In Search of Air Pollution

ERIC Educational Resources Information Center

Beckendorf, Kirk

2006-01-01

Air pollution is no longer just a local issue; it is a global problem. The atmosphere is a very dynamic system. Pollution not only changes in chemical composition after it is emitted, but also is transported on local and global air systems hundreds and even thousands of miles away. Some of the pollutants that are major health concerns are not even…

The globalization of epidemiology: introductory remarks.

PubMed

Pearce, Neil

2004-10-01

We are all living in the era of globalization, and like it or not, it is going to change the way we practice epidemiology, the kinds of questions we ask, and the methods we use to answer them. Increasingly, pubic health problems are being shifted from rich countries to poor countries and from rich to poor populations within Western countries. There is increasing interest and concern about the situation in non-Western populations on the part of Western epidemiologists, with regards to collaborative research, skills transfer, and 'volunteerism' to enable the 'benefits' of Western approaches to epidemiology to be shared by the non-Western world. However, most existing collaborations benefit Western epidemiologists rather than the countries in which the research is conducted. Even when research in non-Western populations is conducted as a genuine collaboration, it can too often 'export failure' from the West. On the other hand, non-Western epidemiologists are increasingly developing new and innovative approaches to health research that are more appropriate to the global public health issues they are addressing. These include recognition of the importance of context and the importance of diversity and local knowledge, and a problem-based approach to addressing the major public health problems using appropriate technology. These debates formed the background for a plenary session on 'International Epidemiology and International Health' at the recent International Epidemiological Association (IEA) meeting in Montreal, and the papers from this session are presented here. The development of a truly global epidemiology can not only better address the public health problems in non-Western populations, but can shed light on the current limitations of epidemiology in addressing the major public health problems in the West.

Processionary Moths and Associated Urtication Risk: Global Change-Driven Effects.

PubMed

Battisti, Andrea; Larsson, Stig; Roques, Alain

2017-01-31

Processionary moths carry urticating setae, which cause health problems in humans and other warm-blooded animals. The pine processionary moth Thaumetopoea pityocampa has responded to global change (climate warming and increased global trade) by extending its distribution range. The subfamily Thaumetopoeinae consists of approximately 100 species. An important question is whether other processionary moth species will similarly respond to these specific dimensions of global change and thus introduce health hazards into new areas. We describe, for the first time, how setae are distributed on different life stages (adult, larva) of major groups within the subfamily. Using the available data, we conclude that there is little evidence that processionary moths as a group will behave like T. pityocampa and expand their distributional range. The health problems caused by setae strongly relate to population density, which may, or may not, be connected to global change.

Commercial influence and global nongovernmental public action in health and pharmaceutical policies.

PubMed

Koivusalo, Meri; Mackintosh, Maureen

2011-01-01

Nongovernmental public action has been effective in influencing global agenda-setting in health and pharmaceutical policies, yet its record in influencing solutions to the problems identified has been notably more limited. While trade policies have been particularly resistant to change, more substantial changes are observable in global health policies and global health governance. However, some of the directions of change may not be conducive to the democratic accountability of global health governance, to the wise use of public resources, to health systems development, or to longer-term access to health care within developing countries. The authors argue that observed changes in global health policies can be understood as accommodating to corporate concerns and priorities. Furthermore, the changing global context and the commercialization of global public action itself pose sharp challenges to the exercise of influence by global nongovernmental public actors. Nongovernmental organizations not only face a major challenge in terms of the imbalance in power and resources between themselves and corporate interest groups when seeking to influence policymaking; they also face the problem of corporate influence on public action itself.

The Relationship of College Student Perceptions of Global Warming to Nine Demographic Variables.

ERIC Educational Resources Information Center

Groves, Fred H.; Pugh, Ava F.

Elementary and secondary students hold a variety of misunderstandings regarding environmental problems, some of which may arise from misunderstandings held by their teachers. This study used the Environmental Issues Questionnaire to examine understandings of the greenhouse effect held by elementary education majors and other college majors (N=330)…

The importance of economics in fire management analysis

Treesearch

Robert Mavsar; Armando González-Cabán; Verónica Farrera

2010-01-01

Wildfires are a societal problem that threatens many ecosystems, affects millions of people worldwide, and causes major ecosystem and economic impacts at local regional, national and global scales. In Europe, and especially in the Mediterranean countries (France, Greece, Italy, Portugal and Spain), wildfires continue to be a major environmental threat (Requardt et al....

Global Health Governance at a Crossroads.

PubMed

Ng, Nora Y; Ruger, Jennifer Prah

2011-06-21

This review takes stock of the global health governance (GHG) literature. We address the transition from international health governance (IHG) to global health governance, identify major actors, and explain some challenges and successes in GHG. We analyze the framing of health as national security, human security, human rights, and global public good, and the implications of these various frames. We also establish and examine from the literature GHG's major themes and issues, which include: 1) persistent GHG problems; 2) different approaches to tackling health challenges (vertical, horizontal, and diagonal); 3) health's multisectoral connections; 4) neoliberalism and the global economy; 5) the framing of health (e.g. as a security issue, as a foreign policy issue, as a human rights issue, and as a global public good); 6) global health inequalities; 7) local and country ownership and capacity; 8) international law in GHG; and 9) research gaps in GHG. We find that decades-old challenges in GHG persist and GHG needs a new way forward. A framework called shared health governance offers promise.

