... Caregiver Education » Fact Sheets Machado-Joseph Disease Fact Sheet What is Machado-Joseph disease? What are the ... the repeat is in a protein-producing or coding region of the gene. Modifications of the mutant ...
Mendonça, Liliana S; Nóbrega, Clévio; Hirai, Hirokazu; Kaspar, Brian K; Pereira de Almeida, Luís
2015-02-01
Machado-Joseph disease is a neurodegenerative disease without effective treatment. Patients with Machado-Joseph disease exhibit significant motor impairments such as gait ataxia, associated with multiple neuropathological changes including mutant ATXN3 inclusions, marked neuronal loss and atrophy of the cerebellum. Thus, an effective treatment of symptomatic patients with Machado-Joseph disease may require cell replacement, which we investigated in this study. For this purpose, we injected cerebellar neural stem cells into the cerebellum of adult Machado-Joseph disease transgenic mice and assessed the effect on the neuropathology, neuroinflammation mediators and neurotrophic factor levels and motor coordination. We found that upon transplantation into the cerebellum of adult Machado-Joseph disease mice, cerebellar neural stem cells differentiate into neurons, astrocytes and oligodendrocytes. Importantly, cerebellar neural stem cell transplantation mediated a significant and robust alleviation of the motor behaviour impairments, which correlated with preservation from Machado-Joseph disease-associated neuropathology, namely reduction of Purkinje cell loss, reduction of cellular layer shrinkage and mutant ATXN3 aggregates. Additionally, a significant reduction of neuroinflammation and an increase of neurotrophic factors levels was observed, indicating that transplantation of cerebellar neural stem cells also triggers important neuroprotective effects. Thus, cerebellar neural stem cells have the potential to be used as a cell replacement and neuroprotective approach for Machado-Joseph disease therapy. © The Author (2014). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
Costa, Maria do Carmo; Ashraf, Naila S.; Fischer, Svetlana; Yang, Yemen; Schapka, Emily; Joshi, Gnanada; McQuade, Thomas J.; Dharia, Rahil M.; Dulchavsky, Mark; Ouyang, Michelle; Cook, David; Sun, Duxin; Larsen, Martha J.; Gestwicki, Jason E.; Todi, Sokol V.; Ivanova, Magdalena I.; Paulson, Henry L.
2016-01-01
No disease-modifying treatment exists for the fatal neurodegenerative polyglutamine disease known both as Machado-Joseph disease and spinocerebellar ataxia type 3. As a potential route to therapy, we identified small molecules that reduce levels of the mutant disease protein, ATXN3. Screens of a small molecule collection, including 1250 Food and Drug Administration-approved drugs, in a novel cell-based assay, followed by secondary screens in brain slice cultures from transgenic mice expressing the human disease gene, identified the atypical antipsychotic aripiprazole as one of the hits. Aripiprazole increased longevity in a Drosophila model of Machado-Joseph disease and effectively reduced aggregated ATXN3 species in flies and in brains of transgenic mice treated for 10 days. The aripiprazole-mediated decrease in ATXN3 abundance may reflect a complex response culminating in the modulation of specific components of cellular protein homeostasis. Aripiprazole represents a potentially promising therapeutic drug for Machado-Joseph disease and possibly other neurological proteinopathies. PMID:27645800
... for drunkenness, difficulty with speech and swallowing, involuntary eye movements, double vision, and frequent urination. Some individuals also ... color and/or contrast, and inability to control eye movements. × Definition Machado-Joseph disease (MJD), which is also ...
Teixeira-Castro, Andreia; Kang, Soosung; da Silva Santos, Liliana; Silva-Fernandes, Anabela; Neto, Mário F.; Brielmann, Renée M.; Bessa, Carlos; Duarte-Silva, Sara; Miranda, Adriana; Oliveira, Stéphanie; Neves-Carvalho, Andreia; Bessa, João; Summavielle, Teresa; Silverman, Richard B.; Oliveira, Pedro; Morimoto, Richard I.
2015-01-01
Polyglutamine diseases are a class of dominantly inherited neurodegenerative disorders for which there is no effective treatment. Here we provide evidence that activation of serotonergic signalling is beneficial in animal models of Machado-Joseph disease. We identified citalopram, a selective serotonin reuptake inhibitor, in a small molecule screen of FDA-approved drugs that rescued neuronal dysfunction and reduced aggregation using a Caenorhabditis elegans model of mutant ataxin 3-induced neurotoxicity. MOD-5, the C. elegans orthologue of the serotonin transporter and cellular target of citalopram, and the serotonin receptors SER-1 and SER-4 were strong genetic modifiers of ataxin 3 neurotoxicity and necessary for therapeutic efficacy. Moreover, chronic treatment of CMVMJD135 mice with citalopram significantly reduced ataxin 3 neuronal inclusions and astrogliosis, rescued diminished body weight and strikingly ameliorated motor symptoms. These results suggest that small molecule modulation of serotonergic signalling represents a promising therapeutic target for Machado-Joseph disease. PMID:26373603
Machado-Joseph disease in pedigrees of Azorean descent is linked to chromosome 14.
St George-Hyslop, P; Rogaeva, E; Huterer, J; Tsuda, T; Santos, J; Haines, J L; Schlumpf, K; Rogaev, E I; Liang, Y; McLachlan, D R
1994-07-01
A locus for Machado-Joseph disease (MJD) has recently been mapped to a 30-cM region of chromosome 14q in five pedigrees of Japanese descent. MJD is a clinically pleomorphic neurodegenerative disease that was originally described in subjects of Azorean descent. In light of the nonallelic heterogeneity in other inherited spinocerebellar ataxias, we were interested to determine if the MJD phenotype in Japanese and Azorean pedigrees arose from mutations at the same locus. We provide evidence that MJD in five pedigrees of Azorean descent is also linked to chromosome 14q in an 18-cM region between the markers D14S67 and AACT (multipoint lod score +7.00 near D14S81). We also report molecular evidence for homozygosity at the MJD locus in an MJD-affected subject with severe, early-onset symptoms. These observations confirm the initial report of linkage of MJD to chromosome 14; suggest that MJD in Japanese and Azorean subjects may represent allelic or identical mutations at the same locus; and provide one possible explanation (MJD gene dosage) for the observed phenotypic heterogeneity in this disease.
Cancel, Géraldine; Abbas, Nacer; Stevanin, Giovanni; Dürr, Alexandra; Chneiweiss, Hervé; Néri, Christian; Duyckaerts, Charles; Penet, Christiane; Cann, Howard M.; Agid, Yves; Brice, Alexis
1995-01-01
The spinocerebellar ataxia 3 locus (SCA3) for type I autosomal dominant cerebellar ataxia (ADCA type I), a clinically and genetically heterogeneous group of neuro-degenerative disorders, has been mapped to chromosome 14q32.1. ADCA type I patients from families segregating SCA3 share clinical features in common with those with Machado-Joseph disease (MJD), the gene of which maps to the same region. We show here that the disease gene segregating in each of three French ADCA type I kindreds and in a French family with neuropatho-logical findings suggesting the ataxochoreic form of dentatorubropallidoluysian atrophy carries an expanded CAG repeat sequence located at the same locus as that for MJD. Analysis of the mutation in these families shows a strong negative correlation between size of the expanded CAG repeat and age at onset of clinical disease. Instability of the expanded triplet repeat was not found to be affected by sex of the parent transmitting the mutation. Evidence was found for somatic and gonadal mosaicism for alleles carrying expanded trinucleotide repeats. ImagesFigure 3Figure 5 PMID:7573040
Machado-Joseph Disease in Pedigrees of Azorean descent is Linked to Chromosome 14
George-Hyslop, P. St; Rogaeva, E.; Huterer, J.; Tsuda, T.; Santos, J.; Haines, J. L.; Schlumpf, K.; Rogaev, E. I.; Liang, Y.; McLachlan, D. R. Crapper; Kennedy, J.; Weissenbach, J.; Billingsley, G. D.; Cox, D. W.; Lang, A. E.; Wherrett, J. R.
1994-01-01
A locus for Machado-Joseph disease (MJD) has recently been mapped to a 30-cM region of chromosome 14q in five pedigrees of Japanese descent. MJD is a clinically pleomorphic neurodegenerative disease that was originally described in subjects of Azorean descent. In light of the nonallelic heterogeneity in other inherited spinocere-bellar ataxias, we were interested to determine if the MJD phenotype in Japanese and Azorean pedigrees arose from mutations at the same locus. We provide evidence that MJD in five pedigrees of Azorean descent is also linked to chromosome 14q in an 18-cM region between the markers D14S67 and AACT (multipoint lod score +7.00 near D14S81). We also report molecular evidence for homozy-gosity at the MJD locus in an MJD-affected subject with severe, early-onset symptoms. These observations confirm the initial report of linkage of MJD to chromosome 14; suggest that MJD in Japanese and Azorean subjects may represent allelic or identical mutations at the same locus; and provide one possible explanation (MJD gene dosage) for the observed phenotypic heterogeneity in this disease. PMID:8023841
Stevanin, Giovanni; Cassa, Eloy; Cancel, Géraldine; Abbas, Nacer; Dürr, Alexandra; Jardim, Edymar; Agid, Yves; Sousa, Patricia S; Brice, Alexis
1995-01-01
Machado-Joseph disease (MJD) is an autosomal dominant neurodegenerative disorder which has been shown to result, in Japanese families, from the expansion of a CAG repeat in the MJD1 gene on chromosome 14q. We show that the same molecular mechanism is responsible for MJD in four large Brazilian kindreds of Portuguese descent. The behaviour of the mutation was evaluated in 28 affected and 19 asymptomatic gene carriers. The number of repeats in the expanded alleles ranged from 66 to 77 with a strong negative correlation with age at onset (r=0·79). A mean 1·6 repeats increase from generation to generation correlated with clinical anticipation. Instability of the CAG repeat was bidirectional, with expansions as well as contractions, and was more marked in paternal transmissions. Finally, linkage disequilibrium was complete at locus D14S280 in the four Portuguese-Brazilian kindreds and four previously reported French families with the same mutation, which suggests the existence of a common founder. PMID:8558567
Schuler-Faccini, Lavínia; Osorio, Claudio Maria; Romariz, Flavia; Paneque, Milena; Sequeiros, Jorge; Jardim, Laura Bannach
2014-01-01
Machado-Joseph disease (MJD) is an autosomal dominant, late-onset neurological disorder and the most common form of spinocerebellar ataxia (SCA) worldwide. Diagnostic genetic testing is available to detect the disease-causing mutation by direct sizing of the CAG repeat tract in the ataxin 3 gene. Presymptomatic testing (PST) can be used to identify persons at risk of developing the disease. Genetic counseling provides patients with information about the disease, genetic risks, PST, and the decision-making process. In this study, we present the protocol used in PST for MJD and the relevant observations from two centers: Brazil (Porto Alegre) and Portugal (Porto). We provide a case report that illustrates the significant ethical and psychological issues related to PST in late-onset neurological disorders. In both centers, counseling and PST are performed by a multidisciplinary team, and genetic testing is conducted at the same institutions. From 1999 to 2012, 343 individuals sought PST in Porto Alegre; 263 (77%) of these individuals were from families with MJD. In Porto, 1,530 individuals sought PST between 1996 and 2013, but only 66 (4%) individuals were from families with MJD. In Brazil, approximately 50% of the people seeking PST eventually took the test and received their results, whereas 77% took the test in Portugal. In this case report, we highlight several issues that might be raised by the consultand and how the team can extract significant information. Literature about PST testing for MJD and other SCAs is scarce, and we hope this report will encourage similar studies and enable the implementation of PST protocols in other populations, mainly in Latin America. PMID:24764760
Cancer in Machado-Joseph disease patients-low frequency as a cause of death.
Souza, Gabriele Nunes; Kersting, Nathália; Gonçalves, Thomaz Abramsson; Pacheco, Daphne Louise Oliveira; Saraiva-Pereira, Maria-Luiza; Camey, Suzi Alves; Saute, Jonas Alex Morales; Jardim, Laura Bannach
2017-04-01
Since polyglutamine diseases have been related to a reduced risk of cancer, we aimed to study the 15 years cumulative incidence of cancer (CIC) (arm 1) and the proportion of cancer as a cause of death (arm 2) in symptomatic carriers of spinocerebellar ataxia type 3/Machado-Joseph disease (SCA3/MJD). SCA3/MJD and control individuals from our state were invited to participate. A structured interview was performed. CIC as published by the Brazilian National Institute of Cancer, was used as populational control. Causes of death were obtained from the Public Information System on Mortality. We interviewed 154 SCA3/MJD patients and 80 unrelated controls: CIC was 7/154 (4.5%) and 5/80 (6.3%), respectively. The interim analysis for futility showed that the number of individuals required to detect a significant difference between groups (1938) would be three times larger than the existing local SCA3/MJD population (625), for an absolute risk reduction of 1.8%. Then this study arm was discontinued due to lack of power. In the same period, cancer was a cause of death in 9/101 (8.9%) SCA3/MJD and in 52/202 (26.2%) controls, with an absolute reduction risk of 17.3% (OR 0.27, 95%CI 0.13 to 0.58, p = 0.01). A significant reduction of cancer as cause of death was observed in SCA3/MJD, suggesting a common effect to all polyglutamine diseases. Copyright © 2017. Published by Elsevier Inc.
Twist, E C; Casaubon, L K; Ruttledge, M H; Rao, V S; Macleod, P M; Radvany, J; Zhao, Z; Rosenberg, R N; Farrer, L A; Rouleau, G A
1995-01-01
Machado Joseph disease (MJD) is an autosomal dominantly inherited neuro-degenerative disorder primarily affecting the motor system. It can be divided into three phenotypes based on the variable combination of a range of clinical symptoms including pyramidal and extra-pyramidal features, cerebellar deficits, and distal muscle atrophy. MJD is thought to be caused by mutation of a single gene which has recently been mapped, using genetic linkage analysis, to a 29 cM region on chromosome 14q24.3-q32 in five Japanese families. A second disorder, spinocerebellar ataxia type 3 (SCA3), which has clinical symptoms similar to MJD, has also been linked to the same region of chromosome 14q in two French families. In order to narrow down the region of chromosome 14 which contains the MJD locus and to determine if this region overlaps with the predisposing locus for SCA3, we have performed genetic linkage analysis in seven MJD families, six of Portuguese/Azorean origin and one of Brazilian origin, using nine microsatellite markers mapped to 14q24.3-q32. Our results localise the MJD locus in these families to an 11 cM interval flanked by the markers D14S68 and AFM343vf1. In addition we show that this 11 cM interval maps within the 15 cM interval containing the SCA3 locus, suggesting that these diseases are allelic. PMID:7897622
Conceição, Mariana; Mendonça, Liliana; Nóbrega, Clévio; Gomes, Célia; Costa, Pedro; Hirai, Hirokazu; Moreira, João Nuno; Lima, Maria C; Manjunath, N; Pereira de Almeida, Luís
2016-03-01
Others and we showed that RNA interference holds great promise for the treatment of dominantly inherited neurodegenerative disorders such as Machado-Joseph disease (MJD), for which there is no available treatment. However, successful experiments involved intracranial administration of viral vectors and there is a need for a safer and less invasive procedure. In this work, we successfully generated stable nucleic acid lipid particles (SNALPs), incorporating a short peptide derived from rabies virus glycoprotein (RVG-9r) and encapsulating small interfering RNAs (siRNAs), which can target mutant ataxin-3. The developed formulation exhibited important features that make it adequate for systemic administration: high encapsulation efficiency of siRNAs, ability to protect the encapsulated siRNAs, appropriate and homogeneous particle size distribution. Following optimization of the formulation and in vitro validation of its efficacy to silence the MJD-causing protein - mutant ataxin-3 - in neuronal cells, in vivo experiments showed that intravenous administration of RVG-9r-targeted SNALPs efficiently silenced mutant ataxin-3 reducing neuropathology and motor behavior deficits in two mouse models of MJD. To our knowledge, this is the first report showing beneficial impact of a non-viral gene silencing strategy in MJD and the first time that a non-invasive systemic administration proved to be beneficial on a polyglutamine disorder. Our study opens new avenues towards MJD therapy that can also be applied to other neurodegenerative diseases linked to the production of pathogenic proteins. Copyright © 2015 Elsevier Ltd. All rights reserved.
Nystagmus as an early ocular alteration in Machado-Joseph disease (MJD/SCA3)
2014-01-01
Background Machado-Joseph disease (MJD), also named spinocerebellar ataxia type 3 (SCA3) is the most common autosomal dominant ataxia worldwide. Although nystagmus is one of the most frequently reported ocular alterations in MJD patients its behaviour during the course of the disease, namely in its early stages, has only recently started to be investigated. The main goal of this work was to characterize the frequency of nystagmus in symptomatic and presymptomatic carriers of the MJD mutation, and investigate its usefulness as an early indicator of the disease. Methods We conducted an observational study of Azorean MJD family members, comprising a total of 158 subjects which underwent neurological evaluation. Sixty eight were clinically and molecularly diagnosed with MJD, 48 were confirmed asymptomatic carriers and 42 were confirmed non-carriers of the MJD mutation. The frequency of nystagmus was calculated for the 3 groups. Results Nystagmus was present in 88% of the MJD patients. Seventeen percent of the at-risk subjects with a carrier result in the molecular test and none of the 42 individuals who received a non-carrier test result displayed nystagmus (p < 0.006). Although not reaching statistical significance, symptomatic subjects showing nystagmus had a tendency for a higher length of the CAG tract in the expanded allele, when compared to individuals who did not have nystagmus. Conclusions The frequency of nystagmus in asymptomatic carriers and its absence in non-carriers of the mutation, suggests that nystagmus may appear before gait disturbance and can thus be considered an early sign of MJD. PMID:24450306
DOE Office of Scientific and Technical Information (OSTI.GOV)
Ranum, L.P.W.; Gomez, C.; Orr, H.T.
1995-09-01
The ataxias are a complex group of diseases with both environmental and genetic causes. Among the autosomal dominant forms of ataxia the genes for two, spinocerebellar ataxia type 1 (SCA1) and Machado-Joseph disease (MJD), have been isolated. In both of these disorders the molecular basis of disease is the expansion of an unstable CAG trinucleotide repeat. To assess the frequency of the SCA1 and MJD trinucleotide repeat expansions among individuals diagnosed with ataxia, we have collected DNA from individuals representing 311 families with adult-onset ataxia of unknown etiology and screened these samples for trinucleotide repeat expansions within the SCA1 andmore » MJD genes. Within this group there are 149 families with dominantly inherited ataxia. Of these, 3% have SCA1 trinucleotide repeat expansions, whereas 21% were positive for the MJD trinucleotide expansion. Thus, together SCA1 and MJD represent 24% of the autosomal dominant ataxias in our group, and the frequency of MJD is substantially greater than that of SCA1. For the 57 patients with MJD trinucleotide repeat expansions, a strong inverse correlation between CAG repeat size and age at onset was observed (r = -.838). Among the MJD patients, the normal and affected ranges of CAG repeat size are 14-40 and 68-82 repeats, respectively. For SCA1 the normal and affected ranges are much closer, containing 19-38 and 40-81 CAG repeats, respectively. 30 refs., 1 fig., 3 tabs.« less
Duarte-Silva, S; Silva-Fernandes, A; Neves-Carvalho, A; Soares-Cunha, C; Teixeira-Castro, A; Maciel, P
2016-01-28
A major pathological hallmark in several neurodegenerative disorders, like polyglutamine disorders (polyQ), including Machado-Joseph disease (MJD), is the formation of protein aggregates. MJD is caused by a CAG repeat expansion in the ATXN3 gene, resulting in an abnormal protein, which is prone to misfolding and forms cytoplasmic and nuclear aggregates within neurons, ultimately inducing neurodegeneration. Treatment of proteinopathies with drugs that up-regulate autophagy has shown promising results in models of polyQ diseases. Temsirolimus (CCI-779) inhibits the mammalian target of rapamycin (m-TOR), while lithium chloride (LiCl) acts by inhibiting inositol monophosphatase, both being able to induce autophagy. We have previously shown that chronic treatment with LiCl (10.4 mg/kg) had limited effects in a transgenic MJD mouse model. Also, others have shown that CCI-779 had mild positive effects in a different mouse model of the disease. It has been suggested that the combination of mTOR-dependent and -independent autophagy inducers could be a more effective therapeutic approach. To further explore this avenue toward therapy, we treated CMVMJD135 transgenic mice with a conjugation of CCI-779 and LiCl, both at concentrations known to induce autophagy and not to be toxic. Surprisingly, this combined treatment proved to be deleterious to both wild-type (wt) and transgenic animals, failing to rescue their neurological symptoms and actually exerting neurotoxic effects. These results highlight the possible dangers of manipulating autophagy in the nervous system and suggest that a better understanding of the potential disruption in the autophagy pathway in MJD is required before successful long-term autophagy modulating therapies can be developed. Copyright © 2015 IBRO. Published by Elsevier Ltd. All rights reserved.
Planning Future Clinical Trials for Machado-Joseph Disease.
Saute, Jonas Alex Morales; Jardim, Laura Bannach
2018-01-01
Spinocerebellar ataxia type 3/Machado-Joseph disease (SCA3/MJD) is an autosomal dominant multiple neurological systems degenerative disorder caused by a CAG repeat expansion at ATXN3 gene. Only a few treatments were evaluated in randomized clinical trials (RCT) in SCA3/MJD patients, with a lack of evidence for both disease-modifying and symptomatic therapies. The present chapter discuss in detail major methodological issues for planning future RCT for SCA3/MJD. There are several potential therapies for SCA3/MJD with encouraging preclinical results. Route of treatment, dosage titration and potential therapy biomarkers might differ among candidate drugs; however, the core study design and protocol will be mostly the same. RCT against placebo group is the best study design to test a disease-modifying therapy; the same cannot be stated for some symptomatic treatments. Main outcomes for future RCT are clinical scales: the Scale for the Assessment and Rating of ataxia (SARA) is currently the instrument of choice to prove efficacy of disease-modifying or symptomatic treatments against ataxia, the most important disease feature. Ataxia quantitative scales or its composite scores can be used as primary outcomes to provide preliminary evidence of efficacy in phase 2 RCT, due to a greater sensitivity to change. Details regarding eligibility criteria, randomization, sample size estimation, duration and type of analysis for both disease modifying and symptomatic treatment trials, were also discussed. Finally, a section anticipates the methodological issues for testing novel drugs when an effective treatment is already available. We conclude emphasizing four points, the first being the need of RCT for a number of different aims in the care of SCA3/MJD. Due to large sample sizes needed to warrant power, RCT for disease-modifying therapies should be multicenter enterprises. There is an urge need for surrogate markers validated for several drug classes. Finally, engagement of at risk or presymptomatic individuals in future trials will enable major advances on treatment research for SCA3/MJD.
Raposo, Mafalda; Ramos, Amanda; Santos, Cristina; Kazachkova, Nadiya; Teixeira, Balbina; Bettencourt, Conceição; Lima, Manuela
2018-04-21
Molecular alterations reflecting pathophysiologic changes thought to occur many years before the clinical onset of Machado-Joseph disease (MJD)/spinocerebellar ataxia type 3 (SCA3), a late-onset polyglutamine disorder, remain unidentified. The absence of molecular biomarkers hampers clinical trials, which lack sensitive measures of disease progression, preventing the identification of events occurring prior to clinical onset. Our aim was to analyse the mtDNA content and the amount of the common deletion (m.8482_13460del4977) in a cohort of 16 preataxic MJD mutation carriers, 85 MJD patients and 101 apparently healthy age-matched controls. Relative expression levels of RPPH1, MT-ND1 and MT-ND4 genes were assessed by quantitative real-time PCR. The mtDNA content was calculated as the difference between the expression levels of a mitochondrial gene (MT-ND1) and a nuclear gene (RPPH1); the amount of mtDNA common deletion was calculated as the difference between expression levels of a deleted (MT-ND4) and an undeleted (MT-ND1) mitochondrial genes. mtDNA content in MJD carriers was similar to that of healthy age-matched controls, whereas the percentage of the common deletion was significantly increased in MJD subjects, and more pronounced in the preclinical stage (p < 0.05). The BCL2/BAX ratio was decreased in preataxic carriers compared to controls, suggesting that the mitochondrial-mediated apoptotic pathway is altered in MJD. Our findings demonstrate for the first time that accumulation of common deletion starts in the preclinical stage. Such early alterations provide support to the current understanding that any therapeutic intervention in MJD should start before the overt clinical phenotype.
Leite, Ângela; Dinis, Maria Alzira P; Sequeiros, Jorge; Paúl, Constança
2017-02-01
This study addresses the relation between illness representations, knowledge and motivation to perform the presymptomatic testing (PST) of subjects at-risk for Familial Amyloydotic Polyneuropathy (FAP), Huntington's disease (HD) and Machado-Joseph disease (MJD), compared with subjects at-risk for Hereditary Hemochromatosis (HH). The sample comprised a clinical group of 213 subjects at genetic risk for FAP, HD and MJD, and a comparison group of 31 subjects at genetic risk for HH, that answered three open-ended questions relating illness representations, knowledge about the disease, and motivation to perform PST. People at-risk for FAP, HD and MJD use more metaphors, make more references to the family, are more concerned with the future and feel more out of curiosity and to learn, than for HH. These subjects at-risk correspond to the profile of somatic individual or personhood, wherein the unsubjectivation of the disease can function as a coping mechanism.
Gonzalez, Carlos; Gomes, Elisabete; Kazachkova, Nadiya; Bettencourt, Conceição; Raposo, Mafalda; Kay, Teresa Taylor; MacLeod, Patrick; Vasconcelos, João; Lima, Manuela
2012-12-01
The present study on long-term outcome of presymptomatic testing for Machado-Joseph disease (MJD) aimed to evaluate the psychological well-being and the familial satisfaction of subjects that 5 years prior received an unfavorable result in the predictive testing (PT). The study included 47 testees of Azorean origin (23 from the island of Flores and 24 from S. Miguel) that completed the fourth evaluation session of the MJD protocol, and undertook a neurological examination at the moment of participation in the study. Nearly 50% of testees were symptomatic at the time of the study. Psychological well-being of the 47 participants was evaluated using the Psychological General Well-Being Index (PGWB). The family satisfaction scale by adjectives was applied to obtain information on family dynamics. The average PGWB score of the total participants was of 73.3, a value indicative of psychological well-being. Nearly half of the testees presented scores indicating psychological well-being, whereas scores indicating moderate (28.9%) or severe (23.7%) stress were found in the remaining. The average score in the PGWB scale was lower in symptomatic than in asymptomatic subjects; moreover, the distinct distribution of the well-being categories seen in the two groups shows an impact of the appearance of first symptoms on the psychological state. Motives for undertaking the test, provided 5 years prior, failed to show an impact in well-being. The average score for familial satisfaction was of 134, a value compatible with high familial satisfaction, which represented the most frequent category (59.6%). Results demonstrate that well-being and family satisfaction need to be monitored in confirmed carriers of the MJD mutation. The inclusion of acceptance studies, after PT, as well as the development of acceptance training actions, should be of major importance to anticipate the possibility of psychological damage.
The neuroprotective effects of caffeine in neurodegenerative diseases.
Kolahdouzan, Mahshad; Hamadeh, Mazen J
2017-04-01
Caffeine is the most widely used psychostimulant in Western countries, with antioxidant, anti-inflammatory and anti-apoptotic properties. In Alzheimer's disease (AD), caffeine is beneficial in both men and women, in humans and animals. Similar effects of caffeine were observed in men with Parkinson's disease (PD); however, the effect of caffeine in female PD patients is controversial due to caffeine's competition with estrogen for the estrogen-metabolizing enzyme, CYP1A2. Studies conducted in animal models of amyotrophic lateral sclerosis (ALS) showed protective effects of A 2 A R antagonism. A study found caffeine to be associated with earlier age of onset of Huntington's disease (HD) at intakes >190 mg/d, but studies in animal models have found equivocal results. Caffeine is protective in AD and PD at dosages equivalent to 3-5 mg/kg. However, further research is needed to investigate the effects of caffeine on PD in women. As well, the effects of caffeine in ALS, HD and Machado-Joseph disease need to be further investigated. Caffeine's most salient mechanisms of action relevant to neurodegenerative diseases need to be further explored. © 2017 John Wiley & Sons Ltd.
Mori, Fumiaki; Tanji, Kunikazu; Odagiri, Saori; Toyoshima, Yasuko; Yoshida, Mari; Kakita, Akiyoshi; Takahashi, Hitoshi; Wakabayashi, Koichi
2012-08-01
Incorporation of ubiquitin and ubiquitin-related proteins including p62 into neuronal intranuclear inclusions (NIIs) has been reported in a variety of neurodegenerative diseases. However, involvement of autophagy-specific proteins (NBR1 and LC3) in NIIs has not been mentioned. We immunohistochemically examined the brain of patients with Machado-Joseph disease (MJD; n=5), dentatorubral-pallidoluysian atrophy (DRPLA; n=5) and intranuclear inclusion body disease (INIBD; n=5), using antibodies against ubiquitin, p62, NBR1 and LC3. The proportion of p62-, NBR1- and LC3-positive inclusions relative to the number of ubiquitin-positive inclusions was calculated in each case. NIIs were positive for p62 in MJD (19.3%), DRPLA (49.7%) and INIBD (99.8%). As for autophagy-specific proteins, NIIs were positive for NBR1 in MJD (4.2%), DRPLA (5.5%) and INIBD (13.2%) and negative for LC3 in MJD, DRPLA and INIBD, except for one case of INIBD. These findings suggest that autophagy-lysosome pathway is not involved in the formation/degradation of NIIs. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
Novel polyglutamine model uncouples proteotoxicity from aging.
Christie, Nakeirah T M; Lee, Amy L; Fay, Hannah G; Gray, Amelia A; Kikis, Elise A
2014-01-01
Polyglutamine expansions in certain proteins are the genetic determinants for nine distinct progressive neurodegenerative disorders and resultant age-related dementia. In these cases, neurodegeneration is due to the aggregation propensity and resultant toxic properties of the polyglutamine-containing proteins. We are interested in elucidating the underlying mechanisms of toxicity of the protein ataxin-3, in which a polyglutamine expansion is the genetic determinant for Machado-Joseph Disease (MJD), also referred to as spinocerebellar ataxia 3 (SCA3). To this end, we have developed a novel model for ataxin-3 protein aggregation, by expressing a disease-related polyglutamine-containing fragment of ataxin-3 in the genetically tractable body wall muscle cells of the model system C. elegans. Here, we demonstrate that this ataxin-3 fragment aggregates in a polyQ length-dependent manner in C. elegans muscle cells and that this aggregation is associated with cellular dysfunction. However, surprisingly, this aggregation and resultant toxicity was not influenced by aging. This is in contrast to polyglutamine peptides alone whose aggregation/toxicity is highly dependent on age. Thus, the data presented here not only describe a new polyglutamine model, but also suggest that protein context likely influences the cellular interactions of the polyglutamine-containing protein and thereby modulates its toxic properties.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Ito, Norie; Department of Neurology, Sapporo Medical University School of Medicine, South-1, West-17, Chuo-ku, Sapporo 060-8556; Kamiguchi, Kenjiro
Polyglutamine (polyQ) diseases comprise neurodegenerative disorders caused by expression of expanded polyQ-containing proteins. The cytotoxicity of the expanded polyQ-containing proteins is closely associated with aggregate formation. In this study, we report that a novel J-protein, DNAJ (HSP40) Homolog, Subfamily C, Member 8 (DNAJC8), suppresses the aggregation of polyQ-containing protein in a cellular model of spinocerebellar ataxia type 3 (SCA3), which is also known as Machado-Joseph disease. Overexpression of DNAJC8 in SH-SY5Y neuroblastoma cells significantly reduced the polyQ aggregation and apoptosis, and DNAJC8 was co-localized with the polyQ aggregation in the cell nucleus. Deletion mutants of DNAJC8 revealed that the C-terminalmore » domain of DNAJC8 was essential for the suppression of polyQ aggregation, whereas the J-domain was dispensable. Furthermore, 22-mer oligopeptide derived from C-termilal domain could suppress the polyQ aggregation. These results indicate that DNAJC8 can suppress the polyQ aggregation via a distinct mechanism independent of HSP70-based chaperone machinery and have a unique protective role against the aggregation of expanded polyQ-containing proteins such as pathogenic ataxin-3 proteins.« less
Holmberg, M; Johansson, J; Forsgren, L; Heijbel, J; Sandgren, O; Holmgren, G
1995-08-01
We present linkage analysis on a large Swedish five-generation family of 15 affected individuals with autosomal dominant cerebellar ataxia (ADCA) associated with retinal degeneration and anticipation. Common clinical signs in this family include ataxia, dysarthria and severely impaired vision with the phenotype ADCA type II. Different subtypes of ADCA have proven difficult to classify clinically due to extensive phenotypic variability within and between families. Genetic analysis of a number of ADCA type I families shows that heterogeneity exists also genetically. During the last few years several types of ADCA type I have been localized and to date six genetically distinct forms have been identified including SCA1 (6p), SCA2 (12q), SCA3 and Machado-Joseph disease (MJD) (14q), SCA4 (16q), and finally SCA5 (11). We performed a genome-wide search of the Swedish ADCA type II family using a total of 270 microsatellite markers. Positive lod scores were obtained with a number of microsatellite markers located on chromosome 3p12-p21.1. Three markers gave lod scores over 3 with a maximum lod score of 4.53 achieved with the marker D3S1600. The ADCA type II gene could be restricted to a region of 32 cM by the markers D3S1547 and D3S1274.
Stevanin, Giovanni; Le Guern, Eric; Ravisé, Nicole; Chneiweiss, Hervé; Dürr, Alexandra; Cancel, Géraldine; Vignal, Alain; Boch, Anne-Laure; Ruberg, Merle; Penet, Christiane; Pothin, Yolaine; Lagroua, Isabelle; Haguenau, Michel; Rancurel, Gérald; Weissenbach, Jean; Agid, Yves; Brice, Alexis
1994-01-01
The autosomal dominant cerebellar ataxias (ADCA) type I are a group of neurological disorders that are clinically and genetically heterogeneous. Two genes implicated in the disease, SCA1 (spinal cerebellar ataxia 1) and SCA2, are already localized. We have mapped a third locus to chromosome 14q24.3-qter, by linkage analysis in a non-SCA1/non-SCA2 family and have confirmed its existence in a second such family. We suggest designating this new locus “SCA3.” Combined analysis of the two families restricted the SCA3 locus to a 15-cM interval between markers D14S67 and D14S81. The gene for Machado-Joseph disease (MJD), a clinically different form of ADCA type I, has been recently assigned to chromosome 14q24.3-q32. Although the SCA3 locus is within the MJD region, linkage analyses cannot yet demonstrate whether they result from mutations of the same gene. Linkage to all three loci (SCA1, SCA2, and SCA3) was excluded in another family, which indicates the existence of a fourth ADCA type I locus. PMID:8279460
Overexpression of mutant ataxin-3 in mouse cerebellum induces ataxia and cerebellar neuropathology.
Nóbrega, Clévio; Nascimento-Ferreira, Isabel; Onofre, Isabel; Albuquerque, David; Conceição, Mariana; Déglon, Nicole; de Almeida, Luís Pereira
2013-08-01
Machado-Joseph disease (MJD), also known as spinocerebellar ataxia type 3 (SCA3), is a fatal, dominant neurodegenerative disorder caused by the polyglutamine-expanded protein ataxin-3. Clinical manifestations include cerebellar ataxia and pyramidal signs culminating in severe neuronal degeneration. Currently, there is no therapy able to modify disease progression. In the present study, we aimed at investigating one of the most severely affected brain regions in the disorder--the cerebellum--and the behavioral defects associated with the neuropathology in this region. For this purpose, we injected lentiviral vectors encoding full-length human mutant ataxin-3 in the mouse cerebellum of 3-week-old C57/BL6 mice. We show that circumscribed expression of human mutant ataxin-3 in the cerebellum mediates within a short time frame--6 weeks, the development of a behavioral phenotype including reduced motor coordination, wide-based ataxic gait, and hyperactivity. Furthermore, the expression of mutant ataxin-3 resulted in the accumulation of intranuclear inclusions, neuropathological abnormalities, and neuronal death. These data show that lentiviral-based expression of mutant ataxin-3 in the mouse cerebellum induces localized neuropathology, which is sufficient to generate a behavioral ataxic phenotype. Moreover, this approach provides a physiologically relevant, cost-effective and time-effective animal model to gain further insights into the pathogenesis of MJD and for the evaluation of experimental therapeutics of MJD.
Nakada, Tsutomu; Matsuzawa, Hitoshi; Fujii, Yukihiko; Takahashi, Hitoshi; Nishizawa, Masatoyo; Kwee, Ingrid L
2006-07-01
Clinical magnetic resonance imaging (MRI) has recently entered the "high-field" era, and systems equipped with 3.0-4.0T superconductive magnets are becoming the gold standard for diagnostic imaging. While higher signal-to-noise ratio (S/N) is a definite advantage of higher field systems, higher susceptibility effect remains to be a significant trade-off. To take advantage of a higher field system in performing routine clinical images of higher anatomical resolution, we implemented a vector contrast image technique to 3.0T imaging, three-dimensional anisotropy contrast (3DAC), with a PROPELLER (Periodically Rotated Overlapping Parallel Lines with Enhanced Reconstruction) sequence, a method capable of effectively eliminating undesired artifacts on rapid diffusion imaging sequences. One hundred subjects (20 normal volunteers and 80 volunteers with various central nervous system diseases) participated in the study. Anisotropic diffusion-weighted PROPELLER images were obtained on a General Electric (Waukesha, WI, USA) Signa 3.0T for each axis, with b-value of 1100 sec/mm(2). Subsequently, 3DAC images were constructed using in-house software written on MATLAB (MathWorks, Natick, MA, USA). The vector contrast allows for providing exquisite anatomical detail illustrated by clear identification of all major tracts through the entire brain. 3DAC images provide better anatomical resolution for brainstem glioma than higher-resolution T2 reversed images. Degenerative processes of disease-specific tracts were clearly identified as illustrated in cases of multiple system atrophy and Joseph-Machado disease. Anatomical images of significantly higher resolution than the best current standard, T2 reversed images, were successfully obtained. As a technique readily applicable under routine clinical setting, 3DAC PROPELLER on a 3.0T system will be a powerful addition to diagnostic imaging.
Takano, H; Cancel, G; Ikeuchi, T; Lorenzetti, D; Mawad, R; Stevanin, G; Didierjean, O; Dürr, A; Oyake, M; Shimohata, T; Sasaki, R; Koide, R; Igarashi, S; Hayashi, S; Takiyama, Y; Nishizawa, M; Tanaka, H; Zoghbi, H; Brice, A; Tsuji, S
1998-01-01
To test the hypothesis that the frequencies of normal alleles (ANs) with a relatively large number of CAG repeats (large ANs) are related to the prevalences of the dominant spinocerebellar ataxias (SCAs)-SCA types 1, 2, 3 (Machado-Joseph disease), 6, and dentatorubral-pallidoluysian atrophy (DRPLA)-we investigated the relative prevalences of these diseases in 202 Japanese and 177 Caucasian families and distributions of the number of CAG repeats of ANs at these disease loci in normal individuals in each population. The relative prevalences of SCA1 and SCA2 were significantly higher in Caucasian pedigrees (15% and 14%, respectively) than in Japanese pedigrees (3% and 5%, respectively), corresponding to the observation that the frequencies of large ANs of SCA1 (alleles >30 repeats) and of SCA2 (alleles >22 repeats) were significantly higher in Caucasians than in Japanese. The relative prevalences of MJD/SCA3, SCA6, and DRPLA were significantly higher in Japanese pedigrees (43%, 11%, and 20%, respectively) than in Caucasian pedigrees (30%, 5%, and 0%, respectively), corresponding to the observation that the frequencies of large ANs of MJD/SCA3 (>27 repeats), SCA6 (>13 repeats), and DRPLA (>17 repeats) were significantly higher in Japanese than in Caucasians. The close correlations of the relative prevalences of the dominant SCAs with the distributions of large ANs strongly support the assumption that large ANs contribute to generation of expanded alleles (AEs) and the relative prevalences of the dominant SCAs. PMID:9758625
Valosin-Containing Protein (VCP/p97) Is an Activator of Wild-Type Ataxin-3
Laço, Mário N.; Cortes, Luisa; Travis, Sue M.; Paulson, Henry L.; Rego, A. Cristina
2012-01-01
Alterations in the ubiquitin-proteasome system (UPS) have been reported in several neurodegenerative disorders characterized by protein misfolding and aggregation, including the polylgutamine diseases. Machado-Joseph disease (MJD) or Spinocerebellar Ataxia type 3 is caused by a polyglutamine-encoding CAG expansion in the ATXN3 gene, which encodes a 42 kDa deubiquitinating enzyme (DUB), ataxin-3. We investigated ataxin-3 deubiquitinating activity and the functional relevance of ataxin-3 interactions with two proteins previously described to interact with ataxin-3, hHR23A and valosin-containing protein (VCP/p97). We confirmed ataxin-3 affinity for both hHR23A and VCP/p97. hHR23A and ataxin-3 were shown to co-localize in discrete nuclear foci, while VCP/p97 was primarily cytoplasmic. hHR23A and VCP/p97 recombinant proteins were added, separately or together, to normal and expanded ataxin-3 in in vitro deubiquitination assays to evaluate their influence on ataxin-3 activity. VCP/p97 was shown to be an activator specifically of wild-type ataxin-3, exhibiting no effect on expanded ataxin-3, In contrast, we observed no significant alterations in ataxin-3 enzyme kinetics or substrate preference in the presence of hHR23A alone or in combination with VCP. Based on our results we propose a model where ataxin-3 normally functions with its interactors to specify the cellular fate of ubiquitinated proteins. PMID:22970133
Genetic map of the spinocerebellar ataxia type 2 (SCA2) region on chromosome 12
DOE Office of Scientific and Technical Information (OSTI.GOV)
Nechiporuk, A.; Frederick, T.; Pulst, S.M.
