Explaining the increase in coronary heart disease mortality in Syria between 1996 and 2006.

PubMed

Rastam, Samer; Al Ali, Radwan; Maziak, Wasim; Mzayek, Fawaz; Fouad, Fouad M; O'Flaherty, Martin; Capewell, Simon

2012-09-09

Despite advances made in treating coronary heart disease (CHD), mortality due to CHD in Syria has been increasing for the past two decades. This study aims to assess CHD mortality trends in Syria between 1996 and 2006 and to investigate the main factors associated with them. The IMPACT model was used to analyze CHD mortality trends in Syria based on numbers of CHD patients, utilization of specific treatments, trends in major cardiovascular risk factors in apparently healthy persons and CHD patients. Data sources for the IMPACT model included official statistics, published and unpublished surveys, data from neighboring countries, expert opinions, and randomized trials and meta-analyses. Between 1996 and 2006, CHD mortality rate in Syria increased by 64%, which translates into 6370 excess CHD deaths in 2006 as compared to the number expected had the 1996 baseline rate held constant. Using the IMPACT model, it was estimated that increases in cardiovascular risk factors could explain approximately 5140 (81%) of the CHD deaths, while some 2145 deaths were prevented or postponed by medical and surgical treatments for CHD. Most of the recent increase in CHD mortality in Syria is attributable to increases in major cardiovascular risk factors. Treatments for CHD were able to prevent about a quarter of excess CHD deaths, despite suboptimal implementation. These findings stress the importance of population-based primary prevention strategies targeting major risk factors for CHD, as well as policies aimed at improving access and adherence to modern treatments of CHD.

Food poisoning--a major threat to airline operations.

PubMed

Burslem, C D; Kelly, M J; Preston, F S

1990-01-01

In the spring of 1984, British Airways was involved in a major food poisoning outbreak which affected nearly 1000 passengers, aircrew and ground personnel. The operational impact was worldwide and could have resulted in the cessation of the airline's day-to-day operations. The investigation paralleled a major aircraft disaster in the number of national and international agencies involved and in the variety of disciplines engaged. Although the causative organism was rapidly identified (salmonella), and its introduction into the food chain proved to be a key factor, the scale of the outbreak was the result of an interaction of other factors. As with a major aircraft accident, none of the factors alone would have caused the near disaster that occurred.

[Independence in Plastic Surgery - Benefit or Barrier? Analysis of the Publication Performance in Academic Plastic Surgery Depending on Varying Organisational Structures].

PubMed

Schubert, C D; Leitsch, S; Haertnagl, F; Haas, E M; Giunta, R E

2015-08-01

Despite its recognition as an independent specialty, at German university hospitals the field of plastic surgery is still underrepresented in terms of independent departments with a dedicated research focus. The aim of this study was to analyse the publication performance within the German academic plastic surgery environment and to compare independent departments and dependent, subordinate organisational structures regarding their publication performance. Organisational structures and number of attending doctors in German university hospitals were examined via a website analysis. A pubmed analysis was applied to assess the publication performance (number of publications, cumulative impact factor, impact factor/publication, number of publications/MD, number of publications/unit) between 2009 and 2013. In a journal analysis the distribution of the cumulative impact factor and number of publications in different journals as well as the development of the impact factor in the top journals were analysed. Out of all 35 university hospitals there exist 12 independent departments for plastic surgery and 8 subordinate organisational structures. In 15 university hospitals there were no designated plastic surgery units. The number of attending doctors differed considerably between independent departments (3.6 attending doctors/unit) and subordinate organisational structures (1.1 attending doctors/unit). The majority of publications (89.0%) and of the cumulative impact factor (91.2%) as well as most of the publications/MD (54 publications/year) and publications/unit (61 publications/year) were created within the independent departments. Only in departments top publications with an impact factor > 5 were published. In general a negative trend regarding the number of publications (- 13.4%) and cumulative impact factor (- 28.9%) was observed. 58.4% of all publications were distributed over the top 10 journals. Within the latter the majority of articles were published in English journals (60% of publications, 79.9% of the cumulative impact factor). The average impact factor of the top 10 journals increased by 13.5% from 2009 to 2013. In contrast to subordinate and dependent organisational structures, independent departments of plastic surgery are the key performers within German academic plastic surgery which, however, suffers from a general declining publication performance. Hence, the type of organisational structure has a crucial influence on the research performance. © Georg Thieme Verlag KG Stuttgart · New York.

Fate of abstracts presented at the 2002 IFCC meeting.

PubMed

Uysal, Sezer; Tuglu, Birsen; Ozalp, Ylmaz; Onvural, Banu

2008-01-01

Poster presentations at major meetings serve to rapidly present and share study results with the scientific community. On the other hand, full-text publication of abstracts in peer-reviewed journals provides dissemination of knowledge. The purpose of this study was to evaluate the publication rate of abstracts presented at the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) Meeting, to assess the factors influencing publication and determine the impact factor of these journals. All poster abstracts presented at the 2002 IFCC Meeting were included in the study. A Medline search was performed to identify a matching journal article. Topics, country of origin, study type, study center and publication year were tabulated. Journals and impact factors of publication were noted. Out of 900 presented abstracts, 125 (13.9%) were published as full-text articles. Publication rates according to topics of the meeting, country of origin and university affiliation demonstrated significant differences. Abstracts from multi-centered studies had higher publication rates, and the journals they were published in had higher impact factors than single center studies. The median impact factor of the journals was 2.093. According to regression analysis, the major predictors for publication were interventional research and university affiliation (odds ratios 2.916 and 1.782, respectively; p < 0.05). The publication rate for abstracts of this clinical chemistry meeting was lower than rates from other fields of medicine. Factors leading to failure require elucidation. Encouraging authors to submit their presentations for full-text publication might improve the rate of publication.

Columbia River System Operation Review : Final Environmental Impact Statement, Appendix J: Recreation.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Columbia River System Operation Review

1995-11-01

This Appendix J of the Final Environmental Impact Statement for the Columbia River System discusses impacts on the recreational activities in the region. Major sections include the following: scope and processes; recreation in the Columbia River Basin today - by type, location, participation, user characteristics, factors which affect usage, and managing agencies; recreation analysis procedures and methodology; and alternatives and their impacts.

Author Impact Factor: tracking the dynamics of individual scientific impact

NASA Astrophysics Data System (ADS)

Pan, Raj Kumar; Fortunato, Santo

2014-05-01

The impact factor (IF) of scientific journals has acquired a major role in the evaluations of the output of scholars, departments and whole institutions. Typically papers appearing in journals with large values of the IF receive a high weight in such evaluations. However, at the end of the day one is interested in assessing the impact of individuals, rather than papers. Here we introduce Author Impact Factor (AIF), which is the extension of the IF to authors. The AIF of an author A in year t is the average number of citations given by papers published in year t to papers published by A in a period of Δt years before year t. Due to its intrinsic dynamic character, AIF is capable to capture trends and variations of the impact of the scientific output of scholars in time, unlike the h-index, which is a growing measure taking into account the whole career path.

Workplace practices with mental health implications impacting on recruitment and retention of overseas nurses in the context of nursing shortages.

PubMed

Omeri, Akram

2006-01-01

In response to nursing workforce shortages, health agencies in Australia and elsewhere have sought to meet the demand for nursing services by recruiting nurses internationally. While there is a major focus on recruitment, little attention is given to factors that could enhance retention of overseas qualified nurses. There are a host of factors reported in the literature that impact upon retention of overseas nurses in the workforce, including: impact of re-settlement experiences in the new country; discriminatory practices in accessing employment and negative experiences in the work place. For the benefit of long term retention of overseas nurse graduates in the workforce in Australia and globally, these experiences are major issues needing urgent attention. This discussion paper reviews the literature to explore the impact of aggression and discriminatory practices in nursing as evidence for nurses leaving the profession, and discusses the mental health implications and consequences of such practices relating to overseas nurse graduates.

Sex differences in the pathways to major depression: a study of opposite-sex twin pairs.

PubMed

Kendler, Kenneth S; Gardner, Charles O

2014-04-01

The authors sought to clarify the nature of sex differences in the etiologic pathways to major depression. Retrospective and prospective assessments of 20 developmentally organized risk factors and the occurrence of past-year major depression were conducted at two waves of personal interviews at least 12 months apart in 1,057 opposite-sex dizygotic twin pairs from a population-based register. Analyses were conducted by structural modeling, examining within-pair differences. Sixty percent of all paths in the best-fit model exhibited sex differences. Eleven of the 20 risk factors differed across sexes in their impact on liability to major depression. Five had a greater impact in women: parental warmth, neuroticism, divorce, social support, and marital satisfaction. Six had a greater impact in men: childhood sexual abuse, conduct disorder, drug abuse, prior history of major depression, and distal and dependent proximal stressful life events. The life event categories responsible for the stronger effect in males were financial, occupational, and legal in nature. In a co-twin control design, which matches sisters and brothers on genetic and familial-environmental background, personality and failures in interpersonal relationships played a stronger etiologic role in major depression for women than for men. Externalizing psychopathology, prior depression, and specific "instrumental" classes of acute stressors were more important in the etiologic pathway to major depression for men. The results are consistent with previously proposed typologies of major depression that suggest two subtypes that differ in prevalence in women (deficiencies in caring relationships and interpersonal loss) and men (failures to achieve expected goals, with lowered self-worth).

The Influence of Cytochrome P450 Pharmacogenetics on Disposition of Common Antidepressant and Antipsychotic Medications

PubMed Central

van der Weide, Jan; Hinrichs, John WJ

2006-01-01

Since the identification of all the major drug-metabolising cytochrome P450 (CYP) enzymes and their major gene variants, pharmacogenetics has had a major impact on psychotherapeutic drug therapy. CYP enzymes are responsible for the metabolism of most clinically used drugs. Individual variability in CYP activity is an important reason for drug therapy failure. Variability in CYP activity may be caused by various factors, including endogenous factors such as age, gender and morbidity as well as exogenous factors such as co-medication, food components and smoking habit. However, polymorphisms, present in most CYP genes, are responsible for a substantial part of this variability. Although CYP genotyping has been shown to predict the majority of aberrant phenotypes, it is currently rarely performed in clinical practice. PMID:16886044

Influential Factors for Mobile Learning Acceptance among Chinese Users

ERIC Educational Resources Information Center

Hao, Shuang; Dennen, Vanessa P.; Mei, Li

2017-01-01

This study examines the factors that influence mobile learning adoption among Chinese university students. China's higher education market is large and mobile device ownership is considered a status symbol. Combined, these two factors suggest mobile learning could have a big impact in China. From the literature, we identified three major areas…

Environmetric data interpretation to assess the water quality of Maritsa River catchment.

PubMed

Papazova, Petia; Simeonova, Pavlina

2013-01-01

Maritsa River is one of the largest rivers flowing on Bulgarian territory. The quality of its waters is of substantial importance for irrigation, industrial, recreation and domestic use. Besides, part of the river is flowing on Turkish territory and the control and management of the Maritsa catchment is of mutual interst for the neighboring countires. Thus, performing interpretation and modeling of the river water quality is a major environmetric problem. Two multivariate statstical methods (Cluster analysis/CA/and Principal components analysis/PCA/) were applied for model assessment of the water quality of Maritsa River on Bulgarian territory. The study used long-term monitoring data from 21 sampling sites characterized by 8 surface water quality indicators. The application of CA to the indicators results in 3 significant clusters showing the impact of biological, anthropogenic and eutrophication sources. For further assessment of the monitoring data, PCA was implemented, which identified, again,three latent factors confirming, in principle, the clustering output. The latent factors were conditionally named "biologic", "anthropogenic" and "eutrophication" source. Their identification coinside correctly to the location of real pollution sources along the Maritsa River catchment. The linkage of the sampling sites along the river flow by CA identified four special patterns separated by specific tracers levels: biological and anthropogenic major impact for pattern 1, euthrophication major impact for pattern 2, background levels for pattern 3 and eutrophication and agricultural major impact for pattern 4. The apportionment models of the pollution determined the contribution of each one of identified pollution factors to the total concentration of each one of the water quality parameters. Thus, a better risk management of the surface water quality is achieved both on local and national level.

IMPACT OF OBESITY ON DEVELOPMENT AND PROGRESSION OF MAMMARY TUMORS IN PRECLINICAL MODELS OF BREAST CANCER

PubMed Central

Cleary, Margot P.

2013-01-01

Overweight and/or obesity are known risk factors for postmenopausal breast cancer. More recently increased body weight has also been associated with poor prognosis for both pre- and postmenopausal breast cancer. This relationship has primarily been identified through epidemiological studies. Additional information from in vitro studies has also been produced in attempts to delineate mechanisms of action for the association of obesity and body weight and breast cancer. This approach has identified potential growth factors such as insulin, leptin, estrogen and IGF-I which are reported to be modulated by body weight changes. However, in vitro studies are limited in scope and frequently use non-physiological concentrations of growth factors, while long follow-up is needed for human studies. Preclinical animal models provide an intermediary approach to investigate the impact of body weight and potential growth factors on mammary/breast tumor development and progression. Here results of a number of studies addressing this issue are presented. In the majority of the studies either genetically-obese or diet-induced obese rodent models have been used to investigate spontaneous, transgenic and carcinogen-induced mammary tumor development. To study tumor progression the major focus has been allograft studies in mice with either genetic or dietary-induced obesity. In general, obesity has been demonstrated to shorten mammary tumor latency and to impact tumor pathology. However, in rodents with defects in leptin and other growth factors the impact of obesity is not as straightforward. Future studies using more physiologically relevant obesity models and clearly distinguishing diet composition from body weight effects will be important in continuing to understand the factors associated with body weight’s impact on the mammary/breast cancer development and progression. PMID:24122258

Explaining the increase in coronary heart disease mortality in Syria between 1996 and 2006

PubMed Central

2012-01-01

Background Despite advances made in treating coronary heart disease (CHD), mortality due to CHD in Syria has been increasing for the past two decades. This study aims to assess CHD mortality trends in Syria between 1996 and 2006 and to investigate the main factors associated with them. Methods The IMPACT model was used to analyze CHD mortality trends in Syria based on numbers of CHD patients, utilization of specific treatments, trends in major cardiovascular risk factors in apparently healthy persons and CHD patients. Data sources for the IMPACT model included official statistics, published and unpublished surveys, data from neighboring countries, expert opinions, and randomized trials and meta-analyses. Results Between 1996 and 2006, CHD mortality rate in Syria increased by 64%, which translates into 6370 excess CHD deaths in 2006 as compared to the number expected had the 1996 baseline rate held constant. Using the IMPACT model, it was estimated that increases in cardiovascular risk factors could explain approximately 5140 (81%) of the CHD deaths, while some 2145 deaths were prevented or postponed by medical and surgical treatments for CHD. Conclusion Most of the recent increase in CHD mortality in Syria is attributable to increases in major cardiovascular risk factors. Treatments for CHD were able to prevent about a quarter of excess CHD deaths, despite suboptimal implementation. These findings stress the importance of population-based primary prevention strategies targeting major risk factors for CHD, as well as policies aimed at improving access and adherence to modern treatments of CHD. PMID:22958443

Impact of propulsion system R and D on electric vehicle performance and cost

NASA Technical Reports Server (NTRS)

Schwartz, H. J.; Gordan, A. L.

1980-01-01

The efficiency, weight, and manufacturing cost of the propulsion subsystem (motor, motor controller, transmission, and differential, but excluding the battery) are major factors in the purchase price and cost of ownership of a traffic-compatible electric vehicle. The relative impact of each was studied, and the conclusions reached are that propulsion system technology advances can result in a major reduction of the sticker price of an electric vehicle and a smaller, but significant, reduction in overall cost of ownership.

32 CFR 989.21 - Record of decision (ROD).

Code of Federal Regulations, 2014 CFR

2014-07-01

... ENVIRONMENTAL IMPACT ANALYSIS PROCESS (EIAP) § 989.21 Record of decision (ROD). (a) The proponent and the EPF... all the major factors the agency weighed in making its decision, including essential considerations of... avoid, minimize, or mitigate environmental impacts and, if not, explain why not. [64 FR 38129, July 15...

32 CFR 989.21 - Record of decision (ROD).

Code of Federal Regulations, 2012 CFR

2012-07-01

... ENVIRONMENTAL IMPACT ANALYSIS PROCESS (EIAP) § 989.21 Record of decision (ROD). (a) The proponent and the EPF... all the major factors the agency weighed in making its decision, including essential considerations of... avoid, minimize, or mitigate environmental impacts and, if not, explain why not. [64 FR 38129, July 15...

32 CFR 989.21 - Record of decision (ROD).

Code of Federal Regulations, 2013 CFR

2013-07-01

... ENVIRONMENTAL IMPACT ANALYSIS PROCESS (EIAP) § 989.21 Record of decision (ROD). (a) The proponent and the EPF... all the major factors the agency weighed in making its decision, including essential considerations of... avoid, minimize, or mitigate environmental impacts and, if not, explain why not. [64 FR 38129, July 15...

Higher Education Research Digest

ERIC Educational Resources Information Center

ACT, Inc., 2017

2017-01-01

This new ACT publication is an annual report offering meaningful research insights for some of the most pressing questions impacting admissions and enrollment practice. In the first release of this report, ACT research sheds light on the following topics: (1) the practice of super-scoring; (2) STEM major choice; (3) factors impacting retention and…

How come scientists uncritically adopt and embody Thomson's bibliographic impact factor?

PubMed

Porta, Miquel; Alvarez-Dardet, Carlos

2008-05-01

The bibliographic impact factor (BIF) of Thomson Scientific is sometimes not a valid scientometric indicator for a number of reasons. One major reason is the strong influence of the number of "source items" or "articles" for each journal that the company chooses each year as BIF's denominator. The irresistible fascination with (and picturesque uses of) a construct as scientifically weak as BIF are simple reminders that scientists are embedded in and embody culture.

Temporal Changes of Protein Composition in Breast Milk of Chinese Urban Mothers and Impact of Caesarean Section Delivery

PubMed Central

Affolter, Michael; Garcia-Rodenas, Clara L.; Vinyes-Pares, Gerard; Jenni, Rosemarie; Roggero, Iris; Avanti-Nigro, Ornella; de Castro, Carlos Antonio; Zhao, Ai; Zhang, Yumei; Wang, Peiyu; Thakkar, Sagar K.; Favre, Laurent

2016-01-01

Human breast milk (BM) protein composition may be impacted by lactation stage or factors related to geographical location. The present study aimed at assessing the temporal changes of BM major proteins over lactation stages and the impact of mode of delivery on immune factors, in a large cohort of urban mothers in China. 450 BM samples, collected in three Chinese cities, covering 8 months of lactation were analyzed for α-lactalbumin, lactoferrin, serum albumin, total caseins, immunoglobulins (IgA, IgM and IgG) and transforming growth factor (TGF) β1 and β2 content by microfluidic chip- or ELISA-based quantitative methods. Concentrations and changes over lactation were aligned with previous reports. α-lactalbumin, lactoferrin, IgA, IgM and TGF-β1 contents followed similar variations characterized by highest concentrations in early lactation that rapidly decreased before remaining stable up to end of lactation. TGF-β2 content displayed same early dynamics before increasing again. Total caseins followed a different pattern, showing initial increase before decreasing back to starting values. Serum albumin and IgG levels appeared stable throughout lactation. In conclusion, BM content in major proteins of urban mothers in China was comparable with previous studies carried out in other parts of the world and C-section delivery had only very limited impact on BM immune factors. PMID:27548208

Relationships in the Flipped Classroom

ERIC Educational Resources Information Center

McCollum, Brett M.; Fleming, Cassidy L.; Plotnikoff, Kara M.; Skagen, Darlene N.

2017-01-01

This study examines the effectiveness of flipped classrooms in chemistry, and identifies relationships as a major factor impacting the success of flipped instruction methods. Examination of student interview data reveals factors that affect the development of peer-peer, peer-peer leader, and peer-expert relationships in firstyear general chemistry…

The global impact of noncommunicable diseases: estimates and projections.

PubMed

Manton, K G

1988-01-01

With the aging of populations in developing countries there is both a demographic and an epidemiological transition which affects the impact of chronic degenerative diseases on the health status of the populations. Demographic transition takes place in countries where there are effective programmes of disease control which allow for survival during the early years of childhood and adolescence. This results in an increase in life expectancy which places larger proportions of the population in the age range (60 years and older) in which chronic degenerative diseases become the major determinants of health status. Epidemiological transition in diseases may also be brought about by shifts in social and economic patterns which favour detrimental changes in risk factors for the chronic degenerative diseases. Such changes may include health-related behaviour which augments dietary consumption of fats and alcohol, increases obesity, increases smoking and decreases physical activity. Such changes in risk-factor levels increase the prevalence of chronic degenerative diseases which manifest themselves at later ages, and for which early preventive actions could be cost-effective. In order to illustrate the impact of both demographic and risk-factor effects, analyses are made of the impact of increases in life expectancy on cause-specific mortality in both developing and developed countries. It is shown that there is great similarity in the effect of major noncommunicable diseases on the life expectancy of adults in both developed and developing countries. The major differences are seen to be in the proportions of deaths expected from such diseases as cancer, diabetes, heart disease, stroke and cirrhosis; but not in the distribution of age at death which is the better measure of disease impact. Demographic analyses, computing indirect estimates of mortality, also demonstrate that there are currently more chronic disease deaths in developing than developed countries and that as expectation of life increases in developing countries the global chronic disease burden will be greatly concentrated in the developing countries. Analyses of risk-factor reduction by feasible intervention strategies, e.g. smoking cessation campaigns, treatment of high blood pressure, using relationships between risk factors and diseases established in longitudinal studies carried out in developed countries, point out that the effect of risk-factor control in long-living populations can be hidden by the dependency of risk factors and various related causes of death, e.g. smoking has an impact on lung cancer, ischaemic heart disease and emphysema, but at different ages.(ABSTRACT TRUNCATED AT 400 WORDS)

Factors Caribbean Overseas Students Perceive Influence Their Academic Self-Efficacy

ERIC Educational Resources Information Center

Edwards-Joseph, Arline; Baker, Stanley

2014-01-01

This study investigated factors that influenced the academic self-efficacy of Caribbean overseas students attending universities in the United States, and the themes that emerged from their perceptions of variables impacting their academic self-efficacy. Seven major themes (educational background, faith in God, finances, age and maturity,…

Tool for assessing health and equity impacts of interventions modifying air quality in urban environments.

PubMed

Cartier, Yuri; Benmarhnia, Tarik; Brousselle, Astrid

2015-12-01

Urban outdoor air pollution (AP) is a major public health concern but the mechanisms by which interventions impact health and social inequities are rarely assessed. Health and equity impacts of policies and interventions are questioned, but managers and policy agents in various institutional contexts have very few practical tools to help them better orient interventions in sectors other than the health sector. Our objective was to create such a tool to facilitate the assessment of health impacts of urban outdoor AP interventions by non-public health experts. An iterative process of reviewing the academic literature, brainstorming, and consultation with experts was used to identify the chain of effects of urban outdoor AP and the major modifying factors. To test its applicability, the tool was applied to two interventions, the London Low Emission Zone and the Montréal BIXI public bicycle-sharing program. We identify the chain of effects, six categories of modifying factors: those controlling the source of emissions, the quantity of emissions, concentrations of emitted pollutants, their spatial distribution, personal exposure, and individual vulnerability. Modifiable and non-modifiable factors are also identified. Results are presented in the text but also graphically, as we wanted it to be a practical tool, from pollution sources to emission, exposure, and finally, health effects. The tool represents a practical first step to assessing AP-related interventions for health and equity impacts. Understanding how different factors affect health and equity through air pollution can provide insight to city policymakers pursuing Health in All Policies. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

The financial impact of hospitals on the local economy--2 new factors.

PubMed

Rotarius, Timothy; Liberman, Aaron

2014-01-01

This research effort presents a descriptive analysis of the financial impact that several hospitals have on their local economy. An earlier study published by the authors included 3 distinct, yet overlapping components of financial impact: (1) the hospital system as a major health care provider, (2) the hospital system as a large employer, and (3) the hospital system as an entity whose employees contribute greatly to their local community. This new study added additional financial impact factors: (4) the hospital system as an organization committed to major construction projects in pursuit of its health services mission, and (5) the hospital system as an entity that pays taxes to government agencies. The inextricable relationship of these 5 categories both increases and enhances the impact of the hospital system on the local region. The results of this updated and expanded analysis suggest strongly that the hospital system represents 1 of the primary contributors to the economy of the region. The hospital system adds $3 billion to the $28 billion local economy, which means that the hospital system and its employees are responsible for 10.7% of the total economic prowess of the region.

Can prevention eliminate caries?

PubMed

O'Mullane, D

1995-07-01

There are four main factors involved in the carious process: at-risk tooth structure, plaque flora, fermentable carbohydrates, and time. Based on our knowledge of the carious process, four main preventive strategies have been developed over the years, namely, fluorides, fissure sealing, dietary choice, and plaque control. Fluorides are having a major impact on smooth-surface caries; hence, strategies combining fluorides and fissure sealing are very effective. However, use of fissure sealing is still problematic. Changing dietary practices with a view to reducing dental caries seems to be having little impact on a global scale. Plaque control, as practiced routinely by the majority of people, is not sufficient to result in caries reductions. Deprivation and poverty are strongly associated with high caries levels. Although the preventive strategies currently available are likely to result in lower caries levels for many, for logistical reasons and because of factors associated with deprivation and poverty, caries is likely to remain a major public health problem in most communities for the foreseeable future.

Energy transfer mechanism and probability analysis of submarine pipe laterally impacted by dropped objects

NASA Astrophysics Data System (ADS)

Liang, Jing; Yu, Jian-xing; Yu, Yang; Lam, W.; Zhao, Yi-yu; Duan, Jing-hui

2016-06-01

Energy transfer ratio is the basic-factor affecting the level of pipe damage during the impact between dropped object and submarine pipe. For the purpose of studying energy transfer and damage mechanism of submarine pipe impacted by dropped objects, series of experiments are designed and carried out. The effective yield strength is deduced to make the quasi-static analysis more reliable, and the normal distribution of energy transfer ratio caused by lateral impact on pipes is presented by statistic analysis of experimental results based on the effective yield strength, which provides experimental and theoretical basis for the risk analysis of submarine pipe system impacted by dropped objects. Failure strains of pipe material are confirmed by comparing experimental results with finite element simulation. In addition, impact contact area and impact time are proved to be the major influence factors of energy transfer by sensitivity analysis of the finite element simulation.

Student Input, Student Involvement, and College Environment Factors Impacting the Choice of Academic Major.

ERIC Educational Resources Information Center

Coperthwaite, Corby A.; Knight, William E.

This study investigated the ability of student inputs, student involvements, and college environments to predict seven groups of academic majors. The research was conducted using a sample of college sophomores extracted from High School and Beyond 1982 follow-up cohort, N=43,614 (weighted). Among the findings of the hierarchical discriminant…

A review of major factors influencing plant responses to recreation impacts

NASA Astrophysics Data System (ADS)

Kuss, Fred R.

1986-09-01

This article reviews some of the more important factors found to influence the susceptibility of plants to trampling impacts associated with recreational use of natural areas. A three-way interaction mediates plant responses to impacts: plant x environment x stress level(s). Plant responses vary in part according to the genetic constitution of the plant, life and growth form, the adaptive flexibility of the plant, and anatomical differences inherent to growth habit and morphology. Other factors that influence plant sensitivities to impacts are the habitat environments in which plants grow, since a number of conditions such as moisture excesses or deficiencies, nitrogen or oxygen starvation, late frosts, etc., cause physiological injury and may increase plant sensitivity to impacts. Among the environmental factors that may increase or lessen plant sensitivities to impacts are soil moisture levels, canopy density, elevation, aspect, microclimate, soil drainage, texture, fertility and productivity. Seasonal influences also bear consideration since environmental changes and phonological and physiological events are mediated by time of year. Stresses are caused by both direct and indirect forms of impact and vary according to season of use, frequency and amount of use, and the type of activity. These interactions are further complicated by evidence that inter- and intraspecific competition, antagonism, and commensalism may influence differences in the sensitivity of plant communities to impacts.

[SOME CONSIDERATIONS ABOUT THE INTRINSIC VALUE OF THE IMPACT FACTOR OF SCIENTIFIC JOURNALS].

PubMed

Franco-López, Ángeles; González-Gallego, Javier; Sanz-Valero, Javier; Tuñón, María Jesús; García-De-Lorenzo, Abelardo; Culebras, Jesús M

2015-12-01

The reason of higher number of citations of some articles is discussed. Some considerations about the journals' impact factor, its merits and its pitfalls are also made. Scientific journals' impact factor, popularized by the Institute for Scientific Information, has become an objective parameter for authors' evaluation and also for institutions and other related circumstances. There is no reason for the impact factor's gap between some English journals and those written in other languages. English journals probably benefit of the "Mathew's effect", according to which eminent scientists are more rewarded by similar contributions than others less known. It is paradoxical that most of the major achievements of our age do not appear among the 100 most cited articles. There is no homogeneity among all the articles appearing in each scientific journal: half of the articles are cited ten times more than the other half. However, those articles cited 0 times are credited like the better ones. Each article should be evaluated by its own citations, which would be its impact factor; the authors should be evaluated by their H index. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.

Risk Factors and Levels of Risk for High School Dropouts

ERIC Educational Resources Information Center

Suh, Suhyun; Suh, Jingyo

2007-01-01

The study in this article identifies three major risk categories of high school dropouts and evaluates the impact of possible prevention strategies. As students accumulate these risks, they became more likely to drop out and prevention programs become less effective. Additionally, it was found that factors influencing the decision to drop out vary…

Environmental Barriers Experienced by Urban and Rural Disabled People in South Africa

ERIC Educational Resources Information Center

Maart, S.; Eide, A. H.; Jelsma, J.; Loeb, M. E.; Toni, M. Ka

2007-01-01

Impairments pose a certain degree of difficulty to disabled people, however the impact of the environment is the major cause of disability. Despite the fact that the disabling effect of environmental factors is acknowledged, little research has been done to explore the impact of the environment on varying degrees of disability and different…

The Implementation, Evolution and Impact of New Zealand's National Qualifications Framework

ERIC Educational Resources Information Center

Strathdee, Robert

2011-01-01

This article outlines some of the major factors leading to the introduction of the New Zealand National Qualifications Framework (NQF). It also describes the NQF's design, outlines changes that were introduced following its introduction in 1991, and explores its impact to date. The New Zealand case is interesting, as the agency responsible for the…

The impact of managed care contracts on the admission and registration process.

PubMed

Tilley, B G

1993-04-01

With increasing demand placed on the admission and registration process, hospitals are undergoing dramatic operational changes. These changes are necessary to maintain the vital cash flow of the hospitals. A major factor forcing hospitals to rethink the front line process in the admission and registration area is the impact of managed care.

Work-Life Balance and the Canadian Teaching Profession

ERIC Educational Resources Information Center

Froese-Germain, Bernie

2014-01-01

Over the past few decades Canada has experienced sweeping demographic, social, economic and technological changes. These changes have had, and continue to have, a major impact on the work-life balance of Canadians--that is, on their ability to balance work and personal demands. Some of these factors also impact the work-life balance of the…

Declining national park visitation: An economic analysis

Treesearch

Thomas H. Stevens; Thomas A. More; Marla Markowski-Lindsay

2014-01-01

Visitation to the major nature-based national parks has been declining. This paper specifies an econometric model that estimates the relative impact of consumer incomes, travel costs, entry fees and other factors on per capita attendance from 1993 to 2010. Results suggest that entrance fees have had a statistically significant but small impact on per capita attendance...

Influence of non-dietary factors on the prevalence of abdominal obesity as a major component of the metabolic syndrome among 17-18-year-old youth.

PubMed

Piotrowska, Ewa; Broniecka, Anna; Biernat, Jadwiga; Wyka, Joanna; Bronkowska, Monika

2015-01-01

Youth nutrition and their nutritional status are conditioned by many factors, some of the main ones being: economic, social, climatic, cultural, and psychological factors as well as nutritional knowledge. With the growing problem of overweight and obesity among children and young people, the incidence of the metabolic syndrome is also increasing. The aim of the study was to assess the impact of demographic, sociological and psychological factors on the incidence of obesity among 17-18-year-old adolescents from Wroclaw and vicinity as a major risk factor for the development of the metabolic syndrome. The study was conducted in three upper-secondary schools in Wroclaw, Poland. In the surveyed group (17-18 years old, n = 269) girls accounted for 59.5% and boys constituted 40.5%. Majority of young people were Wroclaw citizens (72.9%). Centile charts elaborated by the Children's Memorial Health Institute were adopted for the evaluation of anthropometric parameters. Evaluation of the impact of non-dietary factors on the manner of nutrition was carried out using own questionnaire. Based on the tests, abdominal obesity was determined among 34.5% of adolescents aged 17 years and among 65.5% of these aged 18 years. Obesity was more common in girls carrying genetic burden of the disease. Youth with the largest waist circumference most often declared to use slimming diets - 6.7%, and the lowest hunger sensation in stress - 3.4%. In addition, 30.5% of the adolescents with the smallest waist circumference and 11.5% with the largest waist circumference declared to be non-smoking. Occasional alcohol consumption was declared by 30.1% of young people with the smallest waist circumference, and 13.4% with the largest waist circumference. Youth with abdominal obesity significantly more likely than those with normal waist circumference applied slimming diets. Significant impact on the formation of abdominal obesity among girls had inherited disease burden.

The Impact of Demographic and Socioeconomic Factors on Major Salivary Gland Cancer Survival.

PubMed

Olarte, Lucia S; Megwalu, Uchechukwu C

2014-06-01

This study aimed to investigate the impact of demographic and socioeconomic factors on survival in patients with major salivary gland malignancies. Population-based study using the Surveillance, Epidemiology, and End Results (SEER) cancer database. The study cohort consisted of 10,735 men and women ages 20 and older who were diagnosed with major salivary gland carcinoma from 1973 to 2009. Kaplan-Meier analysis revealed that the overall and disease-specific survival was higher for women than for men (P < .001). Overall and disease-specific survival decreased with increasing age (P < .001) and differed by race (P < .001) and marital status (P < .001). Patients residing in counties with higher rates of high school completion had higher overall and disease-specific survival (P < .001). Patients residing in counties with higher median household incomes had better overall and disease-specific survival than patients from lower income counties (P < .001). On multivariable analysis, male sex (hazard ratio [HR] = 1.41; 95% confidence interval [CI], 1.32-1.50), increasing age, and single status (HR = 1.36; 95% CI, 1.27-1.44) had poor prognostic impact on overall survival. Male sex (HR = 1.38; 95% CI, 1.27-1.49), increasing age, and single status (HR = 1.29; 95% CI, 1.19-1.39) had poor prognostic impact on disease-specific survival. For patients with salivary gland malignancies, there is a survival benefit for younger patients, female patients, and married patients. This highlights the significance of demographic factors on survival outcomes for patients with salivary gland malignancies and highlights areas for further research on health disparities. © American Academy of Otolaryngology—Head and Neck Surgery Foundation 2014.

Predicting High School Students' Interest in Majoring in a STEM Field: Insight into High School Students' Postsecondary Plans

ERIC Educational Resources Information Center

Lichtenberger, Eric; George-Jackson, Casey

2013-01-01

This study examined how various individual, family, and school level contextual factors impact the likelihood of planning to major in one of the science, technology, engineering, or mathematics (STEM) fields for high school students. A binary logistic regression model was developed to determine the extent to which each of the covariates helped to…

Evidence on Private Sector Training. Background Paper No. 7c.

ERIC Educational Resources Information Center

Ouweneel, William M.

Private sector training is a primary force in education in the United States for a number of reasons: (1) the sheer amount of such training makes it a major factor; (2) this training has a significant impact on the nation's productivity and competitiveness; (3) it plays a major role in creating innovative and cost-effective solutions to training…

What Are the Major Impact Factors on Research Performance of Young Doctorate Holders in Science in China: A USTC Survey

ERIC Educational Resources Information Center

Gu, Jibao; Lin, Yu; Vogel, Doug; Tian, Wen

2011-01-01

Doctoral graduate research performance (DRP) is recognized as one of the most critical indices for evaluation of the success of doctoral education. Doctoral graduates with high research performance directly reflect a higher ability in academic research and academic achievement. Consequently, identifying which factors influence DRP is potentially…

Accident hazard evaluation and control decisions on forested recreation sites

Treesearch

Lee A. Paine

1971-01-01

Accident hazard associated with trees on recreation sites is inherently concerned with probabilities. The major factors include the probabilities of mechanical failure and of target impact if failure occurs, the damage potential of the failure, and the target value. Hazard may be evaluated as the product of these factors; i.e., expected loss during the current...

Factors Impacting on Teachers' Job Satisfaction Related to Science Teaching: A Mixed Methods Study

ERIC Educational Resources Information Center

Song, S.; Mustafa, M.

2015-01-01

Science teachers' job satisfaction is identified as a major factor that affects the quality of a science program. This research investigated to what extent a science program supports science teachers in terms of curriculum materials or extracurricular activities. It also examined the relationships among schools' curriculum support, the number of…

Cryptic chytridiomycosis linked to climate and genetic variation in amphibian populations of the southeastern United States

PubMed Central

Hoffman, Eric A.; Tye, Matthew R.; Hether, Tyler D.; Savage, Anna E.

2017-01-01

North American amphibians have recently been impacted by two major emerging pathogens, the fungus Batrachochytrium dendrobatidis (Bd) and iridoviruses in the genus Ranavirus (Rv). Environmental factors and host genetics may play important roles in disease dynamics, but few studies incorporate both of these components into their analyses. Here, we investigated the role of environmental and genetic factors in driving Bd and Rv infection prevalence and severity in a biodiversity hot spot, the southeastern United States. We used quantitative PCR to characterize Bd and Rv dynamics in natural populations of three amphibian species: Notophthalmus perstriatus, Hyla squirella and Pseudacris ornata. We combined pathogen data, genetic diversity metrics generated from neutral markers, and environmental variables into general linear models to evaluate how these factors impact infectious disease dynamics. Occurrence, prevalence and intensity of Bd and Rv varied across species and populations, but only one species, Pseudacris ornata, harbored high Bd intensities in the majority of sampled populations. Genetic diversity and climate variables both predicted Bd prevalence, whereas climatic variables alone predicted infection intensity. We conclude that Bd is more abundant in the southeastern United States than previously thought and that genetic and environmental factors are both important for predicting amphibian pathogen dynamics. Incorporating both genetic and environmental information into conservation plans for amphibians is necessary for the development of more effective management strategies to mitigate the impact of emerging infectious diseases. PMID:28448517

Impact of Institution of a Stroke Program upon Referral Bias at a Rural Academic Medical Center

ERIC Educational Resources Information Center

Riggs, Jack E.; Libell, David P.; Brooks, Claudette E.; Hobbs, Gerald R.

2005-01-01

Context: Referral bias reflecting the preferential hospital transfer of patients with intracerebral hemorrhage (ICH) has been demonstrated as the major contributing factor for an observed high nonrisk-adjusted in-hospital crude acute stroke mortality rate at a rural academic medical center. Purpose: This study was done to assess the impact of a…

Impact of Institution of a Stroke Program Upon Referral Bias at a Rural Academic Medical Center

ERIC Educational Resources Information Center

Riggs, Jack E.; Libell, David P.; Brooks, Claudette E.; Hobbs, Gerald R.

2005-01-01

Context: Referral bias reflecting the preferential hospital transfer of patients with intracerebral hemorrhage (ICH) has been demonstrated as the major contributing factor for an observed high nonrisk-adjusted in-hospital crude acute stroke mortality rate at a rural academic medical center. Purpose: This study was done to assess the impact of a…

Pedagogy and Interactive White Board Technology Integration in Higher Education Institutions: Computer-Based Teaching Scenario Protoypes

ERIC Educational Resources Information Center

Al-Qirim, Nabeel; Mesmari, Ahlam; Mazroeei, Khawlah; Khatri, Shamma; Kaabi, Zuwainah

2017-01-01

This research is part of a research trilogy that investigated issues impacting Interactive White Board Technology (IWBT) adoption and use in a higher education institution. The other two research studies in this trilogy used (1) focus group approach and (2) survey research to identify such impacting factors. One major insight from these two…

The Major Impacts of the Baby Boom Cohort upon American Life, Past, Present and Future.

ERIC Educational Resources Information Center

Whaley, Charles E.

Impacts of the "Baby Boom" generation, the 75 million persons born between 1947 and 1962 in the United States, are analyzed. Factors influencing this unprecedented increase in birth rates included "catching up" by men who had been at war, a higher proportion of women in childbearing years, a decrease in the average marriage…

An Analysis of the Impact of the Work Information Management System (WIMS) on Civil Engineering Operations Managers’ Job Factors.

DTIC Science & Technology

1985-09-01

Organizational Politics. Robey (25:679) suggests a major vein of research of the impact of information technology has been the "political" intepretation . Robey...effectiveness. SA _UNCLASSIFIED SECURITY CLASIPICArION OIP THIS PAGI . . . . .... .". .. . .. . ." .. .. -.. " .’..’ ’. . .- - .’.’. . . -" .’ .. . . .- . .. . .. ,- . . . . . - . . . . - . - . . .. FILMED 12-85 DTIC ....

Capacity Estimation Model for Signalized Intersections under the Impact of Access Point

PubMed Central

Zhao, Jing; Li, Peng; Zhou, Xizhao

2016-01-01

Highway Capacity Manual 2010 provides various factors to adjust the base saturation flow rate for the capacity analysis of signalized intersections. No factors, however, is considered for the potential change of signalized intersections capacity caused by the access point closeing to the signalized intersection. This paper presented a theoretical model to estimate the lane group capacity at signalized intersections with the consideration of the effects of access points. Two scenarios of access point locations, upstream or downstream of the signalized intersection, and impacts of six types of access traffic flow are taken into account. The proposed capacity model was validated based on VISSIM simulation. Results of extensive numerical analysis reveal the substantial impact of access point on the capacity, which has an inverse correlation with both the number of major street lanes and the distance between the intersection and access point. Moreover, among the six types of access traffic flows, the access traffic flow 1 (right-turning traffic from major street), flow 4 (left-turning traffic from access point), and flow 5 (left-turning traffic from major street) cause a more significant effect on lane group capacity than others. Some guidance on the mitigation of the negative effect is provided for practitioners. PMID:26726998

Putting performance in context: the perceived influence of environmental factors on work-based performance.

PubMed

Stroud, Lynfa; Bryden, Pier; Kurabi, Bochra; Ginsburg, Shiphra

2015-10-01

Context shapes behaviours yet is seldom considered when assessing competence. Our objective was to explore attending physicians' and trainees' perceptions of the Internal Medicine Clinical Teaching Unit (CTU) environment and how they thought contextual factors affected their performance. 29 individuals recently completing CTU rotations participated in nine level-specific focus groups (2 with attending physicians, 3 with senior and 2 with junior residents, and 2 with students). Participants were asked to identify environmental factors on the CTU and to describe how these factors influenced their own performance across CanMEDS roles. Discussions were analyzed using constructivist grounded theory. Five major contextual factors were identified: Busyness, Multiple Hats, Other People, Educational Structures, and Hospital Resources and Policies. Busyness emerged as the most important, but all factors had a substantial perceived impact on performance. Participants felt their performance on the Manager and Scholar roles was most affected by environmental factors (mostly negatively, due to decreased efficiency and impact on learning). In complex workplace environments, numerous factors shape performance. These contextual factors and their impact need to be considered in observations and judgements made about performance in the workplace, as without this understanding conclusions about competency may be flawed.

Psychological Factors and Cardiac Risk And Impact of Exercise Training Programs—A Review of Ochsner Studies

PubMed Central

Lavie, Carl J.; Milani, Richard V.; Artham, Surya M.; Gilliland, Yvonne

2007-01-01

Although under-emphasized, substantial evidence indicates that psychological distress, especially depression, hostility, and anxiety, are risk factors for coronary heart disease (CHD) and affect recovery following major coronary heart disease events. We review several major studies from Ochsner Medical Center demonstrating the high prevalence of psychological distress in CHD patients and the marked benefits that occur following formal cardiac rehabilitation and exercise training programs. These benefits include reductions in psychological stress, improvements in CHD risk factors that accompany high stress, and reduced all-cause mortality. These data support the benefits of exercise training and increased levels of fitness to improve psychological stress and subsequent prognosis. PMID:21603539

Traffic safety in the U.S.: re-examining major opportunities.

PubMed

Sivak, Michael; Luoma, Juha; Flannagan, Michael J; Bingham, C Raymond; Eby, David W; Shope, Jean T

2007-01-01

This article examines five major road-safety risk factors: exceeding posted speed limits, not using safety belts, driving while intoxicated, nighttime driving, and young drivers. The importance of each of these factors is documented, known effective countermeasures (both policy and technology based) are discussed, and impediments to the implementation of these countermeasures in the United States are examined. Based on current understanding of the five major risk factors, and of the available countermeasures, there appear to be a variety of opportunities to make substantial gains in road safety using existing knowledge. The limited implementation of a variety of known countermeasures therefore appears to be inconsistent with high-level, strategic goals to improve road safety. Consequently, a recommendation is made to comprehensively re-examine the balance between the countermeasures discussed in this article and economic, mobility, and privacy concerns. IMPACT ON PUBLIC SAFETY: Such a re-examination is likely to result in broad support for these countermeasures, with a consequent major improvement in road safety.

Impact of revascularization and factors associated with limb salvage in patients with diabetic foot.

PubMed

Hinojosa, Carlos A; Boyer-Duck, Estefanía; Anaya-Ayala, Javier E; Núñez-Salgado, Ana E; Laparra-Escareno, Hugo; Lizola, René

2018-01-01

Diabetic foot is a common cause of hospitalization. To examine the impact of revascularization on lower limb salvage. Retrospective study of diabetic patients with foot ulcers. The extent of tissue loss was assessed according to the PEDIS and Wagner classifications, and revascularization indications and techniques were evaluated. Factors involved with major amputation and limb salvage were assessed with Fisher's and chi-square tests. A total of 307 patients with a mean age of 61 years were included in the study; 198 (64%) were males; 53 (17%) underwent limb revascularization, 26 (8%) with endovascular techniques and 27 (9%) with open surgery; 27 belonged to PEDIS grade 3 (51%) and 21 (41%) to Wagner's classification grade 4; 52% of revascularized patients required major amputation versus 25% of those without revascularization. Comorbidities, demographic variables, complications and mortality showed no differences when patients who required major amputation were compared with those who didn't. Despite revascularization, the limb was preserved in less than 50% of patients. Early referral to vascular surgery and appropriate patient-selection criteria might increase limb salvage. Copyright: © 2018 SecretarÍa de Salud.

A small field for fertile science: the low visibility of reproductive science in high impact journals.

PubMed

Duncan, Francesca E; Derman, Benjamin; Woodruff, Teresa K

2014-05-01

Our success as a field and as individuals in reproductive science and medicine relies on our ability to produce high quality work that has broad visibility and impact. A common metric for assessing such success is the quantity of publications that are published in journals with high impact factors. It is unclear, however, how frequently work related to reproductive science and medicine actually appears in what are considered the highest impact journals. To address this gap in knowledge, we first determined how the field of reproductive biology in general compared to other research areas in terms of composite journal impact factor. Second, using a targeted search approach in the PubMed database, we examined the relationship between a journal's impact factor and the number of reproductive research articles published per journal issue. We found that compared to other major scientific disciplines, our field lacks journals with impact factors above 4. In addition, primary original research articles on reproduction-irrespective of male or female search terms-do not appear often in high impact journals. Instead, there is an increased percentage of secondary reproductive literature in high impact journals compared to topic-specific journals of lower impact. There are likely several explanations for why reproductive science and medicine has low visibility, including the field's small relative size, its lack of a specific disease and associated strong advocacy, and its surrounding social, ethical, and political unease. Nevertheless, there are concrete actions we can take to minimize the role of impact factor in our evaluation while simultaneously increasing influence through global awareness of the importance and need for reproductive research.

Internet Access as a Structural Factor in Career Choice: A Comparison between Computing and Non-Computing Major Students

ERIC Educational Resources Information Center

Lotriet, Hugo; Matthee, Machdel; Alexander, Patricia

2011-01-01

The career choice model of Adya and Kaiser posits the availability of technology resources as a structural element impacting on career choice. The model distinguishes between accessibility at school and at home. Based on this theoretical point of departure and by arguing a link between choice of major and choice of field of career, this paper…

Analysis of Causes of Major Environmental Issues Occurring on Sea Coastlines of the Peter the Great Bay

NASA Astrophysics Data System (ADS)

Golikov, S. Yu; Dulepov, V. I.; Maiorov, I. S.

2017-11-01

The geoecological assessment of any territory or aquatic area is based on the evaluation of the natural resource potential, conditions and factors influencing its development as well as the analysis of major environmental issues that characterize the current regional state. The monitoring of water ecosystems under the conditions of anthropogenic impact on coastal areas is of significant importance within the study of the conservation and restoration of biodiversity, in the assessment of the dynamics of various environmental factors and their effects on ecosystems and on the bioresources management planning.

The cock, the Academy, and the best scientific journal in the world.

PubMed

Romanovsky, Andrej A

2015-01-01

The reader is invited to travel to Ancient Greece, contemporary Brazil, and other places in a fantasy search for the best scientific journal. This whimsical search does not rely on the impact factor, the most popular tool used in real life for finding good journals. Instead, it takes advantage of the so-called authority factor, a recently proposed alternative to the impact factor. The authority factor of a particular journal is the mean h-index (Hirsch's index) of the most suitable group of this journal's editors. Having no connection to any major function of scientific journals, and also being arbitrary (which group of editors to select?), this factor is poorly suited for any technical analysis, but it seems to work well for "small-talk" editorials and self-promotion by complacent editors. Interestingly, the highest authority factor we could find belongs to the journal Temperature. This claim, however, should not be taken too seriously.

Educators' Perceptions of School-Based Factors That Impact Their Effectiveness in Working with Students with Challenging Behaviors: A Pilot Investigation

ERIC Educational Resources Information Center

Bullock, Lyndal M.; Zolkoski, Stacie M.; Lusk, Mandy E.; Hovey, Katrina A.

2017-01-01

The purpose of the present study was to complete a pilot investigation to learn more about how educators who have had experience working with students with challenging behaviors perceive school-related challenges impacting their effectiveness. Further, information was gleaned as to what educators believe to be major issues faced in their…

Research requirements to improve safety of civil helicopters

NASA Technical Reports Server (NTRS)

Waters, K. T.

1977-01-01

Helicopter and fixed-wing accident data were reviewed and major accident causal factors were established. The impact of accidents on insurance rates was examined and the differences in fixed-wing and helicopter accident costs discussed. The state of the art in civil helicopter safety was compared to military helicopters. Goals were established based on incorporation of known technology and achievable improvements that require development, as well as administrative-type changes such as the impact of improved operational planning, training, and human factors effects. Specific R and D recommendations are provided with an estimation of the payoffs, timing, and development costs.

Retraction policies of top scientific journals ranked by impact factor.

PubMed

Resnik, David B; Wager, Elizabeth; Kissling, Grace E

2015-07-01

This study gathered information about the retraction policies of the top 200 scientific journals, ranked by impact factor. Editors of the top 200 science journals for the year 2012 were contacted by email. One hundred forty-seven journals (74%) responded to a request for information. Of these, 95 (65%) had a retraction policy. Of journals with a retraction policy, 94% had a policy that allows the editors to retract articles without authors' consent. The majority of journals in this sample had a retraction policy, and almost all of them would retract an article without the authors' permission.

National Software Capacity: Near-Term Study

DTIC Science & Technology

1990-05-01

Productivity Gains 17 2. Labor Markets and Human Resource Impacts on Capacity 21 2.1. Career Ladders 21 2.1.1. Industry 21 2.1.2. Civil Service 22 2.1.3...Inflows to and Outflows from Computer-Related Jobs 29 2.3.2. Inflows to and Outflows from the DoD Industrial Contractors 31 3. Major Impacts of Other...Factors on Capacity: 35 A Systems View 3.1. Organizational Impacts on Capacity 35 3.1.1. Requirements Specification and Changes 35 3.1.2. The Contracting

Velocity distribution of fragments of catastrophic impacts

NASA Technical Reports Server (NTRS)

Takagi, Yasuhiko; Kato, Manabu; Mizutani, Hitoshi

1992-01-01

Three dimensional velocities of fragments produced by laboratory impact experiments were measured for basalts and pyrophyllites. The velocity distribution of fragments obtained shows that the velocity range of the major fragments is rather narrow, at most within a factor of 3 and that no clear dependence of velocity on the fragment mass is observed. The NonDimensional Impact Stress (NDIS) defined by Mizutani et al. (1990) is found to be an appropriate scaling parameter to describe the overall fragment velocity as well as the antipodal velocity.

Performance of the Malay Audit of Diabetes Dependent Quality of Life-18 and Associates of Quality of Life among Patients with Type 2 Diabetes Mellitus from Major Ethnic Groups of Malaysia.

PubMed

Daher, Aqil M; AlMashoor, Syed Hassan A; Winn, Than

2016-01-01

Diabetes Mellitus (DM) is notorious for its metabolic effect, acute and chronic complications and impact on Quality of Life (QoL). Successful intervention to improve QoL necessitates a valid and reliable measurement tool to identify areas of concern to patients with diabetes. To (1) assess the factor structure of the Malay Audit of Diabetes Dependent Quality of Life-18 (ADDQoL-18) questionnaire; (2) determine the impact of DM on QoL; and (3) identify areas of concern to patients with type 2 DM from three major ethnic groups in Malaysia. Data was obtained from a cross sectional study involving 256 patients with type 2 DM attending the diabetes clinic of the National University of Malaysia Medical Centre. The Malay version of ADDQoL-18 survey was translated from its English version according to standard guidelines and administered by a trained research assistant. Exploratory Factor Analysis (EFA) with oblimin rotation was used to determine factor structure of the data. Confirmatory Factor Analysis (CFA) was used to confirm the factor structure. Hierarchical liner regression was used to determine factors associated with QoL. Unforced factor solution yielded two factors for the whole sample. Forced one factor solution was ascertained for the whole sample and for each ethnic group. Loadings ranged between 0.588 and 0.949. Reliability coefficients were all higher than 0.955. CFA showed that the two factor model had better fit statistics. QoL was associated with the use of insulin and desired glycaemic control, longer diabetes duration, worry about diabetes, and diabetes complications. The Malay ADDQoL-18 is a valid tool to be used among patients with diabetes from different ethnic groups in Malaysia. The use of insulin to achieve desired glycaemic control had more negative impact on QoL than the use of tablets and/or dietary changes.

Performance of the Malay Audit of Diabetes Dependent Quality of Life-18 and Associates of Quality of Life among Patients with Type 2 Diabetes Mellitus from Major Ethnic Groups of Malaysia

PubMed Central

Daher, Aqil M.; AlMashoor, Syed Hassan A.; Winn, Than

2016-01-01

Introduction Diabetes Mellitus (DM) is notorious for its metabolic effect, acute and chronic complications and impact on Quality of Life (QoL). Successful intervention to improve QoL necessitates a valid and reliable measurement tool to identify areas of concern to patients with diabetes. Objectives To (1) assess the factor structure of the Malay Audit of Diabetes Dependent Quality of Life-18 (ADDQoL-18) questionnaire; (2) determine the impact of DM on QoL; and (3) identify areas of concern to patients with type 2 DM from three major ethnic groups in Malaysia. Methods Data was obtained from a cross sectional study involving 256 patients with type 2 DM attending the diabetes clinic of the National University of Malaysia Medical Centre. The Malay version of ADDQoL-18 survey was translated from its English version according to standard guidelines and administered by a trained research assistant. Exploratory Factor Analysis (EFA) with oblimin rotation was used to determine factor structure of the data. Confirmatory Factor Analysis (CFA) was used to confirm the factor structure. Hierarchical liner regression was used to determine factors associated with QoL. Results Unforced factor solution yielded two factors for the whole sample. Forced one factor solution was ascertained for the whole sample and for each ethnic group. Loadings ranged between 0.588 and 0.949. Reliability coefficients were all higher than 0.955. CFA showed that the two factor model had better fit statistics. QoL was associated with the use of insulin and desired glycaemic control, longer diabetes duration, worry about diabetes, and diabetes complications. Conclusions The Malay ADDQoL-18 is a valid tool to be used among patients with diabetes from different ethnic groups in Malaysia. The use of insulin to achieve desired glycaemic control had more negative impact on QoL than the use of tablets and/or dietary changes. PMID:27695086

Source apportionment of particulate matter and trace gases near a major refinery near the Houston Ship Channel

NASA Astrophysics Data System (ADS)

Wallace, Henry W.; Sanchez, Nancy P.; Flynn, James H.; Erickson, Mathew H.; Lefer, Barry L.; Griffin, Robert J.

2018-01-01

From February 7 to 27, 2015, a mobile air quality laboratory was deployed to a location proximate to a major refinery, the Port of Houston, and several neighborhoods to conduct measurements of atmospheric trace gases and particulate matter. Two statistical models were utilized to apportion the sources of pollution impacting this site and the denizens of the nearby neighborhoods. Positive matrix factorization (PMF) was performed on the organic signal of the aerosol mass spectra, resulting in five factors totaling an average of 4.1 μg/m3 of the organic aerosol: hydrocarbon-like (0.67 μg/m3), cooking (0.35 μg/m3) biomass burning (1.14 μg/m3), low-volatility oxidized (1.15 μg/m3), and semi-volatile oxidized (0.78 μg/m3). Principal component analysis was performed on daytime and nighttime data, including concentrations from PMF output, of other PM1 components, and of trace gases. This generated five daytime and five nighttime factors that explained 74.5% and 73.0% of the variance, respectively. The most important factors impacting this site were from mobile source exhaust and petrochemical aromatic compound emissions. Together these two factors also constitute most of the observed carcinogens.

Social impacts of civil aviation and implications for R and D policy

NASA Technical Reports Server (NTRS)

Mayo, L. H.

1971-01-01

An attempt was made to identify social impacts, both beneficial and detrimental, which would or could flow from the introduction of advanced civil aviation systems. A broad range of social impact areas was investigated which included economic, environmental, political, sociological, psychological, legal, and urban/regional developmental factors. Data are arranged into two major parts. In the first part, a series of Major Policy Issues are identified and discussed which appear, on the basis of the social impact study, to merit serious consideration. The discussion of each "Issue' is presented both to explain its relevance and to raise considerations which will bear on its satisfactory resolution. The second part views the same overall body of information in a different manner: a series of "Findings' are pointed out from which more concrete guidance for R and D policy can be derived, and a set of "Candidate Basic Federal Undertakings' thus derived are presented.

The Past Does Matter: a Nursing Perspective on Post Traumatic Slave Syndrome (PTSS).

PubMed

Sule, Ejim; Sutton, Ryan M; Jones, Debbie; Moore, Ramel; Igbo, Imaculata; Jones, Lovell A

2017-01-11

Few have reviewed the impact of post traumatic slave syndrome (PTSS) on the issues of inequities, especially as it pertains to mental and physical health. Furthermore, the impact of PTSS on the social determinants of health is an area that has been researched by few investigators. The possibilities that the impact of slavery and/or major stress events in the life of a population can become trans-generational are lost to history. Think about what is taking place in cities around the country and then think about racist socialization (internalized racism) and its impact on our society. Combining these factors with the lack of real medical care and the bias that plagues our medical establishment and society in general, the net result is a society faced with inequities that seem to be unresolvable, simply because we have lost perspective about a major root cause of the problem.

The impact of article length on the number of future citations: a bibliometric analysis of general medicine journals.

PubMed

Falagas, Matthew E; Zarkali, Angeliki; Karageorgopoulos, Drosos E; Bardakas, Vangelis; Mavros, Michael N

2013-01-01

The number of citations received is considered an index of study quality and impact. We aimed to examine the factors associated with the number of citations of published articles, focusing on the article length. Original human studies published in the first trimester of 2006 in 5 major General Medicine journals were analyzed with regard to the number of authors and of author-affiliated institutions, title and abstract word count, article length (number of print pages), number of bibliographic references, study design, and 2006 journal impact factor (JIF). A multiple linear regression model was employed to identify the variables independently associated with the number of article citations received through January 2012. On univariate analysis the JIF, number of authors, article length, study design (interventional/observational and prospective/retrospective), title and abstract word count, number of author-affiliated institutions, and number of references were all associated with the number of citations received. On multivariate analysis with the logarithm of citations as the dependent variable, only article length [regression coefficient: 14.64 (95% confidence intervals: (5.76-23.50)] and JIF [3.37 (1.80-4.948)] independently predicted the number of citations. The variance of citations explained by these parameters was 51.2%. In a sample of articles published in major General Medicine journals, in addition to journal impact factors, article length and number of authors independently predicted the number of citations. This may reflect a higher complexity level and quality of longer and multi-authored studies.

Effect of magnetic field on seed germination and seedling growth of sunflower

NASA Astrophysics Data System (ADS)

Matwijczuk, A.; Kornarzyński, K.; Pietruszewski, S.

2012-07-01

The impact of a variable magnetic field, magnetically treated water and a combination of both these factors on the germination of seeds and the final mass at the initial stage of growth sunflower plants was presented. Investigations were carried out in pots filled with sand, tin an air-conditioned plant house with no access to daylight using fluorescent light as illumination. A statistical significance positive impact was achieved for the samples subjected to the interaction of both stimulating factors simultaneously, the magnetic field and the impact of treated water several times on the speed of seed germination and final plant mass. Negative impacts were obtained for the majority of the test cases, for the magnetically treated water, the short duration of activity of the magnetic field and for the connection of the magnetic field and low-flow times.

[Epidemiology of osteoporosis].

PubMed

Grazio, Simeon

2006-01-01

Osteoporosis represents a major and increasing public health problem with the aging of population. Major clinical consequences and economic burden of the disease are fractures. Many risk factors are associated with the fractures including low bone mass, hormonal disorders, personal and family history of fractures, low body weight, use of certain drugs (e.g. glucocorticoids), cigarette smoking, elevated intake of alchohol, low physical activity, insufficient level of vitamin D and low intake of calcium. This epidemiological review describes frequency, importance of risk factors and impact of osteoporosis and osteoporotic fractures. Objective measures of bone mineral density along with clinical assessment of risk factors can help identify patients who will benefit from prevention and intervention efforts and eventually reduce the morbidity and mortality associated with osteoporosis-related fractures.

Prevalence of Sarcopenia and Its Impact on Postoperative Outcome in Patients With Crohn's Disease Undergoing Bowel Resection.

PubMed

Zhang, Tenghui; Cao, Lei; Cao, Tingzhi; Yang, Jianbo; Gong, Jianfeng; Zhu, Weiming; Li, Ning; Li, Jieshou

2017-05-01

Sarcopenia has been proposed to be a prognostic factor of outcomes for various diseases but has not been applied to Crohn's disease (CD). We aimed to assess the impact of sarcopenia on postoperative outcomes after bowel resection in patients with CD. Abdominal computed tomography images within 30 days before bowel resection in 114 patients with CD between May 2011 and March 2014 were assessed for sarcopenia as well as visceral fat areas and subcutaneous fat areas. The impact of sarcopenia on postoperative outcomes was evaluated using univariate and multivariate analyses. Of 114 patients, 70 (61.4%) had sarcopenia. Patients with sarcopenia had a lower body mass index, lower preoperative levels of serum albumin, and more major complications (15.7% vs 2.3%, P = .027) compared with patients without sarcopenia. Moreover, predictors of major postoperative complications were sarcopenia (odds ratio [OR], 9.24; P = .04) and a decreased skeletal muscle index (1.11; P = .023). Preoperative enteral nutrition (OR, 0.13; P = .004) and preoperative serum albumin level >35 g/L (0.19; P = .017) were protective factors in multivariate analyses. The prevalence of sarcopenia is high in patients with CD requiring bowel resection. It significantly increases the risk of major postoperative complications and has clinical implications with respect to nutrition management before surgery for CD.

Revolution or Evolution: Combined Arms Warfare in the Twenty-First Century

DTIC Science & Technology

1999-06-04

of the relationship of technological development and its impact on the military . Technology has always been a major factor in the initiation, execution...this technology revolutionized warfare? 1 There has been much argument lately that the U.S. Army is participating in the latest revolution in military ...their impact on strategic concerns: The emergence of technology that has military applications is accelerating, but revolutionary changes in military

An independent component analysis confounding factor correction framework for identifying broad impact expression quantitative trait loci

PubMed Central

Ju, Jin Hyun; Crystal, Ronald G.

2017-01-01

Genome-wide expression Quantitative Trait Loci (eQTL) studies in humans have provided numerous insights into the genetics of both gene expression and complex diseases. While the majority of eQTL identified in genome-wide analyses impact a single gene, eQTL that impact many genes are particularly valuable for network modeling and disease analysis. To enable the identification of such broad impact eQTL, we introduce CONFETI: Confounding Factor Estimation Through Independent component analysis. CONFETI is designed to address two conflicting issues when searching for broad impact eQTL: the need to account for non-genetic confounding factors that can lower the power of the analysis or produce broad impact eQTL false positives, and the tendency of methods that account for confounding factors to model broad impact eQTL as non-genetic variation. The key advance of the CONFETI framework is the use of Independent Component Analysis (ICA) to identify variation likely caused by broad impact eQTL when constructing the sample covariance matrix used for the random effect in a mixed model. We show that CONFETI has better performance than other mixed model confounding factor methods when considering broad impact eQTL recovery from synthetic data. We also used the CONFETI framework and these same confounding factor methods to identify eQTL that replicate between matched twin pair datasets in the Multiple Tissue Human Expression Resource (MuTHER), the Depression Genes Networks study (DGN), the Netherlands Study of Depression and Anxiety (NESDA), and multiple tissue types in the Genotype-Tissue Expression (GTEx) consortium. These analyses identified both cis-eQTL and trans-eQTL impacting individual genes, and CONFETI had better or comparable performance to other mixed model confounding factor analysis methods when identifying such eQTL. In these analyses, we were able to identify and replicate a few broad impact eQTL although the overall number was small even when applying CONFETI. In light of these results, we discuss the broad impact eQTL that have been previously reported from the analysis of human data and suggest that considerable caution should be exercised when making biological inferences based on these reported eQTL. PMID:28505156

An independent component analysis confounding factor correction framework for identifying broad impact expression quantitative trait loci.