Global Health Governance at a Crossroads

PubMed Central

Ng, Nora Y.; Ruger, Jennifer Prah

2014-01-01

This review takes stock of the global health governance (GHG) literature. We address the transition from international health governance (IHG) to global health governance, identify major actors, and explain some challenges and successes in GHG. We analyze the framing of health as national security, human security, human rights, and global public good, and the implications of these various frames. We also establish and examine from the literature GHG’s major themes and issues, which include: 1) persistent GHG problems; 2) different approaches to tackling health challenges (vertical, horizontal, and diagonal); 3) health’s multisectoral connections; 4) neoliberalism and the global economy; 5) the framing of health (e.g. as a security issue, as a foreign policy issue, as a human rights issue, and as a global public good); 6) global health inequalities; 7) local and country ownership and capacity; 8) international law in GHG; and 9) research gaps in GHG. We find that decades-old challenges in GHG persist and GHG needs a new way forward. A framework called shared health governance offers promise. PMID:24729828

Substance abuse and rehabilitation: responding to the global burden of diseases attributable to substance abuse.

PubMed

Wu, Li-Tzy

2010-10-01

Alcohol, tobacco, and illegal drug use are pervasive throughout the world. Substance use problems are among the major contributors to the global disease burden, which includes disability and mortality. The benefits of treatment far outweigh the economic costs. Despite the availability of treatment services, however, the vast majority of people with substance use disorders do not seek or use treatment. Barriers to and unmet need for evidence-based treatment are widespread even in the United States. Women, adolescents, and young adults are especially vulnerable to adverse effects from substance abuse, but they face additional barriers to getting evidence-based treatment or other social/medical services. Substance use behaviors and the diseases attributable to substance use problems are preventable and modifiable. Yet the ever-changing patterns of substance use and associated problems require combined research and policy-making efforts from all parts of the world to establish a viable knowledge base to inform for prevention, risk-reduction intervention, effective use of evidence-based treatment, and rehabilitation for long-term recovery. The new international, open-access, peer-reviewed Substance Abuse and Rehabilitation (SAR) journal strives to provide an effective platform for sharing ideas for solutions and disseminating research findings globally. Substance use behaviors and problems have no boundaries. The journal welcomes papers from all regions of the world that address any aspect of substance use, abuse/dependence, intervention, treatment, and policy. The "open-access" journal makes cutting edge knowledge freely available to practitioners and researchers worldwide, and this is particularly important for addressing the global disease burden attributable to substance abuse.

Towards Reducing the Burden of Global Environmental Related Health Problems in the 21st Century

ERIC Educational Resources Information Center

Olanipekun, Johnson Adetunji; Babatunde, Joseph Ojo

2016-01-01

Environmental health issues are major risk factors in the global burden of disease. This paper therefore focuses on the most important link between health and environment. It discusses the most important environmental threats to health in the 21st Century especially in the low and middle income countries. It reviews the burden of disease from…

Interdisciplinary Explorations: Promoting Critical Thinking via Problem-Based Learning in an Advanced Biochemistry Class

ERIC Educational Resources Information Center

Cowden, Chapel D.; Santiago, Manuel F.

2016-01-01

Interdisciplinary approaches to research in the sciences have become increasingly important in solving a wide range of pressing problems at both global and local levels. It is imperative then that science majors in higher education understand the need for exploring information from a wide array of disciplines. With this in mind, interdisciplinary…

The United States and World Development: Agenda 1980.

ERIC Educational Resources Information Center

Sewell, John W.; And Others

This publication examines global problems facing the United States and offers a specific short-term program of action to deal with some of the problems. There are three major parts. Part I describes political and economic developments in both rich and poor countries and comments on the recent record of the United States in its relationships with…

Sugary beverages represent a threat to global health.

PubMed

Popkin, Barry M

2012-12-01

Sugary beverages represent a major global threat to the health of all populations. The shifts in distribution, marketing, and sales have made them the plague of the globe in terms of obesity, diabetes, and a host of other chronic health problems. The fructose-laden beverages have unique properties that lead to lack of dietary compensation and direct adverse effects on our health. Global efforts to limit marketing and sales are necessary to protect the health of the planet. Copyright © 2012 Elsevier Ltd. All rights reserved.

Space and Missile Defense Acquisitions: Periodic Assessment Needed to Correct Parts Quality Problems in Major Programs

DTIC Science & Technology

2011-06-01

understanding of the global water cycle and the accuracy of precipitation forecasts. GPM is composed of a core spacecraft carrying two main instruments: a dual...developed by NASA and the Space Agency of Argentina (Comisión Nacional de Actividades Espaciales) to investigate the links between the global water ... cycle , ocean circulation, and the climate. It will measure global sea surface salinity. The Aquarius science goals are to observe and model the

Global cancer research initiative

PubMed Central

Love, Richard R

2010-01-01

Cancer is an increasing problem for low- and middle-income countries undergoing an epidemiologic transition from dominantly acute communicable disease to more frequent chronic disease with increased public health successes in the former domain. Progress against cancer in high-income countries has been modest and has come at enormous expense. There are several well-conceived global policy and planning initiatives which, with adequate political will, can favorably impact the growing global cancer challenges. Most financial resources for cancer, however, are spent on diagnosis and management of patients with disease in circumstances where specific knowledge about effective approaches is significantly limited, and the majority of interventions, other than surgery, are not cost-effective in resource-limited countries by global standards. In summary, how to intervene effectively on a global scale for the majority of citizens who develop cancer is poorly defined. In contrast to technology-transfer approaches, markedly increased clinical research activities are more likely to benefit cancer sufferers. In these contexts, a global cancer research initiative is proposed, and mechanisms for realizing such an effort are suggested. PMID:21188101

Towards a global alcohol policy: alcohol, public health and the role of WHO.

PubMed Central

Jernigan, D. H.; Monteiro, M.; Room, R.; Saxena, S.