1994-09-01
The autosomal dominant ataxias (SCAs) are a clinically and genetically heterogeneous group of neurodegenerative diseases characterized by progressive ataxia. At least four gene loci have been identified: SCA1 on chromosome (CHR) 6, SCA2 on CHR12, Machado-Joseph disease on CHR14, and SCA families that are not linked to any of the above loci. In addition, the gene causing dentato-rubro-pallido-luysian atrophy has been identified as an expanded CAG repeat on CHR 12p. As a necessary step in identifying the gene for SCA2, we now identified closer flanking markers. To do this we ordered microsatellite markers in the now identified closer flanking markers.more » To do this we ordered microsatellite markers in the region and then determined pairwise and multipoint lod scores between the markers and SCA2 in three large pedigrees with SCA. The following order was established with odds > 1,000:1 using six non-SCA pedigrees: D12S101-7.1cM-D12S58-0cM-IGF1-3.6cM-D12S78-1.4cM-D12S317-3.7cM-D12S84-0cM-D12S105-7.2cM-D12S79-7.0cM-PLA2. Using this ordered set of markers we examined linkage to SCA2 in three pedigrees of Italian, Austrian and French-Canadian descent. Pairwise linkage analysis resulted in significant positive lod scores for all markers. The highest pairwise lod score was obtained with D12S84/D12S105 (Z{sub max}=7.98, theta{sub max}=0.05). To further define the location of SCA2, we performed multipoint linkage analysis using the genetic map established above. The highest location score was obtained between D12S317 and D12S84/D12S105. A location of SCA2 between these loci was favored with odds > 100:1. These data likely narrow the SCA2 candidate region to approximately 3.7 cM. The relatively large large number of markers tightly linked to SCA2 will facilitate the assignment of additional SCA pedigrees to CHR12, and will help in the presymptomatic diagnosis of individuals in families with proven linkage to CHR12.« less
Stevanin, G; Cancel, G; Dürr, A; Chneiweiss, H; Dubourg, O; Weissenbach, J; Cann, H M; Agid, Y; Brice, A
1995-01-01
SCA3, the gene for spinal cerebellar ataxia 3, was recently mapped to a 15-cM interval between D14S67 and D14S81 on chromosome 14q, by linkage analysis in two families of French ancestry. The SCA3 candidate region has now been refined by linkage analysis with four new microsatellite markers (D14S256, D14S291, D14S280, and AFM343vf1) in the same two families, in which 19 additional individuals were genotyped, and in a third French family. Combined two-point linkage analyses show that the new markers, D14S280 and AFM343vf1, are tightly linked to the SCA3 locus, with maximal lod scores, at recombination fraction, (theta) = .00, of 7.05 and 13.70, respectively. Combined multipoint and recombinant haplotype analyses localize the SCA3 locus to a 3-cM interval flanked by D14S291 and D14S81. The same allele for D14S280 segregates with the disease locus in the three kindreds. This allele is frequent in the French population, however, and linkage disequilibrium is not clearly established. The SCA3 locus remains within the 29-cM region on 14q24.3-q32.2 containing the gene for the Machado-Joseph disease, which is clinically related to the phenotype determined by SCA3, but it cannot yet be concluded that both diseases result from alterations of the same gene. PMID:7825578
Duarte, João Valente; Faustino, Ricardo; Lobo, Mercês; Cunha, Gil; Nunes, César; Ferreira, Carlos; Januário, Cristina; Castelo-Branco, Miguel
2016-10-01
Machado-Joseph Disease, inherited type 3 spinocerebellar ataxia (SCA3), is the most common form worldwide. Neuroimaging and neuropathology have consistently demonstrated cerebellar alterations. Here we aimed to discover whole-brain functional biomarkers, based on parametric performance-level-dependent signals. We assessed 13 patients with early SCA3 and 14 healthy participants. We used a combined parametric behavioral/functional neuroimaging design to investigate disease fingerprints, as a function of performance levels, coupled with structural MRI and voxel-based morphometry. Functional magnetic resonance imaging (fMRI) was designed to parametrically analyze behavior and neural responses to audio-paced bilateral thumb movements at temporal frequencies of 1, 3, and 5 Hz. Our performance-level-based design probing neuronal correlates of motor coordination enabled the discovery that neural activation and behavior show critical loss of parametric modulation specifically in SCA3, associated with frequency-dependent cortico/subcortical activation/deactivation patterns. Cerebellar/cortical rate-dependent dissociation patterns could clearly differentiate between groups irrespective of grey matter loss. Our findings suggest functional reorganization of the motor network and indicate a possible role of fMRI as a tool to monitor disease progression in SCA3. Accordingly, fMRI patterns proved to be potential biomarkers in early SCA3, as tested by receiver operating characteristic analysis of both behavior and neural activation at different frequencies. Discrimination analysis based on BOLD signal in response to the applied parametric finger-tapping task significantly often reached >80% sensitivity and specificity in single regions-of-interest.Functional fingerprints based on cerebellar and cortical BOLD performance dependent signal modulation can thus be combined as diagnostic and/or therapeutic targets in hereditary ataxia. Hum Brain Mapp 37:3656-3668, 2016. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.
Pharmacological treatments of cerebellar ataxia.
Ogawa, Masafumi
2004-01-01
The confirmed pharmacological treatment of cerebellar ataxia is still lacking. In a recent preliminary trial, we showed that D-cycloserine, a partial NMDA allosteric agonist, may relieve the symptoms. In this paper, major clinical trials to relieve ataxic symptoms are reviewed. Previous studies showed some efficacy of physostigmine in ataxic patients. However, physostigmine did not improve the ataxia in a recent double-blind crossover study. The replacement therapy of the deficient cholinergic system with choline or choline derivatives was tried in patients with Friedreich's ataxia and other ataxic patients, but the result was not definitive. A levorotatory form of hydroxytryptophan (a serotonin precursor), a serotoninergic 5-HT1A agonist, a serotoninergic 5-HT3 antagonist, and a serotonin reuptake inhibitor were also used for the therapy for ataxia. In a double-blind randomized study, buspirone, a 5-HT1A agonist was active in cerebellar ataxia, but the effect is partial and not major. The effects of the studies with the other serotoninergic drugs were not consistent. The effect of sulfamethoxazole-trimethoprim therapy in spinocerebellar ataxia type3/Machado-Joseph disease (MJD) was reported, although the therapy improved spasticity or rigidity, rather than ataxia. In contrast to previous studies, sulfamethoxazole-trimethoprim therapy in MJD had no effect in a 2001 double-blind crossover study. The thyrotropin-releasing hormone, D-cycloserine, and acetazolamide for SCA6 may have some efficacy. However, a well-designed double-blind crossover trial is needed to confirm the effect.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Ranum, L.P.W.; Lundgren, J.K.; Schut, L.J.
1994-09-01
Four different genes that cause spinocerebellar ataxia (SCA1, SCA2, Machado Joseph`s Disease (MJD)/SCA3 and SCA4) have been mapped to chromosomes 6p, 12q, 14q, and 16q, respectively. We have examined and collected 170 individuals (56 affected) from a previously unreported 10 generation kindred (the Lincoln Family) with a dominant ataxia that is clinically and genetically distinct from those previously mapped. The family has two major branches from Indiana and Kentucky. Of historical interest is that both branches descend from the paternal grandparents of President Abraham Lincoln. While the ataxia in this kindred is disabling, the most striking clinical distinction from SCA1,more » SCA2 and MJD/SCA3 is that it is generally not life threatening. This clinical difference is explained by the absence of bulbar paralysis and lower motor neuron degeneration that causes respiratory muscle weakness. We have mapped the gene, SCA5, using microsatellite markers spaced at 20-40 cM intervals throughout the genome. After 75 markers, the first to demonstrate a lod score greater than 3.0 was D11S871 (Zmax=5.05). Four additional markers from the centromeric region of chromosome 11 also gave lod scores greater than 3. The highest lod scores were 12.3 for both D11S905 ({theta}=0.056) and D11S913 ({theta}=0.030). Multipoint linkage and haplotype analyses indicate the most likely location for SCA5 is within the 7 cM interval between GATA2A01 and D11S913. A statistical analysis of the age of onset of parent-offspring pairs within the family supports (p<0.0002) the presence of anticipation. Several dramatic examples of anticipation have been observed in which grandmothers have onsets 10-20 years later in life than their daughters who have onsets 10-20 years later than their children. Interestingly, all four of the juvenile onset cases are maternally inherited, suggesting a maternal bias in anticipation for SCA5 rather than a paternal bias as seen with SCA1.« less
Gonçalves, Nélio; Simões, Ana T; Prediger, Rui D; Hirai, Hirokazu; Cunha, Rodrigo A; Pereira de Almeida, Luís
2017-03-01
Machado-Joseph disease (MJD) is a neurodegenerative spinocerebellar ataxia (SCA) associated with an expanded polyglutamine tract within ataxin-3 for which there is currently no available therapy. We previously showed that caffeine, a nonselective adenosine receptor antagonist, delays the appearance of striatal damage resulting from expression of full-length mutant ataxin-3. Here we investigated the ability of caffeine to alleviate behavioral deficits and cerebellar neuropathology in transgenic mice with a severe ataxia resulting from expression of a truncated fragment of polyglutamine-expanded ataxin-3 in Purkinje cells. Control and transgenic c57Bl6 mice expressing in the mouse cerebella a truncated form of human ataxin-3 with 69 glutamine repeats were allowed to freely drink water or caffeinated water (1g/L). Treatments began at 7 weeks of age, when motor and ataxic phenotype emerges in MJD mice, and lasted up to 20 weeks. Mice were tested in a panel of locomotor behavioral paradigms, namely rotarod, beam balance and walking, pole, and water maze cued-platform version tests, and then sacrificed for cerebellar histology. Caffeine consumption attenuated the progressive loss of general and fine-tuned motor function, balance, and grip strength, in parallel with preservation of cerebellar morphology through decreasing the loss of Purkinje neurons and the thinning of the molecular layer in different folia. Caffeine also rescued the putative striatal-dependent executive and cognitive deficiencies in MJD mice. Our findings provide the first in vivo demonstration that caffeine intake alleviates behavioral disabilities in a severely impaired animal model of SCA. Ann Neurol 2017;81:407-418. © 2016 American Neurological Association.
Takei, Asako; Hamada, Shinsuke; Homma, Sanae; Hamada, Keiko; Tashiro, Kunio; Hamada, Takeshi
2010-12-01
The aim of this study was to investigate the effects of tandospirone on ataxia in various types of spinocerebellar degeneration (SCD). Fifteen milligram per day of tandospirone was administered to 39 patients with SCD (spinocerebellar atrophy (SCA) 1, five patients; SCA2, six patients; Machado-Joseph disease (MJD), 14 patient; SCA6, five patients; multiple system atrophy-cerebellar type (MSA-C), seven patients; and multiple system atrophy-Parkinson type (MSA-P), two patients). All patients were assessed before and 4 weeks after administration of the drug using the international cooperative ataxia rating scale total score (ARS), total length traveled (TLT) of body stabilometry, and a self-rating depression scale. Statistically, ARS showed a significant difference in MJD (p = 0.005) and SCA6 (p = 0.043). TLT also showed a significant difference in MJD (p = 0.002) and SCA6 (p = 0.043). Eight of 39 patients (SCA1, 1/5; SCA2, 0/6; MJD, 4/14; SCA6, 3/5; MSA-C, 0/7; and MSA-P, 0/2) showed more than a five point reduction in ARS, and 13 of 39 patients (SCA1, 0/5; SCA2, 1/6; MJD, 8/14; SCA6, 4/5; MSA-C, 0/7; and MSA-P, 0/2) showed a reduction of TLT. Our data indicate that the effects of tandospirone on ataxia are different between types of SCD. Therefore, tandospirone is useful for cerebellar ataxia in patients with MJD and SCA6.
Gan, Shi-Rui; Ni, Wang; Dong, Yi; Wang, Ning; Wu, Zhi-Ying
2015-01-01
Spinocerebellar ataxia type 3 (SCA3), also called Machado-Joseph disease (MJD), is one of the most common SCAs worldwide and caused by a CAG repeat expansion located in ATXN3 gene. Based on the CAG repeat numbers, alleles of ATXN3 can be divided into normal alleles (ANs), intermediate alleles (AIs) and expanded alleles (AEs). It was controversial whether the frequency of large normal alleles (large ANs) is related to the prevalence of SCA3 or not. And there were huge chaos in the comprehension of the specific numbers of the range of CAG repeats which is fundamental for genetic analysis of SCA3. To illustrate these issues, we made a novel CAG repeat ladder to detect CAG repeats of ATXN3 in 1003 unrelated Chinese normal individuals and studied haplotypes defined by three single nucleotide polymorphisms (SNPs) closed to ATXN3. We found that the number of CAG repeats ranged from 13 to 49, among them, 14 was the most common number. Positive skew, the highest frequency of large ANs and 4 AIs which had never been reported before were found. Also, AEs and large ANs shared the same haplotypes defined by the SNPs. Based on these data and other related studies, we presumed that de novo mutations of ATXN3 emerging from large ANs are at least one survival mechanisms of mutational ATXN3 and we can redefine the range of CAG repeats as: ANs≤44, 45 ≤AIs ≤49 and AEs≥50.
The third law of thermodynamics and the fractional entropies
NASA Astrophysics Data System (ADS)
Baris Bagci, G.
2016-08-01
We consider the fractal calculus based Ubriaco and Machado entropies and investigate whether they conform to the third law of thermodynamics. The Ubriaco entropy satisfies the third law of thermodynamics in the interval 0 < q ≤ 1 exactly where it is also thermodynamically stable. The Machado entropy, on the other hand, yields diverging inverse temperature in the region 0 < q ≤ 1, albeit with non-vanishing negative entropy values. Therefore, despite the divergent inverse temperature behavior, the Machado entropy fails the third law of thermodynamics. We also show that the aforementioned results are also supported by the one-dimensional Ising model with no external field.
Juan Rulfo and Machado de Assis: Toward an Integrated New Narrative
ERIC Educational Resources Information Center
Wiseman, David P.; Krause, James R.
2016-01-01
Despite apparent connections between Brazilian and Spanish American narratives, comparative scholarship has only recently begun to investigate actively these important points of contact. In this study, we introduce a vital crossover between the two traditions, involving Juan Rulfo and Joaquim Maria Machado de Assis. Rulfo's outspoken affinity for…
Reflective Mindreading: Theory of Mind and the Search for Self in Antonio Machado's "Soledades"
ERIC Educational Resources Information Center
Mills, Steven
2011-01-01
In Antonio Machado's collection "Soledades", the poet's search for identity guides an introspective quest where context, body, and mind form an intricate and inseparable connection. By extending cognitive capabilities to his natural environment, the poet, through embodied cognition and Theory of Mind, reads other people's and nature's minds to…
The Great War and Remembrance in Jose Leon Machado's "Memoria das Estrelas sem Brilho"
ERIC Educational Resources Information Center
Azevedo, Milton M.
2011-01-01
This article analyzes Jose Leon Machado's novel, "Memoria das Estrelas sem Brilho," as a multilayered historical novel in which a war story provides a background for comments on aspects of early twentieth-century Portuguese society, such as male bonding, religion, sexual mores, and social stratification. (Contains 11 notes.)
What Is the Difference Between Hyperglycemia and Hypoglycemia?
... eye disease (retinopathy) Joseph Monks: Writer, Producer, and Film Director Joseph Monks , who has diabetic retinopathy , creates and produces films for his production company Sight Unseen Pictures. He ...
Machado de Assis's "Dom Casmurro" and "Soneto De Natal": The Calculated Mediocrity of a Mute Prophet
ERIC Educational Resources Information Center
Lewis, Christopher T.
2016-01-01
Joaquim Maria Machado de Assis's poem "Soneto de Natal" and the chapter "Um soneto" from his novel "Dom Casmurro" exhibit striking points of intersection that describe the same process: the creation of a sonnet. In the novel, Bentinho abandons his attempt with only a first and last line. "Soneto de Natal"…
Emery, A E
1989-02-01
Joseph Adams was eclectic in his interests and wrote on a variety of medical subjects. His last book published in 1814 was on hereditary disease and based on a lifetime's careful clinical observations. In it he distinguished between what would now be defined as dominant and recessive disorders; defined the term congenital; emphasised the role of inbreeding in producing clustering of certain inherited disorders; introduced concepts now known as founder effect, incomplete penetrance, and variable age at onset; emphasised the importance of environmental factors in precipitating disease in certain genetic disorders; and, finally, recommended the establishment of registers for the purpose of preventing genetic disease. But because he proposed no scientific explanation for these various ideas, they were largely ignored by his contemporaries. Nevertheless, it would seem right to regard Joseph Adams as perhaps the first clinical geneticist.
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
2017-09-28
Rare Disorders; Undiagnosed Disorders; Disorders of Unknown Prevalence; Cornelia De Lange Syndrome; Prenatal Benign Hypophosphatasia; Perinatal Lethal Hypophosphatasia; Odontohypophosphatasia; Adult Hypophosphatasia; Childhood-onset Hypophosphatasia; Infantile Hypophosphatasia; Hypophosphatasia; Kabuki Syndrome; Bohring-Opitz Syndrome; Narcolepsy Without Cataplexy; Narcolepsy-cataplexy; Hypersomnolence Disorder; Idiopathic Hypersomnia Without Long Sleep Time; Idiopathic Hypersomnia With Long Sleep Time; Idiopathic Hypersomnia; Kleine-Levin Syndrome; Kawasaki Disease; Leiomyosarcoma; Leiomyosarcoma of the Corpus Uteri; Leiomyosarcoma of the Cervix Uteri; Leiomyosarcoma of Small Intestine; Acquired Myasthenia Gravis; Addison Disease; Hyperacusis (Hyperacousis); Juvenile Myasthenia Gravis; Transient Neonatal Myasthenia Gravis; Williams Syndrome; Lyme Disease; Myasthenia Gravis; Marinesco Sjogren Syndrome(Marinesco-Sjogren Syndrome); Isolated Klippel-Feil Syndrome; Frasier Syndrome; Denys-Drash Syndrome; Beckwith-Wiedemann Syndrome; Emanuel Syndrome; Isolated Aniridia; Beckwith-Wiedemann Syndrome Due to Paternal Uniparental Disomy of Chromosome 11; Beckwith-Wiedemann Syndrome Due to Imprinting Defect of 11p15; Beckwith-Wiedemann Syndrome Due to 11p15 Translocation/Inversion; Beckwith-Wiedemann Syndrome Due to 11p15 Microduplication; Beckwith-Wiedemann Syndrome Due to 11p15 Microdeletion; Axenfeld-Rieger Syndrome; Aniridia-intellectual Disability Syndrome; Aniridia - Renal Agenesis - Psychomotor Retardation; Aniridia - Ptosis - Intellectual Disability - Familial Obesity; Aniridia - Cerebellar Ataxia - Intellectual Disability; Aniridia - Absent Patella; Aniridia; Peters Anomaly - Cataract; Peters Anomaly; Potocki-Shaffer Syndrome; Silver-Russell Syndrome Due to Maternal Uniparental Disomy of Chromosome 11; Silver-Russell Syndrome Due to Imprinting Defect of 11p15; Silver-Russell Syndrome Due to 11p15 Microduplication; Syndromic Aniridia; WAGR Syndrome; Wolf-Hirschhorn Syndrome; 4p16.3 Microduplication Syndrome; 4p Deletion Syndrome, Non-Wolf-Hirschhorn Syndrome; Autosomal Recessive Stickler Syndrome; Stickler Syndrome Type 2; Stickler Syndrome Type 1; Stickler Syndrome; Mucolipidosis Type 4; X-linked Spinocerebellar Ataxia Type 4; X-linked Spinocerebellar Ataxia Type 3; X-linked Intellectual Disability - Ataxia - Apraxia; X-linked Progressive Cerebellar Ataxia; X-linked Non Progressive Cerebellar Ataxia; X-linked Cerebellar Ataxia; Vitamin B12 Deficiency Ataxia; Toxic Exposure Ataxia; Unclassified Autosomal Dominant Spinocerebellar Ataxia; Thyroid Antibody Ataxia; Sporadic Adult-onset Ataxia of Unknown Etiology; Spinocerebellar Ataxia With Oculomotor Anomaly; Spinocerebellar Ataxia With Epilepsy; Spinocerebellar Ataxia With Axonal Neuropathy Type 2; Spinocerebellar Ataxia Type 8; Spinocerebellar Ataxia Type 7; Spinocerebellar Ataxia Type 6; Spinocerebellar Ataxia Type 5; Spinocerebellar Ataxia Type 4; Spinocerebellar Ataxia Type 37; Spinocerebellar Ataxia Type 36; Spinocerebellar Ataxia Type 35; Spinocerebellar Ataxia Type 34; Spinocerebellar Ataxia Type 32; Spinocerebellar Ataxia Type 31; Spinocerebellar Ataxia Type 30; Spinocerebellar Ataxia Type 3; Spinocerebellar Ataxia Type 29; Spinocerebellar Ataxia Type 28; Spinocerebellar Ataxia Type 27; Spinocerebellar Ataxia Type 26; Spinocerebellar Ataxia Type 25; Spinocerebellar Ataxia Type 23; Spinocerebellar Ataxia Type 22; Spinocerebellar Ataxia Type 21; Spinocerebellar Ataxia Type 20; Spinocerebellar Ataxia Type 2; Spinocerebellar Ataxia Type 19/22; Spinocerebellar Ataxia Type 18; Spinocerebellar Ataxia Type 17; Spinocerebellar Ataxia Type 16; Spinocerebellar Ataxia Type 15/16; Spinocerebellar Ataxia Type 14; Spinocerebellar Ataxia Type 13; Spinocerebellar Ataxia Type 12; Spinocerebellar Ataxia Type 11; Spinocerebellar Ataxia Type 10; Spinocerebellar Ataxia Type 1 With Axonal Neuropathy; Spinocerebellar Ataxia Type 1; Spinocerebellar Ataxia - Unknown; Spinocerebellar Ataxia - Dysmorphism; Non Progressive Epilepsy and/or Ataxia With Myoclonus as a Major Feature; Spectrin-associated Autosomal Recessive Cerebellar Ataxia; Spasticity-ataxia-gait Anomalies Syndrome; Spastic Ataxia With Congenital Miosis; Spastic Ataxia - Corneal Dystrophy; Spastic Ataxia; Rare Hereditary Ataxia; Rare Ataxia; Recessive Mitochondrial Ataxia Syndrome; Progressive Epilepsy and/or Ataxia With Myoclonus as a Major Feature; Posterior Column Ataxia - Retinitis Pigmentosa; Post-Stroke Ataxia; Post-Head Injury Ataxia; Post Vaccination Ataxia; Polyneuropathy - Hearing Loss - Ataxia - Retinitis Pigmentosa - Cataract; Muscular Atrophy - Ataxia - Retinitis Pigmentosa - Diabetes Mellitus; Non-progressive Cerebellar Ataxia With Intellectual Disability; Non-hereditary Degenerative Ataxia; Paroxysmal Dystonic Choreathetosis With Episodic Ataxia and Spasticity; Olivopontocerebellar Atrophy - Deafness; NARP Syndrome; Myoclonus - Cerebellar Ataxia - Deafness; Multiple System Atrophy, Parkinsonian Type; Multiple System Atrophy, Cerebellar Type; Multiple System Atrophy; Maternally-inherited Leigh Syndrome; Machado-Joseph Disease Type 3; Machado-Joseph Disease Type 2; Machado-Joseph Disease Type 1; Lethal Ataxia With Deafness and Optic Atrophy; Leigh Syndrome; Leukoencephalopathy With Mild Cerebellar Ataxia and White Matter Edema; Leukoencephalopathy - Ataxia - Hypodontia - Hypomyelination; Leigh Syndrome With Nephrotic Syndrome; Leigh Syndrome With Leukodystrophy; Leigh Syndrome With Cardiomyopathy; Late-onset Ataxia With Dementia; Intellectual Disability-hyperkinetic Movement-truncal Ataxia Syndrome; Infection or Post Infection Ataxia; Infantile-onset Autosomal Recessive Nonprogressive Cerebellar Ataxia; Infantile Onset Spinocerebellar Ataxia; GAD Ataxia; Hereditary Episodic Ataxia; Gliadin/Gluten Ataxia; Friedreich Ataxia; Fragile X-associated Tremor/Ataxia Syndrome; Familial Paroxysmal Ataxia; Exposure to Medications Ataxia; Episodic Ataxia With Slurred Speech; Episodic Ataxia Unknown Type; Episodic Ataxia Type 7; Episodic Ataxia Type 6; Episodic Ataxia Type 5; Episodic Ataxia Type 4; Episodic Ataxia Type 3; Episodic Ataxia Type 1; Epilepsy and/or Ataxia With Myoclonus as Major Feature; Early-onset Spastic Ataxia-neuropathy Syndrome; Early-onset Progressive Neurodegeneration - Blindness - Ataxia - Spasticity; Early-onset Cerebellar Ataxia With Retained Tendon Reflexes; Early-onset Ataxia With Dementia; Childhood-onset Autosomal Recessive Slowly Progressive Spinocerebellar Ataxia; Dilated Cardiomyopathy With Ataxia; Cataract - Ataxia - Deafness; Cerebellar Ataxia, Cayman Type; Cerebellar Ataxia With Peripheral Neuropathy; Cerebellar Ataxia - Hypogonadism; Cerebellar Ataxia - Ectodermal Dysplasia; Cerebellar Ataxia - Areflexia - Pes Cavus - Optic Atrophy - Sensorineural Hearing Loss; Brain Tumor Ataxia; Brachydactyly - Nystagmus - Cerebellar Ataxia; Benign Paroxysmal Tonic Upgaze of Childhood With Ataxia; Autosomal Recessive Syndromic Cerebellar Ataxia; Autosomal Recessive Spastic Ataxia With Leukoencephalopathy; Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay; Autosomal Recessive Spastic Ataxia - Optic Atrophy - Dysarthria; Autosomal Recessive Spastic Ataxia; Autosomal Recessive Metabolic Cerebellar Ataxia; Autosomal Dominant Spinocerebellar Ataxia Due to Repeat Expansions That do Not Encode Polyglutamine; Autosomal Recessive Ataxia, Beauce Type; Autosomal Recessive Ataxia Due to Ubiquinone Deficiency; Autosomal Recessive Ataxia Due to PEX10 Deficiency; Autosomal Recessive Degenerative and Progressive Cerebellar Ataxia; Autosomal Recessive Congenital Cerebellar Ataxia Due to MGLUR1 Deficiency; Autosomal Recessive Congenital Cerebellar Ataxia Due to GRID2 Deficiency; Autosomal Recessive Congenital Cerebellar Ataxia; Autosomal Recessive Cerebellar Ataxia-pyramidal Signs-nystagmus-oculomotor Apraxia Syndrome; Autosomal Recessive Cerebellar Ataxia-epilepsy-intellectual Disability Syndrome Due to WWOX Deficiency; Autosomal Recessive Cerebellar Ataxia-epilepsy-intellectual Disability Syndrome Due to TUD Deficiency; Autosomal Recessive Cerebellar Ataxia-epilepsy-intellectual Disability Syndrome Due to KIAA0226 Deficiency; Autosomal Recessive Cerebellar Ataxia-epilepsy-intellectual Disability Syndrome; Autosomal Recessive Cerebellar Ataxia With Late-onset Spasticity; Autosomal Recessive Cerebellar Ataxia Due to STUB1 Deficiency; Autosomal Recessive Cerebellar Ataxia Due to a DNA Repair Defect; Autosomal Recessive Cerebellar Ataxia - Saccadic Intrusion; Autosomal Recessive Cerebellar Ataxia - Psychomotor Retardation; Autosomal Recessive Cerebellar Ataxia - Blindness - Deafness; Autosomal Recessive Cerebellar Ataxia; Autosomal Dominant Spinocerebellar Ataxia Due to a Polyglutamine Anomaly; Autosomal Dominant Spinocerebellar Ataxia Due to a Point Mutation; Autosomal Dominant Spinocerebellar Ataxia Due to a Channelopathy; Autosomal Dominant Spastic Ataxia Type 1; Autosomal Dominant Spastic Ataxia; Autosomal Dominant Optic Atrophy; Ataxia-telangiectasia Variant; Ataxia-telangiectasia; Autosomal Dominant Cerebellar Ataxia, Deafness and Narcolepsy; Autosomal Dominant Cerebellar Ataxia Type 4; Autosomal Dominant Cerebellar Ataxia Type 3; Autosomal Dominant Cerebellar Ataxia Type 2; Autosomal Dominant Cerebellar Ataxia Type 1; Autosomal Dominant Cerebellar Ataxia; Ataxia-telangiectasia-like Disorder; Ataxia-intellectual Disability-oculomotor Apraxia-cerebellar Cysts Syndrome; Ataxia-deafness-intellectual Disability Syndrome; Ataxia With Vitamin E Deficiency; Ataxia With Dementia; Ataxia Neuropathy Spectrum; Ataxia - Tapetoretinal Degeneration; Ataxia - Photosensitivity - Short Stature; Ataxia - Pancytopenia; Ataxia - Oculomotor Apraxia Type 1; Ataxia - Hypogonadism - Choroidal Dystrophy; Ataxia - Other; Ataxia - Genetic Diagnosis - Unknown; Acquired Ataxia; Adult-onset Autosomal Recessive Cerebellar Ataxia; Alcohol Related Ataxia; Multiple Endocrine Neoplasia; Multiple Endocrine Neoplasia Type II; Multiple Endocrine Neoplasia Type 1; Multiple Endocrine Neoplasia Type 2; Multiple Endocrine Neoplasia, Type IV; Multiple Endocrine Neoplasia, Type 3; Multiple Endocrine Neoplasia (MEN) Syndrome; Multiple Endocrine Neoplasia Type 2B; Multiple Endocrine Neoplasia Type 2A; Atypical Hemolytic Uremic Syndrome; Atypical HUS; Wiedemann-Steiner Syndrome; Breast Implant-Associated Anaplastic Large Cell Lymphoma; Autoimmune/Inflammatory Syndrome Induced by Adjuvants (ASIA); Hemophagocytic Lymphohistiocytosis; Behcet's Disease
NASA Astrophysics Data System (ADS)
Gallo, E. M.; Hogue, T. S.; Gold, M.; Mika, K.
2016-12-01
Dominguez Channel and Machado Lake watersheds are located in highly urbanized southern Los Angeles County. The 16 mile long channel that runs through the Dominguez Channel watershed (DCW) captures stormwater from a drainage area of 71 square miles and discharges directly into the Los Angeles Harbor. Machado Lake, located within the Machado Lake watershed (MLW) and directly adjacent to DCW, has a surface area of 40 acres and receives stormwater from 25 square miles. The water quality of receiving streams and waterbodies in DCW and MLW are increasingly polluted from stormwater runoff and highly concentrated areas of industrial activities. The main concern of water impairment within DCW includes copper and zinc while MLW is focused on nutrients, Total Nitrogen and Total Phosphorous. The implementation of Low Impact Developments (LIDs) and stormwater Best Management Practices (BMPs) within the watershed aim to mitigate the effects of urbanization by reducing pollutant loads, runoff volume, and storm peak flow. We utilize the EPA System for Urban Stormwater Treatment and Analysis INtegration (SUSTAIN) model in order to assess the impact of BMPs within the DCW and MLW watersheds by forecasting flow regimes and water quality time series data. Six compliance scenarios are simulated in SUSTAIN to assess pollutant load reduction and cost effectiveness. They each utilize a various suite of the five BMPs selected, which include vegetated swales, bioretention cells, dry ponds, infiltration trenches and porous pavement. Preliminary results show that while the six compliance options reduce pollutant loads by at least 73% in DCW, copper and zinc are only 9% and 50% in compliance, respectively, in terms of the wet weather TMDLs. This study further analyzes these results by comparing DCW to other previously modelled watersheds in Los Angeles, including Ballona Creek watershed and the Los Angeles River watershed. Observed water quality sampling from Machado Lake has shown the mean concentrations of nutrients well above the TMDLs. Machado Lake is currently being restored which includes the implementation BMPs. While the DCW is being modeled to determine the best scenarios for future BMP implementation, MLW is modeled to assess the efficacy of current BMPs to meet TMDL compliance.
Oda, Masaya; Maruyama, Hirofumi; Komure, Osamu; Morino, Hiroyuki; Terasawa, Hideo; Izumi, Yuishin; Imamura, Tohru; Yasuda, Minoru; Ichikawa, Keiji; Ogawa, Masafumi; Matsumoto, Masayasu; Kawakami, Hideshi
2004-02-01
Spinocerebellar ataxia type 17 (SCA17) is an autosomal dominant cerebellar ataxia caused by expansion of CAG/CAA trinucleotide repeats in the TATA-binding protein (TBP) gene. Because the number of triplets in patients with SCA17 in previous studies ranged from 43 to 63, the normal number of trinucleotide units has been considered to be 42 or less. However, some healthy subjects in SCA17 pedigrees carry alleles with the same number of expanded repeats as patients with SCA17. To investigate the minimum number of CAG/CAA repeats in the TBP gene that causes SCA17. We amplified the region of the TBP gene containing the CAG/CAA repeat by means of polymerase chain reaction and performed fragment and sequence analyses. The subjects included 734 patients with SCA (480 patients with sporadic SCA and 254 patients with familial SCA) without CAG repeat expansions at the SCA1, SCA2, Machado-Joseph disease, SCA6, SCA7, or dentatorubral-pallidolluysian atrophy loci, with 162 healthy subjects, 216 patients with Parkinson disease, and 195 with Alzheimer disease as control subjects. Eight patients with SCA possessed an allele with more than 43 CAG/CAA repeats. Among the non-SCA groups, alleles with 43 to 45 repeats were seen in 3 healthy subjects and 2 with Parkinson disease. In 1 SCA pedigree, a patient with possible SCA17 and her healthy sister had alleles with 45 repeats. A 34-year-old man carrying alleles with 47 and 44 repeats (47/44) had developed progressive cerebellar ataxia and myoclonus at 25 years of age, and he exhibited dementia and pyramidal signs. He was the only affected person in his pedigree, although his father and mother carried alleles with mildly expanded repeats (44/36 and 47/36, respectively). In another pedigree, 1 patient carried a 43-repeat allele, whereas another patient had 2 normal alleles, indicating that the 43-repeat allele may not be pathologic in this family. We estimate that 44 CAG/CAA repeats is the minimum number required to cause SCA17. However, the existence of unaffected subjects with mildly expanded triplets suggests that the TBP gene mutation may not penetrate fully. Homozygosity of alleles with mildly expanded triplet repeats in the TBP gene might contribute to the pathologic phenotype.
Was the real Sherlock Holmes a pediatric surgeon?
Raffensperger, John
2010-07-01
This article reviews the pioneering efforts of Joseph Bell, the model for Sherlock Holmes, in the surgical care of children during the antiseptic era. I reviewed biographies of Sir Arthur Conan Doyle; the biography of Joseph Bell; his surgical textbook, Edinburgh Medical Journals; and the history of the Royal Edinburgh Hospital for Sick Children. Dr Bell was a colleague of Joseph Lister and one of the first surgeons to apply antiseptic methods to operations involving children. He was the surgeon appointed to the first surgical ward of the Royal Edinburgh Hospital for Sick Children; in that role, he cared for many children with surgical diseases. Dr Joseph Bell, by his compassion for children and his surgical skill, was indeed a pioneer pediatric surgeon. Copyright 2010 Elsevier Inc. All rights reserved.
75 FR 15430 - Chief Joseph Hatchery Program
Federal Register 2010, 2011, 2012, 2013, 2014
2010-03-29
...: Bonneville Power Administration (BPA), Department of Energy (DOE). ACTION: Notice of availability of Record... proposed action identified in BPA's Chief Joseph Hatchery Program Environmental Impact Statement (DOE/EIS-0384, November 2009). BPA has decided to fund the construction, operation, and maintenance of the Chief...
Larva of Palaemnema brasiliensis Machado (Odonata: Platystictidae), from Amazonas, Brazil.
Neiss, Ulisses Gaspar; Hamada, Neusa
2016-02-09
The larva of Palaemnema brasiliensis Machado, 2009 is described and illustrated based on last-instar larvae and exuviae of reared larvae collected in a blackwater stream in Barcelos and Presidente Figueiredo municipalities, Amazonas state, Brazil. The larva of P. brasiliensis can be distinguished from the two South American species of the genus with described larvae (P. clementia Selys and P. mutans Calvert), mainly by presence of a single obtuse cusp on the labial palp, the presence and configuration of setae in the caudal lamellae, and the proportional length of terminal filaments of the caudal lamellae. The family is recorded here for the first time in Brazilian state of Amazonas.
Reis, José Roberto Franco
2016-01-01
From the early 1970s until more recently, historiography (which is not always written by historians) has investigated the psychiatric intervention practices that prevailed in Brazil from the latter half of the nineteenth century through the early twentieth, along with their theoretical foundations and the underlying logics of power and sociability. The article analyzes the novella "The Alienist," by Machado de Assis, by engaging in dialogue with this field. The book is interpreted as a robust and eminently critical "historical witness" of the early emergence of mental health medicine in Brazil and its institutional correlate, the asylum.
Sister Mary Joseph's nodule as the first presenting sign of primary fallopian tube adenocarcinoma.
Kirshtein, Boris; Meirovitz, Mihai; Okon, Elimelech; Piura, Benjamin
2006-01-01
Umbilical metastasis (Sister Mary Joseph's nodule) is often the first sign of intraabdominal and/or pelvic carcinoma. We describe the fourth case reported in the literature of Sister Mary Joseph's nodule originating from fallopian tube carcinoma. In a 54-year-old woman, Sister Mary Joseph's nodule was unexpectedly detected during umbilical hernia repair. Subsequent laparoscopy revealed a 2-cm friable tumor located at the fimbriated end of right fallopian tube and 1-cm peritoneal implant in the pouch of Douglas. Laparoscopic bilateral adnexectomy and resection of the peritoneal implant were performed. Because frozen section examination revealed fallopian tube carcinoma, the procedure was continued with laparotomy including total abdominal hysterectomy, omentectomy, and pelvic lymph node sampling. Final diagnosis was stage IIIB fallopian tube carcinoma. The patient received postoperative adjuvant chemotherapy with single-agent carboplatin and has remained alive and with no evidence of disease. It is concluded that in cases of Sister Mary Joseph's nodule, laparoscopy can be a useful tool in the search of the primary tumor in the abdomen and/or pelvis. Laparoscopy can provide crucial information with respect to the location, size, and feasibility of optimal surgical resection of the intraabdominal and/or pelvic tumors.
Salemis, Nikolaos S
2007-01-01
Umbilical metastasis (Sister Mary Joseph's nodule) is a rare occurrence and indicates, in most of the patients, an advanced intraabdominal malignancy. It may be the first sign of an underlying adenocarcinoma, originating mainly from the gastrointestinal or genitourinary tract. An extremely rare case of a Sister Mary Joseph's nodule is described herein, where the metastatic umbilical nodule was the first sign of a cecal adenocarcinoma and became evident 8 months before the onset of the disease. Diagnostic evaluation and surgical management are discussed along with a review of the literature. This case is presented in order to emphasize the need for thorough investigation of any umbilical lesion especially in elderly patients.
Essential Tremor vs. Parkinson's Disease: How Do They Differ?
... Arif Herekar , MD, Chairman and Head, Department of Neurology, Baqai Medical University; and member of the IETF Medical Advisory Board. Joseph Jankovic , MD, Professor of Neurology, Distinguished Chair in Movement Disorders, Director, Parkinson’s Disease ...
ERIC Educational Resources Information Center
Frith, Luci A.
In "The Hero's Journey" Joseph Campbell identifies the patterns that inform the myths of the "hero" throughout recorded history. By using Campbell's template, this paper examines how the American war hero is portrayed and has been portrayed in film. The paper states that Americans not only define their war heroes in films but…
DR AVRAM JOZEF VINAVER (1862-1915) - PIONEER OF RADIOLOGY IN SERBIA.
Babić, Rade Radomir; Stanković Babić, Gordana
2015-01-01
Dr Abraham Joseph Vinaver (1862-1915), a Jew from Poland, was a pioneer of radiology in Serbia. He graduated from the Faculty of Medicine in Warsaw (1887), but lived and worked in abac (the Kingdom of Serbia) since 1890. Dr Abraham Joseph Vinarev - Career Development. He procured the first X-ray machine and developed radiological service in Sabac five years after the discovery of X-rays. These were the beginnings of radiology in Serbia. He introduced the application of artesian wells. Dr Abraham Joseph Vinarev - a Participant at the First Congress of Serbian Physicians and Naturalists, Belgrade 1904. "The diagnostic importance of X-rays in lung disease, especially in initial tuberculosis" and "Five Years of Treatment by X-Ray Machines" were the first works in the field of radiology in Serbia by this author. Dr Abraham Joseph Vinaver - Reserve Medical Officer in the Serbian Army. During the Balkan Wars, he was a volunteer with the rank of major engaged in military corps and he participated in the First World War as well. He died of malaria in 1915 in Gevgelija. "Dr Avram Vinaver"- Stanislav Vinarev. His dedication to work during the typhus epidemics was put into verses of a poem by his son Stanislav Vinarev. Dr Avram Vinaver Joseph was a noble man with a great heart, who selflessly sacrificed himself for the Serbian people and Serbia. He gave his contribution to the development of health services in Serbia, both in peacetime and wartime conditions. Dr Abraham Joseph Vinaver laid the foundations for today's radiology in Serbia.
Bayless, E. Randall; Westjohn, David B.; Watson, Lee R.
1995-01-01
Inverse models of direct current electrical- resistivity sounding data and normal-resistivity and natural-gamma logs were used to assist delineation of the glacial-drift stratigraphy in a 580-square- kilometer area of northeastern St. Joseph County, Indiana. Unconsolidated deposits in the study area are composed of glacial-drift, including outwash, till, and lacustrine sediments; thicknesses range from about 15 to more than 70 meters. The glacial outwash deposits are mostly composed of sand and gravel and are the primary source of drinking water to northeastern St. Joseph County. The glacial till and glacio-lacustrine deposits contain a larger fraction of clay than the outwash deposits and may retard ground-water flow between shallow and deeper sand and gravel aquifers. Results of the geophysical measurements collected during this study indicate that glacial-drift deposits in the area north and east of the St. Joseph River are mostly composed of sand and gravel with inter-layered clay-rich deposits that are laterally discontinuous. In the area south of the St. Joseph River, the thickness of sand and gravel deposits diminishes, and clay-rich deposits dominate the stratigraphy. The presence of an electrically conductive bedrock, the Ellsworth Shale, beneath the glacial-drift deposits is identified in inverse models of direct current electrical-resistivity sounding data.
... Cassini Catalano Caviness Cazden Chait Cham Chambi Chan Chang Charles Charness Charous Charpied Cheng Chhetri Childers Chitkara ... Lynch Lyons Machado Maciunas Mahant Mahon Majewski Malhado-Chang Mangels Mann Manning Sifers Maragos Marantz Marcus Marden ...
... More for Teens Teens site Sitio para adolescentes Body Mind Sexual Health Food & Fitness Diseases & Conditions Infections Drugs & ... methods from around the world, among them the mind-body formats of yoga and Chinese martial arts. Joseph ...
The Human Proteome Organization (HUPO) has released a video of the keynote speech given by the 47th Vice President of the United States of America Joseph R. Biden Jr. at the HUPO2017 Global Leadership Gala. Under the gala theme “International Cooperation in the Fight Against Cancer,” Biden recognized cancer as a collection of related diseases, the importance of data sharing and harmonization, and the need for collaboration across scientific disciplines as inflection points in cancer research.
Towards Link Characterization from Content
2008-01-01
S.D. Walter and L.M. Irwig, “Estimation of Test Error Rates, Disease Prevalence , and Relative Risk from Misclas- sified Data: A Review,” Journal of...Clinical Epidemiology, vol. 41, pp. 923–937, 1988. [10] L. Joseph, T. Gyorkos, and L. Coupal, “Bayesian estimation of disease prevalence and the
2016-09-29
Lithium and Lithium - Ion Batteries September 29, 2016 Approved for public release; distribution is unlimited. Joseph F. parker JeFFrey W. Long Surface...Boundaries of Navy and Marine Corps Lithium and Lithium - Ion Batteries Joseph F. Parker, Jeffrey W. Long, Olga A. Baturina, and Corey T. Love Naval...U.S. Marine Corps have identified a strategic interest to operate lithium - ion batteries in cold climate regions as well as undersea and in high
NASA Astrophysics Data System (ADS)
Burnham, A. D.; Bulanova, G. P.; Smith, C. B.; Whitehead, S. C.; Kohn, S. C.; Gobbo, L.; Walter, M. J.
2016-11-01
Diamonds from the Machado River alluvial deposit have been characterised on the basis of external morphology, internal textures, carbon isotopic composition, nitrogen concentration and aggregation state and mineral inclusion chemistry. Variations in morphology and features of abrasion suggest some diamonds have been derived directly from local kimberlites, whereas others have been through extensive sedimentary recycling. On the basis of mineral inclusion compositions, both lithospheric and sublithospheric diamonds are present at the deposit. The lithospheric diamonds have clear layer-by-layer octahedral and/or cuboid internal growth zonation, contain measurable nitrogen and indicate a heterogeneous lithospheric mantle beneath the region. The sublithospheric diamonds show a lack of regular sharp zonation, do not contain detectable nitrogen, are isotopically heavy (δ13CPDB predominantly - 0.7 to - 5.5) and contain inclusions of ferropericlase, former bridgmanite, majoritic garnet and former CaSiO3-perovskite. This suggests source lithologies that are Mg- and Ca-rich, probably including carbonates and serpentinites, subducted to lower mantle depths. The studied suite of sublithospheric diamonds has many similarities to the alluvial diamonds from Kankan, Guinea, but has more extreme variations in mineral inclusion chemistry. Of all superdeep diamond suites yet discovered, Machado River represents an end-member in terms of either the compositional range of materials being subducted to Transition Zone and lower mantle or the process by which materials are transferred from the subducted slab to the diamond-forming region.