PubMed

Ju, Jin Hyun; Shenoy, Sushila A; Crystal, Ronald G; Mezey, Jason G

2017-05-01

Genome-wide expression Quantitative Trait Loci (eQTL) studies in humans have provided numerous insights into the genetics of both gene expression and complex diseases. While the majority of eQTL identified in genome-wide analyses impact a single gene, eQTL that impact many genes are particularly valuable for network modeling and disease analysis. To enable the identification of such broad impact eQTL, we introduce CONFETI: Confounding Factor Estimation Through Independent component analysis. CONFETI is designed to address two conflicting issues when searching for broad impact eQTL: the need to account for non-genetic confounding factors that can lower the power of the analysis or produce broad impact eQTL false positives, and the tendency of methods that account for confounding factors to model broad impact eQTL as non-genetic variation. The key advance of the CONFETI framework is the use of Independent Component Analysis (ICA) to identify variation likely caused by broad impact eQTL when constructing the sample covariance matrix used for the random effect in a mixed model. We show that CONFETI has better performance than other mixed model confounding factor methods when considering broad impact eQTL recovery from synthetic data. We also used the CONFETI framework and these same confounding factor methods to identify eQTL that replicate between matched twin pair datasets in the Multiple Tissue Human Expression Resource (MuTHER), the Depression Genes Networks study (DGN), the Netherlands Study of Depression and Anxiety (NESDA), and multiple tissue types in the Genotype-Tissue Expression (GTEx) consortium. These analyses identified both cis-eQTL and trans-eQTL impacting individual genes, and CONFETI had better or comparable performance to other mixed model confounding factor analysis methods when identifying such eQTL. In these analyses, we were able to identify and replicate a few broad impact eQTL although the overall number was small even when applying CONFETI. In light of these results, we discuss the broad impact eQTL that have been previously reported from the analysis of human data and suggest that considerable caution should be exercised when making biological inferences based on these reported eQTL.

Impact of forest liming on growth, vigor, and reproduction of sugar maple and associated hardwoods

Treesearch

Robert P. Long; Stephen B. Horsley; Paul R. Lilja

1999-01-01

In 1985 a long-term study was initiated by the Pennsylvania Bureau of Forestry and the Northeastern Research Station to evaluate factors impeding regeneration of Allegheny hardwoods (Auchmoody, unpublished). The major factors suspected of limiting regeneration were high soil aluminum levels associated with low soil pH (typically 3.6 to 4.2 in surface mineral soils),...

Cosmetic Liposuction: Preoperative Risk Factors, Major Complication Rates, and Safety of Combined Procedures.

PubMed

Kaoutzanis, Christodoulos; Gupta, Varun; Winocour, Julian; Layliev, John; Ramirez, Roberto; Grotting, James C; Higdon, Kent

2017-06-01

Liposuction is among the most commonly performed aesthetic procedures, and is being performed increasingly as an adjunct to other procedures. To report the incidence and risk factors of significant complications after liposuction, and to determine whether adding liposuction to other cosmetic surgical procedures impacts the complication risk. A prospective cohort of patients who underwent liposuction between 2008 and 2013 was identified from the CosmetAssure database. Primary outcome was occurrence of major complications requiring emergency room visit, hospital admission, or reoperation within 30 days of the operation. Univariate and multivariate analysis evaluated risk factors including age, gender, body mass index (BMI), smoking, diabetes, type of surgical facility, and combined procedures. Of the 31,010 liposuction procedures, only 11,490 (37.1%) were performed as a solitary procedure. Liposuction alone had a major complication rate of 0.7% with hematoma (0.15%), pulmonary complications (0.1%), infection (0.1%), and confirmed venous thromboembolism (VTE) (0.06%) being the most common. Independent predictors of major complications included combined procedures (Relative Risk (RR) 4.81), age (RR 1.01), BMI (RR 1.05), and procedures performed in hospitals (RR 1.36). When examining specifically other aesthetic procedures performed alone or with liposuction, combined procedures had a higher risk of confirmed VTE (RR 5.65), pulmonary complications (RR 2.72), and infection (RR 2.41), but paradoxically lower hematoma risk (RR 0.77) than solitary procedures. Liposuction performed alone is a safe procedure with a low risk of major complications. Combined procedures, especially on obese or older individuals, can significantly increase complication rates. The impact of liposuction on the risk of hematoma in combined procedures needs further investigation. © 2017 The American Society for Aesthetic Plastic Surgery, Inc. Reprints and permission: journals.permissions@oup.com

Weighing the impact (factor) of publishing in veterinary journals.

PubMed

Christopher, Mary M

2015-06-01

The journal in which you publish your research can have a major influence on the perceived value of your work and on your ability to reach certain audiences. The impact factor, a widely used metric of journal quality and prestige, has evolved into a benchmark of quality for institutions and graduate programs and, inappropriately, as a proxy for the quality of individual authors and articles, affecting tenure, promotion, and funding decisions. As a result, despite its many limitations, publishing decisions by authors often are based solely on a journal's impact factor. This can disadvantage journals in small disciplines, such as veterinary medicine, and limit the ability of authors to reach key audiences. In this article, factors that can influence the impact factor of a journal and its applicability, including precision, citation practices, article type, editorial policies, and size of the research community will be reviewed. The value and importance of veterinary journals such as the Journal of Veterinary Cardiology for reaching relevant audiences and for helping shape disciplinary specialties and influence clinical practice will also be discussed. Lastly, the efforts underway to develop alternative measures to assess the scientific quality of individual authors and articles, such as article-level metrics, as well as institutional measures of the economic and social impact of biomedical research will be considered. Judicious use of the impact factor and the implementation of new metrics for assessing the quality and societal relevance of veterinary research articles will benefit both authors and journals. Copyright © 2015 Elsevier B.V. All rights reserved.

Climate Change Impact on Sugarcane Production in Developing Countries

USDA-ARS?s Scientific Manuscript database

A combination of long-term change in the weather patterns worldwide (Global climate change), caused by natural processes and anthropogenic factors, may result in major environmental issues that have affected and will continuously affect agriculture. Increases in atmospheric carbon dioxide concentrat...

77 FR 68738 - Procurement List; Additions

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-16

... a significant impact on a substantial number of small entities. The major factors considered for... other compliance requirements for small entities other than the small organizations that will furnish the products and services to the Government. 2. The action will result in authorizing small entities...

Influence of Smoking Puff Parameters and Tobacco Varieties on Free Radicals Yields in Cigarette Mainstream Smoke.

PubMed

Goel, Reema; Bitzer, Zachary T; Reilly, Samantha M; Foulds, Jonathan; Muscat, Joshua; Elias, Ryan J; Richie, John P

2018-05-07

Cigarette smoke is a major exogenous source of free radicals, and the resulting oxidative stress is one of the major causes of smoking-caused diseases. Yet, many of the factors that impact free radical delivery from cigarettes remain unclear. In this study, we machine-smoked cigarettes and measured the levels of gas- and particulate-phase radicals by electron paramagnetic resonance (EPR) spectroscopy using standardized smoking regimens (International Organization of Standardization (ISO) and Canadian Intense (CI)), puffing parameters, and tobacco blends. Radical delivery per cigarette was significantly greater in both gas (4-fold) and particulate (6-fold) phases when cigarettes were smoked under the CI protocol compared to the ISO protocol. Total puff volume per cigarette was the major factor with radical production being proportional to total volume, regardless of whether volume differences were achieved by changes in individual puff volume or puff frequency. Changing puff shape (bell vs sharp vs square) or puff duration (1-5 s), without changing volume, had no effect on radical yields. Tobacco variety did have a significant impact on free radical production, with gas-phase radicals highest in reconstituted > burley > oriental > bright tobacco and particulate-phase radicals highest in burley > bright > oriental > reconstituted tobacco. Our findings show that modifiable cigarette design features and measurable user smoking behaviors are key factors determining free radical exposure in smokers.

Impact of NAVSTAR Global Positioning System on Military Plans for Navigation and Position Fixing Systems

DTIC Science & Technology

1975-10-01

There are however significant factors evident in the study , but not amenable to fiscal quantifi- cation that provide impetus for employment of GPS...assumed in this study . (For summary of these factors , see Section A.2.a, page 25, in the. Discussion.) C These ranges of GPS cost, as well as the...this study . However, they may be a major factor in the teasibility of eliminating the single Doppler, which would be a significant added cost avoidance

iDriving (Intelligent Driving)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Malikopoulos, Andreas

2012-09-17

iDriving identifies the driving style factors that have a major impact on fuel economy. An optimization framework is used with the aim of optimizing a driving style with respect to these driving factors. A set of polynomial metamodels is constructed to reflect the responses produced in fuel economy by changing the driving factors. The optimization framework is used to develop a real-time feedback system, including visual instructions, to enable drivers to alter their driving styles in responses to actual driving conditions to improve fuel efficiency.

Effects of air pollution on human health and practical measures for prevention in Iran

PubMed Central

Ghorani-Azam, Adel; Riahi-Zanjani, Bamdad; Balali-Mood, Mahdi

2016-01-01

Air pollution is a major concern of new civilized world, which has a serious toxicological impact on human health and the environment. It has a number of different emission sources, but motor vehicles and industrial processes contribute the major part of air pollution. According to the World Health Organization, six major air pollutants include particle pollution, ground-level ozone, carbon monoxide, sulfur oxides, nitrogen oxides, and lead. Long and short term exposure to air suspended toxicants has a different toxicological impact on human including respiratory and cardiovascular diseases, neuropsychiatric complications, the eyes irritation, skin diseases, and long-term chronic diseases such as cancer. Several reports have revealed the direct association between exposure to the poor air quality and increasing rate of morbidity and mortality mostly due to cardiovascular and respiratory diseases. Air pollution is considered as the major environmental risk factor in the incidence and progression of some diseases such as asthma, lung cancer, ventricular hypertrophy, Alzheimer's and Parkinson's diseases, psychological complications, autism, retinopathy, fetal growth, and low birth weight. In this review article, we aimed to discuss toxicology of major air pollutants, sources of emission, and their impact on human health. We have also proposed practical measures to reduce air pollution in Iran. PMID:27904610

Effects of air pollution on human health and practical measures for prevention in Iran.

PubMed

Ghorani-Azam, Adel; Riahi-Zanjani, Bamdad; Balali-Mood, Mahdi

2016-01-01

Air pollution is a major concern of new civilized world, which has a serious toxicological impact on human health and the environment. It has a number of different emission sources, but motor vehicles and industrial processes contribute the major part of air pollution. According to the World Health Organization, six major air pollutants include particle pollution, ground-level ozone, carbon monoxide, sulfur oxides, nitrogen oxides, and lead. Long and short term exposure to air suspended toxicants has a different toxicological impact on human including respiratory and cardiovascular diseases, neuropsychiatric complications, the eyes irritation, skin diseases, and long-term chronic diseases such as cancer. Several reports have revealed the direct association between exposure to the poor air quality and increasing rate of morbidity and mortality mostly due to cardiovascular and respiratory diseases. Air pollution is considered as the major environmental risk factor in the incidence and progression of some diseases such as asthma, lung cancer, ventricular hypertrophy, Alzheimer's and Parkinson's diseases, psychological complications, autism, retinopathy, fetal growth, and low birth weight. In this review article, we aimed to discuss toxicology of major air pollutants, sources of emission, and their impact on human health. We have also proposed practical measures to reduce air pollution in Iran.

Generation of Recombinant Human AChE OP-Scavengers with Extended Circulatory Longevity

DTIC Science & Technology

2006-11-01

PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Avigdor Shafferman Ph.D. 5d. PROJECT NUMBER 5e. TASK NUMBER E-Mail: avigdor...glycans of rHuAChE, and in particular the distal termini of these glycan 8 projections , constitute a major factor in determining the circulatory...experiments funded by sources other than the USAMRMC contract, since they may have a major impact on the present project . Section III focuses on the

Dayside ionosphere of Titan: Impact on calculated plasma densities due to variations in the model parameters

NASA Astrophysics Data System (ADS)

Mukundan, Vrinda; Bhardwaj, Anil

2018-01-01

A one dimensional photochemical model for the dayside ionosphere of Titan has been developed for calculating the density profiles of ions and electrons under steady state photochemical equilibrium condition. We concentrated on the T40 flyby of Cassini orbiter and used the in-situ measurements from instruments onboard Cassini as input to the model. An energy deposition model is employed for calculating the attenuated photon flux and photoelectron flux at different altitudes in Titan's ionosphere. We used the Analytical Yield Spectrum approach for calculating the photoelectron fluxes. Volume production rates of major primary ions, like, N2+, N+ , CH4+, CH3+, etc due to photon and photoelectron impact are calculated and used as input to the model. The modeled profiles are compared with the Cassini Ion Neutral Mass Spectrometer (INMS) and Langmuir Probe (LP) measurements. The calculated electron density is higher than the observation by a factor of 2 to 3 around the peak. We studied the impact of different model parameters, viz. photoelectron flux, ion production rates, electron temperature, dissociative recombination rate coefficients, neutral densities of minor species, and solar flux on the calculated electron density to understand the possible reasons for this discrepancy. Recent studies have shown that there is an overestimation in the modeled photoelectron flux and N2+ ion production rates which may contribute towards this disagreement. But decreasing the photoelectron flux (by a factor of 3) and N2+ ion production rate (by a factor of 2) decreases the electron density only by 10 to 20%. Reduction in the measured electron temperature by a factor of 5 provides a good agreement between the modeled and observed electron density. The change in HCN and NH3 densities affects the calculated densities of the major ions (HCNH+ , C2H5+, and CH5+); however the overall impact on electron density is not appreciable ( < 20%). Even though increasing the dissociative recombination rate coefficients of the ions C2H5+ and CH5+ by a factor of 10 reduces the difference between modeled and observed densities of the major ions, the modeled electron density is still higher than the observation by ∼ 60% at the peak. We suggest that there might be some unidentified chemical reactions that may account for the additional loss of plasma in Titan's ionosphere.

Geographic and socioeconomic factors in patients with malignant pleural mesothelioma in New South Wales and their impact upon clinical outcomes.

PubMed

Linton, Anthony; Soeberg, Matthew; Broome, Richard; Kao, Steven; van Zandwijk, Nico

2017-07-01

Whilst the impact of clinicopathological factors on the prognosis of malignant pleural mesothelioma (MPM) is well understood, socioeconomic and geographic factors have received less attention. We analysed the relationship between geographic and socioeconomic factors upon survival and treatment provision in a large series of patients with MPM. We assessed MPM patients awarded compensation between 2002 and 2009 with additional MPM incidence data from the New South Wales (NSW) Cancer Registry. The impact of geographic remoteness, distance from oncological multidisciplinary team (MDT) and Index of Relative Socioeconomic Advantage and Disadvantage (IRSAD) upon survival, clinical features and treatment received was analysed. We identified 910 patients (67% residing in major cities; 92% <50 km from MDT). Median overall survival was 10.0 months. On multivariate analysis, age >70 (hazard ratio (HR) = 1.39), male gender (HR =1.36), non-epithelioid histological subtype (HR = 2.18) and IRSAD status by decreasing quintile (HR = 1.06) were independent prognostic factors. There was no significant advantage for patients residing in major cities (10.6 months vs 8.8 months; P = 0.162) or within 50 km of MDT (10.3 months vs 7.8 months; P = 0.539). Patient's geographic location and distance to MDT did not impact chemotherapy, adjuvant radiotherapy or extrapleural pneumonectomy provision. Socioeconomically disadvantaged patients were significantly less likely to receive chemotherapy (37.4% vs 54.8%; P = 0.001). This study provides evidence for differences in the treatment and survival according to socioeconomic status for compensated MPM patients in NSW. Further research is warranted to seek additional explanations for the differences noted by comparing the treatments and outcomes of compensated and non-compensated MPM patients in NSW. © 2017 Asian Pacific Society of Respirology.

The potential impact of a social redistribution of specific risk factors on socioeconomic inequalities in mortality: illustration of a method based on population attributable fractions.

PubMed

Hoffmann, Rasmus; Eikemo, Terje Andreas; Kulhánová, Ivana; Dahl, Espen; Deboosere, Patrick; Dzúrová, Dagmar; van Oyen, Herman; Rychtaríková, Jitka; Strand, Bjørn Heine; Mackenbach, Johan P

2013-01-01

Socioeconomic differences in health are a major challenge for public health. However, realistic estimates to what extent they are modifiable are scarce. This problem can be met through the systematic application of the population attributable fraction (PAF) to socioeconomic health inequalities. The authors used cause-specific mortality data by educational level from Belgium, Norway and Czech Republic and data on the prevalence of smoking, alcohol, lack of physical activity and high body mass index from national health surveys. Information on the impact of these risk factors on mortality comes from the epidemiological literature. The authors calculated PAFs to quantify the impact on socioeconomic health inequalities of a social redistribution of risk factors. The authors developed an Excel tool covering a wide range of possible scenarios and the authors compare the results of the PAF approach with a conventional regression. In a scenario where the whole population gets the risk factor prevalence currently seen among the highly educated inequalities in mortality can be reduced substantially. According to the illustrative results, the reduction of inequality for all risk factors combined varies between 26% among Czech men and 94% among Norwegian men. Smoking has the highest impact for both genders, and physical activity has more impact among women. After discussing the underlying assumptions of the PAF, the authors concluded that the approach is promising for estimating the extent to which health inequalities can be potentially reduced by interventions on specific risk factors. This reduction is likely to differ substantially between countries, risk factors and genders.

Mathematical Modeling of Flow Through Vegetated Regions

DTIC Science & Technology

2013-08-01

interested me the most, while always reminding me of practical concerns and broader impact . I look forward to more collaboration in the future. I want...affects the flow resistance, which is a major factor in determining velocity and pressure distribution. The main impact of vege- tation on flow is form...in a flume with a variety of spacings and for a large range of Reynolds numbers. They used acoustic Doppler velocime- ters that measure velocity and

The 100 most-cited articles on non-tuberculous mycobacterial infection from 1995 to 2015.

PubMed

Jhun, B W; Kim, S-Y; Kong, J H; Park, J R; Park, S Y; Shim, M A; Jeon, K; Park, H Y; Shin, S J; Koh, W-J

2017-01-01

Citation analyses aid in assessing quality, trends and future directions of research fields. To identify the most influential articles on infections caused by non-tuberculous mycobacteria (NTM) in the last 20 years. We performed a cited reference search of the Web of Science database from 1995 to 2015. The 100 most cited articles on NTM infections were analysed. The top 100 articles were cited 114-1471 times, and were published from 1995 to 2013. Sixty-five were laboratory-based, basic science articles, with the major topics being pathophysiology (n = 20) and molecular methods for NTM identification (n = 15). Among the 35 non-laboratory studies, major topics were clinical management (n = 15) and epidemiology (n = 14). The top article was a clinical treatise on the management of NTM disease, published in 2007. Although there was a correlation between article rank and journal impact factor (P = 0.043, ρ = -0.202), the five articles from the journals with highest impact factors did not rank among the top 10 articles. A large proportion of influential articles on NTM infection are basic scientific studies, and the most influential articles are not always published in high-impact journals.

Brains in the City: Neurobiological effects of urbanization

PubMed Central

Lambert, Kelly G.; Nelson, Randy J.; Jovanovic, Tanja; Cerdá, Magdalena

2016-01-01

With a majority of humans now living in cities, strategic research is necessary to elucidate the impact of this evolutionarily unfamiliar habitat on neural functions and well-being. In this review, both rodent and human models are considered in the evaluation of the changing physical and social landscapes associated with urban dwellings. Animal models assessing increased exposure to artificial physical elements characteristic of urban settings, as well as exposure to unnatural sources of light for extended durations, are reviewed. In both cases, increased biomarkers of mental illnesses such as major depression have been observed. Additionally, applied human research emphasizing the emotional impact of environmental threats associated with urban habitats is considered. Subjects evaluated in an inner-city hospital reveal the impact of combined specific genetic vulnerabilities and heightened stress responses in the expression of posttraumatic stress disorder. Finally, algorithm-based models of cities have been developed utilizing population-level analyses to identify risk factors for psychiatric illness. Although complex, the use of multiple research approaches, as described herein, results in an enhanced understanding of urbanization and its far-reaching effects--confirming the importance of continued research directed toward the identification of putative risk factors associated with psychiatric illness in urban settings. PMID:25936504

A community survey on knowledge of the impact of environmental and epigenetic factors on health and disease.

PubMed

Miller, Marian; Bailey, Banita; Govindarajah, Vinothini; Levin, Linda; Metzger, Traci; Pinney, Susan M; Leung, Yuet-Kin; Ho, Shuk-Mei

2016-11-01

An outreach effort was designed to survey breast cancer survivors, supporters and their families and friends with respect to their interest in, and knowledge of, the potential impact of the environment and epigenetics on health. Two nearly identical questionnaires (one for adolescents and one for adults) were designed to gauge the perception of this community as to whether the environment impacts health and cancer risk through processes other than genetics. The questionnaires were filled out at casual social gatherings, fundraisers and wellness campaigns as well as in schools (730 participants). The differences among correct (scientific consensus) versus other responses (incorrect and not known) were evaluated. Each answer was first analysed individually and then grouped into one of three categories (diet, inheritance and environment) with age, race and gender. Differences for each response, question or group were compared by repeated measures analysis of variance. Respondents generally acknowledged that many factors could be associated with breast cancer although answers to key questions related to epigenetics based on diet, inheritance and environment were often incorrect or not known. The adult participants tended to answer more questions correctly than adolescents did. The majority of participants preferred the Internet as a major source for obtaining further information. The growing awareness and educational needs for adolescents may bring new paradigm-related environmental risk factors, which may minimise negative epigenetic outcome in subsequent generations. There is an educational opportunity, especially using electronic media, for public education concerning the impact of the environment on human health. © Royal Society for Public Health 2016.

Validation of the Contextual Assessment Inventory for Problem Behavior

ERIC Educational Resources Information Center

Carr, Edward G.; Ladd, Mara V.; Schulte, Christine F.

2008-01-01

Problem behavior is a major barrier to successful community integration for people with developmental disabilities. Recently, there has been increased interest in identifying contextual factors involving setting events and discriminative stimuli that impact the display of problem behavior. The authors previously developed the "Contextual…

Leachate generation from landfill in a semi-arid climate: A qualitative and quantitative study from Sousse, Tunisia.

PubMed

Frikha, Youssef; Fellner, Johann; Zairi, Moncef

2017-09-01

Despite initiatives for enhanced recycling and waste utilization, landfill still represents the dominant disposal path for municipal solid waste (MSW). The environmental impacts of landfills depend on several factors, including waste composition, technical barriers, landfill operation and climatic conditions. A profound evaluation of all factors and their impact is necessary in order to evaluate the environmental hazards emanating from landfills. The present paper investigates a sanitary landfill located in a semi-arid climate (Tunisia) and highlights major differences in quantitative and qualitative leachate characteristics compared to landfills situated in moderate climates. Besides the qualitative analysis of leachate samples, a quantitative analysis including the simulation of leachate generation (using the HELP model) has been conducted. The results of the analysis indicate a high load of salts (Cl, Na, inorganic nitrogen) in the leachate compared to other landfills. Furthermore the simulations with HELP model highlight that a major part of the leachate generated originates form the water content of waste.

The performance environment of the England youth soccer teams: a quantitative investigation.

PubMed

Pain, Matthew A; Harwood, Chris G

2008-09-01

We examined the performance environment of the England youth soccer teams. Using a conceptually grounded questionnaire developed from the themes identified by Pain and Harwood (2007), 82 players and 23 national coaches and support staff were surveyed directly following international tournaments regarding the factors that positively and negatively influenced performance. The survey enabled data to be captured regarding both the extent and magnitude of the impact of the factors comprising the performance environment. Overall, team and social factors were generally perceived to have the greatest positive impact, with players and staff showing high levels of consensus in their evaluations. Team leadership and strong team cohesion were identified by both groups as having the greatest positive impact. Overall, far fewer variables were perceived to have a negative impact on performance, especially for players. The main negatives common to both groups were players losing composure during games, player boredom, and a lack of available activities in the hotel. The major findings support those of Pain and Harwood (2007) and in using a larger sample helped to corroborate and strengthen the generalizability of the findings.

The sleepy adolescent: causes and consequences of sleepiness in teens.

PubMed

Moore, Melisa; Meltzer, Lisa J

2008-06-01

The majority of adolescents do not obtain the recommended amount of sleep, resulting in significant daytime sleepiness. For most adolescents, insufficient sleep results from the interaction between intrinsic factors such as puberty and extrinsic factors such as school start times. Insufficient sleep and sleepiness impact all areas of adolescent functioning, including academic, psychological and behavioural, which underscores the importance of evaluating sleepy adolescents. While polysomnography is required for the diagnosis of certain sleep disorders, causes of sleepiness are generally best identified with a detailed sleep history and daily sleep diary. The management of sleep problems in adolescents involves treating any underlying sleep disorders, increasing total sleep time and improving other environmental factors that impact sleep. Recognition and management of insufficient sleep and sleepiness is important for the health and functioning of adolescents.

Shared Risk Factors in Cardiovascular Disease and Cancer.

PubMed

Koene, Ryan J; Prizment, Anna E; Blaes, Anne; Konety, Suma H

2016-03-15

Cardiovascular disease (CVD) and cancer are the 2 leading causes of death worldwide. Although commonly thought of as 2 separate disease entities, CVD and cancer possess various similarities and possible interactions, including a number of similar risk factors (eg, obesity, diabetes mellitus), suggesting a shared biology for which there is emerging evidence. Although chronic inflammation is an indispensable feature of the pathogenesis and progression of both CVD and cancer, additional mechanisms can be found at their intersection. Therapeutic advances, despite improving longevity, have increased the overlap between these diseases, with millions of cancer survivors now at risk of developing CVD. Cardiac risk factors have a major impact on subsequent treatment-related cardiotoxicity. In this review, we explore the risk factors common to both CVD and cancer, highlighting the major epidemiological studies and potential biological mechanisms that account for them. © 2016 American Heart Association, Inc.

Major osteoporotic fragility fractures: Risk factor updates and societal impact

PubMed Central

Pisani, Paola; Renna, Maria Daniela; Conversano, Francesco; Casciaro, Ernesto; Di Paola, Marco; Quarta, Eugenio; Muratore, Maurizio; Casciaro, Sergio

2016-01-01

Osteoporosis is a silent disease without any evidence of disease until a fracture occurs. Approximately 200 million people in the world are affected by osteoporosis and 8.9 million fractures occur each year worldwide. Fractures of the hip are a major public health burden, by means of both social cost and health condition of the elderly because these fractures are one of the main causes of morbidity, impairment, decreased quality of life and mortality in women and men. The aim of this review is to analyze the most important factors related to the enormous impact of osteoporotic fractures on population. Among the most common risk factors, low body mass index; history of fragility fracture, environmental risk, early menopause, smoking, lack of vitamin D, endocrine disorders (for example insulin-dependent diabetes mellitus), use of glucocorticoids, excessive alcohol intake, immobility and others represented the main clinical risk factors associated with augmented risk of fragility fracture. The increasing trend of osteoporosis is accompanied by an underutilization of the available preventive strategies and only a small number of patients at high fracture risk are recognized and successively referred for therapy. This report provides analytic evidences to assess the best practices in osteoporosis management and indications for the adoption of a correct healthcare strategy to significantly reduce the osteoporosis burden. Early diagnosis is the key to resize the impact of osteoporosis on healthcare system. In this context, attention must be focused on the identification of high fracture risk among osteoporotic patients. It is necessary to increase national awareness campaigns across countries in order to reduce the osteoporotic fractures incidence. PMID:27004165

An example of fisheries oceanography: Walleye pollock in Alaskan waters

NASA Astrophysics Data System (ADS)

Schumacher, Jim; Kendall, Arthur W.

1995-07-01

A major area of research in fisheries oceanography examines relationships between recruitment dynamics of fish populations and the marine environment. A primary goal is to understand the natural causes of variability in year-class strength of commercially valuable species and apply this knowledge to management [Perry, 1994]. The paradigm that the majority of mortality occurs during transport of early life history stages from spawning to nursery grounds [Rothschild, 1986; Houde, 1987] provides an initial temporal focus for most research. The spatial domain includes the region occupied by early life history stages. Since global climate variability impacts regional ecosystem dynamics, however, the spatial domain often must be expanded. The relative importance and manifestation of biological factors [starvation and predation] that limit survival varies each year. Marked interannual and longer period variations in temperature (an influence on metabolic rates and behavior), transport of planktonic stages, and turbulence can exert an influence on both survival of early life history stages, and distribution of juveniles and adults. To understand how these environmental factors influence reproductive success of fish stocks also requires knowledge of the impact of these factors on predators and prey throughout the food web.

Lessons regarding the safety of orthopaedic patient care: an analysis of four hundred and sixty-four closed malpractice claims.

PubMed

Matsen, Frederick A; Stephens, Linda; Jette, Jocelyn L; Warme, Winston J; Posner, Karen L

2013-02-20

An orthopaedic malpractice claim alleges that the patient sustained a preventable iatrogenic injury. The analysis of a representative series of malpractice claims provides a unique view of alleged orthopaedic adverse events, revealing what can potentially go wrong across a spectrum of practice settings and anatomic locations. The goal of this study was to identify high-impact targets in order to institute measures to reduce claims through efforts focused on patient safety. The authors investigated 464 consecutive closed malpractice claims from the nation's largest insurer of medical liability. We analyzed the claims by anatomical site, type of care rendered, type of allegation, and payment. We calculated an "impact factor" for each claim type by dividing the percentage of total payments for each type by the percentage of total claims for that type. Our analysis revealed major concerns regarding patient safety within this series of malpractice claims. One-third of the claims alleged permanent disabling injuries, including amputations, brain damage, and major nerve damage. The highest impact allegations were failure to protect structures in the surgical field (41% of total payments to plaintiffs, 15% of all claims, impact factor of 2.7) and failure to prevent, diagnose, and/or treat complications of treatment (16% of total payments, 7% of all claims, impact factor of 2.3). Spine procedures had high impact (1.9), representing 28% of dollars paid and 15% of claims, with 45% of spine claims involving death or severe permanent injury. Failure of implant positioning was commonly alleged in hip and knee arthroplasty. In claims related to fracture care, the most common allegations were related to malunions, nonunions, dislocations, failure to protect structures in the surgical field, infection, and treatment complications. Total payment for the eighty-eight claims paid was $17,917,614 (U.S. dollars adjusted to 2009). Regarding clinical relevance, this analysis suggests risk areas for targeted efforts to improve patient safety and reduce malpractice claims.

Factors influencing export of dissolved inorganic nitrogen by major rivers: A new seasonal, global-scale model

EPA Science Inventory

Understanding sub-annual patterns of catchment dissolved inorganic nitrogen (DIN) export is critical for predicting and mitigating impacts of coastal eutrophication, such as algal blooms and hypoxic areas, which are often seasonal phenomena. We developed the first calibrated glob...

Impact of sleeper berth usage on commercial driver fatigue : task 1

DOT National Transportation Integrated Search

1999-11-01

Driver fatigue is recognized as a major factor in the safety of long-haul commercial driving. Sleeper berths are often provided on tractors to allow the driver to sleep and rest when not driving. However, the sleeper berth environment and/or the mann...

Psychosocial Factors Impacting STEM Career Selection

ERIC Educational Resources Information Center

Lamb, Richard; Annetta, Leonard; Vallett, David; Firestone, Jonah; Schmitter-Edgecombe, Maureen; Walker, Heather; Deviller, Nicole; Hoston, Douglas

2018-01-01

Attention on P-20 science, technology, engineering, and mathematics (STEM) education has increased tremendously in recent years. Many efforts are underway to promote STEM major and career selection across the nation; specifically, in engineering and computer science. The authors' purpose was to examine an underlying profile combinations of latent…

Challenges of urban planning in Palestine

NASA Astrophysics Data System (ADS)

Moghayer, Taher J. T.; Tesmamma Daget, Yidnekachew; Wang, Xingping

2017-08-01

For the last two centuries, Palestinian territory had faced several changes. This is due to historical precedents and the unstable political situation in the area. This has resulted in mutli-faced challenges in Palestine. The objective of this paper is to analyse and understand the major factors that had impacted the urban planning, urban form and urban development of the Palestinian territory. The findings showed that the lack of available land, rapid urban population growth, failure in urban planning policy decisions, the unstable political situation on the ground, fragmented urban developments in the west bank area, and also diffusion of urban sprawls within the landscapes and around the cities are the major factors that caused challenges in Palestine’s cities.

Assessment of light extinction at a European polluted urban area during wintertime: Impact of PM1 composition and sources.

PubMed

Vecchi, R; Bernardoni, V; Valentini, S; Piazzalunga, A; Fermo, P; Valli, G

2018-02-01

In this paper, results from receptor modelling performed on a well-characterised PM 1 dataset were combined to chemical light extinction data (b ext ) with the aim of assessing the impact of different PM 1 components and sources on light extinction and visibility at a European polluted urban area. It is noteworthy that, at the state of the art, there are still very few papers estimating the impact of different emission sources on light extinction as we present here, although being among the major environmental challenges at many polluted areas. Following the concept of the well-known IMPROVE algorithm, here a tailored site-specific approach (recently developed by our group) was applied to assess chemical light extinction due to PM 1 components and major sources. PM 1 samples collected separately during daytime and nighttime at the urban area of Milan (Italy) were chemically characterised for elements, major ions, elemental and organic carbon, and levoglucosan. Chemical light extinction was estimated and results showed that at the investigated urban site it is heavily impacted by ammonium nitrate and organic matter. Receptor modelling (i.e. Positive Matrix Factorization, EPA-PMF 5.0) was effective to obtain source apportionment; the most reliable solution was found with 7 factors which were tentatively assigned to nitrates, sulphates, wood burning, traffic, industry, fine dust, and a Pb-rich source. The apportionment of aerosol light extinction (b ext,aer ) according to resolved sources showed that considering all samples together nitrate contributed at most (on average 41.6%), followed by sulphate, traffic, and wood burning accounting for 18.3%, 17.8% and 12.4%, respectively. Copyright © 2017 Elsevier Ltd. All rights reserved.

[Impacts of hydroelectric cascade exploitation on river ecosystem and landscape: a review].

PubMed

Yang, Kun; Deng, Xi; Li, Xue-Ling; Wen, Ping

2011-05-01

Hydroelectric cascade exploitation, one of the major ways for exploiting water resources and developing hydropower, not only satisfies the needs of various national economic sectors, but also promotes the socio-economic sustainable development of river basin. unavoidable anthropogenic impacts on the entire basin ecosystem. Based on the process of hydroelectric cascade exploitation and the ecological characteristics of river basins, this paper reviewed the major impacts of hydroelectric cascade exploitation on dam-area ecosystems, river reservoirs micro-climate, riparian ecosystems, river aquatic ecosystems, wetlands, and river landscapes. Some prospects for future research were offered, e.g., strengthening the research of chain reactions and cumulative effects of ecological factors affected by hydroelectric cascade exploitation, intensifying the study of positive and negative ecological effects under the dam networks and their joint operations, and improving the research of successional development and stability of basin ecosystems at different temporal and spatial scales.

Vulnerability of community businesses to environmental disasters.

PubMed

Zhang, Yang; Lindell, Michael K; Prater, Carla S

2009-03-01

Business plays important roles in community functioning. However, disaster research has been disproportionately focused on units of analysis such as families, households and government agencies. This paper synthesises the major findings within the business development research field and the disaster research field. It constructs a framework for evaluating business vulnerability to natural disasters. Our theoretical integration of the research conducted to date addresses five major issues. First, it defines the ways in which businesses are subject to the impacts of natural disasters. Second, it identifies the factors that determine the magnitude of business impacts after a disaster. Third, it identifies how and when businesses return to their pre-disaster level in the disaster stricken community. Fourth, it describes measures that can be taken by individual firms and community planners to reduce the impacts of environmental disasters. Fifth, it identifies needs for public policy and future research to reduce business vulnerability to environmental disasters.

Social and economic aspects of aquatic animal health.

PubMed

Adam, K E; Gunn, G J

2017-04-01

Aquaculture is an increasingly important source of animal protein for a growing global population. Disease is a major constraint to production, with resultant socio-economic impacts for individuals, communities and economies which rely on aquaculture. Aquatic animal health is also strongly influenced by human factors, ranging from international trade regulations to the behaviours of individuals working in aquaculture. This article summarises the human factors associated with aquaculture production using international examples for illustration.

Lifestyle causes of male infertility.

PubMed

Durairajanayagam, Damayanthi

2018-03-01

To examine the potential effects of lifestyle factors on male reproductive health. Evidence of a global decline in human sperm quality over recent decades has been accumulating. Environmental, occupational, and modifiable lifestyle factors may contribute to this decline. This review focuses on key lifestyle factors that are associated with male infertility such as smoking cigarettes, alcohol intake, use of illicit drugs, obesity, psychological stress, advanced paternal age, dietary practices, and coffee consumption. Other factors such as testicular heat stress, intense cycling training, lack of sleep and exposure to electromagnetic radiation from mobile phone use are briefly discussed. A comprehensive literature search was performed to identify and synthesise all relevant information, mainly from within the last decade, on the major lifestyle factors associated with male infertility and semen quality. Database searches were limited to reports published in English only. A manual search of bibliographies of the reports retrieved was conducted to identify additional relevant articles. In all, 1012 articles were identified from the database search and after reviewing the titles and abstract of the reports, 104 articles met the inclusion criteria. Of these, 30 reports were excluded as the full-text could not be retrieved and the abstract did not have relevant data. The remaining 74 reports were reviewed for data on association between a particular lifestyle factor and male infertility and were included in the present review. The major lifestyle factors discussed in the present review are amongst the multiple potential risk factors that could impair male fertility. However, their negative impact may well be mostly overcome by behaviour modification and better lifestyle choices. Greater awareness and recognition of the possible impact of these lifestyle factors are important amongst couples seeking conception.

Species distribution models and impact factor growth in environmental journals: methodological fashion or the attraction of global change science.

PubMed

Brotons, Lluís

2014-01-01

In this work, I evaluate the impact of species distribution models (SDMs) on the current status of environmental and ecological journals by asking the question to which degree development of SDMs in the literature is related to recent changes in the impact factors of ecological journals. The hypothesis evaluated states that research fronts are likely to attract research attention and potentially drive citation patterns, with journals concentrating papers related to the research front receiving more attention and benefiting from faster increases in their impact on the ecological literature. My results indicate a positive relationship between the number of SDM related articles published in a journal and its impact factor (IF) growth during the period 2000-09. However, the percentage of SDM related papers in a journal was strongly and positively associated with the percentage of papers on climate change and statistical issues. The results support the hypothesis that global change science has been critical in the development of SDMs and that interest in climate change research in particular, rather than the usage of SDM per se, appears as an important factor behind journal IF increases in ecology and environmental sciences. Finally, our results on SDM application in global change science support the view that scientific interest rather than methodological fashion appears to be the major driver of research attraction in the scientific literature.

Parental Reports of Children's Post-Divorce Adjustment.

ERIC Educational Resources Information Center

Fulton, Julie A.

1979-01-01

Two years after the final decree, 560 divorced parents were asked to assess the impact of the divorce on their children. Factors associated with fathers' responses differed from those associated with mothers', but the majority of each group felt that their children had been negatively affected by the divorce. (Author/GC)

The impact of weather conditions on response of sorghum genotypes to anthracnose (Colletotrichum sublineola) infection

USDA-ARS?s Scientific Manuscript database

Rainfall is a major climatic factor influencing anthracnose development and in this study, 68 sorghum accessions were evaluated for anthracnose resistance under dry and wet growing conditions at the Texas A&M Agricultural Experiment Station, near College Station, Texas. Accessions, planted in a ran...

Economic Implications of Japan's Ageing Population: A Macro-economic Demographic Modelling Approach.

ERIC Educational Resources Information Center

Ogawa, Naohiro

1982-01-01

This study discusses the impact of the aging of the Japanese population upon various socioeconomic factors. Major findings are that the rate of real gross national product growth will decline continuously and that more financial resources will be required for government social security programs. (Editor/CT)

In Celebration of Nature: A Dialogue with Jerome Kagan.

ERIC Educational Resources Information Center

Ellis, Michael V.; Robbins, Erica S.

1990-01-01

Presents interview with Jerome Kagan who has studied the role of biology as a major determinant of human behavior for more than three decades. Claims results of this research have had significant impact on the field of developmental psychology and on understanding of temperamental factors. (Author/ABL)

76 FR 5192 - BOEMRE Information Collection Activity: 1010-0170-Coastal Impact Assistance Program (CIAP...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-28

... disclose this information, you should comment and provide your total capital and startup cost components or... use to estimate major cost factors, including system and technology acquisition, expected useful life... startup costs include, among other items, computers and software you purchase to prepare for collecting...

What's on the Horizon? Trends Impacting Higher Education.

ERIC Educational Resources Information Center

Corey, Del; And Others

Major national trends and their effects on the future of education are examined. Demographic events that affected schools include the postwar baby boom and the migration from the Northeast to the sunbelt region. Factors affecting the college curriculum include: (1) enrollment projections, (2) decline in literacy, (3) decline in mathematics and…

Factors Impacting Principals' Career Decision Making

ERIC Educational Resources Information Center

Sorapuru, Wylene M.

2012-01-01

Federal legislation and educational programs such as "No Child Left Behind" (2001) and "Race to the Top" (2009) identify school leaders as one of the major catalysts to improving academic achievement. Increasing accountability demands call for replacement of the principal when adequate gains in student achievement are not met,…

Responding to Critical Pedagogy: Marginalized Students and the College Classroom

ERIC Educational Resources Information Center

Mencke, Paul D.

2010-01-01

Marginalized college students are retained at disproportional rates than their counterparts. A major factor of retention is student engagement in the classroom, which can be impacted by course design and instruction. Critical pedagogy aims to value all students' experiences through six elements of course design and instruction: decreasing teacher…

Employees on the Move!

ERIC Educational Resources Information Center

Levin, Sarah

This paper describes a method for designing, implementing, and evaluating a work-site physical activity campaign aimed at employees who are currently sedentary in their leisure time. Inactivity is a major but modifiable risk factor for coronary heart disease. Increasing the activity levels of underactive adults would have a positive impact on…

Allocating Retirement Funds between TIAA and CREF: How Should Participants Choose Now between Fixed and Variable Annuities?

ERIC Educational Resources Information Center

Malkiel, Burton G.

1979-01-01

The basic provisions of the TIAA-CREF retirement plans are outlined and the impact of inflation and falling stock prices on annuities and bonds are investigated. Major factors that should be considered when allocating contributions to TIAA-CREF funds are discussed. (SF)

Reflections on a Seminal Force in International Accounting

ERIC Educational Resources Information Center

Cascini, Karen T.

2007-01-01

Accounting is a manifestation of several important environmental factors within a country, including economic, educational and political, and, as such, is evolutionary in accordance with those changing social structures. Because of the major impact that international accounting has had on countries' internal accounting systems, it is important to…

Teacher Competencies through the Prism of Educational Research

ERIC Educational Resources Information Center

Peklaj, Cirila

2015-01-01

The present article focuses on teacher competencies as a major factor that impacts student learning. Ultimately, all attempts to improve education converge in the teacher and the quality of his/her work with students. With their teaching methods, their communication and their classroom management, teachers can structure the kind of learning…

Overexpression of SbMyb60 impacts phenylpropanoid biosynthesis and alters secondary cell wall composition in sorghum bicolor

USDA-ARS?s Scientific Manuscript database

The phenylpropanoid biosynthesis pathway that generates lignin subunits represents a significant target to alter the abundance and composition of lignin. The major regulators of phenylpropanoid metabolism are myb transcription factors, which have been shown to modulate secondary cell wall compositi...

Impacts of anaerobic soil disinfestation and chemical fumigation on soil microbial communities in field tomato production system

USDA-ARS?s Scientific Manuscript database

Anaerobic soil disinfestation (ASD), a potential alternative to chemical fumigation for controlling soilborne pathogens, has been demonstrated in several agricultural production systems. Soil microbial community as affected by ASD is considered one of the major factors responsible for pathogen suppr...

Evaluation: An Imperative for Public Education and Training Programs. Professorial Inaugural Lecture Series.

ERIC Educational Resources Information Center

McCaslin, N. L.

Evaluation is important to public education and training programs if the United States is to be competitive in a global economy. Six major factors have had an impact on evaluation efforts: decreased financial resources, increased public dissatisfaction, changed management approaches, enhanced evaluation methods and procedures, redesigned…

Epidemiology of impaction colic in donkeys in the UK

PubMed Central

Cox, Ruth; Proudman, Christopher J; Trawford, Andrew F; Burden, Faith; Pinchbeck, Gina L

2007-01-01

Background Colic (abdominal pain) is a clinical condition of serious concern affecting the welfare and survival of donkeys at the Donkey Sanctuary in the UK. One of the most commonly reported causes is due to impacted ingesta in the large intestine ("impaction colic"). However little is known about the incidence of, or risk factors for, this condition. Here we describe the epidemiology of colic in donkeys, specifically impaction colic. We focus on temporal aspects of the disease and we identify environmental and management related risk factors for impaction colic in UK donkeys. Results There were 807 colic episodes in the population of 4596 donkeys between January 1st 2000 and March 31st 2005. The majority (54.8%) of episodes were due to a suspected or confirmed diagnosis of impaction of the gastrointestinal tract. The mortality risk for all colics (51.1%) was higher than reported in other equids. The incidence rate of all colics (5.9 episodes per 100 donkeys per year) and of impaction colic (3.2 episodes) was similar to that in horses. A retrospective matched case-control study of all impaction colics from January 2003 (193) indicated that older donkeys, those fed extra rations and those that previously suffered colic were at increased risk of impaction. Lighter body weight, musculo-skeletal problems, farm and dental disease were also significantly associated with a diagnosis of impaction colic. Conclusion To our knowledge this is the first study to estimate the incidence rate of colic in a large population of donkeys in the UK. In contrast to other equids, impaction was the most commonly reported cause of colic. We identified several risk factors for impaction colic. Increasing age, extra rations and previous colic are known risk factors for colic in other equids. Results support the hypothesis that dental disease is associated with impaction colic. Musculo-skeletal problems may be associated with colic for various reasons including change in amount of exercise or time at pasture. Other associated factors (weight and farm) are the subject of further research. Identification of risk factors for impaction colic may highlight high risk donkeys and may allow intervention strategies to be introduced to reduce the incidence of the disease. PMID:17274808

Impact of Stone Removal on Renal Function: A Review

PubMed Central

Wood, Kyle; Keys, Tristan; Mufarrij, Patrick; Assimos, Dean G

2011-01-01

Stone removal can improve renal function by eradicating obstruction and, in certain cases, an underlying infection. Stone-removing procedures, however, may negatively impact functional integrity. Many things may impact the latter, including the procedures used, the methods of assessing function, the time when these assessments are made, the occurrence of complications, the baseline condition of the kidney, and patient-related factors. In the majority of cases, little significant functional impairment occurs. However, there are gaps in our knowledge of this subject, including the cumulative effects of multiple procedures violating the renal parenchyma and long-term functional outcomes. PMID:21935339

Project IMPACT: a report on barriers and facilitators to sustainability.

PubMed

Blasinsky, Margaret; Goldman, Howard H; Unützer, Jürgen

2006-11-01

Project IMPACT is a collaborative care intervention to assist older adults suffering from major depressive disorder or dysthymia. Qualitative research methods were used to determine the barriers and facilitators to sustaining IMPACT in a primary care setting. Strong evidence supports the program's sustainability, but considerable variation exists in continuation strategies and operationalization across sites. Sustainability depended on the organizations' support of collaborative care models, the availability of staff trained in the intervention, and funding. The intervention's success was the most important sustainability factor, as documented by outcome data and through the "real world" experience of treating patients with this intervention.

Understanding how seasonality and shifts in species composition impact emission estimates in semi-arid ecosystems

NASA Astrophysics Data System (ADS)

Sparks, A. M.; Yokelson, R. J.; Smith, A. M.; Marshall, J. D.; Tinkham, W.

2013-12-01

The importance of wildland fire as a source of trace gas emissions to the atmosphere has been demonstrated in the scientific literature and through numerous NASA funded campaigns to further understand the drivers and impacts of these emissions (e.g., SAFARI 1992, SAFARI 2000, TRACE A, etc). Most studies quantify emissions using remotely sensed data through multiplying the area burned, the quantity of fuel combusted, and the emission factors of a given gas species (EFX, grams of gas, X, emitted per kilogram of fuel consumed). The latter is known to exhibit considerable uncertainty and indeed a prior study as part of NASA's SAFARI 2000 campaign highlighted a seasonal dependence of carbonaceous gas species emissions. In this study, rangeland grass and shrub species were collected periodically from northern Great Basin shrub-steppe ecosystems during the typical burn season and burned in a small-scale laboratory setup where major carbonaceous and nitrogenous emission species were monitored and measured. Preliminary results indicate that emission factors of several major gas species, including carbon monoxide and nitrogen oxides, vary considerably over the course of a season. Large differences in emission apportionment between the rangeland species also suggests that shifting vegetation composition (via replacement of native with invasive species) can have a significant influence on emissions from semi-arid ecosystems. Further development of this data could lead to an enhanced understanding of how emission factors vary seasonally and how total emissions change with major vegetation shifts in other ecosystems.

The unexplored relationship between the urinary tract infections and the autonomic nervous system

PubMed Central

Hibbing, Michael E.; Conover, Matt S.; Hultgren, Scott J.

2015-01-01

Urinary tract infections (UTIs), the majority of which are caused by uropathogenic E. coli (UPEC), are extremely common infections that preferentially effect women. Additional complicating factors, such as catheterization, diabetes, and spinal cord injuries can increase the frequency and severity of UTIs. The rise of antimicrobial resistant uropathogens and the ability of this disease to chronically recur make the development of alternative preventative and therapeutic modalities a priority. The major symptoms of UTIs, urgency, frequency, and dysuria, are readouts of the autonomic nervous system (ANS) and the majority of the factors that lead to complicated UTIs have been shown to impact ANS function. This review summarizes the decades long efforts to understand the molecular mechanisms of the interactions between UPEC and the host, with a particular focus on the recent findings revealing the molecular, bacteriological, immunological and epidemiological complexity of pathogenesis. Additionally, we describe the progress that has been made in: i) generating vaccines and anti-virulence compounds that prevent and/or treat UTI by blocking bacterial adherence to urinary tract tissue and; ii) elucidating the mechanism by which anti-inflammatories are able to alleviate symptoms and improve disease prognosis. Finally, the potential relationships between the ANS and UTI are considered throughout. While these relationships have not been experimentally explored, the known interactions between numerous UTI characteristics (symptoms, complicating factors, and inflammation) and ANS function suggest that UTIs are directly impacting ANS stimulation and that ANS (dys)function may alter UTI prognosis. PMID:26108548

Stop hitting yourself: did most terrestrial impactors originate from the terrestrial planets?

NASA Astrophysics Data System (ADS)

Jackson, Alan; Asphaug, Erik; Elkins-Tanton, Linda

2014-11-01

Although the asteroid belt is the main source of impactors in the inner solar system today, it contains only 0.0006 Earth mass, or 0.05 Lunar mass. While the asteroid belt would have been more massive when it formed, it is unlikely to have had greater than 0.5 Lunar mass since the formation of Jupiter and the dissipation of the solar nebula. By comparison, giant impacts onto the terrestrial planets typically release debris equal to several per cent of the planets mass. The Moon-forming impact on Earth and the dichotomy forming impact on Mars, to consider but two of these major events, released 1.3 and 0.3 Lunar mass in debris respectively, many times the mass of the present day asteroid belt. This escaping impact debris is less long lived than the main asteroid belt, as it is injected on unstable, planet-crossing orbits, but this same factor also increases the impact probability with the terrestrial planets and asteroids. We show that as a result terrestrial ejecta played a major role in the impact history of the early inner solar system, and we expect the same is also likely to be true in other planetary systems.

EEG alpha power as an intermediate measure between brain-derived neurotrophic factor Val66Met and depression severity in patients with major depressive disorder.

PubMed

Zoon, Harriët F A; Veth, C P M; Arns, Martijn; Drinkenburg, W H I M; Talloen, Willem; Peeters, Pieter J; Kenemans, J L

2013-06-01

Major depressive disorder has a large impact on patients and society and is projected to be the second greatest global burden of disease by 2020. The brain-derived neurotrophic factor (BDNF) gene is considered to be one of the important factors in the etiology of major depressive disorder. In a recent study, alpha power was found to mediate between BDNF Met and subclinical depressed mood. The current study looked at a population of patients with major depressive disorder (N = 107) to examine the association between the BDNF Val66Met polymorphism, resting state EEG alpha power, and depression severity. For this purpose, repeated-measures analysis of variance, partial correlation, and multiple linear models were used. Results indicated a negative association between parietal-occipital alpha power in the eyes open resting state and depression severity. In addition, Met/Met patients showed lower global absolute alpha power in the eyes closed condition compared with Val-carriers. These findings are in accordance with the previously uncovered pathway between BDNF Val66Met, resting state EEG alpha power, and depression severity. Additional research is needed for the clarification of this tentative pathway and its implication in personalized treatment of major depressive disorder.

Skin cancer in the elderly

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pollack, S.V.

Skin cancer is a major concern in geriatric populations. Cumulative exposure to carcinogens and age-related factors both contribute to the high prevalence of cutaneous malignancy in the elderly. Although mortality rates from skin cancer are relatively low, morbidity can be significant, particularly if lesions are neglected. Physicians can have a major impact on the course of basal cell carcinoma, squamous cell carcinoma, and malignant melanoma by nurturing a high index of suspicion for malignancy when unexplained cutaneous lesions are encountered. 56 references.

Increasing age is a major risk factor for susceptibility to heat stress during physical activity.

PubMed

McGinn, Ryan; Poirier, Martin P; Louie, Jeffrey C; Sigal, Ronald J; Boulay, Pierre; Flouris, Andreas D; Kenny, Glen P

2017-11-01

We evaluated the extent to which age, cardiorespiratory fitness, and body fat can independently determine whole-body heat loss (WBHL) in 87 otherwise healthy adults. We show that increasing age is a major predictor for decreasing WBHL in otherwise healthy adults (aged 20-70 years), accounting for 40% of the variation in the largest study to date. While greater body fat also had a minor detrimental impact on WBHL, there was no significant role for cardiorespiratory fitness.

Circulating species of Leishmania at microclimate area of Boulemane Province, Morocco: impact of environmental and human factors.

PubMed

Hmamouch, Asmae; El Alem, Mahmoud Mohamed; Hakkour, Maryam; Amarir, Fatima; Daghbach, Hassan; Habbari, Khalid; Fellah, Hajiba; Bekhti, Khadija; Sebti, Faiza

2017-02-22

Cutaneous leishmaniasis (CL) is widely distributed in Morocco where its geographical range and incidence are related to environmental factors. This study aimed to examine the impact of several factors on the distribution of CL in Boulemane Province, which is characterized by several microclimates, and to identify the Leishmania species circulating in these areas. Ordinary least squares regression (OLSR) analysis was performed to study the impact of poverty, vulnerability, population density, urbanization and bioclimatic factors on the distribution of CL in this province. Molecular characterization of parasites was performed using a previously described PCR-RFLP method targeting the ITS1 of ribosomal DNA of Leishmania. A total of 1009 cases were declared in Boulemane Province between the years 2000 and 2015 with incidences fluctuating over the years (P = 0.007). Analyzing geographical maps of the study region identified four unique microclimate areas; sub-humid, semi-arid, arid and Saharan. The geographical distribution and molecular identification of species shows that the Saharan microclimate, characterized by the presence of Leishmania major was the most affected (47.78%) followed by semi-arid area where Leishmania tropica was identified in three districts. Among several environmental factors included in the study, poverty had the greatest influence on the spatial extension of the disease in this province. The incidence of CL in Boulemane Province varies between microclimate areas, and environmental factors partly explain this variation. However, the existence of CL in the most affected districts is mainly related to poverty, population movement and human behavior. To our knowledge, this the first study utilizing molecular techniques to confirm L. tropica and L. major as the causative agents of CL in Boulemane Province. Our findings indicate that the spatial and temporal distribution of CL in Boulemane Province is strongly related to poverty and population movement.

Assessment of hydrogeochemical status of groundwater in a coastal region of Southeast coast of India

NASA Astrophysics Data System (ADS)

Chidambaram, S.; Sarathidasan, J.; Srinivasamoorthy, K.; Thivya, C.; Thilagavathi, R.; Prasanna, M. V.; Singaraja, C.; Nepolian, M.

2018-03-01

A study was conducted in a coastal region of Cuddalore district of Tamil Nadu, India, to identify the hydrogeochemical processes controlling the groundwater chemistry. The major geological units of the study area are sandstone, clay, alluvium, and laterite soils of Tertiary and Quaternary age. A total of 64 groundwater samples were measured for major ions and stable isotopes. Higher electrical conductivity values indicate the poor quality groundwater along the coastal region. Saline water intrusion mainly affects the hydrochemical composition of the aquifer water reflected by Na-Cl-type waters. Cl-/(Cl- + HCO3 -) ratio also indicates the mixing of fresh groundwater with saline water. The results of δD and δ18O analyses show that isotopic compositions of groundwater ranges from - 7.7 to - 2.1‰ for δ18O and from - 55.6 to - 18.5‰ for δD. Correlation and factor analysis were carried out to find the association of ions and to determine the major factors controlling the groundwater chemistry of the region. The study indicates that ion exchange, weathering, salt water intrusion along the coast, and anthropogenic impacts are the major controlling factors for the groundwater chemistry of the region.

Assessment of neurogenic bowel dysfunction impact after spinal cord injury using the International Classification of Functioning, Disability and Health.

PubMed

Pires, Jennifer M; Ferreira, Ana M; Rocha, Filipa; Andrade, Luis G; Campos, Inês; Margalho, Paulo; Laíns, Jorge

2018-05-09

Bowel function is frequently compromised after spinal cord injury (SCI). Regardless of this crucial importance in patients' lives, there is still scarce literature on the Neurogenic Bowel Dysfunction (NBD) deleterious impact on SCI patient's lives and only few studies correlating NBD severity with quality of life (QoL). To our knowledge there are no studies assessing the impact of NBD on the context of ICF domains. To assess NBD after SCI using ICF domains and to assess its impact in QoL. Retrospective data analysis and cross-sectional phone survey. Outpatient spinal cord injury setting. Portuguese adult spinal cord injury patients. Retrospective analysis of demographic data, lesion characteristics and bowel management methods at last inpatient discharge. Cross-sectional phone survey assessing current bowel management methods, the Neurogenic Bowel Dysfunction Score and a Likert scale questionnaire about the impact on ICF domains and QoL. 64 patients answered the questionnaire. The majority was male (65.6%), mean age 56.6±15.6 years, AIS A lesion (39.1%), with a traumatic cause (71.9%). The main bowel management methods were contact laxatives, suppositories and osmotic laxatives. 50.1% of patients scored moderate or severe NBD. Considering ICF domains, the greatest impact was in personal and environmental factors, with 39.1% reporting impact in financial costs, 45.3% in need of assistance, 45.3% in emotional health and 46.9% in loss of privacy. There was a significant association between severity of NBD and negative impact on QoL (p<0.05). The study confirms the major impact of NBD on personal and environmental factors of ICF and on the quality of life of SCI population. These findings confirm that it is relevant to identify the main ICF domains affected by NBD after SCI in order to address targeted interventions, working toward changes in health policies and psychosocial aspects.

Positive and negative psychological impact after secondary exposure to politically motivated violence among body handlers and rehabilitation workers.

PubMed

Shiri, Shimon; Wexler, Isaiah D; Alkalay, Yasmin; Meiner, Zeev; Kreitler, Shulamith

2008-12-01

The positive and negative psychological impact of secondary exposure to politically motivated violence was examined among body handlers and hospital rehabilitation workers, 2 groups that differed in their proximity and immediacy to violent events. Survivors of politically motivated violence served as a comparison group. Body handlers experienced high levels of positive psychological impact and traumatic stress symptoms. Levels of positive psychological impact among on-scene body handlers were higher than those experienced by rehabilitation workers. Traumatic stress symptoms predicted positive psychological impact among body handlers. These findings indicate that proximity to stressors is associated with higher levels of positive and negative psychological impact. Physical proximity is a major contributory factor to both positive and negative psychological effects of secondary exposure to trauma.

[Analysis of academic impact of publications from National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention based on SCIE database in recent five years].

PubMed

Zhen, Li; Bin, Zheng

2017-03-02

To describe the academic impact of publications from National Institute of Parasitic Diseases (NIPD), Chinese Center for Disease Control and Prevention, so as to give the quantity evidence for scientific research decision making. The SCIE papers of NIPD published from 2011-2015 were searched and statistically analyzed. The number of published papers, citation frequencies, h-index, and funding resources were analyzed. The academic impact of the institute was assessed according to these data. A total of 361 papers were published by NIPD, and the quantity increased year by year. The majority type is original articles. The total citations were 1 641 times, the average citation per paper was 5.19 and h-index was 17. The majority of these papers were published in foreign professional periodicals, whose impact factors were between 1.194 and 6.751. The major resources of NIPD were from China, and NIPD also had good collaborations with institutions in US and Switzerland. In China and Asia, NIPD led the research in the field of parasitology and tropical medicine. The quantity and quality of annual published papers of NIPD are on the rise. However, NIPD lagged behind the leading institutions in the world.

Conflicts of Interest at Medical Journals: The Influence of Industry-Supported Randomised Trials on Journal Impact Factors and Revenue – Cohort Study

PubMed Central

Lundh, Andreas; Barbateskovic, Marija; Hróbjartsson, Asbjørn; Gøtzsche, Peter C.

2010-01-01

Background Transparency in reporting of conflict of interest is an increasingly important aspect of publication in medical journals. Publication of large industry-supported trials may generate many citations and journal income through reprint sales and thereby be a source of conflicts of interest for journals. We investigated industry-supported trials' influence on journal impact factors and revenue. Methods and Findings We sampled six major medical journals (Annals of Internal Medicine, Archives of Internal Medicine, BMJ, JAMA, The Lancet, and New England Journal of Medicine [NEJM]). For each journal, we identified randomised trials published in 1996–1997 and 2005–2006 using PubMed, and categorized the type of financial support. Using Web of Science, we investigated citations of industry-supported trials and the influence on journal impact factors over a ten-year period. We contacted journal editors and retrieved tax information on income from industry sources. The proportion of trials with sole industry support varied between journals, from 7% in BMJ to 32% in NEJM in 2005–2006. Industry-supported trials were more frequently cited than trials with other types of support, and omitting them from the impact factor calculation decreased journal impact factors. The decrease varied considerably between journals, with 1% for BMJ to 15% for NEJM in 2007. For the two journals disclosing data, income from the sales of reprints contributed to 3% and 41% of the total income for BMJ and The Lancet in 2005–2006. Conclusions Publication of industry-supported trials was associated with an increase in journal impact factors. Sales of reprints may provide a substantial income. We suggest that journals disclose financial information in the same way that they require them from their authors, so that readers can assess the potential effect of different types of papers on journals' revenue and impact. Please see later in the article for the Editors' Summary PMID:21048986

Conflicts of interest at medical journals: the influence of industry-supported randomised trials on journal impact factors and revenue - cohort study.

PubMed

Lundh, Andreas; Barbateskovic, Marija; Hróbjartsson, Asbjørn; Gøtzsche, Peter C

2010-10-26

transparency in reporting of conflict of interest is an increasingly important aspect of publication in medical journals. Publication of large industry-supported trials may generate many citations and journal income through reprint sales and thereby be a source of conflicts of interest for journals. We investigated industry-supported trials' influence on journal impact factors and revenue. we sampled six major medical journals (Annals of Internal Medicine, Archives of Internal Medicine, BMJ, JAMA, The Lancet, and New England Journal of Medicine [NEJM]). For each journal, we identified randomised trials published in 1996-1997 and 2005-2006 using PubMed, and categorized the type of financial support. Using Web of Science, we investigated citations of industry-supported trials and the influence on journal impact factors over a ten-year period. We contacted journal editors and retrieved tax information on income from industry sources. The proportion of trials with sole industry support varied between journals, from 7% in BMJ to 32% in NEJM in 2005-2006. Industry-supported trials were more frequently cited than trials with other types of support, and omitting them from the impact factor calculation decreased journal impact factors. The decrease varied considerably between journals, with 1% for BMJ to 15% for NEJM in 2007. For the two journals disclosing data, income from the sales of reprints contributed to 3% and 41% of the total income for BMJ and The Lancet in 2005-2006. publication of industry-supported trials was associated with an increase in journal impact factors. Sales of reprints may provide a substantial income. We suggest that journals disclose financial information in the same way that they require them from their authors, so that readers can assess the potential effect of different types of papers on journals' revenue and impact.

Scientific publications in public, environmental and occupational health journals by authors from China, Japan and Korea in East Asia: A 10-year literature survey from 2003 to 2012.

