An Rf Focused Interdigital Ion Accelerating Structure

DOE Office of Scientific and Technical Information (OSTI.GOV)

Swenson, D.A.

2003-08-26

An Rf Focused Interdigital (RFI) ion accelerating structure will be described. It represents an effective combination of the Wideroee (or interdigital) linac structure, used for many low frequency, heavy ion applications, and the rf electric quadrupole focusing used in the RFQ and RFD linac structures. As in the RFD linac structure, rf focusing is introduced into the RFI linac structure by configuring the drift tubes as two independent pieces operating at different electrical potentials as determined by the rf fields of the linac structure. Each piece (or electrode) of the RFI drift tube supports two fingers pointed inwards towards themore » opposite end of the drift tube forming a four-finger geometry that produces an rf quadrupole field along the axis of the linac for focusing the beam. However, because of the differences in the rf field configuration along the axis, the scheme for introducing rf focusing into the interdigital linac structure is quite different from that adopted for the RFD linac structure. The RFI linac structure promises to have significant size, efficiency, performance, and cost advantages over existing linac structures for the acceleration of low energy ion beams of all masses (light to heavy). These advantages will be reviewed. A 'cold model' of this new linac structure has been fabricated and the results of rf cavity measurements on this cold model will be presented.« less

Design and Analysis of the Warm-To Suspension Links for Jefferson Lab's 11 Gev/c Super High Momentum Spectrometer

NASA Astrophysics Data System (ADS)

Sun, E.; Brindza, P.; Lassiter, S.; Fowler, M.

2010-04-01

This paper describes design and analysis performed for the warm-to-cold suspension links of the warm iron yoke superconducting quadrupole magnets, and superconducting dipole magnet. The results of investigation of titanium Ti-6Al-4V and Nitronic 50 stainless steel for the suspension links to support the cold mass, preloads, forces due to cryogenic temperature, and imbalanced magnetic forces from misalignments are presented. Allowable stresses at normal-case scenarios and worst-case scenarios, space constraints, and heat leak considerations are discussed. Principles of the ASME Pressure Vessel Code were used to determine allowable stresses. Optimal angles of the suspension links were obtained by calculation and finite element methods. The stress levels of suspension links at multiple scenarios are presented, discussed, and compared with the allowable stresses.

Planck CMB Anomalies: Astrophysical and Cosmological Secondary Effects and the Curse of Masking

NASA Astrophysics Data System (ADS)

Rassat, Anais

2016-07-01

Large-scale anomalies have been reported in CMB data with both WMAP and Planck data. These could be due to foreground residuals and or systematic effects, though their confirmation with Planck data suggests they are not due to a problem in the WMAP or Planck pipelines. If these anomalies are in fact primordial, then understanding their origin is fundamental to either validate the standard model of cosmology or to explore new physics. We investigate three other possible issues: 1) the trade-off between minimising systematics due to foreground contamination (with a conservative mask) and minimising systematics due to masking, 2) astrophysical secondary effects (the kinetic Doppler quadrupole and kinetic Sunyaev-Zel'dovich effect), and 3) secondary cosmological signals (the integrated Sachs-Wolfe effect). We address the masking issue by considering new procedures that use both WMAP and Planck to produce higher quality full-sky maps using the sparsity methodology (LGMCA maps). We show the impact of masking is dominant over that of residual foregrounds, and the LGMCA full-sky maps can be used without further processing to study anomalies. We consider four official Planck PR1 and two LGMCA CMB maps. Analysis of the observed CMB maps shows that only the low quadrupole and quadrupole-octopole alignment seem significant, but that the planar octopole, Axis of Evil, mirror parity and cold spot are not significant in nearly all maps considered. After subtraction of astrophysical and cosmological secondary effects, only the low quadrupole may still be considered anomalous, meaning the significance of only one anomaly is affected by secondary effect subtraction out of six anomalies considered. In the spirit of reproducible research all reconstructed maps and codes are available online.

Planck CMB anomalies: astrophysical and cosmological secondary effects and the curse of masking

NASA Astrophysics Data System (ADS)

Rassat, A.; Starck, J.-L.; Paykari, P.; Sureau, F.; Bobin, J.

2014-08-01

Large-scale anomalies have been reported in CMB data with both WMAP and Planck data. These could be due to foreground residuals and or systematic effects, though their confirmation with Planck data suggests they are not due to a problem in the WMAP or Planck pipelines. If these anomalies are in fact primordial, then understanding their origin is fundamental to either validate the standard model of cosmology or to explore new physics. We investigate three other possible issues: 1) the trade-off between minimising systematics due to foreground contamination (with a conservative mask) and minimising systematics due to masking, 2) astrophysical secondary effects (the kinetic Doppler quadrupole and kinetic Sunyaev-Zel'dovich effect), and 3) secondary cosmological signals (the integrated Sachs-Wolfe effect). We address the masking issue by considering new procedures that use both WMAP and Planck to produce higher quality full-sky maps using the sparsity methodology (LGMCA maps). We show the impact of masking is dominant over that of residual foregrounds, and the LGMCA full-sky maps can be used without further processing to study anomalies. We consider four official Planck PR1 and two LGMCA CMB maps. Analysis of the observed CMB maps shows that only the low quadrupole and quadrupole-octopole alignment seem significant, but that the planar octopole, Axis of Evil, mirror parity and cold spot are not significant in nearly all maps considered. After subtraction of astrophysical and cosmological secondary effects, only the low quadrupole may still be considered anomalous, meaning the significance of only one anomaly is affected by secondary effect subtraction out of six anomalies considered. In the spirit of reproducible research all reconstructed maps and codes will be made available for download here http://www.cosmostat.org/anomaliesCMB.html.

The importance of quadrupole sources in prediction of transonic tip speed propeller noise

NASA Technical Reports Server (NTRS)

Hanson, D. B.; Fink, M. R.

1978-01-01

A theoretical analysis is presented for the harmonic noise of high speed, open rotors. Far field acoustic radiation equations based on the Ffowcs-Williams/Hawkings theory are derived for a static rotor with thin blades and zero lift. Near the plane of rotation, the dominant sources are the volume displacement and the rho U(2) quadrupole, where u is the disturbance velocity component in the direction blade motion. These sources are compared in both the time domain and the frequency domain using two dimensional airfoil theories valid in the subsonic, transonic, and supersonic speed ranges. For nonlifting parabolic arc blades, the two sources are equally important at speeds between the section critical Mach number and a Mach number of one. However, for moderately subsonic or fully supersonic flow over thin blade sections, the quadrupole term is negligible. It is concluded for thin blades that significant quadrupole noise radiation is strictly a transonic phenomenon and that it can be suppressed with blade sweep. Noise calculations are presented for two rotors, one simulating a helicopter main rotor and the other a model propeller. For the latter, agreement with test data was substantially improved by including the quadrupole source term.

Silicon chemistry in interstellar clouds

NASA Technical Reports Server (NTRS)

Langer, William D.; Glassgold, A. E.

1989-01-01

Interstellar SiO was discovered shortly after CO but it has been detected mainly in high density and high temperature regions associated with outflow sources. A new model of interstellar silicon chemistry that explains the lack of SiO detections in cold clouds is presented which contains an exponential temperature dependence for the SiO abundance. A key aspect of the model is the sensitivity of SiO production by neutral silicon reactions to density and temperature, which arises from the dependence of the rate coefficients on the population of the excited fine structure levels of the silicon atom. This effect was originally pointed out in the context of neutral reactions of carbon and oxygen by Graff, who noted that the leading term in neutral atom-molecule interactions involves the quadrupole moment of the atom. Similar to the case of carbon, the requirement that Si has a quadrupole moment requires population of the J = 1 level, which lies 111K above the J = 0 ground state and has a critical density n(cr) equal to or greater than 10(6)/cu cm. The SiO abundance then has a temperature dependence proportional to exp(-111/T) and a quadratic density dependence for n less than n(cr). As part of the explanation of the lack of SiO detections at low temperatures and densities, this model also emphasizes the small efficiencies of the production routes and the correspondingly long times needed to reach equilibrium. Measurements of the abundance of SiO, in conjunction with theory, can provide information on the physical properties of interstellar clouds such as the abundances of oxygen bearing molecules and the depletion of interstellar silicon.

Solar-System Tests of Gravitational Theories

NASA Technical Reports Server (NTRS)

Shapiro, Irwin I.

2005-01-01

We are engaged in testing gravitational theory, mainly using observations of objects in the solar system and mainly on the interplanetary scale. Our goal is either to detect departures from the standard model (general relativity) - if any exist within the level of sensitivity of our data - or to support this model by placing tighter bounds on any departure from it. For this project, we have analyzed a combination of observational data with our model of the solar system, including planetary radar ranging, lunar laser ranging, and spacecraft tracking, as well as pulsar timing and pulsar VLBI measurements. In the past year, we have added to our data, primarily lunar laser ranging measurements, but also supplementary data concerning the physical properties of solar-system objects, such as the solar quadrupole moment, planetary masses, and asteroid radii. Because the solar quadrupole moment contributes to the classical precession of planetary perihelia, but with a dependence on distance from the Sun that differs from that of the relativistic precession, it is possible to estimate effects simultaneously. However, our interest is mainly in the relativistic effect, and we find that imposing a constraint on the quadrupole moment from helioseismology studies, gives us a dramatic (about ten-fold) decrease in the standard error of our estimate of the relativistic component of the perihelion advance.

Moment of inertia, quadrupole moment, Love number of neutron star and their relations with strange-matter equations of state

NASA Astrophysics Data System (ADS)

Bandyopadhyay, Debades; Bhat, Sajad A.; Char, Prasanta; Chatterjee, Debarati

2018-02-01

We investigate the impact of strange-matter equations of state involving Λ hyperons, Bose-Einstein condensate of K- mesons and first-order hadron-quark phase transition on moment of inertia, quadrupole moment and tidal deformability parameter of slowly rotating neutron stars. All these equations of state are compatible with the 2 M_{solar} constraint. The main findings of this investigation are the universality of the I- Q and I -Love number relations, which are preserved by the EoSs including Λ hyperons and antikaon condensates, but broken in the presence of a first-order hadron-quark phase transition. Furthermore, it is also noted that the quadrupole moment approaches the Kerr value of a black hole for maximum-mass neutron stars.

Variable energy constant current accelerator structure

DOEpatents

Anderson, Oscar A.

1990-01-01

A variable energy, constant current ion beam accelerator structure is disclosed comprising an ion source capable of providing the desired ions, a pre-accelerator for establishing an initial energy level, a matching/pumping module having means for focusing means for maintaining the beam current, and at least one main accelerator module for continuing beam focus, with means capable of variably imparting acceleration to the beam so that a constant beam output current is maintained independent of the variable output energy. In a preferred embodiment, quadrupole electrodes are provided in both the matching/pumping module and the one or more accelerator modules, and are formed using four opposing cylinder electrodes which extend parallel to the beam axis and are spaced around the beam at 90.degree. intervals with opposing electrodes maintained at the same potential. Adjacent cylinder electrodes of the quadrupole structure are maintained at different potentials to thereby reshape the cross section of the charged particle beam to an ellipse in cross section at the mid point along each quadrupole electrode unit in the accelerator modules. The beam is maintained in focus by alternating the major axis of the ellipse along the x and y axis respectively at adjacent quadrupoles. In another embodiment, electrostatic ring electrodes may be utilized instead of the quadrupole electrodes.

LARP Long Quadrupole: A "Long" Step Toward an LHC

ScienceCinema

Giorgio Ambrosio

2017-12-09

The beginning of the development of Nb3Sn magnets for particle accelerators goes back to the 1960’s. But only very recently has this development begun to face the challenges of fabricating Nb3Sn magnets which can meet the requirements of modern particle accelerators. LARP (the LHC Accelerator Research Program) is leading this effort focusing on long models of the Interaction Region quadrupoles for a possible luminosity upgrade of the Large Hadron Collider. A major milestone in this development is to test, by the end of 2009, 4m-long quadrupole models, which will be the first Nb3Sn accelerator-type magnets approaching the length of real accelerator magnets. The Long Quadrupoles (LQ) are “Proof-of-Principle” magnets which are to demonstrate that Nb3Sn technology is sufficiently mature for use in high energy particle accelerators. Their design is based on the LARP Technological Quadrupole (TQ) models, under development at FNAL and LBNL, which have design gradients higher than 200 T/m and an aperture of 90 mm. Several challenges must be addressed for the successful fabrication of long Nb3Sn coils and magnets. These challenges and the solutions adopted will be presented together with the main features of the LQ magnets. Several R&D lines are participating to this effort and their contributions will be also presented.

Development and application of a generic CFD toolkit covering the heat flows in combined solid-liquid systems with emphasis on the thermal design of HiLumi superconducting magnets

NASA Astrophysics Data System (ADS)

Bozza, Gennaro; Malecha, Ziemowit M.; Van Weelderen, Rob

2016-12-01

The main objective of this work is to develop a robust multi-region numerical toolkit for the modeling of heat flows in combined solid-liquid systems. Specifically heat transfer in complex cryogenic system geometries involving super-fluid helium. The incentive originates from the need to support the design of superconductive magnets in the framework of the HiLumi-LHC project (Brüning and Rossi, 2015) [1]. The intent is, instead of solving heat flows in restricted domains, to be able to model a full magnet section in one go including all relevant construction details as accurately as possible. The toolkit was applied to the so-called MQXF quadrupole magnet design. Parametrisation studies were used to find a compromise in thermal design and electro-mechanical construction constraints. The cooling performance is evaluated in terms of temperature margin of the magnets under full steady state heat load conditions and in terms of maximal sustainable load. We also present transient response to pulse heat loads of varying duration and power and the system response to time-varying cold source temperatures.

A permanent magnet trap for buffer gas cooled atoms and molecules

NASA Astrophysics Data System (ADS)

Nohlmans, D.; Skoff, S. M.; Hendricks, R. J.; Segal, D. M.; Sauer, B. E.; Hinds, E. A.; Tarbutt, M. R.

2013-05-01

Cold molecules are set to provide a wealth of new science compared to their atomic counterparts. Here we want to present preliminary results for cooling and trapping atoms/molecules in a permanent magnetic trap. By replacing the conventional buffer gas cell with an arrangement of permanent magnets, we will be able to trap a fraction of the molecules right where they are cooled. For this purpose we have designed a quadrupole trap using NdFeB magnets, which has a trap depth of 0.4 K for molecules with a magnetic moment of 1 μB. Cold helium gas is pulsed into the trap region by a solenoid valve and the atoms/molecules are subsequently ablated into this and cooled via elastic collisions, leaving a fraction of them trapped. This new set-up is currently being tested with lithium atoms as they are easier to make. After having optimised the trapping and detection processes, we will use the same trap for YbF molecules.

Seasonal variations in the profile of main phospholipids in Mytilus galloprovincialis mussels: A study by hydrophilic interaction liquid chromatography-electrospray ionization Fourier transform mass spectrometry.

PubMed

Facchini, Laura; Losito, Ilario; Cataldi, Tommaso R I; Palmisano, Francesco

2018-01-01

A systematic characterization of phosphatidylcholines and phosphatidylethanolamines in mussels of sp Mytilus galloprovincialis was performed by high-efficiency hydrophilic interaction liquid chromatography combined with electrospray ionization and Fourier transform mass spectrometry (FTMS), based on a quadrupole-Orbitrap hybrid spectrometer. The FTMS/MS experiments under high collisional energy dissociation conditions, complemented by low-energy collisionally induced dissociation MS n (n = 2,3) experiments, performed in a linear ion trap mass spectrometer, were exploited for structural elucidation purposes. The described approach led to an unprecedented characterization of the mussel phospholipidome, with 185 phosphatidylcholines and 131 phosphatidylethanolamines species recognized, distributed among diacylic, plasmanylic, and plasmenylic forms. This was the starting point for the evaluation of the effects of season (in particular, of sea temperature) on the profile of those phospholipids. To this aim, a set of mussel samples retrieved from commercial sources in different periods of the year was considered. Principal component analysis revealed a clear separation between samples collected in periods characterized by cold, intermediate, or warm sea temperatures, respectively. In particular, an enrichment in phospholipids containing unsaturated side chains was observed in mussels collected from cold seawaters (winter-early spring), thus confirming the general model previously elaborated to explain the adaptation of marine invertebrates, including some bivalve molluscs, to low temperatures. On the other hand, relevant levels of plasma(e)nylic and acylic phospholipids bearing either saturated or non-methylene-interrupted side chains were found in mussels collected in warm seawaters (typical of summer and early autumn, at Italian latitudes). This finding opened interesting perspectives towards the development of strategies able to prevent global warming-related mussel losses in aquacultural plants. Copyright © 2017 John Wiley & Sons, Ltd.

Design of an rf quadrupole for Landau damping

NASA Astrophysics Data System (ADS)

Papke, K.; Grudiev, A.

2017-08-01

The recently proposed superconducting quadrupole resonator for Landau damping in accelerators is subjected to a detailed design study. The optimization process of two different cavity types is presented following the requirements of the High Luminosity Large Hadron Collider (HL-LHC) with the main focus on quadrupolar strength, surface peak fields, and impedance. The lower order and higher order mode (LOM and HOM) spectrum of the optimized cavities is investigated and different approaches for their damping are proposed. On the basis of an example the first two higher order multipole errors are calculated. Likewise on this example the required rf power and optimal external quality factor for the input coupler is derived.

The development of magnetic field measurement system for drift-tube linac quadrupole

NASA Astrophysics Data System (ADS)

Zhou, Jianxin; Kang, Wen; Yin, Baogui; Peng, Quanling; Li, Li; Liu, Huachang; Gong, Keyun; Li, Bo; Chen, Qiang; Li, Shuai; Liu, Yiqin

2015-06-01

In the China Spallation Neutron Source (CSNS) linac, a conventional 324 MHz drift-tube linac (DTL) accelerating an H- ion beam from 3 MeV to 80 MeV has been designed and manufactured. The electromagnetic quadrupoles (EMQs) are widely used in a DTL accelerator. The main challenge of DTLQ's structure is to house a strong gradient EMQ in the much reduced space of the drift-tube (DT). To verify the DTLQ's design specifications and fabrication quality, a precision harmonic coil measurement system has been developed, which is based on the high precision movement platform, the harmonic coil with ceramic frame and the special method to make the harmonic coil and the quadrupoles coaxial. After more than one year's continuous running, the magnetic field measurement system still performs accurately and stably. The field measurement of more than one hundred DTLQ has been finished. The components and function of the measurement system, the key point of the technology and the repeatability of the measurement results are described in this paper.

Hyperfine field, electric field gradient, quadrupole coupling constant and magnetic properties of challenging actinide digallide

NASA Astrophysics Data System (ADS)

Khan, Sajid; Yazdani-Kachoei, M.; Jalali-Asadabadi, S.; Ahmad, Iftikhar

2017-12-01

In this paper, we explore the structural and magnetic properties as well as electric field gradient (EFG), hyperfine field (HFF) and quadrupole coupling constant in actinide digallide AcGa2 (Ac = U, Np, Pu) using LDA, GGA, LDA+U, GGA+U and hybrid functional with Wu-Cohen Generalized Gradient approximation HF-WC. Relativistic effects of the electrons are considered by including spin-orbit coupling. The comparison of the calculated structural parameters and magnetic properties with the available experimental results confirms the consistency and hence effectiveness of our theoretical tools. The calculated magnetic moments demonstrate that UGa2 and NpGa2 are ferromagnetic while PuGa2 is antiferromagnetic in nature. The EFG of AcGa2 is reported for the first time. The HFF, EFG and quadrupole coupling constant in AcGa2 (Ac = U, Np, Pu) are mainly originated from f-f and p-p contributions of Ac atom and p-p contribution of Ga atom.

Removal of two large-scale cosmic microwave background anomalies after subtraction of the integrated Sachs-Wolfe effect

NASA Astrophysics Data System (ADS)

Rassat, A.; Starck, J.-L.; Dupé, F.-X.

2013-09-01

Context. Although there is currently a debate over the significance of the claimed large-scale anomalies in the cosmic microwave background (CMB), their existence is not totally dismissed. In parallel to the debate over their statistical significance, recent work has also focussed on masks and secondary anisotropies as potential sources of these anomalies. Aims: In this work we investigate simultaneously the impact of the method used to account for masked regions as well as the impact of the integrated Sachs-Wolfe (ISW) effect, which is the large-scale secondary anisotropy most likely to affect the CMB anomalies. In this sense, our work is an update of previous works. Our aim is to identify trends in CMB data from different years and with different mask treatments. Methods: We reconstruct the ISW signal due to 2 Micron All-Sky Survey (2MASS) and NRAO VLA Sky Survey (NVSS) galaxies, effectively reconstructing the low-redshift ISW signal out to z ~ 1. We account for regions of missing data using the sparse inpainting technique. We test sparse inpainting of the CMB, large scale structure and ISW and find that it constitutes a bias-free reconstruction method suitable to study large-scale statistical isotropy and the ISW effect. Results: We focus on three large-scale CMB anomalies: the low quadrupole, the quadrupole/octopole alignment, and the octopole planarity. After sparse inpainting, the low quadrupole becomes more anomalous, whilst the quadrupole/octopole alignment becomes less anomalous. The significance of the low quadrupole is unchanged after subtraction of the ISW effect, while the trend amongst the CMB maps is that both the low quadrupole and the quadrupole/octopole alignment have reduced significance, yet other hypotheses remain possible as well (e.g. exotic physics). Our results also suggest that both of these anomalies may be due to the quadrupole alone. While the octopole planarity significance is reduced after inpainting and after ISW subtraction, however, we do not find that it was very anomalous to start with. In the spirit of participating in reproducible research, we make all codes and resulting products which constitute main results of this paper public here: http://www.cosmostat.org/anomaliesCMB.html

General quadrupolar statistical anisotropy: Planck limits

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ramazanov, S.; Rubtsov, G.; Thorsrud, M.

2017-03-01

Several early Universe scenarios predict a direction-dependent spectrum of primordial curvature perturbations. This translates into the violation of the statistical isotropy of cosmic microwave background radiation. Previous searches for statistical anisotropy mainly focussed on a quadrupolar direction-dependence characterised by a single multipole vector and an overall amplitude g {sub *}. Generically, however, the quadrupole has a more complicated geometry described by two multipole vectors and g {sub *}. This is the subject of the present work. In particular, we limit the amplitude g {sub *} for different shapes of the quadrupole by making use of Planck 2015 maps. We alsomore » constrain certain inflationary scenarios which predict this kind of more general quadrupolar statistical anisotropy.« less

Human whole body cold adaptation.

PubMed

Daanen, Hein A M; Van Marken Lichtenbelt, Wouter D

2016-01-01

Reviews on whole body human cold adaptation generally do not distinguish between population studies and dedicated acclimation studies, leading to confusing results. Population studies show that indigenous black Africans have reduced shivering thermogenesis in the cold and poor cold induced vasodilation in fingers and toes compared to Caucasians and Inuit. About 40,000 y after humans left Africa, natives in cold terrestrial areas seems to have developed not only behavioral adaptations, but also physiological adaptations to cold. Dedicated studies show that repeated whole body exposure of individual volunteers, mainly Caucasians, to severe cold results in reduced cold sensation but no major physiological changes. Repeated cold water immersion seems to slightly reduce metabolic heat production, while repeated exposure to milder cold conditions shows some increase in metabolic heat production, in particular non-shivering thermogenesis. In conclusion, human cold adaptation in the form of increased metabolism and insulation seems to have occurred during recent evolution in populations, but cannot be developed during a lifetime in cold conditions as encountered in temperate and arctic regions. Therefore, we mainly depend on our behavioral skills to live in and survive the cold.

Human whole body cold adaptation

PubMed Central

Daanen, Hein A.M.; Van Marken Lichtenbelt, Wouter D.

2016-01-01

ABSTRACT Reviews on whole body human cold adaptation generally do not distinguish between population studies and dedicated acclimation studies, leading to confusing results. Population studies show that indigenous black Africans have reduced shivering thermogenesis in the cold and poor cold induced vasodilation in fingers and toes compared to Caucasians and Inuit. About 40,000 y after humans left Africa, natives in cold terrestrial areas seems to have developed not only behavioral adaptations, but also physiological adaptations to cold. Dedicated studies show that repeated whole body exposure of individual volunteers, mainly Caucasians, to severe cold results in reduced cold sensation but no major physiological changes. Repeated cold water immersion seems to slightly reduce metabolic heat production, while repeated exposure to milder cold conditions shows some increase in metabolic heat production, in particular non-shivering thermogenesis. In conclusion, human cold adaptation in the form of increased metabolism and insulation seems to have occurred during recent evolution in populations, but cannot be developed during a lifetime in cold conditions as encountered in temperate and arctic regions. Therefore, we mainly depend on our behavioral skills to live in and survive the cold. PMID:27227100

Photospheric and coronal magnetic fields in six magnetographs. I. Consistent evolution of the bashful ballerina

NASA Astrophysics Data System (ADS)

Virtanen, Ilpo; Mursula, Kalevi

2016-06-01

Aims: We study the long-term evolution of photospheric and coronal magnetic fields and the heliospheric current sheet (HCS), especially its north-south asymmetry. Special attention is paid to the reliability of the six data sets used in this study and to the consistency of the results based on these data sets. Methods: We use synoptic maps constructed from Wilcox Solar Observatory (WSO), Mount Wilson Observatory (MWO), Kitt Peak (KP), SOLIS, SOHO/MDI, and SDO/HMI measurements of the photospheric field and the potential field source surface (PFSS) model. Results: The six data sets depict a fairly similar long-term evolution of magnetic fields and the heliospheric current sheet, including polarity reversals and hemispheric asymmetry. However, there are time intervals of several years long, when first KP measurements in the 1970s and 1980s, and later WSO measurements in the 1990s and early 2000s, significantly deviate from the other simultaneous data sets, reflecting likely errors at these times. All of the six magnetographs agree on the southward shift of the heliospheric current sheet (the so-called bashful ballerina phenomenon) in the declining to minimum phase of the solar cycle during a few years of the five included cycles. We show that during solar cycles 20-22, the southward shift of the HCS is mainly due to the axial quadrupole term, reflecting the stronger magnetic field intensity at the southern pole during these times. During cycle 23 the asymmetry is less persistent and mainly due to higher harmonics than the quadrupole term. Currently, in the early declining phase of cycle 24, the HCS is also shifted southward and is mainly due to the axial quadrupole as for most earlier cycles. This further emphasizes the special character of the global solar field during cycle 23.

New measurements on water ice photodesorption and product formation under ultraviolet irradiation

NASA Astrophysics Data System (ADS)

Cruz-Diaz, Gustavo A.; Martín-Doménech, Rafael; Moreno, Elena; Muñoz Caro, Guillermo M.; Chen, Yu-Jung

2018-03-01

The photodesorption of icy grain mantles has been claimed to be responsible for the abundance of gas-phase molecules towards cold regions. Being water a ubiquitous molecule, it is crucial to understand its role in photochemistry and its behaviour under an ultraviolet field. We report new measurements on the ultraviolet (UV) photodesorption of water ice and its H2, OH, and O2 photoproducts using a calibrated quadrupole mass spectrometer. Solid water was deposited under ultra-high-vacuum conditions and then UV-irradiated at various temperatures starting from 8 K with a microwave discharged hydrogen lamp. Deuterated water was used for confirmation of the results. We found a photodesorption yield of 1.3 × 10-3 molecules per incident photon for water and 0.7 × 10-3 molecules per incident photon for deuterated water at the lowest irradiation temperature, 8 K. The photodesorption yield per absorbed photon is given and comparison with astrophysical scenarios, where water ice photodesorption could account for the presence of gas-phase water towards cold regions in the absence of a thermal desorption process, is addressed.

Rapid isolation, reliable characterization, and water solubility improvement of polymethoxyflavones from cold-pressed mandarin essential oil.

PubMed

Russo, Marina; Rigano, Francesca; Arigò, Adriana; Sciarrone, Danilo; Calabrò, Maria Luisa; Farnetti, Sara; Dugo, Paola; Mondello, Luigi

2016-06-01

Polymethoxyflavones possess many biological properties, as lipid-lowering, hypoglycaemic, anti-inflammatory, antioxidant, and anticancer activities, therefore, they may be employed as nutraceuticals or therapeutic agents. The scarcity of pure polymethoxyflavones on the market as well as their low water solubility limited in vivo studies and the use of polymethoxyflavones as food or pharmaceutical supplements. Since mandarin peels are a rich source of polymethoxyflavones, tangeretin, nobiletin, sinensetin, tetra-O-methyl scutellarein, and heptamethoxyflavone were purified from a nonvolatile residue of a cold-pressed mandarin essential oil using a multidimensional preparative liquid chromatographic system coupled with a photodiode array detector and a single quadrupole mass spectrometer. A new prototype, consisting of a nano-liquid chromatography system coupled with an electron ionization mass spectrometer, was used for the characterization of the pure isolated molecules. Finally, due to the collection of highly pure nobiletin and tangeretin, the ability of 2-hydroxypropyl-β-cyclodextrin to enhance the water solubility of both polymethoxyflavones was evaluated by phase solubility studies and Job's plot method. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Continuous Quadrupole Magnetic Separation of Islets during Digestion Improves Purified Porcine Islet Viability.

PubMed

Weegman, Bradley P; Kumar Sajja, Venkata Sunil; Suszynski, Thomas M; Rizzari, Michael D; Scott Iii, William E; Kitzmann, Jennifer P; Mueller, Kate R; Hanley, Thomas R; Kennedy, David J; Todd, Paul W; Balamurugan, Appakalai N; Hering, Bernhard J; Papas, Klearchos K

2016-01-01

Islet transplantation (ITx) is an emerging and promising therapy for patients with uncontrolled type 1 diabetes. The islet isolation and purification processes require exposure to extended cold ischemia, warm-enzymatic digestion, mechanical agitation, and use of damaging chemicals for density gradient separation (DG), all of which reduce viable islet yield. In this paper, we describe initial proof-of-concept studies exploring quadrupole magnetic separation (QMS) of islets as an alternative to DG to reduce exposure to these harsh conditions. Three porcine pancreata were split into two parts, the splenic lobe (SPL) and the combined connecting/duodenal lobes (CDL), for paired digestions and purifications. Islets in the SPL were preferentially labeled using magnetic microparticles (MMPs) that lodge within the islet microvasculature when infused into the pancreas and were continuously separated from the exocrine tissue by QMS during the collection phase of the digestion process. Unlabeled islets from the CDL were purified by conventional DG. Islets purified by QMS exhibited significantly improved viability (measured by oxygen consumption rate per DNA, p < 0.03) and better morphology relative to control islets. Islet purification by QMS can reduce the detrimental effects of prolonged exposure to toxic enzymes and density gradient solutions and substantially improve islet viability after isolation.

Continuous Quadrupole Magnetic Separation of Islets during Digestion Improves Purified Porcine Islet Viability

PubMed Central

Kumar Sajja, Venkata Sunil; Rizzari, Michael D.; Scott III, William E.; Kitzmann, Jennifer P.; Kennedy, David J.; Todd, Paul W.; Balamurugan, Appakalai N.; Hering, Bernhard J.

2016-01-01

Islet transplantation (ITx) is an emerging and promising therapy for patients with uncontrolled type 1 diabetes. The islet isolation and purification processes require exposure to extended cold ischemia, warm-enzymatic digestion, mechanical agitation, and use of damaging chemicals for density gradient separation (DG), all of which reduce viable islet yield. In this paper, we describe initial proof-of-concept studies exploring quadrupole magnetic separation (QMS) of islets as an alternative to DG to reduce exposure to these harsh conditions. Three porcine pancreata were split into two parts, the splenic lobe (SPL) and the combined connecting/duodenal lobes (CDL), for paired digestions and purifications. Islets in the SPL were preferentially labeled using magnetic microparticles (MMPs) that lodge within the islet microvasculature when infused into the pancreas and were continuously separated from the exocrine tissue by QMS during the collection phase of the digestion process. Unlabeled islets from the CDL were purified by conventional DG. Islets purified by QMS exhibited significantly improved viability (measured by oxygen consumption rate per DNA, p < 0.03) and better morphology relative to control islets. Islet purification by QMS can reduce the detrimental effects of prolonged exposure to toxic enzymes and density gradient solutions and substantially improve islet viability after isolation. PMID:27843954

Damping of spin-dipole mode and generation of quadrupole mode excitations in a spin-orbit coupled Bose-Einstein condensate

NASA Astrophysics Data System (ADS)

Li, Chuan-Hsun; Blasing, David; Chen, Yong

2017-04-01

In cold atom systems, spin excitations have been shown to be a sensitive probe of interactions and quantum statistical effects, and can be used to study spin transport in both Fermi and Bose gases. In particular, spin-dipole mode (SDM) is a type of excitation that can generate a spin current without a net mass current. We present recent measurements and analysis of SDM in a disorder-free, interacting three-dimensional (3D) 87Rb Bose-Einstein condensate (BEC) by applying spin-dependent synthetic electric fields to actuate head-on collisions between two BECs of different spin states. We experimentally study and compare the behaviors of the system following SDM excitations in the presence as well as absence of synthetic 1D spin-orbit coupling (SOC). We find that in the absence of SOC, SDM is relatively weakly damped, accompanied with collision-induced thermalization which heats up the atomic cloud. However, in the presence of SOC, we find that SDM is more strongly damped with reduced thermalization, and observe excitation of a quadrupole mode that exhibits BEC shape oscillation even after SDM is damped out. Such a mode conversion bears analogies with the Beliaev coupling process or the parametric frequency down conversion of light in nonlinear optics.

Use of liquid chromatography hybrid triple-quadrupole mass spectrometry for the detection of emodin metabolites in rat bile and urine.

PubMed

Wu, Songyan; Zhang, Yaqing; Zhang, Zunjian; Song, Rui

2017-10-01

Emodin is the representative form of rhubarb, which is widely used in traditional Chinese medicine for the treatment of purgative, anti-inflammatory, antioxidative and antiviral, etc. Previous reports demonstrated that emodin glucuronide was the major metabolite in plasma. Owing to the extensive conjugation reactions of polyphenols, the aim of this study was to identify the metabolites of emodin in rat bile and urine. Neutral loss and precursor ion scan methods of triple-quadrupole mass spectrometer revealed 13 conjugated metabolites in rat bile and 22 metabolites in rat urine, which included four phase I and 18 phase II metabolites. The major metabolites in rat biosamples were emodin glucuronoconjugates. Moreover, rhein monoglucuronide, chrysophanol monoglucuronide and rhein sulfate were proposed for the first time after oral administration of emodin. Overall, liquid chromatography hybrid triple-quadrupole mass spectrometry analysis leads to the discovery of several novel emodin metabolites in rat bile and urine and underscores that conjugated with glucuronic acid is the main metabolic pathway. Copyright © 2017 John Wiley & Sons, Ltd.

Analysis of human plasma lipids by using comprehensive two-dimensional gas chromatography with dual detection and with the support of high-resolution time-of-flight mass spectrometry for structural elucidation.

PubMed

Salivo, Simona; Beccaria, Marco; Sullini, Giuseppe; Tranchida, Peter Q; Dugo, Paola; Mondello, Luigi

2015-01-01

The main focus of the present research is the analysis of the unsaponifiable lipid fraction of human plasma by using data derived from comprehensive two-dimensional gas chromatography with dual quadrupole mass spectrometry and flame ionization detection. This approach enabled us to attain both mass spectral information and analyte percentage data. Furthermore, gas chromatography coupled with high-resolution time-of-flight mass spectrometry was used to increase the reliability of identification of several unsaponifiable lipid constituents. The synergism between both the high-resolution gas chromatography and mass spectrometry processes enabled us to attain a more in-depth knowledge of the unsaponifiable fraction of human plasma. Additionally, information was attained on the fatty acid and triacylglycerol composition of the plasma samples, subjected to investigation by using comprehensive two-dimensional gas chromatography with dual quadrupole mass spectrometry and flame ionization detection and high-performance liquid chromatography with atmospheric pressure chemical ionization quadrupole mass spectrometry, respectively. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Characterization of goat colostrum oligosaccharides by nano-liquid chromatography on chip quadrupole time-of-flight mass spectrometry and hydrophilic interaction liquid chromatography-quadrupole mass spectrometry

PubMed Central

Martín-Ortiz, A.; Salcedo, J.; Barile, D.; Bunyatratchata, A.; Moreno, F.J.; Martin-García, I.; Clemente, A.; Sanz, M.L.; Ruiz-Matute, A.I.

2016-01-01

A detailed qualitative and quantitative characterization of goat colostrum oligosaccharides (GCO) has been carried out for the first time. Defatted and deproteinized colostrum samples, previously treated by size exclusion chromatography (SEC) to remove lactose, were analyzed by nanoflow liquid chromatography-quadrupole-time of flight mass spectrometry (Nano-LC-Chip-Q-TOF MS). Up to 78 oligosaccharides containing hexose, hexosamine, fucose, N-acetylneuraminic acid or N-glycolylneuraminic acid monomeric units were identified in the samples, some of them detected for the first time in goat colostra. As a second step, a hydrophilic interaction liquid chromatography coupled to mass spectrometry (HILIC-MS) methodology was developed for the separation and quantitation of the main GCO, both acidic and neutral carbohydrates. Among other experimental chromatographic conditions, mobile phase additives and column temperature were evaluated in terms of retention time, resolution, peak width and symmetry of target carbohydrates. Narrow peaks (wh: 0.2–0.6 min) and good symmetry (As: 0.8–1.4) were obtained for GCO using an acetonitrile:water gradient with 0.1% ammonium hydroxide at 40 °C. These conditions were selected to quantify the main oligosaccharides in goat colostrum samples. Values ranging from 140 to 315 mg L−1 for neutral oligosaccharides and from 83 to 251 mg L−1 for acidic oligosaccharides were found. The combination of both techniques resulted to be useful to achieve a comprehensive characterization of GCO. PMID:26427327

Production of cold beams of ND{sub 3} with variable rotational state distributions by electrostatic extraction of He and Ne buffer-gas-cooled beams

DOE Office of Scientific and Technical Information (OSTI.GOV)

Twyman, Kathryn S.; Bell, Martin T.; Heazlewood, Brianna R.

2014-07-14

The measurement of the rotational state distribution of a velocity-selected, buffer-gas-cooled beam of ND{sub 3} is described. In an apparatus recently constructed to study cold ion-molecule collisions, the ND{sub 3} beam is extracted from a cryogenically cooled buffer-gas cell using a 2.15 m long electrostatic quadrupole guide with three 90° bends. (2+1) resonance enhanced multiphoton ionization spectra of molecules exiting the guide show that beams of ND{sub 3} can be produced with rotational state populations corresponding to approximately T{sub rot} = 9–18 K, achieved through manipulation of the temperature of the buffer-gas cell (operated at 6 K or 17 K),more » the identity of the buffer gas (He or Ne), or the relative densities of the buffer gas and ND{sub 3}. The translational temperature of the guided ND{sub 3} is found to be similar in a 6 K helium and 17 K neon buffer-gas cell (peak kinetic energies of 6.92(0.13) K and 5.90(0.01) K, respectively). The characterization of this cold-molecule source provides an opportunity for the first experimental investigations into the rotational dependence of reaction cross sections in low temperature collisions.« less

The compensation of quadrupole errors and space charge effects by using trim quadrupoles

NASA Astrophysics Data System (ADS)

An, YuWen; Wang, Sheng

2011-12-01

The China Spallation Neutron Source (CSNS) accelerators consist of an H-linac and a proton Rapid Cycling Synchrotron (RCS). RCS is designed to accumulate and accelerate proton beam from 80 MeV to 1.6 GeV with a repetition rate of 25 Hz. The main dipole and quadruple magnet will operate in AC mode. Due to the adoption of the resonant power supplies, saturation errors of magnetic field cannot be compensated by power supplies. These saturation errors will disturb the linear optics parameters, such as tunes, beta function and dispersion function. The strong space charge effects will cause emittance growth. The compensation of these effects by using trim quadruples is studied, and the corresponding results are presented.

Wavelet signatures of K-splitting of the Isoscalar Giant Quadrupole Resonance in deformed nuclei from high-resolution (p,p‧) scattering off 146, 148, 150Nd

NASA Astrophysics Data System (ADS)

Kureba, C. O.; Buthelezi, Z.; Carter, J.; Cooper, G. R. J.; Fearick, R. W.; Förtsch, S. V.; Jingo, M.; Kleinig, W.; Krugmann, A.; Krumbolz, A. M.; Kvasil, J.; Mabiala, J.; Mira, J. P.; Nesterenko, V. O.; von Neumann-Cosel, P.; Neveling, R.; Papka, P.; Reinhard, P.-G.; Richter, A.; Sideras-Haddad, E.; Smit, F. D.; Steyn, G. F.; Swartz, J. A.; Tamii, A.; Usman, I. T.

2018-04-01

The phenomenon of fine structure of the Isoscalar Giant Quadrupole Resonance (ISGQR) has been studied with high energy-resolution proton inelastic scattering at iThemba LABS in the chain of stable even-mass Nd isotopes covering the transition from spherical to deformed ground states. A wavelet analysis of the background-subtracted spectra in the deformed 146, 148, 150Nd isotopes reveals characteristic scales in correspondence with scales obtained from a Skyrme RPA calculation using the SVmas10 parameterization. A semblance analysis shows that these scales arise from the energy shift between the main fragments of the K = 0 , 1 and K = 2 components.

Dominant Overall Chemical Reaction in a Chlorine Trifluoride Silicon Nitrogen System at Atmospheric Pressure

NASA Astrophysics Data System (ADS)

Habuka, Hitoshi; Otsuka, Toru; Qu, Wei-Feng

1999-11-01

This study evaluates the overall chemical reaction in a chlorine trifluoride silicon nitrogen system at atmospheric pressure, based on the observation of the dominant chemical species in the gas phase using a quadrupole mass spectra analyzer coupled with a horizontal cold-wall single-wafer epitaxial reactor. Chlorine trifluoride gas etches the silicon surface, producing two major products, silicon tetrafluoride gas and chlorine gas, at room temperature and 530 K. The production of chlorosilanes was not observed in this study. The results obtained in this study indicate that the dominant overall chemical reaction in a chlorine trifluoride silicon nitrogen system is 3Si + 4ClF3 →3SiF4 ↑+ 2Cl2 ↑.

Larp Nb3Sn Quadrupole Magnets for the Lhc Luminosity Upgrade

NASA Astrophysics Data System (ADS)

Ferracin, P.

2010-04-01

The US LHC Accelerator Research Program (LARP) is a collaboration between four US laboratories (BNL, FNAL, LBNL, and SLAC) aimed at contributing to the commissioning and operation of the LHC and conducting R&D on its luminosity upgrade. Within LARP, the Magnet Program's main goal is to demonstrate that Nb3Sn superconducting magnets are a viable option for a future upgrade of the LHC Interaction Regions. Over the past four years, LARP has successfully fabricated and tested several R&D magnets: 1) the subscale quadrupole magnet SQ, to perform technology studies with 300 mm long racetrack coils, 2) the technology quadrupole TQ, to investigate support structure behavior with 1 m long cos 2θ coils, and 3) the long racetrack magnet LR, to test 3.6 m long racetrack coils. The next milestone consists in the fabrication and test of the 3.7 m long quadrupole magnet LQ, with the goal of demonstrating that Nb3Sn technology is mature for use in high energy accelerators. After an overview of design features and test result of the LARP magnets fabricated so far, this paper focuses on the status of the fabrication of LQ: we describe the production of the 3.4 m long cos 2θ coils, and the of the qualification support structure. Finally, the status of the development of the next 1 m long model HQ, conceived to explore stress and field limits of Nb3Sn superconducting, magnets, is presented.

Development of a radio-frequency quadrupole cooler for high beam currents

NASA Astrophysics Data System (ADS)

Boussaid, Ramzi; Ban, G.; Quéméner, G.; Merrer, Y.; Lorry, J.

2017-12-01

The SHIRaC prototype is a recently developed radio-frequency quadrupole (RFQ) beam cooler with an improved optics design to deliver the required beam quality to a high resolution separator (HRS). For an isobaric separation of isotopes, the HRS demands beams with emittance not exceeding 3 π mm mrad and longitudinal energy spread ˜1 eV . Simulation studies showed a significant contribution of the buffer gas diffusion, space charge effect and mainly the rf fringe field to degrade the achieved beam quality at the RFQ exit. A miniature rf quadrupole (μ RFQ ) has been implemented at that exit to remove the degrading effects and provide beams with 1 eV of energy spread and around 1.75 π mm mrad of emittance for 4 Pa gas pressure. This solution enables also to transmit more than 60% of the incoming ions for currents up to 1 μ A . Detailed studies of this development are presented and discussed in this paper. Transport of beams from SHIRaC towards the HRS has been done with an electrostatic quadrupole triplet. Simulations and first experimental tests showed that more than 95% of ions can reach the HRS. Because SPIRAL-2 beams are of high current and very radioactive, the buffer gas will be highly contaminated. Safe maintenance of the SHIRaC beam line needs exceptional treatment of radioactive contaminants. For that, special vinyl sleep should be mounted on elements to be maintained. A detailed maintenance process will be presented.

Development of MQXF: The Nb 3Sn low-β quadrupole for the HiLumi LHC

DOE PAGES

Ferracin, P.; G. Ambrosio; Anerella, M.; ...

2015-12-18

The High Luminosity (HiLumi) Large Hadron Collider (LHC) project has, as the main objective, to increase the LHC peak luminosity by a factor five and the integrated luminosity by a factor ten. This goal will be achieved mainly with a new interaction region layout, which will allow a stronger focusing of the colliding beams. The target will be to reduce the beam size in the interaction points by a factor of two, which requires doubling the aperture of the low-β (or inner triplet) quadrupole magnets. The use of Nb3Sn superconducting material and, as a result, the possibility of operating atmore » magnetic field levels in the windings higher than 11 T will limit the increase in length of these quadrupoles, called MQXF, to acceptable levels. After the initial design phase, where the key parameters were chosen and the magnet's conceptual design finalized, the MQXF project, a joint effort between the U.S. LHC Accelerator Research Program and the Conseil Europeen pour la Recherche Nucleaire (CERN), has now entered the construction and test phase of the short models. Concurrently, the preparation for the development of the full-length prototypes has been initiated. Lastly, this paper will provide an overview of the project status, describing and reporting on the performance of the superconducting material, the lessons learnt during the fabrication of superconducting coils and support structure, and the fine tuning of the magnet design in view of the start of the prototyping phase.« less

Characterization of goat colostrum oligosaccharides by nano-liquid chromatography on chip quadrupole time-of-flight mass spectrometry and hydrophilic interaction liquid chromatography-quadrupole mass spectrometry.

PubMed

Martín-Ortiz, A; Salcedo, J; Barile, D; Bunyatratchata, A; Moreno, F J; Martin-García, I; Clemente, A; Sanz, M L; Ruiz-Matute, A I

2016-01-08

A detailed qualitative and quantitative characterization of goat colostrum oligosaccharides (GCO) has been carried out for the first time. Defatted and deproteinized colostrum samples, previously treated by size exclusion chromatography (SEC) to remove lactose, were analyzed by nanoflow liquid chromatography-quadrupole-time of flight mass spectrometry (Nano-LC-Chip-Q-TOF MS). Up to 78 oligosaccharides containing hexose, hexosamine, fucose, N-acetylneuraminic acid or N-glycolylneuraminic acid monomeric units were identified in the samples, some of them detected for the first time in goat colostra. As a second step, a hydrophilic interaction liquid chromatography coupled to mass spectrometry (HILIC-MS) methodology was developed for the separation and quantitation of the main GCO, both acidic and neutral carbohydrates. Among other experimental chromatographic conditions, mobile phase additives and column temperature were evaluated in terms of retention time, resolution, peak width and symmetry of target carbohydrates. Narrow peaks (wh: 0.2-0.6min) and good symmetry (As: 0.8-1.4) were obtained for GCO using an acetonitrile:water gradient with 0.1% ammonium hydroxide at 40°C. These conditions were selected to quantify the main oligosaccharides in goat colostrum samples. Values ranging from 140 to 315mgL(-1) for neutral oligosaccharides and from 83 to 251mgL(-1) for acidic oligosaccharides were found. The combination of both techniques resulted to be useful to achieve a comprehensive characterization of GCO. Copyright © 2015 Elsevier B.V. All rights reserved.

Single-pass beam measurements for the verification of the LHC magnetic model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Calaga, R.; Giovannozzi, M.; Redaelli, S.

2010-05-23

During the 2009 LHC injection tests, the polarities and effects of specific quadrupole and higher-order magnetic circuits were investigated. A set of magnet circuits had been selected for detailed investigation based on a number of criteria. On or off-momentum difference trajectories launched via appropriate orbit correctors for varying strength settings of the magnet circuits under study - e.g. main, trim and skew quadrupoles; sextupole families and spool piece correctors; skew sextupoles, octupoles - were compared with predictions from various optics models. These comparisons allowed confirming or updating the relative polarity conventions used in the optics model and the accelerator controlmore » system, as well as verifying the correct powering and assignment of magnet families. Results from measurements in several LHC sectors are presented.« less

Fast analysis of triterpenoids in Ganoderma lucidum spores by ultra-performance liquid chromatography coupled with triple quadrupole mass spectrometry.

PubMed

Yan, Zhou; Xia, Bing; Qiu, Ming Hua; Li Sheng, Ding; Xu, Hong Xi

2013-11-01

A rapid and reliable method was established for simultaneous determination of main triterpenoids in Ganoderma lucidum spores using ultra-high-performance liquid chromatography coupled with triple quadrupole mass spectrometry (UPLC-TQ-MS). The established method was validated in terms of linearity, sensitivity, precision, accuracy and stability, and was successfully applied to determine the contents of 10 main triterpenoids in different batches of G. lucidum spores. The analysis results showed that moderate levels of triterpenoids were found in G. lucidum spores. In addition, a MS full scan with a daughter ion scan experiment was performed to identify the potential derivatives of triterpenoids present in G. lucidum spores. As a result, a total of 22 triterpenoids from different G. lucidum spores were unequivocally or tentatively identified via comparisons with authentic standards and literatures. This method provides both qualitative and quantitative results without the need for repetitive UPLC-MS analyses, thereby increasing efficiency and productivity, making it suitable for high-throughput applications. Copyright © 2013 John Wiley & Sons, Ltd.

A review of the use of Al-alloy vacuum components for operation at 10-13 Torr

NASA Astrophysics Data System (ADS)

Ishimaru, Hajime

1990-02-01

An extremely high vacuum (XHV) chamber was fabricated and tested. The vacuum chamber was made of special surface finished (EX-process) aluminum alloy in oxygen and argon atmosphere. The chamber was assembled using TIG welding in an argon atmosphere and by electron beam welding. The system was evacuated with a turbo-backed 300 l/s turbomolecular pump separated from the main chamber using a right angle valve. The liquid nitrogen shroud is installed inside the main vacuum chamber. The XHV is maintained by two 300 l/s sputter ion pumps and a titanium sublimation pump with a liquid nitrogen shroud. These pumps are also made of aluminum alloys. An ultimate pressure of 3×10-13 Torr was measured with a point collector gauge with a spherical anode mounted on an Al-flange. Residual gas analysis in the order 10-13 Torr was performed by a newly developed Q-mass filter. To suppress outgassing from the quadrupole electrode, the ion source is mounted on an Al-flange separated from the quadrupole electrode.

Treatment of Common Cold Patients with the Shi-Cha Capsule: A Multicenter, Double-Blind, Randomized, Placebo-Controlled, Dose-Escalation Trial

PubMed Central

Chang, Jing; Dong, Shou-Jin; She, Bin; Zhang, Rui-Ming; Meng, Mao-Bin; Xu, Yan-Ling; Wan, Li-Ling; Shi, Ke-Hua; Pan, Jun-Hun; Mao, Bing

2012-01-01

This study was designed to determine the therapeutic efficacy and safety of the Shi-cha capsule, a Chinese herbal formula, in the treatment of patients with wind-cold type common cold. In our multi-center, prospective, double-blind, randomized, placebo-controlled, dose-escalation trial, patients with wind-cold type common cold received 0.6 g of Shi-cha capsule plus 0.6 g placebo (group A), 1.2 g of Shi-cha capsule (group B), or 1.2 g placebo (group C), three times daily for 3 days and followed up to 10 days. The primary end point was all symptom duration. The secondary end points were main symptom duration, minor symptom duration, the changes in cumulative symptom score, main symptom score, and minor symptom score 4 days after the treatment, as well as adverse events. A total of 377 patients were recruited and 360 met the inclusive criteria; 120 patients constituted each treatment group. Compared with patients in group C, patients in groups A and B had significant improvement in the all symptom duration, main symptom duration, minor symptom duration, as well as change from baseline of cumulative symptom score, main symptom score, and minor symptom score at day 4. The symptom durations and scores showed slight superiority of group B over group A, although these differences were not statistically significant. There were no differences in adverse events. The Shi-cha capsule is efficacious and safe for the treatment of patients with wind-cold type common cold. Larger trials are required to fully assess the benefits and safety of this treatment for common cold. PMID:23346193

N2 Gas Flushing Alleviates the Loss of Bacterial Diversity and Inhibits Psychrotrophic Pseudomonas during the Cold Storage of Bovine Raw Milk.

PubMed

Gschwendtner, Silvia; Alatossava, Tapani; Kublik, Susanne; Fuka, Mirna Mrkonjić; Schloter, Michael; Munsch-Alatossava, Patricia

2016-01-01

The quality and safety of raw milk still remains a worldwide challenge. Culture-dependent methods indicated that the continuous N2 gas-flushing of raw milk reduced the bacterial growth during cold storage by up to four orders of magnitude, compared to cold storage alone. This study investigated the influence of N2 gas-flushing on bacterial diversity in bovine raw-milk samples, that were either cold stored at 6°C or additionally flushed with pure N2 for up to one week. Next-generation sequencing (NGS) of the V1-V2 hypervariable regions of 16S rRNA genes, derived from amplified cDNA, which was obtained from RNA directly isolated from raw-milk samples, was performed. The reads, which were clustered into 2448 operational taxonomic units (OTUs), were phylogenetically classified. Our data revealed a drastic reduction in the diversity of OTUs in raw milk during cold storage at 6°C at 97% similarity level; but, the N2-flushing treatment alleviated this reduction and substantially limited the loss of bacterial diversity during the same cold-storage period. Compared to cold-stored milk, the initial raw-milk samples contained less Proteobacteria (mainly Pseudomonadaceae, Moraxellaceae and Enterobacteriaceae) but more Firmicutes (mainly Ruminococcaceaea, Lachnospiraceae and Oscillospiraceaea) and Bacteroidetes (mainly Bacteroidales). Significant differences between cold-stored and additionally N2-flushed milk were mainly related to higher levels of Pseudomononadaceae (including the genera Pseudomonas and Acinetobacter) in cold-stored milk samples; furthermore, rare taxa were better preserved by the N2 gas flushing compared to the cold storage alone. No major changes in bacterial composition with time were found regarding the distribution of the major 9 OTUs, that dominated the Pseudomonas genus in N2-flushed or non-flushed milk samples, other than an intriguing predominance of bacteria related to P. veronii. Overall, this study established that neither bacteria causing milk spoilage nor any well-known human pathogen or anaerobe benefited from the N2 gas flushing even though the N2-flushed and non-flushed cold-stored milk differed in bacterial counts by up to 104-fold.

N2 Gas Flushing Alleviates the Loss of Bacterial Diversity and Inhibits Psychrotrophic Pseudomonas during the Cold Storage of Bovine Raw Milk

PubMed Central

Kublik, Susanne; Fuka, Mirna Mrkonjić; Schloter, Michael; Munsch-Alatossava, Patricia

2016-01-01

The quality and safety of raw milk still remains a worldwide challenge. Culture-dependent methods indicated that the continuous N2 gas-flushing of raw milk reduced the bacterial growth during cold storage by up to four orders of magnitude, compared to cold storage alone. This study investigated the influence of N2 gas-flushing on bacterial diversity in bovine raw-milk samples, that were either cold stored at 6°C or additionally flushed with pure N2 for up to one week. Next-generation sequencing (NGS) of the V1-V2 hypervariable regions of 16S rRNA genes, derived from amplified cDNA, which was obtained from RNA directly isolated from raw-milk samples, was performed. The reads, which were clustered into 2448 operational taxonomic units (OTUs), were phylogenetically classified. Our data revealed a drastic reduction in the diversity of OTUs in raw milk during cold storage at 6°C at 97% similarity level; but, the N2-flushing treatment alleviated this reduction and substantially limited the loss of bacterial diversity during the same cold-storage period. Compared to cold-stored milk, the initial raw-milk samples contained less Proteobacteria (mainly Pseudomonadaceae, Moraxellaceae and Enterobacteriaceae) but more Firmicutes (mainly Ruminococcaceaea, Lachnospiraceae and Oscillospiraceaea) and Bacteroidetes (mainly Bacteroidales). Significant differences between cold-stored and additionally N2-flushed milk were mainly related to higher levels of Pseudomononadaceae (including the genera Pseudomonas and Acinetobacter) in cold-stored milk samples; furthermore, rare taxa were better preserved by the N2 gas flushing compared to the cold storage alone. No major changes in bacterial composition with time were found regarding the distribution of the major 9 OTUs, that dominated the Pseudomonas genus in N2-flushed or non-flushed milk samples, other than an intriguing predominance of bacteria related to P. veronii. Overall, this study established that neither bacteria causing milk spoilage nor any well-known human pathogen or anaerobe benefited from the N2 gas flushing even though the N2-flushed and non-flushed cold-stored milk differed in bacterial counts by up to 104-fold. PMID:26730711

Laboratory Anion Chemistry: Implications for the DIBs, and a Potential Formation Mechanism for a Known Interstellar Molecule

NASA Technical Reports Server (NTRS)

Eichelberger, B.; Barckholtz, C.; Stepanovic, M.; Bierbaum, V.; Snow, T.

2002-01-01

Due to recent interest in molecular anions as possible interstellar species, we have carried out several laboratory studies of anion chemistry. The reactions of the series C(sub n)(sup -); and C(sub n)H(sup -) with H and H2 were studied to address the viability of such species in the diffuse interstellar medium and to address their ability to be carriers of the diffuse interstellar bands (DIBs). These same molecules were also reacted with N and O to show possible heteroatomic products. C(sub m)N(sup - was a particularly stable product from the reaction of C(sub n)(sup -) + N. C3N(sup -) was further reacted with H to study chemistry that could produce HC3N, a known interstellar species. The reactions were done in a flowing afterglow selected ion flow tube apparatus (FA-SIFT). The anions were generated in an electron impact or cold cathode discharge source and the anion of interest was then selected by a quadrupole mass filter. The selected ion was then reacted with the atomic or molecular species in the flow tube and products were detected by another quadrupole. While the C(sub n)(sup -) species do not appear to be viable DIB carriers, their possible presence could provide a mechanism for the formation of known heteroatomic neutral molecules detected in the interstellar medium (ISM).

Local properties of the large-scale peaks of the CMB temperature

DOE Office of Scientific and Technical Information (OSTI.GOV)

Marcos-Caballero, A.; Martínez-González, E.; Vielva, P., E-mail: marcos@ifca.unican.es, E-mail: martinez@ifca.unican.es, E-mail: vielva@ifca.unican.es

2017-05-01

In the present work, we study the largest structures of the CMB temperature measured by Planck in terms of the most prominent peaks on the sky, which, in particular, are located in the southern galactic hemisphere. Besides these large-scale features, the well-known Cold Spot anomaly is included in the analysis. All these peaks would contribute significantly to some of the CMB large-scale anomalies, as the parity and hemispherical asymmetries, the dipole modulation, the alignment between the quadrupole and the octopole, or in the case of the Cold Spot, to the non-Gaussianity of the field. The analysis of the peaks ismore » performed by using their multipolar profiles, which characterize the local shape of the peaks in terms of the discrete Fourier transform of the azimuthal angle. In order to quantify the local anisotropy of the peaks, the distribution of the phases of the multipolar profiles is studied by using the Rayleigh random walk methodology. Finally, a direct analysis of the 2-dimensional field around the peaks is performed in order to take into account the effect of the galactic mask. The results of the analysis conclude that, once the peak amplitude and its first and second order derivatives at the centre are conditioned, the rest of the field is compatible with the standard model. In particular, it is observed that the Cold Spot anomaly is caused by the large value of curvature at the centre.« less

Performance of Superconducting Magnet Prototypes for LCLS-II Linear Accelerator

DOE PAGES

Kashikhin, Vladimir; Andreev, Nikolai; DiMarco, Joseph; ...

2017-01-05

The new LCLS-II Linear Superconducting Accelerator at SLAC needs superconducting magnet packages installed inside SCRF Cryomodules to focus and steer an electron beam. Two magnet prototypes were built and successfully tested at Fermilab. Magnets have an iron dominated configuration, quadrupole and dipole NbTi superconducting coils, and splittable in the vertical plane configuration. Magnets inside the Cryomodule are conductively cooled through pure Al heat sinks. Both magnets performance was verified by magnetic measurements at room temperature, and during cold tests in liquid helium. Test results including magnetic measurements are discussed. Special attention was given to the magnet performance at low currentsmore » where the iron yoke and the superconductor hysteresis effects have large influence. Both magnet prototypes were accepted for the installation in FNAL and JLAB prototype Cryomodules.« less

Environmental monitors in the Midcourse Space Experiments (MSX)

NASA Technical Reports Server (NTRS)

Uy, O. M.

1993-01-01

The Midcourse Space Experiment (MSX) is an SDIO sponsored space based sensor experiment with a full complement of optical sensors. Because of the possible deleterious effect of both molecular and particulate contamination on these sensors, a suite of environmental monitoring instruments are also being flown with the spacecraft. These instruments are the Total Pressure Sensor based on the cold-cathode gauge, a quadrupole mass spectrometer, a Bennett-type ion mass spectrometer, a cryogenic quartz crystal microbalance (QCM), four temperature-controlled QCM's, and a Xenon and Krypton Flash Lamp Experiment. These instruments have been fully space-qualified, are compact and low cost, and are possible candidate sensors for near-term planetary and atmospheric monitoring. The philosophy adopted during design and fabrication, calibration and ground testing, and modeling will be discussed .

Weak quadrupole moments

NASA Astrophysics Data System (ADS)

Lackenby, B. G. C.; Flambaum, V. V.

2018-07-01

We introduce the weak quadrupole moment (WQM) of nuclei, related to the quadrupole distribution of the weak charge in the nucleus. The WQM produces a tensor weak interaction between the nucleus and electrons and can be observed in atomic and molecular experiments measuring parity nonconservation. The dominating contribution to the weak quadrupole is given by the quadrupole moment of the neutron distribution, therefore, corresponding experiments should allow one to measure the neutron quadrupoles. Using the deformed oscillator model and the Schmidt model we calculate the quadrupole distributions of neutrons, Q n , the WQMs, {Q}W(2), and the Lorentz invariance violating energy shifts in 9Be, 21Ne, 27Al, 131Xe, 133Cs, 151Eu, 153Eu, 163Dy, 167Er, 173Yb, 177Hf, 179Hf, 181Ta, 201Hg and 229Th.

Ground-state and pairing-vibrational bands with equal quadrupole collectivity in 124Xe

NASA Astrophysics Data System (ADS)

Radich, A. J.; Garrett, P. E.; Allmond, J. M.; Andreoiu, C.; Ball, G. C.; Bianco, L.; Bildstein, V.; Chagnon-Lessard, S.; Cross, D. S.; Demand, G. A.; Diaz Varela, A.; Dunlop, R.; Finlay, P.; Garnsworthy, A. B.; Hackman, G.; Hadinia, B.; Jigmeddorj, B.; Laffoley, A. T.; Leach, K. G.; Michetti-Wilson, J.; Orce, J. N.; Rajabali, M. M.; Rand, E. T.; Starosta, K.; Sumithrarachchi, C. S.; Svensson, C. E.; Triambak, S.; Wang, Z. M.; Wood, J. L.; Wong, J.; Williams, S. J.; Yates, S. W.

2015-04-01

The nuclear structure of 124Xe has been investigated via measurements of the β+/EC decay of 124Cs with the 8 π γ -ray spectrometer at the TRIUMF-ISAC facility. The data collected have enabled branching ratio measurements of weak, low-energy transitions from highly excited states, and the 2+→0+ in-band transitions have been observed. Combining these results with those from a previous Coulomb excitation study, B (E 2 ;23+→02+) =78 (13 ) W.u. and B (E 2 ;24+→03+) =53 (12 ) W.u. were determined. The 03+ state, in particular, is interpreted as the main fragment of the proton-pairing vibrational band identified in a previous 122Te (3He,n )124Xe measurement, and has quadrupole collectivity equal to, within uncertainty, that of the ground-state band.

Eight piece quadrupole magnet, method for aligning quadrupole magent pole tips

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jaski, Mark S.; Liu, Jie; Donnelly, Aric T.

The invention provides an alternative to the standard 2-piece or 4-piece quadrupole. For example, an 8-piece and a 10-piece quadrupole are provided whereby the tips of each pole may be adjustable. Also provided is a method for producing a quadrupole using standard machining techniques but which results in a final tolerance accuracy of the resulting construct which is better than that obtained using standard machining techniques.

Comparative analysis of main bio-active components in the herb pair Danshen-Honghua and its single herbs by ultra-high performance liquid chromatography coupled to triple quadrupole tandem mass spectrometry.

PubMed

Qu, Cheng; Pu, Zong-Jin; Zhou, Gui-Sheng; Wang, Jun; Zhu, Zhen-Hua; Yue, Shi-Jun; Li, Jian-Ping; Shang, Li-Li; Tang, Yu-Ping; Shi, Xu-Qin; Liu, Pei; Guo, Jian-Ming; Sun, Jing; Tang, Zhi-Shu; Zhao, Jing; Zhao, Bu-Chang; Duan, Jin-Ao

2017-09-01

A sensitive, reliable, and powerful ultra-high performance liquid chromatography coupled to triple quadrupole tandem mass spectrometry method was developed for simultaneous quantification of the 15 main bio-active components including phenolic acids and flavonoids within 13 min for the first time. The proposed method was first reported and validated by good linearity (r 2  > 0.9975), limit of detection (1.12-7.01 ng/mL), limit of quantification (3.73-23.37 ng/mL), intra- and inter-day precisions (RSD ≤ 1.92%, RSD ≤ 2.45%), stability (RSD ≤ 5.63%), repeatability (RSD ≤ 4.34%), recovery (96.84-102.12%), and matrix effects (0.92-1.02). The established analytical methodology was successfully applied to comparative analysis of main bio-active components in the herb pair Danshen-Honghua and its single herbs. Compared to the single herb, the content of most flavonoid glycosides was remarkably increased in their herb pair, and main phenolic acids were decreased, conversely. The content changes of the main components in the herb pair supported the synergistic effects on promoting blood circulation and removing blood stasis. The results provide a scientific basis and reference for the quality control of Danshen-Honghua herb pair and the drug interactions based on variation of bio-active components in herb pairs. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Health impact of the 2008 cold spell on mortality in subtropical China: the climate and health impact national assessment study (CHINAs)

PubMed Central

2014-01-01

Background Many studies have investigated heat wave related mortality, but less attention has been given to the health effects of cold spells in the context of global warming. The 2008 cold spell in China provided a unique opportunity to estimate the effects of the 2008 cold spell on mortality in subtropical regions, spatial heterogeneity of the effects, stratification effect and added effects caused by sustained cold days. Methods Thirty-six study communities were selected from 15 provinces in subtropical China. Daily mortality and meteorological data were collected for each community from 2006 to 2010. A distributed lag linear non-linear model (DLNM) with a lag structure of up to 27 days was used to analyze the association between the 2008 cold spell and mortality. Multivariate meta-analyses were used to combine the cold effects across each community. Results The 2008 cold spell increased mortality by 43.8% (95% CI: 34.8% ~ 53.4%) compared to non-cold spell days with the highest effects in southern and central China. The effects were more pronounced for respiratory mortality (RESP) than for cardiovascular (CVD) or cerebrovascular mortality (CBD), for females more than for males, and for the elderly aged ≥75 years old more than for younger people. Overall, 148,279 excess deaths were attributable to the 2008 cold spell. The cold effect was mainly from extreme low temperatures rather than sustained cold days during this 2008 cold spell. Conclusions The 2008 cold spell increased mortality in subtropical China, which was mainly attributable to the low temperature rather than the sustained duration of the cold spell. The cold effects were spatially heterogeneous and modified by individual-specific characteristics such as gender and age. PMID:25060645

A Vibrating Wire System For Quadrupole Fiducialization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wolf, Zachary

2010-12-13

A vibrating wire system is being developed to fiducialize the quadrupoles between undulator segments in the LCLS. This note provides a detailed analysis of the system. The LCLS will have quadrupoles between the undulator segments to keep the electron beam focused. If the quadrupoles are not centered on the beam axis, the beam will receive transverse kicks, causing it to deviate from the undulator axis. Beam based alignment will be used to move the quadrupoles onto a straight line, but an initial, conventional alignment must place the quadrupole centers on a straight line to 100 {micro}m. In the fiducialization stepmore » of the initial alignment, the position of the center of the quadrupole is measured relative to tooling balls on the outside of the quadrupole. The alignment crews then use the tooling balls to place the magnet in the tunnel. The required error on the location of the quadrupole center relative to the tooling balls must be less than 25 {micro}m. In this note, we analyze a system under construction for the quadrupole fiducialization. The system uses the vibrating wire technique to position a wire onto the quadrupole magnetic axis. The wire position is then related to tooling balls using wire position detectors. The tooling balls on the wire position detectors are finally related to tooling balls on the quadrupole to perform the fiducialization. The total 25 {micro}m fiducialization error must be divided between these three steps. The wire must be positioned onto the quadrupole magnetic axis to within 10 {micro}m, the wire position must be measured relative to tooling balls on the wire position detectors to within 15 {micro}m, and tooling balls on the wire position detectors must be related to tooling balls on the quadrupole to within 10 {micro}m. The techniques used in these three steps will be discussed. The note begins by discussing various quadrupole fiducialization techniques used in the past and discusses why the vibrating wire technique is our method of choice. We then give an overview of the measurement system showing how the vibrating wire is positioned onto the quadrupole axis, how the wire position detectors locate the wire relative to tooling balls without touching the wire, and how the tooling ball positions are all measured. The novel feature of this system is the vibrating wire which we discuss in depth. We analyze the wire dynamics and calculate the expected sensitivity of the system. The note should be an aid in debugging the system by providing calculations to compare measurements to.« less

Supersonic Quadrupole Noise Theory for High-Speed Helicopter Rotors

NASA Technical Reports Server (NTRS)

Farassat, F.; Brentner, Kenneth S.

1997-01-01

High-speed helicopter rotor impulsive noise prediction is an important problem of aeroacoustics. The deterministic quadrupoles have been shown to contribute significantly to high-speed impulsive (HSI) noise of rotors, particularly when the phenomenon of delocalization occurs. At high rotor-tip speeds, some of the quadrupole sources lie outside the sonic circle and move at supersonic speed. Brentner has given a formulation suitable for efficient prediction of quadrupole noise inside the sonic circle. In this paper, we give a simple formulation based on the acoustic analogy that is valid for both subsonic and supersonic quadrupole noise prediction. Like the formulation of Brentner, the model is exact for an observer in the far field and in the rotor plane and is approximate elsewhere. We give the full analytic derivation of this formulation in the paper. We present the method of implementation on a computer for supersonic quadrupoles using marching cubes for constructing the influence surface (Sigma surface) of an observer space- time variable (x; t). We then present several examples of noise prediction for both subsonic and supersonic quadrupoles. It is shown that in the case of transonic flow over rotor blades, the inclusion of the supersonic quadrupoles improves the prediction of the acoustic pressure signature. We show the equivalence of the new formulation to that of Brentner for subsonic quadrupoles. It is shown that the regions of high quadrupole source strength are primarily produced by the shock surface and the flow over the leading edge of the rotor. The primary role of the supersonic quadrupoles is to increase the width of a strong acoustic signal.

The influence of quadrupole sources in the boundary layer and wake of a blade on helicopter rotor noise

NASA Technical Reports Server (NTRS)

Farassat, F.; Brentner, Kenneth S.

