160 Ma for the Strathcona ores of the SIC [7]. This leads to an alternative explanation of the peculiar and enigmatic 187Os/186Osi isotopic signatures reported from both ore deposits. For example, for a TPI age of 2717 ± 100 Ma the Ultramafic Series of the SC contains both extremely low (subchrondritic) 187Os/186Osi ratios (187Os/186Osi = 0.125 ± 0.067) and extremely radiogenic isotopic signatures (187Os/186Osi = 6.55 ± 1.7, [6]) in mineral separates (chromites) and whole rock samples, respectively. Within the Strathcona ores of the SIC, even more pronounced radiogenic 187Os/186Os initial ratios can be calculated for TPI ages between 1586 ± 63 Ma (187Os/186Osi = 8.998 ± 0.045) and 1733 ± 84 Ma (187Os/186Osi = 8.901 ± 0.059). These results are in line with the recalculated Re-Os isochrone age of 1689 ± 160 Ma (187Os/186Osi = 8.8 ± 2.3 [7]). In the light of nuclear geochronometry, the occurrence of such peculiar isotopic 187Os/186Osi signatures within one and the same lithological horizon are plausible if explained by mingling of the two nucleogeochronometric (BARBERTON and IVREA) reservoirs containing

  15. 25 CFR 700.187 - Utilization of replacement home benefits.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 2 2014-04-01 2014-04-01 false Utilization of replacement home benefits. 700.187 Section 700.187 Indians THE OFFICE OF NAVAJO AND HOPI INDIAN RELOCATION COMMISSION OPERATIONS AND RELOCATION PROCEDURES Replacement Housing Payments § 700.187 Utilization of replacement home benefits. The...

  16. 25 CFR 700.187 - Utilization of replacement home benefits.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 2 2011-04-01 2011-04-01 false Utilization of replacement home benefits. 700.187 Section 700.187 Indians THE OFFICE OF NAVAJO AND HOPI INDIAN RELOCATION COMMISSION OPERATIONS AND RELOCATION PROCEDURES Replacement Housing Payments § 700.187 Utilization of replacement home benefits. The...

  17. 25 CFR 700.187 - Utilization of replacement home benefits.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false Utilization of replacement home benefits. 700.187 Section 700.187 Indians THE OFFICE OF NAVAJO AND HOPI INDIAN RELOCATION COMMISSION OPERATIONS AND RELOCATION PROCEDURES Replacement Housing Payments § 700.187 Utilization of replacement home benefits. The...

  18. 25 CFR 700.187 - Utilization of replacement home benefits.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 2 2013-04-01 2013-04-01 false Utilization of replacement home benefits. 700.187 Section 700.187 Indians THE OFFICE OF NAVAJO AND HOPI INDIAN RELOCATION COMMISSION OPERATIONS AND RELOCATION PROCEDURES Replacement Housing Payments § 700.187 Utilization of replacement home benefits. The...

  19. 25 CFR 700.187 - Utilization of replacement home benefits.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 2 2012-04-01 2012-04-01 false Utilization of replacement home benefits. 700.187 Section 700.187 Indians THE OFFICE OF NAVAJO AND HOPI INDIAN RELOCATION COMMISSION OPERATIONS AND RELOCATION PROCEDURES Replacement Housing Payments § 700.187 Utilization of replacement home benefits. The...

  20. Heteroleptic naphthalo-phthalocyaninates of lutetium: synthesis and spectral and conductivity properties.

    PubMed

    Dubinina, Tatiana V; Kosov, Anton D; Petrusevich, Elizaveta F; Maklakov, Sergey S; Borisova, Nataliya E; Tomilova, Larisa G; Zefirov, Nikolay S

    2015-05-07

    Novel heteroleptic naphthalo-phthalocyaninates of lutetium possessing a symmetrical substituted naphthalocyanine deck were synthesized on the basis of two preformed synthetic blocks: naphthalocyanine ligand and lutetium phthalocyaninates. The compounds obtained were characterized by (1)H NMR and high-resolution MALDI-TOF/TOF mass spectrometry. The correlation between the nature of the substituents and the spectral properties of the target complexes was determined by the introduction of electron-donating (aryl-, aryloxy-) or electron-withdrawing (chloro-) substituents into the phthalocyanine deck. In addition, the nature of peripheral substituents was shown not to affect drastically the phthalocyanine conductivity and activation energy. Conductivity properties depend on thin film morphology which, in turn, relies on intermolecular π-π interactions.

  1. Novel functionalized mesopore of SBA-15 as prospective sorbent for praseodymium and lutetium.

    PubMed

    Mallah, M H; Ghannadi Maragheh, M; Badiei, A; Habibzadeh Sbo, R

    In the present work, results of γ-irradiation on normal and functionalized SBA-15 by aurintricarboxylic acid have been reported. Characterization of normal and functionalized SBA-15 particles before and after γ-irradiation was carried out using Fourier-transform infrared technique. Aurintricarboxylic acid ligand connected to SBA-15 was also analyzed using UV/Vis spectrophotometer. The modified sorbent was then used as a new sorbent for separation of trace amounts of praseodymium and lutetium ions from nuclear waste waters in batch techniques. Based on the results of distribution coefficients determination, and investigation of sorption process in various conditions, the parameters were optimized for separation lanthanides. It can be concluded that the functionalized SBA-15 is a promising sorbent for praseodymium and lutetium cations.

  2. de Haas--van Alphen effect and Fermi surface of lutetium

    SciTech Connect

    Johanson, W.R.; Crabtree, G.W.; Schmidt, F.A.

    1984-03-01

    We report de Haas--van Alphen measurements of the Fermi surface of lutetium at temperatures down to 0.3 K and in fields up to 150 kG in the (1010) and (1120) planes. Lutetium, having a filled 4f shell, serves as a nonmagnetic prototype of the structurally similar (hcp), trivalent, heavy rare-earth elements from Gd to Tm. The fact that no complete frequency branches were observed indicates that there are no closed pieces of the Fermi surface. We observed all but one orbit predicted by relativistic augmented-plane-wave calculations of Keeton and Loucks and by recent spin-orbit--linearized-augmented-plane-wave calculations of Tibbetts and Harmon. The data support a geometry similar to that of yttrium, and in good qualitative agreement with energy-band theory.

  3. de Haas-van Alphen effect and Fermi surface of lutetium

    NASA Astrophysics Data System (ADS)

    Johanson, W. R.; Crabtree, G. W.; Schmidt, F. A.

    1984-03-01

    We report de Haas-van Alphen measurements of the Fermi surface of lutetium at temperatures down to 0.3 K and in fields up to 150 kG in the (101¯0) and (112¯0) planes. Lutetium, having a filled 4f shell, serves as a nonmagnetic prototype of the structurally similar (hcp), trivalent, heavy rare-earth elements from Gd to Tm. The fact that no complete frequency branches were observed indicates that there are no closed pieces of the Fermi surface. We observed all but one orbit predicted by relativistic augmented-plane-wave calculations of Keeton and Loucks and by recent spin-orbit-linearized-augmented-plane-wave calculations of Tibbetts and Harmon. The data support a geometry similar to that of yttrium, and in good qualitative agreement with energy-band theory.

  4. Properties of Ce-activated alkali-lutetium double phosphate scintillators

    SciTech Connect

    Wiśniewski, D.; Wojtowicz, A. J.; Boatner, Lynn A

    2010-01-01

    The scintillation properties of Ce-activated alkali-lutetium double phosphate single crystals that vary with the alkali ion type and activation level are summarized and compared. The materials investigated here have been identified as fast and efficient scintillators for the detection of x-ray and radiation, and in case of Li3Lu(PO4)2:Ce, for thermal neutron detection as well.

  5. Heat capacity and thermal expansion of icosahedral lutetium boride LuB66

    SciTech Connect

    Novikov, V V; Avdashchenko, D V; Matovnikov, A V; Mitroshenkov, N V; Bud’ko, S L

    2014-01-07

    The experimental values of heat capacity and thermal expansion for lutetium boride LuB66 in the temperature range of 2-300 K were analysed in the Debye-Einstein approximation. It was found that the vibration of the boron sub-lattice can be considered within the Debye model with high characteristic temperatures; low-frequency vibration of weakly connected metal atoms is described by the Einstein model.

  6. Lutetium(iii) aqua ion: On the dynamical structure of the heaviest lanthanoid hydration complex.

    PubMed

    Sessa, Francesco; Spezia, Riccardo; D'Angelo, Paola

    2016-05-28

    The structure and dynamics of the lutetium(iii) ion in aqueous solution have been investigated by means of a polarizable force field molecular dynamics (MD). An 8-fold square antiprism (SAP) geometry has been found to be the dominant configuration of the lutetium(iii) aqua ion. Nevertheless, a low percentage of 9-fold complexes arranged in a tricapped trigonal prism (TTP) geometry has been also detected. Dynamic properties have been explored by carrying out six independent MD simulations for each of four different temperatures: 277 K, 298 K, 423 K, 632 K. The mean residence time of water molecules in the first hydration shell at room temperature has been found to increase as compared to the central elements of the lanthanoid series in agreement with previous experimental findings. Water exchange kinetic rate constants at each temperature and activation parameters of the process have been determined from the MD simulations. The obtained structural and dynamical results suggest that the water exchange process for the lutetium(iii) aqua ion proceeds with an associative mechanism, in which the SAP hydration complex undergoes temporary structural changes passing through a 9-fold TTP intermediate. Such results are consistent with the water exchange mechanism proposed for heavy lanthanoid atoms.

  7. Biomimetic biosensor based on lipidic layers containing tyrosinase and lutetium bisphthalocyanine for the detection of antioxidants.

    PubMed

    Apetrei, C; Alessio, P; Constantino, C J L; de Saja, J A; Rodriguez-Mendez, M L; Pavinatto, F J; Ramos Fernandes, E Giuliani; Zucolotto, V; Oliveira, O N

    2011-01-15

    This paper describes the preparation of a biomimetic Langmuir-Blodgett film of tyrosinase incorporated in a lipidic layer and the use of lutetium bisphthalocyanine as an electron mediator for the voltammetric detection of phenol derivatives, which include one monophenol (vanillic acid), two diphenols (catechol and caffeic acid) and two triphenols (gallic acid and pyrogallol). The first redox process of the voltammetric responses is associated with the reduction of the enzymatically formed o-quinone and is favoured by the lutetium bisphthalocyanine because significant signal amplification is observed, while the second is associated with the electrochemical oxidation of the antioxidant and occurs at lower potentials in the presence of an electron mediator. The biosensor shows low detection limit (1.98×10(-6)-27.49×10(-6) M), good reproducibility, and high affinity to antioxidants (K(M) in the range of 62.31-144.87 μM). The excellent functionality of the enzyme obtained using a biomimetic immobilisation method, the selectivity afforded by enzyme catalysis, the signal enhancement caused by the lutetium bisphthalocyanine mediator and the increased selectivity of the curves due to the occurrence of two redox processes make these sensors exceptionally suitable for the detection of phenolic compounds.

  8. Absolute peptide quantification by lutetium labeling and nanoHPLC-ICPMS with isotope dilution analysis.

    PubMed

    Rappel, Christina; Schaumlöffel, Dirk

    2009-01-01

    The need of analytical methods for absolute quantitative protein analysis spurred research on new developments in recent years. In this work, a novel approach was developed for accurate absolute peptide quantification based on metal labeling with lutetium diethylenetriamine pentaacetic acid (Lu-DTPA) and nanoflow high-performance liquid chromatography-inductively coupled plasma isotope dilution mass spectrometry (nanoHPLC-ICP-IDMS). In a two-step procedure peptides were derivatized at amino groups with diethylenetriamine pentaacetic anhydride (DTPAA) followed by chelation of lutetium. Electrospray ionization mass spectrometry (ESI MS) of the reaction product demonstrated highly specific peptide labeling. Under optimized nanoHPLC conditions the labeled peptides were baseline-separated, and the excess labeling reagent did not interfere. A 176Lu-labeled spike was continuously added to the column effluent for quantification by ICP-IDMS. The recovery of a Lu-DTPA-labeled standard peptide was close to 100% indicating high labeling efficiency and accurate absolute quantification. The precision of the entire method was 4.9%. The detection limit for Lu-DTPA-tagged peptides was 179 amol demonstrating that lutetium-specific peptide quantification was by 4 orders of magnitude more sensitive than detection by natural sulfur atoms present in cysteine or methionine residues. Furthermore, the application to peptides in insulin tryptic digest allowed the identification of interfering reagents decreasing the labeling efficiency. An additional advantage of this novel approach is the analysis of peptides, which do not naturally feature ICPMS-detectable elements.

  9. Lutetium(iii) aqua ion: On the dynamical structure of the heaviest lanthanoid hydration complex

    NASA Astrophysics Data System (ADS)

    Sessa, Francesco; Spezia, Riccardo; D'Angelo, Paola

    2016-05-01

    The structure and dynamics of the lutetium(iii) ion in aqueous solution have been investigated by means of a polarizable force field molecular dynamics (MD). An 8-fold square antiprism (SAP) geometry has been found to be the dominant configuration of the lutetium(iii) aqua ion. Nevertheless, a low percentage of 9-fold complexes arranged in a tricapped trigonal prism (TTP) geometry has been also detected. Dynamic properties have been explored by carrying out six independent MD simulations for each of four different temperatures: 277 K, 298 K, 423 K, 632 K. The mean residence time of water molecules in the first hydration shell at room temperature has been found to increase as compared to the central elements of the lanthanoid series in agreement with previous experimental findings. Water exchange kinetic rate constants at each temperature and activation parameters of the process have been determined from the MD simulations. The obtained structural and dynamical results suggest that the water exchange process for the lutetium(iii) aqua ion proceeds with an associative mechanism, in which the SAP hydration complex undergoes temporary structural changes passing through a 9-fold TTP intermediate. Such results are consistent with the water exchange mechanism proposed for heavy lanthanoid atoms.

  10. 187Re - 187Os nuclear geochronometry: age dating with permil precision

    NASA Astrophysics Data System (ADS)

    Roller, Goetz

    2016-04-01

    Recently, 187Re - 187Os nuclear geochronometry, a new dating method combining ideas of nuclear astrophysics with geochronology, has successfully been used to calculate two-point-isochron (TPI) ages for Devonian black gas shales using the isotopic signature of an r-process geochronometer as one data point in a TPI diagram [1]. Based upon a nuclear production ratio 187Re/188Os = 5.873, TPI ages were calculated for 12 SDO-1 (Devonian Ohio Shale, Appalachian Basin) aliquants, for which repeated Re-Os measurements are reported in the literature [2]. TPI ages range from 384.5 ± 2.7 Ma (187Os/188Osi = 0.29413 ± 0.00023) to 387.7 ± 2.1 Ma (187Os/188Osi = 0.29407 ± 0.00019) with a mean of 386.67 ± 1.79 Ma). The result is consistent with the isochronous age from the 12 aliquants alone (386 ± 16 Ma, 187Os/188Osi = 0.31±0.31), which is bracketed by U-Pb ages for the Belpre Ash (381.1 ± 3.3 Ma) and the Tioga Ash bed (390.0 ± 2.5 Ma) [3] from the Appalachian Basin. Hence, SDO-1 can be assigned to the Givetian stage (varcus-zone) of the Middle Devonian, close to the Eifelian/Givetian boundary (using the time-scale of [3] or [4]). If an age is calculated from an isochron diagram for the 12 aliquants including the nuclear geochronometer, a permil precision can be achieved, an interesting feature with respect to any effort towards calibrating the Geologic Timescale. Additionally, a Th/U evolution (or: Th/U-time) diagram can be plotted using U-Pb zircon age data and Th/U ratios from volcanic rocks and ashes reported in the literature [3] for specific Devonian samples from the Appalachian Basin. Since the Re-Os age obtained for SDO-1 can also be connected to its Th/U ratio, it turns out, that Th/U ratios might be helpful age indicators, as demonstrated for the Devonian using the U-Pb and Re-Os datasets. [1] Roller (2015), GSA Abstr. with Programs 47, #248-14. [2] Du Vivier et al. (2014), Earth Planet. Sci. Lett. 389, 23 - 33. [3] Tucker et al. (1998), Earth Planet. Sci. Lett

  11. Comparative 187Re-187Os systematics of chondrites: Implications regarding early solar system processes

    USGS Publications Warehouse

    Walker, R.J.; Horan, M.F.; Morgan, J.W.; Becker, H.; Grossman, J.N.; Rubin, A.E.

    2002-01-01

    A suite of 47 carbonaceous, enstatite, and ordinary chondrites are examined for Re-Os isotopic systematics. There are significant differences in the 187Re/188Os and 187Os/188Os ratios of carbonaceous chondrites compared with ordinary and enstatite chondrites. The average 187Re/188Os for carbonaceous chondrites is 0.392 ?? 0.015 (excluding the CK chondrite, Karoonda), compared with 0.422 ?? 0.025 and 0.421 ?? 0.013 for ordinary and enstatite chondrites (1?? standard deviations). These ratios, recast into elemental Re/Os ratios, are as follows: 0.0814 ?? 0.0031, 0.0876 ?? 0.0052 and 0.0874 ?? 0.0027 respectively. Correspondingly, the 187Os/188Os ratios of carbonaceous chondrites average 0.1262 ?? 0.0006 (excluding Karoonda), and ordinary and enstatite chondrites average 0.1283 ?? 0.0017 and 0.1281 ?? 0.0004, respectively (1?? standard deviations). The new results indicate that the Re/Os ratios of meteorites within each group are, in general, quite uniform. The minimal overlap between the isotopic compositions of ordinary and enstatite chondrites vs. carbonaceous chondrites indicates long-term differences in Re/Os for these materials, most likely reflecting chemical fractionation early in solar system history. A majority of the chondrites do not plot within analytical uncertainties of a 4.56-Ga reference isochron. Most of the deviations from the isochron are consistent with minor, relatively recent redistribution of Re and/or Os on a scale of millimeters to centimeters. Some instances of the redistribution may be attributed to terrestrial weathering; others are most likely the result of aqueous alteration or shock events on the parent body within the past 2 Ga. The 187Os/188Os ratio of Earth's primitive upper mantle has been estimated to be 0.1296 ?? 8. If this composition was set via addition of a late veneer of planetesimals after core formation, the composition suggests the veneer was dominated by materials that had Re/Os ratios most similar to ordinary and

  12. VMT forecasting and tracking guidance, Section 187

    SciTech Connect

    Not Available

    1992-01-01

    The guidance is required by Section 187 (a) of the Clean Air Act Amendments of 1990. It offers the Environmental Protection Agency's (EPA's) recommendations on how to forecast and track vehicle miles traveled (VMT) in Moderate and Serious carbon monoxide (CO) non-attainment areas with design values greater than 12.7 ppm at the time of classification. The purpose of the guidance is to help states prepare State Implementation Plan (SIP) revisions that EPA can readily propose to approve as meeting the requirements of the Clean Air Act Amendments. If a state adheres to the guidance, EPA will propose approval of its SIP. A state intending to depart from the guidance, however, should show that the alternative approach it proposes is technically sound and adequate to meet the requirements of the Clean Air Act Amendments. EPA will review SIP submittals from such states on a case-by-case basis to determine whether they do in fact comply with the Clean Air Act Amendment requirements. States are encouraged to obtain EPA approval before using methods other than those specified in the guidance, in order to avoid later problems.

  13. 47 CFR 73.187 - Limitation on daytime radiation.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 4 2013-10-01 2013-10-01 false Limitation on daytime radiation. 73.187 Section... BROADCAST SERVICES AM Broadcast Stations § 73.187 Limitation on daytime radiation. (a)(1) Except as..., subsequent changes of facilities which do not involve a change in frequency, an increase in radiation...

  14. 47 CFR 73.187 - Limitation on daytime radiation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 4 2011-10-01 2011-10-01 false Limitation on daytime radiation. 73.187 Section... BROADCAST SERVICES AM Broadcast Stations § 73.187 Limitation on daytime radiation. (a)(1) Except as..., subsequent changes of facilities which do not involve a change in frequency, an increase in radiation...

  15. 47 CFR 73.187 - Limitation on daytime radiation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 4 2010-10-01 2010-10-01 false Limitation on daytime radiation. 73.187 Section... BROADCAST SERVICES AM Broadcast Stations § 73.187 Limitation on daytime radiation. (a)(1) Except as..., subsequent changes of facilities which do not involve a change in frequency, an increase in radiation...

  16. 47 CFR 73.187 - Limitation on daytime radiation.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 4 2014-10-01 2014-10-01 false Limitation on daytime radiation. 73.187 Section... BROADCAST SERVICES AM Broadcast Stations § 73.187 Limitation on daytime radiation. (a)(1) Except as..., subsequent changes of facilities which do not involve a change in frequency, an increase in radiation...

  17. 47 CFR 73.187 - Limitation on daytime radiation.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 4 2012-10-01 2012-10-01 false Limitation on daytime radiation. 73.187 Section... BROADCAST SERVICES AM Broadcast Stations § 73.187 Limitation on daytime radiation. (a)(1) Except as..., subsequent changes of facilities which do not involve a change in frequency, an increase in radiation...

  18. 33 CFR Appendix A to Part 187 - Participating Authorities

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Participating Authorities A Appendix A to Part 187 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) BOATING SAFETY VESSEL IDENTIFICATION SYSTEM Pt. 187, App. A Appendix A to Part...

  19. 49 CFR 192.187 - Vaults: Sealing, venting, and ventilation.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 3 2014-10-01 2014-10-01 false Vaults: Sealing, venting, and ventilation. 192.187... Components § 192.187 Vaults: Sealing, venting, and ventilation. Each underground vault or closed top pit... ventilating effect of a pipe 4 inches (102 millimeters) in diameter; (2) The ventilation must be enough...

  20. 49 CFR 192.187 - Vaults: Sealing, venting, and ventilation.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 3 2012-10-01 2012-10-01 false Vaults: Sealing, venting, and ventilation. 192.187... Components § 192.187 Vaults: Sealing, venting, and ventilation. Each underground vault or closed top pit... ventilating effect of a pipe 4 inches (102 millimeters) in diameter; (2) The ventilation must be enough...

  1. 40 CFR 96.187 - Change in regulatory status.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Change in regulatory status. 96.187 Section 96.187 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NOX BUDGET TRADING PROGRAM AND CAIR NOX AND SO2 TRADING PROGRAMS FOR STATE IMPLEMENTATION...

  2. 40 CFR 96.187 - Change in regulatory status.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 21 2011-07-01 2011-07-01 false Change in regulatory status. 96.187 Section 96.187 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NOX BUDGET TRADING PROGRAM AND CAIR NOX AND SO2 TRADING PROGRAMS FOR STATE IMPLEMENTATION...

  3. 49 CFR 192.187 - Vaults: Sealing, venting, and ventilation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Vaults: Sealing, venting, and ventilation. 192.187... TRANSPORTATION OF NATURAL AND OTHER GAS BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Design of Pipeline Components § 192.187 Vaults: Sealing, venting, and ventilation. Each underground vault or closed top...

  4. 33 CFR Appendix A to Part 187 - Participating Authorities

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Participating Authorities A Appendix A to Part 187 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) BOATING SAFETY VESSEL IDENTIFICATION SYSTEM Pt. 187, App. A Appendix A to Part...

  5. 43 CFR 30.187 - May I revoke my renunciation?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... irrevocable after the judge enters the final order in the probate proceeding. A revocation will not be... 43 Public Lands: Interior 1 2012-10-01 2011-10-01 true May I revoke my renunciation? 30.187 Section 30.187 Public Lands: Interior Office of the Secretary of the Interior INDIAN PROBATE...

  6. 43 CFR 30.187 - May I revoke my renunciation?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... irrevocable after the judge enters the final order in the probate proceeding. A revocation will not be... 43 Public Lands: Interior 1 2011-10-01 2011-10-01 false May I revoke my renunciation? 30.187 Section 30.187 Public Lands: Interior Office of the Secretary of the Interior INDIAN PROBATE...

  7. 43 CFR 30.187 - May I revoke my renunciation?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... irrevocable after the judge enters the final order in the probate proceeding. A revocation will not be... 43 Public Lands: Interior 1 2014-10-01 2014-10-01 false May I revoke my renunciation? 30.187 Section 30.187 Public Lands: Interior Office of the Secretary of the Interior INDIAN PROBATE...

  8. 43 CFR 30.187 - May I revoke my renunciation?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... irrevocable after the judge enters the final order in the probate proceeding. A revocation will not be... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false May I revoke my renunciation? 30.187 Section 30.187 Public Lands: Interior Office of the Secretary of the Interior INDIAN PROBATE...

  9. 43 CFR 30.187 - May I revoke my renunciation?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... irrevocable after the judge enters the final order in the probate proceeding. A revocation will not be... 43 Public Lands: Interior 1 2013-10-01 2013-10-01 false May I revoke my renunciation? 30.187 Section 30.187 Public Lands: Interior Office of the Secretary of the Interior INDIAN PROBATE...

  10. 33 CFR Appendix A to Part 187 - Participating Authorities

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Participating Authorities A Appendix A to Part 187 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) BOATING SAFETY VESSEL IDENTIFICATION SYSTEM Pt. 187, App. A Appendix A to Part...

  11. 33 CFR Appendix A to Part 187 - Participating Authorities

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Participating Authorities A Appendix A to Part 187 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) BOATING SAFETY VESSEL IDENTIFICATION SYSTEM Pt. 187, App. A Appendix A to Part...

  12. 19 CFR 122.187 - Revocation or suspension of access.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... operations at the Customs Management Center having jurisdiction over the office of the port director for a... 19 Customs Duties 1 2010-04-01 2010-04-01 false Revocation or suspension of access. 122.187 Section 122.187 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND...

  13. Synthesis of Lutetium Phosphate/Apoferritin Core-Shell Nanoparticles for Potential Applications in Radioimmunoimaging and Radioimmunotherapy of Cancers

    SciTech Connect

    Wu, Hong; Engelhard, Mark H.; Wang, Jun; Fisher, Darrell R.; Lin, Yuehe

    2008-04-01

    We report a novel approach for synthesizing LuPO4/apoferritin core-shell nanoparticles based on an apoferritin template, conjugated to the protein biotin. To prepare the nanoparticle conjugates, we used non-radioactive lutetium as a model target or surrogate for radiolutetium (177Lu). The central cavity, multi-channel structure, and chemical properties of apoferritin are well-suited for sequentially diffusing lutetium and phosphate ions into the cavity--resulting in a stable core-shell composite. We characterized the synthesized LuPO4/apoferritin nanoparticle using transmission electron microscopy (TEM) and x-ray photoelectron spectroscopy (XPS). We tested the pre-targeting capability of biotin-modified lutetium/apoferritin nanoparticle using streptavidin-modified magnetic beads and streptavidin-modified fluorescein isothiocyanate (FITC) tracer. This paper presents a simple, fast, and efficient method for synthesizing LuPO4/apoferritin nanoparticle conjugates with biotin for potential applications in radioimmunotherapy and radioimmunoimaging of cancer.

  14. 187Re- 187Os Nuclear Geochronometry: Dating Peridotitic Diamond Sulphide Inclusions

    NASA Astrophysics Data System (ADS)

    Roller, Goetz

    2015-04-01

    Nuclear geochronometry [1-2] is a new dating method which combines principles of geochronology with nuclear astrophysics. It is embedded in other scientific fields like cosmochemistry, cosmology and nuclear theory, which pose tight constraints for nuclear geochronometry. It is based upon identified Re/Os element ratios ˜ 1, interpreted as the nuclear production ratio, and ultra-subchondritic initial 187Os/188Os ratios within terrestrial rocks, suggesting that Earth's core still contains element ratios and isotopic signatures of at least two rapid (r) neutron-capture process [3] events. The 13.78 Ga old component, represented by the isotopic signature of a komatiitic basalt [5085 BasKom] [4] from the Barberton Greenstone Belt (Onverwacht Group, South Africa), is assigned to the Earth's inner core. The other isotopic signatures identified so far within pyroxenites / komatiites are assigned to its outer core due to at least one gravitational collapse of the old component, commencing ˜ 3.48 Ga [2] and resulting in one or more additional r-process event(s). Here I show that 187Re-187Os nuclear geochronometry can also be successfully applied for dating peridotitic diamond sulphide inclusions by means of two-point-isochrones (TPI), using a so-called nuclear geochronometer always as the second data point in a TPI diagram. It turns out that the method may have a huge potential to constrain the chemical evolution of the SCLM. For example, TPI ages for Ellendale (Australia) peridotitic diamond sulphide inclusions EL50, EL23, EL54-1, EL54-3, EL55-1 and EL65 reported in the literature [5] reveal at least two main fractionation events. The age cluster between 1.4 Ga and 1.5 Ga is consistent with a previously reported isochrone age [5]. The event ˜ 2.3 ± 0.3 Ga overlaps the Great Oxidation Event (GOE) between 2.22 Ga and 2.46 Ga. While the ˜ 1.4 Ga to 1.5 Ga events lead to fractionation of the 187Re/188Os ratios towards values typical for mantle peridotite, the latter caused

  15. Phase I trial of motexafin-lutetium-mediated interstitial photodynamic therapy in patients with locally recurrent prostate cancer

    NASA Astrophysics Data System (ADS)

    Stripp, Diana C. H.; Mick, Rosemarie; Zhu, Timothy C.; Whittington, Richard; Smith, Debbie; Dimofte, Andreea; Finlay, Jarod C.; Miles, Jeremy; Busch, Theresa M.; Shin, Daniel; Kachur, Alex; Tochner, Zelig A.; Malkowicz, S. Bruce; Glatstein, Eli; Hahn, Stephen M.

    2004-06-01

    Therapeutic options for patients with locally recurrent prostate cancer after treatment with radiation therapy are limited. An ongoing Phase I trial of interstitial photodynamic therapy (PDT) with the photosensitizer motexafin lutetium (MLu) was initiated in year 2000 for men with locally recurrent prostate cancer. The primary objective of this trial is to determine the maximally tolerated dose of motexafin lutetium-mediated PDT. Twelve men with biopsy-proven recurrent prostate cancer and no evidence of distant metastatic disease have been enrolled. Pre-treatment evaluation included an MRI of the prostate, bone scan, laboratory studies, cystoscopy, and transrectal ultrasound. Treatment plans were generated based upon the ultrasound findings. PDT dose was escalated by increasing the motexafin lutetium dose, increasing the 732 nm light dose, and decreasing the drug-light interval. Motexafin lutetium doses ranged from 0.5 to 2 mg/kg administered IV 3, 6, or 24 hours prior to 732 nm light delivery. The light dose measured in real time with in situ spherical detectors was 25-100 J/cm2 for all patients. Light was delivered through optical fibers inserted through a transperineal brachytherapy template in the operating room and optical property measurements were made before and after light therapy. Prostate biopsies were obtained before and after light delivery for spectrofluorometric measurements of photosensitizer uptake. Twelve patients have completed protocol treatment on eight dose levels without dose-limiting toxicity. Grade I PDT-related genitourinary symptoms were observed. One patient had Grade II urinary urgency that was urinary catheter-related. No rectal or other GI PDT-related toxicities were observed. Measurements of motexafin lutetium in prostate tissue demonstrated the presence of photosensitizer at all dose levels. Conclusions: Motexafin lutetium-mediated PDT designed to treat comprehensively the entired prostate gland has been well-tolerated at the doses

  16. Half-life measurements of lutetium-176 using underground HPGe-detectors.

    PubMed

    Hult, Mikael; Vidmar, Tim; Rosengård, Ulf; Marissens, Gerd; Lutter, Guillaume; Sahin, Namik

    2014-05-01

    The half-life of (176)Lu was determined by measuring the (176)Lu activity in metallic lutetium foils. Three different HPGe-detectors located 225 m underground were employed for the study. Measurements using the sum-peak method were performed and resulted in an average massic activity of (52.61±0.36) Bq g(-1). The foils were of natural isotopic abundance so using the massic activity and the value of the natural isotopic abundance of (2.59±0.01)%, a half-life of (3.722±0.029)×10(10)a could be calculated.

  17. Syntheses and structures of mononuclear lutetium imido complexes with very short Lu-N bonds.

    PubMed

    Panda, Tarun K; Randoll, Sören; Hrib, Cristian G; Jones, Peter G; Bannenberg, Thomas; Tamm, Matthias

    2007-12-21

    The reaction of 1,3-bis(2,6-diisopropylphenyl)imidazolin-2-imine (ImDippNH) with trimethylsilylmethyllithium and anhydrous lutetium trichloride affords the imido complex [LuCl2(ImNDipp)(THF)3], which, on further reaction with dipotassium cyclooctatetraenide, K2(C8H8), leads to the half-sandwich cyclooctatetraenyl complex [(eta8-C8H8)Lu(ImNDipp)(THF)2]; both complexes contain very short Lu-N bond lengths, which are shorter than any previously reported Lu-N distances.

  18. Growth of epitaxial bismuth and gallium substituted lutetium iron garnet films by pulsed laser deposition

    SciTech Connect

    Leitenmeier, Stephan; Heinrich, Andreas; Lindner, Joerg K. N.; Stritzker, Bernd

    2006-04-15

    Epitaxial bismuth and gallium substituted lutetium iron garnet thin films have been grown on (100) oriented gadolinium gallium garnet Gd{sub 3}Ga{sub 5}O{sub 12} substrates by pulsed laser deposition. The films have been studied using x-ray diffraction, high resolution x-ray diffraction, Rutherford backscattering spectroscopy, transmission electron microscopy, and electron diffraction. We obtained smooth films with thicknesses between 0.3 and 1.0 {mu}m showing good crystalline quality and epitaxial growth.

  19. Lutetium alkyl and hydride complexes in a non-cyclopentadienyl coordination environment.

    PubMed

    Konkol, Marcin; Spaniol, Thomas P; Kondracka, Małgorzata; Okuda, Jun

    2007-09-28

    Lutetium alkyl complexes [Lu(L)(CH(2)SiMe(3))(THF)(n)], which contain a sulfur-linked bis(phenolato) ligand such as 2,2'-thiobis(6-tert-butyl-4-methylphenolate) (L=tbmp, 1) or 1,4-dithiabutanediyl-bis(6-tert-butyl-4-methylphenolate) (L=etbmp, 2), were isolated from the reaction of the lutetium tris(alkyl) complex [Lu(CH(2)SiMe(3))(3)(THF)(2)] with H(2)L. The monomeric structures of these complexes were confirmed by X-ray diffraction studies, showing distorted octahedral geometry around the metal centre. The reaction of [Lu(tbmp)(CH(2)SiMe(3))(THF)(2)] (1) with alcohols ROH (R=iPr, CHPh(2), CPh(3)) results in the formation of the corresponding alkoxide complexes [Lu(tbmp)(OR)(THF)(n)] (4-6). With PhSiH(3) hydride complexes [Lu(L)(mu-H)(THF)(n)](2) (L=tbmp, 7; etbmp, 8) have been prepared in moderate to good yields. They adopt a dimeric form in the solid state as revealed by the X-ray crystal structure of 7. The reactivity of the hydride complexes and their catalytic activity in the ring-opening polymerisation of L-lactide and the hydrosilylation of alkenes are also discussed.

  20. Atomic and electronic structures of lutetium oxide Lu{sub 2}O{sub 3}

    SciTech Connect

    Kaichev, V. V.; Asanova, T. I.; Erenburg, S. B.; Perevalov, T. V.; Shvets, V. A.; Gritsenko, V. A.

    2013-02-15

    The chemical composition, electronic structure, structure, and physical properties a lutetium oxide Lu{sub 2}O{sub 3} film are studied by X-ray photoelectron spectroscopy, ellipsometry, and X-ray absorption spectroscopy. The short-range order in Lu{sub 2}O{sub 3} is found to correspond to its cubic modification. The binding energies of the 1s and 2p levels of oxygen and the 4d{sub 5/2} and 4f{sub 7/2} levels of lutetium are 529.2, 5.0 and 7.4, 195.9 eV, respectively. The energy gap determined from the electron energy loss spectrum of the film is 5.9 eV. The electron energy loss spectra have two peaks at 17.4 and 22.0 eV, which can be attributed to the excitation of bulk plasma oscillations. The dispersion of the refractive index is measured by spectral ellipsometry. The refractive index is shown to increase from 1.82 at 1.5 eV to 2.18 at 5.0 eV, and the high-frequency permittivity of Lu{sub 2}O{sub 3} is 3.31.

  1. On the photoelectron velocity-map imaging of lutetium monoxide anion LuO{sup −}

    SciTech Connect

    Liu, Zhiling; Xie, Hua; Qin, Zhengbo; Cong, Ran; Wu, Xia; Tang, Zichao Fan, Hongjun; Li, Quanjiang

    2014-01-21

    We report a combined photoelectron velocity-map imaging spectroscopy and density functional theory investigation on lutetium monoxide anion. Transition between the X {sup 1}Σ{sup +} anion electronic ground state and the neutral X {sup 2}Σ{sup +} electronic ground state is observed. Vibrationally resolved spectra were obtained at four different photon energies, providing a wealth of spectroscopic information for the electronic ground states of the anionic lutetium monoxide and corresponding neutral species. Franck-Condon simulations of the ground-state transition are performed to assign vibrational structure in the spectra and to assist in identifying the observed spectral bands. The electronic ground state of LuO{sup −} is found to have a vibrational frequency of 743 ± 10 cm{sup −1} and an equilibrium bond length of 1.841 Å. The electron affinity of LuO is measured to be 1.624 ± 0.002 eV. The fundamental frequency of ground-state LuO is estimated to be 839 ± 10 cm{sup −1}.

  2. On the photoelectron velocity-map imaging of lutetium monoxide anion LuO(-).

    PubMed

    Liu, Zhiling; Xie, Hua; Li, Quanjiang; Qin, Zhengbo; Cong, Ran; Wu, Xia; Tang, Zichao; Fan, Hongjun

    2014-01-21

    We report a combined photoelectron velocity-map imaging spectroscopy and density functional theory investigation on lutetium monoxide anion. Transition between the X (1)Σ(+) anion electronic ground state and the neutral X (2)Σ(+) electronic ground state is observed. Vibrationally resolved spectra were obtained at four different photon energies, providing a wealth of spectroscopic information for the electronic ground states of the anionic lutetium monoxide and corresponding neutral species. Franck-Condon simulations of the ground-state transition are performed to assign vibrational structure in the spectra and to assist in identifying the observed spectral bands. The electronic ground state of LuO(-) is found to have a vibrational frequency of 743 ± 10 cm(-1) and an equilibrium bond length of 1.841 Å. The electron affinity of LuO is measured to be 1.624 ± 0.002 eV. The fundamental frequency of ground-state LuO is estimated to be 839 ± 10 cm(-1).

  3. Inclusion complexes of trivalent lutetium cations with an acidic derivative of per(3,6-anhydro)-alpha-cyclodextrin.

    PubMed

    Bonnet, Célia; Gadelle, Andrée; Pécaut, Jacques; Fries, Pascal H; Delangle, Pascale

    2005-02-07

    The cyclodextrin derivative (hexakis (2-O-carboxymethyl-3,6-anhydro)-alpha-cyclodextrin) forms mono- and bimetallic complexes with lutetium(III) in aqueous solution; the X-ray structure of the binuclear complex [Lu2(ACX)(H2O)2] is the first example of a lanthanide-cyclodextrin inclusion complex.

  4. 50 CFR 216.187 - Applications for Letters of Authorization.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Array Sensor System Low Frequency Active (SURTASS LFA sonar) Sonar § 216.187 Applications for Letters of... scheduled to begin conducting SURTASS LFA sonar operations or the previous Letter of Authorization...

  5. 50 CFR 216.187 - Applications for Letters of Authorization.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Array Sensor System Low Frequency Active (SURTASS LFA sonar) Sonar § 216.187 Applications for Letters of... scheduled to begin conducting SURTASS LFA sonar operations or the previous Letter of Authorization...

  6. Vacuum ultraviolet field emission lamp consisting of neodymium ion doped lutetium fluoride thin film as phosphor.

    PubMed

    Yanagihara, Masahiro; Tsuji, Takayuki; Yusop, Mohd Zamri; Tanemura, Masaki; Ono, Shingo; Nagami, Tomohito; Fukuda, Kentaro; Suyama, Toshihisa; Yokota, Yuui; Yanagida, Takayuki; Yoshikawa, Akira

    2014-01-01

    A vacuum ultraviolet (VUV) field emission lamp was developed by using a neodymium ion doped lutetium fluoride (Nd(3+) : LuF3) thin film as solid-state phosphor and carbon nanofiber field electron emitters. The thin film was synthesized by pulsed laser deposition and incorporated into the lamp. The cathodoluminescence spectra of the lamp showed multiple emission peaks at 180, 225, and 255 nm. These emission spectra were in good agreement with the spectra reported for the Nd(3+) : LuF3 crystal. Moreover, application of an acceleration voltage effectively increased the emission intensity. These results contribute to the performance enhancement of the lamp operating in the VUV region.

  7. Vacuum Ultraviolet Field Emission Lamp Consisting of Neodymium Ion Doped Lutetium Fluoride Thin Film as Phosphor

    PubMed Central

    Yanagihara, Masahiro; Tsuji, Takayuki; Yusop, Mohd Zamri; Tanemura, Masaki; Nagami, Tomohito; Fukuda, Kentaro; Suyama, Toshihisa; Yokota, Yuui; Yanagida, Takayuki; Yoshikawa, Akira

    2014-01-01

    A vacuum ultraviolet (VUV) field emission lamp was developed by using a neodymium ion doped lutetium fluoride (Nd3+ : LuF3) thin film as solid-state phosphor and carbon nanofiber field electron emitters. The thin film was synthesized by pulsed laser deposition and incorporated into the lamp. The cathodoluminescence spectra of the lamp showed multiple emission peaks at 180, 225, and 255 nm. These emission spectra were in good agreement with the spectra reported for the Nd3+ : LuF3 crystal. Moreover, application of an acceleration voltage effectively increased the emission intensity. These results contribute to the performance enhancement of the lamp operating in the VUV region. PMID:25302320

  8. Photoemission spectroscopy study of the lanthanum lutetium oxide/silicon interface

    SciTech Connect

    Nichau, A.; Schnee, M.; Schubert, J.; Bernardy, P.; Hollaender, B.; Buca, D.; Mantl, S.; Besmehn, A.; Breuer, U.; Rubio-Zuazo, J.; Castro, G. R.; Muecklich, A.; Borany, J. von

    2013-04-21

    Rare earth oxides are promising candidates for future integration into nano-electronics. A key property of these oxides is their ability to form silicates in order to replace the interfacial layer in Si-based complementary metal-oxide field effect transistors. In this work a detailed study of lanthanum lutetium oxide based gate stacks is presented. Special attention is given to the silicate formation at temperatures typical for CMOS processing. The experimental analysis is based on hard x-ray photoemission spectroscopy complemented by standard laboratory experiments as Rutherford backscattering spectrometry and high-resolution transmission electron microscopy. Homogenously distributed La silicate and Lu silicate at the Si interface are proven to form already during gate oxide deposition. During the thermal treatment Si atoms diffuse through the oxide layer towards the TiN metal gate. This mechanism is identified to be promoted via Lu-O bonds, whereby the diffusion of La was found to be less important.

  9. Photoelectric conversion and electrochromic properties of lutetium tetrakis(tert-butyl)bisphthalocyaninate

    SciTech Connect

    Hu, Andrew Teh; Hu Tenyi; Liu Lungchang

    2003-12-10

    Both photoelectric and electrochromic effects on lutetium tetrakis(tert-butyl)bisphthalocyaninate (Lu(TBPc){sub 2}) have been carried out in this study. Lu(TBPc){sub 2} is known for its electrochromic performance, but its photoelectric effect has not mentioned in the literature. The electrochromic properties of Lu(TBPc){sub 2} have been measured by cyclic voltammetry (CV) and UV-Vis spectrometer at the same time. It takes less than 1.5 s for the color to change from red to green under 0.9 V. Its cycle life is at least over 500 times. Furthermore, we also investigate its photoelectric conversion properties. Its photoelectric cell exhibits a positive photo-electricity conversion effect with a short-circuit photocurrent (46.4 {mu}A/cm{sup 2}) under illumination of white light (1.201 mW/cm{sup 2})

  10. A new coprecipitation methodology with lutetium hydroxide for preconcentration of heavy metal ions in herbal plant samples.

    PubMed

    Soylak, Mustafa; Murat, Ipek

    2014-01-01

    A new coprecipitation methodology that used lutetium hydroxide as a precipitant for Cu(II), Pb(II), Mn(II), Co(II), Cd(II), Fe(III), and Ni(II) ions in herbal plant and water samples for analysis by atomic absorption spectrometry has been investigated. The parameters such as pH, amount of lutetium, and volume of aqueous sample were optimized for the recovery of these seven metals. The effects of concomitant ions on the separation-preconcentration of analytes were also checked. The validation of the procedure was checked with addition recovery tests and analysis of Standard Reference Material 1570a-Trace Elements in Spinach Leaves and TMDA-70 fortified lake water Certified Reference Material. The LODs for analyte ions were in the range of 1.7-7.2 microg/L. The application of the present procedure was successfully performed for the analysis of analyte contents of herbal plant samples from Turkey.

  11. Rare-earth antisites in lutetium aluminum garnets: Influence on lattice parameter and Ce3+ multicenter structure

    NASA Astrophysics Data System (ADS)

    Przybylińska, H.; Wittlin, A.; Ma, Chong-Geng; Brik, M. G.; Kamińska, A.; Sybilski, P.; Zorenko, Yu.; Nikl, M.; Gorbenko, V.; Fedorov, A.; Kučera, M.; Suchocki, A.

    2014-07-01

    Low temperature, infrared transmission spectra of lutetium aluminum garnet (LuAG) bulk crystals and epitaxial layers doped with Ce are presented. In the region of intra-configurational 4f-4f transitions the spectra of the bulk LuAG crystal exhibit the signatures of several different Ce3+ related centers. Apart from the dominant center, associated with Ce substituting lutetium, at least six other centers are found, some of them attributed to so-called antisite locations of rare-earth ions in the garnet host, i.e., ions in the Al positions. X-ray diffraction data prove lattice expansion of bulk LuAG crystals due presence of rare-earth antisites.

  12. Features of the spectral dependences of transmittance of organic semiconductors based on tert-butyl substituted lutetium phthalocyanine molecules

    SciTech Connect

    Belogorokhov, I. A.; Tikhonov, E. V.; Dronov, M. A.; Belogorokhova, L. I.; Ryabchikov, Yu. V.; Tomilova, L. G.; Khokhlov, D. R.

    2011-11-15

    Vibronic properties of organic semiconductors based on tert-butyl substituted phthalocyanine lutetium diphthalocyanine molecules are studied by IR and Raman spectroscopy. It is shown that substitution of several carbon atoms in initial phthalocyanine (Pc) ligands with {sup 13}C isotope atoms causes a spectral shift in the main absorption lines attributed to benzene, isoindol, and peripheral C-H groups. A comparison of spectral characteristics showed that the shift can vary from 3 to 1 cm{sup -1}.

  13. 27 CFR 17.187 - Discontinuance of business.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Discontinuance of business... PRODUCTS Miscellaneous Provisions § 17.187 Discontinuance of business. The manufacturer shall notify TTB when business is to be discontinued. Upon discontinuance of business, a manufacturer's entire stock...

  14. 187. Photocopy of drawing, Twin Falls Canal Company, date unknown. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    187. Photocopy of drawing, Twin Falls Canal Company, date unknown. TOPOGRAPHICAL MAP OF MILNER DAM LOCATION, TWIN FALLS COUNTY, MILNER, IDAHO; BLUEPRINT MAP. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  15. 27 CFR 19.187 - Adoption of formulas.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Adoption of formulas. 19... After Original Qualification § 19.187 Adoption of formulas. (a) Forms 5110.38. The adoption by a... the appropriate TTB officer. The application shall list the formulas for adoption by (1)...

  16. Copycat Fever: California's Proposition 187 Epidemic Spreads to Other States.

    ERIC Educational Resources Information Center

    Quiroga, Angelica

    1995-01-01

    Although blocked by a preliminary injunction, Proposition 187, also known as the Save Our State Initiative, would ban nonemergency health care, schooling, and other social services for illegal immigrants. Since its passage by the citizens of California in 1994, several states, such as Arizona, Washington, Oregon, and Florida, have begun to…

  17. 10 CFR 26.187 - Substance abuse expert.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Determining Fitness-for-Duty Policy Violations and Determining Fitness § 26.187 Substance abuse expert. (a) Implementation. By March 31, 2010, any SAEs on whom licensees and other entities rely to make determinations of fitness under this part shall meet...