Hernández, Victor M Q; Barreat, José G N
2017-10-31
The genus Racekiela Bass & Volkmer-Ribeiro, 1998 comprises six species of freshwater sponges distributed along the Palaearctic, Nearctic and Neotropical regions (Van Soest et al. 2017). They are characterized by an isodictyal skeleton solely of acanthoxeas, sparse spongin fibers, and tri-layered gemmules with radially embedded gemmoscleres of two types, short birotules and long pseudobirotules (Manconi & Pronzato 2002; Volkmer-Ribeiro & Machado 2007). Four species occur in the Northern Hemisphere: R. biceps (Lindenschmidt, 1950) from Michigan (Lindenschmidt 1950), R. pictouensis (Potts, 1885) from eastern Canada to New York (Penney & Racek 1968), R. ryderii (Potts, 1882) which ranges from eastern North America to the British Isles, Faroes and Norway (Manconi & Pronzato 2002), and the recently described R. montemflumina Carballo, Cruz-Barraza, Yáñez & Gómez, 2017 from Northwestern Mexico (Carballo et al. 2017). It is worthy to note that R. pictouensis is considered to be an ecomorph of R. ryderii by several authors (Porrier 1977; Ricciardi & Reiswig 1993). The other two species, R. cavernicola (Volkmer-Ribeiro, Bichuette & Machado, 2010) and R. sheilae (Volkmer-Ribeiro, De Rosa-Barbosa & Tavares, 1988), are both known only from Brazil (Volkmer-Ribeiro & Machado 2007; Volkmer-Ribeiro et al. 2010). Here we describe a new member of the genus, found in lakes of high-mountain ecosystems, or páramos, in the Cordillera de Mérida. This constitutes the first record of specimens belonging to Racekiela for the Andes and Venezuela.
NASA Astrophysics Data System (ADS)
Katugampola, Udita N.
2016-09-01
There is a debate among contemporary mathematicians about what it really means by a fractional derivative. The question arose as a consequence of introducing a 'new' definition of a fractional derivative in [1]. In a reply, Ortigueira and Machado [2] came up with several very important criteria to determine whether a given derivative is a fractional derivative. According to their criterion, the new fractional derivative, called conformable fractional derivative, introduced by Khalil et al. [1] turns out not to be a fractional derivative, but rather a controlled or conformable derivative. In proving the claim the authors in [2] use an example [2, p. 6]. It turns out that the explanation given there needs some corrections and it is the sole purpose of this note.
On the classification of diseases.
Smart, Benjamin
2014-08-01
Identifying the necessary and sufficient conditions for individuating and classifying diseases is a matter of great importance in the fields of law, ethics, epidemiology, and of course, medicine. In this paper, I first propose a means of achieving this goal, ensuring that no two distinct disease-types could correctly be ascribed to the same disease-token. I then posit a metaphysical ontology of diseases-that is, I give an account of what a disease is. This is essential to providing the most effective means of interfering with disease processes. Following existing work in the philosophy of medicine and epidemiology (primarily Christopher Boorse; Caroline Whitbeck; Alexander Broadbent), philosophy of biology (Joseph LaPorte; D.L. Hull), conditional analyses of causation (J.L. Mackie; David Lewis), and recent literature on dispositional essentialism (Stephen Mumford and Rani Anjum; Alexander Bird), I endorse a dispositional conception of disease. Following discussion of various conceptions of disease-identity, their relations to the clinical and pathological effects of the diseases in question, and how diseases are treated, I conclude (i) that diseases should be individuated by their causes, and (ii) that diseases are causal processes best seen as simultaneously acting sequences of mutually manifesting dispositions.
Annual Research Progress Report, Fiscal Year 1981,
1981-10-01
Joseph P. Murgo, M.D., COL, MC Key Words: Patent ductus arteriosus Cyanotic congenital heart disease Accumulative MEDCASE Est Accumulative Periodic Cost... Ductus Arteriosus in Neonates 47 with Cyanotic Congenital Heart Disease. (T) C-37-79 Ankle Trauma Study. (0) 48 C-5-80 Lopressor Intervention Trial. (0...Maintenance of Patency of the Ductus Arteriosus in Neonates with Cyanotic Congenital Heart Disease Start Date: Aug 79 Est Comp Date: Principal
Federal Register 2010, 2011, 2012, 2013, 2014
2013-08-16
....R50000] Notice of Inventory Completion: St. Joseph County Sheriff's Department, Centreville, MI AGENCY: National Park Service, Interior. ACTION: Notice. SUMMARY: The St. Joseph County Sheriff's Department has... control of these human remains should submit a written request to the St. Joseph County Sheriff's...
Rethinking Joseph Janangelo's "Joseph Cornell and the Artistry of Composing Persuasive Hypertexts"
ERIC Educational Resources Information Center
College Composition and Communication, 2007
2007-01-01
This article presents several excerpts from an article written by Joseph Janangelo titled "Joseph Cornell and the Artistry of Composing Persuasive Hypertexts." In his article, Janangelo suggested that Cornell's work and ideas about composing model intelligent ways to composing persuasive nonsequential text. Janangelo also wondered if the use of…
78 FR 73749 - Proposed Amendment of Class D Airspace; St. Joseph, MO
Federal Register 2010, 2011, 2012, 2013, 2014
2013-12-09
...-0917; Airspace Docket No. 13-ACE-16] Proposed Amendment of Class D Airspace; St. Joseph, MO AGENCY... action proposes to amend Class D airspace at St. Joseph, MO. Additional controlled airspace is necessary... Rosecrans Municipal Airport, St. Joseph, MO. Accordingly, additional segments would extend from the 4.3-mile...
33 CFR 117.651 - St. Joseph River.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false St. Joseph River. 117.651 Section... DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Michigan § 117.651 St. Joseph River. The draws of the US33 (Blossomland) bridge, mile 0.9, and the BL-94 (Bicentennial) bridge, mile 1.3, both at St. Joseph...
46 CFR 45.183 - Load line requirements for the St. Joseph and Muskegon routes.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 46 Shipping 2 2010-10-01 2010-10-01 false Load line requirements for the St. Joseph and Muskegon... requirements for the St. Joseph and Muskegon routes. (a) Load line certificate. (1) The load line issued under... certificate is valid for the St. Joseph and Muskegon routes, and intermediate ports. However, operators must...
Perry, R.W.; Farley, M.J.; Hansen, G.S.; Shurtleff, D.J.; Rondorf, D.W.; LeCaire, R.
2003-01-01
In 1995, the Chief Joseph Kokanee Enhancement Project was established to mitigate the loss of anadromous fish due to the construction of Chief Joseph and Grand Coulee dams. The objectives of the Chief Joseph Enhancement Project are to determine the status of resident kokanee (Oncorhynchus nerka) populations above Chief Joseph and Grand Coulee dams and to enhance kokanee and rainbow trout (Oncorhynchus mykiss) populations. Studies conducted at Grand Coulee Dam documented substantial entrainment of kokanee through turbines at the third powerhouse.
Ball, Christine M
2016-08-26
The London surgeon and anaesthetist, Joseph Thomas Clover (1825-1882), and the Birmingham surgeon, Joseph Sampson Gamgee (1828-1886), are well known figures in the history of medicine. Draft letters among the surviving papers of Joseph Clover have been transcribed and reveal new information about their friendship, their financial affairs and Clover's motivation to become a full-time anaesthetist. They have also led to the discovery that Gamgee was briefly imprisoned in Warwick County Goal for debt in 1859. © The Author(s) 2016.
Joseph Haydn's encephalopathy: new aspects.
Blahak, Christian; Bäzner, Hansjörg; Hennerici, Michael G
2015-01-01
With increasing age, Joseph Haydn complained of progressive forgetfulness preventing him from composing for about the last 8 years of his life. He spent his days more and more inactive and immobilized, suffering from a disabling gait disturbance. Still, most biographers consider diffuse atherosclerosis and congestive heart failure to be reasons for Haydn's medical condition and physical decline during the last years of his life. A more sophisticated and detailed inspection of documents and sources, however, leads to the diagnosis of subcortical vascular encephalopathy (SVE), caused by progressive cerebral small vessel disease. Important features of the disease are mood changes, urinary symptoms, and in particular a characteristic gait disturbance, while dementia is only mild and occurs later in the course. Haydn was severely disabled by the symptoms of SVE for several years and often reported difficulties in the completion of his last oratorio "Die Jahreszeiten" (The Seasons). Subsequently, the disease prevented him from composing another large oratorio, "Das jüngste Gericht" (The last judgement), which had been already drafted. Finally, the progress of SVE stopped his long career as a composer and conductor at the age of 73 years. © 2015 Elsevier B.V. All rights reserved.
Globalized Students vs. Unglobalized Families: Limiting Family Participation in Education
ERIC Educational Resources Information Center
Machado-Casas, Margarita; Ruiz, Elsa
2012-01-01
In today's society, the use technology is no longer a luxury but a need (Machado-Casas, 2009; Sanchez, 2010). Considering this, countless education stakeholders have explored the concept of the "digital divide", the gap that exists between people who have access to digital technology and those who do not. Oftentimes, this divide exists…
ERIC Educational Resources Information Center
Dominic, Joseph F.; And Others
1983-01-01
With regard to the preceding articles in this issue, Joseph F. Dominic identifies key ideas of the research on writing, Susan Florio-Ruane points out similarities and differences among the articles, and Nancy L. Stein discusses methodological and conceptual issues in writing research. (RH)
A Multi-Scale Modeling and Experimental Program for the Dynamic Mechanical Response of Tissue
2014-12-09
diseases ”. Speaker, Session Chair of Pathological Fibrils, American Crystallographic Association, Albuquerque NM, May 2014. Joseph Orgel (7...Nonlinear, Soft Matter Phys., vol. 73, no. 3, p. 031901, Mar. 2006. [4] S. Münster, L. M. Jawerth, B. a Leslie, J. I. Weitz, B. Fabry , and D. a Weitz
Federal Register 2010, 2011, 2012, 2013, 2014
2012-09-05
..., Dallas, Texas 75201-2272: 1. Rebecca Watson Vizard, St. Joseph Louisiana; Michael Rene Vizard, St. Joseph... William Wade Watson, St. Joseph, Louisiana, (collectively known as the ``Vizard Family Group'') to retain...
6. View northeast of Ten Acre Lot with Joseph Fry ...
6. View northeast of Ten Acre Lot with Joseph Fry Farm complex (center) and Beehive House (right)in the background - Joseph Fry Farm Landscape, 2153 South County Trail Road (U.S. Route 2), East Greenwich, Kent County, RI
ERIC Educational Resources Information Center
Michalak, Laurence
This lesson about Islam and the Koran is intended for grade 6 or 7 core classrooms. The lesson plan uses the story of Joseph (not Joseph, the father of Jesus, but Joseph who was abandoned by his brothers in a pit) as told in the Koran. The lesson plan does not provide a translation of the story but indicates where one can be found on the Internet.…
NATURAL BIOATTENUATION OF TRICHLOROETHENE AT THE ST. JOSEPH, MICHIGAN SUPERFUND SITE
Data from the St. Joseph, Michigan, Superfund Site were used in a peer-reviewed video entitled "Natural Bioattenuation of Trichloroethene at the St. Joseph, Michigan Superfund Site." Computer visualizations of the data set show how trichloroethene, or TCE, can degrade under natu...
[Joseph Babinski: a complex personality].
Poirier, Jacques
2007-10-01
Joseph Babinski (1857-1932), a Paris hospital neurologist known for the discovery of his eponymous sign, was a highly complex personality. He was known as a handsome but silent "blue-eyed giant". His parents left Poland for Paris after the insurrection of 1848. Joseph and his elder brother Henri (1855-1931) were born in Paris and were therefore French, but they remained devoted to Poland. Joseph suffered from excruciating self-doubt and was meticulous. He was a reasoner and a righter of wrongs. Henri, who trained as a civil engineer at the French National School of Mines, prospected mineral, gold and diamond deposits in various countries. On his return to France at the end of the century, he wrote, under the pseudonym Ali-Bab, a monumental cookbook called "Gastronomie pratique", which was widely acclaimed Joseph and Henri, both unmarried, lived together and formed an inseparable couple. Joseph Babinski had no religious, political or ideological commitments. Some areas of his private life still remain rather shadowy.
Geographically Isolated Wetlands Research Workshop Summary
During the week of November 18–21, 2013, a team of research scientists from federal, academic, and non-profit research institutions across North America met at the Joseph W. Jones Ecological Research Center in Newton, Georgia to articulate the state of the science, identify...
Joseph Priestley and the Psychology of Style.
ERIC Educational Resources Information Center
Moran, Michael G.
Joseph Priestley, in his "A Course of Lectures on Oratory and Criticism," developed a psychological theory of style. The "Course" covers three main topics: traditional rhetorical arts of invention, arrangement, and style. Borrowing from the ideas of David Hartley, the association psychologist; Joseph Addison, the aesthetician;…
20. A PHOTO IMAGE OF THE NORTH BANK OF THE ...
20. A PHOTO IMAGE OF THE NORTH BANK OF THE ST. JOSEPH'S RIVER IN THE VICINITY OF THE BRIDGE. - County Line Bridge, Spanning St. Joseph River at State Route 219, 0.6 mile south of U.S. Route 20, Osceola, St. Joseph County, IN
77 FR 3797 - Joseph Deluca, D.O.; Dismissal of Proceeding
Federal Register 2010, 2011, 2012, 2013, 2014
2012-01-25
... DEPARTMENT OF JUSTICE Drug Enforcement Administration Joseph Deluca, D.O.; Dismissal of Proceeding On July 16, 2010, the Deputy Assistant Administrator, Office of Diversion Control, Drug Enforcement Administration, issued an Order to Show Cause to Joseph Deluca, D.O. (Registrant), of Coral Springs, Florida. The...
18. A VIEW EAST, SHOWING THE HEAVILY WOODED BANKS OF ...
18. A VIEW EAST, SHOWING THE HEAVILY WOODED BANKS OF THE ST. JOSEPH RIVER. THIS IS TYPICAL OF THE RIVERSIDE ENVIRONMENT OF THE BRIDGE. - County Line Bridge, Spanning St. Joseph River at State Route 219, 0.6 mile south of U.S. Route 20, Osceola, St. Joseph County, IN
Federal Register 2010, 2011, 2012, 2013, 2014
2012-10-10
... Northeastern Railroad Company--Abandonment Exemption--In Branch and St. Joseph Counties, MI Indiana... Branch County, Mich., and milepost 100.69 near Sturgis in St. Joseph County, Mich. (the Line). The Line... .'' Decided: October 2, 2012. By the Board, Rachel D. Campbell, Director, Office of Proceedings. Derrick A...
33 CFR 110.193a - St. Joseph Bay, Fla.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false St. Joseph Bay, Fla. 110.193a... ANCHORAGE REGULATIONS Anchorage Grounds § 110.193a St. Joseph Bay, Fla. (a) The anchorage grounds—(1... northeast of the north entrance channel to Port St. Joe, Florida. (2) Explosives Anchorage Area 2. A...
'The Elephant Man' as 'self' and 'other': the psycho-social costs of a misdiagnosis.
Ablon, J
1995-06-01
'The Elephant Man's Disease' acquired enormous notoriety through the portrayals of the life of Joseph Merrick, 'The Elephant Man', on American stage, screen and television. These portrayals, inspired by Ashley Montagu's book, The Elephant Man (1971) parleyed the designation of Merrick's condition into a household phrase, a metaphor for the grimmest extreme of ugliness. This paper explores the impact of 'The Elephant Man' as the chief referent and role model for persons who believed they shared the condition of neurofibromatosis 1, a neurological genetic disorder, which was erroneously believed at the time his story was popularized to have affected Joseph Merrick. Data were gathered through interviews with sixty affected individuals and families about their responses to the media representations of 'The Elephant Man'. Informants were recruited from three NF Support Groups and two urban hospital caseloads in Northern California.
NASA Astrophysics Data System (ADS)
Johnson, A. Ivan
On June 4, 1991, AGU Fellow Joseph Fairfield Poland died in a Sacramento, Calif., hospital at the age of 83 after a long fight with Parkinson's Disease. A recognized expert on land subsidence and a retiree from the U.S. Geological Survey's Water Resources Division, his death occurred only 2 weeks after the end of the 4th International Symposium on Land Subsidence, held in Houston, Tex. Frequently known as “Mr. Land Subsidence,” it was appropriate that the proceedings of that symposium had been dedicated to him.Born in Boston, Poland earned a bachelor's degree in geology from Harvard University in 1929. He was resident geologist for Tropical Oil Company in Colombia from 1929 to 1931. After returning to the United States, Poland earned his master's degree in geology from Stanford University in 1935, taught groundwater hydrology, and consulted on groundwater and geophysical problems in the West and Southwest.
Ofelia Rodríguez Acosta and the Quest for National Solidarity in Cuba
ERIC Educational Resources Information Center
Ortiz-Loyola, Brenda
2015-01-01
By the mid-1920s, the feminist movement was gaining strong support within Cuban society, at the same time that Cubans were growing discontent with the repression and corruption of Gerardo Machado's dictatorial regime. Within this context, women writers like Ofelia Rodríguez Acosta fused the feminist fight for women's rights with a nationalist…
On the Clarification of Concepts: A Reply to Gallistel (2007) and Lau (2007)
ERIC Educational Resources Information Center
Machado, Armando; Silva, Francisco J.
2007-01-01
The authors argue that some of C. R. Gallistel's and H. C. Lau's solutions to the problems raised in the article by A. Machado and F. J. Silva are unlikely, logically inconsistent, or at odds with empirical evidence. In particular, Lau seems not to appreciate the necessity of clear and consistent psychological constructs before trying to map these…
Flawed foundations of associationism? Comments on Machado and Silva (2007).
Gallistel, C R
2007-10-01
A. Machado and F. J. Silva have spotted an important conceptual problem in scalar expectancy theory's account of the 2-standard-interval time-left experiment. C. R. Gallistel and J. Gibbon (2000) were aware of it but did not discuss it for historical and sociological reasons, owned up to in this article. A problem of broader significance for psychology, cognitive science, neuroscience, and the philosophy of mind concerns the closely related concepts of a trial and of temporal pairing, which are foundational in associative theories of learning and memory. Association formation is assumed to depend on the temporal pairing of the to-be-associated events. In modeling it, theorists have assumed continuous time to be decomposable into trials. But life is not composed of trials, and attempts to specify the conditions under which two events may be regarded as temporally paired have never succeeded. Thus, associative theories of learning and memory are built on conceptual sand. Undeterred, neuroscientists have defined the neurobiology-of-memory problem as the problem of determining the cellular and molecular mechanism of association formation, and connectionist modelers have made it a cornerstone of their efforts. More conceptual analysis is indeed needed. Copyright 2007 APA, all rights reserved.
Tribes of Men: John Joseph Mathews and Indian Internationalism
ERIC Educational Resources Information Center
Lutenski, Emily
2012-01-01
In this article, the author discusses John Joseph Mathews and Indian internationalism. As an old man, Osage intellectual, writer, and historian, John Joseph Mathews recalled his expatriation from the United States during the 1920s. After growing up in Pawhuska, Oklahoma, seat of the Osage Nation, where he had been born in 1894 to a white mother…
Joseph's Story: A Case Study of Late-Onset Necrotizing Enterocolitis From Early Birth to Recovery.
Gephart, Sheila M; Martin, Laura B; Kijewski, Amy; Johnson, Scott R
2015-01-01
Although necrotizing enterocolitis (NEC) is often catastrophic among premature infants, most cases occur in the first month after birth. This case study presents Joseph's story about a 24-week surviving twin who developed severe NEC at 5 months of age just days before he was to go home. The purpose of this case study report is to place Joseph and his parents' experience in the context of what is known about NEC risk factors, clinical presentation, and treatment, and then to offer recommendations to healthcare professionals to support families from NEC diagnosis to recovery. Now 5 years old, Joseph continues to manage consequences of NEC including deafness, developmental delay, multiple food allergies, and recurrent gastrointestinal challenges from short gut syndrome. Although NEC struck late and kept Joseph in the neonatal intensive care unit for 228 days, its consequences remain with this resilient child and his family.
USDA-ARS?s Scientific Manuscript database
Through watershed scale research in the St. Joseph River watershed in the United States, farmed potholes have been identified as contributing to nutrient loading of streams. Most farmed potholes are drained with tile risers, which are direct conduits for runoff water and associated contaminants dire...
33 CFR 80.810 - Cape San Blas, FL to Perdido Bay, FL.
Code of Federal Regulations, 2010 CFR
2010-07-01
..., FL to Perdido Bay, FL. (a) A line drawn from St. Joseph Bay Entrance Range A Rear Light through St. Joseph Bay Entrance Range B Front Light to St. Joseph Point. (b) A line drawn across the mouth of Salt Creek as an extension of the general trend of the shoreline to continue across the inlet to St. Andrews...
Federal Register 2010, 2011, 2012, 2013, 2014
2010-08-16
... SECURITIES AND EXCHANGE COMMISSION [File No. 500-1] Atchison Casting Corp. (n/k/a Bradken-Atchison/St. Joseph, Inc.), CityFed Financial Corp., Divine, Inc. (n/k/a Enivid, Inc.), Genesis Worldwide, Inc... information concerning the securities of Atchison Casting Corp. (n/k/a Bradken-Atchison/St. Joseph, Inc...
Leader and Spokesman for a People in Exile: Chief Joseph and the Nez Perce
ERIC Educational Resources Information Center
Jain, Samvit
2009-01-01
This article discusses Chief Joseph's surrender that marked the beginning of his diplomatic stand for justice in Indian Territory, where his tribe was forcibly exiled in accordance with American Indian policy of the time. Joseph battled for the repatriation of the Nez Perce through protests and other legal means, winning the support of the growing…
Joseph Campbell, Jung, Anne Tyler, and "The Cards": The Spiritual Journey in "Searching for Caleb."
ERIC Educational Resources Information Center
Thomson, Karen M.
Joseph Campbell, Carl Jung, and Anne Tyler have all dealt with spiritual journeys and card reading in their writings. In his book "Tarot Revelations," Joseph Campbell discusses his first association with tarot cards, dating from 1943, when he was introduced to the symoblism of playing cards by his friend and mentor, Heinrich Zimmer. Carl…
Louwagie, M; Hertel, M
1997-01-01
When St. Joseph's Hospital in St. Paul, MN, owned and operated by the Sisters of St. Joseph of Carondelet, joined the ecumenical HealthEast healthcare system in 1987, many observers were skeptical of the venture's success. But an emphasis on their shared Judeo-Christian values has enabled the Catholic, Lutheran, and Baptist facilities to build a strong system. The beginnings of the merger were difficult, as facilities closed, others expanded their services, and staff shifted between them. An open communications policy between HealthEast leaders and staff members and dedication to the mission of healthcare that all the system facilities shared helped blend denominational identity and traditions at each member hospital and establish a corporate identity. The HealthEast system has adopted some of St. Joseph's policies and practices, particularly in the areas of mission, ethics, and spiritual care. HealthEast St. Joseph's has also benefited from being part of the HealthEast system, gaining a more diverse staff respectful of each others' beliefs, expanded spiritual care, and the means to continue serving its community. HealthEast plans to discontinue inpatient services at HealthEast St. Joseph's in downtown St. Paul and build a suburban facility, but the Sisters of St. Joseph of Carondelet are working with HealthEast to assess the downtown community's healthcare needs, especially among the homeless and immigrant populations, and ensure those needs will continue to be met.
Characterization of Spotted Fever Group Rickettsiae in Flea and Tick Specimens From Northern Peru
2004-11-01
D. Machado, and J. R. Coura. 1994. Rocky Mountain spotted fever in an endemic area in Minas Gerais, Brazil. Mem. Inst. Os- waldo Cruz 89:497–501. 12...Int. J. Syst. Bacteriol. 48(Pt 3):839–849. 19. Fuentes, L. 1986. Ecological study of Rocky Mountain spotted fever in Costa Rica. Am. J. Trop. Med. Hyg
Engineering Psychology Handbook AY 2012 - 2013
2012-08-01
in the department Awards Room. 2001 Honoree: Anastasia Piotrowski 2002 Honoree: Jennifer Smith 2003 Honoree: Joseph Mitek 2004 Honoree: Eric...MAJ Jennifer Bower jennifer.bower@us.army.mil COL Joseph P. DeAntona joseph.deantona@us.army.mil Dr. Gina Kolisinski MAJ Silas Martinez...of the document that you actually read (e.g., “ Craik and Tulving (as cited in Galotti, 1994) found that . . .”). Only the work that you actually
Strategic Stability in the Cold War: Lessons for Continuing Challenges
2011-01-01
Moltz, Daniel Moran, Thomas Parker, Joseph Pilat , Pavel Podvig, Brad Roberts, Michael Rühle, Diego Ruiz Palmer, Thomas Scheber, Mark Schneider, Paul...differ. As Joseph Pilat has observed, terrorist organizations “have historically mimicked states in key areas and are thus subject to constraints and...Press, 2008, p. 60. 62 Joseph F. Pilat , “Dissuasion of Terrorists and Other Non-State Actors”, Strategic Insights, Vol.III, Issue 10, October
The Impact of Advisor Outreach on Priority Registration
ERIC Educational Resources Information Center
McClure, Jennifer L.
2017-01-01
In 2015, Elgin Community College's Student Success Infrastructure used the book "Influencer: The New Science of Leading Change" (2013) by Joseph Grenny, Kerry Patterson, David Maxfield, Ron McMillan, and Al Switzler to help frame conversations about improving student success. One of the book's main concepts is using data to identify and…
Code of Federal Regulations, 2010 CFR
2010-07-01
... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Gulf of Mexico south and west of Apalachicola, San Blas, and St. Joseph bays; air-to-air firing practice range, Tyndall Air Force Base, Fla. 334... Apalachicola, San Blas, and St. Joseph bays; air-to-air firing practice range, Tyndall Air Force Base, Fla. (a...
Adaptation of Physiological and Cognitive Workload via Interactive Multi-modal Displays
2014-05-28
peer-reviewed journals (N/A for none) 09/07/2013 Received Paper 8.00 James Merlo, Joseph E. Mercado , Jan B.F. Van Erp, Peter A. Hancock. Improving...08, . : , Mr. Joseph Mercado , Mr. Timothy White, Dr. Peter Hancock. Effects of Cross-Modal Sensory Cueing Automation Failurein a Target Detection Task...fields:...... ...... ...... ...... ...... PERCENT_SUPPORTEDNAME FTE Equivalent: Total Number: Discipline Joseph Mercado 0.50 Timothy White 0.50 1.00 2
microRNA in Cerebral Spinal Fluid as Biomarkers of Alzheimer’s Disease Risk After Brain Injury
2017-08-01
anticipate that the regulatory delays will impact expenditures for this project. Significant changes in use or care of human subjects, vertebrate...PRINCIPAL INVESTIGATOR: Dr. Joseph Quinn CONTRACTING ORGANIZATION: Oregon Health & Science University Portland, OR 97239-3098 REPORT DATE: August 2017...7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBER OREGON HEALTH & SCIENCE UNIVERSITY
ERIC Educational Resources Information Center
Carlson, David Lee
2007-01-01
This commentary argues that Joseph Zins' work can contribute and enhance university-based teacher preparation programs. Focusing on secondary English Education, it examines how SEL competencies can improve the curricula and field experiences to support pre-service teachers.
3. HISTORIC AMERICAN BUILDINGS SURVEY JOSEPH T. GOLABOWSKI PHOTOGRAPHER ...
3. HISTORIC AMERICAN BUILDINGS SURVEY JOSEPH T. GOLABOWSKI - PHOTOGRAPHER - APRIL 10, 1934. SOUTH ELEVATION (FRONT) - Presbyterian Church, West Cherry & North Mechanic Streets, Winchester, Scott County, IL
NASA Astrophysics Data System (ADS)
Di Francesco, P.; Zinn-Justin, P.
2005-12-01
We prove higher rank analogues of the Razumov Stroganov sum rule for the ground state of the O(1) loop model on a semi-infinite cylinder: we show that a weighted sum of components of the ground state of the Ak-1 IRF model yields integers that generalize the numbers of alternating sign matrices. This is done by constructing minimal polynomial solutions of the level 1 U_q(\\widehat{\\frak{sl}(k)}) quantum Knizhnik Zamolodchikov equations, which may also be interpreted as quantum incompressible q-deformations of quantum Hall effect wavefunctions at filling fraction ν = k. In addition to the generalized Razumov Stroganov point q = -eiπ/k+1, another combinatorially interesting point is reached in the rational limit q → -1, where we identify the solution with extended Joseph polynomials associated with the geometry of upper triangular matrices with vanishing kth power.
1. HISTORIC AMERICAN BUILDINGS SURVEY JOSEPH T. GOLABOWSKI PHOTOGRAPHER ...
1. HISTORIC AMERICAN BUILDINGS SURVEY JOSEPH T. GOLABOWSKI - PHOTOGRAPHER - APRIL 10, 1934. VIEW FROM SOUTH-EAST - Presbyterian Church, West Cherry & North Mechanic Streets, Winchester, Scott County, IL
2. HISTORIC AMERICAN BUILDINGS SURVEY JOSEPH T. GOLABOWSKI PHOTOGRAPHER ...
2. HISTORIC AMERICAN BUILDINGS SURVEY JOSEPH T. GOLABOWSKI - PHOTOGRAPHER - APRIL 10, 1934. VIEW FROM NORTH-WEST - Presbyterian Church, West Cherry & North Mechanic Streets, Winchester, Scott County, IL
The Engine of Change: The Evolution of Culture into the Army Planning Process
2013-05-23
identify and then account for culture in its planning process.12 In essence, Napoleon Bonaparte , the Commander of the French Army, misunderstood the...Chandler, The Campaigns of Napoleon , 602. 17 Ibid. 8 Joseph Bonaparte , and prosecute...6 Vignette: Napoleon Bonaparte’s Lack of Cultural Consideration during the Peninsular Campaign, 1806–1814
Generational Ideas in Curriculum: A Historical Triangulation
ERIC Educational Resources Information Center
Hlebowitsh, Peter S.
2005-01-01
In this article, I examine the work of John Franklin Bobbitt, Ralph Tyler, and Joseph Schwab with the intention of identifying lines of continuity and change in the curriculum field. Most curriculum scholars cast this group of three in an analytical framework that puts Tyler in kinship with Bobbitt, and that puts Schwab, by virtue of his…
Using Data to Intensify Behavioral Interventions for Individual Students
ERIC Educational Resources Information Center
Kern, Lee; Wehby, Joseph H.
2014-01-01
In an earlier article (EJ1058920), Lee Kern and Joseph H. Wehby identified the reasons and process for using adaptive intensive behavioral intervention. Kern and Wehby use this article to present a fictional example of how the intervention is applied. Isaac, a 12 year old, 7th grade student at Highland Middle School, had a history of behavior…
The Workplace Know-How Skills Needed To Be Productive. Technical Report.
ERIC Educational Resources Information Center
Hollenbeck, Kevin
A study identified workplace know-how skills and characteristics that employers in Kalamazoo and St. Joseph counties in Michigan feel workers need to succeed and be productive. Employer input was obtained in fall 1993 at 12 focus group meetings during which a total of 103 of 192 invited local employers (a 53.6% attendance rate) completed…
Cummunicative Arts: A Selected Bibliography.
1998-06-01
Communication , 44- 75. New York: Harper Collins College Pub., 1993. 368pp. (P90 .D48 1993) DeVito, Joseph A. "Listening." In Human Communication : The...34Listening." In Human Communication , 140-63. 7th ed. New York: McGraw-Hill, 1994. 557pp. (P90 .T78 1994) Verbal Communication: The Power of Words. Rev. ed...D389 1994) DeVito, Joseph A. Essentials of Human Communication . New York: HarperCollins College Pub., 1993. 368pp. (P90 .D48 1993) DeVito, Joseph
1981-01-01
Headquarters U.S. Air Force; Mr. Joseph T. Kammerer, Director of Cost Estimating, Head- quarters Naval Material Command; and Dr. Michael Sovereign...different functional, but related responsibilities. l SIR I SECTION stimating in the 80s: 23 Panelist Presentation 11 Joseph T. Kammerer My...rates used in DOD are developed by the Office of the Secretary of Defense under the direction of the Office of Management and Budget (OMB). Joseph T
An Analysis of Meteorological Measurements Using a Miniature Quad-Rotor Unmanned Aerial System
2015-06-01
Christopher R. Machado Lieutenant, United States Navy B.S., University of Maryland, College Park, 2009 MEM , Old Dominion University, 2014 Submitted...recent years. BAE Systems’ Manta and Boeing’s Scan Eagle were tested in 2011 and 2012, demonstrating the first known UAS measurements of heat ... heats the atmosphere above it through turbulent fluxes and emitting radiation. The energy transfer between the earth’s surface and lower atmosphere is
PKC Epsilon: A Novel Oncogenic Player in Prostate Cancer
2014-09-01
cancer. Clin Cancer Res 15: 4799-4805. 3 Neto, A. S., Tobias-Machado, M., Wroclawski, M. L., Fonseca , F. L., Pompeo, A. C., Del Giglio, A. (2010...biological chemistry 268: 6090-6096. 19 Perletti, G. P., Folini, M., Lin, H. C., Mischak, H., Piccinini, F., Tashjian, A. H., Jr. ( 1996 ). Overexpression...7737. 36 Aparicio Gallego, G., Diaz Prado, S., Jimenez Fonseca , P., Garcia Campelo, R., Cassinello Espinosa, J., Anton Aparicio, L. M. (2007
4. HISTORIC AMERICAN BUILDINGS SURVEY JOSEPH T. GOLABOWSKI PHOTOGRAPHER ...
4. HISTORIC AMERICAN BUILDINGS SURVEY JOSEPH T. GOLABOWSKI - PHOTOGRAPHER - APRIL 10, 1934. COLUMN AND PIER DETAIL - LOOKING UP - Presbyterian Church, West Cherry & North Mechanic Streets, Winchester, Scott County, IL
77 FR 3773 - Ocean Transportation Intermediary License; Applicants
Federal Register 2010, 2011, 2012, 2013, 2014
2012-01-25
... McGee, Manager Member. Application Type: New NVO & OFF License. Joseph P. Solomon dba Equitorial Import-Export (OFF), 14810 Greenwood Avenue North, Shoreline, WA 98133. Officer: Joseph P. [[Page 3774
ASTRONAUT CONRAD, CHARLES - SKYLAB-II - JSC
1973-05-09
S73-25283 (8 May 1973) --- Astronaut Paul J. Weitz, prime crew pilot of the first manned Skylab mission, is suited up in Bldg. 5 at Johnson Space Center during prelaunch training activity. He is assisted by astronaut Charles Conrad Jr., prime crew commander. The man in the left background is wearing a face mask to insure that Conrad, Joseph Kerwin and Weitz are not exposed to disease prior to launch. Photo credit: NASA
19. Historic American Buildings Survey Joseph Hill, Photographer April 28, ...
19. Historic American Buildings Survey Joseph Hill, Photographer April 28, 1936 CORRIDOR SIDE OF CORRIDOR DOOR, TO OFFICE ON FIRST FLOOR - Old Knox County Courthouse, Main Street, Knoxville, Knox County, IL
1979-04-03
Zero-gravity experiments in KC-135 conducted by John Young, Robert L. Crippen, Joseph Kerwin, and Margaret Seddon. 1. Kerwin, Joseph - Zero-G 2. Seddon, Margaret - Zero-G 3. Young, John - Zero-G 4. Aircraft - KC-135
Federal Register 2010, 2011, 2012, 2013, 2014
2013-12-19
... contact Joseph Fox, Branch Chief, Alcohol and Tobacco Enforcement Branch, Bureau of Alcohol, Tobacco, Firearms and Explosives at Joseph.Fox@atf.gov . Written comments and suggestions from the public and...
Acoustical Emission Source Location in Thin Rods Through Wavelet Detail Crosscorrelation
1998-03-01
NAVAL POSTGRADUATE SCHOOL Monterey, California THESIS ACOUSTICAL EMISSION SOURCE LOCATION IN THIN RODS THROUGH WAVELET DETAIL CROSSCORRELATION...ACOUSTICAL EMISSION SOURCE LOCATION IN THIN RODS THROUGH WAVELET DETAIL CROSSCORRELATION 6. AUTHOR(S) Jerauld, Joseph G. 5. FUNDING NUMBERS Grant...frequency characteristics of Wavelet Analysis. Software implementation now enables the exploration of the Wavelet Transform to identify the time of
Reed, Robert; Todd, Brian D; Miano, Oliver J.; Canfield, Mark; Fisher, Robert N.; McMartin, Louanne
2016-01-01
Native to the southeastern United States, Southern Watersnakes (Nerodia fasciata) are known from two sites in California, but their ecological impacts are poorly understood. We investigated the ecology of Southern Watersnakes in Machado Lake, Harbor City, Los Angeles County, California, including an assessment of control opportunities. We captured 306 watersnakes as a result of aquatic trapping and hand captures. We captured snakes of all sizes (162–1063 mm snout–vent length [SVL], 3.5–873.3 g), demonstrating the existence of a well-established population. The smallest reproductive female was 490 mm SVL and females contained 12–46 postovulatory embryos (mean = 21). Small watersnakes largely consumed introduced Western Mosquitofish (Gambusia affinis), while larger snakes specialized on larval and metamorph American Bullfrogs (Lithobates catesbeianus) and Green Sunfish (Lepomis cyanellus). Overall capture per unit effort (CPUE) in traps declined with time during an intensive 76-d trapping bout, but CPUE trends varied considerably among traplines and it is unlikely that the overall decline in CPUE represented a major decrease in the snake population size. Although we found no direct evidence that Southern Watersnakes are affecting native species in Machado Lake, this population may serve as a source for intentional or unintentional transportation of watersnakes to bodies of water containing imperiled native prey species or potential competitors.
20. Photocopy of photograph (from Joseph R. Knowland Collection, Oakland, ...
20. Photocopy of photograph (from Joseph R. Knowland Collection, Oakland, California, c. 1902) EXTERIOR, DETAIL OF BELFRY & CONVENTO, OVERGROWN CONDITIONS, C. 1902 - Mission San Francisco Solano de Sonoma, First & Spain Streets, Sonoma, Sonoma County, CA
1. Historic American Buildings Survey Joseph Hill, Photographer October 1936 ...
1. Historic American Buildings Survey Joseph Hill, Photographer October 1936 #12 EARLY RED BRICK HOUSE, Elk and Prospect Sts., Galena, Illinois - Galena Doorways, Red Brick House, Elk & Prospect Streets, Galena, Jo Daviess County, IL
12. Historic American Buildings Survey Joseph Hill, Photographer July 10, ...
12. Historic American Buildings Survey Joseph Hill, Photographer July 10, 1936 SOUTH ELEVATION (Copied from student's drawing, Dept. of Architecture, Armour Institute of Technology. Chicago) - Keating House, U.S. Highway 430, Fayville, Alexander County, IL
Gadomski, Dena M.; Venditti, David A.; Robinson, T. Craig; Beeman, John W.; Maule, Alec G.
2004-01-01
We surveyed fish assemblages in littoral areas of Chief Joseph Reservoir of the upper Columbia River to aid in understanding this ecosystem. Fish distributions and abundances were examined during April-July 1999 in relation to environmental conditions in the reservoir. We also compared the fish assemblages in Chief Joseph reservoir in 1999 to a past study conducted during 1974-1975, and to assemblages in other areas of the Columbia River. During 67 hr of electrofishing and 78 beach seine hauls in Chief Joseph Reservoir, 7460 fishes representing 8 families were collected. The majority of the catch was native – northern pikeminnow; redside shiners; longnose, bridgelip, and largescale suckers; and sculpins. The most abundant introduced species was walleye, and one species, rainbow trout, was mostly of net-pen origin. Larger sizes of suckers and northern pikeminnow were most abundant in the upper reservoir, likely due to upstream spawning migrations. The lower reservoir contained greater abundances of smaller fishes, and this area had lower flows, smaller substrates, and more complex shorelines that offered these fishes refugia. Only adult suckers displayed significant differences in abundances related to substrate. The relative abundances of species appeared to have changed since the 1970s, when the dominant fishes were northern pikeminnow, peamouth, largescale suckers, and walleye. Fish assemblage differences between Chief Joseph Reservoir and lower Columbia River reservoirs were also evident due to the morphology of the reservoir, its more northerly location, and the lack of fish passage facilities at Chief Joseph Dam. Our study is one of the few descriptions of fishes in the upper Columbia Rivers.
Skylab 2 prime crew suit up during prelaunch training activity
1973-05-08
S73-25399 (8 May 1973) --- Astronaut Paul J. Weitz, prime crew pilot of the first manned Skylab mission, is suited up in Bldg. 5 at Johnson Space Center (JSC) during prelaunch training activity. He is assisted by astronaut Charles Conrad, Jr., prime crew commander. The man in the left background is wearing a face mask to insure that Conrad, Joseph Kerwin and Weitz are not exposed to disease prior to launch. Photo credit: NASA
Multi-modal Biomarkers to Discriminate Cognitive State
2015-11-01
in the speech of a large sample of Parkinson patients. J. Speech Hear. Disord. 43(1), 47. 36. Ekman, P., Freisen, W.V. and Ancoli, S . 1980. Facial...Patel, Laura Brattain, Brian S . Helfer, Daryush D. Mehta, Jeffrey Palmer Kristin Heaton2, Marianna Eddy3, Joseph Moran3 1MIT Lincoln Laboratory...Parkinson’s disease [23]-[35]. Voice has been used in cognitive load by Yin et al [2] who achieved 77% accuracy using standard vocal features (e.g., mel
NASA Astrophysics Data System (ADS)
Sterken, C.
2003-03-01
This paper gives a short account of some key elements in the life of Jean Baptiste Joseph Fourier (1768-1830), specifically his relation to Napoleon Bonaparte. The mathematical approach to Fourier series and the original scepticism by French mathematicians are briefly illustrated.
18. Historic American Buildings Survey Joseph Hill, Photographer May 26, ...
18. Historic American Buildings Survey Joseph Hill, Photographer May 26, 1936 FIREPLACE IN DINING ROOM, The Davenport House, Rock Island Arsenal - Rock Island Arsenal, Building No. 346, Davenport Drive, Arsenal Grounds, Rock Island, Rock Island County, IL
Archaeological Investigations at Sites 45-OK-250 and 45-OK-4, Chief Joseph Dam Project, Washington.
1984-01-01
level behind Chief Joseph Dam. Systematic random sampling using I x I x ’ - 0.1-m collection units in 1 x 1, 1 x 2, or 2 x 2 m cel Is disclosed...ft to the operating pool . level behind Chief Joseph Dam. Systematic random sampling using 1 x 1 x 0.1-i collection units In 1 x 1, 1 x 2, or 2 x 2 m...contingencies under which data were collected , describe data collection and analysis, and organize and summarize data In a torm useful to the widest
Strategy Handbook for Recreational Small Boat Harbor Financing,
1988-01-01
County Planning & North Point Marina Zoning Committee State of Illinois Sonoma County . CA o William A. Jansen, P.E., Proj. Dir. o Joseph D. Rodota...Director North Point Marina Sonoma County Regional Parks Office of Planning & Development o Ernie Carpenter, Chairman Dept. of Conservation Sonoma ...Spud Point Marina, Sonoma County , California; and Miami Beach Marina, Miami Beach, Florida. Findings from these studies were used to identify
Ultrastructure Processing and Characterization of Polymers
1988-01-01
Eur. Polym. J . 24, 123-127 (1988) (with R. Vukovic , G. Bogdanic, V. Kuresevic, and W.J. MacKnight) "Miscibility and Phase Behavior in Poly (2,6...Month, Day) |I5 fAGE U d FINAL FROM TO j -"_ 16. SUPPLEMENTARY NOTATION 17. COSATI CODES 18. SUBJECT TERMS (Continue on reverse if necessary and...Lee Dr. J . Obrzut Dr. D. Rice Dr. J . Schlenoff Dr. J . Shim V. JUNIOR RESEARCH PERSONNEL: M. Bishop R. Gregorius M. Lux J . Machado M. Masse R
BRASS MILL #72 SLITTER, OPERATED BY JOSEPH WAGNER, FORMERLY AN ...