PubMed

Li, Meina; Liu, Xiaodong; Zhang, Lulu

2015-01-01

To compare the number and quality of public, environmental and occupational health articles published in international journals from the 3 major non-English speaking countries of East Asia: China, Japan and Korea. Public, environmental and occupational health articles from China, Japan and Korea that were published in 161 journals from 2003 to 2012 were retrieved from the Science Citation Index Expanded (SCIE) database. We recorded the numbers of total articles, impact factors (IF), citations, number of articles in top 10 journals, references as well as the article distribution from various regions in China. From 2003 to 2012, China, Japan and Korea published 5713, 3802 and 1967 papers respectively, with accumulated impact factor of 14 934.55, 8758.36 and 6189.25, the average impact factor of 2.61, 2.30 and 3.15 and the average citation numbers per document of 5.08, 6.49 and 5.25. In the top 10 high-impact public, environmental and occupational health journals, China, Japan and Korea accounted for 50.19%, 20.34% and 29.47% of all the papers published in those journals, respectively. Total impact factors of the most popular 10 papers for China, Japan and Korea were: 26.23, 27.08 and 26.91. Distribution of scientific papers among regions was unbalanced in China, for Hong Kong and Taiwan it accounted for 47.31% of the papers from China. From 2003 to 2012, both the quality and number of papers from China published in public, environmental and occupational health journals have greatly improved. China exceeded Japan and Korea in the number, accumulated impact factor, total citation times and the average number of references, while Korea had the highest average impact factor. Japan had the highest journal impact factor among the most popular journals, and the highest average citation number per document. This work is available in Open Access model and licensed under a CC BY-NC 3.0 PL license.

Is susceptibility to tuberculosis acquired or inherited?

PubMed

Schurr, E

2007-02-01

Tuberculosis is an ongoing major public health problem on a global scale. One of the striking features of the disease is that only an estimated 10% of immunocompetent persons infected by the causative pathogen Mycobacterium tuberculosis will develop clinical signs of disease. This well-established epidemiological observation has prompted an intense search for the factors that trigger advancement of infection to disease in the small proportion of susceptible individuals. Central to this search is the questions if tuberculosis patients are inherently susceptible to the disease or if disease development is promoted by specific environmental factors. It is known that genetic and non-genetic factors of both the bacterium and the host have impact on the host response to M. tuberculosis. Yet, little is known about the interaction of these different factors and the resulting impact on disease development. Recent work suggests that in addition to common host susceptibility genes a second group of susceptibility loci exists the action of which strongly depends on the individual's clinical and exposure history. The latter genes may have a very strong effect on promoting advancement from infection to disease only in specific epidemiological settings. These findings suggest that a more detailed knowledge of gene-environment interactions in tuberculosis is necessary to understand why a small proportion of individuals are susceptible to the disease whilst the majority of humans are naturally resistant to tuberculosis.

What Persons with Chronic Health Conditions Need to Maintain or Return to Work—Results of an Online-Survey in Seven European Countries

PubMed Central

Foitzek, Nicole; Ávila, Carolina C.; Ivandic, Ivana; Bitenc, Črtomir; Cabello, Maria; Gruber, Sonja; Muñoz-Murillo, Amalia; Tobiasz-Adamczyk, Beata; Vlachou, Anastasia; Esteban, Eva

2018-01-01

Chronic health conditions represent the major share of the disease burden in Europe and have a significant impact on work. This study aims to: (1) identify factors that have a negative or positive impact on the work lives of persons with chronic health conditions; (2) explore the needs of these persons to maintain a job or return to work and (3) compare these results with respect to these persons’ occupational status. An online survey was performed in seven European countries. Open-ended survey questions were analyzed using qualitative methods. In total, 487 participants with six chronic health conditions participated. The majority of participants named work-related aspects (such as career development, stress at the workplace, work structure and schedule as well as workload), support of others and attitudes of others as being the factors positively and negatively impact their work lives the most. Our study shed light on the importance of changing the attitudes of supervisors and co-workers to counteract stigmatization of persons with chronic health conditions in the workplace. In conclusion, this study provides a basis for developing new strategies of integration and reintegration at work for persons with chronic health conditions in European countries. PMID:29587433

What Persons with Chronic Health Conditions Need to Maintain or Return to Work-Results of an Online-Survey in Seven European Countries.

PubMed

Foitzek, Nicole; Ávila, Carolina C; Ivandic, Ivana; Bitenc, Črtomir; Cabello, Maria; Gruber, Sonja; Leonardi, Matilde; Muñoz-Murillo, Amalia; Scaratti, Chiara; Tobiasz-Adamczyk, Beata; Vlachou, Anastasia; Esteban, Eva; Sabariego, Carla; Coenen, Michaela

2018-03-26

Chronic health conditions represent the major share of the disease burden in Europe and have a significant impact on work. This study aims to: (1) identify factors that have a negative or positive impact on the work lives of persons with chronic health conditions; (2) explore the needs of these persons to maintain a job or return to work and (3) compare these results with respect to these persons' occupational status. An online survey was performed in seven European countries. Open-ended survey questions were analyzed using qualitative methods. In total, 487 participants with six chronic health conditions participated. The majority of participants named work-related aspects (such as career development, stress at the workplace, work structure and schedule as well as workload), support of others and attitudes of others as being the factors positively and negatively impact their work lives the most. Our study shed light on the importance of changing the attitudes of supervisors and co-workers to counteract stigmatization of persons with chronic health conditions in the workplace. In conclusion, this study provides a basis for developing new strategies of integration and reintegration at work for persons with chronic health conditions in European countries.

Soil ionomic and enzymatic responses and correlations to fertilizations amended with and without organic fertilizer in long-term experiments.

PubMed

Feng, Xumeng; Ling, Ning; Chen, Huan; Zhu, Chen; Duan, Yinghua; Peng, Chang; Yu, Guanghui; Ran, Wei; Shen, Qirong; Guo, Shiwei

2016-04-15

To investigate potential interactions between the soil ionome and enzyme activities affected by fertilization with or without organic fertilizer, soil samples were collected from four long-term experiments over China. Irrespective of variable interactions, fertilization type was the major factor impacting soil ionomic behavior and accounted for 15.14% of the overall impact. Sampling site was the major factor affecting soil enzymatic profile and accounted for 34.25% of the overall impact. The availabilities of Pb, La, Ni, Co, Fe and Al were significantly higher in soil with only chemical fertilizer than the soil with organic amendment. Most of the soil enzyme activities, including α-glucosidase activity, were significantly activated by organic amendment. Network analysis between the soil ionome and the soil enzyme activities was more complex in the organic-amended soils than in the chemical fertilized soils, whereas the network analysis among the soil ions was less complex with organic amendment. Moreover, α-glucosidase was revealed to generally harbor more corrections with the soil ionic availabilities in network. We concluded that some of the soil enzymes activated by organic input can make the soil more vigorous and stable and that the α-glucosidase revealed by this analysis might help stabilize the soil ion availability.

Soil ionomic and enzymatic responses and correlations to fertilizations amended with and without organic fertilizer in long-term experiments

PubMed Central

Feng, Xumeng; Ling, Ning; Chen, Huan; Zhu, Chen; Duan, Yinghua; Peng, Chang; Yu, Guanghui; Ran, Wei; Shen, Qirong; Guo, Shiwei

2016-01-01

To investigate potential interactions between the soil ionome and enzyme activities affected by fertilization with or without organic fertilizer, soil samples were collected from four long-term experiments over China. Irrespective of variable interactions, fertilization type was the major factor impacting soil ionomic behavior and accounted for 15.14% of the overall impact. Sampling site was the major factor affecting soil enzymatic profile and accounted for 34.25% of the overall impact. The availabilities of Pb, La, Ni, Co, Fe and Al were significantly higher in soil with only chemical fertilizer than the soil with organic amendment. Most of the soil enzyme activities, including α-glucosidase activity, were significantly activated by organic amendment. Network analysis between the soil ionome and the soil enzyme activities was more complex in the organic-amended soils than in the chemical fertilized soils, whereas the network analysis among the soil ions was less complex with organic amendment. Moreover, α-glucosidase was revealed to generally harbor more corrections with the soil ionic availabilities in network. We concluded that some of the soil enzymes activated by organic input can make the soil more vigorous and stable and that the α-glucosidase revealed by this analysis might help stabilize the soil ion availability. PMID:27079657

Impact of classical risk factors of type 2 diabetes among Asian Indian, Chinese and Japanese populations.

PubMed

He, L; Tuomilehto, J; Qiao, Q; Söderberg, S; Daimon, M; Chambers, J; Pitkäniemi, J

2015-11-01

This review investigated the population impact of major modifiable type 2 diabetes (T2D) risk factors, with special focus on native Asian Indians, to estimate population attributable risks (PARs) and compare them with estimates from Chinese and Japanese populations. Information was obtained on risk factors in 21,041 Asian Indian, 17,774 Chinese and 17,986 Japanese populations from multiple, large, cross-sectional studies (the DECODA project) of T2D. Crude and adjusted PARs were estimated for the major T2D risk factors. Age had the highest crude and adjusted PARs among Asian Indians and Chinese in contrast to waist-hip ratio among Japanese. After adjusting for age, the PAR for body mass index (BMI) in Asian Indians (41.4% [95% CI: 37.2%; 45.4%]) was second only to triglycerides (46.4% [95% CI: 39.5%; 52.8%]) compared with 35.8% [95% CI: 29.9%; 41.4%] in Japanese and 38.4% [95% CI: 33.5%; 43.2%] in Chinese people. The PAR for BMI adjusted for age, LDL and triglycerides (39.7% [95% CI: 31.6%; 47.2%]) was higher than for any other factor in Asian Indians, and was much higher than in the Chinese (16.8% [95% CI: 3.0%; 30.9%]) and Japanese (30.4% [95% CI: 17.5%; 42.2%]) populations. This review provides estimates of the association between major risk factors and prevalences of T2D among Asian populations by examining their PARs from large population-based samples. From a public-health point of view, the importance of BMI in Asian Indians is especially highlighted in comparison to the other Asian populations. Given these results and other recent findings on the causality link between BMI and T2D, it can be postulated that obesity may be involved in the aetiology of T2D through interaction with ethnic-specific genetic factors, although ethnicity itself is not a direct risk factor for T2D as people of all ethnic backgrounds develop diabetes. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

The Impact of Western Diet and Nutrients on the Microbiota and Immune Response at Mucosal Interfaces

PubMed Central

Statovci, Donjete; Aguilera, Mònica; MacSharry, John; Melgar, Silvia

2017-01-01

Recent findings point toward diet having a major impact on human health. Diets can either affect the gut microbiota resulting in alterations in the host’s physiological responses or by directly targeting the host response. The microbial community in the mammalian gut is a complex and dynamic system crucial for the development and maturation of both systemic and mucosal immune responses. Therefore, the complex interaction between available nutrients, the microbiota, and the immune system are central regulators in maintaining homeostasis and fighting against invading pathogens at mucosal sites. Westernized diet, defined as high dietary intake of saturated fats and sucrose and low intake of fiber, represent a growing health risk contributing to the increased occurrence of metabolic diseases, e.g., diabetes and obesity in countries adapting a westernized lifestyle. Inflammatory bowel diseases (IBD) and asthma are chronic mucosal inflammatory conditions of unknown etiology with increasing prevalence worldwide. These conditions have a multifactorial etiology including genetic factors, environmental factors, and dysregulated immune responses. Their increased prevalence cannot solely be attributed to genetic considerations implying that other factors such as diet can be a major contributor. Recent reports indicate that the gut microbiota and modifications thereof, due to a consumption of a diet high in saturated fats and low in fibers, can trigger factors regulating the development and/or progression of both conditions. While asthma is a disease of the airways, increasing evidence indicates a link between the gut and airways in disease development. Herein, we provide a comprehensive review on the impact of westernized diet and associated nutrients on immune cell responses and the microbiota and how these can influence the pathology of IBD and asthma. PMID:28804483

Queen Quality and the Impact of Honey Bee Diseases on Queen Health: Potential for Interactions between Two Major Threats to Colony Health.

PubMed

Amiri, Esmaeil; Strand, Micheline K; Rueppell, Olav; Tarpy, David R

2017-05-08

Western honey bees, Apis mellifera , live in highly eusocial colonies that are each typically headed by a single queen. The queen is the sole reproductive female in a healthy colony, and because long-term colony survival depends on her ability to produce a large number of offspring, queen health is essential for colony success. Honey bees have recently been experiencing considerable declines in colony health. Among a number of biotic and abiotic factors known to impact colony health, disease and queen failure are repeatedly reported as important factors underlying colony losses. Surprisingly, there are relatively few studies on the relationship and interaction between honey bee diseases and queen quality. It is critical to understand the negative impacts of pests and pathogens on queen health, how queen problems might enable disease, and how both factors influence colony health. Here, we review the current literature on queen reproductive potential and the impacts of honey bee parasites and pathogens on queens. We conclude by highlighting gaps in our knowledge on the combination of disease and queen failure to provide a perspective and prioritize further research to mitigate disease, improve queen quality, and ensure colony health.

Un Corazón Saludable: factors influencing outcomes of an exercise program designed to impact cardiac and metabolic risks among urban Latinas.

PubMed

Harralson, Tina L; Emig, Julie Cousler; Polansky, Marcia; Walker, Renee E; Cruz, Joanna Otero; Garcia-Leeds, Claudia

2007-12-01

A high prevalence of physical inactivity, metabolic risk factors, and depression place Latinas in peril of developing cardiovascular disease. "Un Corazón Saludable: A Healthy Heart" was developed to engage urban Latinas in physical activity and increase awareness of cardiac and metabolic risk factors. Two hundred and twenty-five Latinas enrolled in the program that included salsa aerobics and culturally sensitive health education modules. Cardiac and metabolic risk factors measured in this study were body mass index (BMI), waist-to-hip ratio, abdominal obesity, and blood pressure. Psychosocial risk factors measured included depressive symptoms and perceived social support. Fifty-two percent of the enrollees completed the program. Results indicated decreases in BMI, abdominal obesity, and symptoms of depression among Latinas who completed the program. Those who did not complete the program were younger, had greater depressive symptomatology, reported poorer social support, and they tended to be caregivers and U.S. born. Focus groups of program participants ascertained that caregiving and family obligations were major barriers to exercise while social support was a major facilitator of exercise. This research indicates that programs developed to recognize and address cultural barriers can impact physical and psychosocial risk factors among urban Latinas who are able to attend. Program retention may improve if future exercise programs conducted through community-base organizations offered support to Latinas regarding issues that interfere with self-care and health promotion. Future programs should consider including mental health and social service case management as part of comprehensive exercise/educational programs.

Impact phenomena as factors in the evolution of the Earth

NASA Technical Reports Server (NTRS)

Grieve, R. A. F.; Parmentier, E. M.

1984-01-01

It is estimated that 30 to 200 large impact basins could have been formed on the early Earth. These large impacts may have resulted in extensive volcanism and enhanced endogenic geologic activity over large areas. Initial modelling of the thermal and subsidence history of large terrestrial basins indicates that they created geologic and thermal anomalies which lasted for geologically significant times. The role of large-scale impact in the biological evolution of the Earth has been highlighted by the discovery of siderophile anomalies at the Cretaceous-Tertiary boundary and associated with North American microtektites. Although in neither case has an associated crater been identified, the observations are consistent with the deposition of projectile-contaminated high-speed ejecta from major impact events. Consideration of impact processes reveals a number of mechanisms by which large-scale impact may induce extinctions.

At the Leading Front of Neuroscience: A Bibliometric Study of the 100 Most-Cited Articles

PubMed Central

Yeung, Andy W. K.; Goto, Tazuko K.; Leung, W. Keung

2017-01-01

Background: It might be difficult for clinicians and scientists to identify comprehensively the major research topics given the large number of publications. A bibliometric report that identifies the most-cited articles within the body of the relevant literature may provide insight and guidance for readers toward scientific topics that are considered important for researchers and all relevant workers of academia. To our knowledge, there is a lack of an overall evaluation of the most-cited articles and hence of a comprehensive review of major research topics in neuroscience. The present study was therefore proposed to analyze and characterize the 100 most-cited articles in neuroscience. Methods: Based on data provided from Web of Science, the 100 most-cited articles relevant to neuroscience were identified and characterized. Information was extracted for each included article to assess for the publication year, journal published, impact factor, adjusted impact factor, citation count (total, normalized, and adjusted), reference list, authorship and article type. Results: The total citation count for the 100 most-cited articles ranged from 7,326 to 2,138 (mean 3087.0) and the normalized citation count ranged from 0.163 to 0.007 (mean 0.054). The majority of the 100 articles were research articles (67%) and published from 1996 to 2000 (30%). The author and journal with the largest share of these 100 articles were Stephen M. Smith (n = 6) and Science (n = 13) respectively. Among the 100 most-cited articles, 37 were interlinked via citations of one another, and they could be classified into five major topics, four of which were scientific topics, namely neurological disorders, prefrontal cortex/emotion/reward, brain network, and brain mapping. The remaining topic was methodology. Interestingly 41 out of 63 of the rest, non-interlinked articles could also be categorized under the above five topics. Adjusted journal impact factor among these 100 articles did not appear to be associated with the corresponding adjusted citation count. Conclusion: The current study compiles a comprehensive list and analysis of the 100 most-cited articles relevant to neuroscience that enables the comprehensive identification and recognition of the most important and relevant research topics concerned. PMID:28785211

At the Leading Front of Neuroscience: A Bibliometric Study of the 100 Most-Cited Articles.

PubMed

Yeung, Andy W K; Goto, Tazuko K; Leung, W Keung

2017-01-01

Background: It might be difficult for clinicians and scientists to identify comprehensively the major research topics given the large number of publications. A bibliometric report that identifies the most-cited articles within the body of the relevant literature may provide insight and guidance for readers toward scientific topics that are considered important for researchers and all relevant workers of academia. To our knowledge, there is a lack of an overall evaluation of the most-cited articles and hence of a comprehensive review of major research topics in neuroscience. The present study was therefore proposed to analyze and characterize the 100 most-cited articles in neuroscience. Methods: Based on data provided from Web of Science, the 100 most-cited articles relevant to neuroscience were identified and characterized. Information was extracted for each included article to assess for the publication year, journal published, impact factor, adjusted impact factor, citation count (total, normalized, and adjusted), reference list, authorship and article type. Results: The total citation count for the 100 most-cited articles ranged from 7,326 to 2,138 (mean 3087.0) and the normalized citation count ranged from 0.163 to 0.007 (mean 0.054). The majority of the 100 articles were research articles (67%) and published from 1996 to 2000 (30%). The author and journal with the largest share of these 100 articles were Stephen M. Smith ( n = 6) and Science ( n = 13) respectively. Among the 100 most-cited articles, 37 were interlinked via citations of one another, and they could be classified into five major topics, four of which were scientific topics, namely neurological disorders, prefrontal cortex/emotion/reward, brain network, and brain mapping. The remaining topic was methodology. Interestingly 41 out of 63 of the rest, non-interlinked articles could also be categorized under the above five topics. Adjusted journal impact factor among these 100 articles did not appear to be associated with the corresponding adjusted citation count. Conclusion: The current study compiles a comprehensive list and analysis of the 100 most-cited articles relevant to neuroscience that enables the comprehensive identification and recognition of the most important and relevant research topics concerned.

The impact and effectiveness of health impact assessment: A conceptual framework

DOE Office of Scientific and Technical Information (OSTI.GOV)

Harris-Roxas, Ben, E-mail: ben@harrisroxashealth.com; Harris, Elizabeth, E-mail: e.harris@unsw.edu.au

2013-09-15

The use of health impact assessment (HIA) has expanded rapidly and there are increasing demands for it to demonstrate its effectiveness. This paper presents a conceptual framework for evaluating HIA and describes its development through (i) a review of the literature, (ii) a review of work undertaken as part of a major HIA capacity building project and (iii) an in-depth study of seven completed HIAs. The framework emphasises context, process and impacts as key domains in understanding and evaluating the effectiveness of an HIA. This new framework builds upon the existing approaches to evaluating HIA and extends them to reflectmore » the broad range of factors that comprise and influence the effectiveness of HIAs. It may be of use in evaluating completed HIAs and in planning HIAs that are yet to be undertaken. -- Highlights: ► The first empirically-derived conceptual framework for evaluating HIA ► It may also be useful for planning and reporting on HIAs. ► The framework emphasises context, process and impacts as key domains. ► A broad range of factors influence the effectiveness of HIAs.« less

Species traits and network structure predict the success and impacts of pollinator invasions.

PubMed

Valdovinos, Fernanda S; Berlow, Eric L; Moisset de Espanés, Pablo; Ramos-Jiliberto, Rodrigo; Vázquez, Diego P; Martinez, Neo D

2018-05-31

Species invasions constitute a major and poorly understood threat to plant-pollinator systems. General theory predicting which factors drive species invasion success and subsequent effects on native ecosystems is particularly lacking. We address this problem using a consumer-resource model of adaptive behavior and population dynamics to evaluate the invasion success of alien pollinators into plant-pollinator networks and their impact on native species. We introduce pollinator species with different foraging traits into network models with different levels of species richness, connectance, and nestedness. Among 31 factors tested, including network and alien properties, we find that aliens with high foraging efficiency are the most successful invaders. Networks exhibiting high alien-native diet overlap, fraction of alien-visited plant species, most-generalist plant connectivity, and number of specialist pollinator species are the most impacted by invaders. Our results mimic several disparate observations conducted in the field and potentially elucidate the mechanisms responsible for their variability.

Can reoperative surgery be profitable? Maximizing reimbursement.

PubMed

Senagore, Anthony J

2006-11-01

It is interesting to review the topic of reoperative surgery from the aspect of cost-effectiveness or, worse yet, profitability for either the institution or surgeon. The majority of the published material focuses on indications, risk factors, and short- and long-term outcomes. The context of the discussion is framed by the question "Can you make money doing reoperative surgery?" The short answer is that if this is all you do, probably not. Few, if any, publications assess the impact a redo procedure has on the factors that directly affect the fee schedule: surgeon time consumption (intraoperative and postoperative), stress (physical and psychological), and malpractice effects. Far more work needs to be done to understand the cost and resource consumption effects of major reoperative surgery.

Predicting how altering propagule pressure changes establishment rates of biological invaders across species pools

Treesearch

Eckehard G. Brockerhoff; Mark Kimberley; Andrew M. Liebhold; Robert A. Haack; Joseph F. Cavey

2014-01-01

Biological invasions resulting from international trade can cause major environmental and economic impacts. Propagule pressure is perhaps the most important factor influencing establishment, although actual arrival rates of species are rarely recorded. Furthermore, the pool of potential invaders includes many species that vary in their arrival rate and establishment...

The disease complex of the gypsy moth. 1. Major components

Treesearch

R.W. Campbell; J.D. Podgwaite

1971-01-01

A study was undertaken to elucidate the impact of the various components of disease on natural populations of the gypsy moth, Porthetria dispar. Diseased larvae from both sparse and dense populations were examined and categorized on the basis of etiologic and nonetiologic mortality factors. Results indicated a significantly higher incidence of...

Perceptions of Teacher Expectations by African American High School Students

ERIC Educational Resources Information Center

Pringle, Beverley E.; Lyons, James E.; Booker, Keonya C.

2010-01-01

African American high school students are performing behind their White classmates regardless of whether they are in majority or minority populations at school. Teacher expectations, among school-related factors that can impact the academic achievement of African American high school students, are the focus of this study. Interviews were conducted…

The impact of tillage on Pinto bean cultivar response to drought induced by deficit irrigation

USDA-ARS?s Scientific Manuscript database

Drought stress is a major factor limiting yield of dry bean (Phaseolus vulgaris) and drought tolerant cultivars are being developed. Reducing tillage in row crops has advantages of conserving moisture and increasing water infiltration, and may alter the response of dry bean cultivars to drought stre...

Particulate-phase mercury emissions from biomass burning and impact on resulting deposition: a modelling assessment

EPA Science Inventory

Mercury (Hg) emissions from biomass burning (BB) are an important source of atmospheric Hg and a major factor driving the interannual variation of Hg concentrations in the troposphere. The greatest fraction of Hg from BB is released in the form of elemental Hg (Hg0(g)). However, ...

Examining the Impact of Non-Technical Security Management Factors on Information Security Management in Health Informatics

ERIC Educational Resources Information Center

Imam, Abbas H.

2013-01-01

Complexity of information security has become a major issue for organizations due to incessant threats to information assets. Healthcare organizations are particularly concerned with security owing to the inherent vulnerability of sensitive information assets in health informatics. While the non-technical security management elements have been at…

Attendance and Achievement in Problem-Based Learning: The Value of Scaffolding

ERIC Educational Resources Information Center

Smith, Mike; Cook, Kathryn

2012-01-01

The impact of problem-based learning (PBL) in improving academic achievement comparedwith other forms of teaching is equivocal. This paper argues that poor tutorial preparation and vague reporting of the brainstorming stage of PBL are major contributing factors. To address these issues this study incorporated a scaffolding mechanism into the…

Importance of resonance interference effects in multigroup self-shielding calculation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stachowski, R.E.; Protsik, R.

1995-12-31

The impact of the resonance interference method (RIF) on multigroup neutron cross sections is significant for major isotopes in the fuel, indicating the importance of resonance interference in the computation of gadolinia burnout and plutonium buildup. The self-shielding factor method with the RIF method effectively eliminates shortcomings in multigroup resonance calculations.

The Impact of College Experiences on Conventional Career Logic

ERIC Educational Resources Information Center

Baumgardner, Steve R.

1976-01-01

The factors students consider in choosing a college major were scaled on an analytic-intuitive dimension. Differences in thinking orientation were found to be associated with students's sex, area of study, and year in school. Overall, the apparent lack of explicit rationality in student educational decisions appears to be adaptive. (Author)

Impact of Undergraduates' Stereotypes of Scientists on Their Intentions to Pursue a Career in Science

ERIC Educational Resources Information Center

Schneider, Jennifer

2010-01-01

Women remain disproportionately underrepresented in certain science, technology, engineering, and math (STEM) majors and occupations. Stereotypes of scientists may be contributing factors in this phenomenon. However, this relationship has not yet been empirically examined. This is partly because of the dearth of literature addressing the…

Land Reform and Social Change in Colombia.

ERIC Educational Resources Information Center

Hirschman, Albert O.; And Others

This conference report focuses on three major areas of interest: (1) land reform in Colombia, (2) social change in Popayan, and (3) implications for research in agrarian structure in Colombia. A case study dealing with Colombia's sequence of moves toward land reform over the last 40 years is reviewed. The impact of political factors and social…

Relationship between Journal-Ranking Metrics for a Multidisciplinary Set of Journals

ERIC Educational Resources Information Center

Perera, Upeksha; Wijewickrema, Manjula

2018-01-01

Ranking of scholarly journals is important to many parties. Studying the relationships among various ranking metrics is key to understanding the significance of one metric based on another. This research investigates the relationship among four major journal-ranking indicators: the impact factor (IF), the Eigenfactor score (ES), the "h."…

Investigative workshop for mathematical modeling of Johne's disease epidemiology and immunology

USDA-ARS?s Scientific Manuscript database

Despite long and intensive national-level efforts for Johne’s disease (JD) control, we are still far from preventing the significant economic impact of this formidable disease. One of the major reasons for the continuing struggle with JD is that there are many unknown factors in JD epidemiology and ...

A Laboratory Comparison of Emission Factors, Number Size Distributions, and Morphology of Ultrafine Particles from 11 Different Household Cookstove-Fuel Systems

EPA Science Inventory

Ultrafine particle (UFP) emissions and particle number size distributions (PNSD) are critical in the evaluation of air pollution impacts on human health and climate change. Residential cookstove emissions are a major source of many air pollutants; however, data on UFP number emis...

Genome-wide association mapping of carbon isotope and oxygen isotope ratios in diverse soybean genotypes

USDA-ARS?s Scientific Manuscript database

Water deficit stress is a major factor limiting soybean [Glycine max (L.) Merr.] yield. High water use efficiency (WUE) offers a means to potentially ameliorate drought impact, but increased WUE is often associated with a reduction in transpiration (T) and an accompanied reduction in photosynthesis....

Connected Representations of Knowledge: Do Undergraduate Students Relate Algebraic Rational Expressions to Rational Numbers?

ERIC Educational Resources Information Center

Yantz. Jennifer

2013-01-01

The attainment and retention of later algebra skills in high school has been identified as a factor significantly impacting students' postsecondary success as STEM majors. Researchers maintain that learners develop meaning for algebraic procedures by forming connections to the basic number system properties. In the present study, the connections…

A Descriptive Analysis of the Principalship in New Jersey: 1996-2011

ERIC Educational Resources Information Center

Gristina, Matthew

2014-01-01

Understanding how the behaviors and actions of building principals impact student achievement is a major goal of educational leadership, in which both direct and indirect factors exist. There is a wealth of research which focuses on the importance of school leadership and demonstrates that building level administrators are second only to classroom…

The Impact of Modern Information and Communication Technologies on Social Movements

ERIC Educational Resources Information Center

Konieczny, Piotr

2012-01-01

Information and communication technologies (ICTs) have empowered non-state social actors, notably, social movements. They were quick to seize ICTs in the past (printing presses, television, fax machines), which was a major factor in their successes. Mass email campaigns, blogs, their audio- and video- variants (the podcasts and the videocasts),…

Treatment outcomes, quality of life, and impact of hemophilia on young adults (aged 18-30 years) with hemophilia.

PubMed

Witkop, Michelle; Guelcher, Christine; Forsyth, Angela; Hawk, Sarah; Curtis, Randall; Kelley, Laureen; Frick, Neil; Rice, Michelle; Rosu, Gabriela; Cooper, David L

2015-12-01

The Hemophilia Experiences, Results and Opportunities (HERO) initiative assessed psychosocial issues reported by people with moderate to severe hemophilia and was led by a multidisciplinary international advisory board. This analysis reports data from young adult respondents (aged 18-30 years), including both US and overall global (including US respondents) results, and investigates treatment outcomes, quality of life, and impacts of hemophilia on relationships. More young adults in HERO received prophylaxis than on-demand treatment, although a majority reported not using factor products exactly as prescribed, and 50% of global respondents and 26% of US respondents reported issues with access to factor replacement therapy in the previous 5 years. Many young adults with hemophilia reported comorbidities, including bone/skeletal arthritis, chronic pain, and viral infections, and nearly half of young adults reported anxiety/depression. Most reported pain interference with daily activities in the past 4 weeks, although a majority reported participating in lower-risk activities and approximately half in intermediate-risk activities. Most young adults were very or quite satisfied with the support of partners/spouses, family, and friends, although roughly one-third reported that hemophilia affected their ability to develop close relationships with a partner. A majority of young adults reported that hemophilia has had a negative impact on employment, and 62% of global respondents and 78% of US respondents were employed at least part-time. Together these data highlight the psychosocial issues experienced by young adults with hemophilia and suggest that increased focus on these issues may improve comprehensive care during the transition to adulthood. © 2015 Wiley Periodicals, Inc.

Marketing prospects for Illinois basin coals

DOE Office of Scientific and Technical Information (OSTI.GOV)

McMahan, R.

1994-12-31

A perspective is given of markets for Illinois Basin coals within the national context. In recent years, prospects have started to brighten slightly for a series of reasons. First, production trends, transportation issues, marketing and the outlook are discussed. Some of the factors that are going to be important to watch in the future; for instance, the way the acid rain bill actually shakes out in the next couple of years; other environmental restrictions that could end up having a reverse impact on some Illinois Basin coals; and generally, what may happen as a result of the major movements towardmore » deregulation in the utility industry are described. These factors are going to have a significant impact on the coal industry altogether.« less

ARS turns fifteen: la quinceañera bonita.

PubMed

Sen, Chandan K

2013-01-01

ARS was aimed at advancing the erstwhile niche field of redox biology to a more central position in research. Currently, ARS ranks first (impact factor: 8.456) in the field of redox biology. Of 8336 journals listed in Journal Citation Reports, ARS ranks 205th. The next journal in redox biology ranks 449th. ARS ranks 169th of 8336 in immediacy index. The next journal in redox biology ranks 923rd. Thus, ARS is the primary source of hot papers in redox sciences and healthcare. To grow footprint and overall impact, ARS has nearly doubled the annual publication volume from roughly 200 to 400 in one year. Because the manuscript volume represents the denominator of the impact factor calculation, such a sharp increase in volume would be predicted to a proportionally lower impact factor. Because of the robust current upward momentum, ARS will be affected less than that predicted by simple arithmetic and will maintain its top position even after such aggressive volume expansion. As another year passes, the additional manuscripts will get more time to be cited, and therefore the impact factor is expected to bounce back resulting in a much stronger journal with a substantially enhanced overall presence. ARS currently publishes 36 issues annually as two series: ARS-Discoveries, and ARS-Therapeutics. Redox biology does have the potential of major health impact. ARS-Therapeutics is the first and only forum dedicated to highlight that strength. I am grateful to the global redox village for their unreserved support to raise ARS and this fascinating field of redox research and healthcare. Antioxid. Redox Signal. 18, 1-4.

Aquatic chemistry of flood events

NASA Astrophysics Data System (ADS)

Klavins, Maris; Rodinov, Valery

2015-04-01

During flood events a major discharge of water and dissolved substances happens. However flood waters very much differs from water composition during low-water events. Aquatic chemistry of flood waters also is of importance at the calculation of loadings as well as they might have major impact on water quality in receiving water bodies (lakes, coastal waters and seas). Further flood regime of rivers is subjected to changes due to climate change and growing impact of human activities. The aim of this study is to analyse water chemical composition changes during flood events in respect to low water periods, character of high-water events and characteristics of the corresponding basin. Within this study, the concentrations of major dissolved substances in the major rivers of Latvia have been studied using monitoring data as well as field studies during high water/ low water events. As territories of studies flows of substances in river basins/subbasins with different land-use character and different anthropogenic impacts has been studied to calculate export values depending on the land-use character. Impact of relations between dissolved substances and relations in respect to budgets has been calculated. The dynamics of DOC, nutrient and major dissolved substance flows depending on landuse pattern and soil properties in Latvia has been described, including emissions by industrial and agricultural production. In these changes evidently climate change signals can be identified. The water chemistry of a large number of rivers during flood events has been determined and the possible impact of water chemical composition on DOC and nutrient flows has been evaluated. Long-term changes (1977-2013) of concentrations of dissolved substances do not follow linear trends but rather show oscillating patterns, indicating impact of natural factors, e.g. changing hydrological and climatic conditions. There is a positive correlation between content of inert dissolved substances and water discharge. This study did not reveal a clear correlation between the concentrations of dissolved substances and land-use types within the river basin. Conclusions in respect to calculation needed for loading calculations has been done. Acknowledgement: support from a Latvia Science Council grant "Stability of climate system and its impacts on water quality limiting biogeochemical flows in Latvia"

Estimating drought risk across Europe from reported drought impacts, hazard indicators and vulnerability factors

NASA Astrophysics Data System (ADS)

Blauhut, V.; Stahl, K.; Stagge, J. H.; Tallaksen, L. M.; De Stefano, L.; Vogt, J.

2015-12-01

Drought is one of the most costly natural hazards in Europe. Due to its complexity, drought risk, the combination of the natural hazard and societal vulnerability, is difficult to define and challenging to detect and predict, as the impacts of drought are very diverse, covering the breadth of socioeconomic and environmental systems. Pan-European maps of drought risk could inform the elaboration of guidelines and policies to address its documented severity and impact across borders. This work (1) tests the capability of commonly applied hazard indicators and vulnerability factors to predict annual drought impact occurrence for different sectors and macro regions in Europe and (2) combines information on past drought impacts, drought hazard indicators, and vulnerability factors into estimates of drought risk at the pan-European scale. This "hybrid approach" bridges the gap between traditional vulnerability assessment and probabilistic impact forecast in a statistical modelling framework. Multivariable logistic regression was applied to predict the likelihood of impact occurrence on an annual basis for particular impact categories and European macro regions. The results indicate sector- and macro region specific sensitivities of hazard indicators, with the Standardised Precipitation Evapotranspiration Index for a twelve month aggregation period (SPEI-12) as the overall best hazard predictor. Vulnerability factors have only limited ability to predict drought impacts as single predictor, with information about landuse and water resources as best vulnerability-based predictors. (3) The application of the "hybrid approach" revealed strong regional (NUTS combo level) and sector specific differences in drought risk across Europe. The majority of best predictor combinations rely on a combination of SPEI for shorter and longer aggregation periods, and a combination of information on landuse and water resources. The added value of integrating regional vulnerability information with drought risk prediction could be proven. Thus, the study contributes to the overall understanding of drivers of drought impacts, current practice of drought indicators selection for specific application, and drought risk assessment.

Estimating drought risk across Europe from reported drought impacts, drought indices, and vulnerability factors

NASA Astrophysics Data System (ADS)

Blauhut, Veit; Stahl, Kerstin; Stagge, James Howard; Tallaksen, Lena M.; De Stefano, Lucia; Vogt, Jürgen

2016-07-01

Drought is one of the most costly natural hazards in Europe. Due to its complexity, drought risk, meant as the combination of the natural hazard and societal vulnerability, is difficult to define and challenging to detect and predict, as the impacts of drought are very diverse, covering the breadth of socioeconomic and environmental systems. Pan-European maps of drought risk could inform the elaboration of guidelines and policies to address its documented severity and impact across borders. This work tests the capability of commonly applied drought indices and vulnerability factors to predict annual drought impact occurrence for different sectors and macro regions in Europe and combines information on past drought impacts, drought indices, and vulnerability factors into estimates of drought risk at the pan-European scale. This hybrid approach bridges the gap between traditional vulnerability assessment and probabilistic impact prediction in a statistical modelling framework. Multivariable logistic regression was applied to predict the likelihood of impact occurrence on an annual basis for particular impact categories and European macro regions. The results indicate sector- and macro-region-specific sensitivities of drought indices, with the Standardized Precipitation Evapotranspiration Index (SPEI) for a 12-month accumulation period as the overall best hazard predictor. Vulnerability factors have only limited ability to predict drought impacts as single predictors, with information about land use and water resources being the best vulnerability-based predictors. The application of the hybrid approach revealed strong regional and sector-specific differences in drought risk across Europe. The majority of the best predictor combinations rely on a combination of SPEI for shorter and longer accumulation periods, and a combination of information on land use and water resources. The added value of integrating regional vulnerability information with drought risk prediction could be proven. Thus, the study contributes to the overall understanding of drivers of drought impacts, appropriateness of drought indices selection for specific applications, and drought risk assessment.

Psychosocial impact of mothers with perinatal loss and its contributing factors: an insight.

PubMed

Sutan, Rosnah; Amin, Rosnah Mohamad; Ariffin, Khatija Banu; Teng, Tang Zoun; Kamal, Mohd Faiz; Rusli, Rusli Zaim

2010-03-01

To evaluate the psychosocial impact among mothers with perinatal loss and its contributing factors. A cross sectional study was conducted in University Kebangsaan Malaysia Medical Centre (UKMMC) from April 2008 to May 2009 using Edinburgh Postnatal Depression Scale (EPDS) and self administered questionnaire. Sixty-two respondents were included and most of them were working mothers (77.4%). The mean age of the respondents was (31.0+/-5.6) years and a majority of the subjects aged between 20-34 years (77.4%). According to the EPDS score, 53.2% of the respondents had a psychosocial impact with a total score of >9, out of 30. There was a significant relationship between psychosocial impact after perinatal loss and support from friends (P=0.019). However, there were no significant differences between psychosocial impact and history of previous perinatal loss, ethnicity, occupation, educational level, age or total income. Mothers with perinatal loss should be screened for psychosocial impact and offered support when needed. Family and friends should continue to provide emotional support. People who have experienced similar problem before will be able to provide better support than those who have not.

Psychosocial impact of mothers with perinatal loss and its contributing factors: an insight*

PubMed Central

Sutan, Rosnah; Amin, Rosnah Mohamad; Ariffin, Khatija Banu; Teng, Tang Zoun; Kamal, Mohd Faiz; Rusli, Rusli Zaim

2010-01-01

Objective: To evaluate the psychosocial impact among mothers with perinatal loss and its contributing factors. Methods: A cross sectional study was conducted in University Kebangsaan Malaysia Medical Centre (UKMMC) from April 2008 to May 2009 using Edinburgh Postnatal Depression Scale (EPDS) and self administered questionnaire. Results: Sixty-two respondents were included and most of them were working mothers (77.4%). The mean age of the respondents was (31.0±5.6) years and a majority of the subjects aged between 20–34 years (77.4%). According to the EPDS score, 53.2% of the respondents had a psychosocial impact with a total score of >9, out of 30. There was a significant relationship between psychosocial impact after perinatal loss and support from friends (P=0.019). However, there were no significant differences between psychosocial impact and history of previous perinatal loss, ethnicity, occupation, educational level, age or total income. Conclusion: Mothers with perinatal loss should be screened for psychosocial impact and offered support when needed. Family and friends should continue to provide emotional support. People who have experienced similar problem before will be able to provide better support than those who have not. PMID:20205307

Factors that impact nurses' use of electronic mail (e-mail).

PubMed

Hughes, J A; Pakieser, R A

1999-01-01

As electronic applications are used increasingly in healthcare, nurses are being challenged to adopt them. Electronic mail (e-mail) is an electronic tool with general as well as healthcare uses. E-mail use may be an opportunity to learn a tool that requires skills similar to those used in other applications. This study aimed to identify barriers and facilitators that impact nurses' use of e-mail in the workplace. Data for this study were gathered using focus group methodology. Content analysis identified and labeled factors into seven major categories. Specific factors identified were generally consistent with those previously described in the literature as affecting use of computers in general. However, there were several additional factors identified that were not reported in other previous studies: lack of face-to-face communication, individual writing skills, recency of any educational experience, volume of mail received, password integrity, and technical support. Findings from this study provide information for any individual involved in introducing or updating an e-mail system in a healthcare environment.

Biotherapeutic formulation factors affecting metal leachables from stainless steel studied by design of experiments.

PubMed

Zhou, Shuxia; Evans, Brad; Schöneich, Christian; Singh, Satish K

2012-03-01

Trace amounts of metals are inevitably present in biotherapeutic products. They can arise from various sources. The impact of common formulation factors such as protein concentration, antioxidant, metal chelator concentration and type, surfactant, pH, and contact time with stainless steel on metal leachables was investigated by a design of experiments approach. Three major metal leachables, iron, chromium, and nickel were monitored by inductively coupled plasma-mass spectrometry. It was observed that among all the tested factors, contact time, metal chelator concentration, and protein concentration were statistically significant factors with higher temperature resulting in higher levels of leached metals. Within a pH range of 5.5-6.5, solution pH played a minor role for chromium leaching at 25°C. No statistically significant difference was observed due to type of chelator, presence of antioxidant, or surfactant. In order to optimize a biotherapeutic formulation to achieve a target drug product shelf life with acceptable quality, each formulation component must be evaluated for its impact.

Team-Based Learning in US Colleges and Schools of Pharmacy

PubMed Central

Copeland, Jeffrey; Franks, Andrea S.; Karimi, Reza; McCollum, Marianne; Riese, David J.; Lin, Anne Y.F.

2013-01-01

Objective. To characterize the use of team-based learning (TBL) in US colleges and schools of pharmacy, including factors that may affect implementation and perceptions of faculty members regarding the impact of TBL on educational outcomes. Methods. Respondents identified factors that inhibit or enable TBL use and its impact on student learning. Results were stratified by type of institution (public/private), class size, and TBL experience. Results. Sixty-nine of 100 faculty members (69%) representing 43 (86%) institutions responded. Major factors considered to enable TBL implementation included a single campus and student and administration buy-in. Inhibiting factors included distant campuses, faculty resistance, and lack of training. Compared with traditional lectures, TBL is perceived to enhance student engagement, improve students’ preparation for class, and promote achievement of course outcomes. In addition, TBL is perceived to be more effective than lectures at fostering learning in all 6 domains of Bloom’s Taxonomy. Conclusions. Despite potential implementation challenges, faculty members perceive that TBL improves student engagement and learning. PMID:23966718

Multi-criteria Analysis of Factors for Application of Concrete Composites Considering Their Environmental Harmfulness

NASA Astrophysics Data System (ADS)

Paulikova, A.; Estokova, A.; Mitterpach, J.

2017-10-01

The analysis of factors is important in insight of the selection of proper building material with environmental added value. A comprehensive solution is possible if at the beginning there are all the relevant factors in detail characterized predominately that have got a major impact on the area in terms of environmentalharmfulness prevention. There are many groups of environmental factors. In this article only four factors are considered, i.e. contain of CrVI (mg/kg) and index of mass activity for radionuclides (Ra, Th, K) which are the most harmful. These factors can be evaluated by means of a supplementary tool, e.g. multi-criteriaanalysis, which improves and supports decision processes in the framework of construction bybuilding management, etc.

Gender Differences in Self-Efficacy and Sense of Class and School Belonging for Majors in Science, Technology, Engineering, and Mathematics (STEM) Disciplines

NASA Astrophysics Data System (ADS)

Hogue, Barbara A.

Research into women's underrepresentation in science, technology, engineering, and mathematics (STEM) disciplines has become a topic of interest due to the increasing need for employees with technical expertise and a shortage of individuals to fill STEM jobs. The discrepancy in women's representation between STEM and other fields cannot adequately be explained by factors such as women's need to balance work and family (medicine and law are both extremely demanding careers), women's fear of competition (admissions into medical and law schools are highly competitive), or women's inability to excel in science (e.g., entry into medicine requires excellent achievement in the basic sciences). The purpose of this study is to gain a deeper understanding of the role and/or impact a sense of belonging has inside and outside of STEM classrooms. Research questions focused on the role and/or impact of belonging contributes to students' self-efficacy beliefs as a STEM major. Bandura's self-efficacy theory serves as the theoretical framework. Data sources include close-ended surveys of 200 sophomore- and junior-level college students majoring in a STEM discipline. A quantitative exploratory approach allowed participants' responses to be analyzed using both correlation and multiple regression analyses to understand whether a student's sense of belonging is associated with his or her self-efficacy beliefs. Findings suggested that positive support systems impact students' self-efficacy and play a role in fostering students' motivation and decision to major in STEM disciplines. This study contributes to positive social change by providing empirical evidence faculty and administrators may use to promote university-based STEM support programs reflecting the impact belonging has on students' self-efficacy and potentially increasing the number of students majoring in STEM disciplines.

The unexplored relationship between urinary tract infections and the autonomic nervous system.

PubMed

Hibbing, Michael E; Conover, Matt S; Hultgren, Scott J

2016-10-01

Urinary tract infections (UTIs), the majority of which are caused by uropathogenic E. coli (UPEC), are extremely common infections that preferentially effect women. Additional complicating factors, such as catheterization, diabetes, and spinal cord injuries can increase the frequency and severity of UTIs. The rise of antimicrobial resistant uropathogens and the ability of this disease to chronically recur make the development of alternative preventative and therapeutic modalities a priority. The major symptoms of UTIs, urgency, frequency, and dysuria, are readouts of the autonomic nervous system (ANS) and the majority of the factors that lead to complicated UTIs have been shown to impact ANS function. This review summarizes the decades' long efforts to understand the molecular mechanisms of the interactions between UPEC and the host, with a particular focus on the recent findings revealing the molecular, bacteriological, immunological and epidemiological complexity of pathogenesis. Additionally, we describe the progress that has been made in: i) generating vaccines and anti-virulence compounds that prevent and/or treat UTI by blocking bacterial adherence to urinary tract tissue and; and ii) elucidating the mechanism by which anti-inflammatories are able to alleviate symptoms and improve disease prognosis. Finally, the potential relationships between the ANS and UTI are considered throughout. While these relationships have not been experimentally explored, the known interactions between numerous UTI characteristics (symptoms, complicating factors, and inflammation) and ANS function suggest that UTIs are directly impacting ANS stimulation and that ANS (dys)function may alter UTI prognosis. Copyright © 2015 Elsevier B.V. All rights reserved.

The impact of the duration of an untreated episode on improvement of depression and somatic symptoms

PubMed Central

Hung, Ching-I; Yu, Nan-Wen; Liu, Chia-Yih; Wu, Kuan-Yi; Yang, Ching-Hui

2015-01-01

Purpose The aim of this study was to investigate the impact of the duration of an untreated episode (DUE) on the improvement of depression and somatic symptoms among patients with major depressive disorder (MDD), after the patients had received 4 weeks of pharmacotherapy. Methods In this open-label study, there were 155 participants with MDD who were treated daily with 75 mg of venlafaxine for 4 weeks. DUE was defined as the interval between the onset of the index major depressive episode and the start of pharmacotherapy. The Depression and Somatic Symptoms Scale (DSSS), composed of the depression subscale (DS) and the somatic subscale (SS), was used. The SS included the pain subscale (PS) and the nonpain somatic subscale (NPSS). Multiple linear regressions were used to test the impacts of DUE on the improvement percentages (IPs) of depression and somatic symptoms. Results Eighty-five subjects completed the 4-week treatment. The IPs of the DS, SS, and NPSS were significantly negatively correlated with DUE. A shorter DUE was related to higher IPs. DUE was an independent factor, predicting the IPs of the DS, SS, and NPSS. DUE <1 month was the most powerful time-point to predict the IPs of the DS, SS, and NPSS. However, DUE was unable to predict the IP of the PS at all time-points. Conclusion A shorter DUE might be one of the factors related to greater improvement of depression and somatic symptoms. DUE should be considered as an important factor when investigating the prognosis of depression and somatic symptoms. PMID:26346571

The impact of the duration of an untreated episode on improvement of depression and somatic symptoms.

PubMed

Hung, Ching-I; Yu, Nan-Wen; Liu, Chia-Yih; Wu, Kuan-Yi; Yang, Ching-Hui

2015-01-01

The aim of this study was to investigate the impact of the duration of an untreated episode (DUE) on the improvement of depression and somatic symptoms among patients with major depressive disorder (MDD), after the patients had received 4 weeks of pharmacotherapy. In this open-label study, there were 155 participants with MDD who were treated daily with 75 mg of venlafaxine for 4 weeks. DUE was defined as the interval between the onset of the index major depressive episode and the start of pharmacotherapy. The Depression and Somatic Symptoms Scale (DSSS), composed of the depression subscale (DS) and the somatic subscale (SS), was used. The SS included the pain subscale (PS) and the nonpain somatic subscale (NPSS). Multiple linear regressions were used to test the impacts of DUE on the improvement percentages (IPs) of depression and somatic symptoms. Eighty-five subjects completed the 4-week treatment. The IPs of the DS, SS, and NPSS were significantly negatively correlated with DUE. A shorter DUE was related to higher IPs. DUE was an independent factor, predicting the IPs of the DS, SS, and NPSS. DUE <1 month was the most powerful time-point to predict the IPs of the DS, SS, and NPSS. However, DUE was unable to predict the IP of the PS at all time-points. A shorter DUE might be one of the factors related to greater improvement of depression and somatic symptoms. DUE should be considered as an important factor when investigating the prognosis of depression and somatic symptoms.

Recessions and health: the impact of economic trends on air pollution in California.

PubMed

Davis, Mary E

2012-10-01

I explored the hypothesis that economic activity has a significant impact on exposure to air pollution and ultimately human health. I used county-level employment statistics in California (1980-2000), along with major regulatory periods and other controlling factors, to estimate local concentrations of the coefficient of haze, carbon monoxide, and nitrogen dioxide using a mixed regression model approach. The model explained between 33% and 48% of the variability in air pollution levels as estimated by the overall R(2) values. The relationship between employment measures and air pollution was statistically significant, suggesting that air quality improves during economic downturns. Additionally, major air quality regulations played a significant role in reducing air pollution levels over the study period. This study provides important evidence of a role for the economy in understanding human exposure to environmental pollution. The evidence further suggests that the impact of environmental regulations are likely to be overstated when they occur during recessionary periods, and understated when they play out during periods of economic growth.

Hydrological impacts of climate change on the Tejo and Guadiana Rivers

NASA Astrophysics Data System (ADS)

Kilsby, C. G.; Tellier, S. S.; Fowler, H. J.; Howels, T. R.

2007-05-01

A distributed daily rainfall runoff model is applied to the Tejo and Guadiana river basins in Spain and Portugal to simulate the effects of climate change on runoff production, river flows and water resource availability with results aggregated to the monthly level. The model is calibrated, validated and then used for a series of climate change impact assessments for the period 2070 2100. Future scenarios are derived from the HadRM3H regional climate model (RCM) using two techniques: firstly a bias-corrected RCM output, with monthly mean correction factors calculated from observed rainfall records; and, secondly, a circulation-pattern-based stochastic rainfall model. Major reductions in rainfall and streamflow are projected throughout the year; these results differ from those for previous studies where winter increases are projected. Despite uncertainties in the representation of heavily managed river systems, the projected impacts are serious and pose major threats to the maintenance of bipartite water treaties between Spain and Portugal and the supply of water to urban and rural regions of Portugal.

General outcomes and risk factors for minor and major amputations in Brazil.

PubMed

Leite, Jose O; Costa, Leandro O; Fonseca, Walter M; Souza, Debora U; Goncalves, Barbara C; Gomes, Gabriela B; Cruz, Lucas A; Nister, Nilder; Navarro, Tulio P; Bath, Jonathan; Dardik, Alan

2018-06-01

Objectives Major and minor amputations are associated with significant rates of mortality. However, little is known about the impact of unplanned redo-amputation during the same hospitalization on outcomes. The objectives of this study were to identify the risk factors associated with in-hospital mortality after both major and minor amputations as well as the results of unplanned redo-amputation on outcome. Methods Retrospective study of 342 consecutive patients who were treated with lower extremity amputation in Brazil between January 2013 and October 2014. Results The in-hospital mortality rate was higher in major compared to minor amputation (25.6% vs. 4.1%; p < 0.0001). Whereas chronic kidney disease, chronic obstructive pulmonary disease, and planned staged amputation predicted in-hospital mortality after major amputation, age, and congestive heart failure predicted mortality after minor amputation. The white blood cell count predicted in-hospital mortality following both major and minor amputation. However, postoperative infection predicted in-hospital mortality only following major amputation. Conclusions In-hospital mortality was high after major amputations. Unplanned redo-amputation was not a predictor of in-hospital mortality after major or minor amputation. Planned staged amputation was associated with reduced survival after major but not minor amputation. Postoperative infection predicted mortality after major amputation. Systemic diseases and postoperative white blood cell were associated with in-hospital mortality. This study suggests a possible link between a pro-inflammatory state and increased in-hospital mortality following amputation.

Factors affecting commercial application of embryo technologies in dairy cattle in Europe--a modelling approach.

PubMed

van Arendonk, Johan A M; Bijma, Piter

2003-01-15

Reproductive techniques have a major impact on the structure of breeding programmes, the rate of genetic gain and dissemination of genetic gain in populations. This manuscript reviews the impact of reproductive technologies on the underlying components of genetic gain and inbreeding with special reference to the role of female reproductive technology. Evaluation of alternative breeding schemes should be based on genetic gain while constraining inbreeding. Optimum breeding schemes can be characterised by: decreased importance of sib information; increased accuracy at the expense of intensity; and a factorial mating strategy. If large-scale embryo cloning becomes feasible, this will have a small impact on the rate of genetic gain but will have a large impact on the structure of breeding programmes.

Risk Factors for Death and Major Morbidity in Guatemalan Children with Acute Bacterial Meningitis.

PubMed

Olson, Daniel; Lamb, Molly M; Gaensbauer, James T; Todd, James K; Halsey, Neal A; Asturias, Edwin J

2015-07-01

Acute bacterial meningitis (ABM) remains a significant cause of pediatric illness and death in low and middle income countries. Identifying severity risk factors and predictive scores may guide interventions to reduce poor outcomes. Data from a prospective surveillance study for ABM in children aged 0-59 months admitted to 3 referral hospitals in Guatemala City from 2000 to 2007 were analyzed. ABM was defined as positive cerebrospinal fluid (CSF) culture, positive latex agglutination or CSF white blood cell greater than 100 cells/mL. Univariate and multivariate analyses of risk factors at hospital admission that predicted major morbidity or death during hospitalization were performed, along with validation of the predictive Herson-Todd score (HTS). Of 809 children with ABM episodes, 221 (27.3%) survived with major morbidity and 192 (23.7%) died. Among 383 children with nonmissing data, the most significant multivariate predictors for death or major morbidity were seizure [odds ratio (OR), 101.5; P < 0.001], CSF glucose less than 20 mg/dL (OR, 5.3; P = 0.0004), symptom duration more than 3 days (OR, 3.7; P = 0.003) and coma (OR, 6.3; P = 0.004). Of 221 children with a HTS greater than 5, 204 (92%) died or suffered major morbidity (OR, 10.3; P < 0.0001). ABM is a cause of considerable morbidity and mortality in Guatemala. Several clinical risk factors and the composite HTS predicted death or major morbidity. These predictors could help clinicians in low and middle income country guide medical care for ABM and could contribute to the public health impact assessment in preventing meningitis with vaccines.

Can Soft Drink Taxes Reduce Population Weight?

PubMed

Fletcher, Jason M; Frisvold, David; Tefft, Nathan

2010-01-01

Soft drink consumption has been hypothesized as one of the major factors in the growing rates of obesity in the US. Nearly two-thirds of all states currently tax soft drinks using excise taxes, sales taxes, or special exemptions to food exemptions from sales taxes to reduce consumption of this product, raise revenue, and improve public health. In this paper, we evaluate the impact of changes in state soft drink taxes on body mass index (BMI), obesity, and overweight. Our results suggest that soft drink taxes influence BMI, but that the impact is small in magnitude.

The objective impact of clinical peer review on hospital quality and safety.

PubMed

Edwards, Marc T

2011-01-01

Despite its importance, the objective impact of clinical peer review on the quality and safety of care has not been studied. Data from 296 acute care hospitals show that peer review program and related organizational factors can explain up to 18% of the variation in standardized measures of quality and patient safety. The majority of programs rely on an outmoded and dysfunctional process model. Adoption of best practices informed by the continuing study of peer review program effectiveness has the potential to significantly improve patient outcomes.

Biologics formulation factors affecting metal leachables from stainless steel.

PubMed

Zhou, Shuxia; Schöneich, Christian; Singh, Satish K

2011-03-01

An area of increasing concern and scientific scrutiny is the potential contamination of drug products by leachables entering the product during manufacturing and storage. These contaminants may either have a direct safety impact on the patients or act indirectly through the alteration of the physicochemical properties of the product. In the case of biotherapeutics, trace amounts of metal contaminants can arise from various sources, but mainly from contact with stainless steel (ss). The effect of the various factors, buffer species, solution fill volume per unit contact surface area, metal chelators, and pH, on metal leachables from contact with ss over time were investigated individually. Three major metal leachables, iron, chromium, and nickel, were monitored by inductively coupled plasma-mass spectrometry because they are the major components of 316L ss. Iron was primarily used to evaluate the effect of each factor since it is the most abundant. It was observed that each studied factor exhibited its own effect on metal leachables from contact with ss. The effect of buffer species and pH exhibited temperature dependence over the studied temperature range. The metal leachables decreased with the increased fill volume (mL) per unit contact ss surface area (cm(2)) but a plateau was achieved at approximately 3 mL/cm(2). Metal chelators produced the strongest effect in facilitating metal leaching. In order to minimize the metal leachables and optimize biological product stability, each formulation factor must be evaluated for its impact, to balance its risk and benefit in achieving the target drug product shelf life. © 2011 American Association of Pharmaceutical Scientists

What Makes Youth Harass Their Immigrant Peers? Understanding the Risk Factors

ERIC Educational Resources Information Center

Bayram Özdemir, Sevgi; Özdemir, Metin; Stattin, Håkan

2016-01-01

Immigrant youth are at risk of experiencing harassment in school; however, we have only limited understanding of what makes youth harass their peers on ground of their ethnic origin. To address this major limitation, we examined (a) whether youth's negative attitudes toward immigrants impact their engagement in ethnic harassment over time and (b)…

The Impact of State Enterprise Zones on Urban Manufacturing Establishments

ERIC Educational Resources Information Center

Greenbaum, Robert T.; Engberg, John B.

2004-01-01

Since the early 1980s, the vast majority of states have implemented enterprise zones. This paper analyzes urban zones in six states, examining the factors that states use to choose zone locations and the subsequent effect of the zones on business activity and employment. The source of outcome data is the U.S. Bureau of Census' longitudinal…

Diel activity patterns of major species of adult mosquitoes and ULV spraying impacts in St. John's County, Florida

USDA-ARS?s Scientific Manuscript database

Knowledge of daily activity patterns in adult mosquitoes can be used to determine the best time to apply adulticides for mosquito control. Many factors influence these activity patterns, including migration, hormonal cycles in the mosquito, hunger, and the need to lay eggs. In this study, FL scien...

Systems Impact: Issues and Trends in Improving School Outcomes for All Learners through Multitier Instructional Models

ERIC Educational Resources Information Center

Chard, David J.

2013-01-01

The majority of school districts implementing response to intervention use a systemwide, multitier model of delivery. This article describes the common features of multitier models and discusses the emerging evidence of their effectiveness. In addition, specific factors that schools should consider to enhance effective implementation of systemic,…

Factors Impacting the Construction Industry--and the Pipe Trades in Particular. Manpower Report 88-3.

ERIC Educational Resources Information Center

Lisack, J. P.; Shell, Kevin D.

This document contains a three-hour course on labor force and training considerations in the construction industry, especially as they relate to the pipe trades. The course is divided into eight major sections that cover the following topics: demographics; technological changes; the nation's labor force in general; the construction industry;…

The Resonance Factor: Probing the Impact of Video on Student Retention in Distance Learning

ERIC Educational Resources Information Center

Geri, Nitza

2012-01-01

Teaching and instructing is one of the challenging manifestations of informing, within which distance learning is considered harder than face-to-face instruction. Student retention is one of the major challenges of distance learning. Current innovative technologies enable widespread use of video lectures that may ease the loneliness of the…

Introduction: Commercialization of Academic Science and a New Agenda for Science Education

ERIC Educational Resources Information Center

Irzik, Gürol

2013-01-01

Certain segments of science are becoming increasingly commercialized. This article discusses the commercialization of academic science and its impact on various aspects of science. It also aims to provide an introduction to the articles in this special issue. I briefly describe the major factors that led to this phenomenon, situate it in the…

Factors Influencing Computer Anxiety and Its Impact on E-Learning Effectiveness: A Review of Literature

ERIC Educational Resources Information Center

Chien, Tien-Chen

2008-01-01

Computer is not only a powerful technology for managing information and enhancing productivity, but also an efficient tool for education and training. Computer anxiety can be one of the major problems that affect the effectiveness of learning. Through analyzing related literature, this study describes the phenomenon of computer anxiety,…

Predicting Personal Healthcare Management: Impact of Individual Characteristics on Patient Use of Health Information Technology

ERIC Educational Resources Information Center

Sandefer, Ryan Heath

2017-01-01

The use of health information and health information technology by consumers is a major factor in the current healthcare systems' effort to address issues related to quality, cost, and access. Patient engagement in the healthcare process through access to information related to diagnoses, procedures, and treatment has the potential to improve…

Future Scenarios in Communications. [Student's Guide.] Preparing for Tomorrow's World.

ERIC Educational Resources Information Center

Iozzi, Louis A.; And Others

The purpose of this module is to introduce students (grades 7-8) to the concept of change and factors influencing change. The module is composed of two major sections. Section 1 examines the development of the telephone system in the United States and introduces four futures forecasting techniques (Delphi probe, cross-impact matrix, trend…

Gender Role and Social Identifications: The Two Major Factors to Shape Turkish Women

ERIC Educational Resources Information Center

Erden-Imamoglu, Seval

2013-01-01

The process of being a woman starts with biological gender but it is shaped by learning the social gender roles. Besides social gender role; age, education, marriage, and motherhood supply social roles and attributions and they have an impact on women identification and their interpersonal relationships. The aim of the study is to investigate…

Human Factors beyond the Workplace: A Social Context for Robotics.

ERIC Educational Resources Information Center

Warnat, Winifred I.

This discussion of the influence of robotics on the individual and society addresses three major topics: (1) the current employment picture and future expectations; (2) developments in the robotics industry and their impact on the changing character of work; and (3) the implications of these changes for both society and the individual worker. The…

Exploring Student Perceptions of Retention Issues in a 3-Year Baccalaureate-Level Nursing Program

ERIC Educational Resources Information Center

Taulbee, Rebecca

2017-01-01

The nursing shortage, a major concern for the United States, has a multitude of causative factors. Nursing education has been tasked with helping to decrease the shortage of qualified registered nurses. Poor retention of nursing students in higher education is impacting the number of qualified nurses entering the workforce. Nursing education has…

Depressive Symptoms among College Students: An Assessment of the Influence of Environmental Factors on Retention Outcomes

ERIC Educational Resources Information Center

Mudric, Mary Beth

2012-01-01

Depressive symptoms among college students have major implications for higher education institutions across the country. First-year college students are particularly susceptible to the various impacts that the college experience may produce during the transitional first year of college. The effects of depressive symptoms among college students in…

Sibling rivalry: competition between Pol X family members in V(D)J recombination and general double strand break repair.

PubMed

Nick McElhinny, Stephanie A; Ramsden, Dale A

2004-08-01

The nonhomologous end-joining pathway is a major means for repairing double-strand breaks (DSBs) in all mitotic cell types. This repair pathway is also the only efficient means for resolving DSB intermediates in V(D)J recombination, a lymphocyte-specific genome rearrangement required for assembly of antigen receptors. A role for polymerases in end-joining has been well established. They are a major factor in determining the character of repair junctions but, in contrast to 'core' end-joining factors, typically appear to have a subtle impact on the efficiency of end-joining. Recent work implicates several members of the Pol X family in end-joining and suggests surprising complexity in the control of how these different polymerases are employed in this pathway.

Contrasting cardiovascular mortality trends in Eastern Mediterranean populations: Contributions from risk factor changes and treatments.