2000-01-01

In 1983 the World Health Assembly declared alcohol-related problems to be among the world's major health concerns. Since then, alcohol consumption has risen in developing countries, where it takes a heavy toll. Alcohol-related problems are at epidemic levels in the successor states of the Soviet Union and are responsible for 3.5% of disability-adjusted life years (DALYs) lost globally. Substantial evidence exists of the relationship between the levels and patterns of alcohol consumption on the one hand and the incidence of alcohol-related problems on the other. Over the past 20 years, research has demonstrated the effectiveness of public policies involving, for example, taxation and restrictions on alcohol availability, in reducing alcohol-related problems. In the wake of rapid economic globalization, many of these policies at national and subnational levels have been eroded, often with the support of international financial and development organizations. Development agencies and international trade agreements have treated alcohol as a normal commodity, overlooking the adverse consequences of its consumption on productivity and health. WHO is in a strong position to take the lead in developing a global alcohol policy aimed at reducing alcohol-related problems, providing scientific and statistical support, capacity-building, disseminating effective strategies and collaborating with other international organizations. Such leadership can play a significant part in diminishing the health and social problems associated with alcohol use. PMID:10885168

Environment.

ERIC Educational Resources Information Center

White, Gilbert F.

1980-01-01

Presented are perspectives on the emergence of environmental problems. Six major trends in scientific thinking are identified including: holistic approaches to examining environments, life support systems, resource management, risk assessment, streamlined methods for monitoring environmental change, and emphasis on the global framework. (Author/SA)

A Decision Model for Supporting Task Allocation Processes in Global Software Development

NASA Astrophysics Data System (ADS)

Lamersdorf, Ansgar; Münch, Jürgen; Rombach, Dieter

Today, software-intensive systems are increasingly being developed in a globally distributed way. However, besides its benefit, global development also bears a set of risks and problems. One critical factor for successful project management of distributed software development is the allocation of tasks to sites, as this is assumed to have a major influence on the benefits and risks. We introduce a model that aims at improving management processes in globally distributed projects by giving decision support for task allocation that systematically regards multiple criteria. The criteria and causal relationships were identified in a literature study and refined in a qualitative interview study. The model uses existing approaches from distributed systems and statistical modeling. The article gives an overview of the problem and related work, introduces the empirical and theoretical foundations of the model, and shows the use of the model in an example scenario.

Energy and the Confused Student IV: A Global Approach to Energy

ERIC Educational Resources Information Center

Jewett, John W., Jr.

2008-01-01

Energy is a critical concept in physics problem-solving, but is often a major source of confusion for students if the presentation is not carefully crafted by the instructor or the textbook. In the first three articles in this series we discussed several issues related to the teaching of energy concepts. We have saved a major single issue for this…

Is vitamin D deficiency a major global public health problem?

PubMed

Palacios, Cristina; Gonzalez, Lilliana

2014-10-01

Vitamin D deficiency is a major public health problem worldwide in all age groups, even in those residing in countries with low latitude, where it was generally assumed that UV radiation was adequate enough to prevent this deficiency, and in industrialized countries, where vitamin D fortification has been implemented now for years. However, most countries are still lacking data, particularly population representative data, with very limited information in infants, children, adolescents and pregnant women. Since the number of recent publications is escalating, with a broadening of the geographic diversity, the objective of the present report was to conduct a more recent systematic review of global vitamin D status, with particular emphasis in at risk groups. A systematic review was conducted in PubMed/Medline in April-June 2013 to identify articles on vitamin D status worldwide published in the last 10 years in apparently healthy individuals. Only studies with vitamin D status prevalence were included. If available, the first source selected was population-based or representative samples studies. Clinical trials, case-control studies, case reports or series, reviews, validation studies, letters, editorials, or qualitative studies were excluded. A total of 103 articles were eligible and included in the present report. Maps were created for each age group, providing an updated overview of global vitamin D status. In areas with available data, the prevalence of low vitamin D status is a global problem in all age groups, in particular in girls and women from the Middle East. These maps also evidenced the regions with missing data for each specific population groups. There is striking lack of data in infants, children and adolescents worldwide, and in most countries of South America and Africa. In conclusion, vitamin D deficiency is a global public health problem in all age groups, particularly in those from the Middle East. This article is part of a Special Issue entitled '16th Vitamin D Workshop'. Copyright © 2013 Elsevier Ltd. All rights reserved.

Road-traffic injuries: confronting disparities to address a global-health problem.

PubMed

Ameratunga, Shanthi; Hijar, Martha; Norton, Robyn

2006-05-06

Evidence suggests that the present and projected global burden of road-traffic injuries is disproportionately borne by countries that can least afford to meet the health service, economic, and societal challenges posed. Although the evidence base on which these estimates are made remains somewhat precarious in view of the limited data systems in most low-income and middle-income countries (as per the classification on the World Bank website), these projections highlight the essential need to address road-traffic injuries as a public-health priority. Most well-evaluated effective interventions do not directly focus on efforts to protect vulnerable road users, such as motorcyclists and pedestrians. Yet, these groups comprise the majority of road-traffic victims in low-income and middle-income countries, and consequently, the majority of the road-traffic victims globally. Appropriately responding to these disparities in available evidence and prevention efforts is necessary if we are to comprehensively address this global-health dilemma.

Remote Sensing and Problems of the Hydrosphere

NASA Technical Reports Server (NTRS)

Goldberg, E. D. (Editor)

1979-01-01

A discussion of freshwater and marine systems is presented including areas of the classification of lakes, identification and quantification of major functional groups of phytoplankton, sources and sinks of biochemical factors, and temporal and regional variability of surface features. Atmospheric processes linked to hydrospheric process through the transfer of matter via aerosols and gases are discussed. Particle fluxes to the aquatic environment and global geochemical problems are examined.