BRASS MILL #72 SLITTER, OPERATED BY JOSEPH WAGNER, FORMERLY AN EMPLOYEE OF REPUBLIC STEEL IN BUFFALO. BRASS STRIP FROM THE SLITTE IS USED ON THE BUFFALO PLANT'S CONTINUOUS SEAMLESS TUBE LINE. - American Brass Foundry, 70 Sayre Street, Buffalo, Erie County, NY
Video from Panel Discussion with Joseph Fraumeni and David Schottenfeld
Video footage from Panel Discussion with Joseph Fraumeni and David Schottenfeld on Cancer Epidemiology over the Last Half-Century and Thoughts on the Future. The discussion took place on May 11, 2012, when DCEG hosted Dr. Schottenfeld as a Visiting Scholar.
16. A LONGER VIEW OF THE SAME LAMP STANDARD, SHOWING ...
16. A LONGER VIEW OF THE SAME LAMP STANDARD, SHOWING THE OCTAGONAL PEBBLE AGGREGATE SHAFT. - County Line Bridge, Spanning St. Joseph River at State Route 219, 0.6 mile south of U.S. Route 20, Osceola, St. Joseph County, IN
7. Detail view north of stone wall and wood gate ...
7. Detail view north of stone wall and wood gate between Ten Acre Lot (foreground) and Barn Meadow (background) with Joseph Fry Farm complex beyond - Joseph Fry Farm Landscape, 2153 South County Trail Road (U.S. Route 2), East Greenwich, Kent County, RI
4. Detail view north of stone wall opening between Five ...
4. Detail view north of stone wall opening between Five Acre Lot (foreground) and Ten Acre Lot (background) with Joseph Fry Farm complex beyond - Joseph Fry Farm Landscape, 2153 South County Trail Road (U.S. Route 2), East Greenwich, Kent County, RI
6. AN IMAGE LOOKING NORTH ALONG THE BRIDGE SIDEWALK, SHOWING ...
6. AN IMAGE LOOKING NORTH ALONG THE BRIDGE SIDEWALK, SHOWING THE CONCRETE BALUSTRADES, LAMP STANDARDS AND ASPHALT ROADWAY. - County Line Bridge, Spanning St. Joseph River at State Route 219, 0.6 mile south of U.S. Route 20, Osceola, St. Joseph County, IN
An Interview with Joseph Chilton Pearce.
ERIC Educational Resources Information Center
Luvmour, Josette; Luvmour, Ba; Dupler-King, Kathy; Pearce, Joseph Chilton
1999-01-01
Author Joseph Chilton discusses parents' roles in child rearing, the importance of nurturing, and how negative and positive childhood experiences affect one's emotional and physical health throughout life. Describes neurocardiology, which is documenting the biological connections between the brain and heart and lifting the wisdom and intelligence…
Joseph v. Brady: Synthesis Reunites What Analysis Has Divided
ERIC Educational Resources Information Center
Thompson, Travis
2012-01-01
Joseph V. Brady (1922-2011) created behavior-analytic neuroscience and the analytic framework for understanding how the external and internal neurobiological environments and mechanisms interact. Brady's approach offered synthesis as well as analysis. He embraced Findley's approach to constructing multioperant behavioral repertoires that found…
Closing the Convoy Security Gap
2013-04-11
January 18, 2013. Heiser Jr., LtGen Joseph M. Vietnam Studies: Logistic Support. Washington, DC: Department of the Army, 1991. Killbane, Richard E...School Library, 1968. http://www.transchool.eustis.army.mil/lic/documents/pdf/bellino.pdf 13 LtGen Joseph M. Heiser Jr., Vietnam Studies: Logistic
2. Historic American Buildings Survey Joseph Hill, Photographer October 28, ...
2. Historic American Buildings Survey Joseph Hill, Photographer October 28, 1936 #1 DOORWAY MAXIENER HOUSE 104 South Bench Street, Galena, Ill. (Said to be oldest frame house in Galena) - Galena Doorways, Elizabeth Maxiener Cottage, 104 South Bench Street, Galena, Jo Daviess County, IL
76 FR 25763 - Qualification of Drivers; Exemption Applications; Vision
Federal Register 2010, 2011, 2012, 2013, 2014
2011-05-05
... Pulido, Oliver Murphy, Jerome Smalls, Alan Jenkins, Ryan Forsythe, Terry L. Randoll, Edward Joseph... for an exemption. Thomas L. Newingham, Joseph Barlow. The following 2 applicants do not have.... Royce Thomas, Randy Fielder. The following 4 applicants were denied for miscellaneous/multiple reasons...
Teaching Invisible Culture: Classroom Practice and Theory.
ERIC Educational Resources Information Center
Lo Bianco, Joseph, Ed.; Crozet, Chantal, Ed.
This collection of papers discusses what researchers and classroom teachers think and do about culture in language education. There are nine chapters in two parts. Part 1, "Culture Theory," includes the following: (1) "Common Themes" (Joseph Lo Bianco); (2) "Culture: Visible, Invisible and Multiple" (Joseph Lo…
Using Joseph Campbell to Improve Students' Response to Literature.
ERIC Educational Resources Information Center
Barnum, Carol M.
1992-01-01
Shows how teachers can use the videotapes and writings of Joseph Campbell to help students see patterns in literature and respond personally to it. Presents Campbell's explanation of the monomyth of the hero's journey, and discusses three works in which the pattern is present. (SR)
Content, Joseph Schwab and German "Didaktik"
ERIC Educational Resources Information Center
Deng, Zongyi
2015-01-01
This article attempts to extend and deepen the conversation concerning the knowledge-based approach to curriculum espoused by Michael Young in his 2013 "JCS" paper through revisiting the structure of the disciplines thinking of Joseph Schwab and German "Didaktik." It argues that curriculum making requires a theory of knowledge…
9. IMAGE OF THE EAST ELEVATION OF THE BRIDGE SHOWING ...
9. IMAGE OF THE EAST ELEVATION OF THE BRIDGE SHOWING THE CONCRETE OPEN SPANDRELS, MISSING BALUSTRADES AND THE LAMP STANDARDS. - County Line Bridge, Spanning St. Joseph River at State Route 219, 0.6 mile south of U.S. Route 20, Osceola, St. Joseph County, IN
Logistics in Security Force Assistance: Sustainable Partner Development
2014-05-22
93Khuyen, 446. 94See Lieutenant General Joseph M. Heiser , Jr., CMH Pub 90-15, Logistic Support (Washington, DC: Center of Military History, U.S. Army...Government Printing Office, 2009. Heiser , Joseph M. Jr., Lieutenant General. CMH Pub 90-15, Logistic Support. Washington, DC: Center of Military
Mission Specific Embedded Training Using Mixed Reality
2011-10-01
3] Mark A. Livingston, J. Edward Swan II, Simon J. Julier, Yohan Baillot, Dennis G. Brown, Lawrence J. Rosenblum, Joseph L. Gabbard , Tobias H...Mark A. Livingston, Lawrence J. Rosenblum, Simon J. Julier, Dennis Brown, Yohan Baillot, Edward Swan, Joseph L. Gabbard , and Deb- orah Hix. An Augmented
Draguta, Sergiu; Sharia, Onise; Yoon, Seog Joon; Brennan, Michael C; Morozov, Yurii V; Manser, Joseph S; Kamat, Prashant V; Schneider, William F; Kuno, Masaru
2018-01-11
The original version of this Article contained an error in the spelling of the author Joseph S. Manser, which was incorrectly given as Joseph M. Manser. This has now been corrected in both the PDF and HTML versions of the Article.
Post Cold War Nuclear Weapons Policy
2012-03-20
are unknown.”14 This instability threatens the success and future of the NPT. According to scholar Joseph F. Pilat , While the vision of a nuclear...for the Study of Weapons of Mass Destruction, April 2007. 15 Joseph F. Pilat , “Nonproliferation, Arms Control and Disarmament, and ExtendedDeterrence
Federal Register 2010, 2011, 2012, 2013, 2014
2011-01-26
..., Fenton, Joplin, Lee's Summit, Pleasant Valley, Poplar Bluff, Rolla, Springfield, St. Joseph, St. Peters... in Missouri: Cameron, Cape Girardeau, Columbia, Farmington, Fenton, Joplin, Lee's Summit, Pleasant..., Farmington, Fenton, Joplin, Lee's Summit, Pleasant Valley, Poplar Bluff, Rolla, Springfield, St. Joseph, St...
Molecular Studies of HTLV-1 Infection in Newly Recognized High Risk Population
1993-07-10
showing similar sequence to African Isolates. 14. SUBJECT TERMS 15. NUMBER OF PAGES HTLV-I, Epidemiology , Polymerase, Virus, Aids, Biotechnology, RAD... Epidemiologic and molecular studies of both viruses have identified several themes underlying the leukemogenic process. Leukemia is a rare consequence...form. Key words EPIDEMIOLOGIC AND MOLECULAR CIARACTERIZATION 1st OF HTLV-I INFEXTION IN ISRAEL SYehuda L. Danon, el Kilim, and Joseph Rosenblatt
Evolving Regional Security in the Andean Region
2004-03-19
November 2003. 5 Joseph R. Nuñez, “Luchando en Contra de la Trinidad Hobbesiana en Colombia: Una Estrategia Para la Paz” Aerospace Power Journal . Tercer...December 2002. Nuñez, Joseph R. Luchando en Contra de la Trinidad Obesiana en Colombia: Una Estrategia Para la Paz. Aerospace Power Journal. Tercer
76 FR 12962 - Ocean Transportation Intermediary License Applicants
Federal Register 2010, 2011, 2012, 2013, 2014
2011-03-09
...), 17910 Ajax Circle, City of Industry, CA 91748. Officers: Jacky C. Chen, President (Qualifying Individual... Change. J.A. Logistics, Inc. (NVO & OFF), 3905 West Albany Street, McHenry, IL 60050. Officers: Joseph M... Harbour Road, Wanchai, Hong Kong. Officers: Tsang M. Tak, Director/CEO (Qualifying Individual), Joseph P...
1. View north from StanleyBostitch property toward southern boundary/stone wall ...
1. View north from Stanley-Bostitch property toward southern boundary/stone wall of Joseph Fry Farm with South County Trail/Route 2 to the east (right) - Joseph Fry Farm Landscape, 2153 South County Trail Road (U.S. Route 2), East Greenwich, Kent County, RI
Being Creative "Inside the Box"
ERIC Educational Resources Information Center
Tomascoff, Rocky
2011-01-01
Artist Joseph Cornell (1903-1972) created wonderful environments inside boxes using mostly found objects. They were often Surrealistic in nature. Some boxes were designed with glass fronts, and others were meant to be interactive with the viewer, wherein the objects could be handled. With Joseph Cornell in mind, the author introduces an art…
30 CFR Appendix to Part 253 - List of U.S. Geological Survey Topographic Maps
Code of Federal Regulations, 2010 CFR
2010-07-01
.... Florida (1:24,000 scale): Allanton; Alligator Bay; Anna Maria; Apalachicola; Aripeka; Bayport; Beacon...; Miramar Beach; Myakka River; Naples North; Naples South; Navarre; New Inlet; Niceville; Nutall Rise... Level; Rock Islands; Royal Palm Hammock; Safety Harbor; Saint Joseph Point; Saint Joseph Spit; Saint...
Joseph Priestley Is the Focus as Modern Chemistry Celebrates Its Second Century
ERIC Educational Resources Information Center
Bernheim, Robert A.; Olofson, Roy A.
1974-01-01
This article describes a meeting in 1874, seen to be the origin of the American Chemical Society, which commemorated the 100th anniversary of Joseph Priestley's discovery of oxygen. The remainder of the article is concerned with Priestley's scientific contributions and their implications. (DT)
15. A CLOSE UP VIEW OF ONE OF THE EXPOSED ...
15. A CLOSE UP VIEW OF ONE OF THE EXPOSED AGGREGATE LAMP STANDARDS, ITS BRONZE DECORATED FERRULE AND BRONZE LENS RECEIVER. - County Line Bridge, Spanning St. Joseph River at State Route 219, 0.6 mile south of U.S. Route 20, Osceola, St. Joseph County, IN
Federal Register 2010, 2011, 2012, 2013, 2014
2012-05-01
... 2400 St. Joseph Street in Overton, Nevada, with an open house at the same location. This hearing will... School on 2400 St. Joseph Street in Overton, Nevada from 6:30 p.m. to 8:30 p.m. on May 3, 2012, with an...
Federal Register 2010, 2011, 2012, 2013, 2014
2013-09-26
... Northern California District manager, (530) 224-2160; or Joseph J. Fontana, BLM public affairs officer... as provided above. Dated: September 10, 2013. Joseph J. Fontana, Public Affairs Officer. [FR Doc... Public Meeting: Northeast California Resource Advisory Council Sage Grouse Conservation Subcommittee and...
77 FR 67664 - Notice of Public Meeting Cancellation: Northwest California Resource Advisory Council
Federal Register 2010, 2011, 2012, 2013, 2014
2012-11-13
..., BLM Northern California District manager, (530) 221-1743; or Joseph J. Fontana, public affairs officer..., 2012. Joseph J. Fontana, Public Affairs Officer. [FR Doc. 2012-27523 Filed 11-9-12; 8:45 am] BILLING... Public Meeting Cancellation: Northwest California Resource Advisory Council AGENCY: Bureau of Land...
75 FR 10818 - Notice of Resource Advisory Council Vacancies
Federal Register 2010, 2011, 2012, 2013, 2014
2010-03-09
... forms are available by contacting BLM Public Affairs Officer Joseph J. Fontana, 2950 Riverside Drive..., California 96130, Attention: Public Affairs Officer, no later than April 8, 2010. Individuals can nominate...-1743, or Public Affairs Officer Joseph J. Fontana at the above phone or e-mail address. Authority: 43...
ASK Talks With Joseph Rothenberg
NASA Technical Reports Server (NTRS)
Rothenberg, Joseph
2002-01-01
Recently retired NASA administrator Joseph Rothenberg reflects on project management during the Apollo era at the start of his career, as well as the history of, and changes in, project management over his years at NASA. He concludes by describing what he sees as NASA's most important needs in the near future.
Cells Team Lead Joe.Berry@nrel.gov | 303-384-7611 Joseph Berry is a senior research scientist at NREL Department of Physics at the University of Colorado at Boulder. Research Interests His interest in transport theme of his work throughout his scientific carrier. These interests in fundamental aspects of
75 FR 32742 - Action Affecting Export Privileges; Joseph Piquet
Federal Register 2010, 2011, 2012, 2013, 2014
2010-06-09
... DEPARTMENT OF COMMERCE Bureau of Industry and Security Action Affecting Export Privileges; Joseph... on behalf of the Denied Person any item subject to the Regulations; B. Take any action that... or attempts to acquire such ownership, possession or control; C. Take any action to acquire from or...
Ali, Joseph; Labrique, Alain B; Gionfriddo, Kara; Pariyo, George; Gibson, Dustin G; Pratt, Bridget; Deutsch-Feldman, Molly; Hyder, Adnan A
2017-05-05
Mobile phone coverage has grown, particularly within low- and middle-income countries (LMICs), presenting an opportunity to augment routine health surveillance programs. Several LMICs and global health partners are seeking opportunities to launch basic mobile phone-based surveys of noncommunicable diseases (NCDs). The increasing use of such technology in LMICs brings forth a cluster of ethical challenges; however, much of the existing literature regarding the ethics of mobile or digital health focuses on the use of technologies in high-income countries and does not consider directly the specific ethical issues associated with the conduct of mobile phone surveys (MPS) for NCD risk factor surveillance in LMICs. In this paper, we explore conceptually several of the central ethics issues in this domain, which mainly track the three phases of the MPS process: predata collection, during data collection, and postdata collection. These include identifying the nature of the activity; stakeholder engagement; appropriate design; anticipating and managing potential harms and benefits; consent; reaching intended respondents; data ownership, access and use; and ensuring LMIC sustainability. We call for future work to develop an ethics framework and guidance for the use of mobile phones for disease surveillance globally. ©Joseph Ali, Alain B Labrique, Kara Gionfriddo, George Pariyo, Dustin G Gibson, Bridget Pratt, Molly Deutsch-Feldman, Adnan A Hyder. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 05.05.2017.
Legendre, Claire-Marie; Charpentier-Côté, Catherine; Drouin, Régen; Bouffard, Chantal
2011-02-09
In 1986, two Canadian geneticists had demonstrated that Joseph Merrick, better known as the Elephant Man, suffered from the Proteus syndrome and not from neurofibromatosis type 1 (NF1), as was alleged by dermatologist Parkes in 1909. Despite this and although the two diseases differ at several levels: prevalence, diagnostic criteria, clinical manifestations and transmission, the confusion between NF1 and the "elephant man's" disease continues in medical and social representations by current linguistic usage, and in some media reports. With this article, we want to 1) document the persistence and extent of this fallacy, 2) identify certain critical factors that contribute to its persistence, and 3) evaluate its impact on the health and well being of patients with NF1 and their family members. Participant observation in the course of an ethnographic study on intergenerational dialogue between individuals with neurofibromatosis and their parents - Analysis of the scientific literature and of pinpoint articles in the print and online news media. Our findings show that because physicians have little knowledge about NF1, several print and online news media and a lot of physicians continue to make the confusion between NF1 and the disease the "elephant man". This misconception contributes to misinformation about the disease, feeding prejudices against affected patients, exacerbating the negative impacts of the disease on their quality of life, their cognitive development, their reproductive choices, as well as depriving them of proper care and appropriate genetic counseling. If family physicians and pediatricians were properly informed about the disease, they could refer their patients with NF1 to NF clinics and to specialists. Thus, patients and their family members would benefit from better-tailored clinical management of their cases, perhaps even optimal management. [corrected
Science and Worldviews in the Classroom: Joseph Priestley and Photosynthesis
ERIC Educational Resources Information Center
Matthews, Michael R.
2009-01-01
This paper elaborates on the life and publications of Joseph Priestley, the eighteenth-century polymath. The paper outlines his particular place in the European Enlightenment; it stresses the importance of philosophy and worldview in his scientific work on pneumatic chemistry, the composition of air, and his discovery of the process of…
Astronaut Joseph Tanner checks gloves during during launch/entry training
NASA Technical Reports Server (NTRS)
1994-01-01
Astronaut Joseph R. Tanner, mission specialist, checks his gloves during a rehearsal for the launch and entry phases of the scheduled November 1994 flight of STS-66. This rehearsal, held in the crew compartment trainer (CCT) of JSC's Shuttle mockup and integration laboratory, was followed by a training session on emergency egress procedures.
Riotous Images: Representations of Joseph Priestley in British Prints during the French Revolution
ERIC Educational Resources Information Center
Clay, Richard
2008-01-01
This article focuses on printed images that were published in Britain during the 1790s, depicting the educationist, theologian, chemist, physicist, historian and philosopher Joseph Priestley (1733-1804). It is argued that such etchings and engravings are indicative of, and contributed to, the lifelong political and historical education of late…
Joseph Rotblat: Influences, Scientific Achievements and Legacy
ERIC Educational Resources Information Center
Underwood, Martin
2008-01-01
Joseph Rotblat was one of the most distinguished nuclear physicists and peace campaigners of the post Second World War period. His peace activities rank alongside those of Albert Einstein and Bertrand Russell; he won the Nobel Peace Prize, jointly with the Pugwash movement, that he helped found. However, he made significant contributions to…
Federal Register 2010, 2011, 2012, 2013, 2014
2012-03-09
... NUCLEAR REGULATORY COMMISSION [Docket Nos. 50-348 AND 50-364; NRC-2012-0053] Facility Operating License Amendment From Southern Nuclear Operating, Inc., Joseph M. Farley Nuclear Plant, Units 1 and 2...-0053. You may submit comments by the following methods: Federal Rulemaking Web site: Go to http://www...
[Pierre-Joseph-Cécilien Simonart (1816-1847) and the problem of amniotic bands].
Louryan, S
2013-01-01
Pierre-Joseph-Cécilien Simonart (1816-1847) was an obstetrician and an anatomist in the Université libre de Bruxelles. He described and analyzed the "amniotic bands" and their effects on the fetus. In this contribution, we situate his work in the evolution of the knowledge relative to this pathology.
76 FR 30965 - Notice of Public Meeting: Northwest California Resource Advisory Council
Federal Register 2010, 2011, 2012, 2013, 2014
2011-05-27
... California District manager, (530) 221-1743; or Joseph J. Fontana, public affairs officer, (530) 252-5332.... Joseph J. Fontana, Public Affairs Officer. [FR Doc. 2011-13233 Filed 5-26-11; 8:45 am] BILLING CODE 4310... Public Meeting: Northwest California Resource Advisory Council AGENCY: Bureau of Land Management...
Pioneer in Behavioral Pharmacology: A Tribute to Joseph V. Brady
ERIC Educational Resources Information Center
Barrett, James E.
2008-01-01
The contributions of Joseph V. Brady to behavioral pharmacology span more than 50 years and range from early studies using the Estes-Skinner ("conditioned emotional response") procedure to examine drug effects and various physiological processes in experimental animals to the implementation of mobile methadone treatment services and to small group…
Pilates and Mindfulness: A Qualitative Study
ERIC Educational Resources Information Center
Adams, Marianne; Caldwell, Karen; Atkins, Laurie; Quin, Rebecca
2012-01-01
The Pilates method as Joseph Hubertus Pilates originally defined it in the early 1920s, was called "Contrology," or the art of control, based on the ideal of attaining a complete coordination of body, mind, and spirit. Joseph Pilates's early writings emphasized the value of controlling the body rather than attending to the process of body…
75 FR 5112 - Notice of Public Meeting: Northwest California Resource Advisory Council
Federal Register 2010, 2011, 2012, 2013, 2014
2010-02-01
... Public Affairs Officer Joseph J. Fontana, (530) 252-5332. SUPPLEMENTARY INFORMATION: The 12-member... include discussion of BLM image and identity issues, a status report on public land equestrian projects in..., 2010. Joseph J. Fontana, Public Affairs Officer. [FR Doc. 2010-2003 Filed 1-29-10; 8:45 am] BILLING...
76 FR 71374 - Joseph Giacchino, M.D.; Decision and Order
Federal Register 2010, 2011, 2012, 2013, 2014
2011-11-17
... DEPARTMENT OF JUSTICE Drug Enforcement Administration [Docket No. 10-54] Joseph Giacchino, M.D.; Decision and Order On July 9, 2010, Administrative Law Judge (ALJ) Timothy D. Wing, issued the attached... prevail. See, e.g., Bourne Pharmacy, 72 FR 18,273, 18,274 (2007); Agostino Carlucci, M.D., 49 FR 33,184...
Perspectives on Ethnicity in New Orleans.
ERIC Educational Resources Information Center
Cooke, John, Ed.
This pamphlet contains several essays on the culture and ethnic groups of New Orleans, Louisiana. Included are: (11 a discussion by Joseph Logsdon on the uniqueness of New Orleans culture, marked by its cuisine, interethnic mixtures, and its politics; (2) an article on theories of ethnicity and neo ethnicity, by Joseph V. Guillotte, III; (3) a…
Nature, Nurture, and Attention Deficit Hyperactivity Disorder.
ERIC Educational Resources Information Center
Faraone, Stephen V.; Biederman, Joseph
2000-01-01
Comments on Joseph's review of the genetics of attention deficit disorder, demonstrating errors of scientific logic and oversight of relevant research in Joseph's argument. Argues for the validity of twin studies in supporting a genetic link for ADHD and for the complementary role of nature and nurture in the etiology of the disorder. (JPB)
Suicide of a close family member through the eyes of a child: A narrative case study report.
Jackson, Debra; Peters, Kath; Murphy, Gillian
2015-12-01
A narrative case study approach was used to collect a storied account from Joseph about his recollections and experience of the completed suicide of a family member with whom he lived with at 13 years of age. Data are presented longitudinally to capture Joseph's perceptions and recollections of events leading up to, surrounding and following the suicide. Findings reveal that, as a child Joseph felt strong responsibility to keep his uncle safe and maintain his uncle's life; and perceived a lack of support for himself and his family throughout the events. Today as a young man, Joseph remains profoundly affected by this suicide and the events surrounding it, and experiences flashbacks and intrusive thoughts, though his distress remains largely invisible to others. It is important that the acute and longer term needs of children affected by suicidality and suicide are recognised. We argue that increased awareness on the part of health professionals about the ongoing grief and distress surrounding suicide survivorship can create opportunities for opportunistic assessment and review of child survivor welfare. © The Author(s) 2013.
Programming Retinal Stem Cells into Cone Photoreceptors
2015-12-01
AWARD NUMBER: W81XWH-14-1-0566 TITLE: Programming Retinal Stem Cells into Cone Photoreceptors PRINCIPAL INVESTIGATOR: Joseph A. Brzezinski IV...SUBTITLE 5a. CONTRACT NUMBER Programming Retinal Stem Cells into Cone Photoreceptors 5b. GRANT NUMBER W81XWH-14-1-0566 5c. PROGRAM ELEMENT NUMBER 6...to program human stem cells directly into cones. Using RNA-seq, we identified several genes that are upregulated in advance of the earliest
Oral Contraceptives Use by Young Woman Reduces Peak Bone Mass
1999-09-01
Alphacel 10.0 Lard 5.20 Safflower Oil (linoleic) 1.00 Choline Bitartrate 0.20 Vitamin Mixture, AIN-76A 1.00 Mineral Mix, AIN-76 3.50 On Nov...774-9,1970 Modrowoski D, del Pozo E, Miravet L . Horm Metab Res 24(10):474-477, 1992. Parfitt AM, Drezner MK, Glorieux FH, et al. J Bone Mineral Res...Register.1 C. L . Hughes.*2 U. Blas- Machado.*1 E. Sulistiawati.*’ P. W. Louderback.*1 S. E. Rankin.*1 ’Pathology/Comparative Medicine, Wake Forest
Belykh, Evgenii; Malik, Kashif; Simoneau, Isabelle; Yagmurlu, Kaan; Lei, Ting; Cavalcanti, Daniel D; Byvaltsev, Vadim A; Theodore, Nicholas; Preul, Mark C
2016-07-01
André Feil (1884-1955) was a French physician best recognized for his description, coauthored with Maurice Klippel, of patients with congenital fusion of cervical vertebrae, a condition currently known as Klippel-Feil syndrome. However, little is known about his background aside from the fact that he was a student of Klippel and a physician who took a keen interest in describing congenital anomalies. Despite the relative lack of information on Feil, his contributions to the fields of spinal disease and teratology extended far beyond science to play an integral role in changing the misguided perception shrouding patients with disfigurements, defects, deformities, and so-called monstrous births. In particular, Feil's 1919 medical school thesis on cervical abnormalities was a critical publication in defying long-held theory and opinion that human "monstrosities," anomalies, developmental abnormalities, and altered congenital physicality were a consequence of sinful behavior or a reversion to a primitive state. Indeed, his thesis on a spinal deformity centering on his patient, L. Joseph, was at the vanguard for a new view of a patient as nothing less than fully human, no matter his or her physicality or appearance.
Kincare, K.A.
2007-01-01
The water level of the Lake Michigan basin is currently 177 m above sea level. Around 9,800 14C years B.P., the lake level in the Lake Michigan basin had dropped to its lowest level in prehistory, about 70 m above sea level. This low level (Lake Chippewa) had profound effects on the rivers flowing directly into the basin. Recent studies of the St. Joseph River indicate that the extreme low lake level rejuvenated the river, causing massive incision of up to 43 m in a valley no more than 1.6 km wide. The incision is seen 25 km upstream of the present shoreline. As lake level rose from the Chippewa low, the St. Joseph River lost competence and its estuary migrated back upstream. Floodplain and channel sediments partially refilled the recently excavated valley leaving a distinctly non-classical morphology of steep sides with a broad, flat bottom. The valley walls of the lower St. Joseph River are 12-18 m tall and borings reveal up to 30 m of infill sediment below the modern floodplain. About 3 ?? 108 m3 of sediment was removed from the St. Joseph River valley during the Chippewa phase lowstand, a massive volume, some of which likely resides in a lowstand delta approximately 30 km off-shore in Lake Michigan. The active floodplain below Niles, Michigan, is inset into an upper terrace and delta graded to the Calumet level (189 m) of Lake Chicago. In the lower portion of the terrace stratigraphy a 1.5-2.0 m thick section of clast-supported gravel marks the entry of the main St. Joseph River drainage above South Bend, Indiana, into the Lake Michigan basin. This gravel layer represents the consolidation of drainage that probably occurred during final melting out of ice-marginal kettle chains allowing stream piracy to proceed between Niles and South Bend. It is unlikely that the St. Joseph River is palimpsest upon a bedrock valley. The landform it cuts across is a glaciofluvial-deltaic feature rather than a classic unsorted moraine that would drape over pre-glacial topography. ?? 2006 Springer Science+Business Media B.V.
Psi Chi/APA Edwin B. Newman Graduate Research Award: Joseph H. Hammer
ERIC Educational Resources Information Center
American Psychologist, 2009
2009-01-01
Joseph H. Hammer, recipient of the Psi Chi/APA Edwin B. Newman Graduate Research Award, is cited for an outstanding research paper whose findings provide important evidence regarding the promise of a male-sensitive approach to mental health marketing and empirically support the inclusion of theory-driven enhancements in group-targeted mental…
The Oral History of Evaluation: The Professional Development of Joseph Wholey
ERIC Educational Resources Information Center
Miller, Robin Lin; Caracelli, Valerie
2013-01-01
Joseph S. Wholey is Professor Emeritus in the University of Southern California's (USC) School of Public Policy, Planning, and Development. He received his BA from Catholic University, Phi Beta Kappa and his MA in mathematics and PhD in philosophy from Harvard University. His work focuses on the use of strategic planning, performance measurement,…
Inside and outside: Boxes Inspired by Joseph Cornell
ERIC Educational Resources Information Center
Winters, Laurel
2009-01-01
In this article, the author describes an art project inspired by the work of Joseph Cornell. The project called for designing both the outside and the inside of a cigar box according to the student's theme. Thus, students needed to consider the viewer's vantage point with the box both closed and open, general design elements, two-dimensional and…
ERIC Educational Resources Information Center
Debnath, Lokenath
2012-01-01
This article deals with a brief biographical sketch of Joseph Fourier, his first celebrated work on analytical theory of heat, his first great discovery of Fourier series and Fourier transforms. Included is a historical development of Fourier series and Fourier transforms with their properties, importance and applications. Special emphasis is made…
The Joseph Bellamy House: Great Awakening in Puritan New England. Teaching with Historic Places.
ERIC Educational Resources Information Center
Pape, Barbara Bradbury
The small rural town of Bethlehem, Connecticut, contains pristine examples of modest 18th-century houses that surround a charming village green. Opposite the village green, the Reverend Joseph Bellamy's immense white clapboard house rises from a hilltop, an imposing presence that makes the village appear diminutive. The house stands today as a…
ERIC Educational Resources Information Center
Mullen, Carol A.
2006-01-01
This portraiture study of four exceptional scholars in education--John Goodlad, John Hoyle, Joseph Murphy, and Thomas Sergiovanni--provides insight into their scholarly work and life habits, direction and aspirations, assessment and analysis of major trends in the profession, and advice for aspiring leaders and academics. Telephone interviews with…
ERIC Educational Resources Information Center
Mullen, Carol A.
2009-01-01
This portraiture study of four exceptional scholars in education--John Goodlad, John Hoyle, Joseph Murphy, and Thomas Sergiovanni--provides insight into their scholarly work and life habits, direction and aspirations, assessment and analysis of major trends in the profession, and advice for aspiring leaders and academics. Telephone interviews with…
Summary of Research Academic Departments.
1987-10-01
I.C ROBERT F. SMITH ADVISER: LIEUTENANT JOSEPH P. GILIO , USN - Heart Rate Treadmill MIDSHIPMAN 2, C JOHN M. SNIEFEN ADVISER: LIEUTENANT COMMANDER...I B t’ V" R S SGe’.chke, Miark 1., 131 Lander.. Rit, P, 218 Gibb, Arthur. fr., 100, 207, 2 10, 2 13 Langan, ’Thomas 1., 38 Gilio , Joseph P, 58 Lanzer
Wide area Hyperspectral Motion Imaging
2017-02-03
LEXINGTON, MASSACHUSETTS 02420-9108 (781) 981-1343 3 February 2017 TO: FROM: Dr. Joseph Lin (joseph.lin@ll.mit.edu), Advanced Imager ...Technology SUBJECT: Wide-area Hyperspectral Motion Imaging Introduction Wide-area motion imaging (WAMI) has received increased attention in...fielded imaging spectrometers use either dispersive or interferometric techniques. A dispersive spectrometer uses a grating or prism to disperse the
Recent theoretical chemical dynamics at Rochester in the paths of Joseph O. Hirschfelder
NASA Technical Reports Server (NTRS)
George, T. F.; Lam, K.-S.; Bhattacharyya, D. K.; Hutchinson, M.; Zimmerman, I. H.; Devries, P. L.; Yuan, J.-M.
1982-01-01
A review of recent theoretical studies of gas-phase molecular rate processes, including various effects of laser radiation, is presented in the context of the extensive and influential work of Joseph O. Hirschfelder during the past half-century. The topics addressed are energy transfer, chemical reactions, unimolecular dissociation, transition states, and bound-continuum interactions.
ERIC Educational Resources Information Center
Bull, Glen; Spector, J. Michael; Persichitte, Kay; Meiers, Ellen
2017-01-01
Joseph South, an educational researcher, technology consultant, and former director of the U.S. Office of Educational Technology participated in a research initiative on Educational Technology Efficacy Research organized by the Jefferson Education Accelerator, Digital Promise, and the Curry School of Education at the University of Virginia. The…
ERIC Educational Resources Information Center
Myers, Phillip E.; Smith, Marie F.
2008-01-01
Research administrators can be assisted in resolving issues with awareness of the critical period of policy formation divulged in the Joseph Warner Papers. He and his colleagues on the Subcommittee on Grants and Contracts Provisions of COGR adopted the philosophy that research administrators needed flexibility and reduced paperwork and costs.…
99mTc-DMSA Uptake in a Sister Mary Joseph's Nodule From Ovarian Cancer.
Naddaf, Sleiman; Azzumeea, Fahad; Fahad Alzayed, Mohammed
2016-12-01
A 50-year-old woman with ovarian cancer underwent Tc-DMSA scan to evaluate the functional status of the right hydronephrotic kidney. The images incidentally revealed a well-defined focus of mild radiotracer uptake at the midanterior abdominal wall, which correlated with a metastatic Sister Mary Joseph's nodule seen on CT performed a week earlier.
The great neurosis of Dr. Joseph Gerard.
Lefrère, Jean-Jacques; Rouillon, Frédéric
2013-01-01
The Great Neurosis, of Dr. Joseph Gerard, was published in 1889 in Paris. The book, intended for the general public, shows the different varieties of neuroses through picturesque and instructive examples. Its scientific and medical value is poor, but provides us with the various meanings of the word 'neurosis' in the late nineteenth century. Copyright © 2013 S. Karger AG, Basel.
Federal Register 2010, 2011, 2012, 2013, 2014
2012-09-04
... Memorial Drive, Kansas City, Missouri 64198-0001: 1. Billy D. Cole and Joy Y. Cole, St. Joseph, Missouri; Nancy Stonner, Blue Springs, Missouri; Norma Cole, Redmond, Washington; Mary Benson, New York, New York; and Thomas Cole, Liberty, Missouri; as a group acting in concert, to acquire control of St. Joseph...
ERIC Educational Resources Information Center
Mendenhall, Annie S.
2011-01-01
This essay provides an account of The Ohio State University's (OSU) rhetoric department during the tenure of Joseph Villiers Denney, arguing that he appropriated and repurposed national trends in education and rhetoric in ways that complicate the narrative of rhetoric and composition's decline in the late nineteenth century. In this essay, the…
New Sensors to Track Head Acceleration during Possible Injurious Events
2009-02-01
Chris Perry John Plaga Biosciences and Protection Division Biomechanics Branch Jesse Bonfeld Endevco 30700 Rancho Viejo Road San Juan...GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 62202F 6. AUTHOR(S) Ted Knox, Joseph Pellettiere, Chris Perry, John Plaga Jesse Bonfeld 5d...Possible Injurious Events Ted Knox, Joseph Pellettiere, Chris Perry, John Plaga AFRL/RHPA Jesse Bonfeld Endevco ABSTRACT Instrumented
ERIC Educational Resources Information Center
de Berg, Kevin C.
2011-01-01
This paper discusses the findings of a search for the intellectual tools used by Joseph Priestley (1733-1804) in his chemistry, education, and theology documents. Priestley's enquiring democratic view of knowledge was applicable in all three areas and constitutes a significant part of his lifework. Current epistemological issues in science…
DCEG Symposium to Honor Joseph F. Fraumeni, Jr. | Poster
By Nancy Parrish, Staff Writer On May 6, the Division of Cancer Epidemiology and Genetics (DCEG) will sponsor a symposium to honor 50 years of leadership from its founding director, Joseph F. Fraumeni, Jr., M.D., who stepped down from the position in July 2012. The conference, entitled “Cancer Epidemiology: From Pedigrees to Populations,” will highlight critical findings in
ERIC Educational Resources Information Center
Watras, Joseph
2014-01-01
Joseph Tobin made an impact on the field of comparative education in 2009 when he used a unique form of ethnography to illuminate the effects of world-wide forces, such as modernization, on schools in specific countries. Earlier, in 1989, he published "Preschool in Three Cultures" with co-authors David Wu and Dana Davidson. The…
Federal Register 2010, 2011, 2012, 2013, 2014
2010-11-29
... NUCLEAR REGULATORY COMMISSION [Docket Nos. 50-348 and 50-364; NRC-2009-0375] Southern Nuclear Operating Company, Inc. Joseph M. Farley Nuclear Plant, Environmental Assessment and Finding of No Significant Impact The U.S. Nuclear Regulatory Commission (NRC) is considering issuance of an Exemption, pursuant to Title 10 of the Code of Federal...
Joseph Woolley--Pioneer of British Naval Education; 1848-1879
ERIC Educational Resources Information Center
Dickinson, H. W.
2007-01-01
For almost 25 years Joseph Woolley served the Admiralty as a teacher, inspector of schools and as the first Admiralty Director of Education. Despite the fact that Woolley held this post for a decade, that he was the sole occupant in the nineteenth century and that in this capacity he gave evidence to, or was a member of, every government committee…
From Chemical Analysis to Analyzing Chemical Education: An Interview with Joseph J. Lagowski
ERIC Educational Resources Information Center
Cardellini, Liberato
2010-01-01
This interview provides glimpses of Joseph J. Lagowski and his life from the time he played with a Gilbert chemistry set, to his tenure at The University of Texas at Austin. His initial interest in chemistry was further nurtured and developed thanks to an excellent high school teacher. In the interview, Lagowski discusses his research in…
Chief Joseph: The Story of an American Indian.
ERIC Educational Resources Information Center
Johnson, R. P.
Written for children in grades 5-9, this biography of the Nez Perce leader, Chief Joseph, describes the conflict between the Nez Perce American Indian tribe and the United States government, known as the Nez Perce War of 1877. Describing the 1,700 mile retreat of those Nez Perce who refused to surrender their lands to white settlers, ranchers, and…
The "Mad Hatter's" Adventures in Education: Joseph King (1860-1943) and the Impact of Personality
ERIC Educational Resources Information Center
Palmer, Amy
2017-01-01
Joseph King (1860-1943), known as the "Mad Hatter" because of his appearance and eccentric manner, was a man who cared very much about education in a wide range of arenas. He was a founder of Mansfield House University Settlement in London and of the peasant arts movement, both philanthropic organisations which aimed to improve the lot…
Composing Self on Narrative Landscapes of Sexual Difference: A Story of Wisdom and Resilience
ERIC Educational Resources Information Center
Estefan, Andrew; Roughley, Robert A.
2013-01-01
This study draws upon recent narrative inquiry research that explored the resilience experiences of 6 young same-sex-attracted men and women (4 men, 2 women; age range = 21-27). This article elucidates the story of one participant, Joseph, a 25-year-old Canadian man. As we conducted the research, Joseph's story stood out for us as having something…
A Queueing Model for Supervisory Control of Unmanned Autonomous Vehicles
2013-09-01
Autonomous Vehicles Joseph DiVita, PhD Robert L. Morris Maria Olinda Rodas SSC Pacific Approved...298 (Rev. 8/98) Prescribed by ANSI Std. Z39.18 09–2013 Final A Queueing Model for Supervisory Control of Unmanned Autonomous Vehicles Joseph...Mission Area: Command and Control, Queueing Model; Supervisory Control; Unmanned Autonomous Vehicles M. O. Rodas U U U U 38 (619)
Is Combat Exposure Predictive of Higher Preoperative Stress in Military Members?
2015-01-26
Bopp, Eric, Joseph USU Project Number: N12-P16 4 TSNRP Research Priorities that Study or Project Addresses Primary Priority Force Health...of the caregiver Other: Principal Investigator: Bopp, Eric, Joseph USU Project Number: N12-P16 5 Background The preoperative...e.g., diabetes, thyroid disorders), and (c) autoimmune disorders (e.g., Sjogren’s syndrome ). Patients arriving to the Preoperative Teaching Unit
High Accuracy Attitude Control of a Spacecraft Using Feedback Linearization
1992-05-01
High Accuracy Attitude Control of a Spacecraft Using Feedback Linearization A Thesis Presented by Louis Joseph PoehIman, Captain, USAF B.S., U.S. Air...High Accuracy Attitude Control of a Spacecraft Using Feedback Linearization by Louis Joseph Poehlman, Captain, USAF Submitted to the Department of...31 2-4 Attitude Determination and Control System Architecture ................. 33 3-1 Exact Linearization Using Nonlinear Feedback
Design and Performance of Ka-Band Fiber-Optic Delay Lines
2012-12-28
Approved for public release; distribution is unlimited. Vincent J. Urick Joseph M. singley christopher e. sUnderMan John F. diehl keith J...PAGES 17. LIMITATION OF ABSTRACT Design and Performance of Ka-Band Fiber-Optic Delay Lines Vincent J. Urick , Joseph M. Singley, Christopher E...Approved for public release; distribution is unlimited. Unclassified Unlimited Unclassified Unlimited Unclassified Unlimited 64 Vincent J. Urick (202
Prototype Development of Low-Cost, Augmented Reality Trainer for Crew Service Weapons
2008-09-01
2008 Thesis Co- Advisors : Mathias Kolsch Joseph Sullivan THIS PAGE INTENTIONALLY LEFT BLANK i NSN 7540-01-280-5500 Standard Form 298 (Rev. 2-89...by: Mathias Kölsch Thesis Co- Advisor Joseph Sullivan Thesis Co- Advisor Mathias Kölsch, Ph.D. Chair, MOVES Academic Committee iv...CURRENT QUALIFICATION AND TRAINING METHODS .........9 1. Weapon Qualification / Killer Tomato ..........9 2. Robo -Ski
Spectral Characterization of RDX, ETN, PETN, TATP, HMTD, HMX, and C-4 in the Mid-Infrared Region
2014-04-01
Samuels Joseph A. Domanico Joseph May Ronald W. Miles, Jr. Augustus W. Fountain III RESEARCH AND TECHNOLOGY DIRECTORATE April 2014 Approved for public ...position unless so designated by other authorizing documents. REPORT DOCUMENTATION PAGE Form Approved OMB No. 0704-0188 Public reporting...AVAILABILITY STATEMENT Approved for public release; distribution is unlimited. 13. SUPPLEMENTARY NOTES *Science Applications International Corporation
2014-12-01
behavior of Aedes aegypti Emadeldin Y. Fawaz1, Sandra A. Allan2, Ulrich R. Bernier2, Peter J. Obenauer3, and Joseph W. Diclaro II1 1Vector Biology... Aedes aegypti swarming behavior and identified associated chemical cues. Novel evidence is provided that Ae. aegypti females aggregate by means of...the isolated aggregation pheromones in controlling Ae. aegypti. Journal of Vector Ecology 39 (2): 347-354. 2014. Keyword Index: Aedes aegypti, swarm
Modeling complex systems in the geosciences
NASA Astrophysics Data System (ADS)
Balcerak, Ernie
2013-03-01
Many geophysical phenomena can be described as complex systems, involving phenomena such as extreme or "wild" events that often do not follow the Gaussian distribution that would be expected if the events were simply random and uncorrelated. For instance, some geophysical phenomena like earthquakes show a much higher occurrence of relatively large values than would a Gaussian distribution and so are examples of the "Noah effect" (named by Benoit Mandelbrot for the exceptionally heavy rain in the biblical flood). Other geophysical phenomena are examples of the "Joseph effect," in which a state is especially persistent, such as a spell of multiple consecutive hot days (heat waves) or several dry summers in a row. The Joseph effect was named after the biblical story in which Joseph's dream of seven fat cows and seven thin ones predicted 7 years of plenty followed by 7 years of drought.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Hiebert, Ray; Hiebert, Roselyn
This brief booklet gives a snapshot view of 25 men, each of whom contributed an important building block to the foundations of atomic science. The 25 men are: Anaxagoras; Archimedes; Avogadro, Amedeo; Berthollet, Claude Louis; Berzelius, Jons Jakob; Boyle, Robert; Bruno, Giordano; Copernicus; Dalton, John; Davy, Humphry; Democritus; Descartes, Rene; Empedocles; Fpicurus; Franklin, Benjamin; Galilei, Galileo; Gassendi, Pierre; Gay-Lussac, Joseph Louis; Lavoisier, Antoine; Leucippus; Lucretius; Newton, Isaac; Proust, Joseph Louis; Pythagoras; and Wollaston, William Hyde.