PubMed

Critchley, Julia; Capewell, Simon; O'Flaherty, Martin; Abu-Rmeileh, Niveen; Rastam, Samer; Saidi, Olfa; Sözmen, Kaan; Shoaibi, Azza; Husseini, Abdullatif; Fouad, Fouad; Ben Mansour, Nadia; Aissi, Wafa; Ben Romdhane, Habiba; Unal, Belgin; Bandosz, Piotr; Bennett, Kathleen; Dherani, Mukesh; Al Ali, Radwan; Maziak, Wasim; Arık, Hale; Gerçeklioğlu, Gül; Altun, Deniz Utku; Şimşek, Hatice; Doganay, Sinem; Demiral, Yücel; Aslan, Özgür; Unwin, Nigel; Phillimore, Peter; Achour, Nourredine; Aissi, Waffa; Allani, Riadh; Arfa, Chokra; Abu-Kteish, Heidar; Abu-Rmeileh, Niveen; Al Ali, Radwan; Altun, Deniz; Ahmad, Balsam; Arık, Hale; Aslan, Özgür; Beltaifa, Latifa; Ben Mansour, Nadia; Bennett, Kathleen; Ben Romdhane, Habiba; Ben Salah, Nabil; Collins, Marissa; Critchley, Julia; Capewell, Simon; Dherani, Mukesh; Demiral, Yücel; Doganay, Sinem; Elias, Madonna; Ergör, Gül; Fadhil, Ibtihal; Fouad, Fouad; Gerçeklioğlu, Gül; Ghandour, Rula; Göğen, Sibel; Husseini, Abdullatif; Jaber, Samer; Kalaca, Sibel; Khatib, Rana; Khatib, Rasha; Koudsie, Saer; Kilic, Bülent; Lassoued, Olfa; Mason, Helen; Maziak, Wasim; Mayaleh, Maher Abou; Mikki, Nahed; Moukeh, Ghmaez; Flaherty, Martin O; Phillimore, Peter; Rastam, Samer; Roglic, Gojka; Saidi, Olfa; Saatli, Gül; Satman, Ilhan; Shoaibi, Azza; Şimşek, Hatice; Soulaiman, Nesrien; Sözmen, Kaan; Tlili, Faten; Unal, Belgin; Unwin, Nigel; Yardim, Nazan; Zaman, Shahaduz

2016-04-01

Middle income countries are facing an epidemic of non-communicable diseases, especially coronary heart disease (CHD). We used a validated CHD mortality model (IMPACT) to explain recent trends in Tunisia, Syria, the occupied Palestinian territory (oPt) and Turkey. Data on populations, mortality, patient numbers, treatments and risk factor trends from national and local surveys in each country were collated over two time points (1995-97; 2006-09); integrated and analysed using the IMPACT model. Risk factor trends: Smoking prevalence was high in men, persisting in Syria but decreasing in Tunisia, oPt and Turkey. BMI rose by 1-2 kg/m(2) and diabetes prevalence increased by 40%-50%. Mean systolic blood pressure and cholesterol levels increased in Tunisia and Syria. Mortality trends: Age-standardised CHD mortality rates rose by 20% in Tunisia and 62% in Syria. Much of this increase (79% and 72% respectively) was attributed to adverse trends in major risk factors, occurring despite some improvements in treatment uptake. CHD mortality rates fell by 17% in oPt and by 25% in Turkey, with risk factor changes accounting for around 46% and 30% of this reduction respectively. Increased uptake of community treatments (drug treatments for chronic angina, heart failure, hypertension and secondary prevention after a cardiac event) accounted for most of the remainder. CHD death rates are rising in Tunisia and Syria, whilst oPt and Turkey demonstrate clear falls, reflecting improvements in major risk factors with contributions from medical treatments. However, smoking prevalence remains very high in men; obesity and diabetes levels are rising dramatically. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Quantifying the influence of natural and socioeconomic factors and their interactive impact on PM2.5 pollution in China.

PubMed

Yang, Dongyang; Wang, Xiaomin; Xu, Jianhua; Xu, Chengdong; Lu, Debin; Ye, Chao; Wang, Zujing; Bai, Ling

2018-06-04

PM 2.5 pollution is an environmental issue caused by multiple natural and socioeconomic factors, presenting with significant spatial disparities across mainland China. However, the determinant power of natural and socioeconomic factors and their interactive impact on PM 2.5 pollution is still unclear. In the study, the GeogDetector method was used to quantify nonlinear associations between PM 2.5 and potential factors. This study found that natural factors, including ecological environments and climate, were more influential than socioeconomic factors, and climate was the predominant factor (q = 0.56) in influencing PM 2.5 pollution. Among all interactions of the six influencing factors, the interaction of industry and climate had the largest influence (q = 0.66). Two recognized major contaminated areas were the Tarim Basin in the northwest region and the eastern plain region; the former was mainly influenced by the warm temperate arid climate and desert, and the latter was mainly influenced by the warm temperate semi-humid climate and multiple socioeconomic factors. The findings provided an interpretation of the influencing mechanisms of PM 2.5 pollution, which can contribute to more specific policies aimed at successful PM 2.5 pollution control and abatement. Copyright © 2018 Elsevier Ltd. All rights reserved.

Effective Factors in Marital Satisfaction in Perspective of Iranian Women and Men: A systematic review.

PubMed

Zaheri, Farzaneh; Dolatian, Mahrokh; Shariati, Mohammad; Simbar, Masoomeh; Ebadi, Abbas; Azghadi, Seyede Batool Hasanpoor

2016-12-01

One of the most important factors and determinants of mental health, emotional stability of couples and successful marriage is marital satisfaction, a state that in most cases, males and females are satisfied with each other and their marriage. This review was conducted to survey the effective factors on marital satisfaction in view of Iranian men and women. This systematic review surveys published articles from 2005 to 2015. First, scientific databases such as Pubmed/Medline, Scopus, Elsevier, Cochran library, Springer, Scientific Information Database (SID), IranMedex, Magiran and Medlib were searched using relevant key words and phrases. All published peer-reviewed articles studied exploring associations between marital satisfaction and effective factors were considered for inclusion. According to results, the spiritual and religious, sexual and interpersonal factors, communication and interaction factors and mental health had positive impact on marital satisfaction in the vast majority of studies. Also in most articles, impact of some socio-demographic factors such as occupation, length of marriage, age, Number of children, economic factor and income had been emphasized. In mate selection, it is necessary to note various criteria, including religious matters, moral, mental health, communication skills and sexual factor and action through education, counseling and treatment if there is problem.

Effective Factors in Marital Satisfaction in Perspective of Iranian Women and Men: A systematic review

PubMed Central

Zaheri, Farzaneh; Dolatian, Mahrokh; Shariati, Mohammad; Simbar, Masoomeh; Ebadi, Abbas; Azghadi, Seyede Batool Hasanpoor

2016-01-01

Introduction One of the most important factors and determinants of mental health, emotional stability of couples and successful marriage is marital satisfaction, a state that in most cases, males and females are satisfied with each other and their marriage. This review was conducted to survey the effective factors on marital satisfaction in view of Iranian men and women. Methods This systematic review surveys published articles from 2005 to 2015. First, scientific databases such as Pubmed/Medline, Scopus, Elsevier, Cochran library, Springer, Scientific Information Database (SID), IranMedex, Magiran and Medlib were searched using relevant key words and phrases. All published peer-reviewed articles studied exploring associations between marital satisfaction and effective factors were considered for inclusion. Results According to results, the spiritual and religious, sexual and interpersonal factors, communication and interaction factors and mental health had positive impact on marital satisfaction in the vast majority of studies. Also in most articles, impact of some socio-demographic factors such as occupation, length of marriage, age, Number of children, economic factor and income had been emphasized. Conclusion In mate selection, it is necessary to note various criteria, including religious matters, moral, mental health, communication skills and sexual factor and action through education, counseling and treatment if there is problem. PMID:28163850

Quantifying the impacts of climatic trend and fluctuation on crop yields in northern China.

PubMed

Qiao, Jianmin; Yu, Deyong; Liu, Yupeng

2017-10-01

Climate change plays a critical role in crop yield variations, which has attracted a great deal of concern worldwide. However, the mechanisms of how climatic trend and fluctuations affect crop yields are not well understood and need to be further investigated. Thus, using the GIS-based Environmental Policy Integrated Climate (EPIC) model, we simulated the yields of major crops (i.e., wheat, maize, and rice) and evaluated the impacts of climatic factors on crop yields in the Agro-Pastoral Transitional Zone (APTZ) of northern China between 1980 and 2010. The partial least squares regression model was used to assess the contribution rates of climatic factors (i.e., precipitation, photosynthetically active radiation (PAR), minimum temperature (T min ), maximum temperature (T max )) to the variation of crop yields. The Breaks for Additive Season and Trend (BFAST) model was adopted to decompose the climate factors into trend and fluctuation components, and the relative contributions of climate trend and fluctuation were then evaluated. The results indicated that the contributions of climatic factors to yield variations of wheat, maize, and rice were 31.7, 37.7, and 23.1%, respectively. That is, climate change had larger impacts on maize than wheat and rice. More cultivated areas were significantly and positively correlated with precipitation than with other climatic factors due to the limited precipitation in the APTZ. Also, climatic trend component had positive impacts on crop yields in the whole region, whereas the climate fluctuation was associated mainly with the areas where the crop yields decreased. This study helps improve our understanding of the mechanisms of climate change impacts on crop yields, and provides useful scientific information for designing regional-scale strategies of adaptation to climate change.

Master's level education in Jordan: a qualitative study of key motivational factors and perceived impact on practice.

PubMed

Zahran, Zainab

2013-09-01

To explore key motivational factors of Jordanian nurses to undertake a Master's degree and explore perceived impact on practice. In Jordan, there are postgraduate educational programmes offering a Master's degree in clinical nursing for registered nurses. These programmes are intended to prepare nurses to practise at an advanced level as potential clinical nurse specialists. Little is known about the motivation of nurses to undertake such Master's degree preparation programmes and their perceived impact on practice. Using an ethnographic design, narratives from semi-structured interviews with participants (n=37) from five Jordanian hospitals and two public universities were collected and thematically analysed. Four main themes emerged from the data: self development; broadening career opportunities; developing practice; and the perceived impact of Master's level nurses on practice. The majority of Jordanian nurses chose to undertake a Master's degree because of a desire for self and practice development. The majority of participants referred to M-level nurses in terms of knowledge transfer, highlighting their clinical teaching and in-service education activities. M-level nurses were also associated with managerial and supervisory roles in clinical practice. Controversy over the impact of M-level nurses in enhancing patient care is not limited to the Jordanian setting. Future research needs to focus on comparative studies between nurses with M-level qualifications and experienced nurses without either M-level qualifications or specialist courses to establish if there is any significant relationship between practice performance and educational preparation and experience. Evaluation research could be undertaken for the purpose of developing measurable and observable criteria related to educational and skill based outcomes. Copyright © 2012 Elsevier Ltd. All rights reserved.

Including impacts of particulate emissions on marine ecosystems in life cycle assessment: the case of offshore oil and gas production.

PubMed

Veltman, Karin; Huijbregts, Mark A J; Rye, Henrik; Hertwich, Edgar G

2011-10-01

Life cycle assessment is increasingly used to assess the environmental performance of fossil energy systems. Two of the dominant emissions of offshore oil and gas production to the marine environment are the discharge of produced water and drilling waste. Although environmental impacts of produced water are predominantly due to chemical stressors, a major concern regarding drilling waste discharge is the potential physical impact due to particles. At present, impact indicators for particulate emissions are not yet available in life cycle assessment. Here, we develop characterization factors for 2 distinct impacts of particulate emissions: an increased turbidity zone in the water column and physical burial of benthic communities. The characterization factor for turbidity is developed analogous to characterization factors for toxic impacts, and ranges from 1.4 PAF (potentially affected fraction) · m(3) /d/kg(p) (kilogram particulate) to 7.0 x 10³ [corrected] for drilling mud particles discharged from the rig. The characterization factor for burial describes the volume of sediment that is impacted by particle deposition on the seafloor and equals 2.0 × 10(-1) PAF · m(3) /d/kg(p) for cutting particles. This characterization factor is quantified on the basis of initial deposition layer characteristics, such as height and surface area, the initial benthic response, and the recovery rate. We assessed the relevance of including particulate emissions in an impact assessment of offshore oil and gas production. Accordingly, the total impact on the water column and on the sediment was quantified based on emission data of produced water and drilling waste for all oil and gas fields on the Norwegian continental shelf in 2008. Our results show that cutting particles contribute substantially to the total impact of offshore oil and gas production on marine sediments, with a relative contribution of 55% and 31% on the regional and global scale, respectively. In contrast, the contribution of particulate emissions to the total impact on the marine water column is of minor importance. We conclude that particles are an important stressor in marine ecosystems, particularly for marine sediment, and particulate emissions should therefore be included in a (life cycle) impact assessment of offshore oil and gas production. Copyright © 2011 SETAC.

Impact of Environmental Factors on the Regulation of Cyanotoxin Production

PubMed Central

Boopathi, Thangavelu; Ki, Jang-Seu

2014-01-01

Cyanobacteria are capable of thriving in almost all environments. Recent changes in climatic conditions due to increased human activities favor the occurrence and severity of harmful cyanobacterial bloom all over the world. Knowledge of the regulation of cyanotoxins by the various environmental factors is essential for effective management of toxic cyanobacterial bloom. In recent years, progress in the field of molecular mechanisms involved in cyanotoxin production has paved the way for assessing the role of various factors on the cyanotoxin production. In this review, we present an overview of the influence of various environmental factors on the production of major group of cyanotoxins, including microcystins, nodularin, cylindrospermopsin, anatoxins and saxitoxins. PMID:24967641

Geographical Detector-Based Identification of the Impact of Major Determinants on Aeolian Desertification Risk

PubMed Central

Du, Ziqiang; Xu, Xiaoming; Zhang, Hong; Wu, Zhitao; Liu, Yong

2016-01-01

Arid and semi-arid areas in North China are facing the challenge of a rising aeolian desertification risk (ADR) due to the intertwined effects of complex natural processes and intensified anthropogenic activities. An accurate quantitative assessment of the relationship between ADR and its determinants is beneficial for understanding the driving mechanisms of aeolian desertification and for controlling future desertification. Previous studies have failed to quantify the relative role of determinants driving ADR and have been limited in assessing their interactive impacts. In this study, a spatial variance analysis-based geographical detector methodology is used to quantify the effects of geological, physical, and human factors on the occurrence of ADR in an area characterized by mountains and hills in northern China. It is found that soil type, precipitation, and wind velocity are the major determinants of ADR, which implies that geological and physical elements (e.g., soil attribute) and climatic factors (e.g., precipitation and wind velocity) rather than human activities have played a greater role in the incidence of ADR. Particularly, the results show that the interaction of various determinants causes significant non-linearly enhanced impacts on the ADR. The findings of our study will assist local inhabitants and policy makers in developing measures for wind prevention and sand control to mitigate the effects of desertification in the region. PMID:26987114

Geographical Detector-Based Identification of the Impact of Major Determinants on Aeolian Desertification Risk.

PubMed

Du, Ziqiang; Xu, Xiaoming; Zhang, Hong; Wu, Zhitao; Liu, Yong

2016-01-01

Arid and semi-arid areas in North China are facing the challenge of a rising aeolian desertification risk (ADR) due to the intertwined effects of complex natural processes and intensified anthropogenic activities. An accurate quantitative assessment of the relationship between ADR and its determinants is beneficial for understanding the driving mechanisms of aeolian desertification and for controlling future desertification. Previous studies have failed to quantify the relative role of determinants driving ADR and have been limited in assessing their interactive impacts. In this study, a spatial variance analysis-based geographical detector methodology is used to quantify the effects of geological, physical, and human factors on the occurrence of ADR in an area characterized by mountains and hills in northern China. It is found that soil type, precipitation, and wind velocity are the major determinants of ADR, which implies that geological and physical elements (e.g., soil attribute) and climatic factors (e.g., precipitation and wind velocity) rather than human activities have played a greater role in the incidence of ADR. Particularly, the results show that the interaction of various determinants causes significant non-linearly enhanced impacts on the ADR. The findings of our study will assist local inhabitants and policy makers in developing measures for wind prevention and sand control to mitigate the effects of desertification in the region.

Smoking and diabetes. Epigenetics involvement in osseointegration.

PubMed

Razzouk, Sleiman; Sarkis, Rami

2013-03-01

Bone quality is a poorly defined parameter for successful implant placement, which largely depends upon many environmental and genetic factors unique to every individual. Smoking and diabetes are among the environmental factors that most impact osseointegration. However, there is an inter-individual variability of bone response in smokers and diabetic patients. Recent data on gene-environment interactions highlight the major role of epigenetic changes to induce a specific phenotype. Histone acetylation and DNA methylation are the main events that occur and modulate the gene expression. In this paper, we emphasize the impact of epigenetics on diabetes and smoking and describe their significance in bone healing. Also, we underscore the importance of adopting a new approach in clinical management for implant placement by customizing the treatment according to the patient's specific characteristics.

Systematic review of factors affecting pharmaceutical expenditures.

PubMed

Mousnad, Mohamed Awad; Shafie, Asrul Akmal; Ibrahim, Mohamed Izham

2014-06-01

To systematically identify the main factors contributing to the increase in pharmaceutical expenditures. A systematic search of published studies was conducted utilising major widely used electronic databases using the search terms 'factors,' 'financing,' 'pharmaceutical,' and 'expenditures.' To be included, the studies needed to: (1) measure at least one of the following outcomes: total growth in pharmaceutical expenditures, price growth or quantity growth; (2) mention a clear method for analysing the impact of factors affecting the increases in drug expenditures; (3) be written in English. Nonprimary articles that were published only as an abstract, a review, a commentary or a letter were excluded. From a total of 2039 studies, only 25 were included in the full review. The main determinant categories that were identified in the review were factors related to price, utilisation, therapeutic choice, demand and health care system. The major cost drivers were found to be changes in drug quantities and therapies as well as new drugs. It is important for policymakers to understand pharmaceutical spending trends and the factors that influence them in order to formulate effective cost containment strategies and design optimum drug policy. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Groundwater flow and hydrogeochemical evolution in the Jianghan Plain, central China

NASA Astrophysics Data System (ADS)

Gan, Yiqun; Zhao, Ke; Deng, Yamin; Liang, Xing; Ma, Teng; Wang, Yanxin

2018-05-01

Hydrogeochemical analysis and multivariate statistics were applied to identify flow patterns and major processes controlling the hydrogeochemistry of groundwater in the Jianghan Plain, which is located in central Yangtze River Basin (central China) and characterized by intensive surface-water/groundwater interaction. Although HCO3-Ca-(Mg) type water predominated in the study area, the 457 (21 surface water and 436 groundwater) samples were effectively classified into five clusters by hierarchical cluster analysis. The hydrochemical variations among these clusters were governed by three factors from factor analysis. Major components (e.g., Ca, Mg and HCO3) in surface water and groundwater originated from carbonate and silicate weathering (factor 1). Redox conditions (factor 2) influenced the geogenic Fe and As contamination in shallow confined groundwater. Anthropogenic activities (factor 3) primarily caused high levels of Cl and SO4 in surface water and phreatic groundwater. Furthermore, the factor score 1 of samples in the shallow confined aquifer gradually increased along the flow paths. This study demonstrates that enhanced information on hydrochemistry in complex groundwater flow systems, by multivariate statistical methods, improves the understanding of groundwater flow and hydrogeochemical evolution due to natural and anthropogenic impacts.

Prevention and treatment of traumatic brain injury due to rapid-onset natural disasters.

PubMed

Regens, James L; Mould, Nick

2014-01-01

The prevention and treatment of traumatic brain injury (TBI) attributable to rapid-onset natural disasters is a major challenge confronting disaster preparedness planners and emergency medical personnel responding to those incidents. The kinetic energy released by rapid-onset natural disasters such as earthquakes, hurricanes or typhoons, and tornadoes can cause mild, moderate, or severe TBIs. As a result, neurotrauma is a major risk factor for mortality and morbidity outcomes within the spatial domain impacted by a rapid-onset natural disaster. This review article elucidates major challenges associated with immediate emergency medical response, long-term care, and prevention of post-event increases in pediatric TBIs because of child abuse when rapid-onset natural disasters occur.

Queen Quality and the Impact of Honey Bee Diseases on Queen Health: Potential for Interactions between Two Major Threats to Colony Health

PubMed Central

Amiri, Esmaeil; Strand, Micheline K.; Rueppell, Olav; Tarpy, David R.

2017-01-01

Western honey bees, Apis mellifera, live in highly eusocial colonies that are each typically headed by a single queen. The queen is the sole reproductive female in a healthy colony, and because long-term colony survival depends on her ability to produce a large number of offspring, queen health is essential for colony success. Honey bees have recently been experiencing considerable declines in colony health. Among a number of biotic and abiotic factors known to impact colony health, disease and queen failure are repeatedly reported as important factors underlying colony losses. Surprisingly, there are relatively few studies on the relationship and interaction between honey bee diseases and queen quality. It is critical to understand the negative impacts of pests and pathogens on queen health, how queen problems might enable disease, and how both factors influence colony health. Here, we review the current literature on queen reproductive potential and the impacts of honey bee parasites and pathogens on queens. We conclude by highlighting gaps in our knowledge on the combination of disease and queen failure to provide a perspective and prioritize further research to mitigate disease, improve queen quality, and ensure colony health. PMID:28481294

Adverse reactions and other factors that impact subsequent blood donation visits.

PubMed

Custer, Brian; Rios, Jorge A; Schlumpf, Karen; Kakaiya, Ram M; Gottschall, Jerome L; Wright, David J

2012-01-01

The importance of adverse reactions in terms of donor safety recently has received significant attention, but their role in subsequent donation behavior has not been thoroughly investigated. Six REDS-II blood centers provided data for this analysis. Summary minor and major adverse reaction categories were created. The influence of adverse reactions on donation was examined in two ways: Kaplan-Meier curves were generated to determine the cumulative pattern of first return, and adjusted odds ratios (AORs) for demographic and other factors positively and negatively associated with return were estimated using multivariable logistic regression. Donors who had major reactions had longer times to return than donors with minor or no reactions. The AOR of returning for donors with major reactions was 0.32 (95% confidence interval [CI], 0.28-0.37) and with minor reactions 0.59 (95% CI, 0.56-0.62) when compared to donors who did not have reactions. Conversely, the most important factors positively associated with return were the number of donations in the previous year and increasing age. Subsequent return, whether a major, minor, or no reaction occurred, varied by blood center. Factors that are associated with the risk of having adverse reactions were not substantial influences on the return after adverse reactions. Having an adverse reaction leads to significantly lower odds of subsequent donation irrespective of previous donation history. Factors that have been associated with a greater risk of adverse reactions were not important positive or negative predictors of return after a reaction. © 2011 American Association of Blood Banks.

Confounding factors and genetic polymorphism in the evaluation of individual steroid profiling

PubMed Central

Kuuranne, Tiia; Saugy, Martial; Baume, Norbert

2014-01-01

In the fight against doping, steroid profiling is a powerful tool to detect drug misuse with endogenous anabolic androgenic steroids. To establish sensitive and reliable models, the factors influencing profiling should be recognised. We performed an extensive literature review of the multiple factors that could influence the quantitative levels and ratios of endogenous steroids in urine matrix. For a comprehensive and scientific evaluation of the urinary steroid profile, it is necessary to define the target analytes as well as testosterone metabolism. The two main confounding factors, that is, endogenous and exogenous factors, are detailed to show the complex process of quantifying the steroid profile within WADA-accredited laboratories. Technical aspects are also discussed as they could have a significant impact on the steroid profile, and thus the steroid module of the athlete biological passport (ABP). The different factors impacting the major components of the steroid profile must be understood to ensure scientifically sound interpretation through the Bayesian model of the ABP. Not only should the statistical data be considered but also the experts in the field must be consulted for successful implementation of the steroidal module. PMID:24764553

Conflict of interest in oncology publications: a survey of disclosure policies and statements.

PubMed

Kesselheim, Aaron S; Lee, Joy L; Avorn, Jerry; Servi, Amber; Shrank, William H; Choudhry, Niteesh K

2012-01-01

Disclosure of conflicts of interest in biomedical research is receiving increased attention. The authors sought to define current disclosure policies and how they relate to disclosure statements provided by authors in major oncology journals. The authors identified all oncology journals listed in the Thomson Institute for Scientific Information and sought their policies on conflict-of-interest disclosure. For a subset of journals with an Impact Factor >2.0, they catalogued the number and type of articles and the details of the published disclosures in all papers from the 2 most recent issues. Disclosure policies were provided by 112 of 131 journals (85%); 99 (88%) of these requested that authors disclose conflicts of interest (mean Impact Factor for these journals: 4.6), whereas the remaining 13 (12%) did not (mean Impact Factor: 2.9). Ninety-three journals (94%) required financial disclosure, and 42 (42%) also sought nonfinancial disclosures. For a subset of 52 higher-impact journals (Impact Factor >2.0), we reviewed 1734 articles and identified published disclosures in 51 journals (98%). Many of these journals (31 of 51, 61%) included some disclosure statement in >90% of their articles. Among 27 journals that published editorials/commentaries, only 14 (52%) included disclosures with such articles. There was no publication of any nonfinancial conflicts of interest in any article reviewed. Disclosure policies and the very definition of conflict of interest varied considerably among journals. Although most journals had some policy in this area, a substantial proportion did not publish disclosure statements consistently, with deficiencies particularly among editorials and commentaries. Copyright © 2011 American Cancer Society.

Tobacco Taxes in the Southeastern US States: Views from Former Legislators

PubMed Central

Berg, Carla J.; Solomon, Madeleine; Barkley, Amy; Bailey, Eric; Goodwin, Sherell Brown; Kegler, Michelle C.

2015-01-01

Objectives We examine influences on southeastern state legislators’ actions related to tobacco tax increases. Methods In 2014, we interviewed 26 former state legislators in southeastern states via phone. Results Themes regarding factors impeding increasing tobacco taxes included: tobacco's legacy in the South, protecting vulnerable populations from increased cigarette costs, concern about economic impact, opposing “sin” taxes, concern about impact on reelection, and perceptions that constituents oppose all taxes. The major theme in support of increasing tobacco taxes was health concern. Prior attempts at passing legislation resulted in political leveraging, deal-making, or compromising. Conclusions Legislators’ misperceptions of constituent opposition and impact on economy, among other impediments to increased tobacco taxes, must be addressed. PMID:26236755

[Medical and sanitary conditions of life activities of sea craft crew (review of literature)].

PubMed

Kubasov, R V; Lupachev, V V; Kubasova, E D

2016-08-01

The article characterizes sea work conditions under which crew-members carry occupational activitie's during the sail. Negative factors influencing health of crew members are listed. Among these factors, the major influence is caused by physical (noise, vibration, mechanical impacts, ionizing radiation varying in frequency), chemical, climate and.geographic, social an psychologic factors. Conclusion is that extreme work conditions of sailing staffers cause overstrain of adaptation systems, disorders of regulation fuctions, worsen health state and induce disablement. Within a system of medical care.for water transport workers, necessity is to have complex accounting of occupational hazards for more qualitative and safe work conditions.

Sociodemographic Antecedent Validators of Suicidal Behavior: A Review of Recent Literature.

PubMed

Conejero, Ismael; Lopez-Castroman, Jorge; Giner, Lucas; Baca-Garcia, Enrique

2016-10-01

Suicidal behavior and its prevention constitute a major public health issue. Etiology of suicidal behavior is multifactorial. Whereas current research is mostly focused on clinical and biological risk factors, the sociodemographic risk factors for suicidal behavior, first highlighted by Durkheim, have received less attention. Besides the well-known impact of age and gender, sociodemographic variables such as marital and parental status, education, occupation, income, employment status, religion, migration or minority status, and sexual orientation are repeatedly reported to play an important role in suicidal behavior. This narrative review aimed to summarize recent research on sociodemographic risk factors for suicidal behavior and to elicit possible implications for suicide prevention.

The prevalence and impact of risk factors for ethnic differences in loneliness

PubMed Central

El Fakiri, Fatima

2016-01-01

Background: Previous studies have demonstrated that loneliness is more frequently present in citizens of ethnic minority groups than in natives. The current study investigates whether ethnic differences in emotional and social loneliness between Moroccan, Turkish, Surinamese and Dutch adults living in the Netherlands are due to ethnic differences in the presence and/or impact of an array of possible risk factors, such as partnership, health and socioeconomic status. Methods: The data were collected in 2012 as a part of a general health questionnaire of the Public Health Services in the four major cities of the Netherlands, containing 20.047 Dutch, 1.043 Moroccan, 1.197 Turkish and 1.900 Surinamese respondents. Results: Structural equation models showed that ethnic differences in emotional and social loneliness can be ascribed to ethnic differences in the prevalence and impact of several risk factors. Main findings were that all three ethnic minority groups reported feeling less healthy and more discriminated against than the Dutch group, which was related to increased loneliness. Perceived financial difficulties and people in the neighbourhood not getting along had more impact on feelings of loneliness for the Turkish group than loneliness for the other ethnic groups. Furthermore, members of the Turkish group were found more at risk to feel anxious or depressed, which was in turn related to increased loneliness. Conclusions: Policy makers are encouraged to develop multifaceted prevention strategies concerning those risk factors that are most changeable, thereby focusing per risk factor on those ethnic groups for which it is an important contribution to loneliness. PMID:27497438

Vision impairment and major causes of vision loss impacts on vision-specific functioning independent of socioeconomic factors.

PubMed

Chiang, Peggy P C; Zheng, Yingfeng; Wong, Tien Y; Lamoureux, Ecosse L

2013-02-01

To quantify the eye disease-specific impact of unilateral and bilateral vision impairment (VI) on vision-specific functioning (VF). The Singapore Indian Eye population-based study. Ethnic Indians older than 40 years of age living in Singapore. Participants underwent standardized ophthalmic assessments for VI and blindness, defined using presenting visual acuity (United States definition). Sociodemographic data were recorded using a standardized questionnaire. Rasch analysis was used to validate the Visual Function Index 11 and to determine its psychometric properties. The major causes of VI (i.e., cataract, refractive error, age-related macular degeneration, diabetic retinopathy [DR], and glaucoma) were determined by ophthalmologists on examination. Multivariate linear regression analysis was performed to assess the impact of VI on the overall VF Rasch score. Vision-specific functioning. Three thousand three hundred ninety-six persons were analyzed. Participants with VI had a systematic reduction in VF score compared with those with normal vision in both eyes, ranging from -11.2% normal vision in one eye and low vision in the other eye (95% confidence interval [CI], -12.2% to -10.3%; P<0.001), to -12.7% blindness in one eye and normal vision in the other eye (CI, -15.1% to -10.4%; P<0.001), to -19.4% low vision in both eyes (CI, -20.8% to -18.1%; P<0.001), to -52.9% blindness in one eye and low vision in other eye (CI, -55.3% to -50.4%; P<0.001), to -77.2% blindness in both eyes (CI, -82.4% to 72.0%; P<0.001). The impact of VI on VF score varied across different major causes of vision loss, regardless of socioeconomic factors. Vision impairment attributed to cataract in one or both eyes had a significant decrease in VF score by 17.7% and 22.3%, respectively, compared with those with normal vision in both eyes (P<0.001). The impact of unilateral and bilateral VI on VF score was greater in participants with glaucoma (32.2% in unilateral cases and 35.9% in bilateral cases; P<0.001) and DR (29.4% in unilateral cases and 33.3% in bilateral cases; P<0.001). Vision impairment and major age-related eye diseases such as cataract, DR, and glaucoma are associated significantly with worse deterioration in VF, regardless of education level, literacy adequacy, or immigration pattern. Glaucoma and DR seemed to have a greater negative impact on VF score compared with cataract. This study highlights the importance of disease-specific interventions in reducing the adverse impact of VI on daily activities. Copyright © 2013 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.

The dynamics of fresh fruit and vegetable pricing in the supermarket channel.

PubMed

McLaughlin, Edward W

2004-09-01

This paper explains the major factors that contribute to the complicated price formation process, as several levels, of fresh fruit and vegetables in the US. Several factors are explored: marketing channels, market structure changes, pricing techniques and promotional impacts, retail responses to supply changes, and price versus value. The paper illustrates with recent examples and research findings that the fresh produce system is dynamic and that simplistic solutions to complex problems are not likely. The paper finishes by suggesting some areas for needed additional research.

Thermal and energy battery management optimization in electric vehicles using Pontryagin's maximum principle

NASA Astrophysics Data System (ADS)

Bauer, Sebastian; Suchaneck, Andre; Puente León, Fernando

2014-01-01

Depending on the actual battery temperature, electrical power demands in general have a varying impact on the life span of a battery. As electrical energy provided by the battery is needed to temper it, the question arises at which temperature which amount of energy optimally should be utilized for tempering. Therefore, the objective function that has to be optimized contains both the goal to maximize life expectancy and to minimize the amount of energy used for obtaining the first goal. In this paper, Pontryagin's maximum principle is used to derive a causal control strategy from such an objective function. The derivation of the causal strategy includes the determination of major factors that rule the optimal solution calculated with the maximum principle. The optimization is calculated offline on a desktop computer for all possible vehicle parameters and major factors. For the practical implementation in the vehicle, it is sufficient to have the values of the major factors determined only roughly in advance and the offline calculation results available. This feature sidesteps the drawback of several optimization strategies that require the exact knowledge of the future power demand. The resulting strategy's application is not limited to batteries in electric vehicles.

Congregationalist Richard Cordley and the Impact of New England Cultural Imperialism in Kansas, 1857-1904

ERIC Educational Resources Information Center

Wilson, Nathan

2004-01-01

As a major social force throughout the nineteenth century, religion proved an important factor in the settlement of the American West. Yet the idea of a religious figure as a western hero has never emerged in the popular culture adaptations of the Western, since the clergy are usually portrayed as gentle, "soft," or even somewhat…

Group Work and the Impact, if Any, of the Use of Google Applications for Education

ERIC Educational Resources Information Center

Maqbool, Jannat

2016-01-01

The use of group work in teaching practices has been well supported in educational theories however the researcher has experienced a number of issues or areas of concern in having students work in groups to complete a major assessment for a second year Project Management course at a leading polytechnic in New Zealand. Factors potentially…

Does Parenthood Strengthen a Traditional Household Division of Labor? Evidence from Sweden

ERIC Educational Resources Information Center

Dribe, Martin; Stanfors, Maria

2009-01-01

Parenthood is often considered a major factor behind gender differences in time allocation, especially between paid work and housework. This article investigates the impact of parenthood on men's and women's daily time use in Sweden and how it changed over the 1990s. The analysis is made using time diary data from the Multinational Time Use Survey…

Developing Meaning for Algebraic Procedures: An Exploration of the Connections Undergraduate Students Make between Algebraic Rational Expressions and Basic Number Properties

ERIC Educational Resources Information Center

Yantz, Jennifer

2013-01-01

The attainment and retention of later algebra skills in high school has been identified as a factor significantly impacting the postsecondary success of students majoring in STEM fields. Researchers maintain that learners develop meaning for algebraic procedures by forming connections to the basic number system properties. The present study…

Synergistic effects of the invasive Chinese tallow (Triadica sebifera) and climate change on aquatic amphibian survival

Treesearch

Daniel Saenz; Erin M. Fucik; Matthew A. Kwiatkowski

2013-01-01

Changes in climate and the introduction of invasive species are two major stressors to amphibians, although little is known about the interaction between these two factors with regard to impacts on amphibians. We focused our study on an invasive tree species, the Chinese tallow (Triadica sebifera), that annually sheds its leaves and produces leaf...

The Impact of Primary Education on School-to-Work Transitions for Young People in Rural Bolivia

ERIC Educational Resources Information Center

Punch, Samantha

2004-01-01

As in many parts of the majority world, primary education in rural Bolivia is constrained by a range of factors: poor teaching quality, lack of resources, limited infrastructure, inadequate teaching materials, and low wages for teachers. Furthermore, high rates of absenteeism, drop-out, repetition, and failure can be exacerbated by children's work…

Changing Conceptions of Reading: Literacy Learning Instruction. Seventh Yearbook of the American Reading Forum.

ERIC Educational Resources Information Center

Lumpkin, Donavon, Ed.; And Others

Articles in this yearbook contribute to a broad perspective of changing concepts of reading, each focusing attention on an area of major factors exercising current impact on reading and on the education of reading teachers. The articles and their authors are as follows: "Learning from Text" (T. Estes); "Untying the Gordian Knot" (W. Blanton and G.…

How Does Sensitivity Training of Health Care Workers Impact Patient Satisfaction?

ERIC Educational Resources Information Center

De Vinci, Katrina Marie

2010-01-01

Health care of the 21st century is undergoing major changes due to a myriad of social factors affecting every level of society. From financial desperation due to the high cost of health care to the increased awareness of a generation asking for better services, the importance of patient satisfaction is paramount. The Centers for Medicare and…

The Impact of Engineering Identification and Stereotypes on Undergraduate Women's Achievement and Persistence in Engineering

ERIC Educational Resources Information Center

Jones, Brett D.; Ruff, Chloe; Paretti, Marie C.

2013-01-01

Women almost always comprise a minority in engineering programs and a smaller percentage of women pursue engineering than other science and technology majors. The culture of engineering departments and negative stereotypes of women's engineering and mathematical ability have been identified as factors that inhibit women's entry into…

Mathematics, Race, and Space: An Investigation into the Construction of Mathematics Achievement Identities of Black Undergraduate Students at the University of Virginia

ERIC Educational Resources Information Center

McClain, Oren Leondus

2011-01-01

The purpose of this study was to investigate the phenomenon of the ways in which Black undergraduate students, majoring in mathematics intensive disciplines, at the University of Virginia construct mathematics achievement identities. Specifically, this study sought to identify and examine factors that impacted these students' identity construction…

Dissection of genetic factors underlying wheat kernel shape and size in an elite x nonadapted cross using a high density SNP linkage map

USDA-ARS?s Scientific Manuscript database

Wheat kernel shape and size has been under selection since early domestication. Kernel morphology is a major consideration in wheat breeding, as it impacts grain yield and quality. A population of 160 recombinant inbred lines (RIL), developed using an elite (ND 705) and a nonadapted genotype (PI 414...

A Non-Experimental Investigation on the Impact of Gender, Academic Skills and Computer Skills on Online Course Completion Rates

ERIC Educational Resources Information Center

Blanson, Constance D.

2013-01-01

Online students represent a growing majority of individuals who complete their academic studies via the use of a distance education. However, with so many distance learners not completing their online courses, identifying the factors that influence online course completion has became a widespread initiative within institutions of higher learning…

Using Course-Level Factors as Predictors of Online Course Outcomes: A Multi-Level Analysis at a US Urban Community College

ERIC Educational Resources Information Center

Wladis, Claire; Conway, Katherine; Hachey, Alyse C.

2017-01-01

Research has documented lower retention rates in online versus face-to-face courses. However, little research has focused on the impact of course-level characteristics (e.g. elective versus distributional versus major requirements; difficulty level; STEM status) on online course outcomes. Yet, focusing interventions at the course level versus the…

Approaching a Conceptual Understanding of Enzyme Kinetics and Inhibition: Development of an Active Learning Inquiry Activity for Prehealth and Nonscience Majors

ERIC Educational Resources Information Center

House, Chloe; Meades, Glen; Linenberger, Kimberly J.

2016-01-01

Presented is a guided inquiry activity designed to be conducted with prenursing students using an analogous system to help develop a conceptual understanding of factors impacting enzyme kinetics and the various types of enzyme inhibition. Pre- and postconceptual understanding evaluations and effectiveness of implementation surveys were given to…

Integrating Information Systems in a Major Decentralized International Organization. Volume 7.

DTIC Science & Technology

1987-12-01

deployment of information technology. Three key conflicting organizational forces were found to significantly impact the technical strategies : 1... strategy was modulated by three key conflicting organizational forces - autonomy, integration and evolution. A conceptual system architecture has been... organizational needs. The second part, "Gaining Strategic Advantage Through Composite Tnformation Systems," identifies critical success factors for the

Technology Enhanced Learning Environments for Closing the Gap in Student Achievement between Regions: Does It Work?

ERIC Educational Resources Information Center

Cakir, Hasan; Delialioglu, Omer; Dennis, Alan; Duffy, Thomas

2009-01-01

Student achievement gap between urban and suburban regions are a major issue in U.S. schools. Technology enhanced learning environments that support teaching and learning process with advanced technology may close this achievement gap. This paper examines the impact of student and school factors with an emphasis on schools' geographic location on…

A Conceptual Framework for the Analysis of Risk and Problem Behaviors: The Case of Adolescent Sexual Behavior

ERIC Educational Resources Information Center

Guilamo-Ramos; Vincent; Jaccard, James; Dittus, Patricia; Gonzalez, Bernardo; Bouris, Alida

2008-01-01

A framework for the analysis of adolescent problem behaviors was explicated that draws on five major theories of human behavior. The framework emphasizes intentions to perform behaviors and factors that influence intentions as well as moderate the impact of intentions on behavior. The framework was applied to the analysis of adolescent sexual risk…

Searching High and Searching Low, Searching East and Searching West: Looking for Trust in Teacher Education

ERIC Educational Resources Information Center

Townsend, Tony

2011-01-01

This paper considers what has been learned from reviewing the full set of papers in this special issue. It considers some of the major factors that have impacted on education and subsequently teacher education in recent times, namely rapid technological change and increasing globalisation and movement from one country to others, and then focuses…

Tryptophan–Kynurenine Metabolism as a Common Mediator of Genetic and Environmental Impacts in Major Depressive Disorder: The Serotonin Hypothesis Revisited 40 Years Later

PubMed Central

Oxenkrug, Gregory F.

2011-01-01

The original 1969 Lancet paper proposed, “in depression the activity of liver tryptophan-pyrrolase is stimulated by raised blood corticosteroids levels, and metabolism of tryptophan is shunted away from serotonin production, and towards kynurenine production.” Discovery of neurotropic activity of kynurenines suggested that up-regulation of the tryptophan-kynurenine pathway not only augmented serotonin deficiency but also underlined depression-associated anxiety, psychosis and cognitive decline. The present review of genetic and hormonal factors regulating kynurenine pathway of tryptophan metabolism suggests that this pathway mediates both genetic and environmental mechanisms of depression. Rate-limiting enzymes of kynurenine formation, tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO) are activated by stress hormones (TDO) and/or by pro-inflammatory cytokines (IDO). Simultaneous presence of high producers alleles of proinflammatory cytokines genes (e.g., interferon-gamma and tumor necrosis factor-alpha) determines the genetic predisposition to depression via up-regulation of IDO while impact of environmental stresses is mediated via hormonal activation of TDO. Tryptophan-kynurenine pathway represents a major meeting point of gene-environment interaction in depression and a new target for pharmacological intervention. PMID:20686200

Controlled release for crop and wood protection: Recent progress toward sustainable and safe nanostructured biocidal systems.

PubMed

Mattos, Bruno D; Tardy, Blaise L; Magalhães, Washington L E; Rojas, Orlando J

2017-09-28

We review biocide delivery systems (BDS), which are designed to deter or control harmful organisms that damage agricultural crops, forests and forest products. This is a timely topic, given the growing socio-economical concerns that have motivated major developments in sustainable BDS. Associated designs aim at improving or replacing traditional systems, which often consist of biocides with extreme behavior as far as their solubility in water. This includes those that compromise or pollute soil and water (highly soluble or volatile biocides) or those that present low bioavailability (poorly soluble biocides). Major breakthroughs are sought to mitigate or eliminate consequential environmental and health impacts in agriculture and silviculture. Here, we consider the most important BDS vehicles or carriers, their synthesis, the environmental impact of their constituents and interactions with the active components together with the factors that affect their rates of release such as environmental factors and interaction of BDS with the crops or forest products. We put in perspective the state-of-the-art nanostructured carriers for controlled release, which need to address many of the challenges that exist in the application of BDS. Copyright © 2017 Elsevier B.V. All rights reserved.

Global Rice Watch: Spatial-temporal dynamics, driving factors, and impacts of paddy rice agriculture in the world

NASA Astrophysics Data System (ADS)

Xiao, X.; Dong, J.; Zhang, G.; Xin, F.; Li, X.

2017-12-01

Paddy rice croplands account for more than 12% of the global cropland areas, and provide food to feed more than 50% of the world population. Spatial patterns and temporal dynamics of paddy rice croplands have changed remarkably in the past decades, driven by growing human population and their changing diet structure, land use (e.g., urbanization, industrialization), climate, markets, and technologies. In this presentation, we will provide a comprehensive review of our current knowledge on (1) the spatial patterns and temporal dynamics of paddy rice croplands from agricultural statistics data and remote sensing approaches; (2) major driving factors for the observed changes in paddy rice areas, including social, economic, climate, land use, markets, crop breeding technology, and farming technology; and (3) major impacts on atmospheric methane concentration, land surface temperature, water resources and use, and so on. We will highlight the results from a few case studies in China and monsoon Asia. We will also call for a global synthesis analysis of paddy rice agriculture, and invite researchers to join the effort to write and edit a book that provides comprehensive and updated knowledge on paddy rice agriculture.

Bio-Medical Factors and External Hazards in Space Station Design

NASA Technical Reports Server (NTRS)

Olling, E. H.

1966-01-01

The design of space-station configurations is influenced by many factors. Probably the most demanding and critical are the biomedical and external hazards requirements imposed to provide the proper environment and supporting facilities for the crew and the adequate protective measures necessary to provide a configuration'in which the crew can live and work efficiently in relative comfort and safety. The major biomedical factors, such as physiology, psychology, nutrition, personal hygiene, waste management, and recreation, all impose their own peculiar requirements. The commonality and integration of these requirements demand the utmost ingenuity and inventiveness be exercised in order to achieve effective configuration compliance. The relationship of biomedical factors for the internal space-station environment will be explored with respect to internal atmospheric constituency, atmospheric pressure levels, oxygen positive pressure, temperature, humidity, CO2 concentration, and atmospheric contamination. The range of these various parameters and the recommended levels for design use will be analyzed. Requirements and criteria for specific problem areas such as zero and artificial gravity and crew private quarters will be reviewed and the impact on the design of representative solutions will be presented. In the areas of external hazards, the impact of factors such as meteoroids, radiation, vacuum, temperature extremes, and cycling on station design will be evaluated. Considerations with respect to operational effectiveness and crew safety will be discussed. The impact of such factors on spacecraft design to achieve acceptable launch and reentry g levels, crew rotation intervals, etc., will be reviewed.

Comorbidity of PTSD, Major Depression, and Substance Use Disorder Among Adolescent Victims of the Spring 2011 Tornadoes in Alabama and Joplin, Missouri.

PubMed

Adams, Zachary W; Danielson, Carla Kmett; Sumner, Jennifer A; McCauley, Jenna L; Cohen, Joseph R; Ruggiero, Kenneth J

2015-01-01

The purpose of this study was twofold: (1) to estimate the prevalence of comorbid posttraumatic stress disorder (PTSD), major depressive episode (MDE), and substance use disorder (SUD); and (2) to identify risk factors for patterns of comorbidity among adolescents affected by disasters. A population-based sample of 2,000 adolescents (51% female; 71% Caucasian, 26% African American) aged 12 to 17 years (M = 14.5, SD = 1.7) and their parents was recruited from communities affected by the spring 2011 tornadoes in Alabama and Joplin, Missouri. Participants completed structured telephone interviews assessing demographic characteristics, impact of disaster, prior trauma history, Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV), symptoms of posttraumatic stress disorder (PTSD) and major depressive episode (MDE), and substance use disorder (SUD) symptoms. Prevalence estimates were calculated for PTSD + MDE, PTSD + SUD, MDE + SUD, and PTSD + MDE + SUD. Hierarchical logistic regression was used to identify risk factors for each comorbidity profile. Overall prevalence since the tornado was 3.7% for PTSD + MDE, 1.1% for PTSD + SUD, 1.0% for MDE + SUD, and 0.7% for PTSD + MDE + SUD. Girls were significantly more likely than boys to meet criteria for PTSD + MDE and MDE + SUD (ps < .05). Female gender, exposure to prior traumatic events, and persistent loss of services were significant risk factors for patterns of comorbidity. Parental injury was associated with elevated risk for PTSD + MDE. Adolescents should be evaluated for comorbid problems, including SUD, following disasters so that appropriate referrals to evidence-based treatments can be made. Results suggest that screening procedures to identify adolescents at risk for comorbid disorders should assess demographic characteristics (gender), impact of the disaster on the family, and adolescents' prior history of stressful events.

Clinical Factors and Postoperative Impact of Bile Leak After Liver Resection.

PubMed

Martin, Allison N; Narayanan, Sowmya; Turrentine, Florence E; Bauer, Todd W; Adams, Reid B; Stukenborg, George J; Zaydfudim, Victor M

2018-04-01

Despite technical advances, bile leak remains a significant complication after hepatectomy. The current study uses a targeted multi-institutional dataset to characterize perioperative factors that are associated with bile leakage after hepatectomy to better understand the impact of bile leak on morbidity and mortality. Adult patients in the 2014-2015 ACS NSQIP targeted hepatectomy dataset were linked to the ACS NSQIP PUF dataset. Bivariable and multivariable regression analyses were used to assess the associations between clinical factors and post-hepatectomy bile leak. Of 6859 patients, 530 (7.7%) had a postoperative bile leak. Proportion of bile leaks was significantly greater in patients after major compared to minor hepatectomy (12.6 vs. 5.1%, p < 0.001). The proportion of patients with bile leak was significantly greater in patients after major hepatectomy who had concomitant enterohepatic reconstruction (31.8 vs. 10.1%, p < 0.001). Postoperative mortality was significantly greater in patients with bile leaks (6.0 vs. 1.7%, p < 0.001). After adjusting for significant covariates, bile leak was independently associated with increased risk of postoperative morbidity (OR = 4.55; 95% CI 3.72-5.56; p < 0.001). After adjusting for significant effects of postoperative complications, liver failure, and reoperation (all p<0.001), bile leak was not independently associated with increased risk of postoperative mortality (p = 0.262). Major hepatectomy and enterohepatic biliary reconstruction are associated with significantly greater rates of bile leak after liver resection. Bile leak is independently associated with significant postoperative morbidity. Mitigation of bile leak is critical in reducing morbidity and mortality after liver resection.

[The reasons for the «space» of gerontology: the impact of the movements of the Earth and Moon on the performance of the human environment].

PubMed

Shapovalov, S N

2016-01-01

For future gerontological research specific interest are the research results obtained at the junction of Geophysics, astronomy, and biology, and existing links pointing to indicators of living objects with cosmophysical factors. The paper presents data on basic astronomical factors, potentially on a regular basis may cause gravitational effects on the biosphere as a living environment. Among these factors are movement of the Earth and Moon described is known in astronomy equations: the equation of the equinoxes, equation of time, as well as major perturbations from the Sun (evection, variation and annual inequality) inferred from the theory of lunar motion. Based on the amount of major perturbations from the Sun, the so-called λD-functions that are carried out to study the relationship between fluctuations of the so-called «computer time», the energy of solar radiation in the range of 605-607 nm, and the concentration of hemoglobin and red blood cells with major perturbations from the Sun. The resulting conclusion about the universal nature of the impact of the movements of the Moon and the Earth on the biosphere. The tables for the period from 01.01.2015 to 31.12.2016, with the calculated values λD functions that are potentially important for analyzing their association with temporal changes of various indicators of the body. The regularities obtained in the comparison of changes in various biomarkers with the course of values λD functions from tables, can be predictive in the study of the functioning of humans and the biosphere for astronomical periods. The research was carried out in Antarctica, where excluded the influence of artificial electromagnetic fields, st. Vostok (1998-1999) and st. Novolazarevskaya (2003-2004).

Economic costs of protistan and metazoan parasites to global mariculture.

PubMed

Shinn, A P; Pratoomyot, J; Bron, J E; Paladini, G; Brooker, E E; Brooker, A J

2015-01-01

Parasites have a major impact on global finfish and shellfish aquaculture, having significant effects on farm production, sustainability and economic viability. Parasite infections and impacts can, according to pathogen and context, be considered to be either unpredictable/sporadic or predictable/regular. Although both types of infection may result in the loss of stock and incur costs associated with the control and management of infection, predictable infections can also lead to costs associated with prophylaxis and related activities. The estimation of the economic cost of a parasite event is frequently complicated by the complex interplay of numerous factors associated with a specific incident, which may range from direct production losses to downstream socio-economic impacts on livelihoods and satellite industries associated with the primary producer. In this study, we examine the world's major marine and brackish water aquaculture production industries and provide estimates of the potential economic costs attributable to a range of key parasite pathogens using 498 specific events for the purposes of illustration and estimation of costs. This study provides a baseline resource for risk assessment and the development of more robust biosecurity practices, which can in turn help mitigate against and/or minimise the potential impacts of parasite-mediated disease in aquaculture.

Estimated impact of global population growth on future wilderness extent

NASA Astrophysics Data System (ADS)

Dumont, E.

2012-06-01

Wilderness areas in the world are threatened by the environmental impacts of the growing global human population. This study estimates the impact of birth rate on the future surface area of biodiverse wilderness and on the proportion of this area without major extinctions. The following four drivers are considered: human population growth (1), agricultural efficiency (2), groundwater drawdown by irrigation (3), and non-agricultural space used by humans (buildings, gardens, roads, etc.) (4). This study indicates that the surface area of biodiverse unmanaged land will reduce with about 5.4% between 2012 and 2050. Further, it indicates that the biodiverse land without major extinctions will reduce with about 10.5%. These percentages are based on a commonly used population trajectory which assumes that birth rates across the globe will reduce in a similar way as has occurred in the past in many developed countries. Future birth rate is however very uncertain. Plausible future birth rates lower than the expected rates lead to much smaller reductions in surface area of biodiverse unmanaged land (0.7% as opposed to 5.4%), and a reduction in the biodiverse land without major extinctions of about 5.6% (as opposed to 10.5%). This indicates that birth rate is an important factor influencing the quality and quantity of wilderness remaining in the future.

Choosing the right journal for your systematic review.

PubMed

Betini, Marluci; Volpato, Enilze S N; Anastácio, Guilherme D J; de Faria, Renata T B G; El Dib, Regina

2014-12-01

The importance of systematic reviews (SRs) as an aid to decision making in health care has led to an increasing interest in the development of this type of study. When selecting a target journal for publication, authors generally seek out higher impact factor journals. This study aimed to determine the percentage of scientific medical journals that publish SRs according to their impact factors (>2.63) and to determine whether those journals require tools that aim to improve SR reporting and meta-analyses. In our cross-sectional study showing how to choose the right journal for a SR, we selected and analysed scientific journals available in a digital library with a minimum Institute for Scientific Information impact factor of 2.63. We analysed 622 scientific journals, 435 (69.94%) of which publish SRs. Of those 435 journals, 135 (21.60%) provide instructions for authors that mention SRs. Three hundred journals (48.34%) do not discuss criteria for article acceptance in the instructions for authors section, but do publish SRs. Only 118 (27.00%) scientific journals require items to be reported in accordance with the specific SR reporting forms. The majority of the journals do not mention the acceptance of SRs in the instructions for authors section. Only a few journals require that SRs meet specific reporting guidelines, making interpretation of their findings across studies challenging. There is no correlation between the impact factor of the journal and its acceptance of SRs for publication. © 2014 John Wiley & Sons, Ltd.

[Reliability of a bibliometric tool used in France for hospital founding].

PubMed

Darmoni, Stefan J; Ladner, Joël; Devos, Patrick; Gehanno, Jean-François

2009-01-01

SIGAPS is a bibliometric score that aims at making an inventory, evaluating and promoting scientific publications of hospitals that perform research. It has become a major stake in France since it is one of the most important components of the MERRI (Mission Training, Research, Reference and Innovation) founding of hospitals. This score is based on the points attributed to the authors of articles published in journals indexed in Medline, according to the rank of the authors and the Impact Factor of the journal. to compare the reliability of the score when applying different way of computing it, and different weights for the rank or the Impact Factor. we computed the scores of all the physicians of a University Hospital, using the rules that are actually applied at the national level. We then used 4 different scenarios, with different weight given to the rank of authors or the Impact Factor. We compared the scores obtained by each author according to the different scenarios with the Spearman's rank and Pearson's correlation coefficients. The score is not significantly affected when no points are given to the fourth authors and above, when the last author get more points or to change the points according to the Impact Factor of the journal. The different scenarios do not lead to significant changes for the physicians' scores, and therefore for the cumulated score of the hospital. Despite the well known limits of bibliometric indicators, the SIGAPS score appears reliable to compare the hospitals for founding decisions.

Health impacts of chemical irritants used for crowd control: a systematic review of the injuries and deaths caused by tear gas and pepper spray.

PubMed

Haar, Rohini J; Iacopino, Vincent; Ranadive, Nikhil; Weiser, Sheri D; Dandu, Madhavi

2017-10-19

Chemical irritants used in crowd control, such as tear gases and pepper sprays, are generally considered to be safe and to cause only transient pain and lacrimation. However, there are numerous reports that use and misuse of these chemicals may cause serious injuries. We aimed to review documented injuries from chemical irritants to better understand the morbidity and mortality associated with these weapons. We conducted a systematic review using PRISMA guidelines to identify injuries, permanent disabilities, and deaths from chemical irritants worldwide between January 1, 1990 and March 15, 2015. We reviewed injuries to different body systems, injury severity, and potential risk factors for injury severity. We also assessed region, context and quality of each included article. We identified 31 studies from 11 countries. These reported on 5131 people who suffered injuries, two of whom died and 58 of whom suffered permanent disabilities. Out of 9261 total injuries, 8.7% were severe and required professional medical management, while 17% were moderate and 74.3% were minor. Severe injuries occurred to all body systems, with the majority of injuries impacting the skin and eyes. Projectile munition trauma caused 231 projectile injuries, with 63 (27%) severe injuries, including major head injury and vision loss. Potentiating factors for more severe injury included environmental conditions, prolonged exposure time, and higher quantities of chemical agent in enclosed spaces. Although chemical weapons may have a limited role in crowd control, our findings demonstrate that they have significant potential for misuse, leading to unnecessary morbidity and mortality. A nuanced understanding of the health impacts of chemical weapons and mitigating factors is imperative to avoiding indiscriminate use of chemical weapons and associated health consequences.

Pastoralists' knowledge and practices towards clinical bovine dermatophilosis in cattle herds of North-Central Nigeria: the associated factors, burden and economic impact.

PubMed

Alhaji, Nma Bida; Isola, Tajudeen Opeyemi

2018-02-01

Dermatophilosis is a contagious disease of high economic importance. The study assessed knowledge/awareness and clinical burden of and mitigation measures practised against clinical bovine dermatophilosis in pastoral herds of North-Central Nigeria and associated socio-cultural factors that predisposed to its occurrence in herds. A cross-sectional survey was conducted between October 2015 and September 2016. Questionnaires were administered on pastoralists and clinical assessment of cattle with gross pathological lesions indicative of dermatophilosis conducted. Associated economic impact was estimated. All 384 selected pastoralists participated in the survey. The majorities of nomadic (97.4%) and sedentary (68.2%) pastoralists significantly (p < 0.05) reported to have heard about dermatophilosis. Majorities of the sedentary (91.7%) and nomadic (97.4%) pastoralists mentioned the use antibiotics to manage the disease. Pastoralists in age group 70-79 years were more likely (OR 15.22; 95% CI 4.69, 49.34) to possess satisfactory knowledge about the disease. Culture of giving out cattle as gift or payment for dowry was more likely (OR 28.56; 95% CI 15.64, 52.12) to influence dermatophilosis occurrence in herds. Overall clinical dermatophilosis burden was 3.6% (95% CI 3.46, 3.80) and the annual economic impact was estimated at 908,463.9 USD. This study has given an idea to the status of pastoralists' levels of awareness about dermatophilosis in Nigeria, which can be harnessed by policy makers to develop its mitigation measures. Significant influence of pastoralists' socio-cultural activities on dermatophilosis occurrence in herds was identified. Surveillance and control programmes towards dermatophilosis that take these factors into consideration will be beneficial to the herders.

Student evaluations of their physics teachers: Evaluative bias and its relationship to classroom pedagogy and students' career aspirations

NASA Astrophysics Data System (ADS)

Potvin, Geoff

2013-04-01

Using data collected from a nationally-representative sample of college students, the evaluation of high school physics teachers by their students is examined. Confirming earlier work, student evaluations (of both male and female students) exhibit bias with respect to the gender of their teacher. Pedagogical practices that impact student evaluations are explored, but these factors do not change the gender bias effect. We also consider how this evaluative bias is affected by students' career intentions. Grouping students according to their career intentions (e.g. physics majors, engineering majors, and health/medical science majors) shows that physics and engineering majors exhibit this bias to the same extent as the general population, but health/medical science majors exhibit a bias with nearly twice the size as average. The implications of this research for our understanding of physics culture regarding stereotypes and students' gendered expectations of teacher behavior is discussed.

Inequalities and impact of socioeconomic-cultural factors in suicide rates across Italy.

PubMed

Pompili, Maurizio; Innamorati, Marco; Vichi, Monica; Masocco, Maria; Vanacore, Nicola; Lester, David; Serafini, Gianluca; Tatarelli, Roberto; De Leo, Diego; Girardi, Paolo

2011-01-01

Suicide is a major cause of premature death in Italy and occurs at different rates in the various regions. The aim of the present study was to provide a comprehensive overview of suicide in the Italian population aged 15 years and older for the years 1980-2006. Mortality data were extracted from the Italian Mortality Database. Mortality rates for suicide in Italy reached a peak in 1985 and declined thereafter. The different patterns observed by age and sex indicated that the decrease in the suicide rate in Italy was initially the result of declining rates in those aged 45+ while, from 1997 on, the decrease was attributable principally to a reduction in suicide rates among the younger age groups. It was found that socioeconomic factors underlined major differences in the suicide rate across regions. The present study confirmed that suicide is a multifaceted phenomenon that may be determined by an array of factors. Suicide prevention should, therefore, be targeted to identifiable high-risk sociocultural groups in each country.

The impact of serious mental illness on health and healthcare.

PubMed

Viron, Mark J; Stern, Theodore A

2010-01-01

Patients with serious mental illness (SMI; e.g., psychotic disorders and major mood disorders) die earlier, have more medical illnesses, and receive worse medical care than those in the general population. The aims of this article are to review the data on medical morbidity and mortality in those with SMI, to highlight the factors that lead to such disparities, and to discuss potential solutions to the problem. The authors reviewed the literature on medical morbidity and mortality in those with SMI. Adults with SMI in the United States die 25 years earlier than those in the general population; cardiovascular disease is responsible for the majority of this excess mortality, accounting for roughly 50%-60% of the deaths due to medical illness. Patient, provider, and system-level factors interact to contribute to poor health outcomes in people with SMI. Patients with SMI are losing many years of life to preventable and treatable medical illnesses. Solutions to the problem will require attention to patient, provider, and system-level factors.

Emotion regulation: exploring the impact of stress and sex

PubMed Central

Kinner, Valerie L.; Het, Serkan; Wolf, Oliver T.

2014-01-01

Emotion regulation is a major prerequisite for adaptive behavior. The capacity to regulate emotions is particularly important during and after the encounter of a stressor. However, the impact of acute stress and its associated neuroendocrine alterations on emotion regulation have received little attention so far. This study aimed to explore how stress-induced cortisol increases affect three different emotion regulation strategies. Seventy two healthy men and women were either exposed to a stressor or a control condition. Subsequently participants viewed positive and negative images and were asked to up- or down-regulate their emotional responses or simultaneously required to solve an arithmetic task (distraction). The factors stress, sex, and strategy were operationalized as between group factors (n = 6 per cell). Stress caused an increase in blood pressure and higher subjective stress ratings. An increase in cortisol was observed in male participants only. In contrast to controls, stressed participants were less effective in distracting themselves from the emotional pictures. The results further suggest that in women stress enhances the ability to decrease negative emotions. These findings characterize the impact of stress and sex on emotion regulation and provide initial evidence that these factors may interact. PMID:25431554

Impact of age on cardiovascular risk: implications for cardiovascular disease management.

PubMed

Tuomilehto, Jaakko

2004-05-01

Cardiovascular disease (CVD) represents a major global healthcare problem. The prevalence of this condition increases with age. As many countries around the world are experiencing an increase in the proportion of elderly people in the population, this raises serious issues for cardiac and cerebrovascular disease prevention and management. A wealth of data has established smoking, dyslipidemia, hypertension and type 2 diabetes as major risk factors for cardiac and cerebrovascular events. This article reviews the evidence that links these metabolic risk factors with an increased risk of complications, and assesses the data concerning how risk changes with age. This review also focuses on how these conditions can be optimally managed and whether treatment outcomes are affected by age. The current status of research is assessed and issues which remain to be resolved are highlighted.

Evolved-Lithology Clasts in Lunar Breccias: Relating Petrogenetic Diversity to Measured Water Content

NASA Technical Reports Server (NTRS)

Christoffersen, R.; Simon, J. J.; Ross, D. K.

2017-01-01

Studies of the inventory and distribution of water in lunar rocks have recently begun to focus on alkali suite samples as possible water repositories, particularly the most highly evolved granitoid lithologies. Although H analyses of feldspars in these rocks have so far pointed to 'low' (less than 20 ppm) H2O contents, there is sufficient variability in the dataset (e.g., 2-20 ppm) to warrant consideration of the petrogenetic factors that may have caused some granitoid-to-intermediate rocks to be dryer or wetter than others. Given that all examples of these rocks occur as clasts in complex impact breccias, the role of impact and other factors in altering water contents established by primary igneous processes becomes a major factor. We are supporting our ongoing SIMS studies of water in evolved lunar lithologies with systematic SEM and EPMA observations. Here we report a synthesis of the observations as part of developing discriminating factors for reconstructing the thermal, crystallization and shock history of these samples as compared with their water contents.