1991-01-01

It is presently noted that, for an observer in or near the plane containing a helicopter rotor disk, and in the far field, part of the volume quadrupole sources, and the blade and wake surface quadrupole sources, completely cancel out. This suggests a novel quadrupole source description for the Ffowcs Williams-Hawkings equation which retain quadrupoles with axes parallel to the rotor disk; in this case, the volume and shock surface sourse terms are dominant.

Conflicts of thermal adaptation and fever--a cybernetic approach based on physiological experiments.

PubMed

Werner, J; Beckmann, U

1998-01-01

Cold adaptation aims primarily at a better economy, i.e., preservation of energy often at the cost of a lower mean body temperature during cold stress, whereas heat adaptation whether achieved by exposure to a hot environment or by endogenous heat produced by muscle exercise, often brings about a higher efficiency of control, i.e., a lower mean body temperature during heat stress, at the cost of a higher water loss. While cold adaptation is beneficial in a cold environment, it may constitute a detrimental factor for exposure to a hot environment, mainly because of morphological adaptation. Heat adaptation may be maladaptive for cold exposure, mainly because of functional adaptation. Heat adaptation clearly is best suited to avoid higher body temperatures in fever, no matter which environmental conditions prevail. On the other hand, cold adaptation is detrimental for coping with fever in hot environment. Yet, in the cold, preceding cold adaptation may, because of reduced metabolic heat production, result in lower febrile increase of body temperature. Apparently controversial effects and results may be analyzed in the framework of a cybernetic approach to the main mechanisms of thermal adaptation and fever. Morphological adaptations alter the properties of the heat transfer characteristics of the body ("passive system"), whereas functional adaptation and fever concern the subsystems of control, namely sensors, integrative centers and effectors. In a closed control-loop the two types of adaptation have totally different consequences. It is shown that the experimental results are consistent with the predictions of such an approach.

Experimental and theoretical studies of dipole and quadrupole contributions to the vanadium K-edge XANES for VOPO4.2H2O xerogel

NASA Astrophysics Data System (ADS)

Poumellec, B.; Kraizman, V.; Aifa, Y.; Cortès, R.; Novakovich, A.; Vedrinskii, R.

1998-09-01

Angular dependence of the vanadium K-edge x-ray appearance near-edge structure (XANES) for the VOPO4.2H2O xerogel is thoroughly studied both experimentally and theoretically. The main attention is paid to the pre-edge fine structure (PEFS) of the spectra which was shown earlier to be a useful tool for the atomic short order investigations. Good quantitative agreement between theory and experiment obtained for both dipole and quadrupole contributions to the spectra proves validity of the calculation method developed and enables us to ascertain the nature of all the features in the PEFS's. The p-d mixture effect due to distortion of the central coordination octahedron and the quadrupole transitions are proved to be the only mechanisms responsible for the PEFS formation in the case considered. We show that in order to achieve quantitative agreement between experimental and theoretical spectra, it is necessary to include the effect of atomic vibrations, which makes the forbidden transitions to molecular orbitals of the central octahedron (MOCO's) dipole allowed, and to take into account deviation of the crystal layers from the substrate plane, which is not a single crystal but a texture.

Ab initio correlated calculations of rare-gas dimer quadrupoles

DOE Office of Scientific and Technical Information (OSTI.GOV)

Donchev, Alexander G.

2007-10-15

This paper reports ab initio calculations of rare gas (RG=Kr, Ar, Ne, and He) dimer quadrupoles at the second order of Moeller-Plesset perturbation theory (MP2). The study reveals the crucial role of the dispersion contribution to the RG{sub 2} quadrupole in the neighborhood of the equilibrium dimer separation. The magnitude of the dispersion quadrupole is found to be much larger than that predicted by the approximate model of Hunt. As a result, the total MP2 quadrupole moment is significantly smaller than was assumed in virtually all previous related studies. An analytical model for the distance dependence of the RG{sub 2}more » quadrupole is proposed. The model is based on the effective-electron approach of Jansen, but replaces the original Gaussian approximation to the electron density in an RG atom by an exponential one. The role of the nonadditive contribution in RG{sub 3} quadrupoles is discussed.« less

Investigation of the Effect of Rice Wine on the Metabolites of the Main Components of Herbal Medicine in Rat Urine by Ultrahigh-Performance Liquid Chromatography-Quadrupole/Time-of-Flight Mass Spectrometry: A Case Study on Cornus officinalis.

PubMed

Cao, Gang; Cai, Hao; Yue, Xianke; Tu, Sicong; Cai, Baochang; Xu, Zhiwei

2013-01-01

Ultrahigh-performance liquid chromatography-quadrupole/time-of-flight mass spectrometry (UPLC-QTOF/MS) was developed for rapid and sensitive analysis of the effect of rice wine on the metabolites of the main components of herbal medicine in rat urine. Using Cornus officinalis as a model of herbal medicine, the metabolite profiles of crude and processed (steaming the crude drug presteeped in rice wine) Cornus officinalis extracts in rat urine were investigated. The metabolites of Cornus officinalis were identified by using dynamic adjustment of the fragmentor voltage to produce structure-relevant fragment ions. In this work, we identified the parent compounds and metabolites of crude and processed Cornus officinalis in rats. In total, three parent compounds and seventeen new metabolites of Cornus officinalis were found in rats. The contents of the parent compounds and metabolites in vivo varied significantly after intragastric (i.g.) administration of aqueous extracts of crude and processed Cornus officinalis. Data from this study suggests that UPLC-QTOF/MS could be used as a potential tool for uncovering the effects of excipients found in the metabolites of the main components of herbal medicine, in vivo, to predict and discover the processing mechanisms of herbal medicine.

Comparison of conventional and novel quadrupole drift tube magnets inspired by Klaus Halbach

DOE Office of Scientific and Technical Information (OSTI.GOV)

Feinberg, B.

1995-02-01

Quadrupole drift tube magnets for a heavy-ion linac provide a demanding application of magnet technology. A comparison is made of three different solutions to the problem of providing an adjustable high-field-strength quadrupole magnet in a small volume. A conventional tape-wound electromagnet quadrupole magnet (conventional) is compared with an adjustable permanent-magnet/iron quadrupole magnet (hybrid) and a laced permanent-magnet/iron/electromagnet (laced). Data is presented from magnets constructed for the SuperHILAC heavy-ion linear accelerator, and conclusions are drawn for various applications.

The SLAC linac as used in the SLC collider

DOE Office of Scientific and Technical Information (OSTI.GOV)

Seeman, J.T.; Abrams, G.; Adolphsen, C.

The linac of the SLAC Linear Collider (SLC) must accelerate three high intensity bunches on each linac pulse from 1.2 GeV to 50 GeV with minimal increase of the small transverse emittance. The procedures and adjustments used to obtain this goal are outlined. Some of the accelerator parameters and components which interact are the beam energy, transverse position, component alignment, RF manipulation, feedback systems, quadrupole lattice, BNS damping, energy spectra, phase space matching, collimation, instrumentation and modelling. The method to bring these interdependent parameters collectively into specification has evolved over several years. This review is ordered in the sequence whichmore » is used to turn on the linac from a cold start and produce acceptable beams for the final focus and collisions. Approximate time estimates for the various activities are given. 21 refs.« less

Seeded hot dark matter models with inflation

NASA Technical Reports Server (NTRS)

Gratsias, John; Scherrer, Robert J.; Steigman, Gary; Villumsen, Jens V.

1993-01-01

We examine massive neutrino (hot dark matter) models for large-scale structure in which the density perturbations are produced by randomly distributed relic seeds and by inflation. Power spectra, streaming velocities, and the Sachs-Wolfe quadrupole fluctuation are derived for this model. We find that the pure seeded hot dark matter model without inflation produces Sachs-Wolfe fluctuations far smaller than those seen by COBE. With the addition of inflationary perturbations, fluctuations consistent with COBE can be produced. The COBE results set the normalization of the inflationary component, which determines the large-scale (about 50/h Mpc) streaming velocities. The normalization of the seed power spectrum is a free parameter, which can be adjusted to obtain the desired fluctuations on small scales. The power spectra produced are very similar to those seen in mixed hot and cold dark matter models.

Ground-state and pairing-vibrational bands with equal quadrupole collectivity in 124Xe

DOE Office of Scientific and Technical Information (OSTI.GOV)

Radich, A. J.; Garrett, P. E.; Allmond, J. M.

The nuclear structure of 124Xe has been investigated via measurements of the β +/EC decay of 124Cs with the 8π γ-ray spectrometer at the TRIUMF-ISAC facility. The data collected have enabled branching ratio measurements of weak, low-energy transitions from highly excited states, and the 2 + → 0 + in-band transitions have been observed. Combining these results with those from a previous Coulomb excitation study,more » $$B(E2; 2^+_3 → 0^+_2)$$ = 78(13) W.u. and $$B(E2; 2^+_4 → 0^+_3)$$ = 53(12) W.u. were determined. The $$0^+_3$$ state, in particular, is interpreted as the main fragment of the proton-pairing vibrational band identified in a previous 122Te( 3He,n) 124Xe measurement, and has quadrupole collectivity equal to, within uncertainty, that of the ground-state band.« less

Ground-state and pairing-vibrational bands with equal quadrupole collectivity in 124Xe

DOE PAGES

Radich, A. J.; Garrett, P. E.; Allmond, J. M.; ...

2015-04-01

The nuclear structure of 124Xe has been investigated via measurements of the β +/EC decay of 124Cs with the 8π γ-ray spectrometer at the TRIUMF-ISAC facility. The data collected have enabled branching ratio measurements of weak, low-energy transitions from highly excited states, and the 2 + → 0 + in-band transitions have been observed. Combining these results with those from a previous Coulomb excitation study,more » $$B(E2; 2^+_3 → 0^+_2)$$ = 78(13) W.u. and $$B(E2; 2^+_4 → 0^+_3)$$ = 53(12) W.u. were determined. The $$0^+_3$$ state, in particular, is interpreted as the main fragment of the proton-pairing vibrational band identified in a previous 122Te( 3He,n) 124Xe measurement, and has quadrupole collectivity equal to, within uncertainty, that of the ground-state band.« less

Design of high-energy high-current linac with focusing by superconducting solenoids

NASA Astrophysics Data System (ADS)

Batskikh, Guennady I.; Belugin, Vladimir M.; Bondarev, Boris I.; Fedotov, Arkady P.; Durkin, Alexander P.; Ivanov, Yury D.; Mikhailov, Vladimir N.; Murin, Boris P.; Mustafin, Kharis Kh.; Shumakov, Igor V.; Uksusov, Nikolay I.

1995-09-01

The advancement of MRTI design for 1.5 GeV and 250 mA ion CW linac is presented in the report. In new linac version all the way from input to output the ions are focused by magnetic fields of superconducting solenoids. The ion limit current is far beyond the needed value. The linac focusing channel offers major advantages over the more conventional ones. The acceptance is 1.7 times as large for such focusing channel as for quadrupole one. Concurrently, a random perturbation sensitivity for such channel is one order of magnitude smaller than in quadrupole channel. These focusing channel features allow to decrease beam matched radius and increase a linac radiation purity without aperture growth. ``Regotron'' is used as high power generator in linac main part. But D&W cavities need not be divided into sections connected by RF-bridges which denuded them of high coupling factor.

Is the Reaction of C3N(-) with C2H2 a Possible Process for Chain Elongation in Titan's Ionosphere?

PubMed

Lindén, Fredrik; Alcaraz, Christian; Ascenzi, Daniela; Guillemin, Jean-Claude; Koch, Leopold; Lopes, Allan; Polášek, Miroslav; Romanzin, Claire; Žabka, Jan; Zymak, Illia; Geppert, Wolf D

2016-07-14

The reaction of C3N(-) with acetylene was studied using three different experimental setups, a triple quadrupole mass spectrometer (Trento), a tandem quadrupole mass spectrometer (Prague), and the "CERISES" guided ion beam apparatus at Orsay. The process is of astrophysical interest because it can function as a chain elongation mechanism to produce larger anions that have been detected in Titan's ionosphere by the Cassini Plasma Spectrometer. Three major products of primary processes, C2H(-), CN(-), and C5N(-), have been identified, whereby the production of the cyanide anion is probably partly due to collisional induced dissociation. The formations of all these products show considerable reaction thresholds and also display comparatively small cross sections. Also, no strong signals of anionic products for collision energies lower than 1 eV have been observed. Ab initio calculations have been performed to identify possible pathways leading to the observed products of the title reaction and to elucidate the thermodynamics of these processes. Although the productions of CN(-) and C5N(-) are exoergic, all reaction pathways have considerable barriers. Overall, the results of these computations are in agreement with the observed reaction thresholds. Due to the existence of considerable reaction energy barriers and the small observed cross sections, the title reaction is not very likely to play a major role in the buildup of large anions in cold environments like the interstellar medium or planetary and satellite ionospheres.

Estimation of cold plasma outflow during geomagnetic storms

NASA Astrophysics Data System (ADS)

Haaland, S.; Eriksson, A.; André, M.; Maes, L.; Baddeley, L.; Barakat, A.; Chappell, R.; Eccles, V.; Johnsen, C.; Lybekk, B.; Li, K.; Pedersen, A.; Schunk, R.; Welling, D.

2015-12-01

Low-energy ions of ionospheric origin constitute a significant contributor to the magnetospheric plasma population. Measuring cold ions is difficult though. Observations have to be done at sufficiently high altitudes and typically in regions of space where spacecraft attain a positive charge due to solar illumination. Cold ions are therefore shielded from the satellite particle detectors. Furthermore, spacecraft can only cover key regions of ion outflow during segments of their orbit, so additional complications arise if continuous longtime observations, such as during a geomagnetic storm, are needed. In this paper we suggest a new approach, based on a combination of synoptic observations and a novel technique to estimate the flux and total outflow during the various phases of geomagnetic storms. Our results indicate large variations in both outflow rates and transport throughout the storm. Prior to the storm main phase, outflow rates are moderate, and the cold ions are mainly emanating from moderately sized polar cap regions. Throughout the main phase of the storm, outflow rates increase and the polar cap source regions expand. Furthermore, faster transport, resulting from enhanced convection, leads to a much larger supply of cold ions to the near-Earth region during geomagnetic storms.

Estimation of cold plasma outflow during geomagnetic storms

NASA Astrophysics Data System (ADS)

Haaland, S.; Eriksson, A. I.; Andre, M.; Maes, L.; Baddeley, L. J.; Barakat, A. R.; Chappell, C. R.; Eccles, V.; Johnsen, C.; Lybekk, B.; Li, K.; Pedersen, A.; Schunk, R. W.; Welling, D. T.

2015-12-01

Low energy ions of ionospheric origin provide a significant contributon to the magnetospheric plasmapopulation. Measuring cold ions is difficult though. Observations have to be done at sufficiently high altitudes and typically in regions of space where spacecraft attain a positive charge due to solar illumination. Cold ions are therefore shielded from the satellite particle detectors. Furthermore, spacecraft can only cover key regions of ion outflow during segments of their orbit, so additional complications arise arise if continuous longtime observations such as the during a geomagnetic storms are needed. In this paper we suggest a new approach, based on a combination of synoptic observations and a novel technique to estimate the flux and total outflow during the various phases of geomagnetic storms. Our results indicate large variations in both outflow rates and transport throughout the storm. Prior to the storm main phase, outflow rates are moderate, and the cold ions are mainly emanating from moderately sized polar cap regions. Throughout the main phase of the storm, outflow rates increase and the polar cap source regions expand. Furthermore, faster transport, resulting from enhanced convection, leads to a much larger supply of cold ions to the near Earth region during gemagnetic storms.

Quantitative Determination of Bioactive Constituents in Noni Juice by High-performance Liquid Chromatography with Electrospray Ionization Triple Quadrupole Mass Spectrometry.

PubMed

Yan, Yongqiu; Lu, Yu; Jiang, Shiping; Jiang, Yu; Tong, Yingpeng; Zuo, Limin; Yang, Jun; Gong, Feng; Zhang, Ling; Wang, Ping

2018-01-01

Noni juice has been extensively used as folk medicine for the treatment of arthritis, infections, analgesic, colds, cancers, and diabetes by Polynesians for many years. Due to the lack of standard scientific evaluation methods, various kinds of commercial Noni juice with different quality and price were available on the market. To establish a sensitive, reliable, and accurate high-performance liquid chromatography with electrospray ionization triple quadrupole mass spectrometry (HPLC-ESI-MS/MS) method for separation, identification, and simultaneous quantitative analysis of bioactive constituents in Noni juice. The analytes and eight batches of commercially available samples from different origins were separated and analyzed by the HPLC-ESI-MS/MS method on an Agilent ZORBAX SB-C 18 (150 mm × 4.6 mm i.d., 5 μm) column using a gradient elution of acetonitrile-methanol-0.05% glacial acetic acid in water (v/v) at a constant flow rate of 0.5 mL/min. Seven components were identification and all of the assay parameters were within the required limits. Components were within the correlation coefficient values ( R 2 ≥ 0.9993) at the concentration ranges tested. The precision of the assay method was <0.91% and the repeatability between 1.36% and 3.31%. The accuracy varied from 96.40% to 103.02% and the relative standard deviations of stability were <3.91%. Samples from the same origin showed similar content while different origins showed significant different result. The developed methods would provide a reliable basis and be useful in the establishment of a rational quality control standard of Noni juice. Separation, identification, and simultaneous quantitative analysis method of seven bioactive constituents in Noni juice is originally developed by high-performance liquid chromatography with electrospray ionization triple quadrupole mass spectrometryThe presented method was successfully applied to the quality control of eight batches of commercially available samples of Noni juiceThis method is simple, sensitive, reliable, accurate, and efficient method with strong specificity, good precision, and high recovery rate and provides a reliable basis for quality control of Noni juice. Abbreviations used: HPLC-ESI-MS/MS: High-performance liquid chromatography with electrospray ionization triple quadrupole mass spectrometry, LOD: Limit of detection, LOQ: Limit of quantitation, S/N: Signal-to-noise ratio, RSD: Relative standard deviations, DP: Declustering potential, CE: Collision energy, MRM: Multiple reaction monitoring, RT: Retention time.

Quantitative Determination of Bioactive Constituents in Noni Juice by High-performance Liquid Chromatography with Electrospray Ionization Triple Quadrupole Mass Spectrometry

PubMed Central

Yan, Yongqiu; Lu, Yu; Jiang, Shiping; Jiang, Yu; Tong, Yingpeng; Zuo, Limin; Yang, Jun; Gong, Feng; Zhang, Ling; Wang, Ping

2018-01-01

Background: Noni juice has been extensively used as folk medicine for the treatment of arthritis, infections, analgesic, colds, cancers, and diabetes by Polynesians for many years. Due to the lack of standard scientific evaluation methods, various kinds of commercial Noni juice with different quality and price were available on the market. Objective: To establish a sensitive, reliable, and accurate high-performance liquid chromatography with electrospray ionization triple quadrupole mass spectrometry (HPLC-ESI-MS/MS) method for separation, identification, and simultaneous quantitative analysis of bioactive constituents in Noni juice. Materials and Methods: The analytes and eight batches of commercially available samples from different origins were separated and analyzed by the HPLC-ESI-MS/MS method on an Agilent ZORBAX SB-C18 (150 mm × 4.6 mm i.d., 5 μm) column using a gradient elution of acetonitrile-methanol-0.05% glacial acetic acid in water (v/v) at a constant flow rate of 0.5 mL/min. Results: Seven components were identification and all of the assay parameters were within the required limits. Components were within the correlation coefficient values (R2 ≥ 0.9993) at the concentration ranges tested. The precision of the assay method was <0.91% and the repeatability between 1.36% and 3.31%. The accuracy varied from 96.40% to 103.02% and the relative standard deviations of stability were <3.91%. Samples from the same origin showed similar content while different origins showed significant different result. Conclusions: The developed methods would provide a reliable basis and be useful in the establishment of a rational quality control standard of Noni juice. SUMMARY Separation, identification, and simultaneous quantitative analysis method of seven bioactive constituents in Noni juice is originally developed by high-performance liquid chromatography with electrospray ionization triple quadrupole mass spectrometryThe presented method was successfully applied to the quality control of eight batches of commercially available samples of Noni juiceThis method is simple, sensitive, reliable, accurate, and efficient method with strong specificity, good precision, and high recovery rate and provides a reliable basis for quality control of Noni juice. Abbreviations used: HPLC-ESI-MS/MS: High-performance liquid chromatography with electrospray ionization triple quadrupole mass spectrometry, LOD: Limit of detection, LOQ: Limit of quantitation, S/N: Signal-to-noise ratio, RSD: Relative standard deviations, DP: Declustering potential, CE: Collision energy, MRM: Multiple reaction monitoring, RT: Retention time. PMID:29576704

Transcriptomic analysis of fruit stored under cold conditions using controlled atmosphere in Prunus persica cv. "Red Pearl".

PubMed

Sanhueza, Dayan; Vizoso, Paula; Balic, Iván; Campos-Vargas, Reinaldo; Meneses, Claudio

2015-01-01

Cold storage (CS) can induce a physiological disorder known as chilling injury (CI) in nectarine fruits. The main symptom is mealiness that is perceived as non-juicy fruit by consumers. Postharvest treatments such as controlled atmosphere (CA; a high CO2 concentration and low O2) have been used under cold conditions to avoid this disorder. With the objective of exploring the mechanisms involved in the CA effect on mealiness prevention, we analyzed transcriptomic changes under six conditions of "Red Pearl" nectarines by RNA-Seq. Our analysis included just harvested nectarines, juicy non-stored fruits, fruits affected for CI after CS and fruits stored in a combination of CA plus CS without CI phenotype. Nectarines stored in cold conditions combined with CA treatment resulted in less mealiness; we obtained 21.6% of juice content compared with just CS fruits (7.7%; mealy flesh). RNA-Seq data analyses were carried out to study the gene expression for different conditions assayed. During ripening, we detected that nectarines exposed to CA treatment expressed a similar number of genes compared with fruits that were not exposed to cold conditions. Firm fruits have more differentially expressed genes than soft fruits, which suggest that most important changes occur during CS. On the other hand, gene ontology analysis revealed enrichment mainly in metabolic and cellular processes. Differentially expressed genes analysis showed that low O2 concentrations combined with cold conditions slows the metabolic processes more than just the cold storage, resulting mainly in the suppression of primary metabolism and cold stress response. This is a significant step toward unraveling the molecular mechanism that explains the effectiveness of CA as a tool to prevent CI development on fruits.

Transcriptomic analysis of fruit stored under cold conditions using controlled atmosphere in Prunus persica cv. “Red Pearl”

PubMed Central

Sanhueza, Dayan; Vizoso, Paula; Balic, Iván; Campos-Vargas, Reinaldo; Meneses, Claudio

2015-01-01

Cold storage (CS) can induce a physiological disorder known as chilling injury (CI) in nectarine fruits. The main symptom is mealiness that is perceived as non-juicy fruit by consumers. Postharvest treatments such as controlled atmosphere (CA; a high CO2 concentration and low O2) have been used under cold conditions to avoid this disorder. With the objective of exploring the mechanisms involved in the CA effect on mealiness prevention, we analyzed transcriptomic changes under six conditions of “Red Pearl” nectarines by RNA-Seq. Our analysis included just harvested nectarines, juicy non-stored fruits, fruits affected for CI after CS and fruits stored in a combination of CA plus CS without CI phenotype. Nectarines stored in cold conditions combined with CA treatment resulted in less mealiness; we obtained 21.6% of juice content compared with just CS fruits (7.7%; mealy flesh). RNA-Seq data analyses were carried out to study the gene expression for different conditions assayed. During ripening, we detected that nectarines exposed to CA treatment expressed a similar number of genes compared with fruits that were not exposed to cold conditions. Firm fruits have more differentially expressed genes than soft fruits, which suggest that most important changes occur during CS. On the other hand, gene ontology analysis revealed enrichment mainly in metabolic and cellular processes. Differentially expressed genes analysis showed that low O2 concentrations combined with cold conditions slows the metabolic processes more than just the cold storage, resulting mainly in the suppression of primary metabolism and cold stress response. This is a significant step toward unraveling the molecular mechanism that explains the effectiveness of CA as a tool to prevent CI development on fruits. PMID:26483806

Evaporative cooling of the dipolar hydroxyl radical.

PubMed

Stuhl, Benjamin K; Hummon, Matthew T; Yeo, Mark; Quéméner, Goulven; Bohn, John L; Ye, Jun

2012-12-20

Atomic physics was revolutionized by the development of forced evaporative cooling, which led directly to the observation of Bose-Einstein condensation, quantum-degenerate Fermi gases and ultracold optical lattice simulations of condensed-matter phenomena. More recently, substantial progress has been made in the production of cold molecular gases. Their permanent electric dipole moment is expected to generate systems with varied and controllable phases, dynamics and chemistry. However, although advances have been made in both direct cooling and cold-association techniques, evaporative cooling has not been achieved so far. This is due to unfavourable ratios of elastic to inelastic scattering and impractically slow thermalization rates in the available trapped species. Here we report the observation of microwave-forced evaporative cooling of neutral hydroxyl (OH(•)) molecules loaded from a Stark-decelerated beam into an extremely high-gradient magnetic quadrupole trap. We demonstrate cooling by at least one order of magnitude in temperature, and a corresponding increase in phase-space density by three orders of magnitude, limited only by the low-temperature sensitivity of our spectroscopic thermometry technique. With evaporative cooling and a sufficiently large initial population, much colder temperatures are possible; even a quantum-degenerate gas of this dipolar radical (or anything else it can sympathetically cool) may be within reach.

Rotational Quenching Study in Isovalent H+ + CO and H+ + CS Systems

NASA Astrophysics Data System (ADS)

Kaur, Rajwant; Dhilip Kumar, T. J.

2016-06-01

Cooling and trapping of polar molecules has attracted attention at cold and ultracold temperatures. Extended study of molecular inelastic collision processes of polar interstellar species with proton finds an important astrophysical application to model interstellar medium. Present study includes computation of rate coefficient for molecular rotational quenching process in proton collision with isovalent CO and CS molecules using quantum dynamical close-coupling calculations. Full dimensional ab initio potential energy surfaces have been computed for the ground state for both the systems using internally contracted multireference configuration interaction method and basis sets. Quantum scattering calculations for rotational quenching of isovalent species are studied in the rigid-rotor approximation with CX (X=O, S) bond length fixed at an experimental equilibrium value of 2.138 and 2.900 a.u., respectively. Asymptotic potentials are computed using the dipole and quadrupole moments, and the dipole polarizability components. The resulting long-range potentials with the short-range ab initio interaction potentials have been fitted to study the anisotropy of the rigid-rotor surface using the multipolar expansion coefficients. Rotational quenching cross-section and corresponding rates from j=4 level of CX to lower j' levels have been obtained and found to obey Wigner's threshold law at ultra cold temperatures.

Miniature micromachined quadrupole mass spectrometer array and method of making the same

NASA Technical Reports Server (NTRS)

Chutjian, Ara (Inventor); Brennen, Reid A. (Inventor); Hecht, Michael (Inventor); Wiberg, Dean (Inventor); Orient, Otto (Inventor)

2001-01-01

The present invention provides a quadrupole mass spectrometer and an ion filter for use in the quadrupole mass spectrometer. The ion filter includes a thin patterned layer including a two-dimensional array of poles forming one or more quadrupoles. The patterned layer design permits the use of very short poles and with a very dense spacing of the poles, so that the ion filter may be made very small. Also provided is a method for making the ion filter and the quadrupole mass spectrometer. The method involves forming the patterned layer of the ion filter in such a way that as the poles of the patterned layer are formed, they have the relative positioning and alignment for use in a final quadrupole mass spectrometer device.

Miniature micromachined quadrupole mass spectrometer array and method of making the same

NASA Technical Reports Server (NTRS)

Fuerstenau, Stephen D. (Inventor); Yee, Karl Y. (Inventor); Chutjian, Ara (Inventor); Orient, Otto J. (Inventor); Rice, John T. (Inventor)

2002-01-01

The present invention provides a quadrupole mass spectrometer and an ion filter, or pole array, for use in the quadrupole mass spectrometer. The ion filter includes a thin patterned layer including a two-dimensional array of poles forming one or more quadrupoles. The patterned layer design permits the use of very short poles and with a very dense spacing of the poles, so that the ion filter may be made very small. Also provided is a method for making the ion filter and the quadrupole mass spectrometer. The method involves forming the patterned layer of the ion filter in such a way that as the poles of the patterned layer are formed, they have the relative positioning and alignment for use in a final quadrupole mass spectrometer device.

Miniature micromachined quadrupole mass spectrometer array and method of making the same

NASA Technical Reports Server (NTRS)

Chutjian, Ara (Inventor); Rice, John T. (Inventor); Fuerstenau, Stephen D. (Inventor); Orient, Otto J. (Inventor); Yee, Karl Y. (Inventor)

2000-01-01

The present invention provides a quadrupole mass spectrometer and an ion filter, or pole array, for use in the quadrupole mass spectrometer. The ion filter includes a thin patterned layer including a two-dimensional array of poles forming one or more quadrupoles. The patterned layer design permits the use of very short poles and with a very dense spacing of the poles, so that the ion filter may be made very small. Also provided is a method for making the ion filter and the quadrupole mass spectrometer. The method involves forming the patterned layer of the ion filter in such a way that as the poles of the patterned layer are formed, they have the relative positioning and alignment for use in a final quadrupole mass spectrometer device.

Miniature micromachined quadrupole mass spectrometer array and method of making the same

NASA Technical Reports Server (NTRS)

Yee, Karl Y. (Inventor); Fuerstenau, Stephen D. (Inventor); Orient, Otto J. (Inventor); Rice, John T. (Inventor); Chutjian, Ara (Inventor)

2001-01-01

The present invention provides a quadrupole mass spectrometer and an ion filter, or pole array, for use in the quadrupole mass spectrometer. The ion filter includes a thin patterned layer including a two-dimensional array of poles forming one or more quadrupoles. The patterned layer design permits the use of very short poles and with a very dense spacing of the poles, so that the ion filter may be made very small. Also provided is a method for making the ion filter and the quadrupole mass spectrometer. The method involves forming the patterned layer of the ion filter in such a way that as the poles of the patterned layer are formed, they have the relative positioning and alignment for use in a final quadrupole mass spectrometer device.

Miniature micromachined quadrupole mass spectrometer array and method of making the same

NASA Technical Reports Server (NTRS)

Hecht, Michael (Inventor); Wiberg, Dean (Inventor); Orient, Otto (Inventor); Brennen, Reid A. (Inventor); Chutjian, Ara (Inventor)

2001-01-01

The present invention provides a quadrupole mass spectrometer and an ion filter for use in the quadrupole mass spectrometer. The ion filter includes a thin patterned layer including a two-dimensional array of poles forming one or more quadrupoles. The patterned layer design permits the use of very short poles and with a very dense spacing of the poles, so that the ion filter may be made very small. Also provided is a method for making the ion filter and the quadrupole mass spectrometer. The method involves forming the patterned layer of the ion filter in such a way that as the poles of the patterned layer are formed, they have the relative positioning and aligrnent for use in a final quadrupole mass spectrometer device.

Miniature micromachined quadrupole mass spectrometer array and method of making the same

NASA Technical Reports Server (NTRS)

Orient, Otto (Inventor); Wiberg, Dean (Inventor); Brennen, Reid A. (Inventor); Hecht, Michael (Inventor); Chutjian, Ara (Inventor)

2000-01-01

The present invention provides a quadrupole mass spectrometer and an ion filter for use in the quadrupole mass spectrometer. The ion filter includes a thin patterned layer including a two-dimensional array of poles forming one or more quadrupoles. The patterned layer design permits the use of very short poles and with a very dense spacing of the poles, so that the ion filter may be made very small. Also provided is a method for making the ion filter and the quadrupole mass spectrometer. The method involves forming the patterned layer of the ion filter in such a way that as the poles of the patterned layer are formed, they have the relative positioning and alignment for use in a final quadrupole mass spectrometer device.

Nuclear quadrupole resonance studies in semi-metallic structures

NASA Technical Reports Server (NTRS)

Murty, A. N.

1974-01-01

Both experimental and theoretical studies are presented on spectrum analysis of nuclear quadrupole resonance of antimony and arsenic tellurides. Numerical solutions for secular equations of the quadrupole interaction energy are also discussed.

Nuclear Quadrupole Moments and Nuclear Shell Structure

DOE R&D Accomplishments Database

Townes, C. H.; Foley, H. M.; Low, W.

1950-06-23

Describes a simple model, based on nuclear shell considerations, which leads to the proper behavior of known nuclear quadrupole moments, although predictions of the magnitudes of some quadrupole moments are seriously in error.

Hot and Cold Drugs: National Park Service Medication Stability at the Extremes of Temperature.

PubMed

Armenian, Patil; Campagne, Danielle; Stroh, Geoff; Ives Tallman, Crystal; Zeng, William Z D; Lin, Thomas; Gerona, Roy R

2017-01-01

National Park Service (NPS) Parkmedics provide medical care in austere environments. The objective of this study was to evaluate the stability of specific medications used by Parkmedics at extremes of temperatures likely to be faced in the field. This is a bench research study conducted in the laboratory setting over a 4-week period. Parenteral medications were separated into 4 temperature exposure groups: A) 45°C (hot); B) -20°C (cold); C) hot then cold temperatures alternating weekly; and D) cold then hot temperatures alternating weekly. At study start and the end of each week, three aliquots from each group were sampled to determine the remaining drug concentration through liquid chromatography-quadrupole time-of-flight mass spectrometry (Agilent LC 1260- QTOF/MS 6550). Quantitative analysis was done using Agilent MassHunter Quantitative Analysis software. The mean drug concentration from triplicate aliquots was expressed as percentage of its baseline concentration to monitor the drug's stability during storage. Eight medications were analyzed (atropine, diphenhydramine, fentanyl, hydromorphone, midazolam, morphine, naloxone, ondansetron). Hydromorphone, morphine, and ondansetron showed the greatest stability, at above 90% of original concentration in all study arms. Diphenhydramine, fentanyl and midazolam showed heat independent degradation, degrading the same way regardless of heat exposure. By the end of the study period, 51-56% midazolam remained in all groups. Atropine and naloxone showed heat dependent degradation, degrading more when exposed to heat. Atropine had the most degradation, being undetectable after 4 weeks of heat exposure. We recommend that EMS providers replace atropine, naloxone, diphenhydramine, fentanyl, and midazolam frequently if they are practicing in low call volume or high-temperature environments. Further studies will be needed to determine if re-dosing midazolam, naloxone, and atropine is the appropriate clinical strategy in this setting if adequate clinical effect is not reached with a single dose.

Means and method for the focusing and acceleration of parallel beams of charged particles

DOEpatents

Maschke, Alfred W.

1983-07-05

A novel apparatus and method for focussing beams of charged particles comprising planar arrays of electrostatic quadrupoles. The quadrupole arrays may comprise electrodes which are shared by two or more quadrupoles. Such quadrupole arrays are particularly adapted to providing strong focussing forces for high current, high brightness, beams of charged particles, said beams further comprising a plurality of parallel beams, or beamlets, each such beamlet being focussed by one quadrupole of the array. Such arrays may be incorporated in various devices wherein beams of charged particles are accelerated or transported, such as linear accelerators, klystron tubes, beam transport lines, etc.

Noise reduction in negative-ion quadrupole mass spectrometry

DOEpatents

Chastagner, P.

1993-04-20

A quadrupole mass spectrometer (QMS) system is described having an ion source, quadrupole mass filter, and ion collector/recorder system. A weak, transverse magnetic field and an electron collector are disposed between the quadrupole and ion collector. When operated in negative ion mode, the ion source produces a beam of primarily negatively-charged particles from a sample, including electrons as well as ions. The beam passes through the quadrupole and enters the magnetic field, where the electrons are deflected away from the beam path to the electron collector. The negative ions pass undeflected to the ion collector where they are detected and recorded as a mass spectrum.

Noise reduction in negative-ion quadrupole mass spectrometry

DOEpatents

Chastagner, Philippe

1993-01-01

A quadrupole mass spectrometer (QMS) system having an ion source, quadrupole mass filter, and ion collector/recorder system. A weak, transverse magnetic field and an electron collector are disposed between the quadrupole and ion collector. When operated in negative ion mode, the ion source produces a beam of primarily negatively-charged particles from a sample, including electrons as well as ions. The beam passes through the quadrupole and enters the magnetic field, where the electrons are deflected away from the beam path to the electron collector. The negative ions pass undeflected to the ion collector where they are detected and recorded as a mass spectrum.

LMFBR with booster pump in pumping loop

DOEpatents

Rubinstein, H.J.

1975-10-14

A loop coolant circulation system is described for a liquid metal fast breeder reactor (LMFBR) utilizing a low head, high specific speed booster pump in the hot leg of the coolant loop with the main pump located in the cold leg of the loop, thereby providing the advantages of operating the main pump in the hot leg with the reliability of cold leg pump operation.

Particle beam injector system and method

DOEpatents

Guethlein, Gary

2013-06-18

Methods and devices enable coupling of a charged particle beam to a radio frequency quadrupole accelerator. Coupling of the charged particle beam is accomplished, at least in-part, by relying on of sensitivity of the input phase space acceptance of the radio frequency quadrupole to the angle of the input charged particle beam. A first electric field across a beam deflector deflects the particle beam at an angle that is beyond the acceptance angle of the radio frequency quadrupole. By momentarily reversing or reducing the established electric field, a narrow portion of the charged particle beam is deflected at an angle within the acceptance angle of the radio frequency quadrupole. In another configuration, beam is directed at an angle within the acceptance angle of the radio frequency quadrupole by the first electric field and is deflected beyond the acceptance angle of the radio frequency quadrupole due to the second electric field.

Simultaneous Analysis of Iridoid Glycosides and Anthraquinones in Morinda officinalis Using UPLC-QqQ-MS/MS and UPLC-Q/TOF-MSE.

PubMed

Zhao, Xiangsheng; Wei, Jianhe; Yang, Meihua

2018-05-03

Morinda officinalis is an important herbal medicine and functional food, and its main constituents include anthraquinone and iridoid glycosides. Quantification of the main compounds is a necessary step to understand the quality and therapeutic properties of M. officinalis , but this has not yet been performed based on liquid chromatography/tandem mass spectrometry (LC-MS/MS). Analytes were extracted from M. officinalis by reflux method. Ultrahigh-performance liquid chromatography coupled with a triple quadrupole mass spectrometry (UPLC-QqQ-MS) using multiple reaction monitoring (MRM) mode was applied for quantification. Fragmentation pathways of deacetyl asperulosidic acid and rubiadin were investigated based on UPLC with quadrupole time-of-flight tandem mass spectrometry (Q/TOF-MS) in the MS E centroid mode. The method showed a good linearity over a wide concentration range (R² ≥ 0.9930). The limits of quantification of six compounds ranged from 2.6 to 27.57 ng/mL. The intra- and inter-day precisions of the investigated components exhibited an RSD within 4.5% with mean recovery rates of 95.32⁻99.86%. Contents of selected compounds in M. officinalis varied significantly depending on region. The fragmentation pathway of deacetyl asperulosidic and rubiadin was proposed. A selective and sensitive method was developed for determining six target compounds in M. officinalis by UPLC-MS/MS. Furthermore, the proposed method will be helpful for quality control and identification main compounds of M. officinalis .

Cold Fronts in RegCM/HadGEM simulations over South America

NASA Astrophysics Data System (ADS)

Pampuch, Luana; Marcos de Jesus, Eduardo; Porfírio da Rocha, Rosmeri; Ambrizzi, Tércio

2017-04-01

Cold front is one of the most important systems that contribute for precipitation over South America. The representation of this system in climate models is important for a better representation of the precipitation. The Regional Climate Model RegCM is widely used for climate studies in South America, being important to understand how this model represents the cold fronts. A climatology (from 1979-2004) of the number of cold fronts in each season for RegCM4 simulations over South America CORDEX domain nested in HadGEM2-ES. The simulated climatology was compared with ERA-Interim reanalysis cold fronts climatology over the South America and adjacent South Atlantic Ocean. The cold fronts tracking for the model and the reanalysis were performed using an objective methodology based on decrease of air temperature in 925hPa, shift of meridional wind in 925hPa from northern to southern quadrant and increased in sea level pressure. The main differences were observed on summer and winter. On summer the model overestimate the number of cold fronts over southeastern South America and adjacent Atlantic Ocean; and underestimate it over central-south Argentina and Atlantic Ocean. On winter, the signs were opposite of that summer. On autumn and spring the differences were smaller and occurs mainly over all South Atlantic and north Argentina.

Synthetic Landau Levels and Spinor Vortex Matter on a Haldane Spherical Surface with a Magnetic Monopole.

PubMed

Zhou, Xiang-Fa; Wu, Congjun; Guo, Guang-Can; Wang, Ruquan; Pu, Han; Zhou, Zheng-Wei

2018-03-30

We present a flexible scheme to realize exact flat Landau levels on curved spherical geometry in a system of spinful cold atoms. This is achieved by applying the Floquet engineering of a magnetic quadrupole field to create a synthetic monopole field in real space. The system can be exactly mapped to the electron-monopole system on a sphere, thus realizing Haldane's spherical geometry for fractional quantum Hall physics. This method works for either bosons or fermions. We investigate the ground-state vortex pattern for an s-wave interacting atomic condensate by mapping this system to the classical Thompson's problem. The distortion and stability of the vortex pattern are further studied in the presence of dipolar interaction. Our scheme is compatible with the current experimental setup, and may serve as a promising route of investigating quantum Hall physics and exotic spinor vortex matter on curved space.

Synthetic Landau Levels and Spinor Vortex Matter on a Haldane Spherical Surface with a Magnetic Monopole

NASA Astrophysics Data System (ADS)

Zhou, Xiang-Fa; Wu, Congjun; Guo, Guang-Can; Wang, Ruquan; Pu, Han; Zhou, Zheng-Wei

2018-03-01

We present a flexible scheme to realize exact flat Landau levels on curved spherical geometry in a system of spinful cold atoms. This is achieved by applying the Floquet engineering of a magnetic quadrupole field to create a synthetic monopole field in real space. The system can be exactly mapped to the electron-monopole system on a sphere, thus realizing Haldane's spherical geometry for fractional quantum Hall physics. This method works for either bosons or fermions. We investigate the ground-state vortex pattern for an s -wave interacting atomic condensate by mapping this system to the classical Thompson's problem. The distortion and stability of the vortex pattern are further studied in the presence of dipolar interaction. Our scheme is compatible with the current experimental setup, and may serve as a promising route of investigating quantum Hall physics and exotic spinor vortex matter on curved space.

Klystron having electrostatic quadrupole focusing arrangement

DOEpatents

Maschke, Alfred W.

1983-08-30

A klystron includes a source for emitting at least one electron beam, and an accelerator for accelarating the beam in a given direction through a number of drift tube sections successively aligned relative to one another in the direction of the beam. A number of electrostatic quadrupole arrays are successively aligned relative to one another along at least one of the drift tube sections in the beam direction for focusing the electron beam. Each of the electrostatic quadrupole arrays forms a different quadrupole for each electron beam. Two or more electron beams can be maintained in parallel relationship by the quadrupole arrays, thereby enabling space charge limitations encountered with conventional single beam klystrons to be overcome.

Klystron having electrostatic quadrupole focusing arrangement

DOEpatents

Maschke, A.W.

1983-08-30

A klystron includes a source for emitting at least one electron beam, and an accelerator for accelerating the beam in a given direction through a number of drift tube sections successively aligned relative to one another in the direction of the beam. A number of electrostatic quadrupole arrays are successively aligned relative to one another along at least one of the drift tube sections in the beam direction for focusing the electron beam. Each of the electrostatic quadrupole arrays forms a different quadrupole for each electron beam. Two or more electron beams can be maintained in parallel relationship by the quadrupole arrays, thereby enabling space charge limitations encountered with conventional single beam klystrons to be overcome. 4 figs.

A modified quadrupole mass spectrometer with custom RF link rods driver for remote operation

NASA Technical Reports Server (NTRS)

Tashbar, P. W.; Nisen, D. B.; Moore, W. W., Jr.

1973-01-01

A commercial quadrupole residual gas analyzer system has been upgraded for operation at extended cable lengths. Operation inside a vacuum chamber for the standard quadrupole nude head is limited to approximately 2 m from its externally located rf/dc generator because of the detuning of the rf oscillator circuits by the coaxial cable reactance. The advance of long distance remote operation inside a vacuum chamber for distances of 45 and 60 m was made possible without altering the quadrupole's rf/dc generator circuit by employing an rf link to drive the quadrupole rods. Applications of the system have been accomplished for in situ space simulation thermal/vacuum testing of sophisticated payloads.

Microscopically derived potential energy surfaces from mostly structural considerations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ermamatov, M.J.; Institute of Nuclear Physics, Ulughbek, Tashkent 100214; Hess, Peter O., E-mail: hess@nucleares.unam.mx

2016-08-15

A simple procedure to estimate the quadrupole Potential-Energy-Surface (PES) is presented, using mainly structural information, namely the content of the shell model space and the Pauli exclusion principle. Further microscopic properties are implicitly contained through the use of results from the Möller and Nix tables or experimental information. A mapping to the geometric potential is performed yielding the PES. The General Collective Model is used in order to obtain an estimate on the spectrum and quadrupole transitions, adjusting only the mass parameter. First, we test the conjecture on known nuclei, deriving the PES and compare them to known data. Wemore » will see that the PES approximates very well the structure expected. Having acquired a certain confidence, we predict the PES of several chain of isotopes of heavy and super-heavy nuclei and at the end we investigate the structure of nuclei in the supposed island of stability. One of the main points to show is that simple assumptions can provide already important information on the structure of nuclei outside known regions and that spectra and electromagnetic transitions can be estimated without using involved calculations and assumptions. The procedure does not allow to calculate binding energies. The method presented can be viewed as a starting point for further improvements.« less

SNS Resonance Control Cooling Systems and Quadrupole Magnet Cooling Systems DIW Chemistry

DOE Office of Scientific and Technical Information (OSTI.GOV)

Magda, Karoly

This report focuses on control of the water chemistry for the Spallation Neutron Source (SNS) Resonance Control Cooling System (RCCS)/Quadrupole Magnet Cooling System (QMCS) deionized water (DIW) cooling loops. Data collected from spring 2013 through spring 2016 are discussed, and an operations regime is recommended.It was found that the RCCS operates with an average pH of 7.24 for all lines (from 7.0 to 7.5, slightly alkaline), the average low dissolved oxygen is in the area of < 36 ppb, and the main loop average resistivity of is > 14 MΩ-cm. The QMCS was found to be operating in a similarmore » regime, with a slightly alkaline pH of 7.5 , low dissolved oxygen in the area of < 45 ppb, and main loop resistivity of 10 to 15 MΩ-cm. During data reading, operational corrections were done on the polishing loops to improve the water chemistry regime. Therefore some trends changed over time.It is recommended that the cooling loops operate in a regime in which the water has a resistivity that is as high as achievable, a dissolved oxygen concentration that is as low as achievable, and a neutral or slightly alkaline pH.« less

Bashful ballerina unveiled: Multipole analysis of the coronal magnetic field

NASA Astrophysics Data System (ADS)

Virtanen, I.; Mursula, K.

2012-12-01

Heliospheric current sheet (HCS) is the continuum of the coronal magnetic equator, dividing the heliospheric magnetic field (HMF) into two sectors (polarities). Because of its wavy structure, the HCS is often called the ballerina skirt. Several studies have proven that the HCS is southward shifted during about three years in the solar declining phase. This persistent phenomenon, called the bashful ballerina, has been verified by geomagnetic indices since 1930s, by OMNI data base since 1960s, by the WSO PFSS model since mid-1970s and by the Ulysses probe measurements during the fast latitude scans in 1994-1995 and 2007. We study here the Wilcox Solar Observatory measurements of the photospheric magnetic field and the PFSS extrapolation of the coronal magnetic field. We show that the quadrupole moment of the photospheric magnetic field, which is important for the HCS asymmetry (bashful ballerina), mainly arises from the difference between northern and southern polar field strengths. According to the WSO data the minimum time quadrupole is mainly due to the difference between the highest northern and southern latitude bins. Related studies imply that the southward shift of the HCS is related to the delayed development of southern coronal holes. We also discuss the suggested connection of the HCS asymmetry to sunspot hemispheric asymmetry.

Analysis of the impact of modification of cold crucible design on the efficiency of the cold crucible induction furnace

NASA Astrophysics Data System (ADS)

Przylucki, R.; Golak, S.; Bulinski, P.; Smolka, J.; Palacz, M.; Siwiec, G.; Lipart, J.; Blacha, L.

2018-05-01

The article includes numerical simulation results for two induction furnace with cold crucible (IFCC). Induction furnaces differ in cold crucible design, while the inductor geometry was preserved for both variants. Numerical simulations were conducted as three dimensional one, with coupled analysis of electromagnetic, thermal and fluid dynamics fields. During the experiment, six calculation variants, differ in amount of molten titanium (three different weights of titanium for each type of cold crucible) were considered. Main parameters controlled during the calculations were: electrical efficiency of the IFCC and the meniscus shape of liquid metal.

Who Won the Cold War? A Learning Packet for Secondary Level Study.

ERIC Educational Resources Information Center

Kansas Univ., Lawrence. Center for Russian and East European Studies.

Realizing that the Cold War is a topic that often is neglected as time runs short at the end of a school year, a group of University of Kansas (Lawrence) educators sought to create effective classroom materials for secondary/community college instructors to teach about the Cold War. The group's main goal was to create a flexible model that…

The Profiling and Identification of the Absorbed Constituents and Metabolites of Guizhi Decoction in Rat Plasma and Urine by Rapid Resolution Liquid Chromatography Combined with Quadrupole-Time-of-Flight Mass Spectrometry.

PubMed

Xiang, Hongjun; Zhang, Lishi; Song, Jiannan; Fan, Bin; Nie, Yinglan; Bai, Dong; Lei, Haimin

2016-09-12

Guizhi decoction (GZD), a well-known traditional Chinese medicine (TCM) prescription consisting of Ramulus Cinnamomi, Radix Paeoniae Alba, Radix Glycyrrhizae, Fructus Jujubae and Rhizoma Zingiberis Recens, is usually used for the treatment of common colds, influenza, and other pyretic conditions in the clinic. However, the absorbed ingredients and metabolic compounds of GZD have not been reported. In this paper, a method incorporating rapid resolution liquid chromatography (RRLC) with quadrupole-time-of-flight mass spectrometry (Q-TOF-MS) was used to identify ingredients after oral administration of GZD. Identification of the primary components in GZD, drug-containing serum and urine samples was carried out in order to investigate the assimilation and metabolites of the decoction in vivo. By comparing the total ion chromatograms (TICs) of GZD, a total of 71 constituents were detected or characterized. By comparing TICs of blank and dosed rat plasma, a total of 15 constituents were detected and identified as prototypes according to their retention time (tR) and MS, MS/MS data. Based on this, neutral loss scans of 80 and 176 Da in samples of rat plasma and urine helped us to identify most of the metabolites. Results showed that the predominant metabolic pathways of (epi) catechin and gallic acid were sulfation, methylation, glucuronidation and dehydroxylation; the major metabolic pathways of flavone were hydrolysis, sulfation and glucuronidation. Furthermore, degradation, oxidation and ring fission were found to often occur in the metabolism process of GZD in vivo.

The Profiling and Identification of the Absorbed Constituents and Metabolites of Guizhi Decoction in Rat Plasma and Urine by Rapid Resolution Liquid Chromatography Combined with Quadrupole-Time-of-Flight Mass Spectrometry

PubMed Central

Xiang, Hongjun; Zhang, Lishi; Song, Jiannan; Fan, Bin; Nie, Yinglan; Bai, Dong; Lei, Haimin

2016-01-01

Guizhi decoction (GZD), a well-known traditional Chinese medicine (TCM) prescription consisting of Ramulus Cinnamomi, Radix Paeoniae Alba, Radix Glycyrrhizae, Fructus Jujubae and Rhizoma Zingiberis Recens, is usually used for the treatment of common colds, influenza, and other pyretic conditions in the clinic. However, the absorbed ingredients and metabolic compounds of GZD have not been reported. In this paper, a method incorporating rapid resolution liquid chromatography (RRLC) with quadrupole-time-of-flight mass spectrometry (Q-TOF-MS) was used to identify ingredients after oral administration of GZD. Identification of the primary components in GZD, drug-containing serum and urine samples was carried out in order to investigate the assimilation and metabolites of the decoction in vivo. By comparing the total ion chromatograms (TICs) of GZD, a total of 71 constituents were detected or characterized. By comparing TICs of blank and dosed rat plasma, a total of 15 constituents were detected and identified as prototypes according to their retention time (tR) and MS, MS/MS data. Based on this, neutral loss scans of 80 and 176 Da in samples of rat plasma and urine helped us to identify most of the metabolites. Results showed that the predominant metabolic pathways of (epi) catechin and gallic acid were sulfation, methylation, glucuronidation and dehydroxylation; the major metabolic pathways of flavone were hydrolysis, sulfation and glucuronidation. Furthermore, degradation, oxidation and ring fission were found to often occur in the metabolism process of GZD in vivo. PMID:27626411

Multipolar Kondo effect in a S10-P32 mixture of 173Yb atoms

NASA Astrophysics Data System (ADS)

Kuzmenko, Igor; Kuzmenko, Tetyana; Avishai, Yshai; Jo, Gyu-Boong

2018-02-01

Whereas in the familiar Kondo effect the exchange interaction is dipolar, there are systems in which the exchange interaction is multipolar, as has been realized in a recent experiment. Here, we study multipolar Kondo effect in a Fermi gas of cold 173Yb atoms. Making use of different ac polarizabilities of the electronic ground state Yb (S10 ) and the long-lived metastable state Yb*(P32 ), it is suggested that the latter atoms can be localized and serve as a dilute concentration of magnetic impurities while the former ones remain itinerant. The exchange mechanism between the itinerant Yb and the localized Yb* atoms is analyzed and shown to be antiferromagnetic. The quadrupole and octupole interactions act to enhance the Kondo temperature TK that is found to be experimentally accessible. The bare exchange Hamiltonian needs to be decomposed into dipole (d), quadrupole (q), and octupole (o) interactions in order to retain its form under renormalization group (RG) analysis, in which the corresponding exchange constants (λd,λq, and λo) flow independently. Numerical solution of the RG scaling equations reveals a few finite fixed points. Arguments are presented that the Fermi-liquid fixed point at low temperature is unstable, indicating that the impurity is overscreened, which suggests a non-Fermi-liquid phase. The impurity contributions to the specific heat, entropy, and the magnetic susceptibility are calculated in the weak coupling regime (T ≫TK ), and are compared with the analogous results obtained for the standard case of dipolar exchange interaction (the s -d Hamiltonian).

Determination of nuclear quadrupole moments – An example of the synergy of ab initio calculations and microwave spectroscopy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kellö, Vladimir

Highly correlated scalar relativistic calculations of electric field gradients at nuclei in diatomic molecules in combination with accurate nuclear quadrupole coupling constants obtained from microwave spectroscopy are used for determination of nuclear quadrupole moments.

Characterization of carbonyl by-products during Uniblu-A ozonation by liquid chromatography/hybrid quadrupole time-of-flight/mass spectrometry.

PubMed

Amorisco, A; Locaputo, V; Mascolo, G

2011-07-15

The structural elucidation of carbonyl-containing by-products arising from Uniblu-OH ozonation has been investigated by liquid chromatography/electrospray ionization tandem mass spectrometry (LC/ESI-MS/MS) employing a quadrupole time-of-flight mass spectrometer. The by-products were derivatized with 2,4-dinitrophenylhydrazine, allowing the formation of [M-H](-) ions of the derivatives in the electrospray source. Exact mass measurements of both the [M-H](-) ions and their product ions allowed the elemental formulae and related structures of ten by-products to be determined confidently. The main degradation pathway were decarboxylation followed by further oxidation. It is noteworthy that the experimental procedure employed allowed the identification of both nitrogen- and sulphur-containing carbonyl by-products during Uniblu-OH ozonation. This result is of environmental relevance for monitoring the balance of organic nitrogen and sulphur during the ozonation of organic pollutants. These atoms, in fact, do not undergo complete mineralization. Copyright © 2011 John Wiley & Sons, Ltd.

Design of an 81.25 MHz continuous-wave radio-frequency quadrupole accelerator for Low Energy Accelerator Facility

NASA Astrophysics Data System (ADS)

Ma, Wei; Lu, Liang; Xu, Xianbo; Sun, Liepeng; Zhang, Zhouli; Dou, Weiping; Li, Chenxing; Shi, Longbo; He, Yuan; Zhao, Hongwei

2017-03-01

An 81.25 MHz continuous wave (CW) radio frequency quadrupole (RFQ) accelerator has been designed for the Low Energy Accelerator Facility (LEAF) at the Institute of Modern Physics (IMP) of the Chinese Academy of Science (CAS). In the CW operating mode, the proposed RFQ design adopted the conventional four-vane structure. The main design goals are providing high shunt impendence with low power losses. In the electromagnetic (EM) design, the π-mode stabilizing loops (PISLs) were optimized to produce a good mode separation. The tuners were also designed and optimized to tune the frequency and field flatness of the operating mode. The vane undercuts were optimized to provide a flat field along the RFQ cavity. Additionally, a full length model with modulations was set up for the final EM simulations. Following the EM design, thermal analysis of the structure was carried out. In this paper, detailed EM design and thermal simulations of the LEAF-RFQ will be presented and discussed. Structure error analysis was also studied.

Second-generation coil design of the Nb 3Sn low-β quadrupole for the high luminosity LHC

DOE PAGES

Bermudez, S. Izquierdo; Ambrosio, G.; Ballarino, A.; ...

2016-01-18

As part of the Large Hadron Collider Luminosity upgrade (HiLumi-LHC) program, the US LARP collaboration and CERN are working together to design and build a 150 mm aperture Nb 3Sn quadrupole for the LHC interaction regions. A first series of 1.5 m long coils were fabricated and assembled in a first short model. A detailed visual inspection of the coils was carried out to investigate cable dimensional changes during heat treatment and the position of the windings in the coil straight section and in the end region. The analyses allow identifying a set of design changes which, combined with amore » fine tune of the cable geometry and a field quality optimization, were implemented in a new, second-generation, coil design. In this study, we review the main characteristics of the first generation coils, describe the modification in coil lay-out, and discuss their impact on parts design and magnet analysis.« less

Design of high-energy high-current linac with focusing by superconducting solenoids

DOE Office of Scientific and Technical Information (OSTI.GOV)

Batskikh, Guennady I.; Belugin, Vladimir M.; Bondarev, Boris I.

1995-09-15

The advancement of MRTI design for 1.5 GeV and 250 mA ion CW linac is presented in the report. In new linac version all the way from input to output the ions are focused by magnetic fields of superconducting solenoids. The ion limit current is far beyond the needed value. The linac focusing channel offers major advantages over the more conventional ones. The acceptance is 1.7 times as large for such focusing channel as for quadrupole one. Concurrently, a random perturbation sensitivity for such channel is one order of magnitude smaller than in quadrupole channel. These focusing channel features allowmore » to decrease beam matched radius and increase a linac radiation purity without aperture growth. ''Regotron'' is used as high power generator in linac main part. But D and W cavities need not be divided into sections connected by RF-bridges which denuded them of high coupling factor.« less

Design of high-energy high-current linac with focusing by superconducting solenoids

DOE Office of Scientific and Technical Information (OSTI.GOV)

Batskikh, G.I.; Belugin, V.M.; Bondarev, B.I.

1995-10-01

The advancement of MRTI design for 1.5 GeV and 250 mA ion CW linac was presented in a previous report. In this new linac version all the way from input to output the ions are focused by magnetic fields of superconducting solenoids. The ion limit current is far beyond the needed value. The linac focusing channel offers major advantages over the more conventional ones. The acceptance is 1.7 times as large for such focusing channel as for quadrupole one. Concurrently, a random perturbation sensitivity for such channel is one order of magnitude smaller than in quadrupole channel. These focusing channelmore » features allow to decrease beam matched radius and increase a linac radiation purity without aperture growth. {open_quotes}Regotron{close_quotes} is used as high power generator in linac main part. But D&W cavities need not be divided into sections connected by RF-bridges which denuded them of high coupling factor.« less

Practical and quality-control aspects of multi-element analysis with quadrupole ICP-MS with special attention to urine and whole blood.

PubMed

De Boer, Jan L M; Ritsema, Rob; Piso, Sjoerd; Van Staden, Hans; Van Den Beld, Wilbert

2004-07-01

Two screening methods were developed for rapid analysis of a great number of urine and blood samples within the framework of an exposure check of the population after a firework explosion. A total of 56 elements was measured including major elements. Sample preparation consisted of simple dilution. Extensive quality controls were applied including element addition and the use of certified reference materials. Relevant results at levels similar to those found in the literature were obtained for Co, Ni, Cu, Zn, Sr, Cd, Sn, Sb, Ba, Tl, and Pb in urine and for the same elements except Ni, Sn, Sb, and Ba in blood. However, quadrupole ICP-MS has limitations, mainly related to spectral interferences, for the analysis of urine and blood, and these cause higher detection limits. The general aspects discussed in the paper give it wider applicability than just for analysis of blood and urine-it can for example be used in environmental analysis.

Cold episodes in the Peruvian Central Andes: Composites, Types, and their Impacts over South America (1958-2014)

NASA Astrophysics Data System (ADS)

Sulca, J. C.; Vuille, M. F.; Roundy, P. E.; Trasmonte, G.; Silva, Y.; Takahashi, K.

2015-12-01

The Mantaro basin (MB) is located in the central Peruvian Andes. Occasionally, cold episodes are observed during austral summer (January-March), that strongly damage crops. However, little is known about the causes and impacts of such cold episodes. The main goal of this study is thus to characterize cold episodes in the MB and assess their large-scale circulation and teleconnections over South America (SA) during austral summer. To identify cold events in the MB daily minimum temperature (Tmin) for the period 1958-2014 from Huayao station, located within the MB was used. A cold episode is defined when daily minimum temperature drops below its 10-percentile for at least one day. Additionally, to study the sensitivity between physical mechanisms associated with cold episodes and temperature, cold episodes are classified in three groups: Weak cold episodes (7.5 ≤ Tmin ≤ 10 percentile), strong cold episodes (Tmin ≤ 2.5 percentile), but excluding the 9 coldest events (Tmin ≤ 0 ͦ C), henceforth referred to as extraordinary cold episodes. Several gridded reanalysis were used to characterize the large-scale circulation, cloud cover and rainfall over SA associated with these events. Weak and strong cold episodes in the MB are mainly associated with a weakening of the Bolivian High-Nordeste Low system by tropical-extratropical interactions. Both types of cold episodes are associated with westerly wind anomalies at mid- and upper-tropospheric levels aloft the Peruvian Central Andes, which inhibit the influx of humid air masses from the lowlands to the east and hence limit the development of cloud cover (e.g., positive OLR anomalies over MB). The resulting clear sky conditions cause nighttime temperatures to drop, leading to cold extremes below 10-percentile. Simultaneously, northeastern Brazil (NEB) registers negative OLR anomalies, strong convection and enhanced cloud cover because displacement of the South Atlantic Convergence Zone (SACZ) toward the northeast of its climatologic position. By contrast, extraordinary cold episodes in the MB are associated with cold and dry polar air advection at all tropospheric levels toward the central Peruvian Andes. On interannual timescales, El Niño may limit the occurrence of all types of cold episodes in the MB through enhanced tropical tropospheric background warming.

Aquarius L-Band Radiometers Calibration Using Cold Sky Observations

NASA Technical Reports Server (NTRS)

Dinnat, Emmanuel P.; Le Vine, David M.; Piepmeier, Jeffrey R.; Brown, Shannon T.; Hong, Liang

2015-01-01

An important element in the calibration plan for the Aquarius radiometers is to look at the cold sky. This involves rotating the satellite 180 degrees from its nominal Earth viewing configuration to point the main beams at the celestial sky. At L-band, the cold sky provides a stable, well-characterized scene to be used as a calibration reference. This paper describes the cold sky calibration for Aquarius and how it is used as part of the absolute calibration. Cold sky observations helped establish the radiometer bias, by correcting for an error in the spillover lobe of the antenna pattern, and monitor the long-term radiometer drift.

Differentially pumped dual linear quadrupole ion trap mass spectrometer

DOE Office of Scientific and Technical Information (OSTI.GOV)

Owen, Benjamin C.; Kenttamaa, Hilkka I.

The present disclosure provides a new tandem mass spectrometer and methods of using the same for analyzing charged particles. The differentially pumped dual linear quadrupole ion trap mass spectrometer of the present disclose includes a combination of two linear quadrupole (LQIT) mass spectrometers with differentially pumped vacuum chambers.

Stabilization of the electron-nuclear spin orientation in quantum dots by the nuclear quadrupole interaction.

PubMed

Dzhioev, R I; Korenev, V L

2007-07-20

The nuclear quadrupole interaction eliminates the restrictions imposed by hyperfine interaction on the spin coherence of an electron and nuclei in a quantum dot. The strain-induced nuclear quadrupole interaction suppresses the nuclear spin flip and makes possible the zero-field dynamic nuclear polarization in self-organized InP/InGaP quantum dots. The direction of the effective nuclear magnetic field is fixed in space, thus quenching the magnetic depolarization of the electron spin in the quantum dot. The quadrupole interaction suppresses the zero-field electron spin decoherence also for the case of nonpolarized nuclei. These results provide a new vision of the role of the nuclear quadrupole interaction in nanostructures: it elongates the spin memory of the electron-nuclear system.

Stabilization of the Electron-Nuclear Spin Orientation in Quantum Dots by the Nuclear Quadrupole Interaction

NASA Astrophysics Data System (ADS)

Dzhioev, R. I.; Korenev, V. L.

2007-07-01

The nuclear quadrupole interaction eliminates the restrictions imposed by hyperfine interaction on the spin coherence of an electron and nuclei in a quantum dot. The strain-induced nuclear quadrupole interaction suppresses the nuclear spin flip and makes possible the zero-field dynamic nuclear polarization in self-organized InP/InGaP quantum dots. The direction of the effective nuclear magnetic field is fixed in space, thus quenching the magnetic depolarization of the electron spin in the quantum dot. The quadrupole interaction suppresses the zero-field electron spin decoherence also for the case of nonpolarized nuclei. These results provide a new vision of the role of the nuclear quadrupole interaction in nanostructures: it elongates the spin memory of the electron-nuclear system.

A -cation control of magnetoelectric quadrupole order in A (TiO)Cu 4(PO4)4(A =Ba ,Sr, and Pb)

NASA Astrophysics Data System (ADS)

Kimura, K.; Toyoda, M.; Babkevich, P.; Yamauchi, K.; Sera, M.; Nassif, V.; Rønnow, H. M.; Kimura, T.

2018-04-01

Ferroic magnetic quadrupole order exhibiting macroscopic magnetoelectric activity is discovered in the novel compound A (TiO ) Cu4(PO4)4 with A = Pb, which is in contrast with antiferroic quadrupole order observed in the isostructural compounds with A = Ba and Sr. Unlike the famous lone-pair stereochemical activity which often triggers ferroelectricity as in PbTiO3, the Pb2 + cation in Pb (TiO ) Cu4(PO4)4 is stereochemically inactive but dramatically alters specific magnetic interactions and consequently switches the quadrupole order from antiferroic to ferroic. Our first-principles calculations uncover a positive correlation between the degree of A -O bond covalency and a stability of the ferroic quadrupole order.

Highly Dynamic Anion-Quadrupole Networks in Proteins.

PubMed

Kapoor, Karan; Duff, Michael R; Upadhyay, Amit; Bucci, Joel C; Saxton, Arnold M; Hinde, Robert J; Howell, Elizabeth E; Baudry, Jerome

2016-11-01

The dynamics of anion-quadrupole (or anion-π) interactions formed between negatively charged (Asp/Glu) and aromatic (Phe) side chains are for the first time computationally characterized in RmlC (Protein Data Bank entry 1EP0 ), a homodimeric epimerase. Empirical force field-based molecular dynamics simulations predict anion-quadrupole pairs and triplets (anion-anion-π and anion-π-π) are formed by the protein during the simulated trajectory, which suggests that the anion-quadrupole interactions may provide a significant contribution to the overall stability of the protein, with an average of -1.6 kcal/mol per pair. Some anion-π interactions are predicted to form during the trajectory, extending the number of anion-quadrupole interactions beyond those predicted from crystal structure analysis. At the same time, some anion-π pairs observed in the crystal structure exhibit marginal stability. Overall, most anion-π interactions alternate between an "on" state, with significantly stabilizing energies, and an "off" state, with marginal or null stabilizing energies. The way proteins possibly compensate for transient loss of anion-quadrupole interactions is characterized in the RmlC aspartate 84-phenylalanine 112 anion-quadrupole pair observed in the crystal structure. A double-mutant cycle analysis of the thermal stability suggests a possible loss of anion-π interactions compensated by variations of hydration of the residues and formation of compensating electrostatic interactions. These results suggest that near-planar anion-quadrupole pairs can exist, sometimes transiently, which may play a role in maintaining the structural stability and function of the protein, in an otherwise very dynamic interplay of a nonbonded interaction network as well as solvent effects.

Aharonov–Anandan quantum phases and Landau quantization associated with a magnetic quadrupole moment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fonseca, I.C.; Bakke, K., E-mail: kbakke@fisica.ufpb.br

The arising of geometric quantum phases in the wave function of a moving particle possessing a magnetic quadrupole moment is investigated. It is shown that an Aharonov–Anandan quantum phase (Aharonov and Anandan, 1987) can be obtained in the quantum dynamics of a moving particle with a magnetic quadrupole moment. In particular, it is obtained as an analogue of the scalar Aharonov–Bohm effect for a neutral particle (Anandan, 1989). Besides, by confining the quantum particle to a hard-wall confining potential, the dependence of the energy levels on the geometric quantum phase is discussed and, as a consequence, persistent currents can arisemore » from this dependence. Finally, an analogue of the Landau quantization is discussed. -- Highlights: •Scalar Aharonov–Bohm effect for a particle possessing a magnetic quadrupole moment. •Aharonov–Anandan quantum phase for a particle with a magnetic quadrupole moment. •Dependence of the energy levels on the Aharonov–Anandan quantum phase. •Landau quantization associated with a particle possessing a magnetic quadrupole moment.« less

Nonuniform radiation damage in permanent magnet quadrupoles.

PubMed

Danly, C R; Merrill, F E; Barlow, D; Mariam, F G

2014-08-01

We present data that indicate nonuniform magnetization loss due to radiation damage in neodymium-iron-boron Halbach-style permanent magnet quadrupoles. The proton radiography (pRad) facility at Los Alamos uses permanent-magnet quadrupoles for magnifying lenses, and a system recently commissioned at GSI-Darmsdadt uses permanent magnets for its primary lenses. Large fluences of spallation neutrons can be produced in close proximity to these magnets when the proton beam is, intentionally or unintentionally, directed into the tungsten beam collimators; imaging experiments at LANL's pRad have shown image degradation with these magnetic lenses at proton beam doses lower than those expected to cause damage through radiation-induced reduction of the quadrupole strength alone. We have observed preferential degradation in portions of the permanent magnet quadrupole where the field intensity is highest, resulting in increased high-order multipole components.

Communication: On the isotope anomaly of nuclear quadrupole coupling in molecules

NASA Astrophysics Data System (ADS)

Filatov, Michael; Zou, Wenli; Cremer, Dieter

2012-10-01

The dependence of the nuclear quadrupole coupling constants (NQCC) on the interaction between electrons and a nucleus of finite size is theoretically analyzed. A deviation of the ratio of the NQCCs obtained from two different isotopomers of a molecule from the ratio of the corresponding bare nuclear electric quadrupole moments, known as quadrupole anomaly, is interpreted in terms of the logarithmic derivatives of the electric field gradient at the nuclear site with respect to the nuclear charge radius. Quantum chemical calculations based on a Dirac-exact relativistic methodology suggest that the effect of the changing size of the Au nucleus in different isotopomers can be observed for Au-containing molecules, for which the predicted quadrupole anomaly reaches values of the order of 0.1%. This is experimentally detectable and provides an insight into the charge distribution of non-spherical nuclei.