The Economic Foundations of Operational Art
1992-05-20
War. Prior ti the Industrial Revolution , which happened to coincide closely with the take-off stage, the tools available to the operational artist were...in the age of high mass consumption. "ePowell, R. A. ’Microelectronics.’ Windows on a New World: The Third Industrial Revolution . Joseph Finkelstein...Finkelstein, Joseph, Window on a New World, The Third Industrial Revolution . Nw YorK: Greenwood Press, 1989. Haythornthwaite, Philip J., Napoleon’s
Chief Joseph Dam, Columbia River, Washington, Community Impact Reports,
1980-05-01
provide a major source of employment. Forested areas in the north and east pro- vide raw materials for an active lumber and wood products industry...Sewage Disposal Systems. The District Engineer of the Washington State Department of Ecology furnished the design flow capacity and its population...latter is without consideration of Chief Joseph Dam contruction impact. The high school is rated 1. 4.03 The individual residents are responsible for
Trading Freshness for Performance in Distributed Systems
2014-12-01
Systems (IOPADS ’99), May 1999. 3.6 Charles Babcock. Data, data, everywhere. Information Week, January 2006. 3.2 Peter Bailis, Shivaram Venkataraman ... Venkataraman , Michael J. Franklin, Joseph M. Hellerstein, and Ion Stoica. Pbs at work: Advancing data management with consistency metrics. In Proceedings of...5. doi: 10.1145/2463676.2465260. URL http://doi.acm.org/10. 1145/2463676.2465260. 2.4 Peter Bailis, Shivaram Venkataraman , Michael J. Franklin, Joseph
Large Scale Cross Drive Correlation Of Digital Media
2016-03-01
NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS LARGE SCALE CROSS-DRIVE CORRELATION OF DIGITAL MEDIA by Joseph Van Bruaene March 2016 Thesis Co...CROSS-DRIVE CORRELATION OF DIGITAL MEDIA 5. FUNDING NUMBERS 6. AUTHOR(S) Joseph Van Bruaene 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Naval...the ability to make large scale cross-drive correlations among a large corpus of digital media becomes increasingly important. We propose a
Military Air Cargo Containerization.
1996-05-01
MILITARY AIR CARGO CONTAINERIZATION GRADUATE RESEARCH PAPER Joseph W. Mancy, Major, USAF AFIT/ GMO /LAL/96J-4 : ."•" ’* ■- ’ DEPARTMENT OF...Approved to public release; Distribution UnHmlted ? DTIC QUALITY INSPECTED 1 AFIT/ GMO /LAL/96J-4 MILITARY AIR CARGO CONTAINERIZATION GRADUATE RESEARCH...PAPER Joseph W. Mancy, Major, USAF AFIT/ GMO /LAL/96J-4 19960617 134 Approved for public release; distribution unlimited The views expressed in this
Sleep/Wakefulness Management in Continuous/Sustained Operations
2002-11-01
SEINE CEDEX, FRANCE RTO LECTURE SERIES 223 Sleep/Wakefulness Management in Continuous/Sustained Operations (La gestion des rythmes veille/sommeil lors... Management in Continuous/Sustained Operations (La gestion des rythmes veille/sommeil lors des opérations continues/soutenues) The material in this...St. Joseph Print Group Inc. (A St. Joseph Corporation Company) 1165 Kenaston Street, Ottawa, Ontario, Canada K1G 6S1 ii Sleep/Wakefulness Management in
Operational Maneuver: Function or Fiction?
1996-02-12
characteristics of Vego’s operational functions. Although Schroedel’s model was constructed for the art and science of operational maneuver, his model...Schroedel, Joseph. "The Art and Science of operational Maneuver. " Fort Leavenworth, Kansas, SAMS Monograph, 1988, p. 5. 3 U.S. Joint Chiefs of Staff...Important Than Others? Ft. Leavenworth, Kansas: Study, 1986. Schroedel, Joseph. "The Art and Science of Operational Maneuver." Ft. Leavenworth, Kansas: SAMS
Soldier Capability - Army Combat Effectiveness (SCACE). Volume 2. Selected Bibliography
1981-02-01
Human Resources Research Office, June 1963. 388. McLachlan, Joseph C., et al. Navy-Wide Standardized Proficiency Testing Program for Fleet JEZEBEL...Directorate of Evaluation, August 1979. 428. Olmstead, Joseph A., et al. Research on Training for Brigade Com- mand Groups: Factors Contributing to Unit...orormance Human Rsurces Research Organization, August 1972. 686. Vitola, B. M., Guinn, N., and Wilbourn , J. N. acm o Various Enlistment Standards on
Fire Performance Evaluation of Solid Aqueous Film-Forming Foam (AFFF).
1986-05-01
Aqueous Film - Forming Foam ( AFFF ) Concentrates as Firefighting Agents, USAF Report ESL-TR-81-18, Tyndall Air Force Base, Florida...Evaluation of Solid Aqueous Film - Forming Foam ( AFFF ) JOSEPH L. SCHEFFEY HUGHES ASSOCIATES, INC. , EDWIN J. JABLONSKI 2730 UNIVERSITY BLVD. W. JOSEPH T...performance evaluation of the solid agent is the 28-square-foot fire test described in ’L F-24385C, Military Specification for Aqueous Film - Forming
Evaluation of Government Quality Assurance Oversight for DoD Acquisition Programs
2014-11-03
W. Edwards Deming , Joseph M. Juran,” July 1992, the Aerospace Standard (AS) 9100, and an industrially recognized quality management handbook... Deming , Joseph M. Juran,” July 1992, and Juran’s Quality Handbook (5th Edition). The Navy TQLO publication summarizes the best practices developed by...world renowned quality management experts who have set quality management best practices for more than 50 years ; Philip B. Crosby, W. Edwards Deming , and
Remembering Joseph Mayo and His Contributions to Animal Science | Poster
By Carolynne Keenan, Guest Writer In the 1990s, when Joseph Mayo, D.V.M, ran out of gas leading coworkers home from a meeting in Bethesda, he pulled over to the side of the road on I-270 and waited for help. He didn’t have to wait long; within a few minutes a passing motorist took pity on the group of scientists and offered them a lift back to Fort Detrick.
Astronaut Joseph P. Allen, STS-5 crew member, in front of open hatch
NASA Technical Reports Server (NTRS)
1982-01-01
Astronaut Joseph P. Allen, right, STS-5 mission specialist, slips on jacket portion of his Shuttle constant-wear garment in the White room at Launch Pad 39A at the Kennedy Space Center (KSC). Astronaut William B. Lenoir, STS-5's other mission specialist, left, waits to enter the Columbia, whose open hatch is at center. Electrodes on Allen's face and head are for monitoring his reflexes during launch.
Variable Rail Voltage Control of a Brushless DC (BLDC) Motor
2013-01-01
Variable Rail Voltage Control of a Brushless DC ( BLDC ) Motor by Yuan Chen, Joseph Conroy, and William Nothwang ARL-TR-6308 January 2013...TR-6308 January 2013 Variable Rail Voltage Control of a Brushless DC ( BLDC ) Motor Yuan Chen, Joseph Conroy, and William Nothwang Sensors...DATES COVERED (From - To) 4. TITLE AND SUBTITLE Variable Rail Voltage Control of a Brushless DC ( BLDC ) Motor 5a. CONTRACT NUMBER 5b. GRANT
American Military History and its Insights into Fourth Generation Warfare
2006-01-01
8William S . Lind, Colonel Keith Nightengale (USA), Captain John F. Schmitt (USMC), Colonel Joseph W. Sutton (USA), and Lieutenant Colonel Gary I. Wilson...Lind, William S ., Colonel Keith Nightengale (USA), Captain John F. Schmitt (USMC), Colonel Joseph W. Sutton (USA), and Lieutenant Colonel Gary I...military history and its insights into fourth generation warfare. 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR( S
ERIC Educational Resources Information Center
Schwieler, Elias
2013-01-01
Joseph Conrad's "The Secret Sharer" has often been associated with what can be called initiation stories. However, in this article I argue that Conrad's text is more than that. It can, I suggest, be read as an allegory of the inaccessibility to reveal the essence of being in command, being in education, and also the…
Science, alchemy and light: paintings by Joseph Wright of Derby.
Dominiczak, Marek H
2002-01-01
This article considers two paintings by the English painter, Joseph Wright of Derby (1734-97), 'An Experiment on a Bird in the Air Pump' and 'The Alchemist in Search of the Philosopher's Stone' as painterly reflections on the early industrial culture. Particularly interesting in the "Experiment on a Bird" is the broad spectrum of spectator's reactions to the experiment; this can be related to the contemporary debate on the contextualization of science.
ERIC Educational Resources Information Center
Needham, Scott
A guide, in French, to raising fish for food and profit is designed to instruct and encourage Gabonese natives to establish family fisheries. It describes and illustrates in story form the process used to plan the fishery, clear the land, seek help from an agricultural agent, create a dam, make compost, plan and build the pond, feed the fish,…
Code of Federal Regulations, 2014 CFR
2014-07-01
... 33 Navigation and Navigable Waters 3 2014-07-01 2014-07-01 false Gulf of Mexico south and west of Apalachicola, San Blas, and St. Joseph bays; air-to-air firing practice range, Tyndall Air Force Base, Fla. 334..., DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.670 Gulf of Mexico south and west of...
Code of Federal Regulations, 2011 CFR
2011-07-01
... 33 Navigation and Navigable Waters 3 2011-07-01 2011-07-01 false Gulf of Mexico south and west of Apalachicola, San Blas, and St. Joseph bays; air-to-air firing practice range, Tyndall Air Force Base, Fla. 334..., DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.670 Gulf of Mexico south and west of...
Code of Federal Regulations, 2012 CFR
2012-07-01
... 33 Navigation and Navigable Waters 3 2012-07-01 2012-07-01 false Gulf of Mexico south and west of Apalachicola, San Blas, and St. Joseph bays; air-to-air firing practice range, Tyndall Air Force Base, Fla. 334..., DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.670 Gulf of Mexico south and west of...
Code of Federal Regulations, 2013 CFR
2013-07-01
... 33 Navigation and Navigable Waters 3 2013-07-01 2013-07-01 false Gulf of Mexico south and west of Apalachicola, San Blas, and St. Joseph bays; air-to-air firing practice range, Tyndall Air Force Base, Fla. 334..., DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.670 Gulf of Mexico south and west of...
Astronaut Joseph Kerwin takes blood sample from Astronaut Charles Conrad
NASA Technical Reports Server (NTRS)
1973-01-01
Scientist-Astronaut Joseph P. Kerwin (right), Skylab 2 science pilot and a doctor of medicine, takes a blood sample from Astronaut Charles Conrad Jr., Sylab 2 commander, as seen in this reproduction taken from a color television transmission made by a TV camera aboard the Skylab 1 and 2 space station cluster in Earth orbit. The blood sampling was part of the Skylab Hematology and Immunology Experiment M110 series.
Wildlife Habitat Impact Assessment, Chief Joseph Dam Project, Washington : Project Report 1992.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Kuehn, Douglas; Berger, Matthew
1992-01-01
Under the Pacific Northwest Electric Power Planning and Conservation Act of 1980, and the subsequent Northwest Power Planning Council`s Columbia River Basin Fish and Wildlife Program, a wildlife habitat impact assessment and identification of mitigation objectives have been developed for the US Army Corps of Engineer`s Chief Joseph Dam Project in north-central Washington. This study will form the basis for future mitigation planning and implementation.
Evaluation of the United States Drug War Policy Abroad: A Case Study in Colombia
2010-12-01
Case Study in Colombia By: Kevin T. Wright and Joseph S. Hamilton December 2010 Advisors: David R. Henderson, John Enns...States Drug War Policy Abroad: A Case Study in Colombia 6. AUTHOR(S) Kevin T. Wright, Joseph S. Hamilton 5. FUNDING NUMBERS 7. PERFORMING...public release; distribution is unlimited EVALUATION OF THE UNITED STATES DRUG WAR POLICY ABROAD: A CASE STUDY IN COLOMBIA Kevin T. Wright
Developing Cyberspace Data Understanding: Using CRISP-DM for Host-based IDS Feature Mining
2010-03-01
Developing Cyberspace Data Understanding: Using CRISP - DM for Host-based IDS Feature Mining THESIS Joseph R. Erskine, Captain, USAF AFIT/GCS/ENG/10-01...Air Force, Department of Defense, or the United States Government. AFIT/GCS/ENG/10-01 Developing Cyberspace Data Understanding: Using CRISP - DM for...Developing Cyberspace Data Understanding: Using CRISP - DM for Host-based IDS Feature Mining Joseph R. Erskine, B.S.C.S. Captain, USAF Approved: /signed/ 12
Correlation of HIFiRE-5 Flight Data with Computed Pressure and Heat Transfer (Postprint)
2015-06-01
AFRL-RQ-WP-TP-2015-0149 CORRELATION OF HIFiRE-5 FLIGHT DATA WITH COMPUTED PRESSURE AND HEAT TRANSFER (POSTPRINT) Joseph S. Jewell...results with St was compared to flight heat transfer measurements, and transition locations were inferred. Finally, a computational heat conduction...HIFiRE-5 Flight Data With Computed Pressure and Heat Transfer Joseph S. Jewell,1 James H. Miller,2 and Roger L. Kimmel3 U.S. Air Force Research
Astronaut Paul Weitz gets physical examination from Astronaut Joseph Kerwin
NASA Technical Reports Server (NTRS)
1973-01-01
Astronaut Paul J. Weitz, Skylab 2 pilot, gets a physical examination by a fellow crewman during the 28-day Skylab 2 mission. Scientist-Astronaut Joseph P. Kerwin, Skylab 2 science pilot and a doctor of medicine, uses a stethoscope to check the Weitz's heartbeat. They are in the Orbital Workshop crew quarters of the Skylab 1 and 2 space station in Earth orbit. This photograph was taken by Charles Conrad Jr., Skylab 2 commander.
China in Africa: America’s Soft Power Challenge
2011-05-01
22 MCU/CSC/Merrill, T.E./ A Y11 BffiLIOGRAPHY Bergsten, C. Fred, Bates Gill, Nicholas R. Lardy, and Derek Mitchell. China: The Balance Sheet: What...Tiyambe Zeleza. "Africa." World Book Advanced. World Book, 2011. Web. 5 Mar. 2011. Eisenman, Joshua, Eric Heginbotham, and Derek Mitchell, eds. China...docLib/20070726 WhatAfricomMeansforAfrica.pdf. Nye, JosephS. Bound to Lead: The Changing Nature of American Power. New York: Basic Books, 1990. Ong
The Global Logistics Command: A Strategy to Sustain the Post-War Army
2014-05-22
Logistics: Determining Relevance for 21st Century Operations,” 17. 56Jobson and Antell, U.S. Army Materiel Command, 23. Joseph M. Heiser Jr., “Supply...mechanization expanded. Heiser , “Supply Support in Vietnam,” 37. 24 lacked.58 He also formalized in-theater training with two teams, codenamed Project...Airborne Corps History Office, Fort Bragg, NC, 2010. Heiser , Joseph M. Jr. Vietnam Studies Logistics Support. Washington, DC: U.S. Army Center of
Basic Perception in Head-worn Augmented Reality Displays
2012-01-01
Basic Perception in Head-worn Augmented Reality Displays Mark A. Livingston, Joseph L. Gabbard , J. Edward Swan II, Ciara M. Sibley, and Jane H...mark.livingston@nrl.navy.mil Joseph L. Gabbard Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA e-mail: jgabbard@vt.edu J...Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 2 Livingston, Gabbard , et al. 1 Introduction For many first-time users of augmented reality
Electrochemical and Photochemical Treatment of Aqueous Waste Streams
1996-01-01
TREATMENT OF AQUEOUS WASTE STREAMS Joseph C. Farmer, Richard W. Pekala, Francis T. Wang, David V. Fix, Alan M. Volpe, Daniel D. Dietrich, William H...STREAMS Joseph C. Farmer, Richard W. Pekala, Francis T. Wang, David V. Fix, Alan M. Volpe, Daniel D. Dietrich, William H. Siegel and James F. Carley...1992). Wilbourne , C. M. Wong, , W. S. Gillam, S. Johnson, R. H. Horowitz, "Electrosorb Process for Desalting Water," Res. Dev. Prog. Rept. No. 516, 16. J
Duris, Joseph W.; Reeves, Howard W.; Kiesler, James L.
2005-01-01
The U.S. Geological Survey (USGS) sampled multiple stream sites across the St. Joseph and Galien River Basins to detect and quantify the herbicide atrazine using a field enzyme-linked immunosorbent assay (ELISA) triazine test. In May 2001, July 2001, April 2002, August 2002, August 2003 and September 2003, composite samples were collected across streams at USGS streamflow-gaging stations. Concentrations and instantaneous loading for atrazine sampled in stream water throughout the St. Joseph River and Galien River Basins in Michigan and Indiana ranged from nondetection (< 0.05 part per billion (ppb)) with an associated load less than 0.001 kilogram per day (kg/d) to 6 ppb and a maximum load of 10 kg/d. Atrazine concentrations were highest in May 2001 just after the planting season. The lowest concentration was found in April 2002 just before planting. Atrazine concentrations in streambed-sediment pore water were not spatially connected with atrazine concentrations in stream-water samples. This study showed that atrazine concentrations were elevated from May to July in the St. Joseph and Galien River Basins. At many sites, concentrations exceeded the level that has been shown to feminize frog populations (0.2 ppb). There were 8 sites where concentrations exceeded 0.2 ppb atrazine in May 2001 and July 2001.
Staging Options for the Air Force’s Electronic Combat Test Capability: a Cost Analysis
1990-09-01
strategic in nature and completely different than daily operating decisions (20:6). Horngren , in his book Cost Accounting : A Managerial Emphasis...AFIT/GCA/LSY/90S-3 DTTC S E-191 J) C, STAGING OPTIONS FOR THE AIR FORCE’S ELECTRONIC COMBAT TEST CAPABILITY: A COST ANALYSIS THESIS Joseph J. Landino...Alternative Costs ......... 56 v AFIT/GCA/LSY/90S-3 Abstract This study’s purpose was to identify the lowest cost aircraft staging base( s ) for the Air
[Historical note: in homage to Lister].
Ledermann D, Walter
2008-10-01
Joseph Lister, who disputes with Klebs the third place as the Father of Microbiology, was just about to remain without a bacteria immortalizing his ñame. Thanks to Seeliger, now Listeria is used for identifying the genus that Pirie had already named Listerella in 1927. Through a quick review of the history of Listeria monocytogenes, we get to know the principal facts in the lives of Pirie and Seeliger, investigators with absolutely different characters. We also review a brief history of the life of the great researcher Lister, whose profound human qualities are described.
2016-10-01
Righting Reflex of rats following double blast exposure. 0 4 8 12 16 20 R ig ht in g Re fle x (m in ut es ) PLACEBO FISH OIL Total Lived Died...experiments. Funding Support: Geneva Foundation contractor – WRAIR Name: Joseph B. Long, Ph.D. Project Role: Co-Investigator – WRAIR Researcher...Funding Support: Clinical Research Management contractor Name: Andrew B. Batuure Project Role: Technician - WRAIR Researcher Identifier (e.g. ORCID
NASA Astrophysics Data System (ADS)
Nasholds, M. W.; Karlstrom, L.; Morriss, M. C.
2016-12-01
The Chief Joseph dike swarm, spanning northeastern OR, southeastern WA, and parts of western ID, is one of the primary dike swarms feeding the mid-Miocene Columbia River Basalt Group (CRBG) (e.g. Reidel et al. 2013). William H. Taubeneck (1923-2016) mapped these and other CRBG feeder dikes over 40 years, generating an expansive dataset with locations and characteristics of dike segments, primarily centered within the Wallowa Mountains, extending as far north as Lewiston, ID, and as far south as Farewell Bend, OR. Taubeneck is credited with originally defining the Chief Joseph swarm, but his data was not made available until his death. Using ArcMap, we are in the process of digitizing, field checking, and making available relevant data from Taubeneck's annotated maps and notebooks. We extract dike locations, orientations, thicknesses, and host rock characteristics. We present an overview of the Taubeneck data, relating to Chief Joseph dikes in WA, ID, and newer field measurements in the Wallowas, OR. Strikes of the 4410 dike segments range from NNW to NNE, with outliers that define smaller clusters with distinct orientations. The dikes have primarily near-vertical dips, paleo-depths ranging from 2 km to 0.3 km, and limited observations indicate widths from <5 m to 40 m. A majority of dikes are exposed in uplifted granites of the Wallowa batholith and metamorphosed host: 1606 dikes occur in quartz diorite, 60 occur in the Hurwal Formation, 139 occur in metavolcanics, while 401 occur in CRBG basalt. The other 2204 dikes are not in the Chief Joseph area. There does not seem to be a significant relation between host rock composition and dike orientation, although wall rock interactions are more dramatic in non-granitic Tertiary rocks. This dataset may provide further insight into both dike emplacement dynamics and the plumbing system of the CRBG.
Archaeological Investigations at Site 45-DO-282, Chief Joseph Dam Project, Washington
1984-01-01
and Mr. Joseph, in particular. Excavations at 45-00-282 were carried out by a joint Western Washington University and University of Washington field...not terminate in a snap fracture . A few have been snapped jcross both the dorsal and proximal ends. Except for these few C4’ aa CL, cw V. .f q-1f1410... fractures , it is virtually •-:1 impossible to classify breakage as Intentional, or as an accidental product of manufacture. Many of the core flutes
2015-06-01
REPORT unclassified b. ABSTRACT unclassified c . THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 United...GAO-15-544. For more information, contact Joseph W. Kirschbaum at (202) 512- 9971 or kirschbaumj@gao.gov or Gregory C . Wilshusen at (202) 512-6244 or...Joseph W. Kirschbaum at (202) 512-9971 or KirschbaumJ@gao.gov or Gregory C . Wilshusen at (202) 512-6244 or WilshusenG@gao.gov. Contact points for
Astronaut Joseph Tanner is assisted into his EMU during training
NASA Technical Reports Server (NTRS)
1994-01-01
Astronaut Joseph R. Tanner, STS-66 mission specialist, is assisted by Boeing suit expert Steve Voyles in donning the gloves for his extravehicular mobility unit (EMU) as he prepares to be submerged in a 25-feet deep pool at JSC's Weightless Environment Training Facility (WETF). Though no extravehicular activity (EVA) is planned for the mission, at least two astronauts are trained to perform tasks that would require a space walk in the event of failure of remote systems.
Astronaut Joseph R. Tanner works with PCG experiment on middeck
1994-11-14
On the Space Shuttle Atlantis' mid-deck, astronaut Joseph R. Tanner, mission specialist, works at area amidst several lockers onboard the Shuttle which support the Protein Crystal Growth (PCG) experiment. This particular section is called the Crystal Observation System, housed in the Thermal Enclosure System (COS/TES). Together with the Vapor Diffusion Apparatus (VDA), housed in a Single Locker Thermal Enclosure (SLTES) which is out of frame, the Cos/TES represents the continuing research into the structures of proteins and other macromolecules such as viruses.
[Franz Joseph Gall and his "talking skulls" established the basis of modern brain sciences].
Wolfgang, Regal; Michael, Nanut
2008-01-01
The anatomist and brain scientist Franz Joseph Gall (1758-1828) developed the "phrenology" in the early 19(th) century. At this time, his new teachings were more seen as a temporary fashion than science and were discredited. No more than hundred years ago, it was realised that the phrenology established the basis of modern brain sciences. By all means Gall was the first one to combine defined regions of the cerebral cortex with distinct cognitive functions.
Matched Filtering of Visual Evoked Potentials to Detect Acceleration (+Gz) Induced Blackout
1985-01-03
FILTERING OF VISUAL EVOKED POTENTIALS rO DETECT ACCELERATION ( + Gz) INDUCED BLACKOUT John Q. Nelson, Leonid Hrebien and Joseph P. Cammarota Aircraft...8217: , r .,.V -. 1-». .v. IE •> _"->.-"*« A^V :j% _"«;_"V X~«. _~»^"V.i.~» iuTtuTii i."»..-^. .-*._> r /; NOTICES REPORT NUMBERING SYSTEM - The...Potentials to Detect Acceleration (+G2) Induced Blackout 12 PERSONAL AUTHOR(S) John G. Nelson, Leonid Hrebien, Joseph P. Cammarota 13* TYPE OF REPORT
Kallmann Syndrome: Eugenics and the Man behind the Eponym
Benbassat, Carlos A.
2016-01-01
Kallmann syndrome is named after Franz Joseph Kallmann, a German-born psychiatrist who described in 1944 twelve subjects from three families who presented with a syndrome of missed puberty, anosmia, and color blindness. Yet, several other eponyms for the same syndrome can be found in the literature. Despite the fact that Kallmann syndrome is the most recognized eponym, very little is known about the man for whom the syndrome is named. A biographical note on Franz Joseph Kallmann and his historical context is presented. PMID:27101217
Analysis of Disaster Planning in Business and Industry
1993-04-01
Alternatives, 13 May 1991, 1. 13. Deegan , Joseph, and Jack Jolley. "Selling Crisis Management." Security Management Jun 1985, 50. 14. Atkin, Leslie, ed. "PG... Deegan , Joseph, and Jack Jolley. "Selling Crisis Management." Security Management Jun 1985, 50. 16. Carey, John. "Getting Business to Think About the...1985, 5. 22. Aronoff, Craig E., and John L. Ward. "Why Owners Don’t Plan." Nation’s Business Jun 1990, 59. 23. Phelps, Norman L. "Setting Up a Crisis
Archival Evaluation of Floodwall Alignments: New Orleans, Louisiana.
1983-11-15
Pedesclaux, 9/9/1797, 5/2/1805. 7. Act lost. See P. Pedesclaux 9/9/1797. 3 arpents. 8. Etienne de Vaugine de Nieuamor to Jacinto Panis, J. B. Garic 8/2...1779. 9. See M. de Armas, 5/27/1818. 10. Joseph Verloin DeGruy to Santiago Livaudais, Andres Almonaster, 10/26/1776. 11. Madame Panis to John N...adds a new owner to the chain of title. Act of Sale, 12/21/1763. 11. N. Broutin 9/6/1810. Ursuline Nuns to Joseph De Ville
2013-05-23
great and MACV decided not to implement the program in total. 13 Lieutenant General Joseph M Heiser , Jr. served as the commander of the 1 st...13 Jeffery Clarke, Advice and Support: The Final Years 1965-1973 (Washington: Department of the Army, 1988), 427-429. 14 Joseph M. Heiser , Vietnam...focused on a redistribution of weapon systems. According to Heiser , The phasedown of U.S. operations in Southeast Asia permitted an accelerated delivery
Arthur Conan Doyle, Joseph Bell, and Sherlock Holmes. A neurologic connection.
Westmoreland, B F; Key, J D
1991-03-01
Neurologists, like physicians in several other medical specialties, can lay claim to Sherlock Holmes as one of their own. This assertion is validated by the number of neurologic conditions, such as seizures, stroke, syncope, encephalopathies, and head trauma, that are mentioned in the stories and novels. In addition, the article reviews the powers of observation and the deductive approach utilized by Conan Doyle and Joseph Bell, the models for Sherlock Holmes, and how these skills can be applied to medical problems.
Observation, Sherlock Holmes, and Evidence Based Medicine.
Osborn, John
2002-01-01
Sir Arthur Conan Doyle, the creator of the fictional detective Sherlock Holmes, studied medicine at the University of Edinburgh between 1876 and 1881 under Doctor Joseph Bell who emphasised in his teaching the importance of observation, deduction and evidence. Sherlock Holmes was modelled on Joseph Bell. The modern notions of Evidence Based Medicine (EBM) are not new. A very brief indication of some of the history of EBM is presented including a discussion of the important and usually overlooked contribution of statisticians to the Popperian philosophy of EBM.
ASTRONAUT KERWIN, JOSEPH P. - EXTRAVEHICULAR ACTIVITY (EVA) - SKYLAB (SL)-2
1973-06-01
S73-27562 (June 1973) --- Scientist-astronaut Joseph P. Kerwin, Skylab 2 science pilot, performs extravehicular activity (EVA) at the Skylab 1 and 2 space station cluster in Earth orbit, as seen in this reproduction taken from a color television transmission made by a TV camera aboard the station. Kerwin is just outside the Airlock Module. Kerwin assisted astronaut Charles Conrad Jr., Skylab 2 commander, during the successful EVA attempt to free the stuck solar array system wing on the Orbital Workshop. Photo credit: NASA
Effect of Dietary Intervention on Prostate Tumor Development in TRAMP Mice
2007-05-01
92, 3439-3443. 5. Gingrich,J.R., Barrios ,R.J., Morton,R.A., Boyce,B.F., DeMayo,F.J., Finegold,M.J., Angelopoulou,R., Rosen,J.M., and Greenberg,N.M...increases survival time in TRAMP mice Melissa J.L. Bonorden, Olga P. Rogozina, Michael E. Grossmann, Christina M. Kluczny, Patricia L. Grambsch, Joseph...TRAMP mice Melissa J.L. Bonorden, Olga P. Rogozina, Michael E. Grossmann, Christina M. Kluczny, Anna Lokshin, Patricia L. Grambsch, Joseph P. Grande
ERIC Educational Resources Information Center
Manz, Patricia H.
2007-01-01
Joseph Zins was a forerunner in empirically demonstrating the interrelationship of SEL interventions and school success. This commentary highlights his perspectives on the accumulating body of evidence for the academic gains that have been associated with various SEL interventions and aims to show how new research methodologies can further extend…
Air Force Human Resources Laboratory Annual Report Fiscal Year 1984,
1985-07-01
Wilbourn AFHRL/MOAE AFHRL/MOAE Brooks AFB, TX 78235-5000 Brooks AFB, TX 78235-5000 Commercial (512) 536-3256 Commercial (512) 536-3256 AUTOVON 240-3256...the-job training. Dr Joseph Yasutake Technical Advisor 142 .-m -- m Immmm ..jmmmmm mm mmmmmmm1mm n m COMMAND STAFF PERSONNEL - e Mr. Robert L. lady...initial big-step improvements can be made. The subthrusts have been the subject of unusually Lt Col Joseph A. Dirt high-level interest. Special scientific
Combat Search and Rescue: Searching the History; Rescuing the Doctrine
2003-06-01
crew search effort KIA 23-Feb USMC Pride 16 AV-8 Capt Wilbourn none KIA 25-Feb USMC Jump 42 AV-8 Capt Walsh none Recovered by USMC in minutes USMC...61 Hallion, Richard P. Storm Over Iraq Air Power and the Gulf War. Washington, D.C.: Smithsonian Institution Press, 1992. Hampton, Lt Col Joseph C...Operation DESERT SHIELD Combat SAR Plan, 1 November 1990, in JPRA library. (Secret) Hampton, Lt Col Joseph C. Joint Universal Lessons Learned
The Marshall Plan as Strategic Analogy: Implications for Post-Conflict Reconstruction Planning
2014-12-04
Richard E. and Ernest R. May. Thinking in Time: The Use of History for Decision Makers. New York: The Free Press, 1986. Nye, Joseph S., Jr . The...Joseph R. Biden, Jr ., “Opening Statement in the Senate Foreign Relations Committee Hearing on Afghanistan – Time for a New Strategy?” United States... Ernest R. May, government and history professors at Harvard University, argue that “[s]eeing the past can help one envision alternate futures. But, we
Astronaut Joseph Kerwin strapped into sleep restraint in crew quarters
1973-06-01
Scientist-Astronaut Joseph P. Kerwin, Skylab 2 science pilot, is photographed strapped into the sleep restraint in the crew quarters of the Orbital Workshop of the Skylab 1 and 2 space station cluster in Earth orbit. Kerwin is wearing the special cap which contains biomedical instrumentation for the M133 Sleep Monitoring Experiment. The purpose of the M133 experiment is to evaluate quantity and quality of sleep during prolonged space flight by the analysis of electroencephalographic (EEG) and electrooculographic (EOG) activity.
2008-12-01
of relying upon the minimalist idea of maintaining strategic deterrence only to prevent nuclear attack.[87] Joseph Pilat agrees and tries to make...Record Straight,” The Washington Quarterly 28, no. 3 (Summer 2005): 136. 87. Payne (2005), Op. Cit., 140. 88. Pilat , Op. Cit., 43. 89. Payne (2005...152. 91. Payne (2005), Op. Cit., 142. 92. Ibid., 146. 93. Joseph F. Pilat , “The New Triad,” in Wirtz and Larson, eds., Nuclear Transformation
Cao, Yong; Chu, Yuchuan; He, Xiaoming; ...
2013-01-01
This paper proposes a domain decomposition method for the coupled stationary Navier-Stokes and Darcy equations with the Beavers-Joseph-Saffman interface condition in order to improve the efficiency of the finite element method. The physical interface conditions are directly utilized to construct the boundary conditions on the interface and then decouple the Navier-Stokes and Darcy equations. Newton iteration will be used to deal with the nonlinear systems. Numerical results are presented to illustrate the features of the proposed method.
1988-09-01
Test and Evaluation Report Test and Evaluation of the Navy Technical Information Presentation System (NTIPS) F-14A Field Test Results by .0 Joseph J...PROGRAM PROJECT TASK WORK UNIT Washington, D.C. 20361 ELEMENT NO. NO. NO. ACCESSION NO. OMN 1820 11. TITLE (Include Security Classification) TEST AND...EVALUATION OF THE NAVY TECHNICAL INFORMATION PRESENTATION SYSTEM (NTIPS) F-14A FIELD TEST RESULTS 12. PERSONAL AUTHOR(S) Fuller, Joseph F. (DTRC) Post
DOE Office of Scientific and Technical Information (OSTI.GOV)
Lockwood, Jr., Neil; McLellan, Jason G; Crossley, Brian
The Resident Fish Stock Status above Chief Joseph and Grand Coulee Dams Project, commonly known as the Joint Stock Assessment Project (JSAP) is a management tool using ecosystem principles to manage artificial fish assemblages and native fish in altered environments existing in the Columbia River System above Chief Joseph and Grand Coulee Dams (blocked area). The three-phase approach of this project will enhance the fisheries resources of the blocked area by identifying data gaps, filling data gaps with research, and implementing management recommendations based on research results. The Blocked Area fisheries information housed in a central location will allow managersmore » to view the entire system while making decisions, rather than basing management decisions on isolated portions of the system. The JSAP (NWPPC program measure 10.8B.26) is designed and guided jointly by fisheries managers in the blocked area and the Columbia Basin blocked area management plan (1998). The initial year of the project (1997) identified the need for a central data storage and analysis facility, coordination with the StreamNet project, compilation of blocked area fisheries information, and a report on the ecological condition of the Spokane River System. These needs were addressed in 1998 by acquiring a central location with a data storage and analysis system, coordinating a pilot project with StreamNet, compiling fisheries distribution data throughout the blocked area, identifying data gaps based on compiled information, and researching the ecological condition of the Spokane River. In order to ensure that any additional information collected throughout the life of this project will be easily stored and manipulated by the central storage facility, it was necessary to develop standardized methodologies between the JSAP fisheries managers. The use of common collection and analytical tools is essential to the process of streamlining joint management decisions. In 1999 and 2000 the project began to address some of the identified data gaps, throughout the blocked area, with a variety of newly developed sampling projects, as well as, continuing with ongoing data collection of established projects.« less
Theater in professor Charcot's galaxy.
Poirier, Jacques; Philippon, Jacques
2013-01-01
Jean-Martin Charcot, famous professor of the Chair of Clinic for Diseases of the Nervous System at Salpêtrière Hospital in Paris, was himself an artist, surrounded by artists, and adored the theater. His close colleague Charles Brown-Séquard was ridiculed by Georges Feydeau in a brief freakish monologue recited by Coquelin Cadet, from the Comédie-Française, concerning his claims to rejuvenate himself and others with animal testicle extracts. His friend and patient Alphonse Daudet had written many novels, short stories, and plays. Léon Daudet, Alphonse Daudet's son (and friend of Jean-Baptiste Charcot, the son of the professor), after having abandoned his medical studies, became a writer whose novel Les morticoles was a cruel satire of the medical profession. Among Charcot's pupils, Alfred Binet, Gilbert Ballet, Édouard Brissaud, and Joseph Babinski were particularly involved in the theater. Gilbert Ballet wrote the foreword to La folie au théâtre (Madness in Theatre) by André de Latour. Édouard Brissaud wrote a satiric play Le chèque (The Check), and Joseph Babinski, under the pseudonym of Olaf, was the coauthor with Palau of the drama Les détraquées (The Deranged Women). However, when all is said and done, perhaps the greatest actor in his entourage was Charcot himself. Copyright © 2013 S. Karger AG, Basel.
Water quality and discharge data for St. Joseph Bay, Florida, 1997-98
Berndt, M.P.; Franklin, M.A.
1999-01-01
Historical data were compiled on water quality and water levels for the St. Joseph Bay area to assess quality of possible sources of land-derived water into the Bay. Ground-water quality data were compiled from Florida Department of Environmental Protection and surface-water quality data were compiled from U.S.Geological Survey files. Water-quality and water-level data were measured during two sample collection periods in October 1997 and March 1998 to determine water-quality and discharge rates in St. Joseph Bay under two sets of flow conditions. Measurements in the Bay included water level, temperature, pH, specific conductance, dissolved oxygen, and turbidity. Median pH in water from the surficial, intermediate and Floridan aquifer systems ranged from 4.8 to 7.8, and median specific conductance values were less than 500 microsiemens per centimeter. Median nutrient concentrations-- nitrate plus nitrite, ammonia and phosphorus--in the three aquifers were less than 0.5 milligrams per liter. The median pH was 7.0 and the median specific conductance was 81 microsiemens per centimeter for two samples from the Chipola River distribution canal. Water level data were obtained for several wells near St. Joseph Bay but only two wells yielded sufficient data to plot hydrographs. Measurements in St. Joseph Bay during the October and March collection periods were similar for pH and turbidity but differed for temperature, specific conductance and dissolved oxygen. The median temperature was 20.6 degrees Celsius in October and 15.4 degrees Celsius in March, median specific conductance was 39,500 microsiemens per centimeter in October and 43,300 microsiemens per centimeter in March, and median dissolved oxygen was 7.6 milligrams per liter in October and 8.3 milligrams per liter in March. The range in water levels over a tidal cycle in St. Joseph Bay on October 29, 1997 was about 1 foot. During a 24-hour tidal cycle on October 29, 1997, estimated hourly discharge varied from about -116,000 cubic feet per second (ft3/s) (into the Bay) to about +110,000 ft3/s (out of the Bay). During a 24-hour tidal cycle on March 3, 1998, the water level change was about 1.3 feet and estimated hourly discharge varied from about -132,000 ft3/s (into the Bay) to about +121,000 ft3/s (out of the Bay).
Neurological problems of famous musicians: the classical genre.
Newmark, Jonathan
2009-08-01
Neurological histories of great musicians allow for a unique perspective on music physiology. Bedrich Smetana's autobiographical string quartet ends with the musical equivalent of tinnitus in the fourth movement, rendering the youthful and passionate themes of earlier movements moot as the piece ends depicting his ultimately fatal disease, neurosyphilis. Dmitri Shostakovich survived the censorship of Joseph Stalin's apparatchiks but suffered a prolonged form of paralysis attributable to slowly progressive motor neuron disease, although the viola sonata he wrote on his deathbed has become standard repertoire. Glenn Gould was a hypochondriacal pianist with obsessive-compulsive disorder and suspected Asperger syndrome. Vissarion Shebalin and (Ira) Randall Thompson had strokes followed by aphasia without amusia. Domenico Scarlatti provides an example of how even great composers must alter their technical expectations depending upon the skills and body habitus of their chief patrons. The focal dystonia afflicting Leon Fleisher and Gary Graffman catalyzed the discipline of performing arts medicine.
2014-11-01
the time of Napoleon ???s actions in Spain. At the conclusion of the research, the key findings were of no surprise. Napoleon , King Joseph Bonaparte ...were of no surprise. Napoleon , King Joseph Bonaparte , and his commanders in the field failed to grasp the sociocultural issues motivating the...exile on St. Helena, Napoleon Bonaparte contemplated on how he came to be on this remote island in the Atlantic Ocean after dominating all of Europe
Summary of Results, Chief Joseph Dam Cultural Resources Project, Washington.
1985-01-01
Cmpbll, . R S*CONTRACT OR GRANT NUMUER(a) S. ambeled. with V.CazoR Dalai" P. Davis, D. Hibbert, S. Key, L.L. and L.A. Leeds, DACW67-78-C-0106 -: E ...Leopold, E . Lohse, S. Livingston, C. Miss, R. Nickmann. L. Salo, 0. Sammons-Lohse, (cont.) ~.s SPERFORMING ORGANIZATION NAME AND0 ADDRESS 10...Dat Eneed V 7 •,- "Mop-, e ~~l . - , ., - . W~PY OF REStALTS. 041 EF JOSEPH DAN CUtlJRAL RESOURCES PROECT, WASHINGTON edited by Sarah K. Campbell
Sen. Coons, Christopher A. [D-DE
2012-03-21
Senate - 08/02/2012 Resolution agreed to in Senate with an amendment and an amendment to the Title and an amended preamble by Unanimous Consent. (All Actions) Tracker: This bill has the status Agreed to in SenateHere are the steps for Status of Legislation:
Internment and ministry: A dialogue with Joseph Kitagawa.
Moss, D M
1993-09-01
This dialogue presents a profile of the late Joseph Kitagawa-a renowned scholar of the history of religions (Religionswissenschaft). It focuses on comparative religion and philosophy, as well as several other important issues related to his distinguished career as an Episcopal priest and dean of the Divinity School of the University of Chicago. They are: his experience of American concentration camps during World War II; Christian atheism and new theological models; concepts of time in Oriental and Occidental faiths; depth-psychology and contemporary ministry; and Paul Tillich's significance for the pastoral counseling movement.
Professor Joseph Warren Horton (1889-1967): biological engineer.
Zeitlin, Gerald L
2005-02-01
Joseph Warren Horton graduated with a degree in electrical engineering from the Massachusetts Institute of Technology (MIT) in 1914. He became involved in the early development of electrical measurement devices, televised image transmission, and the detection of underwater sound transmission. In the mid-1930s he was appointed the first leader of the newly created Department of Biological Engineering at MIT and in this position he made major contributions to the application of physics to human physiology, in particular by increasing the safety of explosive inhalational anaesthetic agents.
The Effect of Moisture on Carbon Fiber Reinforced Epoxy Composites. 1. Diffusion
1976-09-27
II i NSWC/WOL/’r 76-7 0 00 WHITE OAK LABORATORY THE EFFECT OF MOISTURE ON CARBON FIBER REINFORCED EPOXY COMPOSITES I DIFFUSION 0 BY Joseph M. AugI 27...Effect of Moisture on Carbon Fiber’ Reinorcd EoxyComposites. onZI j , l Joseph M./Augll - lan E./egr ,. E RORMING ORGANIZATION NAME AND ADDRESS 10...Diffusion Carbon fiber composite* 20. A bf AACT (Ceedhlua on rverse side it meosemp &W idmtl’ 5 bl eek mmbeet) Mathematical models are suggested for
2003-10-21
KENNEDY SPACE CENTER, FLA. - In the Space Station Processing Facility, workers (in protective clothing) brief STS-117 Mission Specialist James Reilly (center) and STS-115 Mission Specialist Joseph Tanner (right) about the Japanese Experiment Module (JEM). Equipment familiarization is a routine part of astronaut training and launch preparations.