Fascioliasis: An Ongoing Zoonotic Trematode Infection

PubMed Central

Nyindo, Mramba; Lukambagire, Abdul-Hamid

2015-01-01

Zoonotic trematode infections are an area of the neglected tropical diseases that have become of major interest to global and public health due to their associated morbidity. Human fascioliasis is a trematode zoonosis of interest in public health. It affects approximately 50 million people worldwide and over 180 million are at risk of infection in both developed and underdeveloped countries. The one health paradigm is an area that seeks to address the problem of zoonotic infections through a comprehensive and sustainable approach. This review attempts to address the major challenges in managing human and animal fascioliasis with valuable insights gained from the one health paradigm to global health and multidisciplinary integration. PMID:26417603

Fascioliasis: An Ongoing Zoonotic Trematode Infection.

PubMed

Nyindo, Mramba; Lukambagire, Abdul-Hamid

2015-01-01

Zoonotic trematode infections are an area of the neglected tropical diseases that have become of major interest to global and public health due to their associated morbidity. Human fascioliasis is a trematode zoonosis of interest in public health. It affects approximately 50 million people worldwide and over 180 million are at risk of infection in both developed and underdeveloped countries. The one health paradigm is an area that seeks to address the problem of zoonotic infections through a comprehensive and sustainable approach. This review attempts to address the major challenges in managing human and animal fascioliasis with valuable insights gained from the one health paradigm to global health and multidisciplinary integration.

Malnutrition, a Global Problem

USDA-ARS?s Scientific Manuscript database

Malnutrition is a general term for medical conditions caused by an inadequate diet and poor nutrition. Hunger and malnutrition are among the major difficulties confronting many countries around the world. Malnutrition can be caused by several factors, such as the sharp increase in population (curren...

Silencing women’s sexuality: global AIDS policies and the case of the female condom

PubMed Central

Peters, Anny JTP; van Driel, Francien TM; Jansen, Willy HM

2013-01-01

Introduction The female condom is the only evidence-based AIDS prevention technology that has been designed for the female body; yet, most women do not have access to it. This is remarkable since women constitute the majority of all HIV-positive people living in sub-Saharan Africa, and gender inequality is seen as a driving force of the AIDS epidemic. In this study, we analyze how major actors in the AIDS prevention field frame the AIDS problem, in particular the female condom in comparison to other prevention technologies, in their discourse and policy formulations. Our aim is to gain insight into the discursive power mechanisms that underlie the thinking about AIDS prevention and women’s sexual agency. Methods We analyze the AIDS policies of 16 agencies that constitute the most influential actors in the global response to AIDS. Our study unravels the discursive power of these global AIDS policy actors, when promoting and making choices between AIDS prevention technologies. We conducted both a quantitative and qualitative analysis of how the global AIDS epidemic is being addressed by them, in framing the AIDS problem, labelling of different categories of people for targeting AIDS prevention programmes and in gender marking of AIDS prevention technologies. Results We found that global AIDS policy actors frame the AIDS problem predominantly in the context of gender and reproductive health, rather than that of sexuality and sexual rights. Men’s sexual agency is treated differently from women’s sexual agency. An example of such differentiation and of gender marking is shown by contrasting the framing and labelling of male circumcision as an intervention aimed at the prevention of HIV with that of the female condom. Conclusions The gender-stereotyped global AIDS policy discourse negates women’s agency in sexuality and their sexual rights. This could be an important factor in limiting the scale-up of female condom programmes and hampering universal access to female condoms. PMID:23838151

A global, multi-disciplinary, multi-sectorial initiative to combat leptospirosis: Global Leptospirosis Environmental Action Network (GLEAN).

PubMed

Durski, Kara N; Jancloes, Michel; Chowdhary, Tej; Bertherat, Eric

2014-06-05

Leptospirosis has emerged as a major public health problem in both animals and humans. The true burden of this epidemic and endemic disease is likely to be grossly under-estimated due to the non-specific clinical presentations of the disease and the difficulty of laboratory confirmation. The complexity that surrounds the transmission dynamics, particularly in epidemic situations, requires a coordinated, multi-disciplinary effort. Therefore, the Global Leptospirosis Environmental Action Network (GLEAN) was developed to improve global and local strategies of how to predict, prevent, detect, and intervene in leptospirosis outbreaks in order to prevent and control leptospirosis in high-risk populations.

A Global, Multi-Disciplinary, Multi-Sectorial Initiative to Combat Leptospirosis: Global Leptospirosis Environmental Action Network (GLEAN)

PubMed Central

Durski, Kara N.; Jancloes, Michel; Chowdhary, Tej; Bertherat, Eric

2014-01-01

Leptospirosis has emerged as a major public health problem in both animals and humans. The true burden of this epidemic and endemic disease is likely to be grossly under-estimated due to the non-specific clinical presentations of the disease and the difficulty of laboratory confirmation. The complexity that surrounds the transmission dynamics, particularly in epidemic situations, requires a coordinated, multi-disciplinary effort. Therefore, the Global Leptospirosis Environmental Action Network (GLEAN) was developed to improve global and local strategies of how to predict, prevent, detect, and intervene in leptospirosis outbreaks in order to prevent and control leptospirosis in high-risk populations. PMID:24905245

Air pollution, greenhouse gases and climate change : global and regional perspectives

DOT National Transportation Integrated Search

2009-01-01

Greenhouse gases (GHGs) warm the surface and the atmosphere with significant implications for rainfall, retreat of glaciers and sea ice, sea level, among other factors. What is less recognized than problems with GHGs, however, is a comparably major g...

Tackling the threat of antimicrobial resistance: from policy to sustainable action

PubMed Central

Shallcross, Laura J.; Howard, Simon J.; Fowler, Tom; Davies, Sally C.