Exact cancellation of emittance growth due to coupled transverse dynamics in solenoids and rf couplers

NASA Astrophysics Data System (ADS)

Dowell, David H.; Zhou, Feng; Schmerge, John

2018-01-01

Weak, rotated magnetic and radio frequency quadrupole fields in electron guns and injectors can couple the beam's horizontal with vertical motion, introduce correlations between otherwise orthogonal transverse momenta, and reduce the beam brightness. This paper discusses two important sources of coupled transverse dynamics common to most electron injectors. The first is quadrupole focusing followed by beam rotation in a solenoid, and the second coupling comes from a skewed high-power rf coupler or cavity port which has a rotated rf quadrupole field. It is shown that a dc quadrupole field can correct for both types of couplings and exactly cancel their emittance growths. The degree of cancellation of the rf skew quadrupole emittance is limited by the electron bunch length. Analytic expressions are derived and compared with emittance simulations and measurements.

Cold chain monitoring during cold transportation of human corneas for transplantation.

PubMed

Net, M; Trias, E; Navarro, A; Ruiz, A; Diaz, P; Fontenla, J R; Manyalich, M

2003-08-01

As recommended by international standards the cornea should be maintained in a specific temperature range (2 degrees -8 degrees C) to guarantee its viability. However, there is no standard packaging method to maintain these conditions during transport. Our packaging system is similar to those used by the main eye banks in Spain and elsewhere in Europe. The objective is to monitor the cold chain in the current packaging method to validate the maintenance of temperature within the adequate range for a minimum 24-hour period. The effects of the following variables were studied: number and freezing temperature of the cold packs; air volume in the packaging system; position of the cornea in the packaging system; and the wall section of the container. Exterior temperature was maintained constant at 20 degrees to 24 degrees C. The cold chain was monitored using a device that measures temperature continuously and for which a histogram of temperature variation can be downloaded to a computer for further analysis. When the cold packs were frozen to -40 degrees C or the number of cold packs increased to four, the temperature decreased quickly to 0 degrees C and the transport period was not prolonged. The main objective was to improve isolation by reducing inner air volume, and maintaining the position of the cornea in the container. The currently used cold packaging systems (not frozen, 4 degrees C) do not maintain the temperature within the accepted range for the required distribution period. The improved system maintains the cornea at between 2 degrees C and 6 degrees C for a minimum of 24 hours.

Qualitative analysis of seized synthetic cannabinoids and synthetic cathinones by gas chromatography triple quadrupole tandem mass spectrometry.

PubMed

Gwak, Seongshin; Arroyo-Mora, Luis E; Almirall, José R

2015-02-01

Designer drugs are analogues or derivatives of illicit drugs with a modification of their chemical structure in order to circumvent current legislation for controlled substances. Designer drugs of abuse have increased dramatically in popularity all over the world for the past couple of years. Currently, the qualitative seized-drug analysis is mainly performed by gas chromatography-electron ionization-mass spectrometry (GC-EI-MS) in which most of these emerging designer drug derivatives are extensively fragmented not presenting a molecular ion in their mass spectra. The absence of molecular ion and/or similar fragmentation pattern among these derivatives may cause the equivocal identification of unknown seized-substances. In this study, the qualitative identification of 34 designer drugs, mainly synthetic cannabinoids and synthetic cathinones, were performed by gas chromatography-triple quadrupole-tandem mass spectrometry with two different ionization techniques, including electron ionization (EI) and chemical ionization (CI) only focusing on qualitative seized-drug analysis, not from the toxicological point of view. The implementation of CI source facilitates the determination of molecular mass and the identification of seized designer drugs. Developed multiple reaction monitoring (MRM) mode may increase sensitivity and selectivity in the analysis of seized designer drugs. In addition, CI mass spectra and MRM mass spectra of these designer drug derivatives can be used as a potential supplemental database along with EI mass spectral database. Copyright © 2014 John Wiley & Sons, Ltd.

Electrostatic quadrupole focused particle accelerating assembly with laminar flow beam

DOEpatents

Maschke, A.W.

1984-04-16

A charged particle accelerating assembly provided with a predetermined ratio of parametric structural characteristics and with related operating voltages applied to each of its linearly spaced focusing and accelerating quadrupoles, thereby to maintain a particle beam traversing the electrostatic fields of the quadrupoles in the assembly in an essentially laminar flow through the assembly.

Electrostatic quadrupole focused particle accelerating assembly with laminar flow beam

DOEpatents

Maschke, Alfred W.

1985-01-01

A charged particle accelerating assembly provided with a predetermined ratio of parametric structural characteristics and with related operating voltages applied to each of its linearly spaced focusing and accelerating quadrupoles, thereby to maintain a particle beam traversing the electrostatic fields of the quadrupoles in the assembly in an essentially laminar flow throughout the assembly.

The Columbia University Sub-micron Charged Particle Beam

PubMed Central

Randers-Pehrson, Gerhard; Johnson, Gary W.; Marino, Stephen A.; Xu, Yanping; Dymnikov, Alexander D.; Brenner, David J.

2009-01-01

A lens system consisting of two electrostatic quadrupole triplets has been designed and constructed at the Radiological Research Accelerator Facility (RARAF) of Columbia University. The lens system has been used to focus 6-MeV 4He ions to a beam spot in air with a diameter of 0.8 µm. The quadrupole electrodes can withstand voltages high enough to focus 4He ions up to 10 MeV and protons up to 5 MeV. The quadrupole triplet design is novel in that alignment is made through precise construction and the relative strengths of the quadrupoles are accomplished by the lengths of the elements, so that the magnitudes of the voltages required for focusing are nearly identical. The insulating sections between electrodes have had ion implantation to improve the voltage stability of the lens. The lens design employs Russian symmetry for the quadrupole elements. PMID:20161365

Exact cancellation of emittance growth due to coupled transverse dynamics in solenoids and rf couplers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dowell, David H.; Zhou, Feng; Schmerge, John

Weak, rotated magnetic and radio frequency quadrupole fields in electron guns and injectors can couple the beam’s horizontal with vertical motion, introduce correlations between otherwise orthogonal transverse momenta, and reduce the beam brightness. This paper discusses two important sources of coupled transverse dynamics common to most electron injectors. The first is quadrupole focusing followed by beam rotation in a solenoid, and the second coupling comes from a skewed high-power rf coupler or cavity port which has a rotated rf quadrupole field. It is shown that a dc quadrupole field can correct for both types of couplings and exactly cancel theirmore » emittance growths. The degree of cancellation of the rf skew quadrupole emittance is limited by the electron bunch length. Analytic expressions are derived and compared with emittance simulations and measurements.« less

Exact cancellation of emittance growth due to coupled transverse dynamics in solenoids and rf couplers

DOE PAGES

Dowell, David H.; Zhou, Feng; Schmerge, John

2018-01-17

Weak, rotated magnetic and radio frequency quadrupole fields in electron guns and injectors can couple the beam’s horizontal with vertical motion, introduce correlations between otherwise orthogonal transverse momenta, and reduce the beam brightness. This paper discusses two important sources of coupled transverse dynamics common to most electron injectors. The first is quadrupole focusing followed by beam rotation in a solenoid, and the second coupling comes from a skewed high-power rf coupler or cavity port which has a rotated rf quadrupole field. It is shown that a dc quadrupole field can correct for both types of couplings and exactly cancel theirmore » emittance growths. The degree of cancellation of the rf skew quadrupole emittance is limited by the electron bunch length. Analytic expressions are derived and compared with emittance simulations and measurements.« less

Theory of Nuclear Quadrupole Interactions in the Chemical Ferromagnet p-Cl-Ph-CH-N=TEMPO

NASA Astrophysics Data System (ADS)

Briere, Tina M.; Jeong, Junho; Sahoo, N.; Das, T. P.; Ohira, S.; Nishiyama, K.; Nagamine, K.

2002-03-01

The study(Junho Jeong et al., Physica B 289-290, 132 (2000).) of the magnetic hyperfine properties of chemical ferromagnets provides valuable information about the electronic spin distributions in the individual molecules. Insights into the electronic charge distributions and their anisotropy can be obtained from electric quadrupole interactions for the different nuclei in these systems. For this purpose we have studied the nuclear quadrupole interactions(T. P. Das and E. L. Hahn "Nuclear Quadrupole Resonance Spectroscopy", Academic Press Inc., New York, 1958.) for the 14^N nuclei in the NO group and the bridge nitrogen, the 17^O nucleus in the NO group and the 35^Cl nucleus in the p-Cl-Ph-CH-N=TEMPO system both by itself and in the presence of trapped μ and Mu. Comparison will be made between our results and available experimental quadrupole coupling constant (e^2qQ) and asymmetry parameter (η) data.

Investigation of the cold drops in the European area, study based on ERA Interim and ECMWF ensemble model

NASA Astrophysics Data System (ADS)

Gaal, Nikolett; Ihasz, Istvan

2013-04-01

We aimed to analyze the cold drops and the upper level lows formed in the middle troposphere - which are often difficult to be predicted - by means of the statistical methods and case studies. Cold drops are often followed by intensive events such as heavy rainfall, rainstorm, at times tubas and non mesocyclonical tornadoes. Due to the above mentioned events and the incentive of Aviation and Severe Weather Forecasting Division at Hungarian Meteorological Service, the phenomenon was analyzed in a complex way by a self-developed multiple method. Upper-Level Lows (ULL-s) are closed; cyclonically circulating eddies isolated from the main western stream in the middle and upper troposphere. They are also sometimes called "cold drops" because the air within an Upper Level low is colder than in its surroundings. The cold air within usually does not show up on the surface, meaning the vertical temperature gradient is high, which in turn causes instability and heavy storms, especially during the summer. An ULL-s diameter is about a couple hundred km-s, so it looks like a miniature cyclone. ERA INTERIM is the current state of reanalysis that is still in development. It also has the best possible spatial resolution, which leads to its usage in a wide area of fields. Our studies focused mainly on the cold drops' statistics and meteorology, as well as a few case studies. Since ULL's occur rarely, we developed a new ULL-recognition process to increase the number of samples available. First of all, we gathered 70days when cold drops occurred in the past 10 years. Then we analyzed them in 6-hour periods, for a total of 280 separate time periods. Finally, we have four main case studies in the paper. In the future, we would like to run further tests with our ULL-recognition algorithm to study the last 30 years of cold drops, and we would also like to experiment more with ULL forecasting as well.

Rapid analysis of the main components of the total glycosides of Ranunculus japonicus by UPLC/Q-TOF-MS.

PubMed

Rui, Wen; Chen, Hongyuan; Tan, Yuzhi; Zhong, Yanmei; Feng, Yifan

2010-05-01

A rapid method for the analysis of the main components of the total glycosides of Ranunculus japonicus (TGOR) was developed using ultra-performance liquid chromatography with quadrupole-time-of-flight mass spectrometry (UPLC/Q-TOF-MS). The separation analysis was performed on a Waters Acquity UPLC system and the accurate mass of molecules and their fragment ions were determined by Q-TOF MS. Twenty compounds, including lactone glycosides, flavonoid glycosides and flavonoid aglycones, were identified and tentatively deduced on the basis of their elemental compositions, MS/MS data and relevant literature. The results demonstrated that lactone glycosides and flavonoids were the main constituents of TGOR. Furthermore, an effective and rapid pattern was established allowing for the comprehensive and systematic characterization of the complex samples.

Compensation of orbit distortion due to quadrupole motion using feed-forward control at KEK ATF

NASA Astrophysics Data System (ADS)

Bett, D. R.; Charrondière, C.; Patecki, M.; Pfingstner, J.; Schulte, D.; Tomás, R.; Jeremie, A.; Kubo, K.; Kuroda, S.; Naito, T.; Okugi, T.; Tauchi, T.; Terunuma, N.; Burrows, P. N.; Christian, G. B.; Perry, C.

2018-07-01

The high luminosity requirement for a future linear collider sets a demanding limit on the beam quality at the Interaction Point (IP). One potential source of luminosity loss is the motion of the ground itself. The resulting misalignments of the quadrupole magnets cause distortions to the beam orbit and hence an increase in the beam emittance. This paper describes a technique for compensating this orbit distortion by using seismometers to monitor the misalignment of the quadrupole magnets in real-time. The first demonstration of the technique was achieved at the Accelerator Test Facility (ATF) at KEK in Japan. The feed-forward system consisted of a seismometer-based quadrupole motion monitoring system, an FPGA-based feed-forward processor and a stripline kicker plus associated electronics. Through the application of a kick calculated from the position of a single quadruple, the system was able to remove about 80% of the component of the beam jitter that was correlated to the motion of the quadrupole. As a significant fraction of the orbit jitter in the ATF final focus is due to sources other than quadrupole misalignment, this amounted to an approximately 15% reduction in the absolute beam jitter.

Ultraviolet Photodissociation Spectroscopy of the Cold K⁺·Calix[4]arene Complex in the Gas Phase.

PubMed

Inokuchi, Yoshiya; Soga, Kazuki; Hirai, Kenta; Kida, Motoki; Morishima, Fumiya; Ebata, Takayuki

2015-08-06

The cooling of ionic species in the gas phase greatly simplifies the UV spectrum, which is of special importance when studying the electronic and geometric structures of large systems, such as biorelated molecules and host-guest complexes. Many efforts have been devoted to achieving ion cooling with a cold, quadrupole Paul ion trap (QIT), but one problem was the insufficient cooling of ions (up to ∼30 K) in the QIT. In this study, we construct a mass spectrometer for the ultraviolet photodissociation (UVPD) spectroscopy of gas-phase cold ions. The instrument consists of an electrospray ion source, a QIT cooled with a He cryostat, and a time-of-flight mass spectrometer. With great care given to the cooling condition, we can achieve ∼10 K for the vibrational temperature of ions in the QIT, which is estimated from UVPD spectra of the benzo-18-crown-6 (B18C6) complex with a potassium ion, K(+)·B18C6. Using this setup, we measure a UVPD spectrum of cold calix[4]arene (C4A) complex with potassium ion, K(+)·C4A. The spectrum shows a very weak band and a strong one at 36018 and 36156 cm(-1), respectively, accompanied by many sharp vibronic bands in the 36000-36600 cm(-1) region. In the geometry optimization of the K(+)·C4A complex, we obtain three stable isomers: one endo and two exo forms. On the basis of the total energy and UV spectral patterns predicted by density functional theory calculations, we attribute the structure of the K(+)·C4A complex to the endo isomer (C2 symmetry), in which the K(+) ion is located inside the cup of C4A. The vibronic bands of K(+)·C4A at 36 018 and 36 156 cm(-1) are assigned to the S1(A)-S0(A) and S2(B)-S0(A) transitions of the endo isomer, respectively.

Leakage of power from dipole to higher multipoles due to non-symmetric beam shape of the CMB missions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Das, Santanu; Souradeep, Tarun, E-mail: santanud@iucaa.ernet.in, E-mail: tarun@iucaa.ernet.in

2015-05-01

A number of studies of WMAP and Planck claimed the low multipole (specially quadrupole) power deficiency in CMB power spectrum. Anomaly in the orientations of the low multipoles have also been claimed. There is a possibility that the power deficiency at low multipoles may not be of primordial origin and is only an observation artifact coming from the scan procedure adapted in the WMAP or Planck satellites. Therefore, it is always important to investigate all the observational artifacts that can mimic them. The CMB dipole which is much higher than the quadrupole can leak to the higher multipoles due tomore » the non-symmetric beam shape of the WMAP or Planck. We observe that a non-negligible amount of power from the dipole can get transferred to the quadrupole and the higher multipoles due to the non-symmetric beam shapes and contaminate the observed measurements. The orientation of the quadrupole generated by this power transfer is surprisingly very close to the quadrupole observed from the WMAP and Planck maps. However, our analysis shows that the orientation of the quadrupole can not be explained using only the dipole power leakage. In this paper we calculate the amount of quadrupole power leakage for different WMAP bands. For Planck we present the results in terms of upper limits on asymmetric beam parameters that can lead to significant amount of power leakage.« less

Amino acid and glucose uptake by rat brown adipose tissue. Effect of cold-exposure and acclimation.

PubMed Central

López-Soriano, F J; Fernández-López, J A; Mampel, T; Villarroya, F; Iglesias, R; Alemany, M

1988-01-01

The net uptake/release of glucose, lactate and amino acids from the bloodstream by the interscapular brown adipose tissue of control, cold-exposed and cold-acclimated rats was estimated by measurement of arteriovenous differences in their concentrations. In the control animals amino acids contributed little to the overall energetic needs of the tissue; glucose uptake was more than compensated by lactate efflux. Cold-exposure resulted in an enhancement of amino acid utilization and of glucose uptake, with high lactate efflux. There was a net glycine and proline efflux that partly compensated the positive nitrogen balance of the tissue; amino acids accounted for about one-third of the energy supplied by glucose to the tissue. Cold-acclimation resulted in a very high increase in glucose uptake, with a parallel decrease in lactate efflux and amino acid consumption. Branched-chain amino acids, however, were more actively utilized. This was related with a much higher alanine efflux, in addition to that of glycine and proline. It is suggested that most of the glucose used during cold-exposure is returned to the bloodstream as lactate under conditions of active lipid utilization, amino acids contributing their skeletons largely in anaplerotic pathways. On the other hand, cold-acclimation resulted in an important enhancement of glucose utilization, with lowered amino acid oxidation. Amino acids are thus used as metabolic substrates by the brown adipose tissue of rats under conditions of relatively scarce substrate availability, but mainly as anaplerotic substrates, in parallel to glucose. Cold-acclimation results in a shift of the main substrates used in thermogenesis from lipid to glucose, with a much lower need for amino acids. PMID:3421924

Permanent magnet edge-field quadrupole

DOEpatents

Tatchyn, R.O.

1997-01-21

Planar permanent magnet edge-field quadrupoles for use in particle accelerating machines and in insertion devices designed to generate spontaneous or coherent radiation from moving charged particles are disclosed. The invention comprises four magnetized rectangular pieces of permanent magnet material with substantially similar dimensions arranged into two planar arrays situated to generate a field with a substantially dominant quadrupole component in regions close to the device axis. 10 figs.

Permanent magnet edge-field quadrupole

DOEpatents

Tatchyn, Roman O.

1997-01-01

Planar permanent magnet edge-field quadrupoles for use in particle accelerating machines and in insertion devices designed to generate spontaneous or coherent radiation from moving charged particles are disclosed. The invention comprises four magnetized rectangular pieces of permanent magnet material with substantially similar dimensions arranged into two planar arrays situated to generate a field with a substantially dominant quadrupole component in regions close to the device axis.

Investigating a Quadrant Surface Coil Array for NQR Remote Sensing

DTIC Science & Technology

2014-10-23

UNCLASSIFIED 1  Abstract—this paper is on the design and fabrication of a surface coil array in a quadrant layout for NQR (Nuclear Quadrupole...coupling and SNR (Signal-to-Noise Ratio) at standoff distances perpendicular from each coil. Index Terms— Nuclear Quadrupole Resonance, NQR ...Coil Array, probe, Nuclear Magnetic Resonance, tuning, decoupling, RLC, mutual coupling, RLC I. INTRODUCTION N Nuclear quadrupole resonance ( NQR

Chemical (knight) shift distortions of quadrupole-split deuteron powder spectra in solids

NASA Astrophysics Data System (ADS)

Torgeson, D. R.; Schoenberger, R. J.; Barnes, R. G.

In strong magnetic fields (e.g., 8 Tesla) anisotropy of the shift tensor (chemical or Knight shift) can alter the spacings of the features of quadrupole-split deuteron spectra of polycrystalline samples. Analysis of powder spectra yields both correct quadrupole coupling and symmetry parameters and all the components of the shift tensor. Synthetic and experimental examples are given to illustrate such behavior.

75 FR 59181 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-27

... of Cold State Route 9D. Spring, Village of Nelsonville. Approximately 852 feet None +369 upstream of... Approximately 500 feet +218 +219 Town of Putnam Valley. upstream of the confluence with Peekskill Hollow Creek... Philipstown Maps are available for inspection at the Philipstown Town Hall, 238 Main Street, Cold Spring, NY...

Are the low-lying isovector 1 + states scissors vibrations?

NASA Astrophysics Data System (ADS)

Faessler, A.

At the Technische Hochschule in Darmstadt the group of Richter and coworkers found in 1983/84 in deformed rare earth nuclei low-lying isovector 1 + states. Such states have been predicted in the generalized Bohr-Mottelson model and in the interacting boson model no. 2 (IBA2). In the generalized Bohr-Mottelson model one allows for proton and neutron quadrupole deformations separately. If one includes only static proton and neutron deformations the generalized Bohr-Mottelson model reduces to the two rotor model. It describes the excitation energy of these states in good agreement with the data but overestimates the magnetic dipole transition probabilities by a factor 5. In the interacting boson model (IBA2) where only the outermost nucleons participate in the excitation the magnetic dipole transition probability is only overestimated by a factor 2. The too large collectivity in both models results from the fact that they concentrate the whole strength of the scissors vibrations into one state. A microscopic description is needed to describe the spreading of the scissors strength over several states. For a microscopic determination of these scissors states one uses the Quasi-particle Random Phase Approximation (QRPA). But this approach has a serious difficulty. Since one rotates for the calculation the nucleus into the intrinsic system the state corresponding to the rotation of the whole nucleus is a spurious state. The usual procedure to remove this spuriosity is to use the Thouless theorem which says that a spurious state created by an operator which commutes with the total hamiltonian (here the total angular momentum, corresponding to a rotation of the whole system) produces the spurious state if applied to the ground state. It says further the energy of this spurious state lies at zero excitation energy (it is degenerate with the ground state) and is orthogonal to all physical states. Thus the usual approach is to vary the quadrupole-quadrupole force strength so that a state lies at zero excitation energy and to identify that with the spuríous state. This procedure assumes that a total angular momentum commutes with a total hamiltonian. But this is not the case since the total hamiltonian contains a deformed Saxon-Woods potential. Thus one has to take care explicitly that the spurious state is removed. This we do in our approach by introducing Lagrange multipliers for each excited states and requesting that these states are orthogonal to the spurious state which is explicitly constructed by applying the total angular momentum operator to the ground state. To reduce the number of free parameters in the hamiltonian we take the Saxon-Woods potential for the deformed nuclei from the literature (with minor adjustments) and determine the proton-proton, neutron-neutron and the proton-neutron quadrupole force constant by requesting that the hamiltonian commutes with the total angular momentum in the (QRPA) ground state. This yields equations fixing all three coupling constants for the quadrupole-quadrupole force allowing even for isospin symmetry violation. The spin-spin force is taken from the Reid soft core potential. A possible spin-quadrupole force has been taken from the work of Soloviev but it turns out that this is not important. The calculation shows that the strength of the scissors vibrations are spread over many states. The main 1 + state at around 3 MeV has an overlap of the order of 14 % of the scissors state. 50% of that state are spread over the physical states up to an excitation energy of 6 MeV. The rest is distributed over higher lying states. The expectation value of the many-body hamiltonian in the scissors vibrational state shows roughly an excitation energy of 7 MeV above the ground state. The results also support the experimental findings that these states are mainly orbital excitations. States are not very collective. Normally only a proton and neutron particle-hole pair are with a large amplitude participating in forming these states. But those protons and neutrons which are excited perform scissors type vibrations.

Analysis of non-steroidal anti-inflammatory drugs in milk using QuEChERS and liquid chromatography coupled to mass spectrometry: triple quadrupole versus Q-Orbitrap mass analyzers.

PubMed

Rúbies, Antoni; Guo, Lili; Centrich, Francesc; Granados, Mercè

2016-08-01

We developed a Quick, Easy, Cheap, Effective, Rugged, and Safe (QuEChERS) method for the high throughput determination of 10 non-steroidal anti-inflammatory drugs (NSAIDs) in milk samples using high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) with a triple quadrupole (QqQ) instrument and an electrospray ionization (ESI) source. The new extraction procedure is highly efficient, and we obtained absolute recoveries in the range 78.1-97.1 % for the extraction and clean-up steps. Chromatographic separation is performed in the gradient mode with a biphenyl column and acidic mobile phases consisting of water and acetonitrile containing formic acid. The chromatographic run time was about 12 min, and NSAID peaks showed a good symmetry factor. For MS/MS detection, we used multiple reaction monitoring (MRM) mode, using ESI in both positive and negative modes. Our method has been validated in compliance with the European Commission Decision 657/2002/EC, and we obtained very satisfactory results in inter-laboratory testing. Furthermore, we explored the use of a hybrid high resolution mass spectrometer, combining a quadrupole and an Orbitrap mass analyzer, for high resolution (HR) MS/MS detection of NSAIDs. We achieved lower NSAID quantification limits with Q-Orbitrap high resolution mass spectrometry (HRMS/MS) detection than those achieved with the QqQ instrument; however, its main feature is its very high selectivity, which makes HRMS/MS particularly suitable for confirmatory analysis.

Low energy ion beam dynamics of NANOGAN ECR ion source

NASA Astrophysics Data System (ADS)

Kumar, Sarvesh; Mandal, A.

2016-04-01

A new low energy ion beam facility (LEIBF) has been developed for providing the mass analyzed highly charged intense ion beams of energy ranging from a few tens of keV to a few MeV for atomic, molecular and materials sciences research. The new facility consists of an all permanent magnet 10 GHz electron cyclotron resonance (ECR) ion source (NANOGAN) installed on a high voltage platform (400 kV) which provides large currents of multiply charged ion beams. Higher emittance at low energy of intense ion beam puts a tremendous challenge to the beam optical design of this facility. The beam line consists of mainly the electrostatic quadrupoles, an accelerating section, analyzing cum switching magnet and suitable beam diagnostics including vacuum components. The accelerated ion beam is analyzed for a particular mass to charge (m/q) ratio as well as guided to three different lines along 75°, 90° and 105° using a large acceptance analyzing cum switching magnet. The details of transverse beam optics to all the beam lines with TRANSPORT and GICOSY beam optics codes are being described. Field computation code, OPERA 3D has been utilized to design the magnets and electrostatic quadrupoles. A theoretical estimation of emittance for optimized geometry of ion source is given so as to form the basis of beam optics calculations. The method of quadrupole scan of the beam is used to characterize the emittance of the final beam on the target. The measured beam emittance increases with m/q ratios of various ion beams similar to the trend observed theoretically.

Seismic equivalents of volcanic jet scaling laws and multipoles in acoustics

NASA Astrophysics Data System (ADS)

Haney, Matthew M.; Matoza, Robin S.; Fee, David; Aldridge, David F.

2018-04-01

We establish analogies between equivalent source theory in seismology (moment-tensor and single-force sources) and acoustics (monopoles, dipoles and quadrupoles) in the context of volcanic eruption signals. Although infrasound (acoustic waves < 20 Hz) from volcanic eruptions may be more complex than a simple monopole, dipole or quadrupole assumption, these elementary acoustic sources are a logical place to begin exploring relations with seismic sources. By considering the radiated power of a harmonic force source at the surface of an elastic half-space, we show that a volcanic jet or plume modelled as a seismic force has similar scaling with respect to eruption parameters (e.g. exit velocity and vent area) as an acoustic dipole. We support this by demonstrating, from first principles, a fundamental relationship that ties together explosion, torque and force sources in seismology and highlights the underlying dipole nature of seismic forces. This forges a connection between the multipole expansion of equivalent sources in acoustics and the use of forces and moments as equivalent sources in seismology. We further show that volcanic infrasound monopole and quadrupole sources exhibit scalings similar to seismicity radiated by volume injection and moment sources, respectively. We describe a scaling theory for seismic tremor during volcanic eruptions that agrees with observations showing a linear relation between radiated power of tremor and eruption rate. Volcanic tremor over the first 17 hr of the 2016 eruption at Pavlof Volcano, Alaska, obeyed the linear relation. Subsequent tremor during the main phase of the eruption did not obey the linear relation and demonstrates that volcanic eruption tremor can exhibit other scalings even during the same eruption.

North-South Asymmetric Solar Cycle Evolution: Signatures in the Photosphere and Consequences in the Corona

NASA Astrophysics Data System (ADS)

Virtanen, I. I.; Mursula, K.

2014-02-01

The heliospheric current sheet is the continuum of the coronal magnetic equator that divides the heliospheric magnetic field into two sectors (polarities). Several recent studies have shown that the heliospheric current sheet is southward shifted during approximately 3 years in the solar declining phase (the so-called bashful ballerina phenomenon). In this article we study the hemispherical asymmetry in the photospheric and coronal magnetic fields using Wilcox Solar Observatory measurements of the photospheric magnetic field since 1976 as well as the potential field source surface model. Multipole analysis of the photospheric magnetic field shows that during the late declining phase of solar cycles since the 1970s, the "bashful ballerina phenomenon" is a consequence of the g^{0}_{2} quadrupole term, signed oppositely to the dipole moment. Surges of new flux transport magnetic field from low latitudes to the poles, thus leading to a systematically varying contribution to the g^{0}_{2}-term from different latitudes. In the case of a north-south asymmetric flux production, this is seen as a quadrupole contribution traveling toward higher latitudes. When the quadrupole term is largest, the main contribution comes from the polar latitudes. At least during the four recent solar cycles, the g^{0}_{2}-term arises because the magnitude of the southern polar field is larger than the magnitude found in the north in the declining phase of the cycle. In the heliosphere this hemispheric asymmetry of the coronal fields is seen as a southward shift of the heliospheric current sheet by about 2°.

North south asymmetry in the coronal and photospheric magnetic fields

NASA Astrophysics Data System (ADS)

Virtanen, I.; Mursula, K.

2013-12-01

Several recent studies have shown that the Heliospheric current sheet (HCS) is southward shifted during about three years in the solar declining phase (the so-called bashful ballerina phenomenon). We study the hemispherical asymmetry in the photospheric and coronal magnetic fields using Wilcox Solar Observatory (WSO) measurements of the photospheric magnetic field since 1976 and the potential field source surface (PFSS) model. Multipole analysis of the photospheric magnetic field shows that during the late declining phase of solar cycles since 1970s, bashful ballerina phenomenon is a consequence of g02 quadrupole term, signed oppositely to the dipole moment. Surges of new flux transport magnetic field from low latitudes to the poles, thus leading to a systematically varying contribution to the g02-term from different latitudes. In the case of a north-south asymmetric flux production this is seen as a quadrupole contribution traveling towards higher latitudes. When the quadrupole term is largest the main contribution comes from the polar latitudes. At least during the four recent solar cycles the g02-term arises because the magnitude of the southern polar field is larger than in the north in the declining phase of the cycle. Magnetic flux is transported polewards by the meridional flow and it is most likely that besides the north-south asymmetric production of the magnetic flux, also the asymmetric transportation may significantly contribute to the observed asymmetry of polar field intensities. The overall activity during solar cycle is not significantly different in the northern and southern hemispheres, but hemispheres tend to develop in a different phase.

Identification in Rat Plasma and Urine by Linear Trap Quadrupole-Orbitrap Mass Spectrometry of the Metabolites of Maslinic Acid, a Triterpene from Olives.

PubMed

Sánchez-González, Marta; Lozano-Mena, Glòria; Parra, Andrés; Juan, M Emília; Planas, Joana M

2015-02-04

Maslinic acid is a natural pentacyclic triterpenoid widely distributed in edible and medicinal plants with health-promoting activities. The identification and quantification of its metabolites is a requirement for a better understanding of the biological effects of this triterpene. Therefore, maslinic acid was orally administered to Sprague-Dawley rats at a dose of 50 mg/kg of body weight. Blood and urine were withdrawn at 45 min. Samples were extracted with ethyl acetate prior to liquid chromatography-atmospheric pressure chemical ionization-linear trap quadrupole-Orbitrap (LC-APCI-LTQ-Orbitrap) analysis. Screening of plasma yielded four monohydroxylated derivatives (M1-M4), one monohydroxylated and dehydrogenated metabolite (M5), and two dihydroxylated and dehydrogenated compounds (M6 and M7). In urine, M1, M4, M5, and M6 were detected. Quantification by LC-APCI-mass spectrometry (MS) revealed maslinic acid as the prevalent compound in both plasma (81.8%) and urine (73.9%), which indicates that metabolism is low and mainly attributable to phase I reactions.

Gyroscopic effect in low-energy classical capture of a rotating quadrupolar diatom by an ion.

PubMed

Dashevskaya, Elena; Litvin, Iliya; Nikitin, Evgueni

2006-03-09

The low-energy capture of homonuclear diatoms by ions is due mainly to the long-range part of the interpartner potential with leading terms that correspond to charge-quadrupole interaction and charge-induced dipole interaction. The capture dynamics is described by the perturbed-rotor adiabatic potentials and the Coriolis interaction between manifold of states that belong to a given value of the intrinsic angular momentum. When the latter is large enough, it can noticeably affect the capture cross section calculated in the adiabatic channel approximation due to the gyroscopic property of a rotating diatom. This paper presents the low-energy (low-temperature) state-selected partial and mean capture cross sections (rate coefficients) for the charge-quadrupole interaction that include the gyroscopic effect (decoupling of intrinsic angular momentum from the collision axis), quantum correction for the diatom rotation, and the correction for the charge-induced dipole interaction. These results complement recent studies on the gyroscopic effect in the quantum regime of diatom-ion capture (Dashevskaya, E. I.; Litvin, I.; Nikitin, E. E.; Troe, J. J. Chem. Phys. 2004, 120, 9989-9997).

Production and installation of the LHC low-beta triplets

DOE Office of Scientific and Technical Information (OSTI.GOV)

Feher, S.; Bossert, R.; DiMarco, J.

2005-09-01

The LHC performance depends critically on the low-{beta}, triplets, located on either side of the four interaction points. Each triplet consists of four superconducting quadrupole magnets, which must operate reliably at up to 215 T/m, sustain extremely high heat loads and have an excellent field quality. A collaboration of CERN, Fermilab and KEK was formed in 1996 to design and build the triplet systems, and after nine years of joint effort the production has been completed in 2005. We retrace the main events of the project and present the design features and performance of the low-{beta} quadrupoles, built by KEKmore » and Fermilab, as well as of other vital elements of the triplet. The tunnel installation of the first triplet and plans for commissioning in the LHC are also presented. Apart from the excellent technical results, the construction of the LHC low-{beta} triplets has been a highly enriching experience combining harmoniously the different competences and approaches to engineering in a style reminiscent of high energy physics experiment collaborations, and rarely before achieved in construction of an accelerator.« less

Energy levels, lifetimes, and transition rates for the selenium isoelectronic sequence Pd XIII-Te XIX, Xe XXI-Nd XXVII, W XLI

NASA Astrophysics Data System (ADS)

Wang, K.; Yang, X.; Chen, Z. B.; Si, R.; Chen, C. Y.; Yan, J.; Zhao, X. H.; Dang, W.

2017-09-01

Energy levels, wavelengths, lifetimes, oscillator strengths, and electric dipole (E1), magnetic dipole (M1), electric quadrupole (E2), magnetic quadrupole (M2) transition rates among the 46 fine structure levels belonging to the ([ Ar ] 3d10) 4s2 4p4, ([ Ar ] 3d10) 4s2 4p3 4 d, and ([ Ar ] 3d10) 4 s 4p5 configurations for the selenium isoelectronic sequence Pd XIII-Te XIX, Xe XXI-Nd XXVII, W XLI are reported. These data are determined in the multi-configuration Dirac-Fock (MCDF) approach, in which relativistic effects, main electron correlations within the n = 7 complex, Breit interaction (BI), and quantum electrodynamic (QED) corrections are included. The many-body perturbation theory (MBPT) method is also employed as an independent calculation to confirm the present accuracy, taking W XLI as an example. Comparisons and analysis are made between the present results and available experimental and theoretical ones, and good agreements are obtained. These accurate data are expected to be useful in nuclear fusion research and astrophysical applications.

Modification of the short straight sections of the high energy booster of the SSC

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, M.; Johnson, D.; Kocur, P.

1993-05-01

The tracking analysis with the High Energy Booster (HEB) of the Superconducting Super Collider (SSC) indicated that the machine dynamic aperture for the current lattice (Rev 0 lattice) was limited by the quadrupoles in the short straight sections. A new lattice, Rev 1, with modified short straight sections was proposed. The results of tracking the two lattices up to 5 [times] 10[sup 5] turns (20 seconds at the injection energy) with various random seeds are presented in this paper. The new lattice has increased dynamic aperture from [approximately]7 mm to [approximately]8 mm, increases the abort kicker effectiveness, and eliminates onemore » family (length) of main quadrupoles. The code DIMAD was used for matching the new short straight sections to the ring. The code TEAPOT was used for the short term tracking and to create a machine file, zfile, which could in turn be used to generate a one-turn map with the ZLIB for fast long-term tracking using a symplectic one-turn map tracking program ZIMAPTRK.« less

Modification of the short straight sections of the high energy booster of the SSC

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, M.; Johnson, D.; Kocur, P.

1993-05-01

The tracking analysis with the High Energy Booster (HEB) of the Superconducting Super Collider (SSC) indicated that the machine dynamic aperture for the current lattice (Rev 0 lattice) was limited by the quadrupoles in the short straight sections. A new lattice, Rev 1, with modified short straight sections was proposed. The results of tracking the two lattices up to 5 {times} 10{sup 5} turns (20 seconds at the injection energy) with various random seeds are presented in this paper. The new lattice has increased dynamic aperture from {approximately}7 mm to {approximately}8 mm, increases the abort kicker effectiveness, and eliminates onemore » family (length) of main quadrupoles. The code DIMAD was used for matching the new short straight sections to the ring. The code TEAPOT was used for the short term tracking and to create a machine file, zfile, which could in turn be used to generate a one-turn map with the ZLIB for fast long-term tracking using a symplectic one-turn map tracking program ZIMAPTRK.« less

Isoscalar neutron-proton pairing and SU(4)-symmetry breaking in Gamow-Teller transitions

NASA Astrophysics Data System (ADS)

Kaneko, K.; Sun, Y.; Mizusaki, T.

2018-05-01

The isoscalar neutron-proton pairing is thought to be important for nuclei with equal number of protons and neutrons but its manifestation in structure properties remains to be understood. We investigate the Gamow-Teller (GT) transitions for the f7 /2-shell nuclei in large-scale shell-model calculations with the realistic Hamiltonian. We show that the isoscalar T =0 ,Jπ=1+ neutron-proton pairing interaction plays a decisive role for the concentration of GT strengths at the first-excited 11+ state in 42Sc, and that the suppression of these strengths in 46V, 50Mn, and 54Co is mainly caused by the spin-orbit force supplemented by the quadrupole-quadrupole interaction. Based on the good reproduction of the charge-exchange reaction data, we further analyze the interplay between the isoscalar and isovector pairing correlations. We conclude that even for the most promising A =42 nuclei where the SU(4) isoscalar-isovector-pairing symmetry is less broken, the probability of forming an isoscalar neutron-proton pairing condensation is less than 60% as compared to the expectation at the SU(4)-symmetry limit.

Ultrasonic influence on evolution of disordered dislocation structures

NASA Astrophysics Data System (ADS)

Bachurin, D. V.; Murzaev, R. T.; Nazarov, A. A.

2017-12-01

Evolution of disordered dislocation structures under ultrasonic influence is studied in a model two-dimensional grain within the discrete-dislocation approach. Non-equilibrium grain boundary state is mimicked by a mesodefect located at the corners of the grain, stress field of which is described by that of a wedge junction disclination quadrupole. Significant rearrangement related to gliding of lattice dislocations towards the grain boundaries is found, which results in a noticeable reduction of internal stress fields and cancel of disclination quadrupole. The process of dislocation structure evolution passes through two stages: rapid and slow. The main dislocation rearrangement occurs during the first stage. Reduction of internal stress fields is associated with the number of dislocations entered into the grain boundaries. The change of misorientation angle due to lattice dislocations absorbed by the grain boundaries is evaluated. Amplitude of ultrasonic treatment significantly influences the relaxation of dislocation structure. Preliminary elastic relaxation of dislocation structure does not affect substantially the results of the following ultrasonic treatment. Substantial grain size dependence of relaxation of disordered dislocation systems is found. Simulation results are consistent with experimental data.

Mechanical Design of the LHC Standard Half-Cell

NASA Astrophysics Data System (ADS)

Poncet, A.; Brunet, J. C.; Cruikshank, P.; Genet, M.; Parma, V.; Rohmig, P.; Saban, R.; Tavian, L.; Veness, R.; Vlogaert, J.; Williams, L. R.

1997-05-01

The LHC Conceptual Design Report issued on 20th October 1995 (CERN/AC/95-05 (LHC) - nicknamed "Yellow Book") introduced significant changes to some fundamental features of the LHC standard half-cell, composed of one quadrupole, 3 dipoles and a set of corrector magnets. A separate cryogenic distribution line was introduced, which was previously inside the main cryostat. The dipole length has been increased from 10 to 15 m and independent powering of the focusing and defocusing quadrupole magnets was chosen. Individual quench protection diodes were introduced in magnets interconnects and many auxiliary bus bars were added to feed in series the various families of correcting superconducting magnets. The various highly intricate basic systems such as: cryostats and cryogenics feeders, superconducting magnets and their electrical feeding and protection, vacuum beam screen and its cooling, support and alignment devices have been redesigned, taking into account the very tight space available. These space constraints are given by the necessity to have maximum integral bending field strength for maximum LHC energy, and the existing LHC tunnel. Finally, cryogenic and vacuum sectorisation have been introduced to reduce downtimes and facilitate commissioning.

Characterization of isochlorogenic acid A metabolites in rats using high-performance liquid chromatography/quadrupole time-of-flight mass spectrometry.

PubMed

Wang, Jing; Cao, Guoxiu; Wang, Hong; Ye, Hui; Zhong, Yunxi; Wang, Guangji; Hao, Haiping

2017-08-01

Isochlorogenic acid A is widely present in fruits, vegetables and herbal medicines, and is characterized by anti-inflammatory, hepatoprotective and antiviral properties. However, little is known about its metabolic fate and pharmacokinetic properties. This study is thus designed to investigate the metabolic fate of isochlorogenic acid A. An analytical method based on high-performance liquid chromatography/quadrupole time-of-flight mass spectrometry (HPLC/Q-TOF MS) was established to characterize the metabolites of isochlorogenic acid A in the plasma, urine and feces of rats. A total of 32 metabolites were identified. The metabolic pathways mainly include hydrolyzation, dehydroxylation, hydrogenation and conjugation with methyl, glucuronic acid, glycine, sulfate, glutathione and cysteine. Moreover, the pharmacokinetic profiles of all the circulating metabolites were investigated. M11 resulting from hydrolyzation, dehydroxylation and hydrogenation was the dominant circulating metabolite after the intragastric administration of isochlorogenic acid A. The results obtained will be useful for further study of elucidating potential bioactive metabolites which can provide better explanation of the pharmacological and/or toxicological effects of this compound. Copyright © 2017 John Wiley & Sons, Ltd.

Metabolic Profile of Zearalenone in Liver Microsomes from Different Species and Its in Vivo Metabolism in Rats and Chickens Using Ultra High-Pressure Liquid Chromatography-Quadrupole/Time-of-Flight Mass Spectrometry.

PubMed

Yang, Shupeng; Zhang, Huiyan; Sun, Feifei; De Ruyck, Karl; Zhang, Jinzhen; Jin, Yue; Li, Yanshen; Wang, Zhanhui; Zhang, Suxia; De Saeger, Sarah; Zhou, Jinhui; Li, Yi; De Boevre, Marthe

2017-12-27

To explore differences of zearalenone (ZEN) metabolism between various species, phase I and II metabolism by liver microsomes of animals and human were investigated using ultra high-pressure liquid chromatography-quadrupole/time-of-flight mass spectrometry (UHPLC-Q/TOF MS). A total of 24 metabolites were identified, among which 12 were reported for the first time. Reduction, hydroxylation, and glucuronidation were the major metabolic pathways of ZEN, and significant differences in various species were also observed. Reduction was the main reaction in swine and human, whereas hydroxylation was predominant in rats, chickens, goats, and cows in in vitro systems. Furthemore, in vivo metabolism of ZEN in rats and chickens was investigated, and 23 and 6 metabolites were identified in each species, respectively. Reduction, hydroxylation, and glucuronidation were the major metabolic pathways in rats, while reduction and sulfation predominated in chickens. These results further enrich the biotransformation profile of ZEN, providing a helpful reference for assessing the risks to animals and humans.

Comprehensive Characterization of Extractable and Nonextractable Phenolic Compounds by High-Performance Liquid Chromatography-Electrospray Ionization-Quadrupole Time-of-Flight of a Grape/Pomegranate Pomace Dietary Supplement.

PubMed

Pérez-Ramírez, Iza F; Reynoso-Camacho, Rosalía; Saura-Calixto, Fulgencio; Pérez-Jiménez, Jara

2018-01-24

Grape and pomegranate are rich sources of phenolic compounds, and their derived products could be used as ingredients for the development of functional foods and dietary supplements. However, the profile of nonextractable or macromolecular phenolic compounds in these samples has not been evaluated. Here, we show a comprehensive characterization of extractable and nonextractable phenolic compounds of a grape/pomegranate pomace dietary supplement using high-performance liquid chromatography-electrospray ionization-quadrupole time-of-flight (HPLC-ESI-QTOF) and matrix-assisted laser desorption/ionization (MALDI)-TOF techniques. The main extractable phenolic compounds were several anthocyanins (principally malvidin 3-O-glucoside) as well as gallotannins and gallagyl derivatives; some phenolic compounds were reported in grape or pomegranate for the first time. Additionally, there was a high proportion of nonextractable phenolic compounds, including vanillic acid, and dihydroxybenzoic acid. Unidentified polymeric structures were detected by MALDI-TOF MS analysis. This study shows that mixed grape and pomegranate pomaces are a source of different classes of phenolic compounds including a high proportion of nonextractable phenolic compounds.

Early Cold-Induced Peroxidases and Aquaporins Are Associated With High Cold Tolerance in Dajiao (Musa spp. ‘Dajiao’)

PubMed Central

He, Wei-Di; Gao, Jie; Dou, Tong-Xin; Shao, Xiu-Hong; Bi, Fang-Cheng; Sheng, Ou; Deng, Gui-Ming; Li, Chun-Yu; Hu, Chun-Hua; Liu, Ji-Hong; Zhang, Sheng; Yang, Qiao-Song; Yi, Gan-Jun

2018-01-01

Banana is an important tropical fruit with high economic value. One of the main cultivars (‘Cavendish’) is susceptible to low temperatures, while another closely related specie (‘Dajiao’) has considerably higher cold tolerance. We previously reported that some membrane proteins appear to be involved in the cold tolerance of Dajiao bananas via an antioxidation mechanism. To investigate the early cold stress response of Dajiao, here we applied comparative membrane proteomics analysis for both cold-sensitive Cavendish and cold-tolerant Dajiao bananas subjected to cold stress at 10°C for 0, 3, and 6 h. A total of 2,333 and 1,834 proteins were identified in Cavendish and Dajiao, respectively. Subsequent bioinformatics analyses showed that 692 Cavendish proteins and 524 Dajiao proteins were predicted to be membrane proteins, of which 82 and 137 differentially abundant membrane proteins (DAMPs) were found in Cavendish and Dajiao, respectively. Interestingly, the number of DAMPs with increased abundance following 3 h of cold treatment in Dajiao (80) was seven times more than that in Cavendish (11). Gene ontology molecular function analysis of DAMPs for Cavendish and Dajiao indicated that they belong to eight categories including hydrolase activity, binding, transporter activity, antioxidant activity, etc., but the number in Dajiao is twice that in Cavendish. Strikingly, we found peroxidases (PODs) and aquaporins among the protein groups whose abundance was significantly increased after 3 h of cold treatment in Dajiao. Some of the PODs and aquaporins were verified by reverse-transcription PCR, multiple reaction monitoring, and green fluorescent protein-based subcellular localization analysis, demonstrating that the global membrane proteomics data are reliable. By combining the physiological and biochemical data, we found that membrane-bound Peroxidase 52 and Peroxidase P7, and aquaporins (MaPIP1;1, MaPIP1;2, MaPIP2;4, MaPIP2;6, MaTIP1;3) are mainly involved in decreased lipid peroxidation and maintaining leaf cell water potential, which appear to be the key cellular adaptations contributing to the cold tolerance of Dajiao. This membrane proteomics study provides new insights into cold stress tolerance mechanisms of banana, toward potential applications for ultimate genetic improvement of cold tolerance in banana. PMID:29568304

Energetic ion mass analysis using a radio-frequency quadrupole filter.

PubMed

Medley, S S

1978-06-01

In conventional applications of the radio-frequency quadrupole mass analyzer, the ion injection energy is usually limited to less than the order of 100 eV due to constraints on the dimensions and power supply of the device. However, requirements often arise, for example in fusion plasma ion diagnostics, for mass analysis of much more energetic ions. A technique easily adaptable to any conventional quadrupole analyzer which circumvents the limitation on injection energy is documented in this paper. Briefly, a retarding potential applied to the pole assembly is shown to facilitate mass analysis of multikiloelectron volt ions without altering the salient characteristics of either the quadrupole filter or the ion beam.

Collision induced broadening and shifting of the H and K lines of Ca+ at low temperature

NASA Astrophysics Data System (ADS)

Wang, Xin; Zhang, Rui; Shen, Yong; Liu, Qu; Zou, Hongxin; Yan, Bing

2017-09-01

Multireference configuration interaction method was used to compute the potential energy curves of Λ-S states correlating with lowest three atomic limits in Ca+-He molecular collision system. The potential energy curves of nine Ω states were obtained with inclusion of spin-orbit coupling. And the electric dipole and quadrupole moment matrix elements between excited states and ground state were also computed. Furthermore, with aid of the Anderson-Talman theory we calculated the broadening and shifting coefficients for Ca+-He spectral lines in the low temperature regime. For H line, α = 0.303 × 10-20 cm-1/cm-3, β = -0.0527 × 10-20cm-1/cm-3; For K line, α = 0.233 × 10-20cm-1/cm-3, β = -0.0402 × 10-20cm-1/cm-3 These results are helpful to understand the collision effects induced by He atom in further spectra investigations of cold Ca+ ions.

Determination of contamination character of materials in space technology testing

NASA Technical Reports Server (NTRS)

Haynes, D. L.; Coulson, D. M.

1972-01-01

The contamination character of selected materials used in space technology testing is presented. Many of these materials contain components that become volatile in a space environment. Most previous data were limited to weight loss or vapor pressure. However, these parameters are not necessarily a direct measure of the contamination character of these materials. Selected materials were exposed to a thermal-vacuum environment, and the degree of contamination was measured by collecting the outgases from these materials on a cold test mirror surface. The degradation of reflectivity of the mirror was measured over a spectral range from 1100 A to 2.5 microns. Half the mirror's surface was also exposed to UV irradiation to determine its effects on the contaminative character of the depositing outgases. The amount of deposit per unit area was measured by microbalances mounted near the mirror; the sensor of one microbalance was UV irradiated. A quadrupole mass spectrometer was used to determine the composition of the outgases.

Isolation of Ion-Driven Conformations in Diphenylacetylene Molecular Switches Using Cryogenic Infrared Spectroscopy

NASA Astrophysics Data System (ADS)

Wolk, Arron B.; Garand, Etienne; Jones, Ian M.; Kamrath, Michael Z.; Hamilton, Rew; Johnson, Mark A.

2012-06-01

We report the infrared predissociation spectra of a family of ionic diphenylacetylene molecular switch complexes. The electrosprayed complexes were trapped and cooled in a cryogenic (10K) quadrupole ion trap and tagged with molecular deuterium. The infrared spectra of the vibrationally cold species reveal sharp transitions over a wide energy range (800 - 3800 cm-1), facilitating comparison to harmonic spectra. The evolution of the band pattern upon derivatization of the complexes exposes the signatures of the amide, urea, and carbonyl functionalities, enabling unambiguous identification of the non-covalent interactions that control the secondary structure of the molecule. Complexation with the tetramethylammonium cation reveals a conformation analogous to that of the neutral molecule, while halide ion attachment induces a conformational change similar to that observed earlier in solution. In several cases, both the donor and acceptor groups involved in the multidentate H-bonds are observed, providing a microscopic mechanical picture of the interactions at play. I. Jones, and A. Hamilton, Angew. Chem. Intl. Edit. 50, 4597 (2011).

Progress toward studies of bubble-geometry Bose-Einstein condensates in microgravity with a ground-based prototype of NASA CAL

NASA Astrophysics Data System (ADS)

Lundblad, Nathan; Jarvis, Thomas; Paseltiner, Daniel; Lannert, Courtney

2016-05-01

We have proposed using NASA's Cold Atom Laboratory (CAL, launching to the International Space Station in 2017) to generate bubble-geometry Bose-Einstein condensates through radiofrequency dressing of an atom-chip magnetic trap. This geometry has not been truly realized terrestrially due to the perturbing influence of gravity, making it an ideal candidate for microgravity investigation aboard CAL. We report progress in the construction of a functional prototype of the orbital BEC apparatus: a compact atom-chip machine loaded by a 2D+MOT source, conventional 3D MOT, quadrupole trap, and transfer coil. We also present preliminary modeling of the dressed trap uniformity, which will crucially inform the geometric closure of the BEC shell surface as atom number, bubble radius, and bubble aspect ratio are varied. Finally, we discuss plans for experimental sequences to be run aboard CAL guided by intuition from ground-based prototype operation. JPL 1502172.

Lunar mass spectrometer test program

NASA Technical Reports Server (NTRS)

Torney, F. L.; Dobrott, J. R.

1972-01-01

The procedures are described along with results obtained in a test program conducted to demonstrate the performance of a candidate lunar mass spectrometer. The instrument was designed to sample and measure gases believed to exist in the lunar atmosphere at the surface. The subject instrument consists of a cold cathode ion source, a small quadrupole mass analyzer and an off axis electron multiplier ion counting detector. The major program emphasis was placed on demonstrating instrument resolution, sensitivity and S/N ratio over the mass range 0-150 amu and over a partial pressure range from 10 to the minus 9th power to 10 to the minus 13th power torr. Ultrahigh vacuum tests were conducted and the minimum detectable partial pressure for neon, argon, krypton and xenon was successfully determined for the spectrometer using isotopes of these gases. With the exception of neon, the minimum detectable partial pressure is approximately 4 x 10 to the minus 14th power torr for the above gases.

Theory of electronic structures and nuclear quadrupole interactions in molecular solids and semiconductor surfaces

NASA Astrophysics Data System (ADS)

Pati, Ranjit

We have investigated, using the Hartree-Fock Roothaan variational procedure, the electronic structures and associated nuclear quadrupole interactions (NQI) for the molecular solids, RDX (C3H6N6O6),/ /beta- HMX(C4H8N8O8), Cocaine (C17H21NO4), Cocaine Hydrochloride (C17H21NO4HCl) and Heroin (C21H23NO5) and for the (111) surface of silicon with adsorbed radioactive 111In atom and negative cadmium ion containing the excited nucleus 111Cd/* resulting from electron capture by lllIn. Our investigations indicate that for the ring 14N NQI parameters in RDX and β-HMX there is very good agreement between theory and experiment. For the peripheral 14N nuclei in NO2 groups, while the calculated electronic structures do explain the much weaker quadrupole coupling constants for these nuclei relative to the ring 14N nuclei, there are significant differences between theory and experiment. The influence of intermolecular interactions between adjacent molecules in the solid is invoked as a possible source for these differences. For the controlled substances, Cocaine and Heroin, again very good agreement is obtained between theory and experiment. For Cocaine Hydrochloride theory is able to explain the much smaller observed 14N nuclear quadrupole resonance frequency as compared to pure Cocaine. However there are significant differences between theory and experiment for the 14N and 35Cl quadrupole resonance frequencies. The influence of intermolecular interactions is one of the factors suggested to explain the difference. For the silicon (111) surface, the observed 111Cd/* NQI parameters, with the cadmium nucleus assumed to be located at the same site as the 111In nucleus from which it is generated, can be successfully explained by theory with the indium atom located at the two distinct sites available with the DAS model for the 7 x 7 reconstructed (111) surface. Some quantitative differences still remain, one of the main factor suggested for their explanation being a need for a thorough analysis of relaxation effects in the positions of silicon atoms associated with the presence of the indium atom. Applications of the Hartree-Fock Cluster theory to other related systems is suggested to subject the DAS model to additional tests at the microscopic level as in the system studied in the present thesis. (Abstract shortened by UMI.)

Introduction: the human sciences and Cold War America.

PubMed

Isaac, Joel

2011-01-01

Studies of the history of the human sciences during the Cold War era have proliferated over the past decade--in JHBS and elsewhere. This special issue focuses on the connections between the behavioral sciences and the culture and politics of the Cold War in the United States. In the recent literature, there is a tendency to identify the Cold War human sciences with two main paradigms: that of psychocultural analysis, on the one hand, and of the systems sciences, on the other. The essays in the special issue both extend understanding of each of these interpretive frameworks and help us to grasp their interconnection. © 2011 Wiley Periodicals, Inc.

The Planck Catalogue of Galactic Cold Clumps : PGCC

NASA Astrophysics Data System (ADS)

Montier, L.

The Planck satellite has provided an unprecedented view of the submm sky, allowing us to search for the dust emission of Galactic cold sources. Combining Planck-HFI all-sky maps in the high frequency channels with the IRAS map at 100um, we built the Planck catalogue of Galactic Cold Clumps (PGCC, Planck 2015 results. XXVIII), counting 13188 sources distributed over the whole sky, and following mainly the Galactic structures at low and intermediate latitudes. This is the first all-sky catalogue of Galactic cold sources obtained with a single instrument at this resolution and sensitivity, which opens a new window on star-formation processes in our Galaxy.

Local correction of quadrupole errors at LHC interaction regions using action and phase jump analysis on turn-by-turn beam position data

NASA Astrophysics Data System (ADS)

Cardona, Javier Fernando; García Bonilla, Alba Carolina; Tomás García, Rogelio

2017-11-01

This article shows that the effect of all quadrupole errors present in an interaction region with low β * can be modeled by an equivalent magnetic kick, which can be estimated from action and phase jumps found on beam position data. This equivalent kick is used to find the strengths that certain normal and skew quadrupoles located on the IR must have to make an effective correction in that region. Additionally, averaging techniques to reduce noise on beam position data, which allows precise estimates of equivalent kicks, are presented and mathematically justified. The complete procedure is tested with simulated data obtained from madx and 2015-LHC experimental data. The analyses performed in the experimental data indicate that the strengths of the IR skew quadrupole correctors and normal quadrupole correctors can be estimated within a 10% uncertainty. Finally, the effect of IR corrections in the β* is studied, and a correction scheme that returns this parameter to its designed value is proposed.

An energy-filtering device coupled to a quadrupole mass spectrometer for soft-landing molecular ions on surfaces with controlled energy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bodin, A.; Laloo, R.; Abeilhou, P.

2013-09-15

We have developed an energy-filtering device coupled to a quadrupole mass spectrometer to deposit ionized molecules on surfaces with controlled energy in ultra high vacuum environment. Extensive numerical simulations as well as direct measurements show that the ion beam flying out of a quadrupole exhibits a high-energy tail decreasing slowly up to several hundred eV. This energy distribution renders impossible any direct soft-landing deposition of molecular ions. To remove this high-energy tail by energy filtering, a 127° electrostatic sector and a specific triplet lenses were designed and added after the last quadrupole of a triple quadrupole mass spectrometer. The resultsmore » obtained with this energy-filtering device show clearly the elimination of the high-energy tail. The ion beam that impinges on the sample surface satisfies now the soft-landing criterion for molecular ions, opening new research opportunities in the numerous scientific domains involving charges adsorbed on insulating surfaces.« less

Evaluating Mass Analyzers as Candidates for Small, Portable, Rugged Single Point Mass Spectrometers for Analysis of Permanent Gases

NASA Technical Reports Server (NTRS)

Arkin, C. Richard; Ottens, Andrew K.; Diaz, Jorge A.; Griffin, Timothy P.; Follestein, Duke; Adams, Fredrick; Steinrock, T. (Technical Monitor)

2001-01-01

For Space Shuttle launch safety, there is a need to monitor the concentration Of H2, He, O2, and Ar around the launch vehicle. Currently a large mass spectrometry system performs this task, using long transport lines to draw in samples. There is great interest in replacing this stationary system with several miniature, portable, rugged mass spectrometers which act as point sensors which can be placed at the sampling point. Five commercial and two non-commercial analyzers are evaluated. The five commercial systems include the Leybold Inficon XPR-2 linear quadrupole, the Stanford Research (SRS-100) linear quadrupole, the Ferran linear quadrupole array, the ThermoQuest Polaris-Q quadrupole ion trap, and the IonWerks Time-of-Flight (TOF). The non-commercial systems include a compact double focusing sector (CDFMS) developed at the University of Minnesota, and a quadrupole ion trap (UF-IT) developed at the University of Florida.

Triple Quadrupole Versus High Resolution Quadrupole-Time-of-Flight Mass Spectrometry for Quantitative LC-MS/MS Analysis of 25-Hydroxyvitamin D in Human Serum

NASA Astrophysics Data System (ADS)

Geib, Timon; Sleno, Lekha; Hall, Rabea A.; Stokes, Caroline S.; Volmer, Dietrich A.

2016-08-01

We describe a systematic comparison of high and low resolution LC-MS/MS assays for quantification of 25-hydroxyvitamin D3 in human serum. Identical sample preparation, chromatography separations, electrospray ionization sources, precursor ion selection, and ion activation were used; the two assays differed only in the implemented final mass analyzer stage; viz. high resolution quadrupole-quadrupole-time-of-flight (QqTOF) versus low resolution triple quadrupole instruments. The results were assessed against measured concentration levels from a routine clinical chemiluminescence immunoassay. Isobaric interferences prevented the simple use of TOF-MS spectra for extraction of accurate masses and necessitated the application of collision-induced dissociation on the QqTOF platform. The two mass spectrometry assays provided very similar analytical figures of merit, reflecting the lack of relevant isobaric interferences in the MS/MS domain, and were successfully applied to determine the levels of 25-hydroxyvitamin D for patients with chronic liver disease.

Performance of the first short model 150 mm aperture Nb$$_3$$Sn Quadrupole MQXFS for the High- Luminosity LHC upgrade

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chlachidze, G.; et al.

2016-08-30

The US LHC Accelerator Research Program (LARP) and CERN combined their efforts in developing Nb3Sn magnets for the High-Luminosity LHC upgrade. The ultimate goal of this collaboration is to fabricate large aperture Nb3Sn quadrupoles for the LHC interaction regions (IR). These magnets will replace the present 70 mm aperture NbTi quadrupole triplets for expected increase of the LHC peak luminosity by a factor of 5. Over the past decade LARP successfully fabricated and tested short and long models of 90 mm and 120 mm aperture Nb3Sn quadrupoles. Recently the first short model of 150 mm diameter quadrupole MQXFS was builtmore » with coils fabricated both by the LARP and CERN. The magnet performance was tested at Fermilab’s vertical magnet test facility. This paper reports the test results, including the quench training at 1.9 K, ramp rate and temperature dependence studies.« less

Protective coatings of metal surfaces by cold plasma treatment

NASA Technical Reports Server (NTRS)

Manory, R.; Grill, A.

1985-01-01

The cold plasma techniques for deposition of various types of protective coatings are reviewed. The main advantage of these techniques for deposition of ceramic films is the lower process temperature, which enables heat treating of the metal prior to deposition. In the field of surface hardening of steel, significant reduction of treatment time and energy consumption were obtained. A simple model for the plasma - surface reactions in a cold plasma system is presented, and the plasma deposition techniques are discussed in view of this model.

CFD Modelling of a Quadrupole Vortex Inside a Cylindrical Channel for Research into Advanced Hybrid Rocket Designs

NASA Astrophysics Data System (ADS)

Godfrey, B.; Majdalani, J.

2014-11-01

This study relies on computational fluid dynamics (CFD) tools to analyse a possible method for creating a stable quadrupole vortex within a simulated, circular-port, cylindrical rocket chamber. A model of the vortex generator is created in a SolidWorks CAD program and then the grid is generated using the Pointwise mesh generation software. The non-reactive flowfield is simulated using an open source computational program, Stanford University Unstructured (SU2). Subsequent analysis and visualization are performed using ParaView. The vortex generation approach that we employ consists of four tangentially injected monopole vortex generators that are arranged symmetrically with respect to the center of the chamber in such a way to produce a quadrupole vortex with a common downwash. The present investigation focuses on characterizing the flow dynamics so that future investigations can be undertaken with increasing levels of complexity. Our CFD simulations help to elucidate the onset of vortex filaments within the monopole tubes, and the evolution of quadrupole vortices downstream of the injection faceplate. Our results indicate that the quadrupole vortices produced using the present injection pattern can become quickly unstable to the extent of dissipating soon after being introduced into simulated rocket chamber. We conclude that a change in the geometrical configuration will be necessary to produce more stable quadrupoles.

1H NMR relaxometry and quadrupole relaxation enhancement as a sensitive probe of dynamical properties of solids—[C(NH2)3]3Bi2I9 as an example

NASA Astrophysics Data System (ADS)

Florek-Wojciechowska, M.; Wojciechowski, M.; Jakubas, R.; Brym, Sz.; Kruk, D.

2016-02-01

1H nuclear magnetic resonance relaxometry has been applied to reveal information on dynamics and structure of Gu3Bi2I9 ([Gu = C(NH2)3] denotes guanidinium cation). The data have been analyzed in terms of a theory of quadrupole relaxation enhancement, which has been extended here by including effects associated with quadrupole (14N) spin relaxation caused by a fast fluctuating component of the electric field gradient tensor. Two motional processes have been identified: a slow one occurring on a timescale of about 8 × 10-6 s which has turned out to be (almost) temperature independent, and a fast process in the range of 10-9 s. From the 1H-14N relaxation contribution (that shows "quadrupole peaks") the quadrupole parameters, which are a fingerprint of the arrangement of the anionic network, have been determined. It has been demonstrated that the magnitude of the quadrupole coupling considerably changes with temperature and the changes are not caused by phase transitions. At the same time, it has been shown that there is no evidence of abrupt changes in the cationic dynamics and the anionic substructure upon the phase transitions.

Analysis of twenty five impurities in uranium matrix by ICP-MS with iron measurement optimized by using reaction collision cell, cold plasma or medium resolution.

PubMed

Quemet, Alexandre; Brennetot, Rene; Chevalier, Emilie; Prian, Edwina; Laridon, Anne-Laure; Mariet, Clarisse; Fichet, Pascal; Laszak, Ivan; Goutelard, Florence

2012-09-15

An analytical procedure was developed to determine the concentration of 25 impurities (Li, Be, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, Zr, Mo, Ag, Cd, In, Sm, Eu, Gd, Dy, W, Pb, Bi and Th) in a uranium matrix using the quadrupole inductively coupled plasma mass spectrometry (Q-ICP-MS). The dissolution of U(3)O(8) powder was made with a mixture of hydrochloric acid and nitric acid. Then, a selective separation of uranium using the UTEVA column was used before measurement by Q-ICP-MS. The procedure developed was verified using the Certified Reference Material "Morille". The analytical results agree well except for 5 elements where values are underestimated (Li, Be, In, Pb and Bi). Among the list of impurities, iron was particularly investigated because it is well known that this element possesses a polyatomic interference that increases the detection limit. A comparison between iron detection limits obtained with different methods was performed. Iron polyatomic interference was at least reduced, or at best entirely resolved in some cases, by using the cold plasma or the collision/reaction cell with several gases (He, NH(3) and CH(4)). High-resolution ICP-MS was used to compare the results obtained. A detection limit as low as 8 ng L(-1) was achieved. Copyright © 2012 Elsevier B.V. All rights reserved.

Genetic and epigenetic stability of cryopreserved and cold-stored hops (Humulus lupulus L.).

PubMed

Peredo, Elena L; Arroyo-García, Rosa; Reed, Barbara M; Revilla, M Angeles

2008-12-01

Conventional cold storage and cryopreservation methods for hops (Humulus lupulus L.) are available but, to our knowledge, the genetic and epigenetic stability of the recovered plants have not been tested. This study analyzed 51 accessions of hop using the molecular techniques, Random Amplified DNA Polymorphism (RAPD) and Amplified Fragment Length Polymorphism (AFLP), revealing no genetic variation among greenhouse-grown controls and cold stored or cryopreserved plants. Epigenetic stability was evaluated using Methylation Sensitive Amplified Polymorphism (MSAP). Over 36% of the loci were polymorphic when the cold and cryo-treated plants were compared to greenhouse plants. The main changes were demethylation events and they were common to the cryopreserved and cold stored plants indicating the possible effect of the in vitro establishment process, an essential step in both protocols. Protocol-specific methylation patterns were also detected indicating that both methods produced epigenetic changes in plants following cold storage and cryopreservation.

Mass resolution of linear quadrupole ion traps with round rods.

PubMed

Douglas, D J; Konenkov, N V

2014-11-15

Auxiliary dipole excitation is widely used to eject ions from linear radio-frequency quadrupole ion traps for mass analysis. Linear quadrupoles are often constructed with round rod electrodes. The higher multipoles introduced to the electric potential by round rods might be expected to change the ion ejection process. We have therefore investigated the optimum ratio of rod radius, r, to field radius, r0, for excitation and ejection of ions. Trajectory calculations are used to determine the excitation contour, S(q), the fraction of ions ejected when trapped at q values close to the ejection (or excitation) q. Initial conditions are randomly selected from Gaussian distributions of the x and y coordinates and a thermal distribution of velocities. The N = 6 (12 pole) and N = 10 (20 pole) multipoles are added to the quadrupole potential. Peak shapes and resolution were calculated for ratios r/r0 from 1.09 to 1.20 with an excitation time of 1000 cycles of the trapping radio-frequency. Ratios r/r0 in the range 1.140 to 1.160 give the highest resolution and peaks with little tailing. Ratios outside this range give lower resolution and peaks with tails on either the low-mass side or the high-mass side of the peaks. This contrasts with the optimum ratio of 1.126-1.130 for a quadrupole mass filter operated conventionally at the tip of the first stability region. With the optimum geometry the resolution is 2.7 times greater than with an ideal quadrupole field. Adding only a 2.0% hexapole field to a quadrupole field increases the resolution by a factor of 1.6 compared with an ideal quadrupole field. Addition of a 2.0% octopole lowers resolution and degrades peak shape. With the optimum value of r/r0 , the resolution increases with the ejection time (measured in cycles of the trapping rf, n) approximately as R0.5 = 6.64n, in contrast to a pure quadrupole field where R0.5 = 1.94n. Adding weak nonlinear fields to a quadrupole field can improve the resolution with mass-selective ejection of ions by up to a factor of 2.7. The optimum ratio r/r0 is 1.14 to 1.16, which differs from the optimum ratio for a mass filter of 1.128-1.130. Copyright © 2014 John Wiley & Sons, Ltd.

Site-specific N-glycosylation analysis: matrix-assisted laser desorption/ionization quadrupole-quadrupole time-of-flight tandem mass spectral signatures for recognition and identification of glycopeptides.

PubMed

Krokhin, Oleg; Ens, Werner; Standing, Kenneth G; Wilkins, John; Perreault, Hélène

2004-01-01

The identification of glycosylation sites in proteins is often possible through a combination of proteolytic digestion, separation, mass spectrometry (MS) and tandem MS (MS/MS). Liquid chromatography (LC) in combination with MS/MS has been a reliable method for detecting glycopeptides in digestion mixtures, and for assigning glycosylation sites and glycopeptide sequences. Direct interfacing of LC with MS relies on electrospray ionization, which produces ions with two, three or four charges for most proteolytic peptides and glycopeptides. MS/MS spectra of such glycopeptide ions often lead to ambiguous interpretation if deconvolution to the singly charged level is not used. In contrast, the matrix-assisted laser desorption/ionization (MALDI) technique usually produces singly charged peptide and glycopeptide ions. These ions require an extended m/z range, as provided by the quadrupole-quadrupole time-of-flight (QqTOF) instrument used in these experiments, but the main advantages of studying singly charged ions are the simplicity and consistency of the MS/MS spectra. A first aim of the present study is to develop methods to recognize and use glycopeptide [M+H]+ ions as precursors for MS/MS, and thus for glycopeptide/glycoprotein identification as part of wider proteomics studies. Secondly, this article aims at demonstrating the usefulness of MALDI-MS/MS spectra of N-glycopeptides. Mixtures of diverse types of proteins, obtained commercially, were prepared and subjected to reduction, alkylation and tryptic digestion. Micro-column reversed-phase separation allowed deposition of several fractions on MALDI plates, followed by MS and MS/MS analysis of all peptides. Glycopeptide fractions were identified after MS by their specific m/z spacing patterns (162, 203, 291 u) between glycoforms, and then analyzed by MS/MS. In most cases, MS/MS spectra of [M+H]+ ions of glycopeptides featured peaks useful for determining sugar composition, peptide sequence, and thus probable glycosylation site. Peptide-related product ions could be used in database search procedures and allowed the identification of the glycoproteins. Copyright 2004 John Wiley & Sons, Ltd.