  18. 10 CFR 26.187 - Substance abuse expert.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Determining Fitness-for-Duty Policy Violations and Determining Fitness § 26.187 Substance abuse expert. (a) Implementation. By March 31, 2010, any SAEs on whom licensees and other entities rely to make determinations of fitness under this part shall meet...

  19. 10 CFR 26.187 - Substance abuse expert.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Determining Fitness-for-Duty Policy Violations and Determining Fitness § 26.187 Substance abuse expert. (a) Implementation. By March 31, 2010, any SAEs on whom licensees and other entities rely to make determinations of fitness under this part shall meet...

  20. 10 CFR 26.187 - Substance abuse expert.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Determining Fitness-for-Duty Policy Violations and Determining Fitness § 26.187 Substance abuse expert. (a) Implementation. By March 31, 2010, any SAEs on whom licensees and other entities rely to make determinations of fitness under this part shall meet...

  1. 10 CFR 26.187 - Substance abuse expert.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Determining Fitness-for-Duty Policy Violations and Determining Fitness § 26.187 Substance abuse expert. (a) Implementation. By March 31, 2010, any SAEs on whom licensees and other entities rely to make determinations of fitness under this part shall meet...

  2. 27 CFR 17.187 - Discontinuance of business.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2012-04-01 2012-04-01 false Discontinuance of business... PRODUCTS Miscellaneous Provisions § 17.187 Discontinuance of business. The manufacturer shall notify TTB when business is to be discontinued. Upon discontinuance of business, a manufacturer's entire stock...

  3. 19 CFR 18.7 - Lading for exportation, verification of.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Lading for exportation, verification of. 18.7... for exportation, verification of. (a) Promptly, but no more than 2 working days, after arrival of any portion of the in-bond shipment at the port of exportation, the delivering carrier shall surrender the...

  4. 187. Photocopy of drawing (1975 demolition drawing by the Ralph ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    187. Photocopy of drawing (1975 demolition drawing by the Ralph M. Parsons Company) DEMOLITION AND REMOVAL PLANS FOR MST STATIONS 3 AND 12, SHEET D-4 - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 East, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

  5. A Study of the Physical and Mechanical Properties of Lutetium Compared with Those of Transition Metals: A Data Mining Approach

    NASA Astrophysics Data System (ADS)

    Settouti, Nadera; Aourag, Hafid

    2015-01-01

    In this article, we study the physical and mechanical properties of lutetium, which will be compared with the elements of the third-row transition metals (Cs, Ba, Hf, Ta, W, Re, Os, Ir, Pt, Au, Tl, Pb, and Bi). Data mining is an ideal approach for analyzing the information and exploring the hidden knowledge among the data. The purpose of the data mining scheme is to identify and classify the effects of the relationships existing between properties. The results of the investigation are presented by means of multivariate modeling methods, such as the principal component analysis and the partial least squares regression to discover the implicit, yet meaningful, relationship between the elements of the data set, and to locate correlations between the properties of the materials. In this study, we present a data mining approach to discover such unusual correlations between properties of the elements. When comparing the properties of the transition metals with those of lutetium, our results show that lutetium shares many properties and similarities with the transition metals of the sixth row in the periodic table and can be well described as a transition metal.

  6. Physical properties of zircon and scheelite lutetium orthovanadate: Experiment and first-principles calculation

    SciTech Connect

    Huang, Zuocai; Zhang, Lei; Pan, Wei

    2013-09-15

    Pure zircon and scheelite LuVO{sub 4} were prepared by solid state reaction and high-pressure route, respectively. Structure, elastic constants, lattice dynamics and thermodynamics of LuVO{sub 4} polymorphs were studied by experiments and first principles calculation. Calculations here are in good agreement with the experimental results. The phonon dispersions of LuVO{sub 4} polymorphs were studied by the linear response method. The calculated phonon dispersions show that zircon and scheelite LuVO{sub 4} phases are dynamically stable. Raman-active frequencies were measured and assigned to different modes according to the calculations. The internal frequencies shift downward after phase transition from zircon to scheelite. Born effective charge tensors elements for both phases are analyzed. The finite temperature thermodynamic properties of LuVO{sub 4} polymorphs were calculated from the obtained phonon density of states by quasi-harmonic approach. - Graphical abstract: Lutetium orthovanadate polymorphs were synthesized by SSR and HP methods and their physical and chemical properties, including lattice dynamical properties, were determined by DFT calculations and experiments. Display Omitted - Highlights: • Pure zircon and scheelite LuVO{sub 4} polymorphs were synthesized by solid state reaction and high-pressure route. • Chemical and physical properties of LuVO4 polymorphs were studied by experiments and first principles calculation. • Raman-active frequencies were measured and assigned to different modes according to the calculations. • Lattice dynamics of polymorphs were discussed in details.

  7. Lutetium speciation and toxicity in a microbial bioassay: testing the free-ion model for lanthanides.

    PubMed

    Weltje, Lennart; Verhoof, Lars R C W; Verweij, Wilko; Hamers, Timo

    2004-12-15

    The validity of the free-ion model (FIM) for the element lutetium (Lu), a member of the lanthanides, was assessed in experiments with the bacterium Vibrio fischeri. The FIM is mainly based on divalent metals and synthetic ligands and has not yet been validated for the trivalent lanthanides. The bioluminescence response of V. fischeri was studied at different Lu concentrations in the presence and absence of natural and synthetic organic ligands [citrate, malate, oxalate, acetate, ethylenediaminetetraacetate (EDTA), and nitrilotriacetate (NTA)]. All ligands were tested separately to ensure that their concentrations would not cause adverse effects themselves. Free Lu3+ concentrations were calculated with a speciation program, after extension of its database with the relevant Lu equilibria. The results confirmed the FIM for Lu: that is, in contrast to total dissolved Lu concentrations, free Lu3+ concentrations had an apparent relationship with the response of V. fischeri. However, a contribution of minor inorganic Lu complexes cannot be ruled out. In the presence of malate and oxalate, the EC50 for Lu3+ decreased faster in time than for the other ligands, indicating lower elimination rates. With an EC50 of 1.57 microM, Lu3+ is more toxic than La3+, Cd2+, or Zn2+ and approximately equally as toxic as Cu2+. Although the pH increased slightly during the experiments, it was shown that the influence of pH on Lu speciation was limited.

  8. Volatile organic compounds sensing properties of tetrakis(alkylthio)-substituted lutetium(III) bisphthalocyanines thin films.

    PubMed

    Kilinç, Necmettin; Atilla, Devrim; Gürek, Ayşe Gül; Oztürk, Zafer Ziya; Ahsen, Vefa

    2009-11-15

    The effect of volatile organic compounds (VOCs) such as acetone, methanol, ethanol, chloroform, carbon tetrachloride, dichloromethane, and hexane on electrical conductivity of thin films of bis[tetrakis(alkylthio)phthalocyaninato]lutetium(III) double decker complexes [(C(n)H(2n+1)S)(4)Pc](2)Lu(III) was investigated. The [(C(n)H(2n+1)S)(4)Pc](2)Lu(III) molecules substituted with different alkylthia chains (n=6, 8, 10, 12, and 16) were coated on interdigital transducers using a jet spray technique. A change (increase or decrease) in the conductivity of the [(C(n)H(2n+1)S)(4)Pc](2)Lu(III) films was observed depending on the concentration of the VOCs, which was ranging from 500 to 5000 ppm. The decrease in the conductivity of the sensors for the dissolvent of the compounds (chloroform, carbon tetrachloride, dichloromethane and hexane) could be related to swelling of the films. On the other hand, the increase in the conductivity of the sensors for the other VOCs (acetone, methanol and ethanol) could be resulted from that the VOCs act as electron donors and/or acceptors in the films. A linear relationship between the sensor response and concentration of the VOC vapors is obtained. The sensitivities of the [(C(n)H(2n+1)S)(4)Pc](2)Lu(III) films were in the range of 2.10(-4)-3.10(-3)%/ppm.

  9. Lutetium 177-DOTA-TATE therapy for esthesioneuroblastoma: A case report.

    PubMed

    Sabongi, Juliano Guerra; Gonçalves, Mônica Carboni Pereira; Alves, Cira Danielle Casado; Alves, João; Scapulatempo-Neto, Cristovam; Moriguchi, Sonia Marta

    2016-11-01

    Esthesioneuroblastoma (ENB), also known as olfactory neuroblastoma, is a rare malignant tumor that accounts for 3% of all tumors of the nasal cavity. The incidence of ENB is 0.4 cases per million in the general population, and the most common symptoms are nasal obstruction and epistaxis. Previous studies have indicated the presence of somatostatin receptors in this tumor type. Common treatment strategies for ENB include resection and adjuvant radiotherapy and/or chemotherapy (combined treatment); however, the rate of recurrence is high. Treatment of neuroendocrine tumors using radionuclides bound to somatostatin analogues is well established in clinical practice. However, a standard and effective therapeutic approach has not been reported for ENB. The current study described the case of a 74-year-old female with numerous recurrences of ENB following multiple treatments and without possibility of resection. The patient was treated with the radiolabeled-somatostatin analogue, (177)Lutetium-DOTA-octreotate ((177)Lu-DOTA-TATE), which successfully controlled the disease. This suggests that (177)Lu-DOTA-TATE is a potential treatment for ENB and may represent an effective alternative and novel therapeutic strategy for this disease.

  10. The melting behavior of lutetium aluminum perovskite LuAlO3

    NASA Astrophysics Data System (ADS)

    Klimm, Detlef

    2010-02-01

    DTA measurements with mixtures of aluminum oxide and lutetium oxide around the 1:1 perovskite composition were performed up to 1970C. A peak with onset 1901C was due to the melting of the eutectic Lu4Al2O9 (monoclinic phase) and LuAlO3 (perovskite). Neither peritectic melting of the perovskite nor its decomposition in the solid phase could be resolved experimentally. The maximum of the eutectic peak size is near x=0.44, on the Lu-rich side of the perovskite, which is consistent with the conclusion that LuAlO3 melts peritectically at ca. 1907C as proposed by Wu, Pelton, J. Alloys Compd. 179 (1992) 259. Thermodynamic equilibrium calculation reveals that under strongly reducing conditions (oxygen partial pressure <10-13 bar) aluminum(III) oxide can be reduced to suboxides or even Al metal. It is shown that under such conditions a new phase field with liquid Al can appear.

  11. Lutetium 177-DOTA-TATE therapy for esthesioneuroblastoma: A case report

    PubMed Central

    Sabongi, Juliano Guerra; Gonçalves, Mônica Carboni Pereira; Alves, Cira Danielle Casado; Alves, João; Scapulatempo-Neto, Cristovam; Moriguchi, Sonia Marta

    2016-01-01

    Esthesioneuroblastoma (ENB), also known as olfactory neuroblastoma, is a rare malignant tumor that accounts for 3% of all tumors of the nasal cavity. The incidence of ENB is 0.4 cases per million in the general population, and the most common symptoms are nasal obstruction and epistaxis. Previous studies have indicated the presence of somatostatin receptors in this tumor type. Common treatment strategies for ENB include resection and adjuvant radiotherapy and/or chemotherapy (combined treatment); however, the rate of recurrence is high. Treatment of neuroendocrine tumors using radionuclides bound to somatostatin analogues is well established in clinical practice. However, a standard and effective therapeutic approach has not been reported for ENB. The current study described the case of a 74-year-old female with numerous recurrences of ENB following multiple treatments and without possibility of resection. The patient was treated with the radiolabeled-somatostatin analogue, 177Lutetium-DOTA-octreotate (177Lu-DOTA-TATE), which successfully controlled the disease. This suggests that 177Lu-DOTA-TATE is a potential treatment for ENB and may represent an effective alternative and novel therapeutic strategy for this disease. PMID:27882120

  12. SIMS chemical and isotopic analysis of impact features from LDEF experiments AO187-1 and AO187-2

    NASA Technical Reports Server (NTRS)

    Stadermann, Frank J.; Amari, Sachiko; Foote, John; Swan, Pat; Walker, Robert M.; Zinner, Ernst

    1995-01-01

    Previous secondary ion mass spectrometry (SIMS) studies of extended impact features from LDEF capture cell experiment AO187-2 showed that it is possible to distinguish natural and man-made particle impacts based on the chemical composition of projectile residues. The same measurement technique has now been applied to specially prepared gold target impacts from experiment AO187-1 in order to identify the origins of projectiles that left deposits too thin to be analyzed by conventional energy-dispersive x-ray (EDX) spectroscopy. The results indicate that SIMS may be the method of choice for the analysis of impact deposits on a variety of sample surfaces. SIMS was also used to determine the isotopic compositions of impact residues from several natural projectiles. Within the precision of the measurements all analyzed residues show isotopically normal compositions.

  13. 40 CFR 761.187 - Reporting importers and by persons generating PCBs in excluded manufacturing processes.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... generating PCBs in excluded manufacturing processes. 761.187 Section 761.187 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT POLYCHLORINATED BIPHENYLS (PCBs... Reporting importers and by persons generating PCBs in excluded manufacturing processes. In addition...

  14. Parameters for the RM1 Quantum Chemical Calculation of Complexes of the Trications of Thulium, Ytterbium and Lutetium.

    PubMed

    Filho, Manoel A M; Dutra, José Diogo L; Rocha, Gerd B; Simas, Alfredo M; Freire, Ricardo O

    2016-01-01

    The RM1 quantum chemical model for the calculation of complexes of Tm(III), Yb(III) and Lu(III) is advanced. Subsequently, we tested the models by fully optimizing the geometries of 126 complexes. We then compared the optimized structures with known crystallographic ones from the Cambridge Structural Database. Results indicate that, for thulium complexes, the accuracy in terms of the distances between the lanthanide ion and its directly coordinated atoms is about 2%. Corresponding results for ytterbium and lutetium are both 3%, levels of accuracy useful for the design of lanthanide complexes, targeting their countless applications.

  15. Parameters for the RM1 Quantum Chemical Calculation of Complexes of the Trications of Thulium, Ytterbium and Lutetium

    PubMed Central

    Filho, Manoel A. M.; Dutra, José Diogo L.; Rocha, Gerd B.; Simas, Alfredo M.

    2016-01-01

    The RM1 quantum chemical model for the calculation of complexes of Tm(III), Yb(III) and Lu(III) is advanced. Subsequently, we tested the models by fully optimizing the geometries of 126 complexes. We then compared the optimized structures with known crystallographic ones from the Cambridge Structural Database. Results indicate that, for thulium complexes, the accuracy in terms of the distances between the lanthanide ion and its directly coordinated atoms is about 2%. Corresponding results for ytterbium and lutetium are both 3%, levels of accuracy useful for the design of lanthanide complexes, targeting their countless applications. PMID:27223475

  16. Structural and electrochemical properties of lutetium bis-octachloro-phthalocyaninate nanostructured films. Application as voltammetric sensors.

    PubMed

    Alessio, P; Apetrei, C; Rubira, R J G; Constantino, C J L; Medina-Plazal, C; De Saja, J A; Rodríguez-Méndez, M L

    2014-09-01

    Thin films of the bis[2,3,9,10,16,17,23,24-octachlorophthalocyaninate] lutetium(III) complex (LuPc2Cl32) have been prepared by the Langmuir-Blodgett and the Langmuir-Schaefer (LS) techniques. The influence of the chlorine substituents in the structure of the films and in their spectroscopic, electrochemical and sensing properties has been evaluated. The π-A isotherms exhibit a monolayer stability greater than the observed in the unsubstituted analogue (LuPc2), being easily transferred to solid substrates, also in contrast to LuPc2. The LB and LS films present a linear growth forming stratified layers, monitored by UV-VIS absorption spectroscopy. The latter also revealed the presence of LuPc2Cl32 in the form of monomers and aggregates in both films. The FTIR data showed that the LuPc2Cl32 molecules present a non-preferential arrangement in both films. Monolayers of LB and LS were deposited onto 6 nm Ag island films to record surface-enhanced resonance Raman scattering (SERRS), leading to enhancement factors close to 2 x 10(3). Finally, LB and LS films deposited onto ITO glass have been successfully used as voltammetric sensors for the detection of catechol. The improved electroactivity of the LB and LS films has been confirmed by the reduction of the overpotential of the oxidation of catechol. The enhancement of the electrocatalytic effect observed in LB and LS films is the result of the nanostructured arrangement of the surface which increases the number of active sites. The sensors show a limit of detection in the range of 10(-5) mol/L.

  17. Lutetium(III)-dependent self-assembly study of ciliate Euplotes octocarinatus centrin.

    PubMed

    Duan, Lian; Zhao, Ya-Qin; Wang, Zhi-Jun; Li, Guo-Ting; Liang, Ai-Hua; Yang, Bin-Sheng

    2008-02-01

    Ciliate Euplotes octocarinatus centrin (EoCen) is a member of the EF-hand superfamily of calcium-binding proteins, which often associated with the centrosomes and basal bodies. To explore the possible structural role of EoCen, we initiated a physicochemical study of the self-assembly properties of the purified protein in vitro. The native PAGE results indicate that only the integral protein shows multimers in the presence of Lu(3+). The dependence of Lu(3+) induced self-assembly of EoCen on various chemical and physical factors, including temperature, protein concentration, ionic strength and pH, was characterized using resonance light scattering (RLS). Control experiments with different metal ions suggest that Ca(2+) and Lu(3+) bindings to the N-terminal domain of EoCen are all positive to the self-assembly of the protein, and Lu(3+) exhibits the stronger effect, however, Mg(2+) alone cannot take the same effect. The experiments of 2-ptoluidinylnaphthalene-6-sulfonate (TNS) binding and ionic strength demonstrate that the lutetium(III)-dependent self-assembly is closely related to the exposure of hydrophobic cavity. Control experiment on pH value with EoCen and the fragments of it, N-terminal domain of EoCen (N-EoCen), indicates that the electrostatic effect is of small tendency to be served as the main driving force in the self-assembly of EoCen. The specific oligomerization form of the protein was exhibited by cross-linking experiment.

  18. Motexafin lutetium-photodynamic therapy of prostate cancer: Short and long term effects on PSA

    PubMed Central

    Patel, Hiral; Mick, Rosemarie; Finlay, Jarod; Zhu, Timothy C.; Rickter, Elizabeth; Cengel, Keith A.; Malkowicz, S. Bruce; Hahn, Stephen M.; Busch, Theresa M.

    2009-01-01

    Purpose: The time course of serum PSA response to photodynamic therapy (PDT) of prostate cancer was measured. Experimental Design: Seventeen patients were treated in a Phase I trial of motexafin lutetium-PDT. PDT dose was calculated in each patient as the product of the ex vivo-measured pre-PDT photosensitizer level and the in situ-measured light dose. Serum PSA level was measured within two months prior to PDT (baseline), and at day 1; weeks 1-3; months 1, 2 and 3; months 4-6 and months 7-11 after PDT. Results: At 24h after PDT, serum PSA increased by 98±36% (mean ± SE) relative to baseline levels (p=0.007). When patients were dichotomized based on median PDT dose, those who received high PDT dose demonstrated a 119±52% increase in PSA compared to a 54±27% increase in patients treated at low PDT dose. Patients treated with high vs. low PDT dose demonstrated a median biochemical delay of 82 vs. 43 days (p=0.024), with biochemical delay defined as the length of time between PDT and a nonreversible increase in PSA to a value ≥baseline. Conclusions: Results show PDT to induce large, transient increases in serum PSA levels. Patients who experienced high PDT dose demonstrated greater short-term increase in PSA and a significantly more durable PSA response (biochemical delay). These data strongly promote the need for individualized delivery of PDT dose and assessment of treatment effect in PDT of prostate cancer. Information gained from such patient-specific measurements could facilitate the introduction of multiple PDT sessions in patients who would benefit. PMID:18676760

  19. Investigation of high pressure phase transition and electronic properties of Lutetium Nitride

    NASA Astrophysics Data System (ADS)

    Singh, Sanjay Kumar; Verma, U. P.

    2015-09-01

    In the present manuscript we have investigated the structural, electronic and phase transition properties of the heaviest lanthanide lutetium nitride (LuN) compound using an ab initio calculations based on the density functional theory with Perdrew, Burke and Ernzerhof generalized gradient approximation (PBE-GGA) and Engel-Vosko(EV)-GGA as implemented in WIEN2k code. The basic ground state properties viz., lattice constants (a), bulk modulus (B0) and its pressure derivative (B0’) and total energy (E0) are calculated. The calculated values of lattice constant is 4.76 Å which is in good agreement with experimental value a= 4.76 A and other theoretical value. The relative stabilities of LuN at high pressures in the NaCl (B1), CsCl (B2), zinc blende (B3) and body centred tetragonal (BCT) structures are analysed. At compressed volumes, this compound is found to favour the CsCl phase rather the body centred tetragonal phase and zinc blende as observed in other lanthanum pnictides, which has been predicted by the total energy minimization. Under compression LuN undergoes a transition from NaCl to CsCl type structure at around 250.81 GPa with a volume collapse of 3.75%. To see the effect of functional we have also computed the band structure in B1 and B2 structure. Obtained result on band structure shows that LuN are semimetal by GGA while depicts semiconducting behaviour by EV-GGA. It shows metallic nature in B2 phase.

  20. 40 CFR 18.7 - Selection and appointment of Environmental Protection Research Fellows.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Environmental Protection Research Fellows. 18.7 Section 18.7 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL ENVIRONMENTAL PROTECTION RESEARCH FELLOWSHIPS AND SPECIAL RESEARCH CONSULTANTS FOR ENVIRONMENTAL PROTECTION § 18.7 Selection and appointment of Environmental Protection Research Fellows.......

  1. 40 CFR 18.7 - Selection and appointment of Environmental Protection Research Fellows.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Environmental Protection Research Fellows. 18.7 Section 18.7 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL ENVIRONMENTAL PROTECTION RESEARCH FELLOWSHIPS AND SPECIAL RESEARCH CONSULTANTS FOR ENVIRONMENTAL PROTECTION § 18.7 Selection and appointment of Environmental Protection Research Fellows.......

  2. 40 CFR 18.7 - Selection and appointment of Environmental Protection Research Fellows.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Environmental Protection Research Fellows. 18.7 Section 18.7 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL ENVIRONMENTAL PROTECTION RESEARCH FELLOWSHIPS AND SPECIAL RESEARCH CONSULTANTS FOR ENVIRONMENTAL PROTECTION § 18.7 Selection and appointment of Environmental Protection Research Fellows.......

  3. 40 CFR 18.7 - Selection and appointment of Environmental Protection Research Fellows.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Environmental Protection Research Fellows. 18.7 Section 18.7 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL ENVIRONMENTAL PROTECTION RESEARCH FELLOWSHIPS AND SPECIAL RESEARCH CONSULTANTS FOR ENVIRONMENTAL PROTECTION § 18.7 Selection and appointment of Environmental Protection Research Fellows.......

  4. 40 CFR 18.7 - Selection and appointment of Environmental Protection Research Fellows.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Environmental Protection Research Fellows. 18.7 Section 18.7 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL ENVIRONMENTAL PROTECTION RESEARCH FELLOWSHIPS AND SPECIAL RESEARCH CONSULTANTS FOR ENVIRONMENTAL PROTECTION § 18.7 Selection and appointment of Environmental Protection Research Fellows.......

  5. The message of 187: facing up to illegal immigration.

    PubMed

    Schuck, P H

    1995-01-01

    The author makes the case that the adoption of Proposition 187, the anti-illegal immigrant initiative, in California in 1994 was "an expression of public frustration with a government and civil society that seem out of touch and out of control, and with external convulsions that our borders can no longer contain." He suggests that the general public is increasingly concerned about the services provided to illegal aliens and their costs, and that responsible leadership should admit that illegal immigration, even at current levels, is not an unmitigated evil, and be prepared to set and enforce immigration limits.

  6. 187Re-187Os systematics, highly siderophile element, S-Se-Te abundances in the components of unequilibrated L chondrites

    NASA Astrophysics Data System (ADS)

    Kadlag, Yogita; Becker, Harry

    2016-01-01

    The 187Re-187Os systematics, abundances of highly siderophile elements (HSE: Re, platinum group elements and Au), Te, Se and S as well as major and minor elements were determined in separated components of two unequilibrated L chondrites QUE 97008 (L3.05) and Ceniceros (L3.7). The 187Re-187Os systematics are disturbed in the components of both meteorites, most likely due to open system behavior of Re during terrestrial weathering of QUE 97008 and alteration on the L chondrite parent body as indicated by an internal errorchron generated for components of Ceniceros. The HSE abundance patterns suggest that the bulk rock abundances were mainly controlled by two different end members. Non-magnetic fractions display lower Re/Os and HSE/Ir than CI chondrites. Chondrules, metal-troilite spherules and fine magnetic fractions, are depleted in refractory HSE and show higher Rh/Ir, Pd/Ir and Au/Ir than in CI chondrites. The different HSE compositions indicate the presence of unequilibrated alloys and loss of refractory HSE-rich carrier phases from the precursors of some L chondrite components. Gold is decoupled from other HSE in magnetic fractions and shows chalcophile affinities with a grain size dependent variation similar to S and Se, presumably inherited from preaccretionary processes. Tellurium is depleted in all components compared to other analysed siderophile elements, and its abundance was most likely controlled by fractional condensation and different geochemical affinities. The volatility dependent depletion of Te requires different physical and chemical conditions than typical for the canonical condensation sequence as represented by carbonaceous chondrites. Tellurium also shows variable geochemical behavior, siderophile in Ceniceros, predominantly chalcophile in QUE 97008. These differences may have been inherited from element partitioning during chondrule formation. Selenium and S on the other hand are almost unfractionated from each other and only show

  7. Piano-Stool Lutetium Amido and Imido Compounds Supported by a Constrained Bis(oxazoline)cyclopentadienyl Ligand.

    PubMed

    Lampland, Nicole L; Zhu, Jing; Hovey, Megan; Jana, Barun; Ellern, Arkady; Sadow, Aaron D

    2015-07-20

    {Bo(M)Cp(tet)}Lu(CH2Ph)2 (1; Bo(M)Cp(tet) = MeC(Ox(Me2))2C5Me4; Ox(Me2) = 4,4-dimethyl-2-oxazoline) was prepared in 95% yield from the reaction of Bo(M)Cp(tet)H and Lu(CH2Ph)3THF3. Compound 1 reacts with 1 or 2 equiv of H2NCH2R (R = C6H5, 1-C10H7) to give the corresponding imido complexes [{Bo(M)Cp(tet)}LuNCH2R]2 (R = C6H5 (2a), 1-C10H7 (2b)) or amido complexes {Bo(M)Cp(tet)}Lu(NHCH2R)2 (R = C6H5 (3a), 1-C10H7 (3b)). Once isolated, the imido species are insoluble in nonprotic organic solvents. Crystallographic characterization reveals dimeric [{Bo(M)Cp(tet)}LuNCH2(1-C10H7)]2 in the solid state. The reaction of 1 and NH3B(C6F5)3 affords crystallographically characterized {Bo(M)Cp(tet)}Lu{NHB(C6F5)2}C6F5. This species is proposed to form via a transient lutetium imido, which undergoes C6F5 migration to the lutetium center.

  8. High-phasing-power lanthanide derivatives: taking advantage of ytterbium and lutetium for optimized anomalous diffraction experiments using synchrotron radiation.

    PubMed

    Girard, E; Anelli, P L; Vicat, J; Kahn, R

    2003-10-01

    Ytterbium and lutetium are well suited for optimized anomalous diffraction experiments using synchrotron radiation. Therefore, two lanthanide complexes Yb-HPDO3A and Lu-HPDO3A have been produced that are similar to the Gd-HPDO3A complex already known to give good derivative crystals. Derivative crystals of hen egg-white lysozyme were obtained by co-crystallization using 100 mM solutions of each lanthanide complex. De novo phasing has been carried out using single-wavelength anomalous diffraction on data sets collected on each derivative crystal at the L(III) absorption edge of the corresponding lanthanide (ff" = 28 e(-)). A third data set was collected on a Lu-HPDO3A derivative crystal at the Se K absorption edge with f"(Lu) = 10 e(-). The structures were refined and compared with the known structure of the Gd-HPDO3A lysozyme derivative. The quality of the experimental electron-density maps allows easy model building. With L(III) absorption edges at shorter wavelengths than the gadolinium absorption edge, lutetium and ytterbium, when chelated by a ligand such as HPDO3A, form lanthanide complexes that are especially interesting for synchrotron-radiation experiments in structural biology.

  9. Anti-biofouling polymer-decorated lutetium-based nanoparticulate contrast agents for in vivo high-resolution trimodal imaging.

    PubMed

    Liu, Zhen; Dong, Kai; Liu, Jianhua; Han, Xueli; Ren, Jinsong; Qu, Xiaogang

    2014-06-25

    Nanomaterials have gained considerable attention and interest in the development of novel and high-resolution contrast agents for medical diagnosis and prognosis in clinic. A classical urea-based homogeneous precipitation route that combines the merits of in situ thermal decomposition and surface modification is introduced to construct polyethylene glycol molecule (PEG)-decorated hybrid lutetium oxide nanoparticles (PEG-UCNPs). By utilizing the admirable optical and magnetic properties of the yielded PEG-UCNPs, in vivo up-conversion luminescence and T1 -enhanced magnetic resonance imaging of small animals are conducted, revealing obvious signals after subcutaneous and intravenous injection, respectively. Due to the strong X-ray absorption and high atomic number of lanthanide elements, X-ray computed-tomography imaging based on PEG-UCNPs is then designed and carried out, achieving excellent imaging outcome in animal experiments. This is the first example of the usage of hybrid lutetium oxide nanoparticles as effective nanoprobes. Furthermore, biodistribution, clearance route, as well as long-term toxicity are investigated in detail after intravenous injection in a murine model, indicating the overall safety of PEG-UCNPs. Compared with previous lanthanide fluorides, our nanoprobes exhibit more advantages, such as facile construction process and nearly total excretion from the animal body within a month. Taken together, these results promise the use of PEG-UCNPs as a safe and efficient nanoparticulate contrast agent for potential application in multimodal imaging.

  10. ABAB homoleptic bis(phthalocyaninato)lutetium(III) complex: toward the real octupolar cube and giant quadratic hyperpolarizability.

    PubMed

    Ayhan, Mehmet Menaf; Singh, Anu; Hirel, Catherine; Gürek, Ayşe Gül; Ahsen, Vefa; Jeanneau, Erwann; Ledoux-Rak, Isabelle; Zyss, Joseph; Andraud, Chantal; Bretonnière, Yann

    2012-02-29

    The concept of octupolar molecules has considerably enlarged the engineering of second-order nonlinear optical materials by giving access to 2D and 3D architectures. However, if the archetype of octupolar symmetry is a cube with alternating donor and acceptor groups at the corners, no translation of this ideal structure into a real molecule has been realized to date. This may be achieved by designing a bis(phthalocyaninato)lutetium(III) double-decker complex with a crosswise ABAB phthalocyanine bearing alternating electron-donor and electron-acceptor groups. In this communication, we present the first step toward this goal with the synthesis, crystal structure determination, and measurement of the molecular first-order hyperpolarizability β by harmonic light diffusion, of an original lutetium(III) sandwich complex displaying the required ABAB-type alternation for one face of the cube. This structure is characterized by an intense absorption in the near-IR due to an intervalence transition and exhibits the highest quadratic hyperpolarizability ever reported for an octupolar molecule, √<β(2)(HLS)> = 5750 × 10(-30) esu.

  11. Piano-stool lutetium amido and imido compounds supported by a constrained bis(oxazoline)cyclopentadienyl ligand

    DOE PAGES

    Lampland, Nicole L.; Zhu, Jing; Hovey, Megan; ...

    2015-06-25

    {BoMCptet}Lu(CH2Ph)2 (1; BoMCptet = MeC(OxMe2 2C5Me4; OxMe2 = 4,4-dimethyl-2-oxazoline) was prepared in 95% yield from the reaction of BoMCptetH and Lu(CH2Ph)3THF3. Compound 1 reacts with 1 or 2 equiv of H2NCH2R (R = C6H5, 1-C10H7) to give the corresponding imido complexes [{BoMCptet}LuNCH2R]2 (R = C6H5 (2a), 1-C10H7 (2b)) or amido complexes {BoMCptet}Lu(NHCH2R)2 (R = C6H5 (3a), 1-C10H7 (3b)). When isolated, the imido species are insoluble in nonprotic organic solvents. Crystallographic characterization reveals dimeric [{BoMCptet}LuNCH2(1-C10H7)]2 in the solid state. The reaction of 1 and NH3B(C6F5)3 affords crystallographically characterized {BoMCptet}Lu{NHB(C6F5)2}C6F5. This species is proposed to form via a transient lutetium imido, whichmore » undergoes C6F5 migration to the lutetium center.« less

  12. MicroRNA-187 exerts tumor-suppressing functions in osteosarcoma by targeting ZEB2

    PubMed Central

    Fei, Dan; Zhao, Kunchi; Yuan, Hongping; Xing, Jie; Zhao, Dongxu

    2016-01-01

    MicroRNA-187 (miR-187) has been reported to be involved in the occurrence and development of several types of cancers; however, a role for miR-187 in osteosarcoma (OS) has not yet been reported. Here, miR-187 was found to be significantly downregulated in OS cell lines and tissue samples, and decreased miR-187 expression was shown to be correlated closely with the TNM stage and lymph node metastasis. miR-187 overexpression suppressed OS cell proliferation, colony formation, migration, invasion, and epithelial-mesenchymal transition (EMT). Mechanically, zinc finger E-box binding homeobox 2 (ZEB2) was shown to serve as a direct target of miR-187 in OS cells and the overexpression of ZEB2 rescued the miR-187-induced suppression of proliferation, colony formation, migration, and invasion in OS cells. In clinical OS specimens, ZEB2 expression levels were elevated and were inversely correlated with miR-187 expression. These results suggest that miR-187 functions as a tumor suppressor in OS, partially by targeting ZEB2, and that miR-187 can serve as a promising candidate for OS. PMID:28042505

  13. New Applications of the Re-187 - Os-187 and Pt-190 - Os-186 Isotope Systems to the Study of Iron Meteorites

    NASA Technical Reports Server (NTRS)

    Cook, D. L.; Walker, R. J.; Horan, M. F.

    2000-01-01

    Re-187 - Os-187 and Pt-190 - Os-186 isotope systems are applied to dating evolved iron meteorites. The Re-Os systematics of some evolved irons may indicate late stage system closure. This conclusion appears to be supported by a "young" Pt-Os isochron age.

  14. Re-187-Os-187, Pt-190-Os-186 Isotopic and Highly Siderophile Element Systematics of Group IVA Irons

    NASA Technical Reports Server (NTRS)

    Walker, R. J.; McCoy, T. J.; Schulte, R. F.; McDonough, W. F.; Ash, R. D.

    2005-01-01

    We have recently completed Re-187-Os-187 and Pt-190-Os-186 isotopic and elemental studies of the two largest magmatic iron meteorite groups, IIAB and IIIAB [1]. These studies revealed closed-system behavior of both isotopic systems, but complex trace element behavior for Re, Pt and Os in group IIIAB. Here we examine isotopic and trace elemental systematics of group IVA irons. The IVA irons are not as extensively fractionated as IIAB and IIIAB and their apparently less complex crystallization history may make for more robust interpretation of the relative partitioning behavior of Re, Pt and Os, as well as the other highly siderophile elements (HSE) measured here; Pd, Ru and Ir [e.g. 2]. An additional goal of our continuing research plan for iron meteorites is to assess the possibility of relating certain ungrouped irons with major groups via trace element modeling. Here, the isotopic and trace element systematics of the ungrouped irons Nedagolla and EET 83230 are compared with the IVA irons.

  15. Bis(tetrabenzotriazaporphyrinato) and (tetrabenzotriazaporphyrinato)(phthalocyaninato) lutetium(III) complexes--novel sandwich-type tetrapyrrolic ligand based NIR absorbing electrochromes.

    PubMed

    Pushkarev, Victor E; Kalashnikov, Valery V; Trashin, Stanislav A; Borisova, Nataliya E; Tomilova, Larisa G; Zefirov, Nikolay S

    2013-09-14

    The first sandwich-type complexes have been prepared for tetrabenzotriazaporphyrin ligands. The compounds reveal intrinsic UV-Vis/NIR absorption as well as peculiar electrochromic behavior. The heteroleptic (tetrabenzotriazaporphyrinato)(phthalocyaninato) lutetium derivative shows intermediate spectral and electrochemical properties with respect to homoleptic relatives.

  16. Lutetium oxyorthosilicate block detector readout by avalanche photodiode arrays for high resolution animal PET.

    PubMed

    Pichler, B J; Swann, B K; Rochelle, J; Nutt, R E; Cherry, S R; Siegel, S B

    2004-09-21

    Avalanche photodiodes (APDs) have proven to be useful as light detectors for high resolution positron emission tomography (PET). Their compactness makes these devices excellent candidates for replacing bulky photomultiplier tubes (PMTs) in PET systems where space limitations are an issue. The readout of densely packed, 10 x 10 lutetium oxyorthosilicate (LSO) block detectors (crystal size 2.0 x 2.0 x 12 mm3) with custom-built monolithic 3 x 3 APD arrays was investigated. The APDs had a 5 x 5 mm2 active surface and were arranged on a 6.25 mm pitch. The dead space on the edges of the array was 1.25 mm. The APDs were operated at a bias voltage of approximately 380 V for a gain of 100 and a dark current of 10 nA per APD. The standard deviation in gain between the APDs in the array ranged from 1.8 to 6.5% as the gain was varied from 50 to 108. A fast, low-noise, multi-channel charge sensitive preamplifier application-specific integrated circuit (ASIC) was developed for the APD readout. The amplifier had a rise time of 8 ns, a noise floor of 515 e- rms and a 9 e- pF(-1) noise slope. An acquired flood image showed that all 100 crystals from the block detector could be resolved. Timing measurements with single-channel LSO-APD detectors, as well as with the array, against a plastic scintillator and PMT assembly showed a time resolution of 1.2 ns and 2.5 ns, respectively. The energy resolution measured with a single 4.0 x 4.0 x 10 mm3 LSO crystal, wrapped in four-layer polytetrafluoroethylene (PTFE) tape and coupled with optical grease on a single APD of the array, yielded 15% (full width at half maximum, FWHM) at 511 keV. Stability tests over 9 months of operation showed that the APD arrays do not degrade appreciably. These results demonstrate the ability to decode densely packed LSO scintillation blocks with compact APD arrays. The good timing and energy resolution makes these detectors suitable for high resolution PET.

  17. Influence of cations on the complexation yield of DOTATATE with yttrium and lutetium: a perspective study for enhancing the 90Y and 177Lu labeling conditions.

    PubMed

    Asti, Mattia; Tegoni, Matteo; Farioli, Daniela; Iori, Michele; Guidotti, Claudio; Cutler, Cathy S; Mayer, Pat; Versari, Annibale; Salvo, Diana

    2012-05-01

    The DOTA macrocyclic ligand can form stable complexes with many cations besides yttrium and lutetium. For this reason, the presence of competing cationic metals in yttrium-90 and lutetium-177 chloride solutions can dramatically influence the radiolabeling yield. The aim of this study was to evaluate the coordination yield of yttrium- and lutetium-DOTATATE complexes when the reaction is performed in the presence of varying amounts of competing cationic impurities. In the first set of experiments, the preparation of the samples was performed by using natural yttrium and lutetium (20.4 nmol). The molar ratio between DOTATATE and these metals was 1 to 1. Metal competitors (Pb(2+), Zn(2+), Cu(2+), Fe(3+), Al(3+), Ni(2+), Co(2+), Cr(3+)) were added separately to obtain samples with varying molar ratio with respect to yttrium or lutetium (0.1, 0.5, 1, 2 and 10). The final solutions were analyzed through ultra high-performance liquid chromatography with an UV detector. In the second set of experiments, an amount of (90)Y or (177)Lu chloride (6 MBq corresponding to 3.3 and 45 pmol, respectively) was added to the samples, and a radio-thin layer chromatography analysis was carried out. The coordination of Y(3+) and Lu(3+) was dramatically influenced by low levels of Zn(2+), Cu(2+) and Co(2+). Pb(2+) and Ni(2+) were also shown to be strong competitors at higher concentrations. Fe(3+) was expected to be a strong competitor, but the effect on the incorporation was only partly dependent on its concentration. Al(3+) and Cr(3+) did not compete with Y(3+) and Lu(3+) in the formation of DOTATATE complexes.

  18. On the use of X-ray absorption spectroscopy to elucidate the structure of lutetium adenosine mono- and triphosphate complexes.

    PubMed

    Mostapha, S; Berthon, C; Fontaine-Vive, F; Gaysinski, M; Guérin, L; Guillaumont, D; Massi, L; Monfardini, I; Solari, P L; Thomas, O P; Charbonnel, M C; Den Auwer, C

    2014-02-01

    Although the physiological impact of the actinide elements as nuclear toxicants has been widely investigated for half a century, a description of their interactions with biological molecules remains limited. It is however of primary importance to better assess the determinants of actinide speciation in cells and more generally in living organisms to unravel the molecular processes underlying actinide transport and deposition in tissues. The biological pathways of this family of elements in case of accidental contamination or chronic natural exposure (in the case of uranium rich soils for instance) are therefore a crucial issue of public health and of societal impact. Because of the high chemical affinity of those actinide elements for phosphate groups and the ubiquity of such chemical functions in biochemistry, phosphate derivatives are considered as probable targets of these cations. Among them, nucleotides and in particular adenosine mono- (AMP) and triphosphate (ATP) nucleotides occur in more chemical reactions than any other compounds on the earth's surface, except water, and are therefore critical target molecules. In the present study, we are interested in trans-plutonium actinide elements, in particular americium and curium that are more rarely considered in environmental and bioaccumulation studies than early actinides like uranium, neptunium and plutonium. A first step in this strategy is to work with chemical analogues like lanthanides that are not radioactive and therefore allow extended physical chemical characterization to be conducted that are difficult to perform with radioactive materials. We describe herein the interaction of lutetium(III) with adenosine AMP and ATP. With AMP and ATP, insoluble amorphous compounds have been obtained with molar ratios of 1:2 and 1:1, respectively. With an excess of ATP, with 1:2 molar ratio, a soluble complex has been obtained. A combination of spectroscopic techniques (IR, NMR, ESI-MS, EXAFS) together with quantum

  19. Syntheses, Structure, Magnetism, and Optical Properties of Lutetium-based Interlanthanide Selenides

    SciTech Connect

    Booth, Corwin H; Jin, Geng Bang; Choi, Eun Sang; Guertin, Robert P.; Brooks, James S.; Booth, Corwin H.; Albrecht-Schmitt, Thomas E.

    2007-10-01

    Ln{sub 3}LuSe{sub 6} (Ln = La, Ce), {beta}-LnLuSe{sub 3} (Ln = Pr, Nd), and Ln{sub x}Lu{sub 4-x}Se{sub 6} (Ln = Sm, Gd; x = 1.82, 1.87) have been synthesized using a Sb{sub 2}Se{sub 3} flux at 1000 C. Ln{sub 3}LuSe{sub 6} (Ln = La, Ce) adopt the U{sub 3}ScS{sub 6}-type three-dimensional structure, which is constructed from two-dimensional {infinity}{sup 2} [Ln{sub 3}Se{sub 6}]{sup 3-} slabs with the gaps between these slabs filled by octahedrally coordinated Lu{sup 3+} ions. The series of {beta}-LnLuSe{sub 3} (Ln = Pr, Nd) are isotypic with UFeS{sub 3}. Their structures include layers formed from LuSe6 octahedra that are separated by eight-coordinate larger Ln{sup 3+} ions in bicapped trigonal prismatic environments. Sm{sub 1.82}Lu{sub 2.18}Se{sub 6} and Gd{sub 1.87}Lu{sub 2.13}Se{sub 6} crystallize in the disordered F-Ln{sub 2}S{sub 3} type structure with the eight-coordinate bicapped trigonal prismatic Ln(1) ions residing in the one-dimensional channels formed by three different double chains via edge and corner sharing. These double chains are constructed from Ln(2)Se{sub 7} monocapped trigonal prisms, Ln(3)Se{sub 6} octahedra, and Ln(4)S{sub 6} octahedra, respectively. The magnetic susceptibilities of {beta}-PrLuSe{sub 3} and {beta}-NdLuSe{sub 3} follow the Curie-Weiss law. Sm{sub 1.82}Lu{sub 2.18}Se{sub 6} shows van Vleck paramagnetism. Magnetic measurements show that Gd{sub 1.87}Lu{sub 2.13}Se{sub 6} undergoes an antiferromagnetic transition around 4 K. Ce{sub 3}LuSe{sub 6} exhibits ferromagnetic ordering below 5 K. The optical band gaps for La{sub 3}LuSe{sub 6}, Ce{sub 3}LuSe{sub 6}, {beta}- PrLuSe{sub 3}, {beta}-NdLuSe{sub 3}, Sm{sub 1.82}Lu{sub 2.18}Se{sub 6}, and Gd{sub 1.87}Lu{sub 2.13}Se{sub 6} are 1.26, 1.10, 1.56, 1.61, 1.51, and 1.56 eV, respectively.

  20. Raman scattering in organic semiconductors based on erbium biphthalocyanine molecules and chlorine-containing europium-lutetium triphthalocyanine molecules

    SciTech Connect

    Belogorokhov, I. A.; Mamichev, D. A.; Dronov, M. A.; Pushkarev, V. E.; Tomilova, L. G.; Khokhlov, D. R.

    2010-08-15

    The Raman spectra of semiconductor structures based on erbium biphthalocyanine molecules and chlorine-substituted europium-lutetium triphthalocyanine molecules are studied on excitation with Ar{sup +} laser radiation at the wavelength 514 nm. The data on the spectral position of Raman intensity peaks related to vibronic states of the basic molecular groups forming the semiconductor are obtained. Raman lines irrelevant to the known vibronic states of the basic phthalocyanine molecular groups are observed in the ranges 100-500 and 500-900 cm{sup -1}. It is shown that, in the spectra of triphthalocyanine, some lines are structurally complex and shifted with respect to the characteristic lines of molecular groups by several inverse centimeters.

  1. In situ chemichromic studies of interactions between a lutetium bis-octaalkyl-substituted phthalocyanine and selected biological cofactors.

    PubMed

    Pal, C; Cammidge, A N; Cook, M J; Sosa-Sanchez, J L; Sharma, A K; Ray, A K

    2012-01-07

    Spin-coated films, approximately 100 nm thick, of a newly synthesized bis[octakis(octyl)phthalocyaninato] lutetium(III) complex on ultrasonically cleaned glass substrates exhibit pronounced chemichromic behaviour with potential application in healthcare. In situ kinetic optical absorption spectroscopic measurements show that the phthalocyanine Q-band is red shifted by 60 nm upon oxidation arising from exposure to bromine vapour. Recovery to the original state is achieved by the treatment of the oxidized films with nicotinamide adenine dinucleotide and l-ascorbic acid (vitamin C) in an aqueous solution containing 1.5 M lithium perchlorate. The neutralization process is found to be governed by first-order kinetics. The linear increase of the reduction rate with increasing concentration of cofactors provides a basis for calibration of analyte concentrations ranging from 3.5 mM down to 0.03 mM.

  2. Nonlinear optical properties of lutetium and dysprosium bisphthalocyanines at 1550 nm with femto- and nanosecond pulse excitation

    NASA Astrophysics Data System (ADS)

    Plekhanov, A. I.; Basova, T. V.; Parkhomenko, R. G.; Gürek, A. G.

    2017-02-01

    In this work, the nonlinear optical properties of unsubstituted lutetium (LuPc2) and dysprosium (DyPc2) bisphthalocyanines as well as octasubstituted Lu(PcR8)2 derivative with R=-S(C6H13) were studied at a wavelength of 1550 nm with 10 ns and 300 fs pulses. Based on Z-scan measurements the nonlinear absorption and refraction coefficient as well as the nature of nonlinear optical properties were analyzed for these materials. Open aperture Z-scan indicates strong two-photon absorption in all three bisphthalocyanines in nano- and femtosecond regimes. With good nonlinear optical coefficients, bisphthalocyanines of rare earth elements are expected to be promising materials for the creation of optical limiters.

  3. In situ chemichromic studies of interactions between a lutetium bis-octaalkyl-substituted phthalocyanine and selected biological cofactors

    PubMed Central

    Pal, C.; Cammidge, A. N.; Cook, M. J.; Sosa-Sanchez, J. L.; Sharma, A. K.; Ray, A. K.