Systems Modelling of the Socio-Technical Aspects of Residential Electricity Use and Network Peak Demand.

PubMed

Lewis, Jim; Mengersen, Kerrie; Buys, Laurie; Vine, Desley; Bell, John; Morris, Peter; Ledwich, Gerard

2015-01-01

Provision of network infrastructure to meet rising network peak demand is increasing the cost of electricity. Addressing this demand is a major imperative for Australian electricity agencies. The network peak demand model reported in this paper provides a quantified decision support tool and a means of understanding the key influences and impacts on network peak demand. An investigation of the system factors impacting residential consumers' peak demand for electricity was undertaken in Queensland, Australia. Technical factors, such as the customers' location, housing construction and appliances, were combined with social factors, such as household demographics, culture, trust and knowledge, and Change Management Options (CMOs) such as tariffs, price, managed supply, etc., in a conceptual 'map' of the system. A Bayesian network was used to quantify the model and provide insights into the major influential factors and their interactions. The model was also used to examine the reduction in network peak demand with different market-based and government interventions in various customer locations of interest and investigate the relative importance of instituting programs that build trust and knowledge through well designed customer-industry engagement activities. The Bayesian network was implemented via a spreadsheet with a tickbox interface. The model combined available data from industry-specific and public sources with relevant expert opinion. The results revealed that the most effective intervention strategies involve combining particular CMOs with associated education and engagement activities. The model demonstrated the importance of designing interventions that take into account the interactions of the various elements of the socio-technical system. The options that provided the greatest impact on peak demand were Off-Peak Tariffs and Managed Supply and increases in the price of electricity. The impact in peak demand reduction differed for each of the locations and highlighted that household numbers, demographics as well as the different climates were significant factors. It presented possible network peak demand reductions which would delay any upgrade of networks, resulting in savings for Queensland utilities and ultimately for households. The use of this systems approach using Bayesian networks to assist the management of peak demand in different modelled locations in Queensland provided insights about the most important elements in the system and the intervention strategies that could be tailored to the targeted customer segments.

Systems Modelling of the Socio-Technical Aspects of Residential Electricity Use and Network Peak Demand

PubMed Central

Lewis, Jim; Mengersen, Kerrie; Buys, Laurie; Vine, Desley; Bell, John; Morris, Peter; Ledwich, Gerard

2015-01-01

Provision of network infrastructure to meet rising network peak demand is increasing the cost of electricity. Addressing this demand is a major imperative for Australian electricity agencies. The network peak demand model reported in this paper provides a quantified decision support tool and a means of understanding the key influences and impacts on network peak demand. An investigation of the system factors impacting residential consumers’ peak demand for electricity was undertaken in Queensland, Australia. Technical factors, such as the customers’ location, housing construction and appliances, were combined with social factors, such as household demographics, culture, trust and knowledge, and Change Management Options (CMOs) such as tariffs, price, managed supply, etc., in a conceptual ‘map’ of the system. A Bayesian network was used to quantify the model and provide insights into the major influential factors and their interactions. The model was also used to examine the reduction in network peak demand with different market-based and government interventions in various customer locations of interest and investigate the relative importance of instituting programs that build trust and knowledge through well designed customer-industry engagement activities. The Bayesian network was implemented via a spreadsheet with a tickbox interface. The model combined available data from industry-specific and public sources with relevant expert opinion. The results revealed that the most effective intervention strategies involve combining particular CMOs with associated education and engagement activities. The model demonstrated the importance of designing interventions that take into account the interactions of the various elements of the socio-technical system. The options that provided the greatest impact on peak demand were Off-Peak Tariffs and Managed Supply and increases in the price of electricity. The impact in peak demand reduction differed for each of the locations and highlighted that household numbers, demographics as well as the different climates were significant factors. It presented possible network peak demand reductions which would delay any upgrade of networks, resulting in savings for Queensland utilities and ultimately for households. The use of this systems approach using Bayesian networks to assist the management of peak demand in different modelled locations in Queensland provided insights about the most important elements in the system and the intervention strategies that could be tailored to the targeted customer segments. PMID:26226511

The impact of somatic symptoms on the course of major depressive disorder.

PubMed

Bekhuis, Ella; Boschloo, Lynn; Rosmalen, Judith G M; de Boer, Marrit K; Schoevers, Robert A

2016-11-15

Somatic symptoms have been suggested to negatively affect the course of major depressive disorder (MDD). Mechanisms behind this association, however, remain elusive. This study examines the impact of somatic symptoms on MDD prognosis and aims to determine whether this effect can be explained by psychiatric characteristics, somatic diseases, lifestyle factors, and disability. In 463 MDD patients (mean age=44.9 years, 69.8% female) from the Netherlands Study of Depression and Anxiety (NESDA), we examined whether the type and number of somatic symptom clusters predicted the two-year persistence of MDD. Diagnoses of MDD were established with the Composite International Diagnostic Interview (CIDI) and somatic symptom clusters were assessed with the Four-Dimensional Symptom Questionnaire (4DSQ) somatization scale. Psychiatric characteristics, somatic diseases, lifestyle factors, and disability were taken into account as factors potentially underlying the association. The cardiopulmonary, gastrointestinal, and general cluster significantly predicted the two-year persistence of MDD, but only when two or more of these clusters were present (OR=2.32, 95% CI=1.51-3.57, p=<0.001). Although the association was partly explained by MDD severity, the presence of multiple somatic symptom clusters remained a significant predictor after considering all potentially underlying factors (OR=1.69, 95%CI=1.07-2.68, p=0.03). Somatic symptoms are predictors of a worse prognosis of MDD independent of psychiatric characteristics, somatic diseases, lifestyle factors, and disability. These results stress the importance of considering somatic symptoms in the diagnostic and treatment trajectory of patients with MDD. Future research should focus on identifying treatment modalities targeting depressive as well as somatic symptoms. Copyright © 2016 Elsevier B.V. All rights reserved.

Cognitive and Motivational Factors that Inspire Hispanic Female Students to Pursue STEM-Related Academic Programs that Lead to Careers in Science, Technology, Engineering, and Mathematics

NASA Astrophysics Data System (ADS)

Morel-Baker, Sonaliz

Hispanics, and women in particular, continue to be underrepresented in the fields of science, technology, engineering, and mathematics (STEM). The purpose of this study was to analyze cognitive and motivational factors that inspired Hispanic female college students to major in STEM programs and aspire to academic success. This mixed methods study was conducted using both quantitative and qualitative data collection and analysis techniques in a sequential phase. Quantitative data were collected through the use of the 80-item Honey and Mumford Learning Styles Questionnaire, which was focused on the students' learning styles and how they impact Hispanic female students upon engaging in a STEM-related curriculum. Qualitative data were collected during interviews focusing on factors that led students to select, participate in, and make a commitment to some aspect of a STEM-related program. The questions that were asked during the interviews were intended to examine whether the existence of role models and STEM initiatives motivate Hispanic female students to major in STEM-related academic programs and aspire to academic success. The participants in this study were undergraduate Hispanic female students majoring in STEM-related academic programs and at a four-year university. The results indicate that the majority of the participants (88%) identified as reflectors, 4% as activists, 4% as theorists, and 4% as pragmatists. The results from the interviews suggested that the existence of role models (family members, educators, or STEM professionals) was a factor that motivated Hispanic females to major in STEM-related subjects and that exposure to STEM initiatives during K-12 education motivated Hispanic females to pursue a career in STEM.

Plant Abiotic Stress Proteomics: The Major Factors Determining Alterations in Cellular Proteome

PubMed Central

Kosová, Klára; Vítámvás, Pavel; Urban, Milan O.; Prášil, Ilja T.; Renaut, Jenny

2018-01-01

HIGHLIGHTS: Major environmental and genetic factors determining stress-related protein abundance are discussed.Major aspects of protein biological function including protein isoforms and PTMs, cellular localization and protein interactions are discussed.Functional diversity of protein isoforms and PTMs is discussed. Abiotic stresses reveal profound impacts on plant proteomes including alterations in protein relative abundance, cellular localization, post-transcriptional and post-translational modifications (PTMs), protein interactions with other protein partners, and, finally, protein biological functions. The main aim of the present review is to discuss the major factors determining stress-related protein accumulation and their final biological functions. A dynamics of stress response including stress acclimation to altered ambient conditions and recovery after the stress treatment is discussed. The results of proteomic studies aimed at a comparison of stress response in plant genotypes differing in stress adaptability reveal constitutively enhanced levels of several stress-related proteins (protective proteins, chaperones, ROS scavenging- and detoxification-related enzymes) in the tolerant genotypes with respect to the susceptible ones. Tolerant genotypes can efficiently adjust energy metabolism to enhanced needs during stress acclimation. Stress tolerance vs. stress susceptibility are relative terms which can reflect different stress-coping strategies depending on the given stress treatment. The role of differential protein isoforms and PTMs with respect to their biological functions in different physiological constraints (cellular compartments and interacting partners) is discussed. The importance of protein functional studies following high-throughput proteome analyses is presented in a broader context of plant biology. In summary, the manuscript tries to provide an overview of the major factors which have to be considered when interpreting data from proteomic studies on stress-treated plants. PMID:29472941

Mothers' experience of caring for a child with early onset scoliosis: A qualitative descriptive study.

PubMed

Lauder, Bonnie; Sinclair, Peter M; Maguire, Jane

2018-04-01

This study aimed to identify and describe the experience of parents of children diagnosed with early onset scoliosis living in Australia. Chronic childhood disease has a major impact on health-related quality of life. Caring for a child with a chronic illness is well documented but the specific experiences of parents who care for children with early onset scoliosis, a rare but devastating illness, has not been explored. Numerous studies have described the interrelated psychological, financial, social, physical and logistical factors that impact the experience of the caregiver role with various diseases, but in the case of early onset scoliosis, limited studies have been conducted about the parental experience. A qualitative descriptive design was used. A snowball sampling technique assisted in the recruitment. Parents invited to the study included mothers, fathers and guardians. Data were collected through semistructured interviews and transcribed verbatim. Transcripts were analysed thematically. Data collection complied with the Consolidated criteria for reporting qualitative research guidelines. Twelve mothers of children with early onset scoliosis were interviewed, as only mothers consented to participate. Four major themes emerged: emotional rollercoaster ride, a lack of resources, money talks and pervasive burden. Factors that impacted on the participants' ability to confront, manage and endure caring for a child with early onset scoliosis emerged from the data. The findings suggest there are multiple factors that influence the experience of mothers' caring for a child with early onset scoliosis. The recognition and appropriate management of these factors by healthcare professionals have the potential to improve the quality of life of parents who care for a child with early onset scoliosis. Healthcare professionals have first-line contact with parents of children with early onset scoliosis and are well placed to provide parents with evidence-based education and increased support. © 2018 John Wiley & Sons Ltd.

Publication times, impact factors, and advance online publication in ophthalmology journals.

PubMed

Chen, Haoyu; Chen, Chun Hui; Jhanji, Vishal

2013-08-01

Publication speed of peer-reviewed journals may play a major role in early dissemination of knowledge and may raise the citation index. In this study, we evaluated the publication speed of ophthalmology journals. Observational study. Observational study of bibliometric data in published ophthalmology journals. A list of ophthalmic journals featured in the 2010 Journal Citation Report was obtained on September 1, 2011. A total of 12 articles were chosen randomly from each of these journals published between January and December 2010. Median publication time and interquartile range (IQR) were obtained from the full texts of the published articles. Time lag between submission and revision, acceptance, and publication of the manuscripts was calculated. Correlation between publication time lag and journal impact factor as well as advance online publication was analyzed. A total of 51 ophthalmic journals were included. There was no statistically significant difference in the impact factors of journals based on their reporting of submission, revision, or acceptance times of the manuscripts (both P>0.05, Wilcoxon test). The median peer review and publication time of all ophthalmology journals was 133 days (IQR, 100.5-171.5) and 100 days (IQR, 62.9-166.3), respectively. There was no correlation between the journal impact factors and publication time lag (Spearman correlation). Approximately half of the ophthalmology journals (n = 26; 50.98%) published online in advance. Journals with advance online publication had higher impact factors compared with those without this feature (median, 1.692 [IQR, 1.05-2.80] vs. 1.02 [0.39-1.53]; P = 0.015, Mann-Whitney U test). For journals with advance online publication, the median time from acceptance to advance online publication (74.3 days [IQR, 48.3-115 days]) was significantly shorter than the median time between acceptance and print publication (170.75 days [IQR, 101.4-217 days]; P<0.001, Wilcoxon test). Publication time lag in ophthalmology journals was not correlated with journal impact factors. Advance online publication facility was provided by only half of the ophthalmology journals published in 2010. Journals with advance online publication had a higher impact factor compared with those without this feature. The author(s) have no proprietary or commercial interest in any materials discussed in this article. Copyright © 2013 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.

Can Soft Drink Taxes Reduce Population Weight?

PubMed Central

Fletcher, Jason M.; Frisvold, David

2009-01-01

Soft drink consumption has been hypothesized as one of the major factors in the growing rates of obesity in the US. Nearly two-thirds of all states currently tax soft drinks using excise taxes, sales taxes, or special exemptions to food exemptions from sales taxes to reduce consumption of this product, raise revenue, and improve public health. In this paper, we evaluate the impact of changes in state soft drink taxes on body mass index (BMI), obesity, and overweight. Our results suggest that soft drink taxes influence BMI, but that the impact is small in magnitude. PMID:20657817

Determination of the predictive factors of long-lasting insecticide-treated net ownership and utilisation in the Bamenda Health District of Cameroon.

PubMed

Fokam, Eric B; Kindzeka, Germaine F; Ngimuh, Leonard; Dzi, Kevin T J; Wanji, Samuel

2017-03-16

Malaria is a serious health concern in Africa. In Cameroon, an endemic country where malaria remains a major public health problem, several control measures have been put in place among which the use of insecticide-treated bednets (LLINs/ITNs) is considered one of the core vector control strategies. However, the greatest challenges include ownership and utilisation by individuals and households. Factors such as age, marital status, gender, education and occupation of the household head, household size, knowledge of bednets, socioeconomic status, and environmental factors have been suggested to have an impact on bednet ownership and utilisation in different settings. The present study sought to determine bednet ownership and utilisation rates and to assess the impact of predictive factors on bednet ownership and use in the Bamenda Health District (BHD) of Cameroon. A cross-sectional study involving 384 households was conducted in six health areas in the BHD. A structured and semi-structured questionnaire was used to collect data on demographic and household characteristics as well as information on their bednet ownership and utilisation. Descriptive statistics, bivariate and multivariate logistic regression analysis were performed. Frequency of bednet ownership was relatively high (63.5%) with LLINs being most abundant (91.9%); the majority of households (87.7%) obtained their bednets during the 2011 free distribution campaign. Utilisation was relatively high (69.3%), with negligence (29.3%) and heat discomfort (26.7%) accounting most for non-usage of bednets. Children less than 5 years (63%) and pregnant women (60%) most often used these nets. Households headed by a married couple, those with older household heads, household with smaller size (5-12 persons), and knowledge of bednets (good knowledge) had positive impacts on bednet ownership (p < 0.05). The gender of the household head (males), their educational level, environmental conditions (presence of suitable mosquito breeding sites), bednet number in households (greater number of bednets) and the prioritised groups (children < 5 and pregnant women) had positive impacts on bednet utilisation in households (p < 0.05). There was a negative association between bednet ownership and utilisation by households as bednet ownership was high and utilisation of these nets was low. Marital status and age of household head, household size, and knowledge of bednets had impacts on bednet ownership while gender and educational level of the household head, environmental suitability, the number of bednets and the two prioritised groups had an impact on bednet usage. These factors may be relevant for policy makers and in decision making for the intensification of campaign strategies to ensure more effective subsequent distribution campaigns in the BHD and beyond.

Environmental stressors influencing hormones and systems physiology in cattle

PubMed Central

2014-01-01

Environmental stressors undoubtedly influence organismal biology, specifically the endocrine system that, in turn, impact cattle at the systems physiology level. Despite the significant advances in understanding the genetic determinants of the ideal dairy or beef cow, there is a grave lack of understanding of the systems physiology and effects of the environmental stressors that interfere with the endocrine system. This is a major problem because the lack of such knowledge is preventing advances in understanding gene-environment interactions and developing science-based solutions to these challenges. In this review, we synthesize the current knowledge on the nature of the major environmental stressors, such as climate (heat, cold, wind, and humidity), nutrition (feeds, feeding systems, and endocrine disruptors) and management (housing density and conditions, transportation, weaning practices). We summarize the impact of each one of these factors on cattle at the systems level, and provide solutions for the challenges. PMID:24996419

Impact of terrorism on health and Hospital Anxiety Depression Scale screening in medical students, Karachi, Pakistan.

PubMed

Nasim, Sara; Khan, Mahjabeen; Aziz, Sina

2014-03-01

To determine the association of terrorism with psychiatric morbidity by Hospital Anxiety Depression scale among medical students in Karachi, Pakistan. The questionnaire based cross-sectional survey was conducted from February to March 2011 and comprised students of the Institute of Physical and Medical Rehabilitation and the Dow Medical College, Dow University of Health Sciences, Karachi. The study tool was a validated Hospital Anxiety Depression scale questionnaire. The data was analysed on SPSS 16. Factor analysis was performed to check which factors had the most influence. Overall there were 1036 respondents. The impact of terrorism on physical, social and mental health was 40 (3.9%), 178 (17.2%) and 818 (79%) respectively. There was an association of terrorism in 980 (84.6%) respondents with psychiatric morbidity. There was an association of terrorism with psychiatric morbidity in majority of respondents. The significant risk factors were age, gender, physical, mental and social health and the desire to live in Pakistan.

The Role of Neurotrophins in Major Depressive Disorder.

PubMed

Jiang, Cheng; Salton, Stephen R

2013-03-01

Neurotrophins and other growth factors have been advanced as critical modulators of depressive behavior. Support for this model is based on analyses of knockout and transgenic mouse models, human genetic studies, and screens for gene products that are regulated by depressive behavior and/or antidepressants. Even subtle alteration in the regulated secretion of brain-derived neurotrophic factor (BDNF), for example, due to a single nucleotide polymorphism (SNP)-encoded Val-Met substitution in proBDNF that affects processing and sorting, impacts behavior and cognition. Alterations in growth factor expression result in changes in neurogenesis as well as structural changes in neuronal cytoarchitecture, including effects on dendritic length and spine density, in the hippocampus, nucleus accumbens, and prefrontal cortex. These changes have the potential to impact the plasticity and stability of synapses in the CNS, and the complex brain circuitry that regulates behavior. Here we review the role that neurotrophins play in the modulation of depressive behavior, and the downstream signaling targets they regulate that potentially mediate these behavioral pro-depressant and antidepressant effects.

The Role of Neurotrophins in Major Depressive Disorder

PubMed Central

Jiang, Cheng; Salton, Stephen R.

2013-01-01

Neurotrophins and other growth factors have been advanced as critical modulators of depressive behavior. Support for this model is based on analyses of knockout and transgenic mouse models, human genetic studies, and screens for gene products that are regulated by depressive behavior and/or antidepressants. Even subtle alteration in the regulated secretion of brain-derived neurotrophic factor (BDNF), for example, due to a single nucleotide polymorphism (SNP)-encoded Val-Met substitution in proBDNF that affects processing and sorting, impacts behavior and cognition. Alterations in growth factor expression result in changes in neurogenesis as well as structural changes in neuronal cytoarchitecture, including effects on dendritic length and spine density, in the hippocampus, nucleus accumbens, and prefrontal cortex. These changes have the potential to impact the plasticity and stability of synapses in the CNS, and the complex brain circuitry that regulates behavior. Here we review the role that neurotrophins play in the modulation of depressive behavior, and the downstream signaling targets they regulate that potentially mediate these behavioral pro-depressant and antidepressant effects. PMID:23691270

The physiology of spacecraft and space suit atmosphere selection

NASA Astrophysics Data System (ADS)

Waligora, J. M.; Horrigan, D. J.; Nicogossian, A.

The majority of the environmental factors which comprise the spacecraft and space suit environments can be controlled at "Earth normal" values, at optimum values, or at other values decided upon by spacecraft designers. Factors which are considered in arriving at control values and control ranges of these parameters include physiological, engineering, operational cost, and safety considerations. Several of the physiologic considerations, including hypoxia and hyperoxia, hypercapnia, temperature regulation, and decompression sickness are identified and their impact on space craft and space suit atmosphere selection are considered. The past experience in controlling these parameters in U.S. and Soviet spacecraft and space suits and the associated physiological responses are reviewed. Current areas of physiological investigation relating to environmental factors in spacecraft are discussed, particularly decompression sickness which can occur as a result of change in pressure from Earth to spacecraft or spacecraft to space suit. Physiological considerations for long-term lunar or Martian missions will have different impacts on atmosphere selection and may result in the selection of atmospheres different than those currently in use.

The impact of dispensing fees on compliance with opioid substitution therapy: a mixed methods study

PubMed Central

2014-01-01

Background Opioid substitution therapy (OST) programs involve the dispensing of OST medicines to patients to address their dependence on heroin and/or other opioid substances. OST medicines are subsidised by the Australian government but patients need to pay the dispensing fees. This study explored opinions from OST patients and stakeholders about the potential impact of dispensing fees on compliance and OST program retention. Current and past experiences and the potential impact of OST dispensing fees were evaluated. Methods Mixed methodology was used to obtain data from OST patients and stakeholders. This involved 1) interviews with OST stakeholders, 2) a focus group of OST patients and 3) surveys of OST patients in Perth, Australia, between June and August 2013. Results The majority of the eight stakeholders declared cost as the factor mostly impacting on OST compliance. Almost all of the stakeholders commented that there was a positive correlation between time on the OST program and success in terms of relapse. Most stakeholders advocated for OST fees to contribute towards the Pharmaceutical Benefits Scheme Safety Net, and for fee subsidy. Focus group themes supported stakeholder interview findings. A total of 138 surveys were completed. Survey analysis illustrated a strong correlation between patient debt and impacted lifestyle: 82.4% (p < 0.001, Chi-square test) of the 138 survey participants stated that dispensing fees impacted significantly on patients’ finances and lifestyle, specifically those patients with major debt. The cost of dispensing fees was identified by 46.3% (64/138) of survey participants as the biggest impacting factor on patient success. Logistic regression models showed that the cost of dispensing fees was also found to significantly influence both the occurrence of debt (57.7%, p < 0.0001) and lifestyle difficulties (80.0%, p = 0.0004). Conclusion Findings provided insight into OST patients’ financial difficulties with data suggesting that dispensing fees are likely to have a negative impact on OST patients’ compliance with therapy, retention in the OST program and lifestyle. Government sponsorship of the OST dispensing fees should be considered as sponsorship would potentially increase the retention rates of income-poor OST program recipients. PMID:25108396

The impact of dispensing fees on compliance with opioid substitution therapy: a mixed methods study.

PubMed

Shepherd, Alexandra; Perrella, Bianca; Hattingh, Hendrika Laetitia

2014-08-10

Opioid substitution therapy (OST) programs involve the dispensing of OST medicines to patients to address their dependence on heroin and/or other opioid substances. OST medicines are subsidised by the Australian government but patients need to pay the dispensing fees. This study explored opinions from OST patients and stakeholders about the potential impact of dispensing fees on compliance and OST program retention. Current and past experiences and the potential impact of OST dispensing fees were evaluated. Mixed methodology was used to obtain data from OST patients and stakeholders. This involved 1) interviews with OST stakeholders, 2) a focus group of OST patients and 3) surveys of OST patients in Perth, Australia, between June and August 2013. The majority of the eight stakeholders declared cost as the factor mostly impacting on OST compliance. Almost all of the stakeholders commented that there was a positive correlation between time on the OST program and success in terms of relapse. Most stakeholders advocated for OST fees to contribute towards the Pharmaceutical Benefits Scheme Safety Net, and for fee subsidy. Focus group themes supported stakeholder interview findings. A total of 138 surveys were completed. Survey analysis illustrated a strong correlation between patient debt and impacted lifestyle: 82.4% (p < 0.001, Chi-square test) of the 138 survey participants stated that dispensing fees impacted significantly on patients' finances and lifestyle, specifically those patients with major debt. The cost of dispensing fees was identified by 46.3% (64/138) of survey participants as the biggest impacting factor on patient success. Logistic regression models showed that the cost of dispensing fees was also found to significantly influence both the occurrence of debt (57.7%, p < 0.0001) and lifestyle difficulties (80.0%, p = 0.0004). Findings provided insight into OST patients' financial difficulties with data suggesting that dispensing fees are likely to have a negative impact on OST patients' compliance with therapy, retention in the OST program and lifestyle. Government sponsorship of the OST dispensing fees should be considered as sponsorship would potentially increase the retention rates of income-poor OST program recipients.

Oil spills and their impacts on sand beach invertebrate communities: A literature review.

PubMed

Bejarano, Adriana C; Michel, Jacqueline

2016-11-01

Sand beaches are highly dynamic habitats that can experience considerable impacts from oil spills. This review provides a synthesis of the scientific literature on major oil spills and their impacts on sand beaches, with emphasis on studies documenting effects and recoveries of intertidal invertebrate communities. One of the key observations arising from this review is that more attention has generally been given to studying the impacts of oil spills on invertebrates (mostly macrobenthos), and not to documenting their biological recovery. Biological recovery of sand beach invertebrates is highly dynamic, depending on several factors including site-specific physical properties and processes (e.g., sand grain size, beach exposure), the degree of oiling, depth of oil burial, and biological factors (e.g., species-specific life-history traits). Recovery of affected communities ranges from several weeks to several years, with longer recoveries generally associated with physical factors that facilitate oil persistence, or when cleanup activities are absent on heavily oiled beaches. There are considerable challenges in quantifying impacts from spills on sand beach invertebrates because of insufficient baseline information (e.g., distribution, abundance and composition), knowledge gaps in their natural variability (spatial and temporal), and inadequate sampling and replication during and after oil spills. Thus, environment assessments of impacts and recovery require a rigorous experimental design that controls for confounding sources of variability. General recommendations on sampling strategies and toxicity testing, and a preliminary framework for incorporating species-specific life history traits into future assessments are also provided. Copyright © 2016 Elsevier Ltd. All rights reserved.

Patching the Leaky STEM Pipeline: Identifying Institutional Factors That Influence a STEM Qualified Female Undergraduate s Choice of Institution

NASA Astrophysics Data System (ADS)

Hurlock, Ashley J.

Despite increased female participation in the workforce and females earning more undergraduate degrees than men over the past decade, women are still awarded fewer undergraduate degrees than men and hold less than 25% of jobs in the areas of science, technology, engineering and math, or STEM (Beede, et al., 2011). Research shows that females may be leaking from the STEM pipeline because they are not choosing to attend institutions that fulfill their interdisciplinary and non-academic interests or have learning environments that are supportive of their needs. The purpose of this quantitative, cross-sectional survey study, conducted at one non-research intensive university, was to identify institutional factors most pertinent to the decision to attend a non-research intensive university by a "STEM qualified" female undergraduate student. 23 of 45 factors were reported as positively influencing their decision regardless of major. The top six factors for both groups were: average class size, campus environment, a visit to campus, university population size, and major/department offered. The seven factors ranked statistically significantly different between STEM and non-STEM majors were undergraduate research opportunities, faculty reputation, graduate/professional school admission, academic support/tutoring, graduate program available, intramural sports, and off-campus housing. Only two of 17 factors negatively influenced STEM majors who were accepted to a research intensive university: the research intensive university's size and average class sizes were undesirable compared to their current institution. STEM qualified females weighed the importance of non-academic factors as high, or higher, than critical academic factors. STEM qualified females are also choosing to attend the non-research intensive university for a variety of reasons and not simply because another institution did not offer certain academic factors. Future studies should expanded to include other non-research intensive universities, research intensive universities, and high schools in order to further understand the impact that certain factors have on female choice of institution. The authors strongly feel that if institutions which provide a more supportive environment for female undergraduates create successful recruitment initiatives, their female students may be more likely to persist as STEM majors. This could potentially patch one of the substantial leaks in the STEM pipeline for women.

Prevention and Treatment of Traumatic Brain Injury Due to Rapid-Onset Natural Disasters

PubMed Central

Regens, James L.; Mould, Nick

2014-01-01

The prevention and treatment of traumatic brain injury (TBI) attributable to rapid-onset natural disasters is a major challenge confronting disaster preparedness planners and emergency medical personnel responding to those incidents. The kinetic energy released by rapid-onset natural disasters such as earthquakes, hurricanes or typhoons, and tornadoes can cause mild, moderate, or severe TBIs. As a result, neurotrauma is a major risk factor for mortality and morbidity outcomes within the spatial domain impacted by a rapid-onset natural disaster. This review article elucidates major challenges associated with immediate emergency medical response, long-term care, and prevention of post-event increases in pediatric TBIs because of child abuse when rapid-onset natural disasters occur. PMID:24783188

Explaining the decline in coronary heart disease mortality in the Czech Republic between 1985 and 2007.

PubMed

Bruthans, Jan; Cífková, Renata; Lánská, Věra; O'Flaherty, Martin; Critchley, Julia A; Holub, Jiří; Janský, Petr; Zvárová, Jana; Capewell, Simon

2014-07-01

Coronary heart disease (CHD) mortality has declined substantially in the Czech Republic over the last two decades. The purpose of this study was to determine what proportion of this CHD mortality decline could be associated with temporal trends in major CHD risk factors and what proportion with advances in medical and surgical treatments. The validated IMPACT mortality model was used to combine and analyse data on uptake and effectiveness of CHD management and risk factor trends in the Czech Republic in adults aged 25-74 years between 1985 and 2007. The main sources were official statistics, national quality of care registries, published trials and meta-analyses, and the Czech MONICA and Czech post-MONICA studies. Between 1985 and 2007, age-adjusted CHD mortality rates in the Czech Republic decreased by 66.2% in men and 65.4% in women in the age group 25-74 years, representing 12,080 fewer CHD deaths in 2007. Changes in CHD risk factors explained approximately 52% of the total mortality decrease, and improvements in medical treatments approximately 43%. Increases in body mass index and in diabetes prevalence had a negative impact, increasing CHD mortality by approximately 1% and 5%, respectively. More than half of the very substantial fall in CHD mortality in the Czech Republic between 1985 and 2007 was attributable to reduction in major cardiovascular risk factors. Improvement in treatments accounted for approximately 43% of the total mortality decrease. These findings emphasize the value of primary prevention and evidence-based medical treatment. © The European Society of Cardiology 2012.

The Impact of Celebrity Suicide on Subsequent Suicide Rates in the General Population of Korea from 1990 to 2010.

PubMed

Park, Juhyun; Choi, Nari; Kim, Seog Ju; Kim, Soohyun; An, Hyonggin; Lee, Heon-Jeong; Lee, Yu Jin

2016-04-01

The association between celebrity suicide and subsequent increase in suicide rates among the general population has been suggested. Previous studies primarily focused on celebrity suicides in the 2000s. To better understand the association, this study examined the impacts of celebrity suicides on subsequent suicide rates using the data of Korean celebrity suicides between 1990 and 2010. Nine celebrity suicides were selected by an investigation of media reports of suicide deaths published in three major newspapers in Korea between 1990 and 2010. Suicide mortality data were obtained from the National Statistical Office of Korea. Seasonal autoregressive integrated moving average models with intervention analysis were used to test the impacts of celebrity suicides, controlling for seasonality. Six of the 9 celebrity suicides had significant impacts on suicide rates both in the total population and in the same gender- or the same age-subgroups. The incident that occurred in the 1990s had no significant impact on the overall suicide rates, whereas the majority of the incidents in the 2000s had significant influences for 30 or 60 days following each incident. The influence of celebrity suicide was shown to reach its peak following the suicide death of a renowned actress in 2008. The findings may suggest a link between media coverage and the impact of celebrity suicide. Future studies should focus more on the underlying processes and confounding factors that may contribute to the impact of celebrity suicide on subsequent suicide rates.

The Impact of Celebrity Suicide on Subsequent Suicide Rates in the General Population of Korea from 1990 to 2010

PubMed Central

2016-01-01

The association between celebrity suicide and subsequent increase in suicide rates among the general population has been suggested. Previous studies primarily focused on celebrity suicides in the 2000s. To better understand the association, this study examined the impacts of celebrity suicides on subsequent suicide rates using the data of Korean celebrity suicides between 1990 and 2010. Nine celebrity suicides were selected by an investigation of media reports of suicide deaths published in three major newspapers in Korea between 1990 and 2010. Suicide mortality data were obtained from the National Statistical Office of Korea. Seasonal autoregressive integrated moving average models with intervention analysis were used to test the impacts of celebrity suicides, controlling for seasonality. Six of the 9 celebrity suicides had significant impacts on suicide rates both in the total population and in the same gender- or the same age-subgroups. The incident that occurred in the 1990s had no significant impact on the overall suicide rates, whereas the majority of the incidents in the 2000s had significant influences for 30 or 60 days following each incident. The influence of celebrity suicide was shown to reach its peak following the suicide death of a renowned actress in 2008. The findings may suggest a link between media coverage and the impact of celebrity suicide. Future studies should focus more on the underlying processes and confounding factors that may contribute to the impact of celebrity suicide on subsequent suicide rates. PMID:27051245

Trends in socioeconomic inequalities in five major risk factors for cardiovascular disease in the Korean population: a cross-sectional study using data from the Korea National Health and Nutrition Examination Survey, 2001-2014.

PubMed

Kim, Yoon Jung; Lee, Ji Sung; Park, Juri; Choi, Dong Seop; Kim, Doo Man; Lee, Kee-Hyoung; Kim, Ho Yeon; Kim, Sin Gon; Lee, Juneyoung

2017-05-17

To examine trends in socioeconomic inequalities in major cardiovascular disease (CVD) risk factors among the Korean population. Cross-sectional study. A nationally representative population survey database. A total of 42 725 Koreans, aged 25-64 years, who participated in the Korean National Health and Nutrition Examination Survey (KNHANES) II (2001) to VI (2013-2014). Trends in socioeconomic inequalities in five major CVD risk factors (smoking, obesity, diabetes, hypertension and hypercholesterolaemia). Gender differences were noted in the time trends in socioeconomic inequalities in smoking, obesity, diabetes and hypertension. Among men, low socioeconomic status (SES) was associated with higher prevalence of smoking, but not with obesity, diabetes or hypertension. The magnitudes of socioeconomic inequalities in smoking, obesity and diabetes remained unchanged, and the magnitude of the inequality in hypertension decreased over time. However, among women, low SES was associated with higher prevalence of smoking, obesity, diabetes and hypertension. Time trends towards increasing socioeconomic inequalities, measured by income, in smoking, obesity and diabetes were found in women. Unlike the other CVD risk factors, hypercholesterolaemia was not associated with socioeconomic inequality. SES had a stronger impact on major CVD risk factors among Korean women than men. Moreover, socioeconomic inequalities in smoking, obesity and diabetes worsened among Korean women over time. Public policies to prevent smoking, obesity and diabetes in women with lower SES are needed to address inequalities. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Recessions and Health: The Impact of Economic Trends on Air Pollution in California

PubMed Central

2012-01-01

Objectives. I explored the hypothesis that economic activity has a significant impact on exposure to air pollution and ultimately human health. Methods. I used county-level employment statistics in California (1980–2000), along with major regulatory periods and other controlling factors, to estimate local concentrations of the coefficient of haze, carbon monoxide, and nitrogen dioxide using a mixed regression model approach. Results. The model explained between 33% and 48% of the variability in air pollution levels as estimated by the overall R2 values. The relationship between employment measures and air pollution was statistically significant, suggesting that air quality improves during economic downturns. Additionally, major air quality regulations played a significant role in reducing air pollution levels over the study period. Conclusions. This study provides important evidence of a role for the economy in understanding human exposure to environmental pollution. The evidence further suggests that the impact of environmental regulations are likely to be overstated when they occur during recessionary periods, and understated when they play out during periods of economic growth. PMID:22897522

Multiple imputation for estimating the risk of developing dementia and its impact on survival.

PubMed

Yu, Binbing; Saczynski, Jane S; Launer, Lenore

2010-10-01

Dementia, Alzheimer's disease in particular, is one of the major causes of disability and decreased quality of life among the elderly and a leading obstacle to successful aging. Given the profound impact on public health, much research has focused on the age-specific risk of developing dementia and the impact on survival. Early work has discussed various methods of estimating age-specific incidence of dementia, among which the illness-death model is popular for modeling disease progression. In this article we use multiple imputation to fit multi-state models for survival data with interval censoring and left truncation. This approach allows semi-Markov models in which survival after dementia depends on onset age. Such models can be used to estimate the cumulative risk of developing dementia in the presence of the competing risk of dementia-free death. Simulations are carried out to examine the performance of the proposed method. Data from the Honolulu Asia Aging Study are analyzed to estimate the age-specific and cumulative risks of dementia and to examine the effect of major risk factors on dementia onset and death.

Influence of Beijing outflow on Volatile Organic Compounds (VOC) observed at a mountain site in North China Plain

NASA Astrophysics Data System (ADS)

Suthawaree, Jeeranut; Kato, Shungo; Pochanart, Pakpong; Kanaya, Yugo; Akimoto, Hajime; Wang, Zifa; Kajii, Yoshizumi

2012-07-01

In order to elucidate an impact of Beijing outflow on air quality in the mountainous area, measurement campaign was carried out in Mt. Mang, located 40 km north of Beijing in September 2007. Volatile Organic Compounds (VOC) observed at the site were mainly influenced by air masses arriving from urban areas. No significant impact of local emission was found. Correlation plots between selected VOC suggests several major emission sources as internal combustion, industrial emission, and coal, oil and biofuel burning. Air masses were classified into “polluted” (influence of Beijing and its satellite cities) and “clean” air mass by using backward trajectory analysis. Two air mass categories revealed significant different characteristics and mixing ratios. Reaction with OH is a major factor controlling mixing ratio of “clean” air mass while impact of dilution is also play important role on “polluted” air mass. Estimation of photochemical age of “polluted” air mass by assuming “clean” air mass for background mixing ratios reveals an averaged of 1.5-1.8 days.

Systematic review: Outcome reporting bias is a problem in high impact factor neurology journals

PubMed Central

Scott, Jared T.; Blubaugh, Mark; Roepke, Brie; Scheckel, Caleb; Vassar, Matt

2017-01-01

Background Selective outcome reporting is a significant methodological concern. Comparisons between the outcomes reported in clinical trial registrations and those later published allow investigators to understand the extent of selection bias among trialists. We examined the possibility of selective outcome reporting in randomized controlled trials (RCTs) published in neurology journals. Methods We searched PubMed for randomized controlled trials from Jan 1, 2010 –Dec 31, 2015 published in the top 3 impact factor neurology journals. These articles were screened according to specific inclusion criteria. Each author individually extracted data from trials following a standardized protocol. A second author verified each extracted element and discrepancies were resolved. Consistency between registered and published outcomes was evaluated and correlations between discrepancies and funding, journal, and temporal trends were examined. Results 180 trials were included for analysis. 10 (6%) primary outcomes were demoted, 38 (21%) primary outcomes were omitted from the publication, and 61 (34%) unregistered primary outcomes were added to the published report. There were 18 (10%) cases of secondary outcomes being upgraded to primary outcomes in the publication, and there were 53 (29%) changes in timing of assessment. Of 82 (46%) major discrepancies with reported p-values, 54 (66.0%) favored publication of statistically significant results. Conclusion Across trials, we found 180 major discrepancies. 66% of major discrepancies with a reported p-value (n = 82) favored statistically significant results. These results suggest a need within neurology to provide more consistent and timely registration of outcomes. PMID:28727834

Systematic review: Outcome reporting bias is a problem in high impact factor neurology journals.

PubMed

Howard, Benjamin; Scott, Jared T; Blubaugh, Mark; Roepke, Brie; Scheckel, Caleb; Vassar, Matt

2017-01-01

Selective outcome reporting is a significant methodological concern. Comparisons between the outcomes reported in clinical trial registrations and those later published allow investigators to understand the extent of selection bias among trialists. We examined the possibility of selective outcome reporting in randomized controlled trials (RCTs) published in neurology journals. We searched PubMed for randomized controlled trials from Jan 1, 2010 -Dec 31, 2015 published in the top 3 impact factor neurology journals. These articles were screened according to specific inclusion criteria. Each author individually extracted data from trials following a standardized protocol. A second author verified each extracted element and discrepancies were resolved. Consistency between registered and published outcomes was evaluated and correlations between discrepancies and funding, journal, and temporal trends were examined. 180 trials were included for analysis. 10 (6%) primary outcomes were demoted, 38 (21%) primary outcomes were omitted from the publication, and 61 (34%) unregistered primary outcomes were added to the published report. There were 18 (10%) cases of secondary outcomes being upgraded to primary outcomes in the publication, and there were 53 (29%) changes in timing of assessment. Of 82 (46%) major discrepancies with reported p-values, 54 (66.0%) favored publication of statistically significant results. Across trials, we found 180 major discrepancies. 66% of major discrepancies with a reported p-value (n = 82) favored statistically significant results. These results suggest a need within neurology to provide more consistent and timely registration of outcomes.

An Analysis of the Performance of Public Elementary Schools in New York City during 2001-2005 from a Geographical Perspective

ERIC Educational Resources Information Center

Kellici, Ylli

2009-01-01

This study examines from a geographical perspective the factors that impact the performance of public elementary schools in New York City during 2001-2005, a period when its schools were undergoing major reforms at both the local and national level. Education reforms have focused their attention on schools by increasing their responsibility and…

An Assessment of the Impact of Time Management Training on Student Success in a Time-Intensive Course

ERIC Educational Resources Information Center

Goodwin, M. M.; Califf, M. E.

2007-01-01

Workload has been found to be a major course-related factor that affects student dropout rates. A heavy workload combined with a lack of time can create problems for students with courses that, by their very nature, require extensive work outside of class time. One such course is the second-semester programming course at Illinois State University…

Using Learner Controlled Progress-Based Rewards to Promote Motivation and Achievement of At-Risk Students in Managed Online Learning Environments

ERIC Educational Resources Information Center

Cunningham, Carlton A.

2011-01-01

Technology enhancements of the past two decades have not successfully overcome the problem of low motivation in Kindergarten through Grade 12 (K-12). Motivation and math achievement have been identified as major factors contributing to the high school dropout problem (30-50% in traditional/online programs). The impact of extrinsic rewards on…

Evolution of the Early Childhood Curriculum in China: The Impact of Social and Cultural Factors on Revolution and Innovation

ERIC Educational Resources Information Center

Li, Hui; Chen, Jennifer J.

2017-01-01

During the last century, early childhood curriculum (ECC) in China has undergone a series of monumental transformations, shaped by the interaction between local cultural and global forces. In this case study, we critically analyse three major waves of ECC reform in China, with a particular emphasis on the social and cultural forces that have…

A Descriptive Study of the Tuition Reimbursement Policies of Ten Major Corporations in Cuyahoga County, Ohio.

ERIC Educational Resources Information Center

Lidstrom, Kermit

This study was conducted to learn about the impact and extent of Corporate Tuition Reimbursement (CTR) in Cuyahoga County, Ohio. Tuition is a factor in Ohio because tuition is charged in the community colleges. Literature on the trends in income sources in higher education and the shift to older part-time students are reviewed. Ten CTR policies of…

The Impact of Language on Educational Access in South Africa. CREATE Pathways to Access. Research Monograph No. 24

ERIC Educational Resources Information Center

Lafon, Michel

2009-01-01

The role of Medium of Instruction or Language of Learning and Teaching has not received sufficient attention as a factor denying meaningful access to education in South Africa. Yet the majority of under-performing learners are also children who learn in a language that is not their mother-tongue. This research aims to assess how recent language…

Calf health from birth to weaning. I. General aspects of disease prevention

PubMed Central

2011-01-01

Calfhood diseases have a major impact on the economic viability of cattle operations. This is the first in a three part review series on calf health from birth to weaning, focusing on preventive measures. The review considers both pre- and periparturient management factors influencing calf health, colostrum management in beef and dairy calves and further nutrition and weaning in dairy calves. PMID:21923898

Personalities and Pipelines: Exploring the Role of Personality in Student Self-Selection into STEM Majors

ERIC Educational Resources Information Center

Simpson, Patricia

2012-01-01

Despite all the national efforts to increase STEM enrollment in the United States, the gap between the U.S. and other developed countries in terms of STEM graduates has widened over the last 20 years. Researchers have studied factors such as gender, race, high school GPA, and the student's socioeconomic status for their impact on STEM enrollment.…

Northrop Triga facility decommissioning plan versus actual results

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gardner, F.W.

1986-01-01

This paper compares the Triga facility decontamination and decommissioning plan to the actual results and discusses key areas where operational activities were impacted upon by the final US Nuclear Regulatory Commission (NRC)-approved decontamination and decommissioning plan. Total exposures for fuel transfer were a factor of 4 less than planned. The design of the Triga reactor components allowed the majority of the components to be unconditionally released.

Regional Famine Patterns of The Last Millennium as Influenced by Aggregated Climate Teleconnections

NASA Astrophysics Data System (ADS)

Santoro, Michael Melton

Famine is the result of a complex set of environmental and social factors. Climate conditions are established as environmental factors contributing to famine occurrence, often through teleconnective patterns. This dissertation is designed to investigate the combined influence on world famine patterns of teleconnections, specifically the North Atlantic Oscillation (NAO), Southern Oscillation (SO), Pacific Decadal Oscillation (PDO), Atlantic Multidecadal Oscillation (AMO), or regional climate variations such as the South Asian Summer Monsoon (SASM). The investigation is three regional case studies of famine patterns specifically, Egypt, the British Isles, and India. The first study (published in Holocene) employs the results of a Principal Component Analysis (PCA) yielding a SO-NAO eigenvector to predict major Egyptian famines between AD 1049-1921. The SO-NAO eigenvector (1) successfully discriminates between the 5-10 years preceding a famine and the other years, (2) predicts eight of ten major famines, and (3) correctly identifies fifty out of eighty events (63%) of food availability decline leading up to major famines. The second study investigates the impact of the NAO, PDO, SO, and AMO on 63 British Isle famines between AD 1049 and 1914 attributed to climate causes in historical texts. Stepwise Regression Analysis demonstrates that the 5-year lagged NAO is the primary teleconnective influence on famine patterns; it successfully discriminates 73.8% of weather-related famines in the British Isles from 1049 to 1914. The final study identifies the aggregated influence of the NAO, SO, PDO, and SASM on 70 Indian famines from AD 1049 to 1955. PCA results in a NAO-SOI vector and SASM vector that predicts famine conditions with a positive NAO and negative SO, distinct from the secondary SASM influence. The NAO-famine relationship is consistently the strongest; 181 of 220 (82%) of all famines occurred during positive NAO years. Ultimately, the causes of famine are complex and involve many factors including societal and climatic. This dissertation demonstrates that climate teleconnections impact famine patterns and often the aggregates of multiple climate variables hold the most significant climatic impact. These results will increase the understanding of famine patterns and will help to better allocate resources to alleviate future famines.

Milestones and impact factors.

PubMed

Ozonoff, David M; Grandjean, Philippe

2010-07-08

Environmental Health has just received its first Impact Factor by Thomson ISI. At a level of 2.48, this achievement is quite satisfactory and places Environmental Health in the top 25% of environmental science journals. When the journal was launched in 2002, it was still unclear whether the Open Access publishing model could be made into a viable commercial enterprise within the biomedical field. During the past eight years, Open Access journals have become widely available, although still covering only about 15% of journal titles. Major funding agencies and institutions, including prominent US universities, now require that researchers publish in Open Access journals. Because of the profound role of scientific journals for the sharing of results and communication between researchers, the advent of Open Access may be of as much significance as the transition from handwriting to printing via moveable type. As Environmental Health is an electronic Open Access journal, the numbers of downloads at the journal website can be retrieved. The top-20 list of articles most frequently accessed shows that all of them have been downloaded over 10,000 times. Back in 2002, the first article published was accessed only 49 times during the following month. A year later, the server had over 1,000 downloads per month, and now the total number of monthly downloads approaches 50,000. These statistics complement the Impact Factor and confirm the viability of Open Access in our field of research. The advent of digital media and its decentralized mode of distribution - the internet - have dramatically changed the control and financing of scientific information dissemination, while facilitating peer review, accelerating editorial handling, and supporting much needed transparency. Both the meaning and means of "having an impact" are therefore changing, as will the degree and way in which scientific journals remain "factors" in that impact.

Milestones and Impact Factors

PubMed Central

2010-01-01

Environmental Health has just received its first Impact Factor by Thomson ISI. At a level of 2.48, this achievement is quite satisfactory and places Environmental Health in the top 25% of environmental science journals. When the journal was launched in 2002, it was still unclear whether the Open Access publishing model could be made into a viable commercial enterprise within the biomedical field. During the past eight years, Open Access journals have become widely available, although still covering only about 15% of journal titles. Major funding agencies and institutions, including prominent US universities, now require that researchers publish in Open Access journals. Because of the profound role of scientific journals for the sharing of results and communication between researchers, the advent of Open Access may be of as much significance as the transition from handwriting to printing via moveable type. As Environmental Health is an electronic Open Access journal, the numbers of downloads at the journal website can be retrieved. The top-20 list of articles most frequently accessed shows that all of them have been downloaded over 10,000 times. Back in 2002, the first article published was accessed only 49 times during the following month. A year later, the server had over 1,000 downloads per month, and now the total number of monthly downloads approaches 50,000. These statistics complement the Impact Factor and confirm the viability of Open Access in our field of research. The advent of digital media and its decentralized mode of distribution - the internet - have dramatically changed the control and financing of scientific information dissemination, while facilitating peer review, accelerating editorial handling, and supporting much needed transparency. Both the meaning and means of "having an impact" are therefore changing, as will the degree and way in which scientific journals remain "factors" in that impact. PMID:20615249

The requirements for batteries for electric vehicles

NASA Technical Reports Server (NTRS)

Schwartz, H. J.

1976-01-01

The paper reassesses the role of electric vehicles in the modern transportation system and their potential impact on oil consumption. Three major factors determining the size of this impact are discussed: the market potential, the date of introduction, and the rate of consumer acceptance. The strategy of selecting the battery type for an urban car to introduce in coming years is analyzed. The results of the analysis suggest that the research and development emphasis should be placed on near- and mid-term battery technology. From the standpoint of maximizing both the cumulative impact and the benefits derived in the year 2000, however, a strategy of early introduction of near-term and mid-term cars followed by the far-term vehicles seems to produce the optimum result.

Quantitative attribution of major driving forces on soil organic carbon dynamics

USGS Publications Warehouse

Wu, Yiping; Liu, Shuguang; Tan, Zhengxi

2015-01-01

Soil organic carbon (SOC) storage plays a major role in the global carbon cycle and is affected by many factors including land use/management changes (e.g., biofuel production-oriented changes). However, the contributions of various factors to SOC changes are not well understood and quantified. This study was designed to investigate the impacts of changing farming practices, initial SOC levels, and biological enhancement of grain production on SOC dynamics and to attribute the relative contributions of major driving forces (CO2 enrichment and farming practices) using a fractional factorial modeling design. The case study at a crop site in Iowa in the United States demonstrated that the traditional corn-soybean (CS) rotation could still accumulate SOC over this century (from 4.2 to 6.8 kg C/m2) under the current condition; whereas the continuous-corn (CC) system might have a higher SOC sequestration potential than CS. In either case, however, residue removal could reduce the sink potential substantially. Long-term simulation results also suggested that the equilibrium SOC level may vary greatly (∼5.7 to ∼11 kg C/m2) depending on cropping systems and management practices, and projected growth enhancement could make the magnitudes higher (∼7.8 to ∼13 kg C/m2). Importantly, the factorial design analysis indicated that residue management had the most significant impact (contributing 49.4%) on SOC changes, followed by CO2 Enrichment (37%), Tillage (6.2%), the combination of CO2Enrichment-Residue removal (5.8%), and Fertilization (1.6%). In brief, this study is valuable for understanding the major forces driving SOC dynamics of agroecosystems and informative for decision-makers when seeking the enhancement of SOC sequestration potential and sustainability of biofuel production, especially in the Corn Belt region of the United States.

The impact of major depression on heart rate variability and endothelial dysfunction in patients with stable coronary artery disease.

PubMed

Aydin Sunbul, Esra; Sunbul, Murat; Gulec, Huseyin

Depression is an independent risk factor in cardiovascular diseases. Changes in the cardiac autonomic functions and pro-inflammatory processes are potential biological factors. Endothelial dysfunction plays an important role in the etiopathogenesis of atherosclerosis. Our objective was to evaluate the impact of major depression on heart rate variability and endothelial dysfunction in patients with stable CAD. The study group included 65 CAD patients with a diagnosis of major depression and 54 CAD patients without major depression. All study population underwent transthoracic echocardiography, measurement of flow mediated dilatation (FMD) and 24-h holter recording for heart rate variability (HRV). Blood samples were drawn to determine the inflammatory parameters. Severity of depressive episode was assessed by Montgomery-Asberg Depression Scale (MADRS). The distribution of age and sex was similar in the patient and control groups (P=0.715, 0.354, respectively). There was no significant difference in medications used between the groups. Echocardiographic parameters were similar between the groups. Inflammatory parameters were also similar between the groups. HRV parameters were significantly lower in the patient group than controls. The absolute FMD value and percentage FMD were significantly lower in the patient group than controls (P<0.001). The MADRS score correlated with pNN50 in both groups (P<0.05), and with FMD in the control group (P<0.001), even after adjusting for age and gender (P<0.001). MADRS score was an independent predictor of pNN50 level, percentage and absolute FMD values regardless of age and gender. Clinician should pay more attention for evaluation of depressive patients with CAD. Copyright © 2016 Elsevier Inc. All rights reserved.

Bio-Medical Factors and External Hazards in Space Station Design

NASA Technical Reports Server (NTRS)

Olling, Edward H.

1966-01-01

The design of space-station configurations is influenced by many factors, Probably the most demanding and critical are the biomedical and external hazards requirements imposed to provide the proper environment and supporting facilities for the crew and the adequate protective measures necessary to provide a configuration in which the crew can live and work efficiently in relative comfort and safety. The major biomedical factors, such as physiology, psychology, nutrition, personal hygiene, waste management, and recreation, all impose their own peculiar requirements. The commonality and integration of these requirements demand the utmost ingenuity and inventiveness be exercised in order to achieve effective configuration compliance. The relationship of biomedical factors for the internal space-station environment will be explored with respect to internal atmospheric constituency, atmospheric pressure levels, oxygen positive pressure, temperature, humidity, CO2 concentration, and atmospheric contamination. The range of these various parameters and the recommended levels for design use will be analyzed. Requirements and criteria for specific problem areas such as zero and artificial gravity and crew private quarters will be reviewed and the impact on the design of representative solutions will be presented. In the areas of external hazards, the impact of factors such as meteoroids, radiation, vacuum, temperature extremes, and cycling on station design will be evaluated. Considerations with respect to operational effectiveness and crew safety will be discussed. The impact of such factors on spacecraft design to achieve acceptable launch and reentry g levels, crew rotation intervals, etc., will be reviewed. Examples of configurations, subsystems, and internal a arrangement and installations to comply with such biomedical factor requirements will ber presented. The effects of solutions to certain biomedical factors on configuration weight, operational convenience, and program costs will be compared.

Human Health Impacts of and Public Health Adaptation to Climate Variability and Change

NASA Astrophysics Data System (ADS)

Ebi, K. L.

2007-12-01

Weather and climate are among the factors that determine the geographic range and incidence of several major causes of ill health, including undernutrition, diarrheal diseases and other conditions due to unsafe water and lack of basic sanitation, and malaria. The Human Health chapter in the Fourth Assessment Report of the Intergovernmental Panel on Climate Change concluded that climate change has begun to negatively affect human health, and that projected climate change will increase the risks of climate-sensitive health outcomes, particularly in lower-income populations, predominantly within tropical/subtropical countries. Those at greatest risk include the urban poor, older adults, children, traditional societies, subsistence farmers, and coastal populations, particularly in low income countries. The cause-and-effect chain from climate change to changing patterns of health determinants and outcomes is complex and includes socioeconomic, institutional, and other factors. The severity of future impacts will be determined by changes in climate as well as by concurrent changes in nonclimatic factors and by the adaptation measures implemented to reduce negative impacts. Public health has a long history of effectively intervening to reduce risks to the health of individuals and communities. Lessons learned from more than 150 years of research and intervention can provide insights to guide the design and implementation of effective and efficient interventions to reduce the current and projected impacts of climate variability and change.

Attribution of risk for coronary heart disease in a vulnerable immigrant population: a survey study.

PubMed

Fernandez, Ritin; Davidson, Patricia M; Miranda, Charmaine; Everett, Bronwyn; Salamonson, Yenna

2014-01-01

Coronary heart disease (CHD) is a common and costly condition and is increasing at a higher rate among Asian Indians than among other ethnic groups. An understanding of how Asian Indians perceive their risk is important for health providers to develop culturally appropriate programs to raise awareness of the risk of CHD. The aim of this survey was to investigate the attribution of risk factors for CHD among the Asian Indian community in Australia. Asian Indian community leaders were recruited to provide their views of how their community perceived the risk of CHD. An online survey collected demographic data and information from the Illness Perception Questionnaire-Revised, which measures 6 domains of illness perception: timeline acute/chronic, consequences, emotional impact, personal control, treatment efficacy, and illness comprehension. An 84% response rate (n = 49) was achieved from Asian Indian community leaders. Heart disease and cancer were considered to be the illnesses of major concern. Participants indicated that people in their community perceived hereditary factors (90%), hypertension, stress or worry (84%), and aging (86%) as the major cause of their illnesses. Smoking, high blood pressure, and cholesterol were identified as being major risk factors for CHD. These data suggest that as well as strategies to address risk factors such as diet and exercise, stress management is an important issue to consider in developing community-based programs.

An Exploratory Study on the Impact of Domestic Violence on the Families in Trinidad and Tobago, the West Indies.

PubMed

Johnson, Emmanuel Janagan

2017-01-01

The purpose of this study is to explore the impact of domestic violence on the economic condition of the families. This cross-sectional study utilized a non-probability sampling procedure (purposive sampling) that included 30 women who have sought services from the Coalition Against Domestic Violence Agency. Data were collected using a questionnaire, which was comprised of 21 questions. The questions sought information on socioeconomic conditions and impact on domestic violence on the financial position. The study revealed that more of domestic violence victims were at an early age. Recommendations for future research include identifying the major causes for family disorganization and break down in the families arise out of domestic violence and other associated factors where explored while emphasizing the importance of family-based programs that minimize the impact.

The human microbiota associated with overall health.

PubMed

Xu, Xiaofei; Wang, Zhujun; Zhang, Xuewu

2015-03-01

Human body harbors diverse microbes, the main components include bacteria, eukaryotes and viruses. Emerging evidences show that the human microbiota is intrinsically linked with overall health. The development of next-generation sequencing provides an unprecedented opportunity to investigate the complex microbial communities that are associated with the human body. Many factors like host genetics and environmental factors have a major impact on the composition and dynamic changes of human microbiota. The purpose of this paper is to present an overview of the relationship between human health and human microbiota (skin, nasal, throat, oral, vaginal and gut microbiota), then to focus on the factors modulating the composition of the microbiota and the future challenges to manipulate the microbiota for personalized health.

Potential of best practice to reduce impacts from oil and gas projects in the Amazon.

PubMed

Finer, Matt; Jenkins, Clinton N; Powers, Bill

2013-01-01

The western Amazon continues to be an active and controversial zone of hydrocarbon exploration and production. We argue for the urgent need to implement best practices to reduce the negative environmental and social impacts associated with the sector. Here, we present a three-part study aimed at resolving the major obstacles impeding the advancement of best practice in the region. Our focus is on Loreto, Peru, one of the largest and most dynamic hydrocarbon zones in the Amazon. First, we develop a set of specific best practice guidelines to address the lack of clarity surrounding the issue. These guidelines incorporate both engineering-based criteria and key ecological and social factors. Second, we provide a detailed analysis of existing and planned hydrocarbon activities and infrastructure, overcoming the lack of information that typically hampers large-scale impact analysis. Third, we evaluate the planned activities and infrastructure with respect to the best practice guidelines. We show that Loreto is an extremely active hydrocarbon front, highlighted by a number of recent oil and gas discoveries and a sustained government push for increased exploration. Our analyses reveal that the use of technical best practice could minimize future impacts by greatly reducing the amount of required infrastructure such as drilling platforms and access roads. We also document a critical need to consider more fully the ecological and social factors, as the vast majority of planned infrastructure overlaps sensitive areas such as protected areas, indigenous territories, and key ecosystems and watersheds. Lastly, our cost analysis indicates that following best practice does not impose substantially greater costs than conventional practice, and may in fact reduce overall costs. Barriers to the widespread implementation of best practice in the Amazon clearly exist, but our findings show that there can be great benefits to its implementation.

Impact of liver volume and liver function on posthepatectomy liver failure after portal vein embolization- A multivariable cohort analysis.

PubMed

Alizai, Patrick H; Haelsig, Annabel; Bruners, Philipp; Ulmer, Florian; Klink, Christian D; Dejong, Cornelis H C; Neumann, Ulf P; Schmeding, Maximilian

2018-01-01

Liver failure remains a life-threatening complication after liver resection, and is difficult to predict preoperatively. This retrospective cohort study evaluated different preoperative factors in regard to their impact on posthepatectomy liver failure (PHLF) after extended liver resection and previous portal vein embolization (PVE). Patient characteristics, liver function and liver volumes of patients undergoing PVE and subsequent liver resection were analyzed. Liver function was determined by the LiMAx test (enzymatic capacity of cytochrome P450 1A2). Factors associated with the primary end point PHLF (according to ISGLS definition) were identified through multivariable analysis. Secondary end points were 30-day mortality and morbidity. 95 patients received PVE, of which 64 patients underwent major liver resection. PHLF occurred in 7 patients (11%). Calculated postoperative liver function was significantly lower in patients with PHLF than in patients without PHLF (67 vs. 109 μg/kg/h; p = 0.01). Other factors associated with PHLF by univariable analysis were age, future liver remnant, MELD score, ASA score, renal insufficiency and heart insufficiency. By multivariable analysis, future liver remnant was the only factor significantly associated with PHLF (p = 0.03). Mortality and morbidity rates were 4.7% and 29.7% respectively. Future liver remnant is the only preoperative factor with a significant impact on PHLF. Assessment of preoperative liver function may additionally help identify patients at risk for PHLF.

Factors Controlling Vegetation Fires in Protected and Non-Protected Areas of Myanmar

PubMed Central

Biswas, Sumalika; Vadrevu, Krishna Prasad; Lwin, Zin Mar; Lasko, Kristofer; Justice, Christopher O.

2015-01-01

Fire is an important disturbance agent in Myanmar impacting several ecosystems. In this study, we quantify the factors impacting vegetation fires in protected and non-protected areas of Myanmar. Satellite datasets in conjunction with biophysical and anthropogenic factors were used in a spatial framework to map the causative factors of fires. Specifically, we used the frequency ratio method to assess the contribution of each causative factor to overall fire susceptibility at a 1km scale. Results suggested the mean fire density in non-protected areas was two times higher than the protected areas. Fire-land cover partition analysis suggested dominant fire occurrences in the savannas (protected areas) and woody savannas (non-protected areas). The five major fire causative factors in protected areas in descending order include population density, land cover, tree cover percent, travel time from nearest city and temperature. In contrast, the causative factors in non-protected areas were population density, tree cover percent, travel time from nearest city, temperature and elevation. The fire susceptibility analysis showed distinct spatial patterns with central Myanmar as a hot spot of vegetation fires. Results from propensity score matching suggested that forests within protected areas have 11% less fires than non-protected areas. Overall, our results identify important causative factors of fire useful to address broad scale fire risk concerns at a landscape scale in Myanmar. PMID:25909632

Factors controlling vegetation fires in protected and non-protected areas of myanmar.

PubMed

Biswas, Sumalika; Vadrevu, Krishna Prasad; Lwin, Zin Mar; Lasko, Kristofer; Justice, Christopher O

2015-01-01

Fire is an important disturbance agent in Myanmar impacting several ecosystems. In this study, we quantify the factors impacting vegetation fires in protected and non-protected areas of Myanmar. Satellite datasets in conjunction with biophysical and anthropogenic factors were used in a spatial framework to map the causative factors of fires. Specifically, we used the frequency ratio method to assess the contribution of each causative factor to overall fire susceptibility at a 1km scale. Results suggested the mean fire density in non-protected areas was two times higher than the protected areas. Fire-land cover partition analysis suggested dominant fire occurrences in the savannas (protected areas) and woody savannas (non-protected areas). The five major fire causative factors in protected areas in descending order include population density, land cover, tree cover percent, travel time from nearest city and temperature. In contrast, the causative factors in non-protected areas were population density, tree cover percent, travel time from nearest city, temperature and elevation. The fire susceptibility analysis showed distinct spatial patterns with central Myanmar as a hot spot of vegetation fires. Results from propensity score matching suggested that forests within protected areas have 11% less fires than non-protected areas. Overall, our results identify important causative factors of fire useful to address broad scale fire risk concerns at a landscape scale in Myanmar.

The impact of socioeconomic factors on municipal solid waste generation in São Paulo, Brazil.