2015-01-01

Antibiotics underpin all of modern medicine, from routine major surgery through to caesarean sections and modern cancer therapies. These drugs have revolutionized how we practice medicine, but we are in a constant evolutionary battle to evade microbial resistance and this has become a major global public health problem. We have overused and misused these essential medicines both in the human and animal health sectors and this threatens the effectiveness of antimicrobials for future generations. We can only address the threat of antimicrobial resistance (AMR) through international collaboration across human and animal health sectors integrating social, economic and behavioural factors. Our global organizations are rising to the challenge with the recent World Health Assembly resolution on AMR and development of the Global Action plan but we must act now to avoid a return to a pre-antibiotic era. PMID:25918440

Neoliberalism, "globalization," unemployment, inequalities, and the welfare state.

PubMed

Navarro, V

1998-01-01

This analysis of "neoliberalism" and its economic and social consequences is presented in six sections. Section I begins by describing the impact of neoliberal public policies on economic growth and inflation, on business profits and business investments, on productivity, on business credit, on unemployment and social inequalities, on social expenditures, and on poverty and family debt. The author shows that, except in the area of business profits and control of inflation, neoliberal policies have not proved superior to those they replaced. Section II deals with unemployment and social polarization in the developed capitalist countries. The author criticizes some of the theories put forward to explain these social problems, such as the introduction of new technologies and globalization of the economy, and suggests that a primary reason for these problems is the implementation of neoliberal policies. Section III challenges the widely held neoliberal perception that the U.S. economy is highly efficient and the E.U. economies are "sclerotic" due to their "excessive" welfare states and "rigid" labor markets. The author shows that the U.S. economy is not so dynamic, nor the E.U. economies so sclerotic. Some developed countries with greater social protection and more regulated labor markets are shown to be more successful than the United States in producing jobs and lowering unemployment. The reasons for the growing polarization in developed capitalist countries, rooted in political rather than economic causes, are discussed in section IV--especially the enormous power of the financial markets and their influence on international agencies and national governments, and the weakness of the labor movements, both nationally and internationally. Section V questions the major theses of globalization. The author shows that rather than globalization of commerce and investments, we are witnessing a regionalization of economic relations stimulated by political considerations. He also analyzes the globalization of capital finance, criticizing the thesis that capital markets are determining public policies. The economic determinism that underlies the globalization position is questioned, uncovering the importance of political explanations for understanding major social problems such as unemployment. Finally, section VI shows that neoliberal public policies on the deregulation of labor markets are creating enormous instability in the labor force, worsening the living conditions of the majority of the populations.

Interferon Gamma Assay for the Diagnosis of Bovine Tuberculosis

USDA-ARS?s Scientific Manuscript database

Contact Irene Schiller Prionics AG Wagistrasse 27A CH-8952 Schlieren Switzerland irene.schiller@prionics.com Introduction Bovine tuberculosis (bTB), a zoonotic disease with a major economic impact, continues to be a significant problem with a global perspective and increasing prevalence in vario...

Exploring changes in river nitrogen export to the world's oceans

NASA Astrophysics Data System (ADS)

Bouwman, A. F.; van Drecht, G.; Knoop, J. M.; Beusen, A. H. W.; Meinardi, C. R.

2005-03-01

Anthropogenic disturbance of river nutrient loads and export to coastal marine systems is a major global problem affecting water quality and biodiversity. Nitrogen is the major nutrient in rivers. On the basis of projections for food production and wastewater effluents, the global river N flux to coastal marine systems is shown to increase by 13% in the coming 3 decades. While the river N flux will grow by about 10% in North America and Oceania and will decrease in Europe, a 27% increase is projected for developing countries, which is a continuation of the trend observed in the past decades. This is a consequence of increasing nitrogen inputs to surface water associated with urbanization, sanitation, development of sewerage systems, and lagging wastewater treatment, as well as increasing food production and associated inputs of N fertilizer, animal manure, atmospheric N deposition, and biological N fixation in agricultural systems. Growing river N loads will lead to increased incidence of problems associated with eutrophication in coastal seas.

Practical global oceanic state estimation

NASA Astrophysics Data System (ADS)

Wunsch, Carl; Heimbach, Patrick

2007-06-01

The problem of oceanographic state estimation, by means of an ocean general circulation model (GCM) and a multitude of observations, is described and contrasted with the meteorological process of data assimilation. In practice, all such methods reduce, on the computer, to forms of least-squares. The global oceanographic problem is at the present time focussed primarily on smoothing, rather than forecasting, and the data types are unlike meteorological ones. As formulated in the consortium Estimating the Circulation and Climate of the Ocean (ECCO), an automatic differentiation tool is used to calculate the so-called adjoint code of the GCM, and the method of Lagrange multipliers used to render the problem one of unconstrained least-squares minimization. Major problems today lie less with the numerical algorithms (least-squares problems can be solved by many means) than with the issues of data and model error. Results of ongoing calculations covering the period of the World Ocean Circulation Experiment, and including among other data, satellite altimetry from TOPEX/POSEIDON, Jason-1, ERS- 1/2, ENVISAT, and GFO, a global array of profiling floats from the Argo program, and satellite gravity data from the GRACE mission, suggest that the solutions are now useful for scientific purposes. Both methodology and applications are developing in a number of different directions.