    2012-01-01

    Spin-coated films, approximately 100 nm thick, of a newly synthesized bis[octakis(octyl)phthalocyaninato] lutetium(III) complex on ultrasonically cleaned glass substrates exhibit pronounced chemichromic behaviour with potential application in healthcare. In situ kinetic optical absorption spectroscopic measurements show that the phthalocyanine Q-band is red shifted by 60 nm upon oxidation arising from exposure to bromine vapour. Recovery to the original state is achieved by the treatment of the oxidized films with nicotinamide adenine dinucleotide and l-ascorbic acid (vitamin C) in an aqueous solution containing 1.5 M lithium perchlorate. The neutralization process is found to be governed by first-order kinetics. The linear increase of the reduction rate with increasing concentration of cofactors provides a basis for calibration of analyte concentrations ranging from 3.5 mM down to 0.03 mM. PMID:21676969

  4. Low-damping sub-10-nm thin films of lutetium iron garnet grown by molecular-beam epitaxy

    NASA Astrophysics Data System (ADS)

    Jermain, C. L.; Paik, H.; Aradhya, S. V.; Buhrman, R. A.; Schlom, D. G.; Ralph, D. C.

    2016-11-01

    We analyze the structural and magnetic characteristics of (111)-oriented lutetium iron garnet (Lu3Fe5O12) films grown by molecular-beam epitaxy, for films as thin as 2.8 nm. Thickness-dependent measurements of the in- and out-of-plane ferromagnetic resonance allow us to quantify the effects of two-magnon scattering, along with the surface anisotropy and the saturation magnetization. We achieve effective damping coefficients of 11.1 (9 )×10-4 for 5.3 nm films and 32 (3 )×10-4 for 2.8 nm films, among the lowest values reported to date for any insulating ferrimagnetic sample of comparable thickness.

  5. Sandqvist 187 - A dense molecular cloud in Norma

    NASA Technical Reports Server (NTRS)

    Alvarez, H.; Bronfman, L.; Cohen, R.; Garay, G.; Graham, J.; Thaddeus, P.

    1986-01-01

    Observations of Sandqvist 187, an elongated dust cloud in the southern constellation Norma are presented and discussed. The cloud contains two Herbig-Haro objects, HH 56 and HH 57. HH 57 currently displays on its NE edge a 17th mag variable star of the FU Ori type. Using the Columbia University 1.2 m millimeter-wave telescope at Cerro Tololo, the region is mapped and an extended CO cloud which envelops and is elongated along the optical dust cloud is found. The position of maximum CO emission coincides with HH 56 and HH 57. Assuming a distance of 0.7 kpc, the total mass of the cloud is found to be close to 500 solar masses. The CO spectra show evidence of a molecular flow. Photographs and CCD images obtained mostly with the CTIO 4 m telescope show the detailed optical structure of the dark cloud's core region. The Herbig-Haro object HH 56 appears to be related to an emission-line star embedded in the small nebula Reipurth 13, not to the FU Ori star in HH 57.

  6. Simultaneous observations of the BL Lacertae object I Zw 187

    NASA Technical Reports Server (NTRS)

    Bregman, J. N.; Glassgold, A. E.; Huggins, P. J.; Pollock, J. T.; Pica, A. J.; Smith, A. G.; Webb, J. R.; Ku, W. H.-M.; Rudy, R. J.; Levan, P. D.

    1982-01-01

    Two sets of simultaneous spectra consisting of data obtained with radio, IR, optical, UV and X-ray telescopes were obtained 10 months apart for the X-ray bright BL Lac object IZw 187. In addition, nonsimultaneous observations were made in several of the aforementioned observing bands in order to detect flux variations and galactic light contamination was removed from all observations. The BL Lac component is found to have a weak 3000 A bump superposed on an IR-optical-UV spectrum of slope 0.9. Consistent with the arising of the IR-through-X-ray continuum from a single synchrotron source, the X-ray data fall on or near an extrapolation of this power law. No flux variations have been detected in the flat radio spectrum. Optical and X-ray fluxes are observed to vary by a factor not greater than three, and the shortest variability time scales in these bands are comparable at about one week.

  7. Updated results of a phase I trial of motexafin lutetium-mediated interstitial photodynamic therapy in patients with locally recurrent prostate cancer.

    PubMed

    Verigos, Kosmas; Stripp, Diana C Hsiung; Mick, Rosemarie; Zhu, Timothy C; Whittington, Richard; Smith, Debbie; Dimofte, Andreea; Finlay, Jarod; Busch, Theresa M; Tochner, Zelig A; Malkowicz, S; Glatstein, Eli; Hahn, Stephen M

    2006-01-01

    Locally recurrent prostate cancer after treatment with radiation therapy is a clinical problem with few acceptable treatments. One potential treatment, photodynamic therapy (PDT), is a modality that uses laser light, drug photosensitizer, and oxygen to kill tumor cells through direct cellular cytotoxicity and/or through destruction of tumor vasculature. A Phase I trial of interstitial PDT with the photosensitizer Motexafin lutetium was initiated in men with locally recurrent prostate cancer. In this ongoing trial, the primary objective is to determine the maximally tolerated dose of Motexafin lutetium-mediated PDT. Other objectives include evaluation of Motexafin lutetium uptake from prostate tissue using a spectrofluorometric assay and evaluation of optical properties in the human prostate. Fifteen men with biopsy-proven locally recurrent prostate cancer and no evidence of distant metastatic disease have been enrolled and 14 have been treated. Treatment plans were developed using transrectal ultrasound images. The PDT dose was escalated by increasing the Motexafin lutetium dose, increasing the 732 ran light dose, and decreasing the drug-light interval. Motexafin lutetium doses ranged from 0.5 to 2 mg/kg administered IV 24, 6, or 3 hr prior to 732 ran light delivery. The light dose, measured in real time with in situ spherical detectors was 25-100 J/cm2. Light was delivered via optical fibers inserted through a transperineal brachytherapy template in the operating room. Optical property measurements were made before and after light therapy. Prostate biopsies were obtained before and after light delivery for spectrofluorometric measurements of photosensitizer uptake. Fourteen patients have completed protocol treatment on eight dose levels without dose-limiting toxicity. Grade I genitourinary symptoms that are PDT related have been observed. One patient had Grade II urinary urgency that was urinary catheter related. No rectal or other gastrointestinal PDT-related tox

  8. 187Os/186Os in Lunar and Meteoritic Materials

    NASA Astrophysics Data System (ADS)

    Birck, J. L.; Allegre, C. J.

    1993-07-01

    The unique potentiallity of the ^187Re-^1870s radiochronometer stems from the chemical properties of the 2 elements. Their siderophilic nature has made the dating of the metal phase of iron meteorites and chondrites possible [1,2]. In silicate crystallization or melting, Os behaves as a strongly compatible element [3]. For Re the results hereunder show that its behavior is highly variable, depending on context. The development of the highly sensitive negative thermal ionization mass spectrometry [4,5] made possible the extensive analysis of silicate materials. We developed a chemical separation method allowing the analysis of 0,5 g of silicate with an Os blank of 0.3 pg (1pg=10^-12 g). The isotopic measurement of Os has a typical precision of a few permil for 1 pg of Os. A variety of samples has been investigated. Iron Meteorites: The main purpose of this study was to shed some light on the history of Kodaikanal. The silicate inclusions of this meteorite were reset at 3.7 Ga for both the Rb-Sr and the U-Pb chronometers [6,7]. The data from Coahuila, Canyon Diablo, Tlacotepec, and North Chile plot within 1% on the same isochron along with 3 samples from 2 locations inside the meteorite of Kodaikanal. As a consequence the Kodaikanal parent body did not form at 3.7 Ga but at about the same time as the parent bodies of the the majority of the other iron meteorites (~4.5 Ga). The only difference is that Kodaikanal suffered a strong secondary event at 3.7 Ga, which reset Rb/Sr and U-Pb chronometers but did not fractionate the Re/Os ratio. This result has already been suggested by our earlier work [8]. The St Severin Chondrite: A bulk sample and several batches of the metal separated from this chondrite were analysed. They plot on the iron meteorite isochron. However this metal is heterogeneous in Re/Os by a factor of at least 2 and indicates an uncomplete homogeinization of Re/Os between metal grains during parent body metamorphism. Basaltic Materials: Basaltic

  9. 34 CFR 403.187 - How may a State provide technical assistance?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... under § 403.180(b)(1) for the Secondary School Vocational Education Program and the Postsecondary and... 34 Education 3 2010-07-01 2010-07-01 false How may a State provide technical assistance? 403.187 Section 403.187 Education Regulations of the Offices of the Department of Education (Continued) OFFICE...

  10. Proposition 187: An Effective Measure To Deter Undocumented Migration to California?

    ERIC Educational Resources Information Center

    Alarcon, Rafael

    In 1994, California voters approved Proposition 187, which prohibits provision of publicly funded education and social services to undocumented immigrants, and which requires public schools to verify the legal status of students and their parents. This paper examines socioeconomic and immigration trends leading to the emergence of Proposition 187,…

  11. 50 CFR 218.187 - Renewal of Letters of Authorization and adaptive management.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 9 2011-10-01 2011-10-01 false Renewal of Letters of Authorization and adaptive management. 218.187 Section 218.187 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE... Authorization are restricted to: (1) New cited information and data indicating that the determinations made...

  12. 50 CFR 218.187 - Renewal of Letters of Authorization and adaptive management.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 10 2012-10-01 2012-10-01 false Renewal of Letters of Authorization and adaptive management. 218.187 Section 218.187 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE... Authorization are restricted to: (1) New cited information and data indicating that the determinations made...

  13. 14 CFR 121.187 - Airplanes: Reciprocating engine-powered: Landing limitations: Alternate airport.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...: Landing limitations: Alternate airport. 121.187 Section 121.187 Aeronautics and Space FEDERAL AVIATION...: Alternate airport. (a) No person may list an airport as an alternate airport in a dispatch or flight release unless the airplane (at the weight anticipated at the time of arrival at the airport), based on...

  14. 14 CFR 121.187 - Airplanes: Reciprocating engine-powered: Landing limitations: Alternate airport.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...: Landing limitations: Alternate airport. 121.187 Section 121.187 Aeronautics and Space FEDERAL AVIATION...: Alternate airport. (a) No person may list an airport as an alternate airport in a dispatch or flight release unless the airplane (at the weight anticipated at the time of arrival at the airport), based on...

  15. 9 CFR 381.187 - Cooperation of States for the interstate shipment of poultry products.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... interstate shipment of poultry products. 381.187 Section 381.187 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY ORGANIZATION AND TERMINOLOGY; MANDATORY MEAT AND POULTRY PRODUCTS INSPECTION AND VOLUNTARY INSPECTION AND CERTIFICATION POULTRY PRODUCTS INSPECTION...

  16. 9 CFR 381.187 - Cooperation of States for the interstate shipment of poultry products.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... interstate shipment of poultry products. 381.187 Section 381.187 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY ORGANIZATION AND TERMINOLOGY; MANDATORY MEAT AND POULTRY PRODUCTS INSPECTION AND VOLUNTARY INSPECTION AND CERTIFICATION POULTRY PRODUCTS INSPECTION...

  17. 9 CFR 381.187 - Cooperation of States for the interstate shipment of poultry products.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... interstate shipment of poultry products. 381.187 Section 381.187 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY ORGANIZATION AND TERMINOLOGY; MANDATORY MEAT AND POULTRY PRODUCTS INSPECTION AND VOLUNTARY INSPECTION AND CERTIFICATION POULTRY PRODUCTS INSPECTION...

  18. 33 CFR Appendix B to Part 187 - Participating and Certified Titling Authorities

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Participating and Certified Titling Authorities B Appendix B to Part 187 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) BOATING SAFETY VESSEL IDENTIFICATION SYSTEM Pt. 187, App. B Appendix B...

  19. 33 CFR Appendix B to Part 187 - Participating and Certified Titling Authorities

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Participating and Certified Titling Authorities B Appendix B to Part 187 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) BOATING SAFETY VESSEL IDENTIFICATION SYSTEM Pt. 187, App. B Appendix B...

  20. 31 CFR 103.187 - Special measures against Myanmar Mayflower Bank and Asia Wealth Bank.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Mayflower Bank and Asia Wealth Bank. 103.187 Section 103.187 Money and Finance: Treasury Regulations... measures against Myanmar Mayflower Bank and Asia Wealth Bank. (a) Definitions. For purposes of this section... in Burma or in any jurisdiction. (4) Asia Wealth Bank means all headquarters, branches, and...

  1. 26 CFR 1.187-1 - Amortization of certain coal mine safety equipment.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 3 2011-04-01 2011-04-01 false Amortization of certain coal mine safety... Corporations (continued) § 1.187-1 Amortization of certain coal mine safety equipment. (a) Allowance of... coal mine safety equipment (as defined in § 1.187-2), based on a period of 60 months. Such...

  2. 26 CFR 1.187-1 - Amortization of certain coal mine safety equipment.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 3 2013-04-01 2013-04-01 false Amortization of certain coal mine safety... Corporations (continued) § 1.187-1 Amortization of certain coal mine safety equipment. (a) Allowance of... coal mine safety equipment (as defined in § 1.187-2), based on a period of 60 months. Such...

  3. 26 CFR 1.187-1 - Amortization of certain coal mine safety equipment.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 3 2014-04-01 2014-04-01 false Amortization of certain coal mine safety... Corporations (continued) § 1.187-1 Amortization of certain coal mine safety equipment. (a) Allowance of... coal mine safety equipment (as defined in § 1.187-2), based on a period of 60 months. Such...

  4. 26 CFR 1.187-1 - Amortization of certain coal mine safety equipment.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 3 2012-04-01 2012-04-01 false Amortization of certain coal mine safety... Corporations (continued) § 1.187-1 Amortization of certain coal mine safety equipment. (a) Allowance of... coal mine safety equipment (as defined in § 1.187-2), based on a period of 60 months. Such...

  5. 46 CFR 108.187 - Ventilation for brush type electric motors in classified spaces.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 4 2011-10-01 2011-10-01 false Ventilation for brush type electric motors in classified spaces. 108.187 Section 108.187 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) A-MOBILE OFFSHORE DRILLING UNITS DESIGN AND EQUIPMENT Construction and Arrangement Ventilation §...

  6. Piano-stool lutetium amido and imido compounds supported by a constrained bis(oxazoline)cyclopentadienyl ligand

    SciTech Connect

    Lampland, Nicole L.; Zhu, Jing; Hovey, Megan; Jana, Barun; Ellern, Arkady; Sadow, Aaron D.

    2015-06-25

    {BoMCptet}Lu(CH2Ph)2 (1; BoMCptet = MeC(OxMe2 2C5Me4; OxMe2 = 4,4-dimethyl-2-oxazoline) was prepared in 95% yield from the reaction of BoMCptetH and Lu(CH2Ph)3THF3. Compound 1 reacts with 1 or 2 equiv of H2NCH2R (R = C6H5, 1-C10H7) to give the corresponding imido complexes [{BoMCptet}LuNCH2R]2 (R = C6H5 (2a), 1-C10H7 (2b)) or amido complexes {BoMCptet}Lu(NHCH2R)2 (R = C6H5 (3a), 1-C10H7 (3b)). When isolated, the imido species are insoluble in nonprotic organic solvents. Crystallographic characterization reveals dimeric [{BoMCptet}LuNCH2(1-C10H7)]2 in the solid state. The reaction of 1 and NH3B(C6F5)3 affords crystallographically characterized {BoMCptet}Lu{NHB(C6F5)2}C6F5. This species is proposed to form via a transient lutetium imido, which undergoes C6F5 migration to the lutetium center.

  7. Re-187, recycling r-process elements through stars, and the age of the Galaxy.

    NASA Technical Reports Server (NTRS)

    Talbot, R. J., Jr.

    1973-01-01

    The enhanced beta-decay rate of ionized Re-187 in stars has been studied within the context of a detailed numerical model of the production of r-process elements and their recycling through stars during the course of galactic evolution. It is concluded that the enhanced decay rate does not significantly reduce the Re-Os chronometer age for the Galaxy. Consequently, the Re-187 beta-decay half-life and the Os-186/Os-187 neutron cross-section ratio remain as the significant uncertainties in this chronology. Unlike the uncertainties in other chronologies, both are amenable to laboratory measurements.

  8. A novel glucose sensor using lutetium phthalocyanine as redox mediator in reduced graphene oxide conducting polymer multifunctional hydrogel.

    PubMed

    Al-Sagur, H; Komathi, S; Khan, M A; Gurek, A G; Hassan, A

    2017-06-15

    Herein, we report a scalable synthesis of multifunctional conducting polyacrylic acid (PAA) hydrogel (MFH) integrated with reduced grapheme oxide (rGO), vinyl substituted polyaniline (VS-PANI) and lutetium Phthalocyanine (LuPc2) as three dimensional robust matrix for glucose oxidase (GOx) immobilization (PAA-rGO/VS-PANI/LuPc2/GOx-MFH). We have integrated the multicomponents such as PAA with rGO, and VS-PANI through free radical polymerization using methylene bis-acrylamide, and ammonium persulphate as the cross linker and initiator. The LuPc2 was then doped to form multifunctional hydrogel (PAA-rGO/VS-PANI/LuPc2-MFH). Finally, biosensor was fabricated by immobilizing GOx into PAA-rGO/VS-PANI/LuPc2-MFH and subsequently used for electrochemical detection of glucose. The PAA-rGO/VS-PANI/LuPc2/GOx-MFH biosensor exhibited high sensitivity (15.31μAmM(-1)cm(-2)) for the detection of glucose over a concentration range of 2-12mM with a low detection limit of 25µm. The PAA-rGO/VS-PANI/LuPc2-MFH biosensor showed a fast response time (1s) to the addition of glucose with high storage stability of 3 months. The real sample analysis reveals that PAA-rGO/VS-PANI/LuPc2/GOx-MFH could be effectively used as an electrochemical biosensor in industrial as well clinical diagnosis.

  9. Optimizing lutetium 177-anti-carbonic anhydrase IX radioimmunotherapy in an intraperitoneal clear cell renal cell carcinoma xenograft model.

    PubMed

    Muselaers, Constantijn H J; Oosterwijk, Egbert; Bos, Desirée L; Oyen, Wim J G; Mulders, Peter F A; Boerman, Otto C

    2014-01-01

    A new approach in the treatment of clear cell renal carcinoma (ccRCC) is radioimmunotherapy (RIT) using anti-carbonic anhydrase IX (CAIX) antibody G250. To investigate the potential of RIT with lutetium 177 (177Lu)-labeled G250, we conducted a protein dose escalation study and subsequently an RIT study in mice with intraperitoneally growing ccRCC lesions. Mice with intraperitoneal xenografts were injected with 1, 3, 10, 30, or 100 μg of G250 labeled with 10 MBq indium 111 (111In) to determine the optimal protein dose. The optimal protein dose determined with imaging and biodistribution studies was used in a subsequent RIT experiment in three groups of 10 mice with intraperitoneal SK-RC-52 tumors. One group received 13 MBq 177Lu-DOTA-G250, a control group received 13 MBq nonspecific 177Lu-MOPC21, and the second control group was not treated and received 20 MBq 111In-DOTA-G250. The optimal G250 protein dose to target ccRCC in this model was 10 μg G250. Treatment with 13 MBq 177Lu-DOTA-G250 was well tolerated and resulted in significantly prolonged median survival (139 days) compared to controls (49-53 days, p  =  .015), indicating that RIT has potential in this metastatic ccRCC model.

  10. Radiolabeling of substance P with lutetium-177 and biodistribution study in rat pancreatic tumor xenografted nude mice.

    PubMed

    De Araújo, E B; Pujatti, P B; Mengatti, J

    2010-05-10

    Pancreatic tumor (PT) is a neuroendocrine neoplasm that usually origin metastases in the respiratory and gastrointestinal tract. The presence of peptide receptors at the cell membrane of PT constitutes the basis of the clinical use of specific radiolabeled ligands for its diagnosis and targeted therapy. Substance P (SP), an 11-amino acid peptide which has an important role in modulating pain transmission trough neurokinin type 1 (NK1r) and 2 receptors (NK2r), may play a role in the pathogenesis of PT, because approximately 10% of these tumors overexpress NK1r. The aim of the present work was to produce a pure and stable SP analog (DOTA-SP) radiolabeled with lutetium-177 ((177)Lu), and to evaluate its in vivo target to AR42J pancreatic tumor cells in Nude mice, in other to verify if SP can be used in this pancreatic tumor detection and treatment. Substance P was successfully labeled with high yield (>99%) at optimized conditions and kept stable for more than 72 hours at 2-8 degrees C and 4 hours in human plasma. Biodistribution studies showed that SP excretion was mainly performed by renal pathway. In addition, (177)Lu-DOTA-SP showed higher uptake by tumor than normal pancreas, indicating the presence of NK receptors in AR42J pancreatic tumor.

  11. Spectroscopic refractive indices of monoclinic single crystal and ceramic Lutetium oxyorthosilicate (LSO) from 200 to 850 nm

    SciTech Connect

    Jellison Jr, Gerald Earle; Specht, Eliot D; Boatner, Lynn A; Singh, David J; Melcher, Charles L

    2012-01-01

    The four real values of the dielectric function tensor of the monoclinic crystal Lu2SiO5 or lutetium oxyorthosilicate (LSO) have been determined using generalized ellipsometry from 200 to 850 nm. The three principal values are fit to the Sellmeier model, and they indicate that the band gap of LSO is less than ~9 eV. The off-diagonal element 12 is non-zero over the entire spectrum, but it is very close to zero for wavelengths longer than ~400 nm, indicating that structurally monoclinic LSO is nearly optically orthorhombic in this wavelength region. The spectroscopic dielectric functions of three isotropic ceramic LSO samples are presented, which are consistent with the dielectric functions of single-crystal LSO when the effects of porosity are included. As a comparison, the dielectric functions are also determined using relativistic electronic structure and optical calculations based on the recently developed potential functional of Tran and Blaha (Phys. Rev. Lett. 102, 226401 (2009).)

  12. Photodynamic inactivation of pathogenic species Pseudomonas aeruginosa and Candida albicans with lutetium (III) acetate phthalocyanines and specific light irradiation.

    PubMed

    Mantareva, Vanya; Kussovski, Vesselin; Durmuş, Mahmut; Borisova, Ekaterina; Angelov, Ivan

    2016-11-01

    Photodynamic inactivation (PDI) is a light-associated therapeutic approach suitable for treatment of local acute infections. The method is based on specific light-activated compound which by specific irradiation and in the presence of molecular oxygen produced molecular singlet oxygen and other reactive oxygen species, all toxic for pathogenic microbial cells. The study presents photodynamic impact of two recently synthesized water-soluble cationic lutetium (III) acetate phthalocyanines (LuPc-5 and LuPc-6) towards two pathogenic strains, namely, the Gram-negative bacterium Pseudomonas aeruginosa and a fungus Candida albicans. The photodynamic effect was evaluated for the cells in suspensions and organized in 48-h developed biofilms. The relatively high levels of uptakes of LuPc-5 and LuPc-6 were determined for fungal cells compared to bacterial cells. The penetration depths and distribution of both LuPcs into microbial biofilms were investigated by means of confocal fluorescence microscopy. The photoinactivation efficiency was studied for a wide concentration range (0.85-30 μM) of LuPc-5 and LuPc-6 at a light dose of 50 J cm(-2) from red light-emitting diode (LED; 665 nm). The PDI study on microbial biofilms showed incomplete photoinactivation (<3 logs) for the used gentle drug-light protocol.

  13. 50 CFR 218.187 - Renewal of Letters of Authorization and adaptive management.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... GOVERNING THE TAKING AND IMPORTING OF MARINE MAMMALS Taking Marine Mammals Incidental to U.S. Navy Mission Activities in the Naval Surface Warfare Center Panama City Division § 218.187 Renewal of Letters...

  14. 50 CFR 218.187 - Renewal of Letters of Authorization and adaptive management.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... GOVERNING THE TAKING AND IMPORTING OF MARINE MAMMALS Taking Marine Mammals Incidental to U.S. Navy Mission Activities in the Naval Surface Warfare Center Panama City Division § 218.187 Renewal of Letters...

  15. Atmospheric model development in support of SEASAT. Volume 5: Test results with fine-mesh (187 by 187 by 10) model

    NASA Technical Reports Server (NTRS)

    Kesel, P. G.

    1977-01-01

    A model (187 x 187 grid with ten layers) was used to produce a 24 hour forecast using initial conditions for 1200Z, 20 May 1976. This forecast was compared to its five layer counterpart on the 187 x 187 grid and to its 63 x 63 coarse mesh counterpart having the same number of layers. Increases in horizontal resolution lead to significant differences in a one day forecast. Many of these differences represent improvements. Increases in vertical resolution tend to produce smaller impacts on the forecast, except in the region near and above the tropopause. The effect on forecast precipitation is in the 10-20% range, as opposed to the 100% for increases in the horizontal resolution. With respect to model energetics (kinetic energy; square vorticity; square divergence), the model tend to group according to horizontal resolution. The time variations of these parameters show that dynamic initialization is needed to: (1) minimize initialization shock; and (2) stabilize the model context to prevent wash-out of small scale information during the adjustment period (first 6-12 forecast hours).

  16. Osmium uptake, distribution, and 187Os/188Os and 187Re/188Os compositions in Phaeophyceae macroalgae, Fucus vesiculosus: Implications for determining the 187Os/188Os composition of seawater

    NASA Astrophysics Data System (ADS)

    Racionero-Gómez, B.; Sproson, A. D.; Selby, D.; Gannoun, A.; Gröcke, D. R.; Greenwell, H. C.; Burton, K. W.

    2017-02-01

    The osmium isotopic composition (187Os/188Os) of seawater reflects the balance of input from mantle-, continental- and anthropogenic-derived sources. This study utilizes the Phaeophyceae, Fucus vesiculosus, to analyse its Os abundance and uptake, as well as to assess if macroalgae records the Os isotope composition of the seawater in which it lives. The data demonstrates that Os is not located in one specific biological structure within macroalgae, but is found throughout the organism. Osmium uptake was measured by culturing F. vesiculosus non-fertile tips with different concentrations of Os with a known 187Os/188Os composition (∼0.16), which is significantly different from the background isotopic composition of local seawater (∼0.94). The Os abundance of cultured non-fertile tips show a positive correlation to the concentration of the Os doped seawater. Moreover, the 187Os/188Os composition of the seaweed equalled that of the culture medium, strongly confirming the possible use of macroalgae as a biological proxy for the Os isotopic composition of the seawater.

  17. Bioelectronic tongue based on lipidic nanostructured layers containing phenol oxidases and lutetium bisphthalocyanine for the analysis of grapes.

    PubMed

    Medina-Plaza, C; de Saja, J A; Rodriguez-Mendez, M L

    2014-07-15

    In this work, a multisensor system formed by nanostructured voltammetric biosensors based on phenol oxidases (tyrosinase and laccase) has been developed. The enzymes have been incorporated into a biomimetic environment provided by a Langmuir-Blodgett (LB) film of arachidic acid (AA). Lutetium bisphthalocyanine (LuPc2) has also been introduced in the films to act as electron mediator. The incorporation of the enzymes to the floating layers to form Tyr/AA/LuPc2 and Lac/AA/LuPc2 films has been confirmed by the expansion in the surface pressure isotherms and by the AFM images. The voltammetric response towards six phenolic compounds demonstrates the enhanced performance of the biosensors that resulted from a preserved activity of the tyrosinase and laccase combined with the electron transfer activity of LuPc2. Biosensors show improved detection limits in the range of 10(-7)-10(-8) mol L(-1). An array formed by three sensors AA/LuPc2, Tyr/AA/LuPc2 and Lac/AA/LuPc2 has been employed to discriminate phenolic antioxidants of interest in the food industry. The Principal Component Analysis scores plot has demonstrated that the multisensor system is able to discriminate phenols according to the number of phenolic groups attached to the structure. The system has also been able to discriminate grapes of different varieties according to their phenolic content. This good performance is due to the combination of four factors: the high functionality of the enzyme obtained using a biomimetic immobilization, the signal enhancement caused by the LuPc2 mediator, the improvement in the selectivity induced by the enzymes and the complementary activity of the enzymatic sensors demonstrated in the loading plots.

  18. Feasibility of repeated sequential treatments of RIF-1 tumors with photodynamic therapy (PDT) using lutetium texaphyrin (PCI-0123)

    NASA Astrophysics Data System (ADS)

    Miles, Dale R.; Parker, Lynn M.; Thiemann, Patricia A.; Woodburn, Kathryn W.; Young, Stuart W.

    1997-05-01

    Lutetium texaphyrin (PCI-0123) is currently in clinical trials as a PDT agent for the treatment of cancer patients. The drug is cleared rapidly from the plasma, and photoirradiation can be performed shortly after drug administration.T He photosensitizer as yet does not appear to elicit any significant skin photosensitivity. These characteristics favor frequent multiple PDT treatments with PCI-0123. In order to support repeated PDT treatments in the clinic, the safety of multiple drug dosing was studied in rats and mice. In rats, each group received 5 consecutive daily intravenous administrations of 5, 15, 30, or 60 mg/kg/day of PCI-0123. There were no deaths in any of the groups, and no drug-related effects were detected in the 5 mg/kg/day group. In mice, there were no observable signs of toxicity after consecutive daily administration of 10 micrometers ol/kg/day of PCI-0123 for 13 days. The feasibility and efficacy of repeated PDT treatments were assessed in C3H mice bearing RIF-1 tumors. Repeated PDT proved to be superior to a single PDT treatment. Repeated PDT treatments were well tolerated. Seven PDT treatments were administered over a nine day period without significant toxicity while achieving good therapeutic responses. All six groups receiving repeated PDT treatments showed an improved response compared to groups receiving a single PDT cycle, and the improvement was statistically significant for five of these groups. Sixty-two percent of mice receiving four sequential daily treatments were cured, and daily treatments were superior to regimens with longer intervals between PDT cycles.

  19. In vivo reflectance measurement of optical properties, blood oxygenation and motexafin lutetium uptake in canine large bowels, kidneys and prostates.

    PubMed

    Solonenko, Michael; Cheung, Rex; Busch, Theresa M; Kachur, Alex; Griffin, Gregory M; Vulcan, Theodore; Zhu, Timothy C; Wang, Hsing-Wen; Hahn, Stephen M; Yodh, A G

    2002-03-21

    Motexafin lutetium (MLu) is a second-generation photosensitizer for photodynamic therapy (PDT) of cancer. We have developed and applied a diffuse optical reflectance spectrometer for in vivo measurement of MLu uptake, optical properties, haemoglobin concentration and haemoglobin oxygen saturation in normal canine large bowels, kidneys and prostates. The probe consists of a broadband fibre-optic-coupled light source and detector fibres placed at various distances from the source fibre to collect reflected light. An analysis based on the diffusion approximation of the photon transport equation was used to recover tissue optical properties from the reflectance measurements. The instrumentation and analysis methods were validated using measurements from homogeneous, highly scattering phantoms with known MLu concentrations. The same techniques were then used to estimate chromophore concentrations of normal canine large bowels, kidneys and prostates. We estimated (mean (standard deviation)) total haemoglobin concentrations of 119 (25), 340 (92) and 51 (11) microM in the large bowels, kidneys and prostates of four dogs, respectively; tissue blood oxygen saturations in these same organs were 75 (15), 76 (21) and 74 (16) per cent, respectively. Tissue MLu concentrations (mg l(-1)) were estimated from data taken 3.5 h after injection of a 2 mg kg(-1) injected dose; data from three dogs gave concentrations of 2.4 (0.4) in large bowels, 6.8 (1.3) in kidneys and 2.2 (1.1) in prostates. The reduced scattering coefficients, mu's, estimated for large bowels, kidneys and prostates at 730 nm were, respectively: 10.1 (1.3), 19.6 (4.0) and 12.7 (0.6) cm(-1). We observed significant variability in MLu uptake, tissue scattering and haemoglobin concentration between organs and even between the same organ in different dogs. This class of in situ optical property measurement may be desirable to individualize PDT drug and light delivery.

  20. Chemoradiation therapy using cyclopamine-loaded liquid-lipid nanoparticles and lutetium-177-labeled core-crosslinked polymeric micelles.

    PubMed

    You, Jian; Zhao, Jun; Wen, Xiaoxia; Wu, Chunhui; Huang, Qian; Guan, Fada; Wu, Richard; Liang, Dong; Li, Chun

    2015-03-28

    Cyclopamine (CPA), a potent inhibitor of the Hedgehog pathway, has produced promising anticancer results in a number of preclinical studies. CPA has also been found to enhance tumor response to radiation therapy. However, CPA is water insoluble. A drug delivery system suitable for systemic administration of CPA is needed before CPA can be considered for clinical translation. We hypothesized that CPA solubilized in a liquid-lipid nanoparticle system (CPA-LLP) for intravenous injection would have desirable pharmacokinetic properties and increased anticancer efficacy. We further hypothesized that CPA-LLP would enhance the response of tumor cells to targeted radiotherapy delivered selectively through intratumoral injection of lutetium-177 bound to core-crosslinked polymeric micelles (CCPM-(177)Lu). We tested the combination therapy in 4T1 murine breast cancer and Miapaca-2 human pancreatic adenocarcinoma models. The results showed that CPA-LLP had higher antitumor cytotoxicity than free CPA (IC50 values [mean±SEM]: 2.7±0.2μM vs. 11.3±1.2μM against 4T1 cells; 1.8±0.2 vs. 17.1±1.26μM against Miapaca-2 cells; p<0.0001). In both cell lines, CPA-LLP resulted in significantly lower clonogenicity than free CPA (p<0.05). Moreover, in both cell lines, CPA-LLP significantly enhanced the cell response to CCPM-(177)Lu radiotherapy as measured by clonogenic assay (p<0.05). In 4T1 and Miapaca-2 mouse xenograft models, the combination of CPA-LLP and CCPM-(177)Lu delayed tumor growth more than either monotherapy did alone. In the 4T1 tumor model, tumor size at 16days after treatment was significantly smaller with the combination therapy than with all the other treatments. In the Miapaca-2 model, the combination therapy resulted in the highest rate of mouse survival and prevented tumor relapse. In conclusion, the combination of CPA-LLP and CCPM-(177)Lu was an effective strategy for treating breast and pancreatic cancer and deserves further investigation.

  1. Beta emitters rhenium-188 and lutetium-177 are equally effective in radioimmunotherapy of HPV-positive experimental cervical cancer.

    PubMed

    Phaeton, Rebecca; Jiang, Zewei; Revskaya, Ekaterina; Fisher, Darrell R; Goldberg, Gary L; Dadachova, Ekaterina

    2016-01-01

    Cervical cancer caused by the infection with the human papillomavirus (HPV) remains the fourth leading killer of women worldwide. Therefore, more efficacious treatments are needed. We are developing radioimmunotherapy (RIT) of HPV-positive cervical cancers by targeting E6 and E7 viral oncoproteins expressed by the cancer cells with the radiolabeled monoclonal antibodies (mAbs). To investigate the influence of different radionuclides on the RIT efficacy-we performed RIT of experimental cervical cancer with Rhenium-188 ((188) Re) and Lutetium-177 ((177) Lu)-labeled mAb C1P5 to E6. The biodistribution of (188) Re- and (177) Lu-labeled C1P5 was performed in nude female mice bearing CasKi cervical cancer xenografts and the radiation dosimetry calculations for the tumors and organs were carried out. For RIT the mice were treated with 7.4 MBq of either (188) Re-C1P5 or (177) Lu-C1P5 or left untreated, and observed for their tumor size for 28 days. The levels of (188) Re- and (177) Lu-C1P5 mAbs-induced double-strand breaks in CasKi tumors were compared on days 5 and 10 post treatment by staining with anti-gamma H2AX antibody. The radiation doses to the heart and lungs were similar for both (177) Lu-C1P5 and (188) Re-C1P5. The dose to the liver was five times higher for (177) Lu-C1P5. The doses to the tumor were 259 and 181 cGy for (177) Lu-C1P5 and (188) Re-C1P5, respectively. RIT with either (177) Lu-C1P5 or (188) Re-C1P5 was equally effective in inhibiting tumor growth when each was compared to the untreated controls (P = 0.001). On day 5 there was a pronounced staining for gamma H2AX foci in (177) Lu-C1P5 group only and on day 10 it was observed in both (177) Lu-C1P5 and (188) Re-C1P5 groups. (188) Re- and (177) Lu-labeled mAbs were equally effective in arresting the growth of CasKi cervical tumors. Thus, both of these radionuclides are candidates for the clinical trials of this approach in patients with advanced, recurrent or metastatic cervical cancer.

  2. 40 CFR 81.187 - Olympic-Northwest Washington Intrastate Air Quality Control Region.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...: Clallam County, Grays Harbor County, Island County, Jefferson County, Mason County, Pacific County, San... 40 Protection of Environment 17 2010-07-01 2010-07-01 false Olympic-Northwest Washington... Designation of Air Quality Control Regions § 81.187 Olympic-Northwest Washington Intrastate Air...

  3. The causes for geographical variations in OS187/OS186 at the Cretaceous-Tertiary boundary

    NASA Technical Reports Server (NTRS)

    Turekian, K. K.; Esser, B. K.; Ravizza, G. E.

    1988-01-01

    Researchers at Yale has approached the problem of the osmium isotopic composition of marine deposits formed in contact with both oxidized and reduced bottom waters. The measured (187) Os/(186) Os ratios of modern bulk sediment can be explained using mixing equations involving continental detrital, volcaniclastic, cosmogenic and hydrogeneous components. These studies show that sediments deposited under reducing marine conditions contain a hydrogenous component which is enriched in Re and has a radiogenic (187) Os/(186) Os ratio. The presence of such a hydrogenous component in the marine fish clay at Stevns Klint can account for the elevation of its (187) Os/(186) Os ration above the expected meteoritic value. Mass balance considerations require the Re/Os ratio of the phase precipitated from the terminal Cretaceous sea at Stevns Klint to have been about one tenth the value observed in contemporary deposits in the Black Sea, assuming Re has not been lost (or Os gained) subsequent to precipitation. In continental sections, the elevation of the (187) Os/(186) Os ratio in boundary layers may be due to precipitation from continental waters of crustally-derived radiogenic osmium either contemporaneous with the meteoritic (or mantle) osmium deposition or later during diagenesis.

  4. 46 CFR 108.187 - Ventilation for brush type electric motors in classified spaces.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...-MOBILE OFFSHORE DRILLING UNITS DESIGN AND EQUIPMENT Construction and Arrangement Ventilation § 108.187 Ventilation for brush type electric motors in classified spaces. Ventilation for brush type electric motors in... 46 Shipping 4 2014-10-01 2014-10-01 false Ventilation for brush type electric motors in...

  5. 46 CFR 108.187 - Ventilation for brush type electric motors in classified spaces.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...-MOBILE OFFSHORE DRILLING UNITS DESIGN AND EQUIPMENT Construction and Arrangement Ventilation § 108.187 Ventilation for brush type electric motors in classified spaces. Ventilation for brush type electric motors in... 46 Shipping 4 2013-10-01 2013-10-01 false Ventilation for brush type electric motors in...

  6. 46 CFR 108.187 - Ventilation for brush type electric motors in classified spaces.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...-MOBILE OFFSHORE DRILLING UNITS DESIGN AND EQUIPMENT Construction and Arrangement Ventilation § 108.187 Ventilation for brush type electric motors in classified spaces. Ventilation for brush type electric motors in... 46 Shipping 4 2012-10-01 2012-10-01 false Ventilation for brush type electric motors in...

  7. 14 CFR Appendix B to Part 187 - Fees for FAA Services for Certain Flights

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... either directly owned by the United States or allocated to the United States by the International Civil Aviation Organization (ICAO) or by other countries. This is further defined, for this section only, as... Appendix B to Part 187 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF...

  8. Intravitreal injection of a chimeric phage endolysin Ply187 protects mice from Staphylococcus aureus endophthalmitis

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Objectives: The treatment of endophthalmitis is becoming very challenging due to the emergence of multidrug-resistant bacteria. Hence, the development of novel therapeutic alternatives for ocular use is essential. Here, we evaluated the therapeutic potential of Ply187AN-KSH3b, a chimeric phage endol...

  9. 33 CFR 187.101 - What information must be collected to identify a vessel owner?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ..., DEPARTMENT OF HOMELAND SECURITY (CONTINUED) BOATING SAFETY VESSEL IDENTIFICATION SYSTEM Information to be Collected by Participating States § 187.101 What information must be collected to identify a vessel owner... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false What information must...

  10. 33 CFR 187.103 - What information must be collected to identify a vessel?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., DEPARTMENT OF HOMELAND SECURITY (CONTINUED) BOATING SAFETY VESSEL IDENTIFICATION SYSTEM Information to be Collected by Participating States § 187.103 What information must be collected to identify a vessel? A... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false What information must...

  11. 33 CFR 187.103 - What information must be collected to identify a vessel?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ..., DEPARTMENT OF HOMELAND SECURITY (CONTINUED) BOATING SAFETY VESSEL IDENTIFICATION SYSTEM Information to be Collected by Participating States § 187.103 What information must be collected to identify a vessel? A... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false What information must...

  12. 33 CFR 187.101 - What information must be collected to identify a vessel owner?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., DEPARTMENT OF HOMELAND SECURITY (CONTINUED) BOATING SAFETY VESSEL IDENTIFICATION SYSTEM Information to be Collected by Participating States § 187.101 What information must be collected to identify a vessel owner... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false What information must...

  13. 33 CFR 187.103 - What information must be collected to identify a vessel?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ..., DEPARTMENT OF HOMELAND SECURITY (CONTINUED) BOATING SAFETY VESSEL IDENTIFICATION SYSTEM Information to be Collected by Participating States § 187.103 What information must be collected to identify a vessel? A... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false What information must...

  14. 33 CFR 187.103 - What information must be collected to identify a vessel?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ..., DEPARTMENT OF HOMELAND SECURITY (CONTINUED) BOATING SAFETY VESSEL IDENTIFICATION SYSTEM Information to be Collected by Participating States § 187.103 What information must be collected to identify a vessel? A... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false What information must...

  15. 33 CFR 187.101 - What information must be collected to identify a vessel owner?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., DEPARTMENT OF HOMELAND SECURITY (CONTINUED) BOATING SAFETY VESSEL IDENTIFICATION SYSTEM Information to be Collected by Participating States § 187.101 What information must be collected to identify a vessel owner... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false What information must...

  16. National Ignition Facility subsystem design requirements final optics assembly subsystem SSDR 1.8.7

    SciTech Connect

    Adams, C.

    1996-10-20

    This SSDR establishes the performance, design, development and test requirements for the Final Optic Assembly (FOA). The FOA (WBS 1.8.7) as part of the Target Experimental System (1.8) includes vacuum windows, frequency conversion crystals, focus lens, debris shields and supporting mechanical equipment.

  17. 33 CFR 187.307 - What are dealer and manufacturer provisions?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false What are dealer and manufacturer... Systems § 187.307 What are dealer and manufacturer provisions? A State must include the following provisions applicable to any dealer or manufacturer building, buying, acquiring, selling, or transferring...

  18. PS187 - a good statistics study of antiproton interactions with nuclei: preliminary results

    SciTech Connect

    Sunier, J.W.; Bol, K.D.; Clover, M.R.; DeVries, R.M.; DiGiacomo, N.J.; Kapustinsky, J.S.; McGaughey, P.L.; Smith, G.R.; Sondheim, W.E.; Buenard, M.

    1984-01-01

    The goals of LEAR experiment PS187 are reviewed. The current status of the experiment is discussed, and final data on a search for anti p-nucleus bound states formed by the reactions /sup 28/Si(anti p,p) and /sup 28/Si(anti p,d) are presented.

  19. 34 CFR 222.187 - Which year's data must an SEA or LEA provide?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Which year's data must an SEA or LEA provide? 222.187... AND SECONDARY EDUCATION, DEPARTMENT OF EDUCATION IMPACT AID PROGRAMS Impact Aid Discretionary... data must an SEA or LEA provide? (a) Except as provided in paragraph (b) of this section, the...

  20. 26 CFR 1.187-1 - Amortization of certain coal mine safety equipment.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 3 2010-04-01 2010-04-01 false Amortization of certain coal mine safety... (continued) § 1.187-1 Amortization of certain coal mine safety equipment. (a) Allowance of deduction—(1) In... respect to the amortization of the adjusted basis (for determining gain) of any certified coal mine...

  1. 49 CFR 173.187 - Pyrophoric solids, metals or alloys, n.o.s.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 2 2011-10-01 2011-10-01 false Pyrophoric solids, metals or alloys, n.o.s. 173... Class 1 and Class 7 § 173.187 Pyrophoric solids, metals or alloys, n.o.s. Packagings for pyrophoric solids, metals, or alloys, n.o.s. must conform to the requirements of part 178 of this subchapter at...

  2. 49 CFR 173.187 - Pyrophoric solids, metals or alloys, n.o.s.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 2 2014-10-01 2014-10-01 false Pyrophoric solids, metals or alloys, n.o.s. 173... Class 1 and Class 7 § 173.187 Pyrophoric solids, metals or alloys, n.o.s. Packagings for pyrophoric solids, metals, or alloys, n.o.s. must conform to the requirements of part 178 of this subchapter at...

  3. 49 CFR 173.187 - Pyrophoric solids, metals or alloys, n.o.s.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Pyrophoric solids, metals or alloys, n.o.s. 173... Class 1 and Class 7 § 173.187 Pyrophoric solids, metals or alloys, n.o.s. Packagings for pyrophoric solids, metals, or alloys, n.o.s. must conform to the requirements of part 178 of this subchapter at...

  4. 49 CFR 173.187 - Pyrophoric solids, metals or alloys, n.o.s.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 2 2012-10-01 2012-10-01 false Pyrophoric solids, metals or alloys, n.o.s. 173... Class 1 and Class 7 § 173.187 Pyrophoric solids, metals or alloys, n.o.s. Packagings for pyrophoric solids, metals, or alloys, n.o.s. must conform to the requirements of part 178 of this subchapter at...

  5. 49 CFR 173.187 - Pyrophoric solids, metals or alloys, n.o.s.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 2 2013-10-01 2013-10-01 false Pyrophoric solids, metals or alloys, n.o.s. 173... Class 1 and Class 7 § 173.187 Pyrophoric solids, metals or alloys, n.o.s. Packagings for pyrophoric solids, metals, or alloys, n.o.s. must conform to the requirements of part 178 of this subchapter at...

  6. Up-regulation of miR-187 modulates the advances of oral carcinoma by targeting BARX2 tumor suppressor

    PubMed Central

    Lin, Shu-Chun; Kao, Shou-Yen; Chang, Jennifer Chen-Yu; Liu, Ying-Chieh; Yu, En-Hao; Tseng, Ssu-Hsueh; Liu, Chung-Ji; Chang, Kuo-Wei

    2016-01-01

    Oral squamous cell carcinoma (OSCC) is one of the most common cancers worldwide. Aberrations in miRNA regulation are known to play important roles in OSCC pathogenesis. miR-187 was shown to be up-regulated in head and neck malignancies in our previous screening. This study further investigated the oncogenic potential, clinical implications, and targets of miR-187 in OSCC. We observed that miR-187 increased oncogenicity, particularly migration, of OSCC cells. miR-187 expression increased the xenografic tumorigenicity and metastasis in mice. In addition, metastatic human OSCC had higher miR-187 expression than did non-metastatic tumors. Through vigorous screening, we confirmed BarH-like Homeobox 2 (BARX2) gene as an miR-187 target. BARX2 expression suppressed the migration, invasion, anchorage-independent colony formation, and orthotopic tumorigenesis of OSCC cells. The migratory phenotype and neck metastasis induced by miR-187 was rescued by BARX2 expression. BARX2 expression was down-regulated in the vast majority of OSCC, and this down-regulation was particularly conspicuous in tumors with advanced nodal metastasis. In addition, plasma miR-187 was significantly higher in OSCC patients than in normal individuals. This study highlights the roles of miR-187-BARX2 in driving the carcinogenesis of OSCC. The results suggest that miR-187 is a potential serological marker for OSCC and that targeting of miR-187 might prove effective in attenuating nodal metastasis. PMID:27542258

  7. Draft Genome Sequence of Enterobacter sp. Sa187, an Endophytic Bacterium Isolated from the Desert Plant Indigofera argentea

    PubMed Central

    Lafi, Feras F.; Alam, Intikhab; Geurts, Rene; Bisseling, Ton; Bajic, Vladimir B.

