Science.gov

Sample records for major control point

  1. Galactosyltransferase 4 is a major control point for glycan branching in N-linked glycosylation

    PubMed Central

    McDonald, Andrew G.; Hayes, Jerrard M.; Bezak, Tania; Głuchowska, Sonia A.; Cosgrave, Eoin F. J.; Struwe, Weston B.; Stroop, Corné J. M.; Kok, Han; van de Laar, Teun; Rudd, Pauline M.; Tipton, Keith F.; Davey, Gavin P.

    2014-01-01

    ABSTRACT Protein N-glycosylation is a common post-translational modification that produces a complex array of branched glycan structures. The levels of branching, or antennarity, give rise to differential biological activities for single glycoproteins. However, the precise mechanism controlling the glycan branching and glycosylation network is unknown. Here, we constructed quantitative mathematical models of N-linked glycosylation that predicted new control points for glycan branching. Galactosyltransferase, which acts on N-acetylglucosamine residues, was unexpectedly found to control metabolic flux through the glycosylation pathway and the level of final antennarity of nascent protein produced in the Golgi network. To further investigate the biological consequences of glycan branching in nascent proteins, we glycoengineered a series of mammalian cells overexpressing human chorionic gonadotropin (hCG). We identified a mechanism in which galactosyltransferase 4 isoform regulated N-glycan branching on the nascent protein, subsequently controlling biological activity in an in vivo model of hCG activity. We found that galactosyltransferase 4 is a major control point for glycan branching decisions taken in the Golgi of the cell, which might ultimately control the biological activity of nascent glycoprotein. PMID:25271059

  2. ACCESS Pointing Control System

    NASA Technical Reports Server (NTRS)

    Brugarolas, Paul; Alexander, James; Trauger, John; Moody, Dwight; Egerman, Robert; Vallone, Phillip; Elias, Jason; Hejal, Reem; Camelo, Vanessa; Bronowicki, Allen; O'Connor, David; Partrick, Richard; Orzechowski, Pawel; Spitter, Connie; Lillie, Chuck

    2010-01-01

    ACCESS (Actively-Corrected Coronograph for Exoplanet System Studies) was one of four medium-class exoplanet concepts selected for the NASA Astrophysics Strategic Mission Concept Study (ASMCS) program in 2008/2009. The ACCESS study evaluated four major coronograph concepts under a common space observatory. This paper describes the high precision pointing control system (PCS) baselined for this observatory.

  3. ACCESS Pointing Control System

    NASA Technical Reports Server (NTRS)

    Brugarolas, Paul; Alexander, James; Trauger, John; Moody, Dwight; Egerman, Robert; Vallone, Phillip; Elias, Jason; Hejal, Reem; Camelo, Vanessa; Bronowicki, Allen; hide

    2010-01-01

    ACCESS (Actively-Corrected Coronograph for Exoplanet System Studies) was one of four medium-class exoplanet concepts selected for the NASA Astrophysics Strategic Mission Concept Study (ASMCS) program in 2008/2009. The ACCESS study evaluated four major coronograph concepts under a common space observatory. This paper describes the high precision pointing control system (PCS) baselined for this observatory.

  4. Floating Point Control Library

    SciTech Connect

    Lee, G. L.; Shereda, C.

    2007-08-02

    Floating Point Control is a Library that allows for the manipulation of floating point unit exception masking funtions control exceptions in both the Streaming "Single Instruction, Multiple Data" Extension 2 (SSE2) unit and the floating point unit simultaneously. FPC also provides macros to set floating point rounding and precision control.

  5. SPS antenna pointing control

    NASA Technical Reports Server (NTRS)

    Hung, J. C.

    1980-01-01

    The pointing control of a microwave antenna of the Satellite Power System was investigated emphasizing: (1) the SPS antenna pointing error sensing method; (2) a rigid body pointing control design; and (3) approaches for modeling the flexible body characteristics of the solar collector. Accuracy requirements for the antenna pointing control consist of a mechanical pointing control accuracy of three arc-minutes and an electronic phased array pointing accuracy of three arc-seconds. Results based on the factors considered in current analysis, show that the three arc-minute overall pointing control accuracy can be achieved in practice.

  6. Does point of care prothrombin time measurement reduce the transfusion of fresh frozen plasma in patients undergoing major surgery? The POC-OP randomized-controlled trial

    PubMed Central

    2009-01-01

    Background Bleeding is a frequent complication during surgery. The intraoperative administration of blood products, including packed red blood cells, platelets and fresh frozen plasma (FFP), is often live saving. Complications of blood transfusions contribute considerably to perioperative costs and blood product resources are limited. Consequently, strategies to optimize the decision to transfuse are needed. Bleeding during surgery is a dynamic process and may result in major blood loss and coagulopathy due to dilution and consumption. The indication for transfusion should be based on reliable coagulation studies. While hemoglobin levels and platelet counts are available within 15 minutes, standard coagulation studies require one hour. Therefore, the decision to administer FFP has to be made in the absence of any data. Point of care testing of prothrombin time ensures that one major parameter of coagulation is available in the operation theatre within minutes. It is fast, easy to perform, inexpensive and may enable physicians to rationally determine the need for FFP. Methods/Design The objective of the POC-OP trial is to determine the effectiveness of point of care prothrombin time testing to reduce the administration of FFP. It is a patient and assessor blind, single center randomized controlled parallel group trial in 220 patients aged between 18 and 90 years undergoing major surgery (any type, except cardiac surgery and liver transplantation) with an estimated blood loss during surgery exceeding 20% of the calculated total blood volume or a requirement of FFP according to the judgment of the physicians in charge. Patients are randomized to usual care plus point of care prothrombin time testing or usual care alone without point of care testing. The primary outcome is the relative risk to receive any FFP perioperatively. The inclusion of 110 patients per group will yield more than 80% power to detect a clinically relevant relative risk of 0.60 to receive FFP of

  7. Pointing control for LDR

    NASA Technical Reports Server (NTRS)

    Yam, Y.; Briggs, C.

    1988-01-01

    One important aspect of the LDR control problem is the possible excitations of structural modes due to random disturbances, mirror chopping, and slewing maneuvers. An analysis was performed to yield a first order estimate of the effects of such dynamic excitations. The analysis involved a study of slewing jitters, chopping jitters, disturbance responses, and pointing errors, making use of a simplified planar LDR model which describes the LDR dynamics on a plane perpendicular to the primary reflector. Briefly, the results indicate that the command slewing profile plays an important role in minimizing the resultant jitter, even to a level acceptable without any control action. An optimal profile should therefore be studied.

  8. Wavefront sensing, control, and pointing

    NASA Astrophysics Data System (ADS)

    Pitts, Thomas; Sevaston, George; Agronin, Michael; Bely, Pierre; Colavita, Mark; Clampin, Mark; Harvey, James; Idell, Paul; Sandler, Dave; Ulmer, Melville

    1992-08-01

    A majority of future NASA astrophysics missions from orbiting interferometers to 16-m telescopes on the Moon have, as a common requirement, the need to bring light from a large entrance aperture to the focal plane in a way that preserves the spatial coherence properties of the starlight. Only by preserving the phase of the incoming wavefront, can many scientific observations be made, observations that range from measuring the red shift of quasi-stellar objects (QSO's) to detecting the IR emission of a planet in orbit around another star. New technologies for wavefront sensing, control, and pointing hold the key to advancing our observatories of the future from those already launched or currently under development. As the size of the optical system increases, either to increase the sensitivity or angular resolution of the instrument, traditional technologies for maintaining optical wavefront accuracy become prohibitively expensive or completely impractical. For space-based instruments, the low mass requirement and the large temperature excursions further challenge existing technologies. The Hubble Space Telescope (HST) is probably the last large space telescope to rely on passive means to keep its primary optics stable and the optical system aligned. One needs only look to the significant developments in wavefront sensing, control, and pointing that have occurred over the past several years to appreciate the potential of this technology for transforming the capability of future space observatories. Future developments in space-borne telescopes will be based in part on developments in ground-based systems. Telescopes with rigid primary mirrors much larger than 5 m in diameter are impractical because of gravity loading. New technologies are now being introduced, such as active optics, that address the scale problem and that allow very large telescopes to be built. One approach is a segmented design such as that being pioneered by the W.M. Keck telescope now under

  9. Wavefront sensing, control, and pointing

    NASA Technical Reports Server (NTRS)

    Pitts, Thomas; Sevaston, George; Agronin, Michael; Bely, Pierre; Colavita, Mark; Clampin, Mark; Harvey, James; Idell, Paul; Sandler, Dave; Ulmer, Melville

    1992-01-01

    A majority of future NASA astrophysics missions from orbiting interferometers to 16-m telescopes on the Moon have, as a common requirement, the need to bring light from a large entrance aperture to the focal plane in a way that preserves the spatial coherence properties of the starlight. Only by preserving the phase of the incoming wavefront, can many scientific observations be made, observations that range from measuring the red shift of quasi-stellar objects (QSO's) to detecting the IR emission of a planet in orbit around another star. New technologies for wavefront sensing, control, and pointing hold the key to advancing our observatories of the future from those already launched or currently under development. As the size of the optical system increases, either to increase the sensitivity or angular resolution of the instrument, traditional technologies for maintaining optical wavefront accuracy become prohibitively expensive or completely impractical. For space-based instruments, the low mass requirement and the large temperature excursions further challenge existing technologies. The Hubble Space Telescope (HST) is probably the last large space telescope to rely on passive means to keep its primary optics stable and the optical system aligned. One needs only look to the significant developments in wavefront sensing, control, and pointing that have occurred over the past several years to appreciate the potential of this technology for transforming the capability of future space observatories. Future developments in space-borne telescopes will be based in part on developments in ground-based systems. Telescopes with rigid primary mirrors much larger than 5 m in diameter are impractical because of gravity loading. New technologies are now being introduced, such as active optics, that address the scale problem and that allow very large telescopes to be built. One approach is a segmented design such as that being pioneered by the W.M. Keck telescope now under

  10. Large spacecraft pointing and shape control

    NASA Technical Reports Server (NTRS)

    Hale, Arthur L.

    1987-01-01

    The overall objective of this program was the development of control algorithms that allow the concurrent operation of slewing, pointing, vibration, and shape control subsystems. This objective is important for near-term space surveillance missions that require the rapid retargeting and precise pointing of large flexible satellites. The success of these missions requires the design and concurrent operation of the various interacting control subsystems. There were two phases conducted: phase 1 was mathematical model development, and phase 2 was control development. The program is detailed and major conclusions given.

  11. 47 CFR 80.41 - Control points and dispatch points.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Control points and dispatch points. 80.41... SERVICES STATIONS IN THE MARITIME SERVICES Applications and Licenses § 80.41 Control points and dispatch... dispatch points may be installed and used without obtaining any authorization from the Commission....

  12. 47 CFR 80.41 - Control points and dispatch points.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 5 2011-10-01 2011-10-01 false Control points and dispatch points. 80.41... SERVICES STATIONS IN THE MARITIME SERVICES Applications and Licenses § 80.41 Control points and dispatch... dispatch points may be installed and used without obtaining any authorization from the Commission....

  13. 47 CFR 80.41 - Control points and dispatch points.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 5 2013-10-01 2013-10-01 false Control points and dispatch points. 80.41... SERVICES STATIONS IN THE MARITIME SERVICES Applications and Licenses § 80.41 Control points and dispatch... dispatch points may be installed and used without obtaining any authorization from the Commission....

  14. 47 CFR 80.41 - Control points and dispatch points.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 5 2014-10-01 2014-10-01 false Control points and dispatch points. 80.41... SERVICES STATIONS IN THE MARITIME SERVICES Applications and Licenses § 80.41 Control points and dispatch... dispatch points may be installed and used without obtaining any authorization from the Commission....

  15. 47 CFR 80.41 - Control points and dispatch points.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 5 2012-10-01 2012-10-01 false Control points and dispatch points. 80.41... SERVICES STATIONS IN THE MARITIME SERVICES Applications and Licenses § 80.41 Control points and dispatch... dispatch points may be installed and used without obtaining any authorization from the Commission....

  16. 36 CFR 907.6 - Major decision points.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... decisionmaking process. For most Corporation projects there are three distinct stages in the decision making...) Implementation stage. (b) Environmental review will be integrated into the decision making process of the... 36 Parks, Forests, and Public Property 3 2011-07-01 2011-07-01 false Major decision points. 907.6...

  17. 36 CFR 907.6 - Major decision points.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... decisionmaking process. For most Corporation projects there are three distinct stages in the decision making...) Implementation stage. (b) Environmental review will be integrated into the decision making process of the... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Major decision points. 907.6...

  18. 36 CFR § 1010.5 - Major decision points.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... throughout the decision-making process. Most Trust projects have three distinct stages in the decision-making...) Implementation stage. (b) Environmental review will be integrated into the decision-making process of the Trust... 36 Parks, Forests, and Public Property 3 2013-07-01 2012-07-01 true Major decision points. § 1010...

  19. 36 CFR § 907.6 - Major decision points.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... decisionmaking process. For most Corporation projects there are three distinct stages in the decision making...) Implementation stage. (b) Environmental review will be integrated into the decision making process of the... 36 Parks, Forests, and Public Property 3 2013-07-01 2012-07-01 true Major decision points. § 907...

  20. 36 CFR 907.6 - Major decision points.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... decisionmaking process. For most Corporation projects there are three distinct stages in the decision making...) Implementation stage. (b) Environmental review will be integrated into the decision making process of the... 36 Parks, Forests, and Public Property 3 2012-07-01 2012-07-01 false Major decision points. 907.6...

  1. 36 CFR 1010.5 - Major decision points.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...-making process. Most Trust projects have three distinct stages in the decision-making process: (1... stage. (b) Environmental review will be integrated into the decision-making process of the Trust as... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Major decision points. 1010.5...

  2. 36 CFR 1010.5 - Major decision points.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...-making process. Most Trust projects have three distinct stages in the decision-making process: (1... stage. (b) Environmental review will be integrated into the decision-making process of the Trust as... 36 Parks, Forests, and Public Property 3 2011-07-01 2011-07-01 false Major decision points. 1010.5...

  3. 36 CFR 907.6 - Major decision points.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... decisionmaking process. For most Corporation projects there are three distinct stages in the decision making...) Implementation stage. (b) Environmental review will be integrated into the decision making process of the... 36 Parks, Forests, and Public Property 3 2014-07-01 2014-07-01 false Major decision points. 907.6...

  4. Control of precision pointing system

    NASA Astrophysics Data System (ADS)

    Gu, Zheng

    Distributed-parameter modeling of tube with moving mass using Magnetic Compressional Damping Treatment (MCDT) is developed. Hamilton's principle is utilized to develop the model and boundary condition of a tube with moving mass using MCDT. Based on the electromagnetic theory, the relation between the generated magnet force of the actuator (MCDT) and the control current is determined. A stable control strategy is developed to damp out the vibration of the tube with moving mass using MCDT system. The fundamental characteristics of an active and a passive version of the Magnetic Compressional Damping Treatment (MCDT) are investigated by the finite element method. The damping characteristics of tube/MCDT system are modeled by Golla-Hughes-McTavish (GHM) method in order to predict the tube response in the time domain. The numerical results are verified through experimentation using a cantilevered tube treated with MCDT at the free end. The tube vibration due to an internally moving load is controlled by the MCDT using a deflection feedback controller. Close agreement is obtained between theory and experiments. The effectiveness of the MCDT in attenuating structural vibration of the tube has also been clearly demonstrated in the time and frequency domains. The developed theoretical and experimental techniques present invaluable tools for designing and predicting the performance of precision pointing tubes different damping treatments when subjected to moving loads.

  5. Satellite Power System (SPS) antenna pointing control

    NASA Technical Reports Server (NTRS)

    1980-01-01

    Accuracy requirements for the SPS antenna pointing control consists of a mechanical pointing accuracy of three arc minutes and an electronic phased array pointing accuracy of three arc seconds. Results of this study, based on the factors considered in current analysis, show that the three arc minute overall pointing control accuracy can be achieved for the SPS in practice.

  6. A low cost LST pointing control system

    NASA Technical Reports Server (NTRS)

    Glaese, J. R.; Kennel, H. F.; Nurre, G. S.; Seltzer, S. M.; Shelton, H. L.

    1975-01-01

    Vigorous efforts to reduce costs, coupled with changes in LST guidelines, took place in the Fall of 1974. These events made a new design of the LST and its Pointing and Attitude Control System possible. The major design changes are summarized as: an annular Support Systems Module; removal of image motion compensation; reaction wheels instead of CMG's; a magnetic torquer system to also perform the emergency and backup functions, eliminating the previously required mass expulsion system. Preliminary analysis indicates the Low Cost LST concept can meet the newly defined requirements and results in a significantly reduced development cost.

  7. 47 CFR 22.325 - Control points.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false Control points. 22.325 Section 22.325... Operational and Technical Requirements Operational Requirements § 22.325 Control points. Each station in the Public Mobile Services must have at least one control point and a person on duty who is responsible...

  8. 47 CFR 22.325 - Control points.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 2 2013-10-01 2013-10-01 false Control points. 22.325 Section 22.325... Operational and Technical Requirements Operational Requirements § 22.325 Control points. Each station in the Public Mobile Services must have at least one control point and a person on duty who is responsible for...

  9. 47 CFR 22.325 - Control points.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 2 2011-10-01 2011-10-01 false Control points. 22.325 Section 22.325... Operational and Technical Requirements Operational Requirements § 22.325 Control points. Each station in the Public Mobile Services must have at least one control point and a person on duty who is responsible for...

  10. 47 CFR 22.325 - Control points.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 2 2014-10-01 2014-10-01 false Control points. 22.325 Section 22.325... Operational and Technical Requirements Operational Requirements § 22.325 Control points. Each station in the Public Mobile Services must have at least one control point and a person on duty who is responsible for...

  11. 47 CFR 22.325 - Control points.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 2 2012-10-01 2012-10-01 false Control points. 22.325 Section 22.325... Operational and Technical Requirements Operational Requirements § 22.325 Control points. Each station in the Public Mobile Services must have at least one control point and a person on duty who is responsible for...

  12. Pointing control for the International Comet Mission

    NASA Technical Reports Server (NTRS)

    Leblanc, D. R.; Schumacher, L. L.

    1980-01-01

    The design of the pointing control system for the proposed International Comet Mission, intended to fly by Comet Halley and rendezvous with Comet Tempel-2 is presented. Following a review of mission objectives and the spacecraft configuration, design constraints on the pointing control system controlling the two-axis gimballed scan platform supporting the science instruments are discussed in relation to the scientific requirements of the mission. The primary design options considered for the pointing control system design for the baseline spacecraft are summarized, and the design selected, which employs a target-referenced, inertially stabilized control system, is described in detail. The four basic modes of operation of the pointing control subsystem (target acquisition, inertial hold, target track and slew) are discussed as they relate to operations at Halley and Tempel-2. It is pointed that the pointing control system design represents a significant advance in the state of the art of pointing controls for planetary missions.

  13. Pointing control for the International Comet Mission

    NASA Technical Reports Server (NTRS)

    Leblanc, D. R.; Schumacher, L. L.

    1980-01-01

    The design of the pointing control system for the proposed International Comet Mission, intended to fly by Comet Halley and rendezvous with Comet Tempel-2 is presented. Following a review of mission objectives and the spacecraft configuration, design constraints on the pointing control system controlling the two-axis gimballed scan platform supporting the science instruments are discussed in relation to the scientific requirements of the mission. The primary design options considered for the pointing control system design for the baseline spacecraft are summarized, and the design selected, which employs a target-referenced, inertially stabilized control system, is described in detail. The four basic modes of operation of the pointing control subsystem (target acquisition, inertial hold, target track and slew) are discussed as they relate to operations at Halley and Tempel-2. It is pointed that the pointing control system design represents a significant advance in the state of the art of pointing controls for planetary missions.

  14. Hemorrhage Control for Major Traumatic Vascular Injuries

    DTIC Science & Technology

    2015-10-01

    AWARD NUMBER: W81XWH-14-1-0112 TITLE: Hemorrhage Control for Major Traumatic Vascular Injuries PRINCIPAL INVESTIGATOR: John B. Holcomb, M.D...shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number...TITLE AND SUBTITLE Hemorrhage Control for Major Traumatic Vascular Injuries 5a. CONTRACT NUMBER W81XWH-14-1-0112 5b. GRANT NUMBER 5c. PROGRAM

  15. Pointing Control of Mobile Antenna on Vehicle

    NASA Astrophysics Data System (ADS)

    Nagashio, Tomoyuki; Kida, Takashi

    This paper describes a pointing control of a mobile antenna mounted on a vehicle. For precise pointing, the antenna must be controlled to point to a target under the influence of continuous disturbances acting on the vehicle. For this purpose, we propose an optimal controller design method in a framework of the H∞ gain-scheduled controller synthesis. By this synthesis, the optimal controller is obtained by using parameter varying notch-filter in order to attenuate the various frequency disturbances. We apply this design method to an automobile model having a rotating antenna.

  16. 36 CFR 1010.5 - Major decision points.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Trust Area must be considered along with technical, financial, and other factors throughout the decision... earliest point at which meaningful analysis can be developed for the proposed action or project and...

  17. 36 CFR 1010.5 - Major decision points.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Trust Area must be considered along with technical, financial, and other factors throughout the decision... earliest point at which meaningful analysis can be developed for the proposed action or project and...

  18. 14 CFR 1216.304 - Major decision points.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... the National Environmental Policy Act of 1969. Major NASA activities, particularly R&D (or SFCDC) and.../definition phase; the development/construction phase; and the operation phase. (Other NASA activities have... determination as to whether an environmental impact statement is required must be made prior to the decision...

  19. Pressure Points: Preventing and Controlling Hypertension

    MedlinePlus

    Skip Navigation Bar Home Current Issue Past Issues Pressure Points: Preventing and Controlling Hypertension Past Issues / Summer ... turn Javascript on. May is National High Blood Pressure Education Month, a good time for many Americans ...

  20. Strike Point Control on EAST Using an Isoflux Control Method

    NASA Astrophysics Data System (ADS)

    Xing, Zhe; Xiao, Bingjia; Luo, Zhengping; L. Walker, M.; A. Humphreys, D.

    2015-09-01

    For the advanced tokamak, the particle deposition and thermal load on the divertor is a big challenge. By moving the strike points on divertor target plates, the position of particle deposition and thermal load can be shifted. We could adjust the Poloidal Field (PF) coil current to achieve the strike point position feedback control. Using isoflux control method, the strike point position can be controlled by controlling the X point position. On the basis of experimental data, we establish relational expressions between X point position and strike point position. Benchmark experiments are carried out to validate the correctness and robustness of the control methods. The strike point position is successfully controlled following our command in the EAST operation. supported by the National Magnetic Confinement Fusion Science Program of China (Nos. 2012GB105000 and 2014GB103000)

  1. End-Point Control of Flexible Robots

    DTIC Science & Technology

    1984-10-01

    hierarchical force control system for the hand, *ith three levels, hand level coupling three fingers, finger level coupling four tendons , and tendon tension...level. Finger level and tendon tension control were implemented and demonstrated. During’ .the second ye-, an analysis was made of rolling objects...instrumented to sense tendon tensions and to compensate for friction. Friction is a major obstacle in controllability. The hand was designed for fine motion

  2. Optimal control problems with switching points

    NASA Astrophysics Data System (ADS)

    Seywald, Hans

    1991-09-01

    An overview is presented of the problems and difficulties that arise in solving optimal control problems with switching points. A brief discussion of existing optimality conditions is given and a numerical approach for solving the multipoint boundary value problems associated with the first-order necessary conditions of optimal control is presented. Two real-life aerospace optimization problems are treated explicitly. These are altitude maximization for a sounding rocket (Goddard Problem) in the presence of a dynamic pressure limit, and range maximization for a supersonic aircraft flying in the vertical, also in the presence of a dynamic pressure limit. In the second problem singular control appears along arcs with active dynamic pressure limit, which in the context of optimal control, represents a first-order state inequality constraint. An extension of the Generalized Legendre-Clebsch Condition to the case of singular control along state/control constrained arcs is presented and is applied to the aircraft range maximization problem stated above. A contribution to the field of Jacobi Necessary Conditions is made by giving a new proof for the non-optimality of conjugate paths in the Accessory Minimum Problem. Because of its simple and explicit character, the new proof may provide the basis for an extension of Jacobi's Necessary Condition to the case of the trajectories with interior point constraints. Finally, the result that touch points cannot occur for first-order state inequality constraints is extended to the case of vector valued control functions.

  3. Three loop balanced bridge feedback pointing control

    NASA Technical Reports Server (NTRS)

    Lurie, Boris J.

    1988-01-01

    The balanced bridge feedback (BBF) technique developed in communication engineering is applied to the multiloop pointing control problem. Using colocated sensors, BBF decouples the motor loop from the mechanical plant and increases the feedback bandwidth in the motor and plant loops.

  4. Three loop balanced bridge feedback pointing control

    NASA Technical Reports Server (NTRS)

    Lurie, Boris J.

    1988-01-01

    The balanced bridge feedback (BBF) technique developed in communication engineering is applied to the multiloop pointing control problem. Using colocated sensors, BBF decouples the motor loop from the mechanical plant and increases the feedback bandwidth in the motor and plant loops.

  5. Space Telescope precision pointing control system

    NASA Technical Reports Server (NTRS)

    Beals, G. A.; Crum, R. C.; Dougherty, H. J.; Hegel, D. K.; Kelley, J. L.

    1986-01-01

    The Hubble Space Telescope has the most stringent pointing requirements imposed on any spacecraft to date. The overall HST stability shall not exceed 0.007 arc-seconds rms. The Pointing Control System utilizes fine guidance sensors and rate gyros for attitude reference and rate information. Control torques are provided by reaction wheels. A digital computer collects the sensor data, performs the control law computations, and sends torque commands to the reaction wheels. To attain this precision pointing, improvements were made to the rate gyros to lower their noise characteristics and to the reaction wheels to reduce their emitted vibration levels. The control system design was validated in a test sequence which progressed from model verification tests on an air-bearing to operations-oriented, closed loop testing on the assembled vehicle. A test system is described which allowed the simultaneous production of test case command loads for the flight computer and plots of predicted profiles to assist in test data analysis. Workarounds were required during system test to accommodate gyro biases and noise introduced into the closed loop system. Testing and analysis indicate that the HST will provide the capability to meet the requirements for precision pointing.

  6. Multiferroics: Making a point of control

    NASA Astrophysics Data System (ADS)

    Kalinin, Sergei V.

    2017-02-01

    The coexistence of spin order and disorder at a critical point in the phase diagram of multiferroic materials may be exploited to locally control magnetoelectric coupling -- as is now shown for doped BiFeO3 by means of scanning probe microscopy.

  7. Parachute suspended solar pointing control system

    NASA Astrophysics Data System (ADS)

    Sakoda, G. T.; Fujimoto, R. J.; Shigemoto, J. M.; Windsor, R. M.

    A high altitude parachute suspended solar pointing control system has been developed and flight tested for use in the altitude range of 30 to 70 kilometers. This development provides an opportunity for extended solar observations at altitudes higher than that attainable by helium balloons. The new system utilizes the NASA high altitude cross parachute to slow the descent of a rocket launched payload allowing observations in the region of interest. Solar pointing is established by using solar sensors in conjunction with a servo controlled platform and cold gas thrusters for payload roll control. The inherent spin of the cross parachute is decoupled by a swivel joint attached to the parachute suspension lines. This paper describes the design, test and flight performance of the new system.

  8. Parachute-suspended solar pointing control system

    NASA Astrophysics Data System (ADS)

    Sakoda, G. T.; Fujimoto, R. J.; Shigemoto, J. M.; Windsor, R. M.

    1984-04-01

    A high altitude parachute suspended solar pointing control system has been developed and flight tested for use in the altitude range of 30 to 70 kilometers. This development provides an opportunity for extended solar observations at altitudes higher than that attainable by helium balloons. The new system utilizes the NASA high altitude cross parachute to slow the descent of a rocket launched payload allowing observations in the region of interest. Solar pointing is established by using solar sensors in conjunction with a servo controlled platform and cold gas thrusters for payload roll control. The inherent spin of the cross parachute is decoupled by a swivel joint attached to the parachute suspension lines. This paper describes the design, test and flight performance of the new system.

  9. Remote temperature-set-point controller

    DOEpatents

    Burke, William F.; Winiecki, Alan L.

    1986-01-01

    An instrument for carrying out mechanical strain tests on metallic samples with the addition of an electrical system for varying the temperature with strain, the instrument including opposing arms and associated equipment for holding a sample and varying the mechanical strain on the sample through a plurality of cycles of increasing and decreasing strain within predetermined limits, circuitry for producing an output signal representative of the strain during the tests, apparatus including a set point and a coil about the sample for providing a controlled temperature in the sample, and circuitry interconnected between the strain output signal and set point for varying the temperature of the sample linearly with strain during the tests.

  10. Controlling superconductivity by tunable quantum critical points.

    PubMed

    Seo, S; Park, E; Bauer, E D; Ronning, F; Kim, J N; Shim, J-H; Thompson, J D; Park, Tuson

    2015-03-04

    The heavy fermion compound CeRhIn5 is a rare example where a quantum critical point, hidden by a dome of superconductivity, has been explicitly revealed and found to have a local nature. The lack of additional examples of local types of quantum critical points associated with superconductivity, however, has made it difficult to unravel the role of quantum fluctuations in forming Cooper pairs. Here, we show the precise control of superconductivity by tunable quantum critical points in CeRhIn5. Slight tin-substitution for indium in CeRhIn5 shifts its antiferromagnetic quantum critical point from 2.3 GPa to 1.3 GPa and induces a residual impurity scattering 300 times larger than that of pure CeRhIn5, which should be sufficient to preclude superconductivity. Nevertheless, superconductivity occurs at the quantum critical point of the tin-doped metal. These results underline that fluctuations from the antiferromagnetic quantum criticality promote unconventional superconductivity in CeRhIn5.

  11. Digital controller design: Analysis of the annular suspension pointing system

    NASA Technical Reports Server (NTRS)

    Kuo, B. C.

    1979-01-01

    The Annular Suspension and Pointing System (ASPS) is a payload auxiliary pointing device of the Space Shuttle. The ASPS is comprised of two major subassemblies, a vernier and a coarse pointing subsystem. The experiment is attached to a mounting plate/rim combination which is suspended on magnetic bearing/actuators (MBA) strategically located about the rim. Fine pointing is achieved by gimballing the plate/rim within the MBA gaps. Control about the experiment line-of-sight is obtained through the use of a non-contacting rim drive and positioning torquer. All sensors used to close the servo loops on the vernier system are noncontacting elements. Therefore, the experiment is a free-flyer constrained only by the magnetic forces generated by the control loops.

  12. Remote temperature-set-point controller

    DOEpatents

    Burke, W.F.; Winiecki, A.L.

    1984-10-17

    An instrument is described for carrying out mechanical strain tests on metallic samples with the addition of means for varying the temperature with strain. The instrument includes opposing arms and associated equipment for holding a sample and varying the mechanical strain on the sample through a plurality of cycles of increasing and decreasing strain within predetermined limits, circuitry for producing an output signal representative of the strain during the tests, apparatus including a a set point and a coil about the sample for providing a controlled temperature in the sample, and circuitry interconnected between the strain output signal and set point for varying the temperature of the sample linearly with strain during the tests.

  13. Catfish Point Control Structure: Foundation Investigation

    DTIC Science & Technology

    1948-01-01

    Averaf£e 63-88 75 20-27 23 43-62 51 SamJ1le Depth Elev !!!?.:.. Ft ~ Borins 1 - Gr.El. i 2.8 7 6.8- 7.8 -4.5 10 10.0-10.9 -7.6 13 13.1-13.9...I LEGEND @ ’ UNDISTURBED SAMPLE BORIN (; • GENERAL SAMPLE BORING .· A- 2 • - Grand Lake WATERWAYS EXPERIMENT SiAT’ON CATFISH POINT CONTROL

  14. 47 CFR 90.429 - Control point and dispatch point requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 5 2013-10-01 2013-10-01 false Control point and dispatch point requirements... and dispatch point requirements. (a) Control point required. Unless permitted to be operated on an... operation of the transmitter either to disconnect the dispatch point circuits from the transmitter or...

  15. 47 CFR 90.429 - Control point and dispatch point requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 5 2014-10-01 2014-10-01 false Control point and dispatch point requirements... and dispatch point requirements. (a) Control point required. Unless permitted to be operated on an... operation of the transmitter either to disconnect the dispatch point circuits from the transmitter or...

  16. 47 CFR 90.429 - Control point and dispatch point requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 5 2011-10-01 2011-10-01 false Control point and dispatch point requirements... and dispatch point requirements. (a) Control point required. Unless permitted to be operated on an... operation of the transmitter either to disconnect the dispatch point circuits from the transmitter or...

  17. 47 CFR 90.429 - Control point and dispatch point requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 5 2012-10-01 2012-10-01 false Control point and dispatch point requirements... and dispatch point requirements. (a) Control point required. Unless permitted to be operated on an... operation of the transmitter either to disconnect the dispatch point circuits from the transmitter or...

  18. 47 CFR 90.429 - Control point and dispatch point requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Control point and dispatch point requirements... and dispatch point requirements. (a) Control point required. Unless permitted to be operated on an... operation of the transmitter either to disconnect the dispatch point circuits from the transmitter or...

  19. 49 CFR 236.403 - Signals at controlled point.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., INSPECTION, MAINTENANCE, AND REPAIR OF SIGNAL AND TRAIN CONTROL SYSTEMS, DEVICES, AND APPLIANCES Traffic Control Systems Standards § 236.403 Signals at controlled point. Signals at controlled point shall be...

  20. 49 CFR 236.403 - Signals at controlled point.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ..., INSPECTION, MAINTENANCE, AND REPAIR OF SIGNAL AND TRAIN CONTROL SYSTEMS, DEVICES, AND APPLIANCES Traffic Control Systems Standards § 236.403 Signals at controlled point. Signals at controlled point shall be...

  1. Do Nondomestic Undergraduates Choose a Major Field in Order to Maximize Grade Point Averages?

    ERIC Educational Resources Information Center

    Bergman, Matthew E.; Fass-Holmes, Barry

    2016-01-01

    The authors investigated whether undergraduates attending an American West Coast public university who were not U.S. citizens (nondomestic) maximized their grade point averages (GPA) through their choice of major field. Multiple regression hierarchical linear modeling analyses showed that major field's effect size was small for these…

  2. 49 CFR 236.403 - Signals at controlled point.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 4 2013-10-01 2013-10-01 false Signals at controlled point. 236.403 Section 236..., INSPECTION, MAINTENANCE, AND REPAIR OF SIGNAL AND TRAIN CONTROL SYSTEMS, DEVICES, AND APPLIANCES Traffic Control Systems Standards § 236.403 Signals at controlled point. Signals at controlled point shall be so...

  3. 49 CFR 236.403 - Signals at controlled point.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Signals at controlled point. 236.403 Section 236..., INSPECTION, MAINTENANCE, AND REPAIR OF SIGNAL AND TRAIN CONTROL SYSTEMS, DEVICES, AND APPLIANCES Traffic Control Systems Standards § 236.403 Signals at controlled point. Signals at controlled point shall be so...

  4. Hemorrhage Control for Major Traumatic Vascular Injuries

    DTIC Science & Technology

    2016-10-01

    hypothesis is that minimally invasive, device-driven and expert-led NCTH control techniques improve survival compared to traditional open vascular surgery...observational study to test the hypothesis that less-invasive device-driven and expert-led hemorrhage control techniques are associated with...invasive, device- driven and expert-led NCTH control techniques improve survival compared to traditional open vascular surgery. In addition to UTHealth

  5. 47 CFR 11.16 - National Control Point Procedures.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false National Control Point Procedures. 11.16 Section 11.16 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL EMERGENCY ALERT SYSTEM (EAS) General § 11.16 National Control Point Procedures. The National Control Point Procedures are written...

  6. 49 CFR 236.404 - Signals at adjacent control points.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ..., INSPECTION, MAINTENANCE, AND REPAIR OF SIGNAL AND TRAIN CONTROL SYSTEMS, DEVICES, AND APPLIANCES Traffic Control Systems Standards § 236.404 Signals at adjacent control points. Signals at adjacent controlled... 49 Transportation 4 2011-10-01 2011-10-01 false Signals at adjacent control points....

  7. 49 CFR 236.404 - Signals at adjacent control points.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., INSPECTION, MAINTENANCE, AND REPAIR OF SIGNAL AND TRAIN CONTROL SYSTEMS, DEVICES, AND APPLIANCES Traffic Control Systems Standards § 236.404 Signals at adjacent control points. Signals at adjacent controlled... 49 Transportation 4 2010-10-01 2010-10-01 false Signals at adjacent control points....

  8. Major tanker spill off Spain under control

    SciTech Connect

    Not Available

    1992-12-14

    This paper reports that a 23 sq mile oil slick along Spain's northwest coast, spreading form the wreckage of the Greek oil tanker Aegean Sea, was for the most part under control as of Dec. 10, Spanish authorities reported. Various press reports put the total spill volume at 490,000 bbl, about double that leaked by the Exxon Valdez supertanker off Alaska in 1989. If initial reports of the spill volume are borne out, the Aegean Sea spill would rank at least as one of the 10 biggest tanker spills.

  9. Polio control after certification: major issues outstanding.

    PubMed Central

    Fine, Paul E. M.; Oblapenko, George; Sutter, Roland W.

    2004-01-01

    Now that the global eradication of wild poliovirus is almost within sight, planning for the post-certification era is becoming a priority issue. It is agreed that a stockpile of appropriate polio vaccines will need to be established, and a surveillance and response capacity will need to be maintained, in order to protect the world against any possible future outbreaks attributable either to the persistence of wild poliovirus or vaccine-derived polioviruses (VDPVs) or to the unintentional or intentional release of poliovirus from a laboratory or vaccine store. Although it has been suggested that the stockpile should consist of monovalent oral poliovirus vaccine (mOPV), many questions remain concerning its nature, financing, management, and use--in particular, because of uncertainties over future national vaccination policies, and over the availability of different vaccines, after the certification of wild poliovirus eradication. There are further uncertainties concerning the possible role and efficacy of inactivated poliovirus vaccine (IPV) used either routinely or in outbreak control in low-hygiene settings, the potential for rapid geographical spread of polioviruses should an outbreak occur after certification, and the risks inherent in introducing additional oral polio vaccine (OPV) viruses into populations in which the vaccine coverage and prevalence of immunity have declined, and which may thus favour the spread of VDPVs. Given these important gaps in knowledge, no country should discontinue polio vaccination until a coordinated policy for the post-certification era has been developed and the recommended measures have been put in place. PMID:15106300

  10. 47 CFR 90.463 - Transmitter control points.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    .... (b) Each station or licensed system of communication shall normally have a control point, or control.... Provided, however, Control point requirements may vary from one system to another, depending upon the... fixed position in a system of communication at or from which the control operator exercises supervision...

  11. 47 CFR 90.463 - Transmitter control points.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    .... (b) Each station or licensed system of communication shall normally have a control point, or control.... Provided, however, Control point requirements may vary from one system to another, depending upon the... fixed position in a system of communication at or from which the control operator exercises supervision...

  12. End-Point Control of Flexible Manipulators.

    DTIC Science & Technology

    1986-09-01

    axis), and motor tachometer outputs. The motor controller includes three separate analog inputs to each motor , current limiters, and motor disabling...PAGE Block 19 Continued An experimental system was built around a dextrous three -finger hand, sensors, computer interfaces, and control system. The hand... three finger hand with sensors, on sensory control of the hand, on intelligent task execution with the hand, and on sensor technol- ogy. ARL describes

  13. MSFC Skylab attitude and pointing control system mission evaluation

    NASA Technical Reports Server (NTRS)

    Chubb, W. B.

    1974-01-01

    The results of detailed performance analyses of the attitude and pointing control system in-orbit hardware and software on Skylab are reported. Performance is compared with requirements, test results, and prelaunch predictions. A brief history of the altitude and pointing control system evolution leading to the launch configuration is presented. The report states that the attitude and pointing system satisfied all requirements.

  14. Pointing control design for autonomous space vehicle applications

    SciTech Connect

    Young, K.D.

    1993-03-01

    This paper addresses the design of pointing control systems for autonomous space vehicles. The function of the pointing control system is to keep distant orbiting objects within the field-of-view of an on-board optical sensor. We outline the development of novel nonlinear control algorithms which exploit the availability of on- board sensors. Simulation results comparing the performance of the different pointing control implementations are presented.

  15. Validation of acid washes as critical control points in hazard analysis and critical control point systems.

    PubMed

    Dormedy, E S; Brashears, M M; Cutter, C N; Burson, D E

    2000-12-01

    A 2% lactic acid wash used in a large meat-processing facility was validated as an effective critical control point (CCP) in a hazard analysis and critical control point (HACCP) plan. We examined the microbial profiles of beef carcasses before the acid wash, beef carcasses immediately after the acid wash, beef carcasses 24 h after the acid wash, beef subprimal cuts from the acid-washed carcasses, and on ground beef made from acid-washed carcasses. Total mesophilic, psychrotrophic, coliforms, generic Escherichia coli, lactic acid bacteria, pseudomonads, and acid-tolerant microorganisms were enumerated on all samples. The presence of Salmonella spp. was also determined. Acid washing significantly reduced all counts except for pseudomonads that were present at very low numbers before acid washing. All other counts continued to stay significantly lower (P < 0.05) than those on pre-acid-washed carcasses throughout all processing steps. Total bacteria, coliforms, and generic E. coli enumerated on ground beef samples were more than 1 log cycle lower than those reported in the U.S. Department of Agriculture Baseline data. This study suggests that acid washes may be effective CCPs in HACCP plans and can significantly reduce the total number of microorganisms present on the carcass and during further processing.

  16. Dorsal scapular nerve injury after trigger point injection into the rhomboid major muscle: A case report.

    PubMed

    Lee, Dong Gyu; Chang, Min Cheol

    2017-08-14

    We report the case of a patient who presented with right dorsal scapular neuropathy after a trigger point injection into the right rhomboid major muscle. Through a nerve conduction study and electromyography, we demonstrated dorsal scapular nerve injury in this patient. A 38-year-old man complained that his right shoulder functioned less optimally during push-up exercises after a trigger point injection 4 weeks prior. Physical examination revealed mildly reduced right shoulder retractor muscle strength compared with the left side. We performed a nerve conduction velocity test and electromyography 5 weeks after the injection. The compound muscle action potential of the right dorsal scapular nerve showed low amplitude (left vs. right side: 5.2 vs. 1.6 mV) and delayed latency (left vs. right side: 4.9 vs. 6.8 ms). Positive sharp wave (1+) and mildly reduced recruitment were seen on electromyography of the rhomboid major muscle. The findings of the nerve conduction velocity test and electromyography indicated partial right dorsal scapular neuropathy. The nerve injury seemed to have been caused by the needle inserted during trigger point injection. Clinicians should pay attention to the occurrence of dorsal scapular nerve injury when performing trigger point injection into the rhomboid muscle.

  17. Fine pointing control for free-space optical communication

    NASA Technical Reports Server (NTRS)

    Portillo, A. A.; Ortiz, G. G.; Racho, C.

    2000-01-01

    Free-Space Optical Communications requires precise, stable laser pointing to maintain operating conditions. This paper also describes the software and hardware implementation of Fine Pointing Control based on the Optical Communications Demonstrator architecture.

  18. Control points within the cell cycle

    SciTech Connect

    Van't Hof, J.

    1984-01-01

    Evidence of the temporal order of chromosomal DNA replication argues favorably for the view that the cell cycle is controlled by genes acting in sequence whose time of expression is determined by mitosis and the amount of nuclear DNA (2C vs 4C) in the cell. Gl and G2 appear to be carbohydrate dependent in that cells starved of either carbohydrate of phosphate fail to make these transitions. Cells deprived of nitrate, however, fail only at Gl to S transition indicating that the controls that operate in G1 differ from those that operate in G2. 46 references, 5 figures.

  19. Strike Point Control for the National Spherical Torus Experiment (NSTX)

    SciTech Connect

    Kolemen, E.; Gates, D. A.; Rowley, C. W.; Kasdin, N. J.; Kallman, J.; Gerhardt, S.; Soukhanovskii, V.; Mueller, D.

    2010-07-09

    This paper presents the first control algorithm for the inner and outer strike point position for a Spherical Torus (ST) fusion experiment and the performance analysis of the controller. A liquid lithium divertor (LLD) will be installed on NSTX which is believed to provide better pumping than lithium coatings on carbon PFCs. The shape of the plasma dictates the pumping rate of the lithium by channeling the plasma to LLD, where strike point location is the most important shape parameter. Simulations show that the density reduction depends on the proximity of strike point to LLD. Experiments were performed to study the dynamics of the strike point, design a new controller to change the location of the strike point to desired location and stabilize it. The most effective PF coils in changing inner and outer strike points were identified using equilibrium code. The PF coil inputs were changed in a step fashion between various set points and the step response of the strike point position was obtained. From the analysis of the step responses, PID controllers for the strike points were obtained and the controller was tuned experimentally for better performance. The strike controller was extended to include the outer-strike point on the inner plate to accommodate the desired low outer-strike points for the experiment with the aim of achieving "snowflake" divertor configuration in NSTX.

  20. Mass Measurements beyond the Major r-Process Waiting Point {sup 80}Zn

    SciTech Connect

    Baruah, S.; Herlert, A.; Schweikhard, L.; Audi, G.; Guenaut, C.; Lunney, D.; Blaum, K.; George, S.; Dworschak, M.; Herfurth, F.; Yazidjian, C.; Hager, U.; Kellerbauer, A.; Kluge, H.-J.; Schatz, H.

    2008-12-31

    High-precision mass measurements on neutron-rich zinc isotopes {sup 71m,72-81}Zn have been performed with the Penning trap mass spectrometer ISOLTRAP. For the first time, the mass of {sup 81}Zn has been experimentally determined. This makes {sup 80}Zn the first of the few major waiting points along the path of the astrophysical rapid neutron-capture process where neutron-separation energy and neutron-capture Q-value are determined experimentally. The astrophysical conditions required for this waiting point and its associated abundance signatures to occur in r-process models can now be mapped precisely. The measurements also confirm the robustness of the N=50 shell closure for Z=30.

  1. All sky pointing attitude control system

    NASA Technical Reports Server (NTRS)

    Lorell, K. R.; Murphy, J. P. (Inventor)

    1977-01-01

    In a strapped-down gyroscope space vehicle attitude control system, a method and apparatus are provided for gyro drift and input axis misalignment error compensation employing a sun and a star tracker and preselected vehicle calibration maneuvers. The outputs of two-axis strapped-down gyroscopes nominally aligned with the optical axis of the sun and star trackers are measured to provide gyro drift calibration, roll, pitch and yaw axis scale factors and values corresponding to the degree of nonorthogonality between the roll axis and the pitch and yaw gyro input axes and the nonorthogonality of the roll and pitch axes relative to the yaw axis. The vehicle is then rolled and yawed through precomputed angles as modified by the calibrated data stored in a digital computer, and acquires a target without recourse to external references.

  2. Generalizations of fuzzy linguistic control points in geometric design

    NASA Astrophysics Data System (ADS)

    Sallehuddin, M. H.; Wahab, A. F.; Gobithaasan, R. U.

    2014-07-01

    Control points are geometric primitives that play an important role in designing the geometry curve and surface. When these control points are blended with some basis functions, there are several geometric models such as Bezier, B-spline and NURBS(Non-Uniform Rational B-Spline) will be produced. If the control points are defined by the theory of fuzzy sets, then fuzzy geometric models are produced. But the fuzzy geometric models can only solve the problem of uncertainty complex. This paper proposes a new definition of fuzzy control points with linguistic terms. When the fuzzy control points with linguistic terms are blended with basis functions, then a fuzzy linguistic geometric model is produced. This paper ends with some numerical examples illustrating linguistic control attributes of fuzzy geometric models.

  3. Reconfigurable Pointing Control for High Resolution Space Spectroscopy

    NASA Technical Reports Server (NTRS)

    Bayard, David S.; Kia, Tooraj; Van Cleve, Jeffrey

    1997-01-01

    In this paper, a pointing control performance criteria is established to suppport high resolution space spectroscopy. Results indicate that these pointing control requirements are very stringent, and would typically be difficult to meet using standard 3-axis spacecraft control. To resolve this difficulty, it is shown that performance can be significantly improved using a reconfigurable control architecture that switches among a small bankof detuned Kalman filters. The effectiveness of the control reconfiguration approach is demonstrated by example on the Space Infra-Red Telescope Facility (SIRTF) pointing system, in support of the InfraRed Spectrograph (IRS) payload.

  4. Point-to-Point Ultra-Remote Asymmetric Control with Flexible Linker.

    PubMed

    Kawasaki, Tsuneomi; Ishikawa, Yasuyuki; Minato, Yoshihiro; Otsuka, Takashi; Yonekubo, Shigeru; Sato, Itaru; Shibata, Takanori; Matsumoto, Arimasa; Soai, Kenso

    2017-01-05

    An ultra-remote intramolecular (point-to-point) asymmetric control through 38 bonds (1,39-asymmetric induction) has been achieved by using the principle of direct supramolecular orientation of catalytic and reactive moieties in asymmetric autocatalysis. We found the highly stereoselective diisopropylzinc addition reaction using designed molecules possessing pyrimidine sites at each terminal of a conformationally flexible simple methylene chain.

  5. Reconfigurable Pointing Control for High Resolution Space Spectroscopy

    NASA Technical Reports Server (NTRS)

    Bayard, David S.; Kia, Tooraj; vanCleve, Jeffrey

    1997-01-01

    In this paper, a pointing control performance criteria is established to support high resolution space spectroscopy. Results indicate that these pointing requirements are very stringent, and would typically be difficult to meet using standard 3-axis spacecraft control. To resolve this difficulty, it is shown that performance can be significantly improved using a reconfigurable control architecture that switches among a small bank of detuned Kalman filters. The effectiveness of the control reconfiguration approach is demonstrated by example on the Space Infra, Red Telescope Facility (SIRTF) pointing system, in support of the Infrared Spectrograph (IRS) payload.

  6. Onboard utilization of ground control points for image correction. Volume 3: Ground control point simulation software design

    NASA Technical Reports Server (NTRS)

    1981-01-01

    The software developed to simulate the ground control point navigation system is described. The Ground Control Point Simulation Program (GCPSIM) is designed as an analysis tool to predict the performance of the navigation system. The system consists of two star trackers, a global positioning system receiver, a gyro package, and a landmark tracker.

  7. Shuttle infrared telescope facility pointing and control system

    NASA Technical Reports Server (NTRS)

    Lorell, K. R.; Barrows, W. F.; Matsumoto, Y. T.

    1981-01-01

    The Shuttle Infrared Telescope Facility (SIRTF) is being designed as a 0.85 m cryogenically cooled telescope capable of a three order of magnitude improvement over currently available infrared instruments. The SIRTF requires that the image at the focal plane be stabilized to better than 0.25 arcsec with an absolute accuracy of 1.0 arcsec. Current pointing-mount performance simulations indicate that neither of these requirements can be met without additional stabilization. The SIRTF pointing and control system will utilize gyro outputs, star field position measurements from a focal plane fine guidance sensor, and a steerable secondary mirror to provide the necessary stabilization and pointing control. The charge coupled device fine guidance sensor tracks multiple stars simultaneously and, through the use of multistar processing algorithms in a high performance microcomputer, generates three-axis attitude errors and gyro-drift estimates to correct the pointing-mount gyros. A high-bandwidth feedforward loop, driven directly from the pointing-mount gyro package, controls the steering mirror in order to correct disturbances not compensated for by the pointing-mount control system. A prototype design for the SIRTF pointing and control system is described in detail. Performance analyses made using a digital simulation of the pointing and control system as well as experimental data obtained in laboratory and field test measurements are presented.

  8. A multiple pointing-mount control strategy for space platforms

    NASA Technical Reports Server (NTRS)

    Johnson, C. D.

    1992-01-01

    A new disturbance-adaptive control strategy for multiple pointing-mount space platforms is proposed and illustrated by consideration of a simplified 3-link dynamic model of a multiple pointing-mount space platform. Simulation results demonstrate the effectiveness of the new platform control strategy. The simulation results also reveal a system 'destabilization phenomena' that can occur if the set of individual platform-mounted experiment controllers are 'too responsive.'

  9. Octopuses use a human-like strategy to control precise point-to-point arm movements.

    PubMed

    Sumbre, Germán; Fiorito, Graziano; Flash, Tamar; Hochner, Binyamin

    2006-04-18

    One of the key problems in motor control is mastering or reducing the number of degrees of freedom (DOFs) through coordination. This problem is especially prominent with hyper-redundant limbs such as the extremely flexible arm of the octopus. Several strategies for simplifying these control problems have been suggested for human point-to-point arm movements. Despite the evolutionary gap and morphological differences, humans and octopuses evolved similar strategies when fetching food to the mouth. To achieve this precise point-to-point-task, octopus arms generate a quasi-articulated structure based on three dynamic joints. A rotational movement around these joints brings the object to the mouth . Here, we describe a peripheral neural mechanism-two waves of muscle activation propagate toward each other, and their collision point sets the medial-joint location. This is a remarkably simple mechanism for adjusting the length of the segments according to where the object is grasped. Furthermore, similar to certain human arm movements, kinematic invariants were observed at the joint level rather than at the end-effector level, suggesting intrinsic control coordination. The evolutionary convergence to similar geometrical and kinematic features suggests that a kinematically constrained articulated limb controlled at the level of joint space is the optimal solution for precise point-to-point movements.

  10. Nonpoint and Point Sources of Nitrogen in Major Watersheds of the United States

    USGS Publications Warehouse

    Puckett, Larry J.

    1994-01-01

    Estimates of nonpoint and point sources of nitrogen were made for 107 watersheds located in the U.S. Geological Survey's National Water-Quality Assessment Program study units throughout the conterminous United States. The proportions of nitrogen originating from fertilizer, manure, atmospheric deposition, sewage, and industrial sources were found to vary with climate, hydrologic conditions, land use, population, and physiography. Fertilizer sources of nitrogen are proportionally greater in agricultural areas of the West and the Midwest than in other parts of the Nation. Animal manure contributes large proportions of nitrogen in the South and parts of the Northeast. Atmospheric deposition of nitrogen is generally greatest in areas of greatest precipitation, such as the Northeast. Point sources (sewage and industrial) generally are predominant in watersheds near cities, where they may account for large proportions of the nitrogen in streams. The transport of nitrogen in streams increases as amounts of precipitation and runoff increase and is greatest in the Northeastern United States. Because no single nonpoint nitrogen source is dominant everywhere, approaches to control nitrogen must vary throughout the Nation. Watershed-based approaches to understanding nonpoint and point sources of contamination, as used by the National Water-Quality Assessment Program, will aid water-quality and environmental managers to devise methods to reduce nitrogen pollution.

  11. Laying medicine open: understanding major turning points in the history of medical ethics.

    PubMed

    McCullough, Laurence B

    1999-03-01

    At different times during its history medicine has been laid open to accountability for its scientific and moral quality. This phenonmenon of laying medicine open has sometimes resulted in major turning points in the history of medical ethics. In this paper, I examine two examples of when the laying open of medicine has generated such turning points: eighteenth-century British medicine and late twentieth-century American medicine. In the eighteenth century, the Scottish physician-philosopher, John Gregory (1724-1773), concerned with the unscientific, entrepreneurial, self-interested nature of then current medical practice, laid medicine open to accountability using the tools of ethics and philosophy of medicine. In the process, Gregory wrote the first professional ethics of medicine in the English-language literature, based on the physician's fiduciary responsibility to the patient. In the late twentieth century, the managed practice of medicine has laid medicine open to accountability for its scientific quality and economic cost. This current laying open of medicine creates the challenge of developing medical ethics and bioethics for population-based medical science and practice.

  12. Digital controller design: Analysis of the annular suspension pointing system

    NASA Technical Reports Server (NTRS)

    1977-01-01

    The annular suspension and pointing system (ASPS) a payload auxiliary pointing device of the space shuttle is briefly described along with the function of the digital controller. The equations of motion of a simplified plan planar model of the ASPS are derived. Results of computer simulations are discussed.

  13. Appropriate depth of needle insertion during rhomboid major trigger point block.

    PubMed

    Seol, Seung Jun; Cho, Hyungpil; Yoon, Do Hyun; Jang, Seong Ho

    2014-02-01

    To investigate an appropriate depth of needle insertion during trigger point injection into the rhomboid major muscle. Sixty-two patients who visited our department with shoulder or upper back pain participated in this study. The distance between the skin and the rhomboid major muscle (SM) and the distance between the skin and rib (SB) were measured using ultrasonography. The subjects were divided into 3 groups according to BMI: BMI less than 23 kg/m(2) (underweight or normal group); 23 kg/m(2) or more to less than 25 kg/m(2) (overweight group); and 25 kg/m(2) or more (obese group). The mean±standard deviation (SD) of SM and SB of each group were calculated. A range between mean+1 SD of SM and the mean-1 SD of SB was defined as a safe margin. The underweight or normal group's SM, SB, and the safe margin were 1.2±0.2, 2.1±0.4, and 1.4 to 1.7 cm, respectively. The overweight group's SM and SB were 1.4±0.2 and 2.4±0.9 cm, respectively. The safe margin could not be calculated for this group. The obese group's SM, SB, and the safe margin were 1.8±0.3, 2.7±0.5, and 2.1 to 2.2 cm, respectively. This study will help us to set the standard depth of safe needle insertion into the rhomboid major muscle in an effective manner without causing any complications.

  14. Appropriate Depth of Needle Insertion During Rhomboid Major Trigger Point Block

    PubMed Central

    Seol, Seung Jun; Cho, Hyungpil; Yoon, Do Hyun

    2014-01-01

    Objective To investigate an appropriate depth of needle insertion during trigger point injection into the rhomboid major muscle. Methods Sixty-two patients who visited our department with shoulder or upper back pain participated in this study. The distance between the skin and the rhomboid major muscle (SM) and the distance between the skin and rib (SB) were measured using ultrasonography. The subjects were divided into 3 groups according to BMI: BMI less than 23 kg/m2 (underweight or normal group); 23 kg/m2 or more to less than 25 kg/m2 (overweight group); and 25 kg/m2 or more (obese group). The mean±standard deviation (SD) of SM and SB of each group were calculated. A range between mean+1 SD of SM and the mean-1 SD of SB was defined as a safe margin. Results The underweight or normal group's SM, SB, and the safe margin were 1.2±0.2, 2.1±0.4, and 1.4 to 1.7 cm, respectively. The overweight group's SM and SB were 1.4±0.2 and 2.4±0.9 cm, respectively. The safe margin could not be calculated for this group. The obese group's SM, SB, and the safe margin were 1.8±0.3, 2.7±0.5, and 2.1 to 2.2 cm, respectively. Conclusion This study will help us to set the standard depth of safe needle insertion into the rhomboid major muscle in an effective manner without causing any complications. PMID:24639929

  15. Conceptual design of pointing control systems for space station gimballed payloads

    NASA Technical Reports Server (NTRS)

    Hughes, Robert O.

    1986-01-01

    A conceptual design of the control system for Payload Pointing Systems (PPS) is developed using classic Proportional-Integral-Derivatives (PID) techniques. The major source of system pointing error is due to the disturbance-rich environment of the space station in the form of gimbal baseplate motions. These baseplate vibrations are characterized using Fast Fourier Transform (FFT) techniques. Both time domain and frequency domain dynamic models are developed to assess control system performance. Three basic methods exist for the improvement of PPS pointing performance: increase control system bandwidth, add Image Motion Compensation, and/or reduce (or change) the baseplate disturbance environment.

  16. Implementation of hazard analysis critical control point in jameed production.

    PubMed

    Al-Saed, A K; Al-Groum, R M; Al-Dabbas, M M

    2012-06-01

    The average of standard plate count and coliforms, Staphylococcus aureus and Salmonella counts for three home-made jameed samples, a traditional fermented dairy product, before applying hazard analysis critical control point system were 2.1 × 10(3), 8.9 × 10(1), 4 × 10(1) and less than 10 cfu/g, respectively. The developed hazard analysis critical control point plan resulted in identifying ten critical control points in the flow chart of jameed production. The critical control points included fresh milk receiving, pasteurization, addition of starter, water and salt, straining, personnel hygiene, drying and packaging. After applying hazard analysis critical control point system, there was significant improvement in the microbiological quality of the home-made jameed. The standard plate count was reduced to 3.1 × 10(2) cfu/g whereas coliform and Staphylococcus aureus counts were less than 10 cfu/g and Salmonella was not detected. Sensory evaluation results of color and flavor of sauce prepared from jameed showed a significant increase in the average scores given after hazard analysis critical control point application.

  17. Annular suspension and pointing system with controlled DC electromagnets

    NASA Technical Reports Server (NTRS)

    Vu, Josephine Lynn; Tam, Kwok Hung

    1993-01-01

    The Annular Suspension and Pointing System (ASPS) developed by the Flight System division of Sperry Corporation is a six-degree of freedom payload pointing system designed for use with the space shuttle. This magnetic suspension and pointing system provides precise controlled pointing in six-degrees of freedom, isolation of payload-carrier disturbances, and end mount controlled pointing. Those are great advantages over the traditional mechanical joints for space applications. In this design, we first analyzed the assumed model of the single degree ASPS bearing actuator and obtained the plant dynamics equations. By linearizing the plant dynamics equations, we designed the cascade and feedback compensators such that a stable and satisfied result was obtained. The specified feedback compensator was computer simulated with the nonlinearized plant dynamics equations. The results indicated that an unstable output occurred. In other words, the designed feedback compensator failed. The failure of the design is due to the Taylor's series expansion not converging.

  18. Assisted Control Point Measurement for Close Range Photogrammetry.

    NASA Astrophysics Data System (ADS)

    Mata, E.; Hernandez, M. A.; Cardenal, J.; Perez, J. L.

    2012-07-01

    This paper describes the automation and optimization in control points measurement and elaboration of sketches in Close Range Photogrammetry. The system can be controlled by an operator alone and it integrates a robotized and reflectorless total station, two digital cameras, a laptop computer and the control software. The measured data with the station are registered and the control point will get associated to their marks in the images. So, it is possible to eliminate the handmade sketches since the marking of control points in the image is instantaneously made. The sketch includes object images with enlargements so the point is clearly identified and marked with the support of a virtual reticle. Also the sketch includes object coordinates, image coordinates, identification code (ID) and some additional information about the point. The use of the system by only one operator allows the reduction of costs, organization and time in control point surveying. Different tests have been made in order to check the system. TDC: this test has been made in close range conditions with targets and artificial illumination. EDIF: in this case the test includes long range conditions and control points targeted at natural points in building façade. The tests have allowed several analyses to study the feasibility and the improvement of the system. So we have made in situ tests by comparing direct observations with and without the camera telescope, with targets and natural points, close and long distances and different conditions of illumination. Moreover in one of these tests we include the observation and sketch realization with a manual method. With respect to the use of the aiming eyepiece camera, the tests (TDC) realized in laboratory (close distance -4 m- and good light conditions) show very small spatial differences (below the nominal precision of the total station) comparing the direct aim through the telescope without camera. Other test (EDIF) made over longer distance (130

  19. Athlete use and opinion of point of choice nutrition labels at a major international competition.

    PubMed

    Burkhart, Sarah J; Pelly, Fiona E

    2013-11-01

    Point of choice (POC) labels may assist individuals to choose food appropriate for their needs when dining away from home. However, limited research exists on the use and opinion of labels by athletes in a large dining hall environment. The aim of this study was to evaluate athletes' utilisation and opinion of POC nutrition labels provided in the athletes village main dining hall at a major competition event (the 2010 Commonwealth Games, New Delhi, India). A questionnaire was distributed to athletes from a range of cultural and sporting backgrounds (n=351) while present within the dining hall during main meal periods throughout the competition event (23rd September-14th October, 2010). While the majority of respondents (79%) reported that it was important/very important to provide POC information for menu items and 59% rated the POC labels as useful/very useful, only 14% of athletes reported using labels all of the time. Athletes from specific regions (India/Sri Lanka, Africa), sports (team and weight category), and those with less education reported using the labels more frequently. Although females rated the importance of providing nutrition information higher than males (p=0.008), there was no gender difference in reported use of POC labels. Athletes believed that POC labels could be improved with the addition of more information, better aesthetic properties, and better positioning in more convenient locations. Further research to identify the most effective POC label for use in this environment, and ultimately the development of a standardised label may assist a broader range of athletes at future competitions. Copyright © 2013 Elsevier Ltd. All rights reserved.