Extracerebral deep-body cold sensitivity in the Pekin duck.

PubMed

Inomoto, T; Simon, E

1981-09-01

Pekin ducks, in which cerebral cold sensitivity is negligible, were submitted to general body cooling at warm, thermoneutral, and cold ambient temperature (Ta) with an intestinal thermode. In some animals, hypothermia was enhanced by additional hypothalamic cooling that suppressed cold defense. In other animals, the spinal cord was cooled, either selectively or during intestinal cooling. From core temperature (Tc) and metabolic heat production (M) an overall cold sensitivity of about -5 to -6 W . kg-1 . degrees C-1 was determined at thermoneutrality. Maximum M amounted to four to five times the resting M of 3.8 W . kg-1 and was attained when Tc fell by 2.5 degrees C or more. In the cold, threshold Tc for the activation of M was elevated; overall cold sensitivity remained constant. In the warmth, threshold Tc was lowered; overall cold sensitivity was reduced, if mean skin temperature (Tsk) remained at aout 39 degrees C or higher. Spinal cold sensitivity amounted to about -0.25 W . kg-1 . degrees C-1 at normal Tc and thermoneutral and warm Ta; it increased to aout -0.50 W . kg-1 . degrees C-1 in the cold and during hypothermia. Peripheral cold sensitivity was estimated from Tsk and M as -0.4 to -0.8 W . kg-1 . degrees C-1. It is concluded that overall cold sensitivity in ducks mainly depends on deep-body temperature sensors outside of the central nervous system.

Design and fabrication of a basic mass analyzer and vacuum system

NASA Technical Reports Server (NTRS)

Judson, C. M.; Josias, C.; Lawrence, J. L., Jr.

1977-01-01

A two-inch hyperbolic rod quadrupole mass analyzer with a mass range of 400 to 200 amu and a sensitivity exceeding 100 packs per billion has been developed and tested. This analyzer is the basic hardware portion of a microprocessor-controlled quadrupole mass spectrometer for a Gas Analysis and Detection System (GADS). The development and testing of the hyperbolic-rod quadrupole mass spectrometer and associated hardware are described in detail.

Stability of an aqueous quadrupole micro-trap

DOE PAGES

Park, Jae Hyun; Krstić, Predrag S.

2012-03-30

Recently demonstrated functionality of an aqueous quadrupole micro- or nano-trap opens a new avenue for applications of the Paul traps, like is confinement of a charged biomolecule which requires water environment for its chemical stability. Besides strong viscosity forces, motion of a charged particle in the aqueous trap is subject to dielectrophoretic and electrophoretic forces. In this study, we describe the general conditions for stability of a charged particle in an aqueous quadrupole trap. We find that for the typical micro-trap parameters, effects of both dielectrophoresis and electrophoresis significantly influence the trap stability. In particular, the aqueous quadrupole trap couldmore » play of a role of a synthetic virtual nanopore for the 3rd generation of DNA sequencing technology.« less

First Test Results of the 150 mm Aperture IR Quadrupole Models for the High Luminosity LHC

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ambrosio, G.; Chlachidze, G.; Wanderer, P.

2016-10-06

The High Luminosity upgrade of the LHC at CERN will use large aperture (150 mm) quadrupole magnets to focus the beams at the interaction points. The high field in the coils requires Nb3Sn superconductor technology, which has been brought to maturity by the LHC Accelerator Re-search Program (LARP) over the last 10 years. The key design targets for the new IR quadrupoles were established in 2012, and fabrication of model magnets started in 2014. This paper discusses the results from the first single short coil test and from the first short quadrupole model test. Remaining challenges and plans to addressmore » them are also presented and discussed.« less

Storage and sterilization techniques: the specific role of the cold chain.

PubMed

Guinebault, A

1986-01-01

Focus in this discussion is on reasons for the cold chain, management of vaccine supplies (regional storage, peripheral centers, and the clinic), the facilities and their use, monitoring the cold chain, and training participants in the cold chain. To remain active, vaccines must be maintained continuously within a specific temperature range from the moment they are produced until they are injected. This is the meaning of the cold chain. If the cold chain is broken at any point, the vaccines must be destroyed for they will have lost their effectiveness. To function properly, a cold chain requires the combined presence of efficient, reliable equipment, and of qualified, vigilant personnel at all levels. The cold chain is composed of the following elements: a national storage center, near an international airport, with a 1-year supply of vaccines for the entire target population; regional storage centers with a 3-month supply of vaccines for the entire population of the region; peripheral immunization centers scattered throughout the region, managing a supply for about 1 month; clinics, which either perform vaccinations on the spot and/or supply mobile teams, depending on the strategy; and mobile teams, with portable cold boxes, with an autonomy of several days. The main problems occur at the local levels, and more specifically with respect to transportation and the fuel and power supplies, as well as cold packs. At the central level, the 1-year supply of vaccines generally is stored in cold rooms. Personnel in charge of central strorage also are responsible for transportation to and from these cold rooms. Once the space required for storing vaccines is determined, the facilities required at each level may be evaluated. The information essential to the choice must be considered in each case. The main criteria involved are outlined. There are many devices for monitoring the function of the cold chain: indicators, which accompany the vaccines from the central depot to the peripheral centers show any excesses in temperature and their duration; and devices such as thermometers show the present temperature, independently of the "history" of the vaccine. Some devices are available for checking individual elements of the cold chain from time to time. The World Health Organization (WHO) has developed a training strategy aimed at people on all levels: international consultants and decisionmakers involved in programming the Expanded Program on Immunization; technicians in charge of maintenance; and medical personnel.

Identification and analysis of chemical constituents and rat serum metabolites in Suan-Zao-Ren granule using ultra high performance liquid chromatography quadrupole time-of-flight mass spectrometry combined with multiple data processing approaches.

PubMed

Du, Yiyang; He, Bosai; Li, Qing; He, Jiao; Wang, Di; Bi, Kaishun

2017-07-01

Suan-Zao-Ren granule is widely used to treat insomnia in China. However, because of the complexity and diversity of the chemical compositions in traditional Chinese medicine formula, the comprehensive analysis of constituents in vitro and in vivo is rather difficult. In our study, an ultra high performance liquid chromatography with quadrupole time-of-flight mass spectrometry and the PeakView® software, which uses multiple data processing approaches including product ion filter, neutral loss filter, and mass defect filter, method was developed to characterize the ingredients and rat serum metabolites in Suan-Zao-Ren granule. A total of 101 constituents were detected in vitro. Under the same analysis conditions, 68 constituents were characterized in rat serum, including 35 prototype components and 33 metabolites. The metabolic pathways of main components were also illustrated. Among them, the metabolic pathways of timosaponin AI were firstly revealed. The bioactive compounds mainly underwent the phase I metabolic pathways including hydroxylation, oxidation, hydrolysis, and phase II metabolic pathways including sulfate conjugation, glucuronide conjugation, cysteine conjugation, acetycysteine conjugation, and glutathione conjugation. In conclusion, our results showed that this analysis approach was extremely useful for the in-depth pharmacological research of Suan-Zao-Ren granule and provided a chemical basis for its rational. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Wavelength-dependent UV photodesorption of pure N2 and O2 ices

NASA Astrophysics Data System (ADS)

Fayolle, E. C.; Bertin, M.; Romanzin, C.; Poderoso, H. A. M.; Philippe, L.; Michaut, X.; Jeseck, P.; Linnartz, H.; Öberg, K. I.; Fillion, J.-H.

2013-08-01

Context. Ultraviolet photodesorption of molecules from icy interstellar grains can explain observations of cold gas in regions where thermal desorption is negligible. This non-thermal desorption mechanism should be especially important where UV fluxes are high. Aims: N2 and O2 are expected to play key roles in astrochemical reaction networks, both in the solid state and in the gas phase. Measurements of the wavelength-dependent photodesorption rates of these two infrared-inactive molecules provide astronomical and physical-chemical insights into the conditions required for their photodesorption. Methods: Tunable radiation from the DESIRS beamline at the SOLEIL synchrotron in the astrophysically relevant 7 to 13.6 eV range is used to irradiate pure N2 and O2 thin ice films. Photodesorption of molecules is monitored through quadrupole mass spectrometry. Absolute rates are calculated by using the well-calibrated CO photodesorption rates. Strategic N2 and O2 isotopolog mixtures are used to investigate the importance of dissociation upon irradiation. Results: N2 photodesorption mainly occurs through excitation of the b1Πu state and subsequent desorption of surface molecules. The observed vibronic structure in the N2 photodesorption spectrum, together with the absence of N3 formation, supports that the photodesorption mechanism of N2 is similar to CO, i.e., an indirect DIET (Desorption Induced by Electronic Transition) process without dissociation of the desorbing molecule. In contrast, O2 photodesorption in the 7-13.6 eV range occurs through dissociation and presents no vibrational structure. Conclusions: Photodesorption rates of N2 and O2 integrated over the far-UV field from various star-forming environments are lower than for CO. Rates vary between 10-3 and 10-2 photodesorbed molecules per incoming photon.

Titan's Cold Accretion and its Internal Structure

NASA Astrophysics Data System (ADS)

Estrada, Paul R.; Mosqueira, I.

2010-10-01

Recent Cassini radio tracking data has provided a normalized moment of inertia for Titan of 0.34 (Iess et al. 2010). Given that the quadrupole field is consistent with hydrostatic equilibrium, a two-layer interior model implies incomplete differentiation with a 700 km water-ice shell and an undifferentiated ice and rock-metal interior. We investigate the accretional history of Titan in connection with its internal structure. Our formation model allows for a size distribution of impactors with upper size cut-off constrained by Hyperion's size and a variable power-law exponent (Mosqueira et al. 2010). The burial of impact energy takes place in a lengthscale of order of the impactor radius, as indicated by numerical simulations (e.g., Pierazzo et al. 1997) applied to our energy regime of interest. Our thermal model includes radiogenic heating due to short and long-lived radionuclides, latent heat of melting, gravitational energy release due to sinking rock, heat of accretion and radiative cooling. We find that melting in the interior takes place well before the satellite reaches its final size. As a result, we expect the formation of an ocean overlying a silicate carapace, which may spend a considerable amount of time in contact with the liquid layer. Such a framework not only facilitates the transport of heat from the interior, but also can help both in leaching Ar40 into the ocean and then releasing into the atmosphere. We consider a range of parameters such as the degree of hydration of the rock component, the fraction of the impact energy that is deposited at the surface of the satellite, and accretion times. But we do not yet consider the effects of small admixtures of contaminants. We argue that models that form Titan in a cold environment may have allowed for the interior to remain cold enough as to preclude complete differentiation.

Comparative analysis of the response and gene regulation in cold resistant and susceptible tea plants

PubMed Central

Pan, Cheng; Wang, Yiwei; Kong, Lei; Jiang, Huiguang; Xu, Yiqun; Wang, Wenzhi; Pan, Yuting; Li, Yeyun; Jiang, Changjun

2017-01-01

Cold environment is the main constraint for tea plants (Camellia sinensis) distribution and tea farming. We identified two tea cultivars, called var. sinensis cv. Shuchazao (SCZ) with a high cold-tolerance and var. assamica cv. Yinghong9 (YH9) with low cold-tolerance. To better understand the response mechanism of tea plants under cold stress for improving breeding, we compared physiological and biochemical responses, and associated genes expression in response to 7-day and 14-day cold acclimation, followed by 7-day de-acclimation in these two tea cultivars. We found that the low EL50, low Fv/Fm, and high sucrose and raffinose accumulation are responsible for higher cold tolerance in SCZ comparing with YH9. We then measured the expression of 14 key homologous genes, known as involved in these responses in other plants, for each stages of treatment in both cultivars using RT-qPCR. Our results suggested that the increased expression of CsCBF1 and CsDHNs coupling with the accumulation of sucrose play key roles in conferring higher cold resistance in SCZ. Our findings have revealed key genes regulation responsible for cold resistance, which help to understand the cold-resistant mechanisms and guide breeding in tea plants. PMID:29211766

Comparative analysis of the response and gene regulation in cold resistant and susceptible tea plants.

PubMed

Ban, Qiuyan; Wang, Xuewen; Pan, Cheng; Wang, Yiwei; Kong, Lei; Jiang, Huiguang; Xu, Yiqun; Wang, Wenzhi; Pan, Yuting; Li, Yeyun; Jiang, Changjun

2017-01-01

Cold environment is the main constraint for tea plants (Camellia sinensis) distribution and tea farming. We identified two tea cultivars, called var. sinensis cv. Shuchazao (SCZ) with a high cold-tolerance and var. assamica cv. Yinghong9 (YH9) with low cold-tolerance. To better understand the response mechanism of tea plants under cold stress for improving breeding, we compared physiological and biochemical responses, and associated genes expression in response to 7-day and 14-day cold acclimation, followed by 7-day de-acclimation in these two tea cultivars. We found that the low EL50, low Fv/Fm, and high sucrose and raffinose accumulation are responsible for higher cold tolerance in SCZ comparing with YH9. We then measured the expression of 14 key homologous genes, known as involved in these responses in other plants, for each stages of treatment in both cultivars using RT-qPCR. Our results suggested that the increased expression of CsCBF1 and CsDHNs coupling with the accumulation of sucrose play key roles in conferring higher cold resistance in SCZ. Our findings have revealed key genes regulation responsible for cold resistance, which help to understand the cold-resistant mechanisms and guide breeding in tea plants.

Clustering fossil from primordial gravitational waves in anisotropic inflation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Emami, Razieh; Firouzjahi, Hassan, E-mail: emami@ipm.ir, E-mail: firouz@ipm.ir

2015-10-01

Inflationary models can correlate small-scale density perturbations with the long-wavelength gravitational waves (GW) in the form of the Tensor-Scalar-Scalar (TSS) bispectrum. This correlation affects the mass-distribution in the Universe and leads to the off-diagonal correlations of the density field modes in the form of the quadrupole anisotropy. Interestingly, this effect survives even after the tensor mode decays when it re-enters the horizon, known as the fossil effect. As a result, the off-diagonal correlation function between different Fourier modes of the density fluctuations can be thought as a way to probe the large-scale GW and the mechanism of inflation behind themore » fossil effect. Models of single field slow roll inflation generically predict a very small quadrupole anisotropy in TSS while in models of multiple fields inflation this effect can be observable. Therefore this large scale quadrupole anisotropy can be thought as a spectroscopy for different inflationary models. In addition, in models of anisotropic inflation there exists quadrupole anisotropy in curvature perturbation power spectrum. Here we consider TSS in models of anisotropic inflation and show that the shape of quadrupole anisotropy is different than in single field models. In fact, in these models, quadrupole anisotropy is projected into the preferred direction and its amplitude is proportional to g{sub *} N{sub e} where N{sub e} is the number of e-folds and g{sub *} is the amplitude of quadrupole anisotropy in curvature perturbation power spectrum. We use this correlation function to estimate the large scale GW as well as the preferred direction and discuss the detectability of the signal in the galaxy surveys like Euclid and 21 cm surveys.« less

On the inter-instrument and the inter-laboratory transferability of a tandem mass spectral reference library: 2. Optimization and characterization of the search algorithm.

PubMed

Oberacher, Herbert; Pavlic, Marion; Libiseller, Kathrin; Schubert, Birthe; Sulyok, Michael; Schuhmacher, Rainer; Csaszar, Edina; Köfeler, Harald C

2009-04-01

A sophisticated matching algorithm developed for highly efficient identity search within tandem mass spectral libraries is presented. For the optimization of the search procedure a collection of 410 tandem mass spectra corresponding to 22 compounds was used. The spectra were acquired in three different laboratories on four different instruments. The following types of tandem mass spectrometric instruments were used: quadrupole-quadrupole-time-of-flight (QqTOF), quadrupole-quadrupole-linear ion trap (QqLIT), quadrupole-quadrupole-quadrupole (QqQ), and linear ion trap-Fourier transform ion cyclotron resonance mass spectrometer (LIT-FTICR). The obtained spectra were matched to an established MS/MS-spectral library that contained 3759 MS/MS-spectra corresponding to 402 different reference compounds. All 22 test compounds were part of the library. A dynamic intensity cut-off, the search for neutral losses, and optimization of the formula used to calculate the match probability were shown to significantly enhance the performance of the presented library search approach. With the aid of these features the average number of correct assignments was increased to 98%. For statistical evaluation of the match reliability the set of fragment ion spectra was extended with 300 spectra corresponding to 100 compounds not included in the reference library. Performance was checked with the aid of receiver operating characteristic (ROC) curves. Using the magnitude of the match probability as well as the precursor ion mass as benchmarks to rate the obtained top hit, overall correct classification of a compound being included or not included in the mass spectrometric library, was obtained in more than 95% of cases clearly indicating a high predictive accuracy of the established matching procedure. Copyright (c) 2009 John Wiley & Sons, Ltd.

Electrostatic design and beam transport for a folded tandem electrostatic quadrupole accelerator facility for accelerator-based boron neutron capture therapy.

PubMed

Vento, V Thatar; Bergueiro, J; Cartelli, D; Valda, A A; Kreiner, A J

2011-12-01

Within the frame of an ongoing project to develop a folded Tandem-Electrostatic-Quadrupole (TESQ) accelerator facility for Accelerator-Based Boron Neutron Capture Therapy (AB-BNCT), we discuss here the electrostatic design of the machine, including the accelerator tubes with electrostatic quadrupoles and the simulations for the transport and acceleration of a high intensity beam. Copyright © 2011 Elsevier Ltd. All rights reserved.

Higher order parametric excitation modes for spaceborne quadrupole mass spectrometers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gershman, D. J.; Block, B. P.; Rubin, M.

This paper describes a technique to significantly improve upon the mass peak shape and mass resolution of spaceborne quadrupole mass spectrometers (QMSs) through higher order auxiliary excitation of the quadrupole field. Using a novel multiresonant tank circuit, additional frequency components can be used to drive modulating voltages on the quadrupole rods in a practical manner, suitable for both improved commercial applications and spaceflight instruments. Auxiliary excitation at frequencies near twice that of the fundamental quadrupole RF frequency provides the advantages of previously studied parametric excitation techniques, but with the added benefit of increased sensed excitation amplitude dynamic range and themore » ability to operate voltage scan lines through the center of upper stability islands. Using a field programmable gate array, the amplitudes and frequencies of all QMS signals are digitally generated and managed, providing a robust and stable voltage control system. These techniques are experimentally verified through an interface with a commercial Pfeiffer QMG422 quadrupole rod system. When operating through the center of a stability island formed from higher order auxiliary excitation, approximately 50% and 400% improvements in 1% mass resolution and peak stability were measured, respectively, when compared with traditional QMS operation. Although tested with a circular rod system, the presented techniques have the potential to improve the performance of both circular and hyperbolic rod geometry QMS sensors.« less

{sup 1}H NMR relaxometry and quadrupole relaxation enhancement as a sensitive probe of dynamical properties of solids—[C(NH{sub 2}){sub 3}]{sub 3}Bi{sub 2}I{sub 9} as an example

DOE Office of Scientific and Technical Information (OSTI.GOV)

Florek-Wojciechowska, M.; Wojciechowski, M.; Brym, Sz.

{sup 1}H nuclear magnetic resonance relaxometry has been applied to reveal information on dynamics and structure of Gu{sub 3}Bi{sub 2}I{sub 9} ([Gu = C(NH{sub 2}){sub 3}] denotes guanidinium cation). The data have been analyzed in terms of a theory of quadrupole relaxation enhancement, which has been extended here by including effects associated with quadrupole ({sup 14}N) spin relaxation caused by a fast fluctuating component of the electric field gradient tensor. Two motional processes have been identified: a slow one occurring on a timescale of about 8 × 10{sup −6} s which has turned out to be (almost) temperature independent, andmore » a fast process in the range of 10{sup −9} s. From the {sup 1}H-{sup 14}N relaxation contribution (that shows “quadrupole peaks”) the quadrupole parameters, which are a fingerprint of the arrangement of the anionic network, have been determined. It has been demonstrated that the magnitude of the quadrupole coupling considerably changes with temperature and the changes are not caused by phase transitions. At the same time, it has been shown that there is no evidence of abrupt changes in the cationic dynamics and the anionic substructure upon the phase transitions.« less

New method in muon-hadron absorption on Thx DUO2 nano material structure at 561 MHz quantum gyro-magnetic

NASA Astrophysics Data System (ADS)

Hardiyanto, M.; Ermawaty, I. R.

2018-01-01

We present an experimental of muan-hadron tunneling chain investigation with new methods of Thx DUO2 nano structure based on Josephson’s tunneling and Abrikosov-Balseiro-Russel (ABR) formulation with quantum quadrupole interacting with a strongly localized high gyro-magnetic optical field as encountered in high-resolution near-field optical microscopy for 1.2 nano meter lambda-function. The strong gradients of these localized gyro-magnetic fields suggest that higher-order multipolar interactions will affect the standard magnetic quadrupole transition rates in 1.8 x 103 currie/mm fuel energy in nuclear moderator pool and selection rules with quatum dot. For muan-hadron absorption in Josephson’s tunnelling quantum quadrupole in the strong confinement limit we calculated the inter band of gyro-magnetic quadrupole absorption rate and the associated selection rules. Founded that the magnetic quadrupole absorption rate is comparable with the absorption rate calculated in the gyro-magneticdipole approximation of ThxDUO2 nano material structure. This implies that near-field optical techniques can extend the range of spectroscopic measurements for 545 MHz at quantum gyro-magnetic field until 561 MHz deployment quantum field at B around 455-485 tesla beyond the standard dipole approximation. However, we also show that spatial resolution could be improved by the selective excitation of ABR formulation in quantum quadrupole transitions.

Quadrupole-Quadrupole Interactions to Control Plasmon-Induced Transparency

NASA Astrophysics Data System (ADS)

Rana, Goutam; Deshmukh, Prathmesh; Palkhivala, Shalom; Gupta, Abhishek; Duttagupta, S. P.; Prabhu, S. S.; Achanta, VenuGopal; Agarwal, G. S.

2018-06-01

Radiative dipolar resonance with Lorentzian line-shape induces the otherwise dark quadrupolar resonances resulting in electromagnetically induced transparency (EIT). The two interfering excitation pathways of the dipole are earlier shown to result in a Fano line shape with a high figure of merit suitable for sensing. In metamaterials made of metal nanorods or antennas, the plasmonic EIT (PIT) efficiency depends on the overlap of the dark and bright mode spectra as well as the asymmetry resulting from the separation between the monomer (dipole) and dimer (quadrupole) that governs the coupling strength. Increasing asymmetry in these structures leads to the reduction of the figure of merit due to a broadening of the Fano resonance. We demonstrate a PIT system in which the simultaneous excitation of two dipoles result in double PIT. The corresponding two quadrupoles interact and control the quality factor (Q ) of the PIT resonance. We show an antiresonancelike symmetric line shape with nonzero asymmetry factors. The PIT resonance vanishes due to quadrupole-quadrupole coupling. A Q factor of more than 100 at 0.977 THz is observed, which is limited by the experimental resolution of 6 GHz. From polarization-dependent studies we show that the broadening of the Lorentzian resonance is due to scattering-induced excitation of orthogonally oriented dipoles in the monomer and dimer bars in the terahertz regime. The high Q factors in the terahertz frequency region demonstrated here are interesting for sensing application.

Induced CMB quadrupole from pointing offsets

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moss, Adam; Scott, Douglas; Sigurdson, Kris, E-mail: adammoss@phas.ubc.ca, E-mail: dscott@phas.ubc.ca, E-mail: krs@phas.ubc.ca

2011-01-01

Recent claims in the literature have suggested that the WMAP quadrupole is not primordial in origin, and arises from an aliasing of the much larger dipole field because of incorrect satellite pointing. We attempt to reproduce this result and delineate the key physics leading to the effect. We find that, even if real, the induced quadrupole would be smaller than the WMAP value. We discuss reasons why the WMAP data are unlikely to suffer from this particular systematic effect, including the implications for observations of point sources. Given this evidence against the reality of the effect, the similarity between themore » pointing-offset-induced signal and the actual quadrupole then appears to be quite puzzling. However, we find that the effect arises from a convolution between the gradient of the dipole field and anisotropic coverage of the scan direction at each pixel. There is something of a directional conspiracy here — the dipole signal lies close to the Ecliptic Plane, and its direction, together with the WMAP scan strategy, results in a strong coupling to the Y{sub 2,−1} component in Ecliptic co-ordinates. The dominant strength of this component in the measured quadrupole suggests that one should exercise increased caution in interpreting its estimated amplitude. The Planck satellite has a different scan strategy which does not so directly couple the dipole and quadrupole in this way and will soon provide an independent measurement.« less

High-dose diazepam facilitates core cooling during cold saline infusion in healthy volunteers.

PubMed

Hostler, David; Northington, William E; Callaway, Clifton W

2009-08-01

Studies have suggested that inducing mild hypothermia improves neurologic outcomes after traumatic brain injury, major stroke, cardiac arrest, or exertional heat illness. While infusion of cold normal saline is a simple and inexpensive method for reducing core temperature, human cold-defense mechanisms potentially make this route stressful or ineffective. We hypothesized that intravenous administration of diazepam during a rapid infusion of 30 mL.kg-1 of cold (4 degrees C) 0.9% saline to healthy subjects would be more comfortable and reduce core body temperature more than the administration of cold saline alone. Fifteen subjects received rapidly infused cold (4 degrees C) 0.9% saline. Subjects were randomly assigned to receive, intravenously, 20 mg diazepam (HIGH), 10 mg diazepam (LOW), or placebo (CON). Main outcomes were core temperature, skin temperature, and oxygen consumption. Data for the main outcomes were analyzed with generalized estimating equations to identify differences in group, time, or a group x time interaction. Core temperature decreased in all groups (CON, 1.0 +/- 0.2 degrees C; LOW, 1.4 +/- 0.2 degrees C; HIGH, 1.5 +/- 0.2 degrees C), while skin temperature was unchanged. Mean (95% CI) oxygen consumption was 315.3 (253.8, 376.9) mL.kg-1.min-1 in the CON group, 317.9 (275.5, 360.3) in the LOW group, and 226.1 (216.4, 235.9) in the HIGH group. Significant time and group x time interaction was observed for core temperature and oxygen consumption (p < 0.001). Administration of high-dose diazepam resulted in decreased oxygen consumption during cold saline infusion, suggesting that 20 mg of intravenous diazepam may reduce the shivering threshold without compromising respiratory or cardiovascular function.

An efficient and robust method for predicting helicopter rotor high-speed impulsive noise

NASA Technical Reports Server (NTRS)

Brentner, Kenneth S.

1996-01-01

A new formulation for the Ffowcs Williams-Hawkings quadrupole source, which is valid for a far-field in-plane observer, is presented. The far-field approximation is new and unique in that no further approximation of the quadrupole source strength is made and integrands with r(exp -2) and r(exp -3) dependence are retained. This paper focuses on the development of a retarded-time formulation in which time derivatives are analytically taken inside the integrals to avoid unnecessary computational work when the observer moves with the rotor. The new quadrupole formulation is similar to Farassat's thickness and loading formulation 1A. Quadrupole noise prediction is carried out in two parts: a preprocessing stage in which the previously computed flow field is integrated in the direction normal to the rotor disk, and a noise computation stage in which quadrupole surface integrals are evaluated for a particular observer position. Preliminary predictions for hover and forward flight agree well with experimental data. The method is robust and requires computer resources comparable to thickness and loading noise prediction.

Summary of Test Results of MQXFS1 - The First Short Model 150 mm Aperture $$Nb_3Sn$$ Quadrupole for the High-Luminosity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stoynev, S.; et al.

The development ofmore » $$Nb_3Sn$$ quadrupole magnets for the High-Luminosity LHC upgrade is a joint venture between the US LHC Accelerator Research Program (LARP)* and CERN with the goal of fabricating large aperture quadrupoles for the LHC in-teraction regions (IR). The inner triplet (low-β) NbTi quadrupoles in the IR will be replaced by the stronger Nb3Sn magnets boosting the LHC program of having 10-fold increase in integrated luminos-ity after the foreseen upgrades. Previously LARP conducted suc-cessful tests of short and long models with up to 120 mm aperture. The first short 150 mm aperture quadrupole model MQXFS1 was assembled with coils fabricated by both CERN and LARP. The magnet demonstrated strong performance at the Fermilab’s verti-cal magnet test facility reaching the LHC operating limits. This paper reports the latest results from MQXFS1 tests with changed pre-stress levels. The overall magnet performance, including quench training and memory, ramp rate and temperature depend-ence, is also summarized.« less

Measurements of the microwave spectrum, Re-H bond length, and Re quadrupole coupling for HRe(CO)5

NASA Astrophysics Data System (ADS)

Kukolich, Stephen G.; Sickafoose, Shane M.

1993-11-01

Rotational transition frequencies for rhenium pentacarbonyl hydride were measured in the 4-10 GHz range using a Flygare-Balle type microwave spectrometer. The rotational constants and Re nuclear quadrupole coupling constants for the four isotopomers, (1) H187Re(CO)5, (2) H185Re(CO)5, (3) D187Re(CO)5, and (4) D185Re(CO)5, were obtained from the spectra. For the most common isotopomer, B(1)=818.5464(2) MHz and eq Q(187Re)=-900.13(3) MHz. The Re-H bond length (r0) determined by fitting the rotational constants is 1.80(1) Å. Although the Re atom is located at a site of near-octahedral symmetry, the quadrupole coupling is large due to the large Re nuclear moments. A 2.7% increase in Re quadrupole coupling was observed for D-substituted isotopomers, giving a rather large isotope effect on the quadrupole coupling. The Cax-Re-Ceq angle is 96(1)°, when all Re-C-O angles are constrained to 180°.

Recirculating systems for Atlantic salmon (Salmo salar) at the USDA ARS National Cold Water Marine Aquaculture Center (Franklin, Maine

USDA-ARS?s Scientific Manuscript database

The Northeastern U.S has the ideal location and unique opportunity to be a leader in cold-water marine finfish aquaculture. However, problems and regulations on environmental issues, mandatory stocking of 100 percent native North American salmon, and disease have impacted economic viability of the U...

Teaching Foreign Policy in the Post-Cold War Era. ERIC Digest.

ERIC Educational Resources Information Center

Graseck, Susan

This ERIC Digest discusses issues relating to teaching about U.S. foreign policy in the changing international environment following the end of the Cold War era and the disintegration of the Soviet Union. The document treats: (1) the need and rationale for teaching and learning about current foreign policy issues; (2) main themes in foreign policy…

Evidence of major genes affecting bacterial cold water disease resistance in rainbow trout using Bayesian methods of complex segregation analysis

USDA-ARS?s Scientific Manuscript database

Bacterial cold water disease (BCWD) causes significant economic loss in salmonid aquaculture. We previously detected genetic variation for BCWD resistance in our rainbow trout population, and a family-based selection program to improve resistance was initiated at the NCCCWA in 2005. The main objec...

Test results of the LARP Nb$$_3$$Sn quadrupole HQ03a

DOE PAGES

DiMarco, J.; G. Ambrosio; Chlachidze, G.; ...

2016-03-09

The US LHC Accelerator Research Program (LARP) has been developingmore » $$Nb_3Sn$$ quadrupoles of progressively increasing performance for the high luminosity upgrade of the Large Hadron Collider. The 120 mm aperture High-field Quadrupole (HQ) models are the last step in the R&D phase supporting the development of the new IR Quadrupoles (MQXF). Three series of HQ coils were fabricated and assembled in a shell-based support structure, progressively optimizing the design and fabrication process. The final set of coils consistently applied the optimized design solutions, and was assembled in the HQ03a model. Furthermore, this paper reports a summary of the HQ03a test results, including training, mechanical performance, field quality and quench studies.« less

The clinical potential of Enhanced-ice-COLD-PCR.

PubMed

Tost, Jörg

2016-01-01

Enhanced-ice-COLD-PCR (E-ice-COLD-PCR) is a novel assay format that allows for the efficient enrichment and sensitive detection of all mutations in a region of interest using a chemically modified blocking oligonucleotide, which impedes the amplification of wild-type sequences. The assay is compatible with DNA extracted from tissue and cell-free circulating DNA. The main features of E-ice-COLD-PCR are the simplicity of the setup and the optimization of the assay, the use of standard laboratory equipment and the very short time to results (~4 h including DNA extraction, enrichment and sequence-based identification of mutations). E-ice-COLD-PCR is therefore a highly promising technology for a number of basic research as well as clinical applications including detection of clinically relevant mutated subclones and monitoring of treatment response or disease recurrence.

Global transcriptional profiling of a cold-tolerant rice variety under moderate cold stress reveals different cold stress response mechanisms.

PubMed

Zhao, Junliang; Zhang, Shaohong; Yang, Tifeng; Zeng, Zichong; Huang, Zhanghui; Liu, Qing; Wang, Xiaofei; Leach, Jan; Leung, Hei; Liu, Bin

2015-07-01

Gene expression profiling under severe cold stress (4°C) has been conducted in plants including rice. However, rice seedlings are frequently exposed to milder cold stresses under natural environments. To understand the responses of rice to milder cold stress, a moderately low temperature (8°C) was used for cold treatment prior to genome-wide profiling of gene expression in a cold-tolerant japonica variety, Lijiangxintuanheigu (LTH). A total of 5557 differentially expressed genes (DEGs) were found at four time points during moderate cold stress. Both the DEGs and differentially expressed transcription factor genes were clustered into two groups based on their expression, suggesting a two-phase response to cold stress and a determinative role of transcription factors in the regulation of stress response. The induction of OsDREB2A under cold stress is reported for the first time in this study. Among the anti-oxidant enzyme genes, glutathione peroxidase (GPX) and glutathione S-transferase (GST) were upregulated, suggesting that the glutathione system may serve as the main reactive oxygen species (ROS) scavenger in LTH. Changes in expression of genes in signal transduction pathways for auxin, abscisic acid (ABA) and salicylic acid (SA) imply their involvement in cold stress responses. The induction of ABA response genes and detection of enriched cis-elements in DEGs suggest that ABA signaling pathway plays a dominant role in the cold stress response. Our results suggest that rice responses to cold stress vary with the specific temperature imposed and the rice genotype. © 2014 Scandinavian Plant Physiology Society.

Measurement of picosecond lifetimes in neutron-rich Xe isotopes

NASA Astrophysics Data System (ADS)

Ilieva, S.; Kröll, Th.; Régis, J.-M.; Saed-Samii, N.; Blanc, A.; Bruce, A. M.; Fraile, L. M.; de France, G.; Hartig, A.-L.; Henrich, C.; Ignatov, A.; Jentschel, M.; Jolie, J.; Korten, W.; Köster, U.; Lalkovski, S.; Lozeva, R.; Mach, H.; Mǎrginean, N.; Mutti, P.; Paziy, V.; Regan, P. H.; Simpson, G. S.; Soldner, T.; Thürauf, M.; Ur, C. A.; Urban, W.; Warr, N.

2016-09-01

Background: Lifetimes of nuclear excited states in fission fragments have been studied in the past following isotope separation, thus giving access mainly to the fragments' daughters and only to long-lived isomeric states in the primary fragments. For the first time now, short-lived excited states in the primary fragments, produced in neutron-induced prompt fission of 235U and 241Pu, were studied within the EXILL&FATIMA campaign at the intense neutron-beam facility of the Institute Laue-Langevin in Grenoble. Purpose: We aim to investigate the quadrupole collective properties of neutron-rich even-even 138,140,142Xe isotopes lying between the double shell closure N =82 and Z =50 and a deformed region with octupole collectivity. Method: The γ rays emitted from the excited fragments were detected with a mixed array consisting of 8 HPGe EXOGAM Clover detectors (EXILL) and 16 LaBr3(Ce) fast scintillators (FATIMA). The detector system has the unique ability to select the interesting fragment making use of the high resolution of the HPGe detectors and determine subnanosecond lifetimes using the fast scintillators. For the analysis the generalized centroid difference method was used. Results: We show that quadrupole collectivity increases smoothly with increasing neutron number above the closed N =82 neutron shell. Our measurements are complemented by state-of-the-art theory calculations based on shell-model descriptions. Conclusions: The observed smooth increase in quadrupole collectivity is similar to the evolution seen in the measured masses of the xenon isotopic chain and is well reproduced by theory. This behavior is in contrast to higher Z even-even nuclei where abrupt change in deformation occurs around N =90 .

Electron configuration and hydrogen-bonding pattern in several thymine and uracil analogues studied by 1H-14N NQDR and DFT/QTAIM.

PubMed

Seliger, Janez; Žagar, Veselko; Latosińska, Magdalena; Latosińska, Jolanta Natalia

2012-08-02

Some thio- and aza-derivatives of natural nucleobases uracil and thymine: 2-thiouracil, 4-thiouracil, 6-methyl-2-thiouracil, 6-azauracil, and 6-aza-2-thiothymine have been studied experimentally in solid state by (1)H-(14)N NMR-NQR double resonance (NQDR) and theoretically by the Density Functional Theory (DFT)/Quantum Theory of Atoms in Molecules (QTAIM). The (14)N resonance frequencies have been measured at 173 and 295 K and assigned to particular nitrogen sites (-N═ and -NH-). The temperature factor has been found negligible. The changes in the molecular skeletons, electric charge distribution, intermolecular interactions pattern, and molecular aggregations caused by oxygen replacement with sulfur and carbon replacement with nitrogen are discussed in detail. Correlations between all the principal components of the (14)N quadrupole coupling tensor have been found helpful in the search for the experimental (14)N NQR frequencies, their assignment to a particular nitrogen positions and estimation of the strength of the inter- and intramolecular interactions. The variation in the NQR parameters have been mainly related to the variation in the population of π-electron orbital. For thiouracil derivatives a general trend is that the stronger the hydrogen bond is, the lower is the asymmetry parameter, while for thymine and 6-aza-2-thiotymine, the opposite relation holds. Differences in correlations of the principal components of the (14)N quadrupole coupling tensor at the amino and iminonitrogen positions in heterocyclic rings are discussed. The effect of C→H and C→N substitution at the amino nitrogen position and C→N substitution at the iminonitrogen position on the quadrupole coupling tensor is analyzed. This study also demonstrates the advantages of combining NQR and DFT/QTAIM to predict an unsolved crystalline structure of 4-thiouracil.

Characterization of the ELIMED Permanent Magnets Quadrupole system prototype with laser-driven proton beams

NASA Astrophysics Data System (ADS)

Schillaci, F.; Pommarel, L.; Romano, F.; Cuttone, G.; Costa, M.; Giove, D.; Maggiore, M.; Russo, A. D.; Scuderi, V.; Malka, V.; Vauzour, B.; Flacco, A.; Cirrone, G. A. P.

2016-07-01

Laser-based accelerators are gaining interest in recent years as an alternative to conventional machines [1]. In the actual ion acceleration scheme, energy and angular spread of the laser-driven beams are the main limiting factors for beam applications and different solutions for dedicated beam-transport lines have been proposed [2,3]. In this context a system of Permanent Magnet Quadrupoles (PMQs) has been realized [2] by INFN-LNS (Laboratori Nazionali del Sud of the Instituto Nazionale di Fisica Nucleare) researchers, in collaboration with SIGMAPHI company in France, to be used as a collection and pre-selection system for laser driven proton beams. This system is meant to be a prototype to a more performing one [3] to be installed at ELI-Beamlines for the collection of ions. The final system is designed for protons and carbons up to 60 MeV/u. In order to validate the design and the performances of this large bore, compact, high gradient magnetic system prototype an experimental campaign have been carried out, in collaboration with the group of the SAPHIR experimental facility at LOA (Laboratoire d'Optique Appliquée) in Paris using a 200 TW Ti:Sapphire laser system. During this campaign a deep study of the quadrupole system optics has been performed, comparing the results with the simulation codes used to determine the setup of the PMQ system and to track protons with realistic TNSA-like divergence and spectrum. Experimental and simulation results are good agreement, demonstrating the possibility to have a good control on the magnet optics. The procedure used during the experimental campaign and the most relevant results are reported here.

Observation of a quadrupole interaction for cubic imperfections exhibiting a dynamic Jahn-Teller effect.

NASA Technical Reports Server (NTRS)

Herrington, J. R.; Estle, T. L.; Boatner, L. A.

1972-01-01

The observation and interpretation of weak EPR transitions, identified as 'forbidden' transitions, establish the existence of a new type of quadrupole interaction for cubic-symmetry imperfections. This interaction is simply a consequence of the ground-vibronic-state degeneracy. The signs as well as the magnitudes of the quadrupole-coupling coefficients are determined experimentally. These data agree well with the predictions of crystal field theory modified to account for a weak-to-moderate vibronic interaction (i.e., a dynamic Jahn-Teller effect).

Dynamical quadrupole structure factor of frustrated ferromagnetic chain

NASA Astrophysics Data System (ADS)

Onishi, Hiroaki

2018-05-01

We investigate the dynamical quadrupole structure factor of a spin-1/2 J1-J2 Heisenberg chain with competing ferromagnetic J1 and antiferromagnetic J2 in a magnetic field by exploiting density-matrix renormalization group techniques. In a field-induced spin nematic regime, we observe gapless excitations at q = π according to quasi-long-range antiferro-quadrupole correlations. The gapless excitation mode has a quadratic form at the saturation, while it changes into a linear dispersion as the magnetization decreases.

Nuclear Quadrupole Resonance (NQR) Method and Probe for Generating RF Magnetic Fields in Different Directions to Distinguish NQR from Acoustic Ringing Induced in a Sample

DTIC Science & Technology

1997-08-01

77,719 TITLE OF THE INVENTION NUCLEAR QUADRUPOLE RESONANCE ( NQR ) METHOD AND PROBE FOR GENERATING RF MAGNETIC FIELDS IN DIFFERENT DIRECTIONS TO...DISTINGUISH NQR FROM ACOUSTIC RINGING INDUCED IN A SAMPLE BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a...nuclear quadrupole 15 resonance ( NQR ) method and probe for generating RF magnetic fields in different directions towards a sample. More specifically

Apparatus and method of dissociating ions in a multipole ion guide

DOEpatents

Webb, Ian K.; Tang, Keqi; Smith, Richard D.; Ibrahim, Yehia M.; Anderson, Gordon A.

2014-07-08

A method of dissociating ions in a multipole ion guide is disclosed. A stream of charged ions is supplied to the ion guide. A main RF field is applied to the ion guide to confine the ions through the ion guide. An excitation RF field is applied to one pair of rods of the ion guide. The ions undergo dissociation when the applied excitation RF field is resonant with a secular frequency of the ions. The multipole ion guide is, but not limited to, a quadrupole, a hexapole, and an octopole.

The absolute magnitude distribution of cold classical Kuiper belt objects

NASA Astrophysics Data System (ADS)

Petit, Jean-Marc; Bannister, Michele T.; Alexandersen, Mike; Chen, Ying-Tung; Gladman, Brett; Gwyn, Stephen; Kavelaars, JJ; Volk, Kathryn

2016-10-01

We report measurements of the low inclination component of the main Kuiper Belt showing a size freqency distribution very steep for sizes larger than H_r ~ 6.5-7.0 and then a flattening to shallower slope that is still steeper than the collisional equilibrium slope.The Outer Solar System Origins Survey (OSSOS) is ongoing and is expected to detect over 500 TNOs in a precisely calibrated and characterized survey. Combining our current sample with CFEPS and the Alexandersen et al. (2015) survey, we analyse a sample of ~180 low inclination main classical (cold) TNOs, with absolute magnitude H_r (SDSS r' like flter) in the range 5 to 8.8. We confirm that the H_r distribution can be approximated by an exponential with a very steep slope (>1) at the bright end of the distribution, as has been recognized long ago. A transition to a shallower slope occurs around H_r ~ 6.5 - 7.0, an H_r mag identified by Fraster et al (2014). Faintward of this transition, we find a second exponential to be a good approximation at least until H_r ~ 8.5, but with a slope significantly steeper than the one proposed by Fraser et al. (2014) or even the collisional equilibrium value of 0.5.The transition in the cold TNO H_r distribution thus appears to occur at larger sizes than is observed in the high inclination main classical (hot) belt, an important indicator of a different cosmogony for these two sub-components of the main classical Kuiper belt. Given the largish slope faintward of the transition, the cold population with ~100 km diameter may dominate the mass of the Kuiper belt in the 40 AU < a < 47 au region.

Cold Test Operation of the German VEK Vitrification Plant

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fleisch, J.; Schwaab, E.; Weishaupt, M.

2008-07-01

In 2007 the German High-Level Liquid Waste (HLLW) Vitrification plant VEK (Verglasungseinrichtung Karlsruhe) has passed a three months integral cold test operation as final step before entering the hot phase. The overall performance of the vitrification process equipment with a liquid-fed ceramic glass melter as main component proved to be completely in line with the requirements of the regulatory body. The retention efficiency of main radioactive-bearing elements across melter and wet off-gas treatment system exceeded the design values distinctly. The strategy to produce a specified waste glass could be successfully demonstrated. The results of the cold test operation allow enteringmore » the next step of hot commissioning, i.e. processing of approximately 2 m{sup 3} of diluted HLLW. In summary: An important step of the VEK vitrification plant towards hot operation has been the performance of the cold test operation from April to July 2007. This first integral operation was carried out under boundary conditions and rules established for radioactive operation. Operation and process control were carried out following the procedure as documented in the licensed operational manuals. The function of the process technology and the safe operation could be demonstrated. No severe problems were encountered. Based on the positive results of the cold test, application of the license for hot operation has been initiated and is expected in the near future. (authors)« less

This plant treats that illness? The hot-cold system and therapeutic procedures mediate medicinal plant use in San Miguel Tulancingo, Oaxaca, Mexico.

PubMed

García-Hernández, Karina Yaredi; Vibrans, Heike; Rivas-Guevara, María; Aguilar-Contreras, Abigail

2015-04-02

Understanding the reasoning behind the choice of medicinal plants is relevant for both pharmacological and ethnobotanical quantitative studies. In this study, we analyze how the traditional medical system influences the choice of medicinal plants in a Mexican indigenous population. The study area was San Miguel Tulancingo, Oaxaca, Mexico, and the studied people the Rru ngigua (or Chocholtecs), an Otomangue group with only a few hundred speakers remaining. Through in-depth and repeated interviews of four traditional healers and ethnobotanical collections, we identified, described and classified the medicinal plants, the nosological units, the therapeutic procedures and the reasoning behind medicinal plant and treatment choice. The hot-cold system, which considers illness to be a result of humoral imbalance, strongly influences treatment choice. "Hot" plants are used mainly to treat "cold" diseases, and vice versa. With some variation, plants are selected mainly for this hot-or-cold property, and the specific plant species is often not very relevant. In addition, many plants are associated with specific healing procedures, such as sweat baths. The procedures, in turn, may be used to treat various diseases. The study shows that the relationship between medicinal plants and treated diseases is complex and indirect in most cases. It is strongly influenced by the hot-cold concept and by therapeutic procedures. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Cold Atmospheric Plasma: methods of production and application in dentistry and oncology

PubMed Central

2013-01-01

Cold Atmospheric Plasma is an ionized gas that has recently been extensively studied by researchers as a possible therapy in dentistry and oncology. Several different gases can be used to produce Cold Atmospheric Plasma such as Helium, Argon, Nitrogen, Heliox, and air. There are many methods of production by which cold atmospheric plasma is created. Each unique method can be used in different biomedical areas. In dentistry, researchers have mostly investigated the antimicrobial effects produced by plasma as a means to remove dental biofilms and eradicate oral pathogens. It has been shown that reactive oxidative species, charged particles, and UV photons play the main role. Cold Atmospheric Plasma has also found a minor, but important role in tooth whitening and composite restoration. Furthermore, it has been demonstrated that Cold Atmospheric Plasma induces apoptosis, necrosis, cell detachment, and senescence by disrupting the S phase of cell replication in tumor cells. This unique finding opens up its potential therapy in oncology. PMID:24083477

Cold sprayed WO3 and TiO2 electrodes for photoelectrochemical water and methanol oxidation in renewable energy applications.

PubMed

Haisch, Christoph; Schneider, Jenny; Fleisch, Manuel; Gutzmann, Henning; Klassen, Thomas; Bahnemann, Detlef W

2017-10-03

Films prepared by cold spray have potential applications as photoanodes in electrochemical water splitting and waste water purification. In the present study cold sprayed photoelectrodes produced with WO 3 (active under visible light illumination) and TiO 2 (active under UV illumination) on titanium metal substrates were investigated as photoanodes for the oxidation of water and methanol, respectively. Methanol was chosen as organic model pollutant in acidic electrolytes. Main advantages of the cold sprayed photoelectrodes are the improved metal-semiconductor junctions and the superior mechanical stability. Additionally, the cold spray method can be utilized as a large-scale electrode fabrication technique for photoelectrochemical applications. Incident photon to current efficiencies reveal that cold sprayed TiO 2 /WO 3 photoanodes exhibit the best photoelectrochemical properties with regard to the water and methanol oxidation reactions in comparison with the benchmark photocatalyst Aeroxide TiO 2 P25 due to more efficient harvesting of the total solar light irradiation related to their smaller band gap energies.

Spin Tracking of Polarized Protons in the Main Injector at Fermilab

DOE Office of Scientific and Technical Information (OSTI.GOV)

Xiao, M.; Lorenzon, W.; Aldred, C.

2016-07-01

The Main Injector (MI) at Fermilab currently produces high-intensity beams of protons at energies of 120 GeV for a variety of physics experiments. Acceleration of polarized protons in the MI would provide opportunities for a rich spin physics program at Fermilab. To achieve polarized proton beams in the Fermilab accelerator complex, shown in Fig.1.1, detailed spin tracking simulations with realistic parameters based on the existing facility are required. This report presents studies at the MI using a single 4-twist Si-berian snake to determine the depolarizing spin resonances for the relevant synchrotrons. Results will be presented first for a perfect MImore » lattice, followed by a lattice that includes the real MI imperfections, such as the measured magnet field errors and quadrupole misalignments. The tolerances of each of these factors in maintaining polariza-tion in the Main Injector will be discussed.« less

Cold exposure down-regulates immune response pathways in ferret aortic perivascular adipose tissue.

PubMed

Reynés, Bàrbara; van Schothorst, Evert M; García-Ruiz, Estefanía; Keijer, Jaap; Palou, Andreu; Oliver, Paula

2017-05-03

Perivascular adipose tissue (PVAT) surrounds blood vessels and releases paracrine factors, such as cytokines, which regulate local inflammation. The inflammatory state of PVAT has an important role in vascular disease; a pro-inflammatory state has been related with atherosclerosis development, whereas an anti-inflammatory one is protective. Cold exposure beneficially affects immune responses and, could thus impact the pathogenesis of cardiovascular diseases. In this study, we investigated the effects of one-week of cold exposure at 4°C of ferrets on aortic PVAT (aPVAT) versus subcutaneous adipose tissue. Ferrets were used because of the similarity of their adipose tissues to those of humans. A ferret-specific Agilent microarray was designed to cover the complete ferret genome and global gene expression analysis was performed. The data showed that cold exposure altered gene expression mainly in aPVAT. Most of the regulated genes were associated with cell cycle, immune response and gene expression regulation, and were mainly down-regulated. Regarding the effects on immune response, cold acclimation decreased the expression of genes involved in antigen recognition and presentation, cytokine signalling and immune system maturation and activation. This immunosuppressive gene expression pattern was depot-specific, as it was not observed in the inguinal subcutaneous depot. Interestingly, this depression in immune response related genes was also evident in peripheral blood mononuclear cells (PBMC). In conclusion, these results reveal that cold acclimation produces an inhibition of immune response-related pathways in aPVAT, reflected in PBMC, indicative of an anti-inflammatory response, which can potentially be exploited for the enhancement or maintenance of cardiovascular health.

Comprehensive analysis of a multidimensional liquid chromatography mass spectrometry dataset acquired on a quadrupole selecting, quadrupole collision cell, time-of-flight mass spectrometer: I. How much of the data is theoretically interpretable by search engines?

PubMed

Chalkley, Robert J; Baker, Peter R; Hansen, Kirk C; Medzihradszky, Katalin F; Allen, Nadia P; Rexach, Michael; Burlingame, Alma L

2005-08-01

An in-depth analysis of a multidimensional chromatography-mass spectrometry dataset acquired on a quadrupole selecting, quadrupole collision cell, time-of-flight (QqTOF) geometry instrument was carried out. A total of 3269 CID spectra were acquired. Through manual verification of database search results and de novo interpretation of spectra 2368 spectra could be confidently determined as predicted tryptic peptides. A detailed analysis of the non-matching spectra was also carried out, highlighting what the non-matching spectra in a database search typically are composed of. The results of this comprehensive dataset study demonstrate that QqTOF instruments produce information-rich data of which a high percentage of the data is readily interpretable.

Nuclear deformation in the laboratory frame

NASA Astrophysics Data System (ADS)

Gilbreth, C. N.; Alhassid, Y.; Bertsch, G. F.

2018-01-01

We develop a formalism for calculating the distribution of the axial quadrupole operator in the laboratory frame within the rotationally invariant framework of the configuration-interaction shell model. The calculation is carried out using a finite-temperature auxiliary-field quantum Monte Carlo method. We apply this formalism to isotope chains of even-mass samarium and neodymium nuclei and show that the quadrupole distribution provides a model-independent signature of nuclear deformation. Two technical advances are described that greatly facilitate the calculations. The first is to exploit the rotational invariance of the underlying Hamiltonian to reduce the statistical fluctuations in the Monte Carlo calculations. The second is to determine quadruple invariants from the distribution of the axial quadrupole operator in the laboratory frame. This allows us to extract effective values of the intrinsic quadrupole shape parameters without invoking an intrinsic frame or a mean-field approximation.

Mixing Hot and Cold Water Streams at a T-Junction

ERIC Educational Resources Information Center

Sharp, David; Zhang, Mingqian; Xu, Zhenghe; Ryan, Jim; Wanke, Sieghard; Afacan, Artin

2008-01-01

A simple mixing of a hot- and cold-water stream at a T-junction was investigated. The main objective was to use mass and energy balance equations to predict mass low rates and the temperature of the mixed stream after the T-junction, and then compare these with the measured values. Furthermore, the thermocouple location after the T-junction and…

Evidence of major genes for resistance to bacterial cold-water disease in rainbow trout using mixed inheritance multiple-threshold models and Bayesian segregation analysis

USDA-ARS?s Scientific Manuscript database

PURPOSE: Bacterial cold water disease (BCWD) causes significant economic loss in salmonid aquaculture, and in 2005, a rainbow trout breeding program was initiated at the NCCCWA to select for increased disease survival. The main objectives of this study were to determine the mode of inheritance of di...

Analysis of Slab-column Shearwall Structure of 6000 Tons Cold Storage

NASA Astrophysics Data System (ADS)

He, Dongqing; Song, Pengwei; Jie, Pengyu

2018-05-01

Combining with the functional requirements, the site conditions and the 6000 tons load characteristics of cold storage, so determine its structure system for the slab-column-shear wall structure. The paper recommends the design of foundation, the settings of column cap, the arrangement of shear wall, the punching shear of floor slab and the analysis and calculation results of main structure. By addition shear wall in slab-column structure to increase the overall stiffness of structure and improve the seismic performance of structure. Take the detached form between the main structure and the external wall insulation, while set anchorage beam between in the main floor and the ring beam along the axis of the column grid to enhance the overall stability of the external wall insulation.

The Evolution of Second-Phase Particles in 6111 Aluminum Alloy Processed by Hot and Cold Rolling

NASA Astrophysics Data System (ADS)

Zhang, Lixin; Wang, Yihan; Ni, Song; Chen, Gang; Li, Kai; Du, Yong; Song, Min

2018-03-01

The evolution of coarse Al9.9Fe2.65Ni1.45 phase, spherical Al12(Mn,Fe)3Si phase and rod-like Q phase in a 6111 aluminum alloy during hot and cold rolling deformation processes was systematically investigated in this work. The results showed that the coarse Al9.9Fe2.65Ni1.45 particles are mainly distributed at the grain boundaries, accompanied by the co-formation of Al12(Fe,Mn)3Si phase and Mg2Si phase, while the spherical Al12(Mn,Fe)3Si particles are mainly distributed in the grain interiors. Hot rolling has little effects on the size and distribution of both phases, but cold deformation can severely decrease the size of the particles by breaking the particles into small pieces. In addition, the temperature of 450 °C is not high enough for the dissolution of Q phase in the Al matrix, but the Q particles can be broken into small pieces due to the stress concentration during both hot and cold rolling deformation. In addition, the influences of phase evolution, dislocations and recrystallization on the mechanical properties evolution were also discussed.

Peripheral nervous control of cold-induced reduction in the respiratory quotient of the rat

NASA Astrophysics Data System (ADS)

Refinetti, Roberto

1990-03-01

Cold-exposed rats show a reduction in the respiratory quotient which is indicative of a relative shift from carbohydrates to lipids as substrates for oxidative metabolism. In the present study, the effects of food deprivation and cold exposure on the respiratory quotient were observed. In addition, the involvement of the three main branches of the peripheral nervous system (sympathetic, parasympathetic, and somatic) was investigated by means of synaptic blockade with propranolol, atropine, and quinine, respectively. Both propranolol and quinine blocked the cold-induced decrease in respiratory quotient and increase in heat production, whereas atropine had only minor and very brief effects. It is concluded that both the sympathetic and somatic branches are involved in the metabolic changes associated with cold-induced thermogenesis and that the increase in metabolic heat production involves a shift from carbohydrate to lipid utilization irrespective of which of the two branches is activated.

Comprehensive blood plasma lipidomics by liquid chromatography/quadrupole time-of-flight mass spectrometry.

PubMed

Sandra, Koen; Pereira, Alberto Dos Santos; Vanhoenacker, Gerd; David, Frank; Sandra, Pat

2010-06-18

A lipidomics strategy, combining high resolution reversed-phase liquid chromatography (RPLC) with high resolution quadrupole time-of-flight mass spectrometry (QqTOF), is described. The method has carefully been assessed in both a qualitative and a quantitative fashion utilizing human blood plasma. The inherent low technical variability associated with the lipidomics method allows to measure 65% of the features with an intensity RSD value below 10%. Blood plasma lipid spike-in experiments demonstrate that relative concentration differences smaller than 25% can readily be revealed by means of a t-test. Utilizing an advanced identification strategy, it is shown that the detected features mainly originate from (lyso-)phospholipids, sphingolipids, mono-, di- and triacylglycerols and cholesterol esters. The high resolution offered by the up-front RPLC step further allows to discriminate various isomeric species associated with the different lipid classes. The added value of utilizing a Jetstream electrospray ionization (ESI) source over a regular ESI source in lipidomics is for the first time demonstrated. In addition, the application of ultra high performance LC (UHPLC) up to 1200bar to extend the peak capacity or increase productivity is discussed. Copyright (c) 2010 Elsevier B.V. All rights reserved.

Multi-analysis strategy for metabolism of Andrographis paniculata in rat using liquid chromatography/quadrupole time-of-flight mass spectrometry.

PubMed

Li, Wenlan; Sun, Xiangming; Xu, Ying; Wang, Xuezhi; Bai, Jing; Ji, Yubin

2015-07-01

Compared with chemical drugs, it is a huge challenge to identify active ingredients of multicomponent traditional Chinese medicine (TCM). For most TCMs, metabolism investigation of absorbed constituents is a feasible way to clarify the active material basis. Although Andrographis paniculata (AP) has been extensively researched by domestic and foreign scholars, its metabolism has seldom been fully addressed to date. In this paper, high-performance liquid chromatography/quadrupole time-of-flight mass spectrometry was applied to analysis and characterization of AP metabolism in rat urine and feces samples after oral administration of ethanol extract. The differences in metabolites and metabolic pathways between the two biological samples were further compared. The chemical structures of 20 components were tentatively identified from drug-treated biological samples, including six prototype components and 14 metabolites, which underwent such main metabolic pathways as hydrolyzation, hydrogenation, dehydroxylation, deoxygenation, methylation, glucuronidation, sulfonation and sulfation. Two co-existing components were found in urine and feces samples, suggesting that some ingredients' metabolic processes were not unique. This study provides a comprehensive report on the metabolism of AP in rats, which will be helpful for understanding its mechanism. Copyright © 2014 John Wiley & Sons, Ltd.

Evaluation and Compensation of Detector Solenoid Effects in the JLEIC

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wei, Guohui; Morozov, Vasiliy; Zhang, Yuhong

2016-05-01

The JLEIC detector solenoid has a strong 3 T field in the IR area, and its tails extend over a range of several meters. One of the main effects of the solenoid field is coupling of the horizontal and vertical betatron motions which must be corrected in order to preserve the dynamical stability and beam spot size match at the IP. Additional effects include influence on the orbit and dispersion caused by the angle between the solenoid axis and the beam orbit. Meanwhile it affects ion polarization breaking the figure-8 spin symmetry. Crab dynamics further complicates the picture. All ofmore » these effects have to be compensated or accounted for. The proposed correction system is equivalent to the Rotating Frame Method. However, it does not involve physical rotation of elements. It provides local compensation of the solenoid effects independently for each side of the IR. It includes skew quadrupoles, dipole correctors and anti-solenoids to cancel perturbations to the orbit and linear optics. The skew quadrupoles and FFQ together generate an effect equivalent to adjustable rotation angle to do the decoupling task. Details of all of the correction systems are presented.« less

Modeling Aerodynamically Generated Sound of Helicopter Rotors

NASA Technical Reports Server (NTRS)

Brentner, Kenneth S.; Farassat, F.

2002-01-01

A great deal of progress has been made in the modeling of aerodynamically generated sound of rotors over the past decade. Although the modeling effort has focused on helicopter main rotors, the theory is generally valid for a wide range of rotor configurations. The Ffowcs Williams Hawkings (FW-H) equation has been the foundation for much of the development. The monopole and dipole source terms of the FW-H equation account for the thickness and loading noise, respectively. Bladevortex-interaction noise and broadband noise are important types of loading noise, hence much research has been directed toward the accurate modeling of these noise mechanisms. Both subsonic and supersonic quadrupole noise formulations have been developed for the prediction of high-speed impulsive noise. In an effort to eliminate the need to compute the quadrupole contribution, the FW-H equation has also been utilized on permeable surfaces surrounding all physical noise sources. Comparisons of the Kirchhoff formulation for moving surfaces with the FW-H equation have shown that the Kirchhoff formulation for moving surfaces can give erroneous results for aeroacoustic problems. Finally, significant progress has been made incorporating the rotor noise models into full vehicle noise prediction tools.

Instrumentation status of the low-b magnet systems at the Large Hadron Collider (LHC)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Darve, C.; /Fermilab; Balle, C.

2011-05-01

The low-{beta} magnet systems are located in the Large Hadron Collider (LHC) insertion regions around the four interaction points. They are the key elements in the beams focusing/defocusing process allowing proton collisions at luminosity up to 10{sup 34}cm{sup -2}s{sup -1}. Those systems are a contribution of the US-LHC Accelerator project. The systems are mainly composed of the quadrupole magnets (triplets), the separation dipoles and their respective electrical feed-boxes (DFBX). The low-{beta} magnet systems operate in an environment of extreme radiation, high gradient magnetic field and high heat load to the cryogenic system due to the beam dynamic effect. Due tomore » the severe environment, the robustness of the diagnostics is primordial for the operation of the triplets. The hardware commissioning phase of the LHC was completed in February 2010. In the sake of a safer and more user-friendly operation, several consolidations and instrumentation modifications were implemented during this commissioning phase. This paper presents the instrumentation used to optimize the engineering process and operation of the final focusing/defocusing quadrupole magnets for the first years of operation.« less

Peptide profiling of Internet-obtained Cerebrolysin using high performance liquid chromatography - electrospray ionization ion trap and ultra high performance liquid chromatography - ion mobility - quadrupole time of flight mass spectrometry.

PubMed

Gevaert, Bert; D'Hondt, Matthias; Bracke, Nathalie; Yao, Han; Wynendaele, Evelien; Vissers, Johannes Petrus Cornelis; De Cecco, Martin; Claereboudt, Jan; De Spiegeleer, Bart

2015-09-01

Cerebrolysin, a parenteral peptide preparation produced by controlled digestion of porcine brain proteins, is an approved nootropic medicine in some countries. However, it is also easily and globally available on the Internet. Nevertheless, until now, its exact chemical composition was unknown. Using high performance liquid chromatography (HPLC) coupled to ion trap and ultra high performance liquid chromatography (UHPLC) coupled to quadrupole-ion mobility-time-of-flight mass spectrometry (Q-IM-TOF MS), combined with UniProt pig protein database search and PEAKS de novo sequencing, we identified 638 unique peptides in an Internet-obtained Cerebrolysin sample. The main components in this sample originate from tubulin alpha- and beta-chain, actin, and myelin basic protein. No fragments of known neurotrophic factors like glial cell-derived neurotrophic factor (GDNF), neurotrophin nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and ciliary neurotrophic factor (CNTF) were found, suggesting that the activities reported in the literature are likely the result of new, hitherto unknown cryptic peptides with nootropic properties. Copyright © 2015 John Wiley & Sons, Ltd.

Hydrophilic interaction ultra-performance liquid chromatography coupled with triple-quadrupole tandem mass spectrometry for highly rapid and sensitive analysis of underivatized amino acids in functional foods.

PubMed

Zhou, Guisheng; Pang, Hanqing; Tang, Yuping; Yao, Xin; Mo, Xuan; Zhu, Shaoqing; Guo, Sheng; Qian, Dawei; Qian, Yefei; Su, Shulan; Zhang, Li; Jin, Chun; Qin, Yong; Duan, Jin-ao

2013-05-01

This work presented a new analytical methodology based on hydrophilic interaction ultra-performance liquid chromatography coupled with triple-quadrupole tandem mass spectrometry in multiple-reaction monitoring mode for analysis of 24 underivatized free amino acids (FAAs) in functional foods. The proposed method was first reported and validated by assessing the matrix effects, linearity, limit of detections and limit of quantifications, precision, repeatability, stability and recovery of all target compounds, and it was used to determine the nutritional substances of FAAs in ginkgo seeds and further elucidate the nutritional value of this functional food. The result showed that ginkgo seed turned out to be a good source of FAAs with high levels of several essential FAAs and to have a good nutritional value. Furthermore, the principal component analysis was performed to classify the ginkgo seed samples on the basis of 24 FAAs. As a result, the samples could be mainly clustered into three groups, which were similar to areas classification. Overall, the presented method would be useful for the investigation of amino acids in edible plants and agricultural products.

Testing the Binary Black Hole Nature of a Compact Binary Coalescence

NASA Astrophysics Data System (ADS)

Krishnendu, N. V.; Arun, K. G.; Mishra, Chandra Kant

2017-09-01

We propose a novel method to test the binary black hole nature of compact binaries detectable by gravitational wave (GW) interferometers and, hence, constrain the parameter space of other exotic compact objects. The spirit of the test lies in the "no-hair" conjecture for black holes where all properties of a Kerr black hole are characterized by its mass and spin. The method relies on observationally measuring the quadrupole moments of the compact binary constituents induced due to their spins. If the compact object is a Kerr black hole (BH), its quadrupole moment is expressible solely in terms of its mass and spin. Otherwise, the quadrupole moment can depend on additional parameters (such as the equation of state of the object). The higher order spin effects in phase and amplitude of a gravitational waveform, which explicitly contains the spin-induced quadrupole moments of compact objects, hence, uniquely encode the nature of the compact binary. Thus, we argue that an independent measurement of the spin-induced quadrupole moment of the compact binaries from GW observations can provide a unique way to distinguish binary BH systems from binaries consisting of exotic compact objects.

17O nuclear quadrupole coupling constants of water bound to a metal ion: A gadolinium(III) case study

NASA Astrophysics Data System (ADS)

Yazyev, Oleg V.; Helm, Lothar

2006-08-01

Rotational correlation times of metal ion aqua complexes can be determined from O17 NMR relaxation rates if the quadrupole coupling constant of the bound water oxygen-17 nucleus is known. The rotational correlation time is an important parameter for the efficiency of Gd3+ complexes as magnetic resonance imaging contrast agents. Using a combination of density functional theory with classical and Car-Parrinello molecular dynamics simulations we performed a computational study of the O17 quadrupole coupling constants in model aqua ions and the [Gd(DOTA)(H2O)]- complex used in clinical diagnostics. For the inner sphere water molecule in the [Gd(DOTA)(H2O)]- complex the determined quadrupole coupling parameter χ√1+η2/3 of 8.7MHz is very similar to that of the liquid water (9.0MHz ). Very close values were also predicted for the the homoleptic aqua ions of Gd3+ and Ca2+. We conclude that the O17 quadrupole coupling parameters of water molecules coordinated to closed shell and lanthanide metal ions are similar to water molecules in the liquid state.

Testing the Binary Black Hole Nature of a Compact Binary Coalescence.

PubMed

Krishnendu, N V; Arun, K G; Mishra, Chandra Kant

2017-09-01

We propose a novel method to test the binary black hole nature of compact binaries detectable by gravitational wave (GW) interferometers and, hence, constrain the parameter space of other exotic compact objects. The spirit of the test lies in the "no-hair" conjecture for black holes where all properties of a Kerr black hole are characterized by its mass and spin. The method relies on observationally measuring the quadrupole moments of the compact binary constituents induced due to their spins. If the compact object is a Kerr black hole (BH), its quadrupole moment is expressible solely in terms of its mass and spin. Otherwise, the quadrupole moment can depend on additional parameters (such as the equation of state of the object). The higher order spin effects in phase and amplitude of a gravitational waveform, which explicitly contains the spin-induced quadrupole moments of compact objects, hence, uniquely encode the nature of the compact binary. Thus, we argue that an independent measurement of the spin-induced quadrupole moment of the compact binaries from GW observations can provide a unique way to distinguish binary BH systems from binaries consisting of exotic compact objects.

Matter-wave solitons supported by quadrupole-quadrupole interactions and anisotropic discrete lattices

NASA Astrophysics Data System (ADS)

Zhong, Rong-Xuan; Huang, Nan; Li, Huang-Wu; He, He-Xiang; Lü, Jian-Tao; Huang, Chun-Qing; Chen, Zhao-Pin

2018-04-01

We numerically and analytically investigate the formations and features of two-dimensional discrete Bose-Einstein condensate solitons, which are constructed by quadrupole-quadrupole interactional particles trapped in the tunable anisotropic discrete optical lattices. The square optical lattices in the model can be formed by two pairs of interfering plane waves with different intensities. Two hopping rates of the particles in the orthogonal directions are different, which gives rise to a linear anisotropic system. We find that if all of the pairs of dipole and anti-dipole are perpendicular to the lattice panel and the line connecting the dipole and anti-dipole which compose the quadrupole is parallel to horizontal direction, both the linear anisotropy and the nonlocal nonlinear one can strongly influence the formations of the solitons. There exist three patterns of stable solitons, namely horizontal elongation quasi-one-dimensional discrete solitons, disk-shape isotropic pattern solitons and vertical elongation quasi-continuous solitons. We systematically demonstrate the relationships of chemical potential, size and shape of the soliton with its total norm and vertical hopping rate and analytically reveal the linear dispersion relation for quasi-one-dimensional discrete solitons.