Global Instability on Laminar Separation Bubbles-Revisited

NASA Technical Reports Server (NTRS)

Theofilis, Vassilis; Rodriquez, Daniel; Smith, Douglas

2010-01-01

In the last 3 years, global linear instability of LSB has been revisited, using state-of-the-art hardware and algorithms. Eigenspectra of LSB flows have been understood and classified in branches of known and newly-discovered eigenmodes. Major achievements: World-largest numerical solutions of global eigenvalue problems are routinely performed. Key aerodynamic phenomena have been explained via critical point theory, applied to our global mode results. Theoretical foundation for control of LSB flows has been laid. Global mode of LSB at the origin of observable phenomena. U-separation on semi-infinite plate. Stall cells on (stalled) airfoil. Receptivity/Sensitivity/AFC feasible (practical?) via: Adjoint EVP solution. Direct/adjoint coupling (the Crete connection). Minor effect of compressibility on global instability in the subsonic compressible regime. Global instability analysis of LSB in realistic supersonic flows apparently quite some way down the horizon.

A global response to a global problem: the epidemic of overnutrition.

PubMed Central

Chopra, Mickey; Galbraith, Sarah; Darnton-Hill, Ian

2002-01-01

It is estimated that by 2020 two-thirds of the global burden of disease will be attributable to chronic noncommunicable diseases, most of them strongly associated with diet. The nutrition transition towards refined foods, foods of animal origin, and increased fats plays a major role in the current global epidemics of obesity, diabetes and cardiovascular diseases, among other noncommunicable conditions. Sedentary lifestyles and the use of tobacco are also significant risk factors. The epidemics cannot be ended simply by encouraging people to reduce their risk factors and adopt healthier lifestyles, although such encouragement is undoubtedly beneficial if the targeted people can respond. Unfortunately, increasingly obesogenic environments, reinforced by many of the cultural changes associated with globalization, make even the adoption of healthy lifestyles, especially by children and adolescents, more and more difficult. The present paper examines some possible mechanisms for, and WHO's role in, the development of a coordinated global strategy on diet, physical activity and health. The situation presents many countries with unmanageable costs. At the same time there are often continuing problems of undernutrition. A concerted multisectoral approach, involving the use of policy, education and trade mechanisms, is necessary to address these matters. PMID:12571723

Recent developments in the theory of protein folding: searching for the global energy minimum.

PubMed

Scheraga, H A

1996-04-16

Statistical mechanical theories and computer simulation are being used to gain an understanding of the fundamental features of protein folding. A major obstacle in the computation of protein structures is the multiple-minima problem arising from the existence of many local minima in the multidimensional energy landscape of the protein. This problem has been surmounted for small open-chain and cyclic peptides, and for regular-repeating sequences of models of fibrous proteins. Progress is being made in resolving this problem for globular proteins.

Cuckoo Search with Lévy Flights for Weighted Bayesian Energy Functional Optimization in Global-Support Curve Data Fitting

PubMed Central

Gálvez, Akemi; Iglesias, Andrés; Cabellos, Luis

2014-01-01

The problem of data fitting is very important in many theoretical and applied fields. In this paper, we consider the problem of optimizing a weighted Bayesian energy functional for data fitting by using global-support approximating curves. By global-support curves we mean curves expressed as a linear combination of basis functions whose support is the whole domain of the problem, as opposed to other common approaches in CAD/CAM and computer graphics driven by piecewise functions (such as B-splines and NURBS) that provide local control of the shape of the curve. Our method applies a powerful nature-inspired metaheuristic algorithm called cuckoo search, introduced recently to solve optimization problems. A major advantage of this method is its simplicity: cuckoo search requires only two parameters, many fewer than other metaheuristic approaches, so the parameter tuning becomes a very simple task. The paper shows that this new approach can be successfully used to solve our optimization problem. To check the performance of our approach, it has been applied to five illustrative examples of different types, including open and closed 2D and 3D curves that exhibit challenging features, such as cusps and self-intersections. Our results show that the method performs pretty well, being able to solve our minimization problem in an astonishingly straightforward way. PMID:24977175

Cuckoo search with Lévy flights for weighted Bayesian energy functional optimization in global-support curve data fitting.

PubMed

Gálvez, Akemi; Iglesias, Andrés; Cabellos, Luis

2014-01-01

The problem of data fitting is very important in many theoretical and applied fields. In this paper, we consider the problem of optimizing a weighted Bayesian energy functional for data fitting by using global-support approximating curves. By global-support curves we mean curves expressed as a linear combination of basis functions whose support is the whole domain of the problem, as opposed to other common approaches in CAD/CAM and computer graphics driven by piecewise functions (such as B-splines and NURBS) that provide local control of the shape of the curve. Our method applies a powerful nature-inspired metaheuristic algorithm called cuckoo search, introduced recently to solve optimization problems. A major advantage of this method is its simplicity: cuckoo search requires only two parameters, many fewer than other metaheuristic approaches, so the parameter tuning becomes a very simple task. The paper shows that this new approach can be successfully used to solve our optimization problem. To check the performance of our approach, it has been applied to five illustrative examples of different types, including open and closed 2D and 3D curves that exhibit challenging features, such as cusps and self-intersections. Our results show that the method performs pretty well, being able to solve our minimization problem in an astonishingly straightforward way.

Why a Global International Waters Assessment (GIWA)?

PubMed

Hempel, Gotthilf; Daler, Dag

2004-02-01

Why GIWA? Six years ago several people had their doubts as to whether a Global International Waters Assessment would be worth the money and effort. Nowadays, it is no longer necessary to justify the creation of GIWA. On the contrary, we will show how important it was that the Global Environmental Facility (GEF) and UNEP, constituted GIWA. Countless water-related assessments focus on specific regions and/or specific issues. But GIWA is unique in its global and holistic policy-oriented approach applying a common methodology to address the major problems in all parts of the global hydrosphere. One major achievement of GIWA will be the GIWA publications which provide advice to GEF and other decision-making organizations. Further assets include the network of regional focal points and teams. GIWA encompasses marine, surface freshwater, and groundwater systems, following the flow of water from the sources in the mountains through the rivers and estuaries into the coastal waters and the shelf seas. GIWA studies the physical, chemical and biological properties of those waterbodies and living resources in relation to the human activities, combining ecological and socioeconomic considerations.