PubMed

Vieira, Victor H Argentino de Morais; Matheus, Dácio R

2018-01-01

Social factors have not been sufficiently explored in municipal solid waste management studies. Latin America has produced even fewer studies with this approach; technical and economic investigations have prevailed. We explored the impacts of socioeconomic factors on municipal solid waste generation in Greater Sao Paulo, which includes 39 municipalities. We investigated the relations between municipal solid waste generation and social factors by Pearson's correlation coefficient. The Student's t-test (at p ← 0.01) proved significance, and further regression analysis was performed with significant factors. We considered 10 socioeconomic factors: population, rural population, density, life expectancy, education (secondary, high and undergraduate level), income per capita, inequality and human development. A later multicollinearity analysis resulted in the determination of inequality (r p = 0.625) and income per capita (r p = 0.607) as major drivers. The results showed the relevance of considering social aspects in municipal solid waste management and isolated inequality as an important factor in planning. Inequality must be used as a complementary factor to income, rather than being used exclusively. Inequality may explain differences of waste generation between areas with similar incomes because of consumption patterns. Therefore, unequal realities demand unequal measures to avoid exacerbation, for example, pay-as-you-throw policies instead of uniform fees. Unequal realities also highlight the importance of tiering policies beyond the waste sector, such as sustainable consumption.

Representation of Nursing Scientists from German-speaking countries in High Impact Journals. A bibliometric publication analysis

PubMed

Hirt, Julian; Buhtz, Christian; Mersdorf, Benedikt; Meyer, Gabriele

2018-02-01

Background: The frequency of publications by nursing scientists from the German-speaking area in journals with a high impact factor is an indicator for participation of the discipline in the international discourse. Previous publication analyses focused on nursing science journals only and regularly found an underrepresentation of experimental studies and clinical topics. Aim: To identify and analyse the number of publications by nursing scientists from Germany, Austria and German-speaking Switzerland in international high impact journals. Method: The Journal Citation Reports were used to identify nursing relevant categories of journals in which the highest 10 % of the years 2010 to 2014 were selected according to the 5-year Impact Factor. Inclusion of publications and data extraction were carried out by two independent persons. Results: 106939 publications from 126 journals were screened; 100 publications were identified with 229 contributions by 114 nursing scientists. 42 % of studies are observational and 11 % are experimental. The majority of studies are clinically oriented (55 %). More than 50 % have been published in the past two years. Conclusions: The number of publications by nursing scientists from the German-speaking countries in High Impact Journals is low. There is an increase throughout the observation period. In opposite to former analyses a higher proportion of clinical research has been found.

Predictors of the Onset of Manic Symptoms and a (Hypo)Manic Episode in Patients with Major Depressive Disorder

PubMed Central

Boschloo, Lynn; Spijker, Annet T.; Hoencamp, Erik; Kupka, Ralph; Nolen, Willem A.; Schoevers, Robert A.; Penninx, Brenda W. J. H.

2014-01-01

Objective One third of patients with a major depressive episode also experience manic symptoms or, even, a (hypo)manic episode. Retrospective studies on the temporal sequencing of symptomatology suggest that the majority of these patients report depressive symptoms before the onset of manic symptoms. However, prospective studies are scarce and this study will, therefore, prospectively examine the onset of either manic symptoms or a (hypo)manic episode in patients with a major depressive disorder. In addition, we will consider the impact of a large set of potential risk factors on both outcomes. Methodology Four-year follow-up data were used to determine the onset of manic symptoms as well as a CIDI-based (hypo)manic episode in a large sample (n = 889, age: 18–65 years) of outpatients with a major depressive disorder and without manic symptoms at baseline. Baseline vulnerability (i.e., sociodemographics, family history of depression, childhood trauma, life-events) and clinical (i.e., isolated manic symptoms, depression characteristics, and psychiatric comorbidity) factors were considered as potential risk factors. Results In our sample of depressed patients, 15.9% developed manic symptoms and an additional 4.7% developed a (hypo)manic episode during four years. Baseline isolated manic symptoms and comorbid alcohol dependence predicted both the onset of manic symptoms and a (hypo)manic episode. Low education only predicted the onset of manic symptoms, whereas male gender, childhood trauma and severity of depressive symptoms showed strong associations with, especially, the onset of (hypo)manic episodes. Conclusions A substantial proportion (20.6%) of patients with a major depressive disorder later developed manic symptoms or a (hypo)manic episode. Interestingly, some identified risk factors differed for the two outcomes, which may indicate that pathways leading to the onset of manic symptoms or a (hypo)manic episode might be different. Our findings indirectly support a clinical staging model. PMID:25259889

Predictors of the onset of manic symptoms and a (hypo)manic episode in patients with major depressive disorder.

PubMed

Boschloo, Lynn; Spijker, Annet T; Hoencamp, Erik; Kupka, Ralph; Nolen, Willem A; Schoevers, Robert A; Penninx, Brenda W J H

2014-01-01

One third of patients with a major depressive episode also experience manic symptoms or, even, a (hypo)manic episode. Retrospective studies on the temporal sequencing of symptomatology suggest that the majority of these patients report depressive symptoms before the onset of manic symptoms. However, prospective studies are scarce and this study will, therefore, prospectively examine the onset of either manic symptoms or a (hypo)manic episode in patients with a major depressive disorder. In addition, we will consider the impact of a large set of potential risk factors on both outcomes. Four-year follow-up data were used to determine the onset of manic symptoms as well as a CIDI-based (hypo)manic episode in a large sample (n = 889, age: 18-65 years) of outpatients with a major depressive disorder and without manic symptoms at baseline. Baseline vulnerability (i.e., sociodemographics, family history of depression, childhood trauma, life-events) and clinical (i.e., isolated manic symptoms, depression characteristics, and psychiatric comorbidity) factors were considered as potential risk factors. In our sample of depressed patients, 15.9% developed manic symptoms and an additional 4.7% developed a (hypo)manic episode during four years. Baseline isolated manic symptoms and comorbid alcohol dependence predicted both the onset of manic symptoms and a (hypo)manic episode. Low education only predicted the onset of manic symptoms, whereas male gender, childhood trauma and severity of depressive symptoms showed strong associations with, especially, the onset of (hypo)manic episodes. A substantial proportion (20.6%) of patients with a major depressive disorder later developed manic symptoms or a (hypo)manic episode. Interestingly, some identified risk factors differed for the two outcomes, which may indicate that pathways leading to the onset of manic symptoms or a (hypo)manic episode might be different. Our findings indirectly support a clinical staging model.

Differential Impact of LPG-and PG-Deficient Leishmania major Mutants on the Immune Response of Human Dendritic Cells

PubMed Central

Jayakumar, Asha; Hickerson, Suzanne; Mostrom, Janet; Turco, Salvatore J.; Beverley, Stephen M.; McDowell, Mary Ann

2015-01-01

Background Leishmania major infection induces robust interleukin-12 (IL12) production in human dendritic cells (hDC), ultimately resulting in Th1-mediated immunity and clinical resolution. The surface of Leishmania parasites is covered in a dense glycocalyx consisting of primarily lipophosphoglycan (LPG) and other phosphoglycan-containing molecules (PGs), making these glycoconjugates the likely pathogen-associated molecular patterns (PAMPS) responsible for IL12 induction. Methodology/Principal Findings Here we explored the role of parasite glycoconjugates on the hDC IL12 response by generating L. major Friedlin V1 mutants defective in LPG alone, (FV1 lpg1-), or generally deficient for all PGs, (FV1 lpg2-). Infection with metacyclic, infective stage, L. major or purified LPG induced high levels of IL12B subunit gene transcripts in hDCs, which was abrogated with FV1 lpg1- infections. In contrast, hDC infections with FV1 lpg2- displayed increased IL12B expression, suggesting other PG-related/LPG2 dependent molecules may act to dampen the immune response. Global transcriptional profiling comparing WT, FV1 lpg1-, FV1 lpg2- infections revealed that FV1 lpg1- mutants entered hDCs in a silent fashion as indicated by repression of gene expression. Transcription factor binding site analysis suggests that LPG recognition by hDCs induces IL-12 in a signaling cascade resulting in Nuclear Factor κ B (NFκB) and Interferon Regulatory Factor (IRF) mediated transcription. Conclusions/Significance These data suggest that L. major LPG is a major PAMP recognized by hDC to induce IL12-mediated protective immunity and that there is a complex interplay between PG-baring Leishmania surface glycoconjugates that result in modulation of host cellular IL12. PMID:26630499

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thorhaug, A.

The major focus was to understand the function of the seagrass community and to relate this to the impact of energy related activities, most importantly, thermal effluent. In addition, the increased turbidity, current, siltation and heavy metals were factors at the Turkey Point site. We attempted to delineate the effect of heat in the laboratory to determine the upper thermal tolerance of the seagrass. This was shown to be quite close to the combined effect of all the pollutants in the field for Thalassia and the macroalgae. This would indicate that temperature is a very fundamental factor in the growthmore » and survival of the seagrass community.« less

Incidence and risk factors of injuries and their impact on academic success: A prospective study in PETE students.

PubMed

Bliekendaal, S; Goossens, L; Stubbe, J H

2017-12-01

Injuries can have a major impact on the physical performance and academic career of physical education teacher education (PETE) students. To investigate the injury problem, risk factors, and the impact of injuries on academic success, 252 PETE students were followed during their first semester. Risk factor analysis was conducted by means of logistic regression analysis with a differentiation for upper body, lower body, acute, overuse, and severe injuries. An incidence of 1.26 injuries/student/semester was found. Most injuries involved the lower body (61%), were new injuries (76%), occurred acutely (66%), and were sustained during curricular gymnastics (25%) or extracurricular soccer (28%). Significant risk factors for lower body acute injuries were age (OR=2.14; P=.01), previous injury (OR=2.23; P=.01), and an injury at the start of the year (OR=2.56; P=.02). For lower body overuse injuries, gender (OR=2.85; P=.02) and the interval shuttle run test score (OR=2.44; P=.04) were significant risk factors. Previous injury (OR=2.59; P=.04) and injury at the start of the year (upper body: OR=4.57; P=.02; lower body: OR=3.75; P<.01) were risk factors for severe injuries. Injury-related time loss was positively related to total academic success (r=.20; P=.02) and success in theoretical courses (r=.24; P=<.01). No association was found between time loss and academic success for sport courses. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Prognostic importance of DNA ploidy in non-endometrioid, high-risk endometrial carcinomas.

PubMed

Sorbe, Bengt

2016-03-01

The present study investigated the predictive and prognostic impact of DNA ploidy together with other well-known prognostic factors in a series of non-endometrioid, high-risk endometrial carcinomas. From a complete consecutive series of 4,543 endometrial carcinomas of International Federation of Gynecology and Obstetrics (FIGO) stages I-IV, 94 serous carcinomas, 48 clear cell carcinomas and 231 carcinosarcomas were selected as a non-endometrioid, high-risk group for further studies regarding prognosis. The impact of DNA ploidy, as assessed by flow cytometry, was of particular focus. The age of the patients, FIGO stage, depth of myometrial infiltration and tumor expression of p53 were also included in the analyses (univariate and multivariate). In the complete series of cases, the recurrence rate was 37%, and the 5-year overall survival rate was 39% with no difference between the three histological subtypes. The primary cure rate (78%) was also similar for all tumor types studied. DNA ploidy was a significant predictive factor (on univariate analysis) for primary tumor cure rate, and a prognostic factor for survival rate (on univariate and multivariate analyses). The predictive and prognostic impact of DNA ploidy was higher in carcinosarcomas than in serous and clear cell carcinomas. In the majority of multivariate analyses, FIGO stage and depth of myometrial infiltration were the most important predictive (tumor recurrence) and prognostic (survival rate) factors. DNA ploidy status is a less important predictive and prognostic factor in non-endometrioid, high-risk endometrial carcinomas than in the common endometrioid carcinomas, in which FIGO and nuclear grade also are highly significant and important factors.

The Impact of Smoking on Airflow Limitation in Subjects with History of Asthma and Inactive Tuberculosis

PubMed Central

Kim, Hyun Jung; Baek, Seunghee; Kim, Hee Jin; Lee, Jae Seung; Oh, Yeon-Mok; Lee, Sang-Do; Lee, Sei Won

2015-01-01

Background Although smoking is the most important and modifiable cause of chronic obstructive pulmonary disease (COPD), other risk factors including asthma and tuberculosis (TB) are also associated. It is common for COPD patients to have more than one of these risk factors. The aims of this study were to determine the prevalence of airflow limitation (FEV1/FVC<0.7) according to the risk factors and to investigate their impact and interaction in airflow limitation. Methods From the Korean National Health and Nutrition Examination Survey between 2008 and 2012, we analyzed participants over 40 years of age by spirometry, chest radiograph and questionnaire about asthma and smoking history. Results Of 12,631 participants, 1,548 (12.3%) had airflow limitation. The prevalence of airflow limitation in smokers (≥10 pack-year), asthmatics, and those with inactive TB was 23.9%, 32.1%, and 33.6%. The prevalence increased with the number of risk factors: 86.1% had airflow limitation if they had all three risk factors. Impacts of inactive TB and asthma on airflow limitation were equivalent to 47 and 69 pack-years of smoking, respectively. Airflow limitation resulted from lower levels of smoking in those with inactive TB and asthma. A potential interaction between smoking and inactive tuberculosis in the development of airflow limitation was identified (p = 0.054). Conclusions Asthma and inactive TB lesions increase susceptibility to smoking in the development of airflow limitation. People with these risk factors should be seen as a major target population for anti-smoking campaigns to prevent COPD. PMID:25915938

Risk factors for postoperative complications in robotic general surgery.

PubMed

Fantola, Giovanni; Brunaud, Laurent; Nguyen-Thi, Phi-Linh; Germain, Adeline; Ayav, Ahmet; Bresler, Laurent

2017-03-01

The feasibility and safety of robotically assisted procedures in general surgery have been reported from various groups worldwide. Because postoperative complications may lead to longer hospital stays and higher costs overall, analysis of risk factors for postoperative surgical complications in this subset of patients is clinically relevant. The goal of this study was to identify risk factors for postoperative morbidity after robotic surgical procedures in general surgery. We performed an observational monocentric retrospective study. All consecutive robotic surgical procedures from November 2001 to December 2013 were included. One thousand consecutive general surgery patients met the inclusion criteria. The mean overall postoperative morbidity and major postoperative morbidity (Clavien >III) rates were 20.4 and 6 %, respectively. This included a conversion rate of 4.4 %, reoperation rate of 4.5 %, and mortality rate of 0.2 %. Multivariate analysis showed that ASA score >3 [OR 1.7; 95 % CI (1.2-2.4)], hematocrit value <38 [OR 1.6; 95 % CI (1.1-2.2)], previous abdominal surgery [OR 1.5; 95 % CI (1-2)], advanced dissection [OR 5.8; 95 % CI (3.1-10.6)], and multiquadrant surgery [OR 2.5; 95 % CI (1.7-3.8)] remained independent risk factors for overall postoperative morbidity. It also showed that advanced dissection [OR 4.4; 95 % CI (1.9-9.6)] and multiquadrant surgery [OR 4.4; 95 % CI (2.3-8.5)] remained independent risk factors for major postoperative morbidity (Clavien >III). This study identifies independent risk factors for postoperative overall and major morbidity in robotic general surgery. Because these factors independently impacted postoperative complications, we believe they could be taken into account in future studies comparing conventional versus robot-assisted laparoscopic procedures in general surgery.

Aging and the Pathogenic Response to Burn

PubMed Central

Rani, Meenakshi; Schwacha, Martin G.

2012-01-01

Aging is an important and critical factor that contributes to the clinical outcome of burn patients. The very young and the elderly are more likely to succumb after major burn as compared to their adult counterparts. With the aging population, improved understanding of the mechanisms underlying age-associated complications after burns becomes even more demanding. It is widely accepted that elderly burn patients have significantly increased morbidity and mortality. Irrespective of the type of burn injury, the aged population shows slower recoveries and suffers more complications. Age-associated immune dysfunction, immunosenescence, may predispose the elderly burn patients to more infections, slower healing and/or to other complications. Furthermore, pre-existing, age-related medical conditions such as, pulmonary/cardiovascular dysfunctions and diabetes in the elderly are other important factors that contribute to their poorer outcomes after major burn. The present review describes the impact of aging on burn patients outcomes. PMID:22724078

Response to therapeutic sleep deprivation: a naturalistic study of clinical and genetic factors and post-treatment depressive symptom trajectory.

PubMed

Trautmann, Nina; Foo, Jerome C; Frank, Josef; Witt, Stephanie H; Streit, Fabian; Treutlein, Jens; von Heydendorff, Steffen Conrad; Gilles, Maria; Forstner, Andreas J; Ebner-Priemer, Ulrich; Nöthen, Markus M; Deuschle, Michael; Rietschel, Marcella

2018-05-17

Research has shown that therapeutic sleep deprivation (SD) has rapid antidepressant effects in the majority of depressed patients. Investigation of factors preceding and accompanying these effects may facilitate the identification of the underlying biological mechanisms. This exploratory study aimed to examine clinical and genetic factors predicting response to SD and determine the impact of SD on illness course. Mood during SD was also assessed via visual analogue scale. Depressed inpatients (n = 78) and healthy controls (n = 15) underwent ~36 h of SD. Response to SD was defined as a score of ≤ 2 on the Clinical Global Impression Scale for Global Improvement. Depressive symptom trajectories were evaluated for up to a month using self/expert ratings. Impact of genetic burden was calculated using polygenic risk scores for major depressive disorder. In total, 72% of patients responded to SD. Responders and non-responders did not differ in baseline self/expert depression symptom ratings, but mood differed. Response was associated with lower age (p = 0.007) and later age at life-time disease onset (p = 0.003). Higher genetic burden of depression was observed in non-responders than healthy controls. Up to a month post SD, depressive symptoms decreased in both patients groups, but more in responders, in whom effects were sustained. The present findings suggest that re-examining SD with a greater focus on biological mechanisms will lead to better understanding of mechanisms of depression.

Variation in Treatment of Displaced Geriatric Acetabular Fractures Among 15 Level-I Trauma Centers.

PubMed

Manson, Theodore T; Reider, Lisa; OʼToole, Robert V; Scharfstein, Daniel O; Tornetta, Paul; Gary, Joshua L

2016-09-01

To document the initial treatment of displaced acetabular fractures among older adults across multiple trauma centers and to investigate the factors that influence the decision to operate and the choice of operative procedure [open reduction internal fixation (ORIF) vs. total hip arthroplasty (THA)]. Retrospective observational study. Fifteen US level-I trauma centers participating in the Major Extremity Trauma Research Consortium. Overall, 269 patients aged 60 years or older admitted for the treatment of a displaced acetabular fracture. None. Treatment. Sixty percent of fractures (n = 162) were treated operatively. Younger age (<80 years), injury from high-energy mechanism, fractures with femoral head impaction, and fractures without hip congruency were significantly associated with receiving operative treatment (P < 0.05). Significant site variation in operative versus nonoperative treatment occurred even after accounting for these factors (P = 0.0044). Among operatively treated patients, 88% (n = 142) received ORIF and 12% (n = 20) received THA as the initial treatment. Women were more likely to be treated with initial THA compared with men; of the known risk factors for poor outcomes with ORIF (ie, dome or roof impaction, femoral head impaction, or posterior wall involvement), only dome impaction was significantly associated with receiving initial THA (P < 0.05). Currently, no treatment guidelines exist for acetabular fractures in older adults, which likely explains the significant site variation in operative versus nonoperative treatment. This study identifies patient and injury factors that drive treatment decisions, which will be important in planning and designing future trials needed to determine the best treatment for these fractures.

The effects of food allergy on quality of life.

PubMed

DunnGalvin, Audrey; Dubois, A E J; Flokstra-de Blok, B M J; Hourihane, J O'B

2015-01-01

The majority of research on food allergy has been bio-medical in orientation, focusing on issues such as the molecular structure of allergens, or aimed at methods of diagnosis. In the last decade, there has been a growing interest in the development of questionnaires that measure the impact of food allergy on health-related quality of life (HRQL). These studies have provided insight into the everyday burden of living with food allergy and have suggested ways that HRQL can be improved. The EuroPrevall project (europrevall@bbsrc.ac.uk) has given great impetus to research in the area of HRQL. In addition to clinical research on the prevalence, mechanisms and causes of food allergy, research output in the area of psycho-social impact has included HRQL measures for all age groups and examination of the socio-economic impact of food allergy. In this chapter, we review the literature on the impact of food allergy on children, teens and their parents; the majority of this data was generated over the life of the EuroPrevall project. We then examine both quantitative and qualitative research findings to provide an in-depth picture of the impact of food allergy on the concerns and everyday lives of children, teens, adults and parents. Research on factors that are related to and impact HRQL is also discussed. There is a strong emphasis throughout the chapter on developmental considerations of food allergy, spanning from infants to adults. We conclude by discussing methodological issues in relation to the measurement of HRQL in relation to food allergy. We offer some recommendations for future research and practice on HRQL so that HRQL measures can reach their full potential in research, practice and policy, with the help of the findings in this review. Overall, the findings suggest that food allergy has a strong impact on HRQL in terms of social, dietary, and psychological factors. 'Rules' and restrictions ostensibly apply to food, but because food is such an integral part of everyday life, these restrictions extend far beyond 'mealtimes'. Therefore, social events are experienced differently and have a different meaning for those living with food allergy, giving rise to feelings of exclusion and difference when compared to those without allergy. Children, teens, and parents need to cope with normal developmental changes as well as with the food allergy, placing them under increased psycho-social stress and leading to adverse effects on HRQL and coping. To address and attempt to alleviate such stressors, both quantitative and qualitative research suggests that targeting uncertainty should be a major goal for health professionals working with children, teens and families with a food allergy. Remarkable similarities in response to food allergy across countries suggest that policies and programmes that address quality of life issues may be relevant to many different populations. An in-depth understanding of the relationship between a diagnosis of food allergy and HRQL, as well as the factors that impact it, will ultimately lead to the promotion of earlier, more effective preventive strategies and interventions that are focused on maximising optimal health development and quality of life. © 2015 S. Karger AG, Basel.

Splicing factor gene mutations in the myelodysplastic syndromes: impact on disease phenotype and therapeutic applications.

PubMed

Pellagatti, Andrea; Boultwood, Jacqueline

2017-01-01

Splicing factor gene mutations are the most frequent mutations found in patients with the myeloid malignancy myelodysplastic syndrome (MDS), suggesting that spliceosomal dysfunction plays a major role in disease pathogenesis. The aberrantly spliced target genes and deregulated cellular pathways associated with the commonly mutated splicing factor genes in MDS (SF3B1, SRSF2 and U2AF1) are being identified, illuminating the molecular mechanisms underlying MDS. Emerging data from mouse modeling studies indicate that the presence of splicing factor gene mutations can lead to bone marrow hematopoietic stem/myeloid progenitor cell expansion, impaired hematopoiesis and dysplastic differentiation that are hallmarks of MDS. Importantly, recent evidence suggests that spliceosome inhibitors and splicing modulators may have therapeutic value in the treatment of splicing factor mutant myeloid malignancies. Copyright © 2016 Elsevier Ltd. All rights reserved.

Diffraction analysis of sidelobe characteristics of optical elements with ripple error

NASA Astrophysics Data System (ADS)

Zhao, Lei; Luo, Yupeng; Bai, Jian; Zhou, Xiangdong; Du, Juan; Liu, Qun; Luo, Yujie

2018-03-01

The ripple errors of the lens lead to optical damage in high energy laser system. The analysis of sidelobe on the focal plane, caused by ripple error, provides a reference to evaluate the error and the imaging quality. In this paper, we analyze the diffraction characteristics of sidelobe of optical elements with ripple errors. First, we analyze the characteristics of ripple error and build relationship between ripple error and sidelobe. The sidelobe results from the diffraction of ripple errors. The ripple error tends to be periodic due to fabrication method on the optical surface. The simulated experiments are carried out based on angular spectrum method by characterizing ripple error as rotationally symmetric periodic structures. The influence of two major parameter of ripple including spatial frequency and peak-to-valley value to sidelobe is discussed. The results indicate that spatial frequency and peak-to-valley value both impact sidelobe at the image plane. The peak-tovalley value is the major factor to affect the energy proportion of the sidelobe. The spatial frequency is the major factor to affect the distribution of the sidelobe at the image plane.

Examination of the interrelations between the factors of PTSD, major depression, and generalized anxiety disorder in a heterogeneous trauma-exposed sample using DSM 5 criteria.

PubMed

Price, Matthew; van Stolk-Cooke, Katherine

2015-11-01

Exposure to traumatic events places individuals at high risk for multiple psychiatric disorders, including posttraumatic stress disorder (PTSD), major depressive disorder (MDD), and generalized anxiety disorder (GAD). The high rates of comorbidity among these conditions merit evaluation in order to improve diagnosis and treatment approaches. The current study evaluated the association between PTSD, MDD, and GAD factors as presented in the DSM 5. 602 trauma-exposed individuals who experienced an event that met Criterion A for the DSM 5 PTSD diagnosis were recruited through Amazon.com, Inc.'s Mechanical Turk (MTurk) to complete an assessment of the impact of stressful events on their lives. High interrelations were detected among the 4 PTSD factors, 2 MDD factors that corresponded to somatic and affective symptoms, and the single GAD factor. The affective factor of MDD was most strongly related to the emotional numbing factor of PTSD, whereas the somatic factor of MDD was most strongly related to the hyperarousal factor of PTSD. The GAD factor was most strongly related to the hyperarousal factor of PTSD, relative to the other PTSD factors. The strength of the interrelations between factors of the three disorders is largely a function of the overlap in symptoms and calls into question the uniqueness of negative affective symptoms of PTSD, MDD and GAD. Results suggest that improved understanding of the trauma reaction requires a focus on the unique presentation of each individual and assessment of multiple disorders. Copyright © 2015 Elsevier B.V. All rights reserved.

Age-Related Alterations in Signaling Pathways in Articular Chondrocytes: Implications for the Pathogenesis and Progression of Osteoarthritis - A Mini-Review.

PubMed

van der Kraan, Peter; Matta, Csaba; Mobasheri, Ali

2017-01-01

Musculoskeletal conditions are a major burden on individuals, healthcare systems, and social care systems throughout the world, with indirect costs having a predominant economic impact. Aging is a major contributing factor to the development and progression of arthritic and musculoskeletal diseases. Indeed, aging and inflammation (often referred to as 'inflammaging') are critical risk factors for the development of osteoarthritis (OA), which is one of the most common forms of joint disease. The term 'chondrosenescence' has recently been introduced to define the age-dependent deterioration of chondrocyte function and how it undermines cartilage function in OA. An important component of chondrosenescence is the age-related deregulation of subcellular signaling pathways in chondrocytes. This mini-review discusses the role of age-related alterations in chondrocyte signaling pathways. We focus our attention on two major areas: age-dependent alterations in transforming growth factor-β signaling and changes in protein kinase and phosphoprotein phosphatase activities in aging chondrocytes. A better understanding of the basic signaling mechanisms underlying aging in chondrocytes is likely to facilitate the development of new therapeutic and preventive strategies for OA and a range of other age-related osteoarticular disorders. © 2016 The Author(s) Published by S. Karger AG, Basel.

Global changes: Impacts on habitability. A scientific basis for assessment

NASA Technical Reports Server (NTRS)

Goody, R.

1982-01-01

The feasibility of a major NASA research initiative to document, to understand, and if possible, to predict long-term (5 to 50 years) global changes that can affect the habitability of the Earth is addressed. The major factor contributing to change is human activity. The program discussed involves studies of the atmosphere, oceans, land, the cryosphere, and the biosphere. On decadal time scales, these regimes and the cycles of physical and chemical entities through them are coupled into a single interlocking system. Some part of this system can be studied in a straightforward manner (the atmosphere) and some with great difficulty (the biosphere).

Cancer in the Transplant Recipient

PubMed Central

Chapman, Jeremy R.; Webster, Angela C.; Wong, Germaine

2013-01-01

Malignancy has become one of the three major causes of death after transplantation in the past decade and is thus increasingly important in all organ transplant programs. Death from cardiovascular disease and infection are both decreasing in frequency from a combination of screening, prophylaxis, aggressive risk factor management, and interventional therapies. Cancer, on the other hand, is poorly and expensively screened for; risk factors are mostly elusive and/or hard to impact on except for the use of immunosuppression itself; and finally therapeutic approaches to the transplant recipient with cancer are often nihilistic. This article provides a review of each of the issues as they come to affect transplantation: cancer before wait-listing, cancer transmission from the donor, cancer after transplantation, outcomes of transplant recipients after a diagnosis of cancer, and the role of screening and therapy in reducing the impact of cancer in transplant recipients. PMID:23818517

Of Horse Race and Policy Issues: A Study of Gender in Coverage of a Gubernatorial Election by Two Major Metropolitan Newspapers.

ERIC Educational Resources Information Center

Serini, Shirley A.; Powers, Angela A.; Johnson, Susan

1998-01-01

Examines media coverage of a gubernatorial election, suggesting that: (1) gender may be a larger factor in selecting policy stories over "horse race" stories; (2) coverage of the horse race has greater impact on election outcome than coverage of policy issues; and (3) a woman will be more successful in an election if she presents herself…

Leading the rebirth of the rural obstetrician.

PubMed

Campbell, Alison M; Brown, James; Simon, David R; Young, Sari; Kinsman, Leigh

2014-12-11

To understand the factors influencing the decisions of rural general practitioners and GP registrars to practise obstetrics, and to understand the impact on these decisions of an innovative obstetric training and support program in the Gippsland region of Victoria. Qualitative approach using semistructured interviews conducted in July and August 2013 and inductive content analysis. Participants were identified from training records over the previous 5 years for the Gippsland GP obstetric training and support program. Two questions were posed during interviews: What challenges face rural GPs in practising obstetrics? What impact has the Gippsland GP obstetric program had on GP obstetric career decisions? Of 60 people invited to participate, 22 agreed. Interviews ranged in duration from 40 to 90 minutes. The major themes that emerged on the challenges facing rural GPs in practising obstetrics were isolation, work-life balance and safety. The major themes that emerged on the impact of the Gippsland GP obstetric program were professional support, structured training and effective leadership. Rural GP obstetricians are challenged by isolation, the impact of their job on work-life balance, and safety. The support, training and leadership offered by the Gippsland expanded obstetric training program helped doctors to deal with these challenges. The Gippsland model of training offers a template for GP obstetric procedural training programs for other rural settings.

Electrocardiographic Presentation, Cardiac Arrhythmias, and Their Management in β-Thalassemia Major Patients.

PubMed

Russo, Vincenzo; Rago, Anna; Papa, Andrea Antonio; Nigro, Gerardo

2016-07-01

Beta-thalassemia major (β-TM) is a genetic hemoglobin disorder characterized by an absent synthesis of globin chains that are essential for hemoglobin formation, causing chronic hemolytic anemia. Clinical management of thalassemia major consists in regular long-life red blood cell transfusions and iron chelation therapy to remove iron introduced in excess with transfusions. Iron deposition in combination with inflammatory and immunogenic factors is involved in the pathophysiology of cardiac dysfunction in these patients. Heart failure and arrhythmias, caused by myocardial siderosis, are the most important life-limiting complications of iron overload in beta-thalassemia patients. Cardiac complications are responsible for 71% of global death in the beta-thalassemia major patients. The aim of this review was to describe the most frequent electrocardiographic abnormalities and arrhythmias observed in β-TM patients, analyzing their prognostic impact and current treatment strategies. © 2016 Wiley Periodicals, Inc.

Trends in impact factors of ophthalmology journals.

PubMed

Vainer, Igor; Mimouni, Francis; Blumenthal, Eytan Z; Mimouni, Michael

2016-09-01

To test whether there is an association between the growth in the number of ophthalmic journals in the past years and their mean and maximum impact factor (IF) as a common sign of scientific proliferation. Using data from the 2013 Journal Citation Report database a study of the major clinical medical fields was conducted to assess the correlation between the number of journals and maximum IF in a given field in the year 2013. In the field of ophthalmology, we examined the correlation between year, number of journals, mean IF and maximum IF in the field of ophthalmology throughout the years 2000-2013. In the major medical fields, a positive correlation was found between the number of journals and the maximum IF (quadratic R2 = 0.71, P< 0.001). When studying the field of ophthalmology a positive correlation between the number of journals and mean IF (R2 = 0.84, P< 0.001) and between number of journals and maximum IF (R2 = 0.71, P< 0.001) was detected. Our findings suggest that the variation in the IF can be explained by the number of journals in the field of ophthalmology. In the future, the formation of additional ophthalmology journals is likely to further increase the IFs of existing journals.

Trends in impact factors of ophthalmology journals

PubMed Central

Vainer, Igor; Mimouni, Francis; Blumenthal, Eytan Z; Mimouni, Michael

2016-01-01

Purpose: To test whether there is an association between the growth in the number of ophthalmic journals in the past years and their mean and maximum impact factor (IF) as a common sign of scientific proliferation. Methods: Using data from the 2013 Journal Citation Report database a study of the major clinical medical fields was conducted to assess the correlation between the number of journals and maximum IF in a given field in the year 2013. In the field of ophthalmology, we examined the correlation between year, number of journals, mean IF and maximum IF in the field of ophthalmology throughout the years 2000–2013. Results: In the major medical fields, a positive correlation was found between the number of journals and the maximum IF (quadratic R2 = 0.71, P < 0.001). When studying the field of ophthalmology a positive correlation between the number of journals and mean IF (R2 = 0.84, P < 0.001) and between number of journals and maximum IF (R2 = 0.71, P < 0.001) was detected. Conclusions: Our findings suggest that the variation in the IF can be explained by the number of journals in the field of ophthalmology. In the future, the formation of additional ophthalmology journals is likely to further increase the IFs of existing journals. PMID:27853016

Vitamin K antagonist use: evidence of the difficulty of achieving and maintaining target INR range and subsequent consequences.

PubMed

Schein, Jeff R; White, C Michael; Nelson, Winnie W; Kluger, Jeffrey; Mearns, Elizabeth S; Coleman, Craig I

2016-01-01

Vitamin K antagonists (VKAs) are effective oral anticoagulants that are titrated to a narrow therapeutic international normalized ratio (INR) range. We reviewed published literature assessing the impact of INR stability - getting into and staying in target INR range - on outcomes including thrombotic events, major bleeding, and treatment costs, as well as key factors that impact INR stability. A time in therapeutic range (TTR) of ≥65 % is commonly accepted as the definition of INR stability. In the real-world setting, this is seldom achieved with standard-of-care management, thus increasing the patients' risks of thrombotic or major bleeding events. There are many factors associated with poor INR control. Being treated in community settings, newly initiated on a VKA, younger in age, or nonadherent to therapy, as well as having polymorphisms of CYP2C9 or VKORC1, or multiple physical or mental co-morbid disease states have been associated with lower TTR. Clinical prediction tools are available, though they can only explain <10 % of the variance behind poor INR control. Clinicians caring for patients who require anticoagulation are encouraged to intensify diligence in INR management when using VKAs and to consider appropriate use of newer anticoagulants as a therapeutic option.

Attachment style moderates theory of mind abilities in depression.

PubMed

Koelkebeck, Katja; Liedtke, Carla; Kohl, Waldemar; Alferink, Judith; Kret, Mariska Esther

2017-04-15

Being able to understand other people's emotions and intentions is crucial for social interactions and well-being. Deficits in theory of mind (ToM) functioning hamper this ability and have been observed in depression and other neuropsychiatric disorders. However, results of previous research in depression have been inconclusive, possibly due to the presence of comorbid disorders and the disregarding of other modulating factors. Thirty-eight patients with a major depressive disorder (MDD) and forty healthy matched controls were assessed with a ToM task using animated triangles. Results were correlated with attachment styles, empathy abilities and neurocognitive performance. Our findings show that 1) healthy female controls performed significantly stronger on the ToM task than female MDD patients, 2) these performance differences were driven by attachment styles and 3) depression severity did not impact task performance. The pharmacological treatment of the majority of patients might limit the generalizability of this study. Results indicate a gender-specific impact of attachment styles on ToM performance. Future studies should investigate whether impairments in social cognitive tasks pose a risk factor for depression and/or interactional styles or vice versa. Moreover, with regard to remediation programs gender-specific needs should be taken into account. Copyright © 2017 Elsevier B.V. All rights reserved.

Psychosocial aspects of diabetes management: dilemma of diabetes distress

PubMed Central

Tareen, Kinza

2017-01-01

Diabetes mellitus (DM) is a debilitating chronic illness with complex pathophysiological, psychological, and quality of life (QoL) implications creating a constant state of turbulence. Some of these interconnections are apparent to healthcare providers and are easily addressed in a routine diabetic clinical care. However, a large number of these hidden factors that interplay with each other and impact on the physical outcomes of DM goes unnoticed by health care providers. This is a frustrating and lonely predicament for DM patients making it very difficult for them to manage their illness well. At times these patients are mislabeled as “difficult patients”. In other cases they are considered to have and unnecessarily treated for psychiatric illness like depression, other mood or anxiety spectrum disorders which they may not need. In recent years clinical researcher are making strides in understanding the emotional distress a DM patient may feel and the factors contributing or perpetuating diabetes distress. This article focuses on understanding the diabetes distress and how it impacts our patients, how to screen, assess, treat and eventually prevent it from happening. The paper also attempt to bring out the major differences between diabetes distress and common psychiatric comorbidities of DM including but not limiting to major depressive disorder and other depression spectrum disorders. PMID:29184819

Depression in Racial and Ethnic Minorities: the Impact of Nativity and Discrimination.

PubMed

Budhwani, Henna; Hearld, Kristine Ria; Chavez-Yenter, Daniel

2015-03-01

This research examines factors associated with lifetime major depressive disorder in racial and ethnic minorities residing in the USA, with an emphasis on the impact of nativity, discrimination, and health lifestyle behaviors. The Healthy Migrant Effect and Health Lifestyle Theory were used to inform the design of this project. The use of these frameworks not only provides insightful results but also expands their application in mental health disparities research. Logistic regression models were implemented to examine risk factors associated with lifetime major depressive disorder, comparing immigrants to their American-born counterparts as well as to American-born Whites. Data were derived from the Collaborative Psychiatric Epidemiology Surveys (n = 17,249). Support was found for the hypothesis that certain immigrants, specifically Asian and Afro-Caribbean, have lower odds of depression as compared their non-immigrant counterparts. Although, Hispanic immigrants directionally had lower odds of depression, this finding was not statistically significant. Furthermore, engaging in excessive alcohol consumption was associated with higher rates of depression (odds ratio (OR) = 2.09, p < 0.001), and the effect of discrimination on depression was found to be significant, even when controlling for demographics. Of all racial and ethnic groups, foreign-born Afro-Caribbeans had the lowest rate of depression at 7 % followed by foreign-born Asians at 8 %.

Sex similarities and differences in risk factors for recurrence of major depression.

PubMed

van Loo, Hanna M; Aggen, Steven H; Gardner, Charles O; Kendler, Kenneth S

2017-11-27

Major depression (MD) occurs about twice as often in women as in men, but it is unclear whether sex differences subsist after disease onset. This study aims to elucidate potential sex differences in rates and risk factors for MD recurrence, in order to improve prediction of course of illness and understanding of its underlying mechanisms. We used prospective data from a general population sample (n = 653) that experienced a recent episode of MD. A diverse set of potential risk factors for recurrence of MD was analyzed using Cox models subject to elastic net regularization for males and females separately. Accuracy of the prediction models was tested in same-sex and opposite-sex test data. Additionally, interactions between sex and each of the risk factors were investigated to identify potential sex differences. Recurrence rates and the impact of most risk factors were similar for men and women. For both sexes, prediction models were highly multifactorial including risk factors such as comorbid anxiety, early traumas, and family history. Some subtle sex differences were detected: for men, prediction models included more risk factors concerning characteristics of the depressive episode and family history of MD and generalized anxiety, whereas for women, models included more risk factors concerning early and recent adverse life events and socioeconomic problems. No prominent sex differences in risk factors for recurrence of MD were found, potentially indicating similar disease maintaining mechanisms for both sexes. Course of MD is a multifactorial phenomenon for both males and females.

The impact of premature menopause on women's experience of self.

PubMed

Pasquali, E A

1999-12-01

Surgically or chemically induced premature menopause may have an impact on women's sense of self: the physical, psychological, social, and spiritual sense of self. This ethnographic research study explores the major factors that assaulted prematurely menopausal women's concept of self and the ways in which they attempted to readjust that concept. A unifying domain, evolution of self, and three constitutive themes emerged: change/loss, connectedness/disconnectedness, and transcendence/transformation. A holistic nurse-client relationship that transcends the hospital experience and extends into the community may help prematurely menopausal women to move toward a more synthesized sense of self and a greater degree of self-actualization.

The Impact of Microbiota-Gut-Brain Axis on Diabetic Cognition Impairment

PubMed Central

Xu, Youhua; Zhou, Hua; Zhu, Quan

2017-01-01

Progressive cognitive dysfunction is a central characteristic of diabetic encephalopathy (DE). With an aging population, the incidence of DE is rising and it has become a major threat that seriously affects public health. Studies within this decade have indicated the important role of risk factors such as oxidative stress and inflammation on the development of cognitive impairment. With the recognition of the two-way communication between gut and brain, recent investigation suggests that “microbiota-gut-brain axis” also plays a pivotal role in modulating both cognition function and endocrine stability. This review aims to systemically elucidate the underlying impact of diabetes on cognitive impairment. PMID:28496408

Modeling for waste management associated with environmental-impact abatement under uncertainty.

PubMed

Li, P; Li, Y P; Huang, G H; Zhang, J L

2015-04-01

Municipal solid waste (MSW) treatment can generate significant amounts of pollutants, and thus pose a risk on human health. Besides, in MSW management, various uncertainties exist in the related costs, impact factors, and objectives, which can affect the optimization processes and the decision schemes generated. In this study, a life cycle assessment-based interval-parameter programming (LCA-IPP) method is developed for MSW management associated with environmental-impact abatement under uncertainty. The LCA-IPP can effectively examine the environmental consequences based on a number of environmental impact categories (i.e., greenhouse gas equivalent, acid gas emissions, and respiratory inorganics), through analyzing each life cycle stage and/or major contributing process related to various MSW management activities. It can also tackle uncertainties existed in the related costs, impact factors, and objectives and expressed as interval numbers. Then, the LCA-IPP method is applied to MSW management for the City of Beijing, the capital of China, where energy consumptions and six environmental parameters [i.e., CO2, CO, CH4, NOX, SO2, inhalable particle (PM10)] are used as systematic tool to quantify environmental releases in entire life cycle stage of waste collection, transportation, treatment, and disposal of. Results associated with system cost, environmental impact, and the related policy implication are generated and analyzed. Results can help identify desired alternatives for managing MSW flows, which has advantages in providing compromised schemes under an integrated consideration of economic efficiency and environmental impact under uncertainty.

Receptor modelling and risk assessment of volatile organic compounds measured at a regional background site in South Africa

NASA Astrophysics Data System (ADS)

Jaars, Kerneels; Vestenius, Mika; van Zyl, Pieter G.; Beukes, Johan P.; Hellén, Heidi; Vakkari, Ville; Venter, Marcell; Josipovic, Miroslav; Hakola, Hannele

2018-01-01

Volatile organic compounds (VOCs) can have significant impacts on climate and human health. Certain VOCs are proven to be carcinogenic and toxic, which can affect human health directly and indirectly. In order to develop climate change reduction strategies and to assess the impacts of VOCs on human health, it is crucial to determine the sources of VOCs, which can be emitted from biogenic and anthropogenic sources. The aim of this study was to perform source apportionment using positive matrix factorisation (PMF) analysis on VOC data collected at a regional background location affected by the major sources in the interior of South Africa, which include the western- and eastern Bushveld Igneous Complex, the Johannesburg-Pretoria metropolitan conurbation, the Vaal Triangle, the Mpumalanga Highveld and also a region of anti-cyclonic recirculation of air mass over the interior of South Africa. In addition, a risk assessment study was also performed in view of the major source regions affecting Welgegund in order to quantify the impacts of anthropogenic VOCs measured at Welgegund on human health. Measurements were conducted at the Welgegund measurement station located on a commercial farm approximately 100 km west of Johannesburg for a period of more than two years. PMF analysis revealed ten meaningful factor solutions, of which five factors were associated with biogenic emissions and five with anthropogenic sources. Three of the biogenic factors were characterised by a specific biogenic species, i.e. isoprene, limonene and 2-methyl-3-buten-2-ol (MBO), while the other two biogenic factors comprised mixtures of biogenic species with different tracer species. The temporal factor contribution for the isoprene, limonene and MBO factors correlated relatively well with the seasonal wet pattern. One anthropogenic factor was associated with emissions from a densely populated anthropogenic source region to the east of Welgegund with a large number of industrial activities, while another anthropogenic factor could be related to coal combustion. An anthropogenic factor was also identified that reflected the influence of solvents on atmospheric VOC concentrations, while two anthropogenic factors were determined that indicated the influence of farming activities in close proximity to Welgegund. A lifetime cancer risk- (LCR) and non-cancer hazard ratio (HR) assessment study conducted for VOCs measured at Welgegund in relation to three source regions indicated that the non-cancerous influence of VOCs measured in the source regions is significantly lower compared to the cancerous influence of these species on human health, which raises concern. However, LCR values were within an acceptable range. Factor analysis performed in this paper also identified sources that could be targeted to minimise VOC-related LCRs and HRs e.g. benzene-related cancers can be reduced by targeting incomplete combustion sources and coal combustion.

Galaxy mergers moulding the circum-galactic medium - I. The impact of a major merger

NASA Astrophysics Data System (ADS)

Hani, Maan H.; Sparre, Martin; Ellison, Sara L.; Torrey, Paul; Vogelsberger, Mark

2018-03-01

Galaxies are surrounded by sizeable gas reservoirs which host a significant amount of metals: the circum-galactic medium (CGM). The CGM acts as a mediator between the galaxy and the extragalactic medium. However, our understanding of how galaxy mergers, a major evolutionary transformation, impact the CGM remains deficient. We present a theoretical study of the effect of galaxy mergers on the CGM. We use hydrodynamical cosmological zoom-in simulations of a major merger selected from the Illustris project such that the z = 0 descendant has a halo mass and stellar mass comparable to the Milky Way. To study the CGM we then re-simulated this system at a 40 times better mass resolution, and included detailed post-processing ionization modelling. Our work demonstrates the effect the merger has on the characteristic size of the CGM, its metallicity, and the predicted covering fraction of various commonly observed gas-phase species, such as H I, C IV, and O VI. We show that merger-induced outflows can increase the CGM metallicity by 0.2-0.3 dex within 0.5 Gyr post-merger. These effects last up to 6 Gyr post-merger. While the merger increases the total metal covering fractions by factors of 2-3, the covering fractions of commonly observed UV ions decrease due to the hard ionizing radiation from the active galactic nucleus, which we model explicitly. Our study of the single simulated major merger presented in this work demonstrates the significant impact that a galaxy interaction can have on the size, metallicity, and observed column densities of the CGM.

Factors Related to Cigarette Smoking Initiation and Use among College Students

PubMed Central

2005-01-01

The purpose of this cross-sectional study was to examine the impact of personality factors (neuroticism, extraversion, openness, agreeableness, and conscientiousness), cognitive factors (sense of coherence and self-efficacy), coping resources (family and friend social support) and demographic factors (gender and ethnicity) on cigarette smoking behaviors (initiation, frequency, and amount of cigarette smoking) among college students. A total of 161 U.S. college students, aged 18–26, who enrolled in an introductory psychology course completed self-report questionnaires. The majority of the students had tried smoking (55%); among those who had tried, 42% were current smokers. The majority (77%) who had smoked a whole cigarette did so at age 16 years or younger. Students who reported lower levels of conscientiousness and self-efficacy had a greater likelihood to had tried cigarette smoking. Also, students who had lower levels of self-efficacy reported smoking more frequently and greater quantities of cigarettes than students with higher levels of self-efficacy. Self-efficacy was the most significant predictor of smoking behaviors. Health promotion programs focused on self-efficacy may be an effective tool for reducing the initiation, frequency, and amount of cigarette smoking among college students. PMID:19570288

Cultural factors influencing Japanese nurses' assertive communication. Part 1: Collectivism.

PubMed

Omura, Mieko; Stone, Teresa E; Levett-Jones, Tracy

2018-02-06

Culture influences the way health-care professionals communicate with each other and their ability to relate to colleagues in an assertive manner. Cultural barriers can also make it difficult for nurses to speak up even when they have concerns about patient safety. An understanding of the potential impact of cultural factors is therefore needed when developing assertiveness communication training programs. This paper presents the findings from a study that explored Japanese nurses' perceptions of how culture and values impact assertive communication in health care. Semistructured interviews with 23 registered nurses were undertaken, and data were analyzed using directed content analysis. Two major themes were identified: collectivism and hierarchy/power. In the present study, we discuss the cultural values related to collectivism that included four categories of "wa" (harmony), "uchi to soto" (inside and outside), implicit communication/ambiguity, and "nemawashi" (groundwork). The findings highlight the impact of culture on nurses' assertive communication behaviors and can be used to inform the design of culturally-appropriate assertiveness communication training programs for Japanese nurses working both within their own country or internationally. © 2018 John Wiley & Sons Australia, Ltd.

Rangewide determinants of population performance in Prunus lusitanica: Lessons for the contemporary conservation of a Tertiary relict tree

NASA Astrophysics Data System (ADS)

Pardo, Adara; Cáceres, Yonatan; Pulido, Fernando

2018-01-01

Relict species are an extremely important part of biodiversity and as such studies on the factors that allow their current persistence are required. The aim of this study was to assess the determinants of the distribution and range-wide population performance of the Tertiary relict tree Prunus lusitanica L. This threatened species is confined to Iberia, Northern Morocco and Macaronesia with a fragmented and scattered distribution. Using ecological niche modelling, we calculated the level of range filling across the range and tested its relationship with human impact. We then assessed the relative importance of climatic suitability as obtained through niche modelling, topographic factors and contemporary human impact on range-wide population performance. Results showed that the species occupies only 2.4% of the overall area predicted to be climatically suitable for its presence and the level of range filling varied across regions. A weak negative relationship among range filling and human impact was found. Overall climatic suitability was the strongest predictor of population performance. However, it showed high variability across regions: the effect was positive in Iberia whereas negative but not significant in Macaronesia and Morocco. Human impact showed a significant negative effect and finally topographic factors such as altitude had a minor negative effect. Our results highlight that both climate and human impact play a major role in the current limited range filling and performance of the species. Management plans to minimize anthropogenic disturbances together with reforestation measures are urgently needed in order to conserve this unique species.

Environmental impact associated with activated carbon preparation from olive-waste cake via life cycle assessment.

PubMed

Hjaila, K; Baccar, R; Sarrà, M; Gasol, C M; Blánquez, P

2013-11-30

The life cycle assessment (LCA) environmental tool was implemented to quantify the potential environmental impacts associated with the activated carbon (AC) production process from olive-waste cakes in Tunisia. On the basis of laboratory investigations for AC preparation, a flowchart was developed and the environmental impacts were determined. The LCA functional unit chosen was the production of 1 kg of AC from by-product olive-waste cakes. The results showed that impregnation using H3PO4 presented the highest environmental impacts for the majority of the indicators tested: acidification potential (62%), eutrophication (96%), ozone depletion potential (44%), human toxicity (64%), fresh water aquatic ecotoxicity (90%) and terrestrial ecotoxicity (92%). One of the highest impacts was found to be the global warming potential (11.096 kg CO2 eq/kg AC), which was equally weighted between the steps involving impregnation, pyrolysis, and drying the washed AC. The cumulative energy demand of the AC production process from the by-product olive-waste cakes was 167.63 MJ contributed by impregnation, pyrolysis, and drying the washed AC steps. The use of phosphoric acid and electricity in the AC production were the main factors responsible for the majority of the impacts. If certain modifications are incorporated into the AC production, such as implementing synthesis gas recovery and reusing it as an energy source and recovery of phosphoric acid after AC washing, additional savings could be realized, and environmental impacts could be minimized. Copyright © 2013 Elsevier Ltd. All rights reserved.

Multicenter retrospective analysis of cardiovascular risk factors affecting long-term outcome of de novo cardiac transplant recipients.

PubMed

Kobashigawa, Jon A; Starling, Randall C; Mehra, Mandeep R; Kormos, Robert L; Bhat, Geetha; Barr, Mark L; Sigouin, Chris S; Kolesar, June; Fitzsimmons, William

2006-09-01

Previous risk factor studies in cardiac transplant patients have analyzed pre-transplant risk factors as they relate to outcomes. This study is the first in-depth multicenter assessment of ongoing post-transplant risk factors in heart transplant patients and their impact on 5-year outcomes. We reviewed 280 heart transplant patients who survived > 1 year for the impact of post-transplant risk factors (hyperlipidemia, hypertension, diabetes, body mass index [BMI] and renal dysfunction: 8 to 18 possible measurements over 5 years) on outcomes, including death, cardiac allograft vasculopathy (CAV) and non-fatal major adverse cardiac events (NF-MACE). Upon multivariate Cox regression analysis, significant findings were high total-cholesterol for NF-MACE (relative risk [RR] = 4.34, confidence interval [CI] 1.35 to 13.98, p = 0.01), presence of diabetes for NF-MACE (RR = 3.96, CI 1.24 to 12.65, p = 0.02) and high serum creatinine for graft death (RR = 1.59, CI 1.35 to 1.87, p < 0.001). No covariates were found to be significant for CAV. Other significant risk factors by univariate Cox regression models with time-dependent covariates included BMI > or = 33 for graft death. Post-transplant risk factors of hypercholesterolemia and diabetes are associated with NF-MACE, whereas high serum creatinine and BMI > or = 33 are associated with graft death. Risk factor modification, including direct therapy to minimize risk factors, should be considered.

Comparative study on neutronics characteristics of a 1500 MWe metal fuel sodium-cooled fast reactor

DOE PAGES

Ohgama, Kazuya; Aliberti, Gerardo; Stauff, Nicolas E.; ...

2017-02-28

Under the cooperative effort of the Civil Nuclear Energy R&D Working Group within the framework of the U.S.-Japan bilateral, Argonne National Laboratory (ANL) and Japan Atomic Energy Agency (JAEA) have been performing benchmark study using Japan Sodium-cooled Fast Reactor (JSFR) design with metal fuel. In this benchmark study, core characteristic parameters at the beginning of cycle were evaluated by the best estimate deterministic and stochastic methodologies of ANL and JAEA. The results obtained by both institutions show a good agreement with less than 200 pcm of discrepancy on the neutron multiplication factor, and less than 3% of discrepancy on themore » sodium void reactivity, Doppler reactivity, and control rod worth. The results by the stochastic and deterministic approaches were compared in each party to investigate impacts of the deterministic approximation and to understand potential variations in the results due to different calculation methodologies employed. From the detailed analysis of methodologies, it was found that the good agreement in multiplication factor from the deterministic calculations comes from the cancellation of the differences on the methodology (0.4%) and nuclear data (0.6%). The different treatment in reflector cross section generation was estimated as the major cause of the discrepancy between the multiplication factors by the JAEA and ANL deterministic methodologies. Impacts of the nuclear data libraries were also investigated using a sensitivity analysis methodology. Furthermore, the differences on the inelastic scattering cross sections of U-238, ν values and fission cross sections of Pu-239 and µ-average of Na-23 are the major contributors to the difference on the multiplication factors.« less

Temporal dynamics and impact of climate factors on the incidence of zoonotic cutaneous leishmaniasis in central Tunisia.

PubMed

Toumi, Amine; Chlif, Sadok; Bettaieb, Jihene; Ben Alaya, Nissaf; Boukthir, Aicha; Ahmadi, Zaher E; Ben Salah, Afif

2012-01-01

Old world Zoonotic Cutaneous Leishmaniasis (ZCL) is a vector-borne human disease caused by Leishmania major, a unicellular eukaryotic parasite transmitted by pool blood-feeding sand flies mainly to wild rodents, such as Psammomys obesus. The human beings who share the rodent and sand fly habitats can be subverted as both sand fly blood resource. ZCL is endemic in the Middle East, Central Asia, Subsaharan and North Africa. Like other vector-borne diseases, the incidence of ZCL displayed by humans varies with environmental and climate factors. However, so far no study has addressed the temporal dynamics or the impact of climate factors on the ZCL risk. Seasonality during the same epidemiologic year and interval between ZCL epidemics ranging from 4 to 7 years were demonstrated. Models showed that ZCL incidence is raising i) by 1.8% (95% confidence intervals CI:0.0-3.6%) when there is 1 mm increase in the rainfall lagged by 12 to 14 months ii) by 5.0% (95% CI: 0.8-9.4%) when there is a 1% increase in humidity from July to September in the same epidemiologic year. Higher rainfall is expected to result in increased density of chenopods, a halophytic plant that constitutes the exclusive food of Psammomys obesus. Consequently, following a high density of Psammomys obesus, the pool of Leishmania major transmissible from the rodents to blood-feeding female sand flies could lead to a higher probability of transmission to humans over the next season. These findings provide the evidence that ZCL is highly influenced by climate factors that could affect both Psammomys obesus and the sand fly population densities.

Temporal Dynamics and Impact of Climate Factors on the Incidence of Zoonotic Cutaneous Leishmaniasis in Central Tunisia

PubMed Central

Toumi, Amine; Chlif, Sadok; Bettaieb, Jihene; Alaya, Nissaf Ben; Boukthir, Aicha; Ahmadi, Zaher E.; Salah, Afif Ben

2012-01-01

Background Old world Zoonotic Cutaneous Leishmaniasis (ZCL) is a vector-borne human disease caused by Leishmania major, a unicellular eukaryotic parasite transmitted by pool blood-feeding sand flies mainly to wild rodents, such as Psammomys obesus. The human beings who share the rodent and sand fly habitats can be subverted as both sand fly blood resource. ZCL is endemic in the Middle East, Central Asia, Subsaharan and North Africa. Like other vector-borne diseases, the incidence of ZCL displayed by humans varies with environmental and climate factors. However, so far no study has addressed the temporal dynamics or the impact of climate factors on the ZCL risk. Principal Findings Seasonality during the same epidemiologic year and interval between ZCL epidemics ranging from 4 to 7 years were demonstrated. Models showed that ZCL incidence is raising i) by 1.8% (95% confidence intervals CI:0.0–3.6%) when there is 1 mm increase in the rainfall lagged by 12 to 14 months ii) by 5.0% (95% CI: 0.8–9.4%) when there is a 1% increase in humidity from July to September in the same epidemiologic year. Conclusion/Significance Higher rainfall is expected to result in increased density of chenopods, a halophytic plant that constitutes the exclusive food of Psammomys obesus. Consequently, following a high density of Psammomys obesus, the pool of Leishmania major transmissible from the rodents to blood-feeding female sand flies could lead to a higher probability of transmission to humans over the next season. These findings provide the evidence that ZCL is highly influenced by climate factors that could affect both Psammomys obesus and the sand fly population densities. PMID:22563513

Comparative study on neutronics characteristics of a 1500 MWe metal fuel sodium-cooled fast reactor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ohgama, Kazuya; Aliberti, Gerardo; Stauff, Nicolas E.

Under the cooperative effort of the Civil Nuclear Energy R&D Working Group within the framework of the U.S.-Japan bilateral, Argonne National Laboratory (ANL) and Japan Atomic Energy Agency (JAEA) have been performing benchmark study using Japan Sodium-cooled Fast Reactor (JSFR) design with metal fuel. In this benchmark study, core characteristic parameters at the beginning of cycle were evaluated by the best estimate deterministic and stochastic methodologies of ANL and JAEA. The results obtained by both institutions show a good agreement with less than 200 pcm of discrepancy on the neutron multiplication factor, and less than 3% of discrepancy on themore » sodium void reactivity, Doppler reactivity, and control rod worth. The results by the stochastic and deterministic approaches were compared in each party to investigate impacts of the deterministic approximation and to understand potential variations in the results due to different calculation methodologies employed. From the detailed analysis of methodologies, it was found that the good agreement in multiplication factor from the deterministic calculations comes from the cancellation of the differences on the methodology (0.4%) and nuclear data (0.6%). The different treatment in reflector cross section generation was estimated as the major cause of the discrepancy between the multiplication factors by the JAEA and ANL deterministic methodologies. Impacts of the nuclear data libraries were also investigated using a sensitivity analysis methodology. Furthermore, the differences on the inelastic scattering cross sections of U-238, ν values and fission cross sections of Pu-239 and µ-average of Na-23 are the major contributors to the difference on the multiplication factors.« less

Impact of major depressive disorder, distinct subtypes, and symptom severity on lifestyle in the BiDirect Study.

PubMed

Rahe, Corinna; Khil, Laura; Wellmann, Jürgen; Baune, Bernhard T; Arolt, Volker; Berger, Klaus

2016-11-30

The aim of this study was to examine associations of major depressive disorder (MDD), its distinct subtypes, and symptom severity with the individual lifestyle factors smoking, diet quality, physical activity, and body mass index as well as with a combined lifestyle index measuring the co-occurrence of these lifestyle factors. A sample of 823 patients with MDD and 597 non-depressed controls was examined. The psychiatric assessment was based on a clinical interview including the Mini International Neuropsychiatric Interview and the Hamilton Depression Rating Scale. Each lifestyle factor was scored as either healthy or unhealthy, and the number of unhealthy lifestyle factors was added up in a combined lifestyle index. Cross-sectional analyses were performed using alternating logistic regression and ordinal logistic regression, adjusted for socio-demographic characteristics. After adjustment, MDD was significantly associated with smoking, low physical activity, and overweight. Likewise, MDD was significantly related to the overall lifestyle index. When stratifying for subtypes, all subtypes showed higher odds for an overall unhealthier lifestyle than controls, but the associations with the individual lifestyle factors were partly different. Symptom severity was associated with the lifestyle index in a dose-response manner. In conclusion, patients with MDD represent an important target group for lifestyle interventions. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

An Analysis of the Impact of RFID Technology on Inventory Systems

NASA Astrophysics Data System (ADS)

Rekik, Yacine

Nowadays, most enterprises undertake large investments in order to implement information systems that support decision making for managing inventories. Nevertheless, if data collected from the physical processes used to feed these systems are not correct, there will be severe impacts on business performance. Inventory inaccuracy occurs when the inventory level in the Information System is not in agreement with the physically available inventory. In this chapter, we first describe the major factors generating inventory inaccuracy. Then, we provide situations permitting to manage an inventory system subject to errors. We provide a framework to model the inventory inaccuracy issue and focus on the impact of advanced identification systems, such as that provided by RFID technology, in improving the performance of a supply chain subject to inventory inaccuracies.

Effects of sea level rise, land subsidence, bathymetric change and typhoon tracks on storm flooding in the coastal areas of Shanghai.

PubMed

Wang, Jun; Yi, Si; Li, Mengya; Wang, Lei; Song, Chengcheng

2018-04-15

We compared the effects of three key environmental factors of coastal flooding: sea level rise (SLR), land subsidence (LS) and bathymetric change (BC) in the coastal areas of Shanghai. We use the hydrological simulation model MIKE 21 to simulate flood magnitudes under multiple scenarios created from combinations of the key environmental factors projected to year 2030 and 2050. Historical typhoons (TC9711, TC8114, TC0012, TC0205 and TC1109), which caused extremely high surges and considerable losses, were selected as reference tracks to generate potential typhoon events that would make landfalls in Shanghai (SHLD), in the north of Zhejiang (ZNLD) and moving northwards in the offshore area of Shanghai (MNS) under those scenarios. The model results provided assessment of impact of single and compound effects of the three factors (SLR, LS and BC) on coastal flooding in Shanghai for the next few decades. Model simulation showed that by the year 2030, the magnitude of storm flooding will increase due to the environmental changes defined by SLR, LS, and BC. Particularly, the compound scenario of the three factors will generate coastal floods that are 3.1, 2.7, and 1.9 times greater than the single factor change scenarios by, respectively, SLR, LS, and BC. Even more drastically, in 2050, the compound impact of the three factors would be 8.5, 7.5, and 23.4 times of the single factors. It indicates that the impact of environmental changes is not simple addition of the effects from individual factors, but rather multiple times greater of that when the projection time is longer. We also found for short-term scenarios, the bathymetry change is the most important factor for the changes in coastal flooding; and for long-term scenarios, sea level rise and land subsidence are the major factors that coastal flood prevention and management should address. Copyright © 2017 Elsevier B.V. All rights reserved.

Can plant-natural enemy communication withstand disruption by biotic and abiotic factors?

PubMed

Clavijo McCormick, Andrea

2016-12-01

The attraction of natural enemies towards herbivore-induced plant volatiles is a well-documented phenomenon. However, the majority of published studies are carried under optimal water and nutrient regimes and with just one herbivore. But what happens when additional levels of ecological complexity are added? Does the presence of a second herbivore, microorganisms, and abiotic stress interfere with plant-natural enemy communication? or is communication stable enough to withstand disruption by additional biotic and abiotic factors?Investigating the effects of these additional levels of ecological complexity is key to understanding the stability of tritrophic interactions in natural ecosystems and may aid to forecast the impact of environmental disturbances on these, especially in climate change scenarios, which are often associated with modifications in plant and arthropod species distribution and increased levels of abiotic stress.This review explores the literature on natural enemy attraction to herbivore-induced volatiles when, besides herbivory, plants are challenged by additional biotic and abiotic factors.The aim of this review was to establish the impact of different biotic and abiotic factors on plant-natural enemy communication and to highlight critical aspects to guide future research efforts.

Ecological influences of sexuality on early adolescent African American females.

PubMed

Aronowitz, Teri; Rennells, Rachel E; Todd, Erin

2006-01-01

African Americans make up the greater proportion of AIDS cases in adolescent girls but little is understood about the development of sexual risk behaviors during the early adolescent years. This article will explore ecological factors influencing adolescent sexual risk behaviors. In the focus groups, which were conducted using 28 African American mothers and their early adolescent daughters, 2 major themes emerged: exposure and support systems. Mothers described the impact community had on their daughters and how monitoring and support systems worked together to control exposure. The girls detailed the different ways they were impacted by the community. Attitudes the girls adopted from their exposures resulted in risk-taking behaviors or a determination to positively impact the community. Community was shown to be the context of the acquisition of sexual knowledge and attitudes. These findings support the development of interventions to address the impact of community on the participation of sexual risk behaviors.