    2017-01-01

    ABSTRACT Enterobacter sp. Sa187 is a plant endophytic bacterium, isolated from root nodules of the desert plant Indigofera argentea, collected from the Jizan region of Saudi Arabia. Here, we report the genome sequence of Sa187, highlighting several genes involved in plant growth–promoting activity and environmental adaption. PMID:28209831

  8. 33 CFR 187.107 - What information must be made available to assist law enforcement officials and what information...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...) BOATING SAFETY VESSEL IDENTIFICATION SYSTEM Information to be Collected by Participating States § 187.107... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false What information must be made available to assist law enforcement officials and what information may be made available? 187.107...

  9. 33 CFR 187.107 - What information must be made available to assist law enforcement officials and what information...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...) BOATING SAFETY VESSEL IDENTIFICATION SYSTEM Information to be Collected by Participating States § 187.107... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false What information must be made available to assist law enforcement officials and what information may be made available? 187.107...

  10. 33 CFR 187.107 - What information must be made available to assist law enforcement officials and what information...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...) BOATING SAFETY VESSEL IDENTIFICATION SYSTEM Information to be Collected by Participating States § 187.107... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false What information must be made available to assist law enforcement officials and what information may be made available? 187.107...

  11. 33 CFR 187.107 - What information must be made available to assist law enforcement officials and what information...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...) BOATING SAFETY VESSEL IDENTIFICATION SYSTEM Information to be Collected by Participating States § 187.107... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false What information must be made available to assist law enforcement officials and what information may be made available? 187.107...

  12. 33 CFR 187.313 - Must a State honor a prior State title, Coast Guard documentation, and foreign registry?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... title, Coast Guard documentation, and foreign registry? 187.313 Section 187.313 Navigation and Navigable..., Coast Guard documentation, and foreign registry? (a) A State must honor a title issued by another State.... (c) A State must honor an authenticated copy of a foreign registry, or evidence of deletion from...

  13. 33 CFR 187.313 - Must a State honor a prior State title, Coast Guard documentation, and foreign registry?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... title, Coast Guard documentation, and foreign registry? 187.313 Section 187.313 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) BOATING SAFETY VESSEL IDENTIFICATION..., Coast Guard documentation, and foreign registry? (a) A State must honor a title issued by another...

  14. 33 CFR 187.313 - Must a State honor a prior State title, Coast Guard documentation, and foreign registry?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... title, Coast Guard documentation, and foreign registry? 187.313 Section 187.313 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) BOATING SAFETY VESSEL IDENTIFICATION..., Coast Guard documentation, and foreign registry? (a) A State must honor a title issued by another...

  15. 33 CFR 187.313 - Must a State honor a prior State title, Coast Guard documentation, and foreign registry?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... title, Coast Guard documentation, and foreign registry? 187.313 Section 187.313 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) BOATING SAFETY VESSEL IDENTIFICATION..., Coast Guard documentation, and foreign registry? (a) A State must honor a title issued by another...

  16. 33 CFR 187.313 - Must a State honor a prior State title, Coast Guard documentation, and foreign registry?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... title, Coast Guard documentation, and foreign registry? 187.313 Section 187.313 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) BOATING SAFETY VESSEL IDENTIFICATION..., Coast Guard documentation, and foreign registry? (a) A State must honor a title issued by another...

  17. 33 CFR 187.107 - What information must be made available to assist law enforcement officials and what information...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... available to assist law enforcement officials and what information may be made available? 187.107 Section... What information must be made available to assist law enforcement officials and what information may be... by law enforcement officials: (1) Vessel identifier(s), as required by § 187.9. (2) Notice of...

  18. Redox properties of mixed lutetium/yttrium nitride clusterfullerenes: endohedral Lu(x)Y(3-x)N@C80(I) (x = 0-3) compounds.

    PubMed

    Tarábek, Ján; Yang, Shangfeng; Dunsch, Lothar

    2009-05-11

    The redox behavior of mixed lutetium/yttrium nitride clusterfullerenes of the series Lu(x)Y(3-x)N@C(80)(I(h), x = 0-3) is studied for the first time by means of cyclic voltammetry, fast-scan cyclic voltammetry, square-wave voltammetry, and electron paramagnetic resonance (EPR) spectroelectrochemistry. A reversible single-electron-transfer process, which does not result in an EPR signal, is detected during the anodic oxidation sweep of cyclic voltammetry experiments performed at different temperatures (296 and 360 K). The cathodic reduction sweep reveals a rather complex response for all the four clusterfullerenes--with up to three irreversible reduction steps. By correlating the results of fast-scan and square-wave voltammetry and combining them with simulations of the voltammograms, we are able to propose a reduction mechanism for the Lu(x)Y(3-x)N@C(80)(I) (x = 0-3) fullerenes.

  19. Lutetium (177) PSMA radionuclide therapy for men with prostate cancer: a review of the current literature and discussion of practical aspects of therapy.

    PubMed

    Emmett, Louise; Willowson, Kathy; Violet, John; Shin, Jane; Blanksby, Ashley; Lee, Jonathan

    2017-03-01

    Prostate-specific membrane antigen (PSMA) is a receptor on the surface of prostate cancer cells that is revolutionising the way we image and treat men with prostate cancer. New small molecule peptides with high-binding affinity for the PSMA receptor have allowed high quality, highly specific PET imaging, in addition to the development of targeted radionuclide therapy for men with prostate cancer. This targeted therapy for prostate cancer has, to date, predominately used Lutetium 177 (Lu) labelled PSMA peptides. Early clinical studies evaluating the safety and efficacy of Lu PSMA therapy have demonstrated promising results with a significant proportion of men with metastatic prostate cancer, who have already failed other therapies, responding clinically to Lu PSMA. This review discusses the practical issues of administering Lu PSMA, and gives an overview of the findings from currently published trials in regards to treatment response rates, expected toxicities and safety.

  20. Fabrication and microstructure of cerium doped lutetium aluminum garnet (Ce:LuAG) transparent ceramics by solid-state reaction method

    SciTech Connect

    Li, Junlang; Xu, Jian; Shi, Ying; Qi, Hongfang; Xie, Jianjun; Lei, Fang

    2014-07-01

    Highlights: • We fabricate Ce doped lutetium aluminum garnet ceramics by solid-state method. • The raw materials include Lu{sub 2}O{sub 3} nanopowders synthesized by co-precipitation method. • The density of the transparent ceramics reach 99.7% of the theoretical value. • The optical transmittance of the bulk ceramic at 550 nm was 57.48%. • Some scattering centers decrease the optical characteristic of the ceramic. - Abstract: Polycrystalline Ce{sup 3+} doped lutetium aluminum garnet (Ce:LuAG) transparent ceramics fabricated by one step solid-state reaction method using synthetic nano-sized Lu{sub 2}O{sub 3}, commercial α-Al{sub 2}O{sub 3} and CeO{sub 2} powders were investigated in this paper. The green compacts shaped by the mixed powders were successfully densified into Ce:LuAG transparent ceramics after vacuum sintering at 1750 °C for 10 h. The in-line optical transmittance of the Ce:LuAG ceramic made by home-made Lu{sub 2}O{sub 3} powders could reach 57.48% at 550 nm, which was higher than that of the ceramic made by commercial Lu{sub 2}O{sub 3} powders (22.96%). The microstructure observation showed that light scattering centers caused by micro-pores, aluminum segregation and refraction index inhomogeneities induced the decrease of optical transparency of the Ce:LuAG ceramics, which should be removed and optimized in the future work.

  1. Production of chitinase from shellfish waste by Pseudomonas aeruginosa K-187.

    PubMed

    Wang, S L; Chiou, S H; Chang, W T

    1997-04-01

    The production of chitinolytic enzyme by Pseudomonas aeruginosa K-187, using shrimp and crab shell powder (SCSP) as the carbon source, was studied. It was observed that chemically treated SCSP induced a significant increase of enzyme production, as compared with untreated SCSP. Spent HCl and NaOH from the chitin production industry was used to process SCSP. Various strategies of SCSP processing are examined and compared in terms of chitinolytic enzyme production. A three-and-one-half-fold increase of enzyme production (0.68 U/ml to 2.4 U/ml) was attained using HCl/NaOH treated SCSP. The microorganism (K-187) was isolated from soil in Taiwan and has been characterized and reported in a previous paper.

  2. Osmium-187 enrichment in some plumes: Evidence for core-mantle interaction?

    USGS Publications Warehouse

    Walker, R.J.; Morgan, J.W.; Horan, M.F.

    1995-01-01

    Calculations with data for asteroidal cores indicate that Earth's outer core may have a rhenium/osmium ratio at least 20 percent greater than that of the chondritic upper mantle, potentially leading to an outer core with an osmium-187/osmium-188 ratio at least 8 percent greater than that of chondrites. Because of the much greater abundance of osmium in the outer core relative to the mantle, even a small addition of metal to a plume ascending from the D??? layer would transfer the enriched isotopic signature to the mixture. Sources of certain plume-derived systems seem to have osmium-187/osmium-188 ratios 5 to 20 percent greater than that for chondrites, consistent with the ascent of a plume from the core-mantle boundary.

  3. Osmium-187 Enrichment in Some Plumes: Evidence for Core-Mantle Interaction?

    NASA Astrophysics Data System (ADS)

    Walker, Richard J.; Morgan, John W.; Horan, Mary F.

    1995-08-01

    Calculations with data for asteroidal cores indicate that Earth's outer core may have a rhenium/osmium ratio at least 20 percent greater than that of the chondritic upper mantle, potentially leading to an outer core with an osmium-187/osmium-188 ratio at least 8 percent greater than that of chondrites. Because of the much greater abundance of osmium in the outer core relative to the mantle, even a small addition of metal to a plume ascending from the D'' layer would transfer the enriched isotopic signature to the mixture. Sources of certain plume-derived systems seem to have osmium-187/osmium-188 ratios 5 to 20 percent greater than that for chondrites, consistent with the ascent of a plume from the core-mantle boundary.

  4. Experimental identification of intruder bandheads in odd-mass {sup 187-193}Pb

    SciTech Connect

    Andreyev, A. N.; Huyse, M.; Van de Vel, K.; Van Duppen, P.; Cocks, J. F. C.; Dorvaux, O.; Greenlees, P.; Jones, P.; Julin, R.; Juutinen, S.; Helariutta, K.; Kettunen, H.; Kuusiniemi, P.; Leino, M.; Muikku, M.; Trzaska, W. H.; Eskola, K.; Wyss, R.

    1999-11-16

    Fine-structure {alpha}-decays of the odd mass {sup 191-197}Po identifying proton based intruder states in the daughter lead nuclei have been observed, leading to a systematics of intruder states in odd mass lead isotopes from {sup 197}Pb down to {sup 187}Pb. The interpretation of these states involves the coupling of the i{sub 13/2} or p{sub 3/2} odd neutron to the oblate deformed even lead core.

  5. Experimental Identification of Intruder Bandheads in Odd-Mass {sup 187-193}Pb

    SciTech Connect

    A.N. Andreyev; J.F.C. Cocks; O. Dorvaux; K. Eskola; P. Greenlees; P. Jones; R. Julin; S. Juutinen; K. Helariutta; M. Huyse; H. Kettunen; P. Kuusiniemi; M. Leino; M. Muikku; W.H. Trzaska; K. Van de Vel; P. Van Duppen; R. Wyss

    1999-12-31

    Fine-structure {alpha}-decays of the odd mass {sup 191-197}Po identifying proton based intruder states in the daughter lead nuclei have been observed, leading to a systematics of intruder states in odd mass lead isotopes from {sup 197}Pb down to {sup 187}Pb. The interpretation of these states involves the coupling of the i{sub 13/2} or p{sub 3/2} odd neutron to the oblate deformed even lead core.

  6. Spectroscopy of {sup 189,187}Pb from gamma-FMA coincidences

    SciTech Connect

    Janssens, R.V.F.; Davids, C.N.; Blumenthal, D.

    1995-08-01

    The very neutron-deficient Pb isotopes are of much current interest because they exhibit shape coexistence between a spherical groundstate and a deformed prolate excited configuration located very low in excitation energy. Last year the nucleus {sup 186}Pb was studied at the FMA in an FMA-{gamma}-{gamma} coincidence experiment. The purpose of the present measurement was to delineate, for the first time, the groundstate and near groundstate excitations in the odd Pb isotopes {sup 189,187}Pb in order to identify the orbitals which have an important role in driving the nuclear shape. The experiment was performed only very recently at the FMA with 10 Compton-suppressed Ge detectors from the Argonne Notre Dame BGO Gamma-Ray facility. {sup 187}Pb was studied with the {sup 155}Gd({sup 36}Ar,4n) reaction at 179 MeV, while {sup 189}Pb was reached with the {sup 158}Gd({sup 36}Ar,5n) reaction at the same beam energy. The analysis just began. It can already be stated that transitions in both Pb isotopes were identified and that it should be possible to establish level schemes. The presence of possible isomeric states in {sup 189}Pb will be checked in a follow-up experiment planned in Canberra. A similar measurement on {sup 187}Pb appears very difficult because of the very small cross section involved.

  7. 187Os-186Os and He Isotope Systematics of Iceland Picrites

    NASA Astrophysics Data System (ADS)

    Brandon, A. D.; Brandon, A. D.; Graham, D.; Gautason, B.

    2001-12-01

    Iceland is one of the longest-lived modern plumes, and seismic imaging supports a model where the roots of this plume are at the base of the lower mantle. Hence, Os isotopic data for lavas from this plume are ideal for further testing the role of core-mantle chemical exchange at the site of plume generation in the lower mantle, and for addressing the origin of Os-He isotopic variation in plumes. Recent work has shown that lavas from some plume systems (Hawaii, Noril'sk-Siberia, Gorgona) show coupled enrichments in 186Os/188Os and 187Os/188Os, not observed in upper mantle materials including abyssal peridotites. Picrites from Hawaii display a positive correlation between 186Os/188Os and He isotopes (R/Ra), where range in 186Os/188Os of 0.119834+/-28 to 0.1198475+/-29 and corresponding R/Ra from +7 to +25. These systematics are consistent with a lower mantle source for the radiogenic 186Os signal in the Hawaiian plume. The coupled Os enrichments in these plumes has been attributed to core-mantle chemical exchange, consistent with generation of the Hawaiian plume at the base of the lower mantle in D". Other potentially viable models await additional scrutiny. New He isotope and high precision 186Os/188Os and 187Os/188Os measurements for Iceland picrites show unique systematics compared to Hawaii. These picrites have 187Os/188Os ranging from 0.1297 to 0.1381 and R/Ra of +9 to +18, with generally higher R/Ra correlating with higher 187Os/188Os. Unlike the Hawaiian picrites from Hualalai and Loihi, which have coupled enrichments in 186Os/188Os and 187Os/188Os, the Iceland picrites show no enrichment 186Os/188Os - 0.1198363+/-28 (2s, n=14). Such Os-He isotopic variations require one end-member source that has high R/Ra, coupled with a long term elevated Re/Os and Pt/Os similar to that of the upper mantle. These systematics are inconsistent with either known upper mantle materials or those purported for ancient recycled slabs and may be a previously unidentified component

  8. S187 : SCP 1 (H2): A Curved Molecular Hydrogen Outflow

    NASA Astrophysics Data System (ADS)

    Salas, Luis; Cruz-González, Irene; Porras, Alicia

    1998-06-01

    We imaged in the near-infrared the region associated with IRAS 01202+6133, which lies to the southeast of the Sharpless H II region S187, designated as S187 IR. We report the discovery of a curved molecular hydrogen outflow that extends over a region of 76" (0.38 pc at D = 1 kpc), identified as S187:SCP 1 (H2). The outflow changes direction by more than 90° in a continuous way and is the most dramatic example of direction variability in a jet source known to date. The outflow-driving source is probably an extreme T Tauri star identified as NIRS 1 located at the apex of the curved structure. The curved jetlike structure shows a sinuous chain of several emission knots located along an extended H2 nebulosity. The similarity with the properties of optical Herbig-Haro jets observed in the near-IR allows us to conclude that S187:SCP 1 (H2) is a Herbig-Haro object. We discuss whether the supersonic side-wind model proposed by Cantó & Raga provides the best physical scenario for the curved outflow seen in S187 IR. According to this model, the initial angle of the jet is nearly opposite to the wind direction, and the wind action turns the jet through 150°, resulting in a minimum radius of curvature of 0.14 pc. Assuming typical values for T Tauri stars in molecular environments (Ṁ=10-7 M⊙ yr-1, vjet = 150 km s-1, vsound ≡ s = 10 km s-1, na = 104 cm-3), the required wind velocity is 10 km s-1, which is of the same order of magnitude as the typical velocities of T Tauri stars relative to their surrounding molecular clouds. Furthermore, the predicted position of the stagnation point, where the hydrostatic pressure in the jet equals the ram pressure of the wind, coincides with an observed H2 emission maximum along the curved part of the outflow. The predicted curve extends to a bow-shock-like H2 nebulosity located 2' (0.46 pc at D = 1 kpc) away from the curved outflow. Based on observations obtained at the Observatorio Astronómico Nacional at San Pedro Mártir, B

  9. Correlation Between IL-10 and microRNA-187 Expression in Epileptic Rat Hippocampus and Patients with Temporal Lobe Epilepsy

    PubMed Central

    Alsharafi, Walid A.; Xiao, Bo; Abuhamed, Mutasem M.; Bi, Fang-Fang; Luo, Zhao-Hui

    2015-01-01

    Accumulating evidence is emerging that microRNAs (miRNAs) are key regulators in controlling neuroinflammatory responses that are known to play a potential role in the pathogenesis of temporal lobe epilepsy (TLE). The aim of the present study was to investigate the dynamic expression pattern of interleukin (IL)-10 as an anti-inflammatory cytokine and miR-187 as a post-transcriptional inflammation-related miRNA in the hippocampus of a rat model of status epilepticus (SE) and patients with TLE. We performed a real-time quantitative PCR and western blot on rat hippocampus 2 h, 7 days, 21 days and 60 days following pilocarpine-induced SE, and on hippocampus obtained from TLE patients and normal controls. To detect the relationship between IL-10 and miR-187 on neurons, lipopolysaccharide (LPS) and IL-10-stimulated neurons were performed. Furthermore, we identified the effect of antagonizing miR-187 by its antagomir on IL-10 secretion. Here, we reported that IL-10 secretion and miR-187 expression levels are inversely correlated after SE. In patients with TLE, the expression of IL-10 was also significantly upregulated, whereas miR-187 expression was significantly downregulated. Moreover, miR-187 expression was significantly reduced following IL-10 stimulation in an IL-10–dependent manner. On the other hand, antagonizing miR-187 promoted the production of IL-10 in hippocampal tissues of rat model of SE. Our findings demonstrate a critical role of miR-187 in the physiological regulation of IL-10 anti-inflammatory responses and elucidate the role of neuroinflammation in the pathogenesis of TLE. Therefore, modulation of the IL-10 / miR-187 axis may be a new therapeutic approach for TLE. PMID:26696826

  10. The Late Eocene 187Os / 188Os excursion: Chemostratigraphy, cosmic dust flux and the Early Oligocene glaciation

    NASA Astrophysics Data System (ADS)

    Dalai, Tarun K.; Ravizza, Gregory E.; Peucker-Ehrenbrink, B.

    2006-01-01

    High resolution records (ca. 100 kyr) of Os isotope composition ( 187Os / 188Os) in bulk sediments from two tropical Pacific sites (ODP Sites 1218 and 1219) capture the complete Late Eocene 187Os / 188Os excursion and confirm that the Late Eocene 187Os / 188Os minimum, earlier reported by Ravizza and Peucker-Ehrenbrink [Earth Planet. Sci. Lett. 210 (2003) 151-165], is a global feature. Using the astronomically tuned age models available for these sites, it is suggested that the Late Eocene 187Os / 188Os minimum can be placed at 34.5 ± 0.1 Ma in the marine records. In addition, two other distinct features of the 187Os / 188Os excursion that are correlatable among sections are proposed as chemostratigraphic markers which can serve as age control points with a precision of ca. ± 0.1 Myr. We propose a speculative hypothesis that higher cosmic dust flux in the Late Eocene may have contributed to global cooling and Early Oligocene glaciation (Oi-1) by supplying bio-essential trace elements to the oceans and thereby resulting in higher ocean productivity, enhanced burial of organic carbon and draw down of atmospheric CO 2. To determine if the hypothesis that enhanced cosmic dust flux in the Late Eocene was a cause for the 187Os / 188Os excursion can be tested by using the paired bulk sediment and leachate Os isotope composition; 187Os / 188Os were also measured in sediment leachates. Results of analyses of leachates are inconsistent between the south Atlantic and the Pacific sites, and therefore do not yield a robust test of this hypothesis. Comparison of 187Os / 188Os records with high resolution benthic foraminiferal δ18O records across the Eocene-Oligocene transition suggests that 187Os flux to the oceans decreased during cooling and ice growth leading to the Oi-1 glaciation, whereas subsequent decay of ice-sheets and deglacial weathering drove seawater 187Os / 188Os to higher values. Although the precise timing and magnitude of these changes in weathering fluxes

  11. Preliminary results from the chemistry of micrometeoroid experiment (AO 187-1)

    NASA Technical Reports Server (NTRS)

    Horz, Friedrich; Bernhard, R. P.; See, Thomas H.; Warren, J.; Brownlee, Don E.; Laurance, M.

    1991-01-01

    The purpose of experiment AO 187-1 was to expose high purity substrates of suitable cratering properties to obtain detailed crater statistics that may be converted into projectile masses and fluxes and to chemically characterize as many impactors as possible. The latter information would hopefully reveal distinct classes of natural and man-made particles in low-Earth orbit. It was found that crater that yield residues show that natural and man-made impactors may be differentiated and that diversity exists within each group. 'Chondritic' compositions dominate among natural particles, yet some craters contain unmelted fragments of minerals (Olivine and pyroxene).

  12. Inelastic scattering of 45-keV neutrons by {sup 187}Os

    SciTech Connect

    Litvinskii, L.L.; Zhigalov, Ya.A.; Libman, V.A.; Murzin, A.V.; Shkarupa, A.M.

    1995-02-01

    The cross sections of elastic and inelastic scattering of 45-keV neutrons by {sup 187}Os are measured by the technique of filtered neutron beams at the Kiev VVR-M reactor and are found to be {sigma}{sub e1} = 11.90 {+-} 0.50 b and {sigma}{sub inel} = 1.51 {+-} 0.45 b, respectively. These results confirm the existence of a nonstatistical enhancement of the inelastic-scattering channel due to a noticeable contribution of a preequilibrium state involving two particles and a hole. 8 refs., 1 fig.

  13. LDEF (Prelaunch), AO187-01 : The Chemistry of Micrometeoroids, Tray A03

    NASA Technical Reports Server (NTRS)

    1984-01-01

    LDEF (Prelaunch), AO187-01 : The Chemistry of Micrometeoroids, Tray A03 The prelaunch photograph shows the two (2) clam shell type canisters in their closed position. The canister shells are made of aluminum sheet material with end caps of diecast aluminum. The baseplate and support structure are fabricated from 6000 series aluminum. Fasteners are non-magnetic stainless steel. The electrical box and the stainless steel tubing located on the baseplate protect the drive system wiring. The experiment contains a timing mechanism that provides the intelligence to open the canisters after the Orbiter has departed the area and any initial outgassing or offgassing has occurred.

  14. Construction of a chimeric lysin Ply187N-V12C with extended lytic activity against staphylococci and streptococci

    PubMed Central

    Dong, Qiuhua; Wang, Jing; Yang, Hang; Wei, Cuihua; Yu, Junping; Zhang, Yun; Huang, Yanling; Zhang, Xian-En; Wei, Hongping

    2015-01-01

    Developing chimeric lysins with a wide lytic spectrum would be important for treating some infections caused by multiple pathogenic bacteria. In the present work, a novel chimeric lysin (Ply187N-V12C) was constructed by fusing the catalytic domain (Ply187N) of the bacteriophage lysin Ply187 with the cell binding domain (146-314aa, V12C) of the lysin PlyV12. The results showed that the chimeric lysin Ply187N-V12C had not only lytic activity similar to Ply187N against staphylococcal strains but also extended its lytic activity to streptococci and enterococci, such as Streptococcus dysgalactiae, Streptococcus agalactiae, Streptococcus pyogenes, Enterococcus faecium and Enterococcus faecalis, which Ply187N could not lyse. Our work demonstrated that generating novel chimeric lysins with an extended lytic spectrum was feasible through fusing a catalytic domain with a cell-binding domain from lysins with lytic spectra across multiple genera. PMID:25219798

  15. The Status of the MARE Experiment with 187Re and 163Ho Isotopes

    NASA Astrophysics Data System (ADS)

    Ferri, E.; Bagliani, D.; Biasotti, M.; Ceruti, G.; Corsini, D.; Faverzani, M.; Gatti, F.; Giachero, A.; Gotti, C.; Kilbourne, C.; Kling, A.; Maino, M.; Manfrinetti, P.; Nucciotti, A.; Pessina, G.; Pizzigoni, G.; Gomes, M. Ribeiro; Sisti, M.

    Neutrino oscillation experiments have proved that neutrinos are massive particles but the assessment of their absolute mass scale is still an outstanding challenge in today particle physics and cosmology. The laboratory experiments dedicated to effective electron-neutrino mass determination are the ones based on the study of single beta decay or electron capture (EC) decay. Exploiting only on energy-momentum conservation, this kinematic measurement is the only one which permits to estimate neutrino masses without theoretical assumptions on neutrino nature and it is truly model-independent. To date the most competitive isotopes for a calorimetric measurement of the neutrino mass are 187Re and 163Ho. While the first decays beta, the latter decays via electron capture, and both have a Q-value around 2.5 keV. The measurement of 163Ho EC is an appealing alternative to the 187Re beta decay measurement because few nuclei are needed and it is a self-calibrating measurement. In this context the MARE project, based on rhenium thermal detectors has been born. We report here the status of MARE in Milan with Rhenium and the activity concerning the production of radioactive 163Ho isotope in the framework of MARE.

  16. LDEF (Postflight), AO187-01 : The Chemistry of Micrometeoroids, Tray A03

    NASA Technical Reports Server (NTRS)

    1990-01-01

    LDEF (Postflight), AO187-01 : The Chemistry of Micrometeoroids, Tray A03 EL-1994-00266 LDEF (Postflight), AO187-01 : The Chemistry of Micrometeoroids, Tray A03 The experiment is shown in the postflight configuration before closing the canisters with ground support equipment that bypassed the experiments onboard electronics circuitry. Three full panels and approximately 3/4th of the other panel are covered with gold foil (>99.99 percent pure). The remaining area on the fourth panel is covered with strips of other detector materials: zirconium, beryllium, titanium, platium, aluminum, carbon, Kapton, polyethylene and TEFLON®. A brown stain is visible on the experiment tray flanges, however, most of the stains observed in the flight photograph are obscured by reflected light. All materials remain intact with no visual evidence of damage to the experiment. The reflection of a video camera on a tripod and light sources can be seen on the gold foil covered panels. The experiment canisters are shown after being closed by using the experiments ground support equipment. The stain buildup can be clearly seen at the vertical center of the right tray flange. The clean area was located under the experiment tray clamp block and was not exposed to the staining medium. The stain also coats other areas that were exposed during the mission but are not as noticeable. The experiment hardware seems to be intact and have no damage.

  17. LDEF (Flight), AO187-01 : The Chemistry of Micrometeoroids, Tray A03

    NASA Technical Reports Server (NTRS)

    1990-01-01

    LDEF (Flight), AO187-01 : The Chemistry of Micrometeoroids, Tray A03 EL-1994-00680 LDEF (Flight), AO187-01 : The Chemistry of Micrometeoroids, Tray A03 The flight photograph was taken with the LDEF on the Orbiter's RMS arm prior to berthing the spacecraft in the cargo bay. The canisters are in their open condition (they were expected to open about two (2) weeks after launch and close about eleven (11) months into the mission) with three (3) full panels and 3/4th of the fourth panel covered with a highly reflective gold foil (>99.99 percent pure).The remaining area is covered with strips of other detector materials: zirconium, beryllium, titanium, platium, aluminum, carbon, Kapton, polyethylene and TEFLON®. The exposed fasteners are non-magnetic stainless steel. All of the exposed materials seem to be secure and no damage is evident. The contamination stain that has changed the white paint dot on the tray clamp blocks to brown also coats the tray flanges and the aluminum canister hardware. The end support beam scuff plate in the photograph was a bright yellow prior to launch but is a much darker, mustard yellow after the space exposure.

  18. O2 absorption cross sections /187-225 nm/ from stratospheric solar flux measurements

    NASA Astrophysics Data System (ADS)

    Herman, J. R.; Mentall, J. E.

    1982-10-01

    The absorption cross sections of molecular oxygen are calculated in the wavelength range from 187 to 230 nm from solar flux measurements obtained within the stratosphere. Within the Herzberg continuum wavelength region the molecular oxygen cross sections are found to be about 30% smaller than the laboratory results of Shardanand and Rao (1977) from 200 to 210 nm and about 50% smaller than those of Hasson and Nicholls (1971). At wavelengths longer than 210 nm the cross sections agree with those of Shardanand and Rao. The effective absorption cross sections of O2 in the Schumann-Runge band region from 187 to 200 nm are calculated and compared to the empirical fit given by Allen and Frederick (1982). The calculated cross sections indicate that the transmissivity of the atmosphere may be underestimated by the use of the Allen and Frederic cross sections between 195 and 200 nm. The ozone column content between 30 and 40 km and the relative ozone cross sections are determined from the same solar flux data set.

  19. O2 absorption cross sections /187-225 nm/ from stratospheric solar flux measurements

    NASA Technical Reports Server (NTRS)

    Herman, J. R.; Mentall, J. E.

    1982-01-01

    The absorption cross sections of molecular oxygen are calculated in the wavelength range from 187 to 230 nm from solar flux measurements obtained within the stratosphere. Within the Herzberg continuum wavelength region the molecular oxygen cross sections are found to be about 30% smaller than the laboratory results of Shardanand and Rao (1977) from 200 to 210 nm and about 50% smaller than those of Hasson and Nicholls (1971). At wavelengths longer than 210 nm the cross sections agree with those of Shardanand and Rao. The effective absorption cross sections of O2 in the Schumann-Runge band region from 187 to 200 nm are calculated and compared to the empirical fit given by Allen and Frederick (1982). The calculated cross sections indicate that the transmissivity of the atmosphere may be underestimated by the use of the Allen and Frederic cross sections between 195 and 200 nm. The ozone column content between 30 and 40 km and the relative ozone cross sections are determined from the same solar flux data set.

  20. Behavior of Intruder Based States in Light Bi and Tl Isotopes: The Study of 187Bi Alpha Decay

    SciTech Connect

    Batchelder, J.C.; Bingham, C.R.; Brown, L.T.; Conticchio, L.F.; Davids, C.N.; DeCoster, C.; Decroix, B.; Heyde, K.; Irvine, R.J.; Seweryniak, D.; Toth, K.S.; Walters, W.B.; Wauters, J.; Wood, J.L.; Zganjar, E.F.

    1998-11-13

    The excitation energies of the single-particle normal and intruder levels in both `83T1 and 187Bi were measured for the first time via the ct decay of 187Bi produced in the 97Mo(92Mo,pn) 187Bi reaction. The previously unobserved 187Bi ground state (kw) to 183T1 ground state (s1/2) a transition was identified establishing the 187Bi intruder state excitation energy to be 112(21) keV, 70 keV less than that of the same level in 189Bi.

  1. Ultraviolet Spectroscopy of Metal-Poor Stars: New Detections of Phosphorus, Germanium, Arsenic, Selenium, Cadmium, Tellurium, Lutetium, Osmium, Iridium, Platinum, Gold, and More!

    NASA Astrophysics Data System (ADS)

    Roederer, Ian U.

    2015-01-01

    Ultraviolet spectroscopy with HST/STIS provides a 30% increase in the number of elements that can be detected in metal-poor stars. Although nearly every element from hydrogen through bismuth is probably present in most metal-poor stars, not all elements can be detected. The resonance lines of the dominant species of some elements are only found in the UV in late-type stars. The chemical compositions of these stars reflect the history of stellar nucleosynthesis from the first stars to today. Here, I present a summary of recent work that has expanded the chemical inventory in metal-poor stars using UV spectroscopy conducted using HST/STIS. The highlights include new detections of phosphorus, germanium, arsenic, selenium, cadmium, tellurium, lutetium, osmium, iridium, platinum, and gold in metal-poor stars. These detections reveal new insights into stellar nucleosynthesis in the earliest generations of massive stars, provide new constraints on the r-process, and open new channels for chemically-tagging stars that have assembled to form the Milky Way stellar halo.

  2. Development of a new bombesin analog radiolabeled with lutetium-177: in vivo evaluation of the biological properties in Balb-C mice.

    PubMed

    Pujatti, P B; Santos, J S; Massicano, A V F; Mengatti, J; De Araújo, E B

    2010-05-10

    In this work we describe the first results of radiolabeling with lutetium-177 ((177)Lu) and in vivo biodistribution and pharmacokinetics studies in normal Balb-c mice of a new bombesin analog (BEFG2)--DOTA-Phe-X-BBN(6-14), where X is a spacer of two aminoacids. Bombesin (BBN) is an amphibian analog of human gastrin releasing peptide (GRP). Development of radiolabeled BBN derivatives as agents for diagnostic imaging and systemic radiotherapy has increased considerable because of the observation that GRP receptors (GRPr) are over-expressed in a variety of human tumor cells, such as prostate tumor cells. (177)Lu-labeled peptides are attractive due to the excellent radiophysical properties and commercial availability of the radiometal. BEFG2 was successfully labeled with high yield and kept stable for more than 96 hours at 2-8 degrees C and 1 hour in human plasma. Data analysis obtained from the in vivo studies showed that the amount of BEFG2 present in plasma decreased rapidly and became almost undetectable at 60 min p.i., indicating rapid peptide excretion, which is performed mainly by renal pathway. In addition, biodistribution and single photon emission tomography showed low abdominal accumulation of (177)Lu-DOTA- Phe-X-BBN(6-14), indicating that this analog is a potential candidate for tumors target therapy.

  3. Electron microscopy studies of lutetium doped erbium silicide (Er{sub 0.9}Lu{sub 0.1}){sub 5}Si{sub 4}

    SciTech Connect

    Cao, Q. Chumbley, L.S.

    2011-08-15

    Examination of bulk microstructures of lutetium doped erbium silicide (Er{sub 0.9}Lu{sub 0.1}){sub 5}Si{sub 4} (space group: Pnma) using scanning and transmission electron microscopy (SEM, TEM) reveals the existence of thin plates of a hexagonal phase (space group: P6{sub 3}/mcm) where the stoichiometric ratio in moles between the rare earths and Si is 5 to 3, i. e the 5:3 phase. The orientation relationship between the matrix and the plates was determined as [010]{sub m} {approx} -parallel [-1010]{sub p.} This observation adds credence to the assumption that all linear features noted in alloys of the rare-earth intermetallic family R{sub 5}(Si{sub x}Ge{sub 1-x}){sub 4} are of the stoichiometric ratio 5:3 and possess a common orientation relationship with the parent 5:4 alloys. - Highlights: {yields} The linear features observed in the (Er{sub 0.9}Lu{sub 0.1}){sub 5}Si{sub 4} sample are hexagonal 5:3 plates. {yields} Thickness of 5:3 plates in 5:4 alloys made by tri-arc pulling is greater than made by arc-melting. {yields} The orientation relationship between 5:3 plates and the matrix is [010]{sub m} {approx} ||[-1010]{sub p}.

  4. Indirect Production of No Carrier Added (NCA) (177)Lu from Irradiation of Enriched (176)Yb: Options for Ytterbium/Lutetium Separation.

    PubMed

    Dash, Ashutosh; Chakravarty, Rubel; Knapp, Furn F Russ; Pillai, Ambikalmajan M R

    2015-01-01

    This article presents a concise review of the production of no-carrier-added (NCA) (177)Lu by the 'indirect' route by irradiating ytterbium-176 ((176)Yb)-enriched targets. The success of this production method depends on the ability to separate the microscopic amounts of NCA (177)Lu from bulk irradiated ytterbium targets. The presence of Yb(+3) from the target in the final processed (177)Lu will adversely affect the quality of (177)Lu by decreasing the specific activity and competing with Lu(+3) complexation since ytterbium will follow the same coordination chemistry. Ytterbium and lutetium are adjacent members of the lanthanide family with very similar chemical properties which makes the separation of one from the other a challenging task. This review provides a summary of the methods developed for the separation and purification of NCA (177)Lu from neutron irradiated (176)Yb-enriched targets, a critical assessment of recent developments and a discussion of the current status of this (177)Lu production method.

  5. Microbial communities in recent and 10 - 28 Ma ocean floor basalt (ODP Leg 187)

    NASA Astrophysics Data System (ADS)

    Lysnes, K.; Steinsbu, B. O.; Einen, J.; Thorseth, I. H.; Pedersen, R. B.; Torsvik, T.

    2003-04-01

    Previous studies have shown that microbial communities are harboring ocean crust basalt (e.g., Thorseth et al. 1995). The non-hydrothermal regions of ocean ridges are largely unstudied with respect to microbial diversity and physiology. In the present study, the microbial communities resident in samples of recent (<1 Ma) seafloor basalt collected from the axes of the Mohns, Knipovich, and Kolbeinsey Ridges in the Arctic Ocean and in 10 to 28 Ma core samples from the northern flank of the Southeast Indian Ridge (ODP Leg 187) were investigated. The primary objective was to study the microbial diversity and to compare the endolithic microbial communities in seafloor samples (Arctic Ridges) with subsurface samples (ODP Leg 187) by molecular biology techniques. To monitor possible contamination samples of sediment and seawater, treated in the same manner as the basalt samples, served as controls. Polymerase chain reaction -- denaturing gradient gel electrophoresis (PCR -- DGGE) were used to amplify fragments of 16S rRNA genes and to separate individual DNA sequences, corresponding to different species and strains of Bacteria and Archaea in the samples. Relative similarity indices were calculated from DGGE banding patterns using Jaccard's algorithm, and species richness was estimated using Shannon's index. Furthermore, individual DNA bands were excised from the gel and sequenced to evaluate the phylogenetic affiliation of the endolithic microbes. Shannon indices show that the species richness of microbial communities in basalt is higher for seafloor samples (Arctic Ridges) than for subsurface samples (Southeast Indian Ridge). The microbial population in the Arctic Ridge basalt samples affiliates with ten major lineages of the domain Bacteria and 1 major lineage of Archaea. Bacteria in the ODP Leg 187 basalt samples affiliate with six major lineages of the domain Bacteria, whereas no archaeal sequences were retrieved from these samples. Many sequences from both areas

  6. Nanoscale variations in 187Os isotopic composition and HSE systematics in a Bultfontein peridotite

    NASA Astrophysics Data System (ADS)

    Wainwright, A. N.; Luguet, A.; Schreiber, A.; Fonseca, R. O. C.; Nowell, G. M.; Lorand, J.-P.; Wirth, R.; Janney, P. E.

    2016-08-01

    Understanding the mineralogical controls on radiogenic chronometers is a fundamental aspect of all geochronological tools. As with other common dating tools, it has become increasingly clear that the Re-Os system can be impacted by multiple mineral formation events. The accessory and micrometric nature of the Re-Os-bearing minerals has made assessing this influence complex. This is especially evident in cratonic peridotites, where long residence times and multiple metasomatic events have created a complex melting and re-enrichment history. Here we investigate a harzburgitic peridotite from the Bultfontein kimberlite (South Africa) which contains sub-micron Pt-Fe-alloy inclusions within base metal sulphides (BMS). Through the combination of the focused ion beam lift-out technique and low blank mass spectrometry we were able to remove and analyse the Pt-Fe-alloy inclusions for their Re-Os composition and highly siderophile element (HSE) systematics. Six repeats of the whole-rock yield 187Os/188Os compositions of 0.10893-0.10965, which correspond to Re depletion model ages (TRD) of 2.69-2.79 Ga. The Os, Ir and Pt concentrations are slightly variable across the different digestions, whilst Pd and Re remain constant. The resulting HSE pattern is typical of cratonic peridotites displaying depleted Pt and Pd. The Pt-Fe-alloys have PUM-like 187Os/188Os compositions of 0.1294 ± 24 (2-s.d.) and 0.1342 ± 38, and exhibit a saw-tooth HSE pattern with enriched Re and Pt. In contrast, their BMS hosts have unradiogenic 187Os/188Os of 0.1084 ± 6 and 0.1066 ± 3, with TRD ages of 2.86 and 3.09 Ga, similar to the whole-rock systematics. The metasomatic origin of the BMS is supported by (i) the highly depleted nature of the mantle peridotite and (ii) their Ni-rich sulphide assemblage. Occurrence of Pt-Fe-alloys as inclusions within BMS grains demonstrates the genetic link between the BMS and Pt-Fe-alloys and argues for formation during a single but continuous event of silicate melt

  7. Thermal neutron radiative capture cross-section of 186W(n, γ)187W reaction

    NASA Astrophysics Data System (ADS)

    Tan, V. H.; Son, P. N.

    2016-06-01

    The thermal neutron radiative capture cross section for 186W(n, γ)187W reaction was measured by the activation method using the filtered neutron beam at the Dalat research reactor. An optimal composition of Si and Bi, in single crystal form, has been used as neutron filters to create the high-purity filtered neutron beam with Cadmium ratio of Rcd = 420 and peak energy En = 0.025 eV. The induced activities in the irradiated samples were measured by a high resolution HPGe digital gamma-ray spectrometer. The present result of cross section has been determined relatively to the reference value of the standard reaction 197Au(n, γ)198Au. The necessary correction factors for gamma-ray true coincidence summing, and thermal neutron self-shielding effects were taken into account in this experiment by Monte Carlo simulations.

  8. The Absolute Mass of Neutrino and the First Unique Forbidden β-DECAY of 187Re

    NASA Astrophysics Data System (ADS)

    Dvornický, Rastislav; Šimkovic, Fedor; Muto, Kazuo

    2011-10-01

    The planned rhenium β-decay experiment MARE might probe the absolute mass scale of neutrinos with the same sensitivity as the tritium β-decay experiment KATRIN, which will start data taking in 2011 and will proceed for five years. We present the energy distribution of emitted electrons for the first unique forbidden β-decay of 187Re. It is found that the p-wave emission of electron dominates over the s-wave. By assuming mixing of three neutrinos the Kurie function for the rhenium β-decay is derived. It is shown that the Kurie plot near the endpoint is within a good accuracy linear in the limit of massless neutrinos like the Kurie plot of the superallowed βof 3H.

  9. Absolute mass of neutrinos and the first unique forbidden β decay of Re187

    NASA Astrophysics Data System (ADS)

    Dvornický, Rastislav; Muto, Kazuo; Šimkovic, Fedor; Faessler, Amand

    2011-04-01

    The planned rhenium β-decay experiment, called the “Microcalorimeter Arrays for a Rhenium Experiment” (MARE), might probe the absolute mass scale of neutrinos with the same sensitivity as the Karlsruhe tritium neutrino mass (KATRIN) experiment, which will take commissioning data in 2011 and will proceed for 5 years. We present the energy distribution of emitted electrons for the first unique forbidden β decay of Re187. It is found that the p-wave emission of electron dominates over the s wave. By assuming mixing of three neutrinos, the Kurie function for the rhenium β decay is derived. It is shown that the Kurie plot near the end point is within a good accuracy linear in the limit of massless neutrinos like the Kurie plot of the superallowed β decay of H3.

  10. Absolute mass of neutrinos and the first unique forbidden {beta} decay of {sup 187}Re

    SciTech Connect

    Dvornicky, Rastislav; Simkovic, Fedor; Muto, Kazuo; Faessler, Amand

    2011-04-15

    The planned rhenium {beta}-decay experiment, called the ''Microcalorimeter Arrays for a Rhenium Experiment'' (MARE), might probe the absolute mass scale of neutrinos with the same sensitivity as the Karlsruhe tritium neutrino mass (KATRIN) experiment, which will take commissioning data in 2011 and will proceed for 5 years. We present the energy distribution of emitted electrons for the first unique forbidden {beta} decay of {sup 187}Re. It is found that the p-wave emission of electron dominates over the s wave. By assuming mixing of three neutrinos, the Kurie function for the rhenium {beta} decay is derived. It is shown that the Kurie plot near the end point is within a good accuracy linear in the limit of massless neutrinos like the Kurie plot of the superallowed {beta} decay of {sup 3}H.

  11. Structure and genetics of the O-antigens of Escherichia coli O182-O187.

    PubMed

    Senchenkova, Sof'ya N; Guo, Xi; Naumenko, Olesya I; Shashkov, Alexander S; Perepelov, Andrei V; Liu, Bin; Knirel, Yuriy A

    2016-11-29

    O-polysaccharides (OPSs) were obtained by mild acid degradation of the lipopolysaccharides of Escherichia coli O182-O187, and their structures were established by sugar analysis, Smith degradation, and (1)H and (13)C NMR spectroscopy. In addition to the monosaccharides that occur often in E. coli OPSs (d-Glc, d-Gal, d-Man, d-GlcNAc, d-GalNAc, d-GlcA, l-Fuc, d-Rib), a number of less common components were identified as the OPS constituents, including 2-acetamido-2-deoxy-l-quinovose and 4-deoxy-4-[(S)-3-hydroxybutanoyl-l-alanyl]-d-quinovose (O186), 3-acetamido-3-deoxy-d-fucose (O187), 3-deoxy-3-[(R)-3-hydroxybutanoyl]-d-fucose (O184), and 2,3-diacetamido-2,3-dideoxy-l-rhamnose (O182). The OPS structures of E. coli O183 and O182 are identical to those of the OPS of Shigella boydii type 10 and the capsular polysaccharide of E. coli K48, respectively. The OPSs of E. coli O186 and O123 are closely related differing in the presence of a Glc residue in the former in place of a GlcNAc residue in the latter. The O-antigen gene clusters of the bacteria studied were analyzed and their contents were found to be consistent with the OPS structures. Predicted glycosyltransferases encoded in the gene clusters were tentatively assigned to glycosidic linkages based on similarities to sequences of other E. coli O-serogroups available from GenBank and taking into account the OPS structures established.

  12. Thromboembolic disease due to thermolabile conformational changes of antithrombin Rouen-VI (187 Asn-->Asp)

    PubMed

    Bruce, D; Perry, D J; Borg, J Y; Carrell, R W; Wardell, M R

    1994-12-01

    A new variant of antithrombin (Rouen-VI, 187 Asn-->Asp) with increased heparin affinity was shown to have normal inhibitory activity which decreased slowly at 4 degrees C and rapidly at 41 degrees C. On electrophoresis the freshly isolated variant had an anodal shift relative to native antithrombin due to the mutation. A further anodal transition occurred after either prolonged storage at 4 degrees C or incubation at 41 degrees C due to the formation of a new inactive uncleaved component with properties characteristic of L-form (latent) antithrombin. At the same time, polymerization also occurred with a predominance of di-, tri-, and tetra-mers. These findings fit with the observed mutation of the conserved asparagine (187) in the F-helix destabilizing the underlying A-sheet of the molecule. Evidence of A-sheet perturbation is provided by the increased rate of peptide insertion into the A-sheet and by the decreased vulnerability of the reactive loop to proteolysis. The spontaneous formation of both L-antithrombin and polymers is consistent with our crystal structure of intact antithrombin where L-form and active antithrombin are linked together as dimers. The nature of this linkage favors a mechanism of polymerization whereby the opening of the A-sheet, to give incorporation of the reactive center loop, is accompanied by the bonding of the loop of one molecule to the C-sheet of the next. The accelerated lability of antithrombin Rouen-VI at 41 versus 37 degrees C provides an explanation for the clinical observation that episodes of thrombosis were preceded by unrelated pyrexias.

  13. Keggin polyoxoanion supported organic-inorganic trinuclear lutetium cluster, {Na(H2O)3[Lu(pydc)(H2O)3]3}[SiW12O40]·26.5H2O.

    PubMed

    Li, Suzhi; Zhang, Dongdi; Guo, Yuan Yuan; Ma, Pengtao; Qiu, Xiaoyang; Wang, Jingping; Niu, Jingyang

    2012-09-07

    A novel strawberry-like organic-inorganic hybrid, {Na(H(2)O)(3)[Lu(pydc)(H(2)O)(3)](3)}[SiW(12)O(40)]·26.5H(2)O (H(2)pydc = pyridine-2,6-dicarboxylate) containing an intriguing trinuclear lutetium cluster {Na(H(2)O)(3)[Lu(pydc)(H(2)O)(3)](3)}(4+) has been synthesized and its luminescent properties, IR, UV, TG, PXRD analyses and single crystal X-ray diffraction were investigated.