  20. Control Variate Estimators of Survivor Growth from Point Samples

    Treesearch

    Francis A. Roesch; Paul C. van Deusen

    1993-01-01

    Two estimators of the control variate type for survivor growth from remeasured point samples are proposed and compared with more familiar estimators. The large reductionsin variance, observed in many cases forestimators constructed with control variates, arealso realized in thisapplication. A simulation study yielded consistent reductions in variance which were often...

  1. Cognitive control in majority search: a computational modeling approach.

    PubMed

    Wang, Hongbin; Liu, Xun; Fan, Jin

    2011-01-01

    Despite the importance of cognitive control in many cognitive tasks involving uncertainty, the computational mechanisms of cognitive control in response to uncertainty remain unclear. In this study, we develop biologically realistic neural network models to investigate the instantiation of cognitive control in a majority function task, where one determines the category to which the majority of items in a group belong. Two models are constructed, both of which include the same set of modules representing task-relevant brain functions and share the same model structure. However, with a critical change of a model parameter setting, the two models implement two different underlying algorithms: one for grouping search (where a subgroup of items are sampled and re-sampled until a congruent sample is found) and the other for self-terminating search (where the items are scanned and counted one-by-one until the majority is decided). The two algorithms hold distinct implications for the involvement of cognitive control. The modeling results show that while both models are able to perform the task, the grouping search model fit the human data better than the self-terminating search model. An examination of the dynamics underlying model performance reveals how cognitive control might be instantiated in the brain for computing the majority function.

  2. Cognitive Control in Majority Search: A Computational Modeling Approach

    PubMed Central

    Wang, Hongbin; Liu, Xun; Fan, Jin

    2011-01-01

    Despite the importance of cognitive control in many cognitive tasks involving uncertainty, the computational mechanisms of cognitive control in response to uncertainty remain unclear. In this study, we develop biologically realistic neural network models to investigate the instantiation of cognitive control in a majority function task, where one determines the category to which the majority of items in a group belong. Two models are constructed, both of which include the same set of modules representing task-relevant brain functions and share the same model structure. However, with a critical change of a model parameter setting, the two models implement two different underlying algorithms: one for grouping search (where a subgroup of items are sampled and re-sampled until a congruent sample is found) and the other for self-terminating search (where the items are scanned and counted one-by-one until the majority is decided). The two algorithms hold distinct implications for the involvement of cognitive control. The modeling results show that while both models are able to perform the task, the grouping search model fit the human data better than the self-terminating search model. An examination of the dynamics underlying model performance reveals how cognitive control might be instantiated in the brain for computing the majority function. PMID:21369357

  3. Noise Control for a Moving Evaluation Point Using Neural Networks

    NASA Astrophysics Data System (ADS)

    Maeda, Toshiki; Shiraishi, Toshihiko

    2016-09-01

    This paper describes the noise control for a moving evaluation point using neural networks by making the best use of its learning ability. Noise control is a technology which is effective on low-frequency noise. Based on the principle of superposition, a primary sound wave can be cancelled at an evaluation point by emitting a secondary opposite sound wave. To obtain good control performance, it is important to precisely identify the characteristics of all the sound paths. One of the most popular algorithms of noise control is filtered-x LMS algorithm. This algorithm can deliver a good result while all the sound paths do not change. However, the control system becomes uncontrollable while the evaluation point is moving. To solve the problem, the characteristics of all the paths are must be identified at all time. In this paper, we applied neural networks with the learning ability to the noise control system to follow the time-varying paths and verified its control performance by numerical simulations. Then, dropout technique for the networks is also applied. Dropout is a technique that prevent the network from overfitting and enables better control performance. By applying dropout for noise control, it prevents the system from diverging.

  4. Generating controllable type-II Weyl points via periodic driving

    NASA Astrophysics Data System (ADS)

    Bomantara, Raditya Weda; Gong, Jiangbin

    2016-12-01

    Type-II Weyl semimetals are a novel gapless topological phase of matter discovered recently in 2015. Similar to normal (type-I) Weyl semimetals, type-II Weyl semimetals consist of isolated band touching points. However, unlike type-I Weyl semimetals which have a linear energy dispersion around the band touching points forming a three-dimensional (3D) Dirac cone, type-II Weyl semimetals have a tilted conelike structure around the band touching points. This leads to various novel physical properties that are different from type-I Weyl semimetals. In order to study further the properties of type-II Weyl semimetals and perhaps realize them for future applications, generating controllable type-II Weyl semimetals is desirable. In this paper, we propose a way to generate a type-II Weyl semimetal via a generalized Harper model interacting with a harmonic driving field. When the field is treated classically, we find that only type-I Weyl points emerge. However, by treating the field quantum mechanically, some of these type-I Weyl points may turn into type-II Weyl points. Moreover, by tuning the coupling strength, it is possible to control the tilt of the Weyl points and the energy difference between two Weyl points, which makes it possible to generate a pair of mixed Weyl points of type-I and type-II. We also discuss how to physically distinguish these two types of Weyl points in the framework of our model via the Landau level structures in the presence of an artificial magnetic field. The results are of general interest to quantum optics as well as ongoing studies of Floquet topological phases.

  5. Space telescope - Meeting the pointing control challenge with today's technology

    NASA Technical Reports Server (NTRS)

    Dougherty, H.; Rodoni, C.; Rodden, J.; Tompetrini, K.

    1982-01-01

    The pointing control system of the Space Telescope, which provides target-to-target maneuvering capability and precision pointing on the target star (with 0.007-arcsec stability and 0.01-arcsec accuracy), is described. Spacecraft attitude control is undertaken by onboard computer processing of attitude and rate sensor data that generates reaction wheel torque commands. The Space Telescope Operations Control Center communicates with the Space Telescope via the synchronous altitude tracking and data relay satellite system, and determines vehicle attitude more precisely by means of sun sensors, magnetometers and fixed-head star trackers. Such disturbance torques as those of gravity gradients and aerodynamics act on the Space Telescope, causing the speeds of the four reaction wheels to increase. In order to prevent the wheels from reaching a speed-saturated condition, a momentum control system is provided for the management of reaction wheel speed buildup. Attention is given to development testing and control hardware investigations and improvements.

  6. Web-Based Learning Enhancements: Video Lectures through Voice-Over PowerPoint in a Majors-Level Biology Course

    ERIC Educational Resources Information Center

    Lents, Nathan H.; Cifuentes, Oscar E.

    2009-01-01

    This study is an experimental introduction of web-based lecture delivery into a majors-level introductory biology course. Web-based delivery, achieved through the use of prerecorded Voice-Over PowerPoint video lectures, was introduced on a limited basis to an experimental section while a control group, with the same instructor, received standard…

  7. Pointing and Scanning Control of Instruments Using Rotating Unbalanced Masses

    NASA Technical Reports Server (NTRS)

    Hung, John Y.

    1996-01-01

    Motions of telescopes, satellites, and other flight bodies have been controlled by various means in the past. For example, gimbal mounted devices can use electric motors to produce pointing and scanning motions. Reaction wheels, control moment gyros, and propellant-charged reaction jets are other technologies that have also been used. Each of these methods has its advantages, but all actuator systems used in a flight environment face the challenges of minimizing weight, reducing energy consumption, and maximizing reliability. Recently, Polites invented and patented the Rotating Unbalanced Mass (RUM) device as a means for generation scanning motion on flight experiments. RUM devices have been successfully used to generate various scanning motions. The basic principle: a RUM rotating at constant annular velocity exerts a cyclic centrifugal force on the instrument or main body, thus producing a periodic scanning motion. A system of RUM devices exerts no reaction forces on the main body, requires very little energy, and is very simple to construct and control. These are significant advantages over electric motors, reaction wheels, and control moment gyroscopes. Although the RUM device very easily produces scanning motion, an auxiliary control system may be required to maintain the proper orientation, or pointing of the main body. It has been suggested that RUM devices can be used to control pointing dynamics, as well as generate the desired periodic scanning motion. The idea is that the RUM velocity will not be constant, but will vary over the period of one RUM rotation. The thought is that the changing angular velocity produces a centrifugal force having time-varying magnitude and direction. The scope of the present research project is to further study the pointing control concept, and to implement a microcontroller program to control an experimental hardware system. This report is subdivided into three themes. The basic dynamic modeling and control principles are

  8. Feedback control of major disruptions in International Thermonuclear Experimental Reactor

    SciTech Connect

    Sen, A. K.

    2011-08-15

    It is argued that major disruptions in ITER can be avoided by the feedback control of the causative MHD precursors. The sensors will be 2D-arrays of ECE detectors and the suppressors will be modulated ECH beams injected radially to produce non-thermal radial pressures to counter the radial dynamics of MHD modes. The appropriate amplitude and phase of this signal can stabilize the relevant MHD modes and prevent their evolution to a major disruption. For multimode MHD precursors, an optimal feedback scheme with a Kalman filter is discussed.

  9. Pointing control for the SPIDER balloon-borne telescope

    NASA Astrophysics Data System (ADS)

    Shariff, J. A.; Ade, P. A. R.; Amiri, M.; Benton, S. J.; Bock, J. J.; Bond, J. R.; Bryan, S. A.; Chiang, H. C.; Contaldi, C. R.; Crill, B. P.; Doré, O. P.; Farhang, M.; Filippini, J. P.; Fissel, L. M.; Fraisse, A. A.; Gambrel, A. E.; Gandilo, N. N.; Golwala, S. R.; Gudmundsson, J. E.; Halpern, M.; Hasselfield, M.; Hilton, G. C.; Holmes, W. A.; Hristov, V. V.; Irwin, K. D.; Jones, W. C.; Kermish, Z. D.; Kuo, C. L.; MacTavish, C. J.; Mason, P. V.; Megerian, K. G.; Moncelsi, L.; Morford, T. A.; Nagy, J. M.; Netterfield, C. B.; O'Brient, R.; Rahlin, A. S.; Reintsema, C. D.; Ruhl, J. E.; Runyan, M. C.; Soler, J. D.; Trangsrud, A.; Tucker, C. E.; Tucker, R. S.; Turner, A. D.; Weber, A. C.; Wiebe, D. V.; Young, E. Y.

    2014-07-01

    We present the technology and control methods developed for the pointing system of the Spider experiment. Spider is a balloon-borne polarimeter designed to detect the imprint of primordial gravitational waves in the polarization of the Cosmic Microwave Background radiation. We describe the two main components of the telescope's azimuth drive: the reaction wheel and the motorized pivot. A 13 kHz PI control loop runs on a digital signal processor, with feedback from fibre optic rate gyroscopes. This system can control azimuthal speed with < 0.02 deg/s RMS error. To control elevation, Spider uses stepper-motor-driven linear actuators to rotate the cryostat, which houses the optical instruments, relative to the outer frame. With the velocity in each axis controlled in this way, higher-level control loops on the onboard flight computers can implement the pointing and scanning observation modes required for the experiment. We have accomplished the non-trivial task of scanning a 5000 lb payload sinusoidally in azimuth at a peak acceleration of 0.8 deg/s2, and a peak speed of 6 deg/s. We can do so while reliably achieving sub-arcminute pointing control accuracy.

  10. Boundary control problem of linear Stokes equation with point observations

    SciTech Connect

    Ding, Z.

    1994-12-31

    We will discuss the linear quadratic regulator problems (LQR) of linear Stokes system with point observations on the boundary and box constraints on the boundary control. By using hydropotential theory, we proved that the LQR problems without box constraint on the control do not admit any non trivial solution, while the LQR problems with box constraints have a unique solution. The optimal control is given explicitly, and its singular behaviors are displayed explicitly through a decomposition formula. Based upon the characteristic formula of the optimal control, a generic numerical algorithm is given for solving the box constrained LQR problems.

  11. Fine pointing control for a Next-Generation Space Telescope

    NASA Astrophysics Data System (ADS)

    Mosier, Gary E.; Femiano, Michael; Ha, Kong; Bely, Pierre Y.; Burg, Richard; Redding, David C.; Kissil, Andrew; Rakoczy, John; Craig, Larry

    1998-08-01

    The Next Generation Space Telescope will provide at least ten times the collecting area of the Hubble Space Telescope in a package that fits into the shroud of an expendable launch vehicle. The resulting large, flexible structure provides a challenge to the design of a pointing control system for which the requirements are at the milli-arcsecond level. This paper describes a design concept in which pointing stability is achieved by means of a nested-loop design involving an inertial attitude control system (ACS) and a fast steering mirror (FSM). A key to the integrated control design is that the ACS controllers has a bandwidth well below known structural modes and the FSM uses a rotationally balanced mechanism which should not interact with the flexible modes that are within its control bandwidth. The ACS controller provides stable pointing of the spacecraft bus with star trackers and gyros. This low bandwidth loop uses nearly co-located sensors and actuators to slew and acquire faint guide stars in the NIR camera. This controller provides a payload reference stable to the arcsecond level. Low-frequency pointing errors due to sensor noise and dynamic disturbances are suppressed by a 2-axis gimbaled FSM locate din the instrument module. The FSM servo bandwidth of 6 Hz is intended to keep the guide star position stable in the NIR focal plane to the required milli-arcsecond level. The mirror is kept centered in its range of travel by a low-bandwidth loop closed around the ACS. This paper presents the result of parametric trade studies designed to assess the performance of this control design in the presence of modeled reaction wheel disturbances, assumed to be the principle source of vibration for the NGST, and variations in structural dynamics. Additionally, requirements for reaction wheel disturbance levels and potential vibration isolation subsystems were developed.

  12. Engineering to Control Noise, Loading, and Optimal Operating Points

    SciTech Connect

    Mitchell R. Swartz

    2000-11-12

    Successful engineering of low-energy nuclear systems requires control of noise, loading, and optimum operating point (OOP) manifolds. The latter result from the biphasic system response of low-energy nuclear reaction (LENR)/cold fusion systems, and their ash production rate, to input electrical power. Knowledge of the optimal operating point manifold can improve the reproducibility and efficacy of these systems in several ways. Improved control of noise, loading, and peak production rates is available through the study, and use, of OOP manifolds. Engineering of systems toward the OOP-manifold drive-point peak may, with inclusion of geometric factors, permit more accurate uniform determinations of the calibrated activity of these materials/systems.

  13. Triana Safehold: A New Gyroless, Sun-Pointing Attitude Controller

    NASA Technical Reports Server (NTRS)

    Chen, J.; Morgenstern, Wendy; Garrick, Joseph

    2001-01-01

    Triana is a single-string spacecraft to be placed in a halo orbit about the sun-earth Ll Lagrangian point. The Attitude Control Subsystem (ACS) hardware includes four reaction wheels, ten thrusters, six coarse sun sensors, a star tracker, and a three-axis Inertial Measuring Unit (IMU). The ACS Safehold design features a gyroless sun-pointing control scheme using only sun sensors and wheels. With this minimum hardware approach, Safehold increases mission reliability in the event of a gyroscope anomaly. In place of the gyroscope rate measurements, Triana Safehold uses wheel tachometers to help provide a scaled estimation of the spacecraft body rate about the sun vector. Since Triana nominally performs momentum management every three months, its accumulated system momentum can reach a significant fraction of the wheel capacity. It is therefore a requirement for Safehold to maintain a sun-pointing attitude even when the spacecraft system momentum is reasonably large. The tachometer sun-line rate estimation enables the controller to bring the spacecraft close to its desired sun-pointing attitude even with reasonably high system momentum and wheel drags. This paper presents the design rationale behind this gyroless controller, stability analysis, and some time-domain simulation results showing performances with various initial conditions. Finally, suggestions for future improvements are briefly discussed.

  14. Verifying critical control points for Phytophthora introduction into nurseries

    Treesearch

    N.K. Osterbauer; M. Lujan; G. McAninch; A. Trippe; S. Lane

    2013-01-01

    The Oregon Department of Agriculture implemented the Grower Assisted Inspection Program (GAIP) for nurseries in 2007. Participants in GAIP adopted best management practices (BMP) for five critical control points (CCP) (used containers, irrigation water, soil substrate, potting media, and incoming plants), where foliar Phytophthora can be introduced...

  15. Floating-point system quantization errors in digital control systems

    NASA Technical Reports Server (NTRS)

    Phillips, C. L.; Vallely, D. P.

    1978-01-01

    This paper considers digital controllers (filters) operating in floating-point arithmetic in either open-loop or closed-loop systems. A quantization error analysis technique is developed, and is implemented by a digital computer program that is based on a digital simulation of the system. The program can be integrated into existing digital simulations of a system.

  16. Galileo Spacecraft Scan Platform Celestial Pointing Cone Control Gain Redesign

    NASA Technical Reports Server (NTRS)

    In, C-H. C.; Hilbert, K. B.

    1994-01-01

    During September and October 1991, pictures of the Gaspra asteroid and neighboring stars were taken by the Galileo Optical Navigation (OPNAV) Team for the purpose of navigation the spacecraft for a successful Gaspra encounter. The star tracks in these pictures showed that the scan platform celestial pointing cone controller performed poorly in compensating for wobble-induced cone offsets.

  17. Two Axis Pointing System (TAPS) attitude acquisition, determination, and control

    NASA Astrophysics Data System (ADS)

    Azzolini, John D.; McGlew, David E.

    1990-12-01

    The Two Axis Pointing System (TAPS) is a 2 axis gimbal system designed to provide fine pointing of Space Transportation System (STS) borne instruments. It features center-of-mass instrument mounting and will accommodate instruments of up to 1134 kg (2500 pounds) which fit within a 1.0 by 1.0 by 4.2 meter (40 by 40 by 166 inch) envelope. The TAPS system is controlled by a microcomputer based Control Electronics Assembly (CEA), a Power Distribution Unit (PDU), and a Servo Control Unit (SCU). A DRIRU-II inertial reference unit is used to provide incremental angles for attitude propagation. A Ball Brothers STRAP star tracker is used for attitude acquisition and update. The theory of the TAPS attitude determination and error computation for the Broad Band X-ray Telescope (BBXRT) are described. The attitude acquisition is based upon a 2 star geometric solution. The acquisition theory and quaternion algebra are presented. The attitude control combines classical position, integral and derivative (PID) control with techniques to compensate for coulomb friction (bias torque) and the cable harness crossing the gimbals (spring torque). Also presented is a technique for an adaptive bias torque compensation which adjusts to an ever changing frictional torque environment. The control stability margins are detailed, with the predicted pointing performance, based upon simulation studies. The TAPS user interface, which provides high level operations commands to facilitate science observations, is outlined.

  18. Two Axis Pointing System (TAPS) attitude acquisition, determination, and control

    NASA Technical Reports Server (NTRS)

    Azzolini, John D.; Mcglew, David E.

    1990-01-01

    The Two Axis Pointing System (TAPS) is a 2 axis gimbal system designed to provide fine pointing of Space Transportation System (STS) borne instruments. It features center-of-mass instrument mounting and will accommodate instruments of up to 1134 kg (2500 pounds) which fit within a 1.0 by 1.0 by 4.2 meter (40 by 40 by 166 inch) envelope. The TAPS system is controlled by a microcomputer based Control Electronics Assembly (CEA), a Power Distribution Unit (PDU), and a Servo Control Unit (SCU). A DRIRU-II inertial reference unit is used to provide incremental angles for attitude propagation. A Ball Brothers STRAP star tracker is used for attitude acquisition and update. The theory of the TAPS attitude determination and error computation for the Broad Band X-ray Telescope (BBXRT) are described. The attitude acquisition is based upon a 2 star geometric solution. The acquisition theory and quaternion algebra are presented. The attitude control combines classical position, integral and derivative (PID) control with techniques to compensate for coulomb friction (bias torque) and the cable harness crossing the gimbals (spring torque). Also presented is a technique for an adaptive bias torque compensation which adjusts to an ever changing frictional torque environment. The control stability margins are detailed, with the predicted pointing performance, based upon simulation studies. The TAPS user interface, which provides high level operations commands to facilitate science observations, is outlined.

  19. LST data management and mission operations concept. [pointing control optimization for maximum data

    NASA Technical Reports Server (NTRS)

    Walker, R.; Hudson, F.; Murphy, L.

    1977-01-01

    A candidate design concept for an LST ground facility is described. The design objectives were to use NASA institutional hardware, software and facilities wherever practical, and to maximize efficiency of telescope use. The pointing control performance requirements of LST are summarized, and the major data interfaces of the candidate ground system are diagrammed.

  20. Precision pointing control for an orbital earth observing system

    NASA Technical Reports Server (NTRS)

    Robeck, Linda S.; Rathbun, David B.; Lehman, David H.

    1991-01-01

    The design concept developed for the pointing system of the high-resolution imaging spectrometer (HIRIS) which will be flown on one of NASA's earth observing system platforms is presented. The instrument is an F/5.4-aperture spectrometer with a focal length of 1222 mm, and it uses a precision two-axis gimballed mirror pointing system to image and track targets. Pointing accuracy of better than 585 arcsec (peak-to-peak), and pointing jitter of less than 2.65 arcsec in 33 ms are ensured through the use of gimbal position and basebody rate sensors. A state-space controller implemented with a digital computer is used to provide a position loop bandwidth of 1 Hz and a rate loop bandwidth of 7 Hz. An overview of the system design and flight hardware is given, the development of the controller architecture is addressed, and a simulation assessment of the pointing system that takes into consideration issues such as nonlinear effects, sensor noise, and noncollocated sensors and actuators in a flexible structure is discussed.

  1. Optimal periodic control for spacecraft pointing and attitude determination

    NASA Technical Reports Server (NTRS)

    Pittelkau, Mark E.

    1993-01-01

    A new approach to autonomous magnetic roll/yaw control of polar-orbiting, nadir-pointing momentum bias spacecraft is considered as the baseline attitude control system for the next Tiros series. It is shown that the roll/yaw dynamics with magnetic control are periodically time varying. An optimal periodic control law is then developed. The control design features a state estimator that estimates attitude, attitude rate, and environmental torque disturbances from Earth sensor and sun sensor measurements; no gyros are needed. The state estimator doubles as a dynamic attitude determination and prediction function. In addition to improved performance, the optimal controller allows a much smaller momentum bias than would otherwise be necessary. Simulation results are given.

  2. Improved pointing at trackable targets by integrating control valve signals

    NASA Technical Reports Server (NTRS)

    Stone, R. W.; Laverty, C. R.; Colby, M. J.

    1982-01-01

    A compact, low-cost add-on electronic module has been developed for the STRAP III control system to improve pointing at trackable targets. The module provides peak-to-peak limit cycle excursions of + or - 5 arcseconds while tracking a +3 magnitude or brighter star. This is achieved without using rate-integrating gyroscopes, thus reducing payload length, weight, cost, and preparation time. This module has flown successfully five times. In May 1981, it improved the performance of a two-startracker attitude control system with TV camera and joystick control which pointed at a nontrackable target. This paper describes the operation of the module, how it alters the ordinary STRAP III operation, and how it was developed using an analog-computer-based rocket flight simulator.

  3. Accuracy analysis of pointing control system of solar power station

    NASA Technical Reports Server (NTRS)

    Hung, J. C.; Peebles, P. Z., Jr.

    1978-01-01

    The first-phase effort concentrated on defining the minimum basic functions that the retrodirective array must perform, identifying circuits that are capable of satisfying the basic functions, and looking at some of the error sources in the system and how they affect accuracy. The initial effort also examined three methods for generating torques for mechanical antenna control, performed a rough analysis of the flexible body characteristics of the solar collector, and defined a control system configuration for mechanical pointing control of the array.

  4. Model-based HSF using by target point control function

    NASA Astrophysics Data System (ADS)

    Kim, Seongjin; Do, Munhoe; An, Yongbae; Choi, Jaeseung; Yang, Hyunjo; Yim, Donggyu

    2015-03-01

    As the technology node shrinks, ArF Immersion reaches the limitation of wafer patterning, furthermore weak point during the mask processing is generated easily. In order to make strong patterning result, the design house conducts lithography rule checking (LRC). Despite LRC processing, we found the weak point at the verification stage of optical proximity correction (OPC). It is called the hot spot point (HSP). In order to fix the HSP, many studies have been performed. One of the most general hot spot fixing (HSF) methods is that the modification bias which consists of "Line-Resizing" and "Space-Resizing". In addition to the general rule biasing method, resolution enhancement techniques (RET) which includes the inverse lithography technology (ILT) and model based assist feature (MBAF) have been adapted to remove the hot spot and to maximize the process window. If HSP is found during OPC verification stage, various HSF methods can be applied. However, HSF process added on regular OPC procedure makes OPC turn-around time (TAT) increased. In this paper, we introduce a new HSF method that is able to make OPC TAT shorter than the common HSF method. The new HSF method consists of two concepts. The first one is that OPC target point is controlled to fix HSP. Here, the target point should be moved to optimum position at where the edge placement error (EPE) can be 0 at critical points. Many parameters such as a model accuracy or an OPC recipe become the cause of larger EPE. The second one includes controlling of model offset error through target point adjustment. Figure 1 shows the case EPE is not 0. It means that the simulation contour was not targeted well after OPC process. On the other hand, Figure 2 shows the target point is moved -2.5nm by using target point control function. As a result, simulation contour is matched to the original layout. This function can be powerfully adapted to OPC procedure of memory and logic devices.

  5. 47 CFR 90.473 - Operation of internal transmitter control systems through licensed fixed control points.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Transmitter Control Internal Transmitter Control Systems § 90.473 Operation of internal transmitter control systems through licensed fixed control points. An internal transmitter control system may be operated... internal system from the transmitter control circuit or to close the system......

  6. 47 CFR 90.473 - Operation of internal transmitter control systems through licensed fixed control points.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Transmitter Control Internal Transmitter Control Systems § 90.473 Operation of internal transmitter control systems through licensed fixed control points. An internal transmitter control system may be operated... internal system from the transmitter control circuit or to close the system......

  7. The timing of control signals underlying fast point-to-point arm movements.

    PubMed

    Ghafouri, M; Feldman, A G

    2001-04-01

    It is known that proprioceptive feedback induces muscle activation when the facilitation of appropriate motoneurons exceeds their threshold. In the suprathreshold range, the muscle-reflex system produces torques depending on the position and velocity of the joint segment(s) that the muscle spans. The static component of the torque-position relationship is referred to as the invariant characteristic (IC). According to the equilibrium-point (EP) hypothesis, control systems produce movements by changing the activation thresholds and thus shifting the IC of the appropriate muscles in joint space. This control process upsets the balance between muscle and external torques at the initial limb configuration and, to regain the balance, the limb is forced to establish a new configuration or, if the movement is prevented, a new level of static torques. Taken together, the joint angles and the muscle torques generated at an equilibrium configuration define a single variable called the EP. Thus by shifting the IC, control systems reset the EP. Muscle activation and movement emerge following the EP resetting because of the natural physical tendency of the system to reach equilibrium. Empirical and simulation studies support the notion that the control IC shifts and the resulting EP shifts underlying fast point-to-point arm movements are gradual rather than step-like. However, controversies exist about the duration of these shifts. Some studies suggest that the IC shifts cease with the movement offset. Other studies propose that the IC shifts end early in comparison to the movement duration (approximately, at peak velocity). The purpose of this study was to evaluate the duration of the IC shifts underlying fast point-to-point arm movements. Subjects made fast (hand peak velocity about 1.3 m/s) planar arm movements toward different targets while grasping a handle. Hand forces applied to the handle and shoulder/elbow torques were, respectively, measured from a force sensor placed

  8. Cognitive control adjustments and conflict adaptation in major depressive disorder.

    PubMed

    Clawson, Ann; Clayson, Peter E; Larson, Michael J

    2013-08-01

    Individuals with major depressive disorder (MDD) show alterations in the cognitive control function of conflict processing. We examined the influence of these deficits on behavioral and event-related potential (ERP) indices of conflict adaptation, a cognitive control process wherein previous-trial congruency modulates current-trial performance, in 55 individuals with MDD and 55 matched controls. ERPs were calculated while participants completed a modified flanker task. There were nonsignificant between-groups differences in response time, error rate, and N2 indices of conflict adaptation. Higher depressive symptom scores were associated with smaller mean N2 conflict adaptation scores for individuals with MDD and when collapsed across groups. Results were consistent when comorbidity and medications were analyzed. These findings suggest N2 conflict adaptation is associated with depressive symptoms rather than clinical diagnosis alone.

  9. Astronaut Uses Manual Point Control During Astro-1 Mission

    NASA Technical Reports Server (NTRS)

    1990-01-01

    The primary objective of the STS-35 mission was round the clock observation of the celestial sphere in ultraviolet and X-Ray astronomy with the Astro-1 observatory which consisted of four telescopes: the Hopkins Ultraviolet Telescope (HUT); the Wisconsin Ultraviolet Photo-Polarimeter Experiment (WUPPE); the Ultraviolet Imaging Telescope (UIT); and the Broad Band X-Ray Telescope (BBXRT). The Huntsville Operations Support Center (HOSC) Spacelab Payload Operations Control Center (SL POCC) at the Marshall Space Flight Center (MSFC) was the air/ground communication channel used between the astronauts and ground control teams during the Spacelab missions. Teams of controllers and researchers directed on-orbit science operations, sent commands to the spacecraft, received data from experiments aboard the Space Shuttle, adjusted mission schedules to take advantage of unexpected science opportunities or unexpected results, and worked with crew members to resolve problems with their experiments. Due to loss of data used for pointing and operating the ultraviolet telescopes, MSFC ground teams were forced to aim the telescopes with fine tuning by the flight crew. Pictured onboard the shuttle is astronaut Robert Parker using a Manual Pointing Controller (MPC) for the ASTRO-1 mission Instrument Pointing System (IPS).

  10. Dynamics and control simulation of the Spacelab Experiment Pointing Mount

    NASA Technical Reports Server (NTRS)

    Marsh, E. L.; Ward, R. S.

    1977-01-01

    Computer simulations were developed to evaluate the performance of four Experiment Pointing Mounts (EPM) being considered for Spacelab experiments in the 1980-1990 time frame. The system modeled compromises a multibody system consisting of the shuttle, a mechanical isolation device, the EPM, celestial and inertial sensors, bearings, gimbal torque motors and associated nonlinearities, the experiment payload, and control and estimator algorithms. Each mount was subjected to a common disturbance (shuttle vernier thruster firing and man push off) and command (stellar pointing or solar raster scan) input. The fundamental limitation common to all mounts was found to be sensor noise. System dynamics and hardware nonlinearities have secondary effects on pointing performance for sufficiently high bandwidth.

  11. Dynamics and control simulation of the Spacelab Experiment Pointing Mount

    NASA Technical Reports Server (NTRS)

    Marsh, E. L.; Ward, R. S.

    1977-01-01

    Computer simulations were developed to evaluate the performance of four Experiment Pointing Mounts (EPM) being considered for Spacelab experiments in the 1980-1990 time frame. The system modeled compromises a multibody system consisting of the shuttle, a mechanical isolation device, the EPM, celestial and inertial sensors, bearings, gimbal torque motors and associated nonlinearities, the experiment payload, and control and estimator algorithms. Each mount was subjected to a common disturbance (shuttle vernier thruster firing and man push off) and command (stellar pointing or solar raster scan) input. The fundamental limitation common to all mounts was found to be sensor noise. System dynamics and hardware nonlinearities have secondary effects on pointing performance for sufficiently high bandwidth.

  12. Testing Set-Point Theory in a Swiss National Sample: Reaction and Adaptation to Major Life Events

    PubMed Central

    Anusic, Ivana; Yap, Stevie C. Y.; Lucas, Richard E.

    2014-01-01

    Set-point theory posits that individuals react to the experience of major life events, but quickly adapt back to pre-event baseline levels of subjective well-being in the years following the event. A large, nationally representative panel study of Swiss households was used to examine set-point theory by investigating the extent of adaptation following the experience of marriage, childbirth, widowhood, unemployment, and disability. Our results demonstrate that major life events are associated with marked change in life satisfaction and, for some events (e.g., marriage, disability), these changes are relatively long lasting even when accounting for normative, age related change. PMID:25419036

  13. Testing Set-Point Theory in a Swiss National Sample: Reaction and Adaptation to Major Life Events.

    PubMed

    Anusic, Ivana; Yap, Stevie C Y; Lucas, Richard E

    2014-12-01

    Set-point theory posits that individuals react to the experience of major life events, but quickly adapt back to pre-event baseline levels of subjective well-being in the years following the event. A large, nationally representative panel study of Swiss households was used to examine set-point theory by investigating the extent of adaptation following the experience of marriage, childbirth, widowhood, unemployment, and disability. Our results demonstrate that major life events are associated with marked change in life satisfaction and, for some events (e.g., marriage, disability), these changes are relatively long lasting even when accounting for normative, age related change.

  14. Bayesian change point estimation in Poisson-based control charts

    NASA Astrophysics Data System (ADS)

    Assareh, Hassan; Noorossana, Rassoul; L Mengersen, Kerrie

    2013-11-01

    Precise identification of the time when a process has changed enables process engineers to search for a potential special cause more effectively. In this paper, we develop change point estimation methods for a Poisson process in a Bayesian framework. We apply Bayesian hierarchical models to formulate the change point where there exists a step change, a linear trend and a known multiple number of changes in the Poisson rate. The Markov chain Monte Carlo is used to obtain posterior distributions of the change point parameters and corresponding probabilistic intervals and inferences. The performance of the Bayesian estimator is investigated through simulations and the result shows that precise estimates can be obtained when they are used in conjunction with the well-known c-, Poisson exponentially weighted moving average (EWMA) and Poisson cumulative sum (CUSUM) control charts for different change type scenarios. We also apply the Deviance Information Criterion as a model selection criterion in the Bayesian context, to find the best change point model for a given dataset where there is no prior knowledge about the change type in the process. In comparison with built-in estimators of EWMA and CUSUM charts and ML based estimators, the Bayesian estimator performs reasonably well and remains a strong alternative. These superiorities are enhanced when probability quantification, flexibility and generalizability of the Bayesian change point detection model are also considered.

  15. 7 CFR 372.8 - Major planning and decision points and public involvement.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... with program personnel. Specific decision points or milestones will be identified and communicated to... regulations. (2) Opportunities for public involvement in the environmental assessment process will be announced in the same fashion as the availability of environmental assessments and findings of no...

  16. Controlling systems that drift through a tipping point

    SciTech Connect

    Nishikawa, Takashi; Ott, Edward

    2014-09-01

    Slow parameter drift is common in many systems (e.g., the amount of greenhouse gases in the terrestrial atmosphere is increasing). In such situations, the attractor on which the system trajectory lies can be destroyed, and the trajectory will then go to another attractor of the system. We consider the case where there are more than one of these possible final attractors, and we ask whether we can control the outcome (i.e., the attractor that ultimately captures the trajectory) using only small controlling perturbations. Specifically, we consider the problem of controlling a noisy system whose parameter slowly drifts through a saddle-node bifurcation taking place on a fractal boundary between the basins of multiple attractors. We show that, when the noise level is low, a small perturbation of size comparable to the noise amplitude applied at a single point in time can ensure that the system will evolve toward a target attracting state with high probability. For a range of noise levels, we find that the minimum size of perturbation required for control is much smaller within a time period that starts some time after the bifurcation, providing a “window of opportunity” for driving the system toward a desirable state. We refer to this procedure as tipping point control.

  17. Coherent anti-stokes Raman spectroscopy system for point temperature and major species concentration measurement

    SciTech Connect

    Singh, J.P.; Yueh, Fang-Yu

    1993-10-01

    The Coherent anti-Stokes Raman Spectroscopy system (CARS) has been developed as a laser-based, advanced, combustion-diagnostic technique to measure temperature and major species concentration. Principles of operation, description of the system and its capabilities, and operational details of this instrument are presented in this report.

  18. Spacecraft Pointing Control Using a Variable-Speed Control Moment Gyro

    NASA Astrophysics Data System (ADS)

    Yamada, Katsuhiko; Takatsuka, Naoki; Shima, Takeya

    The objective of this study is to align a certain axis of a spacecraft in an arbitrary direction by using a variable-speed single-gimbal CMG. Because the total angular momentum of the spacecraft is conserved in inertial space, the final attitude of the spacecraft is restricted, and it is possible to achieve pointing control of the axis that is orthogonal to the gimbal axis. Using new parameters to express pointing errors, we have proposed a simple pointing control law that can be used to align the pointing axis in an arbitrary direction in inertial space. The validity of the proposed control law is verified by numerical simulations.

  19. Guaranteeing Pointing Performance of the SDO Sun-Pointing Controllers in Light of Nonlinear Effects

    NASA Technical Reports Server (NTRS)

    Starin, Scott R.; Bourkland, Kristin L.

    2007-01-01

    The Solar Dynamics Observatory (SDO) mission is the first Space Weather Research Network mission, part of NASA s Living With a Star program.1 This program seeks to understand the changing Sun and its effects on the Solar System, life, and society. To this end, the SDO spacecraft will carry three Sun-observing instruments to geosynchronous orbit: Helioseismic and Magnetic Imager (HMI), led by Stanford University; Atmospheric Imaging Assembly (AIA), led by Lockheed Martin Space and Astrophysics Laboratory; and Extreme Ultraviolet Variability Experiment (EVE), led by the University of Colorado. Links describing the instruments in detail may be found through the SDO web site.2 The basic mission goals are to observe the Sun for a very high percentage of the 5-year mission (10-year goal) with long stretches of uninterrupted observations and with constant, high-data-rate transmission to a dedicated ground station. These goals guided the design of the spacecraft bus that will carry and service the three-instrument payload. At the time of this publication, the SDO spacecraft bus is well into the integration and testing phase at the NASA Goddard Space Flight Center (GSFC). A three-axis stabilized attitude control system (ACS) is needed both to point at the Sun accurately and to keep the roll about the Sun vector correctly positioned. The ACS has four reaction wheel modes and 2 thruster actuated modes. More details about the ACS in general and the control modes in particular can be found in Refs. [3-6]. All four of SDO s wheel-actuated control modes involve Sun-pointing controllers, as might be expected from such a mission. Science mode, during which most science data is collected, uses specialized guide telescopes to point accurately at the Sun. Inertial mode has two sub-modes, one tracks a Sun-referenced target orientation, and another maintains an absolute (star-referenced) target orientation, that both employ a Kalman filter to process data from a digital Sun sensor and

  20. Control of asteroid retrieval trajectories to libration point orbits

    NASA Astrophysics Data System (ADS)

    Ceriotti, Matteo; Sanchez, Joan Pau

    2016-09-01

    The fascinating idea of shepherding asteroids for science and resource utilization is being considered as a credible concept in a not too distant future. Past studies identified asteroids which could be efficiently injected into manifolds which wind onto periodic orbits around collinear Lagrangian points of the Sun-Earth system. However, the trajectories are unstable, and errors in the capture maneuver would lead to complete mission failure, with potential danger of collision with the Earth, if uncontrolled. This paper investigates the controllability of some asteroids along the transfers and the periodic orbits, assuming the use of a solar-electric low-thrust system shepherding the asteroid. Firstly, an analytical approach is introduced to estimate the stability of the trajectories from a dynamical point of view; then, a numerical control scheme based on a linear quadratic regulator is proposed, where the gains are optimized for each trajectory through a genetic algorithm. A stochastic simulation with a Monte Carlo approach is used to account for different perturbed initial conditions and the epistemic uncertainty on the asteroid mass. Results show that only a small subset of the considered combinations of trajectories/asteroids are reliably controllable, and therefore controllability must be taken into account in the selection of potential targets.

  1. Fixed Point Transformations Based Iterative Control of a Polymerization Reaction

    NASA Astrophysics Data System (ADS)

    Tar, József K.; Rudas, Imre J.

    As a paradigm of strongly coupled non-linear multi-variable dynamic systems the mathematical model of the free-radical polymerization of methyl-metachrylate with azobis (isobutyro-nitrile) as an initiator and toluene as a solvent taking place in a jacketed Continuous Stirred Tank Reactor (CSTR) is considered. In the adaptive control of this system only a single input variable is used as the control signal (the process input, i.e. dimensionless volumetric flow rate of the initiator), and a single output variable is observed (the process output, i.e. the number-average molecular weight of the polymer). Simulation examples illustrate that on the basis of a very rough and primitive model consisting of two scalar variables various fixed-point transformations based convergent iterations result in a novel, sophisticated adaptive control.

  2. Vibration control of an active mirror pointing system

    NASA Astrophysics Data System (ADS)

    Su, Joseph C.; Huang, Chien Y.; Austin, Fred; Knowles, Gareth J.

    1993-09-01

    An active vibration control experiment for precision mirror pointing using smart structure is described. The setup consists of a flexible plate clamped to the shaft of an electric motor. Part of the plate is polished to reflect a laser beam whose direction accuracy is the performance criterion. Electroceramic actuators and sensors are incorporated into the plate to control vibration. The analytical model is generated using the ANSYS program. Six flexible modes are kept to investigate the interaction between the rigid and the flexible modes. Three different control strategies were examined. The goal is to suppress the first and the second mode with very little spillover effects from other modes. Simulation results show that the performance objectives can be met. These analytical studies are verified in actual experiments in the near future.

  3. [Critical control points in the pasteurized milk processing fluxogram].

    PubMed

    Lopes, A C; Stamford, T L

    1997-12-01

    With the aim of evaluating the microbiological quality of raw and pasteurized milk and confirm the critical control points in a dairy processing industry (Recife-PE, Brazil), 84 samples of milk were collected from four points of the flow-chart considered critical (raw milk storage tank, outlet of the pasteurizer unit, pasteurized milk storage tank and packing filling machine). All samples were evaluated for the presence of mesophilic and psychotrophics microorganisms. The most probable number (MPN) of total and faecal coliforms were determined. Samples of raw and pasteurized milk (collected from the packing filling machine) were also assessed for the presence of Staphylococcus aureus. The preservation temperature of raw and pasteurized milk in the storage tanks and the MPN of total and faecal coliforms present in the water used by the industry were simultaneously evaluated. High counts of mesophilic and psychotrophics microorganisms, total and faecal coliforms and S. aureus were detect in raw milk production and processing. The pasteurization process reduced the microorganisms to acceptable numbers in the Brazilian standards, however, the statistics analysis showed that the number of microorganisms increased significantly (p < 0.01) in the pasteurized milk storage tank, representing an important point of contamination. The probable reason for this findings was the presence of coliforms in 60% samples of water which was used to clean the milk equipment and the inadequate temperatures in the storage tank. Therefore, the results of the microbiological analysis confirm that the milk maintenance temperature in the storage tanks, the pasteurization and the packaging are critical control points in the pasteurized milk processing fluxogram.

  4. Equilibrium point control cannot be refuted by experimental reconstruction of equilibrium point trajectories.

    PubMed

    Kistemaker, Dinant A; Van Soest, Arthur Knoek J; Bobbert, Maarten F

    2007-09-01

    In the literature, it has been hotly debated whether the brain uses internal models or equilibrium point (EP) control to generate arm movements. EP control involves specification of EP trajectories, time series of arm configurations in which internal forces and external forces are in equilibrium; if the arm is not in a specified EP, it is driven toward this EP by muscle forces arising due to central drive, reflexes, and muscle mechanics. EP control has been refuted by researchers claiming that EP trajectories underlying movements of subjects were complex. These researchers used an approach that involves applying force perturbations during movements of subjects and fitting a mass-spring-damper model to the kinematic responses, and then reconstructing the EP trajectory using the estimated stiffness, damping, and measured kinematics. In this study, we examined the validity of this approach using an EP-controlled musculoskeletal model of the arm. We used the latter model to simulate unperturbed and perturbed maximally fast movements and optimized the parameter values of a mass-spring-damper model to make it reproduce as best as possible the kinematic responses. It was shown that estimated stiffness not only depended on the "true" stiffness of the musculoskeletal model but on all of its dynamical parameters. Furthermore it was shown that reconstructed EP trajectories were in agreement with those presented in the literature but did not resemble the simple EP trajectories that had been used to generate the movement of the model. It was concluded that the refutation of EP control on the basis of results obtained with mass-spring-damper models was unjust.

  5. Optimal periodic controller for formation flying on libration point orbits

    NASA Astrophysics Data System (ADS)

    Peng, Haijun; Zhao, Jun; Wu, Zhigang; Zhong, Wanxie

    2011-09-01

    An optimal periodic controller based on continuous low-thrust is proposed for the stabilization missions of spacecraft station-keeping and formation-keeping along periodic Libration point orbits of the Sun-Earth system. Additionally, a new numerical algorithm is proposed for solving the periodic Riccati differential equation in the design of the optimal periodic controller. Practical missions show that the optimal periodic controller (which is designed with the linear periodic time-varying equation of the relative dynamical model) overcomes the problems and limitations of the time-variant LQR controller. Furthermore, nonlinear numerical simulations are presented for the missions of a leader spacecraft station-keeping and three follower spacecraft formation-keeping. Numerical simulations show that the velocity increments for spacecraft control and relative position errors vary little with changes in the altitude of periodic orbits. In addition, the actual trajectories of the leader and the follower spacecraft track the periodic reference orbit with high accuracy under the perturbation of the eccentric nature of the Earth's orbit and the initial injection errors. In particular, the relative position errors obtained by the optimal periodic controller for spacecraft formation-keeping are all in the range of millimeters.

  6. USE OF THE SDO POINTING CONTROLLERS FOR INSTRUMENT CALIBRATION MANEUVERS

    NASA Technical Reports Server (NTRS)

    Vess, Melissa F.; Starin, Scott R.; Morgenstern, Wendy M.

    2005-01-01

    During the science phase of the Solar Dynamics Observatory mission, the three science instruments require periodic instrument calibration maneuvers with a frequency of up to once per month. The command sequences for these maneuvers vary in length from a handful of steps to over 200 steps, and individual steps vary in size from 5 arcsec per step to 22.5 degrees per step. Early in the calibration maneuver development, it was determined that the original attitude sensor complement could not meet the knowledge requirements for the instrument calibration maneuvers in the event of a sensor failure. Because the mission must be single fault tolerant, an attitude determination trade study was undertaken to determine the impact of adding an additional attitude sensor versus developing alternative, potentially complex, methods of performing the maneuvers in the event of a sensor failure. To limit the impact to the science data capture budget, these instrument calibration maneuvers must be performed as quickly as possible while maintaining the tight pointing and knowledge required to obtain valid data during the calibration. To this end, the decision was made to adapt a linear pointing controller by adjusting gains and adding an attitude limiter so that it would be able to slew quickly and still achieve steady pointing once on target. During the analysis of this controller, questions arose about the stability of the controller during slewing maneuvers due to the combination of the integral gain, attitude limit, and actuator saturation. Analysis was performed and a method for disabling the integral action while slewing was incorporated to ensure stability. A high fidelity simulation is used to simulate the various instrument calibration maneuvers.

  7. Icodextrin:a major problem for glucose dehydrogenase-based glucose point of care testing systems.

    PubMed

    Floré, K; Delanghe, J

    2006-01-01

    Recently a number of glucose dehydrogenase-based point of care (POCT) systems for glucose monitoring were successfully introduced on the market. Icodextrin, a glucose polymer is widely used as an osmotic agent in continuous ambulatory peritoneal dialysis (CAPD). Its metabolites are substrates for glucose dehydrogenase, inducing an analytical error which is gaining importance in the determination of glucose in a hospital environment. Since icodextrin is hydrolysed by amylase in the extracellular fluids, the analytical error in vivo is aggravated by the presence of the smaller oligosaccharides which originate from amylase activity. Clinicians should be warned about the spurious high glucose results which might occur in icodextrin-treated patients. In particular in in conditions associated with increased amylase activities, analytical errors are to be expected in icodextrin-treated patients. Alternative glucose determination methods should be recommended in the latter group of patients.

  8. Automatic ground control point recognition with parallel associative memory

    NASA Technical Reports Server (NTRS)

    Al-Tahir, Raid; Toth, Charles K.; Schenck, Anton F.

    1990-01-01

    The basic principle of the associative memory is to match the unknown input pattern against a stored training set, and responding with the 'closest match' and the corresponding label. Generally, an associative memory system requires two preparatory steps: selecting attributes of the pattern class, and training the system by associating patterns with labels. Experimental results gained from using Parallel Associative Memory are presented. The primary concern is an automatic search for ground control points in aerial photographs. Synthetic patterns are tested followed by real data. The results are encouraging as a relatively high level of correct matches is reached.

  9. Efficacy of myofascial trigger point deactivation for tinnitus control.

    PubMed

    Rocha, Carina Bezerra; Sanchez, Tanit Ganz

    2012-12-01

    Chronic pain in areas surrounding the ear may influence tinnitus. To investigate the efficacy of myofascial trigger point deactivation for the relief of tinnitus. A double-blind randomized clinical trial enrolled 71 patients with tinnitus and myofascial pain syndrome. The experimental group (n = 37) underwent 10 sessions of myofascial trigger point deactivation and the control group (n = 34), 10 sessions with sham deactivation. Treatment of the experimental group was effective for tinnitus relief (p < 0.001). Pain and tinnitus relieves were associated (p = 0.013), so were the ear with worst tinnitus and the side of the body with more pain (p < 0.001). The presence of temporary tinnitus modulation (increase or decrease) upon initial muscle palpation was frequent in both groups, but its temporary decrease was related to the persistent relief at the end of treatment (p = 0.002). Besides medical and audiological investigation, patients with tinnitus should also be checked for: 1) presence of myofascial pain surrounding the ear; 2) laterality between both symptoms; 3) initial decrease of tinnitus during muscle palpation. Treating this specific subgroup of tinnitus patients with myofascial trigger point release may provide better results than others described so far.

  10. Pointing Control System for a High Precision Flight Telescope

    SciTech Connect

    BENTLEY,ANTHONY E.; WILCOXEN,JEFFREY LEE

    2000-12-01

    A pointing control system is developed and tested for a flying gimbaled telescope. The two-axis pointing system is capable of sub-microradian pointing stability and high accuracy in the presence of large host vehicle jitter. The telescope also has high agility--it is capable of a 50-degree retarget (in both axes simultaneously) in less than 2 seconds. To achieve the design specifications, high-accuracy, high-resolution, two-speed resolvers were used, resulting in gimbal-angle measurements stable to 1.5 microradians. In addition, on-axis inertial angle displacement sensors were mounted on the telescope to provide host-vehicle jitter cancellation. The inertial angle sensors are accurate to about 100 nanoradians, but do not measure low frequency displacements below 2 Hz. The gimbal command signal includes host-vehicle attitude information, which is band-limited. This provides jitter data below 20 Hz, but includes a variable latency between 15 and 25 milliseconds. One of the most challenging aspects of this design was to combine the inertial-angle-sensor data with the less perfect information in the command signal to achieve maximum jitter reduction. The optimum blending of these two signals, along with the feedback compensation were designed using Quantitative Feedback Theory.

  11. Floating-point system quantization errors in digital control systems

    NASA Technical Reports Server (NTRS)

    Phillips, C. L.

    1973-01-01

    The results are reported of research into the effects on system operation of signal quantization in a digital control system. The investigation considered digital controllers (filters) operating in floating-point arithmetic in either open-loop or closed-loop systems. An error analysis technique is developed, and is implemented by a digital computer program that is based on a digital simulation of the system. As an output the program gives the programing form required for minimum system quantization errors (either maximum of rms errors), and the maximum and rms errors that appear in the system output for a given bit configuration. The program can be integrated into existing digital simulations of a system.

  12. Detecting Major Genetic Loci Controlling Phenotypic Variability in Experimental Crosses

    PubMed Central

    Rönnegård, Lars; Valdar, William

    2011-01-01

    Traditional methods for detecting genes that affect complex diseases in humans or animal models, milk production in livestock, or other traits of interest, have asked whether variation in genotype produces a change in that trait’s average value. But focusing on differences in the mean ignores differences in variability about that mean. The robustness, or uniformity, of an individual’s character is not only of great practical importance in medical genetics and food production but is also of scientific and evolutionary interest (e.g., blood pressure in animal models of heart disease, litter size in pigs, flowering time in plants). We describe a method for detecting major genes controlling the phenotypic variance, referring to these as vQTL. Our method uses a double generalized linear model with linear predictors based on probabilities of line origin. We evaluate our method on simulated F2 and collaborative cross data, and on a real F2 intercross, demonstrating its accuracy and robustness to the presence of ordinary mean-controlling QTL. We also illustrate the connection between vQTL and QTL involved in epistasis, explaining how these concepts overlap. Our method can be applied to a wide range of commonly used experimental crosses and may be extended to genetic association more generally. PMID:21467569

  13. Pointing Control System Architecture for the Eclipse Mission

    NASA Technical Reports Server (NTRS)

    Kia, Tooraj; Brugarolas, Paul B.; Alexander, James W.; Li, Diane G.

    2006-01-01

    This paper describes the high performance pointing control system used to point the Eclipse telescope. Eclipse is a new mission under study at Jet Propulsion Laboratory for a proposal as a discovery mission. Eclipse is a space telescope for high-contrast optical astronomy. It will be used to investigate the planetary bodies and environments. The main objective of the Eclipse mission is to study planets around nearby stars. Eclipse is designed to reveal planets or dust structures by reducing the scattered and diffracted light within a few arcseconds of a star to a level three orders of magnitude lower than any instrument on the Hubble Space Telescope (HST). Eclipse achieves this high contrast using a 1.8 meter diameter telescope, a coronagraphic system for control of diffracted light, and active wavefront correction using a Precision Deformable Mirror (DM) for the suppression of scattered light. The observatory will be launched into a Sun-synchronous 690 Km, 98.2(deg) Earth Orbit in 2012.

  14. Risk assessment and critical control points from the production perspective.

    PubMed

    Serra, J A; Domenech, E; Escriche, I; Martorell, S

    1999-01-12

    The implementation of a risk analysis program as risk assessment and critical control points (RACCP) is most necessary in order to accomplish the foodborne industries current objective of total quality. The novelty of this technique, when compared to actual hazard analysis and critical control points (HACCP) and its extension to incorporate elements of quantitative risk analysis (QRA), is that RACCP considers the risk of the consequences produced by the production process performance deviations, both inside and outside the company, and also identifies their causative factors. On the other hand, the techniques to be taken in order to prevent or mitigate the consequences of such deviations must be consistent with the former data, but the need for a cost-benefit assessment must not be ignored so that the chosen technique be most profitable for the company. An example developed in a mineral water bottling plant showed that RACCP application is feasible and useful. During this example case, RACCP demonstrated it could obtain a profitable production process that keeps quality and safety of the final product at its maximum, while providing protection to both company and consumer.

  15. Pointing Control System Architecture for the Eclipse Mission

    NASA Technical Reports Server (NTRS)

    Kia, Tooraj; Brugarolas, Paul B.; Alexander, James W.; Li, Diane G.

    2006-01-01

    This paper describes the high performance pointing control system used to point the Eclipse telescope. Eclipse is a new mission under study at Jet Propulsion Laboratory for a proposal as a discovery mission. Eclipse is a space telescope for high-contrast optical astronomy. It will be used to investigate the planetary bodies and environments. The main objective of the Eclipse mission is to study planets around nearby stars. Eclipse is designed to reveal planets or dust structures by reducing the scattered and diffracted light within a few arcseconds of a star to a level three orders of magnitude lower than any instrument on the Hubble Space Telescope (HST). Eclipse achieves this high contrast using a 1.8 meter diameter telescope, a coronagraphic system for control of diffracted light, and active wavefront correction using a Precision Deformable Mirror (DM) for the suppression of scattered light. The observatory will be launched into a Sun-synchronous 690 Km, 98.2(deg) Earth Orbit in 2012.

  16. Extended screening for major mitochondrial DNA point mutations in patients with hereditary hearing loss.

    PubMed

    Kato, Tomofumi; Nishigaki, Yutaka; Noguchi, Yoshihiro; Fuku, Noriyuki; Ito, Taku; Mikami, Eri; Kitamura, Ken; Tanaka, Masashi

    2012-12-01

    Hearing loss (HL) is the most common sensory disorder in humans. Many patients with mitochondrial diseases have sensorineural HL (SNHL). The HL of these patients manifests as a consequence of either syndromic or nonsyndromic mitochondrial diseases. Furthermore, the phenotypes vary among patients even if they are carrying the same mutation. Therefore, these features make it necessary to analyze every presumed mutation in patients with hereditary HL, but the extensive analysis of various mutations is laborious. We analyzed 373 patients with suspected hereditary HL by using an extended suspension-array screening system for major mitochondrial DNA (mtDNA) mutations, which can detect 32 other mtDNA mutations in addition to the previously analyzed 29 mutations. In the present study, we detected 2 different mtDNA mutations among these 373 patients; m.7444G>A in the MT-CO1 gene and m.7472insC in the MT-TS1 gene in 1 patient (0.3%) for each. As these two patients had no clinical features other than HL, they had not been suspected of having mtDNA mutations. This extended screening system together with the previous one is useful for the genetic diagnosis and epidemiological study of both syndromic and nonsyndromic HL.

  17. A Point Mutation in Myh10 Causes Major Defects in Heart Development and Body Wall Closure

    PubMed Central

    Ma, Xuefei; Adelstein, Robert S.

    2014-01-01

    Background The three isoforms of nonmuscle myosin II (NMII-A, NMII-B and NMII-C) play various roles during mouse embryonic development. Previous work, using knockout and hypomorphic mice, showed that MYH10 encoding myosin heavy chain II-B is critical for cardiac and brain development. Ablating or decreasing NMII-B by 80% results in cardiac (ventricular septal defect, double outlet of the right ventricle) and brain defects but not midline fusion defects. Neither NMII-A nor II-C appear to play roles in early myocardial development. Methods and Results We had previously generated point mutant knock-in mice and now report novel findings due to expressing motor deficient NMII-B at wild-type levels. Homozygous mice die at E14.5 in cardiac failure exhibiting abnormalities not seen in NMII-B null and hypomorphic mice: a failure in midline fusion resulting in a cleft palate, ectopia cordis, and a large omphalocele. Fusion of the sternum and endocardial cushions is impaired in the mutant mice associated with a failure in apoptosis of the mesenchyme cells. Failure to disassemble myocyte cell-cell adhesions during cardiac outflow tract development contributes to impaired outflow tract myocardialization and displacement of the aorta to the right ventricle. Conclusions Expression of motor impaired NMII-B disrupts normal ventral body wall closure, due to a dominant negative effect. This is not due to the loss of NMII-B function but rather to a gain-of-function resulting from prolonged crosslinking of NMII-B to actin-filaments thereby interfering with the dynamics of actomyosin cytoskeletal structure. Moreover impaired NMII-B motor activity inhibits outflow tract myocardialization leading to mis-localization of the aorta. PMID:24825879

  18. Nonlinear Burn Control and Operating Point Optimization in ITER

    NASA Astrophysics Data System (ADS)

    Boyer, Mark; Schuster, Eugenio

    2013-10-01

    Control of the fusion power through regulation of the plasma density and temperature will be essential for achieving and maintaining desired operating points in fusion reactors and burning plasma experiments like ITER. In this work, a volume averaged model for the evolution of the density of energy, deuterium and tritium fuel ions, alpha-particles, and impurity ions is used to synthesize a multi-input multi-output nonlinear feedback controller for stabilizing and modulating the burn condition. Adaptive control techniques are used to account for uncertainty in model parameters, including particle confinement times and recycling rates. The control approach makes use of the different possible methods for altering the fusion power, including adjusting the temperature through auxiliary heating, modulating the density and isotopic mix through fueling, and altering the impurity density through impurity injection. Furthermore, a model-based optimization scheme is proposed to drive the system as close as possible to desired fusion power and temperature references. Constraints are considered in the optimization scheme to ensure that, for example, density and beta limits are avoided, and that optimal operation is achieved even when actuators reach saturation. Supported by the NSF CAREER award program (ECCS-0645086).

  19. Flight Performance of Skylab Attitude and Pointing Control System

    NASA Technical Reports Server (NTRS)

    Chubb, W. B.; Kennel, H. F.; Rupp, C. C.; Seltzer, S. M.

    1975-01-01

    In 1967 a paper at the AIAA Guidance, Control and Flight Dynamics Conference in Huntsville, Ala. presented for the first time the prot)osed SKYLAB Attitude and Pointing Control System (APCS) The system requirements, Apollo Telescope Mount (ATM) configuration, control philosophy, and operational modes were presented and the APCS described. The Initial mission and system design requirements changed during the period of time before the SKYLAB was launched. This paper will review the Initial and final APCS requirements and goals and their relationship. The actual flight mission (and Its alterations during the flight) and known achieved APCS performance will then be presented. SKYLAB was a tremendous success in furthering man's scientific knowledge; but perhaps SKYLAB will be remembered more for the anomalies and the efforts undertaken to solve them. On May 14, 1973, the unmanned SKYLAB Orbital Workshop (OWS) was launched from Cape Kennedy. Serious hardware failures began to occur during ascent through the atmosphere and their spectre continued to haunt both the astronauts and their ground based support team. Nor were these the only surprises affecting the design and operation of the APCS. Mission requirements for pointing to various stellar targets and to nadir for earth resources experiments were added after the hardware was designed. The chance appearance of comet Kohoutek during the SKYLAB operational life-time caused NASA to add comet observation to the mission requirements and to adjust the time when the third crew would man the SKYLAB. The development of new procedures and software for the opportunity to observe this visitor to our solar system is described.

  20. Critical limits for the control points for halal poultry slaughter.

    PubMed

    Shahdan, Intan Azura; Regenstein, Joe Mac; Rahman, Mohammad Tariqur

    2016-12-13

    This study proposes critical limits (CL) for control points for halal slaughter (CPHS). Previously, 6 control points (CP) were determined, and CL for these 6 CPHS are suggested based on: 1) a literature survey for the CL for CP 1 (poultry breeding, rearing, and poultry feed) and CP 2 (welfare of poultry during transportation and lairage); 2) a field survey of slaughter plants in Kuantan (Malaysia) for CP 3 (immobilization), CP 4 (slaughter), CP 5 (time for full bleed-out), and CP 6 (washing and packaging); and 3) controlled experiments to refine the CL for CP 3, 4, and 5. The CL for CP 1 focused on stress reduction during rearing and use of substances that could compromise poultry meat wholesomeness. The CL for CP 2 emphasizes humane best-practices for handling poultry during lairage. The CL for CP 3 suggests a gap of 5 s between 2 shackles if only one shackler is employed and shackling times of <1 min for live chickens. In countries permitting water-bath electrical stunning of halal poultry, the stunning current needed to induce unconsciousness must be defined for the breed and bird size but not cause any chicken deaths. The CL for CP 4 mandates the recitation of the tasmiyah (the invocation), which if done for every chicken, will require ≥5 s between stunning and neck cutting. The CL for CP 4 also includes information about the slaughter knife. In CP 5 the recommended minimum time between neck cutting and scalding is 9.5 min. Finally, the CL for CP 6 emphasizes good supply chain hygiene and zero adulteration from haram species and substances.

  1. Identifying and characterizing major emission point sources as a basis for geospatial distribution of mercury emissions inventories

    NASA Astrophysics Data System (ADS)

    Steenhuisen, Frits; Wilson, Simon J.