Advanced Composite Air Frame Life Cycle Cost Estimating
2014-06-19
Kilic, H., et al x Klumpp, Joseph J. x Koury, Jennifer x Kutner, M.,et al Lambert , Daniel x x x x x x x x x x x x x x x Methodology Areas...Joseph J. x x x x x x x Koury, Jennifer x Kutner, M.,et al x x x x x x x x Lambert , Daniel x x x x x x...Company, Houston, TX., 1996. 5. Beer , F., and E. Jr. Johnston. Mechanics of Materials. McGraw-Hill. New York, 1981. 6. Bock, D. Cost Effectiveness
Inpatient Psychiatric Admission Rates in a U.S. Air Force Basic Military Training Population
2017-05-20
PRESENTATION. 18 . AUTHOR’S PRINTED NAME, RANK, GRADE 19. AUTHOR’S SIGNATURE Joseph A . Mansfield, CPT, 0-3 f.W4SFIELD JOSEPH AU>H 1050007,,.0...7141 for email instructions. 30 March 2017 17187 26. DATE REVIEWED 27. DATE FORWARDED TO 502 ISG/JAC A pril 18 , 2017 28. AUTHOR CONTACTED FOR...1086667270 ::.!!:: .. ~ -"’"’ -· A pril 18 , 2017 2nd ENDORSEMENT 1502 ISG/JAC Use Only) 33. DATE RECEIVED 34. DATE FORWARDED TO 59 MOW/PA 35
Johann Joseph Oppel (1855) on Geometrical–Optical Illusions: A Translation and Commentary
Todorović, Dejan; Phillips, David; Lingelbach, Bernd
2017-01-01
The term geometrical–optical illusions was coined by Johann Joseph Oppel (1815–1894) in 1855 in order to distinguish spatial distortions of size and orientation from the broader illusions of the senses. We present a translation of Oppel’s article and a commentary on the material described in it. Oppel did much more than give a name to a class of visual spatial distortions. He examined a variety of figures and phenomena that were precursors of later, named illusions, and attempted to quantify and interpret them. PMID:28694957
Ohara, Willian Massaharu; Tencatt, Luiz F C; Britto, Marcelo R
2016-09-26
A new species of Corydoras is described from the upper Rio Machado, Rio Madeira basin, Rondônia State, Brazil. The new species can be distinguished from its congeners by the absence of contact between the posterior process of the parieto-supraoccipital and the nuchal plate; a ventral laminar expansion of the infraorbital 1 conspicuously developed; and the posterior margin of the pectoral-fin spine with serrations along almost of its entire length, only lacking in the distal portion. Additionally, Corydoras hephaestus possesses dorsal and pectoral spines short, and exhibits an unusual color pattern in life. The conservation status of the new species and other endemic species are briefly commented.
Interaction of two cylinders in shear flow at low Wi
NASA Astrophysics Data System (ADS)
Brown, M. J.; Leal, L. G.
2001-11-01
Experiments [Lyon et al., 2001; Boussima et al., 1996; Michelle et al., 1977] have shown that non-Brownian, non-Colloidal, and charge-neutral particles, when suspended in viscoelastic media and subjected to shear, will aggregate and flow-align above a critical shear rate Wi O(10). Giesekus [1978] proposed a mechanism for aggregation based on the attractive hoop thrusts about two particles in viscoelastic flow. This pairwise mechanism of attraction is borne out in studies of sedimenting particles [Feng & Joseph, 1996; Joseph et al., 1994], and seems a valid explanation for the aggregation observed in sedimenting suspensions over all Wi > Re [Joseph et al., 1994; Phillips, 1996.] Consideration of the flow around two particles in shear would lead one to expect attraction by this hoop thrust mechanism as well. However, it remains unclear why shear-induced aggregation only occurs above a critical Wi. A first step in understanding this criticality is to establish the low Wi behavior of two particles in shear. In this talk, we report on the interaction of two freely-mobile cylinders as predicted by an n-th order fluid computation.
Umbilical metastases: current viewpoint
Gabriele, Raimondo; Conte, Marco; Egidi, Federico; Borghese, Mario
2005-01-01
Background Umbilical metastases from a malignant neoplasm, also termed Sister Mary Joseph's nodule, are not commonly reported in the English literature, and they have usually been considered as a sign of a poor prognosis for the patient. The present article reports on the current view point on umbilical metastasis besides discussing the epidemiology, clinical presentation, pathophysiology and treatment. Method A search of Pubmed was carried out using the term 'umblic*' and 'metastases' or metastasis' revealed no references. Another search was made using the term "Sister Joseph's nodule" or sister Joseph nodule" that revealed 99 references. Of these there were 14 review articles, however when the search was limited to English language it yielded only 20 articles. Articles selected from these form the basis of this report along with cross references. Results The primary lesions usually arise from gastrointestinal or genitourinary tract malignancies and may be the presenting symptom or sign of a primary tumour in an unknown site. Conclusion A careful evaluation of all umbilical lesions, including an early biopsy if appropriate, is recommended. Recent studies suggest an aggressive surgical approach combined with chemotherapy for such patients may improve survival. PMID:15723695
The whole is more than the sum of its parts: Aristotle, metaphysical.
Upton, Joseph; Janeka, Ivo; Ferraro, Nalton
2014-01-01
This phrase, a favorite of Dr. Joseph E. Murray, can be interpreted in many ways. Mathematically, the whole is equal to the sum of its parts, neither more nor less. Psychological Gestalt theory would maintain that the whole is something else or something different than the sum of its parts. Merely adding up the component parts is meaningless compared with the "part-whole" relationship (SYNERGETICS: Explorations of Thinking. MacMillan Publishing Co, Inc; 1975). Organizational pundits maintain that this principle describes the synergy, which exists between individuals working together in a cooperative effort. Collectively, they are able to achieve an outcome superior to that of 1 or 2 people working alone. This concept is vintage Joseph E. Murray. He was an integral part of the Peter Bent Brigham team, which transformed the dream of organ transplantation into clinical reality over 50 years ago. Although many advances in medicine are made by the serendipity of a prepared mind making a critical observation (Alexander Fleming and penicillin), individual brilliance (Judah Folkman and angiogenesis), or by technology (magnetic resonance imaging), most are achieved by groups of physicians and scientists working together. All have prepared minds. When the Peter Bent Brigham Hospital physicians and researchers at the Harvard Medical School dedicated all of their energy on solving the problems of end-stage renal disease, their effort was concentrated and primarily regional. Today, this cooperation is global, as communication has been facilitated by the Internet, iPhone, iPad, video conferencing, electronic libraries, and the like.
Vale, J Allister; Scadding, John W
2018-01-01
This paper will review Winston Churchill's severe respiratory illness in March 1886 when he developed pneumonia of the right lung as an 11-year-old boy. Winston was treated supportively with 'nourishment, stimulants [probably alcohol] and close watching' at his school by the 'celebrated' family physician, Dr Robson Roose, with the assistance of Dr Joseph Rutter. Roose was exemplary in his commitment to his young patient and assiduous in informing Lord Randolph Churchill of his son's clinical progress by letter.
TNT Equivalency Testing of Chemical Mixtures in Continuous TNT Manufacturing
1980-08-01
RONALD RAPE JOSEPH MAVEC RICHARD JOYCE IIT RESEARCH INSTITUTE 10 WEST35TH STREET CHICAGO. IL 60616 PAUL PRICE. PROJECT LEADER ARRADCOM. DOVER. NEW...AUTHORfs; Ronald Pape, Joseph Mavec, Richard Joyce, IIT Research Institute Paul Price, Project Leader, ARRADCOM 8. CONTRACT OR GRANT NUMBERfs...r-4 (0 ^ o s •H ^ <U XI 4J C-H •r4 1-1 i-l 1-1 >. a; X) U to •rl U «c U-l o 60 C *J •H C x m^: •^ E c B 4J CC M 4-J 4-1
2003-10-21
KENNEDY SPACE CENTER, FLA. - In the Space Station Processing Facility, STS-115 Mission Specialist Joseph Tanner (left) and STS-117 Mission Specialist James Reilly (right) are donning protective clothing to interface with the Japanese Experiment Module (JEM), in the background. Equipment familiarization is a routine part of astronaut training and launch preparations.
Haridas, Rajesh P
2018-01-01
In the 1870s, Joseph Jacobs was employed as an apprentice in the Longs and Billups pharmacy in Athens, GA. Jacobs later established a chain of pharmacies in Atlanta, GA. Coca-Cola was first sold to the public on May 8, 1886, at Jacobs' Pharmacy in the Five Points district of Atlanta, GA. The soda fountain in Jacobs' Pharmacy was owned by Willis E. Venable, who was related to James M. Venable, the first patient etherized by Crawford Long in Jefferson, GA. Copyright © 2018 Elsevier Inc. All rights reserved.
1981-02-01
wooden structure would be safer than one of stone or brick may have been. The New Madrid earthquake of December 18 11 did hit the middle Mississippi River...Hood 1958: 1; Barker 1927: 389). Joseph Barker’s father, Deacon Ephraim, was a housewright and builder of churches in New Hampshire and also worked as a...of Ohio, the Barker family migrated to the Ohio Valley from New England, specifically from Amherst, New Hampshire, in 1789 (Hood 1958: iii). Barker was
1982-02-08
II 00 CASE STUDIES OF LARGE BUSINESS - SMALL BUSINESS INTERACTION ’C- DTIC. Henry H1. Hitchcock dlELECTE7 Joseph F. Coates Marcy M. Canavan AUGG261982...J wis&omWWS1ARET N W WASIINGTOW. OC NO$I THE CONSEQUENCES OF METRIC PRODUCTION FOR SMALL MANUFACTURERS Volume 11 CASE STUDIES OF LARGE BUSINESS ... SMALL BUSINESS INTERACTION Accesqi~r, For NTIS GRA&t DTIC TAB Unannoun~ced J’htiI’ctof _ Henry H. Hitchcock vi 1ribr i t o aes Joseph F. Coates Avail arid
Astronaut Joseph Tanner checks gloves during during launch/entry training
1994-06-23
S94-40082 (23 June 1994) --- Astronaut Joseph R. Tanner, mission specialist, checks his glove during a rehearsal for launch and entry phases of the scheduled November flight of STS-66. This rehearsal, held in the Crew Compartment Trainer (CCT) of the Johnson Space Center's (JSC) Shuttle Mockup and Integration Laboratory, was followed by a training session on emergency egress procedures. In November, Tanner will join four other NASA astronauts and a European mission specialist for a week and a half aboard the Space Shuttle Atlantis in Earth-orbit in support of the Atmospheric Laboratory for Applications and Science (ATLAS-3).
Wilson, Caroline
2010-12-01
The state of Kerala, south India, has particularly high prevalence rates for cardiovascular disease (20%, Sugathan, Soman and Sankaranarayanan 2008) and Type II diabetes (16.3%, Kutty, Joseph, and Soman 1999). Although so-called 'lifestyle' diseases can be prevented and symptoms controlled by diet, exercise, and medicines, heart disease and diabetes have become the most common causes of suffering, disability and death. This article explores the social dynamics transforming consumer lifestyles as increased food consumption, reduced physical activity and social stress contribute to the burden of cardiovascular disease (CVD). It examines the centrality of food to ideas of the 'good life', to nurture social relationships and strengthen weak modern bodies, as the principle source of embodied pleasure and health. It explores the micro and macro politics of eating and feasting, limiting the extent to which 'individuals' (can) control food habits. Thus, despite widespread recognition of the relationship between diet, exercise and heart disease, the flow of food, the immediacy of pleasure, and associations between appetite and health override latent concerns about the negative impacts of dietary excesses on long-term health and chronic illness. Findings are discussed to highlight the inherent limitations of public health interventions focusing on education and individual choice.
[Joseph Toynbee--otologist, scientist, philanthropist].
Betlejewski, Stanisław; Betlejewski, Andrzej
2009-01-01
Joseph Tonbee's life's work may be summarized in the words of William Wilde: "The labours and investigations of Mr. Toynbee have affected more for aural pathology than those of all his predecessors either in England or on the continent". Some idea of the extent of his researches is given by the fact that he dissected some 2.000 ears. These preparations formed the Toynbee Collection in the Museum of the Royal College of Surgeons of England. He wrote the results of his researches in a catalogue that includes the description of 1,659 human ears. This catalogue forms the basis of modern otology for all time. This purely pathological catalogue was completed in 1860 with the publication of a more clinical book, "The Diseases of the Ear: their Nature, Diagnosis and Treatment". Toynbee appears to have been the first to describe the pathological changes in otosclerosis. In his book "Diseases of the Ear" he described the condition clearly, recognizing "anchylosis of the stapes to the fenestra ovalis" in 136 temporal bones. He also aligned the subjective, visual and ausculatory tests for Eustacchian tubal patency which we use today. Adam Politzer wrote: "Toynbee was the first who realized in otology that therapeutic progress depends on the knowledge of anatomy". But Toynbee was also active on other fields. Politzer, in his lecture in Vienna in 1914 said: "Toynbee was as outstanding a savant as he was a philanthropist. In addition to his scientific activity, he considered it a sacred task to dedicate his spare time to the improvement of living and health conditions of the poorer classes." Tragic enough, Toynbee's zeal for clinical experimentation went too far. Seeking to help his patients by devising a treatment to allay their tinnitus, he conceived the idea of introducing a mixture of chloroform and prussic acid into the tympanic cavity by means of Valsalva maneuver. When he made the first trial on July 7, 1866, with himself as a subject, he was found dead on the couch in his consulting room.
NASA Technical Reports Server (NTRS)
Ye, B.; DelGenio, A. D.
1999-01-01
Areally extensive, optically thick anvil clouds associated with mesoscale convective clusters dominate the shortwave cloud forcing in the tropics and provide longwave forcing comparable to that of thin cirrus. Changes in the cover and optical thickness of tropical anvils as climate warms can regulate the sign of cloud feedback. As a prelude to the study of MMCR data from the ARM TWP sites, we analyze ISCCP-derived radiative characteristics of anvils observed in the tropical west Pacific during the TOGA-COARE IOP. Anvils with radius greater than 100 km were identified and tracked from inception to decay using the Machado-Rossow algorithm. Corresponding environmental conditions just prior to the start of the convectove event were diagnosed using the Lin-Johnson objective analysis product. Small clusters (100-200 km radius) are observed to have a broad range of optical thicknesses (10-50), while intermediate optical thickness clusters are observed to range in size from 100 km to almost 1000 km. Large-size clusters appear to be favored by strong pre-storm large scale upward motion throughout the troposphere, moist low-to-midlevel relative humidities, environments with slightly higher CAPE than those for smaller clusters, and strong front-to-rear flow. Optically thick anvils are favored in situations of strong low-level moisture convergence and strong upper-level shear.
Uniting Mandelbrot’s Noah and Joseph Effects in Toy Models of Natural Hazard Time Series
NASA Astrophysics Data System (ADS)
Credgington, D.; Watkins, N. W.; Chapman, S. C.; Rosenberg, S. J.; Sanchez, R.
2009-12-01
The forecasting of extreme events is a highly topical, cross-disciplinary problem. One aspect which is potentially tractable even when the events themselves are stochastic is the probability of a “burst” of a given size and duration, defined as the area between a time series and a constant threshold. Many natural time series depart from the simplest, Brownian, case and in the 1960s Mandelbrot developed the use of fractals to describe these departures. In particular he proposed two kinds of fractal model to capture the way in which natural data is often persistent in time (his “Joseph effect”, common in hydrology and exemplified by fractional Brownian motion) and/or prone to heavy tailed jumps (the “Noah effect”, typical of economic index time series, for which he gave Levy flights as an examplar). Much of the earlier modelling, however, has emphasised one of the Noah and Joseph parameters (the tail exponent mu and one derived from the temporal behaviour such as power spectral beta) at the other one's expense. I will describe work [1] in which we applied a simple self-affine stable model-linear fractional stable motion (LFSM)-which unifies both effects to better describe natural data, in this case from space physics. I will show how we have resolved some contradictions seen in earlier work, where purely Joseph or Noah descriptions had been sought. I will also show recent work [2] using numerical simulations of LFSM and simple analytic scaling arguments to study the problem of the area between a fractional Levy model time series and a threshold. [1] Watkins et al, Space Science Reviews [2005] [2] Watkins et al, Physical Review E [2009
Philp, R B; Leung, F Y; Bradley, C
2003-02-01
Benthic marine invertebrates, sediment, and water from several locations along the Florida panhandle coast from St. Joseph Bay in the west to the mouth of the Wakulla River in the east, including from several river estuaries, were analyzed by double focusing ICP-MS (Finnigan MAT ELEMENT) for Cd, Hg, Pb, Cu, Zn, and As. All were detected in all samples. Sponges generally contained higher levels of Cd than other species. Microciona prolifera sponges from St. Joseph Bay had higher As levels (8.1-13.6 microg/g dry weight) than sponges collected from Dickerson Bay or Appalachee Bay (2.20-9.7) and higher Cd levels (0.43-0.73) than that of a single Microciona specimen collected from Dickerson Bay (0.29). Water content of As was about 20-30x higher in St. Joseph Bay than in any other location, and sediment levels of Cd were about 9x higher. Cu and Zn were higher in organic sediment from St. Joseph Bay than they were in other areas. The Pb content of several sponge species and two of tunicates was considerably higher than in other species. The uptake of most metals in this study (except As) appeared to be affected by the metal, genus, species, and location as much as by levels in either water or sediment. In general, sponges and tunicates seemed to accumulate higher levels than most other species, possibly a function of high filtration rates. The ICP-MS method is useful for environmental studies, but the instrument requires considerable maintenance.
Andújar, Carmelo; Hernando, Carles; Ribera, Ignacio
2011-01-01
Abstract A new species of the genus Parazuphium (Coleoptera, Carabidae, Zuphiini), Parazuphium aguilerai sp. n., is described from the Tingitan peninsula in North Morocco. The only known specimen was found under a large deeply buried boulder, and belongs to an anophthalmous, depigmented and flattened species. This is the second species of blind Parazuphium known so far, the other being Parazuphium feloi Machado 1998 from a lava tube in the Canary Islands. Molecular data of the only known Parazuphium aguilerai sp. n. specimen are provided, and a reconstructed phylogeny based on these molecular data confirms its inclusion inside Zuphiini within Harpalinae. Identification keys to the Mediterranean and Macaronesian species of Parazuphium are provided. PMID:21747680
Watson, Caroline C; Griessenauer, Christoph J; Loukas, Marios; Blount, Jeffrey P; Tubbs, R Shane
2013-11-01
William Watson Cheyne lived and trained during a period of great advances in medical knowledge and surgical techniques. Despite his various contributions to the fields of bacteriology and surgery, little is known about his career or his life apart from his affiliations with Joseph Lister. This article aims to identify Cheyne as a pioneer in the treatment of congenital hydrocephalus and sheds light on the man who existed in Lister's shadow for most of his life. Cheyne's technique for surgical intervention of hydrocephalus was a great turning point and contributes to the current treatment strategy utilized today for hydrocephalus.
The Forgotten Forefather: Joseph James Kinyoun and the Founding of the National Institutes of Health
Morens, David M.; Fauci, Anthony S.
2012-01-01
ABSTRACT In celebrating the 125th anniversary of the National Institutes of Health (NIH) in August 2012, NIH has been examining its origins, its history, and the visionary men and women whose research have contributed to the saving and/or improving the quality of life of millions of people throughout the world. This minireview examines Joseph James Kinyoun (1860 to 1919), the 1887 founder of a federal Hygienic Laboratory that is considered the direct ancestor of the modern NIH, and explores the development of NIH as it was shaped by, and in turn shaped, the new field of microbiology. PMID:22736540
Olry, Régis
2005-06-01
Catholic priest Fiacre-Joseph of Goy, born in the Auvergne, was imprisoned in Les Carmes at the end of August 1792. On September 2, during the September massacres, he was thought to have been killed and was taken to the Vaugirard cemetery, where the carter realized that he was only severely injured. Miraculously saved from the massacres, de Goy then became a dental surgeon. Under the Directoire, he resumed his ecclesiastical career, acquiring from the member of the National Convention, Merlin de Thionville, the Mont-Valérien monastery, where he died on February 19, 1806.
Li-Fraumeni syndrome: Discovery and future challenges - Joseph Fraumeni Symposium
In May 2014, NCI’s Division of Cancer Epidemiology and Genetics (DCEG) hosted Cancer Epidemiology: From Pedigrees to Populations, a scientific symposium honoring 50 years of visionary leadership by Dr. Joseph F. Fraumeni, Jr., the founding Director of DCEG. In this video, Dr. Stephen Chanock of NCI provides opening remarks. Dr. David Schottenfeld of the University of Michigan moderates a session on the search for cancer susceptibility genes. Dr. Louise Strong of University of Texas MD Anderson Cancer Center speaks about the discovery and future challenges of Li-Fraumeni syndrome research. For more information on this symposium, visit http://dceg.cancer.gov/news-events/Fraumeni-symposium-speakers.
Home range and habitat use of juvenile green turtles (Chelonia mydas) in the northern Gulf of Mexico
Lamont, Margaret M.; Fujisaki, Ikuko; Stephens, Brail S.; Hackett, Caitlin
2015-01-01
Conclusions: Green turtles in St. Joseph Bay have relatively small home ranges and many contain multiple activity centers. The frequent use of channels by turtles suggests bathymetry plays a major role in habitat selection of juvenile green turtles, particularly as temperatures drop in winter. The quality and density of seagrass habitat in St. Joseph Bay and its proximity to deep channels appears to provide ideal conditions for juvenile greens. The results of this study help define characteristics of foraging habitat utilized by juvenile greens in the northern Gulf of Mexico that managers can use in creating protected areas such as aquatic preserves.
Looking at the vintage of 1949
NASA Astrophysics Data System (ADS)
Fifty years ago, as 1949 began, AGU dues had been raised from $5 to $7 per year. James Bernard Macelwane had just received the William Bowie Medal. Walter H. Bucher was about to become president, and H. U-.Sverdrup was vice-president.The Union's 4,500 members could choose among eight sections: Geodesy, Seismology, Meteorology, Terrestrial Magnetism and Electricity, Oceanography, Volcanology Hydrology, and Tectonophysics. Of the approximately 200 new members that joined AGU in 1949, 34 are celebrating 50 years of membership this year.The individuals listed below join the distinguished ranks of the other 50-year members. Their continuing commitment to AGU is deeply appreciated. Stephen E. Blewett, William E. Bonini, William M. Cameron, Robert A. Clark, John C. Cook, Joseph S. Cragwall, Jr., Richard C. Culler, Martin M. Fogel, Joseph B. Franzini, Thomas A. Gleeson, O. Milton Hackett, Arthur FHasbrook, James W. Hood, Shragga Irmay William W. Kellogg, Elizabeth R. King, Howard Klein, Finley B. Laverty Heinz H. Lettau, Kurt E. Lowe, Arthur R. Miller, Joseph W Mixsell, Carlo Morelli, Jack E. Oliver, B. H. Olsson, George L. Pickard, John L. Rosenfeld, Thorndike Saville, Jr., John W. Siegmund, James E. Slosson, John Summersett, Harold A. Thomas, Jr., Charles M. Weiss, and Glenn C. Werth.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Not Available
The 18-acre Joseph Forest Products (JFP) site is a wood-processing facility in the City of Joseph, Wallowa County, Oregon. Land use in the area is predominantly industrial and agricultural. The City of Enterprise uses two springs located 4,000 feet from JFP to serve as its municipal water supply. In 1974, and again from 1977 to 1985, Joseph Forest Products, Inc., used the site as a lumber mill, processing wood into lumber products. The selected remedial action for the site includes demolishing contaminated onsite structures, including the process, storage, and mixing tanks, and the wooden structures and concrete slabs, followed bymore » offsite disposal; decontaminating the concrete drip pad and tanks, followed by recycling or offsite disposal of debris; excavating surface and subsurface soil, with screening and segregation of hazardous waste for offsite disposal, with stabilization, if necessary, prior to disposal at appropriate facilities; backfilling any excavated areas; removing asbestos from the facility, with offsite disposal; removing underground storage tanks and any associated contaminated soil, with scrapping or offsite disposal; monitoring ground water; and implementing institutional controls, including deed and land use restrictions or environmental notices. The estimated capital cost for this remedial action is $550,000, with an annual O M cost of $24,000 for 3 years.« less
The Dark Side of Addiction: The Horsley Gantt to Joseph Brady Connection.
Koob, George F
2017-04-01
W. Horsley Gantt and Joseph V. Brady laid a rich foundation for understanding the concept of emotion, derived from 2 prominent traditions of physiology and psychology: classic conditioning and operant conditioning, respectively. This framework guided my fierce interest in motivation in general and the interaction between reward and stress, which began at John Hopkins with my thesis work under the guidance of Drs. Zoltan Annau, Solomon Synder, and Joseph Brady, among many others. Using the study of the neurobiology of addiction as a framework, I argue that drug addiction not only involves positive reinforcement associated with the rewarding effects of drugs of abuse but also involves another major source of reinforcement, specifically negative reinforcement driven by negative emotional states (termed the "dark side" of addiction). Excessive activation of the brain reward systems leads to antireward or a decrease in the function of normal reward-related neurocircuitry and persistent recruitment of the brain stress systems, both of which may be neurobiologically linked. Understanding the neuroplasticity of the neurocircuitry that comprises the negative reinforcement associated with addiction is a key to understanding negative emotional states in general and their pathophysiology.
Carl Sagan and Joseph Shklovsky: Intelligent Life in the Universe
NASA Astrophysics Data System (ADS)
Kurt, Vladimir
J. S. Shklovsky and Carl Sagan played an outstanding role in modern astronomy. Their names are well known not only to professional astronomers, but also to millions of educated people in many countries, which are interested in modern state of science research. Among these trends of modern science, which are difficult to define, are such problems, as the creation of Solar system, the origin of life on Earth, the evolution of living organisms on Earth from the simplest viruses to Homo Sapiens, the evolution of intelligence and technology. Finally, both outstanding scientists were deeply interested in the problem of SETI (Search Extraterrestrial Intelligence), i.e. search of extraterrestrial civilizations and methods of making contacts with them. And both scientists were high professionals in their fields. Joseph Shklovsky was a theoretical astronomer in all fields of modern astronomy (geophysics and physics of the upper atmosphere of the Earth, Sun and Solar Corona, Interplanetary Medium and Solar Wind, Interstellar Medium, Supernova and their remnants, the Galaxy and galaxies, Quasars and Cosmology). There is hardly a field in modern astrophysics (except perhaps the theory of the interior structure of stars), where Joseph Shklovsky has not l a bright stamp of his talent…
Hardiman, Jill M.; Breyta, Rachel B.; Haskell, Craig A.; Ostberg, Carl O.; Hatten, James R.; Connolly, Patrick J.
2017-09-12
The Upper Columbia United Tribes (UCUT; Spokane, Colville, Kootenai, Coeur d’Alene, and Kalispel Tribes) and Washington Department of Fish and Wildlife want to reintroduce anadromous salmonids to their historical range to restore ecosystem function and lost cultural and spiritual relationships in the upper Columbia River, northeastern Washington. The UCUT contracted with the U.S. Geological Survey to assess risks to resident taxa (existing fish populations in the reintroduction area upstream of Chief Joseph and Grand Coulee Dams) and reintroduced salmon associated with reintroduction. We developed a risk assessment framework for reintroduction of anadromous salmonids upstream of Chief Joseph and Grand Coulee Dams. To accomplish this goal, we applied strategies identified in previous risk assessment frameworks for reintroduction. The risk assessment is an initial step towards an anadromous reintroduction strategy. An initial list of potential donor sources for reintroduction species was developed from previous published sources for Chinook Salmon (Oncorhynchus tshawytscha) donors in the Transboundary Reach of the Columbia River, British Columbia; an ecological risk assessment of upper Columbia River hatchery programs on non-target taxa of concern; and a review of existing hatchery programsDuring two workshops, we further identified and ranked potential donor sources of anadromous Redband Trout (steelhead; O. mykiss), Chinook Salmon, Sockeye Salmon (O. nerka), and Coho Salmon (O. kisutch). We also identified resident fish populations of interest and their primary habitat, location, status, and pathogen concerns to determine the potential risks of reintroduction. Species were deemed of interest based on resource management and potential interactions (that is, genetics, competition, and predation) with introduced species. We developed tables of potential donors by species and characterized potential sources (hatchery and natural origins), populations (individual runs), broodstock management and history, and potential constraints (that is, Endangered Species Act [ESA] listing, Evolutionarily Significant Unit concerns, pathogens, and availability). During the workshops, a group of regional fisheries and topic experts subjectively ranked the relative risks of pathogens, genetic effects, predation, and competition to resident fish and reintroduced salmonids. We assessed the pathogen risk of each potential donor for introducing new pathogens and the increased burden to existing pathogens for resident species upstream of the dams. We considered genetic risks to resident and downstream conspecifics and ecological impacts, including competition for food and space, predator-prey interactions, and ecosystem benefits/impacts. Each reintroduced species donor source was ranked based on abundance/viability (demographic risk to source and feasibility of collection), ancestral/genetic similarity (evolutionary similarity to historical populations), local adaptation (geographic proximity/similarity of source conditions to reintroduction conditions), and life history compatibility (including migration; spawn timing; and relative usage of reservoir, main-stem, or tributary habitats) with environmental conditions in the reintroduction area. We synthesized this information by species for all potential donors, in which an overall score and ranking system was established for decision support in donor selection for reintroduction into the upper Columbia River. We also provided information outside the ranking process by:Identifying predator-prey interactions and competition for food and space among species,Developing a decision support framework for donor selection, andProviding decision support for reintroduction strategies.
CUP: contraceptive users pamphlet.
1986-02-01
This pamphlet, edited by an ad hoc committee of several consultants, scientists, theologians, public health and family planning directors, and an international attorney, covers the following topics: contra-conception; choices of contraceptives; contraceptive package information; copper IUDs; pelvic inflammatory disease (PID); sexually transmitted diseases; and acquired immunodeficiency syndrome. It includes a questionnaire for sexually transmitted diseases (STDs). Professor Joseph Goldzieher describes the "Contra-Conception" database as "a synthesis of up-to-date literature and contemporary guidelines, designed to provide ready access for practicing physicians and medical students." It contains data on several types of hormonal contraception. "Contra-Conceptions" is designed to allow the physician to set his or her own pace when working with the computer, and no previous computer experience is required. 1 of the program's many innovative features is the patient-profiling/decisionmaking section which can be used in the doctor's office to help decide what type of hormonal contraceptive is appropriate for a particular patient. The program permits the doctor to evaluate the significance of patient variables such as parity, smoking, menstrual difficulties and helps the doctor to identify the risks and benefits of the various methods and, ultimately, to make a balanced decision in the context of the most recent data. Contraceptive drugs and devices should include detailed information on the following: description of formula or device; indication, usage, and contraindications, clinical pharmacology and toxicology; dose-related risk; pregnancies per 100 women year; and detailed warning. The sequence of major pathophysiological reactions associated with copper IUDs is identified as are special problems of pelvic infections in users of copper IUDs. Those women who use oral contraceptives (OCs) or a barrier method of contraception or whose partners use a condom have a lower frequency of PID than women not employing any protection. It is well established that copper IUDs cause different types and different degrees of PID. Women using copper IUDs are more at risk for pelvic infection. There is a higher frequency of salpingitis and PID when copper IUDs are employed especially when the population is nulligravidas under the age of 25. The pamphlet lists criteria for the diagnosis of salpingo-oophoritis and actue salpingitis.
Agricultural land use and water quality in the upper St. Joseph River basin, Michigan
Cummings, T. Ray
1978-01-01
Land use in the upper St. Joseph River basin of south-central Michigan is primarily agricultural. In the 144-square-mile area, the chemical and physical characteristics of water are determined by the climate and soils, as well as by land conservation practices. Municipal waste discharges affect water quality at some locations, as do the larger lakes and ponds. Data indicate that mean discharge from the basin is 135 cubic feet per second. About half this flow is contributed to the St. Joseph River by three major tributaries: Beebe Creek (36 cubic feet per second); Sand Creek (24 cubic feet per second); and Soap Creek (13 cubic feet per second). Runoff from 21 drainage areas delineated for the investigation ranged from 0.22 to 4.07 cubic feet per second per square mile; both the higher and lower values are largely the result of naturally occurring inter- and intrabasin transfers of water.Suspended-sediment concentrations are low throughout the basin, rarely exceeding 100 milligrams per liter. Mean concentrations at four daily sampling stations on the major tributaries and on the St. Joseph River ranged from 9.7 milligrams per liter to 38 milligrams per liter. The maximum sediment yield was 182 pounds per acre per year. Deposition of sediment in five of the 21 areas resulted in a net loss of sediment transported, and thus “negative” yields.Nitrogen and phosphorus concentrations do not vary greatly from site to site. Mean concentrations of total nitrogen at downstream sites on Beebe, Sand, and Soap Creeks, and on the St. Joseph River ranged from 1.5 to 1.8 milligrams per liter. About 90 percent of all nitrogen, and 66 percent of all phosphorus, is transported in solution. Land used principally for agriculture has a mean total nitrogen yield of 4.9 pounds per acre per year and a mean total phosphorus yield of 0.13 pounds per year. A comparison of total nitrogen and total phosphorus yields with type of agricultural use showed few relationships; nitrogen yield, however, seems to decrease as the percentage of land in row crop and small grain increases. A relation between amount of fertilizer applied to land and the amount in streams could not be demonstrated.Only about 6 percent of the total nitrogen and about 1 percent of the total phosphorus added to the land in animal wastes, in precipitation, and applied as fertilizer, is transported from the basin by the St. Joseph River at Clarendon. Estimates also suggest that almost three times as much nitrogen, and twice as much phosphorus, fall in precipitation on the basin as is transported from the basin by runoff. In general, land conservation practices of the past seem to have been effective in minimizing erosion and leaching of soils in the basin.
Disease management of early childhood caries: results of a pilot quality improvement project.
Ng, Man Wai; Torresyap, Gay; White, Alex; Melvin, Patrice; Graham, Dionne; Kane, Daniel; Scoville, Richard; Ohiomoba, Henry
2012-08-01
The purpose is to report findings of a quality improvement (QI) project implemented at two hospital-based dental clinics that care for children with early childhood caries (ECC). We tested a disease management (DM) approach in children younger than age 60 months with ECC. After 30 months, for the 403 and 234 DM patients at Children's Hospital Boston (CHB) and Saint Joseph Hospital (SJH) who returned for at least two visits, rates of new cavitation, pain, and referrals to the OR were 26.1, 13.4 and 10.9% for CHB and 41.0, 7.3 and 14.9% for SJH. Rates of new cavitation, pain, and referrals to the OR for historical controls were 75.2, 21.7, and 20.9% for CHB and 71.3, 31.3, and 25.0% for SJH. A risk-based DM approach utilizing QI strategies to address ECC can be implemented into practice and has the potential to improve care and health outcomes.
A community-wide media campaign to promote walking in a Missouri town.
Wray, Ricardo J; Jupka, Keri; Ludwig-Bell, Cathy
2005-10-01
Engaging in moderate physical activity for 30 minutes five or more times per week substantially reduces the risk of coronary heart disease, stroke, colon cancer, diabetes, high blood pressure, and obesity, and walking is an easy and accessible way to achieve this goal. A theory-based mass media campaign promoted walking and local community-sponsored wellness initiatives through four types of media (billboard, newspaper, radio, and poster advertisements) in St Joseph, Mo, over 5 months during the summer of 2003. The Walk Missouri campaign was conducted in four phases: 1) formative research, 2) program design and pretesting, 3) implementation, and 4) impact assessment. Using a postcampaign-only, cross-sectional design, a telephone survey (N = 297) was conducted in St Joseph to assess campaign impact. Study outcomes were pro-walking beliefs and behaviors. One in three survey respondents reported seeing or hearing campaign messages on one or more types of media. Reported exposure to the campaign was significantly associated with two of four pro-walking belief scales (social and pleasure benefits) and with one of three community-sponsored activities (participation in a community-sponsored walk) controlling for demographic, health status, and environmental factors. Exposure was also significantly associated with one of three general walking behaviors (number of days per week walking) when controlling for age and health status but not when beliefs were introduced into the model, consistent with an a priori theoretical mechanism: the mediating effect of pro-walking beliefs on the exposure-walking association. These results suggest that a media campaign can enhance the success of community-based efforts to promote pro-walking beliefs and behaviors.
Kirby, K C; Bickel, W K
1995-01-01
We review four articles from JEAB's March 1994 issue celebrating the contributions of Joseph V. Brady. These articles have implications for studying private events and for studying multiple operants. We suggest that regularly including self-reports about private events in behavioral pharmacological research has resulted in an accumulated knowledge that has facilitated examination of interesting relations among self-reports, environmental factors, and other observable behaviors. Methodological lessons that behavioral pharmacologists have learned regarding the study of multiple operants are also relayed. We provide examples of how these lessons could be useful to applied behavior analysts studying nonpharmacological issues. PMID:7706145
Medicine and music: a note on John Hunter (1728-93) and Joseph Haydn (1732-1809).
Fu, Louis
2010-05-01
Joseph Haydn was a central figure in the development and growth of the European classical musical tradition in its transition from the Baroque period. John Hunter as the Founder of Scientific Surgery was a dominant figure in 18th-century British medical science. Anne Hunter née Home (1742-1821) was in her own right a figure of some eminence in the literary circles of 18th-century London. Attracted to the burgeoning medical and musical scenes of London, John Hunter married Anne Home and became a famous surgeon; Haydn became acquainted with the Hunters. The people, the opportunities and the circumstances had coincided.
Paul, Jimmy; Sankaran, Pradeep M; Joseph, Mathew M; Sebastian, Pothalil A
2016-10-28
The orb-weaving spider genus Plebs Joseph & Framenau, 2012 currently has only two representatives in India: Plebs himalayaensis (Tikader, 1975) from the Himalayas and Plebs mitratus (Simon, 1895) from the Nilgiris and Anamudi Shola National Park (World Spider Catalog 2016), both are found in high altitude mountainous habitats (Joseph & Framenau 2012). Both species were known only from females (World Spider Catalog 2016), although Sherriffs (1918, 1919) provided a description of an immature male of P. mitratus. In the present paper, we provide the first description of the adult male of P. mitratus, together with the detailed redescription of its female demonstrating considerable intraspecific variation.
Pierre-Joseph Macquer: Chemistry in the French Enlightenment.
Lehman, Christine
2014-01-01
Despite recent studies of chemistry courses and of academic research at the beginning of the eighteenth century, the perception of chemistry in the French Enlightenment has often been overshadowed by Lavoisier's works. This article proposes three specific case studies selected from Pierre Joseph Macquer's (1718-84) rich career to show the continuous evolution of chemistry throughout the century: medicinal chemistry through the application of the Comte de La Garaye's metallic salt solutions, the emergence of industrial chemistry through a few of Macquer's evaluations at the Bureau du Commerce, and finally communal academic research through the experiments on diamonds using Tschirnhaus's lens. These examples attempt to illustrate the innovative, creative, dynamic, multicultural, and multifaceted chemistry of the Enlightenment.
Mutafchiev, Yasen; Santoro, Mario; Georgiev, Boyko B
2010-07-01
Parachordatortilis n. g. is proposed as a monotypic genus for Parachordatortilis mathevossianae (Petrov & Chertkova, 1950) n. comb. (Spirurida, Acuariidae), previously Dispharynx mathevossianae Petrov & Chertkova, 1950. The new genus can be distinguished from all other acuariid genera by having cordons with a sinistral torsion. Parachordatortilis possesses cordons consisting of two rows of delicate cuticular plates delimiting a longitudinal canal. This pattern of cordon structure suggests that Parachordatortilis is closely related to Dispharynx Railliet, Henry & Sisoff, 1912, Synhimantus Railliet, Henry & Sisoff, 1912 and Chordatortilis Machado de Mendonça & Olivera de Rodrigues, 1985. P. mathevossianae is redescribed on the basis of light and scanning electron microscopical observations of specimens collected from a common kestrel Falco tinnunculus L. in southern Italy.
Franz Joseph Gall and music: the faculty and the bump.
Eling, Paul; Finger, Stanley; Whitaker, Harry
2015-01-01
The traditional story maintains that Franz Joseph Gall's (1758-1828) scientific program began with his observations of schoolmates with bulging eyes and good verbal memories. But his search to understand human nature, in particular individual differences in capacities, passions, and tendencies, can also be traced to other important observations, one being of a young girl with an exceptional talent for music. Rejecting contemporary notions of cognition, Gall concluded that behavior results from the interaction of a limited set of basic faculties, each with its own processes for perception and memory, each with its own territory in both cerebral or cerebellar cortices. Gall identified 27 faculties, one being the sense of tone relations or music. The description of the latter is identical in both his Anatomie et Physiologie and Sur les Fonctions du Cerveau et sur Celles de Chacune de ses Parties, where he provided positive and negative evidences and discussed findings from humans and lower animals, for the faculty. The localization of the cortical faculty for talented musicians, he explained, is demonstrated by a "bump" on each side of the skull just above the angle of the eye; hence, the lower forehead of musicians is broader or squarer than in other individuals. Additionally, differences between singing and nonsinging birds also correlate with cranial features. Gall even brought age, racial, and national differences into the picture. What he wrote about music reveals much about his science and creative thinking. © 2015 Elsevier B.V. All rights reserved.
Sherman-Bien, Sandra A.; Malcarne, Vanessa L.; Roesch, Scott; Varni, James W.; Katz, Ernest R.
2013-01-01
Increasingly, empirical support demonstrates that the built environment may affect the physical and psychosocial well-being of patients, their families, and hospital staff (Beauchemin & Hays, 1996; Rubin, Owens, & Golden, 1998; Sherman, Varni, Ulrich, & Malcarne, 2005; Ulrich, 1991; Varni et al., 2004; Whitehouse et al., 2001). Investigators posit two mechanisms through which the built environment can impact patients: indirectly, by enhancing the quality of care and helping a patient feel more relaxed; and/or directly, by altering the physiological recovery process (Malcolm, 1992). Several literature reviews have been published on the relationship between the hospital built environment and patient outcomes (Joseph, Keller, & Kronick, 2008; Rubin et al., 1998; Sherman, Shepley, & Varni, 2005; Ulrich, Quan, Zimring, Joseph, & Choudhary, 2004). In their 1998 review, Rubin et al. found studies linking environment with a number of health and satisfaction outcomes but little research that had been conducted in a scientifically valid manner. Ulrich et al.'s 2004 review of the role of the physical environment in hospital design identified a number of more rigorously conducted studies, focusing mainly on adult environments and on issues of medical safety and hospital-acquired infection rates. Their conclusions linked environmental features such as noise to an increase in perceived stress and physiological arousal; exposure to natural light to reductions in depression, length of hospital stay, and pain medications and to improved sleep; and hospital gardens to improved physical and psychosocial functioning (Ulrich et al., 2004). PMID:21960191
... In: Azar FM, Beaty JH, Canale ST, eds. Campbell's Operative Orthopaedics . 13th ed. Philadelphia, ... by: Thomas N. Joseph, MD, Private Practice specializing in Orthopaedics, Subspecialty Foot ...
Presenting Digital Archives with Historical GIS: Mapping Joseph Needham's Trips in WWII China
NASA Astrophysics Data System (ADS)
Wu, H.