Epidemiology of Major Non-communicable Diseases in Ethiopia: A Systematic Review

PubMed Central

Mariam, Damen Haile; Ali, Ahmed; Araya, Tekebash

2014-01-01

Impact of non-communicable diseases is not well-documented in Ethiopia. We aimed to document the prevalence and mortality associated with four major non-communicable diseases in Ethiopia: cardiovascular disease, cancer, diabetes, and chronic obstructive pulmonary disease. Associated risk factors: hypertension, tobacco-use, harmful use of alcohol, overweight/obesity, and khat-chewing were also studied. Systematic review of peer-reviewed and grey literature between 1960 and 2011 was done using PubMed search engines and local libraries to identify prevalence studies on the four diseases. In total, 32 studies were found, and half of these studies were from Addis Ababa. Two hospital-based studies reviewed the prevalence of cardiovascular disease and found a prevalence of 7.2% and 24%; a hospital-based study reviewed cancer prevalence and found a prevalence of 0.3%; two hospital-based studies reviewed diabetes prevalence and found a prevalence of 0.5% and 1.2%; and two hospital-based studies reviewed prevalence of asthma and found a prevalence of 1% and 3.5%. Few community-based studies were done on the prevalence of diabetes and chronic pulmonary obstructive disease among the population. Several studies reviewed the impact of these diseases on mortality: cardiovascular disease accounts for 24% of deaths in Addis Ababa, cancer causes 10% of deaths in the urban settings and 2% deaths in rural setting, and diabetes causes 5% and chronic obstructive pulmonary disease causes 3% of deaths. Several studies reviewed the impact of these diseases on hospital admissions: cardiovascular disease accounts for 3%-12.6% and found to have increased between 1970s and 2000s; cancer accounts for 1.1%-2.8%, diabetes accounts for 0.5%-1.2%, and chronic obstructive diseases account for 2.7%-4.3% of morbidity. Overall, the major non-communicable diseases and related risk factors are highly prevalent, and evidence-based interventions should be designed. PMID:24847587

Climate change impacts on water availability: developing regional scenarios for agriculture of the Former Soviet Union countries of Central Asia

NASA Astrophysics Data System (ADS)

Kirilenko, A.; Dronin, N.

2010-12-01

Water is the major factor, limiting agriculture of the five Former Soviet Union (FSU) of Central Asia. Elevated topography prevents moist and warm air from the Atlantic and Indian Oceans from entering the region.With exception of Kazakhstan, agriculture is generally restricted to oases and irrigated lands along the major rivers and canals. Availability of water for irrigation is the major factor constraining agriculture in the region, and conflicts over water are not infrequent. The current water crisis in the region is largely due to human activity; however the region is also strongly impacted by the climate. In multiple locations, planned and autonomous adaptations to climate change have already resulted in changes in agriculture, such as a dramatic increase in irrigation, or shift in crops towards the ones better suited for warmer and dryer climate; however, it is hard to differentiate between the effects of overall management improvement and the avoidance of climate-related losses. Climate change will contribute to water problems, escalating irrigation demand during the drought period, and increasing water loss with evaporation. The future of the countries of the Aral Sea basin then depends on both the regional scenario of water management policy and a global scenario of climate change, and is integrated with global socioeconomic scenarios. We formulate a set of regional policy scenarios (“Business as Usual”, “Falling Behind” and “Closing the Gap”) and demonstrate how each of them corresponds to IPCC SRES scenarios, the latter used as an input to the General Circulation Models (GCMs). Then we discuss the relative effectiveness of the introduced scenarios for mitigating water problems in the region, taking into account the adaptation through changing water demand for agriculture. Finally, we introduce the results of multimodel analysis of GCM climate projections, especially in relation to the change in precipitation and frequency of droughts, and discuss the impact of climate change on future development of the region.

Microbial Etiology of Pneumonia: Epidemiology, Diagnosis and Resistance Patterns.

PubMed

Cilloniz, Catia; Martin-Loeches, Ignacio; Garcia-Vidal, Carolina; San Jose, Alicia; Torres, Antoni

2016-12-16

Globally, pneumonia is a serious public health concern and a major cause of mortality and morbidity. Despite advances in antimicrobial therapies, microbiological diagnostic tests and prevention measures, pneumonia remains the main cause of death from infectious disease in the world. An important reason for the increased global mortality is the impact of pneumonia on chronic diseases, along with the increasing age of the population and the virulence factors of the causative microorganism. The increasing number of multidrug-resistant bacteria, difficult-to-treat microorganisms, and the emergence of new pathogens are a major problem for clinicians when deciding antimicrobial therapy. A key factor for managing and effectively guiding appropriate antimicrobial therapy is an understanding of the role of the different causative microorganisms in the etiology of pneumonia, since it has been shown that the adequacy of initial antimicrobial therapy is a key factor for prognosis in pneumonia. Furthermore, broad-spectrum antibiotic therapies are sometimes given until microbiological results are available and de-escalation cannot be performed quickly. This review provides an overview of microbial etiology, resistance patterns, epidemiology and microbial diagnosis of pneumonia.

Falls and Fractures: A systematic approach to screening and prevention.

PubMed

Ambrose, Anne Felicia; Cruz, Lisanne; Paul, Geet

2015-09-01

Falls are one of the major causes of mortality and morbidity in older adults. Every year, an estimated 30-40% of patients over the age of 65 will fall at least once. Falls lead to moderate to severe injuries, fear of falling, loss of independence and death in a third of those patients. Falls account for 87 % of all fractures in the elderly. These fractures are almost always due to low impact injuries in osteoporotic bones. Several organizations have recommended screening older patients to identify those with a high risk of falling and, or fractures. The present review provides a brief summary and update of the relevant literature, summarizing screening tools and interventions to prevent falls and fractures. The major risk factors identified are impaired balance and gait, polypharmacy, and history of previous falls. Other risk factors include advancing age, female gender, visual impairments, cognitive decline especially attention and executive dysfunction, and environmental factors. Recommendations for the clinician to screen and prevent falls in older patients are also summarized. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Multivariate statistical analysis to characterize/discriminate between anthropogenic and geogenic trace elements occurrence in the Campania Plain, Southern Italy.

PubMed

Busico, Gianluigi; Cuoco, Emilio; Kazakis, Nerantzis; Colombani, Nicolò; Mastrocicco, Micòl; Tedesco, Dario; Voudouris, Konstantinos

2018-03-01

Shallow aquifers are the most accessible reservoirs of potable groundwater; nevertheless, they are also prone to various sources of pollution and it is usually difficult to distinguish between human and natural sources at the watershed scale. The area chosen for this study (the Campania Plain) is characterized by high spatial heterogeneities both in geochemical features and in hydraulic properties. Groundwater mineralization is driven by many processes such as, geothermal activity, weathering of volcanic products and intense human activities. In such a landscape, multivariate statistical analysis has been used to differentiate among the main hydrochemical processes occurring in the area, using three different approaches of factor analysis: (i) major elements, (ii) trace elements, (iii) both major and trace elements. The elaboration of the factor analysis approaches has revealed seven distinct hydrogeochemical processes: i) Salinization (Cl - , Na + ); ii) Carbonate rocks dissolution; iii) Anthropogenic inputs (NO 3 - , SO 4 2- , U, V); iv) Reducing conditions (Fe 2+ , Mn 2+ ); v) Heavy metals contamination (Cr and Ni); vi) Geothermal fluids influence (Li + ); and vii) Volcanic products contribution (As, Rb). Results from this study highlight the need to separately apply factor analysis when a large data set of trace elements is available. In fact, the impact of geothermal fluids in the shallow aquifer was identified from the application of the factor analysis using only trace elements. This study also reveals that the factor analysis of major and trace elements can differentiate between anthropogenic and geogenic sources of pollution in intensively exploited aquifers. Copyright © 2017 Elsevier Ltd. All rights reserved.

Paternal levels of DNA damage in spermatozoa and maternal parity influence offspring mortality in an endangered ungulate.

PubMed

Ruiz-López, María José; Espeso, Gerardo; Evenson, Donald P; Roldan, Eduardo R S; Gomendio, Montserrat

2010-08-22

Understanding which factors influence offspring mortality rates is a major challenge since it influences population dynamics and may constrain the chances of recovery among endangered species. Most studies have focused on the effects of maternal and environmental factors, but little is known about paternal factors. Among most polygynous mammals, males only contribute the haploid genome to their offspring, but the possibility that sperm DNA integrity may influence offspring survival has not been explored. We examined several maternal, paternal and individual factors that may influence offspring survival in an endangered species (Gazella cuvieri). Levels of sperm DNA damage had the largest impact upon offspring mortality rates, followed by maternal parity. In addition, there was a significant interaction between these two variables, so that offspring born to primiparous mothers were more likely to die if their father had high levels of sperm DNA damage, but this was not the case among multiparous mothers. Thus, multiparous mothers seem to protect their offspring from the deleterious effects of sperm DNA damage. Since levels of sperm DNA damage seem to be higher among endangered species, more attention should be paid to the impact of this largely ignored factor among the viability of endangered species.

The Impact of Operative Approach on Postoperative Complications Following Colectomy for Colon Caner.

PubMed

Mungo, Benedetto; Papageorge, Christina M; Stem, Miloslawa; Molena, Daniela; Lidor, Anne O

2017-08-01

Colectomy is one of the most common major abdominal procedures performed in the USA. A better understanding of risk factors and the effect of operative approach on adverse postoperative outcomes may significantly improve quality of care. Adult patients with a primary diagnosis of colon cancer undergoing colectomy were selected from the National Surgical Quality Improvement Program 2013-2015 targeted colectomy database. Patients were stratified into five groups based on specific operative approach. Univariate and multivariate analyses were used to compare the five groups and identify risk factors for 30-day anastomotic leak, readmission, and mortality. In total, 25,097 patients were included in the study, with a 3.32% anastomotic leak rate, 1.20% mortality rate, and 9.57% readmission rate. After adjusting for other factors, open surgery and conversion to open significantly increased the odds for leak, mortality, and readmission compared to laparoscopy. Additionally, smoking and chemotherapy increased the risk for leak and readmission, while total resection was associated with increased mortality and leak. Operative approach and several other potentially modifiable perioperative factors have a significant impact on risk for adverse postoperative outcomes following colectomy. To improve quality of care for these patients, efforts should be made to identify and minimize the influence of such risk factors.

A Multidisciplinary Research Agenda for Understanding Vaccine-Related Decisions

PubMed Central

Larson, Heidi; Leask, Julie; Aggett, Sian; Sevdalis, Nick; Thomson, Angus

2013-01-01

There is increasingly broad global recognition of the need to better understand determinants of vaccine acceptance. Fifteen social science, communication, health, and medical professionals (the “Motors of Trust in Vaccination” (MOTIV) think tank) explored factors relating to vaccination decision-making as a step to building a multidisciplinary research agenda. One hundred and forty seven factors impacting decisions made by consumers, professionals, and policy makers on vaccine acceptance, delay, or refusal were identified and grouped into three major categories: cognition and decision-making; groups and social norms; and communication and engagement. These factors should help frame a multidisciplinary research agenda to build an evidence base on the determinants of vaccine acceptance to inform the development of interventions and vaccination policies. PMID:26344114

The asymmetric impact of natural disasters on China's bilateral trade

NASA Astrophysics Data System (ADS)

Meng, Y.; Shi, P.; Yang, S.; Jeager, C. C.

2015-03-01

Globalization and technological revolutions are making the world more interconnected. International trade is one of the major approaches linking the world. Since the 2011 Tohoku earthquake and tsunami in Japan shocked the global supply chain, more attention has been paid to the global impact of large-scale disasters. China is the second largest trader in the world and faces the most frequent natural disasters. Therefore, this study proposes a gravity model for China's bilateral trade tailored to national circumstances, and estimates the impact of natural disasters in China and trading partner countries on Chinese imports and exports. We analyzed Chinese and trading partner statistical data from 1980 to 2012. Study results show that: (1) China's natural disasters have a positive impact on imports, but have no significant impact on exports, (2) trading partner countries' natural disasters reduce Chinese imports and exports, (3) both development level and land area of the partners are important in determining the intensity of natural disaster impacts on China's bilateral trade. The above findings suggest that the impact of natural disasters on trade is asymmetric and significantly affected by other factors, which demand further study.

Impact of snow deposition on major and trace element concentrations and elementary fluxes in surface waters of the Western Siberian Lowland across a 1700 km latitudinal gradient

NASA Astrophysics Data System (ADS)

Shevchenko, Vladimir P.; Pokrovsky, Oleg S.; Vorobyev, Sergey N.; Krickov, Ivan V.; Manasypov, Rinat M.; Politova, Nadezhda V.; Kopysov, Sergey G.; Dara, Olga M.; Auda, Yves; Shirokova, Liudmila S.; Kolesnichenko, Larisa G.; Zemtsov, Valery A.; Kirpotin, Sergey N.

2017-11-01

In order to better understand the chemical composition of snow and its impact on surface water hydrochemistry in the poorly studied Western Siberia Lowland (WSL), the surface layer of snow was sampled in February 2014 across a 1700 km latitudinal gradient (ca. 56.5 to 68° N). We aimed at assessing the latitudinal effect on both dissolved and particulate forms of elements in snow and quantifying the impact of atmospheric input to element storage and export fluxes in inland waters of the WSL. The concentration of dissolved+colloidal (< 0.45 µm) Fe, Co, Cu, As and La increased by a factor of 2 to 5 north of 63° N compared to southern regions. The pH and dissolved Ca, Mg, Sr, Mo and U in snow water increased with the rise in concentrations of particulate fraction (PF). Principal component analyses of major and trace element concentrations in both dissolved and particulate fractions revealed two factors not linked to the latitude. A hierarchical cluster analysis yielded several groups of elements that originated from alumino-silicate mineral matrix, carbonate minerals and marine aerosols or belonging to volatile atmospheric heavy metals, labile elements from weatherable minerals and nutrients. The main sources of mineral components in PF are desert and semi-desert regions of central Asia. The snow water concentrations of DIC, Cl, SO4, Mg, Ca, Cr, Co, Ni, Cu, Mo, Cd, Sb, Cs, W, Pb and U exceeded or were comparable with springtime concentrations in thermokarst lakes of the permafrost-affected WSL zone. The springtime river fluxes of DIC, Cl, SO4, Na, Mg, Ca, Rb, Cs, metals (Cr, Co, Ni, Cu, Zn, Cd, Pb), metalloids (As, Sb), Mo and U in the discontinuous to continuous permafrost zone (64-68° N) can be explained solely by melting of accumulated snow. The impact of snow deposition on riverine fluxes of elements strongly increased northward, in discontinuous and continuous permafrost zones of frozen peat bogs. This was consistent with the decrease in the impact of rock lithology on river chemical composition in the permafrost zone of the WSL, relative to the permafrost-free regions. Therefore, the present study demonstrates significant and previously underestimated atmospheric input of many major and trace elements to their riverine fluxes during spring floods. A broader impact of this result is that current estimations of river water fluxes response to climate warming in high latitudes may be unwarranted without detailed analysis of winter precipitation.

Europe. An analysis of changes in the consumption of alcoholic beverages: the interaction among consumption, related harms, contextual factors and alcoholic beverage control policies.

PubMed

Allamani, Allaman; Pepe, Pasquale; Baccini, Michela; Massini, Giulia; Voller, Fabio

2014-10-01

This AMPHORA study's aim was to investigate selected factors potentially affecting changes in consumption of alcoholic beverages in 12 European countries during the 1960s-2008 (an average increase in beer, decreases in wine and spirits, total alcohol drinking decrease). Both time series and artificial neural networks-based analyses were used. Results indicated that selected socio-demographic and economic factors showed an overall major impact on consumption changes; particularly urbanization, increased income, and older mothers' age at their childbirths were significantly associated with consumption increase or decrease, depending on the country. Alcoholic beverage control policies showed an overall minor impact on consumption changes: among them, permissive availability measures were significantly associated with consumption increases, while drinking and driving limits and availability restrictions were correlated with consumption decreases, and alcohol taxation and prices of the alcoholic beverages were not significantly correlated with consumption. Population ageing, older mother's age at childbirths, increased income and increases in female employment, as well as drink driving limitations were associated with the decrease of transport mortality. Study's limitations are noted.

Impact of the global economic crisis on metal levels in particulate matter (PM) at an urban area in the Cantabria Region (Northern Spain).

PubMed

Arruti, A; Fernández-Olmo, I; Irabien, A

2011-05-01

Air pollution by particulate matter is well linked with anthropogenic activities; the global economic crisis that broke out in the last year may be a proper indicator of this close relationship. Some economic indicators show the regional effects of the crisis on the Cantabria Region. The present work aims to evaluate the impact of the economic crisis on PM10 levels and composition at the major city of the region, Santander. Some metals linked to anthropogenic activities were measured at Santander and studied by Positive Matrix Factorization; this statistical analysis allowed to identify three main factors: urban background, industrial and molybdenum-related factor. The main results show that the temporal trend of the levels of the industrial tracers found in the present study are well agree with the evolution of the studied economic indicators; nevertheless, the urban background tracers and PM10 concentration levels are not well correlated with the studied economic indicators. Copyright © 2011 Elsevier Ltd. All rights reserved.

Vulnerability Factors and Effectiveness of Disaster Mitigation Measures in the Bangladesh Coast

NASA Astrophysics Data System (ADS)

Hossain, Md. Nazir; Paul, Shitangsu Kumar

2018-01-01

The major objective of this paper is to identify the vulnerability factors and examine the effectiveness of disaster mitigation measures undertaken by individuals, government and non-government organisations to mitigate the impacts of cyclones in the Bangladesh coast experiencing from Cyclone Aila. The primary data were collected from two villages of southwestern coastal areas of Bangladesh using questionnaire survey and interviews of the key informants. The data were analysed using the descriptive and inferential statistics. This paper reveals that the disaster management measures have a significant role to lessen the impacts of the cyclonic event, especially in pre-disaster preparedness, cyclone warning message dissemination, evacuation and post-disaster rehabilitation. The households, who have access to shelter, find weather forecast regularly and adopted pre-disaster awareness measures are relatively less susceptible to hazard's impacts. The disaster management measures undertaken by individuals and GOs and NGOs help coastal people to save their lives and property from the negative impacts of cyclones. The analysis shows that the NGOs' role is more effective and efficient than the GOs in cyclone disaster management. This paper identifies distance to shelter, participation in disaster training, efficient warning, etc. as the influential factors of vulnerability cyclones. The analysis finds the households as less affected who have adopted disaster preparedness measures. However, this paper concludes that the effective and proper disaster management and mitigation measures are very crucial to shield the lives and properties of the Bangladeshi coastal people.

Vulnerability Factors and Effectiveness of Disaster Mitigation Measures in the Bangladesh Coast

NASA Astrophysics Data System (ADS)

Hossain, Md. Nazir; Paul, Shitangsu Kumar

2018-05-01

The major objective of this paper is to identify the vulnerability factors and examine the effectiveness of disaster mitigation measures undertaken by individuals, government and non-government organisations to mitigate the impacts of cyclones in the Bangladesh coast experiencing from Cyclone Aila. The primary data were collected from two villages of southwestern coastal areas of Bangladesh using questionnaire survey and interviews of the key informants. The data were analysed using the descriptive and inferential statistics. This paper reveals that the disaster management measures have a significant role to lessen the impacts of the cyclonic event, especially in pre-disaster preparedness, cyclone warning message dissemination, evacuation and post-disaster rehabilitation. The households, who have access to shelter, find weather forecast regularly and adopted pre-disaster awareness measures are relatively less susceptible to hazard's impacts. The disaster management measures undertaken by individuals and GOs and NGOs help coastal people to save their lives and property from the negative impacts of cyclones. The analysis shows that the NGOs' role is more effective and efficient than the GOs in cyclone disaster management. This paper identifies distance to shelter, participation in disaster training, efficient warning, etc. as the influential factors of vulnerability cyclones. The analysis finds the households as less affected who have adopted disaster preparedness measures. However, this paper concludes that the effective and proper disaster management and mitigation measures are very crucial to shield the lives and properties of the Bangladeshi coastal people.

The Impact of Visibility on Teamwork, Collaborative Communication, and Security in Emergency Departments: An Exploratory Study.

PubMed

Gharaveis, Arsalan; Hamilton, D Kirk; Pati, Debajyoti; Shepley, Mardelle

2017-01-01

The aim of this study was to examine the influence of visibility on teamwork, collaborative communication, and security issues in emergency departments (EDs). This research explored whether with high visibility in EDs, teamwork and collaborative communication can be improved while the security issues will be reduced. Visibility has been regarded as a critical design consideration and can be directly and considerably impacted by ED's physical design. Teamwork is one of the major related operational outcomes of visibility and involves nurses, support staff, and physicians. The collaborative communication in an ED is another important factor in the process of care delivery and affects efficiency and safety. Furthermore, security is a behavioral factor in ED designs, which includes all types of safety including staff safety, patient safety, and the safety of visitors and family members. This qualitative study investigated the impact of visibility on teamwork, collaborative communication, and security issues in the ED. One-on-one interviews and on-site observation sessions were conducted in a community hospital. Corresponding data analysis was implemented by using computer plan analysis, observation and interview content, and theme analyses. The findings of this exploratory study provided a framework to identify visibility as an influential factor in ED design. High levels of visibility impact productivity and efficiency of teamwork and communication and improve the chance of lowering security issues. The findings of this study also contribute to the general body of knowledge about the effect of physical design on teamwork, collaborative communication, and security.

Exploring the Impact of TeachME™ Lab Virtual Classroom Teaching Simulation on Early Childhood Education Majors' Self-Efficacy Beliefs

NASA Astrophysics Data System (ADS)

Bautista, Nazan Uludag; Boone, William J.

2015-04-01

The purpose of this study was to investigate the impact of a mixed-reality teaching environment, called TeachME™ Lab (TML), on early childhood education majors' science teaching self-efficacy beliefs. Sixty-two preservice early childhood teachers participated in the study. Analysis of the quantitative (STEBI-b) and qualitative (journal entries) data revealed that personal science teaching efficacy and science teaching outcome expectancy beliefs increased significantly after one semester of participation in TML. Three key factors impacted preservice teachers' (PST) self-efficacy beliefs in the context of participation in TML: PSTs' perceptions of their science content knowledge, their familiarity with TML technology and avatars, and being observed by peers. Cognitive pedagogical mastery (TML practices), effective/actual modeling, cognitive self-modeling, and emotional arousal were the primary sources that increased the PSTs' perceived self-efficacy beliefs. Overall, the results of this study suggest that the TML is a worthwhile technology for learning to teach in teacher education. It provides a way for PSTs to have a highly personalized learning experience that enables them to improve their understanding and confidence related to teaching science, so that ideally someday they may translate such an experience into their classroom practices.

Climate change, air pollution, and allergic respiratory diseases: an update.

PubMed

D'Amato, Gennaro; Vitale, Carolina; Lanza, Maurizia; Molino, Antonio; D'Amato, Maria

2016-10-01

The rising trend in prevalence of allergic respiratory disease and bronchial asthma, observed over the last decades, can be explained by changes occurring in the environment, with increasing presence of biologic, such as allergens, and chemical atmospheric trigger factors able to stimulate the sensitization and symptoms of these diseases. Many studies have shown changes in production, dispersion, and allergen content of pollen and spores because of climate change with an increasing effect of aeroallergens on allergic patients. Over the last 50 years, global earth's temperature has markedly risen likely because of growing emission of anthropogenic greenhouse gas concentrations. Major changes involving the atmosphere and the climate, including global warming induced by human activity, have a major impact on the biosphere and human environment.Urbanization and high levels of vehicle emissions are correlated to an increase in the frequency of pollen-induced respiratory allergy prevalent in people who live in urban areas compared with those who live in rural areas. Measures of mitigation need to be applied for reducing future impacts of climate change on our planet, but until global emissions continue to rise, adaptation to the impacts of future climate variability will also be required.

Effects of diesel particle filter retrofits and accelerated fleet turnover on drayage truck emissions at the Port of Oakland.

PubMed

Dallmann, Timothy R; Harley, Robert A; Kirchstetter, Thomas W

2011-12-15

Heavy-duty diesel drayage trucks have a disproportionate impact on the air quality of communities surrounding major freight-handling facilities. In an attempt to mitigate this impact, the state of California has mandated new emission control requirements for drayage trucks accessing ports and rail yards in the state beginning in 2010. This control rule prompted an accelerated diesel particle filter (DPF) retrofit and truck replacement program at the Port of Oakland. The impact of this program was evaluated by measuring emission factor distributions for diesel trucks operating at the Port of Oakland prior to and following the implementation of the emission control rule. Emission factors for black carbon (BC) and oxides of nitrogen (NO(x)) were quantified in terms of grams of pollutant emitted per kilogram of fuel burned using a carbon balance method. Concentrations of these species along with carbon dioxide were measured in the exhaust plumes of individual diesel trucks as they drove by en route to the Port. A comparison of emissions measured before and after the implementation of the truck retrofit/replacement rule shows a 54 ± 11% reduction in the fleet-average BC emission factor, accompanied by a shift to a more highly skewed emission factor distribution. Although only particulate matter mass reductions were required in the first year of the program, a significant reduction in the fleet-average NO(x) emission factor (41 ± 5%) was observed, most likely due to the replacement of older trucks with new ones.

Factors contributing to academic achievement: a Bayesian structure equation modelling study

NASA Astrophysics Data System (ADS)

Payandeh Najafabadi, Amir T.; Omidi Najafabadi, Maryam; Farid-Rohani, Mohammad Reza

2013-06-01

In Iran, high school graduates enter university after taking a very difficult entrance exam called the Konkoor. Therefore, only the top-performing students are admitted by universities to continue their bachelor's education in statistics. Surprisingly, statistically, most of such students fall into the following categories: (1) do not succeed in their education despite their excellent performance on the Konkoor and in high school; (2) graduate with a grade point average (GPA) that is considerably lower than their high school GPA; (3) continue their master's education in majors other than statistics and (4) try to find jobs unrelated to statistics. This article employs the well-known and powerful statistical technique, the Bayesian structural equation modelling (SEM), to study the academic success of recent graduates who have studied statistics at Shahid Beheshti University in Iran. This research: (i) considered academic success as a latent variable, which was measured by GPA and other academic success (see below) of students in the target population; (ii) employed the Bayesian SEM, which works properly for small sample sizes and ordinal variables; (iii), which is taken from the literature, developed five main factors that affected academic success and (iv) considered several standard psychological tests and measured characteristics such as 'self-esteem' and 'anxiety'. We then study the impact of such factors on the academic success of the target population. Six factors that positively impact student academic success were identified in the following order of relative impact (from greatest to least): 'Teaching-Evaluation', 'Learner', 'Environment', 'Family', 'Curriculum' and 'Teaching Knowledge'. Particularly, influential variables within each factor have also been noted.

ERK-dependent phosphorylation of the transcription initiation factor TIF-IA is required for RNA polymerase I transcription and cell growth.

PubMed

Zhao, Jian; Yuan, Xuejun; Frödin, Morten; Grummt, Ingrid

2003-02-01

Phosphorylation of transcription factors by mitogen-activated protein kinase (MAPK) cascades links cell signaling with the control of gene expression. Here we show that growth factors induce rRNA synthesis by activating MAPK-dependent signaling cascades that target the RNA polymerase I-specific transcription initiation factor TIF-IA. Activation of TIF-IA and ribosomal gene transcription is sensitive to PD98059, indicating that TIF-IA is targeted by MAPK in vivo. Phosphopeptide mapping and mutational analysis reveals two serine residues (S633 and S649) that are phosphorylated by ERK and RSK kinases. Replacement of S649 by alanine inactivates TIF-IA, inhibits pre-rRNA synthesis, and retards cell growth. The results provide a link between growth factor signaling, ribosome production, and cell growth, and may have a major impact on the mechanism of cell transformation.

Impact of emotional intelligence and spiritual intelligence on the caring behavior of nurses: a dimension-level exploratory study among public hospitals in Malaysia.

PubMed

Kaur, Devinder; Sambasivan, Murali; Kumar, Naresh

2015-11-01

The purpose of this research is to study the impact of individual factors such as emotional intelligence (EI) and spiritual intelligence (SI) on the caring behavior of nurses. A cross-sectional survey using questionnaire was conducted by sampling 550 nurses working in seven major public hospitals in Malaysia. Data were analyzed using structural equation modeling (SEM). The main findings are: (1) critical existential thinking and transcendental awareness dimensions of SI have significant impacts on assurance of human presence dimension of caring behavior; (2) personal meaning production and conscious state expansion dimensions of SI have significant impacts on perception of emotion and managing own emotions dimensions of EI; and (3) managing own emotions dimension of EI has significant impacts on respectful deference to other and assurance of human presence dimensions of caring behavior of nurses. The results can be used to recruit and educate nurses. Copyright © 2015 Elsevier Inc. All rights reserved.

Coffee consumption vs. cancer risk - a review of scientific data.

PubMed

Wierzejska, Regina

2015-01-01

Coffee and its impact on health continue to be the topic of much heated debate. Until recently, coffee consumption has been believed to be associated with adverse effects, mainly cardiovascular problems. However, the vast majority of contemporary sources not only emphasize a lack of detrimental effect, but also suggest a beneficial effect of coffee intake. According to the current state of knowledge, coffee consumption is not associated with the majority of cancers although the results of studies on bladder and lung cancer remain conflicting. In case of colorectal, liver and breast cancers, coffee drinking may even have a protective effect. Coffee contains numerous compounds, potentially beneficial as well as harmful. The former include polyphenols which inhibit harmful oxidation processes in the body, while the latter include acrylamide, whose high intake in daily diet may have carcinogenic action. The impact of coffee on the human body is associated also with other factors, e.g. the rate of metabolism and other individual features.

Age-Related Macular Degeneration: Genetics and Biology Coming Together

PubMed Central

Fritsche, Lars G.; Fariss, Robert N.; Stambolian, Dwight; Abecasis, Gonçalo R.; Curcio, Christine A.

2014-01-01

Genetic and genomic studies have enhanced our understanding of complex neurodegenerative diseases that exert a devastating impact on individuals and society. One such disease, age-related macular degeneration (AMD), is a major cause of progressive and debilitating visual impairment. Since the pioneering discovery in 2005 of complement factor H (CFH) as a major AMD susceptibility gene, extensive investigations have confirmed 19 additional genetic risk loci, and more are anticipated. In addition to common variants identified by now-conventional genome-wide association studies, targeted genomic sequencing and exome-chip analyses are uncovering rare variant alleles of high impact. Here, we provide a critical review of the ongoing genetic studies and of common and rare risk variants at a total of 20 susceptibility loci, which together explain 40–60% of the disease heritability but provide limited power for diagnostic testing of disease risk. Identification of these susceptibility loci has begun to untangle the complex biological pathways underlying AMD pathophysiology, pointing to new testable paradigms for treatment. PMID:24773320

Evoluton of the Tharsis Region of Mars

NASA Astrophysics Data System (ADS)

Anderson, R. C.; Dohm, J. M.; Maruyama, S.

2015-12-01

The evolution of the Tharsis region includes at least five major stages of Tharsis-related activity, which includes the formation of igneous plateaus, canyon and fault systems, volcanoes, and centers of magmatic-driven tectonism. This activity drove major environmental changes that were recorded in the walls of Valles Marineris, the circum-Chryse outflow channel system, the northern plains, and impact basins such as Argyre, among many other Martian features and landscapes. Environmental change included flooding and associated formation of lakes and oceans in basins such as the prominent northern plains and impact basins such as Argyre. This Tharsis-driven activity also included the formation of glaciers in the southern hemisphere and other landscape features (e.g., alluvial fans, periglacial landforms, gelifluction features including mass wasting, fluvial channels) indicative of an active landscape. At this conference, we will present the details of the evolution of Tharsis, as well as discuss contributing factors to its origin, estimated beginning development, and explanations for its longevity.

Physiologic and psychobehavioral research in oncology.

PubMed

Redd, W H; Silberfarb, P M; Andersen, B L; Andrykowski, M A; Bovbjerg, D H; Burish, T G; Carpenter, P J; Cleeland, C; Dolgin, M; Levy, S M

1991-02-01

A major thrust in research in psychosocial oncology is the study of the interaction of psychologic and physiologic variables. This discussion reviews the current status and future directions of such research. Areas addressed include pain, nausea and vomiting with chemotherapy, sexuality, effects of cancer on psychologic and neuropsychologic function, impact of psychologic factors on cancer and its treatment, and psychoneuroimmunology. In addition, specific recommendations for strategies to facilitate research in these areas of psychosocial oncology are proposed.

Intellectual Performance Under Stress

DTIC Science & Technology

1976-09-01

graduate programs around the country. Taken together these lists constitute a demonstration of the important “ filter down” impact of money spent on...skills research of th 1950’s and ear ly ‘60’s. A major contributing factor to the pursuit of analytic, explanatory models of skilled performance, aside...and in combination with one and with both of the other two tasks. Tracking performance was described by the Crossover Model of McRuer and Krendel (1959

Analysis and fifteen-year projection of the market for LANDSAT data

NASA Technical Reports Server (NTRS)

1981-01-01

The potential market for LANDSAT products through the 1990's was determined. Results are presented in a matrix format. Improved resolution is a major factor in the marketability of LANDSAT data, the 10 meter resolution (projected for 1995) having a significant impact on the federal, private, and international users, and on the agricultural, minerals, and national defense applications. Data delivery time and competition from the French remote sensing system are considered.

"A 28-Day Program Ain't Helping the Crack Smoker" -- Perceptions of Effective Drug Abuse Prevention Interventions by North Central Florida African Americans Who Use Cocaine

ERIC Educational Resources Information Center

Brown, Emma J.; Hill, Mary Angelique; Giroux, Stacey A.

2004-01-01

Cocaine is a major problem in the rural South, but knowledge is limited regarding the impact on African American populations. Purpose: This study of 18-39-year-old black drug users assessed perceptions of contributing factors to drug use and possible interventions. The study design was qualitative-descriptive, utilizing 4 focus groups with 5 rural…

Designing learning environments to promote student learning: ergonomics in all but name.

PubMed

Smith, Thomas J

2013-01-01

This report introduces evidence for the conclusion that a common theme underlies almost all proposed solutions for improving the performance of K-12 students, namely their reliance on the design of educational system environments, features and operations. Two categories of design factors impacting such performance are addressed: (1) 9 factors reliably shown to have a strong influence - namely environmental design of classroom and building facilities, longer exposure to learning, cooperative learning designs, early childhood education, teaching quality, nutritional adequacy, participation in physical activity, good physical fitness, and school-community integration; and (2) 11 factors with an equivocal, varied or weak influence - classroom technology, online learning environments, smaller class size, school choice, school funding, school size, school start times, teacher training level, amount of homework, student self-confidence and informal learning. It is concluded that: (1) student learning outcomes, and more broadly the edifice of education itself, are largely defined in terms of an extensive system of design factors and conditions; (2) the time is long overdue for the educational system to acknowledge the central role of E/HF design as the major influence on student performance and learning; and (3) K-12 educators and administrators should emphasize allocation of resources to design factors reliably shown to have a strongly positive impact on student performance, but should treat expenditure on factors with equivocal, varied or weak influence on such performance with more caution and/or skepticism.

Critical factors for the return-to-work process among people with affective disorders: Voices from two vocational approaches.

PubMed

Porter, Susann; Lexén, Annika; Johansson, Suzanne; Bejerholm, Ulrika

2018-05-22

Depression is among the major causes of disability with a negative impact on both daily life and work performance. Whilst depression is the primary cause of sick-leave and unemployment in today's workplace there is a lack of knowledge of the needs of individuals with depression regarding their return-to-work (RTW) process. To explore which factors are of critical importance for people suffering from depression and who also are unemployed in their RTW-process and to explore the impact of two vocational approaches on the service users' experiences. The study included participants in two vocational rehabilitation approaches; Individual Enabling and Support (IES) and Traditional Vocational Rehabilitation (TVR). Qualitative methods were applied to explore critical factors in the RTW-process. Individuals with affective disorders including depression and bipolar disorder were included.RESULTSThree themes emerged as critical factors; Experiencing hope and power, Professionals' positive attitudes, beliefs and behaviours, and Employing a holistic perspective and integrating health and vocational service.CONCLUSIONThis study has demonstrated critical factors for the return-to-work process as experienced by persons with depression. To experience hope and power, to meet professionals that believe "you can work", who use a person-centred and holistic service approach, are such factors necessary for gaining a real job. In particular, professionals in TVR need to embrace this understanding since their services were not experienced as including these elements.

Metabolic syndrome and its components after liver transplantation: incidence, prevalence, risk factors, and implications.

PubMed

Anastácio, Lucilene Rezende; Lima, Agnaldo Soares; Toulson Davisson Correia, Maria Isabel

2010-04-01

Metabolic syndrome is defined as the mutual existence of obesity, impaired fasting glucose levels, insulin resistance, hypertension, and dyslipidemia. After liver transplantation, patients typically develop these disorders, and even though there has been minimal research focused on the chronic impact of this syndrome on post-liver transplant patients, studies point to an association with major vascular events and fibrosis. The aim of the current work is to review data on the incidence, prevalence, risk factors, and implications of metabolic syndrome and its components in patients who have undergone liver transplantation. Copyright 2009 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

Eco-Material Selection for Auto Bodies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mayyas, Ahmad T; Omar, Mohammed; Hayajneh, Mohammed T.

In the last decades, majority of automakers started to include lightweight materials in their vehicles to meet hard environmental regulations and to improve fuel efficiency of their vehicles. As a result, eco-material selection for vehicles emerged as a new discipline under design for environment. This chapter will summarize methods of eco-material selections for automotive applications with more emphasis into auto-bodies. A set of metrics for eco-material selection that takes into account all economic, environmental and social factors will be developed using numerical and qualitative methods. These metrics cover products' environmental impact, functionality and manufacturability, in addition to the economic andmore » societal factors.« less

Cancer and liver cirrhosis: implications on prognosis and management

PubMed Central

Pinter, Matthias; Trauner, Michael; Peck-Radosavljevic, Markus; Sieghart, Wolfgang

2016-01-01

Liver cirrhosis, the end-stage of every chronic liver disease, is not only the major risk factor for the development of hepatocellular carcinoma but also a limiting factor for anticancer therapy of liver and non-hepatic malignancies. Liver cirrhosis may limit surgical and interventional approaches to cancer treatment, influence pharmacokinetics of anticancer drugs, increase side effects of chemotherapy, render patients susceptible for hepatotoxicity, and ultimately result in a competitive risk for morbidity and mortality. In this review, we provide a concise overview about the impact of liver cirrhosis on the management and prognosis of patients with primary liver cancer or non-hepatic malignancies. PMID:27843598

Tuberculosis Control in South African Gold Mines: Mathematical Modeling of a Trial of Community-Wide Isoniazid Preventive Therapy

PubMed Central

Vynnycky, Emilia; Sumner, Tom; Fielding, Katherine L.; Lewis, James J.; Cox, Andrew P.; Hayes, Richard J.; Corbett, Elizabeth L.; Churchyard, Gavin J.; Grant, Alison D.; White, Richard G.

2015-01-01

A recent major cluster randomized trial of screening, active disease treatment, and mass isoniazid preventive therapy for 9 months during 2006–2011 among South African gold miners showed reduced individual-level tuberculosis incidence but no detectable population-level impact. We fitted a dynamic mathematical model to trial data and explored 1) factors contributing to the lack of population-level impact, 2) the best-achievable impact if all implementation characteristics were increased to the highest level achieved during the trial (“optimized intervention”), and 3) how tuberculosis might be better controlled with additional interventions (improving diagnostics, reducing treatment delay, providing isoniazid preventive therapy continuously to human immunodeficiency virus–positive people, or scaling up antiretroviral treatment coverage) individually and in combination. We found the following: 1) The model suggests that a small proportion of latent infections among human immunodeficiency virus–positive people were cured, which could have been a key factor explaining the lack of detectable population-level impact. 2) The optimized implementation increased impact by only 10%. 3) Implementing additional interventions individually and in combination led to up to 30% and 75% reductions, respectively, in tuberculosis incidence after 10 years. Tuberculosis control requires a combination prevention approach, including health systems strengthening to minimize treatment delay, improving diagnostics, increased antiretroviral treatment coverage, and effective preventive treatment regimens. PMID:25792607

Prevalence and factors associated with depression among medical students in Cameroon: a cross-sectional study.

PubMed

Ngasa, Stewart Ndutard; Sama, Carlson-Babila; Dzekem, Bonaventure Suiru; Nforchu, Kilton Neba; Tindong, Maxime; Aroke, Desmond; Dimala, Christian Akem

2017-06-09

Depression is an important contributor to the global burden disease that affects people of communities all over the world. With high level of demands in academics and psychosocial pressure, medical students during their course of training tend to become depressed, leading to problems later in professional life and compromising patient care. In Cameroon, there is lack of data on the prevalence of depression and its impact on medical students. To determine the prevalence and predisposing factors associated with depression among medical students in Cameroon (preclinical and clinical). We also evaluated the impact of depression on self-reported academic performance. A cross sectional study was carried out in all 4 state medical schools in 4 different regions from December 2015 to January 2016. Diagnosis of depression, major depression and its associated factors were assessed using the 9-Item-Patient Health Questionnaire (PHQ-9) and a structured questionnaire respectively. We included 618 medical students (response rate: 90.4%). About a third of them (30.6%, 95% CI: 22.8-36.7) were found to have major depressive disorder (PHQ Score ≥ 10). With regards to the severity of depression, 214 (34.6%), 163 (26.4%), 21 (3.4%), and 5 (0.80%) students were classified as having mild, moderate, moderately severe and severe depression respectively. The presence of a chronic disease (OR: 3.70, 95% CI: 1.72-7.94, p = 0.001), major life events (OR: 2.17, 95%CI: 1.32-3.58, P = 0.002), female gender (OR: 1.59, 95% CI: 1.06-2.37, p = 0.024) and being a student at the clinical level (OR: 4.26, 95% CI: 2.71-6.71, p < 0.001) were independently associated with depression. There was no association between depression and self-reported academic performance, (OR: 1.2, 95% CI: 0.9-1.7, p = 0.080). The prevalence of major depressive disorders among medical students in Cameroon is high and is associated with the presence chronic disease, major life events, female gender and being a student at the clinical level. So we recommend clinicians attending to medical students with demographic features suggestive of greater risk of depression, to make an in depth investigation on the possible presence of depression. Despite this high prevalence of major depression among medical students, it was not associated with self-reported academic performance.

Student and high-school characteristics related to completing a science, technology, engineering or mathematics (STEM) major in college

NASA Astrophysics Data System (ADS)

LeBeau, Brandon; Harwell, Michael; Monson, Debra; Dupuis, Danielle; Medhanie, Amanuel; Post, Thomas R.

2012-04-01

Background: The importance of increasing the number of US college students completing degrees in science, technology, engineering or mathematics (STEM) has prompted calls for research to provide a better understanding of factors related to student participation in these majors, including the impact of a student's high-school mathematics curriculum. Purpose: This study examines the relationship between various student and high-school characteristics and completion of a STEM major in college. Of specific interest is the influence of a student's high-school mathematics curriculum on the completion of a STEM major in college. Sample: The sample consisted of approximately 3500 students from 229 high schools. Students were predominantly Caucasian (80%), with slightly more males than females (52% vs 48%). Design and method: A quasi-experimental design with archival data was used for students who enrolled in, and graduated from, a post-secondary institution in the upper Midwest. To be included in the sample, students needed to have completed at least three years of high-school mathematics. A generalized linear mixed model was used with students nested within high schools. The data were cross-sectional. Results: High-school predictors were not found to have a significant impact on the completion of a STEM major. Significant student-level predictors included ACT mathematics score, gender and high-school mathematics GPA. Conclusions: The results provide evidence that on average students are equally prepared for the rigorous mathematics coursework regardless of the high-school mathematics curriculum they completed.

Nurses' Perceptions of Implementing Fall Prevention Interventions to Mitigate Patient-Specific Fall Risk Factors.

PubMed

Wilson, Deleise S; Montie, Mary; Conlon, Paul; Reynolds, Margaret; Ripley, Robert; Titler, Marita G

2016-08-01

Evidence-based (EB) fall prevention interventions to mitigate patient-specific fall risk factors are readily available but not routinely used in practice. Few studies have examined nurses' perceptions about both the use of these EB interventions and implementation strategies designed to promote their adoption. This article reports qualitative findings of nurses' perceptions about use of EB fall prevention interventions to mitigate patient-specific fall risks, and implementation strategies to promote use of these interventions. The findings revealed five major themes: before-study fall prevention practices, use of EB fall prevention interventions tailored to patient-specific fall risk factors, beneficial implementation strategies, overall impact on approach to fall prevention, and challenges These findings are useful to guide nurses' engagement and use of EB fall prevention practices tailored to patient-specific fall risk factors. © The Author(s) 2016.

Affect and Health Behavior Co-Occurrence: The Emerging Roles of Transdiagnostic Factors and Sociocultural Factors.

PubMed

Zvolensky, Michael J; Leventhal, Adam M

2016-01-01

The majority of scientific work addressing relations among affective states and health correlates has focused primarily on their co-occurrence and a limited range of health conditions. We have developed a Special Issue to highlight recent advances in this emerging field of work that addresses the nature and interplay between affective states and disorders, in terms of their impact and consequences from health status and behavior. This Special Issue is organized into three parts classified as (a) co-occurrence and interplay between (b) transdiagnostic factors and (c) sociocultural factors. It is hoped that this issue will (a) alert readers to the significance of this work at different levels of analysis, (b) illustrate the many domains currently being explored via innovative approaches, and (c) identify fecund areas for future systematic study. © The Author(s) 2016.

Calculation of the Pitot tube correction factor for Newtonian and non-Newtonian fluids.

PubMed

Etemad, S Gh; Thibault, J; Hashemabadi, S H

2003-10-01

This paper presents the numerical investigation performed to calculate the correction factor for Pitot tubes. The purely viscous non-Newtonian fluids with the power-law model constitutive equation were considered. It was shown that the power-law index, the Reynolds number, and the distance between the impact and static tubes have a major influence on the Pitot tube correction factor. The problem was solved for a wide range of these parameters. It was shown that employing Bernoulli's equation could lead to large errors, which depend on the magnitude of the kinetic energy and energy friction loss terms. A neural network model was used to correlate the correction factor of a Pitot tube as a function of these three parameters. This correlation is valid for most Newtonian, pseudoplastic, and dilatant fluids at low Reynolds number.

Spatial And Temporal Patterns As Well As Major Influencing Factors Of Global And Diffuse Horizontal Irradiance Over China: 1960-2014

NASA Astrophysics Data System (ADS)

Wang, H.; Sun, F.

2017-12-01

Global Horizontal Irradiance (GHI) on Earth is a central element of climate systems. With changes in the climate and regional development, the patterns and influencing factors of GHI, in addition to presenting global consistency, are increasingly showing regional particularities. Based on data for GHI, Diffuse Horizontal Irradiance (DHI) and potential impact factors (geographical position, elevation, cloud cover, water vapor, and ground atmospheric transparency related variables) from 1960 to 2014 in China, we analyzed the pattern and major influencing factors of GHI and DHI. The results showed that the major influencing factors of the GHI spatial pattern were the total cloud cover (TCC) and relative humidity (RH) in China. Dividing all of China into two regions, the major factors were the water vapor pressure (WVP) in the northern region and TCC in the southern region. And we divided the GHI and DHI data into two periods (1960-1987 and 1988-2014) due to global dimming and brightening observed in China in the late 1980's. The temporal GHI showed that 31 of 58 decreased significantly with an average decreasing rate of 95 MJ.10yr-1 during the periods of 1960-2014 and 49 of 76 stations decreased significantly with an rate of 342 MJ.10yr-1 during 1960-1987, whereas 57 of 88 stations did not change and 24 stations increased significantly with an rate of 201 MJ.10yr-1 during the period of 1988-2014. The temporal DHI showed that 40 of 61sites did not change significantly from 1960 to 1987. The major influencing factors for temporal changes of GHI in nine typical cities from 1960 to 2013 were as follows: air quality-related variables in super cities, sandstorms and wind in desert oasis cities, clouds in cities with good air quality and a low cloud amount (LCA) and annual fog days (FD) in Chengdu. Overall, we identified characteristics of GHI and DHI based on global climate change and regional urban development and found that the spatial characteristics of GHI results for China are consistent with global trends, whereas the spatial characteristics of DHI and temporal characteristics of GHI and DHI have changed significantly.

Enduring financial crisis in Greece: prevalence and correlates of major depression and suicidality.

PubMed

Economou, Marina; Angelopoulos, Elias; Peppou, Lily Evangelia; Souliotis, Kyriakos; Tzavara, Chara; Kontoangelos, Konstantinos; Madianos, Michael; Stefanis, Costas

2016-07-01

A series of repeated cross-sectional surveys conducted in 2008, 2009, 2011 and 2013 were conducted with the aim of estimating the prevalence of major depression and suicidality as well as of investigating its risk factors. The present report concentrates on the 2013 survey. A random and representative sample of 2.188 people was telephone interviewed with regard to various socio-economic indicators and the presence of major depression and suicidality, which were assessed with the germane module of the Structured Clinical Interview. Findings suggest a rise in 1-month prevalence of major depression (12.3 %) and a decline in prevalence of suicidality (2.8 %). Female gender, residence in rural area, low educational attainment, unemployment and economic hardship were found to increase the odds of suffering from major depression. The influence of economic hardship and unemployment on suicidality was also substantial and independent of major depression. Results stress the imperative need for the design and implementation of social policies and interventions that would offset the dire impact of the sustained recession in Greece.

An uncertainty-based framework to quantifying climate change impacts on coastal flood vulnerability: case study of New York City.

PubMed

Zahmatkesh, Zahra; Karamouz, Mohammad

2017-10-17

The continued development efforts around the world, growing population, and the increased probability of occurrence of extreme hydrologic events have adversely affected natural and built environments. Flood damages and loss of lives from the devastating storms, such as Irene and Sandy on the East Coast of the USA, are examples of the vulnerability to flooding that even developed countries have to face. The odds of coastal flooding disasters have been increased due to accelerated sea level rise, climate change impacts, and communities' interest to live near the coastlines. Climate change, for instance, is becoming a major threat to sustainable development because of its adverse impacts on the hydrologic cycle. Effective management strategies are thus required for flood vulnerability reduction and disaster preparedness. This paper is an extension to the flood resilience studies in the New York City coastal watershed. Here, a framework is proposed to quantify coastal flood vulnerability while accounting for climate change impacts. To do so, a multi-criteria decision making (MCDM) approach that combines watershed characteristics (factors) and their weights is proposed to quantify flood vulnerability. Among the watershed characteristics, potential variation in the hydrologic factors under climate change impacts is modeled utilizing the general circulation models' (GCMs) outputs. The considered factors include rainfall, extreme water level, and sea level rise that exacerbate flood vulnerability through increasing exposure and susceptibility to flooding. Uncertainty in the weights as well as values of factors is incorporated in the analysis using the Monte Carlo (MC) sampling method by selecting the best-fitted distributions to the parameters with random nature. A number of low impact development (LID) measures are then proposed to improve watershed adaptive capacity to deal with coastal flooding. Potential range of current and future vulnerability to flooding is estimated with and without consideration of climate change impacts and after implementation of LIDs. Results show that climate change has the potential to increase rainfall intensity, flood volume, floodplain extent, and flood depth in the watershed. The results also reveal that improving system resilience by reinforcing the adaptation capacity through implementing LIDs could mitigate flood vulnerability. Moreover, the results indicate the significant effect of uncertainties, arising from the factors' weights as well as climate change, impacts modeling approach, on quantifying flood vulnerability. This study underlines the importance of developing applicable schemes to quantify coastal flood vulnerability for evolving future responses to adverse impacts of climate change.

Factors Associated with the Competencies of Public Health Workers in Township Hospitals: A Cross-Sectional Survey in Chongqing Municipality, China

PubMed Central

He, Zhifei; Cheng, Zhaohui; Fu, Hang; Tang, Shangfeng; Fu, Qian; Fang, Haiqing; Xian, Yue; Ming, Hui; Feng, Zhanchun

2015-01-01

Purpose: This study aimed to explore the competencies of public health workers (PHWs) of township hospitals in Chongqing Municipality (China), and determine the related impact factors of the competencies of PHWs; Methods: A cross-sectional research was conducted on 314 PHWs from 27 township hospitals in three districts in Chongqing Municipality (China), from June to August 2014. A self-assessment questionnaire was established on the basis of literature reviews and a competency dictionary. The differences in competencies among the three districts were determined by adopting the chi-square test, t-test, analysis of variance (ANOVA) method, and the impact factors of the competencies of PHWs were determined by adopting stepwise regression analysis. Results: (1) Results of the demographic characteristics of PHWs in three sample districts of Chongqing Municipality showed that a significant difference in age of PHWs (p = 0.021 < 0.05) and the majors of PHWs (p = 0.045 < 0.05); (2) In terms of the self-evaluation competency results of PHWs in township hospitals, seven among the 11 aspects were found to have significant differences in the three districts by the ANOVA test; (3) By adopting the t-test and ANOVA method, results of the relationship between the characteristics of PHWs and their competency scores showed that significant differences were found in the economic level (p = 0.000 < 0.05), age (p = 0.000 < 0.05), years of working (p = 0.000 < 0.05) and title of PHWs (p = 0.000 < 0.05); (4) Stepwise regression analysis was used to determine the impact factors of the competencies of PHWs in township hospitals, including the economic level (p = 0.000 < 0.001), years of working (p = 0.000 < 0.001), title (p = 0.001 < 0.005), and public health major (p = 0.007 < 0.01). Conclusions: The competencies of the township hospital staff in Chongqing Municipality (China), are generally insufficient, therefore, regulating the medical education and training skills of PHWs is crucial to improve the competencies of PHWs in the township hospitals of Chongqing Municipality. The results of this study can be mirrored in other areas of China. PMID:26569273

Factors impacting the efficacy of venlafaxine extended release 75–225 mg/day in patients with major depressive disorder: exploratory post hoc subgroup analyses of a randomized, double-blind, placebo-controlled study in Japan

PubMed Central

Watanabe, Yoshinori; Asami, Yuko; Hirano, Yoko; Kuribayashi, Kazuhiko; Itamura, Rio; Imaeda, Takayuki

2018-01-01

Purpose To explore the potential factors impacting the efficacy of venlafaxine extended release (ER) and treatment differences between 75 mg/day and 75–225 mg/day dose in patients with major depressive disorder (MDD). Methods We performed exploratory post hoc subgroup analyses of a randomized, double-blind, placebo-controlled study conducted in Japan. A total of 538 outpatients aged 20 years or older with a primary diagnosis of MDD who experienced single or recurrent episodes were randomized into three groups: fixed-dose, flexible-dose, or placebo. Venlafaxine ER was initiated at 37.5 mg/day and titrated to 75 mg/day for both fixed-dose and flexible-dose group, and to 225 mg/day for flexible-dose group (if well tolerated). Efficacy endpoints were changes from baseline at Week 8 using the Hamilton Rating Scale for Depression–17 items (HAM-D17) total score, Hamilton Rating Scale for Depression–6 items score, and Montgomery–Asberg Depression Rating Scale total score. The following factors were considered in the subgroup analyses: sex, age, HAM-D17 total score at baseline, duration of MDD, duration of current depressive episode, history of previous depressive episodes, history of previous medications for MDD, and CYP2D6 phenotype. For each subgroup, an analysis of covariance model was fitted and the adjusted mean of the treatment effect and corresponding 95% CI were computed. Due to the exploratory nature of the investigation, no statistical hypothesis testing was used. Results Venlafaxine ER improved symptoms of MDD compared with placebo in most subgroups. The subgroup with a long duration of MDD (>22 months) consistently showed greater treatment benefits in the flexible-dose group than in the fixed-dose group. Conclusion These results suggest that a greater treatment response to venlafaxine ER (up to 225 mg/day) can be seen in patients with a longer duration of MDD. Further investigations are needed to identify additional factors impacting the efficacy of venlafaxine ER. PMID:29844674

Factors Associated with the Competencies of Public Health Workers in Township Hospitals: A Cross-Sectional Survey in Chongqing Municipality, China.

PubMed

He, Zhifei; Cheng, Zhaohui; Fu, Hang; Tang, Shangfeng; Fu, Qian; Fang, Haiqing; Xian, Yue; Ming, Hui; Feng, Zhanchun

2015-11-09

This study aimed to explore the competencies of public health workers (PHWs) of township hospitals in Chongqing Municipality (China), and determine the related impact factors of the competencies of PHWs; A cross-sectional research was conducted on 314 PHWs from 27 township hospitals in three districts in Chongqing Municipality (China), from June to August 2014. A self-assessment questionnaire was established on the basis of literature reviews and a competency dictionary. The differences in competencies among the three districts were determined by adopting the chi-square test, t-test, analysis of variance (ANOVA) method, and the impact factors of the competencies of PHWs were determined by adopting stepwise regression analysis. (1) RESULTS of the demographic characteristics of PHWs in three sample districts of Chongqing Municipality showed that a significant difference in age of PHWs (p = 0.021 < 0.05) and the majors of PHWs (p = 0.045 < 0.05); (2) In terms of the self-evaluation competency results of PHWs in township hospitals, seven among the 11 aspects were found to have significant differences in the three districts by the ANOVA test; (3) By adopting the t-test and ANOVA method, results of the relationship between the characteristics of PHWs and their competency scores showed that significant differences were found in the economic level (p = 0.000 < 0.05), age (p = 0.000 < 0.05), years of working (p = 0.000 < 0.05) and title of PHWs (p = 0.000 < 0.05); (4) Stepwise regression analysis was used to determine the impact factors of the competencies of PHWs in township hospitals, including the economic level (p = 0.000 < 0.001), years of working (p = 0.000 < 0.001), title (p = 0.001 < 0.005), and public health major (p = 0.007 < 0.01). The competencies of the township hospital staff in Chongqing Municipality (China), are generally insufficient, therefore, regulating the medical education and training skills of PHWs is crucial to improve the competencies of PHWs in the township hospitals of Chongqing Municipality. The results of this study can be mirrored in other areas of China.

Factors impacting the efficacy of venlafaxine extended release 75-225 mg/day in patients with major depressive disorder: exploratory post hoc subgroup analyses of a randomized, double-blind, placebo-controlled study in Japan.

PubMed

Watanabe, Yoshinori; Asami, Yuko; Hirano, Yoko; Kuribayashi, Kazuhiko; Itamura, Rio; Imaeda, Takayuki

2018-01-01

To explore the potential factors impacting the efficacy of venlafaxine extended release (ER) and treatment differences between 75 mg/day and 75-225 mg/day dose in patients with major depressive disorder (MDD). We performed exploratory post hoc subgroup analyses of a randomized, double-blind, placebo-controlled study conducted in Japan. A total of 538 outpatients aged 20 years or older with a primary diagnosis of MDD who experienced single or recurrent episodes were randomized into three groups: fixed-dose, flexible-dose, or placebo. Venlafaxine ER was initiated at 37.5 mg/day and titrated to 75 mg/day for both fixed-dose and flexible-dose group, and to 225 mg/day for flexible-dose group (if well tolerated). Efficacy endpoints were changes from baseline at Week 8 using the Hamilton Rating Scale for Depression-17 items (HAM-D 17 ) total score, Hamilton Rating Scale for Depression-6 items score, and Montgomery-Asberg Depression Rating Scale total score. The following factors were considered in the subgroup analyses: sex, age, HAM-D 17 total score at baseline, duration of MDD, duration of current depressive episode, history of previous depressive episodes, history of previous medications for MDD, and CYP2D6 phenotype. For each subgroup, an analysis of covariance model was fitted and the adjusted mean of the treatment effect and corresponding 95% CI were computed. Due to the exploratory nature of the investigation, no statistical hypothesis testing was used. Venlafaxine ER improved symptoms of MDD compared with placebo in most subgroups. The subgroup with a long duration of MDD (>22 months) consistently showed greater treatment benefits in the flexible-dose group than in the fixed-dose group. These results suggest that a greater treatment response to venlafaxine ER (up to 225 mg/day) can be seen in patients with a longer duration of MDD. Further investigations are needed to identify additional factors impacting the efficacy of venlafaxine ER.

An assessment of predominant causal factors of pilot deviations that contribute to runway incursions

NASA Astrophysics Data System (ADS)

Campbell, Denado M.

The aim of this study was to identify predominant causal factors of pilot deviations in runway incursions over a two-year period. Runway incursion reports were obtained from NASA's Aviation Safety Reporting System (ASRS), and a qualitative method was used by classifying and coding each report to a specific causal factor(s). The causal factors that were used were substantiated by research from the Aircraft Owner's and Pilot's Association that found that these causal factors were the most common in runway incursion incidents and accidents. An additional causal factor was also utilized to determine the significance of pilot training in relation to runway incursions. From the reports examined, it was found that miscommunication and situational awareness have the greatest impact on pilots and are most often the major causes of runway incursions. This data can be used to assist airports, airlines, and the FAA to understand trends in pilot deviations, and to find solutions for specific problem areas in runway incursion incidents.

Challenges and Opportunities for Integrating Social Science Perspectives into Climate and Global Change Assessments

NASA Astrophysics Data System (ADS)

Larson, E. K.; Li, J.; Zycherman, A.

2017-12-01

Integration of social science into climate and global change assessments is fundamental for improving understanding of the drivers, impacts and vulnerability of climate change, and the social, cultural and behavioral challenges related to climate change responses. This requires disciplinary and interdisciplinary knowledge as well as integrational and translational tools for linking this knowledge with the natural and physical sciences. The USGCRP's Social Science Coordinating Committee (SSCC) is tasked with this challenge and is working to integrate relevant social, economic and behavioral knowledge into processes like sustained assessments. This presentation will discuss outcomes from a recent SSCC workshop, "Social Science Perspectives on Climate Change" and their applications to sustained assessments. The workshop brought academic social scientists from four disciplines - anthropology, sociology, geography and archaeology - together with federal scientists and program managers to discuss three major research areas relevant to the USGCRP and climate assessments: (1) innovative tools, methods, and analyses to clarify the interactions of human and natural systems under climate change, (2) understanding of factors contributing to differences in social vulnerability between and within communities under climate change, and (3) social science perspectives on drivers of global climate change. These disciplines, collectively, emphasize the need to consider socio-cultural, political, economic, geographic, and historic factors, and their dynamic interactions, to understand climate change drivers, social vulnerability, and mitigation and adaptation responses. They also highlight the importance of mixed quantitative and qualitative methods to explain impacts, vulnerability, and responses at different time and spatial scales. This presentation will focus on major contributions of the social sciences to climate and global change research. We will discuss future directions for sustained assessments that integrate and reflect the social science understanding of the complex relationships between social and natural worlds in a changing climate, and factors that impact effective mitigation and adaptation strategies that address risks and vulnerabilities of climate change.

Potential effects on health of global warming

DOE Office of Scientific and Technical Information (OSTI.GOV)

Haines, A.; Parry, M.

1993-12-01

Prediction of the impacts of global climate change on health is complicated by a number of factors. These include: the difficulty in predicting regional changes in climate, the capacity for adaptation to climate change, the interactions between the effects of global climate change and a number of other key determinants of health, including population growth and poverty, and the availability of adequate preventive and curative facilities for diseases that may be effected by climate change. Nevertheless, it is of importance to consider the potential health impacts of global climate change for a number of reasons. It is also important tomore » monitor diseases which could be effected by climate change in order to detect changes in incidence as early as possible and study possible interactions with other factors. It seems likely that the possible impacts on health of climate change will be a major determinant of the degree to which policies aimed at reducing global warming are followed, as perceptions of the effect of climate change to human health and well-being are particularly likely to influence public opinion. The potential health impacts of climate change can be divided into direct (primary) and indirect (secondary and tertiary) effects. Primary effects are those related to the effect of temperature on human well-being and disease. Secondary effects include the impacts on health of changes in food production, availability of water and of sea level rise. A tertiary level of impacts can also be hypothesized.« less

Accounting for uncertainty in the quantification of the environmental impacts of Canadian pig farming systems.

PubMed

Mackenzie, S G; Leinonen, I; Ferguson, N; Kyriazakis, I

2015-06-01

The objective of the study was to develop a life cycle assessment (LCA) for pig farming systems that would account for uncertainty and variability in input data and allow systematic environmental impact comparisons between production systems. The environmental impacts of commercial pig production for 2 regions in Canada (Eastern and Western) were compared using a cradle-to-farm gate LCA. These systems had important contrasting characteristics such as typical feed ingredients used, herd performance, and expected emission factors from manure management. The study used detailed production data supplied by the industry and incorporated uncertainty/variation in all major aspects of the system including life cycle inventory data for feed ingredients, animal performance, energy inputs, and emission factors. The impacts were defined using 5 metrics-global warming potential, acidification potential, eutrophication potential (EP), abiotic resource use, and nonrenewable energy use-and were expressed per kilogram carcass weight at farm gate. Eutrophication potential was further separated into marine EP (MEP) and freshwater EP (FEP). Uncertainties in the model inputs were separated into 2 types: uncertainty in the data used to describe the system (α uncertainties) and uncertainty in impact calculations or background data that affects all systems equally (β uncertainties). The impacts of pig production in the 2 regions were systematically compared based on the differences in the systems (α uncertainties). The method of ascribing uncertainty influenced the outcomes. In eastern systems, EP, MEP, and FEP were lower (P < 0.05) when assuming that all uncertainty in the emission factors for leaching from manure application was β. This was mainly due to increased EP resulting from field emissions for typical ingredients in western diets. When uncertainty in these emission factors was assumed to be α, only FEP was lower in eastern systems (P < 0.05). The environmental impacts for the other impact categories were not significantly different between the 2 systems, despite their aforementioned differences. In conclusion, a probabilistic approach was used to develop an LCA that systematically dealt with uncertainty in the data when comparing multiple environmental impacts measures in pig farming systems for the first time. The method was used to identify differences between Canadian pig production systems but can also be applied for comparisons between other agricultural systems that include inherent variation.