    2015-07-01

    Mercury is a global pollutant that poses threats to ecosystem and human health. Due to its global transport, mercury contamination is found in regions of the Earth that are remote from major emissions areas, including the Polar regions. Global anthropogenic emission inventories identify important sectors and industries responsible for emissions at a national level; however, to be useful for air transport modelling, more precise information on the locations of emission is required. This paper describes the methodology applied, and the results of work that was conducted to assign anthropogenic mercury emissions to point sources as part of geospatial mapping of the 2010 global anthropogenic mercury emissions inventory prepared by AMAP/UNEP. Major point-source emission sectors addressed in this work account for about 850 tonnes of the emissions included in the 2010 inventory. This work allocated more than 90% of these emissions to some 4600 identified point source locations, including significantly more point source locations in Africa, Asia, Australia and South America than had been identified during previous work to geospatially-distribute the 2005 global inventory. The results demonstrate the utility and the limitations of using existing, mainly public domain resources to accomplish this work. Assumptions necessary to make use of selected online resources are discussed, as are artefacts that can arise when these assumptions are applied to assign (national-sector) emissions estimates to point sources in various countries and regions. Notwithstanding the limitations of the available information, the value of this procedure over alternative methods commonly used to geo-spatially distribute emissions, such as use of 'proxy' datasets to represent emissions patterns, is illustrated. Improvements in information that would facilitate greater use of these methods in future work to assign emissions to point-sources are discussed. These include improvements to both national

  2. Pointing and tracking control for freedom's Solar Dynamic modules and vibration control of freedom

    NASA Technical Reports Server (NTRS)

    Quinn, Roger D.; Chen, Jiunn-Liang

    1992-01-01

    A control strategy is presented for pointing particular modules of flexible multibody space structures while simultaneously attenuating structural vibrations. The application that is addressed is the planned Space Station Freedom in a growth configuration with Solar Dynamic (SD) module. A NASTRAN model of Freedom is used to demonstrate the control strategy. Two cases of SD concentrator fine-pointing controller bandwidths are studied with examples. The effect of limiting the controller motor torques to realistic baseline values is examined. SD pointing and station vibration control is accomplished during realistic disturbances due to aerodynamic drag, Shuttle docking, and Shuttle reaction control system plume impingement on SD. Gravity gradient induced torques on SD are relatively small and pseudo-steady.

  3. Control-structure interaction in precision pointing servo loops

    NASA Technical Reports Server (NTRS)

    Spanos, John T.

    1989-01-01

    The control-structure interaction problem is addressed via stability analysis of a generic linear servo loop model. With the plant described by the rigid body mode and a single elastic mode, structural flexibility is categorized into one of three types: (1) appendage, (2) in-the-loop minimum phase, and (3) in-the-loop nonminimum phase. Closing the loop with proportional-derivative (PD) control action and introducing sensor roll-off dynamics in the feedback path, stability conditions are obtained. Trade studies are conducted with modal frequency, modal participation, modal damping, loop bandwidth, and sensor bandwidth treated as free parameters. Results indicate that appendage modes are most likely to produce instability if they are near the sensor rolloff, whereas in-the-loop modes are most dangerous near the loop bandwidth. The main goal of this paper is to provide a fundamental understanding of the control-structure interaction problem so that it may benefit the design of complex spacecraft and pointing system servo loops. In this framework, the JPL Pathfinder gimbal pointer is considered as an example.

  4. End point control of an actinide precipitation reactor

    SciTech Connect

    Muske, K.R.; Palmer, M.J.

    1997-10-01

    The actinide precipitation reactors in the nuclear materials processing facility at Los Alamos National Laboratory are used to remove actinides and other heavy metals from the effluent streams generated during the purification of plutonium. These effluent streams consist of hydrochloric acid solutions, ranging from one to five molar in concentration, in which actinides and other metals are dissolved. The actinides present are plutonium and americium. Typical actinide loadings range from one to five grams per liter. The most prevalent heavy metals are iron, chromium, and nickel that are due to stainless steel. Removal of these metals from solution is accomplished by hydroxide precipitation during the neutralization of the effluent. An end point control algorithm for the semi-batch actinide precipitation reactors at Los Alamos National Laboratory is described. The algorithm is based on an equilibrium solubility model of the chemical species in solution. This model is used to predict the amount of base hydroxide necessary to reach the end point of the actinide precipitation reaction. The model parameters are updated by on-line pH measurements.

  5. Developing control points for halal slaughtering of poultry.

    PubMed

    Shahdan, I A; Regenstein, J M; Shahabuddin, A S M; Rahman, M T

    2016-07-01

    Halal (permissible or lawful) poultry meat production must meet industry, economic, and production needs, and government health requirements without compromising the Islamic religious requirements derived from the Qur'an and the Hadiths (the actions and sayings of the Prophet Muhammad, peace and blessings be upon him). Halal certification authorities may vary in their interpretation of these teachings, which leads to differences in halal slaughter requirements. The current study proposes 6 control points (CP) for halal poultry meat production based on the most commonly used halal production systems. CP 1 describes what is allowed and prohibited, such as blood and animal manure, and feed ingredients for halal poultry meat production. CP 2 describes the requirements for humane handling during lairage. CP 3 describes different methods for immobilizing poultry, when immobilization is used, such as water bath stunning. CP 4 describes the importance of intention, details of the halal slaughter, and the equipment permitted. CP 5 and CP 6 describe the requirements after the neck cut has been made such as the time needed before the carcasses can enter the scalding tank, and the potential for meat adulteration with fecal residues and blood. It is important to note that the proposed halal CP program is presented as a starting point for any individual halal certifying body to improve its practices.

  6. Principle and control of a multi-point magnetic inclinometer

    NASA Astrophysics Data System (ADS)

    Gu, Hui-Ping; Zhu, Xian-De; Shen, Gong; Zhang, Jin-Yu; Wang, Yang

    1993-09-01

    In this paper we present a multi-point magnetic inclinometer which is of great value to oil well drilling. When directionfixed drilling is finished, the spatial position of the well must be measured and compared with the design. By using a compass type sensor, the apparatus detects the principal parameters indicating the spatial position of the well axis, inclination and azimuth angles. The angles shown by the angle-measuring system are recorded through photography method. Based on the direction-fixed properties of both the compass and the weight force, design of the sensing part is introduced. The electronic control of the photographic and film feeding system is also described based on the predetermined program.

  7. G proteins: critical control points for transmembrane signals.

    PubMed Central

    Neer, E. J.

    1994-01-01

    Heterotrimeric GTP-binding proteins (G proteins) that are made up of alpha and beta gamma subunits couple many kinds of cell-surface receptors to intracellular effector enzymes or ion channels. Every cell contains several types of receptors, G proteins, and effectors. The specificity with which G protein subunits interact with receptors and effectors defines the range of responses a cell is able to make to an external signal. Thus, the G proteins act as a critical control point that determines whether a signal spreads through several pathways or is focused to a single pathway. In this review, I will summarize some features of the structure and function of mammalian G protein subunits, discuss the role of both alpha and beta gamma subunits in regulation of effectors, the role of the beta gamma subunit in macromolecular assembly, and the mechanisms that might make some responses extremely specific and others rather diffuse. PMID:8142895

  8. Rapid microbiological methods with hazard analysis critical control point.

    PubMed

    Griffiths, M W

    1997-01-01

    The proactive approach to ensuring food safety termed hazard analysis critical control point (HACCP) was introduced in the 1960s by the Pillsbury Company, in collaboration with the U.S. Army Natick Laboratories and National Aeronautics and Space Administration, to help guarantee that astronauts would not be incapacitated by the trauma of foodborne illness during space flights. The approach has subsequently been adopted as the standard food safety management system world-wide and is seen as forming the basis for harmonization of food inspection regulations necessitated by trade agreements such as General Agreement on Tariffs and Trade and North American Free Trade Agreement as the move toward globalization of trade in food products gains momentum. The new U.S. Department of Agriculture Mega-Reg requires mandatory introduction of HACCP, and the Food Safety Enhancement Program of Agriculture and Agri-food Canada, as well as the "due diligence" legislation of the European Union, is centered on HACCP principles.

  9. Sliding control of pointing and tracking with operator spline estimation

    NASA Technical Reports Server (NTRS)

    Dwyer, Thomas A. W., III; Fakhreddine, Karray; Kim, Jinho

    1989-01-01

    It is shown how a variable structure control technique could be implemented to achieve precise pointing and good tracking of a deformable structure subject to fast slewing maneuvers. The correction torque that has to be applied to the structure is based on estimates of upper bounds on the model errors. For a rapid rotation of the deformable structure, the elastic response can be modeled by oscillators driven by angular acceleration, and where stiffness and damping coefficients are also angular velocity and acceleration dependent. By transforming this slew-driven elastic dynamics into bilinear form (be regarding the vector made up of the angular velocity, squared angular velocity and angular acceleration components, which appear in the coefficients as the input to the deformation dynamics), an operator spline can be constructed, that gives a low order estimate of the induced disturbance. Moreover, a worst case error bound between the estimated deformation and the unknown exact deformation is also generated, which can be used where required in the sliding control correction.

  10. MSL EDL Entry Guidance using the Entry Terminal Point Controller

    NASA Technical Reports Server (NTRS)

    2006-01-01

    The Mars Science Laboratory will be the first Mars mission to attempt a guided entry with the objective of safely delivering the entry vehicle to a survivable parachute deploy state within 10 km of the pre-designated landing site. The Entry Terminal Point Controller guidance algorithm is derived from the final phase Apollo Command Module guidance and, like Apollo, modulates the bank angle to control range based on deviations in range, altitude rate, and drag acceleration from a reference trajectory. For application to Mars landers which must make use of the tenuous Martian atmosphere, it is critical to balance the lift of the vehicle to minimize the range while still ensuring a safe deploy altitude. An overview of the process to generate optimized guidance settings is presented, discussing improvements made over the last four years. Performance tradeoffs between ellipse size and deploy altitude will be presented, along with imposed constraints of entry acceleration and heating. Performance sensitivities to the bank reversal deadbands, heading alignment, attitude initialization error, and atmospheric delivery errors are presented. Guidance settings for contingency operations, such as those appropriate for severe dust storm scenarios, are evaluated.

  11. The Galileo scan platform pointing control system - A modern control theoretic viewpoint

    NASA Technical Reports Server (NTRS)

    Sevaston, G. E.; Macala, G. A.; Man, G. K.

    1985-01-01

    The current Galileo scan platform pointing control system (SPPCS) is described, and ways in which modern control concepts could serve to enhance it are considered. Of particular interest are: the multi-variable design model and overall control system architecture, command input filtering, feedback compensator and command input design, stability robustness constraint for both continuous time control systems and for sampled data control systems, and digital implementation of the control system. The proposed approach leads to the design of a system that is similar to current Galileo SPPCS configuration, but promises to be more systematic.

  12. Using bioluminescent biosensors for hazard analysis and critical control point (HACCP) in wastewater control.

    PubMed

    Valat, C; Champiat, D; Degorce-Dumas, J R; Thomas, O

    2004-01-01

    Starting from a new approach for water pollution control and wastewater treatment plant management, the hazard analysis and critical control point (HACCP) quality concept, the interest for the development of new rapid and sensitive methods such as bioluminescence-based methods is evident. After an introduction of the HACCP procedure, a bibliographic study of the bioluminescence potentiality is presented and discussed.

  13. Pointing control system design and performance evaluation of TPF coronagraph

    NASA Astrophysics Data System (ADS)

    Liu, Kuo-Chia; Blaurock, Carl; Mosier, Gary E.

    2004-09-01

    The Terrestrial Planet Finder (TPF) project aims to detect and characterize extra-solar Earth-like planets. The coronagraph telescope is one of the two mission concepts being studied. To reject the star flux and detect the planet flux in the visible light range, the coronagraph telescope must achieve a rejection ratio on the order of a billion to one. Dynamic jitter, introduced by environmental and on-board mechanical disturbances, degrades the optical performance, as characterized primarily by contrast ratio. The feasibility of using passive vibration isolation combined with active attitude and line-of-sight (LOS) control systems to stabilize the spacecraft and the optical components to the requisite level is being studied. The telescope is also required to slew between targets or rotate around the LOS. The slew mode control law must be designed to balance the need for efficient large-angle maneuvers while simultaneously avoiding the excitation of flexible modes in order to minimize settling time. This paper provides an overview of the current control design concept and sensor/actuator topology for TPF Coronagraph and illustrates the fine pointing performance of the telescope. This performance is primarily a function of the rejection of high-frequency dynamic disturbances, in this case due to reaction wheel disturbance forces/torques transmitted through the passive isolation stage. Trade studies between isolator force rejection and disturbance level reduction via wheel redesign are also presented to illustrate the requirements imposed on current technologies. Finally, the paper summarizes preliminary results on the slew/settle performance of the telescope.

  14. Unified approach to control point detection and stereo disparity computation

    NASA Astrophysics Data System (ADS)

    Poelzleitner, Wolfgang; Casasent, David P.

    1996-10-01

    We consider two problems: first, the problem of detection of objects in images of 3D planetary terrain; second, the task of finding corresponding points for stereo matching of this type of images. We propose an approach that is simultaneously applicable to both problem areas. The approach uses a bank of filters based on different 2D Gabor functions. By detection we mean locating multiple classes of targets with distortions present and in a cluttered background. It is desirable to minimize false alarms due to clutter, image noise, and the presence of other objects. In the scenario of stereo matching, the pixel location where we search for the corresponding point is the target, while all ambiguous matches are non-targets. In this work, we use Gabor filter banks in two versions. First, for fast detection of targets, the single filter outputs of the bank are fused by linear combination. Second, for stereo matching, the outputs of the filters form a feature vector used to find the best match. We refer to both types of filters as a macro Gabor filter. In the linear combination case, the filter bank forms a single filter. This filter is correlated with an input image, followed by local maximum detection, and thresholding to yield the finally detected targets. The new aspects are: combining real and imaginary parts of GFs into one filter using centered on off-center GFs, separately optimizing the fusion coefficients of the GFs by controlling the shape of the correlation outputs of each filter alone, and the application to two different scenarios.

  15. A MultiCenter Pilot Randomized Controlled Trial of Remote Ischemic Preconditioning in Major Vascular Surgery.

    PubMed

    Healy, D A; Boyle, E; McCartan, D; Bourke, M; Medani, M; Ferguson, J; Yagoub, H; Bashar, K; O'Donnell, M; Newell, J; Canning, C; McMonagle, M; Dowdall, J; Cross, S; O'Daly, S; Manning, B; Fulton, G; Kavanagh, E G; Burke, P; Grace, P A; Moloney, M Clarke; Walsh, S R

    2015-11-01

    A pilot randomized controlled trial that evaluated the effect of remote ischemic preconditioning (RIPC) on clinical outcomes following major vascular surgery was performed. Eligible patients were those scheduled to undergo open abdominal aortic aneurysm repair, endovascular aortic aneurysm repair, carotid endarterectomy, and lower limb revascularization procedures. Patients were randomized to RIPC or to control groups. The primary outcome was a composite clinical end point comprising any of cardiovascular death, myocardial infarction, new-onset arrhythmia, cardiac arrest, congestive cardiac failure, cerebrovascular accident, renal failure requiring renal replacement therapy, mesenteric ischemia, and urgent cardiac revascularization. Secondary outcomes were components of the primary outcome and myocardial injury as assessed by serum troponin values. The primary outcome occurred in 19 (19.2%) of 99 controls and 14 (14.1%) of 99 RIPC group patients (P = .446). There were no significant differences in secondary outcomes. Our trial generated data that will guide future trials. Further trials are urgently needed. © The Author(s) 2015.

  16. Optimal fine pointing control of a large space telescope using an Annular Momentum Control Device

    NASA Technical Reports Server (NTRS)

    Nadkarni, A. A.; Joshi, S. M.; Groom, N. J.

    1977-01-01

    This paper discusses the application of an Annular Momentum Control Device (AMCD) to fine pointing control of a large space telescope (LST). The AMCD represents a new development in the field of momentum storage devices. A linearized mathematical model is developed for the AMCD/LST system, including the magnetic suspension actuators. Two approaches to control system design are considered. The first approach uses a stochastic linear-quadratic Gaussian controller which utilizes feedback of all states. The second approach considers a more practical control system design in which the axial and radial loops are designed independently.

  17. 49 CFR 236.103 - Switch circuit controller or point detector.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false Switch circuit controller or point detector. 236... Rules and Instructions: All Systems Inspections and Tests; All Systems § 236.103 Switch circuit controller or point detector. Switch circuit controller, circuit controller, or point detector operated...

  18. 49 CFR 236.103 - Switch circuit controller or point detector.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 4 2012-10-01 2012-10-01 false Switch circuit controller or point detector. 236... Rules and Instructions: All Systems Inspections and Tests; All Systems § 236.103 Switch circuit controller or point detector. Switch circuit controller, circuit controller, or point detector operated...

  19. 49 CFR 236.103 - Switch circuit controller or point detector.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Switch circuit controller or point detector. 236... Rules and Instructions: All Systems Inspections and Tests; All Systems § 236.103 Switch circuit controller or point detector. Switch circuit controller, circuit controller, or point detector operated...

  20. 49 CFR 236.103 - Switch circuit controller or point detector.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 4 2013-10-01 2013-10-01 false Switch circuit controller or point detector. 236... Rules and Instructions: All Systems Inspections and Tests; All Systems § 236.103 Switch circuit controller or point detector. Switch circuit controller, circuit controller, or point detector operated...

  1. 49 CFR 236.103 - Switch circuit controller or point detector.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Switch circuit controller or point detector. 236.103 Section 236.103 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL... controller or point detector. Switch circuit controller, circuit controller, or point detector operated by...

  2. [Spatial heterogeneity and classified control of agricultural non-point source pollution in Huaihe River Basin].

    PubMed

    Zhou, Liang; Xu, Jian-Gang; Sun, Dong-Qi; Ni, Tian-Hua

    2013-02-01

    Agricultural non-point source pollution is of importance in river deterioration. Thus identifying and concentrated controlling the key source-areas are the most effective approaches for non-point source pollution control. This study adopts inventory method to analysis four kinds of pollution sources and their emissions intensity of the chemical oxygen demand (COD), total nitrogen (TN), and total phosphorus (TP) in 173 counties (cities, districts) in Huaihe River Basin. The four pollution sources include livestock breeding, rural life, farmland cultivation, aquacultures. The paper mainly addresses identification of non-point polluted sensitivity areas, key pollution sources and its spatial distribution characteristics through cluster, sensitivity evaluation and spatial analysis. A geographic information system (GIS) and SPSS were used to carry out this study. The results show that: the COD, TN and TP emissions of agricultural non-point sources were 206.74 x 10(4) t, 66.49 x 10(4) t, 8.74 x 10(4) t separately in Huaihe River Basin in 2009; the emission intensity were 7.69, 2.47, 0.32 t.hm-2; the proportions of COD, TN, TP emissions were 73%, 24%, 3%. The paper achieves that: the major pollution source of COD, TN and TP was livestock breeding and rural life; the sensitivity areas and priority pollution control areas among the river basin of non-point source pollution are some sub-basins of the upper branches in Huaihe River, such as Shahe River, Yinghe River, Beiru River, Jialu River and Qingyi River; livestock breeding is the key pollution source in the priority pollution control areas. Finally, the paper concludes that pollution type of rural life has the highest pollution contribution rate, while comprehensive pollution is one type which is hard to control.

  3. [Manual trigger point therapy of shoulder pain : Randomized controlled study of effectiveness].

    PubMed

    Sohns, S; Schnieder, K; Licht, G; von Piekartz, H

    2016-12-01

    Although chronic shoulder pain is highly prevalent and myofascial trigger points (mTrP) are thought to be found in the majority of patients with shoulder complaints, the influence on the pain mechanism remains unclear. There are only very few controlled clinical studies on the effects of manual trigger point compression therapy. This randomized controlled trial (RCT) compared the short-term effects of manual trigger point compression therapy (n = 6) with manual sham therapy (n = 6) in patients with unilateral shoulder pain due to myofascial syndrome (MFS). The measurement data were collected before and after two sessions of therapy. Pressure pain thresholds (PPT) of mTrP and symmetrically located points on the asymptomatic side were measured together with neutral points in order to detect a potential unilateral or generalized hyperalgesia. Additionally, the pain was assessed on a visual analog scale (VAS) at rest and during movement and the neck disability index (NDI) and disabilities of the arm, shoulder and hand (DASH) questionnaires were also completed and evaluated. Both treatment modalities led to a significant improvement; however, the manual trigger point compression therapy was significantly more effective in comparison to sham therapy, as measured by different parameters. The significant improvement of PPT values in the interventional group even at sites that were not directly treated, indicates central mechanisms in pain threshold modulation induced by manual compression therapy. The weaker but still measurable effects of sham therapy might be explained by the sham modality being a hands on technique or by sufficient stimulation of the trigger point region during the diagnostics and PPT measurements.

  4. Adaptive Control for Buck Power Converter Using Fixed Point Inducting Control and Zero Average Dynamics Strategies

    NASA Astrophysics Data System (ADS)

    Hoyos Velasco, Fredy Edimer; García, Nicolás Toro; Garcés Gómez, Yeison Alberto

    In this paper, the output voltage of a buck power converter is controlled by means of a quasi-sliding scheme. The Fixed Point Inducting Control (FPIC) technique is used for the control design, based on the Zero Average Dynamics (ZAD) strategy, including load estimation by means of the Least Mean Squares (LMS) method. The control scheme is tested in a Rapid Control Prototyping (RCP) system based on Digital Signal Processing (DSP) for dSPACE platform. The closed loop system shows adequate performance. The experimental and simulation results match. The main contribution of this paper is to introduce the load estimator by means of LMS, to make ZAD and FPIC control feasible in load variation conditions. In addition, comparison results for controlled buck converter with SMC, PID and ZAD-FPIC control techniques are shown.

  5. The impact and control of major southern forest diseases

    Treesearch

    A. Dan Wilson; Theodor D. Leininger; William J. Otrosina; L. David Dwinell; Nathan M. Schiff

    2004-01-01

    A variety of forest health issues, concerns, and events have rapidly changed southern forests and plantations in the past two decades. These factors have strongly impacted the ways we manage forest pests in the Southern United States. This trend will no doubt continue to shape forest pest management in the future. The major issues and events of concern include changing...

  6. Effective variable switching point predictive current control for ac low-voltage drives

    NASA Astrophysics Data System (ADS)

    Stolze, Peter; Karamanakos, Petros; Kennel, Ralph; Manias, Stefanos; Endisch, Christian

    2015-07-01

    This paper presents an effective model predictive current control scheme for induction machines driven by a three-level neutral point clamped inverter, called variable switching point predictive current control. Despite the fact that direct, enumeration-based model predictive control (MPC) strategies are very popular in the field of power electronics due to their numerous advantages such as design simplicity and straightforward implementation procedure, they carry two major drawbacks. These are the increased computational effort and the high ripples on the controlled variables, resulting in a limited applicability of such methods. The high ripples occur because in direct MPC algorithms the actuating variable can only be changed at the beginning of a sampling interval. A possible remedy for this would be to change the applied control input within the sampling interval, and thus to apply it for a shorter time than one sample. However, since such a solution would lead to an additional overhead which is crucial especially for multilevel inverters, a heuristic preselection of the optimal control action is adopted to keep the computational complexity at bay. Experimental results are provided to verify the potential advantages of the proposed strategy.

  7. 21 CFR 120.8 - Hazard Analysis and Critical Control Point (HACCP) plan.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Hazard Analysis and Critical Control Point (HACCP... SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION HAZARD ANALYSIS AND CRITICAL CONTROL POINT (HACCP) SYSTEMS General Provisions § 120.8 Hazard Analysis and Critical Control Point (HACCP) plan. (a) HACCP plan....

  8. Instrument Pointing Control System for the Stellar Interferometry Mission - Planet Quest

    NASA Technical Reports Server (NTRS)

    Brugarolas, Paul B.; Kang, Bryan

    2006-01-01

    This paper describes the high precision Instrument Pointing Control System (PCS) for the Stellar Interferometry Mission (SIM) - Planet Quest. The PCS system provides front-end pointing, compensation for spacecraft motion, and feedforward stabilization, which are needed for proper interference. Optical interferometric measurements require very precise pointing (0.03 as, 1-(sigma) radial) for maximizing the interference pattern visibility. This requirement is achieved by fine pointing control of articulating pointing mirrors with feedback from angle tracking cameras. The overall pointing system design concept is presentcd. Functional requirements and an acquisition concept are given. Guide and Science pointing control loops are discussed. Simulation analyses demonstrate the feasibility of the design.

  9. Articulating the history and major departure points evident in post-apartheid South African national water policy and law

    NASA Astrophysics Data System (ADS)

    Chikozho, C.; Danga, L.; Saruchera, D.

    2017-08-01

    Governance of the water sector in South Africa has reflected the political changes taking place in society. For instance, due to apartheid policies of segregation, inequality of access to water resources marks South Africa's history in a very profound way and redistribution of rights to water to redress the results of past discrimination became an explicit purpose of the post-apartheid water governance policy and legislative regime. In this paper, we articulate the history and major departure points evident in post-apartheid South African national water policy and law. This includes documenting and reflecting on most of the available information that shows how the new water policy and law were developed. Findings from the study show that the key players active in the water law review process deliberately took into account the political goals and dynamics of power asymmetry within which the law was being articulated. Therefore, the water law as it stands today and in the past must be understood within the context of the socio-economic and political landscape that has prevailed in South Africa at different historical junctures. We contend that a detailed examination and articulation of the history and major departure points evident in post-apartheid South African national water policy and law enables practitioners and scholars to better understand the main motivations behind the water sector reforms and the then prevailing thinking behind the policy and legislation eventually promulgated. The present water law must be understood in the context of these reforms and the objectives they sought to achieve.

  10. Pointing and control system design study for the space infrared telescope facility (SIRTF)

    NASA Technical Reports Server (NTRS)

    Lorell, K. R.; Aubrun, J. N.; Sridhar, B.; Cochran, R. W.

    1984-01-01

    The design and performance of pointing and control systems for two space infrared telescope facility vehicles were examined. The need for active compensation of image jitter using the secondary mirror or other optical elements was determined. In addition, a control system to allow the telescope to perform small angle slews, and to accomplish large angle slews at the rate of 15 deg per minute was designed. Both the 98 deg and the 28 deg inclination orbits were examined, and spacecraft designs were developed for each. The results indicate that active optical compensation of line-of-sight errors is not necessary if the system is allowed to settle for roughly ten seconds after a slew maneuver. The results are contingent on the assumption of rigid body dynamics, and a single structural mode between spacecraft and telescope. Helium slosh for a half full 4000 liter tank was analyzed, and did not represent a major control problem.

  11. Preparation of the pointing and control system of the SOFIA Airborne Telescope for early science missions

    NASA Astrophysics Data System (ADS)

    Lampater, Ulrich; Herter, Terry; Keas, Paul; Harms, Franziska; Engfer, Christian; Salewsky, Peter; Jakob, Holger; Roeser, Hans-Peter

    2010-07-01

    During observation flights the telescope structure of the Stratospheric Observatory for Infrared Astronomy (SOFIA) is subject to disturbance excitations over a wide frequency band. The sources can be separated into two groups: inertial excitation caused by vibration of the airborne platform, and aerodynamic excitation that acts on the telescope assembly (TA) through an open port cavity. These disturbance sources constitute a major difference of SOFIA to other ground based and space observatories and achieving the required pointing accuracy of 1 arcsecond cumulative rms or better below 70 Hz in this environment is driving the design of the TA pointing and control system. In the current design it consists of two parts, the rigid body attitude control system and a feed forward based compensator of flexible TA deformation. This paper discusses the characterization and control system tuning of the as-built system. It is a process that integrates the study of the structural dynamic behavior of the TA, the resulting image motion in the focal plane, and the design and implementation of active control systems. Ground tests, which are performed under controlled experimental conditions, and in-flight characterization tests, both leading up to the early science performance capabilities of the observatory, are addressed.

  12. A test of fixed and moving reference point control in posture.

    PubMed

    Lee, I-Chieh; Pacheco, Matheus M; Newell, Karl M

    2017-01-01

    This study investigated two contrasting assumptions of the regulation of posture: namely, fixed and moving reference point control. These assumptions were tested in terms of time-dependent structure and data distribution properties when stability is manipulated. Fifteen male participants performed a tightrope simulated balance task that is, maintaining a tandem stance while holding a pole. Pole length (and mass) and the standing support surface (fixed surface/balance board) were manipulated so as to mechanically change the balance stability. The mean and standard deviation (SD) of COP length were reduced with pole length increment but only in the balance board surface condition. Also, the SampEn was lower with greater pole length for the balance board but not the fixed surface. More than one peak was present in the distribution of COP in the majority of trials. Collectively, the findings provide evidence for a moving reference point in the maintenance of postural stability for quiet standing.

  13. Multi-Interface Point-To-Point Switching System (MIPPSS) Under Unified Control

    DTIC Science & Technology

    1998-09-18

    signaled in a digital circuit by varying voltages. The most common digital logic, transistor-transistor logic ( TTL ), uses +0.5 volts nominal for a low...types of ports, i.e., four Ethernet ports and up to five RS232 ports, advantageously are included in the HUB Controller Cage 23, which is discussed in...one time. The Ethernet and RS232 limits are the maximum number of physical ports of these devices that are available on the HUB Controller. The

  14. Resilience of Greek Youth at an Educational Transition Point: The Role of Locus of Control and Coping Strategies as Resources

    ERIC Educational Resources Information Center

    Leontopoulou, Sophia

    2006-01-01

    Variable--and person--focused approaches were applied to study the resilient outcomes of 326 Greek male and female 1st year university students at a major educational transition point. Results indicated that resilience was related to both cognitive and behavioural psychosocial resources in late adolescence. Locus of control emerged as an important…

  15. Formation Flying With Decentralized Control in Libration Point Orbits

    NASA Technical Reports Server (NTRS)

    Folta, David; Carpenter, J. Russell; Wagner, Christoph

    2000-01-01

    A decentralized control framework is investigated for applicability of formation flying control in libration orbits. The decentralized approach, being non-hierarchical, processes only direct measurement data, in parallel with the other spacecraft. Control is accomplished via linearization about a reference libration orbit with standard control using a Linear Quadratic Regulator (LQR) or the GSFC control algorithm. Both are linearized about the current state estimate as with the extended Kalman filter. Based on this preliminary work, the decentralized approach appears to be feasible for upcoming libration missions using distributed spacecraft.

  16. Major geogenic factors controlling geographical clustering of urolithiasis in China.

    PubMed

    Yang, Yijun; Deng, Yamin; Wang, Yanxin

    2016-11-15

    The prevalence of urolithiasis is increasing across the world and exhibits a distinctive characteristic of geographical distribution. Geographical clustering and major geogenic factors for urolithiasis prevalence in China were investigated. High risks of urolithiasis are found in southern China clustered in coastal provinces such as Fujian and Zhejiang and karst regions such as Sichuan, Chongqing, Guizhou, Guangxi, Guangdong, Hunan, and Hubei. The predominant urinary stone composition is a mixture of calcium oxalate and phosphate. We found that the spatial distribution of phosphate-type stones is closely related to that of phosphate ore deposits and carbonate rocks. Hot or warm climate and seasons increase the risk of lithogenesis through high average air temperature. Water and soil environment influence the quality and composition of drinking water and food, thus affecting stone formation in the urinary system. In particular, the increase of Ca(2+)/Mg(2+) ratio (in meq) in drinking water might be the main factor. Besides, the high content of calcium in local plants grown on karst soils and the intake of high oxalate food might contribute to the high prevalence in South China. This study indicates that urolithiasis could be endemic, with geogenic factors playing critical roles in urolithiasis etiology. Copyright © 2016 Elsevier B.V. All rights reserved.

  17. Domain-specific impairment in cognitive control among remitted youth with a history of major depression.

    PubMed

    Peters, Amy T; Jacobs, Rachel H; Crane, Natania A; Ryan, Kelly A; Weisenbach, Sara L; Ajilore, Olusola; Lamar, Melissa; Kassel, Michelle T; Gabriel, Laura B; West, Amy E; Zubieta, Jon-Kar; Langenecker, Scott A

    2017-10-01

    Impairment in neuropsychological functioning is common in major depressive disorder (MDD), but it is not clear to what degree these deficits are related to risk (e.g. trait), scar, burden or state effects of MDD. The objective of this study was to use neuropsychological measures, with factor scores in verbal fluency, processing speed, attention, set-shifting and cognitive control in a unique population of young, remitted, unmedicated, early course individuals with a history of MDD in hopes of identifying putative trait markers of MDD. Youth aged 18-23 in remission from MDD (rMDD; n = 62) and healthy controls (HC; n = 43) were assessed with neuropsychological tests at two time points. These were from four domains of executive functioning, consistent with previous literature as impaired in MDD: verbal fluency and processing speed, conceptual reasoning and set-shifting, processing speed with interference resolution, and cognitive control. rMDD youth performed comparably to HCs on verbal fluency and processing speed, processing speed with interference resolution, and conceptual reasoning and set-shifting, reliably over time. Individuals with rMDD demonstrated relative decrements in cognitive control at Time 1, with greater stability than HC participants. MDD may be characterized by regulatory difficulties that do not pertain specifically to active mood state or fluctuations in symptoms. Deficient cognitive control may represent a trait vulnerability or early course scar of MDD that may prove a viable target for secondary prevention or early remediation. © 2015 Wiley Publishing Asia Pty Ltd.

  18. Nutritional anaemia — a major controllable public health problem

    PubMed Central

    Baker, S. J.

    1978-01-01

    Nutritional anaemia, due chiefly to iron deficiency, is widely prevalent in many parts of the world. There is increasing evidence that even mild anaemia affects health and reduces productivity and that a high prevalence of anaemia has profound socioeconomic consequences. The pathogenesis of nutritional anaemia is now reasonably well understood. Measures avilable for combating it include: therapeutic supplementation for accessible population groups with a high prevalence of anaemia, such as pregnant women and schoolchildren; iron fortification of one or more widely consumed foodstuffs; management of those conditions, such as hookworm infestation, that increase requirements for haemopoietic nutrients; and education of the public, and of all categories of health personnel, regarding the importance of anaemia and the ways of controlling it. Experience has shown that there is no simple solution to the problem and in each area where iron deficiency anaemia is prevalent it will probably be necessary to develop and combine many or all of these measures. In each community it will be necessary to introduce these measures so that their effectiveness can first be studied in a pilot trial. When this has been successfully completed it should be followed by a field trial under realistic conditions, and only when this has proved successful should a regional or national programme be introduced. However, the problem is complex and it is only by sustained effort of all concerned that it will prove possible to develop adequate public health control of nutritional anaemia. PMID:310714

  19. Ground control to major TOM: mitochondria-nucleus communication.

    PubMed

    Eisenberg-Bord, Michal; Schuldiner, Maya

    2017-01-01

    Mitochondria have crucial functions in the cell, including ATP generation, iron-sulfur cluster biogenesis, nucleotide biosynthesis, and amino acid metabolism. All of these functions require tight regulation on mitochondrial activity and homeostasis. As mitochondria biogenesis is controlled by the nucleus and almost all mitochondrial proteins are encoded by nuclear genes, a tight communication network between mitochondria and the nucleus has evolved, which includes signaling cascades, proteins which are dual-localized to the two compartments, and sensing of mitochondrial products by nuclear proteins. All of these enable a crosstalk between mitochondria and the nucleus that allows the 'ground control' to get information on mitochondria's status. Such information facilitates the creation of a cellular balance of mitochondrial status with energetic needs. This communication also allows a transcriptional response in case mitochondrial function is impaired aimed to restore mitochondrial homeostasis. As mitochondrial dysfunction is related to a growing number of genetic diseases as well as neurodegenerative conditions and aging, elucidating the mechanisms governing the mitochondrial/nuclear communication should progress a better understanding of mitochondrial dysfunctions. © 2016 Federation of European Biochemical Societies.

  20. Major enzymes controlling the androgenic pressure in the developing lung.

    PubMed

    Tremblay, Yves; Provost, Pierre R

    2013-09-01

    A sex difference is observed in the incidence and morbidity of respiratory distress syndrome (RDS) of the neonate and in bronchopulmonary dysplasia (BPD). The involvement of androgens is well evidenced in RDS and it is suspected in BPD. Interestingly, the developing lung is not an inert tissue just exposed to circulating androgens, but is rather an active androgen metabolizing tissue, expressing enzymes involved in both androgen synthesis and inactivation. The present review focuses on the major enzymes involved in androgen metabolism within the developing lung. Testosterone synthesis and inactivation by AKR1C3/Akr1c6 (human/mouse 17β-hydroxysteroid dehydrogenases (HSDs) type 5) and HSD17B2 (17β-HSD type 2), respectively, play an important role in the developing lung. Akr1c14 (3α-HSD) shows a strong increase in expression according to developmental time. The canalicular stage of lung development corresponding to the surge of surfactant lipid synthesis, which is linked to RDS, as well as saccularization/alveolarization, which are linked to BPD, are covered by this review for the mouse and human species. The androgen metabolizing enzymes expressed within the developing lung can become potential pharmaceutical targets in the objective of accelerating lung maturation by specific treatments. The classic deleterious effects of androgens on lung maturation and the surge of surfactant synthesis in males are well known. Conversely, androgens also have positive impacts on the development of both male and female lungs. Steroidogenic enzymes are key regulators of these positive effects. This article is part of a Special Issue entitled 'CSR 2013'.

  1. Upstream Pathways Controlling Mitochondrial Function in Major Psychosis

    PubMed Central

    Machado, Alencar Kolinski; Pan, Alexander Yongshuai; da Silva, Tatiane Morgana; Duong, Angela

    2016-01-01

    Mitochondrial dysfunction is commonly observed in bipolar disorder (BD) and schizophrenia (SCZ) and may be a central feature of psychosis. These illnesses are complex and heterogeneous, which is reflected by the complexity of the processes regulating mitochondrial function. Mitochondria are typically associated with energy production; however, dysfunction of mitochondria affects not only energy production but also vital cellular processes, including the formation of reactive oxygen species, cell cycle and survival, intracellular Ca2+ homeostasis, and neurotransmission. In this review, we characterize the upstream components controlling mitochondrial function, including 1) mutations in nuclear and mitochondrial DNA, 2) mitochondrial dynamics, and 3) intracellular Ca2+ homeostasis. Characterizing and understanding the upstream factors that regulate mitochondrial function is essential to understand progression of these illnesses and develop biomarkers and therapeutics. PMID:27310240

  2. Global stabilization of fixed points using predictive control

    NASA Astrophysics Data System (ADS)

    Liz, Eduardo; Franco, Daniel

    2010-06-01

    We analyze the global stability properties of some methods of predictive control. We particularly focus on the optimal control function introduced by de Sousa Vieira and Lichtenberg [Phys. Rev. E 54, 1200 (1996)]. We rigorously prove that it is possible to use this method for the global stabilization of a discrete system xn +1=f(xn) into a positive equilibrium for a class of maps commonly used in population dynamics. Moreover, the controlled system is globally stable for all values of the control parameter for which it is locally asymptotically stable. Our study highlights the difficulty of obtaining global stability results for other methods of predictive control, where higher iterations of f are used in the control scheme.

  3. Autonomous-Control Concept For Instrument Pointing System

    NASA Technical Reports Server (NTRS)

    Mettler, Edward; Milman, Mark H.; Bayard, David S.

    1990-01-01

    Integrated payload articulation and identification system (IPAIDS) is conceptual system to control aiming of instruments aboard spacecraft of proposed Earth Observation System (EOS). Principal features of concept include advanced control strategies intended to assure robustness of performance over wide range of uncertainties in characteristics of spacecraft and instrument system. Intended originally for application to spacecraft system, has potential utility on Earth for automatic control of autonomous (robotic) vehicles or of remote sensing systems.

  4. Towards a controlled study of the QCD critical point

    NASA Astrophysics Data System (ADS)

    de Forcrand, Ph; Philipsen, O.

    2008-10-01

    The phase diagram of QCD, as a function of temperature T and quark chemical potential μ, may contain a critical point (μE, TE) whose non-perturbative nature makes it a natural object of lattice studies. However, the sign problem prevents the application of standard Monte Carlo techniques at nonzero baryon density. We have been pursuing an approach free of the sign problem, where the chemical potential is taken as imaginary and the results are Taylor expanded in μ/T about μ = 0, then analytically continued to real μ. Within this approach we have determined the sensitivity of the critical chemical potential μE to the quark mass, d(\\mu_E)^2/dm_q|_{\\mu_E=0} . Our study indicates that the critical point moves to a larger chemical potential as the quark mass decreases. This finding, contrary to common wisdom, implies that the deconfinement crossover, which takes place in QCD at μ = 0 when the temperature is raised, will remain a crossover in the μ-region where our Taylor expansion can be trusted. If this result, obtained on a coarse lattice, is confirmed by simulations on finer lattices now in progress, then we predict that no chiral critical point will be found for μB lsim 500 MeV, unless the phase diagram contains additional transitions.

  5. Digital controller design: Analysis of the annular suspension pointing system. [analog controllers with feedback

    NASA Technical Reports Server (NTRS)

    Kuo, B. C.

    1978-01-01

    The analog controllers of the annular suspension pointing system are designed for control of the chi, phi sub 1, and phi sub 2 bandwidth dynamics through decoupling and pole placement. Since it is virtually impossible to find an equivalent bandwidth of the overall system and establish a general eigenvalue requirement for the system, the subsystem dynamics are decoupled through state feedback and the poles are placed simultaneously to realize the desired bandwidths for the three system components. Decoupling and pole placement are also used to design the closed-loop digital system through approximation.

  6. 49 CFR 236.303 - Control circuits for signals, selection through circuit controller operated by switch points or...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...-point frogs and derails shall be selected through circuit controller operated directly by switch points... switch, movable-point frog, and derail in the routes governed by such signal. Circuits shall be arranged... when each switch, movable-point frog, and derail in the route is in proper position. ...

  7. 49 CFR 236.303 - Control circuits for signals, selection through circuit controller operated by switch points or...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...-point frogs and derails shall be selected through circuit controller operated directly by switch points... switch, movable-point frog, and derail in the routes governed by such signal. Circuits shall be arranged... when each switch, movable-point frog, and derail in the route is in proper position. ...

  8. 49 CFR 236.303 - Control circuits for signals, selection through circuit controller operated by switch points or...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...-point frogs and derails shall be selected through circuit controller operated directly by switch points... switch, movable-point frog, and derail in the routes governed by such signal. Circuits shall be arranged... when each switch, movable-point frog, and derail in the route is in proper position. ...

  9. 49 CFR 236.303 - Control circuits for signals, selection through circuit controller operated by switch points or...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...-point frogs and derails shall be selected through circuit controller operated directly by switch points... switch, movable-point frog, and derail in the routes governed by such signal. Circuits shall be arranged... when each switch, movable-point frog, and derail in the route is in proper position. ...

  10. 49 CFR 236.303 - Control circuits for signals, selection through circuit controller operated by switch points or...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...-point frogs and derails shall be selected through circuit controller operated directly by switch points... switch, movable-point frog, and derail in the routes governed by such signal. Circuits shall be arranged... when each switch, movable-point frog, and derail in the route is in proper position. ...

  11. Entry Point Depth and Online Search Using a Controlled Vocabulary.

    ERIC Educational Resources Information Center

    Boyce, Bert R.; McLain, John P.

    1989-01-01

    Discusses previous research that examined the effects of different kinds of vocabulary control on retrieval effectiveness, and describes a study that addressed the effects of indexing depth on standard retrieval evaluation measures in the context of a typical commercial retrieval system. It is concluded that controlled vocabularies affect…

  12. Anatomy of an experimental two-link flexible manipulator under end-point control

    NASA Technical Reports Server (NTRS)

    Oakley, Celia M.; Cannon, Robert H., Jr.

    1990-01-01

    The design and experimental implementation of an end-point controller for two-link flexible manipulators are presented. The end-point controller is based on linear quadratic Gaussian (LQG) theory and is shown to exhibit significant improvements in trajectory tracking over a conventional controller design. To understand the behavior of the manipulator structure under end-point control, a strobe sequence illustrating the link deflections during a typical slew maneuver is included.

  13. Anatomy of an experimental two-link flexible manipulator under end-point control

    NASA Technical Reports Server (NTRS)

    Oakley, Celia M.; Cannon, Robert H., Jr.

    1990-01-01

    The design and experimental implementation of an end-point controller for two-link flexible manipulators are presented. The end-point controller is based on linear quadratic Gaussian (LQG) theory and is shown to exhibit significant improvements in trajectory tracking over a conventional controller design. To understand the behavior of the manipulator structure under end-point control, a strobe sequence illustrating the link deflections during a typical slew maneuver is included.

  14. Major safety and operational concerns for fuel debris criticality control

    SciTech Connect

    Tonoike, K.; Sono, H.; Umeda, M.; Yamane, Y.; Kugo, T.; Suyama, K.

    2013-07-01

    It can be seen from the criticality control viewpoint that the requirement divides the decommissioning work into two parts. One is the present condition where it is requested to prevent criticality and to monitor subcritical condition while the debris is untouched. The other is future work where the subcritical condition shall be ensured even if the debris condition is changed intentionally by raising water level, debris retrieval, etc. Repair of damages on the containment vessel (CV) walls is one of the most important objectives at present in the site. On completion of this task, it will become possible to raise water levels in the CVs and to shield the extremely high radiation emitted from the debris but there is a dilemma: raising the water level in the CVs implies to bring the debris closer to criticality because of the role of water for slowing down neutrons. This may be solved if the coolant water will start circulating in closed loops, and if a sufficient concentration of soluble neutron poison (borated water for instance) will be introduced in the loop. It should be still noted that this solution has a risk of worsening corrosion of the CV walls. Design of the retrieval operation of debris should be proposed as early as possible, which must include a neutron poison concentration required to ensure that the debris chunk is subcritical. In parallel, the development of the measurement system to monitor subcritical condition of the debris chunk should be conducted in case the borated water cannot be used continuously. The system would be based on a neutron counter with a high sensitivity and an appropriate shield for gamma-rays, and the adequate statistical signal processing.

  15. Metrology sensor characterization and pointing control for the Formation Interferometer Testbed (FIT)

    NASA Technical Reports Server (NTRS)

    Shields, J.; Sirlin, S.; Wette, M.

    2001-01-01

    In this paper, the metrology pointing sensor of the Starlight ground instrument prototype is characterized and a siderostat pointing control loop is closed between two optical benches with a 10 meter separation.

  16. a Libration Model for Enceladus Based on Geodetic Control Point Network Analysis

    NASA Astrophysics Data System (ADS)

    Nadezhdina, I. E.; Zubarev, A. E.; Brusnikin, E. S.; Oberst, J.

    2016-06-01

    A new global control point network was derived for Enceladus, based on Cassini and Voyager-2 image data. Cassini images were taken from 2005 to 2014, for Voyager we have only one flyby in the middle of 1981. We have derived 3D Cartesian coordinates for 1128 control points as well as improved pointing data for 12 Voyager and 193 Cassini images in the Enceladus-fixed coordinate system. The point accuracies vary from 55 m to 2900 m (average point accuracy - 221 m). From tracking of the control points we detect a librational motion described by a model which includes 3 different periods and amplitudes (Rambaux et al., 2011). We determine the amplitudes for each term. Our new control point network has a higher number of point measurements and a higher accuracy than previous data (Giese et al., 2014).

  17. Stability analysis of fixed points via chaos control.

    PubMed

    Locher, M.; Johnson, G. A.; Hunt, E. R.

    1997-12-01

    This paper reviews recent advances in the application of chaos control techniques to the stability analysis of two-dimensional dynamical systems. We demonstrate how the system's response to one or multiple feedback controllers can be utilized to calculate the characteristic multipliers associated with an unstable periodic orbit. The experimental results, obtained for a single and two coupled diode resonators, agree well with the presented theory. (c) 1997 American Institute of Physics.

  18. Pointing and control system performance and improvement strategies for the SOFIA Airborne Telescope

    NASA Astrophysics Data System (ADS)

    Graf, Friederike; Reinacher, Andreas; Jakob, Holger; Lampater, Ulrich; Pfueller, Enrico; Wiedemann, Manuel; Wolf, Jürgen; Fasoulas, Stefanos

    2016-07-01

    The Stratospheric Observatory for Infrared Astronomy (SOFIA) has already successfully conducted over 300 flights. In its early science phase, SOFIA's pointing requirements and especially the image jitter requirements of less than 1 arcsec rms have driven the design of the control system. Since the first observation flights, the image jitter has been gradually reduced by various control mechanisms. During smooth flight conditions, the current pointing and control system allows us to achieve the standards set for early science on SOFIA. However, the increasing demands on the image size require an image jitter of less than 0.4 arcsec rms during light turbulence to reach SOFIA's scientific goals. The major portion of the remaining image motion is caused by deformation and excitation of the telescope structure in a wide range of frequencies due to aircraft motion and aerodynamic and aeroacoustic effects. Therefore the so-called Flexible Body Compensation system (FBC) is used, a set of fixed-gain filters to counteract the structural bending and deformation. Thorough testing of the current system under various flight conditions has revealed a variety of opportunities for further improvements. The currently applied filters have solely been developed based on a FEM analysis. By implementing the inflight measurements in a simulation and optimization, an improved fixed-gain compensation method was identified. This paper will discuss promising results from various jitter measurements recorded with sampling frequencies of up to 400 Hz using the fast imaging tracking camera.

  19. The Validity of the SAT® for Predicting Cumulative Grade Point Average by College Major. Research Report 2012-6

    ERIC Educational Resources Information Center

    Shaw, Emily J.; Kobrin, Jennifer L.; Patterson, Brian F.; Mattern, Krista D.

    2012-01-01

    The current study examined the differential validity of the SAT for predicting cumulative GPA (cGPA) through the second year of college by college major, as well as the differential prediction of cGPA by college major across student subgroups. The relationship between the SAT and cGPA varied somewhat by major, as well as by major and subgroup…

  20. Controlled-release fertilizer (CRF): a green fertilizer for controlling non-point contamination in agriculture.

    PubMed

    Mao, Xiao-yun; Sun, Ke-jun; Wang, De-han; Liao, Zong-wen

    2005-01-01

    Fertilizers contribute greatly to high yields but also result in environmental non-point contamination, including the emission of greenhouse gas (N2O) and eutrophication of water bodies. How to solve this problem has become a serious challenge, especially for China as its high ecological pressure. Controlled-release fertilizer(CRF) has been developed to minimize the contamination while keeping high yield and has become a green fertilizer for agriculture. Several CRFs made with special coating technology were used for testing the fertilizer effects in yield and environment through pot experiment and field trial. The result indicated that the CRFs had higher N use efficiency, thus reducing N loss through leaching and volatilization while keeping higher yields. Comparing with imported standard CRFs, the test on CRFs showed similar fertilizer effect but with much lower cost. CRFs application is becoming a new approach for minimizing non-point contamination in agriculture.

  1. 21 CFR 120.8 - Hazard Analysis and Critical Control Point (HACCP) plan.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... General Provisions § 120.8 Hazard Analysis and Critical Control Point (HACCP) plan. (a) HACCP plan. Each.... Sanitation controls may be included in the HACCP plan. However, to the extent that they are monitored in... 21 Food and Drugs 2 2011-04-01 2011-04-01 false Hazard Analysis and Critical Control Point...

  2. 47 CFR 90.463 - Transmitter control points.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... transmitter or transmitters controlled are either radiating “RF” energy, or when the transmitter circuits have... meter may be employed to indicate the activation of both the local and the remote transmitter(s). (2) To... operator to determine when they are radiating “RF” energy or when the transmitter circuits have been placed...

  3. 47 CFR 90.463 - Transmitter control points.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... transmitter or transmitters controlled are either radiating “RF” energy, or when the transmitter circuits have... meter may be employed to indicate the activation of both the local and the remote transmitter(s). (2) To... operator to determine when they are radiating “RF” energy or when the transmitter circuits have been placed...

  4. 47 CFR 90.463 - Transmitter control points.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... transmitter or transmitters controlled are either radiating “RF” energy, or when the transmitter circuits have... meter may be employed to indicate the activation of both the local and the remote transmitter(s). (2) To... operator to determine when they are radiating “RF” energy or when the transmitter circuits have been placed...

  5. The Anopheles gambiae transcriptome - a turning point for malaria control.

    PubMed

    Domingos, A; Pinheiro-Silva, R; Couto, J; do Rosário, V; de la Fuente, J

    2017-04-01

    Mosquitoes are important vectors of several pathogens and thereby contribute to the spread of diseases, with social, economic and public health impacts. Amongst the approximately 450 species of Anopheles, about 60 are recognized as vectors of human malaria, the most important parasitic disease. In Africa, Anopheles gambiae is the main malaria vector mosquito. Current malaria control strategies are largely focused on drugs and vector control measures such as insecticides and bed-nets. Improvement of current, and the development of new, mosquito-targeted malaria control methods rely on a better understanding of mosquito vector biology. An organism's transcriptome is a reflection of its physiological state and transcriptomic analyses of different conditions that are relevant to mosquito vector competence can therefore yield important information. Transcriptomic analyses have contributed significant information on processes such as blood-feeding parasite-vector interaction, insecticide resistance, and tissue- and stage-specific gene regulation, thereby facilitating the path towards the development of new malaria control methods. Here, we discuss the main applications of transcriptomic analyses in An. gambiae that have led to a better understanding of mosquito vector competence.

  6. Fixed-point vs. floating-point arithmetic comparison for adaptive optics real-time control computation

    NASA Astrophysics Data System (ADS)

    Martín-Hernando, Yolanda; Rodríguez-Ramos, Luis F.; Garcia-Talavera, Marcos R.

    2008-07-01

    Most computers in the past have been equipped with floating point processing capabilities, allowing an easy and brute-force solution for the machine computation errors, not requiring any specific tailoring of the computation in nearly hundred percent of situations. However, the computation needed for the adaptive optics real-time control in 30-50 meter telescopes is big enough to cause trouble to conventional von-Neumann processors, even if Moore's Law is valid for the next years. Field Programmable Gate Array (FPGAs) have been proposed as a viable alternative to cope with such computation needs[1,2], but--at least today's chips--will require fixed-point arithmetic to be used instead. It is then important to evaluate up to what point the accuracy and stability of the control system will be affected by this limitation. This paper presents the simulation and laboratory results of the comparison between both arithmetics, specifically evaluated in an adaptive optics system. The real-time controller has been modeled as black box having as input the wavefront sensor camera digital output data, providing a digital output to the actuators of the deformable mirror, and with the task of internally computing all outputs from the inputs. MATLAB fixed-point library has been used to evaluate the effect of different precision lengths (5-10 fractional bits) in the computation of the Shack-Hartmann subaperture centroid, in comparison with the reference 64-bit floating-point arithmetic and with the noise floor of the real system, concluding that the effect of the limited precision can be overcome by adequately selecting the number of fractional bits used in the representation, and tailoring that number with the needs at every step of the algorithm.

  7. [Spatial discharge characteristics and total load control of non-point source pollutants based on the catchment scale].

    PubMed

    Wang, Xia-Hui; Lu, Jun; Zhang, Qing-Zhong; Wang, Bo; Yao, Rui-Hua; Zhang, Hui-Yuan; Huang, Feng

    2011-09-01

    Agricultural non-point source pollution is one of the major causes of water quality deterioration. Based on the analysis of the spatial discharge characteristics and intensity of major pollutants from the agricultural pollution source, the establishment of spatial management subzones for controlling agricultural non-point pollution and a design of a plan for total load control of pollutants from each subzone is an important way to improve the efficiency of control measures. In this paper the Four Lake basin in Hubei Province is adopted as the research case region and a systematic research of the control countermeasures of agricultural non-point pollution based on the catchment scale is carried out. The results shows that in the Four Lake basin, the COD, total nitrogen, total phosphorus and ammonia nitrogen load of the water environment are mainly caused by agricultural non-point pollution. These four kinds of non-point source pollutants respectively account for 67.6%, 82.2%, 84.7% and 50.9% of the total pollutant discharge amount in the basin. The analysis of the spatial discharge characteristics of non-point source pollutants in the Four Lake basin shows that the major contributor source regions of non-point source pollutant in the basin are the four counties, including Honghu, Jianli, Qianjiang and Shayang where the aquatic and livestock production are relatively developed. According to the spatial discharge characteristics of the pollutants and the evaluation of the discharge intensity of pollutants, the Four Lake basin is divided into three agricultural non-point pollution management subzones, which including Changhu upstream aquatic and livestock production pollution control subzone, Four-lake trunk canal rural non-point source pollution control subzone and Honghu aquatic production pollution control subzone. Specific pollution control measures are put forward for each subzone. With a comprehensive consideration of the water quality amelioration and the

  8. Escitalopram versus paroxetine controlled release in major depressive disorder: a randomized trial

    PubMed Central

    Kishi, Taro; Matsuda, Yuki; Matsunaga, Shinji; Moriwaki, Masatsugu; Otake, Yoichiro; Akamatsu, Kaku; Okochi, Tomo; Hirano, Shigeki; Funahashi, Toshihiko; Okuda, Momoko; Tabuse, Hideaki; Fujita, Kiyoshi; Iwata, Nakao

    2017-01-01

    Objective There are no direct comparisons between escitalopram and paroxetine controlled release in patients with major depressive disorder (MDD). Methods We conducted a 24-week, rater-masked, randomized trial of escitalopram (5–20 mg/day) versus paroxetine controlled release (12.5–50 mg/day) in patients with MDD (UMIN000011191). Patients with the diagnosis of moderate-to-severe MDD (a 17-item Hamilton Rating Scale for Depression [HAMD-17], with total score at baseline being ≥20) were recruited to participate in a parallel, randomized, controlled trial. The primary outcome for efficacy was an improvement in the 21-item HAMD (HAMD-21) total score at 24 weeks. The secondary outcomes were the response, remission, and discontinuation rates and the incidence of individual adverse events. Results A total of 88 patients with MDD (males, 61.4%; mean age, 40.8±13.4 years) were recruited. The discontinuation rate was 58.0% (escitalopram, 55.8%; paroxetine controlled release, 60.0%). Both escitalopram and paroxetine controlled-release treatment groups exhibited significant reduction in the HAMD-21 total score at 2, 4, 8, 12, and 24 weeks from the baseline. However, there were no significant differences in the HAMD-21 total score, response rate, remission rate, and discontinuation rate at any time point between the groups. In addition, there were no significant differences in the incidence of any individual adverse events (eg, nausea, vomiting, and somnolence) between the treatment groups. Conclusion Our results suggest that escitalopram and paroxetine controlled release had similar efficacy and safety profiles in patients with MDD. One of the primary limitations of this study is the small sample size. PMID:28123299

  9. Pointing Control System Design and Performance Evaluation for TPF Coronagraph

    NASA Technical Reports Server (NTRS)

    Liu, Kuo-Chia; Blaurock, Carl; Mosier, Gary

    2004-01-01

    The Terrestrial Planet Finder (TPF) program aims to detect and characterize extra-solar Earth-like planets. The coronagraph telescope is one of the four mission concepts being studied. In order to reject the star flux and detect the planet flux in the visible light range, the coronagraph telescope must achieve a rejection ratio on the order of a billion to one. Dynamic jitter, introduced by environmental and on-board mechanical disturbances, degrades the optical performance, as characterized primarily by contrast ratio. The feasibility of using passive vibration isolation combined with active attitude and line-of- sight control systems to stabilize the spacecraft and the optical components to the requisite level is being studied. The telescope is also required to slew between targets. The slew mode control law must be designed to balance the need for efficient large-angle maneuvers while simultaneously avoiding the excitation of flexible modes in order to minimize settling time.

  10. Hypophosphatemic rickets: revealing novel control points for phosphate homeostasis.

    PubMed

    White, Kenneth E; Hum, Julia M; Econs, Michael J

    2014-09-01

    Rapid and somewhat surprising advances have recently been made toward understanding the molecular mechanisms causing heritable disorders of hypophosphatemia. The results of clinical, genetic, and translational studies have interwoven novel concepts underlying the endocrine control of phosphate metabolism, with far-reaching implications for treatment of both rare Mendelian diseases as well as common disorders of blood phosphate excess such as chronic kidney disease (CKD). In particular, diseases caused by changes in the expression and proteolytic control of the phosphaturic hormone fibroblast growth factor-23 (FGF23) have come to the forefront in terms of directing new models explaining mineral metabolism. These hypophosphatemic disorders as well as others resulting from independent defects in phosphate transport or metabolism will be reviewed herein, and implications for emerging therapeutic strategies based upon these new findings will be discussed.

  11. Pointing Control System Design and Performance Evaluation for TPF Coronagraph

    NASA Technical Reports Server (NTRS)

    Liu, Kuo-Chia; Blaurock, Carl; Mosier, Gary

    2004-01-01

    The Terrestrial Planet Finder (TPF) program aims to detect and characterize extra-solar Earth-like planets. The coronagraph telescope is one of the four mission concepts being studied. In order to reject the star flux and detect the planet flux in the visible light range, the coronagraph telescope must achieve a rejection ratio on the order of a billion to one. Dynamic jitter, introduced by environmental and on-board mechanical disturbances, degrades the optical performance, as characterized primarily by contrast ratio. The feasibility of using passive vibration isolation combined with active attitude and line-of- sight control systems to stabilize the spacecraft and the optical components to the requisite level is being studied. The telescope is also required to slew between targets. The slew mode control law must be designed to balance the need for efficient large-angle maneuvers while simultaneously avoiding the excitation of flexible modes in order to minimize settling time.

  12. [The key points of Chinese children myopia prevention and control].

    PubMed

    Chu, Renyuan

    2014-01-01

    With the development of information technology and urbanization, the prevalence of myopia in Chinese children is rising each year, meanwhile, there appears to be some cognitive and behavioral misunderstanding about the prevention and treatment of myopia now. To control the development of myopia, we should make efforts to focus on prevention of myopia, promote scientific ways of diagnosis and treatment, as well as implement integrated project.

  13. Pointing and control system enabling technology for future automated space missions

    NASA Technical Reports Server (NTRS)

    Dahlgren, J. B.

    1978-01-01

    Future automated space missions present challenging opportunities in the pointing-and-control technology disciplines. The enabling pointing-and-control system technologies for missions from 1985 to the year 2000 were identified and assessed. A generic mission set including Earth orbiter, planetary, and other missions which predominantly drive the pointing-and-control requirements was selected for detailed evaluation. Technology candidates identified were prioritized as planning options for future NASA-OAST advanced development programs. The primary technology thrusts in each candidate program were cited, and advanced development programs in pointing-and-control were recommended for the FY 80 to FY 87 period, based on these technology thrusts.

  14. [An Analysis of El Camino College Students According to Their Majors, Perceptions of Academic Relevancy, and Unit and Grade Point Characteristics.

    ERIC Educational Resources Information Center

    Garlock, Jerry

    These three separate studies of students at El Camino College (California) discuss their majors, perceptions of academic relevancy, and grade point characteristics. Sub-groups of students (freshman/sophomore, full-time/part-time) are compared according to their major divisions (physical sciences, fine arts, natural sciences, etc.) and also…

  15. Earth observing system instrument pointing control modeling for polar orbiting platforms

    NASA Technical Reports Server (NTRS)

    Briggs, H. C.; Kia, T.; Mccabe, S. A.; Bell, C. E.

    1987-01-01

    An approach to instrument pointing control performance assessment for large multi-instrument platforms is described. First, instrument pointing requirements and reference platform control systems for the Eos Polar Platforms are reviewed. Performance modeling tools including NASTRAN models of two large platforms, a modal selection procedure utilizing a balanced realization method, and reduced order platform models with core and instrument pointing control loops added are then described. Time history simulations of instrument pointing and stability performance in response to commanded slewing of adjacent instruments demonstrates the limits of tolerable slew activity. Simplified models of rigid body responses are also developed for comparison. Instrument pointing control methods required in addition to the core platform control system to meet instrument pointing requirements are considered.

  16. Attitude control concepts for precision-pointing nonrigid spacecraft

    NASA Technical Reports Server (NTRS)

    Likins, P. W.

    1974-01-01

    Literal criteria are developed for the controllability and observability of general models of flexible spacecraft. Results are interpreted in special cases and in physical terms, permitting in some cases the identification of uncontrollable and unobservable states simply by examination of scalars composed of modal parameters and location matrices for sensors and actuators. A procedure is established for isolation of uncontrollable states, whereby sensor and actuator configurations assure that uncontrollable flexible mode states are also unobservable; in many applications such states can then be removed by coordinate truncation.