2017-12-01
Since 2016, select groups of students (aged 14-17) from the Independent School Foundation Academy (ISF), Hong Kong, have been constructing a Historical GIS system for the Needham Research Institute (NRI), Cambridge, UK, during their annual summer school in Cambridge. Students read the diaries and reports of Joseph Needham, the Cambridge scientist who worked in China from 1943 to 1946 as the head of the Sino-British Science Cooperation Office, and mapped out both Needham's itineraries and the location of Chinese scientific institutions he visited. By taking part in this project, students learnt two sets of skills: the historian's skills of reading and analyzing primary sources, and the geographer's skills of creating datasets and maps with a GIS software. This project will be carried on in future years, to gradually include other trips Joseph Needham undertook in China in the second half of the 20th century, thus making an essential contribution to the digitalization and the diffusion of the NRI's archives. As a historical researcher in NRI and an educator, the presenter will offer some reflections on the benefit of historical GIS projects as a venue par excellence for research institutions and schools to join force, enhancing both academic research and teaching with an enlarged social impact.
Augusta Déjerine-Klumpke: the first female neuroanatomist.
Shoja, Mohammadali M; Tubbs, R Shane
2007-08-01
Augusta Déjerine-Klumpke, the wife of Joseph Jules Dejerine, an eminent French neurologist, was an American and the first woman to intern in a Parisian hospital. She is known for Klumpke's radicular palsy, which is a neuropathy involving the lower nerve roots of the brachial plexus. The neuroanatomical treatise that she wrote together with her husband is considered a masterpiece. Klumpke won several awards in medical science, the first of which was in the field of anatomy when she was a student. She was a pioneer of rehabilitation therapy after spinal cord injuries and contributed much to our current knowledge of spinal cord diseases. We review the current English and French literature regarding this neuroanatomist who was the first woman to directly contribute to the writing of a neuroanatomy textbook.
NASA Astrophysics Data System (ADS)
Schneider, Ivo
The relationship between the astronomer von Zach on the one side and the entrepreneur Joseph von Utzschneider and his partner Georg von Reichenbach on the other dates presumably from the year 1807 when Zach spent two months in Munich. Already in the same year Zach had ordered an instrument for himself and began to solicit business for the institute of Reichenbach, Utzschneider, and Liebherr, which was founded in 1804. One of the clients canvassed by Zach was the director of the observatory in Naples Zuccari. Zuccari had ordered the whole equipment for the new observatory from this institute in 1813. The instruments for Naples, which were completed in 1814, were sent accompanied by Reichenbach by land and sea to their destination where Reichenbach supervised their setup. At that time Reichenbach had separated from Utzschneider who kept the optical institute in Benediktbeuern with his new partner Joseph von Fraunhofer whereas Reichenbach became owner of the mathematical-mechanical institute in Munich. For personal and economical reasons Utzschneider began soon after to produce not only optical glass but also optical devices similar to those offered by Reichenbach. As soon as two institutes in Munich competed against each other on the market for sophisticated geodetical and astronomical instruments Zach sided with Utzschneider. Zach's main professional argument for this decision was that both competitors got the optical glass for their instruments from Utzschneider's optical institute in Benediktbeuern. This meant that Utzschneider had first choice and so the optical part of his instruments could be considered as better than that of Reichenbach`s instruments. Zach's role as an agent in Italy and France for the sale of products coming from Utzschneider's manufactories is highlighted by three of Zach's letters to Utzschneider from 1817 and 1818, two of which are reproduced here for the first time.
Using Proteomics to Identify Viral microRNA-Regulated Genes | Center for Cancer Research
Kaposi sarcoma is a soft tissue malignancy that affects the skin, the mucous membranes, the lymph nodes and other organs of individuals with compromised immune systems. It is caused by infection with human herpesvirus-8 also known as Kaposi sarcoma-associated herpesvirus or KSHV. The herpesvirus family is unique in that it is the only viral family currently known to express multiple microRNAs (miRNAs); KSHV produces 12 pre-miRNAs, which are processed into at least 25 mature miRNAs. While their functions are not well understood, these miRNAs may be a way for the virus to alter the host immune response without producing proteins that could be recognized and targeted by the immune system. Joseph Ziegelbauer, Ph.D., in CCR’s HIV and AIDS Malignancy Branch, and his colleagues set out to identify human targets of KSHV miRNAs and to understand their functional importance.
Corring, Deborah J; Whittall, Sandy; MustinPowell, Jill; Jarmain, Sarah; Chapman, Patty; Sussman, Sam
2016-01-01
St. Joseph's Health Care London (hereafter referred to as St. Joseph's) is a publicly funded hospital that has led mental health (MH) service system transformation in south west Ontario following directives from the Health Services Restructuring Commission (HSRC) (Sinclair 2000). This paper documents how provincial policy; HSRC directives; use of change management activities; organizational planning; and partnerships with other hospitals, community agencies and LHINs drove, shaped and accomplished the transformational change. The transformation included divestment of beds and related ambulatory services to four other hospitals, closure of beds and employment services and the construction of two state-of-the-art facilities. This paper documents the tracking of system performance measures and the outcomes that resulted.
NASA Astrophysics Data System (ADS)
Rothenberg, Marc
2016-01-01
Joseph Henry (1797-1878) is best known for his work in electromagnetism and as the first secretary of the Smithsonian Institution. But he was also a pioneer solar physicist, an early advocate of US participation in astrophysics, and a facilitator of international cooperation in astronomy. This paper will briefly trace his role in the development of the US astronomical community from the time he taught astronomy at Princeton in the 1830s through his death, focusing on failed efforts to persuade US astronomers and patrons of astronomy that the best path for US astronomy should be astrophysics. He thought that the US could make a more significant contribution to astronomy science by striking out on a less travelled path rather than competing with the established European observatories.
Acquisition of wood fuel at the Joseph C. McNeil Generating Station
DOE Office of Scientific and Technical Information (OSTI.GOV)
Kropelin, W.
1993-12-31
The Joseph C. McNeil Generating Station is the world`s largest single boiler, municipally-owned, wood-fired electrical generating plant. The 50 megawatt McNeil Station is located in Burlington, Vermont and is owned by several Vermont public and private electric utilities. The operator and majority owner is the City of Burlington Electric Department (BED). Wood fuel procurement for the McNeil Station has been conducted in an environmentally sensitive way. Harvesting is carried out in conformance with a comprehensive wood chip harvesting policy and monitored by professional foresters. Unpredictable levels of Station operation require rigid adherence to a wood storage plan that minimizes themore » risk of over heating and spontaneous combustion of stockpiled fuel.« less
Joseph Needham, CH, FRS, FBA., b. 9 December 1900; d. 24 April 1995. A Sailor's Tribute and a Memoir
NASA Astrophysics Data System (ADS)
Waters, D. W.
Sailors, indeed anyone interested in the development of sailing craft, will be for ever indebted to Joseph Needham. Today they will find with ease literature that describes the origins, characteristics, and development of sailing craft in the various regions of the world; the inter-relationships between natural products, and native hull stuctures and forms, sails' fabrics, shapes, and performance. They can learn, too, that the closestowing anchor, the water-tight bulkhead, the balanced rudder (and other features of the modern efficiency-conscious ship constructor) have all been adapted from the millenniaold, so-long-despised by Westerners, Chinese junk, just as has, late in this twentieth century, the stiffened sail of the modern high-performance yacht.
Astronaut Joseph Tanner is assisted into his EMU during training
1994-08-01
S94-40048 (1 August 1994) --- Astronaut Joseph R. Tanner, mission specialist, is assisted by Boeing suit expert Steve Voyles as he prepares to be submerged in a 25-feet deep pool at the Johnson Space Center's (JSC) Weightless Environment Training Facility (WET-F). Though no extravehicular activity (EVA) is planned for the mission, at least two astronauts are trained to perform tasks that would require a space walk in the event of failure of remote systems. In November, Tanner will join four other NASA astronauts and a European mission specialist for a week and a half in space aboard the Space Shuttle Atlantis. The flight will support the Atmospheric Laboratory for Applications and Science (ATLAS-3) mission.
Joseph Jastrow, the psychology of deception, and the racial economy of observation.
Pettit, Michael
2007-01-01
This article reconstructs the recurring themes in the career of Joseph Jastrow, both inside and outside the laboratory. His psychology of deception provides the bridge between his experimental and popular pursuits. Furthermore, Jastrow's career illustrates the complex ways in which scientific psychology and pragmatist philosophy operated within the constraints of a moral economy deeply marked by notions of "race." Psychological investigations of deception were grafted onto two of the human sciences' leading tools: the evolutionary narrative and the statistical analysis of populations. Such associations abetted the racialization of the acts of deceiving and being deceived. These connections also were used to craft moral lessons about how individuals ought to behave in relationship to the aggregate population and natural selection's endowment.
Johnson, Bruce R.; Derkey, Pamela D.
1998-01-01
Geologic data from the geologic map of the Spokane 1:100,000-scale quadrangle compiled by Joseph (1990) were entered into a geographic information system (GIS) as part of a larger effort to create regional digital geology for the Pacific Northwest. The map area is located in eastern Washington and extends across the state border into western Idaho (Fig. 1). This open-file report describes the methods used to convert the geologic map data into a digital format, documents the file structures, and explains how to download the digital files from the U.S. Geological Survey public access World Wide Web site on the Internet.
Scheftel, Susan
2009-01-01
This paper explores the unique mind of the twentieth- century American artist Joseph Cornell, known for his boxes and collages made with "found" materials. The author interpolates reflections upon Cornell with vignettes from the treatment of a young child, speculating that certain individuals may possess a constellation of vulnerabilities/sensitivities that constitute what is referred to as a "cosmic" sensibility. It is suggested that such an orientation can lead variously to anxieties and separation problems, as well as (or in addition to) intellectual and/or artistic giftedness. The outcome of such dynamics would depend on a complex interplay of temperament, circumstance, and relational attunement.
Sympathetic science: Charles Darwin, Joseph Hooker, and the passions of Victorian naturalists.
Endersby, Jim
2009-01-01
This essay examines the complex tangle of emotional and scientific attachments that linked Darwin and botanist Joseph Dalton Hooker. Analyzing their roles as husbands, fathers, and novel readers demonstrates that possessing and expressing sympathy was as important for Victorian naturalists as it was for Victorian husbands. Sympathy was a scientific skill that Victorian naturalists regarded as necessary to fully understand the living world; although sympathy became increasingly gendered as feminine over the course of the century, its importance to male naturalists requires us to rethink the ways gender roles were negotiated in Victorian Britain. Botany was, for men like Darwin and Hooker, an acceptably masculine pursuit that nevertheless allowed--and even required--them to be sensitive and sympathetic.
33 CFR 162.120 - Harbors on Lake Michigan.
Code of Federal Regulations, 2010 CFR
2010-07-01
... City, Indiana; St. Joseph, South Haven, Saugatuck, Holland (Lake Macatawa), Grand Haven, Muskegon... of Menominee, Michigan and Wisconsin; Algoma, Kewaunee, Two Rivers, Manitowac, Sheboygan, Port...
77 FR 16316 - Kentucky Disaster Number KY-00044
Federal Register 2010, 2011, 2012, 2013, 2014
2012-03-20
... Counties: (Physical Damage and Economic Injury Loans): Bath, Campbell, Carroll, Grant, Martin, Montgomery... Assistance Numbers 59002 and 59008) Joseph P. Loddo, Acting Associate Administrator for Disaster Assistance...
DOE Office of Scientific and Technical Information (OSTI.GOV)
None
Oberlin College’s Adam Joseph Lewis Center for Environmental Studies is a high-performance building featuring an expansive photovoltaic system and a closed-loop groundwater heat pump system. Designers incorporated energy-efficient components and materials
Ahern, Catherine; McKinnon, Margaret C; Bieling, Peter J; McNeely, Heather; Langstaff, Karen
2016-01-01
Conducting high-quality design research in a mental health setting presents significant challenges, limiting the availability of high-quality evidence to support design decisions for built environments. Here, we outline key approaches to overcoming these challenges. In conducting a rigorous post-occupancy evaluation of a newly built mental health and addictions facility, St. Joseph's Healthcare, Hamilton, we identified a number of systematic barriers associated with conducting design research in mental health settings. Our approach to overcoming these barriers relied heavily upon (i) selecting established measures and methods with demonstrated efficacy in a mental health context, (ii) navigating institutional protocols designed to protect vulnerable members of this population, and (iii) designing innovative data collection strategies to increase participation in research by individuals with mental illness. Each of these approaches drew heavily on the expert knowledge of mental health settings and the experiences with mental health, facilities management, and research of a research team that was well integrated within the parent institution. Engaging multiple stakeholders (e.g., care providers, patients, ethics board, and hospital administrators) contributed their trust and support of the research. Traditionally, post-occupancy evaluation researchers are independent of the facilities they research, yet this is not an effective approach in mental health settings. We found that, in working toward solutions to the three obstacles we described, having team members who were well "networked" within the parent institution was necessary. This approach can turn "gatekeepers" into champions for patients' engagement in the research, which is essential in generating high-quality evidence. © The Author(s) 2015.
Benmoussa, Nadia; Kerner, Jennifer; Josset, Patrice; Conan, Patrick; Charlier, Philippe
2017-01-01
Joseph Gensoul was a pioneer of ENT surgery. In 1827, he performed the first total maxillectomy on 17-year-old boy. His work inspired many surgeons, who were previously unwilling to remove maxillary tumours. A paleopathological study performed in the Dupuytren museum allowed us to identify a skull from the early 19th century, with a large maxillar tumour. There were indications that this skull was operated according to Gensoul's technique. The aim of this study is to confirm that this patient had, in fact, received this surgical treatment. This is a historical and descriptive paleopathological study of a skull of the early 19th century of Dupuytren Museum in Paris. The historical research was conducted in collaboration with the French Academy of Medicine and the Museum of Medicine History (Paris). Bones mark cut studies allowed us to confirm that the patient was operated according to the method described by Gensoul in his "Surgical letter" in 1833. Our historical research has allowed us to understand the perspectives of surgeons in the 19th century and the intellectual processes that led to this discovery. At a time when the robotization and industrialization dominate our art, it is interesting to look to our past, our origins, and our history. The study of ancient humans remains and allows us to understand the origin of our specialty and pay tribute to these pioneering surgeons. Their intellectual approach and boldness should be acknowledged and applauded, especially as it is also the key to our success.
Presidential Green Chemistry Challenge: 1997 Academic Award
Presidential Green Chemistry Challenge 1997 award winner, Professor Joseph M. DeSimone, developed surfactants that allow carbon dioxide to be a solvent for chemical manufacturing, replacing hazardous chemical solvents.
3. Historic American Buildings Survey J. Alexander, Photographer, 1971 DETAIL, ...
3. Historic American Buildings Survey J. Alexander, Photographer, 1971 DETAIL, ENTRANCE STOOP (LION FIGURE) - Joseph Beale House, 2301 Massachusetts Avenue, Northwest, Washington, District of Columbia, DC
Colorado Scientists Win National Award
environmentally friendly products, such as biodegradable pesticides and gasoline additives. Dr. Joseph Bozell and manufacture biodegradable herbicides and pesticides and an oxygenate for cleaner burning gasoline. Biomass
Seven Democratic Presidential Candidates Debate Educational Issues.
ERIC Educational Resources Information Center
Equity and Excellence, 1988
1988-01-01
Provides the transcript of a debate on educational issues among Democratic presidential candidates Paul Simon, Albert Gore, Joseph Biden, Jesse Jackson, Bruce Babbitt, Richard Gephart, and Michael Dukakis. (BJV)
Joseph McCabe: A Forgotten Early Populariser of Science and Defender of Evolution
NASA Astrophysics Data System (ADS)
Cooke, Bill
2010-05-01
Joseph McCabe (1867-1955) was one of the most prolific and gifted polymaths of the twentieth century. Long before such a thing was thought respectable, and almost a century before any university established a chair in the public understanding of science, McCabe made a living as a populariser of science and a critic of philosophical and religious obscurantism. Through the first half of the twentieth century he wrote countless cheap and widely distributed books and pamphlets for those whose thirst for knowledge exceeded the money or time they could devote to such pursuits. This article will detail, and give some assessment of, McCabe’s career as a populariser of science and expositor of evolutionary theory and its philosophical, religious and cultural ramifications.
NASA Astrophysics Data System (ADS)
Kochańska, Agnieszka
2016-09-01
The romantic landscape park was established in 1824 by order of one of the best-known aristocrats at the time, Princess Dorothea Talleyrand Perigold, Dutchess of Dino. The park is an example of amenity horticulture of artistic value that has survived to this day. The creator of the park was the talented landscape architect Peter Joseph Lenné. In its current state, the park differs significantly from the image on lithographs of the past. Upon carrying out field investigations and comparative studies, it was established that the maintained stand of tress holds high compositional value. The conclusions of the article define the current threats to the longevity of the park as well as highlighting the plan of revalorization works.
Joseph Rotblat: Moral Dilemmas and the Manhattan Project
NASA Astrophysics Data System (ADS)
Veys, Lucy
2013-12-01
John Fitzgerald Kennedy famously said, "One man can make a difference and every man should try."1 Joseph Rotblat (1908-2005) was the quintessence of Kennedy's conviction. He was the only scientist who left Los Alamos after it transpired that the atomic bomb being developed there was intended for use against adversaries other than Nazi Germany. I explore Rotblat's early research in Warsaw and Liverpool, which established his reputation as a highly capable experimental physicist, and which led him to join the Manhattan Project at Los Alamos in 1944. I examine his motivation for resigning from the project in 1945, and the unwillingness of his fellow scientists to follow suit, which draws attention to the continuing discourse on the responsibility of scientists for the consequences of their research.
78 FR 23225 - Endangered Species; File Nos. 14759-01 and 16375-01
Federal Register 2010, 2011, 2012, 2013, 2014
2013-04-18
... brevirostrum) and Atlantic sturgeon (Acipenser oxyrinchus oxyrinchus) for purposes of scientific research... Wildlife Research Unit, North Carolina State University, Raleigh, NC 27695 [Joseph Hightower: Responsible...
1989-09-22
In Joseph Palca's News & Comment article "New round in Dingell v. NIH" (28 July, p. 349), the Baylor College of Medicine in Houston, Texas, was incorrectly referred to as "Baylor University." Baylor University is in Waco, Texas.
Certification in "The Basics" One Hundred Years Ago
ERIC Educational Resources Information Center
Velz, John W.
1977-01-01
Quotes from the letters of Joseph Crosby regarding the certification of teachers in English grammar, orthography, arithmetic, and geography in 1877, and reproduces the four certification examinations Crosby developed. (DD)
A web-based tool for the Comprehensive Unit-based Safety Program (CUSP).
Pronovost, Peter J; King, Jay; Holzmueller, Christine G; Sawyer, Melinda; Bivens, Shauna; Michael, Michelle; Haig, Kathy; Paine, Lori; Moore, Dana; Miller, Marlene
2006-03-01
An organization's ability to change is driven by its culture, which in turn has a significant impact on safety. The six-step Comprehensive Unit-Based Safety Program (CUSP) is intended to improve local culture and safety. A Web-based project management tool for CUSP was developed and then pilot tested at two hospitals. HOW ECUSP WORKS: Once a patient safety concern is identified (step 3), a unit-level interdisciplinary safety committee determines issue criticality and starts up the projects (step 4), which are managed using project management tools within eCUSP (step 5). On a project's completion, the results are disseminated through a shared story (step 6). OSF St. Joseph's Medical Center-The Medical Birthing Center (Bloomington, Illinois), identified 11 safety issues, implemented 11 projects, and created 9 shared stories--including one for its Armband Project. The Johns Hopkins Hospital (Baltimore) Medical Progressive Care (MPC4) Unit identified 5 safety issues and implemented 4 ongoing projects, including the intravenous (IV) Tubing Compliance Project. The eCUSP tool's success depends on an organizational commitment to creating a culture of safety.
78 FR 59359 - Ocean Transportation Intermediary License Applicants
Federal Register 2010, 2011, 2012, 2013, 2014
2013-09-26
... (QI), Gregory M. Hinton, Operating Manager, Application Type: QI Change. Safe Movers, Inc. dba Isaac's..., Treasurer (QI), Ami Joseph, President, Application Type: Change Trade Name to Isaac's Moving & Storage. U.S...
75 FR 28492 - Suspension of Community Eligibility
Federal Register 2010, 2011, 2012, 2013, 2014
2010-05-21
... Special Flood Hazard Areas (SFHAs) in these communities by publishing a Flood Insurance Rate Map (FIRM... Do. Joseph County. Emerg; December 15, 1990, Reg; June 4, 2010, Susp. White Pigeon, Village of...
8. Historic American Buildings Survey Verlin Berry, Photographer November 10, ...
8. Historic American Buildings Survey Verlin Berry, Photographer November 10, 1977 FIRST FLOOR, DETAIL OF PRESSED TIN CEILING - 111 West First Street (Commercial Building), Mishawaka, St. Joseph County, IN
75 FR 70299 - Appointments of Individuals To Serve as Members of Performance Review Boards
Federal Register 2010, 2011, 2012, 2013, 2014
2010-11-17
... Counsel, Division of Advice. Richard A. Siegel--Associate General Counsel, Division of Operations Management. Gloria Joseph--Director of Administration, Division of Administration. John H. Ferguson...
Cancer Data and Statistics Tools
... Joseph Jacqueline W. Miller Mona Saraiya Judith Lee Smith Sherri L. Stewart Mary C. White Debra Younginer ... MD, MPH Simple Singh, MD, MPH Judith Lee Smith, PhD Sherri L. Stewart, PhD Eric Tai, MD, ...
4. Historic American Buildings Survey Alex Bush, Photographer, March 24, ...
4. Historic American Buildings Survey Alex Bush, Photographer, March 24, 1937 REAR (WEST) AND NORTH SIDE - Colonel Joseph R. Hawthorne House, Broad Street (County Road 59), Pine Apple, Wilcox County, AL
18. Historic American Buildings Survey Alex Bush, Photographer, March 24, ...
18. Historic American Buildings Survey Alex Bush, Photographer, March 24, 1937 SERVANT'S HOUSE AND GARAGE - Colonel Joseph R. Hawthorne House, Broad Street (County Road 59), Pine Apple, Wilcox County, AL
12. Historic American Buildings Survey Alex Bush, Photographer, March 24, ...
12. Historic American Buildings Survey Alex Bush, Photographer, March 24, 1937 CLOSE-UP OF MAIN ENTRANCE - Colonel Joseph R. Hawthorne House, Broad Street (County Road 59), Pine Apple, Wilcox County, AL
2. Historic American Buildings Survey Alex Bush, Photographer, March 24, ...
2. Historic American Buildings Survey Alex Bush, Photographer, March 24, 1937 FRONT (EAST) AND SOUTH ELEVATION - Colonel Joseph R. Hawthorne House, Broad Street (County Road 59), Pine Apple, Wilcox County, AL
details: window jamb from first period of construction; window jamb, ...
details: window jamb from first period of construction; window jamb, sill profile, and transom profile from second period of construction - Joseph Poffenberger Farm, House, 17834 Mansfield Avenue, Sharpsburg, Washington County, MD
40 CFR 52.776 - Control strategy: Particulate matter.
Code of Federal Regulations, 2010 CFR
2010-07-01
... Approval—The complete Indiana plan for Clark, Dearborn, Dubois, Marion (except for coke batteries), St..., Vandenburgh County; 6-1-17, Clark County; 6-1-18, St. Joseph County; 6-2, Particulate Emissions Limitations...
40 CFR 52.776 - Control strategy: Particulate matter.
Code of Federal Regulations, 2011 CFR
2011-07-01
... Approval—The complete Indiana plan for Clark, Dearborn, Dubois, Marion (except for coke batteries), St..., Vandenburgh County; 6-1-17, Clark County; 6-1-18, St. Joseph County; 6-2, Particulate Emissions Limitations...
133. Photocopy of photograph, 1915 (Chrysler) MAIN BUILDING #1, SECOND ...
133. Photocopy of photograph, 1915 (Chrysler) MAIN BUILDING #1, SECOND FLOOR CHASSIS ASSEMBLY LINE, VIEW SOUTH, 1980 - Dodge Brothers Motor Car Company Plant, Between Joseph Campau & Conant Avenues, Hamtramck, MI
First Arcas Meteorological Rocket
1959-07-31
First Arcas meteorological rocket, shown at Wallops prior to flight test, July 31, 1959. Photograph published in A New Dimension Wallops Island Flight Test Range: The First Fifteen Years by Joseph Shortal. A NASA publication. Page 696.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Not Available
Oberlin Colleges Adam Joseph Lewis Center for Environmental Studies is a high-performance building featuring an expansive photovoltaic system and a closed-loop groundwater heat pump system. Designers incorporated energy-efficient components and materials that are local, non-toxic, and durable.
DOE Office of Scientific and Technical Information (OSTI.GOV)
None
Oberlin College's Adam Joseph Lewis Center for Environmental Studies is a high-performance building featuring an expansive photovoltaic system and a closed-loop groundwater heat pump system. Designers incorporated energy-efficient components and materials that are local, non-toxic, and durable.
NOAA Looks for Advice to Make Its Data Easier to Use
NASA Astrophysics Data System (ADS)
Showstack, Randy
2014-03-01
"There is no sector in American business that wouldn't like to have better environmental information," said Joseph Klimavicz, chief information officer for the National Oceanic and Atmospheric Administration (NOAA).
78. Historic American Buildings Survey, Donald W. Dickensheets, Photographer. March ...
78. Historic American Buildings Survey, Donald W. Dickensheets, Photographer. March 29, 1940. ST. JOSEPH, SACRED HEART. (SOUTH ELEVATION). WEST TRANSEPT - San Xavier del Bac Mission, Mission Road, Tucson, Pima County, AZ
Genetics Home Reference: Timothy syndrome
... on PubMed Splawski I, Timothy KW, Decher N, Kumar P, Sachse FB, Beggs AH, Sanguinetti MC, Keating ... Splawski I, Timothy KW, Sharpe LM, Decher N, Kumar P, Bloise R, Napolitano C, Schwartz PJ, Joseph ...
3. Historic American Buildings Survey George Eisenman, Photographer Summer 1967 ...
3. Historic American Buildings Survey George Eisenman, Photographer Summer 1967 FIRST FLOOR, FRONT ROOM, FIREPLACE IN SOUTHEAST CORNER - Joseph Carleton House, 1052-54 Potomac Street Northwest, Washington, District of Columbia, DC
Pain Relievers: Understanding Your OTC Options
... NSAIDs) There are several types of NSAIDs, including: aspirin (2 brand names: Bayer, St. Joseph) ibuprofen (2 ... muscle sprains). Some products contain both acetaminophen and aspirin (2 brand names: Excedrin, Vanquish). These typically contain ...
Opportunity View of Private Joseph Field on Mars
2016-12-07
This image of a target called "Private Joseph Field" combines four images from the microscopic imager on the robotic arm of NASA's Mars Exploration Rover Opportunity, with enhanced color information added from the rover's panoramic camera. This target is within the "Marathon Valley" area of the western rim of Endeavour Crater. The component images were taken on May 29, 2016, during the 4,389th Martian day, or sol, of Opportunity's work on Mars. The mosaic shows an area spanning about 2 inches (5 centimeters). Geochemical data indicate the presence of magnesium and iron sulfates at this location, most likely corresponding to the white pebble visible near the center of the image. These sulfates may have formed by the interaction of acidic fluids with the rocks along the rim of Endeavour crater. http://photojournal.jpl.nasa.gov/catalog/PIA21142
Thirteen days: Joseph Delboeuf versus Pierre Janet on the nature of hypnotic suggestion.
LeBlanc, André
2004-01-01
The problem of post-hypnotic suggestion was introduced in 1884. Give a hypnotic subject the post-hypnotic command to return in 13 days. Awake, the subject remembers nothing yet nonetheless fulfills the command to return. How then does the subject count 13 days without knowing it? In 1886, Pierre Janet proposed the concept of dissociation as a solution, arguing that a second consciousness kept track of time outside of the subject's main consciousness. Joseph Delboeuf, in 1885, and Hippolyte Bernheim, in 1886, proposed an alternative solution, arguing that subjects occasionally drifted into a hypnotic state in which they were reminded of the suggestion. This article traces the development of these competing solutions and describes some of Delboeuf's final reflections on the problem of simulation and the nature of hypnosis. Copyright 2004 Wiley Periodicals, Inc.
1986-06-20
Bell Richard K. MA C 111 FAB M 20273 Anzini Danniel D. MA C 113 MHAB M 20275 Ariss Bruce F. MA C ABD/HAGS S 20277 Gray Joseph W. MA C AC/1 AC D Fig. 30...John G MA C WC M 03 Arima James J MA C GMB M 05 Ariss Bruce F MA C AS S 04 Armout Paul G MA C 22 HAB M 04 Armstrong David K MA C WC M 04 Arnal Robert J... Ariss Bruce F MA C S AS 05 Gray Joseph W MA C M DAB 05 Jarecki Edward L MA C M ABD/HAGS 05 Harvey Steeve B MA C N DAB 05 Carl Michael S MA C N 22 HAB 05
Silva, Camila de Lima; Graciolli, Gustavo
2013-06-01
Acari ectoparasites were collected from bats during 12 months in the Rio Negro farm (19°34'22″S and 56°14'36″W), Aquidauana, Mato Grosso do Sul. A total of 654 bats belonging to the families Phyllostomidae, Noctilionidae, Molossidae, Vespertilionidae and Emballonuridae were captured. Only 136 bats of nine genera and 11 species were parasitised. Periglischrus iheringi Oudemans was the most abundant mite species, and this prevalence may be related to the low degree of host specificity of this species and due to the broad geographical distribution of its hosts. The greatest mean intensity was found to Periglischrus torrealbai Machado-Allison on Phyllostomus discolor Wagner (Phyllostomidae) and Periglischrus tonatii Herrin and Tipton associated with Lophostoma silviculum d'Orbigny (Phyllostomidae), which also had the highest prevalence of infestation.
Cannabinoids: clearing the smoke on pain, inflammation and neurodegeneration.
Downer, E J; Finn, D P
2014-03-01
This article is part of a themed section on Cannabinoids 2013. To view the other articles in this section, see Fagan and Campbell (2014) DOI: 10.1111/bph.12492, Ignatowska-Jankowska et al. (2014) DOI: 10.1111/bph.12298, Ligresti et al. (2014) DOI: 10.1111/bph.12410, Lopez-Rodriguez et al. (2014) DOI: 10.1111/bph.12519, Murataeva et al. (2014) DOI: 10.1111/bph.12411, Okine et al. (2014) DOI: 10.1111/bph.12540, Rodríguez-Cueto et al. (2014) DOI: 10.1111/bph.12283, Stanley and O'Sullivan (2014) DOI: 10.1111/bph.12560, Toguri et al. (2014) DOI: 10.1111/bph.12545, Wu et al. (2014) DOI: 10.1111/bph.12500. Linked articles are: Avraham et al. (2014) DOI: 10.1111/bph.12478, Machado et al. (2014) DOI: 10.1111/bph.12488, Ward et al. (2014) DOI: 10.1111/bph.12439. © 2014 The British Pharmacological Society.
Ball, C
2010-07-01
The Industrial Revolution saw the creation of many new jobs, but probably none more curious than that of zookeeper. The London Zoological Gardens, established for members in 1828, was opened to the general public in 1847. In 1852 the "Head Keeper in the Serpent Room", Edward Horatio Girling, spent a night farewelling a friend departing for Australia. He arrived at work in an inebriated state and was bitten on the face by a cobra that he was handling in a less than sensible manner. He was taken by cab to University College Hospital where he was resuscitated by a number of doctors, including Joseph Clover then the resident medical officer to the hospital and later to become the leading anaesthetist in London. Clover recorded this event in his diary along with the resuscitation method used. The patient eventually died but his treatment created a flurry of correspondence in the medical and lay press. Interestingly, the attempted resuscitation was with bellows, which had been abandoned by the Royal Humane Society twenty years earlier Clover records other cases of resuscitation with bellows at University College Hospital during his time as a resident medical officer there (1848 to 1853). There is a casebook belonging to Joseph Clover in the Geoffrey Kaye Museum, in Melbourne. This story is one of the many interesting stories uncovered during a study of this book and Clover's other personal papers.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Not Available
1991-09-30
The 5-square-mile Sturgis Municipal Wells site is an active municipal well field in Sturgis, St. Joseph County, Michigan. Land use in the area is predominantly mixed industrial and residential, with several wetlands areas located near the site. The site includes the former Wade Electric facility, which closed in 1966 and burned down in 1974, and the Kirsch Company, which operated as a manufacturing facility until 1980. These two properties have been identified as two source areas responsible for the ground water contamination in the aquifer used for the municipal water supply. State investigations starting in 1982 identified contaminated soil andmore » VOC-contaminated ground water onsite and extensive ground water contamination in various wells throughout the city. The Record of Decision (ROD) addresses final remediation of soil and ground water. The primary contaminants of concern affecting the soil and ground water are VOCs including benzene, PCE, and TCE; and other organics including PAHs.« less
Vergence and Strabismus in Neurodegenerative Disorders
Kang, Sarah L.; Shaikh, Aasef G.; Ghasia, Fatema F.
2018-01-01
Maintaining proper eye alignment is necessary to generate a cohesive visual image. This involves the coordination of complex neural networks, which can become impaired by various neurodegenerative diseases. When the vergence system is affected, this can result in strabismus and disorienting diplopia. While previous studies have detailed the effect of these disorders on other eye movements, such as saccades, relatively little is known about strabismus. Here, we focus on the prevalence, clinical characteristics, and treatment of strabismus and disorders of vergence in Parkinson’s disease, spinocerebellar ataxia, Huntington disease, and multiple system atrophy. We find that vergence abnormalities may be more common in these disorders than previously thought. In Parkinson’s disease, the evidence suggests that strabismus is related to convergence insufficiency; however, it is responsive to dopamine replacement therapy and can, therefore, fluctuate with medication “on” and “off” periods throughout the day. Diplopia is also established as a side effect of deep brain stimulation and is thought to be related to stimulation of the subthalamic nucleus and extraocular motor nucleus among other structures. In regards to the spinocerebellar ataxias, oculomotor symptoms are common in many subtypes, but diplopia is most common in SCA3 also known as Machado–Joseph disease. Ophthalmoplegia and vergence insufficiency have both been implicated in strabismus in these patients, but cannot fully explain the properties of the strabismus, suggesting the involvement of other structures as well. Strabismus has not been reported as a common finding in Huntington disease or atypical parkinsonian syndromes and more studies are needed to determine how these disorders affect binocular alignment.
When and Why Parents Seek Dental Care for Children under 36 Months.
Volpato, Luiz Evaristo Ricci; Palti, Dafna Geller; Lima, Jose Eduardo de Oliveira; Machado, Maria Aparecida de Andrade Moreira; Aranha, Andreza Maria Fabio; Bandeca, Matheus Coelho; Pedro, Fabio Luis Miranda; Borges, Alvaro Henrique
2013-08-01
The aim was to analyze an infant preventive program determining at what age parents take their children for their first dental visit and the reasons why they do it. A total of 844 children aged from 0 to 36 months, enrolled in the program of oral health maintenance of the Baby Clinic, participated in this study. During the first dental visit, the parents were inquired about the reasons that led them to enroll their children in the program. One trained investigator identified this reasons on the records and classified them according to the following scores: orientation/prevention, caries treatment, malpositioned teeth, dental trauma, tooth color alterations and others. Orientation/prevention was the most prevalent reason from 0-6 months to 25-30 months of age, and at the age 30-36 months, the reason caries/treatment overcame orientation/prevention, becoming the most prevalent reason in that age group. The third place was occupied by dental trauma. The mean age parents seek for dental care to their children was 14, 92 months. This study showed a preferentially preventive/educational profile for the children. However, lots of parents still take children to the dentist preferentially for curative instead of preventive treatment. How to cite this article: Volpato LE, Palti DG, Lima JE, Machado MA, Aranha AM, Bandeca MC, Pedro FL, Borges AH. When and Why Parents Seek Dental Care for Children under 36 Months. J Int Oral Health 2013; 5(4):21-25.
Inflammation, suppuration, putrefaction, fermentation: Joseph Lister's microbiology
Richardson, Ruth
2013-01-01
This paper focuses on Lister's inaugural lecture at King's College, London, in October 1877. As the new Professor of Clinical Surgery, Lister had much to report, including impressively high survival rates from complex operations previously regarded as foolhardy. Instead, he chose to address the processes of fermentation in wine, blood and milk. His reasons are not obvious to a modern audience, just as they probably were not to those who heard him in the Great Hall at King's. Having brought microbiological apparatus from his laboratory to the lecture theatre and presented proof of bacterial variety and specificity, Lister publicly demonstrated the creation of the first pure bacterial culture in the history of microbiology. It was an ingenious and well-thought-out strategy designed to generate a frame of mind among his new colleagues and future students, receptive to the causative role of bacteria in septic diseases. His timing was impeccable.
Human Spaceflight Safety Hearing
2009-12-02
Dr. Joseph R. Fragola, Vice President, Valador, Inc., testifies during a hearing before the House Subcommitte on Space and Aeronautics regarding Safety of Human Spaceflight on Capitol Hill, Wednesday, Dec. 2, 2009, in Washington. Photo Credit: (NASA/Bill Ingalls)
STS-115 MS Tanner on Atlantis Middeck
2006-09-10
S115-E-05337 (10 Sept. 2006) --- Astronaut Joseph R. Tanner, STS-115 mission specialist, works on the middeck of the Space Shuttle Atlantis on the eve of docking day with the International Space Station.
7. Historic American Buildings Survey Alex Bush, Photographer, March 24, ...
7. Historic American Buildings Survey Alex Bush, Photographer, March 24, 1937 VIEW INTO LIVING ROOM SHOWING MANTEL - Colonel Joseph R. Hawthorne House, Broad Street (County Road 59), Pine Apple, Wilcox County, AL
8. Historic American Buildings Survey Alex Bush, Photographer, March 24, ...
8. Historic American Buildings Survey Alex Bush, Photographer, March 24, 1937 MANTEL ON SOUTH WALL OF PARLOR - Colonel Joseph R. Hawthorne House, Broad Street (County Road 59), Pine Apple, Wilcox County, AL
16. Historic American Buildings Survey Alex Bush, Photographer, March 24, ...
16. Historic American Buildings Survey Alex Bush, Photographer, March 24, 1937 LOOKING SOUTH WEST AT OLD STABLE - Colonel Joseph R. Hawthorne House, Broad Street (County Road 59), Pine Apple, Wilcox County, AL
6. Historic American Buildings Survey Alex Bush, Photographer, March 24, ...
6. Historic American Buildings Survey Alex Bush, Photographer, March 24, 1937 GENERAL VIEW OF REAR OF MAIN HALL - Colonel Joseph R. Hawthorne House, Broad Street (County Road 59), Pine Apple, Wilcox County, AL
5. Historic American Buildings Survey Alex Bush, Photographer, March 24, ...
5. Historic American Buildings Survey Alex Bush, Photographer, March 24, 1937 FRONT OF ENTRANCE HALL (GENERAL VIEW) - Colonel Joseph R. Hawthorne House, Broad Street (County Road 59), Pine Apple, Wilcox County, AL
15. Historic American Buildings Survey Alex Bush, Photographer, March 24, ...
15. Historic American Buildings Survey Alex Bush, Photographer, March 24, 1937 LOOKING NORTH IN CROSS HALL, SECOND FLOOR - Colonel Joseph R. Hawthorne House, Broad Street (County Road 59), Pine Apple, Wilcox County, AL
14. Historic American Buildings Survey Alex Bush, Photographer, March 24, ...
14. Historic American Buildings Survey Alex Bush, Photographer, March 24, 1937 MANTEL ON NORTH WALL OF DINING ROOM - Colonel Joseph R. Hawthorne House, Broad Street (County Road 59), Pine Apple, Wilcox County, AL
Federal Register 2010, 2011, 2012, 2013, 2014
2011-07-05
...: Betsy Metcalf, Enforcement Targeting & Data Division, Office of Compliance, 2222A, Environmental... agencies. Dated: June 28, 2011. Joseph A. Sierra, Acting Director, Collection Strategies Division. [FR Doc...
76 FR 35070 - Canexus Chemicals Canada L.P. v. BNSF Railway Company
Federal Register 2010, 2011, 2012, 2013, 2014
2011-06-15
... FURTHER INFORMATION, CONTACT: Joseph Dettmar, (202) 245-0395. Assistance for the hearing impaired is... conservation of energy resources. Decided: June 10, 2011. By the Board. Rachel D. Campbell, Director, Office of...
Federal Register 2010, 2011, 2012, 2013, 2014
2010-02-03
... County Line Road, Altus Segment (Arkansas Highway History and Architecture MPS), Connector Rd. between...., Gloucester, 10000040 Middlesex County Saint Joseph's Roman Catholic College for Boys, 760 Merrimack St...
15. Photocopy from Futhey and Cope's History of Chester County, ...
15. Photocopy from Futhey and Cope's History of Chester County, Pennsylvania, 1881, facing page 27 VIEW OF FARM - Joseph Jackson House, Old Baltimore Pike (London Grove Township), West Grove, Chester County, PA
Congenital abnormalities in Liberian neonates.
Njoh, J; Chellaram, R; Ramas, L
1991-01-01
A seven-and-half-month study of single observations for congenital malformations on 2228 Liberian neonates at the St. Joseph's Catholic Hospital is presented. An overall incidence of 22.4 per 1000 was recorded in this study.
2. Historic American Buildings Survey Charles E. Peterson, Photographer July ...
2. Historic American Buildings Survey Charles E. Peterson, Photographer July 29, 1940. VIEW FROM SOUTH - Joseph R. Brown House, Sam Brown Memorial Park (moved from Dakota Territory), Browns Valley, Traverse County, MN
3. Historic American Buildings Survey Charles E. Peterson, Photographer July ...
3. Historic American Buildings Survey Charles E. Peterson, Photographer July 29, 1940. VIEW FROM THE WEST - Joseph R. Brown House, Sam Brown Memorial Park (moved from Dakota Territory), Browns Valley, Traverse County, MN
4. Historic American Buildings Survey Charles E. Peterson, Photographer July ...
4. Historic American Buildings Survey Charles E. Peterson, Photographer July 29, 1940 VIEW FROM NORTHEAST - Joseph R. Brown House, Sam Brown Memorial Park (moved from Dakota Territory), Browns Valley, Traverse County, MN
Rival Centennial Casts New Light on Edison.
ERIC Educational Resources Information Center
Broad, William J.
1979-01-01
Discusses how the celebration of the centennial of the electric lamp raises the claim of the supporters of Sir Joseph Swan in England that Swan not Edison was the first inventor of the light bulb. (HM)
31. Panoramic shot, Huber Breaker (left), Retail Coal Storage Bins ...
31. Panoramic shot, Huber Breaker (left), Retail Coal Storage Bins (center), Boney Elevator (right) Photographs taken by Joseph E.B. Elliot - Huber Coal Breaker, 101 South Main Street, Ashley, Luzerne County, PA
NASA Astrophysics Data System (ADS)
Gruber, Ralf; Keller, Vincent
In 2006, Joseph A. Stanislaw (American economist) wrote "Energy: The 21 st Century Challenge". Based on the same observation (one of the main concerns of the inhabitants of the Earth), this first chapter introduces the context of the book.
8. INTERIOR BEADED WALL BOARDING SHOWING TRIAL MARKS FROM DIES ...
8. INTERIOR BEADED WALL BOARDING SHOWING TRIAL MARKS FROM DIES MADE IN CARPENTER'S SHOP Ph: Jack E, Boucher - March 1961 - Joseph Carpenter Silversmith Shop, 71 East Town Street, Norwichtown, New London County, CT
Commemorative Displays: Bridging the Gap Between Past and Present.
ERIC Educational Resources Information Center
Stock, John T.
1984-01-01
Suggests preparing displays which include both dynamic and static items to attract observers' attention and hold their interest. Includes instructions for making exhibits related to phenomena associated with Joseph Priestley and Michael Faraday. (DH)
DOE Office of Scientific and Technical Information (OSTI.GOV)
Conlon, Brian P.; Nakayasu, Ernesto S.; Fleck, Laura E.