[Globalization, inequity and Chagas disease].

PubMed

Dias, João Carlos Pinto

2007-01-01

Chagas disease (American trypanosomiasis) bears a close relationship to multiple social and political aspects involving issues of globalization and inequity. Such relations concern the process of disease production and control in parallel with medical management. Despite the poverty in Latin America and various problems related to inequities and globalization, Chagas disease has been controlled in several areas, a fact that reinforces the countries' self-reliance. Several problems and challenges related to the disease can be expected in the future, mainly concerning medical care for already infected individuals and the sustainability of effective epidemiological surveillance. Both points depend heavily on improved performance by the national health systems, principally in terms of their efficiency and their capacity to overcome inequity. A particularly important role has been attributed to the Latin American scientific and academic community in the implementation and sustainability of efficient control policies. Control activities have now evolved towards internationally shared initiatives, a major new stride forward in the region's political context.

Can Better Accounting and Finance Methods Chart a Path toward a More Sustainable World System?

EPA Science Inventory

The Problem:Concerns about urbanization, climate change and the recognition that global fossil fuel resources are finite, provide important motivations for major environmental, economic and societal adjustments in the 21st century to achieve a more sustainable world. The develope...

Global burden of COPD.

PubMed

López-Campos, José Luis; Tan, Wan; Soriano, Joan B

2016-01-01

It is estimated that the world population will reach a record 7.3 billion in 2015, and the high burden of chronic conditions associated with ageing and smoking will increase further. Respiratory diseases in general receive little attention and funding in comparison with other major causes of global morbidity and mortality. In particular, chronic obstructive pulmonary disease (COPD) has been a major public health problem and will remain a challenge for clinicians within the 21st century. Worldwide, COPD is in the spotlight, since its high prevalence, morbidity and mortality create formidable challenges for health-care systems. This review emphasizes the magnitude of the COPD problem from a clinician's standpoint by drawing extensively from the new findings of the Global Burden of Disease study. Updated, distilled information on the population distribution of COPD is useful for the clinician to help provide an appreciation of the relative impact of COPD in daily practice compared with other chronic conditions, and to allocate minimum resources in anticipation of future needs in care. Despite recent trends in reduction of COPD standardized mortality rates and some recent successes in anti-smoking efforts in a number of Western countries, the overarching demographic impact of ageing in an ever-expanding world population, joined with other factors such as high rates of smoking and air pollution in Asia, will ensure that COPD will continue to pose an ever-increasing problem well into the 21st century. © 2015 Asian Pacific Society of Respirology.

Improvement of training set structure in fusion data cleaning using Time-Domain Global Similarity method

NASA Astrophysics Data System (ADS)

Liu, J.; Lan, T.; Qin, H.

2017-10-01

Traditional data cleaning identifies dirty data by classifying original data sequences, which is a class-imbalanced problem since the proportion of incorrect data is much less than the proportion of correct ones for most diagnostic systems in Magnetic Confinement Fusion (MCF) devices. When using machine learning algorithms to classify diagnostic data based on class-imbalanced training set, most classifiers are biased towards the major class and show very poor classification rates on the minor class. By transforming the direct classification problem about original data sequences into a classification problem about the physical similarity between data sequences, the class-balanced effect of Time-Domain Global Similarity (TDGS) method on training set structure is investigated in this paper. Meanwhile, the impact of improved training set structure on data cleaning performance of TDGS method is demonstrated with an application example in EAST POlarimetry-INTerferometry (POINT) system.

Vision for a Global Registry of Anticipated Public Health Studies

PubMed Central

Choi, Bernard C.K.; Frank, John; Mindell, Jennifer S.; Orlova, Anna; Lin, Vivian; Vaillancourt, Alain D.M.G.; Puska, Pekka; Pang, Tikki; Skinner, Harvey A.; Marsh, Marsha; Mokdad, Ali H.; Yu, Shun-Zhang; Lindner, M. Cristina; Sherman, Gregory; Barreto, Sandhi M.; Green, Lawrence W.; Svenson, Lawrence W.; Sainsbury, Peter; Yan, Yongping; Zhang, Zuo-Feng; Zevallos, Juan C.; Ho, Suzanne C.; de Salazar, Ligia M.

2007-01-01

In public health, the generation, management, and transfer of knowledge all need major improvement. Problems in generating knowledge include an imbalance in research funding, publication bias, unnecessary studies, adherence to fashion, and undue interest in novel and immediate issues. Impaired generation of knowledge, combined with a dated and inadequate process for managing knowledge and an inefficient system for transferring knowledge, mean a distorted body of evidence available for decisionmaking in public health. This article hopes to stimulate discussion by proposing a Global Registry of Anticipated Public Health Studies. This prospective, comprehensive system for tracking research in public health could help enhance collaboration and improve efficiency. Practical problems must be discussed before such a vision can be further developed. PMID:17413073

Substandard/Counterfeit Antimicrobial Drugs

PubMed Central

Kelesidis, Theodoros

2015-01-01

SUMMARY Substandard/counterfeit antimicrobial drugs are a growing global problem. The most common substandard/counterfeit antimicrobials include beta-lactams (among antibiotics) and chloroquine and artemisin derivatives (among antimalarials). The most common type of substandard/counterfeit antimicrobial drugs have a reduced amount of the active drug, and the majority of them are manufactured in Southeast Asia and Africa. Counterfeit antimicrobial drugs may cause increased mortality and morbidity and pose a danger to patients. Here we review the literature with regard to the issue of substandard/counterfeit antimicrobials and describe the prevalence of this problem, the different types of substandard/counterfeit antimicrobial drugs, and the consequences for the individuals and global public health. Local, national, and international initiatives are required to combat this very important public health issue. PMID:25788516

Limiting microbial degradation in Louisiana sugarcane mills: Are biocides effective?