Multiple shadows from distorted static black holes

NASA Astrophysics Data System (ADS)

Grover, Jai; Kunz, Jutta; Nedkova, Petya; Wittig, Alexander; Yazadjiev, Stoytcho

2018-04-01

We study the local shadow of the Schwarzschild black hole with a quadrupole distortion and the influence of the external gravitational field on the photon dynamics. The external matter sources modify the light ring structure and lead to the appearance of multiple shadow images. In the case of negative quadrupole moments we identify the most prominent mechanism causing multiple shadow formation. Furthermore, we obtain a condition under which this mechanism can be realized. This condition depends on the quadrupole moment, but also on the position of the observer and the celestial sphere.

The nuclear electric quadrupole moment of copper.

PubMed

Santiago, Régis Tadeu; Teodoro, Tiago Quevedo; Haiduke, Roberto Luiz Andrade

2014-06-21

The nuclear electric quadrupole moment (NQM) of the (63)Cu nucleus was determined from an indirect approach by combining accurate experimental nuclear quadrupole coupling constants (NQCCs) with relativistic Dirac-Coulomb coupled cluster calculations of the electric field gradient (EFG). The data obtained at the highest level of calculation, DC-CCSD-T, from 14 linear molecules containing the copper atom give rise to an indicated NQM of -198(10) mbarn. Such result slightly deviates from the previously accepted standard value given by the muonic method, -220(15) mbarn, although the error bars are superimposed.

Effect of deformations on the compactness of odd-Z superheavy nuclei formed in cold and hot fusion reactions

NASA Astrophysics Data System (ADS)

Kaur, Gurjit; Sandhu, Kirandeep; Sharma, Manoj K.

2018-03-01

Using the extended fragmentation theory, the compactness of hot and cold fusion reactions is analyzed for odd-Z nuclei ranging Z = 105- 117. The calculations for the present work are carried out at T = 0MeV and ℓ = 0 ħ, as the temperature and angular momentum effects remain silent while addressing the orientation degree of freedom (i.e. compact angle configuration). In the hot fusion, 48Ca (spherical) + actinide (prolate) reaction, the non-equatorial compact (nec) shape is obtained for Z = 113 nucleus. On the other hand, Z > 113 nuclei favor equatorial compact (ec) configuration. The distribution of barrier height (VB) illustrate that the ec-shape is obtained when the magnitude of quadrupole deformation of the nucleus is higher than the hexadecupole deformation. In other words, negligible or small -ve β4-deformations support ec configurations. On the other hand, large (+ve) magnitude of the β4-deformation suggests that the configuration appears for compact angle θc < 90 °, leading to nec structure. Similar deformation effects are observed for Bi-induced reactions, in which not belly-to-belly compact (nbbc) configurations are seen at θc = 42 °. In addition to the effect of β2 and β4-deformations, the exclusive role of octupole deformations (β3) is also analyzed. The β3-deformations do not follow the reflection symmetry as that of β2 and β4, leading to the possible occurrence of compact configuration within 0° to 180° angular range.

Ultracold molecules for the masses: Evaporative cooling and magneto-optical trapping

NASA Astrophysics Data System (ADS)

Stuhl, B. K.

While cold molecule experiments are rapidly moving towards their promised benefits of precision spectroscopy, controllable chemistry, and novel condensed phases, heretofore the field has been greatly limited by a lack of methods to cool and compress chemically diverse species to temperatures below ten millikelvin. While in atomic physics these needs are fulfilled by laser cooling, magneto-optical trapping, and evaporative cooling, until now none of these techniques have been applicable to molecules. In this thesis, two major breakthroughs are reported. The first is the observation of evaporative cooling in magnetically trapped hydroxyl (OH) radicals, which potentially opens a path all the way to Bose-Einstein condensation of dipolar radicals, as well as allowing cold- and ultracold-chemistry studies of fundamental reaction mechanisms. Through the combination of an extremely high gradient magnetic quadrupole trap and the use of the OH Λ-doublet transition to enable highly selective forced evaporation, cooling by an order of magnitude in temperature was achieved and yielded a final temperature no higher than 5mK. The second breakthrough is the successful application of laser cooling and magneto-optical trapping to molecules. Motivated by a proposal in this thesis, laser cooling of molecules is now known to be technically feasible in a select but substantial pool of diatomic molecules. The demonstration of not only Doppler cooling but also two-dimensional magneto-optical trapping in yttrium (II) oxide, YO, is expected to enable rapid growth in the availability of ultracold molecules—just as the invention of the atomic magneto-optical trap stimulated atomic physics twenty-five years ago.

Role of higher-multipole deformations in exotic {sup 14}C cluster radioactivity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sawhney, Gudveen; Sharma, Manoj K.; Gupta, Raj K.

2011-06-15

We have studied nine cases of spontaneous emission of {sup 14}C clusters in the ground-state decays of the same number of parent nuclei from the trans-lead region, specifically from {sup 221}Fr to {sup 226}Th, using the preformed cluster model (PCM) of Gupta and collaborators, with choices of spherical, quadrupole deformation ({beta}{sub 2}) alone, and higher-multipole deformations ({beta}{sub 2}, {beta}{sub 3}, {beta}{sub 4}) with cold ''compact'' orientations {theta}{sup c} of decay products. The calculated {sup 14}C cluster decay half-life times are found to be in nice agreement with experimental data only for the case of higher-multipole deformations ({beta}{sub 2}-{beta}{sub 4}) andmore » {theta}{sup c} orientations of cold elongated configurations. In other words, compared to our earlier study of clusters heavier than {sup 14}C, where the inclusion of {beta}{sub 2} alone, with ''optimum'' orientations, was found to be enough to give the best comparison with data, here for {sup 14}C cluster decay the inclusion of higher-multipole deformations (up to hexadecapole), together with {theta}{sup c} orientations, is found to be essential on the basis of the PCM. Interestingly, whereas both the penetration probability and assault frequency work simply as scaling factors, the preformation probability is strongly influenced by the order of multipole deformations and orientations of nuclei. The possible role of Q value and angular-momentum effects are also considered in reference to {sup 14}C cluster radioactivity.« less

A dark-line two-dimensional magneto-optical trap of 85Rb atoms with high optical depth.

PubMed

Zhang, Shanchao; Chen, J F; Liu, Chang; Zhou, Shuyu; Loy, M M T; Wong, G K L; Du, Shengwang

2012-07-01

We describe the apparatus of a dark-line two-dimensional (2D) magneto-optical trap (MOT) of (85)Rb cold atoms with high optical depth (OD). Different from the conventional configuration, two (of three) pairs of trapping laser beams in our 2D MOT setup do not follow the symmetry axes of the quadrupole magnetic field: they are aligned with 45° angles to the longitudinal axis. Two orthogonal repumping laser beams have a dark-line volume in the longitudinal axis at their cross over. With a total trapping laser power of 40 mW and repumping laser power of 18 mW, we obtain an atomic OD up to 160 in an electromagnetically induced transparency (EIT) scheme, which corresponds to an atomic-density-length product NL = 2.05 × 10(15) m(-2). In a closed two-state system, the OD can become as large as more than 600. Our 2D MOT configuration allows full optical access of the atoms in its longitudinal direction without interfering with the trapping and repumping laser beams spatially. Moreover, the zero magnetic field along the longitudinal axis allows the cold atoms maintain a long ground-state coherence time without switching off the MOT magnetic field, which makes it possible to operate the MOT at a high repetition rate and a high duty cycle. Our 2D MOT is ideal for atomic-ensemble-based quantum optics applications, such as EIT, entangled photon pair generation, optical quantum memory, and quantum information processing.

Conductor Specification and Validation for High-Luminosity LHC Quadrupole Magnets

DOE PAGES

Cooley, L. D.; Ghosh, A. K.; Dietderich, D. R.; ...

2017-06-01

The High Luminosity Upgrade of the Large Hadron Collider (HL-LHC) at CERN will replace the main ring inner triplet quadrupoles, identified by the acronym MQXF, adjacent to the main ring intersection regions. For the past decade, the U.S. LHC Accelerator R&D Program, LARP, has been evaluating conductors for the MQXFA prototypes, which are the outer magnets of the triplet. Recently, the requirements for MQXF magnets and cables have been published in P. Ferracin et al., IEEE Trans. Appl. Supercond., vol. 26, no. 4, 2016, Art. no.4000207, along with the final specification for Ti-alloyed Nb3Sn conductor determined jointly by CERN andmore » LARP. This paper describes the rationale beneath the 0.85 mm diameter strand’s chief parameters, which are 108 or more sub-elements, a copper fraction not less than 52.4%, strand critical current at 4.22 K not less than 631 A at 12 T and 331 A at 15 T, and residual resistance ratio of not less than 150. This paper also compares the performance for ~100 km production lots of the five most recent LARP conductors to the first 163 km of strand made according to the HL-LHC specification. Two factors emerge as significant for optimizing performance and minimizing risk: a modest increase of the sub-element diameter from 50 to 55 μm, and a Nb:Sn molar ratio of 3.6 instead of 3.4. Furthermore, the statistics acquired so far give confidence that the present conductor can balance competing demands in production for the HL-LHC project.« less

A Superstrong Adjustable Permanent Magnet for the Final Focus Quadrupole in a Linear Collider

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mihara, T.

A super strong permanent magnet quadrupole (PMQ) was fabricated and tested. It has an integrated strength of 28.5T with overall length of 10 cm and a 7mm bore radius. The final focus quadrupole of a linear collider needs a variable focal length. This can be obtained by slicing the magnet into pieces along the beamline direction and rotating these slices. But this technique may lead to movement of the magnetic center and introduction of a skew quadrupole component when the strength is varied. A ''double ring structure'' can ease these effects. A second prototype PMQ, containing thermal compensation materials andmore » with a double ring structure, has been fabricated. Worm gear is selected as the mechanical rotating scheme because the double ring structure needs a large torque to rotate magnets. The structure of the second prototype PMQ is shown.« less

Study of a micro chamber quadrupole mass spectrometer

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang Jinchan; Zhang Xiaobing; Mao Fuming

The design of a micro chamber quadrupole mass spectrometer (MCQMS) having a small total volume of only 20 cm{sup 3}, including Faraday cup ion detector and ion source, is described. This MCQMS can resist a vacuum baking temperature of 400-500 deg. C. The quadrupole elements with a hyperbolic surface are made of a ceramic material and coated with a thin metal layer. The quadrupole mass filter has a field radius of 3 mm and a length of 100 mm. Prototypes of this new MCQMS can detect a minimum partial pressure of 10{sup -8} Pa, have a peak width of {delta}M=1more » at 10% peak height from mass number 1 to 60, and show an excellent long-term stability. The new MCQMS is intended to be used in residual gas analyses of electron devices during a mutual pumping and baking process.« less

Mass peak shape improvement of a quadrupole mass filter when operating with a rectangular wave power supply.

PubMed

Luo, Chan; Jiang, Dan; Ding, Chuan-Fan; Konenkov, Nikolai V

2009-09-01

Numeric experiments were performed to study the first and second stability regions and find the optimal configurations of a quadrupole mass filter constructed of circular quadrupole rods with a rectangular wave power supply. The ion transmission contours were calculated using ion trajectory simulations. For the first stability region, the optimal rod set configuration and the ratio r/r(0) is 1.110-1.115; for the second stability region, it is 1.128-1.130. Low-frequency direct current (DC) modulation with the parameters of m = 0.04-0.16 and nu = omega/Omega = 1/8-1/14 improves the mass peak shape of the circular rod quadrupole mass filter at the optimal r/r(0) ratio of 1.130. The amplitude modulation does not improve mass peak shape. Copyright (c) 2009 John Wiley & Sons, Ltd.

Development of a GC/Quadrupole-Orbitrap Mass Spectrometer, Part I: Design and Characterization

PubMed Central

2015-01-01

Identification of unknown compounds is of critical importance in GC/MS applications (metabolomics, environmental toxin identification, sports doping, petroleomics, and biofuel analysis, among many others) and remains a technological challenge. Derivation of elemental composition is the first step to determining the identity of an unknown compound by MS, for which high accuracy mass and isotopomer distribution measurements are critical. Here, we report on the development of a dedicated, applications-grade GC/MS employing an Orbitrap mass analyzer, the GC/Quadrupole-Orbitrap. Built from the basis of the benchtop Orbitrap LC/MS, the GC/Quadrupole-Orbitrap maintains the performance characteristics of the Orbitrap, enables quadrupole-based isolation for sensitive analyte detection, and includes numerous analysis modalities to facilitate structural elucidation. We detail the design and construction of the instrument, discuss its key figures-of-merit, and demonstrate its performance for the characterization of unknown compounds and environmental toxins. PMID:25208235

Microfluidic quadrupole and floating concentration gradient.

PubMed

Qasaimeh, Mohammad A; Gervais, Thomas; Juncker, David

2011-09-06

The concept of fluidic multipoles, in analogy to electrostatics, has long been known as a particular class of solutions of the Navier-Stokes equation in potential flows; however, experimental observations of fluidic multipoles and of their characteristics have not been reported yet. Here we present a two-dimensional microfluidic quadrupole and a theoretical analysis consistent with the experimental observations. The microfluidic quadrupole was formed by simultaneously injecting and aspirating fluids from two pairs of opposing apertures in a narrow gap formed between a microfluidic probe and a substrate. A stagnation point was formed at the centre of the microfluidic quadrupole, and its position could be rapidly adjusted hydrodynamically. Following the injection of a solute through one of the poles, a stationary, tunable, and movable-that is, 'floating'-concentration gradient was formed at the stagnation point. Our results lay the foundation for future combined experimental and theoretical exploration of microfluidic planar multipoles including convective-diffusive phenomena.

Reconstruction of CMB temperature anisotropies with primordial CMB induced polarization in galaxy clusters

NASA Astrophysics Data System (ADS)

Liu, Guo-Chin; Ichiki, Kiyotomo; Tashiro, Hiroyuki; Sugiyama, Naoshi

2016-07-01

Scattering of cosmic microwave background (CMB) radiation in galaxy clusters induces polarization signals determined by the quadrupole anisotropy in the photon distribution at the location of clusters. This `remote quadrupole' derived from the measurements of the induced polarization in galaxy clusters provides an opportunity to reconstruct local CMB temperature anisotropies. In this Letter, we develop an algorithm of the reconstruction through the estimation of the underlying primordial gravitational potential, which is the origin of the CMB temperature and polarization fluctuations and CMB induced polarization in galaxy clusters. We found a nice reconstruction for the quadrupole and octopole components of the CMB temperature anisotropies with the assistance of the CMB induced polarization signals. The reconstruction can be an important consistency test on the puzzles of CMB anomalies, especially for the low-quadrupole and axis-of-evil problems reported in Wilkinson Microwave Anisotropy Probe and Planck data.

Physical origin of the quadrupole out-of-plane magnetic field in Hall-magnetohydrodynamic reconnection

DOE Office of Scientific and Technical Information (OSTI.GOV)

Uzdensky, Dmitri A.; Kulsrud, Russell M.

2006-06-15

A quadrupole pattern of the out-of-plane component of the magnetic field inside a reconnection region is seen as an important signature of the Hall-magnetohydrodynamic regime of reconnection. It has been first observed in numerical simulations and just recently confirmed in the Magnetic Reconnection Experiment [Y. Ren, M. Yamada, S. Gerhardt, H. Ji, R. Kulsrud, and A. Kuritsin, Phys. Rev. Lett. 95, 055003 (2005)] and also seen in spacecraft observations of Earth's magnetosphere. In this study, the physical origin of the quadrupole field is analyzed and traced to a current of electrons that flows along the lines in and out ofmore » the inner reconnection region to maintain charge neutrality. The role of the quadrupole magnetic field in the overall dynamics of the reconnection process is discussed. In addition, the bipolar poloidal electric field is estimated and its effect on ion motions is emphasized.« less

8. FIRST FLOOR INTERIOR, ONE OF THREE MAIN REFRIGERATIONFREEZER ROOMS ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

8. FIRST FLOOR INTERIOR, ONE OF THREE MAIN REFRIGERATION-FREEZER ROOMS (NO. 4), FROM CENTRAL CORRIDOR OPPOSITE ENTRANCE, LOOKING WEST. - Oakland Naval Supply Center, Cold Storage Warehouse, South of C Street between First & Second Street, Oakland, Alameda County, CA

Cold periods and coronary events: an analysis of populations worldwide

PubMed Central

Barnett, A.; Dobson, A.; McElduff, P.; Salomaa, V.; Kuulasmaa, K.; Sans, S.; t for

2005-01-01

Study objective: To investigate the association between cold periods and coronary events, and the extent to which climate, sex, age, and previous cardiac history increase risk during cold weather. Design: A hierarchical analyses of populations from the World Health Organisation's MONICA project. Setting: Twenty four populations from the WHO's MONICA project, a 21 country register made between 1980 and 1995. Patients: People aged 35–64 years who had a coronary event. Main results: Daily rates of coronary events were correlated with the average temperature over the current and previous three days. In cold periods, coronary event rates increased more in populations living in warm climates than in populations living in cold climates, where the increases were slight. The increase was greater in women than in men, especially in warm climates. On average, the odds for women having an event in the cold periods were 1.07 higher than the odds for men (95% posterior interval: 1.03 to 1.11). The effects of cold periods were similar in those with and without a history of a previous myocardial infarction. Conclusions: Rates of coronary events increased during comparatively cold periods, especially in warm climates. The smaller increases in colder climates suggest that some events in warmer climates are preventable. It is suggested that people living in warm climates, particularly women, should keep warm on cold days. PMID:15965137

Responses of sympathetic nervous system to cold exposure in vibration syndrome subjects and age-matched healthy controls.

PubMed

Nakamoto, M

1990-01-01

Plasma norepinephrine and epinephrine in vibration syndrome subjects and age-matched healthy controls were measured for the purpose of estimating the responsibility of the sympathetic nervous system to cold exposure. In preliminary experiment, it was confirmed that cold air exposure of the whole body was more suitable than one-hand immersion in cold water. In the main experiment, 195 subjects were examined. Sixty-five subjects had vibration syndrome with vibration-induced white finger (VWF + group) and 65 subjects had vibration syndrome without VWF (VWF- group) and 65 controls had no symptoms (control group). In the three groups, plasma norepinephrine levels increased during cold air exposure of whole body at 7 degrees +/- 1.5 degrees C. Blood pressure increased and skin temperature decreased during cold exposure. Percent increase of norepinephrine in the VWF+ group was the highest while that in VWF- group followed and that in the control group was the lowest. This whole-body response of the sympathetic nervous system to cold conditions reflected the VWF which are characteristic symptoms of vibration syndrome. Excluding the effects of shivering and a cold feeling under cold conditions, it was confirmed that the sympathetic nervous system in vibration syndrome is activated more than in the controls. These results suggest that vibration exposure to hand and arm affects the sympathetic nervous system.

Gene analysis and structure prediction for the cold-adaption mechanism of trypsin from the krill Euphausia superba (Dana, 1852).

PubMed

Zhou, Tingting; Wang, Xichang; Yan, Juan; Li, Yan

2018-06-01

The ability of Antarctic krill, Euphausia superba (Dana, 1852), to thrive in a cold environment comes from its capacity to synthesize cold-adapted enzymes. Its trypsin, as a main substance in the metabolic reactions, plays a key role in the adaption to low temperatures. However, the progress of research on its cold-adaption mechanism is being influenced due to the limited information on its gene and spatial structure. We studied the gene of E. superba trypsin with transcriptome sequencing first, and then discussed its cold-adaption mechanism with the full gene and predicted structure basing on bioinformatics. The results showed the proportion of certain residues played important roles in the cold-adaptation behavior for trypsin. Furthermore, a higher proportion of random coils and reduced steric hindrance might also be key factors promoting its cold adaption. This research aimed to reveal the cold-adaption mechanism of E. superba trypsin and provide support for basic research on molecular modification by site-directed mutagenesis of complementary DNA used to produce new and improved recombinant variants with cold adaption. Furthermore, it may broaden its commercial application on minimizing undesirable changes elevated at higher temperature in food processing and in treatment of trauma and inflammation in medicine. © 2017 Society of Chemical Industry. © 2017 Society of Chemical Industry.

Nitric Acid Particles in Cold Thick Ice Clouds Observed at Global Scale: Link with Lightning, Temperature, and Upper Tropospheric Water Vapor

NASA Technical Reports Server (NTRS)

Chepfer, H.; Minnis, P.; Dubuisson, P.; Chiriaco, M.; Sun-Mack, S.; Riviere, E. D.

2007-01-01

Signatures of nitric acid particles (NAP) in cold thick ice clouds have been derived from satellite observations. Most NAP are detected in the Tropics (9 to 20% of clouds with T less than 202.5 K). Higher occurrences were found in the rare mid-latitudes very cold clouds. NAP occurrence increases as cloud temperature decreases and NAP are more numerous in January than July. Comparisons of NAP and lightning distributions show that lightning is the main source of the NOx, which forms NAP in cold clouds. Qualitative comparisons of NAP with upper tropospheric humidity distributions suggest that NAP play a role in the dehydration of the upper troposphere when the tropopause is colder than 195K.

Nitric acid particles in cold thick ice clouds observed at global scale: Link with lightning, temperature, and upper tropospheric water vapor

NASA Astrophysics Data System (ADS)

Chepfer, H.; Minnis, P.; Dubuisson, P.; Chiriaco, M.; Sun-Mack, S.; RivièRe, E. D.

2007-03-01

Signatures of nitric acid particles (NAP) in cold thick ice clouds have been derived from satellite observations. Most NAP are detected in the tropics (9 to 20% of clouds with T < 202.5 K). Higher occurrences were found in the rare midlatitudes very cold clouds. NAP occurrence increases as cloud temperature decreases, and NAP are more numerous in January than July. Comparisons of NAP and lightning distributions show that lightning seems to be the main source of the NOx, which forms NAP in cold clouds over continents. Qualitative comparisons of NAP with upper tropospheric humidity distributions suggest that NAP may play a role in the dehydration of the upper troposphere when the tropopause is colder than 195 K.

[Analytic study of juices obtained by pressure, by cold extraction and warm extraction (the DDS system) of marc from apples of the Golden Delicious variety].

PubMed

Tanner, H

1978-01-01

The cold water extraction of apple press residues to increase the juice yield has found much interest in recent years. Such a process has been developed by a Swiss company, but the food legislation does not permit it yet. Juice yield is increased up to 91 p. 100 (w.). Therefore we investigated the chemical and sensorical properties of pressed juice, cold water extract of press residues and warm water extract (System DDS) of identical raw material. The water extract differs from the pressed juice mainly by an increased amount of non-sugar extract and changes of the pigment and polyphenole content. The cold water extract had more and the better aroma than the warm extract.

Thermal Management of a Nitrogen Cryogenic Loop Heat Pipe

NASA Astrophysics Data System (ADS)

Gully, Ph.; Yan, T.

2010-04-01

Efficient thermal links are needed to ease the distribution of the cold power in satellites. Loop heat pipes are widely used at room temperature as passive thermal links based on a two-phase flow generated by capillary forces. Transportation of the cold power at cryogenic temperatures requires a specific design. In addition to the main loop, the cryogenic loop heat pipe (CLHP) features a hot reservoir and a secondary loop with a cold reservoir and a secondary evaporator which allows the cool down and the thermal management of the thermal link in normal cold operation. We have studied the influence of a heated cold reservoir and investigated the effect of parasitic heat loads on the performance of a nitrogen CLHP at around 80 K. It is shown that heating of the cold reservoir with a small amount of power (0.1 W) allows controlling the system temperature difference, which can be kept constant at a very low level (1 K) regardless of the transferred cold power (0-10 W). Parasitic heat loads have a significant effect on the thermal resistance, and the power applied on the secondary evaporator has to be increased up to 4 W to get stable operation.

Using cold air for reducing needle-injection pain.

PubMed

Al-Qarqaz, Firas; Al-Aboosi, Mustafa; Al-shiyab, Diala; Al Dabbagh, Ziad

2012-07-01

Pain is associated with skin injections. Reducing injection-associated pain is important especially when multiple injections are needed in difficult areas, such as the palms. We present a new safe application for cold air used in laser therapy. The main objectives of this study are to see whether cold air can reduce needle-injection pain and to evaluate the safety of this new application. Patients undergoing skin injection (n=40) were included. Assessment of pain level using visual analog scale (VAS) was done using cold air and again without cold air in the same patient. Comparison of pain scores was performed. Thirty-three patients had lower VAS scores using cold air. Five patients had worse VAS scores, and two patients did not have any change in their pain score. In the group of patients where injections were made to the palms (n=5), there was even more reduction in VAS scores. There were no significant immediate or delayed side effects. Cold air seems to be useful in reducing needle-injection pain in the majority of patients, especially in the palms. This procedure is safe, apart from immediate tolerable discomfort when used around the nose. © 2012 The International Society of Dermatology.

Experimentally Identify the Effective Plume Chimney over a Natural Draft Chimney Model

NASA Astrophysics Data System (ADS)

Rahman, M. M.; Chu, C. M.; Tahir, A. M.; Ismail, M. A. bin; Misran, M. S. bin; Ling, L. S.

2017-07-01

The demands of energy are in increasing order due to rapid industrialization and urbanization. The researchers and scientists are working hard to improve the performance of the industry so that the energy consumption can be reduced significantly. Industries like power plant, timber processing plant, oil refinery, etc. performance mainly depend on the cooling tower chimney’s performance, either natural draft or forced draft. Chimney is used to create sufficient draft, so that air can flow through it. Cold inflow or flow reversal at chimney exit is one of the main identified problems that may alter the overall plant performance. The presence Effective Plume Chimney (EPC) is an indication of cold inflow free operation of natural draft chimney. Different mathematical model equations are used to estimate the EPC height over the heat exchanger or hot surface. In this paper, it is aim to identify the EPC experimentally. In order to do that, horizontal temperature profiling is done at the exit of the chimneys of face area 0.56m2, 1.00m2 and 2.25m2. A wire mesh screen is installed at chimneys exit to ensure cold inflow chimney operation. It is found that EPC exists in all modified chimney models and the heights of EPC varied from 1 cm to 9 cm. The mathematical models indicate that the estimated heights of EPC varied from 1 cm to 2.3 cm. Smoke test is also conducted to ensure the existence of EPC and cold inflow free option of chimney. Smoke test results confirmed the presence of EPC and cold inflow free operation of chimney. The performance of the cold inflow free chimney is increased by 50% to 90% than normal chimney.

LADEE Propulsion System Cold Flow Test

NASA Technical Reports Server (NTRS)

Williams, Jonathan Hunter; Chapman, Jack M.; Trinh, Hau, P.; Bell, James H.

2013-01-01

Lunar Atmosphere and Dust Environment Explorer (LADEE) is a NASA mission that will orbit the Moon. Its main objective is to characterize the atmosphere and lunar dust environment. The spacecraft development is being led by NASA Ames Research Center and scheduled for launch in 2013. The LADEE spacecraft will be operated with a bi-propellant hypergolic propulsion system using MMH and NTO as the fuel and oxidizer, respectively. The propulsion system utilizes flight-proven hardware on major components. The propulsion layout is composed of one 100-lbf main thruster and four 5-lbf RCS thrusters. The propellants are stored in four tanks (two parallel-connected tanks per propellant component). The propellants will be pressurized by regulated helium. A simulated propulsion system has been built for conducting cold flow test series to characterize the transient fluid flow of the propulsion system feed lines and to verify the critical operation modes, such as system priming, waterhammer, and crucial mission duty cycles. Propellant drainage differential between propellant tanks will also be assessed. Since the oxidizer feed line system has a higher flow demand than the fuel system does, the cold flow test focuses on the oxidizer system. The objective of the cold flow test is to simulate the LADEE propulsion fluid flow operation through water cold flow test and to obtain data for anchoring analytical models. The models will be used to predict the transient and steady state flow behaviors in the actual flight operations. The test activities, including the simulated propulsion test article, cold flow test, and analytical modeling, are being performed at NASA Marshall Space Flight Center. At the time of the abstract submission, the test article checkout is being performed. The test series will be completed by November, 2012

Open-cycle systems performance analysis programming guide

DOE Office of Scientific and Technical Information (OSTI.GOV)

Olson, D.A.

1981-12-01

The Open-Cycle OTEC Systems Performance Analysis Program is an algorithm programmed on SERI's CDC Cyber 170/720 computer to predict the performance of a Claude-cycle, open-cycle OTEC plant. The algorithm models the Claude-cycle system as consisting of an evaporator, a turbine, a condenser, deaerators, a condenser gas exhaust, a cold water pipe and cold and warm seawater pumps. Each component is a separate subroutine in the main program. A description is given of how to write Fortran subroutines to fit into the main program for the components of the OTEC plant. An explanation is provided of how to use the algorithm.more » The main program and existing component subroutines are described. Appropriate common blocks and input and output variables are listed. Preprogrammed thermodynamic property functions for steam, fresh water, and seawater are described.« less

A comprehensive review on cold work of AISI D2 tool steel

NASA Astrophysics Data System (ADS)

Abdul Rahim, Mohd Aidil Shah bin; Minhat, Mohamad bin; Hussein, Nur Izan Syahriah Binti; Salleh, Mohd Shukor bin

2017-11-01

As a common material in mould and die application, AISI D2 cold work tool steel has proven to be a promising chosen material in the industries. However, challenges remain in using AISI D2 through a modified version with a considerable progress having been made in recent years. This paper provides a critical review of the original as-cast AISI D2 cold work tool steel up to the modified version. The main purpose is to develop an understanding of current modified tool steel trend; the machinability of AISI D2 (drilling, milling, turning, grinding and EDM/WEDM; and the microstructure evolution and mechanical properties of these cold work tool steels due to the presence of alloy materials in the steel matrix. The doping of rare earth alloy element, new steel fabrication processes, significant process parameter in machinability and surface treatment shows that there have been few empirical investigations into these cold work tool steel alloys. This study has discovered that cold work tool steel will remain to be explored in order to survive in the steel industries.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Owen, Benjamin C.; Kenttamaa, Hilkka I.

The present disclosure provides a new tandem mass spectrometer and methods of using the same for analyzing charged particles. The differentially pumped dual linear quadrupole ion trap mass spectrometer of the present disclose includes a combination of two linear quadrupole (LQIT) mass spectrometers with differentially pumped vacuum chambers.

The nuclear electric quadrupole moment of antimony from the molecular method.

PubMed

Haiduke, Roberto L A; da Silva, Albérico B F; Visscher, Lucas

2006-08-14

Relativistic Dirac-Coulomb (DC) Hartree-Fock calculations are employed to obtain the analytic electric field gradient (EFG) on the antimony nucleus in the SbN, SbP, SbF, and SbCl molecules. The electronic correlation contribution to the EFGs is included with the DC-CCSD(T) and DC-CCSD-T approaches, also in the four-component framework, using a finite-difference method. The total EFG results, along with the experimental nuclear quadrupole coupling constants from microwave spectroscopy, allow to derive the nuclear quadrupole moments of (121)Sb and (123)Sb, respectively, as -543(11) and -692(14) mb.

Method and apparatus for measuring the gas permeability of a solid sample

DOEpatents

Carstens, D.H.W.

1984-01-27

The disclosure is directed to an apparatus and method for measuring the permeability of a gas in a sample. The gas is allowed to reach a steady flow rate through the sample. A measurable amount of the gas is collected during a given time period and then delivered to a sensitive quadrupole. The quadrupole signal, adjusted for background, is proportional to the amount of gas collected during the time period. The quadrupole can be calibrated with a standard helium leak. The gas can be deuterium and the sample can be polyvinyl alcohol.

Charge Dependence and Electric Quadrupole Effects on Single-Nucleon Removal in Relativistic and Intermediate Energy Nuclear Collisions

NASA Technical Reports Server (NTRS)

Norbury, John W.

1992-01-01

Single nucleon removal in relativistic and intermediate energy nucleus-nucleus collisions is studied using a generalization of Weizsacker-Williams theory that treats each electromagnetic multipole separately. Calculations are presented for electric dipole and quadrupole excitations and incorporate a realistic minimum impact parameter, Coulomb recoil corrections, and the uncertainties in the input photonuclear data. Discrepancies are discussed. The maximum quadrupole effect to be observed in future experiments is estimated and also an analysis of the charge dependence of the electromagnetic cross sections down to energies as low as 100 MeV/nucleon is made.

Charge dependence and electric quadrupole effects on single-nucleon removal in relativistic and intermediate energy nuclear collisions

NASA Technical Reports Server (NTRS)

Norbury, J. W.; Townsend, L. W. (Principal Investigator)

1990-01-01

Single-nucleon removal in relativistic and intermediate energy nucleus-nucleus collisions is studied using a generalization of Weizsacker-Williams theory that treats each electromagnetic multipole separately. Calculations are presented for electric dipole and quadrupole excitations and incorporate a realistic minimum impact parameter, Coulomb recoil corrections, and the uncertainties in the input photonuclear data. Discrepancies are discussed. The maximum quadrupole effect to be observed in future experiments is estimated and also an analysis of the charge dependence of the electromagnetic cross sections down to energies as low as 100 MeV/nucleon is made.

Electron cloud generation and trapping in a quadrupole magnet at the Los Alamos proton storage ring

NASA Astrophysics Data System (ADS)

Macek, Robert J.; Browman, Andrew A.; Ledford, John E.; Borden, Michael J.; O'Hara, James F.; McCrady, Rodney C.; Rybarcyk, Lawrence J.; Spickermann, Thomas; Zaugg, Thomas J.; Pivi, Mauro T. F.

2008-01-01

Recent beam physics studies on the two-stream e-p instability at the LANL proton storage ring (PSR) have focused on the role of the electron cloud generated in quadrupole magnets where primary electrons, which seed beam-induced multipacting, are expected to be largest due to grazing angle losses from the beam halo. A new diagnostic to measure electron cloud formation and trapping in a quadrupole magnet has been developed, installed, and successfully tested at PSR. Beam studies using this diagnostic show that the “prompt” electron flux striking the wall in a quadrupole is comparable to the prompt signal in the adjacent drift space. In addition, the “swept” electron signal, obtained using the sweeping feature of the diagnostic after the beam was extracted from the ring, was larger than expected and decayed slowly with an exponential time constant of 50 to 100μs. Other measurements include the cumulative energy spectra of prompt electrons and the variation of both prompt and swept electron signals with beam intensity. Experimental results were also obtained which suggest that a good fraction of the electrons observed in the adjacent drift space for the typical beam conditions in the 2006 run cycle were seeded by electrons ejected from the quadrupole.

Tuneable complementary metamaterial structures based on graphene for single and multiple transparency windows

PubMed Central

Ding, Jun; Arigong, Bayaner; Ren, Han; Zhou, Mi; Shao, Jin; Lu, Meng; Chai, Yang; Lin, Yuankun; Zhang, Hualiang

2014-01-01

Novel graphene-based tunable plasmonic metamaterials featuring single and multiple transparency windows are numerically studied in this paper. The designed structures consist of a graphene layer perforated with quadrupole slot structures and dolmen-like slot structures printed on a substrate. Specifically, the graphene-based quadrupole slot structure can realize a single transparency window, which is achieved without breaking the structure symmetry. Further investigations have shown that the single transparency window in the proposed quadrupole slot structure is more likely originated from the quantum effect of Autler-Townes splitting. Then, by introducing a dipole slot to the quadrupole slot structure to form the dolmen-like slot structure, an additional transmission dip could occur in the transmission spectrum, thus, a multiple-transparency-window system can be achieved (for the first time for graphene-based devices). More importantly, the transparency windows for both the quadrupole slot and the dolmen-like slot structures can be dynamically controlled over a broad frequency range by varying the Fermi energy levels of the graphene layer (through electrostatic gating). The proposed slot metamaterial structures with tunable single and multiple transparency windows could find potential applications in many areas such as multiple-wavelength slow-light devices, active plasmonic switching, and optical sensing. PMID:25146672

Tuneable complementary metamaterial structures based on graphene for single and multiple transparency windows.

PubMed

Ding, Jun; Arigong, Bayaner; Ren, Han; Zhou, Mi; Shao, Jin; Lu, Meng; Chai, Yang; Lin, Yuankun; Zhang, Hualiang

2014-08-22

Novel graphene-based tunable plasmonic metamaterials featuring single and multiple transparency windows are numerically studied in this paper. The designed structures consist of a graphene layer perforated with quadrupole slot structures and dolmen-like slot structures printed on a substrate. Specifically, the graphene-based quadrupole slot structure can realize a single transparency window, which is achieved without breaking the structure symmetry. Further investigations have shown that the single transparency window in the proposed quadrupole slot structure is more likely originated from the quantum effect of Autler-Townes splitting. Then, by introducing a dipole slot to the quadrupole slot structure to form the dolmen-like slot structure, an additional transmission dip could occur in the transmission spectrum, thus, a multiple-transparency-window system can be achieved (for the first time for graphene-based devices). More importantly, the transparency windows for both the quadrupole slot and the dolmen-like slot structures can be dynamically controlled over a broad frequency range by varying the Fermi energy levels of the graphene layer (through electrostatic gating). The proposed slot metamaterial structures with tunable single and multiple transparency windows could find potential applications in many areas such as multiple-wavelength slow-light devices, active plasmonic switching, and optical sensing.

Electrostatic Properties of Aqueous Salt Solution Interfaces: A Comparison of Polarizable and Non-Polarizable Ion Models

PubMed Central

Warren, G. Lee; Patel, Sandeep

2014-01-01

The effects of ion force field polarizability on the interfacial electrostatic properties of ~1 M aqueous solutions of NaCl, CsCl and NaI are investigated using molecular dynamics simulations employing both non-polarizable and Drude-polarizable ion sets. Differences in computed depth-dependent orientational distributions, “permanent” and induced dipole and quadrupole moment profiles, and interfacial potentials are obtained for both ion sets to further elucidate how ion polarizability affects interfacial electrostatic properties among the various salts relative to pure water. We observe that the orientations and induced dipoles of water molecules are more strongly perturbed in the presence of polarizable ions via a stronger ionic double layer effect arising from greater charge separation. Both anions and cations exhibit enhanced induced dipole moments and strong z alignment in the vicinity of the Gibbs dividing surface (GDS) with the magnitude of the anion induced dipoles being nearly an order of magnitude larger than those of the cations and directed into the vapor phase. Depth-dependent profiles for the trace and zz components of the water molecular quadrupole moment tensors reveal 40% larger quadrupole moments in the bulk phase relative to the vapor mimicking a similar observed 40% increase in the average water dipole moment. Across the GDS, the water molecular quadrupole moments increase non-monotonically (in contrast to the water dipoles) and exhibit a locally reduced contribution just below the surface due to both orientational and polarization effects. Computed interfacial potentials for the non-polarizable salts yield values 20 to 60 mV more positive than pure water and increase by an additional 30 to 100 mV when ion polarizability is included. A rigorous decomposition of the total interfacial potential into ion monopole, water and ion dipole, and water quadrupole components reveals that a very strong, positive ion monopole contribution is offset by negative contributions from all other potential sources. Water quadrupole components modulated by the water density contribute significantly to the observed interfacial potential increments and almost entirely explain observed differences in the interfacial potentials for the two chloride salts. By lumping all remaining non-quadrupole interfacial potential contributions into a single “effective” dipole potential, we observe that the ratio of quadrupole to “effective” dipole contributions range from 2:1 in CsCl to 1:1.5 in NaI suggesting that both contributions are comparably important in determining the interfacial potential increments. We also find that oscillations in the quadrupole potential in the double layer region are opposite in sign and partially cancel those of the “effective” dipole potential. PMID:18712908

Screening for in vitro metabolites of kakkalide and irisolidone in human and rat intestinal bacteria by ultra-high performance liquid chromatography/quadrupole time-of-flight mass spectrometry.

PubMed

Zhang, Guozhe; Gong, Tianxing; Kano, Yoshihiro; Yuan, Dan

2014-02-01

Kakkalide and irisolidone, the main isoflavones of Flos Puerariae, exhibit a wide spectrum of bioactivities. Intestinal bacteria biotransformation plays an important role in the metabolic pathways of flavones, and is directly related to the bioactivities of the prodrugs after oral administration. To the best of our knowledge, the metabolic pathways of kakkalide and irisolidone in vitro have not been comprehensively studied yet. This paper describes the strategy using ultra-high performance liquid chromatography/quadrupole time-of-flight mass spectrometry (UHPLC/Q-TOF MS) for the rapid analysis of the metabolic profiles of kakkalide and irisolidone after incubated with human and rat intestinal bacteria. Bacteria incubated samples were prepared and analyzed after incubated under anaerobic conditions for 48 h. A total of 17 metabolites, including parent compounds, were detected in human and rat intestinal bacteria incubated samples. The results obtained indicate that hydrolysis, dehydroxylation, demethoxylation, demethylation, hydroxylation, decarbonylation, and reduction were the detected metabolic pathways of kakkalide and irisolidone in vitro. The conversion rate of irisolidone in human and rat bacteria was 8.57% and 6.51%, respectively. Biochanin A was the relatively main metabolite of irisolidone, and the content of biochanin A in human and rat bacteria was 3.68% and 4.25%, respectively. The conversion rate of kakkalide in human and rat bacteria was 99.92% and 98.58%, respectively. Irisolidone was the main metabolite of kakkalide, and the content of irisolidone in human and rat bacteria was 89.58% and 89.38%, respectively. This work not only provides the evidence of kakkalide and irisolidone metabolites in vivo, but also demonstrates a simple, fast, sensitive, and inexpensive method for identification of metabolites of other compounds transformed by intestinal bacteria. Copyright © 2013 Elsevier B.V. All rights reserved.

Comparison of the toxicities, activities and chemical profiles of raw and processed Xanthii Fructus.

PubMed

Su, Tao; Cheng, Brian Chi-Yan; Fu, Xiu-Qiong; Li, Ting; Guo, Hui; Cao, Hui-Hui; Kwan, Hiu-Yee; Tse, Anfernee Kai-Wing; Yu, Hua; Cao, Hui; Yu, Zhi-Ling

2016-01-22

Although toxic, the Chinese medicinal herb Xanthii Fructus (XF) is commonly used to treat traditional Chinese medicine (TCM) symptoms that resemble cold, sinusitis and arthritis. According to TCM theory, stir-baking (a processing method) can reduce the toxicity and enhance the efficacy of XF. Cytotoxicities of raw XF and processed XF (stir-baked XF, SBXF) were determined by the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay in normal liver derived MIHA cells. Nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) mRNA expression were measured by the Griess reagent and quantitative real-time PCR, respectively. The chemical profiles of XF and SBXF were compared using an established ultra-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry (UPLC/Q-TOF-MS) method. SBXF was less toxic than XF in MIHA cells. Both XF and SBXF had anti-inflammatory effects as demonstrated by their abilities to reduce nitric oxide production as well as inducible nitric oxide synthase mRNA expression in lipopolysaccharide-stimulated RAW 264.7 macrophages. Interestingly, the anti-inflammatory effects of SBXF were more potent than that of XF. By comparing the chemical profiles, we found that seven peaks were lower, while nine other peaks were higher in SBXF than in XF. Eleven compounds including carboxyatractyloside, atractyloside and chlorogenic acid corresponding to eleven individual changed peaks were tentatively identified by matching with empirical molecular formulae and mass fragments, as well as literature data. Our study showed that stir-baking significantly reduced the cytotoxicity and enhanced the anti-inflammatory effects of XF; moreover, with a developed ultra-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry method we differentiated XF and SBXF by their chemical profiles. Further studies are warranted to establish the relationship between the alteration of chemical profiles and the changes of medicinal properties caused by stir-baking.

Magnetic Resonance Imaging Cooling-Reheating Protocol Indicates Decreased Fat Fraction via Lipid Consumption in Suspected Brown Adipose Tissue

PubMed Central

Lundström, Elin; Strand, Robin; Johansson, Lars; Bergsten, Peter; Ahlström, Håkan; Kullberg, Joel

2015-01-01

Objectives To evaluate whether a water-fat magnetic resonance imaging (MRI) cooling-reheating protocol could be used to detect changes in lipid content and perfusion in the main human brown adipose tissue (BAT) depot after a three-hour long mild cold exposure. Materials and Methods Nine volunteers were investigated with chemical-shift-encoded water-fat MRI at baseline, after a three-hour long cold exposure and after subsequent short reheating. Changes in fat fraction (FF) and R2*, related to ambient temperature, were quantified within cervical-supraclavicular adipose tissue (considered as suspected BAT, denoted sBAT) after semi-automatic segmentation. In addition, FF and R2* were quantified fully automatically in subcutaneous adipose tissue (not considered as suspected BAT, denoted SAT) for comparison. By assuming different time scales for the regulation of lipid turnover and perfusion in BAT, the changes were determined as resulting from either altered absolute fat content (lipid-related) or altered absolute water content (perfusion-related). Results sBAT-FF decreased after cold exposure (mean change in percentage points = -1.94 pp, P = 0.021) whereas no change was observed in SAT-FF (mean = 0.23 pp, P = 0.314). sBAT-R2* tended to increase (mean = 0.65 s-1, P = 0.051) and SAT-R2* increased (mean = 0.40 s-1, P = 0.038) after cold exposure. sBAT-FF remained decreased after reheating (mean = -1.92 pp, P = 0.008, compared to baseline) whereas SAT-FF decreased (mean = -0.79 pp, P = 0.008, compared to after cold exposure). Conclusions The sustained low sBAT-FF after reheating suggests lipid consumption, rather than altered perfusion, as the main cause to the decreased sBAT-FF. The results obtained demonstrate the use of the cooling-reheating protocol for detecting changes in the cervical-supraclavicular fat depot, being the main human brown adipose tissue depot, in terms of lipid content and perfusion. PMID:25928226

Magnetic resonance imaging cooling-reheating protocol indicates decreased fat fraction via lipid consumption in suspected brown adipose tissue.

PubMed

Lundström, Elin; Strand, Robin; Johansson, Lars; Bergsten, Peter; Ahlström, Håkan; Kullberg, Joel

2015-01-01

To evaluate whether a water-fat magnetic resonance imaging (MRI) cooling-reheating protocol could be used to detect changes in lipid content and perfusion in the main human brown adipose tissue (BAT) depot after a three-hour long mild cold exposure. Nine volunteers were investigated with chemical-shift-encoded water-fat MRI at baseline, after a three-hour long cold exposure and after subsequent short reheating. Changes in fat fraction (FF) and R2*, related to ambient temperature, were quantified within cervical-supraclavicular adipose tissue (considered as suspected BAT, denoted sBAT) after semi-automatic segmentation. In addition, FF and R2* were quantified fully automatically in subcutaneous adipose tissue (not considered as suspected BAT, denoted SAT) for comparison. By assuming different time scales for the regulation of lipid turnover and perfusion in BAT, the changes were determined as resulting from either altered absolute fat content (lipid-related) or altered absolute water content (perfusion-related). sBAT-FF decreased after cold exposure (mean change in percentage points = -1.94 pp, P = 0.021) whereas no change was observed in SAT-FF (mean = 0.23 pp, P = 0.314). sBAT-R2* tended to increase (mean = 0.65 s-1, P = 0.051) and SAT-R2* increased (mean = 0.40 s-1, P = 0.038) after cold exposure. sBAT-FF remained decreased after reheating (mean = -1.92 pp, P = 0.008, compared to baseline) whereas SAT-FF decreased (mean = -0.79 pp, P = 0.008, compared to after cold exposure). The sustained low sBAT-FF after reheating suggests lipid consumption, rather than altered perfusion, as the main cause to the decreased sBAT-FF. The results obtained demonstrate the use of the cooling-reheating protocol for detecting changes in the cervical-supraclavicular fat depot, being the main human brown adipose tissue depot, in terms of lipid content and perfusion.

Main regularities of SERS on semiconductors and dielectrics

NASA Astrophysics Data System (ADS)

Chelibanov, V. P.; Polubotko, A. M.

2018-04-01

The paper demonstrates that the reason of SERS on dielectrics and semiconductors is the enhancement of the electric field in the regions of the tops of the surface roughness with a very large positive curvature. The enhancement in many ways depends on the dielectric constant of the substrate and is stronger for a larger dielectric constant. The theoretical result points out that on dielectrics and semiconductors it is weaker than on metals. Experimentally it is demonstrated that there are forbidden lines on hydroquinone, adsorbed on TiO2 , which indicate on the existence of strong quadrupole light-molecule interaction in such systems.

Stabilizing the cold plasma-stimulated medium by regulating medium’s composition

NASA Astrophysics Data System (ADS)

Yan, Dayun; Nourmohammadi, Niki; Bian, Ka; Murad, Ferid; Sherman, Jonathan H.; Keidar, Michael

2016-05-01

Over past several years, the cold plasma-stimulated medium (PSM) has shown its remarkable anti-cancer capacity in par with the direct cold plasma irradiation on cancer cells or tumor tissues. Independent of the cold plasma device, PSM has noticeable advantage of being a flexible platform in cancer treatment. Currently, the largest disadvantage of PSM is its degradation during the storage over a wide temperature range. So far, to stabilize PSM, it must be remained frozen at -80 °C. In this study, we first reveal that the degradation of PSM is mainly due to the reaction between the reactive species and specific amino acids; mainly cysteine and methionine in medium. Based on this finding, both H2O2 in PSM and the anti-cancer capacity of PSM can be significantly stabilized during the storage at 8 °C and -25 °C for at least 3 days by using phosphate-buffered saline (PBS) and cysteine/methionine-free Dulbecco’s Modified Eagle Medium (DMEM). In addition, we demonstrate that adding a tyrosine derivative, 3-Nitro-L-tyrosine, into DMEM can mitigate the degradation of PSM at 8 °C during 3 days of storage. This study provides a solid foundation for the future anti-cancer application of PSM.

The Outer Solar System Origins Survey: cold classicals beyond the 2:1 resonance

NASA Astrophysics Data System (ADS)

Bannister, Michele T.; Kavelaars, J. J.; Gladman, Brett; Petit, Jean-Marc; Gwyn, Stephen; Volk, Kathryn; Chen, Ying-Tung; Alexandersen, Mike

2015-11-01

With the 85 characterised discoveries from the first quarter of the ongoing Outer Solar System Origins Survey (OSSOS) with MegaPrime on the Canada-France-Hawaii Telescope, we find that the CFEPS L7 model of Petit et al. 2011 remains an accurate parameterization of the classical Kuiper belt's orbital structure, and the population estimate for the main belt remains unchanged (for 39 AU < a < 47 AU). We independently confirm the existence of substructure within the main classical Kuiper belt. The semi-major axis distribution of the stirred component of the cold classicals must contain a clumped ‘kernel’.We detect an extension of the cold classical Kuiper belt that continues at least several AU beyond the 2:1 mean motion resonance with Neptune. This extension would have strong cosmogonic implications for the origin of the classical belt's orbital substructure.We will discuss how the 140 new objects we discovered in the second quarter of OSSOS place further constraints on cold classicals beyond the 2:1 resonance. Our 16-18 month observational arcs and improved astrometric technique continue to achieve extremely high-quality measurements of TNO orbits: fractional semimajor axis uncertainties of our discoveries are consistently in the range 0.01-0.1%, allowing rapid orbital classification.

2. VIEW TO THE SOUTHWEST OF THE MAIN EMAD BUILDING ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. VIEW TO THE SOUTHWEST OF THE MAIN E-MAD BUILDING WITH THE COLD BAY ON THE EAST (LEFT) AND THE HOT BAY ON THE WEST (RIGHT). - Nevada Test Site, Engine Maintenance Assembly & Disassembly Facility, Area 25, Jackass Flats, Mercury, Nye County, NV

Cross-frontal cold jets near Iceland: In-water, satellite infrared, and Geosat altimeter data

NASA Astrophysics Data System (ADS)

Scott, John C.; McDowall, Anne L.

1990-10-01

This paper reports detailed in-water observations and satellite infrared images which are approximately coincident with a single Geosat altimeter track across the Iceland-Faeroes Frontal Zone. The ARE thermistor chain covered the upper 300 m of the ocean along the track, and the first two of a long sequence of NOAA satellite infrared images were obtained, all within 24 hours of the Geosat overpass. The data are interpreted as showing cold cross-frontal jets related to the formation of cold eddies south of the main frontal boundary. Implications for the use of altimetry for ocean monitoring are considered.

Rapid Quadrupole-Time-of-Flight Mass Spectrometry Method Quantifies Oxygen-Rich Lignin Compound in Complex Mixtures

NASA Astrophysics Data System (ADS)

Boes, Kelsey S.; Roberts, Michael S.; Vinueza, Nelson R.

2018-03-01

Complex mixture analysis is a costly and time-consuming task facing researchers with foci as varied as food science and fuel analysis. When faced with the task of quantifying oxygen-rich bio-oil molecules in a complex diesel mixture, we asked whether complex mixtures could be qualitatively and quantitatively analyzed on a single mass spectrometer with mid-range resolving power without the use of lengthy separations. To answer this question, we developed and evaluated a quantitation method that eliminated chromatography steps and expanded the use of quadrupole-time-of-flight mass spectrometry from primarily qualitative to quantitative as well. To account for mixture complexity, the method employed an ionization dopant, targeted tandem mass spectrometry, and an internal standard. This combination of three techniques achieved reliable quantitation of oxygen-rich eugenol in diesel from 300 to 2500 ng/mL with sufficient linearity (R2 = 0.97 ± 0.01) and excellent accuracy (percent error = 0% ± 5). To understand the limitations of the method, it was compared to quantitation attained on a triple quadrupole mass spectrometer, the gold standard for quantitation. The triple quadrupole quantified eugenol from 50 to 2500 ng/mL with stronger linearity (R2 = 0.996 ± 0.003) than the quadrupole-time-of-flight and comparable accuracy (percent error = 4% ± 5). This demonstrates that a quadrupole-time-of-flight can be used for not only qualitative analysis but also targeted quantitation of oxygen-rich lignin molecules in complex mixtures without extensive sample preparation. The rapid and cost-effective method presented here offers new possibilities for bio-oil research, including: (1) allowing for bio-oil studies that demand repetitive analysis as process parameters are changed and (2) making this research accessible to more laboratories. [Figure not available: see fulltext.

Conceptual design of a compact high gradient quadrupole magnet of varying strength using permanent magnets

NASA Astrophysics Data System (ADS)

Sinha, Gautam

2018-02-01

A concept is presented to design magnets using cylindrical-shaped permanent-magnet blocks, where various types of magnetic fields can be produced by either rotating or varying the size of the magnetic blocks within a given mechanical structure. A general method is introduced to calculate the 3D magnetic field produced by a set of permanent magnets. An analytical expression of the 2D field and the condition to generate various magnetic fields like dipole, quadrupole, and sextupole are derived. Using the 2D result as a starting point, a computer code is developed to get the optimum orientation of the magnets to obtain the user-specific target field profile over a given volume in 3D. Designs of two quadrupole magnets are presented, one using 12 and the other using 24 permanent-magnet blocks. Variation of the quadrupole strength is achieved using tuning coils of a suitable current density and specially designed end tubes. A new concept is introduced to reduce the integrated quadrupole field strength by inserting two hollow cylindrical tubes made of iron, one at each end. This will not affect the field gradient at the center but reduce the integrated field strength by shielding the magnetic field near the ends where the tubes are inserted. The advantages of this scheme are that it is easy to implement, the magnetic axis will not shift, and it will prevent interference with nearby devices. Around 40% integrated field variation is achieved using this method in the present example. To get a realistic estimation of the field quality, a complete 3D model using a nonlinear B -H curve is also studied using a finite-element-based computer code. An example to generate around an 80 T /m quadrupole field gradient is also presented.

Rapid Quadrupole-Time-of-Flight Mass Spectrometry Method Quantifies Oxygen-Rich Lignin Compound in Complex Mixtures

NASA Astrophysics Data System (ADS)

Boes, Kelsey S.; Roberts, Michael S.; Vinueza, Nelson R.

2017-12-01

Complex mixture analysis is a costly and time-consuming task facing researchers with foci as varied as food science and fuel analysis. When faced with the task of quantifying oxygen-rich bio-oil molecules in a complex diesel mixture, we asked whether complex mixtures could be qualitatively and quantitatively analyzed on a single mass spectrometer with mid-range resolving power without the use of lengthy separations. To answer this question, we developed and evaluated a quantitation method that eliminated chromatography steps and expanded the use of quadrupole-time-of-flight mass spectrometry from primarily qualitative to quantitative as well. To account for mixture complexity, the method employed an ionization dopant, targeted tandem mass spectrometry, and an internal standard. This combination of three techniques achieved reliable quantitation of oxygen-rich eugenol in diesel from 300 to 2500 ng/mL with sufficient linearity (R2 = 0.97 ± 0.01) and excellent accuracy (percent error = 0% ± 5). To understand the limitations of the method, it was compared to quantitation attained on a triple quadrupole mass spectrometer, the gold standard for quantitation. The triple quadrupole quantified eugenol from 50 to 2500 ng/mL with stronger linearity (R2 = 0.996 ± 0.003) than the quadrupole-time-of-flight and comparable accuracy (percent error = 4% ± 5). This demonstrates that a quadrupole-time-of-flight can be used for not only qualitative analysis but also targeted quantitation of oxygen-rich lignin molecules in complex mixtures without extensive sample preparation. The rapid and cost-effective method presented here offers new possibilities for bio-oil research, including: (1) allowing for bio-oil studies that demand repetitive analysis as process parameters are changed and (2) making this research accessible to more laboratories. [Figure not available: see fulltext.

Rapid Quadrupole-Time-of-Flight Mass Spectrometry Method Quantifies Oxygen-Rich Lignin Compound in Complex Mixtures.

PubMed

Boes, Kelsey S; Roberts, Michael S; Vinueza, Nelson R

2018-03-01

Complex mixture analysis is a costly and time-consuming task facing researchers with foci as varied as food science and fuel analysis. When faced with the task of quantifying oxygen-rich bio-oil molecules in a complex diesel mixture, we asked whether complex mixtures could be qualitatively and quantitatively analyzed on a single mass spectrometer with mid-range resolving power without the use of lengthy separations. To answer this question, we developed and evaluated a quantitation method that eliminated chromatography steps and expanded the use of quadrupole-time-of-flight mass spectrometry from primarily qualitative to quantitative as well. To account for mixture complexity, the method employed an ionization dopant, targeted tandem mass spectrometry, and an internal standard. This combination of three techniques achieved reliable quantitation of oxygen-rich eugenol in diesel from 300 to 2500 ng/mL with sufficient linearity (R 2 = 0.97 ± 0.01) and excellent accuracy (percent error = 0% ± 5). To understand the limitations of the method, it was compared to quantitation attained on a triple quadrupole mass spectrometer, the gold standard for quantitation. The triple quadrupole quantified eugenol from 50 to 2500 ng/mL with stronger linearity (R 2 = 0.996 ± 0.003) than the quadrupole-time-of-flight and comparable accuracy (percent error = 4% ± 5). This demonstrates that a quadrupole-time-of-flight can be used for not only qualitative analysis but also targeted quantitation of oxygen-rich lignin molecules in complex mixtures without extensive sample preparation. The rapid and cost-effective method presented here offers new possibilities for bio-oil research, including: (1) allowing for bio-oil studies that demand repetitive analysis as process parameters are changed and (2) making this research accessible to more laboratories. Graphical Abstract ᅟ.

Liquid nitrogen historical and current usage of the central helium liquefier at SNS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Neustadt, Thomas S.; Kim, Sang-Ho; Howell, Matthew P.

The main cryogenic system for the Spallation Neutron Source (SNS) is comprised of a 4-K cold box, a 2-K cold box, six warm compressors, and ancillary support equipment. This system has been cold and operating with little disruption since 2005. Design and operation of liquid nitrogen (LN2) supplied from a single 20,000-gallon supply Dewar will be discussed. LN2 used to precool the 4-K cold box heat exchanger started to increase around 2011. LN2 Consumption during 2012 and 2013 was almost double the nominal usage rate. Studies of this data, plant parameter changes to respond to this information, and current interpretationsmore » are detailed in this paper. The usage rate of LN2 returned to normal in late 2013 and remained there until recent additional changes. Future study plans to understand potential causes of this including contamination migration within the 4-K cold box will also be addressed.« less

Cold denaturation of α-synuclein amyloid fibrils.

PubMed

Ikenoue, Tatsuya; Lee, Young-Ho; Kardos, József; Saiki, Miyu; Yagi, Hisashi; Kawata, Yasushi; Goto, Yuji

2014-07-21

Although amyloid fibrils are associated with numerous pathologies, their conformational stability remains largely unclear. Herein, we probe the thermal stability of various amyloid fibrils. α-Synuclein fibrils cold-denatured to monomers at 0-20 °C and heat-denatured at 60-110 °C. Meanwhile, the fibrils of β2-microglobulin, Alzheimer's Aβ1-40/Aβ1-42 peptides, and insulin exhibited only heat denaturation, although they showed a decrease in stability at low temperature. A comparison of structural parameters with positive enthalpy and heat capacity changes which showed opposite signs to protein folding suggested that the burial of charged residues in fibril cores contributed to the cold denaturation of α-synuclein fibrils. We propose that although cold-denaturation is common to both native proteins and misfolded fibrillar states, the main-chain dominated amyloid structures may explain amyloid-specific cold denaturation arising from the unfavorable burial of charged side-chains in fibril cores. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Basic distinctions between cold- and hot-fusion reactions in the synthesis of superheavy elements

NASA Astrophysics Data System (ADS)

Nasirov, A. K.; Muminov, A. I.; Giardina, G.; Mandaglio, G.

2014-07-01

Superheavy elements (SHE) of charge number in the range of Z = 106-112 were synthesized in so-called cold-fusion reactions. The smallness of the excitation energy of compound nuclei is the main advantage of cold-fusion reactions. However, the synthesis of SHEs of charge number in the region of Z ≥ 112 is strongly complicated in cold-fusion reactions by a sharp decrease in the cross section of a compound nucleus formation in the entrance channel because of superiority of quasifission in the competition with complete fusion. Two favorable circumstances contributed to the success of the experiments aimed at the synthesis of the Z = 113-118 elements and performed at the Laboratory of Nuclear Reactions at the Joint Institute for Nuclear Research: large cross sections for the production of a compound nucleus, which are characteristic of hot-fusion reactions, and an increase in the fission barrier for nuclei toward the stability island. The factor that complicates the formation of a compound nucleus in cold-fusion reactions is discussed.

Consumer attitudes on cough and cold: US (ACHOO) survey results.

PubMed

Blaiss, M S; Dicpinigaitis, P V; Eccles, R; Wingertzahn, M A

2015-08-01

The Attitudes of Consumers Toward Health, Cough, and Cold (ACHOO) survey was developed to better inform health care providers on the natural history and impact of common cold and cough, and related consumer experience and behaviors. Randomly selected US Internet/mobile device users were invited to participate in an online survey (N = 3333) in October 2012. Response quotas modeled upon 2010 US Census data ensured a demographically representative sample. To reduce potential bias from the quota design, 75% of the completed surveys were randomly selected as the primary analysis pool. Survey questions assessed participant demographics, frequency and duration of cough/cold symptoms, impact of symptoms on daily life, treatment preferences, and knowledge about cough/cold pathophysiology. In the past year, 84.6% of respondents had experienced at least one cold. Colds typically started with sore/scratchy throat (39.2%), nasal congestion (9.8%), and runny nose (9.3%) and lasted 3-7 days. Cough, the most common cold symptom (73.1%), had a delayed onset (typically 1-5 days after cold onset) and a long duration (>6 days in 35.2%). Nasal congestion and cough were the most bothersome symptoms. Many respondents waited until symptoms were 'bad enough' (42.6%) or multiple symptoms were present (20.2%) before using nonprescription medications. Drivers of choice included effectiveness in relieving symptoms, safety, and past experience. Respondents rarely consulted clinicians regarding treatment, and more than three-quarters had never received instructions from a clinician on how to choose a nonprescription cough/cold medication. Misperceptions regarding etiology and treatment of the common cold were prevalent. The main limitation is potential recall bias, since respondents had to recall cough/cold episodes over the prior year. The ACHOO survey confirms that cold is a common, bothersome experience and that there are gaps in consumers' knowledge of pathophysiology and appropriate management of cough/cold.

Cold growth behaviour and genetic comparison of Canadian and Swiss Listeria monocytogenes strains associated with the food supply chain and human listeriosis cases.

PubMed

Arguedas-Villa, Carolina; Kovacevic, Jovana; Allen, Kevin J; Stephan, Roger; Tasara, Taurai

2014-06-01

Sixty-two strains of Listeria monocytogenes isolated in Canada and Switzerland were investigated. Comparison based on molecular genotypes confirmed that strains in these two countries are genetically diverse. Interestingly strains from both countries displayed similar range of cold growth phenotypic profiles. Based on cold growth lag phase duration periods displayed in BHI at 4 °C, the strains were similarly divided into groups of fast, intermediate and slow cold adaptors. Overall Swiss strains had faster exponential cold growth rates compared to Canadian strains. However gene expression analysis revealed no significant differences between fast and slow cold adapting strains in the ability to induce nine cold adaptation genes (lmo0501, cspA, cspD, gbuA, lmo0688, pgpH, sigB, sigH and sigL) in response to cold stress exposure. Neither was the presence of Stress survival islet 1 (SSI-1) analysed by PCR associated with enhanced cold adaptation. Phylogeny based on the sigL gene subdivided strains from these two countries into two major and one minor cluster. Fast cold adaptors were more frequently in one of the major clusters (cluster A), whereas slow cold adaptors were mainly in the other (cluster B). Genetic differences between these two major clusters are associated with various amino acid substitutions in the predicted SigL proteins. Compared to the EGDe type strain and most slow cold adaptors, most fast cold adaptors exhibited five identical amino acid substitutions (M90L, S203A/S203T, S304N, S315N, and I383T) in their SigL proteins. We hypothesize that these amino acid changes might be associated with SigL protein structural and functional changes that may promote differences in cold growth behaviour between L. monocytogenes strains. Copyright © 2014 Elsevier Ltd. All rights reserved.

Machine Imperfection Studies of the RAON Superconducting Linac

NASA Astrophysics Data System (ADS)

Jeon, D.; Jang, J.-H.; Jin, H.

2018-05-01

Studies of the machine imperfections in the RAON superconducting linac (SCL) that employs normal conducting (NC) quadrupoles were done to assess the tolerable error budgets of the machine imperfections that ensure operation of the beam. The studies show that the beam loss requirement is met even before the orbit correction and that the beam loss requirement is met even without the MHB (multi-harmonic buncher) and VE (velocity equalizer) thanks to the RAON's radio-frequency quadrupole (RFQ) design feature. For the low energy section of the linac (SCL3), a comparison is made between the two superconducting linac lattice types: one lattice that employs NC quadrupoles and the other that employs SC solenoids. The studies show that both lattices meet the beam loss requirement after the orbit correction. However, before the orbit correction, the lattice employing SC solenoids does not meet the beam loss requirement and can cause a significant beam loss, while the lattice employing NC quadrupoles meets the requirement. For the lattice employing SC solenoids, care must be taken during the beam commissioning.

The exact calculation of quadrupole sources for some incompressible flows

NASA Technical Reports Server (NTRS)

Brentner, Kenneth S.

1988-01-01

This paper is concerned with the application of the acoustic analogy of Lighthill to the acoustic and aerodynamic problems associated with moving bodies. The Ffowcs Williams-Hawkings equation, which is an interpretation of the acoustic analogy for sound generation by moving bodies, manipulates the source terms into surface and volume sources. Quite often in practice the volume sources, or quadrupoles, are neglected for various reasons. Recently, Farassat, Long and others have attempted to use the FW-H equation with the quadrupole source and neglected to solve for the surface pressure on the body. The purpose of this paper is to examine the contribution of the quadrupole source to the acoustic pressure and body surface pressure for some problems for which the exact solution is known. The inviscid, incompressible, 2-D flow, calculated using the velocity potential, is used to calculate the individual contributions of the various surface and volume source terms in the FW-H equation. The relative importance of each of the sources is then assessed.

Investigation of an enhanced resolution triple quadrupole mass spectrometer for high-throughput liquid chromatography/tandem mass spectrometry assays.

PubMed

Yang, Liyu; Amad, Ma'an; Winnik, Witold M; Schoen, Alan E; Schweingruber, Hans; Mylchreest, Iain; Rudewicz, Patrick J

2002-01-01

Triple quadrupole mass spectrometers, when operated in multiple reaction monitoring (MRM) mode, offer a unique combination of sensitivity, specificity, and dynamic range. Consequently, the triple quadrupole is the workhorse for high-throughput quantitation within the pharmaceutical industry. However, in the past, the unit mass resolution of quadrupole instruments has been a limitation when interference from matrix or metabolites cannot be eliminated. With recent advances in instrument design, triple quadrupole instruments now afford mass resolution of less than 0.1 Dalton (Da) full width at half maximum (FWHM). This paper describes the evaluation of an enhanced resolution triple quadrupole mass spectrometer for high-throughput bioanalysis with emphasis on comparison of selectivity, sensitivity, dynamic range, precision, accuracy, and stability under both unit mass (1 Da FWHM) and enhanced (

Theory for nanoparticle retention time in the helical channel of quadrupole magnetic field-flow fractionation

NASA Astrophysics Data System (ADS)

Williams, P. Stephen; Carpino, Francesca; Zborowski, Maciej

2009-05-01

Quadrupole magnetic field-flow fractionation (QMgFFF) is a separation and characterization technique for magnetic nanoparticles such as those used for cell labeling and for targeted drug therapy. A helical separation channel is used to efficiently exploit the quadrupole magnetic field. The fluid and sample components therefore have angular and longitudinal components to their motion in the thin annular space occupied by the helical channel. The retention ratio is defined as the ratio of the times for non-retained and a retained material to pass through the channel. Equations are derived for the respective angular and longitudinal components to retention ratio.

Search for Quadrupole Strength in the Electroexcitation of the Delta+ (1232)

DOE Office of Scientific and Technical Information (OSTI.GOV)

C. Mertz; C. Vellidis; Ricardo Alarcon

2001-04-01

High precision 1H(e, e'p)pi0 measurements at Q2 = 0.126. (GeV/c)2 are reported, which allow the determination of quadrupole amplitudes in the gamma*N --> Delta transition; they simultaneously test the reliability of electroproduction models. The derived quadrupole-to-dipole (I = 3/2) amplitude ratios, RSM = (-6.5 +/- 0.2stat+sys+/-2.5mod)% and REM = 9-2.1 +/-0.2stat+sys +/-2.0mod)%, are dominated by model error. Previous RSM and REM results should be reconsidered after the model uncertainties associated with the method of their extraction are taken into account.

Engineering quadrupole magnetic flow sorting for the isolation of pancreatic islets

NASA Astrophysics Data System (ADS)

Kennedy, David J.; Todd, Paul; Logan, Sam; Becker, Matthew; Papas, Klearchos K.; Moore, Lee R.

2007-04-01

Quadrupole magnetic flow sorting (QMS) is being adapted from the separation of suspensions of single cells (<15 μm) to the isolation of pancreatic islets (150-350 μm) for transplant. To achieve this goal, the critical QMS components have been modeled and engineered to optimize the separation process. A flow channel has been designed, manufactured, and tested. The quadrupole magnet assembly has been designed and verified by finite element analysis. Pumps have been selected and verified by test. Test data generated from the pumps and flow channel demonstrate that the fabricated channel and peristaltic pumps fulfill the requirements of successful QMS separation.

On the sound field radiated by a tuning fork

NASA Astrophysics Data System (ADS)

Russell, Daniel A.

2000-12-01

When a sounding tuning fork is brought close to the ear, and rotated about its long axis, four distinct maxima and minima are heard. However, when the same tuning fork is rotated while being held at arm's length from the ear only two maxima and minima are heard. Misconceptions concerning this phenomenon are addressed and the fundamental mode of the fork is described in terms of a linear quadrupole source. Measured directivity patterns in the near field and far field of several forks agree very well with theoretical predictions for a linear quadrupole. Other modes of vibration are shown to radiate as dipole and lateral quadrupole sources.

An effect of nuclear electric quadrupole moments in thermonuclear fusion plasmas

NASA Technical Reports Server (NTRS)

De, B. R.; Srnka, L. J.