  17. Syndecan-4 Phosphorylation Is a Control Point for Integrin Recycling

    PubMed Central

    Morgan, Mark R.; Hamidi, Hellyeh; Bass, Mark D.; Warwood, Stacey; Ballestrem, Christoph; Humphries, Martin J.

    2013-01-01

    Summary Precise spatiotemporal coordination of integrin adhesion complex dynamics is essential for efficient cell migration. For cells adherent to fibronectin, differential engagement of α5β1 and αVβ3 integrins is used to elicit changes in adhesion complex stability, mechanosensation, matrix assembly, and migration, but the mechanisms responsible for receptor regulation have remained largely obscure. We identify phosphorylation of the membrane-intercalated proteoglycan syndecan-4 as an essential switch controlling integrin recycling. Src phosphorylates syndecan-4 and, by driving syntenin binding, leads to suppression of Arf6 activity and recycling of αVβ3 to the plasma membrane at the expense of α5β1. The resultant elevation in αVβ3 engagement promotes stabilization of focal adhesions. Conversely, abrogation of syndecan-4 phosphorylation drives surface expression of α5β1, destabilizes adhesion complexes, and disrupts cell migration. These data identify the dynamic spatiotemporal regulation of Src-mediated syndecan-4 phosphorylation as an essential switch controlling integrin trafficking and adhesion dynamics to promote efficient cell migration. PMID:23453597

  18. Syndecan-4 phosphorylation is a control point for integrin recycling.

    PubMed

    Morgan, Mark R; Hamidi, Hellyeh; Bass, Mark D; Warwood, Stacey; Ballestrem, Christoph; Humphries, Martin J

    2013-03-11

    Precise spatiotemporal coordination of integrin adhesion complex dynamics is essential for efficient cell migration. For cells adherent to fibronectin, differential engagement of α5β1 and αVβ3 integrins is used to elicit changes in adhesion complex stability, mechanosensation, matrix assembly, and migration, but the mechanisms responsible for receptor regulation have remained largely obscure. We identify phosphorylation of the membrane-intercalated proteoglycan syndecan-4 as an essential switch controlling integrin recycling. Src phosphorylates syndecan-4 and, by driving syntenin binding, leads to suppression of Arf6 activity and recycling of αVβ3 to the plasma membrane at the expense of α5β1. The resultant elevation in αVβ3 engagement promotes stabilization of focal adhesions. Conversely, abrogation of syndecan-4 phosphorylation drives surface expression of α5β1, destabilizes adhesion complexes, and disrupts cell migration. These data identify the dynamic spatiotemporal regulation of Src-mediated syndecan-4 phosphorylation as an essential switch controlling integrin trafficking and adhesion dynamics to promote efficient cell migration.

  19. [Monitoring of a HACCP (Hazard Analysis Critical Control Point) plan for Listeria monocytogenes control].

    PubMed

    Mengoni, G B; Apraiz, P M

    2003-01-01

    The monitoring of a HACCP (Hazard Analysis Critical Control Point) plan for the Listeria monocytogenes control in the cooked and frozen meat section of a thermo-processing meat plant was evaluated. Seventy "non-product-contact" surface samples and fourteen finished product samples were examined. Thirty eight positive sites for the presence of Listeria sp. were obtained. Twenty-two isolates were identified as L. monocytogenes, two as L. seeligeri and fourteen as L. innocua. Non isolates were obtained from finished product samples. The detection of L. monocytogenes in cooked and frozen meat section environment showed the need for the HACCP plan to eliminate or prevent product contamination in the post-thermal step.

  20. The application of linear actuators for telescope pointing control

    NASA Technical Reports Server (NTRS)

    Carrington, C. K.; Davis, B. G.

    1992-01-01

    A study team at MSFC has conceptually designed two lunar-based telescopes, a 16 m aperture Large Lunar Telescope (LLT) and a 4 m Cluster Telescope Experiment (CTE). The CTE serves as a technology tested for the LLT. The CTE utilizes a hexapod telescope mount to obtain a small gimbal angle that significantly extends the viewing space and observation time from that of a stationary transit telescope. This paper addresses the applicability of six linear actuators to provide limited gimbal rotation of the CTE telescope assembly. Kinematic constraint equations for the hexapod mount have been applied to a six degree-of-freedom rigid body model. Static equilibrium equations have been solved to address configuration design issues, and a feedback tracking control system has been designed and simulated.

  1. Enhancing the Mechanical Properties of Electrospun Nanofiber Mats through Controllable Welding at the Cross Points.

    PubMed

    Li, Haoxuan; Zhu, Chunlei; Xue, Jiajia; Ke, Qinfei; Xia, Younan

    2017-03-10

    This communication describes a simple and effective method for welding electrospun nanofibers at the cross points to enhance the mechanical properties of their nonwoven mats. The welding is achieved by placing a nonwoven mat of the nanofibers in a capped vial with the vapor of a proper solvent. For polycaprolactone (PCL) nanofibers, the solvent is dichloromethane (DCM). The welding can be managed in a controllable fashion by simply varying the partial pressure of DCM and/or the exposure time. Relative to the pristine nanofiber mat, the mechanical strength of the welded PCL nanofiber mat can be increased by as much as 200%. Meanwhile, such a treatment does not cause any major structural changes, including morphology, fiber diameter, and pore size. This study provides a generic method for improving the mechanical properties of nonwoven nanofiber mats, holding great potential in various applications.

  2. 75 FR 8239 - School Food Safety Program Based on Hazard Analysis and Critical Control Point Principles (HACCP...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-24

    ... Critical Control Point Principles (HACCP); Approval of Information Collection Request AGENCY: Food and... rule entitled School Food Safety Program Based on Hazard Analysis and Critical Control Point...

  3. PI-3 kinase-PTEN signaling node: an intercept point for the control of angiogenesis.

    PubMed

    Castellino, R C; Muh, C R; Durden, D L

    2009-01-01

    Angiogenesis is tightly regulated by opposing mechanisms in mammalian cells and is controlled by the angiogenic switch. Other review articles have described a central role for the PTEN/PI-3 kinase/AKT signaling node in the coordinate control of cell division, tumor growth, apoptosis, invasion and cellular metabolism [1, 2]. In this review, we focus on literature that supports the PTEN/PI-3 kinase/AKT signaling node as a major control point for the angiogenic switch in both the on and off positions. We also discuss the rationale for designing small molecule drugs that target the PTEN/PI-3 kinase/AKT signaling node for therapeutic intervention. Our hypothesis is that, instead of inhibiting one cell surface receptor, such as VEGFR2 with bevacizumab (Avastin), thereby leaving a significant number of receptors free to pulse angiogenic signals, a more effective strategy may be to regulate signaling through an intercept node where redundant cell surface receptor signals converge to transmit important signaling events within the cell. This therapeutic configuration brings coordinate control over multiple cell surface receptors in concert with a physiologic response which may combine arrest of cell cycle progression with growth inhibition and the induction of genes involved in specialized functions such as movement, which are all required for the complex process of angiogenesis to occur in a temporal-spatial paradigm.

  4. End-point controller design for an experimental two-link flexible manipulator using convex optimization

    NASA Technical Reports Server (NTRS)

    Oakley, Celia M.; Barratt, Craig H.

    1990-01-01

    Recent results in linear controller design are used to design an end-point controller for an experimental two-link flexible manipulator. A nominal 14-state linear-quadratic-Gaussian (LQG) controller was augmented with a 528-tap finite-impulse-response (FIR) filter designed using convex optimization techniques. The resulting 278-state controller produced improved end-point trajectory tracking and disturbance rejection in simulation and experimentally in real time.

  5. Parameter Space of Fixed Points of the Damped Driven Pendulum Susceptible to Control of Chaos Algorithms

    NASA Astrophysics Data System (ADS)

    Dittmore, Andrew; Trail, Collin; Olsen, Thomas; Wiener, Richard J.

    2003-11-01

    We have previously demonstrated the experimental control of chaos in a Modified Taylor-Couette system with hourglass geometry( Richard J. Wiener et al), Phys. Rev. Lett. 83, 2340 (1999).. Identifying fixed points susceptible to algorithms for the control of chaos is key. We seek to learn about this process in the accessible numerical model of the damped, driven pendulum. Following Baker(Gregory L. Baker, Am. J. Phys. 63), 832 (1995)., we seek points susceptible to the OGY(E. Ott, C. Grebogi, and J. A. Yorke, Phys. Rev. Lett. 64), 1196 (1990). algorithm. We automate the search for fixed points that are candidates for control. We present comparisons of the space of candidate fixed points with the bifurcation diagrams and Poincare sections of the system. We demonstrate control at fixed points which do not appear on the attractor. We also show that the control algorithm may be employed to shift the system between non-communicating branches of the attractor.

  6. Robust optimal sun-pointing control of a large solar power satellite

    NASA Astrophysics Data System (ADS)

    Wu, Shunan; Zhang, Kaiming; Peng, Haijun; Wu, Zhigang; Radice, Gianmarco

    2016-10-01

    The robust optimal sun-pointing control strategy for a large geostationary solar power satellite (SPS) is addressed in this paper. The SPS is considered as a huge rigid body, and the sun-pointing dynamics are firstly proposed in the state space representation. The perturbation effects caused by gravity gradient, solar radiation pressure and microwave reaction are investigated. To perform sun-pointing maneuvers, a periodically time-varying robust optimal LQR controller is designed to assess the pointing accuracy and the control inputs. It should be noted that, to reduce the pointing errors, the disturbance rejection technique is combined into the proposed LQR controller. A recursive algorithm is then proposed to solve the optimal LQR control gain. Simulation results are finally provided to illustrate the performance of the proposed closed-loop system.

  7. Point mutations in the major outer membrane protein drive hypervirulence of a rapidly expanding clone of Campylobacter jejuni

    PubMed Central

    Wu, Zuowei; Periaswamy, Balamurugan; Sahin, Orhan; Yaeger, Michael; Plummer, Paul; Zhai, Weiwei; Shen, Zhangqi; Dai, Lei; Zhang, Qijing

    2016-01-01

    Infections due to clonal expansion of highly virulent bacterial strains are clear and present threats to human and animal health. Association of genetic changes with disease is now a routine, but identification of causative mutations that enable disease remains difficult. Campylobacter jejuni is an important zoonotic pathogen transmitted to humans mainly via the foodborne route. C. jejuni typically colonizes the gut, but a hypervirulent and rapidly expanding clone of C. jejuni recently emerged, which is able to translocate across the intestinal tract, causing systemic infection and abortion in pregnant animals. The genetic basis responsible for this hypervirulence is unknown. Here, we developed a strategy, termed “directed genome evolution,” by using hybridization between abortifacient and nonabortifacient strains followed by selection in an animal disease model and whole-genome sequence analysis. This strategy successfully identified SNPs in porA, encoding the major outer membrane protein, are responsible for the hypervirulence. Defined mutagenesis verified that these mutations were both necessary and sufficient for causing abortion. Furthermore, sequence analysis identified porA as the gene with the top genome-wide signal of adaptive evolution using Fu’s Fs, a population genetic metric for recent population size changes, which is consistent with the recent expansion of clone “sheep abortion.” These results identify a key virulence factor in Campylobacter and a potential target for the control of this zoonotic pathogen. Furthermore, this study provides general, unbiased experimental and computational approaches that are broadly applicable for efficient elucidation of disease-causing mutations in bacterial pathogens. PMID:27601641

  8. The point of no return: A fundamental limit on the ability to control thought and action.

    PubMed

    Logan, Gordon D

    2015-01-01

    Bartlett (1958. Thinking. New York: Basic Books) described the point of no return as a point of irrevocable commitment to action, which was preceded by a period of gradually increasing commitment. As such, the point of no return reflects a fundamental limit on the ability to control thought and action. I review the literature on the point of no return, taking three perspectives. First, I consider the point of no return from the perspective of the controlled act, as a locus in the architecture and anatomy of the underlying processes. I review experiments from the stop-signal paradigm that suggest that the point of no return is located late in the response system. Then I consider the point of no return from the perspective of the act of control that tries to change the controlled act before it becomes irrevocable. From this perspective, the point of no return is a point in time that provides enough "lead time" for the act of control to take effect. I review experiments that measure the response time to the stop signal as the lead time required for response inhibition in the stop-signal paradigm. Finally, I consider the point of no return in hierarchically controlled tasks, in which there may be many points of no return at different levels of the hierarchy. I review experiments on skilled typing that suggest different points of no return for the commands that determine what is typed and the countermands that inhibit typing, with increasing commitment to action the lower the level in the hierarchy. I end by considering the point of no return in perception and thought as well as action.

  9. [Microbiological controls and control points in a hake fillets manufacturing process for exportation].

    PubMed

    Estevao Belchior, S; Pucci, O H

    2000-06-01

    Indicator and foodborne pathogen microorganisms in the "for export" hake fillets manufacturing were investigated in this study. Critical control points were identified and prevention activities and control were proposed during seafood elaboration process. 45 samples of hake from sequential processing operation stages, 15 ice samples and 12 water samples from utensil washing, were collected. The samples were analyzed for their content of aerobic mesophilic bacteria, psychrotrophic bacteria, enterobacteria, total and fecal coliform bacteria, Staphylococcus aureus and the presence of Escherichia coli, Salmonella and Shigella. The analysis of the samples collected from the factory revealed that the amounts of aerobic mesophile bacteria increased during manual filleting and packaging, in comparison with raw material. Psychrotrophic bacteria were the predominant microorganisms, specially in hake samples. In addition, high levels of enterobacteria, which do not occur normally in fish, were detected in raw hake samples. Staphylococcus aureus, Escherichia coli, Salmonella and Shigella, were not isolated from any samples in this study. The goal of this work is to establish microbiological risks in the hake fillets manufacturing process and, therefore to make possible corrective and control actions to assure the quality and safety of seafood.

  10. Design of a new high-performance pointing controller for the Hubble Space Telescope

    NASA Technical Reports Server (NTRS)

    Johnson, C. D.

    1993-01-01

    A new form of high-performance, disturbance-adaptive pointing controller for the Hubble Space Telescope (HST) is proposed. This new controller is all linear (constant gains) and can maintain accurate 'pointing' of the HST in the face of persistent randomly triggered uncertain, unmeasurable 'flapping' motions of the large attached solar array panels. Similar disturbances associated with antennas and other flexible appendages can also be accommodated. The effectiveness and practicality of the proposed new controller is demonstrated by a detailed design and simulation testing of one such controller for a planar-motion, fully nonlinear model of HST. The simulation results show a high degree of disturbance isolation and pointing stability.

  11. 47 CFR 90.471 - Points of operation in internal transmitter control systems.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... control systems. 90.471 Section 90.471 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES PRIVATE LAND MOBILE RADIO SERVICES Transmitter Control Internal Transmitter Control Systems § 90.471 Points of operation in internal transmitter control systems....

  12. 47 CFR 90.471 - Points of operation in internal transmitter control systems.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... control systems. 90.471 Section 90.471 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES PRIVATE LAND MOBILE RADIO SERVICES Transmitter Control Internal Transmitter Control Systems § 90.471 Points of operation in internal transmitter control systems....

  13. Barriers to Point-of-Care Testing in India: Results from Qualitative Research across Different Settings, Users and Major Diseases

    PubMed Central

    Engel, Nora; Ganesh, Gayatri; Patil, Mamata; Yellappa, Vijayashree; Pant Pai, Nitika; Vadnais, Caroline; Pai, Madhukar

    2015-01-01

    Background Successful point-of-care testing, namely ensuring the completion of the test and treat cycle in the same encounter, has immense potential to reduce diagnostic and treatment delays, and impact patient outcomes. However, having rapid tests is not enough, as many barriers may prevent their successful implementation in point-of-care testing programs. Qualitative research on diagnostic practices may help identify such barriers across different points of care in health systems. Methods In this exploratory qualitative study, we conducted 78 semi-structured interviews and 13 focus group discussions in an urban and rural area of Karnataka, India, with healthcare providers (doctors, nurses, specialists, traditional healers, and informal providers), patients, community health workers, test manufacturers, laboratory technicians, program managers and policy-makers. Participants were purposively sampled to represent settings of hospitals, peripheral labs, clinics, communities and homes, in both the public and private sectors. Results In the Indian context, the onus is on the patient to ensure successful point-of-care testing across homes, clinics, labs and hospitals, amidst uncoordinated providers with divergent and often competing practices, in settings lacking material, money and human resources. We identified three overarching themes affecting point-of-care testing: the main theme is ‘relationships’ among providers and between providers and patients, influenced by the cross-cutting theme of ‘infrastructure’. Challenges with both result in ‘modified practices’ often favouring empirical (symptomatic) treatment over treatment guided by testing. Conclusions Even if tests can be conducted on the spot and infrastructure challenges have been resolved, relationships among providers and between patients and providers are crucial for successful point-of-care testing. Furthermore, these barriers do not act in isolation, but are interlinked and need to be examined

  14. Optimization of block-floating-point realizations for digital controllers with finite-word-length considerations.

    PubMed

    Wu, Jun; Hu, Xie-he; Chen, Sheng; Chu, Jian

    2003-01-01

    The closed-loop stability issue of finite-precision realizations was investigated for digital controllers implemented in block-floating-point format. The controller coefficient perturbation was analyzed resulting from using finite word length (FWL) block-floating-point representation scheme. A block-floating-point FWL closed-loop stability measure was derived which considers both the dynamic range and precision. To facilitate the design of optimal finite-precision controller realizations, a computationally tractable block-floating-point FWL closed-loop stability measure was then introduced and the method of computing the value of this measure for a given controller realization was developed. The optimal controller realization is defined as the solution that maximizes the corresponding measure, and a numerical optimization approach was adopted to solve the resulting optimal realization problem. A numerical example was used to illustrate the design procedure and to compare the optimal controller realization with the initial realization.

  15. Pointing and figure control system for a space-based far-IR segmented telescope

    NASA Technical Reports Server (NTRS)

    Lau, Kenneth

    1993-01-01

    A pointing and figure control system for two space-based far-IR telescopes, the 10-20 m Large Deployable Reflector and the 3.6 m Submillimeter Intermediate Mission, is described. The figure maintenance control system is designed to counter the optical elements translational and rotational changes induced by long-term thermal drifts that the support structure may experience. The pointing system applies optical truss to telescope pointing; a laser metrology system is used to transfer pointing informaton from an external fine guidance sensor to the telescope optical boresight, defined by the primary mirror, secondary mirror, and focal plane assembly.

  16. Application of a constructed wetland for non-point source pollution control.

    PubMed

    Kao, C M; Wang, J Y; Lee, H Y; Wen, C K

    2001-01-01

    In Taiwan, non-point source (NPS) pollution is one of the major causes of impairment of surface waters. The main objective of this study was to evaluate the efficacy of using constructed wetlands on NPS pollutant removal and water quality improvements. A field-scale constructed wetland system was built inside the campus of National Sun Yat-Sen University (located in southern Taiwan) to remove (1) NPS pollutants due to the stormwater runoff, and (2) part of the untreated wastewater from school drains. The constructed wetland was 40 m (L) x 30 m (W) x 1 m (D), which received approximately 85 m3 per day of untreated wastewater from school drainage pipes. The plants grown on the wetland included floating (Pistia stratiotes L.) and emergent (Phragmites communis L.) species. One major storm event and baseline water quality samples were analyzed during the monitoring period. Analytical results indicate that the constructed wetland removed a significant amount of NPS pollutants and wastewater constituents. More than 88% of nitrogen, 81% of chemical oxygen demand (COD), 85% of heavy metals, and 60% of the total suspended solids (TSS) caused by the storm runoff were removed by the wetland system before discharging. Results from this study may be applied to the design of constructed wetlands for NPS pollution control and water quality improvement.

  17. Electroacupuncture for Residual Insomnia Associated with Major Depressive Disorder: A Randomized Controlled Trial

    PubMed Central

    Yeung, Wing-Fai; Chung, Ka-Fai; Tso, Kwok-Chu; Zhang, Shi-Ping; Zhang, Zhang-Jin; Ho, Lai-Ming

    2011-01-01

    Study Objectives: To evaluate the efficacy and safety of electroacupuncture as an additional treatment for residual insomnia associated with major depressive disorder (MDD). Design: Randomized, placebo-controlled. Setting: A psychiatric outpatient clinic. Participants: 78 Chinese patients with DSM-IV-diagnosed MDD, insomnia complaint, a Hamilton Rating Scale for Depression (HDRS17) score ≤ 18, and fixed antidepressant dosage. Intervention: Electroacupuncture, minimal acupuncture (superficial needling at non-acupuncture points), or noninvasive placebo acupuncture 3 sessions weekly for 3 weeks. Measurements and Results: Insomnia Severity Index (ISI), Pittsburgh Sleep Quality Index (PSQI), HDRS17, 1 week sleep diaries, and 3 day actigraphy were administered at baseline, 1 week post-treatment, and 4 week post-treatment. There was significant group by time interaction in ISI, PSQI, and sleep diary-derived sleep efficiency (mixed-effects models, P = 0.04, P = 0.03, and P = 0.01, respectively). Post hoc pairwise comparisons revealed that electroacupuncture and minimal acupuncture were more efficacious than placebo acupuncture in ISI and PSQI at 1 week and 4 week post-treatment. Minimal acupuncture resulted in greater improvement in sleep diary-derived sleep efficiency than placebo acupuncture at 1 week post-treatment. There was no significant between-group difference in actigraphy measures, depressive symptoms, daily functioning, and hypnotic consumption, and no difference in any measures between electroacupuncture and minimal acupuncture. Conclusion: Compared with placebo acupuncture, electroacupuncture and minimal acupuncture resulted in greater improvement in subjective sleep measures at 1 week and 4 week post-treatment. No significant difference was found between electroacupuncture and minimal acupuncture, suggesting that the observed differences could be due to nonspecific effects of needling, regardless of whether it is done according to traditional Chinese

  18. Cadmium and lead residue control in a hazard analysis and critical control point (HACCP) environment.

    PubMed

    Pagan-Rodríguez, Doritza; O'Keefe, Margaret; Deyrup, Cindy; Zervos, Penny; Walker, Harry; Thaler, Alice

    2007-02-21

    In 2003-2004, the U.S. Department of Agriculture Food Safety and Inspection Service (FSIS) conducted an exploratory assessment to determine the occurrence and levels of cadmium and lead in randomly collected samples of kidney, liver, and muscle tissues of mature chickens, boars/stags, dairy cows, and heifers. The data generated in the study were qualitatively compared to data that FSIS gathered in a 1985-1986 study in order to identify trends in the levels of cadmium and lead in meat and poultry products. The exploratory assessment was necessary to verify that Hazard Analysis and Critical Control Point plans and efforts to control exposure to these heavy metals are effective and result in products that meet U.S. export requirements. A comparison of data from the two FSIS studies suggests that the incidence and levels of cadmium and lead in different slaughter classes have remained stable since the first study was conducted in 1985-1986. This study was conducted to fulfill FSIS mandate to ensure that meat, poultry, and egg products entering commerce in the United States are free of adulterants, including elevated levels of environmental contaminants such as cadmium and lead.

  19. Methodological demonstration of laser beam pointing control for space gravitational wave detection missions

    SciTech Connect

    Dong, Yu-Hui; Liu, He-Shan; Luo, Zi-Ren; Li, Yu-Qiong; Jin, Gang

    2014-07-15

    In space laser interferometer gravitational wave (G.W.) detection missions, the stability of the laser beam pointing direction has to be kept at 10 nrad/√Hz. Otherwise, the beam pointing jitter noise will dominate the noise budget and make the detection of G.W. impossible. Disturbed by the residue non-conservative forces, the fluctuation of the laser beam pointing direction could be a few μrad/√Hz at frequencies from 0.1 mHz to 10 Hz. Therefore, the laser beam pointing control system is an essential requirement for those space G.W. detection missions. An on-ground test of such beam pointing control system is performed, where the Differential Wave-front Sensing technique is used to sense the beams pointing jitter. An active controlled steering mirror is employed to adjust the beam pointing direction to compensate the jitter. The experimental result shows that the pointing control system can be used for very large dynamic range up to 5 μrad. At the interested frequencies of space G.W. detection missions, between 1 mHz and 1 Hz, beam pointing stability of 6 nrad/√Hz is achieved.

  20. Methodological demonstration of laser beam pointing control for space gravitational wave detection missions.

    PubMed

    Dong, Yu-Hui; Liu, He-Shan; Luo, Zi-Ren; Li, Yu-Qiong; Jin, Gang

    2014-07-01

    In space laser interferometer gravitational wave (G.W.) detection missions, the stability of the laser beam pointing direction has to be kept at 10 nrad/√Hz. Otherwise, the beam pointing jitter noise will dominate the noise budget and make the detection of G.W. impossible. Disturbed by the residue non-conservative forces, the fluctuation of the laser beam pointing direction could be a few μrad/√Hz at frequencies from 0.1 mHz to 10 Hz. Therefore, the laser beam pointing control system is an essential requirement for those space G.W. detection missions. An on-ground test of such beam pointing control system is performed, where the Differential Wave-front Sensing technique is used to sense the beams pointing jitter. An active controlled steering mirror is employed to adjust the beam pointing direction to compensate the jitter. The experimental result shows that the pointing control system can be used for very large dynamic range up to 5 μrad. At the interested frequencies of space G.W. detection missions, between 1 mHz and 1 Hz, beam pointing stability of 6 nrad/√Hz is achieved.

  1. Solar array pointing control for the International Space Station electrical power subsystem to optimize power delivery

    SciTech Connect

    Hill, R.C.

    1998-07-01

    Precise orientation control of the International Space Station (ISS) Electrical Power System (EPS) photovoltaic (PV) solar arrays is required for a number of reasons, including the optimization of power delivery to ISS system loads and payloads. To maximize power generation and delivery in general, the PV arrays are pointed directly at the sun with some allowance for inaccuracies in determination of where to point and in the actuation of pointing the PV arrays. Control of PV array orientation in this sun pointing mode is performed automatically by onboard hardware and software. During certain conditions, maximum power cannot be generated in automatic sun tracking mode due to shadowing of the PV arrays cast by other ISS structures, primarily adjacent PV arrays. In order to maximize the power generated, the PV arrays must be pointed away from the ideal sun pointing targets to reduce the amount of shadowing. The amount of off-pointing to maximize power is a function of many parameters such as the physical configuration of the ISS structures during the assembly timeframe, the solar beta angle and vehicle attitude. Thus the off-pointing cannot be controlled automatically and must be determined by ground operators. This paper presents an overview of ISS PV array orientation control, PV array power performance under shadowed and off-pointing conditions, and a methodology to maximize power under those same conditions.

  2. Autonomous Pointing Control of a Large Satellite Antenna Subject to Parametric Uncertainty

    PubMed Central

    Wu, Shunan; Liu, Yufei; Radice, Gianmarco; Tan, Shujun

    2017-01-01

    With the development of satellite mobile communications, large antennas are now widely used. The precise pointing of the antenna’s optical axis is essential for many space missions. This paper addresses the challenging problem of high-precision autonomous pointing control of a large satellite antenna. The pointing dynamics are firstly proposed. The proportional–derivative feedback and structural filter to perform pointing maneuvers and suppress antenna vibrations are then presented. An adaptive controller to estimate actual system frequencies in the presence of modal parameters uncertainty is proposed. In order to reduce periodic errors, the modified controllers, which include the proposed adaptive controller and an active disturbance rejection filter, are then developed. The system stability and robustness are analyzed and discussed in the frequency domain. Numerical results are finally provided, and the results have demonstrated that the proposed controllers have good autonomy and robustness. PMID:28287450

  3. Autonomous Pointing Control of a Large Satellite Antenna Subject to Parametric Uncertainty.

    PubMed

    Wu, Shunan; Liu, Yufei; Radice, Gianmarco; Tan, Shujun

    2017-03-10

    With the development of satellite mobile communications, large antennas are now widely used. The precise pointing of the antenna's optical axis is essential for many space missions. This paper addresses the challenging problem of high-precision autonomous pointing control of a large satellite antenna. The pointing dynamics are firstly proposed. The proportional-derivative feedback and structural filter to perform pointing maneuvers and suppress antenna vibrations are then presented. An adaptive controller to estimate actual system frequencies in the presence of modal parameters uncertainty is proposed. In order to reduce periodic errors, the modified controllers, which include the proposed adaptive controller and an active disturbance rejection filter, are then developed. The system stability and robustness are analyzed and discussed in the frequency domain. Numerical results are finally provided, and the results have demonstrated that the proposed controllers have good autonomy and robustness.

  4. [A landscape ecological approach for urban non-point source pollution control].

    PubMed

    Guo, Qinghai; Ma, Keming; Zhao, Jingzhu; Yang, Liu; Yin, Chengqing

    2005-05-01

    Urban non-point source pollution is a new problem appeared with the speeding development of urbanization. The particularity of urban land use and the increase of impervious surface area make urban non-point source pollution differ from agricultural non-point source pollution, and more difficult to control. Best Management Practices (BMPs) are the effective practices commonly applied in controlling urban non-point source pollution, mainly adopting local repairing practices to control the pollutants in surface runoff. Because of the close relationship between urban land use patterns and non-point source pollution, it would be rational to combine the landscape ecological planning with local BMPs to control the urban non-point source pollution, which needs, firstly, analyzing and evaluating the influence of landscape structure on water-bodies, pollution sources and pollutant removal processes to define the relationships between landscape spatial pattern and non-point source pollution and to decide the key polluted fields, and secondly, adjusting inherent landscape structures or/and joining new landscape factors to form new landscape pattern, and combining landscape planning and management through applying BMPs into planning to improve urban landscape heterogeneity and to control urban non-point source pollution.

  5. Wireless power charging using point of load controlled high frequency power converters

    DOEpatents

    Miller, John M.; Campbell, Steven L.; Chambon, Paul H.; Seiber, Larry E.; White, Clifford P.

    2015-10-13

    An apparatus for wirelessly charging a battery of an electric vehicle is provided with a point of load control. The apparatus includes a base unit for generating a direct current (DC) voltage. The base unit is regulated by a power level controller. One or more point of load converters can be connected to the base unit by a conductor, with each point of load converter comprising a control signal generator that transmits a signal to the power level controller. The output power level of the DC voltage provided by the base unit is controlled by power level controller such that the power level is sufficient to power all active load converters when commanded to do so by any of the active controllers, without generating excessive power that may be otherwise wasted.

  6. Responsiveness of Myofascial Trigger Points to Single and Multiple Trigger Point Release Massages: A Randomized, Placebo Controlled Trial.

    PubMed

    Moraska, Albert F; Schmiege, Sarah J; Mann, John D; Butryn, Nathan; Krutsch, Jason P

    2017-09-01

    This study aimed to assess the effects of single and multiple massage treatments on pressure-pain threshold (PPT) at myofascial trigger points (MTrPs) in people with myofascial pain syndrome expressed as tension-type headache. Individuals (n = 62) with episodic or chronic tension-type headache were randomized to receive 12 twice-weekly 45-min massage or sham ultrasound sessions or wait-list control. Massage focused on trigger point release (ischemic compression) of MTrPs in the bilateral upper trapezius and suboccipital muscles. PPT was measured at MTrPs with a pressure algometer pre and post the first and final (12th) treatments. PPT increased across the study timeframe in all four muscle sites tested for massage, but not sham ultrasound or wait-list groups (P < 0.0001 for suboccipital; P < 0.004 for upper trapezius). Post hoc analysis within the massage group showed (1) an initial, immediate increase in PPT (all P values < 0.05), (2) a cumulative and sustained increase in PPT over baseline (all P values < 0.05), and (3) an additional immediate increase in PPT at the final (12th) massage treatment (all P values < 0.05, except upper trapezius left, P = 0.17). Single and multiple massage applications increase PPT at MTrPs. The pain threshold of MTrPs have a great capacity to increase; even after multiple massage treatments additional gain in PPT was observed. Complete the self-assessment activity and evaluation online at http://www.physiatry.org/JournalCME CME OBJECTIVES: Upon completion of this article, the reader should be able to: (1) Understand the contribution of myofascial trigger points to myofascial pain; (2) Describe an effective treatment for decreasing tenderness of a myofascial trigger point; and (3) Discuss the relative values of single vs. multiple massage sessions on increasing pressure-pain thresholds at myofascial trigger points. Advanced ACCREDITATION: The Association of Academic Physiatrists is accredited by the Accreditation Council for

  7. Point-of-care testing for HIV in an Irish prison setting: results from three major Irish prisons.

    PubMed

    Bannan, Ciaran L; Lynch, Pamela A; Conroy, Emmett P; O'Dea, Siobhan; Surah, Saloni; Betts-Symonds, Graham; Lyons, Fiona E

    2016-10-01

    HIV is more prevalent in the prison population compared to the general population. Prison inmates are at an increased risk of blood-borne infections. Considerable stigma has been documented amongst inmates with HIV infection. In collaboration with the schools, healthcare facilities, prison authorities and inmate Irish Red Cross groups in Wheatfield, Cloverhill and Mountjoy prisons in Dublin, Ireland, the Department of Genito Urinary Medicine and Infectious Diseases at St James' Hospital in Dublin developed a campaign for raising awareness of HIV, educating inmates about HIV and tackling HIV stigma. Following this campaign, large-scale point-of-care testing for HIV was offered over a short period. In total, 741 inmates were screened for HIV. One inmate tested positive for HIV. We experienced a large number of invalid test results, requiring formal laboratory serum testing, and a small number of false positive results. Large-scale point-of-care testing in the Irish prison setting is acceptable and achievable.

  8. [Development and applications of the extracorporeal control point module on multi-mode medical images].

    PubMed

    Chen, Zhao-Qiu; Zhao, Feng-Ling; Zhu, Jian; Li, Wan-Hu; Fu, Zheng; Hu, Xu-Dong

    2008-07-01

    This paper introduces a display module which can be used on multi-mode medical images. The module has a small size and can be easily used for point-selecting puncture diagnosis and treatment, and registration for image fusion control points.

  9. Modeling, Identification, and Control Design for a Flexible Pointing System with Embedded Smart Materials.

    DTIC Science & Technology

    2007-11-02

    The research effort emphasized system identification , decentralized control design, and their applications to smart structures and flexible pointing...systems. The research effort had both theoretical and experimental ingredients. On the theoretical side, new system identification techniques for

  10. 46 CFR 153.297 - Emergency actuators at the point of cargo control.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... DANGEROUS CARGOES SHIPS CARRYING BULK LIQUID, LIQUEFIED GAS, OR COMPRESSED GAS HAZARDOUS MATERIALS Design... systems required by this part. (b) The point from which cargo transfer is controlled may be one of the... Handling Space Ventilation...

  11. Dynamic and control assessment of the Space Station Freedom payload pointing system

    NASA Technical Reports Server (NTRS)

    Shannon, David T., Jr.

    1991-01-01

    An analysis of the proposed Space Station Freedom Payload Pointing System (PPS) was performed to assess its dynamic payload pointing capability in the dynamic environment of the Space Station Freedom (SSF). In addition, the stability and control the the SSF was examined to verify the capability of its control devices to accommodate the impact of PPS operations. An analysis of the PPS ability to provide continuous, accurate pointing was performed and compared to the program requirements specified in the 1988 Program Definition and Requirement Document (PDRD). Results indicated that the PPS was not able to perform within the program requirements during the worst case scenario of a shuttle hard docking maneuver to the port side SSF docking adapter. The PPS maintained marginal pointing accuracy during crew treadmill activity. The Space Station attitude control system easily accommodated all PPS operations simulated. The PPS caused a negligible impact on the SSF's control environment.

  12. A Non-Linear Approach to Spacecraft Trajectory Control in the Vicinity of a Libration Point

    NASA Technical Reports Server (NTRS)

    Luquette, Richard J.; Sanner, Robert M.

    2001-01-01

    An expanding interest in mission design strategies that exploit libration point regions demands the continued development of enhanced, efficient, control algorithms for station-keeping and formation maintenance. This paper discusses the development of a non-linear, station-keeping, control algorithm for trajectories in the vicinity of a libration point. The control law guarantees exponential convergence, based on a Lyaponov analysis. Controller performance is evaluated using FreeFlyer(R) and MATLAB(R) for a spacecraft stationed near the L2 libration point in the Earth-Moon system, tracking a pre-defined reference trajectory. Evaluation metrics are fuel usage and tracking accuracy. Simulation results are compared with a linear-based controller for a spacecraft tracking the same reference trajectory. Although the analysis is framed in the context of station-keeping, the control algorithm is equally applicable to a formation flying problem with an appropriate definition of the reference trajectory.

  13. Hazard analysis and critical control point systems applied to public health risks: the example of seafood.

    PubMed

    Williams, R A; Zorn, D J

    1997-08-01

    The authors describe the way in which the two components of risk analysis--risk assessment and risk management--can be used in conjunction with the hazard analysis and critical control points concept to determine the allocation of resources at potential critical control points. This approach is examined in the context of risks to human health associated with seafood, and in particular with regard to ciguatera poisoning.

  14. Trigger point dry needling versus strain-counterstrain technique for upper trapezius myofascial trigger points: a randomised controlled trial.

    PubMed

    Segura-Ortí, E; Prades-Vergara, S; Manzaneda-Piña, L; Valero-Martínez, R; Polo-Traverso, J A

    2016-06-01

    Treatment of active myofascial trigger points includes both invasive and non-invasive techniques. To compare the effects of upper trapezius trigger point dry needling (DN) and strain-counterstrain (SCS) techniques versus sham SCS. Randomised controlled trial. 34 study subjects with active trigger points were randomly assigned to one of three treatment groups, and received either three sessions of DN (n=12), six sessions of SCS (n=10), or sham SCS (n=12) over a 3-week period. Subjective pain response and subjects' own ratings of perceived disability were measured. The analysis of variance mixed model showed a significant time effect for pain (p<0.001), elicited pain (p<0.001), pain pressure threshold (p<0.01), and neck disability index (p=0.016). Pain at rest decreased in all groups, as follows: DN 18.5 mm (95% CI 4.3 to 32.7 mm); SCS 28.3 mm (95% CI 12.4 to 44.1 mm); sham SCS 21.9 mm (95% CI 3.5 to 40.1 mm). Reductions in disability score (points) were significant in the SCS group (5.5, 95% CI 1.6 to 9.4) but not in the DN (1.4, 95% CI -4.9 to 2.1) or sham SCS (1.8, 95% CI -6.4 to 2.7) groups. There was no significant group×time interaction effect for any variables studied. There were no differences between the sham SCS, SCS, and DN groups in any of the outcome measures. DN relieved pain after fewer sessions than SCS and sham SCS, and thus may be a more efficient technique. Future studies should include a larger sample size. NCT01290653. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  15. The Use of Principal Components for Creating Improved Imagery for Geometric Control Point Selection

    NASA Technical Reports Server (NTRS)

    Imhoff, M. L.

    1982-01-01

    A directed principal component (PC) analysis and its transformation was applied to 7-channel thematic mapper simulator (TMS) data and 4-channel LANDSAT multispectral scanner system (MSS) data collected over the city of Lancaster, Pennsylvania, to create improved imagery for geometric control point selection for image to image registration. Nineteen temporally stable geometric control points, such as road interactions and bridges, were selected for a 236 sq km area. The control points were visible on both the TMS and MSS imagery. On the first attempt the corresponding image control points were selected on both data sets without using the principal components transformation. Many of the road intersection locations were visible but the actual road crossings could not be distinguished. As a result, mensuration errors using raw data exceeded the equivalent of two (79 x 79 m) pixels. The application of a guided principal components transformation yielded TMS and MSS single band images showing improved detail in the scene's urban and residential infrastructure. The PC transformed data sets were then utilized for the reselection of geometric control points. By shown greater detail, control points on both the TMS and MSS imagery could be located with greater precision using the PC transformed data.

  16. The Feasibility of the Disturbance Accommodating Controller for Precision Antenna Pointing

    NASA Technical Reports Server (NTRS)

    Gresham, L. L.; Lansing, F. L.; Guiar, C. N.

    1988-01-01

    The objective of this study is to investigate the feasibility of a pointing (position loop) controller for the NASA-JPL Deep Space Network (DSN) antennas using the Disturbance Accommodating Control (DAC) theory. A model that includes state dependent disturbances was developed, and an example demonstrating the noise estimator is presented as an initial phase in the controller design. The goal is to improve pointing accuracy by the removal of the systematic errors caused by the antenna misalignment as well as sensor noise and random wind and thermal disturbances. Preliminary simulation results show that the DAC technique is successful in both cancelling the imposed errors and maintaining an optimal control policy.

  17. Simulation of flexible appendage interactions with Mariner Venus/Mercury attitude control and science platform pointing

    NASA Technical Reports Server (NTRS)

    Fleischer, G. E.

    1973-01-01

    A new computer subroutine, which solves the attitude equations of motion for any vehicle idealized as a topological tree of hinge-connected rigid bodies, is used to simulate and analyze science instrument pointing control interaction with a flexible Mariner Venus/Mercury (MVM) spacecraft. The subroutine's user options include linearized or partially linearized hinge-connected models whose computational advantages are demonstrated for the MVM problem. Results of the pointing control/flexible vehicle interaction simulations, including imaging experiment pointing accuracy predictions and implications for MVM science sequence planning, are described in detail.

  18. Simulation of flexible appendage interactions with Mariner Venus/Mercury attitude control and science platform pointing

    NASA Technical Reports Server (NTRS)

    Fleischer, G. E.

    1973-01-01

    A new computer subroutine, which solves the attitude equations of motion for any vehicle idealized as a topological tree of hinge-connected rigid bodies, is used to simulate and analyze science instrument pointing control interaction with a flexible Mariner Venus/Mercury (MVM) spacecraft. The subroutine's user options include linearized or partially linearized hinge-connected models whose computational advantages are demonstrated for the MVM problem. Results of the pointing control/flexible vehicle interaction simulations, including imaging experiment pointing accuracy predictions and implications for MVM science sequence planning, are described in detail.

  19. Antenna pointing system for satellite tracking based on Kalman filtering and model predictive control techniques

    NASA Astrophysics Data System (ADS)

    Souza, André L. G.; Ishihara, João Y.; Ferreira, Henrique C.; Borges, Renato A.; Borges, Geovany A.

    2016-12-01

    The present work proposes a new approach for an antenna pointing system for satellite tracking. Such a system uses the received signal to estimate the beam pointing deviation and then adjusts the antenna pointing. The present work has two contributions. First, the estimation is performed by a Kalman filter based conical scan technique. This technique uses the Kalman filter avoiding the batch estimator and applies a mathematical manipulation avoiding the linearization approximations. Secondly, a control technique based on the model predictive control together with an explicit state feedback solution are obtained in order to reduce the computational burden. Numerical examples illustrate the results.

  20. Costs and water quality effects of controlling point and nonpoint pollution sources

    SciTech Connect

    Macal, C.M.; Broomfield, B.J.

    1980-01-01

    Costs and water quality effects of controlling point and nonpoint pollution sources are compared for the DuPage River basin in northern Illinois. Costs are estimated for effluent standards for municipal wastewater treatment plants and for the alternative, controlling runoff from nonpoint sources such as streets, agricultural lands, and forests. A dynamic water-quality/hydrology simulation model is used to determine water quality effects of various treatment plant standards and nonpoint-source controls. Costs and water quality data are combined, and the point-source and nonpoint-source plans are compared on a cost-effectiveness basis. Nonpoint-source controls are found to be more cost-effective than stricter control of pollutants from point sources.

  1. Precision beam pointing control with jitter attenuation by optical deflector exhibiting dynamic hysteresis in COIL

    NASA Astrophysics Data System (ADS)

    Ma, Yan-Hua; Zhang, Zeng-Bao; Zhang, Zhi-Guo; Liu, Qin; He, Xin; Shi, Wen-Bo; Mao, Jian-Qin; Jin, Yu-Qi

    2015-02-01

    Due to the existence of various disturbances during the lasing process of the chemical oxygen iodine laser (COIL), the optical beam pointing performance is severely degraded. In this paper, an adaptive control methodology is proposed for the precise pointing control of the optical beam with active beam jitter rejection using a giant magnetostrictive optical deflector (GMOD) which exhibits severe dynamic hysteresis nonlinearity. In particular, a least square support vector machine (LS-SVM) based fast compensator is employed to eliminate the dynamic hysteresis without the inverse model construction. Then an improved feedforward adaptive filter is developed to deal with jitter attenuation when the full-coherent reference signal is unavailable. To improve the stability and overall robustness of the controller, especially when a large initial bias exists, a PI controller is placed in parallel with the adaptive filter. Experimental results validate the precise pointing ability of the proposed control method.

  2. Global shape estimates and GIS cartography of Io and Enceladus using new control point network

    NASA Astrophysics Data System (ADS)

    Nadezhdina, I.; Patraty, V.; Shishkina, L.; Zhukov, D.; Zubarev, A.; Karachevtseva, I.; Oberst, J.

    2012-04-01

    We have analyzed a total of 53 Galileo and Voyager images of Io and 54 Cassini images of Enceladus to derive new geodetic control point networks for the two satellites. In order to derive the network for Io we used a subset of 66 images from those used in previous control point network studies [1, 2]. Additionally we have carried out new point measurements. We used recently reconstructed Galileo spacecraft trajectory data, supplied by the spacecraft navigation team of JPL. A total of 1956 tie point measurements for Io and 4392 ones for Enceladus have been carried out, which were processed by performing photogrammetric bundle block adjustments. Measurements and block adjustments were performed by means of the «PHOTOMOD» software [3] which was especially adapted for this study to accommodate global networks of small bodies, such as Io and Enceladus. As a result, two catalogs with the Cartesian three-dimensional coordinates of 197 and 351 control points were obtained for Io and Enceladus, respectively. The control points for Io have a mean overall accuracy of 4985.7 m (RMS). The individual accuracy of the control points for Enceladus differ substantially over the surface (the range is from 0.1 to 36.0 km) because images lack coverage and resolutions. We also determine best-fit spheres, spheroids, and tri-axial ellipsoids. The centers of the models were found to be shifted from the coordinate system origin attesting to possible errors in the ephemeris of Io. Conclusion and Future work: A comparison of our results for Io with the most recent control point network analysis [2] has revealed that we managed to derive the same accuracy of the control points using a smaller number of images and measurements (This study: 1956 measurements, DLR study: 4392). This probably attests to the fact that the now available new navigation data are internally more consistent. At present an analysis of the data is in progress. We report that control point measurements and global network

  3. [Major advances in oncology in 2014: the editorial board of the Bulletin du Cancer point of view].

    PubMed

    Massard, Christophe; Bay, Jacques-Olivier; André, Thierry; Blay, Jean-Yves; Goncalves, Anthony; Orbach, Daniel; Wislez, Marie; Thariat, Juliette; Magné, Nicolas; Vignot, Stéphane

    2015-01-01

    Results of many clinical trials are presented each year during the American Society of Clinical Oncology meeting, ESMO meeting and other international major meetings. This article is proposed by the editorial board of the Bulletin du Cancer as a synthesis of new important results in clinical trials concerning cancer patients treated for hematology cancer or solid tumors. The goal of this review is to highlight the main results that may have an immediate impact on our clinical practices for physicians and patients. Copyright © 2014 Société Française du Cancer. Published by Elsevier Masson SAS. All rights reserved.

  4. Disease progression subtype discovery from longitudinal EMR data with a majority of missing values and unknown initial time points

    PubMed Central

    Huopaniemi, Ilkka; Nadkarni, Girish; Nadukuru, Rajiv; Lotay, Vaneet; Ellis, Steve; Gottesman, Omri; Bottinger, Erwin P

    2014-01-01

    Electronic medical records (EMR) contain a longitudinal collection of laboratory data that contains valuable phenotypic information on disease progression of a large collection of patients. These data can be potentially used in medical research or patient care; finding disease progression subtypes is a particularly important application. There are, however, two significant difficulties in utilizing this data for statistical analysis: (a) a large proportion of data is missing and (b) patients are in very different stages of disease progression and there are no well-defined start points of the time series. We present a Bayesian machine learning model that overcomes these difficulties. The method can use highly incomplete time-series measurement of varying lengths, it aligns together similar trajectories in different phases and is capable of finding consistent disease progression subtypes. We demonstrate the method on finding chronic kidney disease progression subtypes. PMID:25954377

  5. Control of end-point forces of a multijoint limb by functional neuromuscular stimulation.

    PubMed

    Lan, N; Crago, P E; Chizeck, H J

    1991-10-01

    A multivariable feedback controller was designed and tested for regulating the magnitude and orientation of the force vector at the end point of a multijoint limb in contact with an isometric load. The force vector was produced by electrical stimulation of muscles. To achieve arbitrary control of end-point force magnitude and orientation, two coupling issues must be dealt with by the control system. First, there is a geometric coupling between the end-point force vector and joint torques. The amplitude and orientation of the force vector depend on the limb geometry. Second, torques at two joints may be coupled due to activation of muscles that cross them (biarticular coupling). To eliminate the geometric coupling, a transformation of controller error from the Cartesian space to the joint space was employed. A multivariable proportional-plus-integral (PI) control law was used to calculate muscle activation based on the transformed controller error. Centralized and decentralized controls were investigated for decoupling the effects of biarticular muscles. The results obtained from cat experiments showed that the magnitude and orientation of the end-point forces of the cat hindlimb could be regulated by this controller. In the presence of strong biarticular coupling, centralized control yielded better performance than decentralized control during transient responses. Both control strategies could decouple the biarticular muscle at steady state. When no biarticular coupling was present, centralized control sometimes performed worse than decentralized control. This is the first step in the simultaneous control of multiple joints by functional neuromuscular stimulation (FNS). The controller has broad potential applications in FNS neural prostheses.

  6. Point-of-care testing for sexually transmitted infections: recent advances and implications for disease control

    PubMed Central

    Tucker, Joseph D.; Bien, Cedric H.; Peeling, Rosanna W.

    2013-01-01

    Purpose of review Sexually transmitted infections (STIs) remain a major global public health issue, with more than 448 million incident bacterial infections each year. We review recent advances in STI point-of-care (POC) testing and implications for STI prevention and control. Recent findings Accurate immunochromatographic assays to detect HIV, hepatitis C virus (HCV) and syphilis antibodies have made home or supervised self-testing possible. Several studies have demonstrated feasibility and excellent test characteristics for HIV, HCV and syphilis POC tests. Rapid oral HIV tests are now available for purchase at retail sites across the United States. Combined HIV and syphilis tests using a single finger prick blood sample are under evaluation. Summary Oral POC STI tests with comparable performance to blood-based POC tests are available for self-testing. POC tests can expand screening, improve syndromic management and reduce loss to follow up. POC STI tests have the potential to facilitate prompt treatment and partner services. POC STI tests create opportunities for new social and financial models of community-based testing services. Increasing equity and access to testing will create challenges in linkage to care, quality assurance, partner services and surveillance. These important developments warrant research to understand appropriate contexts for implementation. PMID:23242343

  7. Paleogeographic controls of coal accumulation, Cretaceous Blackhawk Formation and Star Point Sandstone, Wasatch Plateau, Utah.

    USGS Publications Warehouse

    Flores, R.M.; Blanchard, L.F.; Sanchez, J.D.; Marley, W.E.; Muldoon, W.J.

    1984-01-01

    Considers the paleogeographic controls affecting the accumulation of coals in delta-barrier-island complexes. Progradation, lateral shifting, and abandonment of these complexes created four major landward-thinning tongues.-from Authors

  8. 47 CFR 90.471 - Points of operation in internal transmitter control systems.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... licensee for internal communications and transmitter control purposes. Operating positions in internal... 47 Telecommunication 5 2012-10-01 2012-10-01 false Points of operation in internal transmitter control systems. 90.471 Section 90.471 Telecommunication FEDERAL COMMUNICATIONS COMMISSION...

  9. 47 CFR 90.471 - Points of operation in internal transmitter control systems.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... licensee for internal communications and transmitter control purposes. Operating positions in internal... 47 Telecommunication 5 2014-10-01 2014-10-01 false Points of operation in internal transmitter control systems. 90.471 Section 90.471 Telecommunication FEDERAL COMMUNICATIONS COMMISSION...

  10. 47 CFR 90.471 - Points of operation in internal transmitter control systems.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... licensee for internal communications and transmitter control purposes. Operating positions in internal... 47 Telecommunication 5 2013-10-01 2013-10-01 false Points of operation in internal transmitter control systems. 90.471 Section 90.471 Telecommunication FEDERAL COMMUNICATIONS COMMISSION...

  11. Hazard analysis and critical control point (HACCP) history and conceptual overview.

    PubMed

    Hulebak, Karen L; Schlosser, Wayne

    2002-06-01

    The concept of Hazard Analysis and Critical Control Point (HACCP) is a system that enables the production of safe meat and poultry products through the thorough analysis of production processes, identification of all hazards that are likely to occur in the production establishment, the identification of critical points in the process at which these hazards may be introduced into product and therefore should be controlled, the establishment of critical limits for control at those points, the verification of these prescribed steps, and the methods by which the processing establishment and the regulatory authority can monitor how well process control through the HACCP plan is working. The history of the development of HACCP is reviewed, and examples of practical applications of HACCP are described.

  12. Acupuncture-Point Stimulation for Postoperative Pain Control: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

    PubMed Central

    Liu, Xian-Liang; Tan, Jing-Yu; Molassiotis, Alex; Suen, Lorna K. P.; Shi, Yan

    2015-01-01

    The purpose of this study was to evaluate the effectiveness of Acupuncture-point stimulation (APS) in postoperative pain control compared with sham/placebo acupuncture or standard treatments (usual care or no treatment). Only randomized controlled trials (RCTs) were included. Meta-analysis results indicated that APS interventions improved VAS scores significantly and also reduced total morphine consumption. No serious APS-related adverse effects (AEs) were reported. There is Level I evidence for the effectiveness of body points plaster therapy and Level II evidence for body points electroacupuncture (EA), body points acupressure, body points APS for abdominal surgery patients, auricular points seed embedding, manual auricular acupuncture, and auricular EA. We obtained Level III evidence for body points APS in patients who underwent cardiac surgery and cesarean section and for auricular-point stimulation in patients who underwent abdominal surgery. There is insufficient evidence to conclude that APS is an effective postoperative pain therapy in surgical patients, although the evidence does support the conclusion that APS can reduce analgesic requirements without AEs. The best level of evidence was not adequate in most subgroups. Some limitations of this study may have affected the results, possibly leading to an overestimation of APS effects. PMID:26568767

  13. De novo microdeletions and point mutations affecting SOX2 in three individuals with intellectual disability but without major eye malformations.

    PubMed

    Dennert, Nicola; Engels, Hartmut; Cremer, Kirsten; Becker, Jessica; Wohlleber, Eva; Albrecht, Beate; Ehret, Julia K; Lüdecke, Hermann-Josef; Suri, Mohnish; Carignani, Giulia; Renieri, Alessandra; Kukuk, Guido M; Wieland, Thomas; Andrieux, Joris; Strom, Tim M; Wieczorek, Dagmar; Dieux-Coëslier, Anne; Zink, Alexander M

    2017-02-01

    Loss-of-function mutations and deletions of the SOX2 gene are known to cause uni- and bilateral anophthalmia and microphthalmia as well as related disorders such as anophthalmia-esophageal-genital syndrome. Thus, anophthalmia/microphthalmia is the primary indication for targeted, "phenotype first" analyses of SOX2. However, SOX2 mutations are also associated with a wide range of non-ocular abnormalities, such as postnatal growth retardation, structural brain anomalies, hypogenitalism, and developmental delay. The present report describes three patients without anophthalmia/microphthalmia and loss-of-function mutations or microdeletions of SOX2 who had been investigated in a "genotype first" manner due to intellectual disability/developmental delay using whole exome sequencing or chromosomal microarray analyses. This result prompted us to perform SOX2 Sanger sequencing in 192 developmental delay/intellectual disability patients without anophthalmia or microphthalmia. No additional SOX2 loss-of-function mutations were detected in this cohort, showing that SOX2 is clearly not a major cause of intellectual disability without anophthalmia/microphthalmia. In our three patients and four further, reported "genotype first" SOX2 microdeletion patients, anophthalmia/microphthalmia was present in less than half of the patients. Thus, SOX2 is another example of a gene whose clinical spectrum is broadened by the generation of "genotype first" findings using hypothesis-free, genome-wide methods. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  14. Performance indicators for initial regional medical response to major incidents: a possible quality control tool.

    PubMed

    Nilsson, Heléne; Vikström, Tore; Jonson, Carl-Oscar

    2012-12-17

    Timely decisions concerning mobilization and allocation of resources and distribution of casualties are crucial in medical management of major incidents. The aim of this study was to evaluate documented initial regional medical responses to major incidents by applying a set of 11 measurable performance indicators for regional medical command and control and test the feasibility of the indicators. Retrospective data were collected from documentation from regional medical command and control at major incidents that occurred in two Swedish County Councils. Each incident was assigned to one of nine different categories and 11 measurable performance indicators for initial regional medical command and control were systematically applied. Two-way analysis of variance with one observation per cell was used for statistical analysis and the post hoc Tukey test was used for pairwise comparisons. The set of indicators for regional medical command and control could be applied in 102 of the 130 major incidents (78%), but 36 incidents had to be excluded due to incomplete documentation. The indicators were not applicable as a set for 28 incidents (21.5%) due to different characteristics and time frames. Based on the indicators studied in 66 major incidents, the results demonstrate that the regional medical management performed according to the standard in the early phases (1-10 min after alert), but there were weaknesses in the secondary phase (10-30 min after alert). The significantly lowest scores were found for Indicator 8 (formulate general guidelines for response) and Indicator 10 (decide whether or not resources in own organization are adequate). Measurable performance indicators for regional medical command and control can be applied to incidents that directly or indirectly involve casualties provided there is sufficient documentation available. Measurable performance indicators can enhance follow- up and be used as a structured quality control tool as well as constitute

  15. Attitude control/momentum management and payload pointing in advanced space vehicles

    NASA Technical Reports Server (NTRS)

    Parlos, Alexander G.; Jayasuriya, Suhada

    1990-01-01

    The design and evaluation of an attitude control/momentum management system for highly asymmetric spacecraft configurations are presented. The preliminary development and application of a nonlinear control system design methodology for tracking control of uncertain systems, such as spacecraft payload pointing systems are also presented. Control issues relevant to both linear and nonlinear rigid-body spacecraft dynamics are addressed, whereas any structural flexibilities are not taken into consideration. Results from the first task indicate that certain commonly used simplifications in the equations of motions result in unstable attitude control systems, when used for highly asymmetric spacecraft configurations. An approach is suggested circumventing this problem. Additionally, even though preliminary results from the second task are encouraging, the proposed nonlinear control system design method requires further investigation prior to its application and use as an effective payload pointing system design technique.

  16. Tensiomyography, sonoelastography, and mechanosensitivity differences between active, latent, and control low back myofascial trigger points

    PubMed Central

    Calvo-Lobo, César; Diez-Vega, Ignacio; Martínez-Pascual, Beatriz; Fernández-Martínez, Silvia; de la Cueva-Reguera, Mónica; Garrosa-Martín, Gerson; Rodríguez-Sanz, David

    2017-01-01

    Abstract The myofascial pain syndrome (MPS) is considered the most common musculoskeletal condition. The lumbopelvic pain (LPP) is established as one of the most prevalent musculoskeletal disorders. Nevertheless, previous research has not yet studied the contractibility changes by tensiomyography between myofascial trigger point (MTrP) types and normal tissue. Therefore, the aim of this study was to determine the tensiomyography, sonoelastography, and pressure pain threshold (PPT) differences between the palpation area of active and latent MTrPs with regards to control points in the lumbar erector spinae muscles of subjects with LPP. A cross-sectional descriptive study was performed. A convenience sample of 60 points (20 active MTrPs, 20 latent MTrPs, and 20 control points) was registered bilaterally in the lumbar erector spinae muscles from subjects with nonspecific LPP. The palpation order of active MTrPs, latent MTrPs, or control points was randomized for each side. The outcome assessors were blinded to the order or point type. The outcome measurements order for each point was sonoelastography manual strain index, tensiomyography, and PPT, separated by 15 minutes. Five contractile objective parameters were: maximal radial displacement (Dm), contraction time (Tc), sustain time (Ts), delay time (Td), and half-relaxation time (Tr). Tensiomyography parameters did not show any statistically significant difference (P > 0.05) between active MTrPs, latent MTrPs, and control points. Nevertheless, PPT and sonoelastography showed statistically significant differences (P < 0.05) between all point types, except for active and latent MTrPs PPT comparison (P = 0.091). Regarding the active MTrPs, a moderate positive correlation was observed between PPT and Dm (P = 0.047; τB = 0.450). Considering the control points, a moderate positive correlation was shown between sonoelastography and Td (P = 0.044; τB = 0.328). The tensiomyography contractile

  17. Fish oil supplementation in the treatment of major depression: a randomised double-blind placebo-controlled trial.

    PubMed

    Grenyer, Brin F S; Crowe, Trevor; Meyer, Barbara; Owen, Alice J; Grigonis-Deane, Elizabeth M; Caputi, Peter; Howe, Peter R C

    2007-10-01

    Dietary deficiencies in essential omega-3 polyunsaturated fatty acids derived from fish are associated with depression and some fish oils may have therapeutic benefits. We aimed to determine whether taking tuna fish oil confers any additional benefit to conventional outpatient treatment for major depression. A randomized double-blind placebo-controlled four-month trial comparing tuna fish oil versus placebo was conducted on 83 outpatients with major depression. Despite large reductions in depression there were no significant differences at any assessment time point between patients receiving fish oil compared to placebo. Red blood cell incorporation of fatty acids indicated good compliance with oil supplementation, although this sample was not initially deficient in omega-3s. This particular dose and type of fish oil conferred no additional benefit to conventional treatment of depression in this sample. Future studies could target participants with pre-existing omega-3 deficiency and appraise alternate enriched types and higher doses of omega-3 supplementation.

  18. Great lakes eutrophication: the effect of point source control of total phosphorus.

    PubMed

    Chapra, S C; Robertson, A

    1977-06-24

    A mathematical model of the Great Lakes total phosphorus budgets indicates that a 1 milligram per liter effluent restriction for point sources would result in significant improvement in the trophic status of most of the system. However, because large areas of their drainage basins are devoted to agriculture or are urbanized, western Lake Erie, lower Green Bay, and Saginaw Bay may require non-point source controls to effect significant improvements in their trophic status.

  19. Reducing Pointing Errors During Cassini Reaction Control System Orbit Trim Maneuvers

    NASA Technical Reports Server (NTRS)

    Rizvi, Farheen

    2013-01-01

    The effect of altering a gain parameter in the Cassini reaction control system (RCS) delta-V controller on the maneuver execution errors during orbit trim maneuvers (OTMs) is explored. Cassini consists of two reaction control thruster branches (A & B) each with eight thrusters. Currently, the B-branch is operational while the A-branch serves as a back-up. The four Z-thrusters control the X and Y-axes, while the four Y-thrusters control the Z-axis. During an OTM, the Z-thrusters fire to maintain the X and Y-axes pointing within an attitude control dead-zone (-10 to 10 milliradians). The errors do not remain at zero due to pointing error sources such as spacecraft center of mass offset from the geometric center of the Z-facing thrusters, and variability in the thruster forces due to the thruster hardware differences. The delta-V reaction control system (RCS) controller ensures that the attitude error remains within this dead-zone. Gain parameters within the RCS delta-V controller affect the maneuver execution errors. Different parameter values are used to explore effect on these errors. It is found that pointing error decreases and magnitude error increases rapidly for gain parameters 10 times greater than the current parameter values used in the flight software.