The current antibiotic crisis stems from two distinct phenomena-drug resistance, and drug tolerance. Resistance mechanisms such as drug efflux or modification prevent antibiotics from binding to their targets 1, allowing pathogens to grow. Antibiotic tolerance is the property of persister cells, phenotypic variants of regular bacteria 2. Antibiotics kill by corrupting targets, but these are inactive in dormant persisters, leading to tolerance. Persisters were first identified by Joseph Bigger in 1944, when he discovered a surviving sub-population of Staphylococcus following treatment with penicillin3. Persisters are largely responsible for recalcitrance of chronic diseases such as tuberculosis, and various infections associated withmore » biofilms - endocarditis, osteomyelitis, infections of catheters and indwelling devices, and deep-seated infections of soft tissues 4. There are a number of redundant pathways involved in persister formation5,6 precluding development of drugs inhibiting their formation. The acyldepsipeptide antibiotic (ADEP 4) has been shown to activate the ClpP protease resulting in death of growing cells 7. Here we show that ADEP4 activated ClpP becomes a fairly non-specific protease and kills persister cells by degradation of over 400 intracellular targets. clpP mutants are resistant to ADEP4 7, but we find that they display increased susceptibility to killing by a range of conventional antibiotics. Combining ADEP4 with rifampicin leads to eradication of persisters, stationary and biofilm populations of Staphylococcus aureus in vitro and in a deep-seated murine infection. Target corruption/activation provides an approach to killing persisters and eradicating chronic infections.« less
Arsenic speciation in arsenic-rich Brazilian soils from gold mining sites under anaerobic incubation
De Mello, J. W. V.; Talbott, J.L.; Scott, J.; Roy, W.R.; Stucki, J.W.
2007-01-01
Background. Arsenic speciation in environmental samples is essential for studying toxicity, mobility and bio-transformation of As in aquatic and terrestrial environments. Although the inorganic species As(III) and As(V) have been considered dominant in soils and sediments, organisms are able to metabolize inorganic forms of arsenic into organo-arsenic compounds. Arsenosugars and methylated As compounds can be found in terrestrial organisms, but they generally occur only as minor constituents. We investigated the dynamics of arsenic species under anaerobic conditions in soils surrounding gold mining areas from Minas Gerais State, Brazil to elucidate the arsenic biogeochemical cycle and water contamination mechanisms. Methods. Surface soil samples were collected at those sites, namely Paracatu Formation, Banded Iron Formation and Riacho dos Machados Sequence, and incubated in CaCl2 2.5 mmol L-1 suspensions under anaerobic conditions for 1, 28, 56 and 112 days. After that, suspensions were centrifuged and supernatants analyzed for soluble As species by IC-ICPMS and HPLC-ICPMS. Results. Easily exchangeable As was mainly arsenite, except when reducible manganese was present. Arsenate was mainly responsible for the increase in soluble arsenic due to the reductive dissolution of either iron or manganese in samples from the Paracatu Formation and Riacho dos Machados Sequence. On the other hand, organic species of As dominated in samples from the Banded Iron Formation during anaerobic incubation. Discussion. Results are contrary to the expectation that, in anaerobic environments, As release due to the reductive dissolution of Fe is followed by As(V) reduction to As(III). The occurrence of organo-arsenic species was also found to be significant to the dynamics of soluble arsenic, mainly in soils from the Banded Iron Formation (BIF), under our experimental conditions. Conclusions. In general, As(V) and organic As were the dominant species in solution, which is surprising under anaerobic conditions in terrestrial environments. The unexpected occurrence of organic species of As was attributed to enrollment of ternary organic complexes or living organisms such as algae or cyanobacteria. Perspectives. These findings are believed to be useful for remediation strategies in mine-affected regions, as the organic As species are in general considered to be less toxic than inorganic ones and even As(V) is considered less mobile and toxic than As(III). ?? 2007 ecomed publishers (Verlagsgruppe Hu??thig Jehle Rehm GmbH).
DOT National Transportation Integrated Search
2000-04-01
This presentation was given by Prof. Joseph M. Sussman of MIT during the closing plenary session of the Institute of Transportation Engineers 2000 Conference entitled "Transportation Operations - Moving into the 21st Century" on April 5, 2000 in Irvi...
22. Greenhouse, south elevation. This winter 2002 view was taken ...
22. Greenhouse, south elevation. This winter 2002 view was taken by Joseph Elliot while conducting photographic documentation of the landscape. - John Bartram House & Garden, Greenhouse, 54th Street & LIndbergh Boulevard, Philadelphia, Philadelphia County, PA
3. Historic American Buildings Survey Alex Bush, Photographer, March 24, ...
3. Historic American Buildings Survey Alex Bush, Photographer, March 24, 1937 CLOSE-UP OF FRONT ELEVATION FROM SOUTH SIDE - Colonel Joseph R. Hawthorne House, Broad Street (County Road 59), Pine Apple, Wilcox County, AL
10. Historic American Buildings Survey Alex Bush, Photographer, March 24, ...
10. Historic American Buildings Survey Alex Bush, Photographer, March 24, 1937 VIEW IN FRONT OF MAIN HALL, SECOND FLOOR - Colonel Joseph R. Hawthorne House, Broad Street (County Road 59), Pine Apple, Wilcox County, AL
9. Historic American Buildings Survey Alex Bush, Photographer, March 24, ...
9. Historic American Buildings Survey Alex Bush, Photographer, March 24, 1937 VIEW THROUGH DOUBLE SLIDING DOORS INTO DINING ROOM - Colonel Joseph R. Hawthorne House, Broad Street (County Road 59), Pine Apple, Wilcox County, AL
7. Historic American Buildings Survey Verlin Berry, Photographer November 10, ...
7. Historic American Buildings Survey Verlin Berry, Photographer November 10, 1977 FIRST FLOOR, VIEW OF PRESSED TIN CEILING WITH WOOD BLOCKING AT CROWN MOLDING - 111 West First Street (Commercial Building), Mishawaka, St. Joseph County, IN
11. Historic American Buildings Survey Verlin Berry, Photographer October 21, ...
11. Historic American Buildings Survey Verlin Berry, Photographer October 21, 1977 121 NORTH MAIN STREET, FIRST FLOOR, VIEW OF PRESSED TIN CEILING - 121-125 North Main Street (Commercial Building), Mishawaka, St. Joseph County, IN
ERIC Educational Resources Information Center
School Library Journal, 1976
1976-01-01
The suit claimed violation of First and Fourteenth Amendment rights in that the school board, disregarding the recommendation of faculty, refused to approve Joseph Heller's "Catch 22" and Kurt Vonnegut's "God Bless You, Mr. Rosewater" as texts or library books. (Author)
76 FR 71584 - Notice of Revocation of Customs Broker Licenses
Federal Register 2010, 2011, 2012, 2013, 2014
2011-11-18
... Antonelli Joseph 04804 New York Rosenberg Edward 02869 New York Kim Haingduck 16243 New York Solomon Julius... 17090 New York Digena Stephanie 16624 New York Four Corners, Inc 16691 New York Juliussen Ellen 15497...
Federal Register 2010, 2011, 2012, 2013, 2014
2010-11-05
..., Inc. at the specified station in Chester County. FOR FURTHER INFORMATION CONTACT: Joseph H. Dettmar..., Rachel D. Campbell, Director, Office of Proceedings. Andrea Pope-Matheson, Clearance Clerk. [FR Doc. 2010...
Chapter 8 : into the 21st century.
DOT National Transportation Integrated Search
2008-01-01
On January 20, 1993, William Jefferson Clinton became the : forty-second President of the United States, succeeding George : H.W. Bush. FAA Administrator Thomas Richards left office with : the Bush Administration, and Joseph Del Balzo became acting :...
House Subcommittee - Manned Spaceflight - MSC
1964-02-15
George Low, Joseph Piland, Philip Hamburger, Congressman Olin Teague from Texas; and, Congressman Joe D. Waggoner from Louisiana at the entrance to Site 1, Clear Lake, prior to briefing for the House Subcommittee on Manned Spaceflight. MSC, Houston, TX
1. Historic American Buildings Survey Charles E. Peterson, Photographer Copied ...
1. Historic American Buildings Survey Charles E. Peterson, Photographer Copied July 29, 1940 Copied from old photograph - Joseph R. Brown House, Sam Brown Memorial Park (moved from Dakota Territory), Browns Valley, Traverse County, MN
Federal Register 2010, 2011, 2012, 2013, 2014
2013-01-24
..., Joseph Bosshard and Makenzie Bosshard, both of Boulder, Colorado, Nathan Bosshard-Blakely, Berkeley, California, Elizabeth Bosshard-Blakely, South Pasadena, California, Alexandra Bosshard, Sandy, Utah, and John...
NASA Technical Reports Server (NTRS)
Garcia, Joseph A.; Smith, Charles A. (Technical Monitor)
1998-01-01
The document consists of a publicly available web site (george.arc.nasa.gov) for Joseph A. Garcia's personal web pages in the AI division. Only general information will be posted and no technical material. All the information is unclassified.
40 CFR 52.146 - Particulate matter (PM-10) Group II SIP commitments.
Code of Federal Regulations, 2010 CFR
2010-07-01
... submitted a revision to the State Implementation Plan (SIP) for Casa Grande, Show Low, Safford, Flagstaff... Implementation Plan (SIP) requirements for Casa Grande, Show Low, Safford, Flagstaff and Joseph City as provided...
77 FR 43900 - Senior Executive Service Performance Review Boards Membership
Federal Register 2010, 2011, 2012, 2013, 2014
2012-07-26
..., Jeffrey F. Peters, Joseph I. Ridenour, Melisa Lee Saunders, Ian C. Shepard, Gloria Morgan Solomon, Gerald..., Magdy A. Mayberry, Alan K. Posten, R. Ryan Poyer, Scott A. Summitt, Monica J. Wiese, Jeffrey D. Research...
9. Photocopy of old photo shows a general view of ...
9. Photocopy of old photo shows a general view of the church, date unknown, Original photograph at Idaho Historical Society, Boise, Idaho - St. Joseph's Roman Catholic Church, High & Wallula Streets, Idaho City, Boise County, ID
Whatever Happened to Formal Methods for Security?
Voas, J; Schaffer, K
2016-08-01
We asked 7 experts 7 questions to find out what has occurred recently in terms of applying formal methods (FM) to security-centric, cyber problems. We are continually reminded of the 1996 paper by Tony Hoare "How did Software Get So Reliable Without Proof?" [1] In that vein, how did we get so insecure with proof? Given daily press announcements concerning new malware, data breaches, and privacy loss, is FM still relevant or was it ever? Our experts answered with unique personal insights. We were curious as to whether this successful methodology in "safety-critical" has succeeded as well for today's "build it, hack it, patch it" mindset. Our experts were John McLean (Naval Research Labs), Paul Black (National Institute of Standards and Technology), Karl Levitt (University of California at Davis), Joseph Williams (CloudEconomist.Com), Connie Heitmeyer (Naval Research Labs), Eugene Spafford (Purdue University), and Joseph Kiniry (Galois, Inc.). The questions and responses follow.
Joseph Lovell, MD (1788-1836): First US army surgeon general.
Craig, Stephen C
2016-08-01
Joseph Lovell, trained in medicine at Harvard and in military medicine/surgery by the War of 1812, became the first Surgeon General to sit on the reorganised army staff at the tender age of 29 in 1818. With a keen intellect, medical acumen, and wartime experiences for his tools and a close supporting relationship with Commanding General Jacob Jennings Brown and Secretary of War John C Calhoun (1728-1850), Lovell constructed an efficient and effective organisational and administrative framework for the new Medical Department of the US Army. Moreover, he not only redefined the role of the American military physician but also established the professional dignity, respectability and value of the medical officer among line officers and staff. Lovell's 18-year tenure came to an abrupt end, but the operational framework he created became both foundation and legacy for his successors. © Author(s) 2016.
[Dr. Joseph Chazanowicz (1844-1919) and the National Library in Jerusalem].
Ohry, Avi
2014-01-01
Dr. Joseph Chazanowicz (1844-1919), was a Russian physician, and founder of the Jewish National Library in JerusaLem. After completing his studies at the Jewish school and at the gymnasium of Grodno, Chazanowicz went to Königsberg, Germany to study medicine and finished his studies in 1872. Returning to Russia, he began to practice at Byelostok's Jewish hospital. Chazanowicz founded the Hovevei Ziyyon ["Lovers of Zion"] society and also the Linat Ha-Zedek ("Hospice for the Poor")--caring for the poor. In 1890 he visited Palestine and conceived the idea of founding a library in Jerusalem, together with the B'nai B'rith organization. In 1896 he sent his large collection of books, amounting to nearly 10,000 volumes, to Jerusalem as the beginning of the Abarbanel library. The enlargement of this library and the collection of funds to erect a special building for it became the life-work of Chazanowicz.
Price, Don; Stephens, D.W.; Conroy, L.S.
1989-01-01
The hydrologic resources in and adjacent to five parcels of land held in trust for the Paiute Indian Tribe of Utah were evaluated. The land, located in southwestern Utah, is generally arid and has had only limited use for grazing. The parcels are located near the towns of Cove Fort, Joseph, Koosharem, and Kanarraville. On the basis of available geohydrologic and hydrologic data, water of suitable quality is locally available in the areas of all parcels for domestic, stock, recreation, and limited irrigation use. Developing this water for use on the parcels would potentially involve obtaining water rights, drilling wells, and constructing diversion structures. Surface water apparently is the most favorable source of supply available for the Joseph parcel, and groundwater apparently is the most favorable source of supply available for the other parcels. (USGS)
Johnston, Timothy D
2003-02-01
Scientific comparative psychology in America dates from the mid-1890s, but there is a body of earlier literature on the topic, written during a period of theistic debates over Darwinian evolution. The anthropologist Lewis H. Morgan rejected instinct as an explanation of animal behavior in 1843 and defended the mental similarities between animals and humans, although he was not an evolutionist. John Bascom's textbook Comparative Psychology (1878) is the earliest American work to use that title, and its theistic approach anticipates some arguments found in much later evolutionary works. Beginning in 1860, the geologist Joseph LeConte, who is well known for defending the compatibility of evolution and religion, wrote several articles in which he outlined a comparative evolutionary approach to psychological problems. However, these writers did not establish a coherent research tradition and were ignored by the "New Psychologists" of the 1880s.
Jacques-Joseph Ébelmen, the founder of earth system science
NASA Astrophysics Data System (ADS)
Berner, Robert A.
2012-11-01
The fundamental principles of the factors affecting the global carbon cycle, the global sulfur cycle and the levels of atmospheric CO2 and O2 over long-term (multimillion year) time scales were first elucidated by Jacques-Joseph Ébelmen in 1845. He covered all major processes in such a correct manner that no appreciable changes in them have been elucidated since then. Unfortunately, his ideas were forgotten and were independently deduced by others only 100 to 150 years later. In this article, his reasoning is shown in detail, via a number of original quotations, and the results of a mathematical model by the author for CO2 and O2 over the Phanerozoic Eon (past 542 million years) are presented. In agreement with Ébelmen's predictions, there apparently have been large changes in the levels of atmospheric CO2 and O2 over geologic time.
NASA Astrophysics Data System (ADS)
de Berg, Kevin C.
2011-07-01
This paper discusses the findings of a search for the intellectual tools used by Joseph Priestley (1733-1804) in his chemistry, education, and theology documents. Priestley's enquiring democratic view of knowledge was applicable in all three areas and constitutes a significant part of his lifework. Current epistemological issues in science education are examined from the point of view of the nature of theory and experiment as observed in Priestley's writings and as espoused in modern philosophy of science. Science and religious faith issues in the context of science education are examined from the point of view of one's understanding of sacred texts, and the suggestion is made that a Priestleyan model of "the liberty to think for oneself" and "to hold knowledge with humility and virtue" could prove helpful in dealing with the known divergent opinions in relation to science, education, and religion.
A Science Superior to Music: Joseph Sauveur and the Estrangement between Music and Acoustics
NASA Astrophysics Data System (ADS)
Fix, Adam
2015-09-01
The scientific revolution saw a shift from the natural philosophy of music to the science of acoustics. Joseph Sauveur (1653-1716), an early pioneer in acoustics, determined that science as understood in the eighteenth century could not address the fundamental problems of music, particularly the problem of consonance. Building on Descartes, Mersenne, and Huygens especially, Sauveur drew a sharp divide between sound and music, recognizing the former as a physical phenomenon obeying mechanical and mathematical principles and the latter as an inescapably subjective and unquantifiable perception. While acoustics grew prominent in the Académie des sciences, music largely fell out of the scientific discourse, becoming primarily practiced art rather than natural philosophy. This study illuminates what was considered proper science at the dawn of the Enlightenment and why one particular branch of natural philosophy—music—did not make the cut.
ASTRONAUT KERWIN, JOSEPH P. - ART CONCEPTS
1975-02-05
S75-21432 (March 1975) --- An artist's concept illustrating a scene during the June 7, 1973 Skylab 2 extravehicular activity in Earth orbit when astronauts Joseph P. Kerwin (larger figure) and Charles Conrad Jr. cut the aluminum strapping which prevented the Skylab Orbital Workshop solar array system wing from deploying. The solar panel was successfully deployed. The painting is by artist Paul Fjeld. The action portrayed here is about two to four seconds after using the beam erection tether, the two crewmen broke the frozen SAS beam actuators. This artistic effort took weeks to research and a day and a half to paint. Fjeld said that he needed some hundred or so photographs to get all the details for the painting. He struggled through about 300 pages of transcripts from the flight. Also, he used several pages of teleprinter messages which were the actual instructions on the EVA that the two astronauts used in flight. Photo credit: NASA
Anderson, Jahue
2011-01-01
This is the story of failure: in this case, an irrigation project that never met its boosters' expectations. Between 1880 and 1930, Wichita Falls entrepreneur Joseph Kemp dreamed of an agrarian Eden on the Texas rolling plains. Kemp promoted reclamation and conservation and envisioned the Big Wichita River Valley as the "Irrigated Valley." But the process of bringing dams and irrigation ditches to the Big Wichita River ignored knowledge of the river and local environment, which ultimately was key to making these complex systems work. The boosters faced serious ecological limitations and political obstacles in their efforts to conquer water, accomplishing only parts of the grandiose vision. Ultimately, salty waters and poor drainage doomed the project. While the livestock industry survived and the oil business thrived in the subsequent decades, the dream of idyllic irrigated farmsteads slowly disappeared.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Hauer, John F.; Mittelstadt, William; Martin, Kenneth E.
During 2005 and 2006 the Western Electricity Coordinating Council (WECC) performed three major tests of western system dynamics. These tests used a Wide Area Measurement System (WAMS) based primarily on Phasor Measurement Units (PMUs) to determine response to events including the insertion of the 1400-MW Chief Joseph braking resistor, probing signals, and ambient events. Test security was reinforced through real-time analysis of wide area effects, and high-quality data provided dynamic profiles for interarea modes across the entire western interconnection. The tests established that low-level optimized pseudo-random ±20-MW probing with the Pacific DC Intertie (PDCI) roughly doubles the apparent noise thatmore » is natural to the power system, providing sharp dynamic information with negligible interference to system operations. Such probing is an effective alternative to use of the 1400-MW Chief Joseph dynamic brake, and it is under consideration as a standard means for assessing dynamic security.« less
Economic dynamics with financial fragility and mean-field interaction: A model
NASA Astrophysics Data System (ADS)
Di Guilmi, C.; Gallegati, M.; Landini, S.
2008-06-01
Following Aoki’s statistical mechanics methodology [Masanao Aoki, New Approaches to Macroeconomic Modeling, Cambridge University Press, 1996; Masanao Aoki, Modeling Aggregate Behaviour and Fluctuations in Economics, Cambridge University Press, 2002; Masanao Aoki, and Hiroshi Yoshikawa, Reconstructing Macroeconomics, Cambridge University Press, 2006], we provide some insights into the well-known works of [Bruce Greenwald, Joseph Stiglitz, Macroeconomic models with equity and credit rationing, in: R. Hubbard (Ed.), Information, Capital Markets and Investment, Chicago University Press, Chicago, 1990; Bruce Greenwald, Joseph Stiglitz, Financial markets imperfections and business cycles, Quarterly journal of Economics (1993)]. Specifically, we reach analytically a closed form solution of their models overcoming the aggregation problem. The key idea is to represent the economy as an evolving complex system, composed by heterogeneous interacting agents, that can be partitioned into a space of macroscopic states. This meso level of aggregation permits to adopt mean-field interaction modeling and master equation techniques.
The Scientific Papers of the Honourable Henry Cavendish, F. R. S. 2 Volume Set
NASA Astrophysics Data System (ADS)
Cavendish, Henry; Clerk Maxwell, James; Thorpe, Edward, , Sir; Larmor, Joseph, , Sir
2011-02-01
Volume 1: Preface Sir Joseph Larmor; Introduction; First published paper on electricity, 1771; Preliminary propositions; Appendix; Thoughts concerning electricity; Account of the experiments; Second published paper on electricity, 1776; Experiments in 1771; Experiments in 1772; Experiments in 1773; Measurers; Experiments with the artificial torpedo; Resistance to electricity; Results of comparisons of charges; Results on resistance; Notes by the editor, 1879 James Clerk Maxwell; Life of Cavendish Thomas Young; Index to Cavendish Manuscripts. Volume 2: Introduction; Reprint of papers communicated by Cavendish to the Royal Society and published in the Philosophical Transactions; Unpublished papers from the original manuscripts in the possession of the Duke of Devonshire, K. G., LL. D., F. R. S.; Cavendish's mathematical and dynamical manuscripts Sir Joseph Larmor; Cavendish as a geologist Sir Archibald Geikie; Cavendish's astronomical manuscripts Sir Frank W. Dyson; Cavendish's magnetic work Charles Chree; Index.
Joseph Henry’s role in the discovery of electromagnetic induction
NASA Astrophysics Data System (ADS)
Smith, Glenn S.
2017-01-01
The discovery of electromagnetic induction in the early part of the 19th century is one of the greatest scientific achievements of all time, and it has had tremendous technological consequences. The credit for this discovery rightfully goes to the great English experimental physicist Michael Faraday. However, the American physicist Joseph Henry made some observations comparable to Faraday’s at nearly the same time, and for that reason, Faraday and Henry are often considered to be co-discoverers of some aspects of electromagnetic induction. We examine Henry’s early research on electromagnetism, starting from his efforts to improve the electromagnet, which led directly to his investigations of induction. We describe his earliest experiments on both mutual and self-induction, and pay particular attention to the relationship of Henry’s research to that of Faraday. The approach is one in which the experiments are described and then analysed using modern theory and terminology.
Sir Joseph Barcroft: one victorian physiologist's contributions to a half century of discovery.
Longo, Lawrence D
2016-03-01
During the first half of the 20th Century, Joseph Barcroft, KBE, FRS of Cambridge University became a world leader in respiratory physiology. He determined the role of neural stimulation in the oxygen consumption of several organs, established many of the factors that regulate the binding of oxygen to haemoglobin, explored the determinants of a human's acclimatization to high altitude and developed the field of fetal cardiovascular physiology. Chair of the Cambridge Department of Physiology from 1925 to 1937, he served as a consultant and member of many UK governmental committees. During World War I, he led a British research unit exploring the effects of poisonous gases on pulmonary function and related problems. In addition to his almost 300 publications, several of his monographs are considered as classics. © 2015 The Authors. The Journal of Physiology © 2015 The Physiological Society.
Kong, Hyejung Grace; Kim, Ock-Joo
2015-04-01
This study is about the Sisters of Charity of St. Joseph in New Orleans' Charity Hospital during the years between 1834 and 1860. The Sisters of Charity of St. Joseph was founded in 1809 by Saint Elizabeth Ann Bailey Seton (first native-born North American canonized in 1975) in Emmitsburg, Maryland. Seton's Sisters of Charity was the first community for religious women to be established in the United States and was later incorporated with the French Daughters of Charity of St. Vincent de Paul in 1850. A call to work in New Orleans' Charity Hospital in the 1830s meant a significant achievement for the Sisters of Charity, since it was the second oldest continuously operating public hospitals in the United States until 2005, bearing the same name over the decades. In 1834, Sister Regina Smith and other sisters were officially called to Charity Hospital, in order to supersede the existing "nurses, attendants, and servants," and take a complete charge of the internal management of Charity Hospital. The existing scholarship on the history of hospitals and Catholic nursing has not integrated the concrete stories of the Sisters of Charity into the broader histories of institutionalized medicine, gender, and religion. Along with a variety of primary sources, this study primarily relies on the Charity Hospital History Folder stored at the Daughters of Charity West Center Province Archives. Located in the "Queen city of the South," Charity Hospital was the center of the southern medical profession and the world's fair of people and diseases. Charity Hospital provided the sisters with a unique situation that religion and medicine became intertwined. The Sisters, as nurses, constructed a new atmosphere of caring for patients and even their families inside and outside the hospital, and built their own separate space within the hospital walls. As hospital managers, the Sisters of Charity were put in complete charge of the hospital, which was never seen in other hospitals. By wearing a distinctive religious garment, they eschewed female dependence and sexuality. As medical and religious attendants at the sick wards, the sisters played a vital role in preparing the patients for a "good death" as well as spiritual wellness. By waging their own war on the Protestant influences, the sisters did their best to build their own sacred place in caring for sick bodies and saving souls. Through the research on the Sisters of Charity at Charity Hospital, this study ultimately sheds light on the ways in which a nineteenth-century southern hospital functioned as a unique environment for the recovery of wellness of the body and soul, shaped and envisioned by the Catholic sister-nurses' gender and religious identities.
Reforming the American Military Officer Personnel System
2015-12-02
Lamping Lewis, Henry Leonard, Julia Pollak, Christopher Guo and Bernard Rostker, Tour Lengths, Permanent Changes of Station, and Alternatives for...Raymond E. Conley, Stephanie Young, William A. Williams, Jeffrey Engstrom, Barbara Bicksler, Sara Beth Elson, Joseph Jenkins , Lianne Kennedy
ERIC Educational Resources Information Center
Kealey, Robert J., Comp.
The essays in this collection reflect on effective practices conducted in Catholic schools. Essays were written by participants in the 2000 principals' academy. Under "Section 1: Religious Education" are the following essays: "Kingdom Builders" (Sr. M. Joseph); "Sacramental Programs, Parish Programs" (J. Thaler); and…
1. COMPARATIVE VIEW OF THREE RESIDENTIAL STRUCTURES, 203 1/2 TO ...
1. COMPARATIVE VIEW OF THREE RESIDENTIAL STRUCTURES, 203 1/2 TO 205 WHITTIER, BUILT IN 1905, NORTH FRONTS LOOKING SOUTH - Joseph & Emma May Hoover House, 203 1/2 West Whittier Avenue, Altoona, Blair County, PA
46 CFR 45.197 - Operational plan requirements for the Muskegon route.
Code of Federal Regulations, 2010 CFR
2010-10-01
.... (b) A list of mooring and docking facilities (with phone numbers) in St. Joseph, Holland, Grand Haven, and Muskegon, that can accommodate the tow. (c) A list of towing firms (with phone numbers) that have...
9. Historic American Buildings Survey Arthur C. Haskell, Photographer Nov. ...
9. Historic American Buildings Survey Arthur C. Haskell, Photographer Nov. 2, 1937 (i) INT.- SOUTHEAST WALL, WEST ROOM, 1st. FLOOR - General Joseph Dwight House, U.S. Route 7 & State Route 23, Great Barrington, Berkshire County, MA
NASA Technical Reports Server (NTRS)
1973-01-01
Skylab 2 Commander Charles Conrad is seen undergoing a dental examination by the Medical Officer, Joseph Kerwin in the Skylab Medical Facility. In the absence of an examination chair, Conrad simply rotated his body to an upside down position to facilitate the procedure.
ERIC Educational Resources Information Center
Flannery, Maura C.
2002-01-01
Describes the diversity of flowers with regard to the flower paintings of Pierre-Joseph Redoute, books about flowers, and research in genetic studies. Discusses gardening flowers and flowering strategies and criticizes the fact that biology education has moved steadily away from plants. (KHR)
Ground-water quality in northeastern St. Joseph County, Indiana
Fenelon, J.M.; Bayless, E. Randall; Watson, Lee R.
1995-01-01
No industrial organic compounds were detected in the water samples. Four pesticides - alachlor, carbofuran, metolachlor, and triazines - were detected in water samples; the highest pesticide concentration in a water sample was 1.0 microgram per liter of alachlor.
Early Geologic Education in California--Berkeley and Stanford Show the Way.
ERIC Educational Resources Information Center
Norris, Robert M.
1981-01-01
Traces the early history of geological education in California universities, with emphasis upon programs at Berkeley and Stanford. Among the pioneers in the field were Joseph LeConte, Andrew C. Lawson, and John C. Branner. (WB)
Understanding Innovation Adoption in the Air Force
2006-03-01
Innovation Management , 19: 110-132 (2002). Gleim, Joseph A. and Rosemary Gleim. “Calculating, Interpreting, and Reporting Chronbach’s Alpha...Calantone. “A Critical Look at Technological Innovation Typology and Innovativeness Terminology: A Literature Review,” The Journal of Product
33. Coal Fuel Elevator (diagonal in foreground), Fuel Elevator (left), ...
33. Coal Fuel Elevator (diagonal in foreground), Fuel Elevator (left), Fuel Storage Bins (center), and Power Plant (right) Photographs taken by Joseph E.B. Elliot - Huber Coal Breaker, 101 South Main Street, Ashley, Luzerne County, PA
[Josephinism in medicine: the General Hospital in Vienna and the "Narrenturm" (insane asylum)].
Sablik, K
1991-01-01
The spirit of enlightened absolutism was realized through the personal engagement of Emperor Joseph II in the foundation of the Vienna General Hospital, the asylum for the insane called "Narrenturm" and the maternity home.
53. Retail Pockets, Looking West, date unknown Historic Photograph, Photogapher ...
53. Retail Pockets, Looking West, date unknown Historic Photograph, Photogapher Unknown; Collection of William Everett, Jr. (Wilkes-Barre, PA), photocopy by Joseph E.B. Elliot - Huber Coal Breaker, 101 South Main Street, Ashley, Luzerne County, PA
10. Photocopy of old photo shows another general view of ...
10. Photocopy of old photo shows another general view of the church, taken June 1961. Original photograph at Idaho Historical Society, Boise, Idaho - St. Joseph's Roman Catholic Church, High & Wallula Streets, Idaho City, Boise County, ID
46 CFR 45.197 - Operational plan requirements for the Muskegon route.
Code of Federal Regulations, 2011 CFR
2011-10-01
.... (b) A list of mooring and docking facilities (with phone numbers) in St. Joseph, Holland, Grand Haven, and Muskegon, that can accommodate the tow. (c) A list of towing firms (with phone numbers) that have...
46 CFR 45.197 - Operational plan requirements for the Muskegon route.
Code of Federal Regulations, 2012 CFR
2012-10-01
.... (b) A list of mooring and docking facilities (with phone numbers) in St. Joseph, Holland, Grand Haven, and Muskegon, that can accommodate the tow. (c) A list of towing firms (with phone numbers) that have...
46 CFR 45.197 - Operational plan requirements for the Muskegon route.
Code of Federal Regulations, 2014 CFR
2014-10-01
.... (b) A list of mooring and docking facilities (with phone numbers) in St. Joseph, Holland, Grand Haven, and Muskegon, that can accommodate the tow. (c) A list of towing firms (with phone numbers) that have...
46 CFR 45.197 - Operational plan requirements for the Muskegon route.
Code of Federal Regulations, 2013 CFR
2013-10-01
.... (b) A list of mooring and docking facilities (with phone numbers) in St. Joseph, Holland, Grand Haven, and Muskegon, that can accommodate the tow. (c) A list of towing firms (with phone numbers) that have...
1966-10-01
Lunar Orbiter 1 photographed Earth from the moon, this image was called "the image of the century" published in " A Century at Langley" by Joseph Chambers Pg.93. Also in the book " A Bunch of Plambers" by John Newcomb pg. 92.
Federal Register 2010, 2011, 2012, 2013, 2014
2013-10-22
..., SEC, dated July 29, 2013 (``FSI''); Howard Spindel, Senior Managing Director, and Cassondra E. Joseph..., Securities Arbitration Clinic of St. John's University School of Law, to Elizabeth M. Murphy, Secretary, SEC...
Spring 2007. Industry Study. Environment Industry
2007-01-01
Department of Air Force Mr. Ingo Kloss, European Aeronautic Defence, and Space Company, Inc. CAPT Eric Moss, US Navy Mr. Joseph Smith, Department of...Peter Layton , RAAF, Faculty, Department of National Security Studies ii PLACES VISITED Domestic: - Local - British Petroleum Solar
Flood-inundation maps for the St. Joseph River at Elkhart, Indiana
Martin, Zachary W.
2017-02-01
Digital flood-inundation maps for a 6.6-mile reach of the St. Joseph River at Elkhart, Indiana, were created by the U.S. Geological Survey (USGS) in cooperation with the Indiana Office of Community and Rural Affairs. The flood-inundation maps, which can be accessed through the USGS Flood Inundation Mapping Science Web site at https://water.usgs.gov/osw/flood_inundation/, depict estimates of the areal extent and depth of flooding corresponding to selected water levels (stages) at the USGS streamgage 04101000, St. Joseph River at Elkhart, Ind. Real-time stages at this streamgage may be obtained on the Internet from the USGS National Water Information System at https://waterdata.usgs.gov/nwis or the National Weather Service (NWS) Advanced Hydrologic Prediction Service at http:/water.weather.gov/ahps/, which also forecasts flood hydrographs at this site (NWS site EKMI3).Flood profiles were computed for the stream reach by means of a one-dimensional, step-backwater hydraulic modeling software developed by the U.S. Army Corps of Engineers. The hydraulic model was calibrated using the current stage-discharge rating at the USGS streamgage 04101000, St. Joseph River at Elkhart, Ind., and the documented high-water marks from the flood of March 1982. The hydraulic model was then used to compute six water-surface profiles for flood stages at 1-foot (ft) intervals referenced to the streamgage datum ranging from 23.0 ft (the NWS “action stage”) to 28.0 ft, which is the highest stage interval of the current USGS stage-discharge rating curve and 1 ft higher than the NWS “major flood stage.” The simulated water-surface profiles were then combined with a Geographic Information System digital elevation model (derived from light detection and ranging [lidar] data having a 0.49-ft root mean squared error and 4.9-ft horizontal resolution, resampled to a 10-ft grid) to delineate the area flooded at each stage.The availability of these maps, along with Internet information regarding current stage from the USGS streamgage and forecasted high-flow stages from the NWS, will provide emergency management personnel and residents with information that is critical for flood response activities such as evacuations and road closures, as well as for post-flood recovery efforts.
Mason, Clifford W; Swaan, Peter W; Weiner, Carl P
2006-06-01
The transition from myometrial quiescence to activation is poorly understood, and the analysis of array data is limited by the available data mining tools. We applied functional analysis and logical operations along regulatory gene networks to identify molecular processes and pathways underlying quiescence and activation. We analyzed some 18,400 transcripts and variants in guinea pig myometrium at stages corresponding to quiescence and activation, and compared them to the nonpregnant (control) counterpart using a functional mapping tool, MetaCore (GeneGo, St Joseph, MI) to identify novel gene networks composed of biological pathways during mid (MP) and late (LP) pregnancy. Genes altered during quiescence and or activation were identified following gene specific comparisons with myometrium from nonpregnant animals, and then linked to curated pathways and formulated networks. The MP and LP networks were subtracted from each other to identify unique genomic events during those periods. For example, changes 2-fold or greater in genes mediating protein biosynthesis, programmed cell death, microtubule polymerization, and microtubule based movement were noted during the transition to LP. We describe a novel approach combining microarrays and genetic data to identify networks associated with normal myometrial events. The resulting insights help identify potential biomarkers and permit future targeted investigations of these pathways or networks to confirm or refute their importance.
Resident Fish Stock above Chief Joseph and Grand Coulee Dams; 2003-2004 Annual Report.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Connor, Jason M.; McLellan, Jason G.; Butler, Chris
2005-11-01
In 1980, the United States Congress enacted the Northwest Power Planning and Conservation Act (PL 96-501, 1980), which established the Northwest Power and Conservation Council (NPCC), formerly the Northwest Power Planning Council. The NPCC was directed by Congress to develop a regional Power Plan and also the Columbia River Basin Fish and Wildlife Program (FWP) to restore or replace losses of fish caused by construction and operation of hydroelectric dams in the Columbia River Basin. In developing the FWP, Congress specifically directed NPCC to solicit recommendations for measures to be included in the Program from the region's fish and wildlifemore » agencies and Indian tribes. All measures adopted by the Council were also required to be consistent with the management objectives of the agencies and tribes [Section 4.(h)(6)(A)], the legal rights of Indian tribes in the region [Section 4.(h)(6)(D)] and be based upon and supported by the best available scientific knowledge [Section 4.(h)(6)(B)]. The Resident Fish Stock Status above Chief Joseph and Grand Coulee Dams Project, also known as the Joint Stock Assessment Project (JSAP) specifically addresses NPPC Council measure 10.8B.26 of the 1994 program. The Joint Stock Assessment Project is a management tool using ecosystem principles to manage artificial and native fish assemblages in altered environments existing in the Columbia River System above Chief Joseph and Grand Coulee Dams (Blocked Area). A three-phase approach of this project will enhance the fisheries resources of the Blocked Area by identifying data gaps, filling data gaps with research, and implementing management recommendations based on research results. The Blocked Area fisheries information is housed in a central location, allowing managers to view the entire system while making decisions, rather than basing management decisions on isolated portions of the system. The JSAP is designed and guided jointly by fisheries managers in the Blocked Area. The initial year of the project (1997) identified the need for a central data storage and analysis facility, coordination with the StreamNet project, compilation of Blocked Area fisheries information, and a report on the ecological condition of the Spokane River System. These needs were addressed in 1998 by acquiring a central location with a data storage and analysis system, coordinating a pilot project with StreamNet, compiling fisheries distribution data throughout the Blocked Area, identifying data gaps based on compiled information, and researching the ecological condition of the Spokane River. In order to ensure that any additional information collected throughout the life of this project will be easily stored and manipulated by the central storage facility, it was necessary to develop standardized methodologies between the JSAP fisheries managers. Common collection and analytical methodologies were developed in 1999. The project began addressing identified data gaps throughout the Blocked Area in 1999. Data collection of established projects and a variety of newly developed sampling projects are ongoing. Projects developed and undertaken by JSAP fisheries managers include investigations of the Pend Orielle River and its tributaries, the Little Spokane River and its tributaries, and water bodies within and near the Spokane Indian Reservation. Migration patterns of adfluvial and reservoir fish in Box Canyon Reservoir and its tributaries, a baseline assessment of Boundary Reservoir and its tributaries, ecological assessment of mountain lakes in Pend Oreille County, and assessments of streams and lakes on the Spokane Indian Reservation were completed by 2001. Assessments of the Little Spokane River and its tributaries, Spokane River below Spokane Falls, tributaries to the Pend Oreille River, small lakes in Pend Oreille County, WA, and water bodies within and near the Spokane Indian Reservation were conducted in 2002 and 2003. This work was done in accordance with the scope of work approved by Bonneville Power Administration (BPA).« less
Mission control activity during STS-61 EVA-1
1993-12-05
Joseph Fanelli, at the Integrated Communications Officer console, monitors the televised activity of Astronauts Story Musgrave and Jeffrey A. Hoffman. The vetern astronauts were performing the first extravehicular activity (EVA-1) of the STS-61 Hubble Space Telescope (HST) servicing mission.
JPRS Report, East Asia, Southeast Asia.
1991-04-05
election. Senate Bill No. 1742 was proposed by Senators Ernesto Macdea, Ernesto Herrera, Mamintal Tasmano, Orlando Mercado , John Osmena, and Joseph... municipalities , and spe- cial zones were fighting against and effectively stopping smugglers, discovered and handled more than 20,000 cases of
Florida Journal of Communication Disorders, 1997.
ERIC Educational Resources Information Center
Langhans, Joseph J., Ed.
1997-01-01
This annual volume is a compilation of traditional articles, poster publications and clinical reports addressing speech and language impairments and intervention. Featured articles include: (1) "Pantomime Recognition and Pantomime Expression in Persons with Aphasia" (Joseph J. Langhans); (2) "Bilingual Classroom Discourse Skills: An…
Remediation System Evaluation, Douglas Road Landfill Superfund Site
The Douglas Road Landfill Superfund Site is located in St. Joseph County just north of Mishawaka,Indiana. The site consists of a 16-acre capped landfill located on an approximately 32-acre lot (includingthe land purchased in 1999 for a wetlands...
ERIC Educational Resources Information Center
Bookmark, 1991
1991-01-01
The 12 articles in this issue focus on the theme of family history resources: (1) "Introduction: Family History Resources" (Joseph F. Shubert); (2) "Work, Credentials, and Expectations of a Professional Genealogist" (Coreen P. Hallenbeck and Lewis W. Hallenbeck); (3) "Computers and Genealogy" (Theresa C. Strasser);…
Collegiate Aviation Review, 2001.
ERIC Educational Resources Information Center
Carney, Thomas Q., Ed.
2001-01-01
This issue contains these 12 papers: "Exploring the Viability of an Organizational Readiness Assessment for Participatory Management Programs in a Passenger Airline Carrier" (Al Bellamy); "Teaching the Pilots of the New Millennium: Adult Cooperative Education in Aviation Education" (Joseph F. Clark, III); "The Transfer of…
1969-09-24
Donald Hewes at Lunar Landing Research Facility (LLRF). Donald Hewes, head of the Spacecraft Research Branch, managed the facility. Piles of cinders simulated the lunar craters and terrain features. Published in the book " A Century at Langley" by Joseph Chambers. pg. 97
75 FR 57329 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus
Federal Register 2010, 2011, 2012, 2013, 2014
2010-09-20
..., Tommy S. Boden, Travis D. Bjerk, Scott L. Colson, Dustin G. Cook, Nathan J. Enloe, Stephen J. Faxon, Joseph B. Hall, Mark H. Horne, Michael J. Hurst, Chad W. Lawyer, John R. Little, Roy L. McKinney, Thomas...
Striving for the Third Place: Intercultural Competence through Language Education.
ERIC Educational Resources Information Center
Lo Bianco, Joseph, Ed.; Liddicoat, Anthony J., Ed.; Crozet, Chantal, Ed.
Essays concerning second language teaching as a means of promoting intercultural competence include: "Intercultural Competence: From Language Policy to Language Education" (Chantal Crozet, Anthony J. Liddicoat, Joseph Lo Bianco); "Linguistic Diversity, Globalisation and Intercultural Education" (Jagdish Gundara); "French…
Infrared Space Observatory (ISO) Data Analysis
NASA Technical Reports Server (NTRS)
Joseph, Robert D.; Sanders, David B.; Stockton, Alan; Hu, Esther
1999-01-01
Joseph is an ISO Co-Investigator. His Guaranteed Time Observations include both a major programme for which he is the Principal Investigator, and a number of other prgrammes in collaboration with other ISPHOT Co-Investigators, David Sanders, Alan Stockton, and Esther Hu.
Federal Register 2010, 2011, 2012, 2013, 2014
2013-04-19
... controlled substances listed in schedule II, which falls under the authority of section 1002(a)(2)(B) of the...), (d), (e), and (f) are satisfied. Dated: April 10, 2013. Joseph T. Rannazzisi, Deputy Assistant...
Phillips and Acaba work with LiOH cartridges on Middeck (MDDK)
2009-03-25
S119-E-008447 (25 March 2009) --- Astronaut John Phillips (left) and Joseph Acaba, both STS-119 mission specialists, work with the lithium hydroxide (LiOH) canisters beneath Space Shuttle Discovery's middeck during flight day 11 activities.
2012 right-of-way fatality & trespass prevention workshop
DOT National Transportation Integrated Search
2013-04-30
Based on the success of the 2008 Trespasser Workshop, FRA and FTA sponsored this follow-on workshop. The keynote speech by FRA Administrator, Mr. Joseph C. Szabo, was followed by 23 technical presentations in the areas of Pedestrian Safety, Hazard Ma...
ERIC Educational Resources Information Center
Wyman, Richard M., Jr.; Young, Katherine A.; Sliger, Bruce; Kafi, Patricia; Singer, Alan; Lamme, Linda Leonard
1998-01-01
Presents five brief articles related to middle-level learning. The articles are, "Using Children's Diaries to Teach the Oregon Trail"; "Living the Geography of Joseph and Temperance Brown"; "The ABCs of Small Grant Acquisition for Social Studies"; "Isomo Loruko: The Yoruba Naming Ceremony"; and "Child…