  14. Lutetium oxyorthosilicate (LSO) intrinsic activity correction and minimal detectable target activity study for SPECT imaging with a LSO-based animal PET scanner.

    PubMed

    Yao, Rutao; Ma, Tianyu; Shao, Yiping

    2008-08-21

    This work is part of a feasibility study to develop SPECT imaging capability on a lutetium oxyorthosilicate (LSO) based animal PET system. The SPECT acquisition was enabled by inserting a collimator assembly inside the detector ring and acquiring data in singles mode. The same LSO detectors were used for both PET and SPECT imaging. The intrinsic radioactivity of (176)Lu in the LSO crystals, however, contaminates the SPECT data, and can generate image artifacts and introduce quantification error. The objectives of this study were to evaluate the effectiveness of a LSO background subtraction method, and to estimate the minimal detectable target activity (MDTA) of image object for SPECT imaging. For LSO background correction, the LSO contribution in an image study was estimated based on a pre-measured long LSO background scan and subtracted prior to the image reconstruction. The MDTA was estimated in two ways. The empirical MDTA (eMDTA) was estimated from screening the tomographic images at different activity levels. The calculated MDTA (cMDTA) was estimated from using a formula based on applying a modified Currie equation on an average projection dataset. Two simulated and two experimental phantoms with different object activity distributions and levels were used in this study. The results showed that LSO background adds concentric ring artifacts to the reconstructed image, and the simple subtraction method can effectively remove these artifacts-the effect of the correction was more visible when the object activity level was near or above the eMDTA. For the four phantoms studied, the cMDTA was consistently about five times of the corresponding eMDTA. In summary, we implemented a simple LSO background subtraction method and demonstrated its effectiveness. The projection-based calculation formula yielded MDTA results that closely correlate with that obtained empirically and may have predicative value for imaging applications.

  15. Lutetium oxyorthosilicate (LSO) intrinsic activity correction and minimal detectable target activity study for SPECT imaging with a LSO-based animal PET scanner

    NASA Astrophysics Data System (ADS)

    Yao, Rutao; Ma, Tianyu; Shao, Yiping

    2008-08-01

    This work is part of a feasibility study to develop SPECT imaging capability on a lutetium oxyorthosilicate (LSO) based animal PET system. The SPECT acquisition was enabled by inserting a collimator assembly inside the detector ring and acquiring data in singles mode. The same LSO detectors were used for both PET and SPECT imaging. The intrinsic radioactivity of 176Lu in the LSO crystals, however, contaminates the SPECT data, and can generate image artifacts and introduce quantification error. The objectives of this study were to evaluate the effectiveness of a LSO background subtraction method, and to estimate the minimal detectable target activity (MDTA) of image object for SPECT imaging. For LSO background correction, the LSO contribution in an image study was estimated based on a pre-measured long LSO background scan and subtracted prior to the image reconstruction. The MDTA was estimated in two ways. The empirical MDTA (eMDTA) was estimated from screening the tomographic images at different activity levels. The calculated MDTA (cMDTA) was estimated from using a formula based on applying a modified Currie equation on an average projection dataset. Two simulated and two experimental phantoms with different object activity distributions and levels were used in this study. The results showed that LSO background adds concentric ring artifacts to the reconstructed image, and the simple subtraction method can effectively remove these artifacts—the effect of the correction was more visible when the object activity level was near or above the eMDTA. For the four phantoms studied, the cMDTA was consistently about five times of the corresponding eMDTA. In summary, we implemented a simple LSO background subtraction method and demonstrated its effectiveness. The projection-based calculation formula yielded MDTA results that closely correlate with that obtained empirically and may have predicative value for imaging applications.

  16. 33 CFR 187.105 - What information on titled vessels must be collected and what may be collected?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... SYSTEM Information to be Collected by Participating States § 187.105 What information on titled vessels... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false What information on titled... information on a vessel it has titled and make it available to VIS: (1) Information required under §...

  17. 33 CFR 187.105 - What information on titled vessels must be collected and what may be collected?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... SYSTEM Information to be Collected by Participating States § 187.105 What information on titled vessels... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false What information on titled... information on a vessel it has titled and make it available to VIS: (1) Information required under §...

  18. 33 CFR 187.105 - What information on titled vessels must be collected and what may be collected?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... SYSTEM Information to be Collected by Participating States § 187.105 What information on titled vessels... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false What information on titled... information on a vessel it has titled and make it available to VIS: (1) Information required under §...

  19. 33 CFR 187.105 - What information on titled vessels must be collected and what may be collected?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... SYSTEM Information to be Collected by Participating States § 187.105 What information on titled vessels... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false What information on titled... information on a vessel it has titled and make it available to VIS: (1) Information required under §...

  20. 33 CFR 187.105 - What information on titled vessels must be collected and what may be collected?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... SYSTEM Information to be Collected by Participating States § 187.105 What information on titled vessels... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false What information on titled... information on a vessel it has titled and make it available to VIS: (1) Information required under §...

  1. RF Simulation of the 187 MHz CW Photo-RF Gun Cavity at LBNL

    SciTech Connect

    Huang, Tong-Ming

    2008-12-01

    A 187 MHz normal conducting Photo-RF gun cavity is designed for the next generation light sources. The cavity is capable of operating in CW mode. As high as 750 kV gap voltage can be achieved with a 20 MV/m acceleration gradient. The original cavity optimization is conducted using Superfish code (2D) by Staples. 104 vacuum pumping slots are added and evenly spaced over the cavity equator in order to achieve better than 10-10-Tor of vacuum. Two loop couplers will be used to feed RF power into the cavity. 3D simulations are necessary to study effects from the vacuum pumping slots, couplers and possible multipactoring. The cavity geometry is optimized to minimize the power density and avoid multipactoring at operating field level. The vacuum slot dimensions are carefully chosen in consideration of both the vacuum conduction, local power density enhancement and the power attenuation at the getter pumps. This technical note gives a summary of 3D RF simulation results, multipactoring simulations (2D) and preliminary electromagnetic-thermal analysis using ANSYS code.

  2. Os-187/Os-188 and Highly Siderophile Element Systematics of Apollo 17 Aphanitic Melt Rocks

    NASA Technical Reports Server (NTRS)

    Puchtel, I. S.; Walker, R. J.; James, O. B.

    2005-01-01

    Introduction: Generally chondritic relative abundances and high absolute abundances of the highly siderophile elements (HSE: Ru, Rh, Pd, Re, Os, Ir, Pt, Au) in Earth s upper mantle provide strong evidence that these elements were added to the Earth following the last major interaction between its metallic core and silicate fraction. So called "late accretion" may have added materials comprising as much as 0.8% of the total mass of the Earth and possibly a similar proportion of mass to the Moon. We have begun to study the chemical nature of late accreted materials to the Earth - Moon system by examining the HSE contained in lunar impact-melt rocks. The HSE contained in melt rocks were largely added to the Moon during the period of time from the origin of the lunar highlands crust (4.4- 4.5 Ga) to the end of the late bombardment period (ca. 3.9 Ga). These materials provide the only direct chemical link to the late accretionary period. The chemical fingerprints of the HSE in late accreted materials may enable us to ascertain under what conditions and where in the solar system the late accreted materials formed. The Os-187/Os-188 ratios (reflecting long-term Re/Os), coupled with ratios of other HSE, can be diagnostic for identifying the nature of the impactor. A critical issue, however, will be deconvolving the exogenous from indigenous components.

  3. X-ray structure of imidazolonepropionase from Agrobacterium tumefaciens at 1.87 Å resolution

    SciTech Connect

    Tyagi, Rajiv; Kumaran, Desigan; Burley, Stephen K.; Swaminathan, Subramanyam

    2010-01-12

    Histidine degradation in Agrobacterium tumefaciens involves four enzymes, including histidase (EC 4.3.1.3), urocanase (EC 4.2.1.49), imidazolonepropionase (EC 3.5.2.7), and N-formylglutamate amidohydrolase (EC 3.5.3.8). The third enzyme of the pathway, imidazolone-propionase, a 45.6 kDa protein, catalyzes conversion of imidazolone-5-propanoate to N-forminio-L-glutamate. Initial studies of the role of imidazolonepropionase in histidine degradation were published in 1953. Subsequent publications have been limited to enzyme kinetics, crystallization, and a recently reported structure determination. The imidazolonepropionases are members of metallodepenent-hydrolases (or amidohydroase) superfamily, which includs ureases, adenosine deaminases, phosphotriesterases, dihydroorotases, allantoinases, hydantoinases, adenine and cytosine deaminases, imidazolonepropionases, aryldial-kylphosphatases, chlorohydrolases, and formylmethanofuran dehydroases. Proteins belonging to this large group share a common three-dimensional structural motif (an eightfold {alpha}/{beta} or TIM barrel) with similar active sites. Most superfamily members also share a conserved metal binding site, involving four histidine residues and one aspartic acid. Imidazolonepropionase is one of the targets selected for X-ray crystallpgrahpic structure determination by the New York Structural GenomiX Research Consortium (NYSGXRC) Target ID: 9252b to correlate the structure function relationship of poorly studied by important enzyme. Here they report the crystal structure of imidazolonepropionase from Agrobacterium tumefaciens determined at 1.87 {angstrom} resolution.

  4. UHPLC/ESI-MS/MS Determination of 187 Pesticides in Wine.

    PubMed

    Wang, Jian; Cheung, Wendy

    2016-01-01

    This paper presents an ultra HPLC/electrospray ionization-tandem MS method to determine pesticides in wine. We adopted the quick, easy, cheap, effective, rugged, and safe (QuEChERs) method for extraction and used core-shell column to achieve ultra-HPLC to develop and validate a simple and fast method to analyze 187 pesticide residues in red and white wine samples. Pesticide residues were extracted from wine samples using QuEChERS. Ultra HPLC/electrospray ionization-tandem MS quantification was achieved using matrix-matched standard calibration curves with isotopically labeled standards or a chemical analogue as internal standards with an analytical range from 5.0 to 500.0 μg/L. The method performance characteristics that included overall recovery, intermediate precision, and measurement uncertainty were evaluated according to a nested experimental design. Generally, 98.4% (in red wine) and 96.8% (in white wine) of the pesticides had recoveries between 71 and 120%; 98.9% (in red wine) and 99.5% (in white wine) of the pesticides had the intermediate precision ≤20%; and 99.5% (in red wine) and 98.4% (in white wine) of the pesticides had measurement uncertainty ≤50%.

  5. A new young stellar object in the S 187 complex: Photometry and spectroscopy

    NASA Astrophysics Data System (ADS)

    Zavagno, A.; Deharveng, L.; Caplan, J.

    1994-01-01

    We report the discovery in the S 187 complex of a young stellar object with an optical counterpart. High resolution spectroscopy in the red and near infrared indicates that this object is a pre-main-sequence star. In the red, the spectrumis dominated by a very bright H-alpha line with a total width (wing to wing) greater than 1000 km/s. This line exhibits a special type of P Cygni profile (Beal's Type III). The object's near infrared spectrum is dominated by the Ca II triplet emission at 8498 A, 8542 A, and 8662 A; these lines are broad and optically thick. Numerous Fe I and Fe II emission lines are observed also, B, V, R, I, H, K, and L magnitudes of the object, as well as its H-alpha luminosity, indicate that it is probably a Herbig late Be or early Ae star. It presents many characteristics of the 'outflow group' of Herbig stars identified by Hamann & Persson (1992B); it is very similar, both in luminosity and geometry, to the well-known young stellar objects V645 Cyh and R Mon.

  6. Distribution and excretion of 2,2',3,4',5,5',6-heptachlorobiphenyl (CB187) and its metabolites in rats and guinea pigs.

    PubMed

    Ohta, Chiho; Haraguchi, Koichi; Kato, Yoshihisa; Endo, Tetsuya; Kimura, Osamu; Koga, Nobuyuki

    2015-01-01

    4-Hydroxy (OH)-2,2',3,4',5,5',6-heptachlorobiphenyl (CB187) is a polychlorinated biphenyl (PCB) metabolite present in human serum at the highest concentration of the PCB metabolites. Our previous study demonstrated that CB187 was metabolized by rat and guinea pig liver microsomes to the major metabolite 4'-OH-2,2',3,3',5,5',6-heptachlorobiphenyl (CB178), and the two minor metabolites 4-OH-CB187 and 4'-OH-2,2',3,5,5',6-hexachlorobiphenyl (CB151). In this study, the distribution of these metabolites in serum, liver and kidney, and their fecal excretion, were examined in rats and guinea pigs intraperitoneally dosed with CB187. Similarly to the in vitro study, 4'-OH-CB178 was a major metabolite in the liver, serum and feces of both animal species on day 4 after CB187 injection, and the level in the liver was about 20 times higher in untreated guinea pigs than in untreated rats. In addition, 4-OH-CB187, a minor metabolite, was detected in the serum and kidneys, but not in the feces, of both guinea pigs and rats. Another minor metabolite, 4'-OH-CB151, was detected at a lower level only in guinea pig feces; little was found in the serum or liver of either animals. Over the 30d following CB187 injection into guinea pigs, 4'-OH-CB178 and 4-OH-CB187 in the serum was observed at higher level on day 4 and day 16 after injection, respectively. The majority of the 4'-OH-CB178 was rapidly excreted to the feces following unmetabolized CB187, whereas 4-OH-CB187 was not found in guinea pig feces and liver during 30d. These results support previous reports that 4-OH-CB187 is retained persistently in animal blood.

  7. Dynamic Nuclear Polarization enhanced NMR at 187 GHz/284 MHz using an Extended Interaction Klystron amplifier

    NASA Astrophysics Data System (ADS)

    Kemp, Thomas F.; Dannatt, Hugh R. W.; Barrow, Nathan S.; Watts, Anthony; Brown, Steven P.; Newton, Mark E.; Dupree, Ray

    2016-04-01

    A Dynamic Nuclear Polarisation (DNP) enhanced solid-state Magic Angle Spinning (MAS) NMR spectrometer which uses a 187 GHz (corresponding to 1H NMR frequency of 284 MHz) Extended Interaction Klystron (EIK) amplifier as the microwave source is briefly described. Its performance is demonstrated for a biomolecule (bacteriorhodopsin), a pharmaceutical, and surface functionalised silica. The EIK is very compact and easily incorporated into an existing spectrometer. The bandwidth of the amplifier is sufficient that it obviates the need for a sweepable magnetic field, once set, for all commonly used radicals. The variable power (CW or pulsed) output from the EIK is transmitted to the DNP-NMR probe using a quasi-optic system with a high power isolator and a corrugated waveguide which feeds the microwaves into the DNP-NMR probe. Curved mirrors inside the probe project the microwaves down the axis of the MAS rotor, giving a very efficient system such that maximum DNP enhancement is achieved with less than 3 W output from the microwave source. The DNP-NMR probe operates with a sample temperature down to 90 K whilst spinning at 8 kHz. Significant enhancements, in excess of 100 for bacteriorhodopsin in purple membrane (bR in PM), are shown along with spectra which are enhanced by ≈25 with respect to room temperature, for both the pharmaceutical furosemide and surface functionalised silica. These enhancements allow hitherto prohibitively time consuming experiments to be undertaken. The power at which the DNP enhancement in bR in PM saturates does not change significantly between 90 K and 170 K even though the enhancement drops by a factor of ≈11. As the DNP build up time decreases by a factor 3 over this temperature range, the reduction in T1n is presumably a significant contribution to the drop in enhancement.

  8. Biodegradable PLGA85/15 nanoparticles as a delivery vehicle for Chlamydia trachomatis recombinant MOMP-187 peptide

    NASA Astrophysics Data System (ADS)

    Taha, Murtada A.; Singh, Shree R.; Dennis, Vida A.

    2012-08-01

    Development of a Chlamydia trachomatis vaccine has been a formidable task partly because of an ineffective delivery system. Our laboratory has generated a recombinant peptide of C. trachomatis major outer membrane protein (MOMP) (rMOMP-187) and demonstrated that it induced at 20 μg ml-1 maximal interleukin (IL)-6 and IL-12p40 Th1 cytokines in mouse J774 macrophages. In a continuous pursuit of a C. trachomatis effective vaccine-delivery system, we encapsulated rMOMP-187 in poly(d,l-lactic-co-glycolic acid) (PLGA, 85:15 PLA/PGA ratio) to serve as a nanovaccine candidate. Physiochemical characterizations were assessed by Fourier transform-infrared spectroscopy, atomic force microscopy, Zetasizer, Zeta potential, transmission electron microcopy and differential scanning calorimetry. The encapsulated rMOMP-187 was small (˜200 nm) with an apparently smooth uniform oval structure, thermally stable (54 °C), negatively charged ( - 27.00 mV) and exhibited minimal toxicity at concentrations <250 μg ml -1 to eukaryotic cells (>95% viable cells) over a 24-72 h period. We achieved a high encapsulation efficiency of rMOMP-187 (˜98%) in PLGA, a loading peptide capacity of 2.7% and a slow release of the encapsulated peptide. Stimulation of J774 macrophages with a concentration as low as 1 μg ml -1 of encapsulated rMOMP-187 evoked high production levels of the Th1 cytokines IL-6 (874 pg ml-1) and IL-12p40 (674 pg ml-1) as well as nitric oxide (8 μM) at 24 h post-stimulation, and in a dose-response and time-kinetics manner. Our data indicate the successful encapsulation and characterization of rMOMP-187 in PLGA and, more importantly, that PLGA enhanced the capacity of the peptide to induce Th1 cytokines and NO in vitro. These findings make this nanovaccine an attractive candidate in pursuit of an efficacious vaccine against C. trachomatis.

  9. MiR-187 Targets the Androgen-Regulated Gene ALDH1A3 in Prostate Cancer.

    PubMed

    Casanova-Salas, Irene; Masiá, Esther; Armiñán, Ana; Calatrava, Ana; Mancarella, Caterina; Rubio-Briones, José; Scotlandi, Katia; Vicent, Maria Jesús; López-Guerrero, José Antonio

    2015-01-01

    miRNAs are predicted to control the activity of approximately 60% of all protein-coding genes participating in the regulation of several cellular processes and diseases, including cancer. Recently, we have demonstrated that miR-187 is significantly downregulated in prostate cancer (PCa) and here we propose a proteomic approach to identify its potential targets. For this purpose, PC-3 cells were transiently transfected with miR-187 precursor and miRNA mimic negative control. Proteins were analyzed by a two-dimensional difference gel electrophoresis (2D-DIGE) and defined as differentially regulated if the observed fold change was ±1.06. Then, MALDI-TOF MS analysis was performed after protein digestion and low abundance proteins were identified by LC-MS/MS. Peptides were identified by searching against the Expasy SWISS PROT database, and target validation was performed both in vitro by western blot and qRT-PCR and in clinical samples by qRT-PCR, immunohistochemistry and ELISA. DIGE analysis showed 9 differentially expressed spots (p<0.05) and 7 showed a down-regulated expression upon miR-187 re-introduction. Among these targets we identified aldehyde dehydrogenase 1A3 (ALDH1A3). ALDH1A3 expression was significantly downregulated in PC3, LNCaP and DU-145 cells after miR-187 re-introduction. Supporting these data, the expression of ALDH1A3 was found significantly (p<0.0001) up-regulated in PCa samples and inversely correlated (p<0.0001) with miR-187 expression, its expression being directly associated with Gleason score (p = 0.05). The expression of ALDH1A3 was measured in urine samples to evaluate the predictive capability of this biomarker for the presence of PCa and, at a signification level of 10%, PSA and also ALDH1A3 were significantly associated with a positive biopsy of PCa. In conclusion, our data illustrate for the first time the role of ALDH1A3 as a miR-187 target in PCa and provide insights in the utility of using this protein as a new biomarker for PCa.

  10. MiR-187 Targets the Androgen-Regulated Gene ALDH1A3 in Prostate Cancer

    PubMed Central

    Casanova-Salas, Irene; Masiá, Esther; Armiñán, Ana; Calatrava, Ana; Mancarella, Caterina; Rubio-Briones, José; Scotlandi, Katia; Vicent, Maria Jesús; López-Guerrero, José Antonio

    2015-01-01

    miRNAs are predicted to control the activity of approximately 60% of all protein-coding genes participating in the regulation of several cellular processes and diseases, including cancer. Recently, we have demonstrated that miR-187 is significantly downregulated in prostate cancer (PCa) and here we propose a proteomic approach to identify its potential targets. For this purpose, PC-3 cells were transiently transfected with miR-187 precursor and miRNA mimic negative control. Proteins were analyzed by a two-dimensional difference gel electrophoresis (2D-DIGE) and defined as differentially regulated if the observed fold change was ±1.06. Then, MALDI-TOF MS analysis was performed after protein digestion and low abundance proteins were identified by LC–MS/MS. Peptides were identified by searching against the Expasy SWISS PROT database, and target validation was performed both in vitro by western blot and qRT-PCR and in clinical samples by qRT-PCR, immunohistochemistry and ELISA. DIGE analysis showed 9 differentially expressed spots (p<0.05) and 7 showed a down-regulated expression upon miR-187 re-introduction. Among these targets we identified aldehyde dehydrogenase 1A3 (ALDH1A3). ALDH1A3 expression was significantly downregulated in PC3, LNCaP and DU-145 cells after miR-187 re-introduction. Supporting these data, the expression of ALDH1A3 was found significantly (p<0.0001) up-regulated in PCa samples and inversely correlated (p<0.0001) with miR-187 expression, its expression being directly associated with Gleason score (p = 0.05). The expression of ALDH1A3 was measured in urine samples to evaluate the predictive capability of this biomarker for the presence of PCa and, at a signification level of 10%, PSA and also ALDH1A3 were significantly associated with a positive biopsy of PCa. In conclusion, our data illustrate for the first time the role of ALDH1A3 as a miR-187 target in PCa and provide insights in the utility of using this protein as a new biomarker for PCa

  11. {alpha}-decay of the new isotope {sup 187}Po: Probing prolate structures beyond the neutron mid-shell at N = 104

    SciTech Connect

    Andreyev, A.N.; Antalic, S.

    2006-04-15

    The new neutron-deficient isotope {sup 187}Po has been identified in the complete fusion reaction {sup 46}Ti+{sup 144}Sm{yields}{sup 187}Po+3n at the velocity filter SHIP. Striking features of the {sup 187}Po {alpha} decay are the strongly-hindered decay to the spherical ground state and unhindered decay to a surprisingly low-lying deformed excited state at 286 keV in the daughter nucleus {sup 183}Pb. Based on the potential energy surface calculations, the {sup 187}Po ground state and the 286 keV excited state in {sup 183}Pb were interpreted as being of prolate origin. The systematic deviation of the {alpha}-decay properties in the lightest odd-A Po isotopes relative to the smooth behavior in the even-A neighbors is discussed. Improved data for the decay of {sup 187}Bi{sup m,g} were also obtained.

  12. Long Non-Coding RNA Uc.187 Is Upregulated in Preeclampsia and Modulates Proliferation, Apoptosis, and Invasion of HTR-8/SVneo Trophoblast Cells.

    PubMed

    Cao, Chunyu; Li, Jingyun; Li, Jun; Liu, Lan; Cheng, Xiaoyan; Jia, Ruizhe

    2017-06-01

    Among the preeclampsia-related long non-cording RNAs (lncRNAs) screened with a gene chip in our preliminary study, uc.187 attracted our attention because of its high conservation across different species and significant positive correlation with preeclampsia (PE). The literature and bioinformatics analysis suggested that lncRNA uc.187 might be associated with cell growth, invasion, and apoptosis. The expression of uc.187 in severe preeclamptic placentas (n = 31) and normal placentas (n = 18) was evaluated by real-time reverse transcription polymerase chain reaction (qRT-PCR). We constructed a silencing lentivirus vector (uc.187 siRNA) to explore the biological function of uc.187 in the development and progression of HTR-8/SVneo trophoblast cells in vitro. Furthermore, we utilized CCK8 analysis, a transwell invasion assay, and flow cytometry to determine the role of uc.187 in the proliferation, invasion, and apoptosis of HTR-8/SVneo trophoblast cells. The proteins related to proliferation (PCNA, Ki67), invasion (MMP-2/-9 and TIMP-1), and apoptosis (caspase-3, Bcl-2) were evaluated with a Western blot assay. The results showed that there was an obvious upregulation of uc.187 expression in preeclamptic placental tissues. In addition, uc.187 silencing enhanced cell proliferation and invasion and reduced the cellular apoptotic response. Taken together, our findings suggest for the first time that abnormal expression of lncRNA uc.187 may lead to the aberrant biological behavior of HTR-8/SVneo cells. Therefore, we propose uc.187 as a novel lncRNA molecule that might contribute to the development of PE and might represent a potential diagnostic and therapeutic target for this disease. J. Cell. Biochem. 118: 1462-1470, 2017. © 2016 Wiley Periodicals, Inc.

  13. New insight into the structure of thiolated gold clusters: a structural prediction of the Au187(SR)68 cluster.

    PubMed

    Tlahuice-Flores, A

    2015-02-28

    The structure of the thiolated Au187 cluster has been elucidated by density functional theory calculations. The structural model comprises a Marks-decahedral Au153 core protected with 34 monomer motifs. The predicted structure accomplished in this study is in good agreement with the experimental X-ray diffraction pattern. It is noteworthy that the used methodology represents an advance in the prediction of the molecular structure of thiolated gold clusters constituted by hundreds of gold atoms.

  14. Neutron capture and inelastic scattering cross sections for {sup 186}Os, {sup 187}Os, and {sup 189}Os and the Re-Os chronology

    SciTech Connect

    Segawa, M.; Nagai, Y.; Masaki, T.; Temma, Y.; Shima, T.; Mishima, K.; Igashira, M.; Goriely, S.; Koning, A.; Hilaire, S.

    2008-05-21

    We measured the neutron capture cross sections of {sup 186,187,189}Os taking for the first time their pulse height spectra for neutrons between 5 and 90 keV by means of an anti-Compton NaI(Tl) spectrometer. The neutron inelastic scattering cross section for {sup 187}Os as well as the neutron elastic scattering cross sections for {sup 186,187}Os were also observed with use of {sup 6}Li-glass scintillation detectors with a small systematic uncertainty.

  15. Neutron physics of the Re/Os clock. II. The (n,n{sup '}) cross section of {sup 187}Os at 30 keV neutron energy

    SciTech Connect

    Mosconi, M.; Heil, M.; Kaeppeler, F.; Plag, R.; Mengoni, A.

    2010-07-15

    The inelastic neutron-scattering cross section of {sup 187}Os has been determined in a time-of-flight experiment at the Karlsruhe 3.7-MV Van de Graaff accelerator. An almost monoenergetic beam of 30-keV neutrons was produced at the threshold of the {sup 7}Li(p,n){sup 7}Be reaction. Information on the inelastic channel is required for reliable calculations of the so-called stellar enhancement factor, by which the laboratory cross section of {sup 187}Os must be corrected in order to account for the thermal population of low-lying excited states at the temperatures of s-process nucleosynthesis, in particular of the important state at 9.75 keV. This correction represents a crucial step in the interpretation of the {sup 187}Os/{sup 187}Re pair as a cosmochronometer.

  16. TEM-187, a new extended-spectrum β-lactamase with weak activity in a Proteus mirabilis clinical strain.

    PubMed

    Corvec, Stéphane; Beyrouthy, Racha; Crémet, Lise; Aubin, Guillaume Ghislain; Robin, Frédéric; Bonnet, Richard; Reynaud, Alain

    2013-05-01

    A Proteus mirabilis clinical strain (7001324) was isolated from urine sample of a patient hospitalized in a long-term-care facility. PCR and cloning experiments performed with this strain identified a novel TEM-type β-lactamase (TEM-187) differing by four amino acid substitutions (Leu21Phe, Arg164His, Ala184Val, and Thr265Met) from TEM-1. This characterization provides further evidence for the diversity of extended-spectrum β-lactamases (ESBL) produced by P. mirabilis and for their potential spread to other Enterobacteriaceae due to a lack of sensitive detection methods used in daily practice.

  17. Analysis of complete, incomplete and total fusion data of 9Be +169Tm, 187Re, 209Bi reactions

    NASA Astrophysics Data System (ADS)

    Kharab, Rajesh; Chahal, Rajiv; Kumar, Rajiv

    2016-11-01

    We have analyzed the incomplete fusion (ICF), complete fusion (CF) and total fusion (TF) excitation functions for reactions induced by 9Be on 169Tm, 187Re and 209Bi targets at near barrier energies using Wong’s formula in conjunction with the energy dependent Woods-Saxon potential. A phenomenological selection function is proposed to separate out the contribution of ICF and CF cross-sections in TF cross-section. The variation of relative contribution of ICF and CF in TF with respect to incident beam energy is very well reproduced through this approach.

  18. Final Environmental Assessment for Temporary Aircraft Relocation to Maxwell Air Force Base 187th Fighter Wing Montgomery Regional Airport Montgomery, Alabama

    DTIC Science & Technology

    2012-06-01

    Maxwell AFB, 187 FW Final – June 2012 8-1 CHAPTER 8 LIST OF PREPARERS Robert Dogan, REM Project Manager National Guard Bureau/A7AM Years of...and draft FONSI 2. Distribution li st Sincere ly ~/()/ ROBERT L. DOGAN, GS-13, REM Plans and Requi rements Branch Environmental Assessment for...ROBERT L. DOGAN, GS-13, REM Plans and Requirements Branch Environmental Assessment for Temporary Aircraft Relocation to Maxwell AFB, 187 FW Final

  19. TMEM187-IRAK1 Polymorphisms Associated with Rheumatoid Arthritis Susceptibility in Tunisian and French Female Populations: Influence of Geographic Origin

    PubMed Central

    Lambert, Nathalie; Auger, Isabelle; Roudier, Jean; Sénéchal, Audrey; Geneviève, David; Lefranc, Gérard; Mrenda, Bakridine M'Madi; Benedito, Cécilia; Pardoux, Etienne; Gagez, Anne-Laure; Jorgensen, Christian; Mahjoub, Touhami

    2017-01-01

    Polymorphisms have been identified in the Xq28 locus as risk loci for rheumatoid arthritis (RA). Here, we investigated the association between three polymorphisms in the Xq28 region containing TMEM187 and IRAK1 (rs13397, rs1059703, and rs1059702) in two unstudied populations: Tunisian and French. The rs13397 G and rs1059703 T major alleles were significantly increased in RA patients (n = 408) compared with age-matched controls (n = 471) in both Tunisian and French women. These results were confirmed by a meta-analysis replication study including two independent Greek and Korean cohorts. The rs1059702 C major allele was significantly associated with RA, only with French women. In the French population, the GTC haplotype displayed a protective effect against RA, while the ATC, GCC, and GTT haplotypes conferred significant risk for RA. No association for these haplotypes was found in the Tunisian population. Our results replicated for the first time the association of the three Xq28 polymorphisms with RA risk in Tunisian and French populations and suggested that RA susceptibility is associated with TMEM187-IRAK1 polymorphisms in women. Our data further support the involvement of X chromosome in RA susceptibility and evidence ethnicities differences that might be explained by differences in the frequencies of SE HLA-DRB1 alleles between both populations. PMID:28271077

  20. Development of Metallic Magnetic Calorimeters for High Precision Measurements of Calorimetric Re-187 and Ho-163 Spectra

    NASA Technical Reports Server (NTRS)

    Ranitzsch, P. C.-O.; Porst, J.-P.; Kempf, S.; Pies, C.; Schafer, S.; Hengstler, D.; Fleischmann, A.; Enss, C.; Gastaldo, L.

    2012-01-01

    The measurement of calorimetric spectra following atomic weak decays, beta (b) and electron capture (EC), of nuclides having a very low Q-value, can provide an impressively high sensitivity to a non-vanishing neutrino mass. The achievable sensitivity in this kind of experiments is directly connected to the performance of the used detectors. In particular an energy resolution of a few eV and a pulse formation time well below 1 microsecond are required. Low temperature Metallic Magnetic Calorimeters (MMCs) for soft X-rays have already shown an energy resolution of 2.0 eV FWHM and a pulse rise-time of about 90 ns for fully micro-fabricated detectors. We present the use of MMCs for high precision measurements of calorimetric spectra following the beta-decay of Re-187 and the EC of Ho-163. We show results obtained with detectors optimized for Re-187 and for Ho-163 experiments respectively. While the detectors equipped with superconducting Re absorbers have not yet reached the aimed performance, a first detector prototype with a Au absorber having implanted Ho-163 ions already shows excellent results. An energy resolution of 12 eV FWHM and a rise time of 90 ns were measured.

  1. MicroRNA-187, down-regulated in clear cell renal cell carcinoma and associated with lower survival, inhibits cell growth and migration though targeting B7-H3

    SciTech Connect

    Zhao, Jun; Lei, Ting; Xu, Congjie; Li, Huan; Ma, Wenmin; Yang, Yunxia; Fan, Shuming; Liu, Yuchen

    2013-08-23

    Highlights: •miR-187 is down-regulated in clear cell renal cell carcinoma (ccRCC). •Down-regulation of miR-187 is associated with poor outcomes in patients with ccRCC. •miR-187 inhibits cell growth and migration though targeting B7-H3 in ccRCC. -- Abstract: Aberrantly expressed microRNAs (miRNAs) are frequently associated with the aggressive malignant behavior of human cancers, including clear cell renal cell carcinoma (ccRCC). Based on the preliminary deep sequencing data, we hypothesized that miR-187 may play an important role in ccRCC development. In this study, we found that miR-187 was down-regulated in both tumor tissue and plasma of ccRCC patients. Lower miR-187 expression levels were associated with higher tumor grade and stage. All patients with high miR-187 expression survived 5 years, while with low miR-187 expression, only 42% survived. Suppressed in vitro proliferation, inhibited in vivo tumor growth, and decreased motility were observed in cells treated with the miR-187 expression vector. Further studies showed that B7 homolog 3 (B7-H3) is a direct target of miR-187. Over-expression of miR-187 decreased B7-H3 mRNA level and repressed B7-H3-3′-UTR reporter activity. Knockdown of B7-H3 using siRNA resulted in similar phenotype changes as that observed for overexpression of miR-187. Our data suggest that miR-187 is emerging as a novel player in the disease state of ccRCC. miR-187 plays a tumor suppressor role in ccRCC.

  2. One-neutron stripping from 9Be to 181Ta, 169Tm, 187Re and at near-barrier energies

    NASA Astrophysics Data System (ADS)

    Fang, Y. D.; Gomes, P. R. S.; Lubian, J.; Ferreira, J. L.; Mendes Junior, D. R.; Zhou, X. H.; Liu, M. L.; Zhang, N. T.; Zhang, Y. H.; Li, G. S.; Wang, J. G.; Guo, S.; Qiang, Y. H.; Gao, B. S.; Zheng, Y.; Lei, X. G.; Wang, Z. G.

    2016-03-01

    We report the measurement of one-neutron stripping of 9Be to the 181Ta, 187Re and nuclei, in the range from subbarrier to above-barrier energies. The activation technique was used, with the detection of off-line γ rays. The results show that the transfer cross sections for the three systems investigated are very similar and are much larger than the corresponding fusion cross sections at subbarrier energies, whereas fusion predominates at energies above the barrier. Data are in good agreement with our coupled reaction channel calculations. We also investigate the ratio, as a function of energy, between experimental transfer and fusion cross sections. The role of transfer couplings on the fusion excitation functions is also discussed.

  3. Determination of CA-41, I-129 and OS-187 in the Rochester tandem accelerator and some applications of these isotopes

    NASA Technical Reports Server (NTRS)

    Fehn, U.; Elmore, D.; Gove, H. E.; Kubik, P.; Teng, R.; Tubbs, L.

    1986-01-01

    The measurement of Ca-41 and I-129 utilizing the Rochester Tanden Accelerator Mass Spectrometer (TAMS) is discussed. Ca-41, having a half-life of 100,000 yrs., is of potential use for the dating of ground water as well as of bones in the age range between 50,000 and 1 million yrs. A major problem for the measurement of Ca-41 with TAMS is the fact that calcium does not readily form negative atomic ions. It does, however, form negative molecular ions. The production of CaO ions from compounds such as CaO and CaCO3 and from free Ca molecules sprayed with oxygen gas was studied. A project to utilize I-129 as a tracer for hydrothermal convection in sediment-covered oceanic crust is also briefly described. Finally, plans to use the Os-187/Os-186 ratio for the determination of extraterrestrial material in the Ries crater in Germany are summarized.

  4. Crystal structure of Escherichia coli malate dehydrogenase. A complex of the apoenzyme and citrate at 1.87 A resolution.

    PubMed

    Hall, M D; Levitt, D G; Banaszak, L J

    1992-08-05

    The crystal structure of malate dehydrogenase from Escherichia coli has been determined with a resulting R-factor of 0.187 for X-ray data from 8.0 to 1.87 A. Molecular replacement, using the partially refined structure of porcine mitochondrial malate dehydrogenase as a probe, provided initial phases. The structure of this prokaryotic enzyme is closely homologous with the mitochondrial enzyme but somewhat less similar to cytosolic malate dehydrogenase from eukaryotes. However, all three enzymes are dimeric and form the subunit-subunit interface through similar surface regions. A citrate ion, found in the active site, helps define the residues involved in substrate binding and catalysis. Two arginine residues, R81 and R153, interacting with the citrate are believed to confer substrate specificity. The hydroxyl of the citrate is hydrogen-bonded to a histidine, H177, and similar interactions could be assigned to a bound malate or oxaloacetate. Histidine 177 is also hydrogen-bonded to an aspartate, D150, to form a classic His.Asp pair. Studies of the active site cavity indicate that the bound citrate would occupy part of the site needed for the coenzyme. In a model building study, the cofactor, NAD, was placed into the coenzyme site which exists when the citrate was converted to malate and crystallographic water molecules removed. This hypothetical model of a ternary complex was energy minimized for comparison with the structure of the binary complex of porcine cytosolic malate dehydrogenase. Many residues involved in cofactor binding in the minimized E. coli malate dehydrogenase structure are homologous to coenzyme binding residues in cytosolic malate dehydrogenase. In the energy minimized structure of the ternary complex, the C-4 atom of NAD is in van der Waals' contact with the C-3 atom of the malate. A catalytic cycle involves hydride transfer between these two atoms.

  5. [Presence of enterotoxin C and toxic shock syndrome toxin--1 (TSST-1) genes in population of Staphylococcus aureus phage type 187].

    PubMed

    Garbacz, Katarzyna; Piechowicz, Lidia; Galiński, Janusz

    2006-01-01

    The aim of this study was to examine whether Staphylococcus aureus of phage type 187 possess the genes of enterotoxins and toxic shock syndrom toxin. Sixteen phage type 187 strains were isolated from the hospital patients (12) and the carriers (4) in twelve medical centres in Poland during 1991 and 2005. Biotyping, phage typing, antibiotic susceptibility, detection of the genes of enterotoxins (sea--sed) and toxic shock syndrome toxin (tst) was tested. The results of this study showed that all staphylococci of phage type 187 belonged to the human biotype (A) and appeared to be sensitive to all of the tested antibiotics, including methicillin (MSSA). Almost all of them (93.8%) had the enterotoxin C gene and TSST-1 gene. This fact allows to consider them the strains of potentially high virulence.

  6. Substituting Threonine 187 with Alanine in p27Kip1 Prevents Pituitary Tumorigenesis by Two-Hit Loss of Rb1 and Enhances Humoral Immunity in Old Age*

    PubMed Central

    Zhao, Hongling; Bauzon, Frederick; Bi, Enguang; Yu, J. Jessica; Fu, Hao; Lu, Zhonglei; Cui, Jinhua; Jeon, Hyungjun; Zang, Xingxing; Ye, B. Hilda; Zhu, Liang

    2015-01-01

    p27Kip1 (p27) is an inhibitor of cyclin-dependent kinases. Inhibiting p27 protein degradation is an actively developing cancer therapy strategy. One focus has been to identify small molecule inhibitors to block recruitment of Thr-187-phosphorylated p27 (p27T187p) to SCFSkp2/Cks1 ubiquitin ligase. Since phosphorylation of Thr-187 is required for this recruitment, p27T187A knockin (KI) mice were generated to determine the effects of systemically blocking interaction between p27 and Skp2/Cks1 on tumor susceptibility and other proliferation related mouse physiology. Rb1+/− mice develop pituitary tumors with full penetrance and the tumors are invariably Rb1−/−, modeling tumorigenesis by two-hit loss of RB1 in humans. Immunization induced humoral immunity depends on rapid B cell proliferation and clonal selection in germinal centers (GCs) and declines with age in mice and humans. Here, we show that p27T187A KI prevented pituitary tumorigenesis in Rb1+/− mice and corrected decline in humoral immunity in older mice following immunization with sheep red blood cells (SRBC). These findings reveal physiological contexts that depend on p27 ubiquitination by SCFSkp2-Cks1 ubiquitin ligase and therefore help forecast clinical potentials of Skp2/Cks1-p27T187p interaction inhibitors. We further show that GC B cells and T cells use different mechanisms to regulate their p27 protein levels, and propose a T helper cell exhaustion model resembling that of stem cell exhaustion to understand decline in T cell-dependent humoral immunity in older age. PMID:25583987

  7. Substituting threonine 187 with alanine in p27Kip1 prevents pituitary tumorigenesis by two-hit loss of Rb1 and enhances humoral immunity in old age.

    PubMed

    Zhao, Hongling; Bauzon, Frederick; Bi, Enguang; Yu, J Jessica; Fu, Hao; Lu, Zhonglei; Cui, Jinhua; Jeon, Hyungjun; Zang, Xingxing; Ye, B Hilda; Zhu, Liang

    2015-02-27

    p27Kip1 (p27) is an inhibitor of cyclin-dependent kinases. Inhibiting p27 protein degradation is an actively developing cancer therapy strategy. One focus has been to identify small molecule inhibitors to block recruitment of Thr-187-phosphorylated p27 (p27T187p) to SCF(Skp2/Cks1) ubiquitin ligase. Since phosphorylation of Thr-187 is required for this recruitment, p27T187A knockin (KI) mice were generated to determine the effects of systemically blocking interaction between p27 and Skp2/Cks1 on tumor susceptibility and other proliferation related mouse physiology. Rb1(+/-) mice develop pituitary tumors with full penetrance and the tumors are invariably Rb1(-/-), modeling tumorigenesis by two-hit loss of RB1 in humans. Immunization induced humoral immunity depends on rapid B cell proliferation and clonal selection in germinal centers (GCs) and declines with age in mice and humans. Here, we show that p27T187A KI prevented pituitary tumorigenesis in Rb1(+/-) mice and corrected decline in humoral immunity in older mice following immunization with sheep red blood cells (SRBC). These findings reveal physiological contexts that depend on p27 ubiquitination by SCF(Skp2-Cks1) ubiquitin ligase and therefore help forecast clinical potentials of Skp2/Cks1-p27T187p interaction inhibitors. We further show that GC B cells and T cells use different mechanisms to regulate their p27 protein levels, and propose a T helper cell exhaustion model resembling that of stem cell exhaustion to understand decline in T cell-dependent humoral immunity in older age.

  8. Re-Os isotope systematics in black shales from the Lesser Himalaya: their chronology and role in the 187Os/ 188Os evolution of seawater

    NASA Astrophysics Data System (ADS)

    Singh, Sunil K.; Trivedi, J. R.; Krishnaswami, S.

    1999-08-01

    Re and Os abundances and Os isotope systematics have been measured in a number of black shales sampled from outcrops and two underground phosphorite mines, Maldeota and Durmala, in the Lesser Himalaya. The Re and Os concentrations in these samples exhibit wide range, 0.2 to 264 ng/g and 0.02 to 13.5 ng/g, respectively, with a mean Re/Os of ˜25. The 187Os/ 188Os of these samples also show a broad range 1.02 to 11.6, with many of them far more radiogenic than the currently eroding continental crust. The black shales from the Maldeota and Durmala mines, collected a few meters above the Krol-Tal (Pc-C) boundary and occurring in the same stratigraphic horizon, yield 187Re- 187Os isochron ages of 554 ± 16 and 552 ± 22 Ma, respectively, consistent with fossil evidences and those assigned for the Pc-C boundary at various other locations. These results indicate closed system behaviour of Re and Os in these mine samples and reaffirm the validity of 187Re- 187Os pair to date organic-rich sediments. The age of these mine samples from the outer belt seems to be a few hundred millions of years younger than the preliminary Re-Os age of 839 ± 138 Ma for black shales from Theog, collected from the inner belt. These initial results lean toward the hypothesis that the inner belt sediments were deposited earlier than the outer belt; however, more analyses of black shales are needed to confirm this. The role of weathering black shales from the Himalaya in contributing to the Os isotope evolution of seawater over the past ˜25 Ma was assessed using a simple budget model for seawater Os and assuming values for Os fluxes and 187Os/ 188Os based on the available limited data on Os concentration and its 187Os/ 188Os in rivers and oceans. These calculations indicate that the required contributions from black shale weathering to account for the entire increase in oceanic 187Os/ 188Os over the past ˜16 Ma is difficult to satisfy by varying only the Os flux from HTP rivers ( 187Os/ 188Os

  9. Role of tunnelling in complete and incomplete fusion induced by 9Be on 169Tm and 187Re targets at around barrier energies

    NASA Astrophysics Data System (ADS)

    Kharab, Rajesh; Chahal, Rajiv; Kumar, Rajiv

    2017-04-01

    We have analyzed the complete and incomplete fusion excitation function for 9Be +169Tm, 187Re reactions at around barrier energies using the code PLATYPUS based on classical dynamical model. The quantum mechanical tunnelling correction is incorporated at near and sub barrier energies which significantly improves the matching between the data and prediction.

  10. Staphylococcus aureus of phage type 187 isolated from people occurred to be a genes carrier of eneterotoxin C and toxic shock syndrome toxin-1 (TSST-1).

    PubMed

    Piechowicz, Lidia; Garbacz, Katarzyna; Galiński, Janusz

    2008-07-01

    The aim of this study was to examine the genotype properties of Staphylococcus aureus of phage type 187 strains that constitute a separate group among the strains of S. aureus. Sixteen strains were collected from the hospital patients (n=12) and the healthy carriers (n=4) in 13 medical centres in Poland during 1991 and 2005. Biotyping, antibiotic susceptibility, phage typing, detection the genes of enterotoxins and toxic shock syndrome toxin, genotyping of chromosomal DNA by pulsed-field gel electrophoresis (PFGE), also amplification and restriction analysis of the coagulase (coa) and the protein A genes (spa) (PCR/restriction fragment length polymorphism (RFLP)) was tested. The results of this study showed that all staphylococcus of phage type 187 belonged to the human biotype (A) and appeared to be sensitive to all of the tested antibiotics, including methicillin (MSSA). Finding out the toxin genes showed that almost all of them (93.8%) had the enterotoxin C gene (sec) and TSST-1 gene (tst). The PFGE typing proved that the phage type 187 strains (except for one) constitute one PFGE type. These results and the identical restriction patterns in the PCR/RFLP method, also the same biotype, sensitivity to antibiotics and the presence genes of the same type of toxins confirmed that the phage type 187 strains constitute one clone within our country. Additionally, the fact that almost all of them have the enterotoxin genes and tst gene allows to consider them the strains of potentially high virulence.

  11. Control of beef spoilage by a sulfide-producing Lactobacillus sake strain with bacteriocinogenic Leuconostoc gelidum UAL187 during anaerobic storage at 2 degrees C.

    PubMed

    Leisner, J J; Greer, G G; Stiles, M E

    1996-07-01

    Chill-stored, vacuum-packaged beef inoculated with sulfide-producing Lactobacillus sake 1218 developed a distinct sulfide odor within 3 weeks of storage at 2 degrees C, at which time the bacteria had reached maximum numbers of 10(6) CFU cm(-2). Coinoculation of the meat with the wild-type, bacteriocinogenic (Bac+) strain of Leuconostoc gelidum UAL187 delayed the spoilage by L. sake 1218 for up to 8 weeks of storage. Coinoculation of meat samples with an isogenic, slowly growing Bac+ variant, UAL187-22, or with the Bac- variant UAL187-13 did not delay the onset of spoilage by L. sake 1218. The study showed that spoilage of chill-stored, vacuum-packaged beef by a susceptible target organism could be dramatically delayed by the Bac+ wild-type strain of L. gelidum UAL187. Inoculation with L. sake 1218 can be used as a model system to determine the efficacy of biopreservation of vacuum-packaged meats.