  20. Reducing Pointing Errors During Cassini Reaction Control System Orbit Trim Maneuvers

    NASA Technical Reports Server (NTRS)

    Rizvi, Farheen

    2013-01-01

    The effect of altering a gain parameter in the Cassini reaction control system (RCS) delta-V controller on the maneuver execution errors during orbit trim maneuvers (OTMs) is explored. Cassini consists of two reaction control thruster branches (A & B) each with eight thrusters. Currently, the B-branch is operational while the A-branch serves as a back-up. The four Z-thrusters control the X and Y-axes, while the four Y-thrusters control the Z-axis. During an OTM, the Z-thrusters fire to maintain the X and Y-axes pointing within an attitude control dead-zone (-10 to 10 milliradians). The errors do not remain at zero due to pointing error sources such as spacecraft center of mass offset from the geometric center of the Z-facing thrusters, and variability in the thruster forces due to the thruster hardware differences. The delta-V reaction control system (RCS) controller ensures that the attitude error remains within this dead-zone. Gain parameters within the RCS delta-V controller affect the maneuver execution errors. Different parameter values are used to explore effect on these errors. It is found that pointing error decreases and magnitude error increases rapidly for gain parameters 10 times greater than the current parameter values used in the flight software.

  1. Acquisition Tracking and Pointing Control of the Bifocal Relay Mirror Spacecraft

    NASA Astrophysics Data System (ADS)

    Romano, Marcello; Agrawal, Brij N.

    This spacecraft consists of two large gimbaled telescopes, that are optically coupled and used to redirect a laser beam from a ground-based or spacecraft based source to a distant point on the earth or in space. The attitude control system consists of reaction wheels, star trackers and gyros. The optical control system consists of two fast steering mirrors and two optical tracker sensors. The very tight pointing and jitter requirements, together with the multi-body nature of the spacecraft, make the acquisition, tracking and pointing control very challenging. The control techniques developed in this research can be applied to imaging spacecrafts and spacecrafts with optical communications. numerical simulations. The simulations were performed to analyze two different control approaches proposed for the tracking and pointing of the Bifocal Relay Mirror spacecraft during operational phase. In the first control option considered, feed forward and feedback control are used for the spacecraft attitude control, while independent feedback is used by the optical subsystem in order to compensate the pointing error of the spacecraft. In the second control approach, the spacecraft and optical control systems are integrated. In case of uncertainty in target position and use of realistic sensors, using star tracker and rate gyros with Kalman Filter, the integrated control provides better performance. dynamics and control simulator of the Spacecraft Research and Design Center of Naval Postgraduate School. The attitude of this spherical air bearing based test-bed was controlled by three reaction wheels, while its attitude and angular velocity were sensed by an optical attitude sensor and three rate gyros, respectively. The three axes simulator platform included as payload a fully functional model of the transmitter section of the Bifocal Relay Mirror Spacecraft, consisting in one telescope with fast steering mirror and one optical tracker sensor. Two preliminary experiments have

  2. CMG-induced LST dynamics. [application of control moment gyroscope to pointing and control systems of large space telescope

    NASA Technical Reports Server (NTRS)

    Seltzer, S. M.

    1974-01-01

    The application of control moment gyroscopes to the pointing and control system of the large space telescope is discussed. The parameter plane analysis technique is used to present the nonlinearity representing the control moment gyroscope gimbal bearing friction. The technique affords both analytic and graphic portrayal of the effects of variations is selected system parameters. Diagrams of the systems involved in the tests are presented.

  3. Nested task constraints shape continuous perception-action coupling control during human locomotor pointing.

    PubMed

    Renshaw, Ian; Davids, Keith

    2004-10-14

    Behavioural studies of human locomotor pointing have been dominated by specific task constraints of generating maximal approach velocity towards spatial targets. To examine locomotor pointing under different nested task constraints, at sub-maximal approach velocities and with concomitant differences in speed-accuracy trade offs, run-ups of professional cricket bowlers (n = 6) were analysed. Inter- and intra-trial analyses of step length adjustments revealed how differences between current and required locomotor pointing behaviour constrained visual adaptations of gait. Results supported a continuous perception-action coupling control mechanism, although no relationship was observed between step number in sequence and total amount of adjustment made, implying that visual adaptations did not continue to the end of a run-up once initiated. Rather, bowlers made step adjustments throughout the run-up, with strong associations for amount of adjustment made and amount needed. Significant variations were observed in inter-individual strategies for making most adjustments at different points of the run-up. A key premise of prospective control models of locomotor pointing was found to be robust, since regulation of cricketer's gait was continuous and based on perception of current and required behaviour. Findings extend understanding of the nature and range of nested task constraints under which perception-action coupling controls locomotor pointing performance.

  4. The Hubble Space Telescope fine guidance system operating in the coarse track pointing control mode

    NASA Technical Reports Server (NTRS)

    Whittlesey, Richard

    1993-01-01

    The Hubble Space Telescope (HST) Fine Guidance System has set new standards in pointing control capability for earth orbiting spacecraft. Two precision pointing control modes are implemented in the Fine Guidance System; one being a Coarse Track Mode which employs a pseudo-quadrature detector approach and the second being a Fine Mode which uses a two axis interferometer implementation. The Coarse Track Mode was designed to maintain FGS pointing error to within 20 milli-arc seconds (rms) when guiding on a 14.5 Mv star. The Fine Mode was designed to maintain FGS pointing error to less than 3 milli-arc seconds (rms). This paper addresses the HST FGS operating in the Coarse Track Mode. An overview of the implementation, the operation, and both the predicted and observed on orbit performance is presented. The discussion includes a review of the Fine Guidance System hardware which uses two beam steering Star Selector servos, four photon counting photomultiplier tube detectors, as well as a 24 bit microprocessor, which executes the control system firmware. Unanticipated spacecraft operational characteristics are discussed as they impact pointing performance. These include the influence of spherically aberrated star images as well as the mechanical shocks induced in the spacecraft during and following orbital day/night terminator crossings. Computer modeling of the Coarse Track Mode verifies the observed on orbit performance trends in the presence of these optical and mechanical disturbances. It is concluded that the coarse track pointing control function is performing as designed and is providing a robust pointing control capability for the Hubble Space Telescope.

  5. An approach to versatile highly-uniform MOVPE growth: the flow controlled stagnation point flow reactor

    NASA Astrophysics Data System (ADS)

    Kondo, Makoto; Kuramata, Akito; Fujii, Takuya; Anayama, Chikashi; Okazaki, Jiro; Sekiguchi, Hiroshi; Tanahashi, Toshiyuki; Yamazaki, Susumu; Nakajima, Kazuo

    1992-11-01

    We present an approach to versatile highly-uniform MOVPE growth using the controlled stagnation point flow reactor. Our approach for uniform growth involves two concepts: (1) realizing the stagnation point flow condition in a vertical reactor configuration and (2) introducing a method for versatile flow-field control using the flow-controlled multiple gas-injector technique. The versatility of the flow-control technique was investigated by evaluating how radial deposition rate uniformity is affected by variation in several hydrodynamic and reactor configuration factors: the inlet flow rate, operating pressure, susceptor temperature, susceptor rotation speed, and the inlet and susceptor separation. We confirmed that a spatially uniform deposition rate can be obtained over a wide range of hydrodynamic and configuration parameters, demonstrating that the flow-control technique can provide a stable stagnation point flow field. Even when the ideal stagnation point flow-field is disturbed, for example, by high temperature susceptor heating, it could be completely compensated by adjusting the flow rate ratio for multiple injectors, showing our technique's ability to control flow-fields. By using this technique, we obtained excellent uniformities in both layer thickness and alloy composition for two important materials - GaInAsP and AlGaInP - in the same reactor.

  6. Pointing and Scanning Control of Optical Instruments using Rotating Unbalanced Masses

    NASA Technical Reports Server (NTRS)

    Bishop, Carlee A.; Hung, John Y.; Polites, Michael E.; Alhorn, Dean C.

    1996-01-01

    Correct pointing direction and scanning motions are essential in the operation of many flight payloads, such as balloon-borne telescopes and space-based X- ray and gamma-ray telescopes. Rotating unbalanced mass (RUM) devices have been recently proposed, implemented and successfully tested to produce a variety of scanning motions. Linear scans, raster scans, and circular scans have been successfully generated on a gimbaled payload using pairs of RUM devices. Theoretical analysis, computer simulations, and experiments have also been used to study the feasibility of using RUM devices to control instrument pointing direction, in addition to generating scanning motion. Dynamic modeling of a gimbaled payload equipped with a pair of RUM devices has been studied, and preliminary testing indicates that the pointing control is indeed feasible. However, there is also great potential for significant performance improvements through more advanced control system analysis, modeling and design. In this paper, modeling and control methods are described to achieve simultaneous scanning and pointing control of a gimbaled payload using rotating unbalance mass (RUM) devices. The model development work builds upon the results of Polites et al. and also some modeling approaches from robotics research. Results of some preliminary experiments are discussed and some nonlinear control methods will be proposed.

  7. A randomized controlled trial of group cognitive behavioral therapy for Chinese breast cancer patients with major depression.

    PubMed

    Qiu, Jianyin; Chen, Weijun; Gao, Xiufei; Xu, Yong; Tong, Huiqi; Yang, Min; Xiao, Zeping; Yang, Min

    2013-06-01

    This study aims to evaluate the effects of Group Cognitive Behavioral Therapy (GCBT) in treating major depression in Chinese women with breast cancer. Sixty-two breast cancer patients diagnosed with major depression were randomly assigned to GCBT group (N = 31) or a waiting list control group provided with an educational booklet (N = 31). The primary outcome measure was the 17-Item Hamilton Depression Rating Scale (17-HAMD). The second outcome measures were Self-Rating Anxiety Scale, Functional Assessment of Cancer Therapy - Breast and Self-Esteem Scale (SES). Assessments were carried out at completion of the study and six-month afterwards. Patients in the GCBT group had a significant reduction in the 17-HAMD mean score by 9 points (p < 0.001), more than any reduction among patients in the control group from baseline to the end of therapy and a significant 7 points (p < 0.001) more reduction from baseline to six-month follow-up. GCBT also yielded significantly greater improvement than the control group with regard to quality of life (QoL; p < 0.01) and self-esteem (p < 0.05). No significant differences were found between groups on improving anxiety (p > 0.05). The results of this trial suggest that GCBT is effective for treating major depression, as well as for improving QoL and self-esteem in breast cancer patients. Chictr.org ChiCTR-TRC-11001689.

  8. The Control Point Library Building System. [for Landsat MSS and RBV geometric image correction

    NASA Technical Reports Server (NTRS)

    Niblack, W.

    1981-01-01

    The Earth Resources Observation System (EROS) Data Center in Sioux Falls, South Dakota distributes precision corrected Landsat MSS and RBV data. These data are derived from master data tapes produced by the Master Data Processor (MDP), NASA's system for computing and applying corrections to the data. Included in the MDP is the Control Point Library Building System (CPLBS), an interactive, menu-driven system which permits a user to build and maintain libraries of control points. The control points are required to achieve the high geometric accuracy desired in the output MSS and RBV data. This paper describes the processing performed by CPLBS, the accuracy of the system, and the host computer and special image viewing equipment employed.

  9. Single supplier single retailer inventory model controlled by the reorder and shipping points with sharing information

    NASA Astrophysics Data System (ADS)

    Ho, Wen-Tsung; Hsiao, Yu-Cheng

    2012-04-01

    This study investigated the integrated stochastic inventory problem for a two-stage supply chain consisting of a single retailer and a single supplier. By using batch shipment policy, the expected total cost can be significantly reduced. An equally sized batch shipment model, controlled by both the reorder and shipping points, with sharing information by enterprise resource planning and radio frequency identification is constructed. The problem is solved optimally by the proposed algorithm that determines the economic lot size, the optimal batch sizes and number of batches. A numerical example is included to illustrate the algorithmic procedures and to prove that the model controlled both by the reorder and shipping points is superior to the classic model controlled only by the reorder point.

  10. Precision Pointing Control System (PPCS) system design and analysis. [for gimbaled experiment platforms

    NASA Technical Reports Server (NTRS)

    Frew, A. M.; Eisenhut, D. F.; Farrenkopf, R. L.; Gates, R. F.; Iwens, R. P.; Kirby, D. K.; Mann, R. J.; Spencer, D. J.; Tsou, H. S.; Zaremba, J. G.

    1972-01-01

    The precision pointing control system (PPCS) is an integrated system for precision attitude determination and orientation of gimbaled experiment platforms. The PPCS concept configures the system to perform orientation of up to six independent gimbaled experiment platforms to design goal accuracy of 0.001 degrees, and to operate in conjunction with a three-axis stabilized earth-oriented spacecraft in orbits ranging from low altitude (200-2500 n.m., sun synchronous) to 24 hour geosynchronous, with a design goal life of 3 to 5 years. The system comprises two complementary functions: (1) attitude determination where the attitude of a defined set of body-fixed reference axes is determined relative to a known set of reference axes fixed in inertial space; and (2) pointing control where gimbal orientation is controlled, open-loop (without use of payload error/feedback) with respect to a defined set of body-fixed reference axes to produce pointing to a desired target.

  11. 47 CFR 90.473 - Operation of internal transmitter control systems through licensed fixed control points.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 5 2012-10-01 2012-10-01 false Operation of internal transmitter control... COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES PRIVATE LAND MOBILE RADIO SERVICES Transmitter Control Internal Transmitter Control Systems § 90.473 Operation of internal transmitter...

  12. 47 CFR 90.473 - Operation of internal transmitter control systems through licensed fixed control points.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 5 2014-10-01 2014-10-01 false Operation of internal transmitter control... COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES PRIVATE LAND MOBILE RADIO SERVICES Transmitter Control Internal Transmitter Control Systems § 90.473 Operation of internal transmitter...

  13. 47 CFR 90.473 - Operation of internal transmitter control systems through licensed fixed control points.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 5 2013-10-01 2013-10-01 false Operation of internal transmitter control... COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES PRIVATE LAND MOBILE RADIO SERVICES Transmitter Control Internal Transmitter Control Systems § 90.473 Operation of internal transmitter...

  14. Gender, College Major Selections, Classifications within Majors, and Its Relationship with Locus of Control: An Empirical Evidence for Counseling Educators

    ERIC Educational Resources Information Center

    Jemi-Alade, Tunji

    2008-01-01

    To help counselors develop strategies to enhance students' social, personal, and psychological well-being, this research provides an understanding of how students perceive their environment. Specifically examining graduate and undergraduate students, the researcher was concerned with ascertaining the effect of the college-major variable (Business…

  15. Reduced Anterior Cingulate Glutamatergic Concentrations in Childhood Ocd and Major Depression Versus Healthy Controls

    ERIC Educational Resources Information Center

    Rosenberg, David R.; Mirza, Yousha; Russell, Aileen; Tang, Jennifer; Smith, Janet M.; Banerjee, Preeya S.; Bhandari, Rashmi; Rose, Michelle; Ivey, Jennifer; Boyd, Courtney; Moore, Gregory J.

    2004-01-01

    Objective: To examine in vivo glutamatergic neurochemical alterations in the anterior cingulate cortex of pediatric patients with obsessive-compulsive disorder (OCD) without major depressive disorder (MDD) versus pediatric patients with MDD without OCD and healthy controls. Method: Single-voxel proton magnetic resonance spectroscopic examinations…

  16. Reduced Anterior Cingulate Glutamatergic Concentrations in Childhood Ocd and Major Depression Versus Healthy Controls

    ERIC Educational Resources Information Center

    Rosenberg, David R.; Mirza, Yousha; Russell, Aileen; Tang, Jennifer; Smith, Janet M.; Banerjee, Preeya S.; Bhandari, Rashmi; Rose, Michelle; Ivey, Jennifer; Boyd, Courtney; Moore, Gregory J.

    2004-01-01

    Objective: To examine in vivo glutamatergic neurochemical alterations in the anterior cingulate cortex of pediatric patients with obsessive-compulsive disorder (OCD) without major depressive disorder (MDD) versus pediatric patients with MDD without OCD and healthy controls. Method: Single-voxel proton magnetic resonance spectroscopic examinations…

  17. Fluoxetine, Smoking, and History of Major Depression: A Randomized Controlled Trial

    ERIC Educational Resources Information Center

    Spring, Bonnie; Doran, Neal; Pagoto, Sherry; McChargue, Dennis; Cook, Jessica Werth; Bailey, Katherine; Crayton, John; Hedeker, Donald

    2007-01-01

    The study was a randomized placebo-controlled trial testing whether fluoxetine selectively enhances cessation for smokers with a history of depression. Euthymic smokers with (H+, n = 109) or without (H-, n = 138) a history of major depression received 60 mg fluoxetine or placebo plus group behavioral quit-smoking treatment for 12 weeks. Fluoxetine…

  18. Fluoxetine, Smoking, and History of Major Depression: A Randomized Controlled Trial

    ERIC Educational Resources Information Center

    Spring, Bonnie; Doran, Neal; Pagoto, Sherry; McChargue, Dennis; Cook, Jessica Werth; Bailey, Katherine; Crayton, John; Hedeker, Donald

    2007-01-01

    The study was a randomized placebo-controlled trial testing whether fluoxetine selectively enhances cessation for smokers with a history of depression. Euthymic smokers with (H+, n = 109) or without (H-, n = 138) a history of major depression received 60 mg fluoxetine or placebo plus group behavioral quit-smoking treatment for 12 weeks. Fluoxetine…

  19. Point defect reduction in wide bandgap semiconductors by defect quasi Fermi level control

    NASA Astrophysics Data System (ADS)

    Reddy, P.; Hoffmann, M. P.; Kaess, F.; Bryan, Z.; Bryan, I.; Bobea, M.; Klump, A.; Tweedie, J.; Kirste, R.; Mita, S.; Gerhold, M.; Collazo, R.; Sitar, Z.

    2016-11-01

    A theoretical framework for a general approach to reduce point defect density in materials via control of defect quasi Fermi level (dQFL) is presented. The control of dQFL is achieved via excess minority carrier generation. General guidelines for controlling dQFL that lead to a significant reduction in compensating point defects in any doped material is proposed. The framework introduces and incorporates the effects of various factors that control the efficacy of the defect reduction process such as defect level, defect formation energy, bandgap, and excess minority carrier density. Modified formation energy diagrams are proposed, which illustrate the effect of the quasi Fermi level control on the defect formation energies. These formation energy diagrams provide powerful tools to determine the feasibility and requirements to produce the desired reduction in specified point defects. An experimental study of the effect of excess minority carriers on point defect incorporation in GaN and AlGaN shows an excellent quantitative agreement with the theoretical predictions. Illumination at energies larger than the bandgap is employed as a means to generate excess minority carriers. The case studies with CN in Si doped GaN, H and VN in Mg doped GaN and VM-2ON in Si doped Al0.65Ga0.35N revealed a significant reduction in impurities in agreement with the proposed theory. Since compensating point defects control the material performance (this is particularly challenging in wide and ultra wide bandgap materials), dQFL control is a highly promising technique with wide scope and may be utilized to improve the properties of various materials systems and performance of devices based upon them.

  20. Linear-quadratic-regulator pointing control system design for a high-altitude balloon payload

    SciTech Connect

    White, J.E.; Etter, J.R.

    1987-11-01

    A pointing control system design for the science package of a NASA high-altitude research balloon is described. The balloon assembly consists of a single helium balloon connected to a payload recovery parachute, payload gondola, and ballast hopper. Pointing of the scientific payload is accomplished via an arrangement of drive motors and a flywheel. Linear quadratic regulator (LQR) synthesis techniques are employed to produce the azimuth and elevation controller designs. The use of LQR synthesis is motivated by the azimuthal dynamic coupling encountered between the balloon and gondola. Two control devices are employed in azimuth, one of which is a decoupler motor and the other a flywheel. The decoupler motor is intended to isolate the gondola from the balloon such that the flywheel can be accelerated or decelerated about a steady-state angular velocity to provide precise azimuthal pointing. The multiple-input/multiple-output nature of the azimuth pointing problem is best handled in a matrix synthesis procedure such as LQR. The controller design methodology is explained, and a combination of time responses and singular value analyses are used to analytically evaluate the performance of the control system. 11 refs., 17 figs.

  1. Compound control method of neutral point voltage of three level NPC inverter based on the vector method of virtual space and hysteresis control

    NASA Astrophysics Data System (ADS)

    Yang, Fengping; Xiao, Fangfei

    2017-03-01

    Current control methods include hardware control and software control corresponding to the inherent unbalance problem of neutral point voltage in three level NPC inverter. The hardware control is rarely used due to its high cost. In this paper, a new compound control method has been presented based on the vector method of virtual space and traditional hysteresis control of neutral point voltage, which can make up the shortcoming of the virtual control without the feedback control system of neutral point voltage and the blind area of hysteresis control and control the deviation and wave of neutral point voltage. The accuracy of this method has been demonstrated by simulation.

  2. Application of solar radiation pressure to formation control near libration points

    NASA Astrophysics Data System (ADS)

    Li, Hongming

    In this dissertation, the use of solar radiation pressure (SRP) for spacecraft formation control near one of the collinear Sun-Earth or Earth-Moon libration points is investigated. Specifically, we consider whether formation spacecraft that are equipped with Sun-facing reflective surfaces (solar sail or sun shield) can exploit the solar radiation force that acts on them to perform gradual relative maneuvering. The relative motion between formation spacecraft with solar sail or sun shield near libration point is analyzed. A set of linearized equations of relative motion for libration point formations under differential solar radiation forcing is derived, with the sun shield or solar sail off-pointing angle taken as the control input variable. These equations are firstly used to study the formation reconfiguration problem. With this model, we study the existence and properties of solution trajectories that take the spacecraft from a given initial formation geometry to a desired final one in the Sun-Earth system. The existence of time-optimal transfer trajectories is also investigated. The problem of formation keeping using solar radiation pressure in the Sun-Earth system is then discussed. Since the amplitude of the SRP force is constrained by the area of sun shield and the permissible maximum off-pointing angle, the theory of regulator with constrained control is applied to design the formation-keeping controller in order to use the capacity of on-board sun shield more efficiently. A subtopic of adaption of frequency of out-of-plane relative motion using SRP is also presented. Finally, we extend the investigation to the Earth-Moon system. The modeling of relative motion with SRP in the vicinity of the translunar libration point is examined. A formation-keeping controller based on a set of equations of relative motion is developed.

  3. Optimal control problems with switching points. Ph.D. Thesis, 1990 Final Report

    NASA Technical Reports Server (NTRS)

    Seywald, Hans

    1991-01-01

    An overview is presented of the problems and difficulties that arise in solving optimal control problems with switching points. A brief discussion of existing optimality conditions is given and a numerical approach for solving the multipoint boundary value problems associated with the first-order necessary conditions of optimal control is presented. Two real-life aerospace optimization problems are treated explicitly. These are altitude maximization for a sounding rocket (Goddard Problem) in the presence of a dynamic pressure limit, and range maximization for a supersonic aircraft flying in the vertical, also in the presence of a dynamic pressure limit. In the second problem singular control appears along arcs with active dynamic pressure limit, which in the context of optimal control, represents a first-order state inequality constraint. An extension of the Generalized Legendre-Clebsch Condition to the case of singular control along state/control constrained arcs is presented and is applied to the aircraft range maximization problem stated above. A contribution to the field of Jacobi Necessary Conditions is made by giving a new proof for the non-optimality of conjugate paths in the Accessory Minimum Problem. Because of its simple and explicit character, the new proof may provide the basis for an extension of Jacobi's Necessary Condition to the case of the trajectories with interior point constraints. Finally, the result that touch points cannot occur for first-order state inequality constraints is extended to the case of vector valued control functions.

  4. Major parasitic diseases of poverty in mainland China: perspectives for better control.

    PubMed

    Wang, Jin-Lei; Li, Ting-Ting; Huang, Si-Yang; Cong, Wei; Zhu, Xing-Quan

    2016-08-01

    Significant progress has been made in the prevention, control, and elimination of human parasitic diseases in China in the past 60 years. However, parasitic diseases of poverty remain major causes of morbidity and mortality, and inflict enormous economic costs on societies.In this article, we review the prevalence rates, geographical distributions, epidemic characteristics, risk factors, and clinical manifestations of parasitic diseases of poverty listed in the first issue of the journal Infectious Diseases of Poverty on 25 October 2012. We also address the challenges facing control of parasitic diseases of poverty and provide suggestions for better control.

  5. A multiobjective model for non-point source pollution control for an off-stream reservoir catchment.

    PubMed

    Kao, J J; Chen, W J

    2003-01-01

    Phosphorus loads from agricultural non-point source pollution (NPSP) significantly degrade reservoir water quality, making adequate control of agricultural NPSP necessary for improving the water quality. Controlling NPSP is generally accomplished using various Best Management Practices (BMPs). The present study applies the Agricultural Non-Point Source Pollution (AGNPS) model to simulate NPSP loading and BMP efficiencies and establishes an enhanced multiobjective mixed-integer programming model for NPSP control strategy analyses based on these results. Cost, phosphorus load, sediment load and equity are the four major objectives considered. A case study for the Posan reservoir is presented. Four commonly proposed and applicable BMPs are chosen. Non-inferior solutions obtained using the constraint method and trade-off relationships among different control objectives are described and discussed. Compared with a previously proposed fertilizer control model, results show that the model established herein is more cost-effective and achieves better phosphorus and sediment loading reduction and equity goals. Furthermore, the current model is expected to facilitate decision-making analysis for development of an appropriate cost-sharing program to encourage adoption of appropriate BMPs by farmers.

  6. A time domain inverse dynamic method for the end point tracking control of a flexible manipulator

    NASA Technical Reports Server (NTRS)

    Kwon, Dong-Soo; Book, Wayne J.

    1991-01-01

    The inverse dynamic equation of a flexible manipulator was solved in the time domain. By dividing the inverse system equation into the causal part and the anticausal part, we calculated the torque and the trajectories of all state variables for a given end point trajectory. The interpretation of this method in the frequency domain was explained in detail using the two-sided Laplace transform and the convolution integral. The open loop control of the inverse dynamic method shows an excellent result in simulation. For real applications, a practical control strategy is proposed by adding a feedback tracking control loop to the inverse dynamic feedforward control, and its good experimental performance is presented.

  7. Immediate effect of electric point stimulation (TENS) in treating latent upper trapezius trigger points: a double blind randomised placebo-controlled trial.

    PubMed

    Gemmell, Hugh; Hilland, Axel

    2011-07-01

    The purpose of this study was to investigate the immediate effect of electric point stimulation in treating latent upper trapezius trigger points compared to placebo. Double blind randomised placebo-controlled trial. Anglo-European College of Chiropractic. Sixty participants with latent upper trapezius trigger points. Electric point stimulator type of TENS, or detuned (inactive) electric point stimulator type of TENS. The three outcome measures were pressure pain threshold at the trigger point, a numerical rating scale for pain elicited over the trigger point, and lateral cervical flexion to the side opposite the trigger point. On the outcome of pressure pain threshold the electric point stimulator group had a mean change of 0.49 (0.99) kg/cm(2), while the placebo group had a mean change of 0.45 (0.98) kg/cm(2) (t = 0.16, df = 58, p = 0.88). For change in pain over the trigger point, the electric point stimulator group had a mean decrease of 0.93 (0.87) points, while the placebo group had a mean decrease of 0.23 (0.97) points (t = 0.70, df = 58, p = 0.005). On the outcome of change in lateral cervical flexion the electric point stimulator group had a mean increase of 2.87 (4.55) degrees, while the placebo group had a mean increase of 1.99 (2.49) degrees (t = 0.92, df = 58, p = 0.36). Electric point stimulator type of TENS is superior to placebo only in reduction of pain for treating latent upper trapezius trigger points. Copyright © 2010 Elsevier Ltd. All rights reserved.

  8. Complement receptor immunoglobulin: a control point in infection and immunity, inflammation and cancer.

    PubMed

    Small, Annabelle Grace; Al-Baghdadi, Marwah; Quach, Alex; Hii, Charles; Ferrante, Antonio

    2016-01-01

    The B7 family-related protein, V-set and Ig domain (VSIG4) / Z39Ig / complement receptor immunoglobulin (CRIg), is a new player in the regulation of immunity to infection and inflammation. The unique features of this receptor as compared with classical complement receptors, CR3 and CR4, have heralded the emergence of new concepts in the regulation of innate and adaptive immunity. Its selective expression in tissue macrophages and dendritic cells has been considered of importance in host defence and in maintaining tolerance against self-antigens. Although a major receptor for phagocytosis of complement opsonised bacteria, its array of emerging functions which incorporates the immune suppressive and anti-inflammatory action of the receptor have now been realised. Accumulating evidence from mouse experimental models indicates a potential role for CRIg in protection against bacterial infection and inflammatory diseases, such as rheumatoid arthritis, type 1 diabetes and systemic lupus erythematosus, and also in promotion of tumour growth. CRIg expression can be considered as a control point in these diseases, through which inflammatory mediators, including cytokines, act. The ability of CRIg to suppress cytotoxic T cell proliferation and function may underlie its promotion of cancer growth. Thus, the unique properties of this receptor open up new avenues for understanding of the pathways that regulate inflammation during infection, autoimmunity and cancer with the potential for new drug targets to be identified. While some complement receptors may be differently expressed in mice and humans, as well as displaying different properties, mouse CRIg has a structure and function similar to the human receptor, suggesting that extrapolation to human diseases is appropriate. Furthermore, there is emerging evidence in human conditions that CRIg may be a valuable biomarker in infection and immunity, inflammatory conditions and cancer prognosis.

  9. A Flexible VHDL Floating Point Module for Control Algorithm Implementation in Space Applications

    NASA Astrophysics Data System (ADS)

    Padierna, A.; Nicoleau, C.; Sanchez, J.; Hidalgo, I.; Elvira, S.

    2012-08-01

    The implementation of control loops for space applications is an area with great potential. However, the characteristics of this kind of systems, such as its wide dynamic range of numeric values, make inadequate the use of fixed-point algorithms.However, because the generic chips available for the treatment of floating point data are, in general, not qualified to operate in space environments and the possibility of using an IP module in a FPGA/ASIC qualified for space is not viable due to the low amount of logic cells available for these type of devices, it is necessary to find a viable alternative.For these reasons, in this paper a VHDL Floating Point Module is presented. This proposal allows the design and execution of floating point algorithms with acceptable occupancy to be implemented in FPGAs/ASICs qualified for space environments.

  10. Design and Implementation of a Digital Controller for a Vibration Isolation and Vernier Pointing System

    NASA Technical Reports Server (NTRS)

    Neff, Daniel J.; Britcher, Colin P.

    1996-01-01

    This paper discusses the recommissioning of the Annular Suspension and Pointing System (ASPS), originally developed in the mid 1970's for pointing and vibration isolation of space experiments. The hardware was developed for NASA Langley Research Center by Sperry Flight Systems (now Honeywell Satellite Systems), was delivered to NASA in 1983. Recently, the hardware was loaned to Old Dominion University (ODU). The ASPS includes coarse gimbal assemblies and a Vernier Pointing Assembly (VPA) that utilize magnetic suspension to provide noncontacting vibration isolation and vernier pointing of the payload. The VPA is the main focus of this research. At ODU, the system has been modified such that it can now be operated in a l-g environment without a gravity offload. Suspension of the annular iron rotor in five degrees-of-freedom has been achieved with the use of modern switching power amplifiers and a digital controller implemented on a 486-class PC.

  11. Future path and tangent point models in the visual control of locomotion in curve driving.

    PubMed

    Lappi, Otto

    2014-10-21

    Studying human behavior in the natural context of everyday visual tasks--including locomotor tasks such as driving--can reveal visual strategies or even suggest underlying visual mechanisms. This paper reviews empirical and theoretical work in the past 20 years (1994-2014) on the visual control of steering a vehicle along a winding path-one of the most comprehensively studied forms of visually guided locomotion in humans. The focus is on on-road studies of visual behavior and what they can reveal about the visual strategies in curve driving. Theoretical models and results from simulator studies are discussed where they have direct relevance to the interpretation of on-road data. For the past 20 years, the point of departure in studies of curve driving has been tangent point orientation, and tangent point models (models based on tracking the tangent point) have become established as the default account of how vision is used in curve negotiation. More recent studies have questioned the generality of the tangent point hypothesis, however, arguing that in addition to (or instead of) the tangent point, drivers target visual reference points on their future path. Ecological validity of real-world studies often comes at the cost of methodological challenges that make the data difficult to interpret in terms of underlying mechanisms, and the limitations of existing data and the complementary roles of real-world and laboratory studies are discussed.

  12. Classical and adaptive control algorithms for the solar array pointing system of the Space Station Freedom

    NASA Technical Reports Server (NTRS)

    Ianculescu, G. D.; Klop, J. J.

    1992-01-01

    Classical and adaptive control algorithms for the solar array pointing system of the Space Station Freedom are designed using a continuous rigid body model of the solar array gimbal assembly containing both linear and nonlinear dynamics due to various friction components. The robustness of the design solution is examined by performing a series of sensitivity analysis studies. Adaptive control strategies are examined in order to compensate for the unfavorable effect of static nonlinearities, such as dead-zone uncertainties.

  13. Effect of Confinement on the Bubble Points of Hydrocarbons in Controlled-Pore Glasses

    NASA Astrophysics Data System (ADS)

    Luo, Sheng; Lutkenhaus, Jodie; Nasrabadi, Hadi; Hadi Nasrabadi Team

    2015-03-01

    Phase behavior in shale remains a challenging problem in the petroleum industry due to many complexities. One complexity is the strong surface-fluid interactions in shale nano-scale pores. These interactions can lead to a heterogeneous distribution of molecules, which conventional bulk-phase thermodynamics fails to describe. Herein, we report a study on the bubble points of various hydrocarbons confined in nanoporous controlled-pore glasses of 4.3 to 38.1 nm pore diameter. Differential scanning calorimetry is used to measure the temperature at which the gas phase begins to form (i.e. bubble point). Besides pore diameter, the relative hydrocarbon loading in the controlled-pore glass is evaluated. The findings suggest that the bubble point is dramatically affected by pore diameter.

  14. Graphical techniques to assist in pointing and control studies of orbiting spacecraft

    NASA Technical Reports Server (NTRS)

    Howell, L. W.; Ruf, J. H.

    1986-01-01

    Computer generated graphics are developed to assist in the modeling and assessment of pointing and control systems of orbiting spacecraft. Three-dimensional diagrams are constructed of the Earth and of geometrical models which resemble the spacecraft of interest. Orbital positioning of the spacecraft model relative to the Earth and the orbital ground track are then displayed. A star data base is also available which may be used for telescope pointing and star tracker field-of-views to visually assist in spacecraft pointing and control studies. A geometrical model of the Hubble Space Telescope (HST) is constructed and placed in Earth orbit to demonstrate the use of these programs. Simulated star patterns are then displayed corresponding to the primary mirror's FOV and the telescope's star trackers for various telescope orientations with respect to the celestial sphere.

  15. Design Considerations for Miniaturized Control Moment Gyroscopes for Rapid Retargeting and Precision Pointing of Small Satellites

    NASA Technical Reports Server (NTRS)

    Patankar, Kunal; Fitz-Coy, Norman; Roithmayr, Carlos M.

    2014-01-01

    This paper presents the design as well as characterization of a practical control moment gyroscope (CMG) based attitude control system (ACS) for small satellites in the 15-20 kilogram mass range performing rapid retargeting and precision pointing maneuvers. The paper focuses on the approach taken in the design of miniaturized CMGs while considering the constraints imposed by the use of commercial off-the-shelf (COTS) components as well as the size of the satellite. It is shown that a hybrid mode is more suitable for COTS based moment exchange actuators; a mode that uses the torque amplification of CMGs for rapid retargeting and direct torque capabilities of the flywheel motors for precision pointing. A simulation is provided to demonstrate on-orbit slew and pointing performance.

  16. Radiation acquisition and RBF neural network analysis on BOF end-point control

    NASA Astrophysics Data System (ADS)

    Zhao, Qi; Wen, Hong-yuan; Zhou, Mu-chun; Chen, Yan-ru

    2008-12-01

    There are some problems in Basic Oxygen Furnace (BOF) steelmaking end-point control technology at present. A new BOF end-point control model was designed, which was based on the character of carbon oxygen reaction in Basic Oxygen Furnace steelmaking process. The image capture and transformation system was established by Video for Windows (VFW) library function, which is a video software development package promoted by Microsoft Corporation. In this paper, the Radial Basic Function (RBF) neural network model was established by using the real-time acquisition information. The input parameters can acquire easily online and the output parameter is the end-point time, which can compare with the actual value conveniently. The experience results show that the predication result is ideal and the experiment results show the model can work well in the steelmaking adverse environment.

  17. Sliding mode control of magnetic suspensions for precision pointing and tracking applications

    NASA Technical Reports Server (NTRS)

    Misovec, Kathleen M.; Flynn, Frederick J.; Johnson, Bruce G.; Hedrick, J. Karl

    1991-01-01

    A recently developed nonlinear control method, sliding mode control, is examined as a means of advancing the achievable performance of space-based precision pointing and tracking systems that use nonlinear magnetic actuators. Analytic results indicate that sliding mode control improves performance compared to linear control approaches. In order to realize these performance improvements, precise knowledge of the plant is required. Additionally, the interaction of an estimating scheme and the sliding mode controller has not been fully examined in the literature. Estimation schemes were designed for use with this sliding mode controller that do not seriously degrade system performance. The authors designed and built a laboratory testbed to determine the feasibility of utilizing sliding mode control in these types of applications. Using this testbed, experimental verification of the authors' analyses is ongoing.

  18. Abnormal proactive and reactive cognitive control during conflict processing in major depression.

    PubMed

    Vanderhasselt, Marie-Anne; De Raedt, Rudi; De Paepe, Annick; Aarts, Kristien; Otte, Georges; Van Dorpe, Jan; Pourtois, Gilles

    2014-02-01

    According to the Dual Mechanisms of Control framework, cognitive control consists of two complementary components: proactive control refers to anticipatory maintenance of goal-relevant information, whereas reactive control acts as a correction mechanism that is activated when a conflict occurs. Possibly, the well-known diminished inhibitory control in response to negative stimuli in Major Depressive Disorder (MDD) patients stems from a breakdown in proactive control, and/or anomalies in reactive cognitive control. In our study, MDD patients specifically showed increased response latencies when actively inhibiting a dominant response to a sad compared with a happy face. This condition was associated with a longer duration of a dominant ERP topography (800-900 ms poststimulus onset) and a stronger activity in the bilateral dorsal anterior cingulate cortex, reflecting abnormal reactive control when inhibiting attention to a negative stimulus. Moreover, MDD patients showed abnormalities in proactive cognitive control when preparing for the upcoming imperative stimulus (abnormal modulation of the contingent negative variation component), accompanied by more activity in brain regions belonging to the default mode network. All together, deficits to inhibit attention to negative information in MDD might originate from an abnormal use of both proactive resources and reactive control processes. PsycINFO Database Record (c) 2014 APA, all rights reserved.

  19. Landscape control points: a procedure for predicting and monitoring visual impacts

    Treesearch

    R. Burton Litton

    1973-01-01

    The visual impacts of alterations to the landscape can be studied by setting up Landscape Control Points–a network of permanently established observation sites. Such observations enable the forest manager to anticipate visual impacts of management decision, select from a choice of alternative solutions, cover an area for comprehensive viewing, and establish a method to...

  20. 46 CFR 153.297 - Emergency actuators at the point of cargo control.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Emergency actuators at the point of cargo control. 153.297 Section 153.297 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES SHIPS CARRYING BULK LIQUID, LIQUEFIED GAS, OR COMPRESSED GAS HAZARDOUS MATERIALS Design...

  1. View west from near 2002survey control point 100 (C.P. #100) ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View west from near 2002-survey control point 100 (C.P. #100) showing 1950s open-pit excavation; Adit, Ditch and "pocket" out-of-view downslope on left - Steamboat Mine, Southeast slope of Steamboat Mountain, west of the junction of Forest Service Roads 1000300 and 1000365, Jacksonville, Jackson County, OR

  2. Public Data Set: Control and Automation of the Pegasus Multi-point Thomson Scattering System

    SciTech Connect

    Bodner, Grant M.; Bongard, Michael W.; Fonck, Raymond J.; Reusch, Joshua A.; Rodriguez Sanchez, Cuauhtemoc; Schlossberg, David J.

    2016-08-12

    This public data set contains openly-documented, machine readable digital research data corresponding to figures published in G.M. Bodner et al., 'Control and Automation of the Pegasus Multi-point Thomson Scattering System,' Rev. Sci. Instrum. 87, 11E523 (2016).

  3. Acute alcohol consumption impairs controlled but not automatic processes in a psychophysical pointing paradigm.

    PubMed

    Johnston, Kevin; Timney, Brian; Goodale, Melvyn A

    2013-01-01

    Numerous studies have investigated the effects of alcohol consumption on controlled and automatic cognitive processes. Such studies have shown that alcohol impairs performance on tasks requiring conscious, intentional control, while leaving automatic performance relatively intact. Here, we sought to extend these findings to aspects of visuomotor control by investigating the effects of alcohol in a visuomotor pointing paradigm that allowed us to separate the influence of controlled and automatic processes. Six male participants were assigned to an experimental "correction" condition in which they were instructed to point at a visual target as quickly and accurately as possible. On a small percentage of trials, the target "jumped" to a new location. On these trials, the participants' task was to amend their movement such that they pointed to the new target location. A second group of 6 participants were assigned to a "countermanding" condition, in which they were instructed to terminate their movements upon detection of target "jumps". In both the correction and countermanding conditions, participants served as their own controls, taking part in alcohol and no-alcohol conditions on separate days. Alcohol had no effect on participants' ability to correct movements "in flight", but impaired the ability to withhold such automatic corrections. Our data support the notion that alcohol selectively impairs controlled processes in the visuomotor domain.

  4. Springfield Processing Plant* (A Hypothetical Facility) SPP, Entry Control Point and Vehicle Gate Access Control Post Order

    SciTech Connect

    Baum, Gregory A.

    2014-06-01

    This hypothetical order provides the requirements and instructions for the Springfield Processing Plant (SPP) Vehicle Gate and Entry Control Point (ECP) in the perimeter access building. The purpose of this post is to prevent the theft, sabotage or diversion of nuclear material (NM), control access and exit at the protected area, and to respond to emergencies according the SPP Guard Force (GF) Contingency Plan and as directed by a Guard Force Supervisor.

  5. State feedback control of surge oscillations of two-point mooring system

    NASA Astrophysics Data System (ADS)

    Mitra, R. K.; Banik, A. K.; Chatterjee, S.

    2017-01-01

    Stability analysis of surge oscillations of two-point mooring system under state feedback control with time-delay is investigated. The two-point mooring system is harmonically excited and essentially represents a strongly nonlinear Duffing oscillator. In this paper, a frequency domain based method viz. incremental harmonic balance method along with arc-length continuation technique (IHBC) is first employed to identify the primary and higher order subharmonic responses which may be present in such system. The IHBC is then reformulated in a manner to treat two-point mooring system under state feedback control with time-delay and is applied to obtain control of responses in an efficient and systematic way. The stability of uncontrolled responses for primary and higher order subharmonic oscillations is obtained by Floquet's theory using Hsu' scheme; whereas the stability of controlled responses is obtained by applying semi-discretization method for delay differential equation. The study focussed on the controlling primary, higher order subharmonics and chaotic responses by considering appropriate feedback gains and delay by way of (i) appreciable reduction of primary, subharmonic responses, (ii) exclusion of all higher order subharmonics 2T, 3T, 5T and 9T (1/n subharmonics or period-n solutions), and (iii) reduction of the extent of domain of all instability phenomena represented by various type of bifurcation of solutions, jump phenomena, chaotic responses etc. In the study, negative velocity feedback is observed to be much effective than state feedback for better controlling of surge oscillation of two-point mooring system. Also, the effect of larger gain values is investigated by an extensive parametric study for vibration control with different delay values.

  6. Reconstructing 3D coastal cliffs from airborne oblique photographs without ground control points

    NASA Astrophysics Data System (ADS)

    Dewez, T. J. B.

    2014-05-01

    Coastal cliff collapse hazard assessment requires measuring cliff face topography at regular intervals. Terrestrial laser scanner techniques have proven useful so far but are expensive to use either through purchasing the equipment or through survey subcontracting. In addition, terrestrial laser surveys take time which is sometimes incompatible with the time during with the beach is accessible at low-tide. By comparison, structure from motion techniques (SFM) are much less costly to implement, and if airborne, acquisition of several kilometers of coastline can be done in a matter of minutes. In this paper, the potential of GPS-tagged oblique airborne photographs and SFM techniques is examined to reconstruct chalk cliff dense 3D point clouds without Ground Control Points (GCP). The focus is put on comparing the relative 3D point of views reconstructed by Visual SFM with their synchronous Solmeta Geotagger Pro2 GPS locations using robust estimators. With a set of 568 oblique photos, shot from the open door of an airplane with a triplet of synchronized Nikon D7000, GPS and SFM-determined view point coordinates converge to X: ±31.5 m; Y: ±39.7 m; Z: ±13.0 m (LE66). Uncertainty in GPS position affects the model scale, angular attitude of the reference frame (the shoreline ends up tilted by 2°) and absolute positioning. Ground Control Points cannot be avoided to orient such models.

  7. Loop Heat Pipe Operation Using Heat Source Temperature for Set Point Control

    NASA Technical Reports Server (NTRS)

    Ku, Jentung; Paiva, Kleber; Mantelli, Marcia

    2011-01-01

    Loop heat pipes (LHPs) have been used for thermal control of several NASA and commercial orbiting spacecraft. The LHP operating temperature is governed by the saturation temperature of its compensation chamber (CC). Most LHPs use the CC temperature for feedback control of its operating temperature. There exists a thermal resistance between the heat source to be cooled by the LHP and the LHP's CC. Even if the CC set point temperature is controlled precisely, the heat source temperature will still vary with its heat output. For most applications, controlling the heat source temperature is of most interest. A logical question to ask is: "Can the heat source temperature be used for feedback control of the LHP operation?" A test program has been implemented to answer the above question. Objective is to investigate the LHP performance using the CC temperature and the heat source temperature for feedback control

  8. Inflammatory cytokines in major depressive disorder: A case-control study.

    PubMed

    Cassano, Paolo; Bui, Eric; Rogers, Andrew H; Walton, Zandra E; Ross, Rachel; Zeng, Mary; Nadal-Vicens, Mireya; Mischoulon, David; Baker, Amanda W; Keshaviah, Aparna; Worthington, John; Hoge, Elizabeth A; Alpert, Jonathan; Fava, Maurizio; Wong, Kwok K; Simon, Naomi M

    2017-01-01

    There is mixed evidence in the literature on the role of inflammation in major depressive disorder. Contradictory findings are attributed to lack of rigorous characterization of study subjects, to the presence of concomitant medical illnesses, to the small sample sizes, and to the limited number of cytokines tested. Subjects aged 18-70 years, diagnosed with major depressive disorder and presenting with chronic course of illness, as well as matched controls ( n = 236), were evaluated by trained raters and provided blood for cytokine measurements. Cytokine levels in EDTA plasma were measured with the MILLIPLEX Multi-Analyte Profiling Human Cytokine/Chemokine Assay employing Luminex technology. The Wilcoxon rank-sum test was used to compare cytokine levels between major depressive disorder subjects and healthy volunteers, before (interleukin [IL]-1β, IL-6, and tumor necrosis factor-α) and after Bonferroni correction for multiple comparisons (IL-1α, IL-2, IL-3, IL-4, IL-5, IL-7, IL-8, IL-10, IL-12(p40), IL-12(p70), IL-13, IL-15, IFN-γ-inducible protein 10, Eotaxin, interferon-γ, monotype chemoattractant protein-1, macrophage inflammatory protein-1α, granulocyte-macrophage colony-stimulating factor and vascular endothelial growth factor). There were no significant differences in cytokine levels between major depressive disorder subjects and controls, both prior to and after correction for multiple analyses (significance set at p ⩽ 0.05 and p ⩽ 0.002, respectively). Our well-characterized examination of cytokine plasma levels did not support the association of major depressive disorder with systemic inflammation. The heterogeneity of major depressive disorder, as well as a potential sampling bias selecting for non-inflammatory depression, might have determined our findings discordant with the literature.

  9. Research on six degrees of freedom compound control technology for improving photoelectric pod pointing accuracy

    NASA Astrophysics Data System (ADS)

    Zhou, Junpeng; Li, Yan; Chen, Juan; Nian, Lun; Zhang, Haibo

    2017-08-01

    High line-of-sight (LOS) pointing precision is a prerequisite for improving the laser confrontation capability of a photoelectric interference pod. In a traditional photoelectric pod, the time delay in TV tracking reduces the system phase margin, system stability and LOS pointing precision. In view of this deficiency, a normalized LMS algorithm is introduced to compensate for the TV camera delay in the inner gimbal position loop of a two-axis and four-gimbal structure, which can allow a pod to avoid system phase margin reduction. Meanwhile, a fast steering mirror (FSM) system is used to improve the LOS pointing precision. First, this paper proposes a normalized LMS algorithm. Second, a compound control structure, with an outer gimbal analog controller and an inner gimbal lag-lead controller, is designed. Finally, the FSM beam control precision is analyzed. The experimental results show that the normalized LMS algorithm yields almost no delay; moreover, the azimuth and pitch beam control accuracies are greater by a factor of 15 and 3, respectively, compared with those of a conventional photoelectric pod.

  10. Research on six degrees of freedom compound control technology for improving photoelectric pod pointing accuracy

    NASA Astrophysics Data System (ADS)

    Zhou, Junpeng; Li, Yan; Chen, Juan; Nian, Lun; Zhang, Haibo

    2017-06-01

    High line-of-sight (LOS) pointing precision is a prerequisite for improving the laser confrontation capability of a photoelectric interference pod. In a traditional photoelectric pod, the time delay in TV tracking reduces the system phase margin, system stability and LOS pointing precision. In view of this deficiency, a normalized LMS algorithm is introduced to compensate for the TV camera delay in the inner gimbal position loop of a two-axis and four-gimbal structure, which can allow a pod to avoid system phase margin reduction. Meanwhile, a fast steering mirror (FSM) system is used to improve the LOS pointing precision. First, this paper proposes a normalized LMS algorithm. Second, a compound control structure, with an outer gimbal analog controller and an inner gimbal lag-lead controller, is designed. Finally, the FSM beam control precision is analyzed. The experimental results show that the normalized LMS algorithm yields almost no delay; moreover, the azimuth and pitch beam control accuracies are greater by a factor of 15 and 3, respectively, compared with those of a conventional photoelectric pod.

  11. Stimulus control and generalization of point-loss punishment with humans.

    PubMed Central

    O'Donnell, J; Crosbie, J; Williams, D C; Saunders, K J

    2000-01-01

    Two experiments demonstrated stimulus control and generalization of conditioned punishment with humans. In both studies, responses first were reinforced with points exchangeable for money on a variable-interval schedule in the presence of one line length (S(D)). Next, a second line length was introduced, and point loss followed every response in the presence of that line (S(D)p). In the final training condition, points were deducted at session end. Response rate was lower in the presence of the S(D)p despite equal rates of points for money in the presence of both stimuli. In generalization testing for Experiment 1, the two lines were included in a 10-line continuum; S(D)p fell in the middle and the trained SD was at one end. Lines were presented randomly, and point delivery and loss contingencies were as in training but with points available in the presence of all lines. For all subjects, response rates were lowest around S(D)p and increased towards the SD end of the continuum. Because testing included only one or two lines beyond S(D), this pattern did not rule out S(D) generalization. Thus, in Experiment 2, stimuli beyond S(D) were added to generalization tests. Response rates did not decrease as a function of distance from S(D), clarifying the demonstration of punishment generalization. PMID:10866351

  12. The Major Genetic Determinants of HIV-1 Control Affect HLA Class I Peptide Presentation

    PubMed Central

    Pereyra, Florencia; Jia, Xiaoming; McLaren, Paul J.; Telenti, Amalio; de Bakker, Paul I.W.; Walker, Bruce D.; Jia, Xiaoming; McLaren, Paul J.; Ripke, Stephan; Brumme, Chanson J.; Pulit, Sara L.; Telenti, Amalio; Carrington, Mary; Kadie, Carl M.; Carlson, Jonathan M.; Heckerman, David; de Bakker, Paul I.W.; Pereyra, Florencia; de Bakker, Paul I.W.; Graham, Robert R.; Plenge, Robert M.; Deeks, Steven G.; Walker, Bruce D.; Gianniny, Lauren; Crawford, Gabriel; Sullivan, Jordan; Gonzalez, Elena; Davies, Leela; Camargo, Amy; Moore, Jamie M.; Beattie, Nicole; Gupta, Supriya; Crenshaw, Andrew; Burtt, Noël P.; Guiducci, Candace; Gupta, Namrata; Carrington, Mary; Gao, Xiaojiang; Qi, Ying; Yuki, Yuko; Pereyra, Florencia; Piechocka-Trocha, Alicja; Cutrell, Emily; Rosenberg, Rachel; Moss, Kristin L.; Lemay, Paul; O’Leary, Jessica; Schaefer, Todd; Verma, Pranshu; Toth, Ildiko; Block, Brian; Baker, Brett; Rothchild, Alissa; Lian, Jeffrey; Proudfoot, Jacqueline; Alvino, Donna Marie L.; Vine, Seanna; Addo, Marylyn M.; Allen, Todd M.; Altfeld, Marcus; Henn, Matthew R.; Le Gall, Sylvie; Streeck, Hendrik; Walker, Bruce D.; Haas, David W.; Kuritzkes, Daniel R.; Robbins, Gregory K.; Shafer, Robert W.; Gulick, Roy M.; Shikuma, Cecilia M.; Haubrich, Richard; Riddler, Sharon; Sax, Paul E.; Daar, Eric S.; Ribaudo, Heather J.; Agan, Brian; Agarwal, Shanu; Ahern, Richard L.; Allen, Brady L.; Altidor, Sherly; Altschuler, Eric L.; Ambardar, Sujata; Anastos, Kathryn; Anderson, Ben; Anderson, Val; Andrady, Ushan; Antoniskis, Diana; Bangsberg, David; Barbaro, Daniel; Barrie, William; Bartczak, J.; Barton, Simon; Basden, Patricia; Basgoz, Nesli; Bazner, Suzane; Bellos, Nicholaos C.; Benson, Anne M.; Berger, Judith; Bernard, Nicole F.; Bernard, Annette M.; Birch, Christopher; Bodner, Stanley J.; Bolan, Robert K.; Boudreaux, Emilie T.; Bradley, Meg; Braun, James F.; Brndjar, Jon E.; Brown, Stephen J.; Brown, Katherine; Brown, Sheldon T.; Burack, Jedidiah; Bush, Larry M.; Cafaro, Virginia; Campbell, Omobolaji; Campbell, John; Carlson, Robert H.; Carmichael, J. Kevin; Casey, Kathleen K.; Cavacuiti, Chris; Celestin, Gregory; Chambers, Steven T.; Chez, Nancy; Chirch, Lisa M.; Cimoch, Paul J.; Cohen, Daniel; Cohn, Lillian E.; Conway, Brian; Cooper, David A.; Cornelson, Brian; Cox, David T.; Cristofano, Michael V.; Cuchural, George; Czartoski, Julie L.; Dahman, Joseph M.; Daly, Jennifer S.; Davis, Benjamin T.; Davis, Kristine; Davod, Sheila M.; Deeks, Steven G.; DeJesus, Edwin; Dietz, Craig A.; Dunham, Eleanor; Dunn, Michael E.; Ellerin, Todd B.; Eron, Joseph J.; Fangman, John J.W.; Farel, Claire E.; Ferlazzo, Helen; Fidler, Sarah; Fleenor-Ford, Anita; Frankel, Renee; Freedberg, Kenneth A.; French, Neel K.; Fuchs, Jonathan D.; Fuller, Jon D.; Gaberman, Jonna; Gallant, Joel E.; Gandhi, Rajesh T.; Garcia, Efrain; Garmon, Donald; Gathe, Joseph C.; Gaultier, Cyril R.; Gebre, Wondwoosen; Gilman, Frank D.; Gilson, Ian; Goepfert, Paul A.; Gottlieb, Michael S.; Goulston, Claudia; Groger, Richard K.; Gurley, T. Douglas; Haber, Stuart; Hardwicke, Robin; Hardy, W. David; Harrigan, P. Richard; Hawkins, Trevor N.; Heath, Sonya; Hecht, Frederick M.; Henry, W. Keith; Hladek, Melissa; Hoffman, Robert P.; Horton, James M.; Hsu, Ricky K.; Huhn, Gregory D.; Hunt, Peter; Hupert, Mark J.; Illeman, Mark L.; Jaeger, Hans; Jellinger, Robert M.; John, Mina; Johnson, Jennifer A.; Johnson, Kristin L.; Johnson, Heather; Johnson, Kay; Joly, Jennifer; Jordan, Wilbert C.; Kauffman, Carol A.; Khanlou, Homayoon; Killian, Robert K.; Kim, Arthur Y.; Kim, David D.; Kinder, Clifford A.; Kirchner, Jeffrey T.; Kogelman, Laura; Kojic, Erna Milunka; Korthuis, P. Todd; Kurisu, Wayne; Kwon, Douglas S.; LaMar, Melissa; Lampiris, Harry; Lanzafame, Massimiliano; Lederman, Michael M.; Lee, David M.; Lee, Jean M.L.; Lee, Marah J.; Lee, Edward T.Y.; Lemoine, Janice; Levy, Jay A.; Llibre, Josep M.; Liguori, Michael A.; Little, Susan J.; Liu, Anne Y.; Lopez, Alvaro J.; Loutfy, Mono R.; Loy, Dawn; Mohammed, Debbie Y.; Man, Alan; Mansour, Michael K.; Marconi, Vincent C.; Markowitz, Martin; Marques, Rui; Martin, Jeffrey N.; Martin, Harold L.; Mayer, Kenneth Hugh; McElrath, M. Juliana; McGhee, Theresa A.; McGovern, Barbara H.; McGowan, Katherine; McIntyre, Dawn; Mcleod, Gavin X.; Menezes, Prema; Mesa, Greg; Metroka, Craig E.; Meyer-Olson, Dirk; Miller, Andy O.; Montgomery, Kate; Mounzer, Karam C.; Nagami, Ellen H.; Nagin, Iris; Nahass, Ronald G.; Nelson, Margret O.; Nielsen, Craig; Norene, David L.; O’Connor, David H.; Ojikutu, Bisola O.; Okulicz, Jason; Oladehin, Olakunle O.; Oldfield, Edward C.; Olender, Susan A.; Ostrowski, Mario; Owen, William F.; Pae, Eunice; Parsonnet, Jeffrey; Pavlatos, Andrew M.; Perlmutter, Aaron M.; Pierce, Michael N.; Pincus, Jonathan M.; Pisani, Leandro; Price, Lawrence Jay; Proia, Laurie; Prokesch, Richard C.; Pujet, Heather Calderon; Ramgopal, Moti; Rathod, Almas; Rausch, Michael; Ravishankar, J.; Rhame, Frank S.; Richards, Constance Shamuyarira; Richman, Douglas D.; Robbins, Gregory K.; Rodes, Berta; Rodriguez, Milagros; Rose, Richard C.; Rosenberg, Eric S.; Rosenthal, Daniel; Ross, Polly E.; Rubin, David S.; Rumbaugh, Elease; Saenz, Luis; Salvaggio, Michelle R.; Sanchez, William C.; Sanjana, Veeraf M.; Santiago, Steven; Schmidt, Wolfgang; Schuitemaker, Hanneke; Sestak, Philip M.; Shalit, Peter; Shay, William; Shirvani, Vivian N.; Silebi, Vanessa I.; Sizemore, James M.; Skolnik, Paul R.; Sokol-Anderson, Marcia; Sosman, James M.; Stabile, Paul; Stapleton, Jack T.; Starrett, Sheree; Stein, Francine; Stellbrink, Hans-Jurgen; Sterman, F. Lisa; Stone, Valerie E.; Stone, David R.; Tambussi, Giuseppe; Taplitz, Randy A.; Tedaldi, Ellen M.; Telenti, Amalio; Theisen, William; Torres, Richard; Tosiello, Lorraine; Tremblay, Cecile; Tribble, Marc A.; Trinh, Phuong D.; Tsao, Alice; Ueda, Peggy; Vaccaro, Anthony; Valadas, Emilia; Vanig, Thanes J.; Vecino, Isabel; Vega, Vilma M.; Veikley, Wenoah; Wade, Barbara H.; Walworth, Charles; Wanidworanun, Chingchai; Ward, Douglas J.; Warner, Daniel A.; Weber, Robert D.; Webster, Duncan; Weis, Steve; Wheeler, David A.; White, David J.; Wilkins, Ed; Winston, Alan; Wlodaver, Clifford G.; Wout, Angelique van’t; Wright, David P.; Yang, Otto O.; Yurdin, David L.; Zabukovic, Brandon W.; Zachary, Kimon C.; Zeeman, Beth; Zhao, Meng

    2011-01-01

    Infectious and inflammatory diseases have repeatedly shown strong genetic associations within the major histocompatibility complex (MHC); however, the basis for these associations remains elusive. To define host genetic effects on the outcome of a chronic viral infection, we performed genome-wide association analysis in a multiethnic cohort of HIV-1 controllers and progressors, and we analyzed the effects of individual amino acids within the classical human leukocyte antigen (HLA) proteins. We identified >300 genome-wide significant single-nucleotide polymorphisms (SNPs) within the MHC and none elsewhere. Specific amino acids in the HLA-B peptide binding groove, as well as an independent HLA-C effect, explain the SNP associations and reconcile both protective and risk HLA alleles. These results implicate the nature of the HLA–viral peptide interaction as the major factor modulating durable control of HIV infection. PMID:21051598

  13. The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.

    PubMed

    Pereyra, Florencia; Jia, Xiaoming; McLaren, Paul J; Telenti, Amalio; de Bakker, Paul I W; Walker, Bruce D; Ripke, Stephan; Brumme, Chanson J; Pulit, Sara L; Carrington, Mary; Kadie, Carl M; Carlson, Jonathan M; Heckerman, David; Graham, Robert R; Plenge, Robert M; Deeks, Steven G; Gianniny, Lauren; Crawford, Gabriel; Sullivan, Jordan; Gonzalez, Elena; Davies, Leela; Camargo, Amy; Moore, Jamie M; Beattie, Nicole; Gupta, Supriya; Crenshaw, Andrew; Burtt, Noël P; Guiducci, Candace; Gupta, Namrata; Gao, Xiaojiang; Qi, Ying; Yuki, Yuko; Piechocka-Trocha, Alicja; Cutrell, Emily; Rosenberg, Rachel; Moss, Kristin L; Lemay, Paul; O'Leary, Jessica; Schaefer, Todd; Verma, Pranshu; Toth, Ildiko; Block, Brian; Baker, Brett; Rothchild, Alissa; Lian, Jeffrey; Proudfoot, Jacqueline; Alvino, Donna Marie L; Vine, Seanna; Addo, Marylyn M; Allen, Todd M; Altfeld, Marcus; Henn, Matthew R; Le Gall, Sylvie; Streeck, Hendrik; Haas, David W; Kuritzkes, Daniel R; Robbins, Gregory K; Shafer, Robert W; Gulick, Roy M; Shikuma, Cecilia M; Haubrich, Richard; Riddler, Sharon; Sax, Paul E; Daar, Eric S; Ribaudo, Heather J; Agan, Brian; Agarwal, Shanu; Ahern, Richard L; Allen, Brady L; Altidor, Sherly; Altschuler, Eric L; Ambardar, Sujata; Anastos, Kathryn; Anderson, Ben; Anderson, Val; Andrady, Ushan; Antoniskis, Diana; Bangsberg, David; Barbaro, Daniel; Barrie, William; Bartczak, J; Barton, Simon; Basden, Patricia; Basgoz, Nesli; Bazner, Suzane; Bellos, Nicholaos C; Benson, Anne M; Berger, Judith; Bernard, Nicole F; Bernard, Annette M; Birch, Christopher; Bodner, Stanley J; Bolan, Robert K; Boudreaux, Emilie T; Bradley, Meg; Braun, James F; Brndjar, Jon E; Brown, Stephen J; Brown, Katherine; Brown, Sheldon T; Burack, Jedidiah; Bush, Larry M; Cafaro, Virginia; Campbell, Omobolaji; Campbell, John; Carlson, Robert H; Carmichael, J Kevin; Casey, Kathleen K; Cavacuiti, Chris; Celestin, Gregory; Chambers, Steven T; Chez, Nancy; Chirch, Lisa M; Cimoch, Paul J; Cohen, Daniel; Cohn, Lillian E; Conway, Brian; Cooper, David A; Cornelson, Brian; Cox, David T; Cristofano, Michael V; Cuchural, George; Czartoski, Julie L; Dahman, Joseph M; Daly, Jennifer S; Davis, Benjamin T; Davis, Kristine; Davod, Sheila M; DeJesus, Edwin; Dietz, Craig A; Dunham, Eleanor; Dunn, Michael E; Ellerin, Todd B; Eron, Joseph J; Fangman, John J W; Farel, Claire E; Ferlazzo, Helen; Fidler, Sarah; Fleenor-Ford, Anita; Frankel, Renee; Freedberg, Kenneth A; French, Neel K; Fuchs, Jonathan D; Fuller, Jon D; Gaberman, Jonna; Gallant, Joel E; Gandhi, Rajesh T; Garcia, Efrain; Garmon, Donald; Gathe, Joseph C; Gaultier, Cyril R; Gebre, Wondwoosen; Gilman, Frank D; Gilson, Ian; Goepfert, Paul A; Gottlieb, Michael S; Goulston, Claudia; Groger, Richard K; Gurley, T Douglas; Haber, Stuart; Hardwicke, Robin; Hardy, W David; Harrigan, P Richard; Hawkins, Trevor N; Heath, Sonya; Hecht, Frederick M; Henry, W Keith; Hladek, Melissa; Hoffman, Robert P; Horton, James M; Hsu, Ricky K; Huhn, Gregory D; Hunt, Peter; Hupert, Mark J; Illeman, Mark L; Jaeger, Hans; Jellinger, Robert M; John, Mina; Johnson, Jennifer A; Johnson, Kristin L; Johnson, Heather; Johnson, Kay; Joly, Jennifer; Jordan, Wilbert C; Kauffman, Carol A; Khanlou, Homayoon; Killian, Robert K; Kim, Arthur Y; Kim, David D; Kinder, Clifford A; Kirchner, Jeffrey T; Kogelman, Laura; Kojic, Erna Milunka; Korthuis, P Todd; Kurisu, Wayne; Kwon, Douglas S; LaMar, Melissa; Lampiris, Harry; Lanzafame, Massimiliano; Lederman, Michael M; Lee, David M; Lee, Jean M L; Lee, Marah J; Lee, Edward T Y; Lemoine, Janice; Levy, Jay A; Llibre, Josep M; Liguori, Michael A; Little, Susan J; Liu, Anne Y; Lopez, Alvaro J; Loutfy, Mono R; Loy, Dawn; Mohammed, Debbie Y; Man, Alan; Mansour, Michael K; Marconi, Vincent C; Markowitz, Martin; Marques, Rui; Martin, Jeffrey N; Martin, Harold L; Mayer, Kenneth Hugh; McElrath, M Juliana; McGhee, Theresa A; McGovern, Barbara H; McGowan, Katherine; McIntyre, Dawn; Mcleod, Gavin X; Menezes, Prema; Mesa, Greg; Metroka, Craig E; Meyer-Olson, Dirk; Miller, Andy O; Montgomery, Kate; Mounzer, Karam C; Nagami, Ellen H; Nagin, Iris; Nahass, Ronald G; Nelson, Margret O; Nielsen, Craig; Norene, David L; O'Connor, David H; Ojikutu, Bisola O; Okulicz, Jason; Oladehin, Olakunle O; Oldfield, Edward C; Olender, Susan A; Ostrowski, Mario; Owen, William F; Pae, Eunice; Parsonnet, Jeffrey; Pavlatos, Andrew M; Perlmutter, Aaron M; Pierce, Michael N; Pincus, Jonathan M; Pisani, Leandro; Price, Lawrence Jay; Proia, Laurie; Prokesch, Richard C; Pujet, Heather Calderon; Ramgopal, Moti; Rathod, Almas; Rausch, Michael; Ravishankar, J; Rhame, Frank S; Richards, Constance Shamuyarira; Richman, Douglas D; Rodes, Berta; Rodriguez, Milagros; Rose, Richard C; Rosenberg, Eric S; Rosenthal, Daniel; Ross, Polly E; Rubin, David S; Rumbaugh, Elease; Saenz, Luis; Salvaggio, Michelle R; Sanchez, William C; Sanjana, Veeraf M; Santiago, Steven; Schmidt, Wolfgang; Schuitemaker, Hanneke; Sestak, Philip M; Shalit, Peter; Shay, William; Shirvani, Vivian N; Silebi, Vanessa I; Sizemore, James M; Skolnik, Paul R; Sokol-Anderson, Marcia; Sosman, James M; Stabile, Paul; Stapleton, Jack T; Starrett, Sheree; Stein, Francine; Stellbrink, Hans-Jurgen; Sterman, F Lisa; Stone, Valerie E; Stone, David R; Tambussi, Giuseppe; Taplitz, Randy A; Tedaldi, Ellen M; Telenti, Amalio; Theisen, William; Torres, Richard; Tosiello, Lorraine; Tremblay, Cecile; Tribble, Marc A; Trinh, Phuong D; Tsao, Alice; Ueda, Peggy; Vaccaro, Anthony; Valadas, Emilia; Vanig, Thanes J; Vecino, Isabel; Vega, Vilma M; Veikley, Wenoah; Wade, Barbara H; Walworth, Charles; Wanidworanun, Chingchai; Ward, Douglas J; Warner, Daniel A; Weber, Robert D; Webster, Duncan; Weis, Steve; Wheeler, David A; White, David J; Wilkins, Ed; Winston, Alan; Wlodaver, Clifford G; van't Wout, Angelique; Wright, David P; Yang, Otto O; Yurdin, David L; Zabukovic, Brandon W; Zachary, Kimon C; Zeeman, Beth; Zhao, Meng

    2010-12-10

    Infectious and inflammatory diseases have repeatedly shown strong genetic associations within the major histocompatibility complex (MHC); however, the basis for these associations remains elusive. To define host genetic effects on the outcome of a chronic viral infection, we performed genome-wide association analysis in a multiethnic cohort of HIV-1 controllers and progressors, and we analyzed the effects of individual amino acids within the classical human leukocyte antigen (HLA) proteins. We identified >300 genome-wide significant single-nucleotide polymorphisms (SNPs) within the MHC and none elsewhere. Specific amino acids in the HLA-B peptide binding groove, as well as an independent HLA-C effect, explain the SNP associations and reconcile both protective and risk HLA alleles. These results implicate the nature of the HLA-viral peptide interaction as the major factor modulating durable control of HIV infection.