1978-01-01

Consideration of the nuclear electric quadrupole terms in the expression for the fusion Coulomb barrier suggests that this electrostatic barrier may be substantially modified from that calculated under the usual plasma assumption that the nuclei are electric monopoles. This effect is a result of the nonspherical potential shape and the spatial quantization of the nuclear spins of the fully stripped ions in the presence of a magnetic field. For monopole-quadrupole fuel cycles like p-B-11, the fusion cross-section may be substantially increased at low energies if the protons are injected at a small angle relative to the confining magnetic field.

Genome-wide transcriptomic analysis of response to low temperature reveals candidate genes determining divergent cold-sensitivity of maize inbred lines.

PubMed

Sobkowiak, Alicja; Jończyk, Maciej; Jarochowska, Emilia; Biecek, Przemysław; Trzcinska-Danielewicz, Joanna; Leipner, Jörg; Fronk, Jan; Sowiński, Paweł

2014-06-01

Maize, despite being thermophyllic due to its tropical origin, demonstrates high intraspecific diversity in cold-tolerance. To search for molecular mechanisms of this diversity, transcriptomic response to cold was studied in two inbred lines of contrasting cold-tolerance. Microarray analysis was followed by extensive statistical elaboration of data, literature data mining, and gene ontology-based classification. The lines used had been bred earlier specifically for determination of QTLs for cold-performance of photosynthesis. This allowed direct comparison of present transcriptomic data with the earlier QTL mapping results. Cold-treated (14 h at 8/6 °C) maize seedlings of cold-tolerant ETH-DH7 and cold-sensitive ETH-DL3 lines at V3 stage showed strong, consistent response of the third leaf transcriptome: several thousand probes showed similar, statistically significant change in both lines, while only tens responded differently in the two lines. The most striking difference between the responses of the two lines to cold was the induction of expression of ca. twenty genes encoding membrane/cell wall proteins exclusively in the cold-tolerant ETH-DH7 line. The common response comprised mainly repression of numerous genes related to photosynthesis and induction of genes related to basic biological activity: transcription, regulation of gene expression, protein phosphorylation, cell wall organization. Among the genes showing differential response, several were close to the QTL regions identified in earlier studies with the same inbred lines and associated with biometrical, physiological or biochemical parameters. These transcripts, including two apparently non-protein-coding ones, are particularly attractive candidates for future studies on mechanisms determining divergent cold-tolerance of inbred maize lines.

The Planck Catalogue of Galactic Cold Clumps : Looking at the early stages of star-formation

NASA Astrophysics Data System (ADS)

Montier, Ludovic

2015-08-01

The Planck satellite has provided an unprecedented view of the submm sky, allowing us to search for the dust emission of Galactic cold sources. Combining Planck-HFI all-sky maps in the high frequency channels with the IRAS map at 100um, we built the Planck catalogue of Galactic Cold Clumps (PGCC, Planck 2015 results XXVIII 2015), counting 13188 sources distributed over the whole sky, and following mainly the Galactic structures at low and intermediate latitudes. This is the first all-sky catalogue of Galactic cold sources obtained with a single instrument at this resolution and sensitivity, which opens a new window on star-formation processes in our Galaxy.I will briefly describe the colour detection method used to extract the Galactic cold sources, i.e., the Cold Core Colour Detection Tool (CoCoCoDeT, Montier et al. 2010), and its application to the Planck data. I will discuss the statistical distribution of the properties of the PGCC sources (in terms of dust temperature, distance, mass, density and luminosity), which illustrates that the PGCC catalogue spans a large variety of environments and objects, from molecular clouds to cold cores, and covers various stages of evolution. The Planck catalogue is a very powerful tool to study the formation and the evolution of prestellar objects and star-forming regions.I will finally present an overview of the Herschel Key Program Galactic Cold Cores (PI. M.Juvela), which allowed us to follow-up about 350 Planck Galactic Cold Clumps, in various stages of evolution and environments. With this program, the nature and the composition of the 5' Planck sources have been revealed at a sub-arcmin resolution, showing very different configurations, such as starless cold cores or multiple Young Stellar objects still embedded in their cold envelope.

Mössbauer studies of subfossil oak

NASA Astrophysics Data System (ADS)

van Bürck, Uwe; Wagner, Friedrich E.; Lerf, Anton

2012-03-01

Subfossil oak wood found in a dried-up bog in Bavaria, Germany, was studied by Mössbauer spectroscopy. The bog oaks contain substantial amounts of iron taken up from the bog waters and presumably forming complexes with the tanning agents in the oak wood. The iron is mainly Fe3 + and much of this exhibits an uncommonly large quadrupole splitting of up to 1.6 mm/s that can tentatively be explained by the formation of oxo-bridged iron dimers. Only rarely, mainly in the dense wood of the roots of bog oaks, was divalent iron found. When the wood was ground to a powder the divalent iron oxidized to Fe3 + within hours. This suggests that iron is taken up from the bog water as Fe2 + and oxidizes only when the wood emerges from the water and comes into contact with air.

The LHC magnet system and its status of development

NASA Technical Reports Server (NTRS)

Bona, Maurizio; Perin, Romeo; Vlogaert, Jos

1995-01-01

CERN is preparing for the construction of a new high energy accelerator/collider, the Large Hadron Collider (LHC). This new facility will mainly consist of two superconducting magnetic beam channels, 27 km long, to be installed in the existing LEP tunnel. The magnetic system comprises about 1200 twin-aperture dipoles, 13.145 m long, with an operational field of 8.65 T, about 600 quadrupoles, 3 m long, and a very large number of other superconducting magnetic components. A general description of the system is given together with the main features of the design of the regular lattice magnets. The paper also describes the present state of the magnet R & D program. Results from short model work, as well as from full scale prototypes will be presented, including the recently tested 10 m long full-scale prototype dipole manufactured in industry.

Malignancy in solitary solid cold thyroid nodule.

PubMed

Fariduddin, M; Amin, A H; Ahmed, M U; Karim, S S; Moslem, F; Kamal, M

2012-04-01

Solitary thyroid nodule is a common endocrine problem. The main concern of solitary thyroid nodule lies in excluding the malignancy & to operate on as few patients as possible. Other than history & clinical examination, hormone assessment, USG of thyroid gland, radionuclide scan & FNAC were used to differentiate malignant nodules from benign ones. In this study 127 cases with solitary thyroid nodule of all age group & both sexes were included from Endocrine & Thyroid clinic of BSMMU. They were clinically & biochemically euthyroid & had cold nodule on radionuclide scan. USG & FNAC were done & subsequently they underwent surgical procedure. On the basis of postoperative histopathological report the specimens were divided into benign & malignant groups. All the nodules were cold among which 104 were solid & 23 were mixed in consistency. Of the 104 solid cold nodules histopathology revealed 36(34.6%) malignant & 68(65.4%) benign cases. From the 23 mixed cold solitary nodule 5(21.7%) appeared malignant & 18(78.3%) were benign. So malignancy was higher in solid cold group than the mixed cold one but this was not statistically significant (p=0.673). FNAC was done & it revealed that 83(65.5%) cases were benign, 10(7.8%) cases were suspicious & 34(26.7%) were malignant. Finally histopathology showed 41(32.3%) cases were positive & 86(67.7%) cases were negative for malignancy.

Correlation between y-type ions observed in ion trap and triple quadrupole mass spectrometers.

PubMed

Sherwood, Carly A; Eastham, Ashley; Lee, Lik Wee; Risler, Jenni; Vitek, Olga; Martin, Daniel B

2009-09-01

Multiple reaction monitoring mass spectrometry (MRM-MS) is a technique for high-sensitivity targeted analysis. In proteomics, MRM-MS can be used to monitor and quantify a peptide based on the production of expected fragment peaks from the selected peptide precursor ion. The choice of which fragment ions to monitor in order to achieve maximum sensitivity in MRM-MS can potentially be guided by existing MS/MS spectra. However, because the majority of discovery experiments are performed on ion trap platforms, there is concern in the field regarding the generalizability of these spectra to MRM-MS on a triple quadrupole instrument. In light of this concern, many operators perform an optimization step to determine the most intense fragments for a target peptide on a triple quadrupole mass spectrometer. We have addressed this issue by targeting, on a triple quadrupole, the top six y-ion peaks from ion trap-derived consensus library spectra for 258 doubly charged peptides from three different sample sets and quantifying the observed elution curves. This analysis revealed a strong correlation between the y-ion peak rank order and relative intensity across platforms. This suggests that y-type ions obtained from ion trap-based library spectra are well-suited for generating MRM-MS assays for triple quadrupoles and that optimization is not required for each target peptide.

A preference for edgewise interactions between aromatic rings and carboxylate anions: the biological relevance of anion-quadrupole interactions.

PubMed

Jackson, Michael R; Beahm, Robert; Duvvuru, Suman; Narasimhan, Chandrasegara; Wu, Jun; Wang, Hsin-Neng; Philip, Vivek M; Hinde, Robert J; Howell, Elizabeth E

2007-07-19

Noncovalent interactions are quite important in biological structure-function relationships. To study the pairwise interaction of aromatic amino acids (phenylalanine, tyrosine, tryptophan) with anionic amino acids (aspartic and glutamic acids), small molecule mimics (benzene, phenol or indole interacting with formate) were used at the MP2 level of theory. The overall energy associated with an anion-quadrupole interaction is substantial (-9.5 kcal/mol for a benzene-formate planar dimer at van der Waals contact distance), indicating the electropositive ring edge of an aromatic group can interact with an anion. Deconvolution of the long-range coplanar interaction energy into fractional contributions from charge-quadrupole interactions, higher-order electrostatic interactions, and polarization terms was achieved. The charge-quadrupole term contributes between 30 to 45% of the total MP2 benzene-formate interaction; most of the rest of the interaction arises from polarization contributions. Additional studies of the Protein Data Bank (PDB Select) show that nearly planar aromatic-anionic amino acid pairs occur more often than expected from a random angular distribution, while axial aromatic-anionic pairs occur less often than expected; this demonstrates the biological relevance of the anion-quadrupole interaction. While water may mitigate the strength of these interactions, they may be numerous in a typical protein structure, so their cumulative effect could be substantial.

Disturbance is the key to plant invasions in cold environments.

PubMed

Lembrechts, Jonas J; Pauchard, Aníbal; Lenoir, Jonathan; Nuñez, Martín A; Geron, Charly; Ven, Arne; Bravo-Monasterio, Pablo; Teneb, Ernesto; Nijs, Ivan; Milbau, Ann

2016-12-06

Until now, nonnative plant species were rarely found at high elevations and latitudes. However, partly because of climate warming, biological invasions are now on the rise in these extremely cold environments. These plant invasions make it timely to undertake a thorough experimental assessment of what has previously been holding them back. This knowledge is key to developing efficient management of the increasing risks of cold-climate invasions. Here, we integrate human interventions (i.e., disturbance, nutrient addition, and propagule input) and climatic factors (i.e., temperature) into one seed-addition experiment across two continents: the subantarctic Andes and subarctic Scandinavian mountains (Scandes), to disentangle their roles in limiting or favoring plant invasions. Disturbance was found as the main determinant of plant invader success (i.e., establishment, growth, and flowering) along the entire cold-climate gradient, explaining 40-60% of the total variance in our models, with no indication of any facilitative effect from the native vegetation. Higher nutrient levels additionally stimulated biomass production and flowering. Establishment and flowering displayed a hump-shaped response with increasing elevation, suggesting that competition is the main limit on invader success at low elevations, as opposed to low-growing-season temperatures at high elevations. Our experiment showed, however, that nonnative plants can establish, grow, and flower well above their current elevational limits in high-latitude mountains. We thus argue that cold-climate ecosystems are likely to see rapid increases in plant invasions in the near future as a result of a synergistic interaction between increasing human-mediated disturbances and climate warming.

Characterization of metabolites of larotaxel in rat by liquid chromatography coupled with Q exactive high-resolution benchtop quadrupole orbitrap mass spectrometer.

PubMed

Liu, Zhenzhen; Hou, Pengyi; Liu, Lian; Qian, Feng

2018-03-01

1. Liquid-chromatography (LC) high-resolution (HR) mass spectrometry (MS) analysis can record HR full scans for drug metabolism studies. Larotaxel is a taxane analog that has the potential for the treatment of various types of cancer. 2. In this study, the metabolism of larotaxel was evaluated after an intravenous dose of 8 mg/kg via the caudal vein to healthy rats and its metabolites were characterized by high performance liquid chromatography coupled with a Q Exactive high-resolution benchtop quadrupole orbitrap mass spectrometer. Rat bio-samples were separated on a Capcell Pak C 18 column (2.1 i.d. × 100 mm; 2.7 μm) with mobile phase of acetonitrile and water. 3. As a result, a total of 34 metabolites were detected and identified by comparing the molecular masses, retention times and spectral patterns of the analytes with those of the parent drug. Three metabolites were confirmed by comparison with reference substances. 4. The prominent metabolites were mainly hydroxyl, dihydroxyl, trihydroxyl and 10-desacetyl analogs of larotaxel, some of which resulted from oxidation of the tert-butyl groups on the side chain and further oxidation and cyclization of the tert-butyl hydroxylated metabolites.

The Distribution of Galaxies’ Gravitational Field Stemming from Their Tidal Interaction

NASA Astrophysics Data System (ADS)

Stephanovich, Vladimir; Godłowski, Włodzimierz

2015-09-01

We calculate the distribution function of astronomical objects’ (like galaxies and/or smooth halos of different kinds) gravitational fields due to their tidal interaction. For that we apply the statistical method of Chandrasekhar, used originally to calculate the famous Holtzmark distribution. We show that in our approach the distribution function is never Gaussian, its form being dictated by the potential of interaction between objects. This calculation permits us to perform a theoretical analysis of the relation between angular momentum and mass (richness) of the galaxy clusters. To do so, we follow the ideas of Catelan & Theuns and Heavens & Peacock. The main difference is that here we reduce the problem to a discrete many-body case, where all physical properties of the system are determined by the interaction potential V({{\\boldsymbol{r}}}{ij}). The essence of reduction is that we use the multipole (up to quadrupole here) expansion of Newtonian potential so that all hydrodynamic, “extended” characteristics of an object, such as its density mass, are “integrated out,” leaving its “point-like” characteristics, such as mass and quadrupole moment. In that sense we do not distinguish between galaxies and smooth components such as halos. We compare our theoretical results with observational data.

Quadrupole distribution generated by a laser induced plasma (LIP) in air in earliest instants using pulses of 532 or 355 nm

NASA Astrophysics Data System (ADS)

Paulin-Fuentes, J. Mauricio; Sánchez-Aké, C.; Bredice, Fausto O.; Villagrán-Muniz, Mayo

2015-07-01

The self-generated electric and magnetic fields in laser induced plasmas (LIPs) in air during the first 40 ns are experimentally investigated using different electric, magnetic and optical techniques. To produce LIPs we used the second and third harmonics (532 and 355 nm) of a Nd:YAG nanosecond pulsed laser with a range of irradiance from {{10}11} to {{10}12} W \\text{c}{{\\text{m}}-2} . The variation in time of the electric field was detected using the tip of a coaxial cable, and the spontaneous magnetic field (SMF) was measured using a \\dot{B} probe. The spatial and temporal evolution of the plasma was studied using shadowgraphy and fast photography. It was observed that produced LIPs using pulses of 532 and 355 nm, generate plasmas of double core over the laser axis, while we observed that produced LIPs by pulses of 1064 nm are composed of a single core plasma. We found that the double-core plasmas have a quadrupole distribution of the charge, consisting of two oppositely directed dipoles which in turn correspond to each plasma core. The magnetic diagnostic showed an oscillating magnetic field azimuthal to the main axis of the double-plasma.

Errors and optics study of a permanent magnet quadrupole system

NASA Astrophysics Data System (ADS)

Schillaci, F.; Maggiore, M.; Rifuggiato, D.; Cirrone, G. A. P.; Cuttone, G.; Giove, D.

2015-05-01

Laser-based accelerators are gaining interest in recent years as an alternative to conventional machines [1]. Nowadays, energy and angular spread of the laser-driven beams are the main issues in application and different solutions for dedicated beam-transport lines have been proposed [2,3]. In this context a system of permanent magnet quadrupoles (PMQs) is going to be realized by INFN [2] researchers, in collaboration with SIGMAPHI [3] company in France, to be used as a collection and pre-selection system for laser driven proton beams. The definition of well specified characteristics, both in terms of performances and field quality, of the magnetic lenses is crucial for the system realization, for an accurate study of the beam dynamics and the proper matching with a magnetic selection system already realized [6,7]. Hence, different series of simulations have been used for studying the PMQs harmonic contents and stating the mechanical and magnetic tolerances in order to have reasonable good beam quality downstream the system. In this paper is reported the method used for the analysis of the PMQs errors and its validation. Also a preliminary optics characterization is presented in which are compared the effects of an ideal PMQs system with a perturbed system on a monochromatic proton beams.

Identification of the one-quadrupole phonon 2 1 , m s + state of 204Hg

DOE PAGES

Stegmann, R.; Stahl, C.; Rainovski, G.; ...

2017-04-19

One-phonon states of vibrational nuclei with mixed proton–neutron symmetry have been observed throughout the nuclear chart besides the mass A ≈ 200 region. Very recently, it has been proposed that the 2 + 2 state of 212Po is of isovector nature. This nucleus has two valence protons and two valence neutrons outside the doubly-magic 208Pb nucleus. The stable isotope 204Hg, featuring two valence-proton and valence-neutron holes, with respect to 208Pb, is the particle-hole mirror of 212Po. In order to compare the properties of low-lying isovector excitations in these particle-hole mirror nuclei, we have studied 204Hg by using the projectile Coulomb-excitationmore » technique. The measured absolute B( M1;2 + 2 → 2 + 1) strength of 0.20 (2) μ 2 N indicates that the 2 + 2 level of 204Hg is at least the main fragment of the 2 + 1,ms state. For the first time in this mass region, both lowest-lying, one-quadrupole phonon excitations are established together with the complete set of their decay strengths. In conclusion, this allows for a microscopic description of their structures, achieved in the framework of the Quasi-particle Phonon Model.« less

Reaction of β-blockers and β-agonist pharmaceuticals with aqueous chlorine. Investigation of kinetics and by-products by liquid chromatography quadrupole time-of-flight mass spectrometry.

PubMed

Quintana, José Benito; Rodil, Rosario; Cela, Rafael

2012-06-01

The degradation of two β-blockers (atenolol and propranolol) and one β-receptor agonist (salbutamol) during water chlorination was investigated by liquid chromatography-mass spectrometry (LC-MS). An accurate-mass quadrupole time-of-flight system (QTOF) was used to follow the time course of the pharmaceuticals and also used in the identification of the by-products. The degradation kinetics of these drugs was investigated at different concentrations of chlorine, bromide and sample pH by means of a Box-Behnken experimental design. Depending on these factors, dissipation half-lives varied in the ranges 68-145 h for atenolol, 1.3-33 min for salbutamol and 42-8362 min for propranolol. Normally, an increase in chlorine dosage and pH resulted in faster degradation of these pharmaceuticals. Moreover, the presence of bromide in water samples also resulted in a faster transformation of atenolol at low chlorine doses. The use of an accurate-mass high-resolution LC-QTOF-MS system permitted the identification of a total of 14 by-products. The transformation pathway of β-blockers/agonists consisted mainly of halogenations, hydroxylations and dealkylations. Also, many of these by-products are stable, depending on the chlorination operational parameters employed.

Characterization by high-performance liquid chromatography/electrospray ionization quadrupole time-of-flight mass spectrometry of the lipid fraction of Spirulina platensis pressurized ethanol extract.

PubMed

Herrero, Miguel; Vicente, María J; Cifuentes, Alejandro; Ibáñez, Elena

2007-01-01

Microalgae have been suggested as a potential source for new functional ingredients, making possible the development of new functional foods from natural origin. Among the natural ingredients, polyunsaturated fatty acids (PUFAs) have generally been identified as an interesting group of compounds with biological activity, mainly related to their anti-inflammatory properties. In this regard, the use of environmentally friendly extraction procedures (e.g. pressurized liquid extraction, PLE) to obtain such natural ingredients is also becoming necessary. In this work, an exhaustive characterization of the lipid fraction of a pressurized ethanolic extract of the microalga Spirulina platensis is carried out. To achieve this objective high-performance liquid chromatography (HPLC) coupled to quadrupole time-of-flight mass spectrometry (QTOF-MS) is employed. The use of the QTOF analyzer allows the selection and isolation of precursor ions as well as providing the high efficiency, sensitivity and mass accuracy required. By means of this powerful hyphenated technique, it was possible to identify several polar lipids in an extract of S. platensis (some of them, to our knowledge, described for the first time in this work), including four free fatty acids, four monogalactosyl monoacylglycerols, three phosphatidylglycerols and two sulfoquinovosyl diacylglycerols.

Determination of pesticide residues in animal origin baby foods by gas chromatography coupled with triple quadrupole mass spectrometry.

PubMed

Amendola, Graziella; Pelosi, Patrizia; Attard Barbini, Danilo

2015-01-01

A simple, fast and multiresidue method for the determination of pesticide residues in baby foods of animal origin has been developed in order to check the compliance with the Maximum Residue Levels (MRLs) set at a general value of 0.01 mg/kg by Commission Directive 2006/125/EC for infant foods. The main classes of organochlorine, organophosphorus and pyrethroid compounds have been considered, which are mainly fat soluble pesticides. The analytical procedure consists in the extraction of baby food samples by acetonitrile (ACN) followed by a clean up using C18 solid-phase extraction column eluted with ACN. The compounds were determined by gas chromatography-triple quadrupole mass spectrometry equipped with a Programmed Temperature Vaporizer (PTV) injection and a backflush system. In order to compensate for matrix effects PTV and matrix matched standard calibrations have been used. The method has been fully validated for 57 pesticides according to the Document SANCO/12571/2013. Accuracy and precision (repeatability) have been studied by recoveries at two spiking levels, the Limit of Quantitation (LOQ) (0.003-0.008 mg/kg) and 10 time greater (0.03-0.08 mg/kg), and the results were in the acceptable range of 70-120% with Relative Standards Deviations (RSD) ≤20%. Selectivity, linearity, LOQ and uncertainty of measurement were also determined for all the compounds. The method has been also applied for the analysis of 18 baby food animal origin samples, bought form the local market in Rome (Italy), and no pesticide in the scope of the method has been found above the MRL or the LOQ.

Tissue-specific metabolites profiling and quantitative analyses of flavonoids in the rhizome of Belamcanda chinensis by combining laser-microdissection with UHPLC-Q/TOF-MS and UHPLC-QqQ-MS.

PubMed

Chen, Yu Jie; Liang, Zhi Tao; Zhu, Yan; Xie, Guo Yong; Tian, Mei; Zhao, Zhong Zhen; Qin, Min Jian

2014-12-01

The rhizome of Belamcanda chinensis (L.) DC. is a traditionally used medicinal material in China. Due to increasing demand, B. chinensis has been cultivated widely, and thus the study on its rational utilization of medicinal part and guidelines for the optimal cultivation and harvest is an important issue. Considering flavonoids were the main bioactive secondary metabolites of B. chinensis, fluorescence microscopy, laser microdissection (LMD), ultra-high performance liquid chromatography-quadrupole/time-of-flight-mass spectrometry (UHPLC-Q/TOF-MS), and UHPLC coupled with triple quadrupole mass spectrometer (UHPLC-QqQ-MS) were applied to profile and determine flavonoids in various tissues in this study. Consequently, 43 peaks were detected by UHPLC-Q/TOF-MS, and 26 flavonoid compounds combined with seven triterpene compounds were identified or tentatively identified in the tissue extractions. The results indicated that the hydrophobic compounds, especially flavonoid or isoflavonoid aglycones and xanthone mainly accumulated in the cork, whereas the hydrophilic compounds, namely the flavonoid and isoflavonoid glycosides were usually found in the cortex or center (the part inside of endodermis). Samples of rhizomes from different growth ages and origins were simultaneously analyzed. It was shown that the bulb or lateral part of the rhizome generally possessed more total flavonoids than the vertical part or the primordium. The present study established a new practical method to evaluate the quality of the rhizome of B. chinensis and to explore the relationship between distribution patterns of secondary metabolites and growth years of plants, thus important information for cultivation and processing was provided. Copyright © 2014 Elsevier B.V. All rights reserved.

The large-scale microwave background anisotropy in decaying particle cosmology

NASA Technical Reports Server (NTRS)

Panek, Miroslaw

1988-01-01

The quadrupole anisotropy of the microwave background radiation in cosmological models with decaying particles is investigated. A conservative upper limit on value of the quadrupole moment combined with other constraints gives an upper limit on the redshift of the decay z(d) of less than 3-6.

Design and Test of a Liquid Oxygen / Liquid Methane Thruster with Cold Helium Pressurization Heat Exchanger

NASA Technical Reports Server (NTRS)

Melcher, John C.; Morehead, Robert L.; Atwell, Matthew J.; Hurlbert, Eric A.

2015-01-01

A liquid oxygen / liquid methane 2,000 lbf thruster was designed and tested in conjuction with a nozzle heat exchanger for cold helium pressurization. Cold helium pressurization systems offer significant spacecraft vehicle dry mass savings since the pressurant tank size can be reduced as the pressurant density is increased. A heat exchanger can be incorporated into the main engine design to provide expansion of the pressurant supply to the propellant tanks. In order to study the systems integration of a cold-helium pressurization system, a 2,000 lbf thruster with a nozzle heat exchanger was designed for integration into the Project Morpheus vehicle at NASA Johnson Space Center. The testing goals were to demonstrate helium loading and initial conditioning to low temperatures, high-pressure/low temperature storage, expansion through the main engine heat exchanger, and propellant tank injection/pressurization. The helium pressurant tank was an existing 19 inch diameter composite-overwrap tank, and the targert conditions were 4500 psi and -250 F, providing a 2:1 density advantage compared to room tempatrue storage. The thruster design uses like-on-like doublets in the injector pattern largely based on Project Morpheus main engine hertiage data, and the combustion chamber was designed for an ablative chamber. The heat exchanger was installed at the ablative nozzle exit plane. Stand-alone engine testing was conducted at NASA Stennis Space Center, including copper heat-sink chambers and highly-instrumented spoolpieces in order to study engine performance, stability, and wall heat flux. A one-dimensional thermal model of the integrated system was completed. System integration into the Project Morpheus vehicle is complete, and systems demonstrations will follow.

Efficient rotational cooling of Coulomb-crystallized molecular ions by a helium buffer gas.

PubMed

Hansen, A K; Versolato, O O; Kłosowski, L; Kristensen, S B; Gingell, A; Schwarz, M; Windberger, A; Ullrich, J; López-Urrutia, J R Crespo; Drewsen, M

2014-04-03

The preparation of cold molecules is of great importance in many contexts, such as fundamental physics investigations, high-resolution spectroscopy of complex molecules, cold chemistry and astrochemistry. One versatile and widely applied method to cool molecules is helium buffer-gas cooling in either a supersonic beam expansion or a cryogenic trap environment. Another more recent method applicable to trapped molecular ions relies on sympathetic translational cooling, through collisional interactions with co-trapped, laser-cooled atomic ions, into spatially ordered structures called Coulomb crystals, combined with laser-controlled internal-state preparation. Here we present experimental results on helium buffer-gas cooling of the rotational degrees of freedom of MgH(+) molecular ions, which have been trapped and sympathetically cooled in a cryogenic linear radio-frequency quadrupole trap. With helium collision rates of only about ten per second--that is, four to five orders of magnitude lower than in typical buffer-gas cooling settings--we have cooled a single molecular ion to a rotational temperature of 7.5(+0.9)(-0.7) kelvin, the lowest such temperature so far measured. In addition, by varying the shape of, or the number of atomic and molecular ions in, larger Coulomb crystals, or both, we have tuned the effective rotational temperature from about 7 kelvin to about 60 kelvin by changing the translational micromotion energy of the ions. The extremely low helium collision rate may allow for sympathetic sideband cooling of single molecular ions, and eventually make quantum-logic spectroscopy of buffer-gas-cooled molecular ions feasible. Furthermore, application of the present cooling scheme to complex molecular ions should enable single- or few-state manipulations of individual molecules of biological interest.

Pathways to Oxygen-Bearing Molecules in the Interstellar Medium and in Planetary Atmospheres: Cyclopropenone (c-C3H2O) and Propynal (HCCCHO)

NASA Astrophysics Data System (ADS)

Zhou, Li; Kaiser, Ralf I.; Gao, Li Gyun; Chang, Agnes H. H.; Liang, Mao-Chang; Yung, Yuk L.

2008-10-01

We investigated the formation of two C3H2O isomers, i.e., cyclopropenone (c-C3H2O) and propynal (HCCCHO), in binary ice mixtures of carbon monoxide (CO) and acetylene (C2H2) at 10 K in an ultrahigh vacuum machine on high-energy electron irradiation. The chemical evolution of the ice samples was followed online and in situ via a Fourier transform infrared spectrometer and a quadrupole mass spectrometer. The temporal profiles of the cyclopropenone and propynal isomers suggest (pseudo-) first-order kinetics. The cyclic structure (c-C3H2O) is formed via an addition of triplet carbon monoxide to ground-state acetylene (or vice versa); propynal (HCCCHO) can be synthesized from a carbon monoxide-acetylene complex via a [HCO...CCH] radical pair inside the matrix cage. These laboratory studies showed for the first time that both C3H2O isomers can be formed in low-temperature ices via nonequilibrium chemistry initiated by energetic electrons as formed in the track of Galactic cosmic ray particles penetrating interstellar icy grains in cold molecular clouds. Our results can explain the hitherto unresolved gas phase abundances of cyclopropenone in star-forming regions via sublimation of c-C3H2O as formed on icy grains in the cold molecular cloud stage. Implications for the heterogeneous oxygen chemistry of Titan and icy terrestrial planets and satellites suggest that the production of oxygen-bearing molecules such as C3H2O may dominate on aerosol particles compared to pure gas phase chemistry.

Complementary and alternative medicine for prevention and treatment of the common cold

PubMed Central

Nahas, Richard; Balla, Agneta

2011-01-01

Abstract Objective To review the evidence supporting complementary and alternative medicine approaches to treatment and prevention of the common cold in adults. Quality of Evidence MEDLINE, EMBASE, and the Cochrane Database of Systematic Reviews were searched from January 1966 to September 2009 combining the key words common cold or influenza with echinacea, garlic, ginseng, probiotics, vitamin C, and zinc. Clinical trials and prospective studies were included. Main Message For prevention, vitamin C demonstrated benefit in a large meta-analysis, with possibly increased benefit in patients subjected to cold stress. There is inconsistent evidence for Asian ginseng (Panax ginseng) and North American ginseng (Panax quinquefolius). Allicin was highly effective in 1 small trial. For treatment, Echinacea purpurea is the most consistently useful variety; it was effective in 5 of 6 trials. Zinc lozenges were effective in 5 of 9 trials, likely owing to dose and formulation issues. Overall, the evidence suggests no benefit from probiotics for prevention or treatment of the common cold. Conclusion Vitamin C can be recommended to Canadian patients for prevention of the common cold. There is moderate evidence supporting the use of Echinacea purpurea and zinc lozenges for treatment. Ginseng and allicin warrant further research. PMID:21322286

Study on site selection of cold chain logistics in northwest territories

NASA Astrophysics Data System (ADS)

Liu, Yubin; Ren, Zongwei

2017-08-01

In this research, we mainly studied the Site selection problem of cold chain logistics in northwest of China. In the first place, we counted the demands of cold chain products in northwest territories, and then classified it into the Site selection problem in five provinces in northwest territories(Xinjiang, Qinghai, Gansu, Ningxia, Shanxi); Next, we used the Center of gravity Method to select initial location; Finally, we established the location of distribution by using Analytic Hierarchy Process (AHP)and fuzzy comprehensive evaluation method. Comparing with the traditional method, this method not only considered the cost of transportation and distance, but also deliberated the physical condition, social environment and economics condition which associated with Site selection problem.

Use of ultra-high-pressure liquid chromatography-quadrupole time-of-flight MS to discover the presence of pesticide metabolites in food samples.

PubMed

Hernández, Félix; Grimalt, Susana; Pozo, Oscar J; Sancho, Juan V

2009-07-01

In this paper we illustrate the use of two different methodologies to investigate the presence of pesticide metabolites in parent pesticide-positive food samples, using ultra-high-pressure liquid chromatography coupled to hybrid quadrupole time-of-flight (UHPLC-QTOF) mass spectrometry. First, a common fragmentation pathway between the parent pesticide and its metabolites has been considered to search for metabolites in two positive market samples (imazalil in lemon, chlorpyrifos in grape). Secondly, olive oil samples from field residue trials were used for automated application of comparative software (MetaboLynx), which was used with treated and untreated samples to search for expected and unexpected metabolites of phosmet. One of the main objectives when using these approaches was to avoid the tedious manual searching for potential metabolites within the huge amount of information contained in the total ion chromatogram acquired by TOF MS. The common fragmentation approach applied to TOF MS full-acquisition data, considering an enhanced fragmentation in the collision cell, has allowed the discovery of two metabolites of imazalil (1-[2-(2,4-dichlorophenyl)-2-hydroxyethyl]-1H-imidazole and 1-[2-(2,4-dichlorophenyl)-2-oxoethyl]-1H-imidazole) in a lemon positive sample, as well as another two metabolites of chlorpyrifos (chlorpyrifos-oxon and 3,5,6-trichloro-2-pyridinol) in a grape positive sample. Moreover, MetaboLynx application to TOF MS data, without promoting fragmentation, from treated and untreated olive oil samples has been helpful in detecting the metabolite phosmet-oxon. In both strategies, every metabolite detected by TOF MS was confirmed using QTOF and/or triple quadrupole instruments. Accurate masses given by TOF MS together with the valuable information on product ions given by QTOF MS/MS experiments were crucial for the unambiguous identification of metabolites.

Doppler-Zeeman Mapping of the Rapidly Rotating Magnetic CP Star HD37776

NASA Astrophysics Data System (ADS)

Khokhlova, V. L.; Vasilchenko, D. V.; Stepanov, V. V.; Romanyuk, I. I.

2000-03-01

We present the results of our analysis of magnetic-field configuration and abundance anomalies on the surface of the rapidly rotating, chemically peculiar helium-strong variable B2 V star HD37776 with unresolved Zeeman components of spectral lines. Simultaneous inversion of the observed Stokes I and V profiles, which realizes the method of Doppler-Zeeman mapping (Vasilchenko et al. 1996), has been applied for the first time. Spectroscopic observations were carried out with the Main stellar spectrograph of the 6-m Special Astrophysical Observatory telescope equipped with a Zeeman analyzer and a CCD array, which allowed spectra in right- and left-hand circularly polarized light to be taken simultaneously at a signal-to-noise ratio S/N > 200 (Romanyuk et al. 1999). The profile width of winged spectral lines (reaching 5 A) is determined by Zeeman line splitting; however, the observed Zeeman components are blurred and unresolved because of the rapid stellar rotation. When solving the inverse problem, we sought for the magnetic-field configuration in the form of a combination of arbitrarily oriented dipole, quadrupole, and octupole placed at the stellar center. The observed Stokes I and V profiles for eight spectral lines of He, OII, AlIII, SiIII, and FeIII averaged over the visible stellar surface were used as input data. We constructed a model of the magnetic field from the condition of coincidence of magnetic maps obtained from different lines of different chemical elements and from the condition of a minimum profile residual. This model is a combination of centered coaxial dipole and quadrupole with the dominant quadrupole component at 30 deg < i < 50 deg, beta = 40 deg, and a maximum surface field strength H_s = 60 kG. A comparison of our abundance maps with the field configuration shows that the He concentration is at a maximum in the regions of maximum radial field, while the maximum concentrations of O, Al, Si, and Fe coincide with the regions of maximum tangential field.

Spatial distribution of cold-season lightning frequency in the coastal areas of the Sea of Japan

NASA Astrophysics Data System (ADS)

Tsurushima, Daiki; Sakaida, Kiyotaka; Honma, Noriyasu

2017-12-01

The coastal areas of the Sea of Japan are a well-known hotspot of winter lightning activity. This study distinguishes between three common types of winter lightning in that region (types A-C), based on their frequency distributions and the meteorological conditions under which they occur. Type A lightning occurs with high frequency in the Tohoku district. It is mainly caused by cold fronts that accompany cyclones passing north of the Japanese islands. Type B, which occurs most frequently in the coastal areas of the Hokuriku district, is mainly caused by topographically induced wind convergence and convective instability, both of which are associated with cyclones having multiple centers. Type C's lightning frequency distribution pattern is similar to that of type B, but its principal cause is a topographically induced wind convergence generated by cold air advection from the Siberian continent. Type A is most frequently observed from October to November, while types B and C tend to appear from November to January, consistent with seasonal changes in lightning frequency distribution in Japan's Tohoku and Hokuriku districts.

Evidence for Arctic Ozone Depletion in Late February and early March 1994

NASA Technical Reports Server (NTRS)

Manney, G. L.; Zurek, R. W.; Froidevaux, L.; Waters, J. W.

1995-01-01

Significant chemical ozone (O3 ) loss in the 1993-94 Arctic winter occurred mainly during an unusually late cold spell of approximately 10 days in late Feb/early Mar. Over the 30 d period studied (including the cold spell), observed vortex-averaged O3 at 465 K (approximately 40 hPa) decreased by approximately 10%. New three-dimensional, diabatic trajectory calculations show that this observed decrease represents only about half of the net chemical loss (approximately 20%) during the 30 day period. The resupply of lower stratospheric O3 by transport in Feb 1994 was considerably greater than in 1993, when transport masked only about a quarter of the chemical loss in Feb/Mar. The net estimated chemical loss over 30 days in 1994 was comparable to that over the same 30 days in 1993, but mainly occurred at a faster rate during the brief cold spell. These results highlight the impact of Arctic interannual variability on the relative roles of chemistry and dynamics in O3 evolution during recent Arctic winters.

Intermittent cold exposure enhances fat accumulation in mice.

PubMed

Yoo, Hyung Sun; Qiao, Liping; Bosco, Chris; Leong, Lok-Hei; Lytle, Nikki; Feng, Gen-Sheng; Chi, Nai-Wen; Shao, Jianhua

2014-01-01

Due to its high energy consuming characteristics, brown adipose tissue (BAT) has been suggested as a key player in energy metabolism. Cold exposure is a physiological activator of BAT. Intermittent cold exposure (ICE), unlike persistent exposure, is clinically feasible. The main objective of this study was to investigate whether ICE reduces adiposity in C57BL/6 mice. Surprisingly, we found that ICE actually increased adiposity despite enhancing Ucp1 expression in BAT and inducing beige adipocytes in subcutaneous white adipose tissue. ICE did not alter basal systemic insulin sensitivity, but it increased liver triglyceride content and secretion rate as well as blood triglyceride levels. Gene profiling further demonstrated that ICE, despite suppressing lipogenic gene expression in white adipose tissue and liver during cold exposure, enhanced lipogenesis between the exposure periods. Together, our results indicate that despite enhancing BAT recruitment, ICE in mice increases fat accumulation by stimulating de novo lipogenesis.

Intermittent Cold Exposure Enhances Fat Accumulation in Mice

PubMed Central

Yoo, Hyung sun; Qiao, Liping; Bosco, Chris; Leong, Lok-Hei; Lytle, Nikki; Feng, Gen-Sheng; Chi, Nai-Wen; Shao, Jianhua

2014-01-01

Due to its high energy consuming characteristics, brown adipose tissue (BAT) has been suggested as a key player in energy metabolism. Cold exposure is a physiological activator of BAT. Intermittent cold exposure (ICE), unlike persistent exposure, is clinically feasible. The main objective of this study was to investigate whether ICE reduces adiposity in C57BL/6 mice. Surprisingly, we found that ICE actually increased adiposity despite enhancing Ucp1 expression in BAT and inducing beige adipocytes in subcutaneous white adipose tissue. ICE did not alter basal systemic insulin sensitivity, but it increased liver triglyceride content and secretion rate as well as blood triglyceride levels. Gene profiling further demonstrated that ICE, despite suppressing lipogenic gene expression in white adipose tissue and liver during cold exposure, enhanced lipogenesis between the exposure periods. Together, our results indicate that despite enhancing BAT recruitment, ICE in mice increases fat accumulation by stimulating de novo lipogenesis. PMID:24789228

Hydrocarbon geochemistry of cold seeps in the Monterey Bay National Marine Sanctuary

USGS Publications Warehouse

Lorenson, T.D.; Kvenvolden, K.A.; Hostettler, F.D.; Rosenbauer, R.J.; Orange, D.L.; Martin, J.B.

2002-01-01

Samples from four geographically and tectonically discrete cold seeps named Clam Flat, Clamfield, Horseshoe Scarp South, and Tubeworm City, within the Monterey Bay National Marine Sanctuary were analyzed for their hydrocarbon content. The sediment contains gaseous hydrocarbons and CO2, as well as high molecular weight aliphatic and aromatic hydrocarbons with various combinations of thermogenic and biogenic contributions from petroleum, marine, and terrigenous sources. Of particular interest is the cold seep site at Clamfield which is characterized by the presence of thermogenic hydrocarbons including oil that can likely be correlated with oil-saturated strata at Majors Creek near Davenport, CA, USA. At Clam Flat, the evidence for thermogenic hydrocarbons is equivocal. At Horseshoe Scarp South and Tubeworm City, hydrocarbon gases, mainly methane, are likely microbial in origin. These varied sources of hydrocarbon gases highlight the diverse chemical systems that appear at cold seep communities. ?? 2002 Elsevier Science B.V. All rights reserved.

Biotechnological uses of enzymes from psychrophiles

PubMed Central

Cavicchioli, R.; Charlton, T.; Ertan, H.; Omar, S. Mohd; Siddiqui, K. S.; Williams, T. J.

2011-01-01

Summary The bulk of the Earth's biosphere is cold (e.g. 90% of the ocean's waters are ≤ 5°C), sustaining a broad diversity of microbial life. The permanently cold environments vary from the deep ocean to alpine reaches and to polar regions. Commensurate with the extent and diversity of the ecosystems that harbour psychrophilic life, the functional capacity of the microorganisms that inhabitat the cold biosphere are equally diverse. As a result, indigenous psychrophilic microorganisms provide an enormous natural resource of enzymes that function effectively in the cold, and these cold‐adapted enzymes have been targeted for their biotechnological potential. In this review we describe the main properties of enzymes from psychrophiles and describe some of their known biotechnological applications and ways to potentially improve their value for biotechnology. The review also covers the use of metagenomics for enzyme screening, the development of psychrophilic gene expression systems and the use of enzymes for cleaning. PMID:21733127

Cold storage of 'Manzanilla de Sevilla' and 'Manzanilla Cacereña' mill olives from super-high density orchards.

PubMed

Morales-Sillero, Ana; Pérez, Ana G; Casanova, Laura; García, José M

2017-12-15

The suitability of the cold storage (2°C) of fruit to maintain the quality of 'Manzanilla de Sevilla' and 'Manzanilla Cacereña' intended for virgin olive oil extraction was investigated. This temperature was effective in keeping the best commercial category of oil quality in both manually harvested olives and in mechanically harvested 'Manzanilla Cacereña' fruits for 11days. Mechanical harvesting induced significant decreases in oxidative stability and in the main phenolic compounds contents in the oils during cold storage and, only initially, in the total volatiles, regardless of the cultivar considered. However, the contents of volatile esters, associated to fruity flavor, were always higher in the oils from mechanically harvested fruits. 'Manzanilla de Sevilla' oils exhibited higher total volatiles during fruit cold storage, regardless of the harvesting system used. Copyright © 2017 Elsevier Ltd. All rights reserved.

Implementation of cold risk management in occupational safety, occupational health and quality practices. Evaluation of a development process and its effects at the finnish maritime administration.

PubMed

Risikko, Tanja; Remes, Jouko; Hassi, Juhani

2008-01-01

Cold is a typical environmental risk factor in outdoor work in northern regions. It should be taken into account in a company's occupational safety, health and quality systems. A development process for improving cold risk management at the Finnish Maritime Administration (FMA) was carried out by FMA and external experts. FMA was to implement it. Three years after the development phase, the outcomes and implementation were evaluated. The study shows increased awareness about cold work and few concrete improvements. Concrete improvements in occupational safety and health practices could be seen in the pilot group. However, organization-wide implementation was insufficient, the main reasons being no organization-wide practices, unclear process ownership, no resources and a major reorganization process. The study shows a clear need for expertise supporting implementation. The study also presents a matrix for analyzing the process.

[Strategies and mechanisms of soil springtails in adapting lower temperature environment: research progress].

PubMed

Liu, Jing; Wang, Yun-Biao; Wu, Dong-Hui

2012-12-01

Low temperature and drought are the main environmental factors threatening the animals living in arctic area and cold temperate regions. To adapt the severe environment, the animals should adopt appropriate strategies. As a group of arthopods with freeze-avoiding strategy, soil springtails have the similar ecological mechanisms and modes of cold resistance/tolerance as insects, manifesting in the cold acclimation and drought tolerance to decrease the damage of ice crystal formation. During cold acclimation, there are a rapid increase of glycerol, a rapid decrease of fucose and glucose, and the production of anti-freeze proteins (AFP) , and exists the inter-transformation of different kinds of lipids to improve the flow of cell membrane to protect the cell from low temperature injury. In addition, soil springtails have their own specific modes and mechanisms to tolerate low temperature stress, mainly the vertical migration under the protection of snow cover and the excretion of ice nucleator from haemolymph, illustrating that it's of significance to research the cryobiology of soil springtails. This paper summarized the modes and mechanisms of soil springtails in tolerating low temperature environment, reviewed the research progress on the eco-physiology of the springtails, discussed the existing problems of the researches on the low temperature tolerance of the springtails, and prospected the research directions of the springtails low temperature ecology under the background of global change.

The MQXA quadrupoles for the LHC low-beta insertions

NASA Astrophysics Data System (ADS)

Ajima, Y.; Higashi, N.; Iida, M.; Kimura, N.; Nakamoto, T.; Ogitsu, T.; Ohhata, H.; Ohuchi, N.; Shintomi, T.; Sugawara, S.; Sugita, K.; Tanaka, K.; Taylor, T.; Terashima, A.; Tsuchiya, K.; Yamamoto, A.

2005-09-01

High-performance superconducting quadrupole magnets, MQXA, for the LHC low-beta insertions have been designed, manufactured in series and tested. The design field gradient of the quadrupole, which has a coil aperture of diameter 70 mm, was 240 T/m at 1.9 K; its effective length is 6.37 m, and it is required to operate reliably at up to 215 T/m when subjected to radiation heat deposit in the coils of up to 5 W/m. The series of 20 magnets has been produced in industry, and tested at KEK. The magnet design is explained, and the construction and performance of the series units, in terms of training, field quality and geometry, are presented.

Air broadening of the hydrogen halides. I - N2-broadening and shifting in the HCl fundamental

NASA Technical Reports Server (NTRS)

Looney, J. P.; Herman, R. M.

1987-01-01

The resolvent operator formalism of Kolb, Griem (1964), and Baranger (1962) is used to determine the widths and shifts of the fundamental band vibration-rotation lines of HCl under N2 pressure. Time-development operator matrix elements are evaluated accounting for all bilinear and second order anisotropic terms, in addition to isotropic effects to all orders. The method employs the use of a parabolic trajectory model and explicit velocity averaging. The major contributions to the linewidths are found to arise from dipole-quadrupole, quadrupole-quadrupole, and vibrationally dependent isotropic dispersion forces. Good overall agreement is found between calculated and measured widths and linewidths over a 163-295 K temperature range.

The quadrupole moments of some even–even nuclei around the mass of A ~ 80: {sup 68−80}Ge on the neighborhood of {sup 76−84}Kr and {sup 76−84}Se isotopes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yoruk, Abdulkadir, E-mail: yorukabdulkadir@hotmail.com; Turkan, Nureddin, E-mail: nureddin.turkan@medeniyet.edu.tr

2016-09-15

We have carried out the calculation of the quadrupole moments Q(2{sub 1}{sup +}) and electromagnetic transition rates B(E2) of some levels within the framework of the interacting boson model for even-mass Ge nuclei. The presented predictions of the quadrupole moments and B(E2) ratios for Ge nuclei are compared with the results of some previous experimental and theoretical ones along with those of the neighboring Kr and Se isotopes and then it was seen that they agree well with the previous experimental and theoretical ones.

The argon nuclear quadrupole moments

NASA Astrophysics Data System (ADS)

Sundholm, Dage; Pyykkö, Pekka

2018-07-01

New standard values -116(2) mb and 76(3) mb are suggested for the nuclear quadrupole moments (Q) of the 39Ar and 37Ar nuclei, respectively. The Q values were obtained by combining optical measurements of the quadrupole coupling constant (B or eqQ/h) of the 3s23p54s[3/2]2 (3Po) and 3s23p54p[5/2]3 (3De) states of argon with large scale numerical complete active space self-consistent field and restricted active space self-consistent field calculations of the electric field gradient at the nucleus (q) using the LUCAS code, which is a finite-element based multiconfiguration Hartree-Fock program for atomic structure calculations.

Low-frequency quadrupole impedance of undulators and wigglers

DOE PAGES

Blednykh, A.; Bassi, G.; Hidaka, Y.; ...

2016-10-25

An analytical expression of the low-frequency quadrupole impedance for undulators and wigglers is derived and benchmarked against beam-based impedance measurements done at the 3 GeV NSLS-II storage ring. The adopted theoretical model, valid for an arbitrary number of electromagnetic layers with parallel geometry, allows to calculate the quadrupole impedance for arbitrary values of the magnetic permeability μ r. Here, in the comparison of the analytical results with the measurements for variable magnet gaps, two limit cases of the permeability have been studied: the case of perfect magnets (μ r → ∞), and the case in which the magnets are fullymore » saturated (μ r = 1).« less

RFQ device for accelerating particles

DOEpatents

Shepard, Kenneth W.; Delayen, Jean R.

1995-01-01

A superconducting radio frequency quadrupole (RFQ) device includes four spaced elongated, linear, tubular rods disposed parallel to a charged particle beam axis, with each rod supported by two spaced tubular posts oriented radially with respect to the beam axis. The rod and post geometry of the device has four-fold rotation symmetry, lowers the frequency of the quadrupole mode below that of the dipole mode, and provides large dipole-quadrupole mode isolation to accommodate a range of mechanical tolerances. The simplicity of the geometry of the structure, which can be formed by joining eight simple T-sections, provides a high degree of mechanical stability, is insensitive to mechanical displacement, and is particularly adapted for fabrication with superconducting materials such as niobium.

Electron radiography

DOEpatents

Merrill, Frank E.; Morris, Christopher

2005-05-17

A system capable of performing radiography using a beam of electrons. Diffuser means receive a beam of electrons and diffuse the electrons before they enter first matching quadrupoles where the diffused electrons are focused prior to the diffused electrons entering an object. First imaging quadrupoles receive the focused diffused electrons after the focused diffused electrons have been scattered by the object for focusing the scattered electrons. Collimator means receive the scattered electrons and remove scattered electrons that have scattered to large angles. Second imaging quadrupoles receive the collimated scattered electrons and refocus the collimated scattered electrons and map the focused collimated scattered electrons to transverse locations on an image plane representative of the electrons' positions in the object.

Intra-seasonal Characteristics of Wintertime Extreme Cold Events over South Korea

NASA Astrophysics Data System (ADS)

Park, Taewon; Jeong, Jeehoon; Choi, Jahyun

2017-04-01

The present study reveals the changes in the characteristics of extreme cold events over South Korea for boreal winter (November to March) in terms of the intra-seasonal variability of frequency, duration, and atmospheric circulation pattern. Influences of large-scale variabilities such as the Siberian High activity, the Arctic Oscillation (AO), and the Madden-Julian Oscillation (MJO) on extreme cold events are also investigated. In the early and the late of the winter during November and March, the upper-tropospheric wave-train for a life-cycle of the extreme cold events tends to pass quickly over East Asia. In addition, compared with the other months, the intensity of the Siberian High is weaker and the occurrences of strong negative AO are less frequent. It lead to events with weak amplitude and short duration. On the other hand, the amplified Siberian High and the strong negative AO occur more frequently in the mid of the winter from December to February. The extreme cold events are mainly characterized by a well-organized anticyclonic blocking around the Ural Mountain and the Subarctic. These large-scale circulation makes the extreme cold events for the midwinter last long with strong amplitude. The MJO phases 2-3 which provide a suitable condition for the amplification of extreme cold events occur frequently for November to January when the frequencies are more than twice those for February and March. While the extreme cold events during March have the least frequency, the weakest amplitude, and the shortest duration due to weak impacts of the abovementioned factors, the strong activities of the factors for January force the extreme cold events to be the most frequent, the strongest, and the longest among the boreal winter. Keywords extreme cold event, wave-train, blocking, Siberian High, AO, MJO

Improvements in Cold-Plate Fabrication

NASA Technical Reports Server (NTRS)

Zaffetti, Mark A.; Taddey, Edmund P.; Laurin, Michael B.; Chabebe, Natalia

2012-01-01

Five improvements are reported in cold-plate fabrication. This cold plate is part of a thermal control system designed to serve on space missions. The first improvement is the merging of the end sheets of the cold plate with the face sheets of the structural honeycomb panel. The cold plate, which can be a brazed assembly, uses the honeycomb face sheet as its end sheet. Thus, when the honeycomb panel is fabricated, the face sheet that is used is already part of the cold plate. In addition to reducing weight, costs, and steps, the main benefit of this invention is that it creates a more structurally sound assembly. The second improvement involves incorporation of the header into the closure bar to pass the fluid to a lower layer. Conventional designs have used a separate header, which increases the geometry of the system. The improvement reduces the geometry, thus allowing the cold plate to fit into smaller area. The third improvement eliminates the need of hose, tube, or manifold to supply the cooling fluid externally. The external arrangement can be easily damaged and is vulnerable to leakage. The new arrangement incorporates an internal fluid transfer tube. This allows the fluid to pass from one cold plate to the other without any exposed external features. The fourth improvement eliminates separate fabrication of cold plate(s) and structural members followed by a process of attaching them to each other. Here, the structural member is made of material that can be brazed just as that of the cold plate. Now the structural member and the cold plate can be brazed at the same time, creating a monolithic unit, and thus a more structurally sound assembly. Finally, the fifth improvement is the elimination of an additional welding step that can damage the braze joints. A tube section, which is usually welded on after the braze process, is replaced with a more structurally sound configuration that can be brazed at the same time as the rest of the cold plate.

a Fascinating Two-Photon Process: Magnetically Induced Quadrupole Second Harmonic Genaration

NASA Astrophysics Data System (ADS)

Matsuoka, Masahiro

1990-10-01

After a short prologue, recalling the memory of the first meeting with Professor Bloembergen, the author reviews a topic of a second harmonic generation in centrosymmetric medium, that is, magnetically induced quadrupole SHG. A pictorial description of the process is presented together with a few suggestions for future experiment.

Calculation of total cross sections for charge exchange in molecular collisions

NASA Technical Reports Server (NTRS)

Ioup, J.

1979-01-01

Areas of investigation summarized include nitrogen ion-nitrogen molecule collisions; molecular collisions with surfaces; molecular identification from analysis of cracking patterns of selected gases; computer modelling of a quadrupole mass spectrometer; study of space charge in a quadrupole; transmission of the 127 deg cylindrical electrostatic analyzer; and mass spectrometer data deconvolution.

Electrodynamic Aerosol Concentrating and Sampling

DTIC Science & Technology

2006-06-16

flat-plate AC electrode ...................................................................................................9 Figure 4. Corona needle ...Figure 4 shows a fine hypodermic needle used as a corona wire within the first quadrupole. The quadrupole electrodes would serve as the collecting...carefully expanded to better approximate hyperbolas. It is shown here with the inner needle corona electrode in place. Once it was determined that the

Evaluation of Diversity Based on Morphological Variabilities and ISSR Molecular Markers in Iranian Cynodon dactylon (L.) Pers. Accessions to Select and Introduce Cold-Tolerant Genotypes.

PubMed

Akbari, M; Salehi, H; Niazi, A

2018-04-01

The main goals of the present study were to screen Iranian common bermudagrasses to find cold-tolerant accessions and evaluate their genetic and morphological variabilities. In this study, 49 accessions were collected from 18 provinces of Iran. One foreign cultivar of common bermudagrass was used as control. Morphological variation was evaluated based on 14 morphological traits to give information about taxonomic position of Iranian common bermudagrass. Data from morphological traits were evaluated to categorize all accessions as either cold sensitive or tolerant using hierarchical clustering with Ward's method in SPSS software. Inter-Simple Sequence Repeat (ISSR) primers were employed to evaluate genetic variability of accessions. The results of our taxonomic investigation support the existence of two varieties of Cynodon dactylon in Iran: var. dactylon (hairless plant) and var. villosous (plant with hairs at leaf underside and/or upper side surfaces or exterior surfaces of sheath). All 15 primers amplified and gave clear and highly reproducible DNA fragments. In total, 152 fragments were produced, of which 144 (94.73%) being polymorphic. The polymorphic information content (PIC) values ranged from 0.700 to 0.928. The average PIC value obtained with 15 ISSR primers was 0.800, which shows that all primers were informative. Probability identity (PI) and discriminating power between all primers ranged from 0.029 to 0.185 and 0.815 to 0.971, respectively. Genetic data were converted into a binary data matrix. NTSYS software was used for data analysis. Clustering was done by the unweighted pair-group method with arithmetic averages and principle coordinate analysis, separated the accessions into six main clusters. According to both morphological and genetic diversity investigations of accessions, they can be clustered into three groups: cold sensitive, cold semi-tolerant, and cold tolerant. The most cold-tolerant accessions were: Taft, Malayear, Gorgan, Safashahr, Naein, Aligoudarz, and the foreign cultivar. This study may provide useful information for further breeding programs on common bermudagrass. Selected genotypes can be evaluated for other abiotic stresses such as drought and salinity.

Main processes of the Atlantic cold tongue interannual variability

NASA Astrophysics Data System (ADS)

Planton, Yann; Voldoire, Aurore; Giordani, Hervé; Caniaux, Guy

2018-03-01

The interannual variability of the Atlantic cold tongue (ACT) is studied by means of a mixed-layer heat budget analysis. A method to classify extreme cold and warm ACT events is proposed and applied to ten various analysis and reanalysis products. This classification allows 5 cold and 5 warm ACT events to be selected over the period 1982-2007. Cold (warm) ACT events are defined by the presence of negative (positive) sea surface temperature (SST) anomalies at the center of the equatorial Atlantic in late boreal spring, preceded by negative (positive) zonal wind stress anomalies in the western equatorial Atlantic. An ocean general circulation model capable of reconstructing the interannual variability of the ACT correctly is used to demonstrate that cold ACT events develop rapidly from May to June mainly due to intense cooling by vertical mixing and horizontal advection. The simulated cooling at the center of the basin is the result of the combined effects of non-local and local processes. The non-local process is an upwelling associated with an eastward-propagating Kelvin wave, which makes the mixed-layer more shallow and preconditions the upper layers to be cooled by an intense heat loss at the base of the mixed-layer, which is amplified by a stronger local injection of energy from the atmosphere. The early cooling by vertical mixing in March is also shown to be a good predictor of June cooling. In July, horizontal advection starts to warm the mixed-layer abnormally and damps SST anomalies. The advection anomalies, which result from changes in the horizontal temperature gradient, are associated in some cases with the propagation of Rossby waves along the equator. During warm ACT events, processes are reversed, generating positive SST anomalies: a downwelling Kelvin wave triggers stratification anomalies and mixed-layer depth anomalies, amplified by a weaker injection of energy from the atmosphere in May-June. In July, warm ACT events are abnormally cooled due to negative horizontal advection anomalies resulting from processes similar to those that occur during cold ACT events. This additional cooling process extends the period of cooling of the ACT, reducing SST anomalies.

Multi-elemental analysis of aqueous geochemical samples by quadrupole inductively coupled plasma-mass spectrometry (ICP-MS)

USGS Publications Warehouse

Wolf, Ruth E.; Adams, Monique

2015-01-01

Typically, quadrupole inductively coupled plasma-mass spectrometry (ICP-MS) is used to determine as many as 57 major, minor, and trace elements in aqueous geochemical samples, including natural surface water and groundwater, acid mine drainage water, and extracts or leachates from geological samples. The sample solution is aspirated into the inductively coupled plasma (ICP) which is an electrodeless discharge of ionized argon gas at a temperature of approximately 6,000 degrees Celsius. The elements in the sample solution are subsequently volatilized, atomized, and ionized by the ICP. The ions generated are then focused and introduced into a quadrupole mass filter which only allows one mass to reach the detector at a given moment in time. As the settings of the mass analyzer change, subsequent masses are allowed to impact the detector. Although the typical quadrupole ICP-MS system is a sequential scanning instrument (determining each mass separately), the scan speed of modern instruments is on the order of several thousand masses per second. Consequently, typical total sample analysis times of 2–3 minutes are readily achievable for up to 57 elements.

Evaluation of asymmetric quadrupoles for a non-scaling fixed field alternating gradient accelerator

NASA Astrophysics Data System (ADS)

Lee, Sang-Hun; Park, Sae-Hoon; Kim, Yu-Seok

2017-12-01

A non-scaling fixed field alternating gradient (NS-FFAG) accelerator was constructed, which employs conventional quadrupoles. The possible demerit is the beam instability caused by the variable focusing strength when the orbit radius of the beam changes. To overcome this instability, it was suggested that the asymmetric quadrupole has different current flows in each coil. The magnetic field of the asymmetric quadrupole was found to be more similar to the magnetic field required for the FFAG accelerator than the constructed NS-FFAG accelerator. In this study, a simulation of the beam dynamics was carried out to evaluate the improvement to the beam stability for the NS-FFAG accelerator using the SIMION program. The beam dynamics simulation was conducted with the `hard edge' model; it ignored the fringe field at the end of the magnet. The magnetic field map of the suggested magnet was created using the SIMION program. The lattices for the simulation combined the suggested magnets. The magnets were evaluated for beam stability in the lattices through the SIMION program.

Phenolic profiling of the skin, pulp and seeds of Albariño grapes using hybrid quadrupole time-of-flight and triple-quadrupole mass spectrometry.

PubMed

Di Lecce, Giuseppe; Arranz, Sara; Jáuregui, Olga; Tresserra-Rimbau, Anna; Quifer-Rada, Paola; Lamuela-Raventós, Rosa M

2014-02-15

This paper describes for the first time a complete characterisation of the phenolic compounds in different anatomical parts of the Albariño grape. The application of high-performance liquid chromatography coupled with two complementary techniques, hybrid quadrupole time-of-flight and triple-quadrupole mass spectrometry, allowed the phenolic composition of the Albariño grape to be unambiguously identified and quantified. A more complete phenolic profile was obtained by product ion and precursor ion scans, while a neutral loss scan at 152 u enabled a fast screening of procyanidin dimers, trimers and their galloylated derivatives. The compounds were confirmed by accurate mass measurements in QqToF-MS and QqToF-MS/MS modes at high resolution, and good fits were obtained for all investigated ions, with errors ranging from 0.2 to 4.5 mDa. To the best of our knowledge, two flavanol monomer hexosides were detected in the grape berry for the first time. Copyright © 2013 Elsevier Ltd. All rights reserved.

Electric quadrupole moment of the 5d {sup 2}D{sub 3/2} state in {sup 171}Yb{sup +}: A relativistic coupled-cluster analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Latha, K. V. P.; Chaudhuri, R. K.; Das, B. P.

2007-12-15

The electric quadrupole moment for the 5d {sup 2}D{sub 3/2} state of {sup 171}Yb{sup +}, has been calculated using the relativistic coupled-cluster method. Earlier a similar calculation was performed for the 4d {sup 2}D{sub 5/2} state of {sup 88}Sr{sup +} which is the most accurate determination to date [Sur et al., Phys. Rev. Lett. 96, 193001 (2006)]. The present calculation of the electric quadrupole moment of {sup 171}Yb{sup +} yielded a value 2.157ea{sub 0}{sup 2} where the experimental value is 2.08(11)ea{sub 0}{sup 2}; a{sub 0} is the Bohr radius and e the elementary charge. We discuss in this paper ourmore » results for {sup 171}Yb{sup +} in detail and highlight the dominant correlation effects present. We have presented the effect of inner core excitations and their contribution to the electric quadrupole moment, which is a property sensitive to regions away from the nucleus.« less

Dynamic quadrupole interactions in semiconductors

NASA Astrophysics Data System (ADS)

Dang, Thien Thanh; Schell, Juliana; Lupascu, Doru C.; Vianden, Reiner

2018-04-01

The time differential perturbed angular correlation, TDPAC, technique has been used for several decades to study electric quadrupole hyperfine interactions in semiconductors such as dynamic quadrupole interactions (DQI) resulting from after-effects of the nuclear decay as well as static quadrupole interactions originating from static defects around the probe nuclei such as interstitial ions, stresses in the crystalline structure, and impurities. Nowadays, the quality of the available semiconductor materials is much better, allowing us to study purely dynamic interactions. We present TDPAC measurements on pure Si, Ge, GaAs, and InP as a function of temperature between 12 K and 110 K. The probe 111In (111Cd) was used. Implantation damage was recovered by thermal annealing. Si experienced the strongest DQI with lifetime, τg, increasing with rising temperature, followed by Ge. In contrast, InP and GaAs, which have larger band gaps and less electron concentration than Si and Ge in the same temperature range, presented no DQI. The results obtained also allow us to conclude that indirect band gap semiconductors showed the dynamic interaction, whereas the direct band gap semiconductors, restricted to GaAs and InP, did not.

Tolerance analyses of a quadrupole magnet for advanced photon source upgrade

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, J., E-mail: Jieliu@aps.anl.gov; Jaski, M., E-mail: jaski@aps.anl.gov; Borland, M., E-mail: borland@aps.anl.gov

2016-07-27

Given physics requirements, the mechanical fabrication and assembly tolerances for storage ring magnets can be calculated using analytical methods [1, 2]. However, this method is not easy for complicated magnet designs [1]. In this paper, a novel method is proposed to determine fabrication and assembly tolerances consistent with physics requirements, through a combination of magnetic and mechanical tolerance analyses. In this study, finite element analysis using OPERA is conducted to estimate the effect of fabrication and assembly errors on the magnetic field of a quadrupole magnet and to determine the allowable tolerances to achieve the specified magnetic performances. Based onmore » the study, allowable fabrication and assembly tolerances for the quadrupole assembly are specified for the mechanical design of the quadrupole magnet. Next, to achieve the required assembly level tolerances, mechanical tolerance stackup analyses using a 3D tolerance analysis package are carried out to determine the part and subassembly level fabrication tolerances. This method can be used to determine the tolerances for design of other individual magnets and of magnet strings.« less

The long-range non-additive three-body dispersion interactions for the rare gases, alkali, and alkaline-earth atoms

NASA Astrophysics Data System (ADS)

Tang, Li-Yan; Yan, Zong-Chao; Shi, Ting-Yun; Babb, James F.; Mitroy, J.

2012-03-01

The long-range non-additive three-body dispersion interaction coefficients Z111, Z112, Z113, and Z122 are computed for many atomic combinations using standard expressions. The atoms considered include hydrogen, the rare gases, the alkali atoms (up to Rb), and the alkaline-earth atoms (up to Sr). The term Z111 arising from three mutual dipole interactions is known as the Axilrod-Teller-Muto coefficient or the DDD (dipole-dipole-dipole) coefficient. Similarly, the terms Z112, Z113, and Z122 arise from the mutual combinations of dipole (1), quadrupole (2), and octupole (3) interactions between atoms and they are sometimes known, respectively, as dipole-dipole-quadrupole, dipole-dipole-octupole, and dipole-quadrupole-quadrupole coefficients. Results for the four Z coefficients are given for the homonuclear trimers, for the trimers involving two like-rare-gas atoms, and for the trimers with all combinations of the H, He, and Li atoms. An exhaustive compilation of all coefficients between all possible atomic combinations is presented as supplementary data.

Simulation of Thermographic Responses of Delaminations in Composites with Quadrupole Method

NASA Technical Reports Server (NTRS)

Winfree, William P.; Zalameda, Joseph N.; Howell, Patricia A.; Cramer, K. Elliott

2016-01-01

The application of the quadrupole method for simulating thermal responses of delaminations in carbon fiber reinforced epoxy composites materials is presented. The method solves for the flux at the interface containing the delamination. From the interface flux, the temperature at the surface is calculated. While the results presented are for single sided measurements, with ash heating, expansion of the technique to arbitrary temporal flux heating or through transmission measurements is simple. The quadrupole method is shown to have two distinct advantages relative to finite element or finite difference techniques. First, it is straight forward to incorporate arbitrary shaped delaminations into the simulation. Second, the quadrupole method enables calculation of the thermal response at only the times of interest. This, combined with a significant reduction in the number of degrees of freedom for the same simulation quality, results in a reduction of the computation time by at least an order of magnitude. Therefore, it is a more viable technique for model based inversion of thermographic data. Results for simulations of delaminations in composites are presented and compared to measurements and finite element method results.

Final 6D Muon Ionization Colling using Strong Focusing Quadrupoles

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hart, T. L.; Acosta, J. G.; Cremaldi, L. M.

2016-11-15

Abstract Low emittance muon beam lines and muon colliders are potentially a rich source of BSM physics for future exper- imenters. A muon beam normalized emittance of ax,y,z = (280, 280, 1570)µm has been achieved in simulation with short solenoids and a betatron function of 3 cm. Here we use ICOOL and MAD-X to explore using a 400 MeV/c muon beam and strong focusing quadrupoles to achieve a normalized transverse emittance of 100 µm and complete 6D cooling. The low beta regions, as low as 5 mm, produced by the quadrupoles are occupied by dense, low Z absorbers, such asmore » lithium hydride or beryllium, that cool the beam transversely. Equilibrium transverse emittance is linearly proportional to the transverse betatron function. Reverse emittance exchange with septa and/or wedges is then used to decrease transverse emittance from 100 to 25 µm at the expense of longitudinal emittance for a high energy lepton collider. Cooling challenges include chromaticity correction, ssband overlap, quadrupole acceptance, and staying in phase with RF.« less

Temporal and spatial variations of sea surface temperature in the East China Sea

NASA Astrophysics Data System (ADS)

Tseng, Chente; Lin, Chiyuan; Chen, Shihchin; Shyu, Chungzen

2000-03-01

Sea surface temperature of the East China Sea (ECS) were analyzed using the NOAA/AVHRR SST images. These satellite images reveal surface features of ECS including mainly the Kuroshio Current, Kuroshio Branch Current, Taiwan Warm Current, China coastal water, Changjiang diluted water and Yellow Sea mixed cold water. The SST of ECS ranges from 27 to 29°C in summer; some cold eddies were found off northeast Taiwan and to the south of Changjiang mouth. SST anomalies at the center of these eddies were about 2-5°C. The strongest front usually occurs in May each year and its temperature gradient is about 5-6°C over a cross-shelf distance of 30 nautical miles. The Yellow Sea mixed cold water also provides a contrast from China Coastal waters shoreward of the 50 m isobath; cross-shore temperature gradient is about 6-8°C over 30 nautical miles. The Kuroshio intrudes into ECS preferably at two locations. The first is off northeast Taiwan; the subsurface water of Kuroshio is upwelled onto the shelf while the main current is deflected seaward. The second site is located at 31°N and 128°E, which is generally considered as the origin of the Tsushima Warm Current. More quantitatively, a 2-year time series of monthly SST images is examined using EOF analysis to determine the spatial and temporal variations in the northwestern portion of ECS. The first spatial EOF mode accounts for 47.4% of total spatial variance and reveals the Changjiang plume and coastal cold waters off China. The second and third EOF modes account for 16.4 and 9.6% of total variance, respectively, and their eigenvector images show the intrusion of Yellow Sea mixed cold waters and the China coastal water. The fourth EOF mode accounts for 5.4% of total variance and reveals cold eddies around Chusan Islands. The temporal variance EOF analysis is less revealing in this study area.

Prediction of thermodynamic properties of coal derivatives. Progress report, September 1, 1981-August 31, 1982

DOE Office of Scientific and Technical Information (OSTI.GOV)

Donohue, M.D.