  12. 18.7 GHz tropospheric scintillation and simultaneous rain attenuation measured at Spino d'Adda and Darmstadt with Italsat

    NASA Astrophysics Data System (ADS)

    Matricciani, Emilio; Riva, Carlo

    2008-02-01

    We present experimental results on the relationship between rain attenuation and simultaneous scintillation, obtained with measurements of attenuation time series at 18.7 GHz, collected in two slant paths to Italsat (13.2° E): at Spino d'Adda (Italy, a 37.7° slant path, times series of 50 samples/s and 1 sample/s) and Darmstadt (Germany, a 32.7° slant path, 1 sample/s). We have found that the average rain attenuation A (dB) and the average standard deviation σm (dB) in 1-min intervals (calculated from the 1 sample/s time series), of the scintillation standard deviation σ (dB), are linked by a power law σm = C3aA?, or by the more refined model σm = C3bA?, that can be due to an effective thin layer of turbulence aloft. The constants C3a,3b can be estimated by applying the ITU-R formula for scintillation predictions. For conservative design, a best fit model of the conditional standard deviation of σ is also provided, as a function of A, as σs = CsAd (dB), where Cs and d are constants.

  13. A 1:8.7 Scale Water Tunnel Verification & Validation Test of an Axial Flow Water Turbine

    SciTech Connect

    Fontaine, Arnold A.; Straka, William A.; Meyer, Richard S.; Jonson, Michael L.

    2014-09-01

    As interest in waterpower technologies has increased over the last few years, there has been a growing need for a public database of measured data for these devices. This would provide a basic understanding of the technology and means to validate analytic and numerical models. Through collaboration between Sandia National Laboratories, Penn State University Applied Research Laboratory, and University of California, Davis, a new marine hydrokinetic turbine rotor was designed, fabricated at 1:8.7-scale, and experimentally tested to provide an open platform and dataset for further study and development. The water tunnel test of this three-bladed, horizontal-axis rotor recorded power production, blade loading, near-wake characterization, cavitation effects, and noise generation. This report documents the small-scale model test in detail and provides a brief discussion of the rotor design and an initial look at the results with comparison against low-order modeling tools. Detailed geometry and experimental measurements are released to Sandia National Laboratories as a data report addendum.

  14. Finnish type of familial amyloidosis: cosegregation of Asp187----Asn mutation of gelsolin with the disease in three large families.

    PubMed Central

    Hiltunen, T; Kiuru, S; Hongell, V; Heliö, T; Palo, J; Peltonen, L

    1991-01-01

    Familial amyloidosis of Finnish type (FAF) is one of the familial amyloidotic polyneuropathy (FAP) syndromes, a group of inherited disorders characterized by extracellular accumulation of amyloid and by clinical symptoms and signs of polyneuropathy. FAF, an autosomal dominant trait, belongs to those rare monogenic disorders which occur with increased frequency in the Finnish population: only single FAF cases have been reported from other populations. In most types of FAP syndromes the accumulating protein is a transthyretin variant. However, recent evidence has suggested that the amyloid peptides in FAF are related to gelsolin, an actin modulating protein. The gelsolin fragments isolated from at least one patient with amyloidosis have been reported to have an amino acid substitution, with asparagine replacing aspartic acid at position 187 of the plasma gelsolin. In this study allele-specific oligonucleotides were used to analyze three large FAF families with multiple affected individuals as well as healthy family members. We found the corresponding G-A mutation in nucleotide 654 of the plasma gelsolin gene to cosegregate with the disease. The result was confirmed by sequencing and strongly suggests that the mutation has caused all the FAF cases of these families. Since the disease is clustered in restricted areas on the southern coast of Finland, this mutation most probably causes the majority, if not all, of FAF cases in Finland. Images Figure 2 PMID:1652889

  15. Confronting "Prop. 187."

    ERIC Educational Resources Information Center

    Lively, Kit

    1995-01-01

    A proposed law barring public social services to illegal immigrants poses a dilemma for California colleges. It calls for state and local agencies, including colleges and universities, to report suspected violators. Opponents see the law as sanctioning racism. Fairness to students and burden on the institutions are major issues. (MSE)

  16. Detection of peripartum myocardial burden by vector-projected 187 channel electrocardiography and serum NT-proBNP.

    PubMed

    Terata, Miyuki; Nakai, Kenji; Fukushima, Akimune; Itoh, Manabu; Kikuchi, Akihiko; Sugiyama, Toru

    2013-01-01

    There is no reliable method of screening for pregnant women at high risk of developing severe myocardial disorders. In this study, we used vector-projected 187 channel electrocardiography (DREAM-ECG) and serum biochemical markers to evaluate peripartum myocardial burden in pregnant women. Forty-one pregnant women were examined at 36-37 weeks gestation (GW36), 7 days postpartum (PPD7), and 1 month postpartum (PPM1). Ten non-pregnant control women were assessed at a single time point. Heart rate, sympathetic index, and repolarization index (RTc dispersion) were quantified using the DREAM-ECG system, and serum levels of NT-proBNP, cardiac troponin T, estrogen, and progesterone were determined. Heart rate and the sympathetic index decreased from GW36 to PPM1 (P = 0.0031). The repolarization index decreased over time and was greater than in non-pregnant controls (31 ± 13 ms). Estrogen and progesterone at PPD7 and PPM1 were significantly lower than those at GW36 (P < 0.0001, P < 0.001). NT-proBNP at PPD7 was greater than at GW36 (median 29 pg/mL at GW36, 86 pg/mL at PPD7), and decreased at PPM1 in comparison to PPD7 (median 18.5 pg/mL). Troponin T was in the normal range during the whole period (< 0.003 ng/mL). In conclusion, these results indicate that the peripartum myocardial burden in pregnant women does not return to normal nonpregnant levels by PPM1. We propose that both repolarization indexes such as RTc dispersion by DREAM-ECG and serum biochemical markers may identify pregnant women at high risk of developing severe myocardial damage in the peripartum period.

  17. Alternating Hemiplegia of Childhood: Retrospective Genetic Study and Genotype-Phenotype Correlations in 187 Subjects from the US AHCF Registry

    PubMed Central

    Viollet, Louis; Glusman, Gustavo; Murphy, Kelley J.; Newcomb, Tara M.; Reyna, Sandra P.; Sweney, Matthew; Nelson, Benjamin; Andermann, Frederick; Andermann, Eva; Acsadi, Gyula; Barbano, Richard L.; Brown, Candida; Brunkow, Mary E.; Chugani, Harry T.; Cheyette, Sarah R.; Collins, Abigail; DeBrosse, Suzanne D.; Galas, David; Friedman, Jennifer; Hood, Lee; Huff, Chad; Jorde, Lynn B.; King, Mary D.; LaSalle, Bernie; Leventer, Richard J.; Lewelt, Aga J.; Massart, Mylynda B.; Mérida, Mario R.; Ptáček, Louis J.; Roach, Jared C.; Rust, Robert S.; Renault, Francis; Sanger, Terry D.; Sotero de Menezes, Marcio A.; Tennyson, Rachel; Uldall, Peter; Zhang, Yue; Zupanc, Mary; Xin, Winnie; Silver, Kenneth; Swoboda, Kathryn J.

    2015-01-01

    Mutations in ATP1A3 cause Alternating Hemiplegia of Childhood (AHC) by disrupting function of the neuronal Na+/K+ ATPase. Published studies to date indicate 2 recurrent mutations, D801N and E815K, and a more severe phenotype in the E815K cohort. We performed mutation analysis and retrospective genotype-phenotype correlations in all eligible patients with AHC enrolled in the US AHC Foundation registry from 1997-2012. Clinical data were abstracted from standardized caregivers’ questionnaires and medical records and confirmed by expert clinicians. We identified ATP1A3 mutations by Sanger and whole genome sequencing, and compared phenotypes within and between 4 groups of subjects, those with D801N, E815K, other ATP1A3 or no ATP1A3 mutations. We identified heterozygous ATP1A3 mutations in 154 of 187 (82%) AHC patients. Of 34 unique mutations, 31 (91%) are missense, and 16 (47%) had not been previously reported. Concordant with prior studies, more than 2/3 of all mutations are clustered in exons 17 and 18. Of 143 simplex occurrences, 58 had D801N (40%), 38 had E815K (26%) and 11 had G937R (8%) mutations. Patients with an E815K mutation demonstrate an earlier age of onset, more severe motor impairment and a higher prevalence of status epilepticus. This study further expands the number and spectrum of ATP1A3 mutations associated with AHC and confirms a more deleterious effect of the E815K mutation on selected neurologic outcomes. However, the complexity of the disorder and the extensive phenotypic variability among subgroups merits caution and emphasizes the need for further studies. PMID:25996915

  18. Variables affecting survival after second primary lung cancer: A population-based study of 187 Hodgkin's lymphoma patients

    PubMed Central

    Milano, Michael T.; Li, Huilin; Constine, Louis S.; Travis, Lois B.

    2012-01-01

    Background Patients successfully treated for Hodgkin's lymphoma (HL) are at known risk for subsequent malignancies, the most common of which is lung cancer. To date, no population-based study has analyzed prognostic variables for overall survival (OS) among HL survivors who developed non-small cell lung cancer (NSCLC). Methods For 187 HL patients who developed NSCLC (among 22,648 HL survivors), we examined the impact of the following variables on OS after NSCLC diagnosis: gender, race, sociodemographic status (based upon county of residence), calendar year and age at NSCLC diagnosis, NSCLC histology and grade, HL stage and subtype, radiation for HL and latency between HL and NSCLC. Patients were grouped by NSCLC stage as follows: localized, regional or distant. All patients were reported to the population-based Surveillance, Epidemiology, and End Results program. For those variables significant on univariate analyses, hazard ratios (HR) were derived from Cox proportional hazards model. Results Sociodemogaphic status, gender and latency between NSCLC and HL did not significantly affect OS of any NSCLC stage group. For patients with localized NSCLC, a history of mixed celluarlity HL was associated with a 3-fold improved OS (P=0.006). For patients with regional NSCLC, prior radiotherapy for HL was associated with a 2-fold worse OS (P=0.025). Conclusions A history of mixed cellularity HL subtype and a history of no radiotherapy for HL are favorable prognostic factors among patients who develop NSCLC. Further research into clinicopathologic and treatment-associated variables potentially affecting OS after second primary NSCLC among HL survivors is warranted. PMID:22295164

  19. Alternating Hemiplegia of Childhood: Retrospective Genetic Study and Genotype-Phenotype Correlations in 187 Subjects from the US AHCF Registry.

    PubMed

    Viollet, Louis; Glusman, Gustavo; Murphy, Kelley J; Newcomb, Tara M; Reyna, Sandra P; Sweney, Matthew; Nelson, Benjamin; Andermann, Frederick; Andermann, Eva; Acsadi, Gyula; Barbano, Richard L; Brown, Candida; Brunkow, Mary E; Chugani, Harry T; Cheyette, Sarah R; Collins, Abigail; DeBrosse, Suzanne D; Galas, David; Friedman, Jennifer; Hood, Lee; Huff, Chad; Jorde, Lynn B; King, Mary D; LaSalle, Bernie; Leventer, Richard J; Lewelt, Aga J; Massart, Mylynda B; Mérida, Mario R; Ptáček, Louis J; Roach, Jared C; Rust, Robert S; Renault, Francis; Sanger, Terry D; Sotero de Menezes, Marcio A; Tennyson, Rachel; Uldall, Peter; Zhang, Yue; Zupanc, Mary; Xin, Winnie; Silver, Kenneth; Swoboda, Kathryn J

    2015-01-01

    Mutations in ATP1A3 cause Alternating Hemiplegia of Childhood (AHC) by disrupting function of the neuronal Na+/K+ ATPase. Published studies to date indicate 2 recurrent mutations, D801N and E815K, and a more severe phenotype in the E815K cohort. We performed mutation analysis and retrospective genotype-phenotype correlations in all eligible patients with AHC enrolled in the US AHC Foundation registry from 1997-2012. Clinical data were abstracted from standardized caregivers' questionnaires and medical records and confirmed by expert clinicians. We identified ATP1A3 mutations by Sanger and whole genome sequencing, and compared phenotypes within and between 4 groups of subjects, those with D801N, E815K, other ATP1A3 or no ATP1A3 mutations. We identified heterozygous ATP1A3 mutations in 154 of 187 (82%) AHC patients. Of 34 unique mutations, 31 (91%) are missense, and 16 (47%) had not been previously reported. Concordant with prior studies, more than 2/3 of all mutations are clusteredin exons 17 and 18. Of 143 simplex occurrences, 58 had D801N (40%), 38 had E815K(26%) and 11 had G947R (8%) mutations [corrected].Patients with an E815K mutation demonstrate an earlier age of onset, more severe motor impairment and a higher prevalence of status epilepticus. This study further expands the number and spectrum of ATP1A3 mutations associated with AHC and confirms a more deleterious effect of the E815K mutation on selected neurologic outcomes. However, the complexity of the disorder and the extensive phenotypic variability among subgroups merits caution and emphasizes the need for further studies.

  20. Neutron capture cross sections of {sup 186}Os, {sup 187}Os, and {sup 189}Os for the Re-Os chronology

    SciTech Connect

    Segawa, M.; Masaki, T.; Nagai, Y.; Temma, Y.; Shima, T.; Mishima, K.; Igashira, M.; Goriely, S.; Koning, A.; Hilaire, S.

    2007-08-15

    Discrete as well as continuum {gamma}-ray energy spectra from the neutron capture by {sup 186}Os, {sup 187}Os, and {sup 189}Os have been taken for the first time at 5{<=}E{sub n}{<=}90 keV by an anti-Compton NaI(Tl) spectrometer. The detection of a weak discrete {gamma}-ray, about 0.5% of total {gamma}-ray strength, demonstrates the high sensitivity of the present measurement. The energy spectra enabled us to accurately determine the reaction cross sections with a small systematic uncertainty. Based on the new cross sections, we reestimate on the basis of a careful reaction cross section calculation the correction factor F{sub {sigma}} for the neutron capture on the 9.75-keV first excited state in {sup 187}Os as a function of stellar temperature, as required to derive the age of the galaxy within the Re-Os chronology.

  1. Photodisintegration cross section measurements on {sup 186}W, {sup 187}Re, and {sup 188}Os: Implications for the Re-Os cosmochronology

    SciTech Connect

    Shizuma, T.; Utsunomiya, H.; Goko, S.; Makinaga, A.; Akimune, H.; Yamagata, T.; Ohta, M.; Mohr, P.; Hayakawa, T.; Ohgaki, H.; Lui, Y.-W.; Toyokawa, H.; Uritani, A.; Goriely, S.

    2005-08-01

    Cross sections of the {sup 186}W, {sup 187}Re, {sup 188}Os({gamma},n) reactions were measured using quasimonochromatic photon beams from laser Compton scattering with average energies from 7.3 to 10.9 MeV. The results are compared with the predictions of Hauser-Feshbach statistical calculations using four different sets of input parameters. In addition, the inverse neutron capture cross sections were evaluated by constraining the model parameters, especially the E1 strength function, on the basis of the experimental data. The present experiment helps to further constrain the correction factor F{sub {sigma}} for the neutron capture on the 9.75 keV state in {sup 187}Os. Implications of F{sub {sigma}} for the Re-Os cosmochronology are discussed with a focus on the uncertainty in the estimate of the age of the galaxy.

  2. Effects of mother lode-type gold mineralization on 187Os/188Os and platinum group element concentrations in peridotite: Alleghany District, California

    USGS Publications Warehouse

    Walker, R.J.; Böhlke, J.K.; McDonough, W.F.; Li, J.

    2007-01-01

    Osmium isotope compositions and concentrations of Re, platinum group elements (PGE), and Au were determined for host peridotites (serpentinites and barzburgites) and hydrothermally altered ultramafic wall rocks associated with Mother Lode-type hydrothermal gold-quartz vein mineralization in the Alleghany district, California. The host peridotites have Os isotope compositions and Re, PGE, and Au abundances typical of the upper mantle at their presumed formation age during the late Proterozoic or early Paleozoic. The hydrothermally altered rocks have highly variable initial Os isotope compositions with ??os, values (% deviation of 187OS/188OS from the chondritic average calculated for the approx. 120 Ma time of mineralization) ranging from -1.4 to -8.3. The lowest Os isotope compositions are consistent with Re depletion of a chondritic source (e.g., the upper mantle) at ca. 1.6 Ga. Most of the altered samples are enriched in Au and have depleted and fractionated abundances of Re and PGE relative to their precursor peridotites. Geoehemical characteristics of the altered samples suggest that Re and some PGE were variably removed from the ultramafic rocks during the mineralization event. In addition to Re, the Pt and Pd abundances of the most intensely altered rocks appear to have been most affected by mineralization. The 187Os-depleted isotopic compositions of some altered rocks are interpreted to be a result of preferential 187Os loss via destruction of Re-rich phases during the event. For these rocks, Os evidently is not a useful tracer of the mineralizing fluids. The results do, however, provide evidence for differential mobility of these elements, and mobility of 187Os relative to the initial bulk Os isotope composition during hydrothermal metasomatic alteration of ultramafic rocks. ?? 2007 Society of Economic Geologists, Inc.

  3. Crystal structure of the S187F variant of human liver alanine: glyoxylate [corrected] aminotransferase associated with primary hyperoxaluria type I and its functional implications.

    PubMed

    Oppici, Elisa; Fodor, Krisztian; Paiardini, Alessandro; Williams, Chris; Voltattorni, Carla Borri; Wilmanns, Matthias; Cellini, Barbara

    2013-08-01

    The substitution of Ser187, a residue located far from the active site of human liver peroxisomal alanine:glyoxylate aminotransferase (AGT), by Phe gives rise to a variant associated with primary hyperoxaluria type I. Unexpectedly, previous studies revealed that the recombinant form of S187F exhibits a remarkable loss of catalytic activity, an increased pyridoxal 5'-phosphate (PLP) binding affinity and a different coenzyme binding mode compared with normal AGT. To shed light on the structural elements responsible for these defects, we solved the crystal structure of the variant to a resolution of 2.9 Å. Although the overall conformation of the variant is similar to that of normal AGT, we noticed: (i) a displacement of the PLP-binding Lys209 and Val185, located on the re and si side of PLP, respectively, and (ii) slight conformational changes of other active site residues, in particular Trp108, the base stacking residue with the pyridine cofactor moiety. This active site perturbation results in a mispositioning of the AGT-pyridoxamine 5'-phosphate (PMP) complex and of the external aldimine, as predicted by molecular modeling studies. Taken together, both predicted and observed movements caused by the S187F mutation are consistent with the following functional properties of the variant: (i) a 300- to 500-fold decrease in both the rate constant of L-alanine half-transamination and the kcat of the overall transamination, (ii) a different PMP binding mode and affinity, and (iii) a different microenvironment of the external aldimine. Proposals for the treatment of patients bearing S187F mutation are discussed on the basis of these results.

  4. Nuclear magnetization distribution radii determined by hyperfine transitions in the 1s level of H-like ions 185Re74+ and 187Re74+

    NASA Astrophysics Data System (ADS)

    Crespo López-Urrutia, J. R.; Beiersdorfer, P.; Widmann, K.; Birkett, B. B.; Mårtensson-Pendrill, A.-M.; Gustavsson, M. G. H.

    1998-02-01

    The F=3 to F=2 hyperfine transitions in the 1s ground state of the two isotopes 185Re74+ and 187Re74+ were measured to be (4560.5+/-3) Å and (4516.9+/-3) Å, respectively, using emission spectroscopy in an electron beam ion trap. After applying appropriate corrections for the nuclear charge distribution and QED effects, a Bohr-Weisskopf effect of ɛ=2.23(9)% and 2.30(9)% are found for 185Re and 187Re, respectively. This value is almost twice that of a previous theoretical estimate, and indicates a distribution of the nuclear magnetization far more extended than that of the nuclear charge. A radius of the magnetization distribution of 1/2=7.57(32) fm and 1/2=7.69(32) fm for 185Re and 187Re, respectively, is inferred from the data. These radii are larger than the nuclear charge distribution radius [1/2=5.39(1) fm] for both isotopes by factors 1.40(6) and 1.43(6), respectively. We find that the Bohr-Weisskopf effect in H-like ions is a sensitive probe of nuclear magnetization distribution, especially for cases where the charge distribution and magnetic moments are accurately known.

  5. Facile solvothermal synthesis of highly active and robust Pd1.87Cu0.11Sn electrocatalyst towards direct ethanol fuel cell applications

    NASA Astrophysics Data System (ADS)

    Jana, Rajkumar; Dhiman, Shikha; Peter, Sebastian C.

    2016-08-01

    Ordered intermetallic Pd1.87Cu0.11Sn ternary electrocatalyst has been synthesized by sodium borohydride reduction of precursor salts Pd(acac)2, CuCl2.2H2O and SnCl2 using one-pot solvothermal synthesis method at 220 °C with a reaction time of 24 h. To the best of our knowledge, here for the first time we report surfactant free synthesis of a novel ordered intermetallic ternary Pd1.87Cu0.11Sn nanoparticles. The ordered structure of the catalyst has been confirmed by powder x-ray diffraction, transmission electron microscopy (TEM). Composition and morphology of the nanoparticles have been confirmed through field emission scanning electron microscopy, energy-dispersive spectrometry and TEM. The electrocatalytic activity and stability of the ternary electrocatalyst towards ethanol oxidation in alkaline medium was investigated by cyclic voltammetry and chronoamperometry techniques. The catalyst is proved to be highly efficient and stable upto 500th cycle and even better than commercially available Pd/C (20 wt%) electrocatalysts. The specific and mass activity of the as synthesized ternary catalyst are found to be ∼4.76 and ∼2.9 times better than that of commercial Pd/C. The enhanced activity and stability of the ordered ternary Pd1.87Cu0.11Sn catalyst can make it as a promising candidate for the alkaline direct ethanol fuel cell application.

  6. RNAi-mediated knockdown of mouse melanocortin-4 receptor in vitro and in vivo, using an siRNA expression construct based on the mir-187 precursor

    PubMed Central

    Kato, Minoru; Huang, Yi-Ying; Matsuo, Mina; Takashina, Yoko; Sasaki, Kazuyo; Horai, Yasushi; Juni, Aya; Kamijo, Shin-Ichi; Saigo, Kaoru; Ui-Tei, Kumiko; Tei, Hajime

    2016-01-01

    RNA interference (RNAi) is a powerful tool for the study of gene function in mammalian systems, including transgenic mice. Here, we report a gene knockdown system based on the human mir-187 precursor. We introduced small interfering RNA (siRNA) sequences against the mouse melanocortin-4 receptor (mMc4r) to alter the targeting of miR-187. The siRNA-expressing cassette was placed under the control of the cytomegalovirus (CMV) early enhancer/chicken β-actin promoter. In vitro, the construct efficiently knocked down the gene expression of a co-transfected mMc4r-expression vector in cultured mammalian cells. Using this construct, we generated a transgenic mouse line which exhibited partial but significant knockdown of mMc4r mRNA in various brain regions. Northern blot analysis detected transgenic expression of mMc4r siRNA in these regions. Furthermore, the transgenic mice fed a normal diet ate 9% more and were 30% heavier than wild-type sibs. They also developed hyperinsulinemia and fatty liver as do mMc4r knockout mice. We determined that this siRNA expression construct based on mir-187 is a practical and useful tool for gene functional studies in vitro as well as in vivo. PMID:27725374

  7. SIMS chemical analysis of extended impacts on the leading and trailing edges of LDEF experiment AO187-2

    NASA Technical Reports Server (NTRS)

    Amari, S.; Foote, J.; Simon, Charles G.; Swan, P.; Walker, R. M.; Zinner, E.; Jessberger, E. K.; Lange, G.; Stadermann, F.

    1992-01-01

    The Long Duration Exposure Facility (LDEF) Experiment AO187-2 consisted of 237 capture cells, 120 on the leading edge and 117 on the trailing edge. Each cell was made of polished Ge plates covered with 2.5 micron thick mylar foil at 200 microns from the Ge. Although all leading edge cells and 105 trailing edge cells had lost their plastic covers during flight, optical and electron microscope examination revealed extended impacts in bare cells from either edge that apparently were produced by high velocity projectiles while the plastic foils were still in place. Detailed optical scanning yielded 53 extended impacts on 100 bare cells from the trailing edge that were selected for SIMS chemical analysis. Lateral multi-element ion probe profiles were obtained on 40 of these impacts. Material that can be attributed to the incoming projectiles was found in all analyzed extended compact features and most seem to be associated with cosmic dust particles. However, LDEF deposits are systematically enriched in the refractory elements Al, Ca, and Ti relative to Mg and Fe when compared to IDP's collected in the stratosphere and to chondritic compositions. These differences are most likely due to elemental fractionation effects during the high velocity impact but real differences between interplanetary particles captured on LDEF and stratospheric IDP's cannot be excluded. Recently we extended our studies to cells from the leading edge and the covered cells from the trailing edge. The 12 covered cells contain 20 extended impact candidates. Ion probe analysis of 3 yielded results similar to those obtained for impacts on the bare cells from the trailing edge. Optical scanning of the bare leading edge cell also reveals many extended impacts (42 on 22 cells scanned to date), demonstrating that the cover foils remained intact at least for some time. However, SIMS analysis showed elements that can reasonably be attributed to micrometeoroids in only 2 out of 11 impacts. Eight impacts

  8. The NQO1 polymorphism C609T (Pro187Ser) and cancer susceptibility: a comprehensive meta-analysis

    PubMed Central

    Lajin, B; Alachkar, A

    2013-01-01

    Background: Evidence is increasingly emerging about multiple roles for the NAD(P)H quinone oxidoreductase 1 enzyme in cancer. The C609T (rs1800566, Pro187Ser) null polymorphism of the NQO1 gene contributes significantly to the variation in enzymatic activity across different populations. NQO1 C609T polymorphism was thoroughly investigated with respect to cancer susceptibility. The results were inconsistent partly due to low sample sizes. The aim of the present work was to perform a meta-analysis to assess association for all common cancer sites separately and in combination. Methods: Our meta-analysis involved 92 studies including 21 178 cases and 25 157 controls. Statistical analysis involved individual cancer sites and the combined cancer risk. Association was tested under different genetic models. Results: We found a statistically significant association between the variant T allele and overall cancer risk in the worldwide population (for the TT vs CC model, OR=1.18 (1.07–1.31), P=0.002, I2=36%). Stratified analysis revealed that this association was largely attributed to the Caucasian ethnicity (for the TT vs CC model, OR=1.28 (1.12–1.46), P=0.0002, I2=1%). Stratification by tumour site showed significant association for bladder cancer in the worldwide population (for the TT vs CC model, OR=1.70 (1.17–2.46), P=0.005, I2=0%), and in the Asian population (for the TT vs CC model, 1.48 (1.14–1.93), P=0.003, I2=16%). Positive association was also found for gastric cancer in the worldwide population under the dominant model (OR=1.34 (1.09–1.65), P=0.006, I2=15%). Conclusion: Our results indicate that the C609T polymorphism of the NQO1 gene is an important genetic risk factor in cancer. PMID:23860519

  9. Synthesis and evaluation of bombesin derivatives on the basis of pan-bombesin peptides labeled with indium-111, lutetium-177, and yttrium-90 for targeting bombesin receptor-expressing tumors.

    PubMed

    Zhang, Hanwen; Chen, Jianhua; Waldherr, Christian; Hinni, Karin; Waser, Beatrice; Reubi, Jean Claude; Maecke, Helmut R

    2004-09-15

    Bombesin receptors are overexpressed on a variety of human tumors like prostate, breast, and lung cancer. The aim of this study was to develop radiolabeled (Indium-111, Lutetium-177, and Yttrium-90) bombesin analogues with affinity to the three bombesin receptor subtypes for targeted radiotherapy. The following structures were synthesized: diethylenetriaminepentaacetic acid-gamma-aminobutyric acid-[D-Tyr6, beta-Ala11, Thi13, Nle14] bombesin (6-14) (BZH1) and 1,4,7,10-tetraazacyclododecane-N,N',N",N"' -tetraacetic acid-gamma-aminobutyric acid-[D-Tyr6, beta-Ala11, Thi13, Nle14] bombesin (6-14) (BZH2). [111In]-BZH1 and in particular [90Y]-BZH2 were shown to have high affinity to all three human bombesin receptor subtypes with binding affinities in the nanomolar range. In human serum metabolic cleavage was found between beta-Ala11 and His12 with an approximate half-life of 2 hours. The metabolic breakdown was inhibited by EDTA and beta-Ala11-His12 (carnosine) indicating that carnosinase is the active enzyme. Both 111In-labeled peptides were shown to internalize into gastrin-releasing peptide-receptor-positive AR4-2J and PC-3 cells with similar high rates, which were independent of the radiometal. The biodistribution studies of [111In]-BZH1 and [111In]-BZH2 ([177Lu]-BZH2) in AR4-2J tumor-bearing rats showed specific and high uptake in gastrin-releasing peptide-receptor-positive organs and in the AR4-2J tumor. A fast clearance from blood and all of the nontarget organs except the kidneys was found. These radiopeptides were composed of the first pan-bombesin radioligands, which show great promise for the early diagnosis of tumors bearing not only gastrin-releasing peptide-receptors but also the other two bombesin receptor subtypes and may be of use in targeted radiotherapy of these tumors.

  10. Function and stability of human transcobalamin II: role of intramolecular disulfide bonds C98-C291 and C147-C187.

    PubMed

    Kalra, Seema; Li, Ning; Seetharam, Shakuntla; Alpers, David H; Seetharam, Bellur

    2003-07-01

    The current studies have investigated the role of three disulfide bonds of human transcobalamin II (TC II), a plasma transporter of cobalamin (Cbl; vitamin B12), in its function and stability. When translated in vitro in the presence or absence of microsomal vesicles, TC II constructs with a single substitution, C3S or C249S, demonstrated synthesis of a stable functional protein. However, TC II synthesized in the presence of microsomal vesicles using constructs with a single (C98S, C147S, C187S, C291S), double (C3/147/S, C98/147/S) or triple (C3/98/147/S) substitution was unstable. In the absence of microsomal vesicles, the percentage of binding to Cbl-Sepharose matrix by TC II expressed by constructs C3S, C3/147/S, C98/147/S, or C3/98/147/S was 100, 49, 52, and 35%, respectively. Upon their reductive alkylation, the binding of TC II expressed by these constructs was reduced to approximately 25-30%. TC II constructs C3S or C249S, when expressed in TC II-deficient fibroblasts, produced a stable functional protein, but those expressed by constructs C147S, C187S, C291S, C3/147/S, C98/147/S, or C3/98/147/S were rapidly degraded. The intracellular degradation of TC II expressed by these constructs was inhibited by lactacystin or MG-132 but not by the lysosomal degradation inhibitors ammonium chloride or chloroquine. These studies suggest that optimal binding of Cbl by human TC II is supported by disulfide bonds C98-C291 and C147-C187 and that their disruption results in loss of Cbl binding and their rapid degradation by the proteasomal machinery.

  11. Neutron physics of the Re/Os clock. I. Measurement of the (n,gamma) cross sections of {sup 186,187,188}Os at the CERN n{sub T}OF facility

    SciTech Connect

    Mosconi, M.; Kaeppeler, F.; Audouin, L.; Dillmann, I.; Heil, M.; Plag, R.; Voss, F.; Walter, S.; Wisshak, K.; Fujii, K.; Abbondanno, U.; Belloni, F.; Milazzo, P. M.; Moreau, C.; Mengoni, A.; Domingo-Pardo, C.; Aerts, G.; Andriamonje, S.; Berthoumieux, E.; Dridi, W.

    2010-07-15

    The precise determination of the neutron capture cross sections of {sup 186}Os and {sup 187}Os is important to define the s-process abundance of {sup 187}Os at the formation of the solar system. This quantity can be used to evaluate the radiogenic component of the abundance of {sup 187}Os due to the decay of the unstable {sup 187}Re (t{sub 1/2}=41.2 Gyr) and from this to infer the time duration of the nucleosynthesis in our galaxy (Re/Os cosmochronometer). The neutron capture cross sections of {sup 186}Os, {sup 187}Os, and {sup 188}Os have been measured at the CERN n{sub T}OF facility from 1 eV to 1 MeV, covering the entire energy range of astrophysical interest. The measurement has been performed by time-of-flight technique using isotopically enriched samples and two C{sub 6}D{sub 6} scintillation detectors for recording the prompt gamma rays emitted in the capture events. Maxwellian averaged capture cross sections have been determined for thermal energies between kT=5 and 100 keV corresponding to all possible s-process scenarios. The estimated uncertainties for the values at 30 keV are 4.1, 3.3, and 4.7% for {sup 186}Os, {sup 187}Os, and {sup 188}Os, respectively.

  12. Neutron physics of the Re/Os clock. I. Measurement of the (n,γ) cross sections of Os186,187,188 at the CERN n_TOF facility

    NASA Astrophysics Data System (ADS)

    Mosconi, M.; Fujii, K.; Mengoni, A.; Domingo-Pardo, C.; Käppeler, F.; Abbondanno, U.; Aerts, G.; Álvarez-Pol, H.; Alvarez-Velarde, F.; Andriamonje, S.; Andrzejewski, J.; Assimakopoulos, P.; Audouin, L.; Badurek, G.; Baumann, P.; Bečvář, F.; Belloni, F.; Berthoumieux, E.; Bisterzo, S.; Calviani, M.; Calviño, F.; Cano-Ott, D.; Capote, R.; Carrillo de Albornoz, A.; Cennini, P.; Chepel, V.; Chiaveri, E.; Colonna, N.; Cortes, G.; Couture, A.; Cox, J.; Dahlfors, M.; David, S.; Dillmann, I.; Dolfini, R.; Dridi, W.; Duran, I.; Eleftheriadis, C.; Embid-Segura, M.; Ferrant, L.; Ferrari, A.; Ferreira-Marques, R.; Fitzpatrick, L.; Frais-Koelbl, H.; Furman, W.; Gallino, R.; Goncalves, I.; Gonzalez-Romero, E.; Goverdovski, A.; Gramegna, F.; Griesmayer, E.; Guerrero, C.; Gunsing, F.; Haas, B.; Haight, R.; Heil, M.; Herrera-Martinez, A.; Igashira, M.; Isaev, S.; Jericha, E.; Kadi, Y.; Karamanis, D.; Karadimos, D.; Kerveno, M.; Ketlerov, V.; Koehler, P.; Konovalov, V.; Kossionides, E.; Krtička, M.; Lamboudis, C.; Leeb, H.; Lindote, A.; Lopes, I.; Lozano, M.; Lukic, S.; Marganiec, J.; Marques, L.; Marrone, S.; Massimi, C.; Mastinu, P.; Milazzo, P. M.; Moreau, C.; Neves, F.; Oberhummer, H.; Oshima, M.; O'Brien, S.; Pancin, J.; Papachristodoulou, C.; Papadopoulos, C.; Paradela, C.; Patronis, N.; Pavlik, A.; Pavlopoulos, P.; Perrot, L.; Plag, R.; Plompen, A.; Plukis, A.; Poch, A.; Praena, J.; Pretel, C.; Quesada, J.; Rauscher, T.; Reifarth, R.; Rosetti, M.; Rubbia, C.; Rudolf, G.; Rullhusen, P.; Salgado, J.; Sarchiapone, L.; Savvidis, I.; Stephan, C.; Tagliente, G.; Tain, J. L.; Tassan-Got, L.; Tavora, L.; Terlizzi, R.; Vannini, G.; Vaz, P.; Ventura, A.; Villamarin, D.; Vincente, M. C.; Vlachoudis, V.; Vlastou, R.; Voss, F.; Walter, S.; Wendler, H.; Wiescher, M.; Wisshak, K.

    2010-07-01

    The precise determination of the neutron capture cross sections of Os186 and Os187 is important to define the s-process abundance of Os187 at the formation of the solar system. This quantity can be used to evaluate the radiogenic component of the abundance of Os187 due to the decay of the unstable Re187 (t1/2=41.2 Gyr) and from this to infer the time duration of the nucleosynthesis in our galaxy (Re/Os cosmochronometer). The neutron capture cross sections of Os186, Os187, and Os188 have been measured at the CERN n_TOF facility from 1 eV to 1 MeV, covering the entire energy range of astrophysical interest. The measurement has been performed by time-of-flight technique using isotopically enriched samples and two C6D6 scintillation detectors for recording the prompt γ rays emitted in the capture events. Maxwellian averaged capture cross sections have been determined for thermal energies between kT=5 and 100 keV corresponding to all possible s-process scenarios. The estimated uncertainties for the values at 30 keV are 4.1, 3.3, and 4.7% for Os186, Os187, and Os188, respectively.

  13. Neutron cross section measurements using the ORELA: /sup 40/Ar(n,x), /sup 40/Ca(n,x), /sup 22/Ne(n,. gamma. ), /sup 187/Os(n,n') /sup 186/ /sup 187/ /sup 188/Os(n,nn'. gamma. ), the stable tellurium isotopes (n,. gamma. ), and /sup 205/Tl(n,n. gamma. ). Progress report, September 1, 1982-August 31, 1983

    SciTech Connect

    Winters, R.R.

    1983-09-01

    The research performed during this reporting period consisted primarily of (1) measurement, analysis, and publication of the /sup 187/Os(n,n') cross section near 30 keV, (2) measurement and analysis of the /sup 148/ /sup 149/ /sup 159/Sm(n,..gamma..) cross sections, (3) development and publication of a significantly better approximation to the average neutron scattering function as determined by total cross section measurements at the Oak Ridge Electron Linear Accelerator (ORELA), and (4) providing support for the neutron capture facility at ORELA as in the corrections made to the /sup 60/Ni(n,..gamma..) data discussed in a paper included with this report. The major result of the /sup 187/Os(n,n') cross section measurement was the 30 keV average value for that cross section anti sigma/sub nn'/ approx. = 1.5 +- 0.2 b and the implication that the duration of stellar nucleosynthesis, as derived from the /sup 187/Re ..-->.. /sup 187/Os beta decay, is estimated to be (8.9 +- 2.0) x 10/sup 9/ year consistent with an earlier estimate reported by Winters and Macklin. The Sm(n,..gamma..) measurement has already resulted in an estimate of the importance of branching in the s-process in the samarium mass region. We estimate the average neutron density during s-process nucleosynthesis in the vicinity of the solar system to be between less than or equal to (1.1 + 0.7) and (1.1 - 0.6) x 10/sup 8/ neutrons/cm/sup 3/. In the optical model analysis of neutron total cross sections we continue to find that orbital angular momentum dependent well depths are required if the spherical optical model is used to describe the neutron-nucleus interaction at low neutron energies.

  14. Identification of the 187 bp EphA7 Genomic DNA as the Dorsal Midline-Specific Enhancer of the Diencephalon and Mesencephalon

    PubMed Central

    Kim, Yujin; Park, Eunjeong; Park, Soochul

    2015-01-01

    EphA7 is a key molecule in regulating the development of the dien- and mesencephalon. To get insight into the mechanism of how EphA7 gene expression is regulated during the dorsal specification of the dien- and mesencephalon, we investigated the cis-acting regulatory sequence driving EphA7 to the dorsal midline of the dien- and mesencephalon. Transgenic LacZ reporter analysis, using overlapping EphA7 BACs, was used to narrow down the dorsal midline-specific enhancer, revealing the 25.3 kb genomic region as the enhancer candidate. Strikingly, this genomic DNA was located far downstream of the EphA7 transcription start site, +302.6 kb to +327.9 kb. Further enhancer mapping, using comparative genomic analysis and transgenic methods, showed that the 187 bp genomic DNA alone, approximately 305 kb downstream of the EphA7 transcription start site, was sufficient to act as the dorsal midline-specific enhancer of EphA7. Importantly, our results indicate that the 187 bp dorsal midline-specific enhancer is critically regulated by homeobox transcription factors during the development of the dien- and mesencephalon. PMID:26537192

  15. Neutron physics of the Re/Os clock. III. Resonance analyses and stellar (n,gamma) cross sections of {sup 186,187,188}Os

    SciTech Connect

    Fujii, K.; Abbondanno, U.; Belloni, F.; Milazzo, P. M.; Moreau, C.; Mosconi, M.; Kaeppeler, F.; Audouin, L.; Dillmann, I.; Heil, M.; Plag, R.; Voss, F.; Walter, S.; Wisshak, K.; Mengoni, A.; Domingo-Pardo, C.; Aerts, G.; Andriamonje, S.; Berthoumieux, E.; Dridi, W.

    2010-07-15

    Neutron resonance analyses have been performed for the capture cross sections of {sup 186}Os, {sup 187}Os, and {sup 188}Os measured at the n{sub T}OF facility at cern. Resonance parameters have been extracted up to 5, 3, and 8 keV, respectively, using the sammy code for a full R-matrix fit of the capture yields. From these results average resonance parameters were derived by a statistical analysis to provide a comprehensive experimental basis for modeling of the stellar neutron capture rates of these isotopes in terms of the Hauser-Feshbach statistical model. Consistent calculations for the capture and inelastic reaction channels are crucial for the evaluation of stellar enhancement factors to correct the Maxwellian averaged cross sections obtained from experimental data for the effect of thermally populated excited states. These factors have been calculated for the full temperature range of current scenarios of s-process nucleosynthesis using the combined information of the experimental data in the region of resolved resonances and in the continuum. The consequences of this analysis for the s-process component of the {sup 187}Os abundance and the related impact on the evaluation of the time duration of galactic nucleosynthesis via the Re/Os cosmochronometer are discussed.

  16. Neutron physics of the Re/Os clock. III. Resonance analyses and stellar (n,γ) cross sections of Os186,187,188

    NASA Astrophysics Data System (ADS)

    Fujii, K.; Mosconi, M.; Mengoni, A.; Domingo-Pardo, C.; Käppeler, F.; Abbondanno, U.; Aerts, G.; Álvarez-Pol, H.; Alvarez-Velarde, F.; Andriamonje, S.; Andrzejewski, J.; Assimakopoulos, P.; Audouin, L.; Badurek, G.; Baumann, P.; Bečvář, F.; Belloni, F.; Berthoumieux, E.; Bisterzo, S.; Calviani, M.; Calviño, F.; Cano-Ott, D.; Capote, R.; Carrillo de Albornoz, A.; Cennini, P.; Chepel, V.; Chiaveri, E.; Colonna, N.; Cortes, G.; Couture, A.; Cox, J.; Dahlfors, M.; David, S.; Dillmann, I.; Dolfini, R.; Dridi, W.; Duran, I.; Eleftheriadis, C.; Embid-Segura, M.; Ferrant, L.; Ferrari, A.; Ferreira-Marques, R.; Fitzpatrick, L.; Frais-Koelbl, H.; Furman, W.; Gallino, R.; Goncalves, I.; Gonzalez-Romero, E.; Goverdovski, A.; Gramegna, F.; Griesmayer, E.; Guerrero, C.; Gunsing, F.; Haas, B.; Haight, R.; Heil, M.; Herrera-Martinez, A.; Igashira, M.; Isaev, S.; Jericha, E.; Kadi, Y.; Karamanis, D.; Karadimos, D.; Kerveno, M.; Ketlerov, V.; Koehler, P.; Konovalov, V.; Kossionides, E.; Krtička, M.; Lamboudis, C.; Leeb, H.; Lindote, A.; Lopes, I.; Lozano, M.; Lukic, S.; Marganiec, J.; Marques, L.; Marrone, S.; Massimi, C.; Mastinu, P.; Milazzo, P. M.; Moreau, C.; Neves, F.; Oberhummer, H.; Oshima, M.; O'Brien, S.; Pancin, J.; Papachristodoulou, C.; Papadopoulos, C.; Paradela, C.; Patronis, N.; Pavlik, A.; Pavlopoulos, P.; Perrot, L.; Plag, R.; Plompen, A.; Plukis, A.; Poch, A.; Praena, J.; Pretel, C.; Quesada, J.; Rauscher, T.; Reifarth, R.; Rosetti, M.; Rubbia, C.; Rudolf, G.; Rullhusen, P.; Salgado, J.; Sarchiapone, L.; Savvidis, I.; Stephan, C.; Tagliente, G.; Tain, J. L.; Tassan-Got, L.; Tavora, L.; Terlizzi, R.; Vannini, G.; Vaz, P.; Ventura, A.; Villamarin, D.; Vincente, M. C.; Vlachoudis, V.; Vlastou, R.; Voss, F.; Walter, S.; Wendler, H.; Wiescher, M.; Wisshak, K.

    2010-07-01

    Neutron resonance analyses have been performed for the capture cross sections of Os186, Os187, and Os188 measured at the n_TOF facility at cern. Resonance parameters have been extracted up to 5, 3, and 8 keV, respectively, using the sammy code for a full R-matrix fit of the capture yields. From these results average resonance parameters were derived by a statistical analysis to provide a comprehensive experimental basis for modeling of the stellar neutron capture rates of these isotopes in terms of the Hauser-Feshbach statistical model. Consistent calculations for the capture and inelastic reaction channels are crucial for the evaluation of stellar enhancement factors to correct the Maxwellian averaged cross sections obtained from experimental data for the effect of thermally populated excited states. These factors have been calculated for the full temperature range of current scenarios of s-process nucleosynthesis using the combined information of the experimental data in the region of resolved resonances and in the continuum. The consequences of this analysis for the s-process component of the Os187 abundance and the related impact on the evaluation of the time duration of galactic nucleosynthesis via the Re/Os cosmochronometer are discussed.

  17. Mass Analyzed Threshold Ionization of Lutetium Dimer

    NASA Astrophysics Data System (ADS)

    Wu, Lu; Roudjane, Mourad; Liu, Yang; Yang, Dong-Sheng

    2013-06-01

    Lu_2 is produced in a pulsed laser-vaporization metal-cluster source and studied by mass-analyzed threshold ionization (MATI) spectroscopy. The MATI spectrum displays several long progressions from the transitions between various vibrational levels of the neutral and ion electronic states. From the spectrum, the upper limit of the ionization energy of the dimer is determined to be 43996 cm^{-1}, and the vibrational frequencies are measured to be 121 cm^{-1} in the neutral state and 90 cm^{-1} in the ion state. By combining with ab initio calculations at CASPT2 level, the ground state of Lu_2 is identified as ^3Σ_g^-. The ^3Σ_g^- state has an electron configuration of 6sσ_g^25dπ_u^15dπ_u^16sσ_u^2, which is formed by the interactions of two Lu atoms in the ^2D(5d6s^2) ground state. Ionization of the neutral state removes a 5dπ_u bonding electron and yields a ion state with a considerably longer bond distance. Lu_2 has a very different bonding feature from La_2, for which a ^1Σ_g^+ ground state was previously identified with an electron configuration of 5dπ_u^46sσ_g^2 formed by the interactions of two La atoms in the ^4F(5d^26s) excited state. Yang Liu, Lu Wu, Chang-Hua Zhang, Serge A. Krasnokutski, and Dong-Sheng Yang, J. Chem. Phys. 135, 034309 (2011).