  14. Application of Model Reference Adaptive Control System to Instrument Pointing System /IPS/

    NASA Technical Reports Server (NTRS)

    Waites, H. B.

    1979-01-01

    A Model Reference Adaptive Controller (MRAC) is derived for a Shuttle payload called the Instrument Pointing System (IPS). The unique features of this MRAC design are that total state feedback is not required, that the internal structure of the model is independent of the internal structure of the IPS, and that the model input is of bounded variation and not required a priori. An application of Liapunov's stability theorems is used to synthesize a control signal which assures MRAC asymptotic stability. Exponential observers are used to obtain the necessary state information to implement the control synthesis. Results are presented which show how effectively the MRAC can maneuver the IPS.

  15. Center manifold analysis of a point vortex model of vortex shedding with control

    NASA Astrophysics Data System (ADS)

    Protas, Bartosz

    2007-04-01

    In this paper we use methods of dynamical systems theory to provide a precise mathematical characterization of the behavior of the point vortex Föppl system with a linear feedback control. The Föppl system was used in an earlier investigation as a simple model for control design for vortex shedding and numerical studies indicated that the state of the controlled system converges to a closed orbit. In this investigation we prove rigorously that this observed behavior in fact represents periodic oscillations on the center manifold of the closed-loop nonlinear system. This manifold is shown to coincide with the uncontrollable subspace of the linearized system.

  16. Gate-controlled ballistic conductance of magnetic nanowires with double point contacts

    NASA Astrophysics Data System (ADS)

    Fallahi, V.

    2017-08-01

    Controlling the conductance and current flow through nanostructured magnetic point contacts is a key challenge for future spintronic devices. This could be achieved by exploiting the Rashba spin-orbit coupling effect induced by an external gate in the middle of two pinned domain walls at the point contacts. Here, I investigate the electrical conductance of a half-metallic diluted magnetic semiconductor nanowire with a double point contact exploitable in switching devices controlled by lateral gate voltage. The coherent quantum interference between forward- and backward-scattered waves in the spin quantum well formed by the double point contact leads to quasibound states with finite lifetimes. The energetic position of these quasibound states could be adjusted by the lateral gate voltage so that the incident energy coincides with one of the quasibound energy levels in the spin quantum well. Conductance calculations in the presence of an applied electric field perpendicular to the nanowire surface exhibit typical resonant tunneling behavior, where the nanostructure switches to the low-resistance ON state by tuning the Rashba coupling strength in the range of a few tens of meV nm. This study paves the way for utilizing the gate-controlled Rashba spin-orbit coupling effect to design and develop practical spintronic devices.

  17. Habit control during growth on GaN point seed crystals by Na-flux method

    NASA Astrophysics Data System (ADS)

    Honjo, Masatomo; Imanishi, Masayuki; Imabayashi, Hiroki; Nakamura, Kosuke; Murakami, Kosuke; Matsuo, Daisuke; Maruyama, Mihoko; Imade, Mamoru; Yoshimura, Masashi; Mori, Yusuke

    2017-01-01

    The formation of the pyramidal habit is one of the requirements for the dramatic reduction of dislocations during growth on a tiny GaN seed called a “point seed”. In this study, we focus on controlling the growth habit to form a pyramidal shape in order to reduce the number of dislocations in the c-growth sector during growth on GaN point seeds. High temperature growth was found to change the growth habit from the truncated pyramidal shape to the pyramidal shape. As a result, the number of dislocations in the c-growth sector tended to decrease with increasing growth temperature.

  18. SIM Lite Guide-2 telescope system identification, control design and pointing performance evaluation

    NASA Astrophysics Data System (ADS)

    Shields, Joel F.; Boussalis, Dhemetrio; Fathpour, Nanaz; Weilert, Mark; Hahn, Inseob; Ahmed, Asif

    2010-07-01

    The Guide-2 telescope (G2T) is an important subsystem of the new SIM Lite Astrometric Observatory. In this paper we present system identification experiments, design and implementation of the G2T stellar pointing loop that achieves milliarcsecond resolution of spacecraft attitude. Special emphasis was placed on characterization and modeling of PZT hysteresis since this nonlinearity plays an important part in the control loop performance. Power spectral densities of the star image centroids were use to evaluate the pointing loop performance with and with out the presence of simulated ACS disturbances injected via a fast steering mirror (FSM).

  19. Altered emotional interference processing in affective and cognitive-control brain circuitry in major depression

    PubMed Central

    Fales, Christina L.; Barch, Deanna M.; Rundle, Melissa M.; Mintun, Mark A.; Snyder, Abraham Z.; Cohen, Jonathan D.; Mathews, Jose; Sheline, Yvette I.

    2008-01-01

    Background Major depression is characterized by a negativity bias: an enhanced responsiveness to, and memory for, affectively negative stimuli. However it is not yet clear whether this bias represents (1) impaired top-down cognitive control over affective responses, potentially linked to deficits in dorsolateral prefrontal cortex function; or (2) enhanced bottom-up responses to affectively-laden stimuli that dysregulate cognitive control mechanisms, potentially linked to deficits in amygdala and anterior cingulate function. Methods We used an attentional interference task using emotional distracters to test for top-down versus bottom-up dysfunction in the interaction of cognitive-control circuitry and emotion-processing circuitry. A total of 27 patients with major depression and 24 controls were tested. Event-related functional magnetic resonance imaging was carried out as participants directly attended to, or attempted to ignore, fear-related stimuli. Results Compared to controls, patients with depression showed an enhanced amygdala response to unattended fear-related stimuli (relative to unattended neutral). By contrast, control participants showed increased activity in right dorsolateral prefrontal cortex (Brodmann areas 46/9) when ignoring fear stimuli (relative to neutral), which the patients with depression did not. In addition, the depressed participants failed to show evidence of error-related cognitive adjustments (increased activity in bilateral dorsolateral prefrontal cortex on post-error trials), but the control group did show them. Conclusions These results suggest multiple sources of dysregulation in emotional and cognitive control circuitry in depression, implicating both top-down and bottom-up dysfunction. PMID:17719567

  20. Using Fast-Steering Mirror Control to Reduce Instrument Pointing Errors Caused by Spacecraft Jitter

    NASA Technical Reports Server (NTRS)

    Antol, Jeffery; Holtz, Ted M.; Cuda, Vince; Johnson, Thomas A.

    1996-01-01

    The scope of this study was to investigate the benefit of using feedback control of a Fast Steering Mirror (FSM) to reduce instrument pointing errors. Initially, the study identified FSM control technologies and categorized them according to their use, range of applicability, and physical requirements. Candidate payloads were then evaluated according to their relevance in use of fast steering minor control technologies. This leads to the mission and instrument selection which served as the candidate mission for numerical modeling. A standard SmallSat was designed in order to accommodate the payload requirements (weight, size, power, etc.). This included sizing the SmallSat bus, sizing the solar array, choosing appropriate antennas, and identifying an attitude control system (ACS). A feedback control system for the FSM compensation was then designed, and the instrument pointing error and SmallSat jitter environment for open-loop and closed-loop FSM control were evaluated for typical SmallSat disturbances. The results were then compared to determine the effectiveness of the FSM feedback control system.

  1. A Globally Stable Lyapunov Pointing and Rate Controller for the Magnetospheric MultiScale Mission (MMS)

    NASA Technical Reports Server (NTRS)

    Shah, Neerav

    2011-01-01

    The Magnetospheric MultiScale Mission (MMS) is scheduled to launch in late 2014. Its primary goal is to discover the fundamental plasma physics processes of reconnection in the Earth's magnetosphere. Each of the four MMS spacecraft is spin-stabilized at a nominal rate of 3 RPM. Traditional spin-stabilized spacecraft have used a number of separate modes to control nutation, spin rate, and precession. To reduce the number of modes and simplify operations, the Delta-H control mode is designed to accomplish nutation control, spin rate control, and precession control simultaneously. A nonlinear design technique, Lyapunov's method, is used to design the Delta-H control mode. A global spin rate controller selected as the baseline controller for MMS, proved to be insufficient due to an ambiguity in the attitude. Lyapunov's design method was used to solve this ambiguity, resulting in a controller that meets the design goals. Simulation results show the advantage of the pointing and rate controller for maneuvers larger than 90 deg and provide insight into the performance of this controller.

  2. Double-blind, placebo-controlled evaluation of extended-release bupropion in elderly patients with major depressive disorder.

    PubMed

    Hewett, K; Chrzanowski, W; Jokinen, R; Felgentreff, R; Shrivastava, R K; Gee, M D; Wightman, D S; O'Leary, M C; Millen, L S; Leon, M C; Briggs, M A; Krishen, A; Modell, J G

    2010-04-01

    Major depressive disorder in the elderly is associated with increased morbidity and reduced quality of life. This 10 week, placebo-controlled study investigated the efficacy and tolerability of extended-release bupropion (150-300 mg once daily) in depressed patients aged 65 years or older. The statistical assumptions necessary for the validity of the protocol-specified analysis of covariance were not met for the analysis of the primary outcome variable (Montgomery-Asberg Depression Rating Scale total score at Week 10, last observation carried forward). Alternative statistical methods used for the analysis of this variable demonstrated statistical significance. Statistically significant improvements were observed on the majority of secondary end points when compared with placebo, including the health outcome measures for motivation and energy, and life satisfaction and contentment. Adverse events were generally mild to moderate and similar between treatment groups. This study demonstrated that the extended-release bupropion is an effective, well-tolerated treatment for major depression in the elderly.

  3. Geometric Calibration of ZIYUAN-3 Three-Line Cameras Combining Ground Control Points and Lines

    NASA Astrophysics Data System (ADS)

    Cao, Jinshan; Yuan, Xiuxiao; Gong, Jianya

    2016-06-01

    Due to the large biases between the laboratory-calibrated values of the orientation parameters and their in-orbit true values, the initial direct georeferencing accuracy of the Ziyuan-3 (ZY-3) three-line camera (TLC) images can only reach the kilometre level. In this paper, a point-based geometric calibration model of the ZY-3 TLCs is firstly established by using the collinearity constraint, and then a line-based geometric calibration model is established by using the coplanarity constraint. With the help of both the point-based and the line-based models, a feasible in-orbit geometric calibration approach for the ZY-3 TLCs combining ground control points (GCPs) and ground control lines (GCLs) is presented. Experimental results show that like GCPs, GCLs can also provide effective ground control information for the geometric calibration of the ZY-3 TLCs. The calibration accuracy of the look angles of charge-coupled device (CCD) detectors achieved by using the presented approach reached up to about 1.0''. After the geometric calibration, the direct georeferencing accuracy of the ZY-3 TLC images without ground controls was significantly improved from the kilometre level to better than 11 m in planimetry and 9 m in height. A more satisfactory georeferencing accuracy of better than 3.5 m in planimetry and 3.0 m in height was achieved after the block adjustment with four GCPs.

  4. PointCom: semi-autonomous UGV control with intuitive interface

    NASA Astrophysics Data System (ADS)

    Rohde, Mitchell M.; Perlin, Victor E.; Iagnemma, Karl D.; Lupa, Robert M.; Rohde, Steven M.; Overholt, James; Fiorani, Graham

    2008-04-01

    Unmanned ground vehicles (UGVs) will play an important role in the nation's next-generation ground force. Advances in sensing, control, and computing have enabled a new generation of technologies that bridge the gap between manual UGV teleoperation and full autonomy. In this paper, we present current research on a unique command and control system for UGVs named PointCom (Point-and-Go Command). PointCom is a semi-autonomous command system for one or multiple UGVs. The system, when complete, will be easy to operate and will enable significant reduction in operator workload by utilizing an intuitive image-based control framework for UGV navigation and allowing a single operator to command multiple UGVs. The project leverages new image processing algorithms for monocular visual servoing and odometry to yield a unique, high-performance fused navigation system. Human Computer Interface (HCI) techniques from the entertainment software industry are being used to develop video-game style interfaces that require little training and build upon the navigation capabilities. By combining an advanced navigation system with an intuitive interface, a semi-autonomous control and navigation system is being created that is robust, user friendly, and less burdensome than many current generation systems. mand).

  5. Assessment of hygiene standards and Hazard Analysis Critical Control Points implementation on passenger ships.

    PubMed

    Mouchtouri, Varavara; Malissiova, Eleni; Zisis, Panagiotis; Paparizou, Evina; Hadjichristodoulou, Christos

    2013-01-01

    The level of hygiene on ferries can have impact on travellers' health. The aim of this study was to assess the hygiene standards of ferries in Greece and to investigate whether Hazard Analysis Critical Control Points (HACCP) implementation contributes to the hygiene status and particularly food safety aboard passenger ships. Hygiene inspections on 17 ferries in Greece were performed using a standardized inspection form, with a 135-point scale. Thirty-four water and 17 food samples were collected and analysed. About 65% (11/17) of ferries were scored with >100 points. Ferries with HACCP received higher scores during inspection compared to those without HACCP (p value <0.001). All 34 microbiological water test results were found negative and, from the 17 food samples, only one was found positive for Salmonella spp. Implementation of management systems including HACCP principles can help to raise the level of hygiene aboard passenger ships.

  6. Low-boiling-point solvent additives can also enable morphological control in polymer solar cells

    SciTech Connect

    Mahadevapuram, Rakesh C.; Carr, John A.; Chen, Yuqing; Bose, Sayantan; Nalwa, Kanwar S.; Petrich, Jacob W.; Chaudhary, Sumit

    2013-11-02

    Processing organic photovoltaic (OPV) blend solutions with high-boiling-point solvent additives has recently been used for morphological control in bulk-heterojunction OPV cells. Here we show that even low-boiling-point solvents can be effective additives. When P3HT:PCBM OPV cells were processed with a low-boiling-point solvent tetrahydrafuran as an additive in parent solvent o-dichlorobenzene, charge extraction increased leading to fill factors as high as 69.5%, without low work-function cathodes, electrode buffer layers or thermal treatment. This was attributed to PCBM demixing from P3HT domains and better vertical phase separation, as indicated by photoluminescence lifetimes, hole mobilities, and shunt leakage currents. Dependence on solvent parameters and applicability beyond P3HT system was also investigated. (C) 2013 Elsevier B.V. All rights reserved.

  7. Initial experiments on the end-point control of a flexible one-link robot

    NASA Technical Reports Server (NTRS)

    Cannon, R. H., Jr.; Schmitz, E.

    1984-01-01

    The present investigation is concerned with initial experiments regarding a specific unsolved control problem which appeared to be central to advances in the art of robotics. This problem involves the control of a flexible member (one link of a robot system). The position of the end-effector, called the end point or tip, is controlled by measuring that position and using the measurement as a basis for applying control torque to the other end of the flexible member, as for instance, the robot's elbow joint. A description is presented of the features of the first experimental arm which has been made, and an outline is provided of the general strategy for controlling it using its tip sensor and shoulder torquer.

  8. Initial experiments on the end-point control of a flexible one-link robot

    NASA Technical Reports Server (NTRS)

    Cannon, R. H., Jr.; Schmitz, E.

    1984-01-01

    The present investigation is concerned with initial experiments regarding a specific unsolved control problem which appeared to be central to advances in the art of robotics. This problem involves the control of a flexible member (one link of a robot system). The position of the end-effector, called the end point or tip, is controlled by measuring that position and using the measurement as a basis for applying control torque to the other end of the flexible member, as for instance, the robot's elbow joint. A description is presented of the features of the first experimental arm which has been made, and an outline is provided of the general strategy for controlling it using its tip sensor and shoulder torquer.

  9. Loop Heat Pipe Operation Using Heat Source Temperature for Set Point Control

    NASA Technical Reports Server (NTRS)

    Ku, Jentung; Paiva, Kleber; Mantelli, Marcia

    2011-01-01

    The LHP operating temperature is governed by the saturation temperature of its reservoir. Controlling the reservoir saturation temperature is commonly accomplished by cold biasing the reservoir and using electrical heaters to provide the required control power. Using this method, the loop operating temperature can be controlled within +/- 0.5K. However, because of the thermal resistance that exists between the heat source and the LHP evaporator, the heat source temperature will vary with its heat output even if LHP operating temperature is kept constant. Since maintaining a constant heat source temperature is of most interest, a question often raised is whether the heat source temperature can be used for LHP set point temperature control. A test program with a miniature LHP has been carried out to investigate the effects on the LHP operation when the control temperature sensor is placed on the heat source instead of the reservoir. In these tests, the LHP reservoir is cold-biased and is heated by a control heater. Tests results show that it is feasible to use the heat source temperature for feedback control of the LHP operation. Using this method, the heat source temperature can be maintained within a tight range for moderate and high powers. At low powers, however, temperature oscillations may occur due to interactions among the reservoir control heater power, the heat source mass, and the heat output from the heat source. In addition, the heat source temperature could temporarily deviate from its set point during fast thermal transients. The implication is that more sophisticated feedback control algorithms need to be implemented for LHP transient operation when the heat source temperature is used for feedback control.

  10. Model, control and performance of a six degree-of-freedom precision pointing and tracking system

    NASA Astrophysics Data System (ADS)

    Ren, Zhaohui

    In this dissertation, a six degree-of-freedom (6-DOF) precision pointing and tracking system is integrated to demonstrate its laser pointing and tracking capability in ambient laboratory environment. Such a demonstration is intended for potential high accuracy pointing and smooth angular slewing applications in space, such as free-space laser communications among satellites. The key technology adopted is the slotless permanent magnet (PM) self-bearing motor (SBM), which is first utilized to fully provide radial bearing and motoring functionality simultaneously in a novel 6-DOF magnetic actuator. The precision actuator incorporates two SBMs and one active magnetic bearing (AMB), and thus allows for a complete electromagnetic suspension and precision non-contact pointing. The sensing scheme is critical to the feedback control of the open loop unstable magnetic actuator. Among various sensors used, the unique linear tape encoding strategy uses the same concept as in the SBM and provides high resolution and non-contact measurement for radial and angular displacements simultaneously. To accurately characterize current and negative stiffness gains in the linearized force-current-displacement relation of the large-scale SBM, the analytical force and torque expressions are derived using the Maxwell stress tensor method. A general two-dimensional (2-D) magnetic field analysis in the large effective air gap is conducted and the field components due to thick windings and PMs are formulated in explicit forms. All analytical solutions are validated by the electromagnetic finite element analyses (FEA). An analytical representation of the overall dynamic system is presented for linear controller design. Six decoupled proportional-integral-derivative (PID) controllers are designed and a real-time digital feedback control system is implemented. Intensive experiments are carried out to evaluate the closed loop performance. The actuator is capable of smooth angular slewing while

  11. Major Autonomic Neuroregulatory Pathways Underlying Short- and Long-Term Control of Cardiovascular Function.

    PubMed

    Salman, Ibrahim M

    2016-03-01

    Short-term and long-term blood pressure (BP) regulation and its maintenance at levels adequate to perfuse tissue organs involve an integrated action of multiple neural, cardiovascular, renal, endocrine and local tissue control systems. In the recent year, there has been a growing interest in the understanding of neural pathways key to BP control. For instance, through major advances in studies using both anesthetized and conscious animals, our knowledge of the essential neural mechanisms that subserve the baroreceptor, cardiopulmonary and chemoreceptor reflexes, and those evoked by the activation of stress pathways has dramatically increased. While the importance of these neural pathways in the maintenance of cardiovascular homeostasis is well established, the recognition of the central processing nuclei that integrate various afferent inputs to produce synchronous adjustments of autonomic outflows is still progressively expanding. Based on the literature provided thus far, the present review provides an overview in relation to the important neural determinants of BP control and later offers a concise description of major neuronal pathways that control autonomic outflows to the cardiovascular system in the short and long term.

  12. Design of set-point weighting PIλ + Dμ controller for vertical magnetic flux controller in Damavand tokamak.

    PubMed

    Rasouli, H; Fatehi, A

    2014-12-01

    In this paper, a simple method is presented for tuning weighted PI(λ) + D(μ) controller parameters based on the pole placement controller of pseudo-second-order fractional systems. One of the advantages of this controller is capability of reducing the disturbance effects and improving response to input, simultaneously. In the following sections, the performance of this controller is evaluated experimentally to control the vertical magnetic flux in Damavand tokamak. For this work, at first a fractional order model is identified using output-error technique in time domain. For various practical experiments, having desired time responses for magnetic flux in Damavand tokamak, is vital. To approach this, at first the desired closed loop reference models are obtained based on generalized characteristic ratio assignment method in fractional order systems. After that, for the identified model, a set-point weighting PI(λ) + D(μ) controller is designed and simulated. Finally, this controller is implemented on digital signal processor control system of the plant to fast/slow control of magnetic flux. The practical results show appropriate performance of this controller.

  13. Akara Ogbomoso: microbiological examination and identification of hazards and critical control points.

    PubMed

    Lateef, A; Davies, T E; Adelekan, A; Adelere, I A; Adedeji, A A; Fadahunsi, A H

    2010-10-01

    Akara Ogbomoso was examined toward the establishment of hazard analysis and critical control point (HACCP). The akara was produced in residential buildings with the attendant consequence of contamination. There was ample growth of aerobes, coliforms, staphylococci, Shigella and yeast/mold from the samples, water and cowpea pastes. Microbial contaminations occur through the processing, which can be corrected through education by adopting good hygienic and manufacturing practices. The critical control points were identified as frying, storage and refrying. It may be heated in the microwave for 10 s before consumption. Akara, prepared in the laboratory through the implementation of HACCP was not contaminated. Several bacterial isolates, namely; Escherichia coli, Staphylococcus aureus, Staphylococcus epidermidis, Citrobacter freundii, Serratia marcescens, Proteus vulgaris, Bacillus cereus, Streptococcus pyogenes, Bacillus sp. and Shigella sp., showed multiple resistance to antibiotics ranging from two to nine. Seven strains were not resistant to the antibiotics, while five were resistant to one type of antibiotic.

  14. Realworld maximum power point tracking simulation of PV system based on Fuzzy Logic control

    NASA Astrophysics Data System (ADS)

    Othman, Ahmed M.; El-arini, Mahdi M. M.; Ghitas, Ahmed; Fathy, Ahmed

    2012-12-01

    In the recent years, the solar energy becomes one of the most important alternative sources of electric energy, so it is important to improve the efficiency and reliability of the photovoltaic (PV) systems. Maximum power point tracking (MPPT) plays an important role in photovoltaic power systems because it maximize the power output from a PV system for a given set of conditions, and therefore maximize their array efficiency. This paper presents a maximum power point tracker (MPPT) using Fuzzy Logic theory for a PV system. The work is focused on the well known Perturb and Observe (P&O) algorithm and is compared to a designed fuzzy logic controller (FLC). The simulation work dealing with MPPT controller; a DC/DC Ćuk converter feeding a load is achieved. The results showed that the proposed Fuzzy Logic MPPT in the PV system is valid.

  15. Bounded trajectories near collinear-like equilibrium points of elongated asteroids using linear control

    NASA Astrophysics Data System (ADS)

    Yang, Hongwei; Baoyin, Hexi; Bai, Xiaoli; Li, Jingyang

    2017-02-01

    A new method of obtaining bounded trajectories near collinear-like equilibrium points of elongated asteroids using a simple linear control is proposed. The characteristic equation of the linearized equation of motion near the collinear-like equilibrium points is reduced based on the property of the second derivatives of the effective potential. According to the reduced characteristic equation, the motion is decoupled into an in-plane motion and a out-of-plane motion. The solutions to the decoupled equation of motion are derived and the corresponding Lissajous trajectories are chosen as desired trajectories. A simple linear control, which tracks the Lissajous trajectories, is formulated with the stability conditions of gains. The effectiveness of the proposed method is validated by simulations using high fidelity models of 216 Kleopatra and 951 Gaspra.

  16. Model reference adaptive control for the azimuth-pointing system of a balloon-borne stabilized platform

    NASA Technical Reports Server (NTRS)

    Lubin, Philip M.; Tomizuka, Masayoshi; Chingcuanco, Alfredo O.; Meinhold, Peter R.

    1991-01-01

    A balloon-born stabilized platform has been developed for the remotely operated altitude-azimuth pointing of a millimeter wave telescope system. This paper presents a development and implementation of model reference adaptive control (MRAC) for the azimuth-pointing system of the stabilized platform. The primary goal of the controller is to achieve pointing rms better than 0.1 deg. Simulation results indicate that MRAC can achieve pointing rms better than 0.1 deg. Ground test results show pointing rms better than 0.03 deg. Data from the first flight at the National Scientific Balloon Facility (NSBF) Palestine, Texas show pointing rms better than 0.02 deg.

  17. Hazard analysis and critical control point systems in the United States Department of Agriculture regulatory policy.

    PubMed

    Billy, T J; Wachsmuth, I K

    1997-08-01

    Recent outbreaks of foodborne illness and studies by expert groups have established the need for fundamental change in the United States meat and poultry inspection programme to reduce the risk of foodborne illness. The Food Safety and Inspection Service (FSIS) of the United States Department of Agriculture (USDA) has embarked on a broad effort to bring about such change, with particular emphasis on the reduction of pathogenic micro-organisms in raw meat and poultry products. The publication on 25 July 1996 of the Final Rule on pathogen reduction and hazard analysis and critical control point (HACCP) systems was a major milestone in the FSIS strategy for change. The Final Rule provides a framework for change and clarifies the respective roles of industry and government in ensuring the safety of meat and poultry products. With the implementation of this Final Rule underway, the FSIS has been exploring ways in which slaughter inspection carried out under an HACCP-based system can be changed so that food safety risks are addressed more adequately and the allocation of inspection resources is improved further. In addition, the FSIS is broadening the focus of food safety activities to extend beyond slaughter and processing plants by working with industry, academia and other government agencies. Such co-operation should lead to the development of measures to improve food safety before animals reach the slaughter plant and after products leave the inspected establishment for distribution to the retail level. For the future, the FSIS believes that quantitative risk assessments will be at the core of food safety activities. Risk assessments provide the most effective means of identifying how specific pathogens and other hazards may be encountered throughout the farm-to-table chain and of measuring the potential impact of various interventions. In addition, these assessments will be used in the development and evaluation of HACCP systems. The FSIS is currently conducting a

  18. Coordinated control of tethered space robot using mobile tether attachment point in approaching phase

    NASA Astrophysics Data System (ADS)

    Wang, Dongke; Huang, Panfeng; Cai, Jia; Meng, Zhongjie

    2014-09-01

    Tethered space robots (TSRs) have wide applications in future on-orbit service owing to its flexibility and great workspace. However, the control problem is quite complex and difficult in the phase of approaching target, and the fuel consumption must also be taken into account. Hence, we present a novel scheme of achieving coordinated orbit and attitude control simultaneously for the TSR. Space tether, which can provide greater force compared with the thruster force, is used in the design of the orbit and attitude coordinated controller. A coordinated control mechanism is designed to provide attitude control torques of the pitch and yaw motions by adjusting the position of the mobile tether attachment point, while the roll motion is stabilized by the thruster. In order to guarantee this mechanism to work properly, constant tether tension strategies are utilized to plan an optimal approaching trajectory which is tracked by the coordinated controller of tether force and thruster force. Numerical simulation validates the feasibility of our proposed coordinated control scheme for TSR in the approaching phase. Furthermore, fuel consumption of the orbit and attitude control are both significantly reduced compared with traditional thruster control.

  19. Synergies in the space of control variables within the equilibrium-point hypothesis

    PubMed Central

    Ambike, Satyajit; Mattos, Daniela; Zatsiorsky, Vladimir M.; Latash, Mark L.

    2015-01-01

    We use an approach rooted in the recent theory of synergies to analyze possible co-variation between two hypothetical control variables involved in finger force production based in the equilibrium-point hypothesis. These control variables are the referent coordinate (R) and apparent stiffness (C) of the finger. We tested a hypothesis that inter-trial co-variation in the {R; C} space during repeated, accurate force production trials stabilizes the fingertip force. This was expected to correspond to a relatively low amount of inter-trial variability affecting force and a high amount of variability keeping the force unchanged. We used the “inverse piano” apparatus to apply small and smooth positional perturbations to fingers during force production tasks. Across trials, R and C showed strong co-variation with the data points lying close to a hyperbolic curve. Hyperbolic regressions accounted for over 99% of the variance in the {R; C} space. Another analysis was conducted by randomizing the original {R; C} data sets and creating surrogate data sets that were then used to compute predicted force values. The surrogate sets always showed much higher force variance compared to the actual data, thus reinforcing the conclusion that finger force control was organized in the {R; C} space, as predicted by the equilibrium-point hypothesis, and involved co-variation in that space stabilizing total force. PMID:26701299

  20. Critical control points of complementary food preparation and handling in eastern Nigeria.

    PubMed Central

    Ehiri, J. E.; Azubuike, M. C.; Ubbaonu, C. N.; Anyanwu, E. C.; Ibe, K. M.; Ogbonna, M. O.

    2001-01-01

    OBJECTIVE: To investigate microbial contamination and critical control points (CCPs) in the preparation and handling of complementary foods in 120 households in Imo state, Nigeria. METHODS: The Hazard Analysis Critical Control Point (HACCP) approach was used to investigate processes and procedures that contributed to microbial contamination, growth and survival, and to identify points where controls could be applied to prevent or eliminate these microbiological hazards or reduce them to acceptable levels. Food samples were collected and tested microbiologically at different stages of preparation and handling. FINDINGS: During cooking, all foods attained temperatures capable of destroying vegetative forms of food-borne pathogens. However, the risk of contamination increased by storage of food at ambient temperature, by using insufficiently high temperatures to reheat the food, and by adding contaminated ingredients such as dried ground crayfish and soybean powder at stages where no further heat treatment was applied. The purchasing of contaminated raw foodstuffs and ingredients, particularly raw akamu, from vendors in open markets is also a CCP. CONCLUSION: Although an unsafe environment poses many hazards for children's food, the hygienic quality of prepared food can be assured if basic food safety principles are observed. When many factors contribute to food contamination, identification of CCPs becomes particularly important and can facilitate appropriate targeting of resources and prevention efforts. PMID:11417038

  1. Effect of acupressure at the Sanyinjiao point on primary dysmenorrhea: a randomized controlled trial.

    PubMed

    Kashefi, Farzaneh; Ziyadlou, Samaneh; Khajehei, Marjan; Ashraf, Ali Reza; Fadaee, Ali Reza; Jafari, Peyman

    2010-11-01

    We conducted this study to assess the effect of acupressure at the Sanyinjiao point on primary dysmenorrhea. Eighty-six students participated in the study. All participants met the inclusion criteria. The study group received acupressure at Sanyinjiao point, while the control received sham acupressure. The severity of dysmenorrhea was assessed at the following time periods: prior to the intervention, 30 min, 1, 2 and 3h following the intervention. Data were analyzed using SPSS. The acupressure caused decline in the severity of dysmenorrhea immediately after intervention in both groups during their first menstrual cycle, although, there difference was not significant (p>0.05). In addition, during the same cycle, the severity of the dysmenorrhea decreased more in study group rather than control group at 30 min, 1, 2 and 3h after intervention (p<0.05). During the second menstrual cycle, acupressure made dysmenorrhea reduced in both study and control groups; however, the decline was more salient among participants of the study group at all stages after the intervention (p<0.05). Acupressure at Sanyinjiao point can be an effective, feasible, cost-effective intervention for improving primary dysmenorrhea. Copyright © 2010 Elsevier Ltd. All rights reserved.

  2. Eigensensitivity in integrated design. [of earth-pointing satellite's control system

    NASA Technical Reports Server (NTRS)

    Kenny, Sean P.; Hou, Gene J.; Belvin, W. K.

    1990-01-01

    An application of eigensensitivity analysis to the control-structure integrated design process is presented with an emphasis placed on computational efficiency improvement of the overall design optimization process. The computational efficiency of eigenvalue/vector sensitivity analysis is demonstrated using the Earth Pointing Satellite in the context of a control-structure integrated design program. Results for a 2 percent design variable perturbation with and without the effects of the actuator mass show a 42 and 52 percent reduction in CPU time, respectively.

  3. Chaos control in a chaotic system with only one stable equilibrium point

    NASA Astrophysics Data System (ADS)

    Buscarino, Arturo; Fortuna, Luigi; Frasca, Mattia; Gambuzza, Lucia Valentina; Pham, Thanh Viet

    2012-09-01

    The recent finding on the effect of a small bias in Sprott-like systems, i.e., the stabilization of the unstable equilibrium point through the addition of a small bias [1], paves the way to efficient methods for chaos control in such systems. In this work, we investigate the control of one of such systems both in the ideal case of absence of noise and in the presence of noise. We then propose an experimental setup for the experimental verification of the introduced method.

  4. Feedback controlled electromigration for the fabrication of point contacts and noise measurement applications

    NASA Astrophysics Data System (ADS)

    Campbell, Jennifer Maureen

    Lithographically fabricated point contacts serve as important examples of mesoscopic conductors, as electrodes for molecular electronics, and as ultra-sensitive transducers for mechanical motion. We have developed a reproducible technique for fabricating metallic point contacts through electromigration. We employ fast analog feedback in a four-wire configuration in combination with slower computer controlled feedback to avoid catastrophic instability even when there is significant series resistance. This hybrid system allows electromigration to proceed while dissipating approximately constant power in the wire. We are able to control the final resistance of the point contact precisely below 5 kO and to within a factor of three when the target resistance approaches 12 kO where only a single conducting channel remains. This system makes it possible to efficiently create point contacts through electromigration for fundamental studies of atomic-size conductors or applications such as displacement transducers. As an application of the hybrid feedback system for forming point contacts, we have developed a low-temperature, high-frequency noise measurement system. The system, which operates from 0.8 to 1.5 GHz at temperatures as low as 320 mK, takes advantage of impedance matching techniques to improve power transfer by up to 65%. This is accomplished by combining an inductor with unavoidable stray capacitance to form a resonant LC circuit. Noise measurement tests with a photodiode-LED pair at room temperature demonstrated the ability to resolve shot noise down to 5 x 10--26 A 2/Hz. This corresponds to the shot noise of 155 nA through a single channel point contact. We designed and fabricated an aluminum superconducting planar inductor coupled to a gold point contact wire to test the noise measurement system at ultra-low temperatures. Finite element simulations suggested that the inductor may not be superconducting at the onset of electromigration but the study was not

  5. Human factors aspects of the major upgrade to the control systems at the LANL plutonium facility

    SciTech Connect

    Higgins, J.C.; Pope, N.

    1997-04-01

    The Plutonium Facility (TA-55) at Los Alamos National Laboratory (LANL) has been in operation for almost 20 years. The Operations Center of TA-55 is the nerve center of the facility where operators are on duty around the clock and monitor several thousand data points using the Facility Control System (FCS). The FCS monitors, displays, alarms, and provides some limited control of several systems, including: HVAC, fire detection and suppression, radiation detection, and electrical. The FCS was failing and needed to be replaced expeditiously. This paper will discuss the human factors aspects of the design, installation, and testing of the new FCS within the above noted constraints. Particular items to be discussed include the functional requirements definition, operating experience review, screen designs, test program, operator training, and phased activation of the new circuits in an operational facility.

  6. Optimal control of a spinning double-pyramid Earth-pointing tethered formation

    NASA Astrophysics Data System (ADS)

    Williams, Paul

    2009-06-01

    The dynamics and control of a tethered satellite formation for Earth-pointing observation missions is considered. For most practical applications in Earth orbit, a tether formation must be spinning in order to maintain tension in the tethers. It is possible to obtain periodic spinning solutions for a triangular formation whose initial conditions are close to the orbit normal. However, these solutions contain significant deviations of the satellites on a sphere relative to the desired Earth-pointing configuration. To maintain a plane of satellites spinning normal to the orbit plane, it is necessary to utilize "anchors". Such a configuration resembles a double-pyramid. In this paper, control of a double-pyramid tethered formation is studied. The equations of motion are derived in a floating orbital coordinate system for the general case of an elliptic reference orbit. The motion of the satellites is derived assuming inelastic tethers that can vary in length in a controlled manner. Cartesian coordinates in a rotating reference frame attached to the desired spin frame provide a simple means of expressing the equations of motion, together with a set of constraint equations for the tether tensions. Periodic optimal control theory is applied to the system to determine sets of controlled periodic trajectories by varying the lengths of all interconnecting tethers (nine in total), as well as retrieval and simple reconfiguration trajectories. A modal analysis of the system is also performed using a lumped mass representation of the tethers.

  7. Development of safe mechanism for surgical robots using equilibrium point control method.

    PubMed

    Park, Shinsuk; Lim, Hokjin; Kim, Byeong-sang; Song, Jae-bok

    2006-01-01

    This paper introduces a novel mechanism for surgical robotic systems to generate human arm-like compliant motion. The mechanism is based on the idea of the equilibrium point control hypothesis which claims that multi-joint limb movements are achieved by shifting the limbs' equilibrium positions defined by neuromuscular activity. The equilibrium point control can be implemented on a robot manipulator by installing two actuators at each joint of the manipulator, one to control the joint position, and the other to control the joint stiffness. This double-actuator mechanism allows us to arbitrarily manipulate the stiffness (or impedance) of a robotic manipulator as well as its position. Also, the force at the end-effector can be estimated based on joint stiffness and joint angle changes without using force transducers. A two-link manipulator and a three-link manipulator with the double-actuator units have been developed, and experiments and simulation results show the potential of the proposed approach. By creating the human arm-like behavior, this mechanism can improve the performance of robot manipulators to execute stable and safe movement in surgical environments by using a simple control scheme.

  8. [Zoning planning in non-point source pollution control in Hanyang district].

    PubMed

    Yang, Liu; Ma, Ke-Ming; Guo, Qing-Hai; Zhao, Jing-Zhu; Luo, Yong-Feng

    2006-01-01

    It is most important for managing urban non-point source (NPS) pollution, actualizing the urban sustainable development as well, that zoning planning of urban NPS pollution control is studied. A case study on principles and methods of zoning planning in urban NPS pollution is carried out. Principles of urban sustainable development, priority of urban NPS pollution sensitivity, similarity of urban NPS control direction and region conjugate are put forward. Besides, it is for the first time that a more quantitive method is presented, in the case of Hanyang district, Wuhan city, which is based on L-THIA model and spatial analysis technique in GIS. Assessment of NPS pollution status quo, as well as analysis of NPS sensitivity, is the kernel component of the quantitive method. Hanyang might be divided into four NPS pollution control zones. It is helpful for decision-making of regional NPS pollution control.

  9. Dithering Digital Ripple Correlation Control for Photovoltaic Maximum Power Point Tracking

    SciTech Connect

    Barth, C; Pilawa-Podgurski, RCN

    2015-08-01

    This study demonstrates a new method for rapid and precise maximum power point tracking in photovoltaic (PV) applications using dithered PWM control. Constraints imposed by efficiency, cost, and component size limit the available PWM resolution of a power converter, and may in turn limit the MPP tracking efficiency of the PV system. In these scenarios, PWM dithering can be used to improve average PWM resolution. In this study, we present a control technique that uses ripple correlation control (RCC) on the dithering ripple, thereby achieving simultaneous fast tracking speed and high tracking accuracy. Moreover, the proposed method solves some of the practical challenges that have to date limited the effectiveness of RCC in solar PV applications. We present a theoretical derivation of the principles behind dithering digital ripple correlation control, as well as experimental results that show excellent tracking speed and accuracy with basic hardware requirements.

  10. Control of cutaneous leishmaniasis caused by Leishmania major in south-eastern Morocco.

    PubMed

    Bennis, Issam; De Brouwere, Vincent; Ameur, Btissam; El Idrissi Laamrani, Abderrahmane; Chichaoui, Smaine; Hamid, Sahibi; Boelaert, Marleen

    2015-10-01

    The incidence of cutaneous leishmaniasis (CL) caused by Leishmania major has increased in Morocco over the last decade, prompting the Ministry of Health to take intersectoral response measures including vector and reservoir control. The aim of this article was to describe the CL outbreak response measures taken in the province of Errachidia, where the reservoir of L. major, a sand rat (Meriones shawi), was targeted using strychnine-poisoned wheat baits from 2010 to 2012. We analysed routine surveillance data and other information using the data of the CL control programme. We present data on the evolution and the extension of CL in this province as well as the epidemiological profile of the disease. Between 2004 and 2013, 7099 cases of CL were recorded in Errachidia Province, gradually affecting all districts. Our results demonstrate that more women were affected than men and that all age groups were represented. Errachidia Province was the epicentre of the recent CL outbreak in Morocco. A notable decline in incidence rates was observed after 2011. The outbreak control measures may have contributed to this decline, as well as climatic trends or progressing herd immunity. © 2015 John Wiley & Sons Ltd.

  11. The HLA-B/-C haplotype block contains major determinants for host control of HIV

    PubMed Central

    Trachtenberg, E; Bhattacharya, T; Ladner, M; Phair, J; Erlich, H; Wolinsky, S

    2010-01-01

    A genome-wide association study of people with incident human immunodeficiency virus (HIV) infection selected from nine different cohorts identified allelic polymorphisms, which associated with either viral set point (HCP5 and 5′ HLA-C) or with HIV disease progression (RNF39 and ZNRD1). To determine the influence of these polymorphisms on host control of HIV, we carried out a population-based association study. The analysis revealed complete linkage disequilibrium between HCP5 and HLA-B*5701/HLA-Cw*06, a modest effect of 5′ HLA-C on viral set point in the absence of HLA-B*5701, and no influence of the RNF39 /ZNRD1 extended haplotype on HIV disease progression. No correlation was found between the infection status and any of these genetic variants (P>0.1, Fisher's exact test). These findings suggest a pattern of strong linkage disequilibrium consistent with an HLA-B/-C haplotype block, making identification of a causal variant difficult, and underscore the importance of validating polymorphisms in putative determinants for host control by association analysis of independent populations. PMID:19693088

  12. Immune response genes controlling responsiveness to major transplantation antigens. Specific major histocompatibility complex-linked defect for antibody responses to class I alloantigens

    SciTech Connect

    Butcher, G.W.; Corvalan, J.R.; Licence, D.R.; Howard, J.C.

    1982-01-01

    We have identified two major histocompatibility complex (MHC)-linked Ir genes that control the antibody response made by rats against class I major alloantigens. We have named these genes Ir-RT1Aa and Ir-RT1Ac. These Ir genes determine responsiveness of the immunized animal in a typical codominant fashion. There is no evidence so far for trans-complementation between low-responder haplotypes. Detailed studies of Ir-RT1Aa indicate that it controls the antibody response to at least two distinct alloantigenic determinants on RT1Aa molecules. These class I molecules thus behave like hapten-carrier conjugates when the response against the carrier is under Ir gene control. Analysis of the origin of alloantibody-forming cells in tetraparental radiation chimeras indicates that Ir-RT1Aa must control the provision of effective help to B cells. In many respects therefore, the properties of Ir-RT1Aa are broadly similar to those described for Ir genes controlling antibody responses to conventional antigens. The existence of apparently conventional Ir genes controlling the antibody response to major alloantigens strongly suggest that the processing of these transmembrane molecules by host antigen-presenting cells is a prerequisite for immune induction, and that it is the MHC of the responder rather than that of the allograft to which T helper cells are restricted in alloimmune responses in vivo.

  13. Integrated watershed approach in controlling point and non-point source pollution within Zelivka drinking water reservoir.

    PubMed

    Holas, J; Hrncir, M

    2002-01-01

    An agricultural watershed involves manipulation of soil, water and other natural resources and it has profound impacts on ecosystems. To manage these complex issues, we must understand causes and consequences and interactions-related transport of pollutants, quality of the environment, mitigation measures and policy measures. A ten year period of economic changes has been analysed with respect to sustainable development concerning Zelivka drinking water reservoir and its watershed, where agriculture and forestry are the main human activities. It is recommended that all land users within a catchment area should receive payments for their contribution to water cycle management. Setting up the prevention principles and best management practices financially subsidized by a local water company has been found very effective in both point and non-point source pollution abatement, and the newly prepared Clean Water Programme actively involves local municipal authorities as well. The first step based on systems analysis was to propose effective strategies and select alternative measures and ways for their financing. Long term monitoring of nutrient loads entering the reservoir and hazardous events statistics resulted in maps characterising the territory including vulnerable zones and risk factors. Financing involves providing annual payments to farmers, who undertake to manage specified areas of their land in a particular way and one-off payments to realise proposed issues ensuring soil conservation and watershed ecosystem benefits.

  14. Testing of an End-Point Control Unit Designed to Enable Precision Control of Manipulator-Coupled Spacecraft

    NASA Technical Reports Server (NTRS)

    Montgomery, Raymond C.; Ghosh, Dave; Tobbe, Patrick A.; Weathers, John M.; Manouchehri, Davoud; Lindsay, Thomas S.

    1994-01-01

    This paper presents an end-point control concept designed to enable precision telerobotic control of manipulator-coupled spacecraft. The concept employs a hardware unit (end-point control unit EPCU) that is positioned between the end-effector of the Space Shuttle Remote Manipulator System and the payload. Features of the unit are active compliance (control of the displacement between the end-effector and the payload), to allow precision control of payload motions, and inertial load relief, to prevent the transmission of loads between the end-effector and the payload. This paper presents the concept and studies the active compliance feature using a simulation and hardware. Results of the simulation show the effectiveness of the EPCU in smoothing the motion of the payload. Results are presented from initial, limited tests of a laboratory hardware unit on a robotic arm testbed at the l Space Flight Center. Tracking performance of the arm in a constant speed automated retraction and extension maneuver of a heavy payload with and without the unit active is compared for the design speed and higher speeds. Simultaneous load reduction and tracking performance are demonstrated using the EPCU.

  15. Research on automatic optimization of ground control points in image geometric rectification based on Voronoi diagram

    NASA Astrophysics Data System (ADS)

    Li, Ying; Cheng, Bo

    2009-10-01

    With the development of remote sensing satellites, the data quantity of remote sensing image is increasing tremendously, which brings a huge workload to the image geometric rectification through manual ground control point (GCP) selections. GCP database is one of the effective methods to cut down manual operation. The GCP loaded from database is generally redundant, which may result in a rectification slowdown. How to automatically optimize these ground control points is a problem that should be resolved urgently. According to the basic theory of geometric rectification and the principle of GCP selection, this paper deeply comprehends some existing methods about automatic optimization of GCP, and puts forward a new method of automatic optimization of GCP based on voronoi diagram to filter ground control points from the overfull ones without manual subjectivity for better accuracy. The paper is organized as follows: First, it clarifies the basic theory of remote sensing image multinomial geometric rectification and the arithmetic of how to get the GCP error. Second, it particularly introduces the voronoi diagram including its origin, development and characteristics, especially the creating process. Third, considering the deficiencies of existing methods about automatic optimization of GCP, the paper presents the idea of applying voronoi diagram to filter GCP in order to complete automatic optimization. During this process, it advances the conception of single GCP's importance value based on voronoi diagram. Then by integrating the GCP error and GCP's importance value, the paper gives the theory and the flow of automatic optimization of GCPs as well. It also presents an example of the application of this method. In the conclusion, it points out the advantages of automatic optimization of GCP based on the voronoi diagram.

  16. Subliminal psychodynamic activation: an experiment controlling for major possible confounding influences outlined by Fudin.

    PubMed

    Gustafson, R; Källmén, H

    1991-08-01

    40 and 48 subjects participated in two separate experiments aimed at reproducing the subliminal psychodynamic activation (SPA) phenomenon and taking into account the major methodological critique by Fudin (1986, 1990). Subjects were first exposed either to a full or one of all possible partial symbiotic messages and then to their anagram equivalents. Confounding and irrelevant influences were controlled; the results indicate that only the full symbiotic message improved motor performance. This strongly suggests that subjects encode the meaning of the full message and supports an interpretation in terms of an alleviation of an internal symbiotic conflict leading to a state of calmness conducive to improved motor performance.

  17. Spatiotemporal gait patterns during over ground locomotion in major depression compared with healthy controls.

    PubMed

    Lemke, M R; Wendorff, T; Mieth, B; Buhl, K; Linnemann, M

    2000-01-01

    Alterations of locomotion are frequent, observable features of patients suffering from depression and have been investigated in these patients by actigraphy, cinematography and ground reaction forces. However, spatiotemporal parameters and neurophysiological mechanisms of gait have not yet been studied in depth in depression. The relationship between spatial and temporal parameters may yield insight into the pathophysiology of altered movements in depression. Therefore, gait patterns were quantitatively assessed and analysed in depressed subjects (n=16) and compared to matched healthy controls. Spatiotemporal gait parameters were measured during over ground walking at self-selected walking speed on a walkway previously validated in healthy subjects and used for orthopaedic and neurological patients. Compared to controls, depressed patients showed significantly lower gait velocity (p<0.001), reduced stride length (p<0.005), double limb support (p<0.005) and cycle duration (p<0.005). There was a significant correlation between cadence and gait velocity in depressed patients (r=0.51, p<0.05), but not in healthy controls (r=0.11, p>0.05). In patients with major depression, reduced gait velocity was associated with stride hypometria and increased cycle duration. Velocity was associated with cadence in depressed patients but not in healthy controls. The results may indicate possible deficiencies in the motor control system in depression. These first results about alterations of spatiotemporal gait patterns in depression warrant further longitudinal and experimental studies.

  18. Polluted dust derived from long-range transport as a major end member of urban aerosols and its implication of non-point pollution in northern China.

    PubMed

    Yan, Y; Sun, Y B; Weiss, D; Liang, L J; Chen, H Y

    2015-02-15

    The contribution of polluted dust transported from local and distal sources remains poorly constrained due to their similar geophysical and geochemical properties. We sampled aerosols in three cities in northern China (Xi'an, Beijing, Xifeng) during the spring of 2009 to determine dust flux, magnetic susceptibility and elemental concentrations. Combining dust fluxes with wind speed and regional visibility records enabled to differentiate between dust transported from long range and derived from local sources, while the combination of magnetic susceptibility and enrichment factors (EF) of heavy metals (Pb, Zn) allowed to distinguish natural aerosols from polluted ones. Our results indicate that polluted dust from long-range transport became a major end member of urban dust aerosols. Human settlements as its potential sources were confirmed by a pollutant enriched regional dust event originating from populated areas to the south as inferred by back trajectory modeling, implying their non-point source nature of dust pollution.

  19. Two-axis Beam Steering Mirror Control system for Precision Pointing and Tracking Applications

    SciTech Connect

    Ulander, Klaus

    2006-01-01

    Precision pointing and tracking of laser beams is critical in numerous military and industrial applications. This is particularly true for systems requiring atmospheric beam propagation. Such systems are plagued by environmental influences which cause the optical signal to break up and wander. Example applications include laser communications, precision targeting, active imaging, chemical remote sensing, and laser vibrometry. The goal of this project is to build a beam steering system using a two-axis mirror to maintain precise pointing control. Ultimately, position control to 0.08% accuracy (40 {micro}rad) with a bandwidth of 200 Hz is desired. The work described encompasses evaluation of the instrumentation system and the subsequent design and implementation of an analog electronic controller for a two-axis mirror used to steer the beam. The controller operates over a wide temperature range, through multiple mirror resonances, and is independent of specific mirrors. The design was built and successfully fielded in a Lawrence Livermore National Laboratory free-space optics experiment. All measurements and performance parameters are derived from measurements made on actual hardware that was built and field tested. In some cases, specific design details have been omitted that involve proprietary information pertaining to Lawrence Livermore National Laboratory patent positions and claims. These omissions in no way impact the general validity of the work or concepts presented in this thesis.

  20. Interferometric adaptive optics testbed for laser pointing, wave-front control and phasing.

    PubMed

    Baker, K L; Homoelle, D; Utternback, E; Stappaerts, E A; Siders, C W; Barty, C P J

    2009-09-14

    Implementing the capability to perform fast ignition experiments, as well as, radiography experiments on the National Ignition Facility (NIF) places stringent requirements on the control of each of the beam's pointing, intra-beam phasing and overall wave-front quality. In this article experimental results are presented which were taken on an interferometric adaptive optics testbed that was designed and built to test the capabilities of such a system to control phasing, pointing and higher order beam aberrations. These measurements included quantification of the reduction in Strehl ratio incurred when using the MEMS device to correct for pointing errors in the system. The interferometric adaptive optics system achieved a Strehl ratio of 0.83 when correcting for a piston, tip/tilt error between two adjacent rectangular apertures, the geometry expected for the National ignition Facility. The interferometric adaptive optics system also achieved a Strehl ratio of 0.66 when used to correct for a phase plate aberration of similar magnitude as expected from simulations of the ARC beam line. All of these corrections included measuring both the upstream and downstream aberrations in the testbed and applying the sum of these two measurements in open-loop to the MEMS deformable mirror.

  1. Attitude Control of Planar End-Effector and Estimation of Contact Point Using Parallel Mechanism

    NASA Astrophysics Data System (ADS)

    Kubo, Ryogo; Ohnishi, Kouhei

    Recently, many robots have been utilized in unknown environment, for example, slave robots of teleoperation systems, walking robots and so on. They are called environment-adaptive robots. It is very important for the environment-adaptive robots to contact stably and to recognize unknown environment. In this paper, a compliance controller of attitude of a planar end-effector is proposed to achieve stable contact with unknown environment. The robot utilized in this research has parallel mechanism as a whole, since the planar end-effector is supported by three arms. With the assumption that only face-to-point contact exists between the end-effector and unknown environment, an estimation method of the contact point without sensors is also proposed. Moreover, excessive stress is not exerted on the robots and the environment by means of the controller we propose, when the contact point is estimated. Our new approach of contact motion can be widely applied to the robots using parallel mechanism. The validity of the proposed method is shown by the numerical and experimental results.

  2. On attitude estimation schemes for fine-pointing control. [of spacecraft

    NASA Technical Reports Server (NTRS)

    Joshi, S. M.

    1978-01-01

    This paper studies single-axis equations of motion that are applicable to a spacecraft or to a space experiment pointing assembly whose motion has been perfectly isolated from the carrier vehicle. It considers four state estimators for implementation in the control loop for a stellar observation experiment. The first three estimators are very general and do not make use of input torque in their prediction models, while the proposed fourth estimator utilizes this information. It is shown via closed-loop covariance analysis that the best achievable pointing performance with the best of the first three estimators is limited to about 0.125 arc-sec (rms) with the given rate-gyro and star-tracker inaccuracies. It is also shown that the fourth estimator has the capability of achieving a pointing performance far superior to the performance achievable using the first three estimators. The fourth estimator relies on the ability to accurately generate the desired control torque (i.e., low input noise).

  3. Comparison of point-of-care testing (POCT): i-STAT(®) international normalized ratio (INR) vs reference laboratory INR in pediatric patients undergoing major surgery.

    PubMed

    Spielmann, Nelly; Mauch, Jacqueline Y; Madjdpour, Caveh; Schmugge, Markus; Albisetti, Manuela; Weiss, Markus; Haas, Thorsten

    2011-10-01

    The aim of the study was to compare international normalized ratio (INR) results obtained by point-of-care testing (i-STAT® device) with the reference laboratory INR in children undergoing major surgery with expected significant blood loss.   Pediatric patients undergoing craniofacial, spine, hip, or cancer surgery were included. Blood samples for coagulation testing were tested at several intraoperative time points and generally withdrawn from the arterial catheter, if accessible. A volume of 1.4 ml citrated blood was used for the reference laboratory INR test, and 0.1 ml of blood was taken for the whole blood INR test using the i-STAT® device. Blood samples for both tests were withdrawn at the same time and immediately analyzed with both devices. A total of 169 paired blood samples were taken intraoperatively from 44 pediatric patients [IQR 0.9-10.7 years (median 3.3)]. Reference laboratory INR ranged from 0.96 to 3.43 (mean 1.40; sd 0.32) and INR of i-STAT® from 0.95 to 2.29 (mean 1.26; sd 0.22). The correlation coefficient was 0.83 (P < 0.001), and the bias values were 0.12 and 0.55 at the medical decision level of ≤2.0 and >2.0, respectively. In the perioperative setting, point-of-care INR testing in children using the i-STAT® device is a reliable and easy-to-handle method for INR values ≤2.0, while INR values >2.0 might be underestimated. © 2011 Blackwell Publishing Ltd.

  4. Bandwidth-limited robust nonlinear sliding control of pointing and tracking maneuvers

    NASA Technical Reports Server (NTRS)

    Dwyer, Thomas A. W., III; Kim, Jinho

    1989-01-01

    It is shown how multiaxial spacecraft tracking and pointing maneuvers with known control bandwidth and given tracking error bounds can be implemented by variable-structure control in the presence of uncertain vehicle and target dynamics. It is shown how to select a nonlinear sliding surface relating attitude and rate variables, as well as a Lyapunov function in the surface variables that absorbs multiplicative model undertainties, thereby simplifying the computation of control corrections. It is then shown how a boundary layer envelope can be designed, within which the components of the surface error dynamics can be modeled as the outputs of designer-selected decoupled low-pass filters. Closed-loop stability conditions accounting for the coupling between the attitude error dynamics and the surface error dynamics are then obtained.