Global patterns of drought recovery

DOE PAGES

Schwalm, Christopher R.; Anderegg, William R. L.; Michalak, Anna M.; ...

2017-08-09

Drought has major impacts on natural and human systems, and is especially important for land carbon sink variability due to its influence on terrestrial biosphere climate regulation. While 20th Century trends in drought regimes have been varied, “more extreme extremes”, including more frequent and severe droughts, are expected in the 21st Century. Recovery time, the length of time an ecosystem requires to revert to its pre-drought functional state, is a critical metric of drought impact. Yet the factors influencing drought recovery and its spatiotemporal patterns are largely unknown. Here we use three independent global data products of gross primary productivitymore » to show that, across diverse terrestrial ecosystems, drought recovery times are strongly associated with climate and carbon cycle dynamics, with biodiversity and CO 2 fertilization as secondary factors. Our analysis also provides two key insights into the spatiotemporal patterns of drought recovery time: (1) Across the globe, recovery is longest in the tropics and high northern latitudes—critical tipping elements in Earth’s climate system. (2) Drought impacts, the area of ecosystems under active recovery and recovery times, have increased over the 20th century. If future droughts become more frequent, time between droughts may become shorter than drought recovery time, leading to chronically impacted ecosystems.« less

Global patterns of drought recovery

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schwalm, Christopher R.; Anderegg, William R. L.; Michalak, Anna M.

Drought has major impacts on natural and human systems, and is especially important for land carbon sink variability due to its influence on terrestrial biosphere climate regulation. While 20th Century trends in drought regimes have been varied, “more extreme extremes”, including more frequent and severe droughts, are expected in the 21st Century. Recovery time, the length of time an ecosystem requires to revert to its pre-drought functional state, is a critical metric of drought impact. Yet the factors influencing drought recovery and its spatiotemporal patterns are largely unknown. Here we use three independent global data products of gross primary productivitymore » to show that, across diverse terrestrial ecosystems, drought recovery times are strongly associated with climate and carbon cycle dynamics, with biodiversity and CO 2 fertilization as secondary factors. Our analysis also provides two key insights into the spatiotemporal patterns of drought recovery time: (1) Across the globe, recovery is longest in the tropics and high northern latitudes—critical tipping elements in Earth’s climate system. (2) Drought impacts, the area of ecosystems under active recovery and recovery times, have increased over the 20th century. If future droughts become more frequent, time between droughts may become shorter than drought recovery time, leading to chronically impacted ecosystems.« less

A bibliometric analysis of digestive health research in Canada.

PubMed

Tuitt, Desiree; Knight, Frank; Lipman, Tara

2011-11-01

Measurement of the impact and influence of medical⁄scientific journals, and of individual researchers has become more widely practiced in recent decades. This is driven, in part, by the increased availability of data regarding citations of research articles, and by increased competition for research funding. Digestive disease research has been identified as a particularly strong discipline in Canada. The authors collected quantitative data on the impact and influence of Canadian digestive health research. The present study involved an analysis of the research impact (Hirsch factor) and research influence (Influence factor) of 106 digestive health researchers in Canada. Rankings of the top 25 researchers on the basis of the two metrics were dominated by the larger research groups at the University of Toronto (Toronto, Ontario), McMaster University (Hamilton, Ontario), and the Universities of Calgary (Calgary, Alberta) and Alberta (Edmonton, Alberta), but with representation by other research groups at the Universities of Manitoba (Winnipeg, Manitoba), Western Ontario (London, Ontario) and McGill University (Montreal, Quebec). Female and male researchers had similar scores for the two metrics, as did basic scientists versus clinical investigators. Strategic recruitment, particularly of established investigators, can have a major impact on the ranking of research groups. Comparing these metrics over different time frames can provide insights into the vulnerabilities and strengths of research groups.

Methods for evaluating riparian habitats with applications to management

USGS Publications Warehouse

Platts, William S.; Armour, C.L.; Booth, G.D.; Bryant, M.; Bufford, J.L.; Cuplin, P.; Jensen, S.; Lienkaemper, G.W.; Minshall, G.W.; Monsen, S.T.; Nelson, R.L.; Sedell, J.R.; Tuhy, J.S.

1987-01-01

Riparian area planning and management is a major national issues today--something that should have been the case a century ago. A century of additive effects of land use has resulted in major impacts on many riparian stream habitats and their fisheries, wildlife, and domestic livestock use. Before scientists can evaluate the influences of various land and water uses on riparian environments, they must first understand these environments. This means being able to detect and measure with confidence the natural and artificial variation and instantaneous conditions of the riparian habitat. These conditions must then be related to the production capability of riparian habitat and any extraneous factors affecting this production potential.

The Worst of Times, The Best of Times

PubMed Central

KARASU, T. BYRAM

1992-01-01

The author discusses the state of the art of psychotherapy at the brink of the new decade. The theme of the 1990s is rapprochement, the bridging of divisive aspects of the field. Four major manifestations of increased detente are explored: convergence of mind and brain, collaboration of research and public policy, coordination of economic constraints and ethical standards, and connection between psychopathology and therapeutic practice. Factors of major importance for the future of psychotherapy are the impact of the neurosciences on psychological phenomena, the role of the computer in human simulation, the socioeconomic influence of government and third-party payers on the direction of treatment, and the utilization of clinical practice in devising new diagnostic dimensions. PMID:22700051

Exploring community gardens in a health disparate population: findings from a mixed methods pilot study.

PubMed

Zoellner, Jamie; Zanko, Ashley; Price, Bryan; Bonner, Jennifer; Hill, Jennie L

2012-01-01

Despite recommendations, there have been few efforts to apply the community-based participatory research (CBPR) approach in the development, implementation, and evaluation of community gardens. As guided by the CBPR approach and grounded in a social-ecological model and behavioral theory, the purpose of this mixed methods study was to understand opinions and interests in developing and implementing a community garden and to understand factors impacting fruit, vegetable, and gardening behaviors. Community and academic members collaborated to develop and execute this study. The qualitative phase- targeting regional key informants-was designed to elicit perceived benefits and challenges of community gardens at the environmental, community, and individual levels. The quantitative phase targeted low resourced youth and parents and included a variety of validated theory-based questionnaires to understand factors impacting fruit, vegetable, and gardening behaviors. Major benefits of community gardens that emerged from the 10 qualitative interviews included increasing community cohesion and improving nutrition and physical activity factors. The quantitative phase included 87 youth and 67 parents. Across 16 items for fruits and vegetables, the average willingness to try was 1.32 (standard deviation [SD] = 0.40) on a 2-point scale. The majority of youth indicated they would work in a garden (n = 59; 68%) and eat food grown in their garden (n = 71; 82%). Among parents, gardening attitude, belief, and self-efficacy scores were all above average; however, gardening intentions were neutral. This research illustrates the successful partnering a community-academic team and has provided the partnership with a clearer lens to conceptualize and launch future regional community garden efforts.

The Future of Basic Science in Academic Surgery: Identifying Barriers to Success for Surgeon-scientists.

PubMed

Keswani, Sundeep G; Moles, Chad M; Morowitz, Michael; Zeh, Herbert; Kuo, John S; Levine, Matthew H; Cheng, Lily S; Hackam, David J; Ahuja, Nita; Goldstein, Allan M

2017-06-01

The aim of this study was to examine the challenges confronting surgeons performing basic science research in today's academic surgery environment. Multiple studies have identified challenges confronting surgeon-scientists and impacting their ability to be successful. Although these threats have been known for decades, the downward trend in the number of successful surgeon-scientists continues. Clinical demands, funding challenges, and other factors play important roles, but a rigorous analysis of academic surgeons and their experiences regarding these issues has not previously been performed. An online survey was distributed to 2504 members of the Association for Academic Surgery and Society of University Surgeons to determine factors impacting success. Survey results were subjected to statistical analyses. We also reviewed publicly available data regarding funding from the National Institutes of Health (NIH). NIH data revealed a 27% decline in the proportion of NIH funding to surgical departments relative to total NIH funding from 2007 to 2014. A total of 1033 (41%) members responded to our survey, making this the largest survey of academic surgeons to date. Surgeons most often cited the following factors as major impediments to pursuing basic investigation: pressure to be clinically productive, excessive administrative responsibilities, difficulty obtaining extramural funding, and desire for work-life balance. Surprisingly, a majority (68%) did not believe surgeons can be successful basic scientists in today's environment, including departmental leadership. We have identified important barriers that confront academic surgeons pursuing basic research and a perception that success in basic science may no longer be achievable. These barriers need to be addressed to ensure the continued development of future surgeon-scientists.

Sepsis risk factors in infants with congenital diaphragmatic hernia.

PubMed

Levy, Michaël; Le Sache, Nolwenn; Mokhtari, Mostafa; Fagherazzi, Guy; Cuzon, Gaelle; Bueno, Benjamin; Fouquet, Virginie; Benachi, Alexandra; Eleni Dit Trolli, Sergio; Tissieres, Pierre

2017-12-01

Congenital diaphragmatic hernia (CDH) is a rare congenital anomaly and remains among the most challenging ICU-managed disease. Beside severe pulmonary hypertension, lung hypoplasia and major abdominal surgery, infective complications remain major determinants of outcome. However, the specific incidence of sepsis as well as associated risk factors is unknown. This prospective, 4-year observational study took place in the pediatric intensive care and neonatal medicine department of the Paris South University Hospitals (Le Kremlin-Bicêtre, France), CDH national referral center and involved 62 neonates with CDH. During their ICU stay, 28 patients (45%) developed 38 sepsis episodes. Ventilator-associated pneumonia (VAP: 23/38; 31.9 VAP per 1000 days of mechanical ventilation) and central line-associated blood stream infections (CLABSI: 5/38; 5.5 per 1000 line days) were the most frequently encountered infections. Multivariate analysis showed that gestational age at birth and intra-thoracic position of liver were significantly associated with the occurrence of sepsis. Infected patients had longer duration of mechanical and noninvasive ventilation (16.2 and 5.8 days, respectively), longer delay to first feeding (1.2 days) and a longer length of stay in ICU (23 days), but there was no difference in mortality. Healthcare-associated infections, and more specifically VAP, are the main infective threat in children with CDH. Sepsis has a significant impact on the duration of ventilator support and ICU length of stay but does not impact mortality. Low gestational age and intra-thoracic localization of the liver are two independent risk factors associated with sepsis.

Stereotype threat's effect on women's achievement in chemistry: The interaction of achievement goal orientation for women in science majors

NASA Astrophysics Data System (ADS)

Conway-Klaassen, Janice Marjorie

"Stereotype threat is being at risk of confirming, as a self-characteristic, a negative stereotype about one's group" (C. M. Steele & Aronson, 1995, p. 797). A stereotype threat effect then is described as the detrimental impact on a person's performance or achievement measurements when they are placed in a stereotype threat environment. For women, the negative stereotype that exists in our culture states that women are typically not as capable as men in mathematics or science subjects. This study specifically explored the potential impact of stereotype threat on women who have chosen a science-based college major. They were tested in the domain of chemistry, which is related to mathematics and often involves high level of mathematics skills. I attempted to generate a stereotype threat in the participants through describing a chemistry challenge exam as either one that had consistently shown a gender bias against women and to create a nullification effect by describing the exam as one that had shown no gender bias in the past. In the third experimental condition acting as a control, participants received only generic instructions related to taking the test itself. The second part of this study investigated whether stereotype threat effects could impact women's achievement goal orientations. In previous studies performance avoidance goal orientations have been associated with individuals placed in a stereotype threat environment. The findings on the stereotype threat effect were not significant for the chemistry challenge test achievement scores. This may be due to several factors. One factor may be the design of the chemistry challenge test and the instructions for the test. The other factor may be the women in this study. As individuals who have chosen a science based major, they may have developed coping skills and strategies that reduced the impact of a stereotype threat. It is also possible that the testing environment itself generated an implicit stereotype type threat effect which reduced the differences among the experimental conditions. However, there were significant findings related to the participants' achievement goal orientations. Individuals in the stereotype threat condition displayed higher levels of performance avoidance, overall performance, and overall avoidance goal orientations consistent with the existing literature. Post-hoc open-ended questionnaires revealed that most participants believed that men and women were equally capable in mathematics and sciences but that they also had an awareness of the negative stereotype against women in mathematics and sciences among the public. This study supports the demonstration of stereotype threat effects on women who are enrolled in science based college majors. Although I was not able to create a stereotype threat effect on their chemistry challenge test scores, I was able to demonstrate an effect on their achievement goal orientations, which has implications for instructional design and standardized testing.

External biliary drainage following major liver resection for perihilar cholangiocarcinoma: impact on development of liver failure and biliary leakage

PubMed Central

Olthof, Pim B.; Coelen, Robert J.S.; Wiggers, Jimme K.; Besselink, Marc G.H.; Busch, Olivier R.C.; van Gulik, Thomas M.

2016-01-01

Background Preoperative biliary drainage is considered essential in perihilar cholangiocarcinoma (PHC) requiring major hepatectomy with biliary-enteric reconstruction. However, evidence for postoperative biliary drainage as to protect the anastomosis is currently lacking. This study investigated the impact of postoperative external biliary drainage on the development of post-hepatectomy biliary leakage and liver failure (PHLF). Methods All patients who underwent major liver resection for suspected PHC between 2000 and 2015 were retrospectively analyzed. Biliary leakage and PHLF was defined as grade B or higher according to the International Study Group of Liver Surgery (ISGLS) criteria. Results Eighty-nine out of 125 (71%) patients had postoperative external biliary drainage. PHLF was more prevalent in the drain group (29% versus 6%; P = 0.004). There was no difference in the incidence of biliary leakage (32% versus 36%). On multivariable analysis, postoperative external biliary drainage was identified as an independent risk factor for PHLF (Odds-ratio 10.3, 95% confidence interval 2.1–50.4; P = 0.004). Conclusions External biliary drainage following major hepatectomy for PHC was associated with an increased incidence of PHLF. It is therefore not recommended to routinely use postoperative external biliary drainage, especially as there is no evidence that this decreases the risk of biliary anastomotic leakage. PMID:27037204

Glycans as Regulatory Elements of the Insulin/IGF System: Impact in Cancer Progression

PubMed Central

Andrade-da-Costa, Jéssica; Silva, Mariana Costa

2017-01-01

The insulin/insulin-like growth factor (IGF) system in mammals comprises a dynamic network of proteins that modulate several biological processes such as development, cell growth, metabolism, and aging. Dysregulation of the insulin/IGF system has major implications for several pathological conditions such as diabetes and cancer. Metabolic changes also culminate in aberrant glycosylation, which has been highlighted as a hallmark of cancer. Changes in glycosylation regulate every pathophysiological step of cancer progression including tumour cell-cell dissociation, cell migration, cell signaling and metastasis. This review discusses how the insulin/IGF system integrates with glycosylation alterations and impacts on cell behaviour, metabolism and drug resistance in cancer. PMID:28880250

Female Pattern Hair Loss: a clinical and pathophysiological review*

PubMed Central

Ramos, Paulo Müller; Miot, Hélio Amante

2015-01-01

Female Pattern Hair Loss or female androgenetic alopecia is the main cause of hair loss in adult women and has a major impact on patients' quality of life. It evolves from the progressive miniaturization of follicles that lead to a subsequent decrease of the hair density, leading to a non-scarring diffuse alopecia, with characteristic clinical, dermoscopic and histological patterns. In spite of the high frequency of the disease and the relevance of its psychological impact, its pathogenesis is not yet fully understood, being influenced by genetic, hormonal and environmental factors. In addition, response to treatment is variable. In this article, authors discuss the main clinical, epidemiological and pathophysiological aspects of female pattern hair loss. PMID:26375223

Epigenetic Mechanisms Impacting Aging: A Focus on Histone Levels and Telomeres

PubMed Central

Song, Shufei

2018-01-01

Aging and age-related diseases pose some of the most significant and difficult challenges to modern society as well as to the scientific and medical communities. Biological aging is a complex, and, under normal circumstances, seemingly irreversible collection of processes that involves numerous underlying mechanisms. Among these, chromatin-based processes have emerged as major regulators of cellular and organismal aging. These include DNA methylation, histone modifications, nucleosome positioning, and telomere regulation, including how these are influenced by environmental factors such as diet. Here we focus on two interconnected categories of chromatin-based mechanisms impacting aging: those involving changes in the levels of histones or in the functions of telomeres. PMID:29642537

The impact of cotton growing practices on soil microbiology and its relation to plant and soil health

NASA Astrophysics Data System (ADS)

Pereg, Lily

2013-04-01

Crop production and agricultural practices heavily impact the soil microbial communities, which differ among varying types of soils and environmental conditions. Soil-borne microbial communities in cotton production systems, as in every other cropping system, consist of microbial populations that may either be pathogenic, beneficial or neutral with respect to the cotton crop. Crop production practices have major roles in determining the composition of microbial communities and function of microbial populations in soils. The structure and function of any given microbial community is determined by various factors, including those that are influenced by farming and those not controlled by farming activities. Examples of the latter are environmental conditions such as soil type, temperature, daylight length and UV radiation, air humidity, atmospheric pressure and some abiotic features of the soil. On the other hand, crop production practices may determine other abiotic soil properties, such as water content, density, oxygen levels, mineral and elemental nutrient levels and the load of other crop-related soil amendments. Moreover, crop production highly influences the biotic properties of the soil and has a major role in determining the fate of soil-borne microbial communities associated with the crop plant. Various microbial strains react differently to the presence of certain plants and plant exudates. Therefore, the type of plant and crop rotations are important factors determining microbial communities. In addition, practice management, e.g. soil cultivation versus crop stubble retention, have a major effect on the soil conditions and, thus, on microbial community structure and function. All of the above-mentioned factors can lead to preferential selection of certain microbial population over others. It may affect not only the composition of microbial communities (diversity and abundance of microbial members) but also the function of the community (the ability of different microbes to perform certain activities). Therefore, agricultural practices may determine the ability of beneficial microbes to realise their plant growth promoting potential or the pathogenic expression of others. This presentation will review the current knowledge about the impact of cotton growing practices on microbial communities and soil health in different environments as well as endeavour to identify gaps worthwhile exploring in future research for promoting plant growth in healthy soils.

Suicide Reporting on Front Pages of Major Newspapers in Taiwan Violating Reporting Recommendations Between 2001 and 2012.

PubMed

Chiang, Yi-Chen; Chung, Fung-Yu; Lee, Chun-Yang; Shih, Huei-Lin; Lin, Dai-Chan; Lee, Ming-Been

2016-11-01

Media reporting can lead to the acceptance of incorrect ideas and information by the general public, which in turn can impact behavior. A number of studies have found that suicide reporting in the media can lead to an increase in the suicide rate or copycat suicides. Therefore, the aims of this study are to (a) investigate front-page reporting of suicide in four major newspapers in Taiwan; (b) investigate violation of recommendations for reporting suicide by the four major newspapers in Taiwan; and (c) investigate the impact of important events and government policy on front-page reporting of suicide (i.e., the effect of the Apple Daily newspaper entering the market, and the start of media monitoring). We carried out content analysis of reports of suicide on the front pages of the four newspapers with the highest rates of readership in Taiwan (China Times, Liberty Times, Apple Daily, and United Daily News) between 2001 and 2012. We used the chi-squared test, chi-squared test for trend, and analysis of variance to analyze trends in violation of reporting recommendations and potential associated factors. We found that (a) suicide was most commonly reported as a front-page headline and as a whole-page spread by the four major newspapers in Taiwan, with many reports including photographs; (b) reporting of suicide by the four major newspapers in Taiwan frequently violated World Health Organization (WHO) recommendations for suicide reporting in the media; (c) following the entry of the Apple Daily newspaper into the Taiwanese market, reporting approaches to suicide by the other three major newspapers changed to more sensational photos and texts; and (d) monitoring of suicide reporting by the Taiwan Suicide Prevention Center appears to have been only partially effective. In summary, reporting of suicide by the four major newspapers in Taiwan could be further improved. Effective regulation of suicide reporting by newspapers could reduce the impact of this reporting on readers. In addition, regular assessment of observance of the WHO recommendations for suicide reporting by newspapers is an important part of suicide prevention.

The impact and determinants of the energy paradigm on economic growth in European Union.

PubMed

Andrei, Jean Vasile; Mieila, Mihai; Panait, Mirela

2017-01-01

Contemporary economies are strongly reliant on energy and analyzing the determining factors that trigger the changes in energy paradigm and their impact upon economic growth is a topical research subject. Our contention is that energy paradigm plays a major role in achieving the sustainable development of contemporary economies. In order to prove this the panel data methodology of research was employed, namely four panel unit root tests (LLC, IPS, F-ADF and F-PP) aiming to reveal the connections and relevance among 17 variables denoting energy influence on economic development. Moreover, it was introduced a specific indicator to express energy consumption per capita. Our findings extend the classical approach of the changes in energy paradigm and their impact upon economic growth and offer a comprehensive analysis which surpasses the practices and policy decisions in the field.

Emergency department overcrowding: the impact of resource scarcity on physician job satisfaction.

PubMed

Rondeau, Kent V; Francescutti, Louis H

2005-01-01

Emergency departments in most developed countries have been experiencing significant overcrowding under a regime of severe resource constraints. Physicians in emergency departments increasingly find themselves toiling in workplaces that are characterized by diminished availability of, limited access to, and decreased stability of critical resources. Severe resource constraints have the potential to greatly weaken the overall job satisfaction of emergency physicians. This article examines the impact of hospital resource constraints on the job satisfaction of a large sample of emergency physicians in Canada. After controlling for workflow and patient characteristics and for various institutional and physician characteristics, institutional resource constraints are found to be major contributors to emergency physician job dissatisfaction. Resource factors that have the greatest impact on job satisfaction include availability of emergency room physicians, access to hospital technology and emergency beds, and stability of financial (investment) resources.

Reflections on a boom: Perceptions of energy development impacts in the Bakken oil patch inform environmental science & policy priorities.

PubMed

McGranahan, Devan Allen; Fernando, Felix N; Kirkwood, Meghan L E

2017-12-01

Ecosystems worldwide have been subject to new or intensified energy development facilitated by technologies such as horizontal drilling and hydraulic fracturing, activity that has generated concern for air, water, biotic, and social resources. Application of these technologies in the development of the Bakken oil patch has made it one of the most productive petroleum plays in North America, causing unprecedented landscape industrialization of otherwise rural, agricultural counties in western North Dakota. The region is isolated, and development impacts have not been well-studied. To identify concerns of citizens of the Bakken and determine how research and policy might support them, we conducted a two-part study: First, we held focus groups with resource management and community leaders in three major oil-producing counties. Second, we used an outline of the major concerns expressed by focus group members as a survey for landowners and farm/ranch operators. We found little relationship between survey respondents' reported categorization of energy impacts and actual land area impacted, suggesting factors such as attitude towards development, degree of compensation, and level of disturbance are relevant. Landowners agreed with focus groups on the nature of relationships between energy companies and locals and development impacts on infrastructure and communities; those reporting greater impacts tended to agree more strongly. But many specific problems described in focus groups were not widely reported in the survey, suggesting energy-community relationships can be improved through state-level public policy and respect from energy companies for locals and their way of life. Consideration of these concerns in future energy policy-both in the Bakken and worldwide-could reduce social tension, lessen environmental impact, and increase overall social, economic, and environmental efficiency in energy development. Copyright © 2017 Elsevier B.V. All rights reserved.

Towards a meaningful assessment of marine ecological impacts in life cycle assessment (LCA).

PubMed

Woods, John S; Veltman, Karin; Huijbregts, Mark A J; Verones, Francesca; Hertwich, Edgar G

2016-01-01

Human demands on marine resources and space are currently unprecedented and concerns are rising over observed declines in marine biodiversity. A quantitative understanding of the impact of industrial activities on the marine environment is thus essential. Life cycle assessment (LCA) is a widely applied method for quantifying the environmental impact of products and processes. LCA was originally developed to assess the impacts of land-based industries on mainly terrestrial and freshwater ecosystems. As such, impact indicators for major drivers of marine biodiversity loss are currently lacking. We review quantitative approaches for cause-effect assessment of seven major drivers of marine biodiversity loss: climate change, ocean acidification, eutrophication-induced hypoxia, seabed damage, overexploitation of biotic resources, invasive species and marine plastic debris. Our review shows that impact indicators can be developed for all identified drivers, albeit at different levels of coverage of cause-effect pathways and variable levels of uncertainty and spatial coverage. Modeling approaches to predict the spatial distribution and intensity of human-driven interventions in the marine environment are relatively well-established and can be employed to develop spatially-explicit LCA fate factors. Modeling approaches to quantify the effects of these interventions on marine biodiversity are less well-developed. We highlight specific research challenges to facilitate a coherent incorporation of marine biodiversity loss in LCA, thereby making LCA a more comprehensive and robust environmental impact assessment tool. Research challenges of particular importance include i) incorporation of the non-linear behavior of global circulation models (GCMs) within an LCA framework and ii) improving spatial differentiation, especially the representation of coastal regions in GCMs and ocean-carbon cycle models. Copyright © 2016 Elsevier Ltd. All rights reserved.

Massive horizontal transfer of transposable elements in insects

PubMed Central

Peccoud, Jean; Loiseau, Vincent; Cordaux, Richard

2017-01-01

Horizontal transfer (HT) of genetic material is central to the architecture and evolution of prokaryote genomes. Within eukaryotes, the majority of HTs reported so far are transfers of transposable elements (TEs). These reports essentially come from studies focusing on specific lineages or types of TEs. Because of the lack of large-scale survey, the amount and impact of HT of TEs (HTT) in eukaryote evolution, as well as the trends and factors shaping these transfers, are poorly known. Here, we report a comprehensive analysis of HTT in 195 insect genomes, representing 123 genera and 13 of the 28 insect orders. We found that these insects were involved in at least 2,248 HTT events that essentially occurred during the last 10 My. We show that DNA transposons transfer horizontally more often than retrotransposons, and unveil phylogenetic relatedness and geographical proximity as major factors facilitating HTT in insects. Even though our study is restricted to a small fraction of insect biodiversity and to a recent evolutionary timeframe, the TEs we found to be horizontally transferred generated up to 24% (2.08% on average) of all nucleotides of insect genomes. Together, our results establish HTT as a major force shaping insect genome evolution. PMID:28416702

Management of radon: a review of ICRP recommendations.

PubMed

Vaillant, Ludovic; Bataille, Céline

2012-09-01

This article proposes a review of past and current ICRP publications dealing with the management of radon exposures. Its main objective is to identify and discuss the driving factors that have been used by the Commission during the last 50 years so as to better appreciate current issues regarding radon exposure management. The analysis shows that major evolutions took place in very recent years. As far as the management of radon exposures is concerned, ICRP recommended, until ICRP Publication 103 (ICRP 2007 ICRP Publication 103; Ann. ICRP 37), to use action levels and to consider only exposures above these levels. The Commission has reviewed its approach and now proposes to manage any radon exposure through the application of the optimisation principle and associated reference levels. As far as the assessment of the radon risk is concerned, it appears that the successive changes made by ICRP did not have a strong impact on the values of radon gas concentration recommended as action levels either in dwellings or in workplaces. The major change occurred in late 2009 with the publication of the ICRP Statement on Radon, which acknowledged that the radon risk has been underestimated by a factor of 2, thus inducing a major revision of radon reference levels.

Using EEG to Discriminate Cognitive Workload and Performance Based on Neural Activation and Connectivity

DTIC Science & Technology

2016-05-31

auditory working memory task to vary cognitive workload by altering the number of digits held in memory during the simultaneous retention of a sentence...in memory . Cognitive efficacy is assessed based on accuracy in recalling digits from memory . A Gaussian classifier is used to discriminate cognitive...effectiveness of cognition under the existing load. One major factor that impacts cognitive load is the amount of working memory required in a task

Nitrogen Dioxide pollution and hazardous household environment: what impacts more congenital malformations.

PubMed

Landau, D; Novack, L; Yitshak-Sade, M; Sarov, B; Kloog, I; Hershkovitz, R; Grotto, I; Karakis, I

2015-11-01

Nitrogen Dioxide (NO2) is a product of fuel combustion originating mainly from industry and transportation. Studies suggest an association between NO2 and congenital malformations (CM). We investigated an independent effect of NO2 on CM by adjusting to individual factors and household environment in 1024 Bedouin-Arab pregnant women in southern Israel. This population is characterised by high rates of CMs, frequent consanguineous marriages, paternal smoking, temporary housing and usage of open fire for heat cooking. Information on household risk factors was collected during an interview. Ambient measurements of 24-h average NO2 and meteorological conditions were obtained from 13 local monitors. Median value of daily NO2 measured in the area was 6.78ppb. CM was diagnosed in 8.0% (82) of offspring. Maternal NO2 exposure during the 1st trimester >8.6ppb was significantly associated with minor CM (RR=2.68, p=0.029). Major CM were independently associated with maternal juvenile diabetes (RR=9.97, p-value=0.002) and heating by open fire (RR=2.00, p-value=0.049), but not NO2 exposure. We found that NO2 emissions had an independent impact only on minor malformations, whereas major malformations depended mostly on the household environment. Antepartum deaths were associated by maternal morbidity. Copyright © 2015 Elsevier Ltd. All rights reserved.

Cultural context of school communities in rural Hawaii to inform youth violence prevention.

PubMed

Affonso, Dyanne D; Mayberry, Linda; Shibuya, June Y; Archambeau, Olga G; Correa, Mary; Deliramich, Aimee N; Frueh, B Christopher

2010-03-01

Escalation of youth violence within a large geographic school-complex area in southeastern rural Hawaii became a major problem in 2006. How cultural forces impact the problem was an impetus to examine youth violence from perspectives of adults and children in rural communities. Gathering these data was an essential first step toward school-based youth violence prevention program development. Eight focus groups involving 86 community stakeholders included 51 adults (parent, teachers, school staff, community leaders) and 35 children aged 8-15 years old (3rd- to 10-th grade). Qualitative narrative analysis elicited major themes. Five themes emerged: (1) School-community violence takes on many forms that become entrenched in local culture. (2) Disintegration of community resources and a sense of learned helplessness underlie the escalation of youth violence. (3) Inadequate role modeling coupled with behavioral ambivalence among adults has sustained a climate of local cultural acceptance with youth violence. (4) Connection to cultural values has diminished, leading to a sense of loss in cultural identity among students. (5) Cultural values and practices are potential strategies for youth violence prevention. Cultural and community contextual factors contributed to youth violence in rural Hawaiian communities. Study implications include the need to further investigate the impact of vigilant, community involvement of stakeholders in school-based youth violence prevention program development. Cultural revitalization at family, school, and community levels may be critical success factors of such programs.

Impact of Various Biofuel Feedstock Production Scenarios on Water Quality in the Upper Mississippi River Basin

NASA Astrophysics Data System (ADS)

Wu, M.; Demissie, Y.; Yan, E.

2010-12-01

The impact of increased biofuel feedstock production on regional water quality was examined. This study focused on the Upper Mississippi River Basin, from which a majority of U.S. biofuel is currently produced. The production of biofuel from both conventional feedstock and cellulosic feedstock will potentially increase in the near future. Historically, this water basin generates the largest nitrogen loading to the waterway in the United States and is often cited as a main contributor to the anoxic zone in the Gulf of Mexico. To obtain a quantitative and spatial estimate of nutrient burdens at the river basin, a SWAT (Soil and Water Assessment Tool) model application was developed. The model was equipped with an updated nutrient cycle feature and modified model parameters to represent current crop and perennial grass yield as a result of advancements in breeding and biotechnology. Various biofuel feedstock production scenarios were developed to assess the potential environmental implications of increased biofuel production through corn, agriculture residue, and perennial cellulosic feedstock (such as Switchgrass). Major factors were analyzed, including land use changes, feedstock types, fertilizer inputs, soil property, and yield. This tool can be used to identify specific regional factors affecting water quality and examine options to meet the requirement for environmental sustainability, thereby mitigating undesirable environmental consequences while strengthening energy security.

Distribution of scholarly publications among academic radiology departments.

PubMed

Morelli, John N; Bokhari, Danial

2013-03-01

The aim of this study was to determine whether the distribution of publications among academic radiology departments in the United States is Gaussian (ie, the bell curve) or Paretian. The search affiliation feature of the PubMed database was used to search for publications in 3 general radiology journals with high Impact Factors, originating at radiology departments in the United States affiliated with residency training programs. The distribution of the number of publications among departments was examined using χ(2) test statistics to determine whether it followed a Pareto or a Gaussian distribution more closely. A total of 14,219 publications contributed since 1987 by faculty members in 163 departments with residency programs were available for assessment. The data acquired were more consistent with a Pareto (χ(2) = 80.4) than a Gaussian (χ(2) = 659.5) distribution. The mean number of publications for departments was 79.9 ± 146 (range, 0-943). The median number of publications was 16.5. The majority (>50%) of major radiology publications from academic departments with residency programs originated in <10% (n = 15 of 178) of such departments. Fifteen programs likewise produced no publications in the surveyed journals. The number of publications in journals with high Impact Factors published by academic radiology departments more closely fits a Pareto rather than a normal distribution. Copyright © 2013 American College of Radiology. Published by Elsevier Inc. All rights reserved.

Cardiovascular diseases and diabetes as economic and developmental challenges in Africa.

PubMed

Kengne, Andre Pascal; June-Rose McHiza, Zandile; Amoah, Albert George Baidoe; Mbanya, Jean-Claude

2013-01-01

Current estimates and projections suggest that the burden of cardiovascular diseases (CVDs), diabetes and related risk factors in African countries is important, somewhat unique and rapidly growing. Various segments of the population are affected; however, the group mostly affected is young adults residing in urban areas, and increasingly those in the low socioeconomic strata. The African milieu/environment is compounded by weak health systems, which are unable to cope with the looming double burden of communicable and chronic non-communicable diseases. This review discusses the economic and developmental challenges posed by CVDs and diabetes in countries in Africa. Using several lines of evidence, we demonstrate that the cost of care for major CVDs and diabetes is beyond the coping capacities of individuals, households, families and governments in most African countries. We have reviewed modeling studies by the International Diabetes Federation (IDF) and other major international agencies on the current and projected impact that CVDs and diabetes have on the economy and development of countries in the region. Locally, appropriate strategies to limit the impact of the conditions on the economies and development of countries in Africa are suggested and discussed. These include monitoring diseases and risk factors, and primordial, primary and secondary preventions implemented following a life-course perspective. Structural, logistic, human capacity and organizational challenges to be surmounted during the implementations of these strategies will be reviewed. © 2013.

Gene-environment interaction in major depression: focus on experience-dependent biological systems.

PubMed

Lopizzo, Nicola; Bocchio Chiavetto, Luisella; Cattane, Nadia; Plazzotta, Giona; Tarazi, Frank I; Pariante, Carmine M; Riva, Marco A; Cattaneo, Annamaria

2015-01-01

Major depressive disorder (MDD) is a multifactorial and polygenic disorder, where multiple and partially overlapping sets of susceptibility genes interact each other and with the environment, predisposing individuals to the development of the illness. Thus, MDD results from a complex interplay of vulnerability genes and environmental factors that act cumulatively throughout individual's lifetime. Among these environmental factors, stressful life experiences, especially those occurring early in life, have been suggested to exert a crucial impact on brain development, leading to permanent functional changes that may contribute to lifelong risk for mental health outcomes. In this review, we will discuss how genetic variants (polymorphisms, SNPs) within genes operating in neurobiological systems that mediate stress response and synaptic plasticity, can impact, by themselves, the vulnerability risk for MDD; we will also consider how this MDD risk can be further modulated when gene × environment interaction is taken into account. Finally, we will discuss the role of epigenetic mechanisms, and in particular of DNA methylation and miRNAs expression changes, in mediating the effect of the stress on the vulnerability risk to develop MDD. Taken together, we aim to underlie the role of genetic and epigenetic processes involved in stress- and neuroplasticity-related biological systems on the development of MDD after exposure to early life stress, thereby building the basis for future research and clinical interventions.

Optimization of Driving Styles for Fuel Economy Improvement

DOE Office of Scientific and Technical Information (OSTI.GOV)

Malikopoulos, Andreas; Aguilar, Juan P.

2012-01-01

Modern vehicles have sophisticated electronic control units, particularly to control engine operation with respect to a balance between fuel economy, emissions, and power. These control units are designed for specific driving conditions and testing. However, each individual driving style is different and rarely meets those driving conditions. In the research reported here we investigate those driving style factors that have a major impact on fuel economy. An optimization framework is proposed with the aim of optimizing driving styles with respect to these driving factors. A set of polynomial metamodels are constructed to reflect the responses produced by changes of themore » driving factors. Then we compare the optimized driving styles to the original ones and evaluate the efficiency and effectiveness of the optimization formulation.« less

Assessing the differences in public health impact of salmonella subtypes using a bayesian microbial subtyping approach for source attribution.

PubMed

Pires, Sara M; Hald, Tine

2010-02-01

Salmonella is a major cause of human gastroenteritis worldwide. To prioritize interventions and assess the effectiveness of efforts to reduce illness, it is important to attribute salmonellosis to the responsible sources. Studies have suggested that some Salmonella subtypes have a higher health impact than others. Likewise, some food sources appear to have a higher impact than others. Knowledge of variability in the impact of subtypes and sources may provide valuable added information for research, risk management, and public health strategies. We developed a Bayesian model that attributes illness to specific sources and allows for a better estimation of the differences in the ability of Salmonella subtypes and food types to result in reported salmonellosis. The model accommodates data for multiple years and is based on the Danish Salmonella surveillance. The number of sporadic cases caused by different Salmonella subtypes is estimated as a function of the prevalence of these subtypes in the animal-food sources, the amount of food consumed, subtype-related factors, and source-related factors. Our results showed relative differences between Salmonella subtypes in their ability to cause disease. These differences presumably represent multiple factors, such as differences in survivability through the food chain and/or pathogenicity. The relative importance of the source-dependent factors varied considerably over the years, reflecting, among others, variability in the surveillance programs for the different animal sources. The presented model requires estimation of fewer parameters than a previously developed model, and thus allows for a better estimation of these factors to result in reported human disease. In addition, a comparison of the results of the same model using different sets of typing data revealed that the model can be applied to data with less discriminatory power, which is the only data available in many countries. In conclusion, the model allows for the estimation of relative differences between Salmonella subtypes and sources, providing results that will benefit future risk assessment or risk ranking purposes.

On the Influence of Anthropogenic Forcings on Changes in the Stratospheric Mean Age

NASA Technical Reports Server (NTRS)

Oman, Luke; Waugh, Darryn W.; Pawson, Steven; Stolarski, Richard S.; Newman, Paul A.

2009-01-01

A common feature of stratospheric simulations of the past or future is an increase in tropical upwelling and a decrease in mean age. Possible causes or these changes include (1) increases in tropical sea surface temperatures (SSTs) driven by increases in well-mixed greenhouse gases (WMGHGs), (2) the direct radiative effect of increases in WMGHGs, and (3) changes in ozone. Here we examine a suite of simulations from the Goddard Earth Observing System chemistry-climate model (GEOS CCM) to isolate the relative role of these three factors. Our analysis indicates that all three factors cause changes in the mean age, but the relative impact of each factor depends on the time period analyzed. Over the past 30-40 years ozone depletion is the major factor causing the decrease in mean age, with negligible changes due to direct radiative impact of WMGHG's. However, ozone is predicted to recover back to 1970 levels during the next 50-60 years, and this causes an increase in the mean age, whereas the continued increase in SSTs from increased levels of WMGHGs and the direct radiative impact of WMGHGs will still cause a decrease in the mean age. The net impact of these factors will still result in a decreasing mean age although the rate will be smaller than that of the past. The decreases in mean age are primarily caused by increases in upwelling in the tropical lower stratosphere. The increased upwelling from both increased tropical SSTs and polar ozone loss appears to be related to changes in zonal winds and increases in wave activity propagating into the stratosphere. The different contributions of changes in SSTs, WMGHGs, and ozone to the circulation of the stratosphere may help explain the large spread in the rate of change of tropical upwelling seen in previous studies.

[The impact of the annual scientific meetings of the Israel Society of Rheumatology as measured by publication rates of the abstracts in peer-reviewed journals].

PubMed

Perez, Shira; Hashkes, Philip J; Uziel, Yosef

2004-04-01

We aimed to examine the impact and quality of the research presented in the Israel Society of Rheumatology (ISR) annual scientific meetings by measuring publication rates of the abstracts in peer-reviewed journals and investigating the factors that influenced publication. We examined the outcome of all 79 abstracts submitted to the ISR for the 1998-2000 annual meetings. A MEDLINE search of all abstracts, by authors, topics and keywords was performed. Senior authors of abstracts not found to be published in this search were interviewed regarding publication and factors influencing submission. We described the effect of variable factors on the rate of publication. As of September 2002, 63 (80%) abstracts were published in peer-reviewed journals or are currently in-press. Most abstracts were published in prominent journals (with a high impact factor). The majority of the abstracts (61%) were published in rheumatologic journals, 65% of the studies originated from tertiary centers and 19% of the studies were multicenter. The most common diseases studied were antiphospholipid syndrome (20%), systemic lupus erythematosus (19%) and inflammatory arthritis (18%). Most of the studies were of disease pathogenesis (35%) and clinical manifestations (33%). The most common study designs were basic science (34%). An overall 57% of the studies reported "positive" results and 9% reported "negative" results. None of the factors studied were associated with publication or non-publication. The main cause cited by authors for not publishing their abstract was lack of time to prepare a full paper or a desire to further expand the study. Within this group of 16 authors of abstracts, 11 authors still plan to submit a paper. The ISR annual meetings have an important clinical scientific impact as measured by the high rate of abstracts published as full length articles in leading peer-reviewed journals.

Key factors of low carbon development strategy for sustainable transport

NASA Astrophysics Data System (ADS)

Thaveewatanaseth, K.; Limjirakan, S.

2018-02-01

Cities become more vulnerable to climate change impacts causing by urbanization, economic growth, increasing of energy consumption and carbon dioxide (CO2) emissions. People who live in the cities have already been affected from the impacts in terms of socioeconomic and environmental aspects. Sustainable transport plays the key role in CO2 mitigation and contributes positive impacts on sustainable development for the cities. Several studies in megacities both in developed and developing countries support that mass transit system is an important transportation mode in CO2 mitigation and sustainable transport development. This paper aims to study key factors of low carbon development strategy for sustainable transport. The Bangkok Mass Rapid Transit System (MRT) located in Bangkok was the study area. Data collection was using semi-structured in-depth interview protocol with thirty respondents consisting of six groups i.e. governmental agencies, the MRT operators, consulting companies, international organizations, non-profit organizations, and experts. The research findings highlighted the major factors and supplemental elements composing of institution and technical capacity, institutional framework, policy setting and process, and plan of implementation that would support more effective strategic process for low carbon development strategy (LCDS) for sustainable transport. The study would highly recommend on readiness of institution and technical capacities, stakeholder mapping, high-level decision- makers participation, and a clear direction of the governmental policies that are strongly needed in achieving the sustainable transport.

Epidemiology and outcome analysis of hand burns: A 5-year retrospective review of 378 cases in a burn center in Eastern China.

PubMed

Wang, Kang-an; Sun, Yu; Wu, Guo-sheng; Wang, Yi-ru; Xia, Zhao-fan

2015-11-01

Hands are frequent sites of burn but few related studies were reported in China. The aim of this study was to examine the impacts of gender, age, seasons, place, etiology, total body surface area (TBSA), depth, infection and comorbidities on prognosis following injury in a cohort of hand burn inpatients. This is a retrospective study of total 378 inpatients admitted to the burn center of Changhai hospital from January 2009 to December 2013. The present research showed the male inpatients were predominant and most of the inpatients aged from 20 to 49. Flame (37.04%) and electricity (25.40%) were the major causes of hand burns. Hand burns happened more commonly in work place (60.85%). The study preliminarily pointed out that male, flame and depth were the most significant factors impacting surgery. The main factors relevant to amputation were identified including the electrical burns and other etiology of burns. In addition, depth of hand burns was proved to have a higher impact on length of hospital stay (LOS) than other factors. The results of this study not only provide the necessary information of hand burns in Eastern China but also give the suggestions for the prevention of hand burns. Copyright © 2015 Elsevier Ltd and ISBI. All rights reserved.

The Impact of Neuroimmune Alterations in Autism Spectrum Disorder

PubMed Central

Gottfried, Carmem; Bambini-Junior, Victorio; Francis, Fiona; Riesgo, Rudimar; Savino, Wilson

2015-01-01

Autism spectrum disorder (ASD) involves a complex interplay of both genetic and environmental risk factors, with immune alterations and synaptic connection deficiency in early life. In the past decade, studies of ASD have substantially increased, in both humans and animal models. Immunological imbalance (including autoimmunity) has been proposed as a major etiological component in ASD, taking into account increased levels of pro-inflammatory cytokines observed in postmortem brain from patients, as well as autoantibody production. Also, epidemiological studies have established a correlation of ASD with family history of autoimmune diseases; associations with major histocompatibility complex haplotypes and abnormal levels of immunological markers in the blood. Moreover, the use of animal models to study ASD is providing increasing information on the relationship between the immune system and the pathophysiology of ASD. Herein, we will discuss the accumulating literature for ASD, giving special attention to the relevant aspects of factors that may be related to the neuroimmune interface in the development of ASD, including changes in neuroplasticity. PMID:26441683

Ergonomics and sustainability--challenges from global supply chains.

PubMed

Hasle, Peter; Jensen, Per Langaa

2012-01-01

The development of globalised supply chains is a major challenge for sustainability. For several years, there has been discussion within the profession whether and how ergonomics and human factors can play a role. Based on our research, we have identified five major challenges from global supply chains especially related to the social aspects of sustainability: (1) criteria for social sustainability, (2) the role of key performance indicators in the management of supply chains, (3) the constant changes in supply chains, (4) the challenge in establishing participation, and (5) the development of agency and regulatory mechanisms. There are obviously no clear and simple solutions to these challenges. One possible avenue for progress might lie in acquiring a greater understanding of the challenges from global supply chains and developing a strategy which combines social and long-term business sustainability. Starting from such a basis, the next step would be to find ways for the ergonomics and human factors community to create international collaboration which can impact specific global supply chains.

Water pollution in Pakistan and its impact on public health--a review.

PubMed

Azizullah, Azizullah; Khattak, Muhammad Nasir Khan; Richter, Peter; Häder, Donat-Peter

2011-02-01

Water pollution is one of the major threats to public health in Pakistan. Drinking water quality is poorly managed and monitored. Pakistan ranks at number 80 among 122 nations regarding drinking water quality. Drinking water sources, both surface and groundwater are contaminated with coliforms, toxic metals and pesticides throughout the country. Various drinking water quality parameters set by WHO are frequently violated. Human activities like improper disposal of municipal and industrial effluents and indiscriminate applications of agrochemicals in agriculture are the main factors contributing to the deterioration of water quality. Microbial and chemical pollutants are the main factors responsible exclusively or in combination for various public health problems. This review discusses a detailed layout of drinking water quality in Pakistan with special emphasis on major pollutants, sources of pollution and the consequent health problems. The data presented in this review are extracted from various studies published in national and international journals. Also reports released by the government and non-governmental organizations are included. Copyright © 2010 Elsevier Ltd. All rights reserved.

Impact of semaphorin expression on prognostic characteristics in breast cancer.

PubMed

Butti, Ramesh; Kumar, Totakura Vs; Nimma, Ramakrishna; Kundu, Gopal C

2018-01-01

Breast cancer is one of the major causes of cancer-related deaths among women worldwide. Aberrant regulation of various growth factors, cytokines, and other proteins and their receptors in cancer cells drives the activation of various oncogenic signaling pathways that lead to cancer progression. Semaphorins are a class of proteins which are differentially expressed in various types of cancer including breast cancer. Earlier, these proteins were known to have a major function in the nerve cell adhesion, migration, and development of the central nervous system. However, their role in the regulation of several aspects of tumor progression has eventually emerged. There are over 30 genes encoding the semaphorins, which are divided into eight subclasses. It has been reported that some members of semaphorin classes are antiangiogenic and antimetastatic in nature, whereas others act as proangiogenic and prometastatic genes. Because of their differential expression and role in angiogenesis and metastasis, semaphorins emerged as one of the important prognostic factors for appraising breast cancer progression.

ABA signaling in stress-response and seed development.

PubMed

Nakashima, Kazuo; Yamaguchi-Shinozaki, Kazuko

2013-07-01

KEY MESSAGE : We review the recent progress on ABA signaling, especially ABA signaling for ABA-dependent gene expression, including the AREB/ABF regulon, SnRK2 protein kinase, 2C-type protein phosphatases and ABA receptors. Drought negatively impacts plant growth and the productivity of crops. Drought causes osmotic stress to organisms, and the osmotic stress causes dehydration in plant cells. Abscisic acid (ABA) is produced under osmotic stress conditions, and it plays an important role in the stress response and tolerance of plants. ABA regulates many genes under osmotic stress conditions. It also regulates gene expression during seed development and germination. The ABA-responsive element (ABRE) is the major cis-element for ABA-responsive gene expression. ABRE-binding protein (AREB)/ABRE-binding factor (ABF) transcription factors (TFs) regulate ABRE-dependent gene expression. Other TFs are also involved in ABA-responsive gene expression. SNF1-related protein kinases 2 are the key regulators of ABA signaling including the AREB/ABF regulon. Recently, ABA receptors and group A 2C-type protein phosphatases were shown to govern the ABA signaling pathway. Moreover, recent studies have suggested that there are interactions between the major ABA signaling pathway and other signaling factors in stress-response and seed development. The control of the expression of ABA signaling factors may improve tolerance to environmental stresses.

Brain MRI white matter hyperintensities and one-carbon cycle metabolism in non-geriatric outpatients with major depressive disorder (Part I).

PubMed

Iosifescu, Dan V; Papakostas, George I; Lyoo, In Kyoon; Lee, Ho Kyu; Renshaw, Perry F; Alpert, Jonathan E; Nierenberg, Andrew; Fava, Maurizio

2005-12-30

The objective of the present work was to study the interrelationship between white matter hyperintensities (WMHs), cardiovascular risk factors and elements of the one-carbon cycle including serum folate, vitamin B12, and homocysteine levels in a relatively young sample of outpatients with major depressive disorder (MDD), and to compare the severity of white matter hyperintensities in MDD patients and healthy volunteers. Fifty MDD outpatients (34% women, age 40.6+/-10.3 years), free of psychotropic medications for at least 2 weeks before enrollment, underwent magnetic resonance imaging (MRI) scans of the brain to detect T2 WMHs and also had (1) serum folate, vitamin B12, homocysteine and cholesterol levels measured, and (2) cardiovascular risk factors assessed during the same study visit. Thirty-five healthy comparison subjects (40% women, age 39.2+/-9.8 years) also underwent brain MRI scans. Hypofolatemia, hypertension and age independently predicted a greater severity of total brain WMHs. Separately, the same factors also predicted a greater severity of subcortical WMHs. Hypofolatemic and hypertensive patients had more severe WMHs than normal controls. In light of the adverse impact of WMHs on a number of health-related outcomes later in life, hypofolatemia and hypertension may represent modifiable risk factors to prevent the occurrence of such adverse outcomes.

The journals of importance to UK clinicians: a questionnaire survey of surgeons

PubMed Central

Jones, Teresa H; Hanney, Steve; Buxton, Martin J

2006-01-01

Background Peer-reviewed journals are seen as a major vehicle in the transmission of research findings to clinicians. Perspectives on the importance of individual journals vary and the use of impact factors to assess research is criticised. Other surveys of clinicians suggest a few key journals within a specialty, and sub-specialties, are widely read. Journals with high impact factors are not always widely read or perceived as important. In order to determine whether UK surgeons consider peer-reviewed journals to be important information sources and which journals they read and consider important to inform their clinical practice, we conducted a postal questionnaire survey and then compared the findings with those from a survey of US surgeons. Methods A questionnaire survey sent to 2,660 UK surgeons asked which information sources they considered to be important and which peer-reviewed journals they read, and perceived as important, to inform their clinical practice. Comparisons were made with numbers of UK NHS-funded surgery publications, journal impact factors and other similar surveys. Results Peer-reviewed journals were considered to be the second most important information source for UK surgeons. A mode of four journals read was found with academics reading more than non-academics. Two journals, the BMJ and the Annals of the Royal College of Surgeons of England, are prominent across all sub-specialties and others within sub-specialties. The British Journal of Surgery plays a key role within three sub-specialties. UK journals are generally preferred and readership patterns are influenced by membership journals. Some of the journals viewed by surgeons as being most important, for example the Annals of the Royal College of Surgeons of England, do not have high impact factors. Conclusion Combining the findings from this study with comparable studies highlights the importance of national journals and of membership journals. Our study also illustrates the complexity of the link between the impact factors of journals and the importance of the journals to clinicians. This analysis potentially provides an additional basis on which to assess the role of different journals, and the published output from research. PMID:16762051

Internet and everyday life: the perceived implications of internet use on memory and ability to concentrate.

PubMed

Näsi, Matti; Koivusilta, Leena

2013-02-01

The growing role of Internet in all aspects of everyday life has led to speculations over the impacts beyond the traditional questions of access or sociability. This in mind, the main focus in this article was to examine how Finns, for majority of whom Internet use has become commonplace activity, perceive the impacts of Internet use since first adopting the technology. In this study, we examine how Internet user history and perceived computer skills, along with different sociodemographic factors, appear to reflect on the perceived impacts of Internet adoption in terms of memory and ability to concentrate. According to the results, almost one in five of the respondents reported changes concerning their memory or ability to concentrate, with skilled computer users and nonworkers, in particular, perceiving the change. Factors such as age-related differences and exposure to potential information overload at work were identified to explain the perceived change. Our data were collected in a survey-gathering information on the everyday life and well-being of Finns. The sample consisted of 2000 Finnish speakers aged 15 to 64 years. The response rate was 46 percent (N=908).

Chemical footprint method for improved communication of freshwater ecotoxicity impacts in the context of ecological limits.

PubMed

Bjørn, Anders; Diamond, Miriam; Birkved, Morten; Hauschild, Michael Zwicky

2014-11-18

The ecological footprint method has been successful in communicating environmental impacts of anthropogenic activities in the context of ecological limits. We introduce a chemical footprint method that expresses ecotoxicity impacts from anthropogenic chemical emissions as the dilution needed to avoid freshwater ecosystem damage. The indicator is based on USEtox characterization factors with a modified toxicity reference point. Chemical footprint results can be compared to the actual dilution capacity within the geographic vicinity receiving the emissions to estimate whether its ecological limit has been exceeded and hence whether emissions can be expected to be environmentally sustainable. The footprint method was illustrated using two case studies. The first was all inventoried emissions from European countries and selected metropolitan areas in 2004, which indicated that the dilution capacity was likely exceeded for most European countries and all landlocked metropolitan areas. The second case study indicated that peak application of pesticides alone was likely to exceed Denmark's freshwater dilution capacity in 1999-2011. The uncertainty assessment showed that better spatially differentiated fate factors would be useful and pointed out other major sources of uncertainty and some opportunities to reduce these.

Impact of anthropogenic and natural environmental changes on Echinococcus transmission in Ningxia Hui Autonomous Region, the People’s Republic of China

PubMed Central

2012-01-01

Echinococcus transmission is known to be affected by various environmental factors, which may be modified by human influence or natural events including global warming. Considerable population growth in the last fifty years in Ningxia Hui Autonomous Region (NHAR), the People’s Republic of China (PRC), has led to dramatic increases in deforestation and modified agricultural practices. In turn, this has resulted in many changes in the habitats for the definitive and intermediate hosts of both Echinococcus granulosus and E. multilocularis, which have increased the risks for transmission of both parasites, affecting echinococcosis prevalence and human disease. Ecological environmental changes due to anthropogenic activities and natural events drive Echinococcus transmission and NHAR provides a notable example illustrating how human activity can impact on a parasitic infection of major public health significance. It is very important to continually monitor these environmental (including climatic) factors that drive the distribution of Echinococcus spp. and their impact on transmission to humans because such information is necessary to formulate reliable future public health policy for echinococcosis control programs and to prevent disease spread. PMID:22827890

Risk factor modifications and depression incidence: a 4-year longitudinal Canadian cohort of the Montreal Catchment Area Study

PubMed Central

Meng, Xiangfei; Brunet, Alain; Turecki, Gustavo; Liu, Aihua; D'Arcy, Carl; Caron, Jean

2017-01-01

Objective Few studies have examined the effect of risk factor modifications on depression incidence. This study was to explore psychosocial risk factors for depression and quantify the effect of risk factor modifications on depression incidence in a large-scale, longitudinal population-based study. Methods Data were from the Montreal Longitudinal Catchment Area study (N=2433). Multivariate modified Poisson regression was used to estimate relative risk (RR). Population attributable fractions were also used to estimate the potential impact of risk factor modifications on depression incidence. Results The cumulative incidence rate of major depressive disorder at the 2-year follow-up was 4.8%, and 6.6% at the 4-year follow-up. Being a younger adult, female, widowed, separated or divorced, Caucasian, poor, occasional drinker, having a family history of mental health problems, having less education and living in areas with higher unemployment rates and higher proportions of visible minorities, more cultural community centres and community organisations, were consistently associated with the increased risk of incident major depressive disorder. Although only 5.1% of the disease incidence was potentially attributable to occasional drinking (vs abstainers) at the 2-year follow-up, the attribution of occasional drinking doubled at the 4-year follow-up. A 10% reduction in the prevalence of occasional drinking in this population could potentially prevent half of incident cases. Conclusions Modifiable risk factors, both individual and societal, could be the targets for public depression prevention programmes. These programmes should also be gender-specific, as different risk factors have been identified for men and women. Public health preventions at individual levels could focus on the better management of occasional drinking, as it explained around 5%~10% of incident major depressive disorders. Neighbourhood characteristics could also be the target for public prevention programmes. However, this could be very challenging. A cost-effectiveness analysis of a variety of prevention efforts is warranted. PMID:28601831

Fate of abstracts presented at a National Turkish Orthopedics and Traumatology Congress: publication rates and consistency of abstracts compared with their subsequent full-text publications.

PubMed

Yalçınkaya, Merter; Bagatur, Erdem

2013-01-01

The aim of this study was to evaluate the publication rates of full-text articles after presentation of abstracts at a Turkish National Orthopaedics and Traumatology Congress, determine the time lag from the congress date to publication of full-text articles and assess the consistency between abstracts and the subsequent publications. All abstracts from the scientific program of the 20th Turkish National Orthopaedics and Traumatology Congress (2007) were identified and computerized PubMed searches were conducted to determine whether an abstract had been followed by publication of a full-text article and key features were compared to evaluate their consistency. The time lag to publication and the impact factors of the journals where the articles were published were noted. Of the 770 abstracts (264 oral, 506 poster presentations), 227 (29.5%) were followed by a full-text and 116 (44%) of the 264 oral and 111 (22%) of the 506 poster presentations were published. The mean time to publication was 14.9±16.075 (range: 33 to 55) months. Thirty-three (14.5%) were published prior to the presentation at the congress. The likelihood of publication decreased after the third year (26 of 227, 11.5%). A total of 182 (80.2%) articles showed inconsistencies with the abstract; 74 (32.6%) minor, 14 (6.2%) major, and 94 (41.4%) minor and major inconsistencies. The mean impact factor of the journals was 1.152±0.858. The vast majority of abstracts presented at this congress were not followed by publication of a full-text article. Additionally, frequent inconsistencies between the final published article and the original abstract indicated the inadequacy of quality of reporting in abstracts.

Endoscope reprocessing methods: a prospective study on the impact of human factors and automation.

PubMed

Ofstead, Cori L; Wetzler, Harry P; Snyder, Alycea K; Horton, Rebecca A

2010-01-01

The main cause of endoscopy-associated infections is failure to adhere to reprocessing guidelines. More information about factors impacting compliance is needed to support the development of effective interventions. The purpose of this multisite, observational study was to evaluate reprocessing practices, employee perceptions, and occupational health issues. Data were collected utilizing interviews, surveys, and direct observation. Written reprocessing policies and procedures were in place at all five sites, and employees affirmed the importance of most recommended steps. Nevertheless, observers documented guideline adherence, with only 1.4% of endoscopes reprocessed using manual cleaning methods with automated high-level disinfection versus 75.4% of those reprocessed using an automated endoscope cleaner and reprocessor. The majority reported health problems (i.e., pain, decreased flexibility, numbness, or tingling). Physical discomfort was associated with time spent reprocessing (p = .041). Discomfort diminished after installation of automated endoscope cleaners and reprocessors (p = .001). Enhanced training and accountability, combined with increased automation, may ensure guideline adherence and patient safety while improving employee satisfaction and health.

Occurrence and countermeasures of urban power grid accident

NASA Astrophysics Data System (ADS)

Wei, Wang; Tao, Zhang

2018-03-01

With the advance of technology, the development of network communication and the extensive use of power grids, people can get to know power grid accidents around the world through the network timely. Power grid accidents occur frequently. Large-scale power system blackout and casualty accidents caused by electric shock are also fairly commonplace. All of those accidents have seriously endangered the property and personal safety of the country and people, and the development of society and economy is severely affected by power grid accidents. Through the researches on several typical cases of power grid accidents at home and abroad in recent years and taking these accident cases as the research object, this paper will analyze the three major factors that cause power grid accidents at present. At the same time, combining with various factors and impacts caused by power grid accidents, the paper will put forward corresponding solutions and suggestions to prevent the occurrence of the accident and lower the impact of the accident.

Older Women's Sexual Desire Problems: Biopsychosocial Factors Impacting Them and Barriers to Their Clinical Assessment

PubMed Central

Maciel, Michelle; Laganà, Luciana

2014-01-01

Sexual desire is a major component of sexuality at any age, and inhibited desire is one of the main sexual dysfunctions reported by older women. Nonetheless, in medical settings, for a variety of reasons discussed herein, its assessment—as well as the assessment of older women's sexual health in general—is typically avoided or conducted by asking a single sex question. In this paper, we have reviewed the literature (most of which is preliminary in nature) regarding the main psychosocial and health factors that could impact older women's sexual desire, as well as potential obstacles to the assessment and treatment of this geriatric sexual issue. It is certainly advisable that medical care providers who are uncomfortable discussing older women's sexual concerns be prepared to make appropriate referrals to clinicians who possess the proper training to accurately assess and treat sexual challenges (and female sexual interest problems in particular) in this neglected patient population. PMID:24995267

Older women's sexual desire problems: biopsychosocial factors impacting them and barriers to their clinical assessment.

PubMed

Maciel, Michelle; Laganà, Luciana

2014-01-01

Sexual desire is a major component of sexuality at any age, and inhibited desire is one of the main sexual dysfunctions reported by older women. Nonetheless, in medical settings, for a variety of reasons discussed herein, its assessment--as well as the assessment of older women's sexual health in general--is typically avoided or conducted by asking a single sex question. In this paper, we have reviewed the literature (most of which is preliminary in nature) regarding the main psychosocial and health factors that could impact older women's sexual desire, as well as potential obstacles to the assessment and treatment of this geriatric sexual issue. It is certainly advisable that medical care providers who are uncomfortable discussing older women's sexual concerns be prepared to make appropriate referrals to clinicians who possess the proper training to accurately assess and treat sexual challenges (and female sexual interest problems in particular) in this neglected patient population.

Optimizing the flow of care for prevention and treatment of deep vein thrombosis and pulmonary embolism.

PubMed

Ecklund, M M

1995-11-01

Critically ill patients have multiple risk factors for deep vein thrombosis and pulmonary embolism. The majority of patients with pulmonary embolism have a lower extremity deep vein thrombosis as a source of origin. Pulmonary embolism causes a high mortality rate in the hemodynamically compromised individual. Awareness of risk factors relative to the development of deep vein thrombosis and pulmonary embolism is important for the critical care nurse. Understanding the pathophysiology can help guide prophylaxis and treatment plans. The therapies, from invasive to mechanical, all carry risks and benefits, and are weighed for each patient. The advanced practice nurse, whether in the direct or indirect role, has an opportunity to impact the care of the high risk patient. Options range from teaching the nurse who is new to critical care, to teaching patients and families. Development of multidisciplinary protocols and clinical pathways are ways to impact the standard of care. Improved delivery of care methods can optimize the care rendered in an ever changing field of critical care.

From Interfaces to Bulk: Experimental-Computational Studies Across Time and Length Scales of Multi-Functional Ionic Polymers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Perahia, Dvora; Grest, Gary S.

Neutron experiments coupled with computational components have resulted in unprecedented understanding of the factors that impact the behavior of ionic structured polymers. Additionally, new computational tools to study macromolecules, were developed. In parallel, this DOE funding have enabled the education of the next generation of material researchers who are able to take the advantage neutron tools offer to the understanding and design of advanced materials. Our research has provided unprecedented insight into one of the major factors that limits the use of ionizable polymers, combining the macroscopic view obtained from the experimental techniques with molecular insight extracted from computational studiesmore » leading to transformative knowledge that will impact the design of nano-structured, materials. With the focus on model systems, of broad interest to the scientific community and to industry, the research addressed challenges that cut across a large number of polymers, independent of the specific chemical structure or the transported species.« less