  18. Os-186 and Os-187 Enrichments and High-He-3/He-4 sources in the Earth's Mantle: Evidence from Icelandic Picrites

    NASA Technical Reports Server (NTRS)

    Brandon, Alan D.; Graham, David W.; Waight, Tod; Gautason, Bjarni

    2007-01-01

    Picrites from the neovolcanic zones in Iceland display a range in Os-187/Os-188O from 0.1297 to 0.1381 ((gamma)Os = 0.0 to 6.5) and uniform Os-186/Os-188 of 0.1198375+/-32 (2 (sigma)). The value for Os-186/Os-188 is within uncertainty of the present-day value for the primitive upper mantle of 0.1198398+/-16. These Os isotope systematics are best explained by ancient recycled crust or melt enrichment in the mantle source region. If so, then the coupled enrichments displayed in Os-186/Os-188 and Os-187/Os-188 from lavas of other plume systems must result from an independent process, the most viable candidate at present remains core-mantle interaction. While some plumes with high He-3/He-4, such as Hawaii, appear to have been subjected to detectable addition of Os (and possibly He) from the outer core, others such as Iceland do not. A positive correlation between Os-187/Os-188 and He-3/He-4 from 9.6 to 19 RA in Iceland picrites is best modeled as mixtures of 500 Ma or older ancient recycled crust mixed with primitive mantle, creating a hybrid source region that subsequently mixes with the convecting MORB mantle during ascent and melting. This multistage mechanism to explain these isotope systematics is consistent with ancient recycled crust juxtaposed with more primitive, relatively He-rich mantle, in convective isolation from the upper mantle, most likely in the lowermost mantle. This is inconsistent with models that propose random mixing between heterogeneities in the convecting upper mantle as a mechanism to explain the observed isotopic variation in oceanic lavas or models that produce a high He-3/He-4 signature in melt depleted and strongly outgassed, He-poor mantle. Instead these systematics require a deep mantle source to explain the 3He/4He signature in Iceland lavas. The He-3/He-4 of lavas derived from the Iceland plume changed over time, from a maximum of 50 RA at 60 Ma, to approximately 25-27 RA at present. The changes are coupled with distinct

  19. Carriers of the Complex Allele HFE c.[187C>G;340+4T>C] Have Increased Risk of Iron Overload in São Miguel Island Population (Azores, Portugal)

    PubMed Central

    Bulhões, Sara; Brilhante, Maria José; Pereirinha, Tânia; Cabral, Rita; Rego, Ana Catarina; Fraga, Cristina; Miguel, António G.; Brasil, Gracinda; Macedo, Paula; Mota-Vieira, Luisa

    2015-01-01

    Iron overload is associated with acquired and genetic conditions, the most common being hereditary hemochromatosis (HH) type-I, caused by HFE mutations. Here, we conducted a hospital-based case-control study of 41 patients from the São Miguel Island (Azores, Portugal), six belonging to a family with HH type-I pseudodominant inheritance, and 35 unrelated individuals fulfilling the biochemical criteria of iron overload compatible with HH type-I. For this purpose, we analyzed the most common HFE mutations– c.845G>A [p.Cys282Tyr], c.187C>G [p.His63Asp], and c.193A>T [p.Ser65Cys]. Results revealed that the family’s HH pseudodominant pattern is due to consanguineous marriage of HFE-c.845G>A carriers, and to marriage with a genetically unrelated spouse that is a -c.187G carrier. Regarding unrelated patients, six were homozygous for c.845A, and three were c.845A/c.187G compound heterozygous. We then performed sequencing of HFE exons 2, 4, 5 and their intron-flanking regions. No other mutations were observed, but we identified the -c.340+4C [IVS2+4C] splice variant in 26 (74.3%) patients. Functionally, the c.340+4C may generate alternative splicing by HFE exon 2 skipping and consequently, a protein missing the α1-domain essential for HFE/ transferrin receptor-1 interactions. Finally, we investigated HFE mutations configuration with iron overload by determining haplotypes and genotypic profiles. Results evidenced that carriers of HFE-c.187G allele also carry -c.340+4C, suggesting in-cis configuration. This data is corroborated by the association analysis where carriers of the complex allele HFE-c.[187C>G;340+4T>C] have an increased iron overload risk (RR = 2.08, 95% CI = 1.40−2.94, p<0.001). Therefore, homozygous for this complex allele are at risk of having iron overload because they will produce two altered proteins—the p.63Asp [c.187G], and the protein lacking 88 amino acids encoded by exon 2. In summary, we provide evidence that the complex allele HFE-c.[187C

  20. Purification and characterization of two bifunctional chitinases/lysozymes extracellularly produced by Pseudomonas aeruginosa K-187 in a shrimp and crab shell powder medium.

    PubMed Central

    Wang, S L; Chang, W T

    1997-01-01

    Two extracellular chitinases (FI and FII) were purified from the culture supernatant of Pseudomonas aeruginosa K-187. The molecular weights of FI and FII were 30,000 and 32,000, respectively, by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and 60,000 and 30,000, respectively, by gel filtration. The pIs for FI and FII were 5.2 and 4.8, respectively. The optimum pH, optimum temperature, pH stability, and thermal stability of FI were pH 8, 50 degrees C, pH 6 to 9, and 50 degrees C; those of FII were pH 7, 40 degrees C, pH 5 to 10, and 60 degrees C. The activities of both enzymes were activated by Cu2+; strongly inhibited by Mn2+, Mg2+, and Zn2+; and completely inhibited by glutathione, dithiothreitol, and 2-mercaptoethanol. Both chitinases showed lysozyme activity. The purified enzymes had antibacterial and cell lysis activities with many kinds of bacteria. This is the first report of a bifunctional chitinase/lysozyme from a prokaryote. PMID:9023918

  1. 187-gene phylogeny of protozoan phylum Amoebozoa reveals a new class (Cutosea) of deep-branching, ultrastructurally unique, enveloped marine Lobosa and clarifies amoeba evolution.

    PubMed

    Cavalier-Smith, Thomas; Chao, Ema E; Lewis, Rhodri

    2016-06-01

    Monophyly of protozoan phylum Amoebozoa, and subdivision into subphyla Conosa and Lobosa each with different cytoskeletons, are well established. However early diversification of non-ciliate lobose amoebae (Lobosa) is poorly understood. To clarify it we used recently available transcriptomes to construct a 187-gene amoebozoan tree for 30 species, the most comprehensive yet. This robustly places new genus Atrichosa (formerly lumped with Trichosphaerium) within lobosan class Tubulinea, not Discosea as previously supposed. We identified an earliest diverging lobosan clade comprising marine amoebae armoured by porose scaliform cell-envelopes, here made a novel class Cutosea with two pseudopodially distinct new families. Cutosea comprise Sapocribrum, ATCC PRA-29 misidentified as 'Pessonella', plus from other evidence Squamamoeba. We confirm that Acanthamoeba and ATCC 50982 misidentified as Stereomyxa ramosa are closely related. Discosea have a strongly supported major subclade comprising Thecamoebida plus Glycostylida (suborders Dactylopodina, Stygamoebina; Vannellina) phylogenetically distinct from Centramoebida. Stygamoeba is sister to Dactylopodina. Himatismenida are either sister to Centramoebida or deeper branching. Discosea usually appear holophyletic (rarely paraphyletic). Paramoeba transcriptomes include prokinetoplastid Perkinsela-like endosymbiont sequences. Cunea, misidentified as Mayorella, is closer to Paramoeba than Vexillifera within holophyletic Dactylopodina. Taxon-rich site-heterogeneous rDNA trees confirm cutosan distinctiveness, allow improved conosan taxonomy, and reveal previous dictyostelid tree misrooting.

  2. Mutagenesis and modeling of the peroxiredoxin (Prx) complex with the NMR structure of ATP-bound human sulfiredoxin implicate aspartate 187 of Prx I as the catalytic residue in ATP hydrolysis.

    PubMed

    Lee, Duck-Yeon; Park, Sung Jun; Jeong, Woojin; Sung, Ho Jin; Oho, Taena; Wu, Xiongwu; Rhee, Sue Goo; Gruschus, James M

    2006-12-26

    The catalytic cysteine of certain members of the peroxiredoxin (Prx) family can be hyperoxidized to cysteinesulfinic acid during reduction of peroxides. Sulfiredoxin is responsible for the ATP-dependent reduction of cysteinesulfinic acid (SO2H) of hyperoxidized Prx. Here we report the NMR solution structure of human sulfiredoxin (hSrx), both with and without bound ATP, and we model the complex of ATP-bound hSrx with Prx. Binding ATP causes only small changes in the NMR structure of hSrx, and the bound ATP conformation is quite similar to that seen for the previously reported X-ray structure of the ADP-hSrx complex. Although hSrx binds ATP, it does not catalyze hydrolysis by itself and has no catalytic acid residue typical of most ATPase and kinase family proteins. For modeling the complex, the ATP-bound hSrx was docked to hyperoxidized Prx II using EMAP of CHARMM. In the model complex, Asn186 of Prx II (Asp187 of Prx I) is in contact with the hSrx-bound ATP beta- and gamma-phosphate groups. Asp187 of Prx I was mutated to alanine and asparagine, and binding and activity of the mutants with hSrx were compared to those of the wild type. For the D187N mutant, both binding and hydrolysis and reduction activities were comparable to those of the wild type, whereas for D187A, binding was unimpaired but ATP hydrolysis and reduction did not occur. The modeling and mutagenesis analyses strongly implicate Asp187 of Prx I as the catalytic residue responsible for ATP hydrolysis in the cysteinesulfinic acid reduction of Prx by hSrx.

  3. Pacific 187Os/188Os isotope chemistry and U-Pb geochronology: Synchroneity of global Os isotope change across OAE 2

    NASA Astrophysics Data System (ADS)

    Du Vivier, A. D. C.; Selby, D.; Condon, D. J.; Takashima, R.; Nishi, H.

    2015-10-01

    Studies of OAE 2 sections beyond the Atlantic Ocean, Western Interior Seaway (WIS) and European pelagic shelf are limited. Here, we present initial osmium isotope stratigraphy (187Os/188Os-Osi) from two proto-Pacific sites that span the Cenomanian-Turonian boundary interval (CTBI): the Yezo Group (YG) section, Hokkaido, Japan, and the Great Valley Sequence (GVS), California, USA; to evaluate the 187Os/188Os seawater chemistry of the proto-Pacific. Additionally we combine new 206Pb/238U zircon CA-ID-TIMS geochronology from five volcanic tuff horizons of the Yezo Group section to test and facilitate inter-basinal integration with the WIS using radio-isotopically constrained age-depth models for both sections, and quantitatively constrain the absolute timing and duration of events across the CTBI. The YG shows an almost identical Osi profile to that of the WIS, and very similar to that of other sites of the proto-Atlantic and European pelagic oceans (Turgeon and Creaser, 2008; Du Vivier et al., 2014). The characteristics of the Osi profile are radiogenic and heterogeneous (∼0.55-0.85) prior to the OAE 2, and synchronous with the inferred OAE 2 onset the Osi abruptly become unradiogenic and remain relatively homogeneous (∼0.20-0.30) before showing a gradual return to more radiogenic Osi (∼ 0.70) throughout the middle to late OAE 2. A206Pb/238U zircon age of an interbedded tuff (HK017) in the adjacent horizon to the first unradiogenic Osi value constrains the age of the Osi inflection at 94.44 ± 0.14 Ma. This age, including uncertainty, agrees with the interpolated age of the same point in the Osi profile (94.28 ± 0.25 Ma) in the only other dated OAE 2 section, the WIS; indicating a coeval shift in seawater chemistry associated with volcanism at the OAE 2 onset at the levels of temporal resolution (ca. 0.1 Myr). Further, prior to the onset of OAE 2 an enhanced radiogenic inflection in the Osi profile of the YG is correlative, within uncertainty, with a similar

  4. Analysis of LDEF experiment AO187-2 chemical and isotopic measurements of micrometeoroids by secondary ion mass spectrometry. Final report

    SciTech Connect

    Zinner, E.

    1995-11-01

    Experiment AO187-2, that was flown on board the Long Duration Exposure Facility (LDEF), was designed to measure the chemical and isotopic compositions of interplanetary dust impinging on the spacecraft from outer space. Information on the nature and composition of orbital debris was also anticipated. The spacecraft maintained a constant orientation with respect to its velocity vector thereby defining leading and trailing edges that faced respectively into and away from the direction of motion. Arrays of individual capture cells each 80.8 sq cm in size and totaling 237 in number were exposed on both the leading and trailing edges of LDEF. Each cell consisted of a pure Ge target surface slightly separated from a thin (2.5 micrometers) metallized plastic `entrance foil.` The basic concept was that incoming projectiles would penetrate the foil, strike the Ge target plate at high velocity producing a vapor-liquid cloud that would re-deposit material on the underside of the plastic foil. This material would then be analyzed using the sensitive surface analysis technique of Secondary Ion Mass Spectrometry (SIMS). In practice, most of the plastic entrance foils failed during the extended period of orbital exposure probably due to a combination of UV embrittlement, large densities of impact events and (for the leading edge) the effects of atomic oxygen erosion in orbit. However the foils failed gradually and most remained in place on the capture cells for a significant fraction of the duration of the flight. Because most of the impactors were small (less than 10 micrometers) they were heated and dispersed in traversing the entrance foils producing clouds of molten droplets and vapor that produced easily identifiable `extended impacts` on the Ge target plates.

  5. Stable time patterns of railway suicides in Germany: comparative analysis of 7,187 cases across two observation periods (1995–1998; 2005–2008)

    PubMed Central

    2014-01-01

    Background The majority of fatalities on the European Union (EU) railways are suicides, representing about 60% of all railway fatalities. The aim of this study was to compare time patterns of suicidal behaviour on railway tracks in Germany between two observation periods (1995–1998 and 2005–2008) in order to investigate their stability and value in railway suicide prevention. Methods Cases were derived from the National Central Registry of person accidents on the German railway network (STABAG). The association of daytime, weekday and month with the mean number of suicides was analysed applying linear regression. Potential differences by observation period were assessed by adding observation period and the respective interaction terms into the linear regression. A 95% confidence interval for the mean number of suicides was computed using the t distribution. Results A total of 7,187 railway suicides were recorded within both periods: 4,102 (57%) in the first period (1995–1998) and 3,085 (43%) in the second (2005–2008). The number of railway suicides was highest on Mondays and Tuesdays in the first period with an average of 3.2 and 3.5 events and of 2.6 events on both days in the second period. In both periods, railway suicides were more common between 6:00 am and noon, and between 6:00 pm and midnight. Seasonality was only prominent in the period 1995–1998. Conclusions Over the course of two observation periods, the weekday and circadian patterns of railway suicides remained stable. Therefore, these patterns should be an integral part of railway suicide preventive measures, e.g. gatekeeper training courses. PMID:24498876

  6. Platinum group elements and 187Os/ 188Os in a purported impact ejecta layer near the Eifelian-Givetian stage boundary, Middle Devonian

    NASA Astrophysics Data System (ADS)

    Schmitz, Birger; Ellwood, Brooks B.; Peucker-Ehrenbrink, Bernhard; El Hassani, Ahmed; Bultynck, Pierre

    2006-09-01

    A global faunal crisis close to the Eifelian-Givetian stage boundary in the mid-Devonian has been purported to be related to the impact of one or two major extraterrestrial bodies. This was based on unusual mineralogical and chemical features within a distinct composite marl bed, at a level c. 40 cm below the Global Stratotype Section and Point (GSSP) for the Eifelian-Givetian boundary at Jebel Mech Irdane in Morocco. The impact relation has been challenged based partly on the absence of platinum group element data. We present here detailed Ir, Os, Pd and Pt as well as Os isotopic data across the bed at Mech Irdane and from a correlated 10 cm bed at a nearby site, Rich Haroun. Iridium concentrations of 0.13-0.28 ng/g in the beds represent a small enrichment compared to average shale, but Ir/Al ratios are only a factor 1.5-2 higher than background at respective site. Such small enrichments can readily be explained by terrestrial diagenetic processes, and do not require the presence of an extraterrestrial component. On an Al-normalized basis Pd and Pt show weak enrichments, typically a factor 2-4 higher than background. High 187Os/ 188Os ratios, 1.1-3.8, reflect ingrowth of radiogenic Os from Re, which is also evident from Os concentrations of up to 3 ng/g. The platinum group inter-element ratios are clearly non-chondritic. The overall platinum group and trace element (e.g. Co, Ni, As, V) patterns indicate that diagenetic processes at redox fronts have played a crucial role in shaping most element enrichments. If an excess siderophile-rich extraterrestrial component exists in these beds it represents less than 0.2‰ by weight.

  7. Global, Regional, and National Consumption of Sugar-Sweetened Beverages, Fruit Juices, and Milk: A Systematic Assessment of Beverage Intake in 187 Countries

    PubMed Central

    Khatibzadeh, Shahab; Shi, Peilin; Lim, Stephen; Andrews, Kathryn G.; Engell, Rebecca E.; Ezzati, Majid; Mozaffarian, Dariush

    2015-01-01

    Background Sugar-sweetened beverages (SSBs), fruit juice, and milk are components of diet of major public health interest. To-date, assessment of their global distributions and health impacts has been limited by insufficient comparable and reliable data by country, age, and sex. Objective To quantify global, regional, and national levels of SSB, fruit juice, and milk intake by age and sex in adults over age 20 in 2010. Methods We identified, obtained, and assessed data on intakes of these beverages in adults, by age and sex, from 193 nationally- or subnationally-representative diet surveys worldwide, representing over half the world’s population. We also extracted data relevant to milk, fruit juice, and SSB availability for 187 countries from annual food balance information collected by the United Nations Food and Agriculture Organization. We developed a hierarchical Bayesian model to account for measurement incomparability, study representativeness, and sampling and modeling uncertainty, and to combine and harmonize nationally representative dietary survey data and food availability data. Results In 2010, global average intakes were 0.58 (95%UI: 0.37, 0.89) 8 oz servings/day for SSBs, 0.16 (0.10, 0.26) for fruit juice, and 0.57 (0.39, 0.83) for milk. There was significant heterogeneity in consumption of each beverage by region and age. Intakes of SSB were highest in the Caribbean (1.9 servings/day; 1.2, 3.0); fruit juice consumption was highest in Australia and New Zealand (0.66; 0.35, 1.13); and milk intake was highest in Central Latin America and parts of Europe (1.06; 0.68, 1.59). Intakes of all three beverages were lowest in East Asia and Oceania. Globally and within regions, SSB consumption was highest in younger adults; fruit juice consumption showed little relation with age; and milk intakes were highest in older adults. Conclusions Our analysis highlights the enormous spectrum of beverage intakes worldwide, by country, age, and sex. These data are

  8. 186Os-187Os and highly siderophile element abundance systematics of the mantle revealed by abyssal peridotites and Os-rich alloys

    NASA Astrophysics Data System (ADS)

    Day, James M. D.; Walker, Richard J.; Warren, Jessica M.

    2017-03-01

    Abyssal peridotites are oceanic mantle fragments that were recently processed through ridges and represent residues of both modern and ancient melting. To constrain the nature and timing of melt depletion processes, and the composition of the mantle, we report high-precision Os isotope data for abyssal peridotites from three ocean basins, as well as for Os-rich alloys, primarily from Mesozoic ophiolites. These data are complemented by whole-rock highly siderophile element (HSE: Os, Ir, Ru, Pt, Pd, Re), trace- and major-element abundances for the abyssal peridotites, which are from the Southwest Indian (SWIR), Central Indian (CIR), Mid-Atlantic (MAR) and Gakkel Ridges. The results reveal a limited role for melt refertilization or secondary alteration processes in modifying abyssal peridotite HSE compositions. The abyssal peridotites examined have experienced variable melt depletion (2% to >16%), which occurred >0.5 Ga ago for some samples. Abyssal peridotites typically exhibit low Pd/Ir and, combined with high-degrees of estimated total melt extraction, imply that they were relatively refractory residues prior to incorporation into their present ridge setting. Recent partial melting processes and mid-ocean ridge basalt (MORB) generation therefore played a limited role in the chemical evolution of their precursor mantle domains. The results confirm that many abyssal peridotites are not simple residues of recent MORB source melting, having a more complex and long-lived depletion history. Peridotites from the Gakkel Ridge, SWIR, CIR and MAR indicate that the depleted MORB mantle has 186Os/188Os of 0.1198356 ± 21 (2SD). The Phanerozoic Os-rich alloys yield an average 186Os/188Os within uncertainty of abyssal peridotites (0.1198361 ± 20). Melt depletion trends defined between Os isotopes and melt extraction indices (e.g., Al2O3) allow an estimate of the primitive mantle (PM) composition, using only abyssal peridotites. This yields 187Os/188Os (0.1292 ± 25), and 186Os

  9. Platinum Group Elements, 187OS/188OS and 87SR/86SR Isotope Systematics in Depleted Fluid-Modified Mariana Fore-Arc Peridotites

    NASA Astrophysics Data System (ADS)

    Harvey, J.; Savov, I. P.; Shirey, S. B.; Horan, M. F.; Mock, T. D.

    2012-12-01

    The serpentine mud volcanoes of the Izu-Bonin-Mariana (IBM) fore-arc, collected during Ocean Drilling Program Leg 195 [1], contain hard-rock clasts of serpentine sampled from close to the décollement, which separates the down-going Pacific slab from the overlying mantle wedge. These clasts preserve evidence for melt depletion (>25 % melt extraction in many instances) in a sub-arc environment, and extensive (40 - 100%) serpentinization due to subsequent fluid / peridotite interaction, e.g. [2]. Platinum-group element (PGE) abundances are not consistent with melt-depletion alone [3]. Fractionation between I-PGE (Os, Ir, Ru) has resulted in groups of IBM serpentinites with either a high chondrite-normalized Os/Ir ratio (OsN/IrN) or a low OsN/IrN ratio. Similarly, fractionation of P-PGE (Pt, Pd) is marked, and distinguishes the IBM serpentinites from worldwide abyssal peridotites. Interaction with high-pH fluids [4] may have partially oxidized mantle sulphide, the major primary host for PGE in these rocks, leading to partial breakdown to sulphate and the selective redistribution of certain PGE (Os, Ru, Pt), a feature normally associated with sub-aerial weathering [5], but which likely prevails in other oxidizing environments. In particular, the Re-Os systematics of the high (OsN/IrN) IBM serpentinites have been disturbed by the addition of Os. Unlike peridotite xenoliths associated with magmatic regions of subduction zones where subduction-related Os-addition is unequivocally radiogenic and derived from crustal material [6][7], where Os has been added to the IBM serpentinites it is unradiogenic and was most likely derived from within the oceanic mantle. IBM serpentinites therefore preserve osmium isotope ratios that are exclusively sub-chondritic (187Os/188Os ≤ 0.127), as previously reported [8]. These serpentinized peridotites were produced by at least a three-step process: melt depletion, serpentinization, and the mobilization of Os, Ru and Pt to produce low Os

  10. Peridotite xenoliths from the Polynesian Austral and Samoa hotspots: Implications for the destruction of ancient 187Os and 142Nd isotopic domains and the preservation of Hadean 129Xe in the modern convecting mantle

    NASA Astrophysics Data System (ADS)

    Jackson, M. G.; Shirey, S. B.; Hauri, E. H.; Kurz, M. D.; Rizo, H.

    2016-07-01

    The Re-Os systematics in 13 peridotite xenoliths hosted in young (<0.39 myr) rejuvenated lavas from the Samoan island of Savai'i and 8 peridotite xenoliths from 6 to 10 myr old lavas from the Austral island of Tubuai have been examined to evaluate the history of the oceanic mantle in this region. Modal mineralogy, trace element compositions and 187Os/188Os ratios suggest that these peridotites are not cognate or residual to mantle plumes but rather samples of Pacific oceanic lithosphere created at the ridge. Savai'i and Tubuai islands lie along a flow line in the Pacific plate, and provide two snapshots (separated by over 40 Ma in time) of Pacific mantle that originated in the same region of the East Pacific rise. Tubuai xenoliths exhibit 187Os/188Os from 0.1163 to 0.1304, and Savai'i (Samoa) xenoliths span a smaller range from 0.1173 to 0.1284. The 187Os/188Os ratios measured in Tubuai xenoliths are lower than (and show no overlap with) basalts from Tubuai. The 187Os/188Os of the Savai'i xenoliths overlap the isotopic compositions of lavas from the island of Savai'i, but also extend to lower 187Os/188Os than the lavas. 3He/4He measurements of a subset of the xenoliths range from 2.5 to 6.4 Ra for Tubuai and 10.8 to 12.4 Ra for Savai'i. Like abyssal peridotites and xenoliths from oceanic hotspots that sample the convecting mantle, Os isotopes from the Savai'i and Tubuai xenolith suites are relatively unradiogenic, but do not preserve a record of depleted early-formed (Hadean and Archean) mantle domains expected from earlier cycles of ridge-related depletion, continent extraction, or subcontinental lithospheric mantle erosion. The lack of preservation of early-formed, geochemically-depleted Os-isotopic and 142Nd/144Nd domains in the modern convecting mantle contrasts with the preservation of early-formed (early-Hadean) 129Xe/130Xe isotopic heterogeneities in the convecting mantle. This can be explained if the initial isotopic signatures in Re-Os and Sm-Nd systems

  11. X-ray diffuse scattering measurements of chemical short-range order and lattice strains in a highly magnetostrictive Fe0.813Ga0.187alloy in an applied magnetic field

    SciTech Connect

    Du, Y.; Huang, M.; Lograsso, T. A.; McQueeney, R. J.

    2012-06-28

    The rapid growth of the magnetostriction coefficient of ferromagnetic Fe1-xGax alloys that occurs at a composition range from 018.7 at. % Ga alloy and show no dependence on the application of a magnetic field. This negative result sets limits on the role of nanoscale precipitates in magnetostriction.

  12. Turn-on fluorescent chemosensor for determination of lutetium ion.

    PubMed

    Faridbod, F; Sedaghat, M; Hosseini, M; Ganjali, M R; Khoobi, M; Shafiee, A; Norouzi, P

    2015-02-25

    A turn-on fluorescent chemosensor is introduced for the detection of Lu(3+) ion using N-[3-methyl]-2-[pyridine-2-amido] phenyl] pyridine-2-carboxamide (L) molecule. Fluorescent emission intensity of L enhances after binding to Lu(3+) ions in ethanol-water solution (1:9, v/v). The observed enhancement is the result of a strong covalent binding between Lu(3+) ion and L (the binding constant value is 2.0×10(6) mol(-1) L). The proposed optical chemosensor can be applied for the analysis of Lu(3+) ion in a linear range of 3.3×10(-7) to 1.0×10(-5) mol L(-1). The limit of detection was obtained 8.6×10(-7) mol L(-1). The probe exhibits high selectivity toward Lu(3+) ion in comparison with common metal ions. The proposed fluorescent chemosensor was successfully used in the determination of Lu(3+) ion in some water samples.

  13. Lutetium-labelled peptides for therapy of neuroendocrine tumours.

    PubMed

    Kam, B L R; Teunissen, J J M; Krenning, E P; de Herder, W W; Khan, S; van Vliet, E I; Kwekkeboom, D J

    2012-02-01

    Treatment with radiolabelled somatostatin analogues is a promising new tool in the management of patients with inoperable or metastasized neuroendocrine tumours. Symptomatic improvement may occur with (177)Lu-labelled somatostatin analogues that have been used for peptide receptor radionuclide therapy (PRRT). The results obtained with (177)Lu-[DOTA(0),Tyr(3)]octreotate (DOTATATE) are very encouraging in terms of tumour regression. Dosimetry studies with (177)Lu-DOTATATE as well as the limited side effects with additional cycles of (177)Lu-DOTATATE suggest that more cycles of (177)Lu-DOTATATE can be safely given. Also, if kidney-protective agents are used, the side effects of this therapy are few and mild and less than those from the use of (90)Y-[DOTA(0),Tyr(3)]octreotide (DOTATOC). Besides objective tumour responses, the median progression-free survival is more than 40 months. The patients' self-assessed quality of life increases significantly after treatment with (177)Lu-DOTATATE. Lastly, compared to historical controls, there is a benefit in overall survival of several years from the time of diagnosis in patients treated with (177)Lu-DOTATATE. These findings compare favourably with the limited number of alternative therapeutic approaches. If more widespread use of PRRT can be guaranteed, such therapy may well become the therapy of first choice in patients with metastasized or inoperable neuroendocrine tumours.

  14. Lutetium-177 Labeled Bombesin Peptides for Radionuclide Therapy.

    PubMed

    Reynolds, Tamila Stott; Bandari, Rajendra P; Jiang, Zongrun; Smith, Charles J

    2016-01-01

    The rare-earth radionuclides that decay by beta particle (β-) emission are considered to be ideal in the context of targeted radiotherapy. The rare-earth isotopes exist primarily in the 3+ oxidation state and are considered to be hard metal centers, requiring multidentate, hard donor ligands such as the poly(aminocarboxylates) for in vivo kinetic inertness. 177Lu is a rare-earth radionuclide that is produced in moderate specific activity (740 GBq/mg) by direct neutron capture of enriched 176Lu via the 176Lu(n,γ)177Lu nuclear reaction. 177Lu has a half-life of 6.71 d, decays by beta emission (Ebmax = 0.497 MeV), and emits two imagable photons (113keV, 3% and 208kev, 11%). High specific activity, no-carrier-added 177Lu can also be prepared by an indirect neutron capture nuclear reaction on a 176Yb target. Herein, we report upon bombesin (BBN) peptides radiolabeled with 177Lu. The impetus driving many of the research studies that we have described in this review is that the high-affinity gastrin releasing peptide receptor (GRPR, BBN receptor subtype 2, BB2) has been identified in tissue biopsy samples and immortalized cell lines of many human cancers and is an ideal biomarker for targeting early-stage disease. Early on, the ability of GRPR agonists to be rapidly internalized coupled with a high incidence of GRPR expression on various neoplasias was a driving force for the design and development of new diagnostic and therapeutic agents targeting GRP receptor-positive tumors. Recent reports, however, show compelling evidence that radiopharmaceutical design and development based upon antagonist-type ligand frameworks clearly bears reexamination. Last of all, the ability to target multiple biomarkers simultaneously via a heterodimeric targeting ligand has also provided a new avenue to investigate the dual targeting capacity of bivalent radioligands for improved in vivo molecular imaging and treatment of specific human cancers. In this report, we describe recent advances in 177Lu-labeled bombesin peptides for targeted radiotherapy that includes agonist, antagonist, and multivalent cell-targeting agents. In vitro, in vivo translational, and in vivo human clinical investigations are described.

  15. Resonance transition energies and oscillator strengths in lutetium and lawrencium.

    PubMed

    Zou, Yu; Fischer, C Froese

    2002-05-06

    The transition energies and oscillator strengths for nd (2)D(3/2)-(n+1)p (2)P(o)(1/2,3/2) transitions in Lu ( n = 5, Z = 71) and Lr ( n = 6, Z = 103) were calculated with the multiconfiguration Dirac-Hartree-Fock method. The present study confirmed that the ground state of atomic Lr is [Rn]5f(14)7s(2)7p (2)P(o)(1/2). The calculation for Lr required wave function expansions of more than 330 000 configuration states. In Lu, the transition energies, with Breit and QED corrections included, agree with experiment to within 126 cm(-1). In lighter elements, core correlation is usually neglected but was found to be of extreme importance for these heavy elements, affecting the oscillator strengths by a factor of 3 and 2 in Lu and Lr, respectively.

  16. Phonon spectra of terbium-doped lutetium orthophosphates

    NASA Astrophysics Data System (ADS)

    Moura, M. R.; Ayala, A. P.; Guedes, I.; Loong, C.-K.; Boatner, L. A.

    2004-12-01

    Raman spectroscopy has been applied to investigations of the effects of substitutionally replacing Lu by Tb in single crystals of the tetragonal, zircon structure host LuPO4. Room-temperature, polarized Raman spectra of Lu1-xTbxPO4 (x =0, 0.01, 0.1, and 0.12) have been studied. No appreciable changes in the frequencies of the phonons were observed, indicating that the force fields in the LuPO4 lattice are not strongly altered by Tb doping on the Lu site. A discussion of the fluorescence bands and a revised assignment of the LuPO4 vibrations are presented.

  17. Lutetium-177 Labeled Peptides: The European Institute of Oncology Experience.

    PubMed

    Carollo, Angela; Papi, Stefano; Chinol, Marco

    2016-01-01

    Peptide receptor radionuclide therapy (PRRT) using radiolabeled somatostatin analogues has shown encouraging results in various somatostatin receptor positive tumors. Partial remission rates up to 30% have been documented as well as significant improvements in quality of life and survival. This treatment takes advantage of the high specific binding of the radiolabeled peptide to somatostatin receptors overexpressed by the tumors thus being more effective on the tumor cells with less systemic side-effects. The development of macrocyclic chelators conjugated to peptides made possible the stable binding with various radionuclides. In particular 177Lu features favourable physical characteristics with a half-life of 6.7 days, emission of β- with energy of 0.5 MeV for treatment and γ-emissions suitable for imaging. The present contribution describes the learning process achieved at the European Institute of Oncology (IEO) since the first application of 90Y labeled peptides to the therapy of neuroendocrine tumors back in 1997. Continuous improvements led to the preparation of a safe 177Lu labeled peptide for human use. Our learning curve began with the identification of the optimal characteristics of the isotope paying attention to its chemical purity and specific activity along with the optimization of the parameters involved in the radiolabeling procedure. Also the radiation protection issues have been improved along the years and recently more and more attention has been devoted to the pharmaceutical aspects involved in the preparation. The overall issue of the quality has now been completed by drafting an extensive documentation with the goal to deliver a safe and reliable product to our patients.

  18. 187Os/188Os in Spinel Peridotites from Borée, Massif Central, France: Seeing through the Effects of Melt Infiltration in the Sub-continental Lithospheric Mantle

    NASA Astrophysics Data System (ADS)

    Barnett, C. J.; Harvey, J.

    2015-12-01

    The Re-Os isotope system can be used to model the timing of melt extraction in peridotites, although secondary metasomatic processes can obscure primary melt depletion signatures, implying that bulk-rock Os model ages should be treated with caution.1Spinel peridotites from the volcanic Maar de Borée (French Massif Central) have equigranular to protogranular and occasionally poikilitic textures. Their bulk-rock chemistry are consistent with moderate degrees of partial melting, but elevated incompatible trace element ratios (e.g. La/YbN) are indicative of subsequent secondary processes. Petrographic observation reveals no infiltration of host basalt, but melt infiltration unrelated to the host basalt has occurred, most likely within the sub-continental lithospheric mantle prior to entrainment as xenoliths. The peridotites have a mean [Os] concentration of 2.35 ng g-1 and 187Os/188Os values from 0.12081 ± 16 to 0.12639 ± 14 (cf. PUM = 0.1296 ± 00082), with rhenium depletion model ages (TRD) ranging from 0.48 to 1.30 Ga. Silicate melt contains up to 2 orders of magnitude less Os than peridotites3 but the 187Os/188Os of melt infiltrated peridotite can be skewed by the precipitation of immiscible sulfide when an infiltrating melt reaches S-saturation4. The Borée peridotites retain an unradiogenic Os-isotope signature despite silicate melt infiltration; this may be due to primary base metal sulfides enclosed in silicate minerals and therefore protected from interaction with infiltrating melts. TRD of enclosed sulphides should therefore be able to 'see through' any secondary metasomatic events and reveal melt depletion ages significantly older than those obtained from bulk-rock analyses (cf. 4). 1. Rudnick & Walker (2009) Lithos 112S, 1083-1095. 2. Meisel et al. (2001) Geochim Cosmochim Ac 65, 1311-1323. 3. Day, J.M.D. (2013) Chem Geol 341, 50-74. 4. Harvey et al. (2010) Geochim Cosmochim Acta 74, 293-320.

  19. 27 CFR 9.187 - Covelo.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Quadrangle,—Mendocino Co., 7.5 Minute Series, edition of 1967, revised 1994; and (4) Jamison Ridge... straight south-southeast 1.4 miles along Dingman Ridge to the 2,228-foot peak along the section 14 and 15... line, T22N, R12W, Jamison Ridge map; then (18) Proceed straight west-southwest 0.9 mile to BM 2217...

  20. 32 CFR 187.6 - Information requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... utilization facility, as defined in the Atomic Energy Act of 1954, as amended, or a nuclear waste management... business information from disclosure. Export promotion factors includes the concept of not unnecessarily... from disclosure. Export promotion factors includes the concept of not unnecessarily hindering...

  1. 32 CFR 187.6 - Information requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... (Manpower, Reserve Affairs, and Logistics). (5) The activities of the intelligence components utilized by... Defense Intelligence Agency, the National Security Agency, the offices for the collection of specialized intelligence through reconnaissance programs, the Army Office of the Assistant Chief of Staff for...

  2. 21 CFR 133.187 - Semisoft cheeses.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... warmed, is subjected to the action of harmless lactic-acid-producing bacteria or other harmless flavor... phosphatase destruction. A semisoft cheese shall be deemed not to have been made from pasteurized milk if 0.25... optional mold-inhibiting ingredient consisting of sorbic acid, potassium sorbate, sodium sorbate, or...

  3. 21 CFR 133.187 - Semisoft cheeses.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... rennet paste, or other safe and suitable milk-clotting enzyme that produces equivalent curd formation... percent, calculated as anhydrous calcium chloride, of the weight of the milk) is added to set the milk to... added, in such quantity that the weight of the solids of such preparation is not more than 0.1...

  4. 27 CFR 9.187 - Covelo.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Co., 7.5 Minute Series, edition of 1967, revised 1994; (2) Covelo West, California Quadrangle,—Mendocino Co., 7.5 Minute Series, edition of 1967, photoinspected 1973; (3) Covelo East, California Quadrangle,—Mendocino Co., 7.5 Minute Series, edition of 1967, revised 1994; and (4) Jamison...

  5. 33 CFR 117.187 - Petaluma River.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... the channel, the drawtender shall sound two long blasts every minute. When the draw is reopened, the drawtender shall sound three short blasts. (b) The draw of the Petaluma highway bridge at “D” Street, mile...

  6. 33 CFR 117.187 - Petaluma River.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... the channel, the drawtender shall sound two long blasts every minute. When the draw is reopened, the drawtender shall sound three short blasts. (b) The draw of the Petaluma highway bridge at “D” Street, mile...

  7. 33 CFR 117.187 - Petaluma River.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... the channel, the drawtender shall sound two long blasts every minute. When the draw is reopened, the drawtender shall sound three short blasts. (b) The draw of the Petaluma highway bridge at “D” Street, mile...

  8. 27 CFR 44.187 - Shipping containers.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false Shipping containers. 44... Shipping containers. Each shipping case, crate, or other container in which tobacco products, or cigarette... same containers in which they were received from the factory. (72 Stat. 1418, as amended; 26...

  9. 27 CFR 9.187 - Covelo.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... this chapter, “Covelo” is a term of viticultural significance. (b) Approved Maps. The appropriate maps... Survey 1:24,000 scale topographic maps. They are titled: (1) Dos Rios, California Quadrangle,—Mendocino...'s boundaries are defined as follows— (1) Beginning on the Dos Rios map at the intersection of...

  10. 7 CFR 4280.187 - Project eligibility.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...) and usage; its activity profile; and the price per unit of energy (electricity, natural gas, propane... months prior to the EEI project and the projected energy usage after the EEI project shall be the... RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE LOANS AND GRANTS Rural Energy for America...

  11. 7 CFR 4280.187 - Project eligibility.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...) and usage; its activity profile; and the price per unit of energy (electricity, natural gas, propane... months prior to the EEI project and the projected energy usage after the EEI project shall be the... RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE LOANS AND GRANTS Rural Energy for America...

  12. 7 CFR 4280.187 - Project eligibility.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...) and usage; its activity profile; and the price per unit of energy (electricity, natural gas, propane... months prior to the EEI project and the projected energy usage after the EEI project shall be the... RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE LOANS AND GRANTS Rural Energy for America...

  13. 32 CFR 187.1 - Purpose.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... considerations with respect to the environment of places within the United States is set out in 32 CFR part 188... Department of Defense OFFICE OF THE SECRETARY OF DEFENSE ENVIRONMENT ENVIRONMENTAL EFFECTS ABROAD OF MAJOR... requirement for taking account of considerations with respect to actions that do significant harm to...

  14. 47 CFR 87.187 - Frequencies.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... associated land stations. (o) The frequency band 1300-1350 MHz is for surveillance radar stations and... associated with the flight testing of aircraft, missiles, or related major components. This includes... limited to airborne radars and associated airborne beacons. (u) The frequency band 8750-8850 MHz...

  15. 47 CFR 87.187 - Frequencies.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... associated land stations. (o) The frequency band 1300-1350 MHz is for surveillance radar stations and... associated with the flight testing of aircraft, missiles, or related major components. This includes... limited to airborne radars and associated airborne beacons. (u) The frequency band 8750-8850 MHz...

  16. 47 CFR 87.187 - Frequencies.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... associated land stations. (o) The frequency band 1300-1350 MHz is for surveillance radar stations and... associated with the flight testing of aircraft, missiles, or related major components. This includes... limited to airborne radars and associated airborne beacons. (u) The frequency band 8750-8850 MHz...

  17. 47 CFR 87.187 - Frequencies.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... associated land stations. (o) The frequency band 1300-1350 MHz is for surveillance radar stations and... associated with the flight testing of aircraft, missiles, or related major components. This includes... limited to airborne radars and associated airborne beacons. (u) The frequency band 8750-8850 MHz...

  18. 47 CFR 87.187 - Frequencies.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... associated land stations. (o) The frequency band 1300-1350 MHz is for surveillance radar stations and... associated with the flight testing of aircraft, missiles, or related major components. This includes... limited to airborne radars and associated airborne beacons. (u) The frequency band 8750-8850 MHz...

  19. 32 CFR 187.3 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... United States. The territories and possessions of the United States include the Virgin Islands, American Samoa, Wake Island, Midway Island, Guam, Palmyra Island, Johnston Atoll, Navassa Island, and...

  20. 32 CFR 187.3 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... United States. The territories and possessions of the United States include the Virgin Islands, American Samoa, Wake Island, Midway Island, Guam, Palmyra Island, Johnston Atoll, Navassa Island, and...

  1. 32 CFR 187.3 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... United States. The territories and possessions of the United States include the Virgin Islands, American Samoa, Wake Island, Midway Island, Guam, Palmyra Island, Johnston Atoll, Navassa Island, and...

  2. 32 CFR 187.3 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... United States. The territories and possessions of the United States include the Virgin Islands, American Samoa, Wake Island, Midway Island, Guam, Palmyra Island, Johnston Atoll, Navassa Island, and...

  3. 49 CFR 572.187 - Lumbar spine.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...-headform assembly to the Part 572 pendulum test fixture per procedure in § 572.183(b)(2) and as shown in... assembly (175-5506) to 50 ± 5 in-lb; (3) Release the pendulum from a height sufficient to allow it to fall freely to achieve an impact velocity of 6.05 ±0.1 m/s measured at the center of the...

  4. 49 CFR 572.187 - Lumbar spine.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...-headform assembly to the Part 572 pendulum test fixture per procedure in § 572.183(b)(2) and as shown in... assembly (175-5506) to 50 ±5 in-lb; (3) Release the pendulum from a height sufficient to allow it to fall freely to achieve an impact velocity of 6.05 ±0.1 m/s measured at the center of the...

  5. 49 CFR 572.187 - Lumbar spine.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...-headform assembly to the Part 572 pendulum test fixture per procedure in § 572.183(b)(2) and as shown in... assembly (175-5506) to 50 ±5 in-lb; (3) Release the pendulum from a height sufficient to allow it to fall freely to achieve an impact velocity of 6.05 ±0.1 m/s measured at the center of the...

  6. 49 CFR 572.187 - Lumbar spine.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...-headform assembly to the Part 572 pendulum test fixture per procedure in § 572.183(b)(2) and as shown in... assembly (175-5506) to 50 ± 5 in-lb; (3) Release the pendulum from a height sufficient to allow it to fall freely to achieve an impact velocity of 6.05 ±0.1 m/s measured at the center of the...

  7. 49 CFR 572.187 - Lumbar spine.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...-headform assembly to the Part 572 pendulum test fixture per procedure in § 572.183(b)(2) and as shown in... assembly (175-5506) to 50 ±5 in-lb; (3) Release the pendulum from a height sufficient to allow it to fall freely to achieve an impact velocity of 6.05 ±0.1 m/s measured at the center of the...

  8. 21 CFR 133.187 - Semisoft cheeses.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... of identity are not prescribed by other sections of this part. They are made from milk and other... the milk used is not pasteurized, the cheese so made is cured at a temperature of not less than 35 °F for not less than 60 days. (b) Milk, which may be pasteurized or clarified or both, and which may...

  9. 26 CFR 1.187-2 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... equipment means property which: (a) Is electric face equipment (within the meaning of section 305 of the... placed in service in connection with any used electric face equipment which the Secretary of the Interior or the Director of the Bureau of Mines certifies makes such used electric face equipment...

  10. 26 CFR 1.187-2 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... equipment means property which: (a) Is electric face equipment (within the meaning of section 305 of the... placed in service in connection with any used electric face equipment which the Secretary of the Interior or the Director of the Bureau of Mines certifies makes such used electric face equipment...

  11. 14 CFR 61.187 - Flight proficiency.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ..., landings, and go-arounds; (viii) Fundamentals of flight; (ix) Performance maneuvers; (x) Ground reference... seaplane base operations; (vii) Takeoffs, landings, and go-arounds; (viii) Fundamentals of flight; (ix...) Takeoffs, landings, and go-arounds; (ix) Fundamentals of flight; (x) Performance maneuvers; (xi)...

  12. 32 CFR 187.4 - Policy.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... the President by the Constitution and the laws of the United States. The objective of the Order is to further foreign policy and national security interests while at the same time taking into consideration... will take account of environmental considerations when it acts in the global commons in accordance...

  13. 32 CFR 187.4 - Policy.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... the President by the Constitution and the laws of the United States. The objective of the Order is to... be respected, and restraint must be exercised in applying United States laws within foreign nations... Policy Act with respect to the environment outside the United States....

  14. 32 CFR 187.4 - Policy.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... the President by the Constitution and the laws of the United States. The objective of the Order is to... be respected, and restraint must be exercised in applying United States laws within foreign nations... Policy Act with respect to the environment outside the United States....

  15. 27 CFR 9.187 - Covelo.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Survey 1:24,000 scale topographic maps. They are titled: (1) Dos Rios, California Quadrangle,—Mendocino... northwest of Iron Spring, in the southeast quadrant of section 28, T22N, R12W, Jamison Ridge map; then...

  16. 27 CFR 9.187 - Covelo.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Survey 1:24,000 scale topographic maps. They are titled: (1) Dos Rios, California Quadrangle,—Mendocino... northwest of Iron Spring, in the southeast quadrant of section 28, T22N, R12W, Jamison Ridge map; then...

  17. 32 CFR 187.5 - Responsibilities.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Secretary of Defense (International Security Affairs) on significant or sensitive actions or decisions affecting relations with another nation. (b) The Assistant Secretary of Defense (International Security... of Defense (Manpower, Reserve Affairs, and Logistics), for monitoring the continuing cooperation...

  18. 32 CFR 187.5 - Responsibilities.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Secretary of Defense (International Security Affairs) on significant or sensitive actions or decisions affecting relations with another nation. (b) The Assistant Secretary of Defense (International Security... of Defense (Manpower, Reserve Affairs, and Logistics), for monitoring the continuing cooperation...

  19. 21 CFR 133.187 - Semisoft cheeses.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... warmed, is subjected to the action of harmless lactic-acid-producing bacteria or other harmless flavor-producing bacteria, present in such milk or added thereto. Sufficient rennet, rennet paste, extract...

  20. 21 CFR 133.187 - Semisoft cheeses.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... warmed, is subjected to the action of harmless lactic-acid-producing bacteria or other harmless flavor-producing bacteria, present in such milk or added thereto. Sufficient rennet, rennet paste, extract...

  1. 32 CFR 187.3 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... physical environment, and it excludes social, economic, and other environments. Social and economic effects... environment on a large geographic scale or has substantial environmental effects on a more...

  2. 32 CFR 187.6 - Information requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... hearings would not produce a substantial net benefit to those responsible for authorizing or approving the... period and the 30-day period may run concurrently. Not less than 45 days may be allowed for...

  3. 28 CFR 18.7 - Discovery.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    .... (a)(1) At any time after the initiation of the proceeding, the hearing officer may order, by subpoena..., together with all objections made (but not including argument or debate), shall be reduced to writing and...)(1) At any time after the initiation of the appeal, any party may serve upon any other party...

  4. 28 CFR 18.7 - Discovery.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    .... (a)(1) At any time after the initiation of the proceeding, the hearing officer may order, by subpoena..., together with all objections made (but not including argument or debate), shall be reduced to writing and...)(1) At any time after the initiation of the appeal, any party may serve upon any other party...

  5. 32 CFR 187.1 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Department of Defense OFFICE OF THE SECRETARY OF DEFENSE ENVIRONMENT ENVIRONMENTAL EFFECTS ABROAD OF MAJOR... requirement for taking account of considerations with respect to actions that do significant harm to the... of Defense (DoD) officials to be informed and take account of environmental considerations...

  6. Precise Re-Os age and low initial 187Os/188Os for latest Permian black shales from the mid-Norwegian shelf herald the Permo-Triassic extinction

    NASA Astrophysics Data System (ADS)

    Georgiev, S.; Stein, H. J.; Hannah, J. L.; Bingen, B.; Xu, G.; Yang, G.; Zimmerman, A.; Weiss, H. M.