  5. Formation Flying Satellite Control Around the L2 Sun-Earth Libration Point

    NASA Technical Reports Server (NTRS)

    Hamilton, Nicholas H.; Folta, David; Carpenter, Russell; Bauer, Frank (Technical Monitor)

    2002-01-01

    This paper discusses the development of a linear control algorithm for formations in the vicinity of the L2 sun-Earth libration point. The development of a simplified extended Kalman filter is included as well. Simulations are created for the analysis of the stationkeeping and various formation maneuvers of the Stellar Imager mission. The simulations provide tracking error, estimation error, and control effort results. For formation maneuvering, the formation spacecraft track to within 4 meters of their desired position and within 1.5 millimeters per second of their desired zero velocity. The filter, with few exceptions, keeps the estimation errors within their three-sigma values. Without noise, the controller performs extremely well, with the formation spacecraft tracking to within several micrometers. Each spacecraft uses around 1 to 2 grams of propellant per maneuver, depending on the circumstances.

  6. Treating major depression with yoga: A prospective, randomized, controlled pilot trial.

    PubMed

    Prathikanti, Sudha; Rivera, Renee; Cochran, Ashly; Tungol, Jose Gabriel; Fayazmanesh, Nima; Weinmann, Eva

    2017-01-01

    Conventional pharmacotherapies and psychotherapies for major depression are associated with limited adherence to care and relatively low remission rates. Yoga may offer an alternative treatment option, but rigorous studies are few. This randomized controlled trial with blinded outcome assessors examined an 8-week hatha yoga intervention as mono-therapy for mild-to-moderate major depression. Investigators recruited 38 adults in San Francisco meeting criteria for major depression of mild-to-moderate severity, per structured psychiatric interview and scores of 14-28 on Beck Depression Inventory-II (BDI). At screening, individuals engaged in psychotherapy, antidepressant pharmacotherapy, herbal or nutraceutical mood therapies, or mind-body practices were excluded. Participants were 68% female, with mean age 43.4 years (SD = 14.8, range = 22-72), and mean BDI score 22.4 (SD = 4.5). Twenty participants were randomized to 90-minute hatha yoga practice groups twice weekly for 8 weeks. Eighteen participants were randomized to 90-minute attention control education groups twice weekly for 8 weeks. Certified yoga instructors delivered both interventions at a university clinic. Primary outcome was depression severity, measured by BDI scores every 2 weeks from baseline to 8 weeks. Secondary outcomes were self-efficacy and self-esteem, measured by scores on the General Self-Efficacy Scale (GSES) and Rosenberg Self-Esteem Scale (RSES) at baseline and at 8 weeks. In intent-to-treat analysis, yoga participants exhibited significantly greater 8-week decline in BDI scores than controls (p-value = 0.034). In sub-analyses of participants completing final 8-week measures, yoga participants were more likely to achieve remission, defined per final BDI score ≤ 9 (p-value = 0.018). Effect size of yoga in reducing BDI scores was large, per Cohen's d = -0.96 [95%CI, -1.81 to -0.12]. Intervention groups did not differ significantly in 8-week change scores for either the GSES or RSES. In

  7. Treating major depression with yoga: A prospective, randomized, controlled pilot trial

    PubMed Central

    Rivera, Renee; Cochran, Ashly; Tungol, Jose Gabriel; Fayazmanesh, Nima; Weinmann, Eva

    2017-01-01

    Background Conventional pharmacotherapies and psychotherapies for major depression are associated with limited adherence to care and relatively low remission rates. Yoga may offer an alternative treatment option, but rigorous studies are few. This randomized controlled trial with blinded outcome assessors examined an 8-week hatha yoga intervention as mono-therapy for mild-to-moderate major depression. Methods Investigators recruited 38 adults in San Francisco meeting criteria for major depression of mild-to-moderate severity, per structured psychiatric interview and scores of 14–28 on Beck Depression Inventory-II (BDI). At screening, individuals engaged in psychotherapy, antidepressant pharmacotherapy, herbal or nutraceutical mood therapies, or mind-body practices were excluded. Participants were 68% female, with mean age 43.4 years (SD = 14.8, range = 22–72), and mean BDI score 22.4 (SD = 4.5). Twenty participants were randomized to 90-minute hatha yoga practice groups twice weekly for 8 weeks. Eighteen participants were randomized to 90-minute attention control education groups twice weekly for 8 weeks. Certified yoga instructors delivered both interventions at a university clinic. Primary outcome was depression severity, measured by BDI scores every 2 weeks from baseline to 8 weeks. Secondary outcomes were self-efficacy and self-esteem, measured by scores on the General Self-Efficacy Scale (GSES) and Rosenberg Self-Esteem Scale (RSES) at baseline and at 8 weeks. Results In intent-to-treat analysis, yoga participants exhibited significantly greater 8-week decline in BDI scores than controls (p-value = 0.034). In sub-analyses of participants completing final 8-week measures, yoga participants were more likely to achieve remission, defined per final BDI score ≤ 9 (p-value = 0.018). Effect size of yoga in reducing BDI scores was large, per Cohen’s d = -0.96 [95%CI, -1.81 to -0.12]. Intervention groups did not differ significantly in 8-week change scores for

  8. Ground-based telescope pointing and tracking optimization using a neural controller.

    PubMed

    Mancini, D; Brescia, M; Schipani, P

    2003-01-01

    Neural network models (NN) have emerged as important components for applications of adaptive control theories. Their basic generalization capability, based on acquired knowledge, together with execution rapidity and correlation ability between input stimula, are basic attributes to consider NN as an extremely powerful tool for on-line control of complex systems. By a control system point of view, not only accuracy and speed, but also, in some cases, a high level of adaptation capability is required in order to match all working phases of the whole system during its lifetime. This is particularly remarkable for a new generation ground-based telescope control system. Infact, strong changes in terms of system speed and instantaneous position error tolerance are necessary, especially in case of trajectory disturb induced by wind shake. The classical control scheme adopted in such a system is based on the proportional integral (PI) filter, already applied and implemented on a large amount of new generation telescopes, considered as a standard in this technological environment. In this paper we introduce the concept of a new approach, the neural variable structure proportional integral, (NVSPI), related to the implementation of a standard multi layer perceptron network in new generation ground-based Alt-Az telescope control systems. Its main purpose is to improve adaptive capability of the Variable structure proportional integral model, an already innovative control scheme recently introduced by authors [Proc SPIE (1997)], based on a modified version of classical PI control model, in terms of flexibility and accuracy of the dynamic response range also in presence of wind noise effects. The realization of a powerful well tested and validated telescope model simulation system allowed the possibility to directly compare performances of the two control schemes on simulated tracking trajectories, revealing extremely encouraging results in terms of NVSPI control robustness and

  9. The dynamics and control of large flexible space structures, 2. Part A: Shape and orientation control using point actuators

    NASA Technical Reports Server (NTRS)

    Bainum, P. M.; Reddy, A. S. S. R.

    1979-01-01

    The equations of planar motion for a flexible beam in orbit which includes the effects of gravity gradient torques and control torques from point actuators located along the beam was developed. Two classes of theorems are applied to the linearized form of these equations to establish necessary conditions for controlability for preselected actuator configurations. The feedback gains are selected: (1) based on the decoupling of the original coordinates and to obtain proper damping, and (2) by applying the linear regulator problem to the individual model coordinates separately. The linear control laws obtained using both techniques were evaluated by numerical integration of the nonlinear system equations. Numerical examples considering pitch and various number of modes with different combination of actuator numbers and locations are presented. The independent model control concept used earlier with a discretized model of the thin beam in orbit was reviewed for the case where the number of actuators is less than the number of modes. Results indicate that although the system is controllable it is not stable about the nominal (local vertical) orientation when the control is based on modal decoupling. An alternate control law not based on modal decoupling ensures stability of all the modes.

  10. Pathogen Reduction and Hazard Analysis and Critical Control Point (HACCP) systems for meat and poultry. USDA.

    PubMed

    Hogue, A T; White, P L; Heminover, J A

    1998-03-01

    The United States Department of Agriculture (USDA) Food Safety Inspection Service (FSIS) adopted Hazard Analysis and Critical Control Point Systems and established finished product standards for Salmonella in slaughter plants to improve food safety for meat and poultry. In order to make significant improvements in food safety, measures must be taken at all points in the farm-to-table chain including production, transportation, slaughter, processing, storage, retail, and food preparation. Since pathogens can be introduced or multiplied anywhere along the continuum, success depends on consideration and comparison of intervention measures throughout the continuum. Food animal and public health veterinarians can create the necessary preventative environment that mitigates risks for food borne pathogen contamination.

  11. Point source modeling of matched case–control data with multiple disease subtypes

    PubMed Central

    Li, Shi; Mukherjee, Bhramar; Batterman, Stuart

    2015-01-01

    In this paper, we propose nonlinear distance-odds models investigating elevated odds around point sources of exposure, under a matched case-control design where there are subtypes within cases. We consider models analogous to the polychotomous logit models and adjacent-category logit models for categorical outcomes and extend them to the nonlinear distance-odds context. We consider multiple point sources as well as covariate adjustments. We evaluate maximum likelihood, profile likelihood, iteratively reweighted least squares, and a hierarchical Bayesian approach using Markov chain Monte Carlo techniques under these distance-odds models. We compare these methods using an extensive simulation study and show that with multiple parameters and a nonlinear model, Bayesian methods have advantages in terms of estimation stability, precision, and interpretation. We illustrate the methods by analyzing Medicaid claims data corresponding to the pediatric asthma population in Detroit, Michigan, from 2004 to 2006. PMID:22826092

  12. Point source modeling of matched case-control data with multiple disease subtypes.

    PubMed

    Li, Shi; Mukherjee, Bhramar; Batterman, Stuart

    2012-12-10

    In this paper, we propose nonlinear distance-odds models investigating elevated odds around point sources of exposure, under a matched case-control design where there are subtypes within cases. We consider models analogous to the polychotomous logit models and adjacent-category logit models for categorical outcomes and extend them to the nonlinear distance-odds context. We consider multiple point sources as well as covariate adjustments. We evaluate maximum likelihood, profile likelihood, iteratively reweighted least squares, and a hierarchical Bayesian approach using Markov chain Monte Carlo techniques under these distance-odds models. We compare these methods using an extensive simulation study and show that with multiple parameters and a nonlinear model, Bayesian methods have advantages in terms of estimation stability, precision, and interpretation. We illustrate the methods by analyzing Medicaid claims data corresponding to the pediatric asthma population in Detroit, Michigan, from 2004 to 2006.

  13. Comparison of Clinical Features and Personality Dimensions between Patients with Major Depressive Disorder and Normal Control.

    PubMed

    Hur, Ji-Won; Kim, Yong-Ku

    2009-09-01

    Personality dimension is considered as a risk factor of depression. This study was to compare aggression, impulsivity, hopelessness, and TCI (temperament and character dimensions) between patients with major depressive disorder (MDD) and normal controls. A total of 56 MDD patients and the same number of normal controls who were matched for age, gender, and education were recruited. All subjects completed the following questionnaires; Aggression Questionnaire (AQ), Beck Hopelessness Scale (BHS), Barratt Impulsiveness Scale, 11th Version (BIS-11), and Temperament and Character Inventory (TCI). MDD patients were significantly higher scores in anger, hostility of AQ, BHS, motor impulsivity of BIS-11, and Harm Avoidances (HA) of TCI with all subscales of HA than normal controls, whereas novelty seeking 1 (NS1) (Exploratory of NS), Reward Dependence (RD) with RD3 (Attachment) . RD4 (Dependence), Self-Directedness (SD) with most subscales of SD, Cooperativeness (CO), and ST3 (Spiritual Acceptance) showed lower scores than normal controls. Moreover, BHS and HA, BIS and NS showed moderate positive correlation in MDD patients, while BHS and SD, HA and SD were negatively correlated. The present study showed unique clinical features, especially personality dimensions of patients with MDD. Our results could be applicable to suggest treatment process and to predict one's prognosis for depression in that psychological properties are important for drug compliance and treatment response.

  14. Comparison of Clinical Features and Personality Dimensions between Patients with Major Depressive Disorder and Normal Control

    PubMed Central

    Hur, Ji-Won

    2009-01-01

    Objective Personality dimension is considered as a risk factor of depression. This study was to compare aggression, impulsivity, hopelessness, and TCI (temperament and character dimensions) between patients with major depressive disorder (MDD) and normal controls. Methods A total of 56 MDD patients and the same number of normal controls who were matched for age, gender, and education were recruited. All subjects completed the following questionnaires; Aggression Questionnaire (AQ), Beck Hopelessness Scale (BHS), Barratt Impulsiveness Scale, 11th Version (BIS-11), and Temperament and Character Inventory (TCI). Results MDD patients were significantly higher scores in anger, hostility of AQ, BHS, motor impulsivity of BIS-11, and Harm Avoidances (HA) of TCI with all subscales of HA than normal controls, whereas novelty seeking 1 (NS1) (Exploratory of NS), Reward Dependence (RD) with RD3 (Attachment) · RD4 (Dependence), Self-Directedness (SD) with most subscales of SD, Cooperativeness (CO), and ST3 (Spiritual Acceptance) showed lower scores than normal controls. Moreover, BHS and HA, BIS and NS showed moderate positive correlation in MDD patients, while BHS and SD, HA and SD were negatively correlated. Conclusion The present study showed unique clinical features, especially personality dimensions of patients with MDD. Our results could be applicable to suggest treatment process and to predict one's prognosis for depression in that psychological properties are important for drug compliance and treatment response. PMID:20046389

  15. Effectiveness of Aerobic Exercise as an Augmentation Therapy for Inpatients with Major Depressive Disorder: A Preliminary Randomized Controlled Trial.

    PubMed

    Shachar-Malach, Tal; Cooper Kazaz, Rena; Constantini, Naama; Lifschytz, Tzuri; Lerer, Bernard

    2015-01-01

    Physical exercise has been shown to reduce depressive symptoms when used in combination with antidepressant medication. We report a randomized controlled trial of aerobic exercise compared to stretching as an augmentation strategy for hospitalized patients with major depression. Male or female patients, 18-80 years, diagnosed with a Major Depressive Episode, were randomly assigned to three weeks of augmentation therapy with aerobic (n=6) or stretching exercise (n=6). Depression was rated, at several time points using the 21-item Hamilton Depression Scale (HAM-D), Beck Depression Inventory (BDI) and other scales. According to the HAM-D, there were four (out of six) responders in the aerobic group, two of whom achieved remission, and none in the stretching group. According to the BDI, there were two responders in the aerobic group who were also remitters and none in the stretching group. The results of this small study suggest that aerobic exercise significantly improves treatment outcome when added to antidepressant medication. However, due to the small sample size the results must be regarded as preliminary and further studies are needed to confirm the findings.

  16. Post-operative endophthalmitis: the application of hazard analysis critical control points (HACCP) to an infection control problem.

    PubMed

    Baird, D R; Henry, M; Liddell, K G; Mitchell, C M; Sneddon, J G

    2001-09-01

    Hazard analysis critical control points (HACCP) is a quality assurance system widely used in the food industry to ensure safety. We adopted the HACCP approach when conventional infection control measures had failed to solve an ongoing problem with an increased incidence of postoperative endophthalmitis, and our ophthalmology unit was threatened with permanent cessation of intraocular surgery. Although time-consuming, the result was an entirely new set of protocols for the care of patients undergoing intraocular surgery, the development of an integrated care pathway, and a comprehensive and robust audit programme, which enabled intraocular surgery to continue in a new spirit of confidence. HACCP methodology has so far been little used in healthcare, but it might be usefully applied to a variety of apparently intractable infection control problems. Copyright 2001 The Hospital Infection Society.

  17. Effectiveness of trigger point dry needling for plantar heel pain: a randomized controlled trial.

    PubMed

    Cotchett, Matthew P; Munteanu, Shannon E; Landorf, Karl B

    2014-08-01

    Plantar heel pain can be managed with dry needling of myofascial trigger points; however, there is only poor-quality evidence supporting its use. The purpose of this study was to evaluate the effectiveness of dry needling for plantar heel pain. The study was a parallel-group, participant-blinded, randomized controlled trial. The study was conducted in a university health sciences clinic. Study participants were 84 patients with plantar heel pain of at least 1 month's duration. Participants were randomly assigned to receive real or sham trigger point dry needling. The intervention consisted of 1 treatment per week for 6 weeks. Participants were followed for 12 weeks. Primary outcome measures included first-step pain, as measured with a visual analog scale (VAS), and foot pain, as measured with the pain subscale of the Foot Health Status Questionnaire (FHSQ). The primary end point for predicting the effectiveness of dry needling for plantar heel pain was 6 weeks. At the primary end point, significant effects favored real dry needling over sham dry needling for pain (adjusted mean difference: VAS first-step pain=-14.4 mm, 95% confidence interval [95% CI]=-23.5 to -5.2; FHSQ foot pain=10.0 points, 95% CI=1.0 to 19.1), although the between-group difference was lower than the minimal important difference. The number needed to treat at 6 weeks was 4 (95% CI=2 to 12). The frequency of minor transitory adverse events was significantly greater in the real dry needling group (70 real dry needling appointments [32%] compared with only 1 sham dry needling appointment [<1%]). It was not possible to blind the therapist. Dry needling provided statistically significant reductions in plantar heel pain, but the magnitude of this effect should be considered against the frequency of minor transitory adverse events. © 2014 American Physical Therapy Association.

  18. Rectification control points selection method of triangle mesh in optical pressure measurement of wind-tunnel test.

    PubMed

    Chen, Yong; Chen, Chang

    2014-08-01

    In optical pressure measurement of wind-tunnel test, triangle mesh is usually built to rectify the images that are distorted in geometry. In this paper, a novel method of control points selection of triangle mesh is proposed by combining the artificial points and margin control points. For the problem that in the condition of wind the margin control point is difficult to extract due to model distortion and grey variation, an improved Smallest Univalue Segment Assimilating Nucleus algorithm based on region selection and adaptive threshold is designed. The connection method is employed to verify the availability of points, which avoids that the noisy points are mistakenly regarded as the angular points. The distorted images of aircraft model are rectified and the results are analyzed. Experiments demonstrate that the proposed method greatly improves the rectification effect.

  19. The organization of roots of dicotyledonous plants and the positions of control points.

    PubMed

    Rost, Thomas L

    2011-05-01

    The structure of roots has been studied for many years, but despite their importance to the growth and well-being of plants, most researchers tend to ignore them. This is unfortunate, because their simple body plan makes it possible to study complex developmental pathways without the complications sometimes found in the shoot. In this illustrated essay, my objective is to describe the body plan of the root and the root apical meristem (RAM) and point out the control points where differentiation and cell cycle decisions are made. Hopefully this outline will assist plant biologists in identifying the structural context for their observations. This short paper outlines the types of RAM, i.e. basic-open, intermediate-open and closed, shows how they are similar and different, and makes the point that the structure and shape of the RAM are not static, but changes in shape, size and organization occur depending on root growth rate and development stage. RAMs with a closed organization lose their outer root cap layers in sheets of dead cells, while those with an open organization release living border cells from the outer surfaces of the root cap. This observation suggests a possible difference in the mechanisms whereby roots with different RAM types communicate with soil-borne micro-organisms. The root body is organized in cylinders, sectors (xylem and phloem in the vascular cylinder), cell files, packets and modules, and individual cells. The differentiation in these root development units is regulated at control points where genetic regulation is needed, and the location of these tissue-specific control points can be modulated as a function of root growth rate. In Arabidopsis thaliana the epidermis and peripheral root cap develop through a highly regulated series of steps starting with a periclinal division of an initial cell, the root cap/protoderm (RCP) initial. The derivative cells from the RCP initial divide into two cells, the inner cell divides again to renew the

  20. Synergies in the space of control variables within the equilibrium-point hypothesis.

    PubMed

    Ambike, S; Mattos, D; Zatsiorsky, V M; Latash, M L

    2016-02-19

    We use an approach rooted in the recent theory of synergies to analyze possible co-variation between two hypothetical control variables involved in finger force production based on the equilibrium-point (EP) hypothesis. These control variables are the referent coordinate (R) and apparent stiffness (C) of the finger. We tested a hypothesis that inter-trial co-variation in the {R; C} space during repeated, accurate force production trials stabilizes the fingertip force. This was expected to correspond to a relatively low amount of inter-trial variability affecting force and a high amount of variability keeping the force unchanged. We used the "inverse piano" apparatus to apply small and smooth positional perturbations to fingers during force production tasks. Across trials, R and C showed strong co-variation with the data points lying close to a hyperbolic curve. Hyperbolic regressions accounted for over 99% of the variance in the {R; C} space. Another analysis was conducted by randomizing the original {R; C} data sets and creating surrogate data sets that were then used to compute predicted force values. The surrogate sets always showed much higher force variance compared to the actual data, thus reinforcing the conclusion that finger force control was organized in the {R; C} space, as predicted by the EP hypothesis, and involved co-variation in that space stabilizing total force. Copyright © 2015 IBRO. Published by Elsevier Ltd. All rights reserved.

  1. [The different point of view about the sanitary control of importation of psychotropic substances in Brazil].

    PubMed

    Sebastião, Patrícia Cristina Antunes; Lucchese, Geraldo

    2010-11-01

    The purpose of this work is to analyze the process of importation, that is a part of the sanitary control of psychotropic substances, made by Brazilian National Health Surveillance Agency's ports, airports and borders. For this work, psychotropic substances are defined as active pharmaceutical raw materials present in the list B1 of Portaria nº 344/98; which need Anvisa's permission to be imported. For this purpose we used semistructured interviews with key informers and participant observation. The information were collected and systematized through the content analysis, thematic modality. The results show a very complex control which involves an intense bureaucratic process. The main identified critical points of the process were: the information system precariousness; the absence of human resources; deficiency of laboratorial support and infra-structure at customs. Anvisa's web page and the specific law are strong points of the process, but still needing improvements. We understood that despite of the progress made, there are many things to do for giving the country an efficient health control system to the importation of these substances.

  2. The Hazard Analysis and Critical Control Points (HACCP) generic model for the production of Thai fermented pork sausage (Nham).

    PubMed

    Paukatong, K V; Kunawasen, S

    2001-01-01

    Nham is a traditional Thai fermented pork sausage. The major ingredients of Nham are ground pork meat and shredded pork rind. Nham has been reported to be contaminated with Salmonella spp., Staphylococcus aureus, and Listeria monocytogenes. Therefore, it is a potential cause of foodborne diseases for consumers. A Hazard Analysis and Critical Control Points (HACCP) generic model has been developed for the Nham process. Nham processing plants were observed and a generic flow diagram of Nham processes was constructed. Hazard analysis was then conducted. Other than microbial hazards, the pathogens previously found in Nham, sodium nitrite and metal were identified as chemical and physical hazards in this product, respectively. Four steps in the Nham process have been identified as critical control points. These steps are the weighing of the nitrite compound, stuffing, fermentation, and labeling. The chemical hazard of nitrite must be controlled during the weighing step. The critical limit of nitrite levels in the Nham mixture has been set at 100-200 ppm. This level is high enough to control Clostridium botulinum but does not cause chemical hazards to the consumer. The physical hazard from metal clips could be prevented by visual inspection of every Nham product during stuffing. The microbiological hazard in Nham could be reduced in the fermentation process. The critical limit of the pH of Nham was set at lower than 4.6. Since this product is not cooked during processing, finally, educating the consumer, by providing information on the label such as "safe if cooked before consumption", could be an alternative way to prevent the microbiological hazards of this product.

  3. Datum maintenance of the main Egyptian geodetic control networks by utilizing Precise Point Positioning "PPP" technique

    NASA Astrophysics Data System (ADS)

    Rabah, Mostafa; Elmewafey, Mahmoud; Farahan, Magda H.

    2016-06-01

    A geodetic control network is the wire-frame or the skeleton on which continuous and consistent mapping, Geographic Information Systems (GIS), and surveys are based. Traditionally, geodetic control points are established as permanent physical monuments placed in the ground and precisely marked, located, and documented. With the development of satellite surveying methods and their availability and high degree of accuracy, a geodetic control network could be established by using GNSS and referred to an international terrestrial reference frame used as a three-dimensional geocentric reference system for a country. Based on this concept, in 1992, the Egypt Survey Authority (ESA) established two networks, namely High Accuracy Reference Network (HARN) and the National Agricultural Cadastral Network (NACN). To transfer the International Terrestrial Reference Frame to the HARN, the HARN was connected with four IGS stations. The processing results were 1:10,000,000 (Order A) for HARN and 1:1,000,000 (Order B) for NACN relative network accuracy standard between stations defined in ITRF1994 Epoch1996. Since 1996, ESA did not perform any updating or maintaining works for these networks. To see how non-performing maintenance degrading the values of the HARN and NACN, the available HARN and NACN stations in the Nile Delta were observed. The Processing of the tested part was done by CSRS-PPP Service based on utilizing Precise Point Positioning "PPP" and Trimble Business Center "TBC". The study shows the feasibility of Precise Point Positioning in updating the absolute positioning of the HARN network and its role in updating the reference frame (ITRF). The study also confirmed the necessity of the absent role of datum maintenance of Egypt networks.

  4. Uncertainty Analysis of non-point source pollution control facilities design techniques in Korea

    NASA Astrophysics Data System (ADS)

    Lee, J.; Okjeong, L.; Gyeong, C. B.; Park, M. W.; Kim, S.

    2015-12-01

    The design of non-point sources control facilities in Korea is divided largely by the stormwater capture ratio, the stormwater load capture ratio, and the pollutant reduction efficiency of the facility. The stormwater capture ratio is given by a design formula as a function of the water quality treatment capacity, the greater the capacity, the more the amount of stormwater intercepted by the facility. The stormwater load capture ratio is defined as the ratio of the load entering the facility of the total pollutant load generated in the target catchment, and is given as a design formula represented by a function of the stormwater capture ratio. In order to estimate the stormwater capture ratio and load capture ratio, a lot of quantitative analysis of hydrologic processes acted in pollutant emission is required, but these formulas have been applied without any verification. Since systematic monitoring programs were insufficient, verification of these formulas was fundamentally impossible. However, recently the Korean ministry of Environment has conducted an long-term systematic monitoring project, and thus the verification of the formulas became possible. In this presentation, the stormwater capture ratio and load capture ratio are re-estimated using actual TP data obtained from long-term monitoring program at Noksan industrial complex located in Busan, Korea. Through the re-estimated process, the uncertainty included in the design process that has been applied until now will be shown in a quantitative extent. In addition, each uncertainty included in the stormwater capture ratio estimation and in the stormwater load capture ratio estimation will be expressed to quantify the relative impact on the overall non-point pollutant control facilities design process. Finally, the SWMM-Matlab interlocking module for model parameters estimation will be introduced. Acknowledgement This subject is supported by Korea Ministry of Environment as "The Eco Innovation Project : Non-point

  5. The hazard analysis and critical control point system in food safety.

    PubMed

    Herrera, Anavella Gaitan

    2004-01-01

    The Hazard Analysis and Critical Control Point (HACCP) system is a preventive method of ensuring food safety. Its objectives are the identification of consumer safety hazards that can occur in the production line and the establishment of a control process to guarantee a safer product for the consumer; it is based on the identification of potential hazards to food safety and on measures aimed at preventing these hazards. HACCP is the system of choice in the management of food safety. The principles of HACCP are applicable to all phases of food production, including basic husbandry practices, food preparation and handling, food processing, food service, distribution systems, and consumer handling and use. The HACCP system is involved in every aspect of food safety production (according to the UN Food and Agriculture Organization [FAO] and the International Commission on Microbiological Specifications for Foods [ICMSF]). The most basic concept underlying the HACCP system is that of prevention rather than inspection. The control of processes and conditions comprises the critical control point (CCP) element. HACCP is simply a methodical, flexible, and systematic application of the appropriate science and technology for planning, controlling, and documenting the safe production of foods. The successful application of HACCP requires the full commitment and involvement of management and the workforce, using a multidisciplinary approach that should include, as appropriate, expertise in agronomy, veterinary health, microbiology, public health, food technology, environmental health, chemistry, engineering, and so on according to the particular situation. Application of the HACCP system is compatible with the implementation of total quality management (TQM) systems such as the ISO 9000 series.

  6. Stability and control problems in Earth-Moon Lagrangian point L2

    NASA Astrophysics Data System (ADS)

    Palutan, F.

    1994-11-01

    The use of periodic trajectories around L2 Lagrangian point for lunar operations has been proposed by many authors. A single telecommunication relay, place around L2, could guarantee the permanent connection between the Earth and a lunar base on the far side of the moon, with a 440,000 km link from the Earth and a 64,000 km link from the lunar surface. However, the control of a satellite in L2 Lagrangian point is quite difficult, due to the intrinsic dynamic unstability. To do it, it is necessary to observe continuously the orbital state of the satellite, and control the dynamics of the vehicle with a suitable on-board propulsion system. The analysis of these problems was performed by Farquhar, starting from 1970, and others (Sim, et al 1987). The same concepts were developed, by the author, in a study for European Space Agency (ESA) on a space communication network, for lunar and deep space missions. The present communication describes the dynamics in L2 and in the periodic orbits around L2 (halo orbits). It discusses the possibility of the orbit control, with a particular reference to the control laws based on the observation of the position and velocity of the spacecraft in the Earth-Moon direction. Some numerical simulations are presented, performed with a numerical propagator, to verify the dynamics of the satellite in presence of the perturbations, not accounted for in a simplified analytical approach. The possibility of controlling the satellite with a station-keeping procedure, similar to that used for geostationary satellites, is verified.

  7. Robust Brain-Machine Interface Design Using Optimal Feedback Control Modeling and Adaptive Point Process Filtering

    PubMed Central

    Carmena, Jose M.

    2016-01-01

    Much progress has been made in brain-machine interfaces (BMI) using decoders such as Kalman filters and finding their parameters with closed-loop decoder adaptation (CLDA). However, current decoders do not model the spikes directly, and hence may limit the processing time-scale of BMI control and adaptation. Moreover, while specialized CLDA techniques for intention estimation and assisted training exist, a unified and systematic CLDA framework that generalizes across different setups is lacking. Here we develop a novel closed-loop BMI training architecture that allows for processing, control, and adaptation using spike events, enables robust control and extends to various tasks. Moreover, we develop a unified control-theoretic CLDA framework within which intention estimation, assisted training, and adaptation are performed. The architecture incorporates an infinite-horizon optimal feedback-control (OFC) model of the brain’s behavior in closed-loop BMI control, and a point process model of spikes. The OFC model infers the user’s motor intention during CLDA—a process termed intention estimation. OFC is also used to design an autonomous and dynamic assisted training technique. The point process model allows for neural processing, control and decoder adaptation with every spike event and at a faster time-scale than current decoders; it also enables dynamic spike-event-based parameter adaptation unlike current CLDA methods that use batch-based adaptation on much slower adaptation time-scales. We conducted closed-loop experiments in a non-human primate over tens of days to dissociate the effects of these novel CLDA components. The OFC intention estimation improved BMI performance compared with current intention estimation techniques. OFC assisted training allowed the subject to consistently achieve proficient control. Spike-event-based adaptation resulted in faster and more consistent performance convergence compared with batch-based methods, and was robust to

  8. Robust Brain-Machine Interface Design Using Optimal Feedback Control Modeling and Adaptive Point Process Filtering.

    PubMed

    Shanechi, Maryam M; Orsborn, Amy L; Carmena, Jose M

    2016-04-01

    Much progress has been made in brain-machine interfaces (BMI) using decoders such as Kalman filters and finding their parameters with closed-loop decoder adaptation (CLDA). However, current decoders do not model the spikes directly, and hence may limit the processing time-scale of BMI control and adaptation. Moreover, while specialized CLDA techniques for intention estimation and assisted training exist, a unified and systematic CLDA framework that generalizes across different setups is lacking. Here we develop a novel closed-loop BMI training architecture that allows for processing, control, and adaptation using spike events, enables robust control and extends to various tasks. Moreover, we develop a unified control-theoretic CLDA framework within which intention estimation, assisted training, and adaptation are performed. The architecture incorporates an infinite-horizon optimal feedback-control (OFC) model of the brain's behavior in closed-loop BMI control, and a point process model of spikes. The OFC model infers the user's motor intention during CLDA-a process termed intention estimation. OFC is also used to design an autonomous and dynamic assisted training technique. The point process model allows for neural processing, control and decoder adaptation with every spike event and at a faster time-scale than current decoders; it also enables dynamic spike-event-based parameter adaptation unlike current CLDA methods that use batch-based adaptation on much slower adaptation time-scales. We conducted closed-loop experiments in a non-human primate over tens of days to dissociate the effects of these novel CLDA components. The OFC intention estimation improved BMI performance compared with current intention estimation techniques. OFC assisted training allowed the subject to consistently achieve proficient control. Spike-event-based adaptation resulted in faster and more consistent performance convergence compared with batch-based methods, and was robust to parameter

  9. Floating-point scaling technique for sources separation automatic gain control

    NASA Astrophysics Data System (ADS)

    Fermas, A.; Belouchrani, A.; Ait-Mohamed, O.

    2012-07-01

    Based on the floating-point representation and taking advantage of scaling factor indetermination in blind source separation (BSS) processing, we propose a scaling technique applied to the separation matrix, to avoid the saturation or the weakness in the recovered source signals. This technique performs an automatic gain control in an on-line BSS environment. We demonstrate the effectiveness of this technique by using the implementation of a division-free BSS algorithm with two inputs, two outputs. The proposed technique is computationally cheaper and efficient for a hardware implementation compared to the Euclidean normalisation.

  10. Knowledge-based monitoring of the pointing control system on the Hubble space telescope

    NASA Technical Reports Server (NTRS)

    Dunham, Larry L.; Laffey, Thomas J.; Kao, Simon M.; Schmidt, James L.; Read, Jackson Y.

    1987-01-01

    A knowledge-based system for the real time monitoring of telemetry data from the Pointing and Control System (PCS) of the Hubble Space Telescope (HST) that enables the retention of design expertise throughout the three decade project lifespan by means other than personnel and documentation is described. The system will monitor performance, vehicle status, success or failure of various maneuvers, and in some cases diagnose problems and recommend corrective actions using a knowledge base built using mission scenarios and the more than 4,500 telemetry monitors from the HST.

  11. White matter correlates of impaired attention control in major depressive disorder and healthy volunteers.

    PubMed

    Rizk, Mina M; Rubin-Falcone, Harry; Keilp, John; Miller, Jeffrey M; Sublette, M Elizabeth; Burke, Ainsley; Oquendo, Maria A; Kamal, Ahmed M; Abdelhameed, Mohamed A; Mann, J John

    2017-11-01

    Major depressive disorder (MDD) is associated with impaired attention control and alterations in frontal-subcortical connectivity. We hypothesized that attention control as assessed by Stroop task interference depends on white matter integrity in fronto-cingulate regions and assessed this relationship using diffusion tensor imaging (DTI) in MDD and healthy volunteers (HV). DTI images and Stroop task were acquired in 29 unmedicated MDD patients and 16 HVs, aged 18-65 years. The relationship between Stroop interference and fractional anisotropy (FA) was examined using region-of-interest (ROI) and tract-based spatial statistics (TBSS) analyses. ROI analysis revealed that Stroop interference correlated positively with FA in left caudal anterior cingulate cortex (cACC) in HVs (r = 0.62, p = 0.01), but not in MDD (r = -0.05, p= 0.79) even after controlling for depression severity. The left cACC was among 4 ROIs in fronto-cingulate network where FA was lower in MDD relative to HVs (F(1,41) = 8.87, p = 0.005). Additionally, TBSS showed the same group interaction of differences and correlations, although only at a statistical trend level. The modest sample size limits the generalizability of the findings. Structural connectivity of white matter network of cACC correlated with magnitude of Stroop interference in HVs, but not MDD. The cACC-frontal network, sub-serving attention control, may be disrupted in MDD. Less cognitive control may include enhanced effects of salience in HVs, or less effective response inhibition in MDD. Further studies of salience and inhibition components of executive function may better elucidate the relationship between brain white matter changes and executive dysfunction in MDD. Copyright © 2017 Elsevier B.V. All rights reserved.

  12. 41 CFR 101-26.606 - Supply support available from the inventory control points of the military departments.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... from the inventory control points of the military departments. 101-26.606 Section 101-26.606 Public... § 101-26.606 Supply support available from the inventory control points of the military departments. Federal civil agencies may obtain items of supply which are procured and managed by the inventory...

  13. 41 CFR 101-26.606 - Supply support available from the inventory control points of the military departments.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... from the inventory control points of the military departments. 101-26.606 Section 101-26.606 Public... § 101-26.606 Supply support available from the inventory control points of the military departments. Federal civil agencies may obtain items of supply which are procured and managed by the inventory...

  14. Effects of acute cortisol administration on response inhibition in patients with major depression and healthy controls.

    PubMed

    Schlosser, Nicole; Wolf, Oliver Tobias; Fernando, Silvia Carvalho; Terfehr, Kirsten; Otte, Christian; Spitzer, Carsten; Beblo, Thomas; Driessen, Martin; Löwe, Bernd; Wingenfeld, Katja

    2013-10-30

    Glucocorticoids (GCs) have repeatedly been shown to impair hippocampus-mediated, declarative memory retrieval and prefrontal cortex-based working memory in healthy subjects. However, recent experimental studies indicated that patients with major depressive disorder (MDD) lack these impairing effects. These missing effects have been suggested to result from dysfunctional brain GC receptors. The purpose of the present study was to investigate whether response inhibition, an executive function relying on the integrity of the prefrontal cortex, would be impaired after cortisol administration in patients with MDD. In a placebo-controlled, double blind crossover study, 50 inpatients with MDD and 54 healthy control participants conducted an emotional go/no-go task consisting of human face stimuli (fearful, happy, and neutral) after receiving a dose of 10 mg hydrocortisone and after placebo. GC administration had an enhancing effect on inhibitory performance in healthy control participants, indicated by faster responses, while no GC effect was revealed for the patients group. Moreover, patients showed an overall worse performance than healthy participants. In conclusion, this study further supports the hypothesis of impaired central glucocorticoid receptor function in MDD patients. Regarding the importance of inhibitory functioning for daily living, further studies are needed to examine the impact of glucocorticoids on response inhibition. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  15. Neuromodulation of Attentional Control in Major Depression: A Pilot DeepTMS Study

    PubMed Central

    Naim-Feil, Jodie; Bradshaw, John L.; Sheppard, Dianne M.; Rosenberg, Oded; Levkovitz, Yechiel; Fitzgerald, Paul B.; Isserles, Moshe; Zangen, Abraham

    2016-01-01

    While Major Depressive Disorder (MDD) is primarily characterized by mood disturbances, impaired attentional control is increasingly identified as a critical feature of depression. Deep transcranial magnetic stimulation (deepTMS), a noninvasive neuromodulatory technique, can modulate neural activity and induce neuroplasticity changes in brain regions recruited by attentional processes. This study examined whether acute and long-term high-frequency repetitive deepTMS to the dorsolateral prefrontal cortex (DLPFC) can attenuate attentional deficits associated with MDD. Twenty-one MDD patients and 26 matched control subjects (CS) were administered the Beck Depression Inventory and the Sustained Attention to Response Task (SART) at baseline. MDD patients were readministered the SART and depressive assessments following a single session (n = 21) and after 4 weeks (n = 13) of high-frequency (20 Hz) repetitive deepTMS applied to the DLPFC. To control for the practice effect, CS (n = 26) were readministered the SART a further two times. The MDD group exhibited deficits in sustained attention and cognitive inhibition. Both acute and long-term high-frequency repetitive frontal deepTMS ameliorated sustained attention deficits in the MDD group. Improvement after acute deepTMS was related to attentional recovery after long-term deepTMS. Longer-term improvement in sustained attention was not related to antidepressant effects of deepTMS treatment. PMID:26823985

  16. Problematic Internet use was more common in Turkish adolescents with major depressive disorders than controls.

    PubMed

    Alpaslan, Ahmet Hamdi; Soylu, Nusret; Kocak, Ugur; Guzel, Halil Ibrahim

    2016-06-01

    This study compared problematic Internet use (PIU) rates in 12- to 18-year-olds with major depressive disorder (MDD) and healthy controls and explored potential links between PIU and suicide among patients with MDD. The study sample consisted of 120 patients with MDD (62.5% girls) and 100 controls (58% girls) with a mean age of 15. Suicide ideation and suicide attempts were evaluated, and sociodemographic data were collected. In addition, the Children's Depression Inventory, Young Internet Addiction Test and Suicide Probability Scale were applied. The results showed that PIU rates were significantly higher in the MDD cases than the controls (p < 0.001). The analysis of covariance results showed that there was no relationship between potential suicide and the Young Internet Addiction Test score in MDD cases. However, the hopelessness subscale scores of the MDD patients with PIU were significantly higher than the scores of those without PIU. Our results show that PIU was higher in adolescents with MDD and hopelessness was more prevalent among MDD patients with PIU, but no links with potential suicide were found. As this study was a cross-sectional one, it did not allow us to infer a causality relationship between PIU and MDD. ©2016 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.

  17. Tick-borne diseases of bovines in Pakistan: major scope for future research and improved control.

    PubMed

    Jabbar, Abdul; Abbas, Tariq; Sandhu, Zia-ud-Din; Saddiqi, Hafiz A; Qamar, Muhammad F; Gasser, Robin B

    2015-05-22

    Ticks and tick-borne diseases (TBDs) affect the productivity of bovines in tropical and subtropical regions of the world, leading to a significant adverse impact on the livelihoods of resource-poor farming communities. Globally, four main TBDs, namely anaplasmosis, babesiosis, theileriosis, and cowdriosis (heartwater) affect bovines, and the former three are of major economic importance in bovines in Pakistan. Given that the livestock sector has become an integral part of Pakistan's economy and a large number of dairy cattle are being imported into the country, in order to meet an increasing demand of milk and milk products, it is timely to review current status of bovine TBDs in Pakistan and to identify gaps in the knowledge of TBDs and their control. Although there has been a recent increase in the number of studies of TBDs in this country, information on their prevalence, distribution, tick vectors, and control is limited. This article provides a brief background on key bovine TBDs and ticks and reviews the current status of bovine TBDs in Pakistan to identify gaps in knowledge and understanding of these diseases, propose areas for future research and draw attention to the need for improved tools for the diagnosis and control of TBDs in this country.

  18. Arabidopsis OR proteins are the major posttranscriptional regulators of phytoene synthase in controlling carotenoid biosynthesis

    PubMed Central

    Zhou, Xiangjun; Welsch, Ralf; Yang, Yong; Álvarez, Daniel; Riediger, Matthias; Yuan, Hui; Fish, Tara; Liu, Jiping; Thannhauser, Theodore W.; Li, Li

    2015-01-01

    Carotenoids are indispensable natural pigments to plants and humans. Phytoene synthase (PSY), the rate-limiting enzyme in the carotenoid biosynthetic pathway, and ORANGE (OR), a regulator of chromoplast differentiation and enhancer of carotenoid biosynthesis, represent two key proteins that control carotenoid biosynthesis and accumulation in plants. However, little is known about the mechanisms underlying their posttranscriptional regulation. Here we report that PSY and OR family proteins [Arabidopsis thaliana OR (AtOR) and AtOR-like] physically interacted with each other in plastids. We found that alteration of OR expression in Arabidopsis exerted minimal effect on PSY transcript abundance. However, overexpression of AtOR significantly increased the amount of enzymatically active PSY, whereas an ator ator-like double mutant exhibited a dramatically reduced PSY level. The results indicate that the OR proteins serve as the major posttranscriptional regulators of PSY. The ator or ator-like single mutant had little effect on PSY protein levels, which involves a compensatory mechanism and suggests partial functional redundancy. In addition, modification of PSY expression resulted in altered AtOR protein levels, corroborating a mutual regulation of PSY and OR. Carotenoid content showed a correlated change with OR-mediated PSY level, demonstrating the function of OR in controlling carotenoid biosynthesis by regulating PSY. Our findings reveal a novel mechanism by which carotenoid biosynthesis is controlled via posttranscriptional regulation of PSY in plants. PMID:25675505

  19. Pinhole/coronograph pointing control system integration and noise reduction analysis

    NASA Technical Reports Server (NTRS)

    Greene, M.

    1981-01-01

    The Pinhole Occulter Facility (P/OF) is a Space Shuttle based experiment for the production of solar coronographics and hard X-ray images. The system is basically pinhole camera utilizing a deployable 50-m flexible boom for separating the pinholes and coronograph shields from the recording devices located in the Shuttle bay. At the distal end of the boom from the Shuttle is a 25 kg mask containing pinholes and coronograph shields. At the proximal end the detectors are located and mounted, along with the deployable boom, to the ASPS gimbal pointing system (AGS). The mask must be pointed at the Sun with a high degree of pointing stability and accuracy to align the axes of the detectors with the pinholes and shields. Failure to do so will result in a blurring of the images on the detectors and a loss of resolution. Being a Shuttle based experiment, the system will be subjected to the disturbances of the Shuttle. The worst of these is thruster firing for orbit correction; the Shuttle uses a bang-bang thruster control system to maintain orbit to within preset limits. Other disturbances include man motion, motion induced by other systems, and gravity gradient torques.

  20. Waveguides with Absorbing Boundaries: Nonlinearity Controlled by an Exceptional Point and Solitons

    NASA Astrophysics Data System (ADS)

    Midya, Bikashkali; Konotop, Vladimir V.

    2017-07-01

    We reveal the existence of continuous families of guided single-mode solitons in planar waveguides with weakly nonlinear active core and absorbing boundaries. Stable propagation of TE and TM-polarized solitons is accompanied by attenuation of all other modes, i.e., the waveguide features properties of conservative and dissipative systems. If the linear spectrum of the waveguide possesses exceptional points, which occurs in the case of TM polarization, an originally focusing (defocusing) material nonlinearity may become effectively defocusing (focusing). This occurs due to the geometric phase of the carried eigenmode when the surface impedance encircles the exceptional point. In its turn, the change of the effective nonlinearity ensures the existence of dark (bright) solitons in spite of focusing (defocusing) Kerr nonlinearity of the core. The existence of an exceptional point can also result in anomalous enhancement of the effective nonlinearity. In terms of practical applications, the nonlinearity of the reported waveguide can be manipulated by controlling the properties of the absorbing cladding.

  1. Interferometric adaptive optics for high power laser pointing, wave-front control and phasing

    SciTech Connect

    Baker, K L; Stappaerts, E A; Homoelle, D C; Henesian, M A; Bliss, E S; Siders, C W; Barty, C J

    2009-01-21

    Implementing the capability to perform fast ignition experiments, as well as, radiography experiments on the National Ignition Facility (NIF) places stringent requirements on the control of each of the beam's pointing and overall wavefront quality. One quad of the NIF beams, 4 beam pairs, will be utilized for these experiments and hydrodynamic and particle-in-cell simulations indicate that for the fast ignition experiments, these beams will be required to deliver 50% (4.0 kJ) of their total energy (7.96 kJ) within a 40 {micro}m diameter spot at the end of a fast ignition cone target. This requirement implies a stringent pointing and overall phase conjugation error budget on the adaptive optics system used to correct these beam lines. The overall encircled energy requirement is more readily met by phasing of the beams in pairs but still requires high Strehl ratios, Sr, and rms tip/tilt errors of approximately one {micro}rad. To accomplish this task we have designed an interferometric adaptive optics system capable of beam pointing, high Strehl ratio and beam phasing with a single pixilated MEMS deformable mirror and interferometric wave-front sensor. We present the design of a testbed used to evaluate the performance of this wave-front sensor below along with simulations of its expected performance level.

  2. Formation Flying Satellite Control Around the L2 Sun-Earth Libration Point

    NASA Astrophysics Data System (ADS)

    Hamilton, Nicholas H.

    2001-12-01

    A growing interest in formation flying satellites demands development and analysis of control and estimation algorithms for station-keeping and formation maneuvering. This thesis discusses the development of a discrete linear-quadratic- regulator control algorithm for formations in the vicinity of the L2 sun-earth libration point. The development of an appropriate Kalman filter is included as well. Simulations are created for the analysis of the station-keeping and various formation maneuvers of the Stellar Imager mission. The simulations provide tracking error, estimation error, and control effort results. From the control effort, useful design parameters such as AV and propellant mass are determined. For formation maneuvering, the drone spacecraft track to within 4 meters of their desired position and within 1.3 millimeters per second of their desired zero velocity. The filter, with few exceptions, keeps the estimation errors within their three-sigma values. Without noise, the controller performs extremely well, with the drones tracking to within several micrometers. Bach drone uses around 1 to 2 grams of propellant per maneuver, depending on the circumstances.

  3. Formation Flying Satellite Control Around the L2 Sun-Earth Libration Point

    NASA Technical Reports Server (NTRS)

    Hamilton, Nicholas H.; Folta, David; Carpenter, Russell; Bauer, Frank (Technical Monitor)

    2002-01-01

    A growing interest in formation flying satellites demands development and analysis of control and estimation algorithms for station-keeping and formation maneuvering. This paper discusses the development of a discrete linear-quadratic-regulator control algorithm for formations in the vicinity of the L2 sun-earth libration point. The development of an appropriate Kalman filter is included as well. Simulations are created for the analysis of the station-keeping and various formation maneuvers of the Stellar Imager mission. The simulations provide tracking error, estimation error, and control effort results. From the control effort, useful design parameters such as delta V and propellant mass are determined. For formation maneuvering, the formation spacecraft track to within 4 meters of their desired position and within 1.5 millimeters per second of their desired zero velocity. The filter, with few exceptions, keeps the estimation errors within their three-sigma values. Without noise, the controller performs extremely well, with the formation spacecraft tracking to within several micrometers. Each spacecraft uses around 1 to 2 grams of propellant per maneuver, depending on the circumstances.

  4. Critical Point Facility (CPF) Team in the Spacelab Payload Operations Control Center (SL POCC)

    NASA Technical Reports Server (NTRS)

    1982-01-01

    The primary payload for Space Shuttle Mission STS-42, launched January 22, 1992, was the International Microgravity Laboratory-1 (IML-1), a pressurized manned Spacelab module. The goal of IML-1 was to explore in depth the complex effects of weightlessness of living organisms and materials processing. Around-the-clock research was performed on the human nervous system's adaptation to low gravity and effects of microgravity on other life forms such as shrimp eggs, lentil seedlings, fruit fly eggs, and bacteria. Materials processing experiments were also conducted, including crystal growth from a variety of substances such as enzymes, mercury iodide, and a virus. The Huntsville Operations Support Center (HOSC) Spacelab Payload Operations Control Center (SL POCC) at the Marshall Space Flight Center (MSFC) was the air/ground communication channel used between the astronauts and ground control teams during the Spacelab missions. Featured is the Critical Point Facility (CPF) team in the SL POCC during the IML-1 mission.

  5. [The Hazard Analysis Critical Control Point approach (HACCP) in meat production].

    PubMed

    Berends, B R; Snijders, J M

    1994-06-15

    The Hazard Analysis Critical Control Point (HACCP) approach is a method that could transform the current system of safety and quality assurance of meat into a really effective and flexible integrated control system. This article discusses the origin and the basic principles of the HACCP approach. It also discusses why the implementation of the approach is not as widespread as might be expected. It is concluded that a future implementation of the approach in the entire chain of meat production, i.e. from conception to consumption, is possible. Prerequisites are, however, that scientifically validated risk analyses become available, that future legislation forms a framework that actively supports the approach, and that all parties involved in meat production not only become convinced of the advantages, but also are trained to implement the HACCP approach with insight.

  6. Critical Point Facility (CPF) Team in the Spacelab Payload Operations Control Center (SL POCC)

    NASA Technical Reports Server (NTRS)

    1982-01-01

    The primary payload for Space Shuttle Mission STS-42, launched January 22, 1992, was the International Microgravity Laboratory-1 (IML-1), a pressurized manned Spacelab module. The goal of IML-1 was to explore in depth the complex effects of weightlessness of living organisms and materials processing. Around-the-clock research was performed on the human nervous system's adaptation to low gravity and effects of microgravity on other life forms such as shrimp eggs, lentil seedlings, fruit fly eggs, and bacteria. Materials processing experiments were also conducted, including crystal growth from a variety of substances such as enzymes, mercury iodide, and a virus. The Huntsville Operations Support Center (HOSC) Spacelab Payload Operations Control Center (SL POCC) at the Marshall Space Flight Center (MSFC) was the air/ground communication channel used between the astronauts and ground control teams during the Spacelab missions. Featured is the Critical Point Facility (CPF) team in the SL POCC during the IML-1 mission.

  7. An inverse dynamic trajectory planning for the end-point tracking control of a flexible manipulator

    SciTech Connect

    Kwon, D.S.; Babcock, S.M.; Book, W.J.

    1992-11-01

    A manipulator system that needs significantly large workspace volume and high payload capacity has greater link flexibility than typical industrial robots and teleoperators. If link flexibility is significant, position control of the manipulator`s end-effecter exhibits the nonminimum phase, noncollocated, and flexible structure system control problems. This paper addresses inverse dynamic trajectory planning issues of a flexible manipulator. The inverse dynamic equation of a flexible manipulator was solved in the time domain. By dividing the inverse system equation into the causal part and the anticausal part, the inverse dynamic method calculates the feedforward torque and the trajectories of all state variables that do not excite structural vibrations for a given end-point trajectory. Through simulation and experiment with a single-link flexible manipulator, the effectiveness of the inverse dynamic method has been demonstrated.

  8. An inverse dynamic trajectory planning for the end-point tracking control of a flexible manipulator

    SciTech Connect

    Kwon, D.S.; Babcock, S.M. ); Book, W.J. . School of Mechanical Engineering)

    1992-01-01

    A manipulator system that needs significantly large workspace volume and high payload capacity has greater link flexibility than typical industrial robots and teleoperators. If link flexibility is significant, position control of the manipulator's end-effecter exhibits the nonminimum phase, noncollocated, and flexible structure system control problems. This paper addresses inverse dynamic trajectory planning issues of a flexible manipulator. The inverse dynamic equation of a flexible manipulator was solved in the time domain. By dividing the inverse system equation into the causal part and the anticausal part, the inverse dynamic method calculates the feedforward torque and the trajectories of all state variables that do not excite structural vibrations for a given end-point trajectory. Through simulation and experiment with a single-link flexible manipulator, the effectiveness of the inverse dynamic method has been demonstrated.

  9. Critical Point Facility (CPE) Group in the Spacelab Payload Operations Control Center (SL POCC)

    NASA Technical Reports Server (NTRS)

    1992-01-01

    The primary payload for Space Shuttle Mission STS-42, launched January 22, 1992, was the International Microgravity Laboratory-1 (IML-1), a pressurized manned Spacelab module. The goal of IML-1 was to explore in depth the complex effects of weightlessness of living organisms and materials processing. Around-the-clock research was performed on the human nervous system's adaptation to low gravity and effects of microgravity on other life forms such as shrimp eggs, lentil seedlings, fruit fly eggs, and bacteria. Materials processing experiments were also conducted, including crystal growth from a variety of substances such as enzymes, mercury iodide, and a virus. The Huntsville Operations Support Center (HOSC) Spacelab Payload Operations Control Center (SL POCC) at the Marshall Space Flight Center (MSFC) was the air/ground communication channel used between the astronauts and ground control teams during the Spacelab missions. Featured is the Critical Point Facility (CPE) group in the SL POCC during STS-42, IML-1 mission.

  10. Critical Point Facility (CPE) Group in the Spacelab Payload Operations Control Center (SL POCC)

    NASA Technical Reports Server (NTRS)

    1992-01-01

    The primary payload for Space Shuttle Mission STS-42, launched January 22, 1992, was the International Microgravity Laboratory-1 (IML-1), a pressurized manned Spacelab module. The goal of IML-1 was to explore in depth the complex effects of weightlessness of living organisms and materials processing. Around-the-clock research was performed on the human nervous system's adaptation to low gravity and effects of microgravity on other life forms such as shrimp eggs, lentil seedlings, fruit fly eggs, and bacteria. Materials processing experiments were also conducted, including crystal growth from a variety of substances such as enzymes, mercury iodide, and a virus. The Huntsville Operations Support Center (HOSC) Spacelab Payload Operations Control Center (SL POCC) at the Marshall Space Flight Center (MSFC) was the air/ground communication channel used between the astronauts and ground control teams during the Spacelab missions. Featured is the Critical Point Facility (CPE) group in the SL POCC during STS-42, IML-1 mission.

  11. Higher order sliding mode control of laser pointing for orbital debris mitigation

    NASA Astrophysics Data System (ADS)

    Palosz, Arthur

    This thesis explores the use of a space-based laser to clean up small orbital debris from near Earth space. This system's challenge is to quickly and precisely aim the laser beam at very small (<1cm) and distant (<10km) moving orbital debris in the presence of parametric uncertainties and external disturbances. A mathematical model is derived for the debris position sensors, a Fast Steering Mirror (FSM), and a telescope which are used to track the orbital debris and then point and focus the laser beam onto the orbital debris. A Kalman Filter (KF) is designed to accurately track the orbital debris and generate a command signal for the controller. A second order Super Twisting Sliding Mode Controller (2-SMC) is designed to follow the command signal generated by the KF and to overcome the parametric uncertainties and external disturbances. The performance of the system is validated with a computer simulation created in MATLAB and Simulink.

  12. Adaptive robust maximum power point tracking control for perturbed photovoltaic systems with output voltage estimation.

    PubMed

    Koofigar, Hamid Reza

    2016-01-01

    The problem of maximum power point tracking (MPPT) in photovoltaic (PV) systems, despite the model uncertainties and the variations in environmental circumstances, is addressed. Introducing a mathematical description, an adaptive sliding mode control (ASMC) algorithm is first developed. Unlike many previous investigations, the output voltage is not required to be sensed and the upper bound of system uncertainties and the variations of irradiance and temperature are not required to be known. Estimating the output voltage by an update law, an adaptive-based H∞ tracking algorithm is then developed for the case the perturbations are energy-bounded. The stability analysis is presented for the proposed tracking control schemes, based on the Lyapunov stability theorem. From a comparison viewpoint, some numerical and experimental studies are also presented and discussed.

  13. Effect of bloodletting therapy at local myofascial trigger points and acupuncture at Jiaji (EX-B 2) points on upper back myofascial pain syndrome: a randomized controlled trial.

    PubMed

    Jiang, Guimei; Jia, Chao; Lin, Mode

    2016-02-01

    To observe the clinical efficacy of bloodletting therapy and acupuncture at Jiaji points for treating upper back myofascial pain syndrome (MPS), and compare this with lidocaine block therapy. A total of 66 upper back MPS patients were randomly assigned to either the treatment group or the control group in a 1: 1 ratio. The treatment group (n = 33) were treated with bloodletting therapy at local myofascial trigger points and acupuncture at Jiaji (EX-B 2) points; one treatment course consisted of five, single 20-min-treatments with a 2-day break between each treatment. The control group (n = 33) were treated with a lidocaine block at trigger points; one treatment course consisted of five sessions of lidocaine block therapy with a 2-day break between each session. The simplified McGill Scale (SF-MPQ) and tenderness threshold determination were used to assess pain before and after a course of treatment. After the third and fifth treatment, the SF-MPQ values were significantly decreased (P < 0.01) and the tenderness thresholds were significantly increased (P < 0.01) in both groups compared with before treatment. There were no significant differences in pain assessments between the two groups after three and five treatments (P > 0.05). There were five cases with minor adverse reactions reported in the control patients, while no adverse reactions were reported in the treatment group. Bloodletting therapy at local myofascial trigger points and acupuncture at Jiaji points was effective in treating upper back MPS. Clinically, bloodletting and acupuncture therapy had the same efficacy as the lidocaine block therapy, with fewer adverse reactions.

  14. Analysing and controlling the tax evasion dynamics via majority-vote model

    NASA Astrophysics Data System (ADS)

    Lima, F. W. S.

    2010-09-01

    Within the context of agent-based Monte-Carlo simulations, we study the well-known majority-vote model (MVM) with noise applied to tax evasion on simple square lattices, Voronoi-Delaunay random lattices, Barabasi-Albert networks, and Erdös-Rényi random graphs. In the order to analyse and to control the fluctuations for tax evasion in the economics model proposed by Zaklan, MVM is applied in the neighborhod of the noise critical qc to evolve the Zaklan model. The Zaklan model had been studied recently using the equilibrium Ising model. Here we show that the Zaklan model is robust because this can be studied using equilibrium dynamics of Ising model also through the nonequilibrium MVM and on various topologies cited above giving the same behavior regardless of dynamic or topology used here.

  15. Hygienic-dietary recommendations for major depression treatment: Study protocol of a randomized controlled trial

    PubMed Central

    2012-01-01

    Background Depression is a highly prevalent and disabling mental disorder with an incidence rate which appears to be increasing in the developed world. This fact seems to be at least partially related to lifestyle factors. Some hygienic-dietary measures have shown their efficacy as a coadjuvant of standard treatment. However, their effectiveness has not yet been proved enough in usual clinical practice. Methods Multicenter, randomized, controlled, two arm-parallel, clinical trial involving 300 patients over 18 years old with a diagnosis of Major Depression. Major depression will be diagnosed by means of the Mini-International Neuropsychiatric Interview. The Beck Depression Inventory total score at the end of the study will constitute the main efficacy outcome. Quality of Life and Social and Health Care Services Consumption Scales will be also administered. Patients will be assessed at three different occasions: baseline, 6-month follow-up and 12-month follow-up. Discussion We expect the patients in the active lifestyle recommendations group to experience a greater improvement in their depressive symptoms and quality of life with lower socio-sanitary costs. Trial registration ISRCTN73931675 PMID:23158080

  16. Major QTLs control resistance to rice hoja blanca virus and its vector Tagosodes orizicolus.

    PubMed

    Romero, Luz E; Lozano, Ivan; Garavito, Andrea; Carabali, Silvio J; Triana, Monica; Villareal, Natalia; Reyes, Luis; Duque, Myriam C; Martinez, César P; Calvert, Lee; Lorieux, Mathias

    2014-01-10

    Rice hoja blanca (white leaf) disease can cause severe yield losses in rice in the Americas. The disease is caused by the rice hoja blanca virus (RHBV), which is transmitted by the planthopper vector Tagosodes orizicolus. Because classical breeding schemes for this disease rely on expensive, time-consuming screenings, there is a need for alternatives such as marker-aided selection. The varieties Fedearroz 2000 and Fedearroz 50, which are resistant to RHBV and to the feeding damage caused by T. orizicolus, were crossed with the susceptible line WC366 to produce segregating F2:3 populations. The F3 families were scored for their resistance level to RHBV and T. orizicolus. The F2:3 lines of both crosses were genotyped using microsatellite markers. One major QTL on the short arm of chromosome 4 was identified for resistance to RHBV in the two populations. Two major QTL on chromosomes 5 and 7 were identified for resistance to T. orizicolus in the Fd2000 × WC366 and Fd50 × WC366 crosses, respectively. This comparative study using two distinct rice populations allowed for a better understanding of how the resistance to RHBV and its vector are controlled genetically. Simple marker-aided breeding schemes based on QTL information can be designed to improve rice germplasm to reduce losses caused by this important disease.

  17. A major QTL controls susceptibility to spinal curvature in the curveback guppy

    PubMed Central

    2011-01-01

    Background Understanding the genetic basis of heritable spinal curvature would benefit medicine and aquaculture. Heritable spinal curvature among otherwise healthy children (i.e. Idiopathic Scoliosis and Scheuermann kyphosis) accounts for more than 80% of all spinal curvatures and imposes a substantial healthcare cost through bracing, hospitalizations, surgery, and chronic back pain. In aquaculture, the prevalence of heritable spinal curvature can reach as high as 80% of a stock, and thus imposes a substantial cost through production losses. The genetic basis of heritable spinal curvature is unknown and so the objective of this work is to identify quantitative trait loci (QTL) affecting heritable spinal curvature in the curveback guppy. Prior work with curveback has demonstrated phenotypic parallels to human idiopathic-type scoliosis, suggesting shared biological pathways for the deformity. Results A major effect QTL that acts in a recessive manner and accounts for curve susceptibility was detected in an initial mapping cross on LG 14. In a second cross, we confirmed this susceptibility locus and fine mapped it to a 5 cM region that explains 82.6% of the total phenotypic variance. Conclusions We identify a major QTL that controls susceptibility to curvature. This locus contains over 100 genes, including MTNR1B, a candidate gene for human idiopathic scoliosis. The identification of genes associated with heritable spinal curvature in the curveback guppy has the potential to elucidate the biological basis of spinal curvature among humans and economically important teleosts. PMID:21269476

  18. Interpersonal psychotherapy (IPT) for major depression following perinatal loss: a pilot randomized controlled trial.