It is the purpose of this research program to develop a model to predict the thermodynamic properties of coal derivatives. Unlike natural gas and petroleum, coal and its gasification and liquefaction products are predominantly aromatic and have substantial quadrupole moments. Because of these quadrupole forces, the numerous correlational techniques that have been developed for petroleum products cannot be used to predict the thermodynamic properties of coal derivatives. We are presently developing a correlation that will be useful in predicting the thermodynamic properties of coal derivatives. This theory is based on the Perturbed-Hard-Chain theory, but is different from PHCT in twomore » respects. First, PHCT uses a square-well to describe the intermolecular potential energy between two molecules. In our new theory, the Lennard-Jones potential energy function is used. The second difference is that we take into account the effect of quadrupole forces on the intermolecular potential energy. In PHCT these forces were ignored. In PHCT the contributions to the partition function (or equation of state) that arise from the attractive forces between molecules (regardless of whether these forces are treated as a square-well or by Lennard-Jones) are calculated by assuming that they are perturbations on a hard sphere. In calculating the contributions to the partition function that arise from the quadrupole-quadrupole interactions, we use a second order perturbation about the Lennard-Jones. For aromatic molecules, the effect of this additional perturbation is significant.« less

A TREND BETWEEN COLD DEBRIS DISK TEMPERATURE AND STELLAR TYPE: IMPLICATIONS FOR THE FORMATION AND EVOLUTION OF WIDE-ORBIT PLANETS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ballering, Nicholas P.; Rieke, George H.; Su, Kate Y. L.

2013-09-20

Cold debris disks trace the limits of planet formation or migration in the outer regions of planetary systems, and thus have the potential to answer many of the outstanding questions in wide-orbit planet formation and evolution. We characterized the infrared excess spectral energy distributions of 174 cold debris disks around 546 main-sequence stars observed by both the Spitzer Infrared Spectrograph and the Multiband Imaging Photometer for Spitzer. We found a trend between the temperature of the inner edges of cold debris disks and the stellar type of the stars they orbit. This argues against the importance of strictly temperature-dependent processesmore » (e.g., non-water ice lines) in setting the dimensions of cold debris disks. Also, we found no evidence that delayed stirring causes the trend. The trend may result from outward planet migration that traces the extent of the primordial protoplanetary disk, or it may result from planet formation that halts at an orbital radius limited by the efficiency of core accretion.« less

Targeted Proteomic Quantification on Quadrupole-Orbitrap Mass Spectrometer*

PubMed Central

Gallien, Sebastien; Duriez, Elodie; Crone, Catharina; Kellmann, Markus; Moehring, Thomas; Domon, Bruno

2012-01-01

There is an immediate need for improved methods to systematically and precisely quantify large sets of peptides in complex biological samples. To date protein quantification in biological samples has been routinely performed on triple quadrupole instruments operated in selected reaction monitoring mode (SRM), and two major challenges remain. Firstly, the number of peptides to be included in one survey experiment needs to be increased to routinely reach several hundreds, and secondly, the degree of selectivity should be improved so as to reliably discriminate the targeted analytes from background interferences. High resolution and accurate mass (HR/AM) analysis on the recently developed Q-Exactive mass spectrometer can potentially address these issues. This instrument presents a unique configuration: it is constituted of an orbitrap mass analyzer equipped with a quadrupole mass filter as the front-end for precursor ion mass selection. This configuration enables new quantitative methods based on HR/AM measurements, including targeted analysis in MS mode (single ion monitoring) and in MS/MS mode (parallel reaction monitoring). The ability of the quadrupole to select a restricted m/z range allows one to overcome the dynamic range limitations associated with trapping devices, and the MS/MS mode provides an additional stage of selectivity. When applied to targeted protein quantification in urine samples and benchmarked with the reference SRM technique, the quadrupole-orbitrap instrument exhibits similar or better performance in terms of selectivity, dynamic range, and sensitivity. This high performance is further enhanced by leveraging the multiplexing capability of the instrument to design novel acquisition methods and apply them to large targeted proteomic studies for the first time, as demonstrated on 770 tryptic yeast peptides analyzed in one 60-min experiment. The increased quality of quadrupole-orbitrap data has the potential to improve existing protein quantification methods in complex samples and address the pressing demand of systems biology or biomarker evaluation studies. PMID:22962056

Inductively coupled plasma mass spectrometer with axial field in a quadrupole reaction cell.

PubMed

Bandura, Dmitry R; Baranov, Vladimir I; Tanner, Scott D

2002-10-01

A novel reaction cell for ICP-MS with an electric field provided inside the quadrupole along its axis is described. The field is implemented via a DC bias applied to additional auxiliary electrodes inserted between the rods of the quadrupole. The field reduces the settling time of the pressurized quadrupole when its mass bandpass is dynamically tuned. It also improves the transmission of analyte ions. It is shown that for the pressurized cell with the field activated, the recovery time for a change in quadrupole operating parameters is reduced to <4 ms, which allows fast tuning of the mass bandpass in concert with and at the speed of the analyzing quadrupole. When the cell is operated with ammonia, the field reduces ion-ammonia cluster formation, further enhancing the transmission of atomic ions that have a high cluster formation rate. Ni x (NH3)n+ cluster formation in a cell operated with a wide bandpass (i.e., Ni+ precursors are stable in the cell) is shown to be dependent on the axial field strength. Clusters at n = 2-4 can be suppressed by 9, 1200, and >610 times, respectively. The use of a retarding axial field for in-situ energy discrimination against cluster and polyatomic ions is shown. When the cell is pressurized with O2 for suppression of 129Xe+, the formation of 127IH2+ by reactions with gas impurities limits the detection of 129I to isotopic abundance of approximately 10(-6). In-cell energy discrimination against 127IH2+ utilizing a retarding axial field is shown to reduce the abundance of the background at m/z = 129 to ca. 3 x 10(-8) of the 127I+ signal. In-cell energy discrimination against 127IH2+ is shown to cause less I+ loss than a post-cell potential energy barrier for the same degree of 127IH2+ suppression.

Role of the Excitability Brake Potassium Current IKD in Cold Allodynia Induced by Chronic Peripheral Nerve Injury.

PubMed

González, Alejandro; Ugarte, Gonzalo; Restrepo, Carlos; Herrera, Gaspar; Piña, Ricardo; Gómez-Sánchez, José Antonio; Pertusa, María; Orio, Patricio; Madrid, Rodolfo

2017-03-22

Cold allodynia is a common symptom of neuropathic and inflammatory pain following peripheral nerve injury. The mechanisms underlying this disabling sensory alteration are not entirely understood. In primary somatosensory neurons, cold sensitivity is mainly determined by a functional counterbalance between cold-activated TRPM8 channels and Shaker-like Kv1.1-1.2 channels underlying the excitability brake current I KD Here we studied the role of I KD in damage-triggered painful hypersensitivity to innocuous cold. We found that cold allodynia induced by chronic constriction injury (CCI) of the sciatic nerve in mice, was related to both an increase in the proportion of cold-sensitive neurons (CSNs) in DRGs contributing to the sciatic nerve, and a decrease in their cold temperature threshold. I KD density was reduced in high-threshold CSNs from CCI mice compared with sham animals, with no differences in cold-induced TRPM8-dependent current density. The electrophysiological properties and neurochemical profile of CSNs revealed an increase of nociceptive-like phenotype among neurons from CCI animals compared with sham mice. These results were validated using a mathematical model of CSNs, including I KD and TRPM8, showing that a reduction in I KD current density shifts the thermal threshold to higher temperatures and that the reduction of this current induces cold sensitivity in former cold-insensitive neurons expressing low levels of TRPM8-like current. Together, our results suggest that cold allodynia is largely due to a functional downregulation of I KD in both high-threshold CSNs and in a subpopulation of polymodal nociceptors expressing TRPM8, providing a general molecular and neural mechanism for this sensory alteration. SIGNIFICANCE STATEMENT This paper unveils the critical role of the brake potassium current I KD in damage-triggered cold allodynia. Using a well-known form of nerve injury and combining behavioral analysis, calcium imaging, patch clamping, and pharmacological tools, validated by mathematical modeling, we determined that the functional expression of I KD is reduced in sensory neurons in response to peripheral nerve damage. This downregulation not only enhances cold sensitivity of high-threshold cold thermoreceptors signaling cold discomfort, but it also transforms a subpopulation of polymodal nociceptors signaling pain into neurons activated by mild temperature drops. Our results suggest that cold allodynia is linked to a reduction of I KD in both high-threshold cold thermoreceptors and nociceptors expressing TRPM8, providing a general model for this form of cold-induced pain. Copyright © 2017 the authors 0270-6474/17/373109-18$15.00/0.

Identification of Differentially Expressed Genes in Chilling-Induced Potato (Solanum tuberosum L.); a Data Analysis Study.

PubMed

Koc, I; Vatansever, R; Ozyigit, I I; Filiz, E

2015-10-01

Cold stress, as chilling (<20 °C) or freezing (<0 °C), is one of the frequently exposed stresses in cultivated plants like potato. Under cold stress, plants differentially modulate their gene expression to develop a cold tolerance/acclimation. In the present study, we aimed to identify the overall gene expression profile of chilling-stressed (+4 °C) potato at four time points (4, 8, 12, and 48 h), with a particular emphasis on the genes related with transcription factors (TFs), phytohormones, lipid metabolism, signaling pathway, and photosynthesis. A total of 3504 differentially expressed genes (DEGs) were identified at four time points of chilling-induced potato, of which 1397 were found to be up-regulated while 2107 were down-regulated. Heatmap showed that genes were mainly up-regulated at 4-, 8-, and 12-h time points; however, at 48-h time point, they inclined to down-regulate. Seventy five up-regulated TF genes were identified from 37 different families/groups, including mainly from bHLH, WRKY, CCAAT-binding, HAP3, and bZIP families. Protein kinases and calcium were major signaling molecules in cold-induced signaling pathway. A collaborated regulation of phytohormones was observed in chilling-stressed potato. Lipid metabolisms were regulated in a way, highly probably, to change membrane composition to avoid cold damage and render in signaling. A down-regulated gene expression profile was observed in photosynthesis pathway, probably resulting from chilling-induced reduced enzyme activity or light-triggered ROSs damage. The findings of this study will be a valuable theoretical knowledge in terms of understanding the chilling-induced tolerance mechanisms in cultivated potato plants as well as in other Solanum species.

[Chinese classical formulas Ephedra associated prescriptions for treatment of skin diseases].

PubMed

Fan, Yi-Ping; Xiong, Xing-Jiang

2018-06-01

Chinese classical formulas, firstly recorded in Shanghan Zabing Lun by Zhang Zhongjing in the Han dynasty, have been widely used by traditional Chinese medicine physicians for thousands of years due to its good compatibility, strict structures, significant clinical efficacy and less adverse effects. Ephedra associated prescriptions, widely used in the treatment of skin diseases, are famous representative prescriptions in Chinese classical formulas. The commonly used Ephedra associated prescriptions include Mahuang Lianqiao Chixiaodou decoction, Maxing Shigan decoction, Maxing Yigan decoction, Mahuang decoction, Mahuang Jiazhu decoction, Guizhi Mahuang Geban decoction, and Guizhi Eryue Biyi decoction. Skin allergy is an allergic reaction, manifested as erythema, papules, and itching. It has been identified that Guizhi Mahuang Geban decoction (1/2 Guizhi decoction + 1/2 Mahuang decoction) is effective in dispersing wind and cold, relieving exterior syndrome and dredging the collaterals, so it can be used to treat skin allergy caused by pathogenic wind-cold. Guizhi Eryue Biyi decoction (1/4 Guizhi decoction + 1/8 Yuebi decoction) is effective in dispersing wind and cold, relieving exterior syndrome and clearing heat, so it is mainly used for the syndrome of wind-cold tightening superficies and heat transformed from wind-cold. Additionally, Mahuang Lianqiao Chixiaodou decoction can relieve exterior syndrome, clear heat and remove dampness, mainly for the dampness and heat depression in the muscle surface. It is found that Guizhi Mahuang Geban decoction and Guizhi Eryue Biyi decoction have certain efficacy for skin allergies, while Mahuang Lianqiao Chixiaodou decoction has significant efficacy for urticaria, acute and chronic eczema, etc. It has been identified that if the conditions of Ephedra associated prescriptions are well mastered by traditional Chinese medicine physicians, they could be widely applied to treat exogenous diseases and miscellaneous diseases. Copyright© by the Chinese Pharmaceutical Association.

The Next Generation of Cold Immersion Dry Suit Design Evolution for Hypothermia Prevention

NASA Technical Reports Server (NTRS)

Galofaro, Joel

2013-01-01

This new utility patent is an active design that relies on the lung's role as an organic heat exchanger for providing deep body core heating of air. It is based on the fact that the greatest heat loss mechanism for an insulated human body immersed in a cold water environment is due to heat loss through respiration. This innovation successfully merges two existing technologies (cold immersion suit and existing valve technologies) to produce a new product that helps prevent against the onset of hypothermia at sea. During normal operations, a human maintains an approximate body temperature of [98.6 F (37 C)]. A mechanism was developed to recover the warm temperature from the body and reticulate it in a survival suit. The primary intention is to develop an encompassing systems design that can both easily and cost effectively be integrated in all existing currently manufactured cold water survival suits, and as such, it should be noted that the cold water immersion suit is only used as a framework or tool for laying out the required design elements. At the heart of the suit is the Warm Air Recovery (WAR) system, which relies on a single, large Main Purge Valve (MPV) and secondary Purge Valves (PV) to operate. The main purge valve has a thin membrane, which is normally closed, and acts as a one-way check valve. When warm air is expelled from the lungs, it causes the main purge valve to open. Air forced from the MPV is dumped directly into the suit, thereby providing warmth to the torso, legs, and arms. A slight positive over-pressure in the suit causes warm waste air (or water if the suit is punctured) to be safely vented into the sea through large PVs located at the bottom of each arm and leg. The secondary purge valves act to prevent the buildup of large concentrations of CO2 gas and help guard against asphyxia. It is noted that the MPV causes the inhalation and exhalation cycles to be completely isolated from one another in the current suit design.

Results from the GSFC fluxgate magnetometer on Pioneer 11

NASA Technical Reports Server (NTRS)

Acuna, M. H.; Ness, N. F.

1976-01-01

A high-field triaxial fluxgate magnetometer was mounted on Pioneer 11 to measure the main magnetic field of Jupiter. It is found that this planetary magnetic field is more complex than that indicated by the results of the Pioneer 10 vector helium magnetometer. At distances less than 3 Jupiter radii, the magnetic field is observed to increase more rapidly than an inverse-cubed distance law associated with any simple dipole model. Contributions from higher-order multipoles are significant, with the quadrupole and octupole being 24 and 21 percent of the dipole moment, respectively. Implications of the results for the study of trapped particles, planetary radio emission, and planetary interiors are discussed. Major conclusions are that the deviation of the main planetary magnetic field from a simple dipole leads to distortion of the L shells of the charged particles and to warping of the magnetic equator. Enhanced absorption effects associated with Amalthea and Io are predicted.

Characterization of ANFO explosive by high accuracy ESI(±)-FTMS with forensic identification on real samples by EASI(-)-MS.

PubMed

Hernandes, Vinicius Veri; Franco, Marcos Fernado; Santos, Jandyson Machado; Melendez-Perez, Jose J; de Morais, Damila Rodrigues; Rocha, Werickson Fortunato de Carvalho; Borges, Rodrigo; de Souza, Wanderley; Zacca, Jorge Jardim; Logrado, Lucio Paulo Lima; Eberlin, Marcos Nogueira; Correa, Deleon Nascimento

2015-04-01

Ammonium nitrate fuel oil (ANFO) is an explosive used in many civil applications. In Brazil, ANFO has unfortunately also been used in criminal attacks, mainly in automated teller machine (ATM) explosions. In this paper, we describe a detailed characterization of the ANFO composition and its two main constituents (diesel and a nitrate explosive) using high resolution and accuracy mass spectrometry performed on an FT-ICR-mass spectrometer with electrospray ionization (ESI(±)-FTMS) in both the positive and negative ion modes. Via ESI(-)-MS, an ion marker for ANFO was characterized. Using a direct and simple ambient desorption/ionization technique, i.e., easy ambient sonic-spray ionization mass spectrometry (EASI-MS), in a simpler, lower accuracy but robust single quadrupole mass spectrometer, the ANFO ion marker was directly detected from the surface of banknotes collected from ATM explosion theft. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Microsolvation of the 5-hydroxyindole cation (5HI+) with nonpolar and quadrupolar ligands: Infrared photodissociation spectra of 5HI+-Ln clusters with L = Ar and N2 (n ≤ 3)

NASA Astrophysics Data System (ADS)

Klyne, Johanna; Dopfer, Otto

2017-07-01

Solvation of biomolecules and their building blocks has a strong influence on their structure and function. Herein we characterize the initial microsolvation of the 5-hydroxyindole cation (5HI+) in its 2A″ ground electronic state with nonpolar and quadrupolar ligands (L = Ar, N2) by infrared photodissociation (IRPD) spectroscopy of cold and mass-selected 5HI+-Ln (n ≤ 3) clusters in a molecular beam and dispersion-corrected density functional theory calculations (B3LYP-D3/aug-cc-pVTZ). The isomer-selective OH and NH stretch frequency shifts (ΔνOH/NH) disentangle the competition between H-bonding to the acidic OH and NH groups and π-stacking to the conjugated bicyclic aromatic π-electron system, the intermolecular interaction strengths, and the cluster growth sequence. For 5HI+-Arn, H-bonding and π-stacking strongly compete, indicating that dispersion forces are important for the interaction of 5HI+ with nonpolar ligands. In contrast, for 5HI+-(N2)n clusters, the H-bonds are much stronger than the π-bonds and largely determine the initial solvation process. In all clusters, the OH…L bonds are stronger than the NH…L bonds followed by the π-bonds. The interaction of 5HI+ with N2 is roughly twice stronger than with Ar, mainly due to the additional quadrupole moment of N2. The nature and strength of the individual interactions are quantified by the noncovalent interaction approach. Comparison of 5HI+-L with the corresponding neutral clusters reveals the strong impact of ionization on the total and relative interaction strengths of the H-bonds and π-bonds. In addition, comparison of 5HI+-L with corresponding clusters of the phenol, indole, and pyrrole radical cations illustrates the effects of substitution of functional groups and the addition of aromatic rings to the various subunits of 5HI on the intermolecular potential.

The Effects of Exhaustive Exercise on Thermoregulatory Fatigue During Cold Exposure

DTIC Science & Technology

2002-04-01

exercise routine for days 1-7 consisted of the following activities each day: running & sprinting (hiking substituted on D3 & D7), weightlifting ...ergometry, and an anaerobic power test. Subjects ran 4.8 km at their personal best and sprinted 800 m three consecutive times. Weightlifting consisted of one... injury on Day 5 and did not participate in the Day 7 cold exposure. The main reasons for not completing all 6 hours during CW included hip flexor

Investigation of non-stationary self-focusing of intense laser pulse in cold quantum plasma using ramp density profile

DOE Office of Scientific and Technical Information (OSTI.GOV)

Habibi, M.; Ghamari, F.

2012-11-15

The authors have investigated the non-stationary self-focusing of Gaussian laser pulse in cold quantum plasma. In case of high dense plasma, the nonlinearity in the dielectric constant is mainly due to relativistic high intense interactions and quantum effects. In this paper, we have introduced a ramp density profile for plasma and presented graphically the behavior of spot size oscillations of pulse at rear and front portions of the pulse. It is observed that the ramp density profile and quantum effects play a vital role in stronger and better focusing at the rear of the pulse than at the front inmore » cold quantum plasmas.« less

Profiling the indole alkaloids in yohimbe bark with ultra-performance liquid chromatography coupled with ion mobility quadrupole time-of-flight mass spectrometry

USDA-ARS?s Scientific Manuscript database

An ultra-high performance liquid chromatography-ion mobility- quadrupole time-of-flight mass spectrometry (UHPLC-IM-QTOF-MS) method was developed for profiling the indole alkaloids in yohimbe bark. Many indole alkaloids with the yohimbine core structure, plus methylated, oxidized, and reduced speci...

Metabolic profiling of Hoodia, Chamomile, Terminalia Species and evaluation of commercial preparations using Ultra-High Performance Quadrupole Time of Flight-Mass Spectrometry

USDA-ARS?s Scientific Manuscript database

Ultra-High Performance-Quadrupole Time of Flight Mass Spectrometr(UHPLC-QToF-MS)profiling has become an impattant tool for identification of marker compounds and generation of metabolic patterns that could be interrogated using chemometric modeling software. Chemometric approaches can be used to ana...

Variable Permanent Magnet Quadrupole

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mihara, T.; Iwashita, Y.; /Kyoto U.

A permanent magnet quadrupole (PMQ) is one of the candidates for the final focus lens in a linear collider. An over 120 T/m strong variable permanent magnet quadrupole is achieved by the introduction of saturated iron and a 'double ring structure'. A fabricated PMQ achieved 24 T integrated gradient with 20 mm bore diameter, 100 mm magnet diameter and 20 cm pole length. The strength of the PMQ is adjustable in 1.4 T steps, due to its 'double ring structure': the PMQ is split into two nested rings; the outer ring is sliced along the beam line into four partsmore » and is rotated to change the strength. This paper describes the variable PMQ from fabrication to recent adjustments.« less

Modeling of Dipole and Quadrupole Fringe-Field Effects for the Advanced Photon Source Upgrade Lattice

DOE Office of Scientific and Technical Information (OSTI.GOV)

Borland, M.; Lindberg, R.

2017-06-01

The proposed upgrade of the Advanced Photon Source (APS) to a multibend-achromat lattice requires shorter and much stronger quadrupole magnets than are present in the existing ring. This results in longitudinal gradient profiles that differ significantly from a hard-edge model. Additionally, the lattice assumes the use of five-segment longitudinal gradient dipoles. Under these circumstances, the effects of fringe fields and detailed field distributions are of interest. We evaluated the effect of soft-edge fringe fields on the linear optics and chromaticity, finding that compensation for these effects is readily accomplished. In addition, we evaluated the reliability of standard methods of simulatingmore » hardedge nonlinear fringe effects in quadrupoles.« less

Fermilab Booster Transition Crossing Simulations and Beam Studies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bhat, C. M.; Tan, C. Y.

2016-01-01

The Fermilab Booster accelerates beam from 400 MeV to 8 GeV at 15 Hz. In the PIP (Proton Improvement Plan) era, it is required that Booster deliver 4.2 xmore » $$10^{12}$$ protons per pulse to extraction. One of the obstacles for providing quality beam to the users is the longitudinal quadrupole oscillation that the beam suffers from right after transition. Although this oscillation is well taken care of with quadrupole dampers, it is important to understand the source of these oscillations in light of the PIP II requirements that require 6.5 x $$10^{12}$$ protons per pulse at extraction. This paper explores the results from machine studies, computer simulations and solutions to prevent the quadrupole oscillations after transition.« less

Electrostatic attraction between neutral microdroplets by ion fluctuations

NASA Astrophysics Data System (ADS)

Sheng, Yu-Jane; Tsao, Heng-Kwong

2004-06-01

The interaction between two aqueous droplets containing ions is investigated. The ion-fluctuation correlation gives rise to attraction between two neutral microdroplets, similar to the van der Waals interaction between neutral atoms. Electrostatic attraction consists of contributions from various induced multipole-multipole interactions, including dipole-dipole < P2z >2 r-6 , dipole-quadrupole < P2z > < Q 2zz > r-8 , dipole-octupole < P2z > < O 2zzz > r-10 , and quadrupole-quadrupole interactions < Q 2zz >2 r-10 . The mean-square multipole moments are determined analytically by linear response theory. The fluctuation-driven attraction is so strong at short distance that it may dominate over the Coulomb repulsion between like-charged droplets. These theoretical results are confirmed by Monte Carlo simulations.

Electrostatic attraction between neutral microdroplets by ion fluctuations.

PubMed

Sheng, Yu-Jane; Tsao, Heng-Kwong

2004-06-01

The interaction between two aqueous droplets containing ions is investigated. The ion-fluctuation correlation gives rise to attraction between two neutral microdroplets, similar to the van der Waals interaction between neutral atoms. Electrostatic attraction consists of contributions from various induced multipole-multipole interactions, including dipole-dipole < P(2)(z) >(2) r(-6), dipole-quadrupole < P(2)(z) > < Q (2)(zz ) > r(-8), dipole-octupole < P(2)(z) > < O (2)(zzz ) > r(-10), and quadrupole-quadrupole interactions < Q (2)(zz ) >(2) r(-10). The mean-square multipole moments are determined analytically by linear response theory. The fluctuation-driven attraction is so strong at short distance that it may dominate over the Coulomb repulsion between like-charged droplets. These theoretical results are confirmed by Monte Carlo simulations.

RFQ device for accelerating particles

DOEpatents

Shepard, K.W.; Delayen, J.R.

1995-06-06

A superconducting radio frequency quadrupole (RFQ) device includes four spaced elongated, linear, tubular rods disposed parallel to a charged particle beam axis, with each rod supported by two spaced tubular posts oriented radially with respect to the beam axis. The rod and post geometry of the device has four-fold rotation symmetry, lowers the frequency of the quadrupole mode below that of the dipole mode, and provides large dipole-quadrupole mode isolation to accommodate a range of mechanical tolerances. The simplicity of the geometry of the structure, which can be formed by joining eight simple T-sections, provides a high degree of mechanical stability, is insensitive to mechanical displacement, and is particularly adapted for fabrication with superconducting materials such as niobium. 5 figs.

Magnetic fringe field interference between the quadrupole and corrector magnets in the CSNS/RCS

NASA Astrophysics Data System (ADS)

Yang, Mei; Kang, Wen; Deng, Changdong; Sun, Xianjing; Li, Li; Wu, Xi; Gong, Lingling; Cheng, Da; Zhu, Yingshun; Chen, Fusan

2017-03-01

The Rapid Cycling Synchrotron (RCS) of the China Spallation Neutron Source (CSNS) employs large aperture quadrupole and corrector magnets with small aspect ratios and relatively short iron to iron separations; so the fringe field interference becomes serious which results in integral field strength reduction and extra field harmonics. We have performed 3D magnetic field simulations to investigate the magnetic field interference in the magnet assemblies and made some adjustments on the magnet arrangement. The Fourier analysis is used to quantify the integral gradient reduction and field harmonic changes of the quadrupole magnets. Some magnetic field measurements are undertaken to verify the simulation results. The simulation details and the major results are presented in this paper.

Ion-mobility study of two functionalized pentacene structural isomers using a modified electrospray/triple quadrupole mass spectrometer

NASA Astrophysics Data System (ADS)

Prada, Svitlana V.; Bohme, Diethard K.; Baranov, Vladimir I.

2007-03-01

We report ion-mobility measurements with a modified triple quadrupole mass spectrometer fitted with an ion molecule reactor (IMR) designed to investigate ion molecule reactivity in organic mass spectrometry. Functionalized pentacene ions, which are generally unreactive were chosen for study to decouple drift/diffusion effects from reactivity (including clustering). The IMR is equipped with a variable axial electrostatic drift field (ADF) and is able to trap ions. These capabilities were successfully employed in the measurement of ion mobilities in different modes of IMR operation. Theoretical modeling of the drift dynamics and the special localization of the large ion packet was successfully implemented. The contribution of the quadrupole RF field to the drift dynamics also was taken into consideration.

Expression Patterns of Three Genes Under Short and Long Term Cold Exposure in Thitarodes pui (Lepidoptera: Hepialidae), A Host of Ophiocordyceps sinensis.

PubMed

Min, Q; Cheng, S Y; Xi, J F; Ma, J; Xin, T R; Xia, B; Zou, Z W

　　BACKGROUND: Thitarodes larvae are the host of the caterpillar fungus Ophiocordyceps sinensis. Low temperature is the main environmental limitation for larvae growth. To better understand the cold adaption process in T. pui larvae, the expression patterns of trehalose-6-phosphate synthase (TpTPS), heat shock protein 70 (TpHSP70), and heat shock protein 90 (TpHSP90) were investigated upon short and long-term exposure to 0°C. The 6th instar T. pui larvae were collected in July 2013. TpTPS was firstly sequenced and expression patterns of TpTPS, TpHSP70 and TpHSP90 were investigated using quantitative PCR. Full-length cDNA of TpTPS was 3,012 bp, with an open reading frame of 2,472 bp and an encoding protein of 823 amino acids. TpTPS up-regulation was induced by cold exposure. TpHSP70 expression is altered by cold exposure, but remained low. TpHSP90 expression was obviously up regulated in long-term cold stimulation. All three genes (TpTPS, TpHSP70 and TpHSP90) have likely contributed to cold tolerance in T. pui larvae, TpTPS and TpHSP90 potentially being more important.

Thermo-mechanical Design Methodology for ITER Cryodistribution cold boxes

NASA Astrophysics Data System (ADS)

Shukla, Vinit; Patel, Pratik; Das, Jotirmoy; Vaghela, Hitensinh; Bhattacharya, Ritendra; Shah, Nitin; Choukekar, Ketan; Chang, Hyun-Sik; Sarkar, Biswanath

2017-04-01

The ITER cryo-distribution (CD) system is in charge of proper distribution of the cryogen at required mass flow rate, pressure and temperature level to the users; namely the superconducting (SC) magnets and cryopumps (CPs). The CD system is also capable to use the magnet structures as a thermal buffer in order to operate the cryo-plant as much as possible at a steady state condition. A typical CD cold box is equipped with mainly liquid helium (LHe) bath, heat exchangers (HX’s), cryogenic valves, filter, heaters, cold circulator, cold compressor and process piping. The various load combinations which are likely to occur during the life cycle of the CD cold boxes are imposed on the representative model and impacts on the system are analyzed. This study shows that break of insulation vacuum during nominal operation (NO) along with seismic event (Seismic Level-2) is the most stringent load combination having maximum stress of 224 MPa. However, NO+SMHV (Séismes Maximaux Historiquement Vraisemblables = Maximum Historically Probable Earthquakes) load combination is having the least safety margin and will lead the basis of the design of the CD system and its sub components. This paper presents and compares the results of different load combinations which are likely to occur on a typical CD cold box.

The Radio Spectra and - Inertial Defects Behavior of Planar Aromatic Heterocycles

NASA Astrophysics Data System (ADS)

McNaughton, Don; Jahn, Michaela K.; Grabow, Jens-Uwe; Godfrey, Peter; Travers, Michael; Wachsmuth, Dennis

2016-06-01

The simplest tricyclic aromatic nitrogen heterocyclic molecules 5,6 benzoquinoline and 7,8 benzoquinoline are possible candidates for detection of aromatic systems in the interstellar medium. Therefore the pure rotational spectra have been recorded using frequency-scanned Stark modulated, jet-cooled millimetre wave absorption spectroscopy (48-87 GHz) and Fourier Transform Microwave (FT MW) spectroscopy (2-26 GHz) of a supersonic rotationally cold molecular jet. Guided by ab initio molecular orbital predictions, spectral analysis of mm wave spectra, and higher resolution FT MW spectroscopy provided accurate rotational and centrifugal distortion constants together with 14N nuclear quadrupole coupling constants for both species. The determined inertial defects, along with those of similar species are used to develop an empirical formula for calculation of inertial defects of aromatic ring systems. The predictive ability of the formula is shown to be excellent for planar species with a number of pronounced out of plane vibrations. The resultant constants are of sufficient accuracy to be used in potential astrophysical searches. We gratefully acknowledge support from the Deutsche Forschungsgemeinschaft, the Deutsche Akademische Austauschdienst, as well as the Land Niedersachsen (J.-U.G). DMcN also thanks the Royal Society of Chemistry for their generous travel support.

FK506-Binding Protein 22 from a Psychrophilic Bacterium, a Cold Shock-Inducible Peptidyl Prolyl Isomerase with the Ability to Assist in Protein Folding

PubMed Central

Budiman, Cahyo; Koga, Yuichi; Takano, Kazufumi; Kanaya, Shigenori

2011-01-01

Adaptation of microorganisms to low temperatures remains to be fully elucidated. It has been previously reported that peptidyl prolyl cis-trans isomerases (PPIases) are involved in cold adaptation of various microorganisms whether they are hyperthermophiles, mesophiles or phsycrophiles. The rate of cis-trans isomerization at low temperatures is much slower than that at higher temperatures and may cause problems in protein folding. However, the mechanisms by which PPIases are involved in cold adaptation remain unclear. Here we used FK506-binding protein 22, a cold shock protein from the psychrophilic bacterium Shewanella sp. SIB1 (SIB1 FKBP22) as a model protein to decipher the involvement of PPIases in cold adaptation. SIB1 FKBP22 is homodimer that assumes a V-shaped structure based on a tertiary model. Each monomer consists of an N-domain responsible for dimerization and a C-catalytic domain. SIB1 FKBP22 is a typical cold-adapted enzyme as indicated by the increase of catalytic efficiency at low temperatures, the downward shift in optimal temperature of activity and the reduction in the conformational stability. SIB1 FKBP22 is considered as foldase and chaperone based on its ability to catalyze refolding of a cis-proline containing protein and bind to a folding intermediate protein, respectively. The foldase and chaperone activites of SIB1 FKBP22 are thought to be important for cold adaptation of Shewanella sp. SIB1. These activities are also employed by other PPIases for being involved in cold adaptation of various microorganisms. Despite other biological roles of PPIases, we proposed that foldase and chaperone activities of PPIases are the main requirement for overcoming the cold-stress problem in microorganisms due to folding of proteins. PMID:21954357

Intermittent whole-body cold immersion induces similar thermal stress but different motor and cognitive responses between males and females.

PubMed

Solianik, Rima; Skurvydas, Albertas; Mickevičienė, Dalia; Brazaitis, Marius

2014-10-01

The main aim of this study was to compare the thermal responses and the responses of cognitive and motor functions to intermittent cold stress between males and females. The intermittent cold stress continued until rectal temperature (TRE) reached 35.5°C or for a maximum of 170 min. Thermal response and motor and cognitive performance were monitored. During intermittent cold stress, body temperature variables decreased in all subjects (P < 0.001) and did not differ between sexes. The presence of fast and slow cooling types for participants with similar effect on physiological variables were observed; thus the different rate coolers were grouped together and were attributed only sex specific responses. Overall, TRE cooling rate and cold strain index did not differ between sexes. Maximal voluntary contraction (MVC) decreased after intermittent cold exposure only in males (P < 0.001), whereas changes in muscle electromyography (EMG) activity did not differ between sexes. The effects of intermittent cold stress on electrically evoked muscle properties, spinal (H-reflex), and supraspinal (V-waves) reflexes did not differ between sexes. Intermittent cold-induced cognitive perturbation of attention and memory task performance was greater in males (P < 0.05). Contrary to our expectations, the results of the present study indicated that males and females experience similar thermal stress induced by intermittent whole-body cold immersion. Although no sex-specific differences were observed in muscle EMG activity, involuntary muscle properties, spinal and supraspinal reflexes, some of the sex differences observed (e.g., lower isometric MVC and greater cognitive perturbation in males) support the view of sex-specific physiological responses to core temperature decrease. Copyright © 2014 Elsevier Inc. All rights reserved.

THE CANADA-FRANCE ECLIPTIC PLANE SURVEY-L3 DATA RELEASE: THE ORBITAL STRUCTURE OF THE KUIPER BELT

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kavelaars, J. J.; Jones, R. L.; Murray, I.

2009-06-15

We report the orbital distribution of the trans-Neptunian comets discovered during the first discovery year of the Canada-France Ecliptic Plane Survey (CFEPS). CFEPS is a Kuiper Belt object survey based on observations acquired by the Very Wide component of the Canada-France-Hawaii Telescope Legacy Survey (LS-VW). The first year's detections consist of 73 Kuiper Belt objects, 55 of which have now been tracked for three years or more, providing precise orbits. Although this sample size is small compared to the world-wide inventory, because we have an absolutely calibrated and extremely well-characterized survey (with known pointing history) we are able to de-biasmore » our observed population and make unbiased statements about the intrinsic orbital distribution of the Kuiper Belt. By applying the (publically available) CFEPS Survey Simulator to models of the true orbital distribution and comparing the resulting simulated detections to the actual detections made by the survey, we are able to rule out several hypothesized Kuiper Belt object orbit distributions. We find that the main classical belt's so-called 'cold' component is confined in semimajor axis (a) and eccentricity (e) compared to the more extended 'hot' component; the cold component is confined to lower e and does not stretch all the way out to the 2:1 resonance but rather depletes quickly beyond a = 45 AU. For the cold main classical belt population we find a robust population estimate of N(H{sub g} < 10) = 50 {+-} 5 x 10{sup 3} and find that the hot component of the main classical belt represents {approx}60% of the total population. The inner classical belt (sunward of the 3:2 mean-motion resonance) has a population of roughly 2000 trans-Neptunian objects with absolute magnitudes H{sub g} < 10, and may not share the inclination distribution of the main classical belt. We also find that the plutino population lacks a cold low-inclination component, and so, the population is somewhat larger than recent estimates; our analysis shows a plutino population of N(H{sub g} < 10){approx} 25{sup +25} {sub -12} x 10{sup 3}compared to our estimate of the size of main classical Kuiper Belt population of N(H{sub g} < 10) {approx} (126{sup +50} {sub -46}) x 10{sup 3}.« less

Mortality related to extreme temperature for 15 cities in northeast Asia.

PubMed

Chung, Yeonseung; Lim, Youn-Hee; Honda, Yasushi; Guo, Yue-Liang Leon; Hashizume, Masahiro; Bell, Michelle L; Chen, Bing-Yu; Kim, Ho

2015-03-01

Multisite time-series studies for temperature-related mortality have been conducted mainly in the United States and Europe, but are lacking in Asia. This multisite time-series study examined mortality related to extreme temperatures (both cold and hot) in Northeast Asia, focusing on 15 cities of 3 high-income countries. This study includes 3 cities in Taiwan for 1994-2007, 6 cities in Korea for 1992-2010, and 6 cities in Japan for 1972-2009. We used 2-stage Bayesian hierarchical Poisson semiparametric regression to model the nonlinear relationship between temperature and mortality, providing city-specific and country-wide estimates for cold and heat effects. Various exposure time frames, age groups, and causes of death were considered. Cold effects had longer time lags (5-11 days) than heat effects, which were immediate (1-3 days). Cold effects were larger for cities in Taiwan, whereas heat effects were larger for cities in Korea and Japan. Patterns of increasing effects with age were observed in both cold and heat effects. Both cold and heat effects were larger for cardiorespiratory mortality than for other causes of death. Several city characteristics related to weather or air pollution were associated with both cold and heat effects. Mortality increased with either cold or hot temperature in urban populations of high-income countries in Northeast Asia, with spatial variations of effects among cities and countries. Findings suggest that climate factors are major contributors to the spatial heterogeneity of effects in this region, although further research is merited to identify other factors as determinants of variability.

Quantitative Trait Loci for Cold Tolerance of Rice Recombinant Inbred Lines in Low Temperature Environments

PubMed Central

Jiang, Wenzhu; Jin, Yong-Mei; Lee, Joohyun; Lee, Kang-Ie; Piao, Rihua; Han, Longzhi; Shin, Jin-Chul; Jin, Rong-De; Cao, Tiehua; Pan, Hong-Yu; Du, Xinglin; Koh, Hee-Jong

2011-01-01

Low temperature is one of the major environmental stresses in rice cultivation in high-altitude and high-latitude regions. In this study, we cultivated a set of recombinant inbred lines (RIL) derived from Dasanbyeo (indica) / TR22183 (japonica) crosses in Yanji (high-latitude area), Kunming (high-altitude area), Chuncheon (cold water irrigation) and Suwon (normal) to evaluate the main effects of quantitative trait loci (QTL) and epistatic QTL (E-QTL) with regard to their interactions with environments for coldrelated traits. Six QTLs for spikelet fertility (SF) were identified in three cold treatment locations. Among them, four QTLs on chromosomes 2, 7, 8, and 10 were validated by several near isogenic lines (NILs) under cold treatment in Chuncheon. A total of 57 QTLs and 76 E-QTLs for nine cold-related traits were identified as distributing on all 12 chromosomes; among them, 19 QTLs and E-QTLs showed significant interactions of QTLs and environments (QEIs). The total phenotypic variation explained by each trait ranged from 13.2 to 29.1% in QTLs, 10.6 to 29.0% in EQTLs, 2.2 to 8.8% in QEIs and 1.0% to 7.7% in E-QTL × environment interactions (E-QEIs). These results demonstrate that epistatic effects and QEIs are important properties of QTL parameters for cold tolerance at the reproductive stage. In order to develop cold tolerant varieties adaptable to wide-ranges of cold stress, a strategy facilitating marker-assisted selection (MAS) is being adopted to accumulate QTLs identified from different environments. PMID:22080374

Comparison of characteristics of aerosol during rainy weather and cold air-dust weather in Guangzhou in late March 2012

NASA Astrophysics Data System (ADS)

Chen, Huizhong; Wu, Dui; Yu, Jianzhen

2016-04-01

Using the data on aerosol observed hourly by Marga ADI 2080 and Grimm 180, we compared the characteristics of aerosol during rainy weather and cold air-dust weather in Guangzhou in late March 2012. The mass concentration of aerosol appeared distinct between the two weather processes. During rainy weather, the mass concentration of PM and total water-soluble components decreased obviously. During cold air-dust weather, the cleaning effect of cold air occurred much more suddenly and about a half day earlier than the dust effect. As a result, the mass concentration of PM and total water-soluble components first dropped dramatically to a below-normal level and then rose gradually to an above-normal level. The ratio of PM2.5/PM10 and PM1/PM10 decreased, suggesting that dust-storm weather mainly brought in coarse particles. The proportion of Ca2+ in the total water-soluble components significantly increased to as high as 50 % because of the effect of dust weather. We further analysed the ionic equilibrium during rainy and cold air-dust weather, and compared it with that during hazy weather during the same period. The aerosol during rainy weather was slightly acidic, whereas that during hazy weather and cold air-dust weather was obviously alkaline, with that during cold air-dust weather being significantly more alkaline. Most of the anions, including SO4 2- and NO3 -, were neutralised by NH4 + during rainy and hazy weather, and by Ca2+ during cold air-dust weather.

Cold air analgesia as pain reduction during photodynamic therapy of actinic keratoses.

PubMed

Stangeland, K Z; Kroon, S

2012-07-01

Photodynamic therapy (PDT) is an effective treatment for actinic keratoses and non-melanoma skin cancer. The main side effect of PDT is pain during the illumination. To assess the effect of cold air as pain relief during MAL-PDT for field cancerization on different body areas. A prospective, open, intra-individual right-left comparison study was performed in 43 patients with MAL-PDT as field cancerization. One area received cold air analgesia while the other did not. Pain was evaluated by numeric rating scale (NRS) during the illumination. The patients' received a questionnaire and recorded pain and postinflammatory symptoms on a visual analogue scale (VAS). We found a statistical significant difference in overall pain score at 3 and 9 minutes. The area receiving cold air during illumination had a mean NRS of 5.1 while the opposite side, not receiving cold air, had NRS of 6.1. At 9 minutes the side receiving cold air had mean NRS of 5.0, and the side without had 5.7. The pain difference on the chest was the most pronounced with a NRS of 5.2 without air and 3.5 with cold air. There was a significant difference in erythema immediately after, 1 h and 24 h after illumination. Small, open, not blinded study. The difference in pain was small. Cold air is an effective method for moderate pain relief. It is an easy, noninvasive method that can be used on all body parts. © 2011 The Authors. Journal of the European Academy of Dermatology and Venereology © 2011 European Academy of Dermatology and Venereology.

Observable signatures of a classical transition

NASA Astrophysics Data System (ADS)

Johnson, Matthew C.; Lin, Wei

2016-03-01

Eternal inflation arising from a potential landscape predicts that our universe is one realization of many possible cosmological histories. One way to access different cosmological histories is via the nucleation of bubble universes from a metastable false vacuum. Another way to sample different cosmological histories is via classical transitions, the creation of pocket universes through the collision between bubbles. Using relativistic numerical simulations, we examine the possibility of observationally determining if our observable universe resulted from a classical transition. We find that classical transitions produce spatially infinite, approximately open Friedman-Robertson-Walker universes. The leading set of observables in the aftermath of a classical transition are negative spatial curvature and a contribution to the Cosmic Microwave Background temperature quadrupole. The level of curvature and magnitude of the quadrupole are dependent on the position of the observer, and we determine the possible range of observables for two classes of single-scalar field models. For the first class, where the inflationary phase has a lower energy than the vacuum preceding the classical transition, the magnitude of the observed quadrupole generally falls to zero with distance from the collision while the spatial curvature grows to a constant. For the second class, where the inflationary phase has a higher energy than the vacuum preceding the classical transition, the magnitude of the observed quadrupole generically falls to zero with distance from the collision while the spatial curvature grows without bound. We find that the magnitude of the quadrupole and curvature grow with increasing centre of mass energy of the collision, and explore variations of the parameters in the scalar field lagrangian.

Observable signatures of a classical transition

DOE Office of Scientific and Technical Information (OSTI.GOV)

Johnson, Matthew C.; Lin, Wei, E-mail: mjohnson@perimeterinstitute.ca, E-mail: lewisweilin@gmail.com

2016-03-01

Eternal inflation arising from a potential landscape predicts that our universe is one realization of many possible cosmological histories. One way to access different cosmological histories is via the nucleation of bubble universes from a metastable false vacuum. Another way to sample different cosmological histories is via classical transitions, the creation of pocket universes through the collision between bubbles. Using relativistic numerical simulations, we examine the possibility of observationally determining if our observable universe resulted from a classical transition. We find that classical transitions produce spatially infinite, approximately open Friedman-Robertson-Walker universes. The leading set of observables in the aftermath ofmore » a classical transition are negative spatial curvature and a contribution to the Cosmic Microwave Background temperature quadrupole. The level of curvature and magnitude of the quadrupole are dependent on the position of the observer, and we determine the possible range of observables for two classes of single-scalar field models. For the first class, where the inflationary phase has a lower energy than the vacuum preceding the classical transition, the magnitude of the observed quadrupole generally falls to zero with distance from the collision while the spatial curvature grows to a constant. For the second class, where the inflationary phase has a higher energy than the vacuum preceding the classical transition, the magnitude of the observed quadrupole generically falls to zero with distance from the collision while the spatial curvature grows without bound. We find that the magnitude of the quadrupole and curvature grow with increasing centre of mass energy of the collision, and explore variations of the parameters in the scalar field lagrangian.« less

Temporal dynamics of direct N2O fluxes from agro-ecosystems in cold climates: importance of year-round measurements in multiple cropping systems

NASA Astrophysics Data System (ADS)

Wagner-Riddle, C.; Tenuta, M.

2014-12-01

Soil N2O fluxes (direct emissions) are highly variable in time and space due to soil, weather and management drivers. In cold climates, freeze/thaw cycles and short growing seasons can enhance soil N2O production contributing to the temporal variability of fluxes. Year-round measurements of N2O fluxes in multiple cropping systems are needed to decrease the uncertainty of annual emission estimates and to devise mitigation practices for emission reduction in cold climates. We have deployed a micrometeorological flux-gradient approach coupled to a tunable diode laser absorption spectroscopy system at two long-term sites in Canada: Elora, Ontario (2000-2014) and Glenlea, Manitoba (2006-2014). Quasi-simultaneous half-hourly flux measurements on four 4-ha fields within a level and aerodynamically homogeneous landscape were obtained allowing for comparison of crop type and/or management practices within and between years. Annual crops such as corn, soybeans, wheat, and barley received typical inorganic fertilizer and/or manure applications, and best management practices such as timing of application and reduced tillage were studied. Perennial grass-alfalfa hayfields were compared to annual crops during selected time periods. Here we synthesize the long-term datasets from these two sites, and quantify the overall contribution of non-growing season (mainly freeze/thaw cycles) and growing season (mainly nitrogen application) to annual emission totals. Uncertainties of regional estimates for cold-climates will be assessed using these long-term datasets.

Permanently densified SiO2 glasses: a structural approach.

PubMed

Martinet, C; Kassir-Bodon, A; Deschamps, T; Cornet, A; Le Floch, S; Martinez, V; Champagnon, B

2015-08-19

Densified silica can be obtained by different pressure and temperature paths and for different stress conditions, hydrostatic or including shear. The density is usually the macroscopic parameter used to characterize the different compressed silica samples. The aim of our present study is to compare structural modifications for silica glass, densified from several routes. For this, densified silica glasses are prepared from cold and high temperature (up to 1020 °C) compressions. The different densified glasses obtained in our study are characterized by micro-Raman spectroscopy. Intertetrahedral angles from the main band relative to the bending mode decrease and their values are larger for densified samples from high temperature compression than those samples from cold compression. The relative amount of 3-membered rings deduced from the D2 line area increases as a function of density for cold compression. The temperature increase during the compression process induces a decrease of the 3 fold ring population. Moreover, 3 fold rings are more deformed and stressed for densified samples at room temperature at the expense of those densified at high temperature. Temperature plays a main role in the reorganization structure during the densification and leads to obtaining a more relaxed structure with lower stresses than glasses densified from cold compression. The role of hydrostatic or non-hydrostatic applied stresses on the glass structure is discussed. From the Sen and Thorpe central force model, intertetrahedral angle average value and their distribution are estimated.

NQRS Data for H4INO3 (Subst. No. 2276)

NASA Astrophysics Data System (ADS)

Chihara, H.; Nakamura, N.

This document is part of Subvolume B 'Substances Containing C10H16 … Zn' of Volume 48 'Nuclear Quadrupole Resonance Spectroscopy Data' of Landolt-Börnstein - Group III 'Condensed Matter'. It contains an extract of Section '3.2 Data tables' of the Chapter '3 Nuclear quadrupole resonance data' providing the NQRS data for H4INO3 (Subst. No. 2276)

NQRS Data for D4INO4 (Subst. No. 2163)

NASA Astrophysics Data System (ADS)

Chihara, H.; Nakamura, N.

This document is part of Subvolume B 'Substances Containing C10H16 … Zn' of Volume 48 'Nuclear Quadrupole Resonance Spectroscopy Data' of Landolt-Börnstein - Group III 'Condensed Matter'. It contains an extract of Section '3.2 Data tables' of the Chapter '3 Nuclear quadrupole resonance data' providing the NQRS data for D4INO4 (Subst. No. 2163)

NQRS Data for H4INO4 (Subst. No. 2277)

NASA Astrophysics Data System (ADS)

Chihara, H.; Nakamura, N.

This document is part of Subvolume B 'Substances Containing C10H16 … Zn' of Volume 48 'Nuclear Quadrupole Resonance Spectroscopy Data' of Landolt-Börnstein - Group III 'Condensed Matter'. It contains an extract of Section '3.2 Data tables' of the Chapter '3 Nuclear quadrupole resonance data' providing the NQRS data for H4INO4 (Subst. No. 2277)

The quadrupole ionosphere

NASA Technical Reports Server (NTRS)

Rishbeth, H.

1986-01-01

The principal features that might exist in the terrestrial paleoionosphere, if the geomagnetic field were to assume a quadrupole form during a polarity reversal are discussed. Complicated phenomena would be expected to occur at magnetic equators and magnetospherically-driven plasma convection might occur at latitudes where the magnetic field is steeply inclined. The influence of magnetic field strength on ionospheric structure is considered in general terms.

Analytical and numerical calculation of the second-order moment of the beam using a capacitive pickup

NASA Astrophysics Data System (ADS)

Tsemo Kamga, Joel Alain; Müller, Wolfgang F. O.; Weiland, Thomas

2016-04-01

Beam emittance has particular importance in particle physics, because it provides information about the quality of the particle beam. There are many techniques for measuring the beam emittance, such as that proposed by Miller et al. [Report No. SLAC-PUB-3186, (A) (1983)]. This technique is based on determining the emittance by measuring the second-order moment of the beam using quadrupole pickups consisting of four symmetrical electrodes placed around the beam pipe at 90° intervals, respectively. Based on Miller's approach, two signal processing methods are generally used to get the quadrupole moment of the beam, namely the difference over sum and the log ratio [P. Li et al., IEEE Nuclear Science Symposium Conference Record, N24-404, 2007, pp. 1675-1678] methods. However, these traditional methods provide results with a good accuracy only for a well centered beam. The method presented in this paper, which starts with Miller's approach, considerably reduces the impact of the dipole signal on the quadrupole moment measurement for both small and large values of the beam position. Furthermore, a methodology for the numerical determination of the sensitivity of quadrupole pickups will be presented.

The Closed Orbit Measurement System at the DELTA Synchrotron Radiation Facility And First Investigations Concerning the Installation of a Beam Based BPM Calibration System

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jankowiak, A.; Wille, K.; /Dortmund U. /SLAC

2011-08-25

For a synchrotron radiation source it is necessary to operate a monitoring system to determine the beam position with high resolution and accuracy with respect to the axis of the quadrupole magnets. In this paper the present closed orbit measurement system of the DELTA SR-Facility, concerning the hardware setup, data processing and the calibration methods, will be presented. The results of the calibration measurements and the recent operating experience will be discussed. These results show, that the system is close to the design resolution. But the BPM offsets with respect to the magnetic center of the quadrupole magnets turn outmore » to be not acceptable. For some BPMs they are in the order of several 100 micro m. Therefore it was decided to install a beam based BPM calibration system in the near future . This system should allow to determine the BPM offsets relative to the center of the quadrupole magnets for all 40 BPMs. It is planned to install a system in order to change the focussing strength of each quadrupole individually either in a static or dynamic way.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Johannsen, Tim; Psaltis, Dimitrios, E-mail: timj@physics.arizona.ed, E-mail: dpsaltis@email.arizona.ed

According to the no-hair theorem, an astrophysical black hole is uniquely described by only two quantities, the mass and the spin. In this series of papers, we investigate a framework for testing the no-hair theorem with observations of black holes in the electromagnetic spectrum. We formulate our approach in terms of a parametric spacetime which contains a quadrupole moment that is independent of both mass and spin. If the no-hair theorem is correct, then any deviation of the black hole quadrupole moment from its Kerr value has to be zero. We analyze in detail the properties of this quasi-Kerr spacetimemore » that are critical to interpreting observations of black holes and demonstrate their dependence on the spin and quadrupole moment. In particular, we show that the location of the innermost stable circular orbit and the gravitational lensing experienced by photons are affected significantly at even modest deviations of the quadrupole moment from the value predicted by the no-hair theorem. We argue that observations of black hole images, of relativistically broadened iron lines, as well as of thermal X-ray spectra from accreting black holes will lead in the near future to an experimental test of the no-hair theorem.« less

Quadrupole Magnetic Sorting of Porcine Islets of Langerhans

PubMed Central

Shenkman, Rustin M.; Chalmers, Jeffrey J.; Hering, Bernhard J.; Kirchhof, Nicole

2009-01-01

Islet transplantation is emerging as a treatment option for selected patients with type 1 diabetes. Inconsistent isolation, purification, and recovery of large numbers of high-quality islets remain substantial impediments to progress in the field. Removing islets as soon as they are liberated from the pancreas during digestion and circumventing the need for density gradient purification is likely to result in substantially increased viable islet yields by minimizing exposure to proteolytic enzymes, reactive oxygen intermediates, and mechanical stress associated with centrifugation. This study capitalized on the hypervascularity of islets compared with acinar tissue to explore their preferential enrichment with magnetic beads to enable immediate separation in a magnetic field utilizing a quadrupole magnetic sorting. The results demonstrate that (1) preferential enrichment of porcine islets is achievable, but homogeneous bead distribution within the pancreas is difficult to achieve with current protocols; (2) greater than 70% of islets in the dissociated pancreatic tissue were recovered by quadrupole magnetic sorting, but their purity was low; and (3) infused islets purified by density gradients and subsequently passed through quadrupole magnetic sorting had similar potency as uninfused islets. These results demonstrate proof of concept and define the steps for implementation of this technology in pig and human islet isolation. PMID:19505179

Nuclear Magnetic Dipole and Electric Quadrupole Moments: Their Measurement and Tabulation as Accessible Data

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stone, N. J., E-mail: n.stone@physics.ox.ac.uk

The most recent tabulations of nuclear magnetic dipole and electric quadrupole moments have been prepared and published by the Nuclear Data Section of the IAEA, Vienna [N. J. Stone, Report No. INDC(NDS)-0650 (2013); Report No. INDC(NDS)-0658 (2014)]. The first of these is a table of recommended quadrupole moments for all isotopes in which all experimental results are made consistent with a limited number of adopted standards for each element; the second is a combined listing of all measurements of both moments. Both tables cover all isotopes and energy levels. In this paper, the considerations relevant to the preparation of bothmore » tables are described, together with observations as to the importance and (where appropriate) application of necessary corrections to achieve the “best” values. Some discussion of experimental methods is included with emphasis on their precision. The aim of the published quadrupole moment table is to provide a standard reference in which the value given for each moment is the best available and for which full provenance is given. A table of recommended magnetic dipole moments is in preparation, with the same objective in view.« less

Dynamics of vortex quadrupoles in nonrotating trapped Bose-Einstein condensates.

PubMed

Yang, Tao; Hu, Zhi-Qiang; Zou, Shan; Liu, Wu-Ming

2016-07-28

Dynamics of vortex clusters is essential for understanding diverse superfluid phenomena. In this paper, we examine the dynamics of vortex quadrupoles in a trapped two-dimensional (2D) Bose-Einstein condensate. We find that the movement of these vortex-clusters fall into three distinct regimes which are fully described by the radial positions of the vortices in a 2D isotropic harmonic trap, or by the major radius (minor radius) of the elliptical equipotential lines decided by the vortex positions in a 2D anisotropic harmonic trap. In the "recombination" and "exchange" regimes the quadrupole structure maintains, while the vortices annihilate each other permanently in the "annihilation" regime. We find that the mechanism of the charge flipping in the "exchange" regime and the disappearance of the quadrupole structure in the "annihilation" regime are both through an intermediate state where two vortex dipoles connected through a soliton ring. We give the parameter ranges for these three regimes in coordinate space for a specific initial configuration and phase diagram of the vortex positions with respect to the Thomas-Fermi radius of the condensate. We show that the results are also applicable to systems with quantum fluctuations for the short-time evolution.

Beyond the Boost: Measuring the Intrinsic Dipole of the Cosmic Microwave Background Using the Spectral Distortions of the Monopole and Quadrupole.

PubMed

Yasini, Siavash; Pierpaoli, Elena

2017-12-01

We present a general framework for the accurate spectral modeling of the low multipoles of the cosmic microwave background (CMB) as observed in a boosted frame. In particular, we demonstrate how spectral measurements of the low multipoles can be used to separate the motion-induced dipole of the CMB from a possible intrinsic dipole component. In a moving frame, the leakage of an intrinsic dipole moment into the CMB monopole and quadrupole induces spectral distortions with distinct frequency functions that, respectively, peak at 337 and 276 GHz. The leakage into the quadrupole moment also induces a geometrical distortion to the spatial morphology of this mode. The combination of these effects can be used to lift the degeneracy between the motion-induced dipole and any intrinsic dipole that the CMB might possess. Assuming the current peculiar velocity measurements, the leakage of an intrinsic dipole with an amplitude of ΔT=30  μK into the monopole and quadrupole moments will be detectable by a PIXIE-like experiment at ∼40  nK (2.5σ) and ∼130  nK (11σ) level at their respective peak frequencies.

Effect of Post-deformation Annealing Treatment on the Microstructural Evolution of a Cold-Worked Corrosion-Resistant Superalloy (CRSA) Steel

NASA Astrophysics Data System (ADS)

Mirzaei, A.; Zarei-Hanzaki, A.; Mohamadizadeh, A.; Lin, Y. C.

2018-03-01

The post-deformation annealing treatments of a commercial cold-worked corrosion-resistant superalloy steel (Sanicro 28 steel) were carried out at different temperatures in the range of 900-1100 °C for different holding durations of 5, 10, and 15 min. The effects of post-deformation annealing time and temperature on the microstructural evolution and subsequent mechanical properties of the processed Sanicro 28 steel were investigated. The observations indicated that twin-twin hardening in cold deformation condition mainly correlates with abundant nucleation of mechanical twins in multiple directions resulting in considerable strain hardening behavior. Microstructural investigations showed that the static recrystallization takes place after isothermal holding at 900 °C for 5 min. Increasing the annealing temperature from 900 to 1050 °C leads to recrystallization development and grain refinement in the as-recrystallized state. In addition, an increase in annealing duration from 5 to 15 min leads to subgrain coarsening and subsequently larger recrystallized grains size. The occurrence of large proportion of the grain refinement, which is achieved in the first annealing stage at 1050 °C after 5 min, is considered as the main factor for the maximum elongation at this stage.

Impact of temperature on childhood pneumonia estimated from satellite remote sensing.

PubMed

Xu, Zhiwei; Liu, Yang; Ma, Zongwei; Li, Shenghui; Hu, Wenbiao; Tong, Shilu

2014-07-01

The effect of temperature on childhood pneumonia in subtropical regions is largely unknown so far. This study examined the impact of temperature on childhood pneumonia in Brisbane, Australia. A quasi-Poisson generalized linear model combined with a distributed lag non-linear model was used to quantify the main effect of temperature on emergency department visits (EDVs) for childhood pneumonia in Brisbane from 2001 to 2010. The model residuals were checked to identify added effects due to heat waves or cold spells. Both high and low temperatures were associated with an increase in EDVs for childhood pneumonia. Children aged 2-5 years, and female children were particularly vulnerable to the impacts of heat and cold, and Indigenous children were sensitive to heat. Heat waves and cold spells had significant added effects on childhood pneumonia, and the magnitude of these effects increased with intensity and duration. There were changes over time in both the main and added effects of temperature on childhood pneumonia. Children, especially those female and Indigenous, should be particularly protected from extreme temperatures. Future development of early warning systems should take the change over time in the impact of temperature on children's health into account. Copyright © 2014 Elsevier Inc. All rights reserved.

Quality Evaluation of the Traditional Medicine Majun Mupakhi ELA via Chromatographic Fingerprinting Coupled with UHPLC-DAD-Quadrupole-Orbitrap-MS and the Antioxidant Activity In Vitro

PubMed Central

Reheman, Ayinuer; Ma, Qing Ling; Nijat, Dilaram; Abdulla, Rahima

2018-01-01

By merging a high-performance liquid chromatography diode array detector (HPLC-DAD) method with high-performance thin-layer chromatography (HPTLC), an assay was developed for chemical fingerprinting and quantitative analysis of traditional medicine Majun Mupakhi ELA (MME), and constituent compounds were identified using HPLC coupled with UHPLC-DAD-Quadrupole-Orbitrap-MS method. In addition, the antioxidant capacity of MME was assessed based on the ability of components to scavenge radicals using in vitro method. Using a HPLC-DAD method with HPTLC easily validated the chemical fingerprinting results and quantified three characteristic components, namely, gallic acid (1), daidzein (2), and icariin (3), in commercial MMEs. The three compounds presented excellent regression values (R2 = 0.9999) in the ranges of the test and the method recovery was in the range from 100.49% to 100.68%. The fingerprints had 27 common characteristic peaks, of which 13 were verified by rapid UHPLC-DAD-Q-Orbitrap-MS analysis. In vitro antioxidant assays rapidly assessed and contrasted antioxidant activity or the free radical scavenging activity of the main polyphenolic classes in MMEs, and the antioxidant capacity was mostly affected by the presence of gallic acid. Thus, this study establishes a powerful and meaningful approach for MME quality control and for assessing in vitro antioxidant activity. PMID:29692853

Systematic chemical profiling of Citrus grandis 'Tomentosa' by ultra-fast liquid chromatography/diode-array detector/quadrupole time-of-flight tandem mass spectrometry.

PubMed

Li, Pan-lin; Liu, Meng-hua; Hu, Jie-hui; Su, Wei-wei

2014-03-01

Citrus grandis 'Tomentosa', as the original plant of the traditional Chinese medicine "Huajuhong", has been used as antitussive and expectorant in clinic for thousands of years. The fruit epicarp and whole fruit of this plant were both literarily recorded and commonly used. In the present study, an ultra-fast liquid chromatography coupled with diode-array detection and quadrupole/time-of-flight mass spectrometry (UFLC-DAD-Q-TOF-MS/MS) based chemical profiling method was developed for rapid holistic quality evaluation of C. grandis 'Tomentosa', which laid basis for chemical comparison of two medicinal parts. As a result, forty-eight constituents, mainly belonging to flavonoids and coumarins, were unambiguously identified by comparison with reference standards and/or tentatively characterized by elucidating UV spectra, quasi-molecular ions and fragment ions referring to information available in literature. Both of the epicarp and whole fruit samples were rich in flavonoids and coumarins, but major flavonoids contents in whole fruit were significantly higher than in epicarp (P<0.5). The proposed method could be useful in quality control and standardization of C. grandis 'Tomentosa' raw materials and its products. Results obtained in this study will provide a basis for quality assessment and further study in vivo. Copyright © 2013 Elsevier B.V. All rights reserved.

Quantification and semiquantification of multiple representative components for the holistic quality control of Allii Macrostemonis Bulbus by ultra high performance liquid chromatography with quadrupole time-of-flight tandem mass spectrometry.

PubMed

Qin, Zifei; Lin, Pei; Dai, Yi; Yao, Zhihong; Wang, Li; Yao, Xinsheng; Liu, Liyin; Chen, Haifeng

2016-05-01

Allii Macrostemonis Bulbus (named Xiebai in China) is a folk medicine with medicinal values for the treatment of thoracic obstruction and cardialgia, and a food additive as well. However, there is even no quantitative standard for Allii Macrostemonis Bulbus recorded in the current edition of the Chinese Pharmacopeia. Hence, simultaneous assay of multiple components is urgent. In this study, chemometric methods were firstly applied to discover the components with significant fluctuation among multiple Allii Macrostemonis Bulbus samples based on optimized fingerprints. Meanwhile, the major components and main absorbed components in rats were all selected as its representative components. Subsequently, a sensitive method was established for the simultaneous determination of 54 components (15 components for quantification and 39 components for semiquantification) by ultra high performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry. Moreover, the validated method was successfully applied to evaluate the quality of multiple samples on the market. It became known that multiple Allii Macrostemonis Bulbus samples varied significantly and showed poor consistency. This work illustrated that the proposed approach could improve the quality of Allii Macrostemonis Bulbus, and it also provided a feasible method for quality evaluation of other traditional Chinese medicines. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Quality Evaluation of the Traditional Medicine Majun Mupakhi ELA via Chromatographic Fingerprinting Coupled with UHPLC-DAD-Quadrupole-Orbitrap-MS and the Antioxidant Activity In Vitro.

PubMed

Reheman, Ayinuer; Aisa, Haji Akber; Ma, Qing Ling; Nijat, Dilaram; Abdulla, Rahima

2018-01-01

By merging a high-performance liquid chromatography diode array detector (HPLC-DAD) method with high-performance thin-layer chromatography (HPTLC), an assay was developed for chemical fingerprinting and quantitative analysis of traditional medicine Majun Mupakhi ELA (MME), and constituent compounds were identified using HPLC coupled with UHPLC-DAD-Quadrupole-Orbitrap-MS method. In addition, the antioxidant capacity of MME was assessed based on the ability of components to scavenge radicals using in vitro method. Using a HPLC-DAD method with HPTLC easily validated the chemical fingerprinting results and quantified three characteristic components, namely, gallic acid (1), daidzein (2), and icariin (3), in commercial MMEs. The three compounds presented excellent regression values ( R 2 = 0.9999) in the ranges of the test and the method recovery was in the range from 100.49% to 100.68%. The fingerprints had 27 common characteristic peaks, of which 13 were verified by rapid UHPLC-DAD-Q-Orbitrap-MS analysis. In vitro antioxidant assays rapidly assessed and contrasted antioxidant activity or the free radical scavenging activity of the main polyphenolic classes in MMEs, and the antioxidant capacity was mostly affected by the presence of gallic acid. Thus, this study establishes a powerful and meaningful approach for MME quality control and for assessing in vitro antioxidant activity.

Saw & seal, airport pavement.

DOT National Transportation Integrated Search

2009-05-01

Due to extreme cold temperatures, hot bituminous pavements on Maines airports are subject to transverse : or thermal cracking. This can lead to poorly performing pavement structure causing heaving and : settlement problems. Studies have shown that...

Comparative study between cold air analgesia and supraorbital and supratrochlear nerve block for the management of pain during photodynamic therapy for actinic keratoses of the frontotemporal zone.

PubMed

Serra-Guillen, C; Hueso, L; Nagore, E; Vila, M; Llombart, B; Requena Caballero, C; Botella-Estrada, R; Sanmartin, O; Alfaro-Rubio, A; Guillen, C

2009-08-01

Photodynamic therapy (PDT) is an effective treatment for actinic keratoses, Bowen's disease and basal cell carcinoma. The main drawback of PDT is pain during application. To compare the efficacy of supratrochlear and supraorbital nerve block with cold air analgesia to control the pain experienced during PDT. A controlled open clinical trial was conducted in 34 patients having multiple actinic keratoses in the frontal region treated with PDT. On one side of the frontal region the supratrochlear and supraorbital nerves were blocked, while on the other side cold air was used as the method of analgesia. Pain was recorded on a visual analogue scale after treatment. Thirty-one of 34 patients reported less pain in the zone treated with nerve block. This difference was statistically significant. Nerve block is superior to cold air and is an easy, safe, effective means of controlling the pain associated with PDT.

Brown adipose tissue responds to cold and adrenergic stimulation by induction of FGF21.

PubMed

Chartoumpekis, Dionysios V; Habeos, Ioannis G; Ziros, Panos G; Psyrogiannis, Agathoklis I; Kyriazopoulou, Venetsana E; Papavassiliou, Athanasios G

2011-01-01

Fibroblast growth factor-21 (FGF21) is a pleiotropic protein involved in glucose, lipid metabolism and energy homeostasis, with main tissues of expression being the liver and adipose tissue. Brown adipose tissue (BAT) is responsible for cold-induced thermogenesis in rodents. The role of FGF21 in BAT biology has not been investigated. In the present study, wild-type C57BL/6J mice as well as a brown adipocyte cell line were used to explore the potential role of cold exposure and β3-adrenergic stimulation in the expression of FGF21 in BAT. Our results demonstrate that short-term exposure to cold, as well as β3-adrenergic stimulation, causes a significant induction of FGF21 mRNA levels in BAT, without a concomitant increase in FGF21 plasma levels. This finding opens new routes for the potential use of pharmaceuticals that could induce FGF21 and, hence, activate BAT thermogenesis.

Seismic evidence for a cold serpentinized mantle wedge beneath Mount St Helens

PubMed Central

Hansen, S. M.; Schmandt, B.; Levander, A.; Kiser, E.; Vidale, J. E.; Abers, G. A.; Creager, K. C.

2016-01-01

Mount St Helens is the most active volcano within the Cascade arc; however, its location is unusual because it lies 50 km west of the main axis of arc volcanism. Subduction zone thermal models indicate that the down-going slab is decoupled from the overriding mantle wedge beneath the forearc, resulting in a cold mantle wedge that is unlikely to generate melt. Consequently, the forearc location of Mount St Helens raises questions regarding the extent of the cold mantle wedge and the source region of melts that are responsible for volcanism. Here using, high-resolution active-source seismic data, we show that Mount St Helens sits atop a sharp lateral boundary in Moho reflectivity. Weak-to-absent PmP reflections to the west are attributed to serpentinite in the mantle-wedge, which requires a cold hydrated mantle wedge beneath Mount St Helens (<∼700 °C). These results suggest that the melt source region lies east towards Mount Adams. PMID:27802263

[Factors affecting the vegetation restoration after fires in cold temperate wetlands: A review].

PubMed

Zhao, Feng-Jun; Wang, Li-Zhong; Shu, Li-Fu; Chen, Peng-Yu; Chen, Li-guang

2013-03-01

Cold temperate wetland plays an important role in maintaining regional ecological balance. Fire is an important disturbance factor in wetland ecosystem. Severe burning can induce the marked degradation of the ecological functions of wetland ecosystem. The vegetation restoration, especially the early vegetation restoration, after fires, is the premise and basis for the recovery of the ecological functions of the ecosystem. This paper reviewed the research progress on the factors affecting the vegetation restoration after fires in wetlands. The vegetation restoration after fires in cold temperate wetlands was controlled by the fire intensity, fire size, vegetation types before fires, regeneration characteristics of plant species, and site conditions. It was considered that the long-term monitoring on the post-fire vegetation restoration in cold temperate wetland, the key factors affecting the vegetation restoration, the roles of frozen soil layer on the post-fire vegetation restoration, and the theories and technologies on the vegetation restoration would be the main research directions in the future.