    2009-12-01

    The Permo-Triassic boundary records a profound chemical transition and the largest mass extinction in Earth history. Understanding the causal events requires detailed examination of bio/chemo stratigraphic changes precisely pinned in absolute time. Here we report Re-Os isotopic results for well-defined black shale horizons within the Upper Permian marine succession from the Mid-Norwegian shelf: (1) a high-precision Re-Os depositional age and (2) a record of the changes in the Os isotopic composition of seawater at the onset of the Permo-Triassic extinction. Drill core penetrating a Permian-Triassic turbidite succession on the Trøndelag platform, offshore mid-Norway, provided nine organic rich (~3.5% TOC) shale samples over a ca. 30 cm interval. The Re-Os isochron age associated with these samples is extremely precise (< 1 m.y. uncertainty) at 253 Ma with an MSWD near unity. These data place a precise time pin in the studied section and the presumably correlative onshore exposures of the Ravnefjeld formation in East Greenland, indicating deposition of these shales immediately before the catastrophic changes at the Permo-Triassic boundary. Accompanying the isochron regression is a well-determined initial 187Os/188Os ratio of ca. 0.5, notably lower than seawater in the Lower Triassic (Xu et al. 2009). This Os isotopic composition for latest Permian seawater suggests an increase in mantle (or meteoric) material and/or a markedly reduced supply of eroded continental material heralding the up-coming extinction event. These Permian black shales are considered as alternative or complementary source rocks for some of the oil resources in the Norwegian Sea. Our work confirms geographically extensive Upper Permian black shale across the shelves of East Greenland and Norway, implying a major anoxia at the northern margin of Pangea shortly before the Permo-Triassic mass extinction. Xu et al. (2009) GCA, v. 73, no. 13. p. A1463

  7. Age-related risk of major adverse cardiac event risk and coronary artery disease extent and severity by coronary CT angiography: results from 15 187 patients from the International Multisite CONFIRM Study

    PubMed Central

    Nakazato, Ryo; Arsanjani, Reza; Achenbach, Stephan; Gransar, Heidi; Cheng, Victor Y.; Dunning, Allison; Lin, Fay Y.; Al-Mallah, Mouaz; Budoff, Matthew J.; Callister, Tracy Q.; Chang, Hyuk-Jae; Cademartiri, Filippo; Chinnaiyan, Kavitha; Chow, Benjamin J.W.; DeLago, Augustin; Hadamitzky, Martin; Hausleiter, Joerg; Kaufmann, Philipp; Raff, Gilbert; Shaw, Leslee J.; Villines, Todd; Cury, Ricardo C.; Feuchtner, Gudrun; Kim, Yong-Jin; Leipsic, Jonathon; Berman, Daniel S.; Min, James K.

    2014-01-01

    Aims Prior studies evaluating the prognostic utility of cardiac CT angiography (CCTA) have been largely constrained to an all-cause mortality endpoint, with other cardiac endpoints generally not reported. To this end, we sought to determine the relationship of extent and severity of coronary artery disease (CAD) by CCTA to risk of incident major adverse cardiac events (MACEs) (defined as death, myocardial infarction, and late revascularization). Methods and results We identified subjects without prior known CAD who underwent CCTA and were followed for MACE. CAD by CCTA was defined as none (0% luminal stenosis), mild (1–49% luminal stenosis), moderate (50–69% luminal stenosis), or severe (≥70% luminal stenosis), and ≥50% luminal stenosis was considered as obstructive. CAD severity was judged on per-patient, per-vessel, and per-segment basis. Time to MACE was estimated using univariable and multivariable Cox proportional hazards models. Among 15 187 patients (57 ± 12 years, 55% male), 595 MACE events (3.9%) occurred at a 2.4 ± 1.2 year follow-up. In multivariable analyses, an increased risk of MACE was observed for both non-obstructive [hazard ratio (HR) 2.43, P < 0.001] and obstructive CAD (HR: 11.21, P < 0.001) when compared with patients with normal CCTA. Risk-adjusted MACE increased in a dose–response relationship based on the number of vessels with obstructive CAD ≥50%, with increasing hazards observed for non-obstructive (HR: 2.54, P < 0.001), obstructive one-vessel (HR: 9.15, P < 0.001), two-vessel (HR: 15.00, P < 0.001), or three-vessel or left main (HR: 24.53, P < 0.001) CAD. Among patients stratified by age <65 vs. ≥65 years, older individuals experienced higher risk-adjusted hazards for MACE for non-obstructive, one-, and two-vessel, with similar event rates for three-vessel or left main (P < 0.001 for all) compared with normal individuals age <65. Finally, there was a dose relationship of CAD findings by CCTA and MACE event rates with each

  8. Nocistatin and prepro-nociceptin/orphanin FQ 160-187 cause nociception through activation of Gi/o in capsaicin-sensitive and of Gs in capsaicin-insensitive nociceptors, respectively.

    PubMed

    Inoue, Makoto; Kawashima, Toshiko; Allen, Richard G; Ueda, Hiroshi

    2003-07-01

    Nociceptin/orphanin FQ (N/OFQ), nocistatin, and prepro-N/OFQ 160-187 (C-peptide) are all derived from the same precursor protein. We examine the pharmacological mechanisms of nocistatin- and C-peptide-induced pronociceptive responses in a novel algogenic-induced nociceptive flexion test in mice. The intraplantar (i.pl.) injection of nocistatin- and C-peptide induced pronociceptive responses in a range of 0.01 to 10 or 1 pmol, respectively, which showed 100- to 1000-fold less potent effects than the N/OFQ. The nociceptive effects of both peptides were not affected by 1-[(3R,4R)-1-cyclooctylmethyl-3-hydroxymethyl-4-piperidyl]-3-ethyl-1,3-dihydro-2H-benzimidazole-2-one (J-113397) (i.pl.), an N/OFQ receptor antagonist, indicating that they are mediated by a novel mechanism independent of activation of N/OFQ receptor. Like N/OFQ, nocistatin-induced nociception was abolished by i.pl. injection of pertussis toxin, phospholipase C inhibitor, or CP-99994, a neurokinin 1 receptor antagonist, indicating that nocistatin may elicit nociception through a substance P release from nociceptor endings via activation of Gi/o and phospholipase C. The nociception was abolished by neonatal pretreatment (s.c.) with capsaicin or by i.t. pretreatment with CP-99994, but not MK-801 (i.t.), an N-methyl-d-aspartate receptor antagonist. In contrast, C-peptide-induced nociception was attenuated by the pretreatment with antisense oligodeoxynucleotide for Galphas (i.t.) and with KT-5720 (i.pl.), a cyclic AMP-dependent protein kinase inhibitor, but not with pertussis toxin. The nociception was neither attenuated by neonatal capsaicin nor by i.t. injection with CP-99994, but it was attenuated by i.t. injection with MK-801. These results suggest that nocistatin and C-peptide derived from prepro-N/OFQ stimulate distinct nociceptive fibers through different in vivo signaling mechanisms.

  9. Re-187 Os-187 Isotopic and Highly Siderophile Element Systematics of Group IVB Irons

    NASA Technical Reports Server (NTRS)

    Honesto, J.; McDonough, W. F.; Walker, R. J.; McCoy, T. J.; Ash, R. D.

    2005-01-01

    Study of the magmatic iron meteorite groups permits constraints to be placed on the chemical and isotopic composition of parent bodies, and the timing of, and crystal-liquid fractionation processes involved in the crystallization of asteroidal cores. Here we examine Re-Os isotopic and trace elemental systematics of group IVB irons. Compared to most irons, the irons comprising this group are enriched in some of the most refractory siderophile elements, yet highly-depleted in most volatile siderophile elements. These characteristics have been attributed to processes such as high temperature condensation of precursor materials and oxidation in the parent body. Most recently it has been suggested that both processes may be involved in the chemical complexity of the group. Here, high precision isotopic and highly siderophile element (HSE) concentrations are used to further examine these possible origins, and the crystallization history of the group. In addition, we have begun to assess the possibility of relating certain ungrouped irons with major groups via multi-element, trace element modeling. In a companion abstract, the isotopic and trace element systematics of the ungrouped iron Tishomingo are compared with the IVB irons.

  10. 7 CFR 800.187 - Conflicts of interest

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... of grain; or (iii) borrowing money from banks or other financial institutions on customary terms. (d... spouses, minor children, or blood relatives who reside in their immediate households to acquire any such... child, or blood relative who is a resident of the immediate household of official personnel shall...

  11. 7 CFR 800.187 - Conflicts of interest

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... of grain; or (iii) borrowing money from banks or other financial institutions on customary terms. (d... spouses, minor children, or blood relatives who reside in their immediate households to acquire any such... child, or blood relative who is a resident of the immediate household of official personnel shall...

  12. 7 CFR 800.187 - Conflicts of interest

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... of grain; or (iii) borrowing money from banks or other financial institutions on customary terms. (d... spouses, minor children, or blood relatives who reside in their immediate households to acquire any such... child, or blood relative who is a resident of the immediate household of official personnel shall...

  13. 7 CFR 800.187 - Conflicts of interest

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... of grain; or (iii) borrowing money from banks or other financial institutions on customary terms. (d... spouses, minor children, or blood relatives who reside in their immediate households to acquire any such... child, or blood relative who is a resident of the immediate household of official personnel shall...

  14. 38 CFR 18.7 - Conduct of investigations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    .... The responsible agency official or designee shall from time to time review the practices of recipients... the time for filing is extended by the responsible agency offical or designee. (c) Investigations. The...) Resolution of matters. (1) If an investigation pursuant to paragraph (c) of this section indicates a...

  15. 7 CFR 800.187 - Conflicts of interest

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... courtesies of nominal value in a business or work relationship if the exchange is wholly free of any... implications; and (3) the exchange of the usual courtesies in an obvious family or personal relationship... relationship, rather than a business or work relationship. (c) Conflicts. In addition to the conflicts...

  16. Caveat Emptor: The Head Start Scam. Policy Analysis No. 187.

    ERIC Educational Resources Information Center

    Hood, John

    This report questions the efficacy and utility of the Head Start program by challenging the widely accepted belief that early intervention can prevent future dependence and delinquency. This belief assumes that: (1) sweeping conclusions can be drawn from the study of a few unique preschool programs; (2) children's futures are fundamentally…

  17. Materials Data on VMo (SG:187) by Materials Project

    SciTech Connect

    Kristin Persson

    2016-03-29

    Computed materials data using density functional theory calculations. These calculations determine the electronic structure of bulk materials by solving approximations to the Schrodinger equation. For more information, see https://materialsproject.org/docs/calculations

  18. 49 CFR 192.187 - Vaults: Sealing, venting, and ventilation.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... minimize the formation of combustible atmosphere in the vault or pit; and (3) The ducts must be high enough... explosive mixture might be ignited, and there must be a means for testing the internal atmosphere before... of ignition from reaching the vault atmosphere; or (3) If the vault or pit is ventilated,...

  19. 49 CFR 192.187 - Vaults: Sealing, venting, and ventilation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... minimize the formation of combustible atmosphere in the vault or pit; and (3) The ducts must be high enough... explosive mixture might be ignited, and there must be a means for testing the internal atmosphere before... of ignition from reaching the vault atmosphere; or (3) If the vault or pit is ventilated,...

  20. Interlibrary Loan Trends: Staffing and Organization. SPEC Kit #187.

    ERIC Educational Resources Information Center

    Dearie, Tammie Nickelson, Comp.; Steel, Virginia, Comp.

    Topics related to research library interlibrary loan staffing and organizational structures were explored through a survey conducted by the Systems and Procedures Exchange Center (SPEC) of the Association of Research Libraries. Data gathered from 82 libraries show a very small increase in the number of full-time equivalents in loan units between…

  1. 14 CFR 125.187 - Landing gear: Aural warning device.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... an established approach wing-flap position, whenever the wing flaps are extended beyond the maximum... fully extended and locked. (2) For airplanes without an established approach climb wing-flap position, whenever the wing flaps are extended beyond the position at which landing gear extension is...

  2. 14 CFR 125.187 - Landing gear: Aural warning device.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... an established approach wing-flap position, whenever the wing flaps are extended beyond the maximum... fully extended and locked. (2) For airplanes without an established approach climb wing-flap position, whenever the wing flaps are extended beyond the position at which landing gear extension is...

  3. 14 CFR 125.187 - Landing gear: Aural warning device.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... an established approach wing-flap position, whenever the wing flaps are extended beyond the maximum... fully extended and locked. (2) For airplanes without an established approach climb wing-flap position, whenever the wing flaps are extended beyond the position at which landing gear extension is...

  4. 14 CFR 125.187 - Landing gear: Aural warning device.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... an established approach wing-flap position, whenever the wing flaps are extended beyond the maximum... fully extended and locked. (2) For airplanes without an established approach climb wing-flap position, whenever the wing flaps are extended beyond the position at which landing gear extension is...

  5. 14 CFR 125.187 - Landing gear: Aural warning device.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... an established approach wing-flap position, whenever the wing flaps are extended beyond the maximum... fully extended and locked. (2) For airplanes without an established approach climb wing-flap position, whenever the wing flaps are extended beyond the position at which landing gear extension is...

  6. 14 CFR 21.187 - Issue of multiple airworthiness certification.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Issue of multiple airworthiness... of multiple airworthiness certification. (a) An applicant for an airworthiness certificate in the... certificate, if— (1) He shows compliance with the requirements for each category, when the aircraft is in...

  7. 29 CFR 4.187 - Recovery of underpayments.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... employees for unpaid wages and fringe benefits due them are without legal effect. As stated by the Supreme.... Hedstrom, 8 Wage Hour Cases 302 (N.D. Ill. 1948); Craddock-Terry Shoe Corp., Decision of the Administrator... words to the same effect, the surety-guarantor is jointly liable for underpayments by the contractor...

  8. 29 CFR 4.187 - Recovery of underpayments.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... employees for unpaid wages and fringe benefits due them are without legal effect. As stated by the Supreme.... Hedstrom, 8 Wage Hour Cases 302 (N.D. Ill. 1948); Craddock-Terry Shoe Corp., Decision of the Administrator... words to the same effect, the surety-guarantor is jointly liable for underpayments by the contractor...

  9. 29 CFR 4.187 - Recovery of underpayments.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... employees for unpaid wages and fringe benefits due them are without legal effect. As stated by the Supreme.... Hedstrom, 8 Wage Hour Cases 302 (N.D. Ill. 1948); Craddock-Terry Shoe Corp., Decision of the Administrator... words to the same effect, the surety-guarantor is jointly liable for underpayments by the contractor...

  10. 29 CFR 4.187 - Recovery of underpayments.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... employees for unpaid wages and fringe benefits due them are without legal effect. As stated by the Supreme.... Hedstrom, 8 Wage Hour Cases 302 (N.D. Ill. 1948); Craddock-Terry Shoe Corp., Decision of the Administrator... words to the same effect, the surety-guarantor is jointly liable for underpayments by the contractor...

  11. 29 CFR 4.187 - Recovery of underpayments.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... employees for unpaid wages and fringe benefits due them are without legal effect. As stated by the Supreme.... Hedstrom, 8 Wage Hour Cases 302 (N.D. Ill. 1948); Craddock-Terry Shoe Corp., Decision of the Administrator... words to the same effect, the surety-guarantor is jointly liable for underpayments by the contractor...

  12. 21 CFR 146.187 - Canned prune juice.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... this section; and it may contain added vitamin C in a quantity prescribed by paragraph (b)(3) of this... by weight of the finished food. (3) Vitamin C, in a quantity such that the total vitamin C in each 6... vitamin C is added as provided in paragraph (b)(3) of this section, it shall be designated on the label...

  13. 21 CFR 146.187 - Canned prune juice.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... this section; and it may contain added vitamin C in a quantity prescribed by paragraph (b)(3) of this... by weight of the finished food. (3) Vitamin C, in a quantity such that the total vitamin C in each 6... vitamin C is added as provided in paragraph (b)(3) of this section, it shall be designated on the label...

  14. 21 CFR 146.187 - Canned prune juice.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... this section; and it may contain added vitamin C in a quantity prescribed by paragraph (b)(3) of this... by weight of the finished food. (3) Vitamin C, in a quantity such that the total vitamin C in each 6... vitamin C is added as provided in paragraph (b)(3) of this section, it shall be designated on the label...

  15. 21 CFR 146.187 - Canned prune juice.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... this section; and it may contain added vitamin C in a quantity prescribed by paragraph (b)(3) of this... by weight of the finished food. (3) Vitamin C, in a quantity such that the total vitamin C in each 6... vitamin C is added as provided in paragraph (b)(3) of this section, it shall be designated on the label...

  16. 15 CFR 18.7 - Allowable fees and expenses.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    .... (d) The reasonable cost of any study, analysis, engineering report, test, project, or similar matter... the prevailing rate for similar services, and the study or other matter was necessary for preparation of the applicant's case....

  17. 50 CFR 622.187 - Bag and possession limits.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE FISHERIES OF THE CARIBBEAN, GULF OF MEXICO, AND SOUTH... captain and crew is zero. (6) Red porgy—3. (7) Black sea bass—5. (8) South Atlantic...

  18. 50 CFR 622.187 - Bag and possession limits.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE FISHERIES OF THE CARIBBEAN, GULF OF MEXICO, AND SOUTH... from the South Atlantic EEZ off Florida.) (5) Vermilion snapper—5. (6) Red porgy—3. (7) Black sea...

  19. MicroSIFT Courseware Evaluations (1-87).

    ERIC Educational Resources Information Center

    Holznagel, Donald C., Ed.

    A clearinghouse for information about microcomputer-based educational applications has been established at the Northwest Regional Educational Laboratory (NWREL). The clearinghouse, MicroSIFT (Microcomputer Software and Information for Teachers), is a central project of NWREL's Computer Technology Program. A primary concern has been the development…

  20. 21 CFR 146.187 - Canned prune juice.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... this section; and it may contain added vitamin C in a quantity prescribed by paragraph (b)(3) of this... by weight of the finished food. (3) Vitamin C, in a quantity such that the total vitamin C in each 6... vitamin C is added as provided in paragraph (b)(3) of this section, it shall be designated on the label...

  1. Materials Data on WN2 (SG:187) by Materials Project

    SciTech Connect

    Kristin Persson

    2016-09-03

    Computed materials data using density functional theory calculations. These calculations determine the electronic structure of bulk materials by solving approximations to the Schrodinger equation. For more information, see https://materialsproject.org/docs/calculations

  2. 36 CFR 223.187 - Determinations of unprocessed timber.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... selling standard; and, (ii) A statement by the manufacturer certifying under the penalties provided in... selling standard. (3) Lumber, construction timbers, or cants for remanufacture, except western red cedar... or better, with a maximum cross section of 2,000 square centimeters (310 square inches) for...

  3. 36 CFR 223.187 - Determinations of unprocessed timber.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... selling standard; and, (ii) A statement by the manufacturer certifying under the penalties provided in... selling standard. (3) Lumber, construction timbers, or cants for remanufacture, except western red cedar... or better, with a maximum cross section of 2,000 square centimeters (310 square inches) for...

  4. 36 CFR 223.187 - Determinations of unprocessed timber.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... selling standard; and, (ii) A statement by the manufacturer certifying under the penalties provided in... selling standard. (3) Lumber, construction timbers, or cants for remanufacture, except western red cedar... or better, with a maximum cross section of 2,000 square centimeters (310 square inches) for...

  5. 36 CFR 223.187 - Determinations of unprocessed timber.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... selling standard; and, (ii) A statement by the manufacturer certifying under the penalties provided in... selling standard. (3) Lumber, construction timbers, or cants for remanufacture, except western red cedar... or better, with a maximum cross section of 2,000 square centimeters (310 square inches) for...

  6. 36 CFR 223.187 - Determinations of unprocessed timber.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... generally recognized by the industry as setting a selling standard; and, (ii) A statement by the... setting a selling standard. (3) Lumber, construction timbers, or cants for remanufacture, except western... or better, with a maximum cross section of 2,000 square centimeters (310 square inches) for...

  7. The growth of strontium titanate and lutetium ferrite thin films by molecular-beam epitaxy

    NASA Astrophysics Data System (ADS)

    Brooks, Charles M.

    Included in this work is a range of studies on films of homoeptaxial and heteroepitaxial films of SrTiO3 and the first reported phase-pure films of LuFe2O4. We report the structural properties of homoepitaxial (100) SrTiO3 films grown by reactive molecular-beam epitaxy (MBE). The lattice spacing and x-ray diffraction (XRD) rocking curves of stoichiometric MBEgrown SrTiO3 films are indistinguishable from the underlying SrTiO3 substrates. The effect of off-stoichiometry for both strontium-rich and strontium-poor compositions results in lattice expansion with significant changes to the shuttered reflection high-energy electron diffraction oscillations, XRD, film microstructure, and thermal conductivity. Up to an 80% reduction in Sr(1+x)TiO3 film thermal conductivity is measured for x = -0.1 to 0.5. Significant reduction, from 11.5 to ˜2 W˙m-1K-1, occurs through the formation of Ruddlesden-Popper planar faults. The ability to deposit films with a reduction in thermal conductivity is applicable to thermal barrier coatings and thermoelectrics. Scanning transmission electron microscopy is used to examine the formation of Ruddlesden-Popper planar faults in films with strontium excess. We also show that the band gap of SrTiO3 can be altered by >10% (0.3 eV) by using experimentally realizable biaxial strains providing a new means to accomplish band gap engineering of SrTiO3 and related perovskites. Such band gap manipulation is relevant to applications in solar cells water splitting, transparent conducting oxides, superconductivity, two-dimensional electron liquids, and other emerging oxide electronics. This work also presents the adsorption-controlled growth of single-phase (0001)-oriented epitaxial films of charge ordered multiferroic, LuFe2O4, on (111) MgAl2O4, (111) MgO, and (0001) 6H-SiC substrates in an iron-rich environment at pressures and temperatures where excess iron desorbs from the film surface during growth. Scanning transmission electron microscopy reveals reaction-free film-substrate interfaces. The magnetization increases rapidly below 240 K, consistent with the paramagnetic-to-ferrimagnetic phase transition of bulk LuFe2O4.

  8. Structural and dielectric properties of the lutetium (Lu) and yttrium (Y) doped nickel ferrite

    SciTech Connect

    Ugendar, Kodam Markandeyulu, G.

    2014-04-24

    The structural and dielectric characteristics of NiFe{sub 1.925}R{sub 0.075}O{sub 4} (R=Lu,Y) were investigated. The material crystallize in the cubic inverse spinel phase with a very small amount of RFeO{sub 3} (R=Lu,Y) as the additional phase. Frequency variation of the dielectric constant shows the dispersion that can be modeled with a modified Debye's function, which considers the possibility of more than one ion, contributing to the relaxation. Impedance spectroscopic analysis indicates the different relaxation mechanisms, bulk grain and grain-boundary contributions to the electrical conductivity and capacitance of these materials.

  9. Low temperature XAFS investigation on the lutetium binding changes during the 2-line ferrihydrite alteration process.

    PubMed

    Dardenne, K; Schäfer, T; Lindqvist-Reis, P; Denecke, M A; Plaschke, M; Rothe, J; Kim, J I

    2002-12-01

    The time dependent changes of Lu speciation (used as Am(III) homologue), initially sorbed onto 2-line ferrihydrite at pH 5.9, during tempering (70 degrees C) to stable crystalline transformation products, goethite and hematite, is studied. Microscopies (AFM, SEM), XRD and FTIR spectroscopy confirm transformation to both goethite and hematite, with a predominance of hematite. XRD investigation of another transformation series at pH 8.0 (75 degrees C, [Lu(III)initial] 7 times higher) shows that the cell volume of hematite increases, suggesting the incorporation of Lu in the crystal structure. Extended X-ray absorption fine structure (EXAFS) (pH 5.9 series, 70 degrees C) reveals a shortening of the Lu-O bond distance and an increase in asymmetry of the first shell with increasing tempering time in the intermediate temper time samples. The intensity of the second peak in the Fourier transform (FT) of the EXAFS increases and splits into two components. The EXAFS data of the end product can be modeled well using a hematite-like cluster, with an isotropic expansion of distances to account for incorporation of Lu into the hematite structure. These results demonstrate that the Lu is incorporated in the crystal lattice of the transformation product, as opposed to being occluded or remaining a sorbed species on the surface.

  10. Lutetium-177-labeled gastrin releasing peptide receptor binding analogs: a novel approach to radionuclide therapy.

    PubMed

    Panigone, S; Nunn, A D

    2006-12-01

    Optimization of therapy for individual patients remains a goal of clinical practice. Radionuclide imaging can identify those patients who may benefit from subsequent targeted therapy by providing regional information on the distribution of the target. An ideal situation may be when the imaging and the therapeutic compounds are the same agent. Two antibodies ([ [90Y]ibritumomab, [131I]tositumomab) are now approved for the systemic radiotherapy of non-Hodgkin's lymphoma. The main hurdle is to deliver higher absorbed doses to the more refractory solid tumors paying particular regard to the bone marrow toxicity. The low dose is thought to be a result of the large size of antibodies slowing delivery to the target. Peptides having high affinity to receptors expressed on cancer cells are a promising alternative. They are usually rapidly excreted from the body through renal and/or hepatobiliary excretion thus creating a prolonged accumulation of the radioactivity in the kidneys, which represents a recognized issue for systemic radiotherapy. The first radiopeptide developed was a somatostatin analogue, which led to a major breakthrough in the field. Beside the kidney issue, somatostatin use remains limited to few cancers that express receptors in sufficiently large quantities, mainly neuroendocrine tumors. The gastrin releasing peptide (GRP) receptor is an attractive target for development of new radiopeptides with diagnostic and therapeutic potential. This is based upon the functional expression of GRP receptors in several of the more prevalent cancers including prostate, breast, and small cell lung cancer. This review covers the efforts currently underway to develop new and clinically promising GRP-receptor specific molecules labeled with imageable and therapeutic radionuclides.

  11. Automated module radiolabeling of peptides and antibodies with gallium-68, lutetium-177 and iodine-131.

    PubMed

    De Decker, Mario; Turner, J Harvey

    2012-02-01

    Our objectives were to automate radiolabeling of therapeutic activities for safe, reliable, cost-effective, practical routine preparation of (177)Lu-radiopeptides, (131)I radioimmunotherapeutic agents, and (68)Ga-peptide PET diagnostics and, in particular, minimize radiation exposure to the radiopharmaceutical chemist. Reprogramming and adaptation of a commercially available synthetic module (IBA molecular; Synthera®) allowed high yield, fully automated, in-house radiolabeling of novel therapeutic and diagnostic radiopharmaceuticals under remote shielded sterile conditions. Radiochemical yield and purity was measured by instant thin-layer chromatography and high-performance liquid chromatography. (68)Ga-octreotate and (177)Lu-octreotate were synthesized, resulting in both radiochemical yield and radiochemical purity greater than 99%. Synthesis of (131)I-rituximab resulted in a yield of 60%, with a radiochemical purity greater than 99%. Using 400 MBq (68)GaCl(3) per synthesis, the estimated absorbed body and hand dose for a manual synthesis was 2 and 27 μ Sv, contrasting with automated synthesis exposure of 1.3 and 7.9 μ Sv. Using 8000 MBq (177)LuCl(3) per synthesis, the estimated absorbed body and hand dose for a manual synthesis was 44.7 and 75 μ Sv, contrasting with automated synthesis exposure of 2.5 and 20 μ Sv. Using 6000 MBq (131)I per synthesis, the estimated absorbed body and hand dose for a manual synthesis was 83.7 and 335 μ Sv, contrasting with automated synthesis exposure of 10.9 and 54.7 μ Sv. The reduction in radiation exposure by automated synthesis of radiopharmaceuticals in the Synthera® module was at least five fold. Automated synthesis of therapeutic (177)Lu and (131)I radiopharmaceuticals and (68)Ga PET agents in the shielded sterile Synthera® module is simple, practical, and efficient and virtually eliminates radiation exposure to the radiopharmaceutical chemist.

  12. Transition energies of ytterbium, lutetium, and lawrencium by the relativistic coupled-cluster method

    SciTech Connect

    Eliav, E.; Kaldor, U.; Ishikawa, Y.

    1995-07-01

    The relativistic Fock-space coupled-cluster method was applied to the Yb, Lu, and Lr atoms, and to several of their ions. A large number of transition energies was calculated for these systems. Starting from an all-electron Dirac-Fock or Dirac-Fock-Breit function, many electrons (30--40) were correlated to account for core-valence polarization. High-{ital l} virtual orbitals were included (up to {ital l}=5) to describe dynamic correlation. Comparison with experiment (when available) shows agreement within a few hundred wave numbers in most cases. Fine-structure splittings are even more accurate, within 30 cm{sup {minus}1} of experiment. Average errors are at least three times smaller than for previous calculations. Two bound states of Lu{sup {minus}} are predicted, 6{ital p}5{ital d} {sup 1}{ital D}{sub 2} and 6{ital p}{sup 2} {sup 3}{ital P}{sub 0}, with binding energies of about 2100 and 750 cm{sup {minus}1}, respectively. The ground state of lawrencium is {sup 2}{ital P}{sub 1/2}, relativistically stabilized relative to {sup 2}{ital D}{sub 3/2}, the ground state of Lu. Two states of the Lr{sup {minus}} anion are bound, 7{ital p}{sup 2} {sup 3}{ital P}{sub 0} (by 2500 cm{sup {minus}1}) and 7{ital p}6{ital d} {sup 1}{ital D}{sub 2} (by 1300 cm{sup {minus}1}).

  13. The isolation of lutetium from gadolinium contained in Purex process solutions

    SciTech Connect

    Bostick, D.T.; Vick, D.O.; May, M.P.; Walker, R.L.

    1992-09-01

    A chemical separation procedure has been devised to isolate Lu from Purex dissolver solutions containing the neutron poison, Gd. The isolation procedure involves the removal of U and >Pu from a dissolver solution using tributylphosphate solvent extraction. If required, solvent extraction using di-(2-ethylhexyl) phosphoric acid can be employed to further purify the sample be removing alkali and alkali earth elements. Finally, Lu is chromatographically separated from Gd and rare earth fission products on a Dowex 50W-X8 resin column using an alpha-hydroxyisobutyrate eluant. The success of the chemical separation procedure has been demonstrated in the quantitative recovery of as little as 1.4 ng Lu from solutions containing a 5000-fold excess of Gd. Additionally, Lu has been isolated from synthetic dissolver samples containing U, Ba, Cs, and Gd. Thermal emission MS data indicated that the Lu fraction of the synthetic sample was free of Gd interference.

  14. Production of No-Carrier Added Lutetium-177 by Irradiation of Enriched Ytterbium-176.

    PubMed

    Tarasov, Valery A; Andreev, Oleg I; Romanov, Evgeny G; Kuznetsov, Rostislav A; Kupriyanov, Vladimir V; Tselishchev, Ivan V

    2015-01-01

    Two methods of Lu-177 production are reviewed: irradiation of isotopically enriched Lu- 176 (direct way) and irradiation of ytterbium enriched with Yb-176 (indirect way). Based on neutronphysical calculations Lu-177 yield and specific activity were estimated for both methods. Lu-177 specific activity strongly depends on neutron flux density in the direct way, that is 75,000 Ci/g for 10- days irradiation in a neutron flux of 2.10(15) cm(-2) s(-1), and only 13,000 Ci/g after 30 days irradiation at neutron flux 1.10(14) cm(-2) s(-1). Irradiation of Yb-176 provides Lu-177 specific activity close to theoretical value (110,000 Ci/g). Neutron flux density effect Lu-177 yield, that is 530 Ci/g for 2.1015 cm(-2) s(-1) neutron flux density after 30 days irradiation. A procedure of isolation and purification of Lu-177 from irradiated targets is described based on combination of galvanostatic extraction of ytterbium followed by cation-exchange chromatography from alfa-hydroxyisobutirate solutions on BioRad AG(®)50W-X8 resin.

  15. NEW ABUNDANCE DETERMINATIONS OF CADMIUM, LUTETIUM, AND OSMIUM IN THE r-PROCESS ENRICHED STAR BD +17 3248 {sup ,}

    SciTech Connect

    Roederer, Ian U.; Sneden, Christopher; Lawler, James E.; Cowan, John J.

    2010-05-01

    We report the detection of Cd I (Z = 48), Lu II (Z = 71), and Os II (Z = 76) in the metal-poor star BD +17 3248. These abundances are derived from an ultraviolet spectrum obtained with the Space Telescope Imaging Spectrograph on the Hubble Space Telescope. This is the first detection of these neutron-capture species in a metal-poor star enriched by the r process. We supplement these measurements with new abundances of Mo I, Ru I, and Rh I derived from an optical spectrum obtained with the High Resolution Echelle Spectrograph on Keck. Combined with previous abundance derivations, 32 neutron-capture elements have been detected in BD +17 3248, the most complete neutron-capture abundance pattern in any metal-poor star to date. The light neutron-capture elements (38 {<=} Z {<=} 48) show a more pronounced even-odd effect than expected from current solar system r-process abundance predictions. The age for BD +17 3248 derived from the Th II/Os II chronometer is in better agreement with the age derived from other chronometers than the age derived from Th II/Os I. New Hf II abundance derivations from transitions in the ultraviolet are lower than those derived from transitions in the optical, and the lower Hf abundance is in better agreement with the scaled solar system r-process distribution.

  16. EF5 and Motexafin Lutetium in Detecting Tumor Cells in Patients With Abdominal or Non-Small Cell Lung Cancer

    ClinicalTrials.gov

    2013-01-15

    Advanced Adult Primary Liver Cancer; Carcinoma of the Appendix; Fallopian Tube Cancer; Gastrointestinal Stromal Tumor; Localized Extrahepatic Bile Duct Cancer; Localized Gallbladder Cancer; Localized Gastrointestinal Carcinoid Tumor; Localized Resectable Adult Primary Liver Cancer; Localized Unresectable Adult Primary Liver Cancer; Metastatic Gastrointestinal Carcinoid Tumor; Ovarian Sarcoma; Ovarian Stromal Cancer; Primary Peritoneal Cavity Cancer; Recurrent Adult Primary Liver Cancer; Recurrent Adult Soft Tissue Sarcoma; Recurrent Colon Cancer; Recurrent Extrahepatic Bile Duct Cancer; Recurrent Gallbladder Cancer; Recurrent Gastric Cancer; Recurrent Gastrointestinal Carcinoid Tumor; Recurrent Non-small Cell Lung Cancer; Recurrent Ovarian Epithelial Cancer; Recurrent Ovarian Germ Cell Tumor; Recurrent Pancreatic Cancer; Recurrent Rectal Cancer; Recurrent Small Intestine Cancer; Recurrent Uterine Sarcoma; Regional Gastrointestinal Carcinoid Tumor; Small Intestine Adenocarcinoma; Small Intestine Leiomyosarcoma; Small Intestine Lymphoma; Stage 0 Non-small Cell Lung Cancer; Stage I Adult Soft Tissue Sarcoma; Stage I Colon Cancer; Stage I Gastric Cancer; Stage I Non-small Cell Lung Cancer; Stage I Ovarian Epithelial Cancer; Stage I Ovarian Germ Cell Tumor; Stage I Pancreatic Cancer; Stage I Rectal Cancer; Stage I Uterine Sarcoma; Stage II Adult Soft Tissue Sarcoma; Stage II Colon Cancer; Stage II Gastric Cancer; Stage II Non-small Cell Lung Cancer; Stage II Ovarian Epithelial Cancer; Stage II Ovarian Germ Cell Tumor; Stage II Pancreatic Cancer; Stage II Rectal Cancer; Stage II Uterine Sarcoma; Stage III Adult Soft Tissue Sarcoma; Stage III Colon Cancer; Stage III Gastric Cancer; Stage III Ovarian Epithelial Cancer; Stage III Ovarian Germ Cell Tumor; Stage III Pancreatic Cancer; Stage III Rectal Cancer; Stage III Uterine Sarcoma; Stage IIIA Non-small Cell Lung Cancer; Stage IIIB Non-small Cell Lung Cancer; Stage IV Adult Soft Tissue Sarcoma; Stage IV Colon Cancer; Stage IV Gastric Cancer; Stage IV Non-small Cell Lung Cancer; Stage IV Ovarian Epithelial Cancer; Stage IV Ovarian Germ Cell Tumor; Stage IV Pancreatic Cancer; Stage IV Rectal Cancer; Stage IV Uterine Sarcoma; Unresectable Extrahepatic Bile Duct Cancer; Unresectable Gallbladder Cancer

  17. Extraction of lutetium(III) from aqueous solutions by employing a single fibre-supported liquid membrane.

    PubMed

    Trtić-Petrović, Tatjana M; Kumrić, Ksenija R; Dordević, Jelena S; Vladisavljević, Goran T

    2010-07-01

    Transport behaviour of Lu(III) across a polypropylene hollow fibre-supported liquid membrane containing di(2-ethylhexyl)phosphoric acid (DEHPA) in dihexyl ether as a carrier has been studied. The donor phase was LuCl(3) in the buffer solution consisting of 0.2 M sodium acetate at pH 2.5-5.0. A miniaturised system with a single hollow fibre has been operated in a batch mode. The concentration of Lu(III) was determined by indirect voltammetric method using Zn-EDTA complex. The effect of pH and volume of the donor phase, DEHPA concentration in the organic (liquid membrane) phase, the time of extraction and the content of the acceptor phase on the Lu(III) extraction and stripping behaviour was investigated. The results were discussed in terms of the pertraction and removal efficiency, the memory effect and the mean flux of Lu(III). The optimal conditions for the removal of (177)Lu(III) from labelled (177)Lu-radiopharmaceuticals were discussed and identified. The removal efficiency of Lu(III) greater than 99% was achieved at pH of the donor phase between 3.5 and 5.0 using DEHPA concentration in the organic phase of 0.47 M and the ratio of the donor to the acceptor phase of 182.

  18. Electronic structure of interstitial hydrogen in lutetium oxide from DFT+U calculations and comparison study with μ SR spectroscopy

    NASA Astrophysics Data System (ADS)

    da Silva, E. Lora; Marinopoulos, A. G.; Vieira, R. B. L.; Vilão, R. C.; Alberto, H. V.; Gil, J. M.; Lichti, R. L.; Mengyan, P. W.; Baker, B. B.

    2016-07-01

    The electronic structure of hydrogen impurity in Lu2O3 was studied by first-principles calculations and muonium spectroscopy. The computational scheme was based on two methods which are well suited to treat defect calculations in f -electron systems: first, a semilocal functional of conventional density-functional theory (DFT) and secondly a DFT+U approach which accounts for the on-site correlation of the 4 f electrons via an effective Hubbard-type interaction. Three different types of stable configurations were found for hydrogen depending upon its charge state. In its negatively charged and neutral states, hydrogen favors interstitial configurations residing either at the unoccupied sites of the oxygen sublattice or at the empty cube centers surrounded by the lanthanide ions. In contrast, the positively charged state stabilized only as a bond configuration, where hydrogen binds to oxygen ions. Overall, the results between the two methods agree in the ordering of the formation energies of the different impurity configurations, though within DFT+U the charge-transition (electrical) levels are found at Fermi-level positions with higher energies. Both methods predict that hydrogen is an amphoteric defect in Lu2O3 if the lowest-energy configurations are used to obtain the charge-transition, thermodynamic levels. The calculations of hyperfine constants for the neutral interstitial configurations show a predominantly isotropic hyperfine interaction with two distinct values of 926 MHz and 1061 MHz for the Fermi-contact term originating from the two corresponding interstitial positions of hydrogen in the lattice. These high values are consistent with the muonium spectroscopy measurements which also reveal a strongly isotropic hyperfine signature for the neutral muonium fraction with a magnitude slightly larger (1130 MHz) from the ab initio results (after scaling with the magnetic moments of the respective nuclei).

  19. Lutetium incorporation in magmas at depth: Changes in melt local environment and the influence on partitioning behaviour

    NASA Astrophysics Data System (ADS)

    de Grouchy, Charlotte J. L.; Sanloup, Chrystèle; Cochain, Benjamin; Drewitt, James W. E.; Kono, Yoshio; Crépisson, Céline

    2017-04-01

    The structure of two Lu doped (4000 ppm) model end member silicate liquids, a highly polymerised haplogranite (Si-Al-Na-K-O) and a less polymerised anorthite-diopside (Si-Al-Mg-Ca-O), have been studied up to 8 GPa using in situ x-ray diffraction techniques. The results are the first to identify trace rare Earth element incorporation in silicate melts at high pressure. At pressures below 5 GPa, the bonding environment of Lu-O was found to be dependent on composition with coordination number CNLu-O = 8 and bond distance rLu-O = 2.36 Å in the haplogranite melt, decreasing to CNLu-O = 6 and rLu-O = 2.29 Å in the anorthite-diopside melt. This compositional variance in coordination number at low pressure is consistent with observations made for Y-O in glasses at ambient conditions and is coincident with a dramatic increase in the partition coefficients previously observed for rare Earth elements with increasing melt polymerisation. With increasing pressure we find that CNLu-O and rLu-O remain constant in the haplogranite melt. However, an abrupt change in both Lu-O coordination and bond distance is observed at 5 GPa in the anorthite-diopside melt, with CNLu-O increasing from 6 to 8-fold and rLu-O from 2.29 to 2.39 Å. This occurs over a similar pressure range where a change in the P-dependence in the reported rare Earth element partition coefficients is observed for garnet-, clinopyroxene-, and olivine-melt systems. This work shows that standard models for predicting trace elements at depth must incorporate the effect of pressure-induced structural transformations in the melt in order to realistically predict partitioning behaviour.

  20. Lanthanum(III) and Lutetium(III) in Nitrate-Based Ionic Liquids: A Theoretical Study of Their Coordination Shell.

    PubMed

    Bodo, Enrico

    2015-09-03

    By using ab initio molecular dynamics, we investigate the solvent shell structure of La(3+) and Lu(3+) ions immersed in two ionic liquids, ethylammonium nitrate (EAN) and its hydroxy derivative (2-ethanolammonium nitrate, HOEAN). We provide the first study of the coordination properties of these heavy metal ions in such a highly charged nonacqueous environment. We find, as expected, that the coordination in the liquid is mainly due to nitrate anions and that, due to the bidentate nature of the ligand, the complexation shell of the central ion has a nontrivial geometry and a coordination number in terms of nitrate molecules that apparently violates the decrease of ionic radii along the lanthanides series, since the smaller Lu(3+) ion seems to coordinate six nitrate molecules and the La(3+) ion only five. A closer inspection of the structural features obtained from our calculations shows, instead, that the first shell of oxygen atoms is more compact for Lu(3+) than for La(3+) and that the former coordinates 8 oxygen atoms while the latter 10 in accord with the typical lanthanide's trend along the series and that their first solvation shells have a slight irregular and complex geometrical pattern. When moving to the HOEAN solutions, we have found that the solvation of the central ion is possibly also due to the cation itself through the oxygen atom on the side chain. Also, in this liquid, the coordination numbers in terms of oxygen atoms in both solvents is 10 for La(3+) and 8 for Lu(3+).

  1. 33 CFR 187.101 - What information must be collected to identify a vessel owner?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... this section. (4) Owner identifier, which must be the owner's tax identification number, date of birth together with driver's license number, or date of birth together with other unique number. (b) A... the owner's tax identification number, date of birth together with driver's license number, or date...

  2. 33 CFR 187.101 - What information must be collected to identify a vessel owner?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... this section. (4) Owner identifier, which must be the owner's tax identification number, date of birth together with driver's license number, or date of birth together with other unique number. (b) A... the owner's tax identification number, date of birth together with driver's license number, or date...

  3. Materials Data on C3N4 (SG:187) by Materials Project

    SciTech Connect

    Kristin Persson

    2014-07-09

    Computed materials data using density functional theory calculations. These calculations determine the electronic structure of bulk materials by solving approximations to the Schrodinger equation. For more information, see https://materialsproject.org/docs/calculations

  4. Materials Data on SmNiAs (SG:187) by Materials Project

    DOE Data Explorer

    Kristin Persson

    2016-02-05

    Computed materials data using density functional theory calculations. These calculations determine the electronic structure of bulk materials by solving approximations to the Schrodinger equation. For more information, see https://materialsproject.org/docs/calculations

  5. 16 CFR 18.7 - Misrepresentation as to character of business.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ..., offering for sale, or distribution of industry products, it is an unfair or deceptive act or practice for... placement thereof, when such is not the fact, or in any other manner to misrepresent directly or...

  6. 14 CFR Appendix B to Part 187 - Fees for FAA Services for Certain Flights

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... appendix, the fee is computed based on the distance flown in either enroute or oceanic airspace (U.S.-controlled airspace.) Distance flown is based on the great circle distance (GCD) for the point of entry and...) flown in each segment and type of U.S.-controlled airspace. Separate calculations are made...

  7. Materials Data on BaLiSi (SG:187) by Materials Project

    SciTech Connect

    Kristin Persson

    2016-04-23

    Computed materials data using density functional theory calculations. These calculations determine the electronic structure of bulk materials by solving approximations to the Schrodinger equation. For more information, see https://materialsproject.org/docs/calculations

  8. Materials Data on GaTc (SG:187) by Materials Project

    SciTech Connect

    Kristin Persson

    2016-02-05

    Computed materials data using density functional theory calculations. These calculations determine the electronic structure of bulk materials by solving approximations to the Schrodinger equation. For more information, see https://materialsproject.org/docs/calculations

  9. Maternal and child mortality indicators across 187 countries of the world: converging or diverging.

    PubMed

    Goli, Srinivas; Arokiasamy, Perianayagam

    2014-01-01

    This study reassessed the progress achieved since 1990 in maternal and child mortality indicators to test whether the progress is converging or diverging across countries worldwide. The convergence process is examined using standard parametric and non-parametric econometric models of convergence. The results of absolute convergence estimates reveal that progress in maternal and child mortality indicators is diverging for the entire period of 1990-2010 [maternal mortality ratio (MMR) - β = .00033, p < .574; neonatal mortality rate (NNMR) - β = .04367, p < .000; post-neonatal mortality rate (PNMR) - β = .02677, p < .000; under-five mortality rate (U5MR) - β = .00828, p < .000)]. In the recent period, such divergence is replaced with convergence for MMR but diverged for all the child mortality indicators. The results of Kernel density estimate reveal considerable reduction in divergence of MMR for the recent period; however, the Kernel density distribution plots show more than one 'peak' which indicates the emergence of convergence clubs based on their mortality levels. For child mortality indicators, the Kernel estimates suggest that divergence is in progress across the countries worldwide but tended to converge for countries with low mortality levels. A mere progress in global averages of maternal and child mortality indicators among a global cross-section of countries does not warranty convergence unless there is a considerable reduction in variance, skewness and range of change.

  10. 40 CFR 761.187 - Reporting importers and by persons generating PCBs in excluded manufacturing processes.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... the total quantity of inadvertently generated PCBs released to the air from excluded manufacturing... Office (DCO) (7407M), Office of Pollution Prevention and Toxics (OPPT), Environmental Protection Agency, 1200 Pennsylvania Ave., NW., Washington, DC 20460-0001, ATTN: PCB Notification. (Sec. 6, Pub. L....

  11. 30 CFR 250.187 - What are MMS' incident reporting requirements?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL... incidents that may be required by other regulatory agencies. (d) You must report all spills of oil or...

  12. 30 CFR 250.187 - What are BSEE's incident reporting requirements?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF General... may be required by other regulatory agencies. (d) You must report all spills of oil or other...

  13. 30 CFR 250.187 - What are MMS' incident reporting requirements?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF General Information and... regulatory agencies. (d) You must report all spills of oil or other liquid pollutants in accordance with...

  14. 30 CFR 250.187 - What are BSEE's incident reporting requirements?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF General... may be required by other regulatory agencies. (d) You must report all spills of oil or other...

  15. 30 CFR 250.187 - What are BSEE's incident reporting requirements?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF General... may be required by other regulatory agencies. (d) You must report all spills of oil or other...

  16. Materials Data on TcB (SG:187) by Materials Project

    SciTech Connect

    Kristin Persson

    2016-07-27

    Computed materials data using density functional theory calculations. These calculations determine the electronic structure of bulk materials by solving approximations to the Schrodinger equation. For more information, see https://materialsproject.org/docs/calculations

  17. Materials Data on TcN (SG:187) by Materials Project

    SciTech Connect

    Kristin Persson

    2016-05-19

    Computed materials data using density functional theory calculations. These calculations determine the electronic structure of bulk materials by solving approximations to the Schrodinger equation. For more information, see https://materialsproject.org/docs/calculations

  18. Materials Data on OsC2 (SG:187) by Materials Project

    SciTech Connect

    Kristin Persson

    2016-09-19

    Computed materials data using density functional theory calculations. These calculations determine the electronic structure of bulk materials by solving approximations to the Schrodinger equation. For more information, see https://materialsproject.org/docs/calculations

  19. Materials Data on OsC (SG:187) by Materials Project

    SciTech Connect

    Kristin Persson

    2016-02-10

    Computed materials data using density functional theory calculations. These calculations determine the electronic structure of bulk materials by solving approximations to the Schrodinger equation. For more information, see https://materialsproject.org/docs/calculations

  20. Materials Data on RuC (SG:187) by Materials Project

    SciTech Connect

    Kristin Persson

    2015-02-09

    Computed materials data using density functional theory calculations. These calculations determine the electronic structure of bulk materials by solving approximations to the Schrodinger equation. For more information, see https://materialsproject.org/docs/calculations