    PubMed

    Johnson, Jennifer E; Price, Ann Back; Kao, Jennifer Chienwen; Fernandes, Karen; Stout, Robert; Gobin, Robyn L; Zlotnick, Caron

    2016-10-01

    This randomized controlled pilot trial examined the feasibility, acceptability, and preliminary efficacy of an adapted interpersonal psychotherapy (IPT) for major depressive disorder (MDD) following perinatal loss (miscarriage, stillbirth, or early neonatal death). Fifty women who experienced a perinatal loss within the past 18 months, whose current depressive episode onset occurred during or after the loss, were randomized to the group IPT adapted for perinatal loss (the Group IPT for Major Depression Following Perinatal Loss manual developed for this study is available at no cost by contacting either of the first two authors) or to the group Coping with Depression (CWD), a cognitive behavioral treatment which did not focus on perinatal loss nor social support. Assessments occurred at baseline, treatment weeks 4 and 8, post-treatment, and 3 and 6 months after the end of treatment. IPT was feasible and acceptable in this population. Although some participants were initially hesitant to discuss their losses in a group (as occurred in IPT but not CWD), end of treatment satisfaction scores were significantly (p = 0.001) higher in IPT than in CWD. Confidence intervals around between-groups effect sizes favored IPT for reductions in depressive symptoms during treatment as well as for improvement in mode-specific targets (social support, grief symptoms) and recovery from a post-traumatic stress disorder over follow-up. This group IPT treatment adapted for MDD after perinatal loss is feasible, acceptable, and possibly efficacious.

  19. Identification of a major QTL controlling the content of B-type starch granules in Aegilops

    PubMed Central

    Howard, Thomas; Rejab, Nur Ardiyana; Griffiths, Simon; Leigh, Fiona; Leverington-Waite, Michelle; Simmonds, James; Uauy, Cristobal; Trafford, Kay

    2011-01-01

    Starch within the endosperm of most species of the Triticeae has a unique bimodal granule morphology comprising large lenticular A-type granules and smaller near-spherical B-type granules. However, a few wild wheat species (Aegilops) are known to lack B-granules. Ae. peregrina and a synthetic tetraploid Aegilops with the same genome composition (SU) were found to differ in B-granule number. The synthetic tetraploid had normal A- and B-type starch granules whilst Ae. peregrina had only A-granules because the B-granules failed to initiate. A population segregating for B-granule number was generated by crossing these two accessions and was used to study the genetic basis of B-granule initiation. A combination of Bulked Segregant Analysis and QTL mapping identified a major QTL located on the short arm of chromosome 4S that accounted for 44.4% of the phenotypic variation. The lack of B-granules in polyploid Aegilops with diverse genomes suggests that the B-granule locus has been lost several times independently during the evolution of the Triticeae. It is proposed that the B-granule locus is susceptible to silencing during polyploidization and a model is presented to explain the observed data based on the assumption that the initiation of B-granules is controlled by a single major locus per haploid genome. PMID:21227932

  20. Major QTLs Control Resistance to Rice Hoja Blanca Virus and Its Vector Tagosodes orizicolus

    PubMed Central

    Romero, Luz E.; Lozano, Ivan; Garavito, Andrea; Carabali, Silvio J.; Triana, Monica; Villareal, Natalia; Reyes, Luis; Duque, Myriam C.; Martinez, César P.; Calvert, Lee; Lorieux, Mathias

    2013-01-01

    Rice hoja blanca (white leaf) disease can cause severe yield losses in rice in the Americas. The disease is caused by the rice hoja blanca virus (RHBV), which is transmitted by the planthopper vector Tagosodes orizicolus. Because classical breeding schemes for this disease rely on expensive, time-consuming screenings, there is a need for alternatives such as marker-aided selection. The varieties Fedearroz 2000 and Fedearroz 50, which are resistant to RHBV and to the feeding damage caused by T. orizicolus, were crossed with the susceptible line WC366 to produce segregating F2:3 populations. The F3 families were scored for their resistance level to RHBV and T. orizicolus. The F2:3 lines of both crosses were genotyped using microsatellite markers. One major QTL on the short arm of chromosome 4 was identified for resistance to RHBV in the two populations. Two major QTL on chromosomes 5 and 7 were identified for resistance to T. orizicolus in the Fd2000 × WC366 and Fd50 × WC366 crosses, respectively. This comparative study using two distinct rice populations allowed for a better understanding of how the resistance to RHBV and its vector are controlled genetically. Simple marker-aided breeding schemes based on QTL information can be designed to improve rice germplasm to reduce losses caused by this important disease. PMID:24240781

  1. Acupuncture point injection treatment of primary dysmenorrhoea: a randomised, double blind, controlled study

    PubMed Central

    Wade, C; Wang, L; Zhao, W J; Cardini, F; Kronenberg, F; Gui, S Q; Ying, Z; Zhao, N Q; Chao, M T; Yu, J

    2016-01-01

    Objective To determine if injection of vitamin K3 in an acupuncture point is optimal for the treatment of primary dysmenorrhoea, when compared with 2 other injection treatments. Setting A Menstrual Disorder Centre at a public hospital in Shanghai, China. Participants Chinese women aged 14–25 years with severe primary dysmenorrhoea for at least 6 months not relieved by any other treatment were recruited. Exclusion criteria were the use of oral contraceptives, intrauterine devices or anticoagulant drugs, pregnancy, history of abdominal surgery, participation in other therapies for pain and diagnosis of secondary dysmenorrhoea. Eighty patients with primary dysmenorrhoea, as defined on a 4-grade scale, completed the study. Two patients withdrew after randomisation. Interventions A double-blind, double-dummy, randomised controlled trial compared vitamin K3 acupuncture point injection to saline acupuncture point injection and vitamin K3 deep muscle injection. Patients in each group received 3 injections at a single treatment visit. Primary and secondary outcome measures The primary outcome was the difference in subjective perception of pain as measured by an 11 unit Numeric Rating Scale (NRS). Secondary measurements were Cox Pain Intensity and Duration scales and the consumption of analgesic tablets before and after treatment and during 6 following cycles. Results Patients in all 3 groups experienced pain relief from the injection treatments. Differences in NRS measured mean pain scores between the 2 active control groups were less than 1 unit (−0.71, CI −1.37 to −0.05) and not significant, but the differences in average scores between the treatment hypothesised to be optimal and both active control groups (1.11, CI 0.45 to 1.78) and (1.82, CI 1.45 to 2.49) were statistically significant in adjusted mixed-effects models. Menstrual distress and use of analgesics were diminished for 6 months post-treatment. Conclusions Acupuncture point injection of

  2. Acupuncture point injection treatment of primary dysmenorrhoea: a randomised, double blind, controlled study.

    PubMed

    Wade, C; Wang, L; Zhao, W J; Cardini, F; Kronenberg, F; Gui, S Q; Ying, Z; Zhao, N Q; Chao, M T; Yu, J

    2016-01-05

    To determine if injection of vitamin K3 in an acupuncture point is optimal for the treatment of primary dysmenorrhoea, when compared with 2 other injection treatments. A Menstrual Disorder Centre at a public hospital in Shanghai, China. Chinese women aged 14-25 years with severe primary dysmenorrhoea for at least 6 months not relieved by any other treatment were recruited. Exclusion criteria were the use of oral contraceptives, intrauterine devices or anticoagulant drugs, pregnancy, history of abdominal surgery, participation in other therapies for pain and diagnosis of secondary dysmenorrhoea. Eighty patients with primary dysmenorrhoea, as defined on a 4-grade scale, completed the study. Two patients withdrew after randomisation. A double-blind, double-dummy, randomised controlled trial compared vitamin K3 acupuncture point injection to saline acupuncture point injection and vitamin K3 deep muscle injection. Patients in each group received 3 injections at a single treatment visit. The primary outcome was the difference in subjective perception of pain as measured by an 11 unit Numeric Rating Scale (NRS). Secondary measurements were Cox Pain Intensity and Duration scales and the consumption of analgesic tablets before and after treatment and during 6 following cycles. Patients in all 3 groups experienced pain relief from the injection treatments. Differences in NRS measured mean pain scores between the 2 active control groups were less than 1 unit (-0.71, CI -1.37 to -0.05) and not significant, but the differences in average scores between the treatment hypothesised to be optimal and both active control groups (1.11, CI 0.45 to 1.78) and (1.82, CI 1.45 to 2.49) were statistically significant in adjusted mixed-effects models. Menstrual distress and use of analgesics were diminished for 6 months post-treatment. Acupuncture point injection of vitamin K3 relieves menstrual pain rapidly and is a useful treatment in an urban outpatient clinic. NCT00104546; Results

  3. Screening for the synthetic cannabinoid JWH-018 and its major metabolites in human doping controls.

    PubMed

    Möller, Ines; Wintermeyer, Annette; Bender, Katja; Jübner, Martin; Thomas, Andreas; Krug, Oliver; Schänzer, Wilhelm; Thevis, Mario

    2011-09-01

    Referred to as 'spice', several new drugs, advertised as herbal blends, have appeared on the market in the last few years, in which the synthetic cannabinoids JWH-018 and a C(8) homologue of CP 47,497 were identified as major active ingredients. Due to their reported cannabis-like effects, many European countries have banned these substances. The World Anti-Doping Agency has also explicitly prohibited synthetic cannabinoids in elite sport in-competition. Since urine specimens have been the preferred doping control samples, the elucidation of the metabolic pathways of these substances is of particular importance to implement them in sports drug testing programmes. In a recent report, an in vitro phase-I metabolism study of JWH-018 was presented yielding mainly hydroxylated and N-dealkylated metabolites. Due to these findings, a urine sample of a healthy man declaring to have smoked a 'spice' product was screened for potential phase-I and -II metabolites by high-resolution/high-accuracy mass spectrometry in the present report. The majority of the phase-I metabolites observed in earlier in vitro studies of JWH-018 were detected in this urine specimen and furthermore most of their respective monoglucuronides. As no intact JWH-018 was detectable, the monohydroxylated metabolite being the most abundant one was chosen as a target analyte for sports drug testing purposes; a detection method was subsequently developed and validated in accordance to conventional screening protocols based on enzymatic hydrolysis, liquid-liquid extraction, and liquid chromatography/electrospray tandem mass spectrometry analysis. The method was applied to approximately 7500 urine doping control samples yielding two JWH-018 findings and demonstrated its capability for a sensitive and selective identification of JWH-018 and its metabolites in human urine. Copyright © 2010 John Wiley & Sons, Ltd.

  4. A novel target LOS calibration method for IR scanning sensor based on control points

    NASA Astrophysics Data System (ADS)

    Xue, Yong-Hong; An, Wei; Zhang, Yin-Sheng; Zhang, Tao

    2012-12-01

    Space based IR system uses the information of target LOS (line of sight) for target location. Recent researches show that the measuring precision of target LOS is usually determined by measuring precision of platform's position and attitude, and deformation of sensor etc. Most methods for improving target location precision are either through improving platform's position and attitude measuring precision or through calib rating the whole image obtained by IR sensor. With the development of measuring technology, it is harder to make a further improvement on the measuring precision of position and attitude of the platform and the expansion of the sensor view make calibrat ion of the whole image with a larger computation cost. In this paper, a method using control points to calibrate target LOS was proposed. Based on the analysis of the imaging process of the scanning sensor of space based IR system, this paper established a modify model of target LOS based on control points, used a bias filter to estimate the bias value of sensor boresight, and finally achieved the mission of target LOS calibrat ion. Different from the traditional calibration method of remote sensing image, the proposed method only made a correct ion on the LOS of suspicious target, but not established the accurate relationship between the all pixels and their real location, and has a similar calibration performance, but more lower computational complexity.

  5. Real-time gesture recognition by learning and selective control of visual interest points.

    PubMed

    Kirishima, Toshiyuki; Sato, Kosuke; Chihara, Kunihiro

    2005-03-01

    For the real-time recognition of unspecified gestures by an arbitrary person, a comprehensive framework is presented that addresses two important problems in gesture recognition systems: selective attention and processing frame rate. To address the first problem, we propose the Quadruple Visual Interest Point Strategy. No assumptions are made with regard to scale or rotation of visual features, which are computed from dynamically changing regions of interest in a given image sequence. In this paper, each of the visual features is referred to as a visual interest point, to which a probability density function is assigned, and the selection is carried out. To address the second problem, we developed a selective control method to equip the recognition system with self-load monitoring and controlling functionality. Through evaluation experiments, we show that our approach provides robust recognition with respect to such factors as type of clothing, type of gesture, extent of motion trajectories, and individual differences in motion characteristics. In order to indicate the real-time performance and utility aspects of our approach, a gesture video system is developed that demonstrates full video-rate interaction with displayed image objects.

  6. Research on the modeling of the missile's disturbance motion and the initial control point optimization

    NASA Astrophysics Data System (ADS)

    Guo, Jie; Zhu, Dalin; Tang, Shengjing

    2012-11-01

    The initial trajectory design of the missile is an important part of the overall design, but often a tedious calculation and analysis process due to the large dimension nonlinear differential equations and the traditional statistical analysis methods. To improve the traditional design methods, a robust optimization concept and method are introduced in this paper to deal with the determination of the initial control point. First, the Gaussian Radial Basis Network is adopted to establish the approximate model of the missile's disturbance motion based on the disturbance motion and disturbance factors analysis. Then, a direct analytical relationship between the disturbance input and statistical results is deduced on the basis of Gaussian Radial Basis Network model. Subsequently, a robust optimization model is established aiming at the initial control point design problem and the niche Pareto genetic algorithm for multi-objective optimization is adopted to solve this optimization model. An integral design example is give at last and the simulation results have verified the validity of this method.

  7. Method for pan-tilt camera calibration using single control point.

    PubMed

    Li, Yunting; Zhang, Jun; Hu, Wenwen; Tian, Jinwen

    2015-01-01

    The pan-tilt (PT) camera is widely used in video surveillance systems due to its rotatable property and low cost. The rough output of a PT camera may not satisfy the demand of practical applications; hence an accurate calibration method of a PT camera is desired. However, high-precision camera calibration methods usually require sufficient control points not guaranteed in some practical cases of a PT camera. In this paper, we present a novel method to online calibrate the rotation angles of a PT camera by using only one control point. This is achieved by assuming that the intrinsic parameters and position of the camera are known in advance. More specifically, we first build a nonlinear PT camera model with respect to two parameters Pan and Tilt. We then convert the nonlinear model into a linear model according to sine and cosine of Tilt, where each element in the augmented coefficient matrix is a function of the single variable Pan. A closed-form solution of Pan and Tilt can then be derived by solving a quadratic equation of tangent of Pan. Our method is noniterative and does not need features matching; thus its time efficiency is better. We evaluate our calibration method on various synthetic and real data. The quantitative results demonstrate that the proposed method outperforms other state-of-the-art methods if the intrinsic parameters and position of the camera are known in advance.

  8. Morphological control in polymer solar cells using low-boiling-point solvent additives

    NASA Astrophysics Data System (ADS)

    Mahadevapuram, Rakesh C.

    In the global search for clean, renewable energy sources, organic photovoltaics (OPVs) have recently been given much attention. Popular modern-day OPVs are made from solution-processible, carbon-based polymers (e.g. the model poly(3-hexylthiophene) that are intimately blended with fullerene derivatives (e.g. [6,6]-phenyl-C71-butyric acid methyl ester) to form what is known as the dispersed bulk-heterojunction (BHJ). This BHJ architecture has produced some of the most efficient OPVs to date, with reports closing in on 10% power conversion efficiency. To push efficiencies further into double digits, many groups have identified the BHJ nanomorphology---that is, the phase separations and grain sizes within the polymer: fullerene composite---as a key aspect in need of control and improvement. As a result, many methods, including thermal annealing, slow-drying (solvent) annealing, vapor annealing, and solvent additives, have been developed and studied to promote BHJ self-organization. Processing organic photovoltaic (OPV) blend solutions with high-boiling-point solvent additives has recently been used for morphological control in BHJ OPV cells. Here we show that even low-boiling-point solvents can be effective additives. When P3HT:PCBM OPV cells were processed with a low-boiling-point solvent tetrahydrafuran as an additive in parent solvent o-dichlorobenzene, charge extraction increased leading to fill factors as high as 69.5%, without low work-function cathodes, electrode buffer layers or thermal treatment. This was attributed to PCBM demixing from P3HT domains and better vertical phase separation, as indicated by photoluminescence lifetimes, hole mobilities, and shunt leakage currents. Dependence on solvent parameters and applicability beyond P3HT system was also investigated.

  9. Realization of tin freezing point using a loop heat pipe-based hydraulic temperature control technique

    NASA Astrophysics Data System (ADS)

    Joung, Wukchul; Gam, Kee Sool; Kim, Yong-Gyoo

    2015-10-01

    In this work, the freezing point of tin (Sn FP) was realized by inside nucleation where the supercooling of tin and the reheating of the sample after the nucleation were achieved without extracting the cell from an isothermal apparatus. To this end, a novel hydraulic temperature control technique, which was based on the thermo-hydraulic characteristics of a pressure-controlled loop heat pipe (LHP), was employed to provide a slow cooling of the sample for deep supercooling and fast reheating after nucleation to minimize the amount of initial freeze of the sample. The required temperature controls were achieved by the active pressure control of a control gas inside the compensation chamber of the pressure-controlled LHP, and slow cooling at  -0.05 K min-1 for the deep supercooling of tin and fast heating at 2 K min-1 for reheating the sample after nucleation was attained. Based on this hydraulic temperature control technique, the nucleation of tin was realized at supercooling of around 19 K, and a satisfactorily fast reheating of the sample to the plateau-producing temperature (i.e. 0.5 K below the Sn FP) was achieved without any temperature overshoots of the isothermal region. The inside-nucleated Sn FP showed many desirable features compared to the Sn FP realized by the conventional outside nucleation method. The longer freezing plateaus and the better immersion characteristics of the Sn FP were obtained by inside nucleation, and the measured freezing temperature of the inside-nucleated Sn FP was as much as 0.37 mK higher than the outside-nucleated Sn FP with an expanded uncertainty of 0.19 mK. Details on the experiment are provided and explanations for the observed differences are discussed.

  10. Neural set point for the control of arterial pressure: role of the nucleus tractus solitarius

    PubMed Central

    2010-01-01

    Background Physiological experiments have shown that the mean arterial blood pressure (MAP) can not be regulated after chemo and cardiopulmonary receptor denervation. Neuro-physiological information suggests that the nucleus tractus solitarius (NTS) is the only structure that receives information from its rostral neural nuclei and from the cardiovascular receptors and projects to nuclei that regulate the circulatory variables. Methods From a control theory perspective, to answer if the cardiovascular regulation has a set point, we should find out whether in the cardiovascular control there is something equivalent to a comparator evaluating the error signal (between the rostral projections to the NTS and the feedback inputs). The NTS would function as a comparator if: a) its lesion suppresses cardiovascular regulation; b) the negative feedback loop still responds normally to perturbations (such as mechanical or electrical) after cutting the rostral afferent fibers to the NTS; c) perturbation of rostral neural structures (RNS) to the NTS modifies the set point without changing the dynamics of the elicited response; and d) cardiovascular responses to perturbations on neural structures within the negative feedback loop compensate for much faster than perturbations on the NTS rostral structures. Results From the control theory framework, experimental evidence found currently in the literature plus experimental results from our group was put together showing that the above-mentioned conditions (to show that the NTS functions as a comparator) are satisfied. Conclusions Physiological experiments suggest that long-term blood pressure is regulated by the nervous system. The NTS functions as a comparator (evaluating the error signal) between its RNS and the cardiovascular receptor afferents and projects to nuclei that regulate the circulatory variables. The mean arterial pressure (MAP) is regulated by the feedback of chemo and cardiopulmonary receptors and the baroreflex

  11. Measuring the distance from saddle points and driving to locate them over quantum control landscapes

    NASA Astrophysics Data System (ADS)

    Sun, Qiuyang; Riviello, Gregory; Wu, Re-Bing; Rabitz, Herschel

    2015-11-01

    Optimal control of quantum phenomena involves the introduction of a cost functional J to characterize the degree of achieving a physical objective by a chosen shaped electromagnetic field. The cost functional dependence upon the control forms a control landscape. Two theoretically important canonical cases are the landscapes associated with seeking to achieve either a physical observable or a unitary transformation. Upon satisfaction of particular assumptions, both landscapes are analytically known to be trap-free, yet possess saddle points at precise suboptimal J values. The presence of saddles on the landscapes can influence the effort needed to find an optimal field. As a foundation to future algorithm development and analyzes, we define metrics that identify the ‘distance’ from a given saddle based on the sufficient and necessary conditions for the existence of the saddles. Algorithms are introduced utilizing the metrics to find a control such that the dynamics arrive at a targeted saddle. The saddle distance metric and saddle-seeking methodology is tested numerically in several model systems.

  12. Binocular and Monocular Depth Cues in Online Feedback Control of 3-D Pointing Movement

    PubMed Central

    Hu, Bo; Knill, David C.

    2012-01-01

    Previous work has shown that humans continuously use visual feedback of the hand to control goal-directed movements online. In most studies, visual error signals were predominantly in the image plane and thus were available in an observer’s retinal image. We investigate how humans use visual feedback about finger depth provided by binocular and monocular depth cues to control pointing movements. When binocularly viewing a scene in which the hand movement was made in free space, subjects were about 60 ms slower in responding to perturbations in depth than in the image plane. When monocularly viewing a scene designed to maximize the available monocular cues to finger depth (motion, changing size and cast shadows), subjects showed no response to perturbations in depth. Thus, binocular cues from the finger are critical to effective online control of hand movements in depth. An optimal feedback controller that takes into account of the low peripheral stereoacuity and inherent ambiguity in cast shadows can explain the difference in response time in the binocular conditions and lack of response in monocular conditions. PMID:21724567

  13. Binocular and monocular depth cues in online feedback control of 3D pointing movement.

    PubMed

    Hu, Bo; Knill, David C

    2011-06-30

    Previous work has shown that humans continuously use visual feedback of the hand to control goal-directed movements online. In most studies, visual error signals were predominantly in the image plane and, thus, were available in an observer's retinal image. We investigate how humans use visual feedback about finger depth provided by binocular and monocular depth cues to control pointing movements. When binocularly viewing a scene in which the hand movement was made in free space, subjects were about 60 ms slower in responding to perturbations in depth than in the image plane. When monocularly viewing a scene designed to maximize the available monocular cues to finger depth (motion, changing size, and cast shadows), subjects showed no response to perturbations in depth. Thus, binocular cues from the finger are critical to effective online control of hand movements in depth. An optimal feedback controller that takes into account the low peripheral stereoacuity and inherent ambiguity in cast shadows can explain the difference in response time in the binocular conditions and lack of response in monocular conditions.

  14. Sertraline for Major Depression During the Year Following Traumatic Brain Injury: A Randomized Controlled Trial.

    PubMed

    Fann, Jesse R; Bombardier, Charles H; Temkin, Nancy; Esselman, Peter; Warms, Catherine; Barber, Jason; Dikmen, Sureyya

    2017-05-17

    Major depressive disorder (MDD) is common and associated with impaired functioning after traumatic brain injury (TBI). Few placebo-controlled antidepressant trials exist in this population. We evaluated the efficacy and tolerability of sertraline for MDD within 1 year of sustaining a TBI. Level I trauma center. Adults with MDD within 1 year of hospitalization for complicated mild to severe TBI. Randomized, double-blind, placebo-controlled trial. Twelve-week treatment response on the 17-item Hamilton Depression Rating Scale. We also assessed symptom improvement and remission. We randomized 62 participants: 32% sustained a severe TBI, 68% had significant anxiety, 63% had a history of prior MDD, and 69% had a history of alcohol or drug dependence. Depression significantly improved from baseline to 12 weeks in both treatment groups (P < .001). There were no significant differences between the sertraline and placebo groups over 12 weeks on depression severity, response, or remission. The sertraline group had significant improvement on speed of information processing compared with the placebo group (P < .006). Sertraline monotherapy was not superior to placebo for MDD in people with post-acute complicated mild to severe TBI. Research is needed on the effectiveness of interventions that also address the significant psychosocial needs of this population.

  15. Use of hazard analysis critical control point and alternative treatments in the production of apple cider.

    PubMed

    Senkel, I A; Henderson, R A; Jolbitado, B; Meng, J

    1999-07-01

    The purpose of this study was to evaluate the practices of Maryland cider producers and determine whether implementing hazard analysis critical control point (HACCP) would reduce the microbial contamination of cider. Cider producers (n = 11) were surveyed to determine existing manufacturing practices and sanitation. A training program was then conducted to inform operators of safety issues, including contamination with Escherichia coli O157:H7, and teach HACCP concepts and principles, sanitation procedures, and good manufacturing practice (GMP). Although all operators used a control strategy from one of the model HACCP plans provided, only one developed a written HACCP plan. None developed specific GMP, sanitation standard operating procedures, or sanitation monitoring records. Six operators changed or added production controls, including the exclusion of windfall apples, sanitizing apples chemically and by hot dip, and cider treatment with UV light or pasteurization. Facility inspections indicated improved sanitation and hazard control but identified ongoing problems. Microbiological evaluation of bottled cider before and after training, in-line apples, pomace, cider, and inoculated apples was conducted. E. coli O157:H7, Salmonella, or Staphylococcus aureus were not found in samples of in-line apple, pomace, and cider, or bottled cider. Generic E. coli was not isolated on in-coming apples but was found in 4 of 32 (13%) in-line samples and 3 of 17 (18%) bottled fresh cider samples, suggesting that E. coli was introduced during in-plant processing. To produce pathogen-free cider, operators must strictly conform to GMP and sanitation procedures in addition to HACCP controls. Controls aimed at preventing or eliminating pathogens on source apples are critical but alone may not be sufficient for product safety.

  16. Control of sediment concentration in major rivers of the Nepal Himalayas

    NASA Astrophysics Data System (ADS)

    Crave, A.; Andermann, C.; Gloaguen, R.; Bonnet, S.

    2010-12-01

    Sediment concentration in river systems of active mountain belts is key indicators to estimate present-day erosion rates. Erosion in the Himalayas is mainly controlled by the annual recurrence and intensity of the Indian summer monsoon system. But nevertheless short lasting events can be responsible for more than the half of the material transported. Temporal variability in concentration is attributed by changes of discharge and hence access to different supply sources as well as alteration of mobilization properties. Controlling factors are precipitation rates and intensities, vegetation cover, duration and limit of annual snow cover as well as seismic events. Today remotely sensed area-wide measurements are available to relate single observable events, such as extreme suspended sediment concentration peaks to their eventual sources. Due to the distinct seasonality, Himalayan rivers experience a distinct annual hydrographe which is highly repetitive. These annual flood cycles cause seasonal hysteresis loops in suspended concentration engraved by short events. Here we present a study on several major rivers in the Nepal Himalayas analyzing there discharge - sediment concentration relationship and its relation with upstream controlling properties, detected by remote sensing. Due to political unsteadiness and difficult accessible terrain, river gauging stations are rare and data not always available. Our station data covers nearly all major rivers, spanning a rainfall gradient from East to West along the Himalayan front. The average annual increase of discharge during monsoon is 1 to two magnitudes with respect to winter baseflow. Considerable Suspended concentrations (100 - 1000 g/l) are observable only within the monsoon season. Short lasting events however can catapult concentration for few short periods above 103 g/l. The occurrence of such events is commonly before peak discharge and its frequency varies from year to year. In same cases one or two events account

  17. A modular planar robotic manipulandum with end-point torque control.

    PubMed

    Howard, Ian S; Ingram, James N; Wolpert, Daniel M

    2009-07-30

    Robotic manipulanda are extensively used in investigation of the motor control of human arm movements. They permit the application of translational forces to the arm based on its state and can be used to probe issues ranging from mechanisms of neural control to biomechanics. However, most current designs are optimized for studying either motor learning or stiffness. Even fewer include end-point torque control which is important for the simulation of objects and the study of tool use. Here we describe a modular, general purpose, two-dimensional planar manipulandum (vBOT) primarily optimized for dynamic learning paradigms. It employs a carbon fibre arm arranged as a parallelogram which is driven by motors via timing pulleys. The design minimizes the intrinsic dynamics of the manipulandum without active compensation. A novel variant of the design (WristBOT) can apply torques at the handle using an add-on cable drive mechanism. In a second variant (StiffBOT) a more rigid arm can be substituted and zero backlash belts can be used, making the StiffBOT more suitable for the study of stiffness. The three variants can be used with custom built display rigs, mounting, and air tables. We investigated the performance of the vBOT and its variants in terms of effective end-point mass, viscosity and stiffness. Finally we present an object manipulation task using the WristBOT. This demonstrates that subjects can perceive the orientation of the principal axis of an object based on haptic feedback arising from its rotational dynamics.

  18. Relapse prevention in major depressive disorder: Mindfulness-based cognitive therapy versus an active control condition.

    PubMed

    Shallcross, Amanda J; Gross, James J; Visvanathan, Pallavi D; Kumar, Niketa; Palfrey, Amy; Ford, Brett Q; Dimidjian, Sona; Shirk, Stephen; Holm-Denoma, Jill; Goode, Kari M; Cox, Erica; Chaplin, William; Mauss, Iris B

    2015-10-01

    We evaluated the comparative effectiveness of mindfulness-based cognitive therapy (MBCT) versus an active control condition (ACC) for depression relapse prevention, depressive symptom reduction, and improvement in life satisfaction. Ninety-two participants in remission from major depressive disorder with residual depressive symptoms were randomized to either an 8-week MBCT or a validated ACC that is structurally equivalent to MBCT and controls for nonspecific effects (e.g., interaction with a facilitator, perceived social support, treatment outcome expectations). Both interventions were delivered according to their published manuals. Intention-to-treat analyses indicated no differences between MBCT and ACC in depression relapse rates or time to relapse over a 60-week follow-up. Both groups experienced significant and equal reductions in depressive symptoms and improvements in life satisfaction. A significant quadratic interaction (Group × Time) indicated that the pattern of depressive symptom reduction differed between groups. The ACC experienced immediate symptom reduction postintervention and then a gradual increase over the 60-week follow-up. The MBCT group experienced a gradual linear symptom reduction. The pattern for life satisfaction was identical but only marginally significant. MBCT did not differ from an ACC on rates of depression relapse, symptom reduction, or life satisfaction, suggesting that MBCT is no more effective for preventing depression relapse and reducing depressive symptoms than the active components of the ACC. Differences in trajectory of depressive symptom improvement suggest that the intervention-specific skills acquired may be associated with differential rates of therapeutic benefit. This study demonstrates the importance of comparing psychotherapeutic interventions to active control conditions. (c) 2015 APA, all rights reserved).

  19. Internet-based cognitive behavior therapy for major depressive disorder: A randomized controlled trial.

    PubMed

    Rosso, Isabelle M; Killgore, William D S; Olson, Elizabeth A; Webb, Christian A; Fukunaga, Rena; Auerbach, Randy P; Gogel, Hannah; Buchholz, Jennifer L; Rauch, Scott L

    2017-03-01

    Prior research has shown that the Sadness Program, a technician-assisted Internet-based cognitive behavioral therapy (iCBT) intervention developed in Australia, is effective for treating major depressive disorder (MDD). The current study aimed to expand this work by adapting the protocol for an American population and testing the Sadness Program with an attention control group. In this parallel-group, randomized controlled trial, adult MDD participants (18-45 years) were randomized to a 10-week period of iCBT (n = 37) or monitored attention control (MAC; n = 40). Participants in the iCBT group completed six online therapy lessons, which included access to content summaries and homework assignments. During the 10-week trial, iCBT and MAC participants logged into the web-based system six times to complete self-report symptom scales, and a nonclinician technician contacted participants weekly to provide encouragement and support. The primary outcome was the Hamilton Rating Scale for Depression (HRSD), and the secondary outcomes were the Patient Health Questionnaire-9 and Kessler-10. Intent-to-treat analyses revealed significantly greater reductions in depressive symptoms in iCBT compared with MAC participants, using both the self-report measures and the clinician-rated HRSD (d = -0.80). Importantly, iCBT participants also showed significantly higher rates of clinical response and remission. Exploratory analyses did not support illness severity as a moderator of treatment outcome. The Sadness Program led to significant reductions in depression and distress symptoms. With its potential to be delivered in a scalable, cost-efficient manner, iCBT is a promising strategy to enhance access to effective care. © 2016 Wiley Periodicals, Inc.

  20. Internet-based cognitive behavior therapy for major depressive disorder: A randomized controlled trial

    PubMed Central

    Rosso, Isabelle M.; Killgore, William D.S.; Olson, Elizabeth A.; Webb, Christian A.; Fukunaga, Rena; Auerbach, Randy P.; Gogel, Hannah; Buchholz, Jennifer L.; Rauch, Scott L.

    2017-01-01

    Background Prior research has shown that the Sadness Program, a technician-assisted Internet-based cognitive behavioral therapy (iCBT) intervention developed in Australia, is effective for treating major depressive disorder (MDD). The current study aimed to expand this work by adapting the protocol for an American population and testing the Sadness Program with an attention control group. Methods In this parallel-group, randomized controlled trial, adult MDD participants (18–45 years) were randomized to a 10-week period of iCBT (n = 37) or monitored attention control (MAC; n = 40). Participants in the iCBT group completed six online therapy lessons, which included access to content summaries and homework assignments. During the 10-week trial, iCBT and MAC participants logged into the web-based system six times to complete self-report symptom scales, and a nonclinician technician contacted participants weekly to provide encouragement and support. The primary outcome was the Hamilton Rating Scale for Depression (HRSD), and the secondary outcomes were the Patient Health Questionnaire-9 and Kessler-10. Results Intent-to-treat analyses revealed significantly greater reductions in depressive symptoms in iCBT compared with MAC participants, using both the self-report measures and the clinician-rated HRSD (d = −0.80). Importantly, iCBT participants also showed significantly higher rates of clinical response and remission. Exploratory analyses did not support illness severity as a moderator of treatment outcome. Conclusions The Sadness Program led to significant reductions in depression and distress symptoms. With its potential to be delivered in a scalable, cost-efficient manner, iCBT is a promising strategy to enhance access to effective care. PMID:28009467

  1. Dense Cranial Electroacupuncture Stimulation for Major Depressive Disorder—A Single-Blind, Randomized, Controlled Study

    PubMed Central

    Zhang, Zhang-Jin; Ng, Roger; Man, Sui Cheung; Li, Tsui Yin Jade; Wong, Wendy; Tan, Qing-Rong; Wong, Hei Kiu; Chung, Ka-Fai; Wong, Man-Tak; Tsang, Wai-Kiu Alfert; Yip, Ka-chee; Ziea, Eric; Wong, Vivian Taam

    2012-01-01

    Background Previous studies suggest that electroacupuncture possesses therapeutic benefits for depressive disorders. The purpose of this study was to determine whether dense cranial electroacupuncture stimulation (DCEAS) could enhance the antidepressant efficacy in the early phase of selective serotonin reuptake inhibitor (SSRI) treatment of major depressive disorder (MDD). Methods In this single-blind, randomized, controlled study, patients with MDD were randomly assigned to 9-session DCEAS or noninvasive electroacupuncture (n-EA) control procedure in combination with fluoxetine (FLX) for 3 weeks. Clinical outcomes were measured using the 17-item Hamilton Depression Rating Scale (HAMD-17), Clinical Global Impression-severity (CGI-S), and Self-rating Depression Scale (SDS) as well as the response and remission rates. Results Seventy-three patients were randomly assigned to n-EA (n = 35) and DCEAS (n = 38), of whom 34 in n-EA and 36 in DCEAS group were analyzed. DCEAS-treated patients displayed a significantly greater reduction from baseline in HAMD-17 scores at Day 3 through Day 21 and in SDS scores at Day 3 and Day 21 compared to patients receiving n-EA. DCEAS intervention also produced a higher rate of clinically significant response compared to n-EA procedure (19.4% (7/36) vs. 8.8% (3/34)). The incidence of adverse events was similar in the two groups. Conclusions DCEAS is a safe and effective intervention that augments the antidepressant efficacy. It can be considered as an additional therapy in the early phase of SSRI treatment of depressed patients. Trial Registration Controlled-Trials.com ISRCTN88008690 PMID:22238631

  2. A randomized trial of aerobic exercise on cognitive control in major depression.

    PubMed

    Olson, Ryan L; Brush, Christopher J; Ehmann, Peter J; Alderman, Brandon L

    2017-06-01

    The aim of this study was to examine the effects of an 8-week moderate-intensity aerobic exercise training intervention on cognitive control in individuals with major depressive disorder (MDD). Participants with a current diagnosis of MDD (n=30; 21.1±2.0years) were stratified by depressive symptoms and randomized to an 8-week intervention of aerobic exercise (AE) or placebo exercise (PE). AE consisted of three sessions/week of moderate-intensity exercise training while PE consisted of three sessions/week of light-intensity stretching. Cognitive control was assessed pre- and post-treatment using behavioral performance (i.e., reaction time and accuracy) and event-related potentials (i.e., N2 amplitude). Depressive symptoms and rumination were also assessed before and after the intervention. Compared with PE, the AE treatment arm was associated with an increase in N2 amplitude to incongruent flanker task trials, reflecting an increase in cognitive control processes. Symptoms of depression also decreased after AE although the treatments did not differ in their effects on rumination. Exploratory mediation analysis indicated that changes in N2 amplitude did not mediate pre-to-post treatment reductions in depressive symptoms. An 8-week moderate-intensity AE program is associated with improved neural indices of conflict monitoring and reduced depressive symptoms among individuals with MDD. Future research examining the influence of exercise in combination with behavioral and pharmacological treatments for neurocognitive function in MDD is warranted. Copyright © 2017 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.

  3. Plasma ANP and BNP during exercise in patients with major depressive disorder and in healthy controls.

    PubMed

    Wisén, Anita G M; Ekberg, Kristina; Wohlfart, Björn; Ekman, Rolf; Westrin, Asa

    2011-03-01

    Increased levels of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) have been shown to reduce the hormones in the HPA axis. In this study we addressed the question whether patients with unmedicated major depressive disorder (MDD) might have altered baseline levels of these natriuretic peptides and an altered response to acute exercise. An incremental exercise test was performed in 18 patients with MDD and in 18 healthy controls. Plasma concentrations of ANP and BNP were determined at rest, during the exercise test and 30 min post exercise using immunoradiometric assays. During the exercise test the concentrations of ANP and BNP increased significantly in both groups. The MDD group showed significantly lower levels of ANP than the controls at rest, at maximal work rate and post exercise and of BNP at rest and at maximal work rate. The dynamic changes of both ANP and BNP, respectively, from baseline to maximal work rate were significantly lower in the MDD group. A slightly lower (non-significant) maximal work rate was observed in the MDD group compared with the controls. Group sizes are relatively limited. Lower concentrations of ANP and BNP during rest and exercise were observed in the MDD patients together with a decreased dynamic response to maximal exercise. Hypothetically, the reduced ANP and BNP concentration contributes to the high hormone levels in the HPA system seen in depressive disorders. Of interest for future research is whether physical training might increase the levels of ANP and BNP and thereby diminish depressive symptoms. Copyright © 2010 Elsevier B.V. All rights reserved.

  4. Relapse Prevention in Major Depressive Disorder: Mindfulness-Based Cognitive Therapy Versus an Active Control Condition

    PubMed Central

    Shallcross, Amanda J.; Gross, James J.; Visvanathan, Pallavi D.; Kumar, Niketa; Palfrey, Amy; Ford, Brett Q.; Dimidjian, Sona; Shirk, Stephen; Holm-Denoma, Jill; Goode, Kari M.; Cox, Erica; Chaplin, William; Mauss, Iris B.

    2015-01-01

    Objective We evaluated the comparative effectiveness of Mindfulness-based cognitive therapy (MBCT) versus an active control condition (ACC) for depression relapse prevention, depressive symptom reduction, and improvement in life satisfaction. Method Ninety-two participants in remission from Major Depressive Disorder with residual depressive symptoms were randomized to either an 8-week MBCT or a validated ACC that is structurally equivalent to MBCT and controls for non-specific effects (e.g., interaction with a facilitator, perceived social support, treatment outcome expectations). Both interventions were delivered according to their published manuals. Results Intention-to-treat analyses indicated no differences between MBCT and ACC in depression relapse rates or time to relapse over a 60-week follow-up. Both groups experienced significant and equal reductions in depressive symptoms and improvements in life satisfaction. A significant quadratic interaction (group x time) indicated that the pattern of depressive symptom reduction differed between groups. The ACC experienced immediate symptom reduction post-intervention and then a gradual increase over the 60-week follow-up. The MBCT group experienced a gradual linear symptom reduction. The pattern for life satisfaction was identical but only marginally significant. Conclusions MBCT did not differ from an ACC on rates of depression relapse, symptom reduction, or life satisfaction, suggesting that MBCT is no more effective for preventing depression relapse and reducing depressive symptoms than the active components of the ACC. Differences in trajectory of depressive symptom improvement suggest that the intervention-specific skills acquired may be associated with differential rates of therapeutic benefit. This study demonstrates the importance of comparing psychotherapeutic interventions to active control conditions. PMID:26371618

  5. Doping control analysis of trimetazidine and characterization of major metabolites using mass spectrometric approaches.

    PubMed

    Sigmund, Gerd; Koch, Anja; Orlovius, Anne-Katrin; Guddat, Sven; Thomas, Andreas; Schänzer, Wilhelm; Thevis, Mario

    2014-01-01

    Since January 2014, the anti-anginal drug trimetazidine [1-(2,3,4-trimethoxybenzyl)-piperazine] has been classified as prohibited substance by the World Anti-Doping Agency (WADA), necessitating specific and robust detection methods in sports drug testing laboratories. In the present study, the implementation of the intact therapeutic agent into two different initial testing procedures based on gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-tandem mass spectrometry (LC-MS/MS) is reported, along with the characterization of urinary metabolites by electrospray ionization-high resolution/high accuracy (tandem) mass spectrometry. For GC-MS analyses, urine samples were subjected to liquid-liquid extraction sample preparation, while LC-MS/MS analyses were conducted by established 'dilute-and-inject' approaches. Both screening methods were validated for trimetazidine concerning specificity, limits of detection (0.5-50 ng/mL), intra-day and inter-day imprecision (<20%), and recovery (41%) in case of the GC-MS-based method. In addition, major metabolites such as the desmethylated trimetazidine and the corresponding sulfoconjugate, oxo-trimetazidine, and trimetazidine-N-oxide as identified in doping control samples were used to complement the LC-MS/MS-based assay, although intact trimetazidine was found at highest abundance of the relevant trimetazidine-related analytes in all tested sports drug testing samples. Retrospective data mining regarding doping control analyses conducted between 1999 and 2013 at the Cologne Doping Control Laboratory concerning trimetazidine revealed a considerable prevalence of the drug particularly in endurance and strength sports accounting for up to 39 findings per year.

  6. Serious gaming technology in major incident triage training: a pragmatic controlled trial.

    PubMed

    Knight, James F; Carley, Simon; Tregunna, Bryan; Jarvis, Steve; Smithies, Richard; de Freitas, Sara; Dunwell, Ian; Mackway-Jones, Kevin

    2010-09-01

    By exploiting video games technology, serious games strive to deliver affordable, accessible and usable interactive virtual worlds, supporting applications in training, education, marketing and design. The aim of the present study was to evaluate the effectiveness of such a serious game in the teaching of major incident triage by comparing it with traditional training methods. Pragmatic controlled trial. During Major Incident Medical Management and Support Courses, 91 learners were randomly distributed into one of two training groups: 44 participants practiced triage sieve protocol using a card-sort exercise, whilst the remaining 47 participants used a serious game. Following the training sessions, each participant undertook an evaluation exercise, whereby they were required to triage eight casualties in a simulated live exercise. Performance was assessed in terms of tagging accuracy (assigning the correct triage tag to the casualty), step accuracy (following correct procedure) and time taken to triage all casualties. Additionally, the usability of both the card-sort exercise and video game were measured using a questionnaire. Tagging accuracy by participants who underwent the serious game training was significantly higher than those who undertook the card-sort exercise [Chi2=13.126, p=0.02]. Step accuracy was also higher in the serious game group but only for the numbers of participants that followed correct procedure when triaging all eight casualties [Chi2=5.45, p=0.0196]. There was no significant difference in time to triage all casualties (card-sort=435+/-74 s vs video game=456+/-62 s, p=0.155). Serious game technologies offer the potential to enhance learning and improve subsequent performance when compared to traditional educational methods. Copyright 2010 Elsevier Ireland Ltd. All rights reserved.

  7. Evidence for a major gene controlling susceptibility to tegumentary leishmaniasis in a recently exposed Bolivian population.

    PubMed Central

    Alcaïs, A; Abel, L; David, C; Torrez, M E; Flandre, P; Dedet, J P

    1997-01-01

    Tegumentary leishmaniasis due to Leishmania braziliensis is a parasitic disease that occurs in two stages after the infected sandfly bite: (1) a primary cutaneous lesion followed by (2) a secondary mucosal involvement generally resulting in severe facial deformities. In order to investigate the genetic and environmental factors involved in the development of the cutaneous lesion, a familial study was performed in a region of Bolivia in which the disease is endemic. Complete selection of 118 nuclear families (703 subjects, with 241 patients), each with at least one cutaneous affected subject, was achieved; 41 families were of native origin, and 77 (herein designated "migrant") recently had settled in the area. For the analysis, the trait under study was the time to onset of the primary cutaneous lesion. The start of the follow-up was birth, for native population, or date of arrival in the endemic area, for migrant population. Segregation analysis was performed by use of a model based on survival analysis methods that allows joint estimation of genetic and environmental effects and accounts for gene x covariate interactions. A significant effect of gender, home-forest distance, and forest-related activity was found. In the 77 migrant families there was evidence for a recessive major gene controlling the onset of the primary cutaneous lesion, with residual familial dependences and age x genotype interaction. Penetrance estimations show that young subjects are genetically more susceptible than older subjects, suggesting that this genetic component could concern mechanisms involved in the development of individual protection during childhood. There was also a significant genetic heterogeneity of the sample according to the native/migrant origin of the families, and no major-gene effect was found in the native subsample. PMID:9382111

  8. Efficacy and safety of deep transcranial magnetic stimulation for major depression: a prospective multicenter randomized controlled trial

    PubMed Central

    Levkovitz, Yechiel; Isserles, Moshe; Padberg, Frank; Lisanby, Sarah H; Bystritsky, Alexander; Xia, Guohua; Tendler, Aron; Daskalakis, Zafiris J; Winston, Jaron L; Dannon, Pinhas; Hafez, Hisham M; Reti, Irving M; Morales, Oscar G; Schlaepfer, Thomas E; Hollander, Eric; Berman, Joshua A; Husain, Mustafa M; Sofer, Uzi; Stein, Ahava; Adler, Shmulik; Deutsch, Lisa; Deutsch, Frederic; Roth, Yiftach; George, Mark S; Zangen, Abraham

    2015-01-01

    Major depressive disorder (MDD) is a prevalent and disabling condition, and many patients do not respond to available treatments. Deep transcranial magnetic stimulation (dTMS) is a new technology allowing non-surgical stimulation of relatively deep brain areas. This is the first double-blind randomized controlled multicenter study evaluating the efficacy and safety of dTMS in MDD. We recruited 212 MDD outpatients, aged 22–68 years, who had either failed one to four antidepressant trials or not tolerated at least two antidepressant treatments during the current episode. They were randomly assigned to monotherapy with active or sham dTMS. Twenty sessions of dTMS (18 Hz over the prefrontal cortex) were applied during 4 weeks acutely, and then biweekly for 12 weeks. Primary and secondary efficacy endpoints were the change in the Hamilton Depression Rating Scale (HDRS-21) score and response/remission rates at week 5, respectively. dTMS induced a 6.39 point improvement in HDRS-21 scores, while a 3.28 point improvement was observed in the sham group (p+0.008), resulting in a 0.76 effect size. Response and remission rates were higher in the dTMS than in the sham group (response: 38.4 vs. 21.4%, p+0.013; remission: 32.6 vs. 14.6%, p+0.005). These differences between active and sham treatment were stable during the 12-week maintenance phase. dTMS was associated with few and minor side effects apart from one seizure in a patient where a protocol violation occurred. These results suggest that dTMS constitutes a novel intervention in MDD, which is efficacious and safe in patients not responding to antidepressant medications, and whose effect remains stable over 3 months of maintenance treatment. PMID:25655160

  9. A novel approach for automatic snow depth estimation using UAV-taken images without ground control points

    NASA Astrophysics Data System (ADS)

    Mizinski, Bartlomiej; Niedzielski, Tomasz

    2017-04-01

    Recent developments in snow depth reconstruction based on remote sensing techniques include the use of photographs of snow-covered terrain taken by unmanned aerial vehicles (UAVs). There are several approaches that utilize visible-light photos (RGB) or near infrared images (NIR). The majority of the methods in question are based on reconstructing the digital surface model (DSM) of the snow-covered area with the use of the Structure-from-Motion (SfM) algorithm and the stereo-vision software. Having reconstructed the above-mentioned DSM it is straightforward to calculate the snow depth map which may be produced as a difference between the DSM of snow-covered terrain and the snow-free DSM, known as the reference surface. In order to use the aforementioned procedure, the high spatial accuracy of the two DSMs must be ensured. Traditionally, this is done using the ground control points (GCPs), either artificial or natural terrain features that are visible on aerial images, the coordinates of which are measured in the field using the Global Navigation Satellite System (GNSS) receiver by qualified personnel. The field measurements may be time-taking (GCPs must be well distributed in the study area, therefore the field experts should travel over long distances) and dangerous (the field experts may be exposed to avalanche risk or cold). Thus, there is a need to elaborate methods that enable the above-mentioned automatic snow depth map production without the use of GCPs. One of such attempts is shown in this paper which aims to present the novel method which is based on real-time processing of snow-covered and snow-free dense point clouds produced by SfM. The two stage georeferencing is proposed. The initial (low accuracy) one assigns true geographic, and subsequently projected, coordinates to the two dense point clouds, while the said initially-registered dense point clouds are matched using the iterative closest point (ICP) algorithm in the final (high accuracy) stage. The

  10. The dynamic control ratio at the equilibrium point (DCRe): introducing relative and absolute reliability scores.

    PubMed

    Alt, Tobias; Knicker, Axel J; Strüder, Heiko K

    2017-04-01

    Analytical methods to assess thigh muscle balance need to provide reliable data to allow meaningful interpretation. However, reproducibility of the dynamic control ratio at the equilibrium point has not been evaluated yet. Therefore, the aim of this study was to compare relative and absolute reliability indices of its angle and moment values with conventional and functional hamstring-quadriceps ratios. Furthermore, effects of familiarisation and angular velocity on reproducibility were analysed. A number of 33 male volunteers participated in 3 identical test sessions. Peak moments (PMs) were determined unilaterally during maximum concentric and eccentric knee flexion (prone) and extension (supine position) at 0.53, 1.57 and 2.62 rad · s(-1). A repeated measure, ANOVA, confirmed systematic bias. Intra-class correlation coefficients and standard errors of measurement indicated relative and absolute reliability. Correlation coefficients were averaged over respective factors and tested for significant differences. All balance scores showed comparable low-to-moderate relative (<0.8-0.9) and good absolute reliability (<10%). Relative reproducibility of dynamic control equilibrium parameters augmented with increasing angular velocity, but not with familiarisation. At 2.62 rad · s(-1), high (moment: 0.906) to moderate (angle: 0.833) relative reliability scores with accordingly high absolute indices (4.9% and 6.4%) became apparent. Thus, the dynamic control equilibrium is an equivalent method for the reliable assessment of thigh muscle balance.

  11. Evaluating the role of point source discharges informs statewide nutrient control policy in Utah.

    PubMed

    Daigger, Glen T; Datta, Tania; Stensel, H David; Whitlock, Drury D; Mackey, John K

    2014-06-01

    An evaluation of costs, rate, and environmental impacts of upgrading publically owned treatment works (POTWs) in the State of Utah to four levels of nutrient control allowed a variety of nutrient control policies to be assessed. Upgrade costs and rate impacts indicated that costs would be within a defined range for many POTWs, especially with design capacities greater than 40,000 m3/day (-10 mgd). However, costs were significantly higher for some POTWs with lower design capacities, and nutrient upgrades to the most stringent levels would not be affordable for these communities, representing about 15 percent of the service population. The resulting equity issues can be addressed through hardship grants program and/or regulations based on a trading scheme. Analysis demonstrated that trading offers advantages, including cost efficiency and flexibility to accommodate further nutrient reductions and population growth, and greater ability to interface with urban and rural nonpoint nutrient control. Currently, the State of Utah is establishing technology-based nutrient limits that can be affordably implemented at all POTWs in phases. Additionally, a multi-faceted approach is being evaluated that will consider prioritized watershed-scale strategies, point and nonpoint sources of pollution, ecological and socioeconomic implications, and stakeholder participation in nutrient reduction programs.

  12. End-point control of a two-link manipulator with a very flexible forearm - Issues and experiments

    NASA Technical Reports Server (NTRS)

    Oakley, Celia M.; Cannon, Robert H., Jr.

    1989-01-01

    For mechanical manipulators, a logical sensor location is at the manipulator end-point where tasks are performed. Unfortunately, when bending flexibility exists between an end-point sensor and a joint actuator, stability and performance are achieved only through sophisticated control design. Some of the issues involved in utilizing end-point sensing for two-link flexible manipulators are addressed. A modeling technique that properly represents the foreshortening of a flexible link undergoing deflections is presented. In order to realize fully the advantages of the assumed-modes modeling method, mode shapes are selected that allow a low-order model to be used effectively for simulation and control purposes. A nonlinear controller, incorporating state feedback and a constant-gain extended Kalman filter driven by end-point measurements, is designed and compared to a conventional proportional-plus-derivative controller that uses collocated sensors. Results from implementing these controllers on the experimental Stanford multilink flexible manipulator are given.

  13. End-point control of a two-link manipulator with a very flexible forearm - Issues and experiments

    NASA Technical Reports Server (NTRS)

    Oakley, Celia M.; Cannon, Robert H., Jr.

    1989-01-01

    For mechanical manipulators, a logical sensor location is at the manipulator end-point where tasks are performed. Unfortunately, when bending flexibility exists between an end-point sensor and a joint actuator, stability and performance are achieved only through sophisticated control design. Some of the issues involved in utilizing end-point sensing for two-link flexible manipulators are addressed. A modeling technique that properly represents the foreshortening of a flexible link undergoing deflections is presented. In order to realize fully the advantages of the assumed-modes modeling method, mode shapes are selected that allow a low-order model to be used effectively for simulation and control purposes. A nonlinear controller, incorporating state feedback and a constant-gain extended Kalman filter driven by end-point measurements, is designed and compared to a conventional proportional-plus-derivative controller that uses collocated sensors. Results from implementing these controllers on the experimental Stanford multilink flexible manipulator are given.

  14. Allosteric Regulation Points Control the Conformational Dynamics of the Molecular Chaperone Hsp90.

    PubMed

    Rehn, Alexandra; Moroni, Elisabetta; Zierer, Bettina K; Tippel, Franziska; Morra, Giulia; John, Christine; Richter, Klaus; Colombo, Giorgio; Buchner, Johannes

    2016-11-06

    Heat shock protein 90 (Hsp90) is an ATP-dependent molecular chaperone responsible for the activation, maturation, and trafficking of several hundred client proteins in the cell. It is well known that (but not understood how) residues far away from Hsp90's nucleotide binding pocket can regulate its ATPase activity, a phenomenon called allosteric regulation. Here, the computational design of allosteric mutations was combined with in vitro and in vivo experiments to unravel nucleotide-responsive hot spots in the regulation of Hsp90. With this approach, we identified both activating and inhibiting regulation points and show that changes in those amino acids affect the conformational dynamics and ATPase activity of Hsp90 in vitro. Our observations that activating mutations loosen and inhibiting mutations rigidify the protein explain for the first time how Hsp90 changes in response to allosteric mutations. Additionally, mutations of these allosteric regulation points can be controlled by the interplay with Hsp90 co-chaperones, thus providing cells with an efficient mechanism of modifying Hsp90's intrinsic properties via different layers of regulation. Altogether, our results show that a framework for transmitting conformational information exists in the Hsp90 structure. Copyright © 2016 Elsevier Ltd. All rights reserved.

  15. Control Point Analysis comparison for 3 different treatment planning and delivery complexity levels using a commercial 3-dimensional diode array

    SciTech Connect

    Abdellatif, Ady; Gaede, Stewart

    2014-07-01

    To investigate the use of “Control Point Analysis” (Sun Nuclear Corporation, Melbourne, FL) to analyze and compare delivered volumetric-modulated arc therapy (VMAT) plans for 3 different treatment planning complexity levels. A total of 30 patients were chosen and fully anonymized for the purpose of this study. Overall, 10 lung stereotactic body radiotherapy (SBRT), 10 head-and-neck (H and N), and 10 prostate VMAT plans were generated on Pinnacle{sup 3} and delivered on a Varian linear accelerator (LINAC). The delivered dose was measured using ArcCHECK (Sun Nuclear Corporation, Melbourne, FL). Each plan was analyzed using “Sun Nuclear Corporation (SNC) Patient 6” and “Control Point Analysis.” Gamma passing percentage was used to assess the differences between the measured and planned dose distributions and to assess the role of various control point binning combinations. Of the different sites considered, the prostate cases reported the highest gamma passing percentages calculated with “SNC Patient 6” (97.5% to 99.2% for the 3%, 3 mm) and “Control Point Analysis” (95.4% to 98.3% for the 3%, 3 mm). The mean percentage of passing control point sectors for the prostate cases increased from 51.8 ± 7.8% for individual control points to 70.6 ± 10.5% for 5 control points binned together to 87.8 ± 11.0% for 10 control points binned together (2%, 2-mm passing criteria). Overall, there was an increasing trend in the percentage of sectors passing gamma analysis with an increase in the number of control points binned together in a sector for both the gamma passing criteria (2%, 2 mm and 3%, 3 mm). Although many plans passed the clinical quality assurance criteria, plans involving the delivery of high Monitor Unit (MU)/control point (SBRT) and plans involving high degree of modulation (H and N) showed less delivery accuracy per control point compared with plans with low MU/control point and low degree of modulation (prostate)

  16. [Major Ionic Features and Their Controlling Factors in the Upper-Middle Reaches of Wujiang River].

    PubMed

    Huang, Qi-bo; Qin, Xiao-qun; Liu, Peng-yu; Lan, Fu-ning; Zhang, Lian-kai; Su, Chun-tian

    2016-05-15

    The Wujing River, the largest river in Guizhou Province, is one of the most important water resources for social and economical development. Recently, with the fast population proliferation and rapid economic growth, the drainage basin is intensively interfered by anthropogenic activities. The hydrochemistry of surface water was analyzed from the upper-middle reaches of Wujiang River for investigating the hydrochemical characteristics and their main influencing factors. The results showed that the major cations of the four rivers were Ca²⁺ and Mg²⁺, accounting for more than 70%, and the main anions were HCO₃⁻ and SO₄²⁻, occupying more than 85%. The hydrochemical characteristics in the four rivers were found to be of HCO₃-Ca type, and mainly determined by the carbonate rock dissolution, while only a small proportion of them were of HCO₃ · SO₄-Ca type, reflecting the influence of SO₄²⁻ from anthropogenic activities. Compared to hydrochemical data in 1999, there was an obvious increase in cations and anions concentrations, majorly in NO₃⁻, SO2- ion concentrations, which were significantly affected by human activities. The Na⁺, K⁺ , Cl⁻ in the river mainly came from atmospheric precipitation, and Ca²⁺, HCO₃⁻, Mg²⁺, mainly came from carbonate rocks dissolution, while NO₃⁻ and SO₄²⁻ mainly came from human activities. According to principal component analysis and correlation analysis, hydrochemical composition of Liuchong River was affected by human activity, and that in the upstream of Sancha River was controlled by atmospheric precipitation and the dissolution of carbonate rocks, that to the downstream was enhanced by human activities. The main ion of Maotiao River was controlled by atmospheric precipitation and carbonate rocks dissolution, and also affected by human activity. The Nanming River, the Qingshui river's tributary, was mainly affected by human activity, while the middle and lower reaches of Qingshui

  17. [L-THIA-based management design for controlling urban non-point source pollution].

    PubMed

    Guo, Qing-Hai; Yang, Liu; Ke-Ming, Ma

    2007-11-01

    L-THIA Model was used to simulate the amounts of NPS pollutants in 2 catchments of Sanjiao watershed (Sj1, Sj2) in Hanyang district, and the total simulated amount of NPS loads in Sj1 and Sj2 were 1.82 x 10(4) kg, 1.38 x 10(5) kg, respectively. Based on the theory of resource-sink" and interaction of pattern with process, a series of BMPs, including green roof, grassland, porous pavement, infiltration trench, vegetative filter strip and wet pond, were optimized, and effects of BMPs were simulated along the surface runoff pathway. The results show that total pollutants outputs entering Sj1 and Sj2 account for 14.65% and 6.57%, respectively. Combining L-THIA model and BMPs in series is a proper measure for non-point source pollution control and urban development planning at watershed or region scale.

  18. C-BORD project: "Effective container inspection at BORDer control points"

    NASA Astrophysics Data System (ADS)

    Etilé, Asénath; Roig, Olivier; Bauge, Eric; Gaudefroy, Laurent; Méot, Vincent

    2017-09-01

    In the framework of the C-BORD project of the H2020 programme to provide a safety chain for container inspection at border control points, CEA-DAM is involved to develop an identification method of Special Nuclear Material. Using active interrogation the main purpose is to specifically discriminate fissile actinides from fertile ones through the detection of γ-rays emitted by very short-lived isomers. We present here the interdependance of such a project with nuclear data. We first introduce the SNM identification method. Then, will be detailed the needs in nuclear data and first yields of specific short-lived isomers of 252Cf spontaneous fission. Perspectives and conclusions will end the article.

  19. Mesoscopic capacitor and zero-point energy: Poisson's distribution for virtual charges, pressure, and decoherence control

    NASA Astrophysics Data System (ADS)

    Flores, J. C.

    2014-08-01

    Mesoscopic capacitor theory, which includes intrinsic inductive effects from quantum tunneling, is applied to conducting spherical shells. The zero-point pressure and the number of virtual charged pairs are determined assuming a Poisson distribution. They are completely defined by a dimensionless mesoscopic parameter (χc) measuring the average number of virtual pairs per solid angle and carrying mesoscopic information. Fluctuations remain finite and well defined. Connections with usual quantum-field-theory limit enables us to evaluate χc 1.007110. Equivalently, for a mesoscopic parallel-plate capacitor, the shot noise distribution becomes operative with χc 0.94705 as well being related to the density of virtual pairs. Temperature decoherence and capacitor control are discussed by considering typical values of quantum dot devices and Coulomb blockade theory.

  20. Thermoplastic fusion bonding using a pressure-assisted boiling point control system.

    PubMed

    Park, Taehyun; Song, In-Hyouk; Park, Daniel S; You, Byoung Hee; Murphy, Michael C

    2012-08-21

    A novel thermoplastic fusion bonding method using a pressure-assisted boiling point (PABP) control system was developed to apply precise temperatures and pressures during bonding. Hot embossed polymethyl methacrylate (PMMA) components containing microchannels were sealed using the PABP system. Very low aspect ratio structures (AR = 1/100, 10 μm in depth and 1000 μm in width) were successfully sealed without collapse or deformation. The integrity and strength of the bonds on the sealed PMMA devices were evaluated using leakage and rupture tests; no leaks were detected and failure during the rupture tests occurred at pressures greater than 496 kPa. The PABP system was used to seal 3D shaped flexible PMMA devices successfully.