Effects of Thermo-Mechanical Treatments on Deformation Behavior and IGSCC Susceptibility of Stainless Steels in Pwr Primary Water Chemistry

NASA Astrophysics Data System (ADS)

Nouraei, S.; Tice, D. R.; Mottershead, K. J.; Wright, D. M.

Field experience of 300 series stainless steels in the primary circuit of PWR plant has been good. Stress Corrosion Cracking of components has been infrequent and mainly associated with contamination by impurities/oxygen in occluded locations. However, some instances of failures have been observed which cannot necessarily be attributed to deviations in the water chemistry. These failures appear to be associated with the presence of cold-work produced by surface finishing and/or by welding-induced shrinkage. Recent data indicate that some heats of SS show an increased susceptibility to SCC; relatively high crack growth rates were observed even when the crack growth direction is orthogonal to the cold-work direction. SCC of cold-worked SS in PWR coolant is therefore determined by a complex interaction of material composition, microstructure, prior cold-work and heat treatment. This paper will focus on the interactions between these parameters on crack propagation in simulated PWR conditions.

Simple model for deriving sdg interacting boson model Hamiltonians: 150Nd example

NASA Astrophysics Data System (ADS)

Devi, Y. D.; Kota, V. K. B.

1993-07-01

A simple and yet useful model for deriving sdg interacting boson model (IBM) Hamiltonians is to assume that single-boson energies derive from identical particle (pp and nn) interactions and proton, neutron single-particle energies, and that the two-body matrix elements for bosons derive from pn interaction, with an IBM-2 to IBM-1 projection of the resulting p-n sdg IBM Hamiltonian. The applicability of this model in generating sdg IBM Hamiltonians is demonstrated, using a single-j-shell Otsuka-Arima-Iachello mapping of the quadrupole and hexadecupole operators in proton and neutron spaces separately and constructing a quadrupole-quadrupole plus hexadecupole-hexadecupole Hamiltonian in the analysis of the spectra, B(E2)'s, and E4 strength distribution in the example of 150Nd.

Injector Design for a Model Electron Ring at the University of Maryland

NASA Astrophysics Data System (ADS)

Godlove, T.; Bernal, S.; Deng, J. J.; Li, Y.; Reiser, M.; Wang, J. G.; Zou, Y.

1997-05-01

A model electron recirculator is being developed at the University of Maryland. It employs a 10-keV, space-charge-dominated beam injected into a 1.8-m radius ring equipped with a strong-focusing lattice based on printed-circuit quadrupoles and dipoles. The motivation and general features are described in separate papers. Here we describe the design for injecting a single-turn bunch into the ring. The system includes a low-emittance e-gun, matching section, pulsed dipole and Panofsky quadrupole. The dipole at the injection point must deflect the beam -10^circ during entry and +10^circ after entry, with about 25 ns transition time. The Panofsky quadrupole must be off during entry and on for subsequent laps, with a similar rise time.

Source-to-accelerator quadrupole matching section for a compact linear accelerator

NASA Astrophysics Data System (ADS)

Seidl, P. A.; Persaud, A.; Ghiorso, W.; Ji, Q.; Waldron, W. L.; Lal, A.; Vinayakumar, K. B.; Schenkel, T.

2018-05-01

Recently, we presented a new approach for a compact radio-frequency (RF) accelerator structure and demonstrated the functionality of the individual components: acceleration units and focusing elements. In this paper, we combine these units to form a working accelerator structure: a matching section between the ion source extraction grids and the RF-acceleration unit and electrostatic focusing quadrupoles between successive acceleration units. The matching section consists of six electrostatic quadrupoles (ESQs) fabricated using 3D-printing techniques. The matching section enables us to capture more beam current and to match the beam envelope to conditions for stable transport in an acceleration lattice. We present data from an integrated accelerator consisting of the source, matching section, and an ESQ doublet sandwiched between two RF-acceleration units.

An analytical study of double bend achromat lattice.

PubMed

Fakhri, Ali Akbar; Kant, Pradeep; Singh, Gurnam; Ghodke, A D

2015-03-01

In a double bend achromat, Chasman-Green (CG) lattice represents the basic structure for low emittance synchrotron radiation sources. In the basic structure of CG lattice single focussing quadrupole (QF) magnet is used to form an achromat. In this paper, this CG lattice is discussed and an analytical relation is presented, showing the limitation of basic CG lattice to provide the theoretical minimum beam emittance in achromatic condition. To satisfy theoretical minimum beam emittance parameters, achromat having two, three, and four quadrupole structures is presented. In this structure, different arrangements of QF and defocusing quadruple (QD) are used. An analytical approach assuming quadrupoles as thin lenses has been followed for studying these structures. A study of Indus-2 lattice in which QF-QD-QF configuration in the achromat part has been adopted is also presented.

Microwave spectra and quadrupole coupling measurements for methyl rhenium trioxide

NASA Astrophysics Data System (ADS)

Sickafoose, S. M.; Wikrent, P.; Drouin, B. J.; Kukolich, S. G.

1996-12-01

Microwave rotational transitions for J' ← J = 1 ← 0 and 2 ← 1 were measured in the 6-14 GHz range for methyl rhenium trioxide using a Flygare-Balle type, pulsed-beam spectrometer. The rotational constants for the most abundant isotopomers are B( 187Re) = 3466.964(2) MHz and B( 185Re) = 3467.049(3) MHz. The quadrupole coupling strengths are eQq( 187Re) = 716.55(2) MHz and eQq( 185Re) = 757.19(3) MHz. Transitions were also observed for 13C isotopomers and 18O isotopomers. The value for the ReC bond length obtained from a Kraitchman analysis is R( ReC) = 2.080 Å. The rhenium quadrupole coupling strengths are about 20% smaller than those obtained for HRe(CO) 5.

Presence of 3d quadrupole moment in LaTiO3 studied by 47,49Ti NMR.

PubMed

Kiyama, Takashi; Itoh, Masayuki

2003-10-17

47,49Ti NMR spectra of LaTiO3 are reexamined and the orbital state of this compound is discussed. The NMR spectra of LaTiO3 taken at 1.5 K under zero external field indicate a large nuclear quadrupole splitting. This splitting is ascribed to the presence of the rather large quadrupole moment of 3d electrons at Ti sites, suggesting that the orbital liquid model proposed for LaTiO3 is inappropriate. The NMR spectra are well explained by the orbital ordering model expressed approximately as 1/square root of 3(d(xy)+d(yz)+d(zx)) originating from a crystal field effect. It is also shown that most of the orbital moment is quenched.

Mössbauer spectroscopic characterization of iron methyl pyropheophorbide a and its derivatives

NASA Astrophysics Data System (ADS)

Inoue, H.; Soeda, K.; Akahori, H.; Nonomura, Y.; Yoshioka, N.

1994-12-01

Two kinds of iron chlorophylls, i.e. (methyl pyropheophorbide a)iron(III) chloride and its bis-pyridine adduct, were prepared and characterized by57Fe Mössbauer spectroscopy. (Methyl pyropheophorbide a)iron(III) chloride gave an asymmetric quadrupole-split doublet typical of high-spin iron(III) chlorophylls, while its bis-pyridine adduct showed a symmetric quadrupole-split doublet characteristic of low-spin iron(II) chlorophylls. The isomer shift and quadrupole splitting obtained for (methyl pyropheophorbide a)iron(III) chloride and its bis-pyridine adduct have led to the following conclusions. The substitution of the bulky phytyl group for the methyl group hardly affects the electronic state of the iron(II,III) ion, but the elimination of the methoxycarbonyl group increases the planarity of the macrocyclic chlorin ligand.

Spin coherent states phenomena probed by quantum state tomography in Zeeman perturbed nuclear quadrupole resonance

NASA Astrophysics Data System (ADS)

Teles, João; Auccaise, Ruben; Rivera-Ascona, Christian; Araujo-Ferreira, Arthur G.; Andreeta, José P.; Bonagamba, Tito J.

2018-07-01

Recently, we reported an experimental implementation of quantum information processing (QIP) by nuclear quadrupole resonance (NQR). In this work, we present the first quantum state tomography (QST) experimental implementation in the NQR QIP context. Two approaches are proposed, employing coherence selection by temporal and spatial averaging. Conditions for reduction in the number of cycling steps are analyzed, which can be helpful for larger spin systems. The QST method was applied to the study of spin coherent states, where the alignment-to-orientation phenomenon and the evolution of squeezed spin states show the effect of the nonlinear quadrupole interaction intrinsic to the NQR system. The quantum operations were implemented using a single-crystal sample of KClO3 and observing ^{35}Cl nuclei, which posses spin 3/2.

Quadrupole collectivity beyond N = 50 in neutron- rich Se and Kr isotopes

NASA Astrophysics Data System (ADS)

Elman, Brandon; Gade, A.; Barofsky, D.; Bender, P. C.; Bowry, M.; Hjorth-Jensen, M.; Kemper, K. W.; Lipschutz, S.; Lunderberg, E.; Sachmpazidi, N.; Terpstra, N.; Walters, W. B.; Weisshaar, D.; Westerberg, A.; Williams, S. J.; Wimmer, K.

2017-09-01

We will present results on measuring the B (E 2 ;01+ ->2n+) strength for the neutron-rich 88,90Kr and 86Se isotopes from intermediate-energy Coulomb excitation. The electric quadrupole transition strengths to the first 2+ state complete, with considerably improved uncertainties, the evolution of quadrupole collectivity in the Kr and Se isotopes approaching N = 60 , for which 90Kr and 86Se had previously been the most uncertain. We also report significant excitation strength to several higher lying 2+ states in the krypton isotopes. The results confirm shell model calculations in the π (fpg) - ν (sdg) shell with only a minimally tuned shell model setup that is based on a nucleon-nucleon interaction derived from effective field theory with effective charges adjusted to 86Kr.

Magnetic field generation from shear flow in flux ropes

NASA Astrophysics Data System (ADS)

Intrator, T. P.; Sears, J.; Gao, K.; Klarenbeek, J.; Yoo, C.

2012-10-01

In the Reconnection Scaling Experiment (RSX) we have measured out of plane quadrupole magnetic field structure in situations where magnetic reconnection was minimal. This quadrupole out of plane magnetic signature has historically been presumed to be the smoking gun harbinger of reconnection. On the other hand, we showed that when flux ropes bounced instead of merging and reconnecting, this signature could evolve. This can follow from sheared fluid flows in the context of a generalized Ohms Law. We reconstruct a shear flow model from experimental data for flux ropes that have been experimentally well characterized in RSX as screw pinch equilibria, including plasma ion and electron flow, with self consistent profiles for magnetic field, pressure, and current density. The data can account for the quadrupole field structure.

A note on the electric quadrupole and higher electric moments of ozone (O3)

NASA Astrophysics Data System (ADS)

Maroulis, George

2012-02-01

We have obtained accurate ab initio and density functional theory values for the quadrupole, octopole and hexadecapole electric moments of the cyclic and open forms of ozone. Our best values have been calculated at the coupled cluster level of theory with molecule-specific basis sets. For the quadrupole moment (Θαβ/ea02) they are Θyy = -1.366 (cyclic), Θxx = -1.202, Θyy = 1.426 and Θxx = -0.223 (open). For the octopole (Ωαβγ/ea03) and hexadecapole (Φαβγδ/ea04) moments our best results are Ωzzz = 2.25, Φyyyy = 19.53 (cyclic), Ωxxz = 3.28, Ωzzz = -2.97, Φxxxx = -6.00, Φyyyy = -3.90 and Φzzzz = -3.54 (open).

Support Structure Design of the $$\\hbox{Nb}_{3}\\hbox{Sn}$$ Quadrupole for the High Luminosity LHC

DOE PAGES

Juchno, M.; Ambrosio, G.; Anerella, M.; ...

2014-10-31

New low-β quadrupole magnets are being developed within the scope of the High Luminosity LHC (HL-LHC) project in collaboration with the US LARP program. The aim of the HLLHC project is to study and implement machine upgrades necessary for increasing the luminosity of the LHC. The new quadrupoles, which are based on the Nb₃Sn superconducting technology, will be installed in the LHC Interaction Regions and will have to generate a gradient of 140 T/m in a coil aperture of 150 mm. In this paper, we describe the design of the short model magnet support structure and discuss results of themore » detailed 3D numerical analysis performed in preparation for the first short model test.« less

A specific glycerol kinase induces rapid cold hardening of the diamondback moth, Plutella xylostella.

PubMed

Park, Youngjin; Kim, Yonggyun

2014-08-01

Insects in temperate zones survive low temperatures by migrating or tolerating the cold. The diamondback moth, Plutella xylostella, is a serious insect pest on cabbage and other cruciferous crops worldwide. We showed that P. xylostella became cold-tolerant by expressing rapid cold hardiness (RCH) in response to a brief exposure to moderately low temperature (4°C) for 7h along with glycerol accumulation in hemolymph. Glycerol played a crucial role in the cold-hardening process because exogenously supplying glycerol significantly increased the cold tolerance of P. xylostella larvae without cold acclimation. To determine the genetic factor(s) responsible for RCH and the increase of glycerol, four glycerol kinases (GKs), and glycerol-3-phosphate dehydrogenase (PxGPDH) were predicted from the whole P. xylostella genome and analyzed for their function associated with glycerol biosynthesis. All predicted genes were expressed, but differed in their expression during different developmental stages and in different tissues. Expression of the predicted genes was individually suppressed by RNA interference (RNAi) using double-stranded RNAs specific to target genes. RNAi of PxGPDH expression significantly suppressed RCH and glycerol accumulation. Only PxGK1 among the four GKs was responsible for RCH and glycerol accumulation. Furthermore, PxGK1 expression was significantly enhanced during RCH. These results indicate that a specific GK, the terminal enzyme to produce glycerol, is specifically inducible during RCH to accumulate the main cryoprotectant. Copyright © 2014 Elsevier Ltd. All rights reserved.

UHPLC/Q-TOFMS-based metabolomics for the characterization of cold and hot properties of Chinese materia medica.

PubMed

Wang, Yang; Zhou, Shujun; Wang, Meng; Liu, Shuying; Hu, Yuanjia; He, Chengwei; Li, Peng; Wan, Jian-Bo

2016-02-17

The cold/hot property of Chinese materia medica (CMM) and the application of its corresponding knowledge in the diagnosis, differentiation and treatment of diseases have been considered to be the extremely important part of traditional Chinese medicine (TCM). As highly abstracted TCM theory, the cold/hot property of CMMs is still not fully understood and remains to be elucidated by systems biology approach. The cold and hot properties of CMM are mainly defined by the response of the body to a given CMM. Metabolomics is a promising systems biology method to profile entire endogenous metabolites and monitor their fluctuations related to an exogenous stimulus. Thus, a metabolomics approach was applied to characterize the cold and hot properties of CMMs. Mice were intragastrically administered three selected cold property CMMs (i.e., Rheum palmatum L., radix et rhizoma; Coptis chinensis Franch, rhizome and Scutellaria baicalensis Georgi, radix) and three hot property CMMs (i.e., Cinnamomum cassia (L.) J. Presl, cortex; Zingiber officinale Roscoe, rhizoma and Evodia rutaecarpa (Juss.) Benth., fructus) once daily for one week. The comprehensive metabolome changes in the plasma of mice after treatment with cold or hot property CMMs were characterized by ultra-high performance liquid chromatography/time of flight mass spectrometry (UHPLC/Q-TOF-MS), and the potential biomarkers related to cold and hot properties of CMM were explored. Metabolites perturbation in plasma occurs after treatment with cold CMMs and hot CMMs in mice, and 15 and 16 differential biomarkers were identified to be associated with the cold and hot properties of CMMs, respectively. Among them, LPC (18:0), LPC (18:1), LPC (20:4) and LPC (20:5) showed decreased trends in the cold property CMM treated groups, but increased in the hot property CMM treated groups. There is a strong connection between the cold/hot property of CMMs and lysophosphatidylcholines metabolism. This study offers new insight into CMM properties and their clinical application. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Differential gene expression profiling through transcriptome approach of Saccharum spontaneum L. under low temperature stress reveals genes potentially involved in cold acclimation.

PubMed

Selvarajan, Dharshini; Mohan, Chakravarthi; Dhandapani, Vignesh; Nerkar, Gauri; Jayanarayanan, Ashwin Narayan; Vadakkancherry Mohanan, Manoj; Murugan, Naveenarani; Kaur, Lovejot; Chennappa, Mahadevaiah; Kumar, Ravinder; Meena, Minturam; Ram, Bakshi; Chinnaswamy, Appunu

2018-04-01

Sugarcane ( Saccharum sp.) is predominantly grown in both tropics and subtropics in India, and the subtropics alone contribute more than half of sugarcane production. Sugarcane active growth period in subtropics is restricted to 8-9 months mainly due to winter's low temperature stress prevailing during November to February every year. Being a commercial crop, tolerance to low temperature is important in sugarcane improvement programs. Development of cold tolerant sugarcane varieties require a deep knowledge on molecular mechanism naturally adapted by cold tolerant genotypes during low temperature stress. To understand gene regulation under low temperature stress, control and stressed (10 °C, 24 h) leaf samples of cold tolerant S. spontaneum IND 00-1037 collected from high altitude region in Arunachal Pradesh were used for transcriptome analysis using the Illumina NextSeq 500 platform with paired-end sequencing method. Raw reads of 5.1 GB (control) and 5.3 GB (stressed) obtained were assembled using trinity and annotated with UNIPROT, KEGG, GO, COG and SUCEST databases, and transcriptome was validated using qRT-PCR. The differential gene expression (DGE) analysis showed that 2583 genes were upregulated and 3302 genes were down-regulated upon low temperature stress. A total of 170 cold responsive transcriptional factors belonging to 30 families were differentially regulated. CBF6 (C-binding factor), a DNA binding transcriptional activation protein associated with cold acclimation and freezing tolerance was differentially upregulated. Many low temperature responsive genes involved in various metabolic pathways, viz. cold sensing through membrane fluidity, calcium and lipid signaling genes, MAP kinases, phytohormone signaling and biosynthetic genes, antioxidative enzymes, membrane and cellular stabilizing genes, genes involved in biosynthesis of polyunsaturated fatty acids, chaperones, LEA proteins, soluble sugars, osmoprotectants, lignin and pectin biosynthetic genes were also differentially upregulated. Potential cold responsive genes and transcriptional factors involved in cold tolerance mechanism in cold tolerant S. spontaneum IND 00-1037 were identified. Together, this study provides insights into the cold tolerance to low temperature stress in S. spontaneum , thus opening applications in the genetic improvement of cold stress tolerance in sugarcane.

PHARAO flight model: optical on ground performance tests

NASA Astrophysics Data System (ADS)

Lévèque, T.; Faure, B.; Esnault, F. X.; Grosjean, O.; Delaroche, C.; Massonnet, D.; Escande, C.; Gasc, Ph.; Ratsimandresy, A.; Béraud, S.; Buffe, F.; Torresi, P.; Larivière, Ph.; Bernard, V.; Bomer, T.; Thomin, S.; Salomon, C.; Abgrall, M.; Rovera, D.; Moric, I.; Laurent, Ph.

2017-11-01

PHARAO (Projet d'Horloge Atomique par Refroidissement d'Atomes en Orbite), which has been developed by CNES, is the first primary frequency standard specially designed for operation in space. PHARAO is the main instrument of the ESA mission ACES (Atomic Clock Ensemble in Space). ACES payload will be installed on-board the International Space Station (ISS) to perform fundamental physics experiments. All the sub-systems of the Flight Model (FM) have now passed the qualification process and the whole FM of the cold cesium clock, PHARAO, is being assembled and will undergo extensive tests. The expected performances in space are frequency accuracy less than 3.10-16 (with a final goal at 10-16) and frequency stability of 10-13 τ-1/2. In this paper, we focus on the laser source performances and the main results on the cold atom manipulation.

Colors of Inner Disk Classical Kuiper Belt Objects

NASA Astrophysics Data System (ADS)

Romanishin, W.; Tegler, S. C.; Consolmagno, G. J.

2010-07-01

We present new optical broadband colors, obtained with the Keck 1 and Vatican Advanced Technology telescopes, for six objects in the inner classical Kuiper Belt. Objects in the inner classical Kuiper Belt are of interest as they may represent the surviving members of the primordial Kuiper Belt that formed interior to the current position of the 3:2 resonance with Neptune, the current position of the plutinos, or, alternatively, they may be objects formed at a different heliocentric distance that were then moved to their present locations. The six new colors, combined with four previously published, show that the ten inner belt objects with known colors form a neutral clump and a reddish clump in B-R color. Nonparametric statistical tests show no significant difference between the B-R color distribution of the inner disk objects compared to the color distributions of Centaurs, plutinos, or scattered disk objects. However, the B-R color distribution of the inner classical Kuiper Belt Objects does differ significantly from the distribution of colors in the cold (low inclination) main classical Kuiper Belt. The cold main classical objects are predominately red, while the inner classical belt objects are a mixture of neutral and red. The color difference may reveal the existence of a gradient in the composition and/or surface processing history in the primordial Kuiper Belt, or indicate that the inner disk objects are not dynamically analogous to the cold main classical belt objects.

COLORS OF INNER DISK CLASSICAL KUIPER BELT OBJECTS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Romanishin, W.; Tegler, S. C.; Consolmagno, G. J., E-mail: wromanishin@ou.ed, E-mail: Stephen.Tegler@nau.ed, E-mail: gjc@specola.v

2010-07-15

We present new optical broadband colors, obtained with the Keck 1 and Vatican Advanced Technology telescopes, for six objects in the inner classical Kuiper Belt. Objects in the inner classical Kuiper Belt are of interest as they may represent the surviving members of the primordial Kuiper Belt that formed interior to the current position of the 3:2 resonance with Neptune, the current position of the plutinos, or, alternatively, they may be objects formed at a different heliocentric distance that were then moved to their present locations. The six new colors, combined with four previously published, show that the ten innermore » belt objects with known colors form a neutral clump and a reddish clump in B-R color. Nonparametric statistical tests show no significant difference between the B-R color distribution of the inner disk objects compared to the color distributions of Centaurs, plutinos, or scattered disk objects. However, the B-R color distribution of the inner classical Kuiper Belt Objects does differ significantly from the distribution of colors in the cold (low inclination) main classical Kuiper Belt. The cold main classical objects are predominately red, while the inner classical belt objects are a mixture of neutral and red. The color difference may reveal the existence of a gradient in the composition and/or surface processing history in the primordial Kuiper Belt, or indicate that the inner disk objects are not dynamically analogous to the cold main classical belt objects.« less

Cold atom quantum sensors for space

NASA Astrophysics Data System (ADS)

Singh, Yeshpal

2016-07-01

Quantum sensors based on cold atoms offer the opportunity to perform highly accurate measurements of physical phenomena related to time, gravity and rotation. The deployment of such technologies in the microgravity environment of space may enable further enhancement of their performance, whilst permitting the detection of these physical phenomena over much larger scales than is possible with a ground-based instrument. In this talk, I will present an overview of the activities of the UK National Quantum Hub in Sensors and Metrology in developing cold atoms technology for space. Our activities are focused in two main areas: optical clocks and atom interferometers. I will also discuss our contributions to recent initiatives including STE-QUEST and AI-GOAT, the ESA/NASA initiative aiming at an atom interferometer gravitational wave detector in space.

Investigation of the microstructure of Ni and B4C ceramic-metal mixtures obtained by cold spray coating and followed by laser cladding

NASA Astrophysics Data System (ADS)

Filippov, A. A.; Fomin, V. M.; Orishich, A. M.; Malikov, A. G.; Ryashin, N. S.; Golyshev, A. A.

2017-10-01

In the present work, a combined method is considered for the production of a metal-matrix composite coating based on Ni and B4C. The coating is created by consistently applied methods: cold spray and laser cladding. Main focus of this work aimed to microstructure of coatings, element content and morphology of laser tracks. At this stage, the authors focused on the interaction of the laser unit with the substance without affecting the layer-growing technology products. It is shown that coating has deformed particles of nickel and the significantly decreased content of ceramic particles B4C after cold spray. After laser cladding there are no boundaries between nickel and dramatically changes in ceramic particles.

Dull Brains and Frozen Feet: A Historical Essay on Cold.

PubMed

Lankford, Harvey V

2016-12-01

This essay will review historical and medical aspects of cold exposure, hypothermia, and frostbite during the Napoleonic era. The 19th century writings of Dominique Jean Larrey, Pierre Jean Moricheau-Beaupré, and others are used to provide an evocative supporting narrative to illustrate some of the cold illnesses, physiology, and theory of both an earlier era and the present time. Medical care for over a century followed the how but not the why of treating frostbite and hypothermia slowly with snow or cold water rather than heat. There were 2 main reasons: First was a practical attempt to limit gangrene. Less known, and long forgotten, is a major rationale based on the erroneous theory of heat called "the caloric." Because of these 2 reasons, the slow method of "cold warming" remained standard medical practice well into the 20th century. Although these recommendations are now known to be flawed, some of the reasons behind them will be discussed, along with early but correct observations on afterdrop and circumrescue collapse. There is a long backstory of treatment from 1812 to the present. Copyright © 2016 Wilderness Medical Society. Published by Elsevier Inc. All rights reserved.

Role of the cold water on the formation of the East Korean Warm Current in the East/Japan Sea : A numerical experiment

NASA Astrophysics Data System (ADS)

Kim, Y.; Kim, Y. H.; Cho, Y. K.

2016-12-01

The East/Japan Sea (EJS) is a marginal sea of the western Pacific with an average depth of 2,000 m. The water exchange between the EJS and the Pacific occurs through the Korea Strait and Tsugaru Strait corresponding to the inlet and outlet respectively. The Tsushima Current flowing into the ESJ through the Korea Strait is divided into two main branches, the Nearshore Branch flowing along the Japanese coast, and the East Korean Warm Current (EKWC) heading northward along the Korean coast. Many previous studies reported the effects of cold water on the formation of the EKWC using 2-dimensional model that was limited in the Korea Strait. However, 3-dimensional structure of the cold water in relation to the EKWC have not been examined. In this study, we investigated the effects of cold water on the formation of the EKWC using 3-dimension numerical model. Model results indicate that the thickness and relative vorticity of the upper layer decrease due to the presence of the lower cold water along the Korean coast. Correspondingly, the negative relative vorticity also intensifies the EKWC along the Korean coast.

Echinacea for preventing and treating the common cold

PubMed Central

Karsch-Völk, Marlies; Barrett, Bruce; Kiefer, David; Bauer, Rudolf; Ardjomand-Woelkart, Karin; Linde, Klaus

2014-01-01

Background Echinacea plant preparations (family Asteraceae) are widely used in Europe and North America for common colds. Most consumers and physicians are not aware that products available under the term Echinacea differ appreciably in their composition, mainly due to the use of variable plant material, extraction methods and the addition of other components. Objectives To assess whether there is evidence that Echinacea preparations are effective and safe compared to placebo in the prevention and treatment of the common cold. Search methods We searched CENTRAL 2013, Issue 5, MEDLINE (1946 to May week 5, 2013), EMBASE (1991 to June 2013), CINAHL (1981 to June 2013), AMED (1985 to February 2012), LILACS (1981 to June 2013), Web of Science (1955 to June 2013), CAMBASE (no time limits), the Centre for Complementary Medicine Research (1988 to September 2007), WHO ICTRP and clinicaltrials.gov (last searched 5 June 2013), screened references and asked experts in the field about published and unpublished studies. Selection criteria Randomized controlled trials (RCTs) comparing mono-preparations of Echinacea with placebo. Data collection and analysis At least two review authors independently assessed eligibility and trial quality and extracted data. The primary efficacy outcome was the number of individuals with at least one cold in prevention trials and the duration of colds in treatment trials. For all included trials the primary safety and acceptability outcome was the number of participants dropping out due to adverse events. We assessed trial quality using the Cochrane ’Risk of bias’ tool. Main results Twenty-four double-blind trials with 4631 participants including a total of 33 comparisons of Echinacea preparations and placebo met the inclusion criteria. A variety of different Echinacea preparations based on different species and parts of plant were used. Evidence from seven trials was available for preparations based on the aerial parts of Echinacea purpurea. Ten trials were considered to have a low risk of bias, six to have an unclear risk of bias and eight to have a high risk of bias. Ten trials with 13 comparisons investigated prevention and 15 trials with 20 comparisons investigated treatment of colds (one trial addressed both prevention and treatment). Due to the strong clinical heterogeneity of the studies we refrained from pooling for the main analysis. None of the 12 prevention comparisons reporting the number of patients with at least one cold episode found a statistically significant difference. However a post hoc pooling of their results, suggests a relative risk reduction of 10% to 20%. Of the seven treatment trials reporting data on the duration of colds, only one showed a significant effect of Echinacea over placebo. The number of patients dropping out or reporting adverse effects did not differ significantly between treatment and control groups in prevention and treatment trials. However, in prevention trials there was a trend towards a larger number of patients dropping out due to adverse events in the treatment groups. Authors’ conclusions Echinacea products have not here been shown to provide benefits for treating colds, although, it is possible there is a weak benefit from some Echinacea products: the results of individual prophylaxis trials consistently show positive (if non-significant) trends, although potential effects are of questionable clinical relevance. PMID:24554461

Radiological restrictions of using red mud as building material additive.

PubMed

Gu, Hannian; Wang, Ning; Liu, Shirong

2012-09-01

Red mud remains as residue from the processing of bauxite using different methods. The chemical composition of red mud varies widely with respect to the types of bauxite ore and processing parameters. Red mud samples from Guizhou, China, were investigated using a X-ray fluorescence spectroscope, a quadrupole inductively coupled plasma mass spectrometer and a electron probe micro-analyzer. The results showed that red mud consisted of eight main chemical components--CaO, Al(2)O(3), SiO(2), Fe(2)O(3), TiO(2), Na(2)O, K(2)O and MgO--and dozens of trace elements, including natural radioactive elements, such as uranium and thorium. Gamma spectrometric analysis showed that the values of internal exposure index I (Ra) and external exposure index I (γ) of Guizhou red mud were 1.1-2.4 and 2.3-3.5 respectively. Thus, it should not be used as a main building material indiscriminately. The amount of red mud from Guizhou when it is used for main building materials in China should be less than 28-44%.

Extreme hydrometeorological events in the Peruvian Central Andes during austral summer and their relationship with the large-scale circulation

NASA Astrophysics Data System (ADS)

Sulca, Juan C.

In this Master's dissertation, atmospheric circulation patterns associated with extreme hydrometeorological events in the Mantaro Basin, Peruvian Central Andes, and their teleconnections during the austral summer (December-January-February-March) are addressed. Extreme rainfall events in the Mantaro basin are related to variations of the large-scale circulation as indicated by the changing strength of the Bolivian High-Nordeste Low (BH-NL) system. Dry (wet) spells are associated with a weakening (strengthening) of the BH-NL system and reduced (enhanced) influx of moist air from the lowlands to the east due to strengthened westerly (easterly) wind anomalies at mid- and upper-tropospheric levels. At the same time extreme rainfall events of the opposite sign occur over northeastern Brazil (NEB) due to enhanced (inhibited) convective activity in conjunction with a strengthened (weakened) Nordeste Low. Cold episodes in the Mantaro Basin are grouped in three types: weak, strong and extraordinary cold episodes. Weak and strong cold episodes in the MB are mainly associated with a weakening of the BH-NL system due to tropical-extratropical interactions. Both types of cold episodes are associated with westerly wind anomalies at mid- and upper-tropospheric levels aloft the Peruvian Central Andes, which inhibit the influx of humid air masses from the lowlands to the east and hence limit the potential for development of convective cloud cover. The resulting clear sky conditions cause nighttime temperatures to drop, leading to cold extremes below the 10-percentile. Extraordinary cold episodes in the MB are associated with cold and dry polar air advection at all tropospheric levels toward the central Peruvian Andes. Therefore, weak and strong cold episodes in the MB appear to be caused by radiative cooling associated with reduced cloudiness, rather than cold air advection, while the latter plays an important role for extraordinary cold episodes only.

The temperature-productivity squeeze: Constraints on brook trout growth along an Appalachian river continuum

USGS Publications Warehouse

Petty, J. Todd; Thorne, David; Huntsman, Brock M.; Mazik, Patricia M.

2014-01-01

We tested the hypothesis that brook trout growth rates are controlled by a complex interaction of food availability, water temperature, and competitor density. We quantified trout diet, growth, and consumption in small headwater tributaries characterized as cold with low food and high trout density, larger tributaries characterized as cold with moderate food and moderate trout density, and large main stems characterized as warm with high food and low trout density. Brook trout consumption was highest in the main stem where diets shifted from insects in headwaters to fishes and crayfish in larger streams. Despite high water temperatures, trout growth rates also were consistently highest in the main stem, likely due to competitively dominant trout monopolizing thermal refugia. Temporal changes in trout density had a direct negative effect on brook trout growth rates. Our results suggest that competition for food constrains brook trout growth in small streams, but access to thermal refugia in productive main stem habitats enables dominant trout to supplement growth at a watershed scale. Brook trout conservation in this region should seek to relieve the “temperature-productivity squeeze,” whereby brook trout productivity is constrained by access to habitats that provide both suitable water temperature and sufficient prey.

Machine detector interface studies: Layout and synchrotron radiation estimate in the future circular collider interaction region

DOE Office of Scientific and Technical Information (OSTI.GOV)

Boscolo, Manuela; Burkhardt, Helmut; Sullivan, Michael

The interaction region layout for the e +e – future circular collider FCC-ee is presented together with a preliminary estimate of synchrotron radiation that affects this region. We describe in this paper the main guidelines of this design and the estimate of synchrotron radiation coming from the last bending magnets and from the final focus quadrupoles, with the software tools developed for this purpose. Here, the design follows the asymmetric optics layout as far as incoming bend radiation is concerned with the maximum foreseen beam energy of 175 GeV and we present a feasible initial layout with an indication ofmore » tolerable synchrotron radiation.« less

Heavy-ion injector based on an electron cyclotron ion source for the superconducting linear accelerator of the Rare Isotope Science Project.

PubMed

Hong, In-Seok; Kim, Yong-Hwan; Choi, Bong-Hyuk; Choi, Suk-Jin; Park, Bum-Sik; Jin, Hyun-Chang; Kim, Hye-Jin; Heo, Jeong-Il; Kim, Deok-Min; Jang, Ji-Ho

2016-02-01

The injector for the main driver linear accelerator of the Rare Isotope Science Project in Korea, has been developed to allow heavy ions up to uranium to be delivered to the inflight fragmentation system. The critical components of the injector are the superconducting electron cyclotron resonance (ECR) ion sources, the radio frequency quadrupole (RFQ), and matching systems for low and medium energy beams. We have built superconducting magnets for the ECR ion source, and a prototype with one segment of the RFQ structure, with the aim of developing a design that can satisfy our specifications, demonstrate stable operation, and prove results to compare the design simulation.

Radiation Field Forming for Industrial Electron Accelerators Using Rare-Earth Magnetic Materials

NASA Astrophysics Data System (ADS)

Ermakov, A. N.; Khankin, V. V.; Shvedunov, N. V.; Shvedunov, V. I.; Yurov, D. S.

2016-09-01

The article describes the radiation field forming system for industrial electron accelerators, which would have uniform distribution of linear charge density at the surface of an item being irradiated perpendicular to the direction of its motion. Its main element is non-linear quadrupole lens made with the use of rare-earth magnetic materials. The proposed system has a number of advantages over traditional beam scanning systems that use electromagnets, including easier product irradiation planning, lower instantaneous local dose rate, smaller size, lower cost. Provided are the calculation results for a 10 MeV industrial electron accelerator, as well as measurement results for current distribution in the prototype build based on calculations.

Machine detector interface studies: Layout and synchrotron radiation estimate in the future circular collider interaction region

DOE PAGES

Boscolo, Manuela; Burkhardt, Helmut; Sullivan, Michael

2017-01-27

The interaction region layout for the e +e – future circular collider FCC-ee is presented together with a preliminary estimate of synchrotron radiation that affects this region. We describe in this paper the main guidelines of this design and the estimate of synchrotron radiation coming from the last bending magnets and from the final focus quadrupoles, with the software tools developed for this purpose. Here, the design follows the asymmetric optics layout as far as incoming bend radiation is concerned with the maximum foreseen beam energy of 175 GeV and we present a feasible initial layout with an indication ofmore » tolerable synchrotron radiation.« less

NQR: From imaging to explosives and drugs detection

NASA Astrophysics Data System (ADS)

Osán, Tristán M.; Cerioni, Lucas M. C.; Forguez, José; Ollé, Juan M.; Pusiol, Daniel J.

2007-02-01

The main aim of this work is to present an overview of the nuclear quadrupole resonance (NQR) spectroscopy capabilities for solid state imaging and detection of illegal substances, such as explosives and drugs. We briefly discuss the evolution of different NQR imaging techniques, in particular those involving spatial encoding which permit conservation of spectroscopic information. It has been shown that plastic explosives and other forbidden substances cannot be easily detected by means of conventional inspection techniques, such as those based on conventional X-ray technology. For this kind of applications, the experimental results show that the information inferred from NQR spectroscopy provides excellent means to perform volumetric and surface detection of dangerous explosive and drug compounds.

Phase analysis of Košice meteorite: Preliminary results

NASA Astrophysics Data System (ADS)

Sitek, J.; Dekan, J.; Degmová, J.; Sedlačková, K.

2012-10-01

Meteorite fall was observed by the Košice town in Slovakia in February 2010 and it was classified as an ordinary chondrite H5. The samples were prepared in powder form scratched from the surface. Mossbauer spectra were measured at room temperature and liquid nitrogen temperature. Spectra consist of components related to iron-bearing phases with different content. Non-magnetic part was fitted with three quadrupole doublets. According to its parameters, we identified olivine, pyroxene, and traces of Fe3+ phases. Magnetic part consists of an iron-rich Fe-Ni alloy with hyperfine magnetic field similar to kamacite α-Fe(Ni,Co) and troilite. Main elements were also determined by X-ray fluorescence spectroscopy.

NQRS Data for C24H20BRb (Subst. No. 1578)

NASA Astrophysics Data System (ADS)

Chihara, H.; Nakamura, N.

This document is part of Subvolume B 'Substances Containing C10H16 … Zn' of Volume 48 'Nuclear Quadrupole Resonance Spectroscopy Data' of Landolt-Börnstein - Group III 'Condensed Matter'. It contains an extract of Section '3.2 Data tables' of the Chapter '3 Nuclear quadrupole resonance data' providing the NQRS data for C24H20BRb (Subst. No. 1578)

NQRS Data for CoLa4LiO8(Subst. No. 1970)

NASA Astrophysics Data System (ADS)

Chihara, H.; Nakamura, N.

This document is part of Subvolume B 'Substances Containing C10H16 … Zn' of Volume 48 'Nuclear Quadrupole Resonance Spectroscopy Data' of Landolt-Börnstein - Group III 'Condensed Matter'. It contains an extract of Section '3.2 Data tables' of the Chapter '3 Nuclear quadrupole resonance data' providing the NQRS data for CoLa4LiO8 (Subst. No. 1970)

Nqrs Data for C2H5NO2 (Subst. No. 0554)

NASA Astrophysics Data System (ADS)

Chihara, H.; Nakamura, N.

This document is part of Subvolume A `Substances Containing Ag … C10H15' of Volume 48 `Nuclear Quadrupole Resonance Spectroscopy Data' of Landolt-Börnstein - Group III `Condensed Matter'. It contains an extract of Section `3.2 Data tables' of the Chapter `3 Nuclear quadrupole resonance data' providing the NQRS data for C2H5NO2 (Subst. No. 0554)

NQRS Data for Ga3LaPd2 (Subst. No. 2229)

NASA Astrophysics Data System (ADS)

Chihara, H.; Nakamura, N.

This document is part of Subvolume B 'Substances Containing C10H16 … Zn' of Volume 48 'Nuclear Quadrupole Resonance Spectroscopy Data' of Landolt-Börnstein - Group III 'Condensed Matter'. It contains an extract of Section '3.2 Data tables' of the Chapter '3 Nuclear quadrupole resonance data' providing the NQRS data for Ga3LaPd2 (Subst. No. 2229)

NQRS Data for AlDO28Si13 (Subst. No. 0033)

NASA Astrophysics Data System (ADS)

Chihara, H.; Nakamura, N.

This document is part of Subvolume A `Substances Containing Ag … C10H15' of Volume 48 `Nuclear Quadrupole Resonance Spectroscopy Data' of Landolt-Börnstein - Group III `Condensed Matter'. It contains an extract of Section `3.2 Data tables' of the Chapter `3 Nuclear quadrupole resonance data' providing the NQRS data for AlDO28Si13 (Subst. No. 0033)

NQRS Data for AlDO70Si34 (Subst. No. 0035)

NASA Astrophysics Data System (ADS)

Chihara, H.; Nakamura, N.

This document is part of Subvolume A `Substances Containing Ag … C10H15' of Volume 48 `Nuclear Quadrupole Resonance Spectroscopy Data' of Landolt-Börnstein - Group III `Condensed Matter'. It contains an extract of Section `3.2 Data tables' of the Chapter `3 Nuclear quadrupole resonance data' providing the NQRS data for AlDO70Si34 (Subst. No. 0035)

NQRS Data for AlDO28Si13 (Subst. No. 0034)

NASA Astrophysics Data System (ADS)

Chihara, H.; Nakamura, N.

This document is part of Subvolume A `Substances Containing Ag … C10H15' of Volume 48 `Nuclear Quadrupole Resonance Spectroscopy Data' of Landolt-Börnstein - Group III `Condensed Matter'. It contains an extract of Section `3.2 Data tables' of the Chapter `3 Nuclear quadrupole resonance data' providing the NQRS data for AlDO28Si13 (Subst. No. 0034)

NQRS Data for AlDO2 [Al(OD)O] (Subst. No. 0032)

NASA Astrophysics Data System (ADS)

Chihara, H.; Nakamura, N.

This document is part of Subvolume A `Substances Containing Ag … C10H15' of Volume 48 `Nuclear Quadrupole Resonance Spectroscopy Data' of Landolt-Börnstein - Group III `Condensed Matter'. It contains an extract of Section `3.2 Data tables' of the Chapter `3 Nuclear quadrupole resonance data' providing the NQRS data for AlDO2 [Al(OD)O] (Subst. No. 0032)

Conceptual Design Study of Nb(3)Sn Low-beta Quadrupoles for 2nd Generation LHC IRs

NASA Astrophysics Data System (ADS)

Zlobin, A. V.; Ambrosio, G.; Andreev, N.; Barzi, E.; Bauer, P.

2002-10-01

Conceptual designs of 90-mm aperture high gradient quadrupoles based on the Nb3Sn superconductor, are being developed at Fermilab for possible 2nd generation IRs with the similar optics as in the current low-beta insertions. Magnet designs and results of magnetic, mechanical, thermal and quench protection analysis for these magnets are presented and discussed.

Velocity damper for electromagnetically levitated materials

DOEpatents

Fox, Richard J.

1994-01-01

A system for damping oscillatory and spinning motions induced in an electromagnetically levitated material. Two opposed field magnets are located orthogonally to the existing levitation coils for providing a DC quadrupole field (cusp field) around the material. The material used for generating the DC quadrupole field must be nonconducting to avoid eddy-current heating and of low magnetic permeability to avoid distorting the induction fields providing the levitation.

Diverse accumulation of several dehydrin-like proteins in cauliflower (Brassica oleracea var. botrytis), Arabidopsis thaliana and yellow lupin (Lupinus luteus) mitochondria under cold and heat stress.

PubMed

Rurek, Michal

2010-08-18

Dehydrins represent hydrophilic proteins acting mainly during cell dehydration and stress response. Dehydrins are generally thermostable; however, the so-called dehydrin-like (dehydrin-related) proteins show variable thermolability. Both groups immunoreact with antibodies directed against the K-segment of dehydrins. Plant mitochondrial dehydrin-like proteins are poorly characterized. The purpose of this study was to extend previous reports on plant dehydrins by comparing the level of immunoprecipitated dehydrin-like proteins in cauliflower (Brassica oleracea var. botrytis), Arabidopsis thaliana and yellow lupin (Lupinus luteus) mitochondria under cold and heat stress. All the analyzed plant species showed constitutive accumulation of thermostable mitochondrial putative dehydrins ranging from 50 to 70 kDa. The mitochondrial dehydrin-like proteins observed in cauliflower and Arabidopsis ranged from 10 to 100 kDa and in lupin imbibed seeds and hypocotyls--from 20 to 90 kDa. Cold treatment increased mainly the accumulation of 10-100 kDa cauliflower and Arabidopsis dehydrin-like proteins, in the patterns different in cauliflower leaf and inflorescence mitochondria. However, in lupin mitochondria, cold affected mainly 25-50 kDa proteins and seemed to induce the appearance of some novel dehydrin-like proteins. The influence of frost stress on cauliflower leaf mitochondrial dehydrin- like proteins was less significant. The impact of heat stress was less significant in lupin and Arabidopsis than in cauliflower inflorescence mitochondria. Cauliflower mitochondrial dehydrin-like proteins are localized mostly in the mitochondrial matrix; it seems that some of them may interact with mitochondrial membranes. All the results reveal an unexpectedly broad spectrum of dehydrin-like proteins accumulated during some abiotic stress in the mitochondria of the plant species analyzed. They display only limited similarity in size to those reported previously in maize, wheat and rye mitochondria. Some small thermolabile dehydrin-like proteins were induced under stress conditions applied and therefore they are likely to be involved in stress response.

Diverse accumulation of several dehydrin-like proteins in cauliflower (Brassica oleracea var. botrytis), Arabidopsis thaliana and yellow lupin (Lupinus luteus) mitochondria under cold and heat stress

PubMed Central

2010-01-01

Background Dehydrins represent hydrophilic proteins acting mainly during cell dehydration and stress response. Dehydrins are generally thermostable; however, the so-called dehydrin-like (dehydrin-related) proteins show variable thermolability. Both groups immunoreact with antibodies directed against the K-segment of dehydrins. Plant mitochondrial dehydrin-like proteins are poorly characterized. The purpose of this study was to extend previous reports on plant dehydrins by comparing the level of immunoprecipitated dehydrin-like proteins in cauliflower (Brassica oleracea var. botrytis), Arabidopsis thaliana and yellow lupin (Lupinus luteus) mitochondria under cold and heat stress. Results All the analyzed plant species showed constitutive accumulation of thermostable mitochondrial putative dehydrins ranging from 50 to 70 kDa. The mitochondrial dehydrin-like proteins observed in cauliflower and Arabidopsis ranged from 10 to 100 kDa and in lupin imbibed seeds and hypocotyls - from 20 to 90 kDa. Cold treatment increased mainly the accumulation of 10-100 kDa cauliflower and Arabidopsis dehydrin-like proteins, in the patterns different in cauliflower leaf and inflorescence mitochondria. However, in lupin mitochondria, cold affected mainly 25-50 kDa proteins and seemed to induce the appearance of some novel dehydrin-like proteins. The influence of frost stress on cauliflower leaf mitochondrial dehydrin- like proteins was less significant. The impact of heat stress was less significant in lupin and Arabidopsis than in cauliflower inflorescence mitochondria. Cauliflower mitochondrial dehydrin-like proteins are localized mostly in the mitochondrial matrix; it seems that some of them may interact with mitochondrial membranes. Conclusions All the results reveal an unexpectedly broad spectrum of dehydrin-like proteins accumulated during some abiotic stress in the mitochondria of the plant species analyzed. They display only limited similarity in size to those reported previously in maize, wheat and rye mitochondria. Some small thermolabile dehydrin-like proteins were induced under stress conditions applied and therefore they are likely to be involved in stress response. PMID:20718974

[Qualitative and quantitative analysis of amygdalin and its metabolite prunasin in plasma by ultra-high performance liquid chromatography-tandem quadrupole time of flight mass spectrometry and ultra-high performance liquid chromatography-tandem triple quadrupole mass spectrometry].

PubMed

Gao, Meng; Wang, Yuesheng; Wei, Huizhen; Ouyang, Hui; He, Mingzhen; Zeng, Lianqing; Shen, Fengyun; Guo, Qiang; Rao, Yi

2014-06-01

A method was developed for the determination of amygdalin and its metabolite prunasin in rat plasma after intragastric administration of Maxing shigan decoction. The analytes were identified by ultra-high performance liquid chromatography-tandem quadrupole time of flight mass spectrometry and quantitatively determined by ultra-high performance liquid chromatography-tandem triple quadrupole mass spectrometry. After purified by liquid-liquid extraction, the qualitative analysis of amygdalin and prunasin in the plasma sample was performed on a Shim-pack XR-ODS III HPLC column (75 mm x 2.0 mm, 1.6 microm), using acetonitrile-0.1% (v/v) formic acid aqueous solution. The detection was performed on a Triple TOF 5600 quadrupole time of flight mass spectrometer. The quantitative analysis of amygdalin and prunasin in the plasma sample was performed by separation on an Agilent C18 HPLC column (50 mm x 2.1 mm, 1.7 microm), using acetonitrile-0.1% (v/v) formic acid aqueous solution. The detection was performed on an AB Q-TRAP 4500 triple quadrupole mass spectrometer utilizing electrospray ionization (ESI) interface operated in negative ion mode and multiple-reaction monitoring (MRM) mode. The qualitative analysis results showed that amygdalin and its metabolite prunasin were detected in the plasma sample. The quantitative analysis results showed that the linear range of amygdalin was 1.05-4 200 ng/mL with the correlation coefficient of 0.999 0 and the linear range of prunasin was 1.25-2 490 ng/mL with the correlation coefficient of 0.997 0. The method had a good precision with the relative standard deviations (RSDs) lower than 9.20% and the overall recoveries varied from 82.33% to 95.25%. The limits of detection (LODs) of amygdalin and prunasin were 0.50 ng/mL. With good reproducibility, the method is simple, fast and effective for the qualitative and quantitative analysis of the amygdalin and prunasin in plasma sample of rats which were administered by Maxing shigan decoction.

Non-Linear Cosmological Power Spectra in Real and Redshift Space

NASA Technical Reports Server (NTRS)

Taylor, A. N.; Hamilton, A. J. S.

1996-01-01

We present an expression for the non-linear evolution of the cosmological power spectrum based on Lagrangian trajectories. This is simplified using the Zel'dovich approximation to trace particle displacements, assuming Gaussian initial conditions. The model is found to exhibit the transfer of power from large to small scales expected in self-gravitating fields. Some exact solutions are found for power-law initial spectra. We have extended this analysis into red-shift space and found a solution for the non-linear, anisotropic redshift-space power spectrum in the limit of plane-parallel redshift distortions. The quadrupole-to-monopole ratio is calculated for the case of power-law initial spectra. We find that the shape of this ratio depends on the shape of the initial spectrum, but when scaled to linear theory depends only weakly on the redshift-space distortion parameter, beta. The point of zero-crossing of the quadrupole, kappa(sub o), is found to obey a simple scaling relation and we calculate this scale in the Zel'dovich approximation. This model is found to be in good agreement with a series of N-body simulations on scales down to the zero-crossing of the quadrupole, although the wavenumber at zero-crossing is underestimated. These results are applied to the quadrupole-to-monopole ratio found in the merged QDOT plus 1.2-Jy-IRAS redshift survey. Using a likelihood technique we have estimated that the distortion parameter is constrained to be beta greater than 0.5 at the 95 percent level. Our results are fairly insensitive to the local primordial spectral slope, but the likelihood analysis suggests n = -2 un the translinear regime. The zero-crossing scale of the quadrupole is k(sub 0) = 0.5 +/- 0.1 h Mpc(exp -1) and from this we infer that the amplitude of clustering is sigma(sub 8) = 0.7 +/- 0.05. We suggest that the success of this model is due to non-linear redshift-space effects arising from infall on to caustic and is not dominated by virialized cluster cores. The latter should start to dominate on scales below the zero-crossing of the quadrupole, where our model breaks down.

Working Around Cosmic Variance: Remote Quadrupole Measurements of the CMB

NASA Astrophysics Data System (ADS)

Adil, Arsalan; Bunn, Emory

2018-01-01

Anisotropies in the CMB maps continue to revolutionize our understanding of the Cosmos. However, the statistical interpretation of these anisotropies is tainted with a posteriori statistics. The problem is particularly emphasized for lower order multipoles, i.e. in the cosmic variance regime of the power spectrum. Naturally, the solution lies in acquiring a new data set – a rather difficult task given the sample size of the Universe.The CMB temperature, in theory, depends on: the direction of photon propagation, the time at which the photons are observed, and the observer’s location in space. In existing CMB data, only the first parameter varies. However, as first pointed out by Kamionkowski and Loeb, a solution lies in making the so-called “Remote Quadrupole Measurements” by analyzing the secondary polarization produced by incoming CMB photons via the Sunyaev-Zel’dovich (SZ) effect. These observations allow us to measure the projected CMB quadrupole at the location and look-back time of a galaxy cluster.At low redshifts, the remote quadrupole is strongly correlated to the CMB anisotropy from our last scattering surface. We provide here a formalism for computing the covariance and relation matrices for both the two-point correlation function on the last scattering surface of a galaxy cluster and the cross correlation of the remote quadrupole with the local CMB. We then calculate these matrices based on a fiducial model and a non-standard model that suppresses power at large angles for ~104 clusters up to z=2. We anticipate to make a priori predictions of the differences between our expectations for the standard and non-standard models. Such an analysis is timely in the wake of the CMB S4 era which will provide us with an extensive SZ cluster catalogue.

14N Quadrupole Coupling in the Microwave Spectra of N-Vinylformamide

NASA Astrophysics Data System (ADS)

Kannengießer, Raphaela; Stahl, Wolfgang; Nguyen, Ha Vinh Lam; Bailey, William C.

2016-06-01

The microwave spectra of two conformers, trans and cis, of the title compound were recorded using two molecular beam Fourier transform microwave spectrometers operating in the frequency range 2 GHz to 40 GHz, and aimed at analysis of their 14N quadrupole hyperfine structures. Rotational constants, centrifugal distortion constants, and nuclear quadrupole coupling constants (NQCCs) χaa and χbb - χcc, were all determined with very high accuracy. Two fits including 176 and 117 hyperfine transitions were performed for the trans and cis conformers, respectively. Standard deviations of both fits are close to the measurement accuracy of 2 kHz. The NQCCs of the two conformers are almost exactly the same, and are compared with values found for other saturated and unsaturated formamides. Complementary quantum chemical calculations - MP2/6-311++G(d,p) rotational constants, MP2/cc-pVTZ centrifugal distortion constants, and B3PW91/6-311+G(d,p)//MP2/6-311++G(d,p) nuclear quadrupole coupling constants - give spectroscopic parameters in excellent agreement with the experimental parameters. B3PW91/6-311+G(d,p) calculated electric field gradients, in conjunction with eQ/h = 4.599(12) MHz/a.u., yields more reliable NQCCs for formamides possessing conjugated π-electron systems than does the B3PW91/6-311+G(df,pd) model recommended in Ref., whereas this latter performs better for aliphatic formamides. We conclude from this that f-polarization functions on heavy atoms hinder rather than help with modeling of conjugated π-electron systems. W. C. Bailey, Chem. Phys., 2000, 252, 57 W. C. Bailey, Calculation of Nuclear Quadrupole Coupling Constants in Gaseous State Molecules, http://nqcc.wcbailey.net/index.html.

Critical comparison of mass analyzers for forensic hair analysis by ambient ionization mass spectrometry.

PubMed

Duvivier, Wilco F; van Beek, Teris A; Nielen, Michel W F

2016-11-15

Recently, several direct and/or ambient mass spectrometry (MS) approaches have been suggested for drugs of abuse imaging in hair. The use of mass spectrometers with insufficient selectivity could result in false-positive measurements due to isobaric interferences. Different mass analyzers have been evaluated regarding their selectivity and sensitivity for the detection of Δ9-tetrahydrocannabinol (THC) from intact hair samples using direct analysis in real time (DART) ionization. Four different mass analyzers, namely (1) an orbitrap, (2) a quadrupole orbitrap, (3) a triple quadrupole, and (4) a quadrupole time-of-flight (QTOF), were evaluated. Selectivity and sensitivity were assessed by analyzing secondary THC standard dilutions on stainless steel mesh screens and blank hair samples, and by the analysis of authentic cannabis user hair samples. Additionally, separation of isobaric ions by use of travelling wave ion mobility (TWIM) was investigated. The use of a triple quadrupole instrument resulted in the highest sensitivity; however, transitions used for multiple reaction monitoring were only found to be specific when using high mass resolution product ion measurements. A mass resolution of at least 30,000 FWHM at m/z 315 was necessary to avoid overlap of THC with isobaric ions originating from the hair matrix. Even though selectivity was enhanced by use of TWIM, the QTOF instrument in resolution mode could not indisputably differentiate THC from endogenous isobaric ions in drug user hair samples. Only the high resolution of the (quadrupole) orbitrap instruments and the QTOF instrument in high-resolution mode distinguished THC in hair samples from endogenous isobaric interferences. As expected, enhanced selectivity compromises sensitivity and THC was only detectable in hair from heavy users. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

BATSE Observations of the Large-Scale Isotropy of Gamma-Ray Bursts

NASA Technical Reports Server (NTRS)

Briggs, Michael S.; Paciesas, William S.; Pendleton, Geoffrey N.; Meegan, Charles A.; Fishman, Gerald J.; Horack, John M.; Brock, Martin N.; Kouveliotou, Chryssa; Hartmann, Dieter H.; Hakkila, Jon

1996-01-01

We use dipole and quadrupole statistics to test the large-scale isotropy of the first 1005 gamma-ray bursts observed by the Burst and Transient Source Experiment (BATSE). In addition to the entire sample of 1005 gamma-ray bursts, many subsets are examined. We use a variety of dipole and quadrupole statistics to search for Galactic and other predicted anisotropies and for anisotropies in a coordinate-system independent manner. We find the gamma-ray burst locations to be consistent with isotropy, e.g., for the total sample the observed Galactic dipole moment (cos theta) differs from the value predicted for isotropy by 0.9 sigma and the observed Galactic quadrupole moment (sin(exp 2) b - 1/3) by 0.3 sigma. We estimate for various models the anisotropies that could have been detected. If one-half of the locations were within 86 deg of the Galactic center, or within 28 deg of the Galactic plane, the ensuing dipole or quadrupole moment would have typically been detected at the 99% confidence level. We compare the observations with the dipole and quadrupole moments of various Galactic models. Several Galactic gamma-ray bursts models have moments within 2 sigma of the observations; most of the Galactic models proposed to date are no longer in acceptable agreement with the data. Although a spherical dark matter halo distribution could be consistent with the data, the required core radius is larger than the core radius of the dark matter halo used to explain the Galaxy's rotation curve. Gamma-ray bursts are much more isotropic than any observed Galactic population, strongly favoring but not requiring an origin at cosmological distances.

Evaluating Mass Analyzers as Candidates for Small, Portable, Rugged Single Point Mass Spectrometers for Analysis of Permanent Gases

NASA Technical Reports Server (NTRS)

Arkin, C. Richard; Ottens, Andrew K.; Diaz, Jorge A.; Griffin, Timothy P.; Follestein, Duke; Adams, Fredrick; Steinrock, T. (Technical Monitor)

2001-01-01

For Space Shuttle launch safety, there is a need to monitor the concentration of H2, He, O2 and Ar around the launch vehicle. Currently a large mass spectrometry system performs this task, using long transport lines to draw in samples. There is great interest in replacing this stationary system with several miniature, portable, rugged mass spectrometers which act as point sensors which can be placed at the sampling point. Five commercial and two non-commercial analyzers are evaluated. The five commercial systems include the Leybold Inficon XPR-2 linear quadrupole, the Stanford Research (SRS-100) linear quadrupole, the Ferran linear quadrupole array, the ThermoQuest Polaris-Q quadrupole ion trap, and the IonWerks Time-of-Flight (TOF). The non-commercial systems include a compact double focusing sector (CDFMS) developed at the University of Minnesota, and a quadrupole ion trap (UF-IT) developed at the University of Florida. The System Volume is determined by measuring the entire system volume including the mass analyzer, its associated electronics, the associated vacuum system, the high vacuum pump and rough pump. Also measured are any ion gauge controllers or other required equipment. Computers are not included. Scan Time is the time required for one scan to be acquired and the data to be transferred. It is determined by measuring the time required acquiring a known number of scans and dividing by said number of scans. Limit of Detection is determined first by performing a zero-span calibration (using a 10-point data set). Then the limit of detection (LOD) is defined as 3 times the standard deviation of the zero data set. (An LOD of 10 ppm or less is considered acceptable.)

Local hyperthermia benefits natural and experimental common colds.

PubMed Central

Tyrrell, D.; Barrow, I.; Arthur, J.

1989-01-01

OBJECTIVE--To determine whether inhaling fully humidified air at 43 degrees C gave more benefit to cold sufferers than inhaling air at 30 degrees C. DESIGN--Randomised double blind trial. Setting--General practice and the common cold research unit. SUBJECTS--87 Unselected patients with typical acute nasal and upper respiratory symptoms (general practice study), and 84 volunteers aged 18-50 without a history of chronic or allergic diseases. INTERVENTIONS--Subjects breathed from apparatus delivering 40 litres of room air heated to 43 degrees C or 30 degrees C and fully humidified (relative humidity 100%) per minute. End point--Reduction in severity of disease. MEASUREMENTS and main results--Patients recorded their symptoms (general practice study) and observers recorded symptoms and signs, weight of nasal secretions, isolation of virus, and antibody responses in volunteers. Patients treated for 20 minutes at 43 degrees C had in the succeeding days roughly half the score for symptoms of those treated at 30 degrees C. Volunteers treated for 30 minutes on three occasions when they were starting a cold showed an 18% [corrected] reduction in symptoms. Treatment of volunteers for 20 minutes at the onset of the cold and for 10 minutes on succeeding days showed no difference between 43 degrees C and 30 degrees C. CONCLUSIONS--Nasal hyperthermia can improve the course of a common cold and also give immediate relief of symptoms. PMID:2500196

Comparative Analysis of Anther Transcriptome Profiles of Two Different Rice Male Sterile Lines Genotypes under Cold Stress.

PubMed

Bai, Bin; Wu, Jun; Sheng, Wen-Tao; Zhou, Bo; Zhou, Li-Jie; Zhuang, Wen; Yao, Dong-Ping; Deng, Qi-Yun

2015-05-18

Rice is highly sensitive to cold stress during reproductive developmental stages, and little is known about the mechanisms of cold responses in rice anther. Using the HiSeq™ 2000 sequencing platform, the anther transcriptome of photo thermo sensitive genic male sterile lines (PTGMS) rice Y58S and P64S (Pei'ai64S) were analyzed at the fertility sensitive stage under cold stress. Approximately 243 million clean reads were obtained from four libraries and aligned against the oryza indica genome and 1497 and 5652 differentially expressed genes (DEGs) were identified in P64S and Y58S, respectively. Both gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were conducted for these DEGs. Functional classification of DEGs was also carried out. The DEGs common to both genotypes were mainly involved in signal transduction, metabolism, transport, and transcriptional regulation. Most of the DEGs were unique for each comparison group. We observed that there were more differentially expressed MYB (Myeloblastosis) and zinc finger family transcription factors and signal transduction components such as calmodulin/calcium dependent protein kinases in the Y58S comparison group. It was also found that ribosome-related DEGs may play key roles in cold stress signal transduction. These results presented here would be particularly useful for further studies on investigating the molecular mechanisms of rice responses to cold stress.

Comparative Analysis of Anther Transcriptome Profiles of Two Different Rice Male Sterile Lines Genotypes under Cold Stress

PubMed Central

Bai, Bin; Wu, Jun; Sheng, Wen-Tao; Zhou, Bo; Zhou, Li-Jie; Zhuang, Wen; Yao, Dong-Ping; Deng, Qi-Yun

2015-01-01

Rice is highly sensitive to cold stress during reproductive developmental stages, and little is known about the mechanisms of cold responses in rice anther. Using the HiSeq™ 2000 sequencing platform, the anther transcriptome of photo thermo sensitive genic male sterile lines (PTGMS) rice Y58S and P64S (Pei’ai64S) were analyzed at the fertility sensitive stage under cold stress. Approximately 243 million clean reads were obtained from four libraries and aligned against the oryza indica genome and 1497 and 5652 differentially expressed genes (DEGs) were identified in P64S and Y58S, respectively. Both gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were conducted for these DEGs. Functional classification of DEGs was also carried out. The DEGs common to both genotypes were mainly involved in signal transduction, metabolism, transport, and transcriptional regulation. Most of the DEGs were unique for each comparison group. We observed that there were more differentially expressed MYB (Myeloblastosis) and zinc finger family transcription factors and signal transduction components such as calmodulin/calcium dependent protein kinases in the Y58S comparison group. It was also found that ribosome-related DEGs may play key roles in cold stress signal transduction. These results presented here would be particularly useful for further studies on investigating the molecular mechanisms of rice responses to cold stress. PMID:25993302

Mood and selective attention in the cold: the effect of interval versus continuous exercise.

PubMed

Muller, Matthew D; Muller, Sarah M; Kim, Chul-Ho; Ryan, Edward J; Gunstad, John; Glickman, Ellen L

2011-07-01

Both mood and cognitive function are altered in cold environments. Body warming through exercise may improve Stroop interference score and lessen total negative mood. The purpose of this study was to determine the effect of equal caloric bouts of interval (INT) and continuous (CONT) exercise on mood and selective attention in the cold. Eleven young men underwent two experimental trials in 5°C air. Both trials consisted of 90 min acute cold exposure (ACE), 30 min exercise (INT vs. CONT), and 60 min recovery (REC). The Profile of Mood States (POMS) and Stroop Color Word Test (SCWT) were administered at four time points. Mean body temperature decreased during ACE, increased during exercise, and decreased during REC. Repeated measures analysis of variance revealed a main effect for time for several of the POMS sub scores. In particular, negative mood was significantly decreased after exercise relative to ACE and then significantly increased during REC. Further, CONT appears to be more effective than INT at decreasing negative mood. Components of the SCWT supported both the arousal and distraction theories for simple perception, but no significant effects were shown for the interference score. In the cold, exercise decreases negative mood but does not appear to affect selective attention. Further mechanistic studies could determine the best mode and intensity of exercise for improving cognitive function in the cold.

1. General oblique view of north and east sides, view ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. General oblique view of north and east sides, view to southwest, showing main loading docks - Fort Hood, World War II Temporary Buildings, Cold Storage Building, Seventeenth Street, Killeen, Bell County, TX

[Analysis of the Cochrane Review: Antihistamines for the Common Cold. Cochrane Database Syst Rev. 2015;11:CD009345].

PubMed

Sterrantino, Carmel; Duarte, Gonçalo; Costa, João; Vaz-Carneiro, António

2016-03-01

The common cold is an acute, self-limiting inflammation of the mucosa of the upper airways, which may involve one or all the sinuses, nasopharynx, oropharynx and larynx. It is common to have at least one episode per year. Common cold symptoms, which may include sore throat, sneezing, nasal congestion, runny nose, headache, malaise and mild fever usually disappear within a few days without treatment. The causative agent of most colds is rhinovirus. Although not associated with mortality, common cold is associated with significant morbidity. There is no vaccine or cure for common cold and, therefore, their treatment is centered on relieving the symptoms. This Cochrane review aimed to synthesize the existing evidence about the clinical benefit of antihistamines, used as monotherapy, compared with placebo or no treatment in children and adult patients with common cold. A total of 18 randomized clinical trials with 4342 participants were included. Main results were: 1) Antihistamines have a small (days one and two) beneficial effect in the short term on the severity of overall symptoms in adult patients, although this effect is not present in the medium to long term; 2) antihistamines were not associated with a clinically significant beneficial effect on the individual symptoms (nasal congestion, rhinorrhea, and sneezing); 3) Antihistamines are not associated with an increased risk of adverse effects; 4) No conclusion can be made about the effectiveness of antihistamines in pediatric populations. Our interpretation of the results is that the available evidence is insufficient to support the prescription or buying OTC antihistamines to relieve the symptoms of common cold without allergic component.

Application of a cold patch for relieving pain after transepithelial photorefractive keratectomy

PubMed Central

Zeng, Yuan; Li, Yi; Gao, Jian-Hua

2015-01-01

BACKGROUND: A return toward toward photorefractive keratectomy has occurred due to better corneal stability and fewer corneal flap complications; however, pain remains a major drawback of the procedure. Currently, clinical pain control measures focus on the administration of pain medications, which may delay corneal epithelial healing and has, occasionally, led to serious corneal toxicity. OBJECTIVES: To investigate the safety and efficacy of a cold patch on postoperative pain and other relevant consequences of transepithelial photorefractive keratectomy. METHODS: A prospective, randomized controlled study was conducted. Forty patients (80 eyes) scheduled to undergo transepithelial photorefractive keratectomy for myopia or myopic astigmatism were randomly and equally assigned to be treated with ice-cold balanced salt solution during surgery (wash group) or to wear a postoperative cold patch on the eye for 24 h. The main outcomes were pain score on a visual analogue scale, postoperative eyelid edema, conjunctival hyperemia, epithelial healing time, haze and postoperative best-corrected visual acuity. RESULTS: All patients completed the final tests. Demographic characteristics and pain scores during surgery were similar between the two groups. The mean postoperative pain scores of patients in the cold patch group at 8 h, 16 h and 24 h were significantly lower than those of patients in the wash group. Scores for postoperative eyelid edema and conjunctival hyperemia in the cold patch group were also lower than in the wash group. Patients in the cold patch group used fewer painkillers. Epithelial healing time, haze and early recovery of visual acuity were similar between the two groups. No eyelid frostbite was observed. CONCLUSION: Wearing a cold patch on the eye after transepithelial photorefractive keratectomy effectively relieved pain and inflammation, and reduced the use of painkillers without any side effects. PMID:25992866

Secondary Ion Mass Spectrometers (SIMS) for calcium isotope measurements as an application to biological samples

NASA Astrophysics Data System (ADS)

Craven, S. M.; Hoenigman, J. R.; Moddeman, W. E.

1981-11-01

The potential use of secondary ion mass spectroscopy (SIMS) to analyze biological samples for calcium isotopes is discussed. Comparison of UTI and Extranuclear based quadrupole systems is made on the basis of the analysis of CaO and calcium metal. The Extranuclear quadrupole based system is superior in resolution and sensitivity to the UTI system and is recommended. For determination of calcium isotopes to within an accuracy of a few percent a high resolution quadrupole, such as the Extranuclear, and signal averaging capability are required. Charge neutralization will be mandated for calcium oxide, calcium nitrate, or calcium oxalate. SIMS is not capable of the high precision and high accuracy results possible by thermal ionization methods, but where faster analysis is desirable with an accuracy of a few percent, SIMS is a viable alternative.

Demonstration of an ultrasensitive refractive-index plasmonic sensor by enabling its quadrupole resonance in phase interrogation.

PubMed

Lee, Hsin-Cheng; Li, Chung-Tien; Chen, How-Foo; Yen, Ta-Jen

2015-11-15

We present an ultrasensitive plasmonic sensing system by introducing a nanostructured X-shaped plasmonic sensor (XPS) and measuring its localized optical properties in phase interrogation. Our tailored XPS exhibits two major resonant modes of a low-order dipole and a high-order quadrupole, between which the quadrupole resonance allows an ultrahigh sensitivity, due to its higher quality factor. Furthermore, we design an in-house common-path phase-interrogation system, in contrast to conventional wavelength-interrogation methods, to achieve greater sensing capability. The experimental measurement shows that the sensing resolution of the XPS reaches 1.15×10(-6) RIU, not only two orders of magnitude greater than the result of the controlled extinction measurement (i.e., 9.90×10(-5) RIU), but also superior than current reported plasmonic sensors.