USDA-ARS?s Scientific Manuscript database

Sucrose loss takes place post-harvest in sugarcane, and still represents a significant problem for the global sugar industry. In Louisiana, microorganisms cause the majority of sucrose loss during sugarcane transport to the factory, in cane piles at factory stock yards, and during overnight truck lo...

Environmental Science Misconceptions--Resolution of an Anomaly.

ERIC Educational Resources Information Center

Groves, Fred H.; Pugh, Ava F.

This document reports on research on the ability of a short-term intervention to substantially increase elementary pre-service teacher knowledge of major environmental science issues. The study was conducted each semester over seven years. Student understanding of such issues as global warming, ozone depletion, and local groundwater problems was…

Two-Dimensional Distributed Velocity Collision Avoidance

DTIC Science & Technology

2014-02-11

place (i.e., in the global problem space) as much as possible in an effort to simplify the process/description. Additionally, to make some of the...guide agents without collision in the vast majority of cases. NAWCWD TP 8786 31 7.0 REFERENCES 1. P. L. Franchi . “Near Misses Between

The economic dimension of wildland fires

Treesearch

Armando Gonzalez-Caban

2013-01-01

The economic relevance of wildland fire management and protection programs is ever growing, particularly considering mounting wildfire costs and losses globally, and the justifications required for budget allocations to management and protection of forest ecosystems. However, there are major difficulties in grappling with the problem of rapidly increasing wildland fire...

Rising atmospheric CO2 lowers food zinc, iron, and protein concentrations

USDA-ARS?s Scientific Manuscript database

Dietary deficiencies of zinc and iron are a major global public health problem. Most people who experience these deficiencies depend on agricultural crops for zinc and iron. In this context, the influence of rising concentrations of atmospheric CO2 on the availability of these nutrients from crops i...

Increasing CO2 threatens human nutrition

USDA-ARS?s Scientific Manuscript database

Dietary deficiencies of zinc and iron are a major global public health problem. An estimated two billion people suffer these deficiencies causing a loss of 63 million life years annually. Most of these people depend upon grains and legumes as their primary dietary source of zinc and iron. This manu...

Differential Outcomes in Agency-Based Mental Health Care between Minority and Majority Youth

ERIC Educational Resources Information Center

Patterson, David A.; Dulmus, Catherine N.; Maguin, Eugene; Perkins, Jacob

2016-01-01

Background: Childhood mental health problems represent a significant public health concern globally. There is a converging discussion among researchers and practitioners alike that the research results of effectiveness studies are not fully generalizable and applicable to ethnoracial minority groups in real-world practice settings. Methods:…

Cost containment for the public health.

PubMed

Eastaugh, Steven R

2006-01-01

The U.S. health care system has major problems with respect to patient access and cost control. Trimming excess hospital expenses and expanding public health activities are cost effective. By budgeting well, with global budgets set for the high cost sectors, the United States might emerge with lower tax hikes, a healthier population, better facilities, and enhanced access to service. Nations with global budgets have better health statistics, and lower costs, compared to the United States. With global budgets, these countries employ 75 to 85 percent fewer employees in administration and regulation, but patient satisfaction is almost double the rate in the United States. Implement a global budget for health care, or substantially raise taxes, is the basic choice faced in this country. Key words: global budget control cost containment.

Global-scale Ionospheric Outflow: Major Processes and Unresolved Problems

NASA Astrophysics Data System (ADS)

Liemohn, M. W.; Welling, D. T.; Ilie, R.; Khazanov, G. V.; Jahn, J. M.; Zou, S.; Ganushkina, N. Y.; Valek, P. W.; Elliott, H. A.; Gilchrist, B. E.; Hoegy, W. R.; Glocer, A.

2016-12-01

Outflow from the ionosphere is a major source of plasma to the magnetosphere. Its presence, especially that of ions heavier than He+, mass loads the magnetosphere and changes reconnection rates, current system configurations, plasma wave excitation and wave-particle interactions. It even impacts the propagation of information. We present a brief overview of the major processes and scientific history of this field. There are still major gaps, however, in our understanding of the global-scale nature of ionospheric outflow. We discuss these unresolved problems highlighting the leading questions still outstanding on this topic. First and foremost, since the measurements of ionospheric outflow have largely come from individual satellites and sounding rockets, the processes are best known on the local level, while the spatial distribution of outflow has never been simultaneously measured on more global scales. The spatial coherence and correlation of outflow across time and space have not been quantified. Furthermore, the composition of the outflow is often only measured at a coarse level of H+, He+, and O+, neglecting other species such as N+ or moleculars. However, resolving O+ from N+, as is customary in planetary research, aids in revealing the physics and altitude dependence of the energization processes in the ionosphere. Similarly, fine-resolution velocity space measurements of ionospheric outflow have been limited, yet such observations can also reveal energization processes driving the outflow. A final unresolved issue to mention is magnetically conjugate outflow and the full extent of hemispherically asymmetric outflow fluxes or fluence. Each of these open questions have substantial ramifications for magnetospheric physics; their resolution could yield sweeping changes in our understanding of nonlinear feedback and cross-scale physical interactions, magnetosphere-ionosphere coupling, and geospace system-level science.

Sexually transmitted infections: old foes on the rise.

PubMed

Carmona-Gutierrez, Didac; Kainz, Katharina; Madeo, Frank

2016-09-05

Sexually transmitted infections (STIs) are commonly spread via sexual contact. It is estimated that one million STIs are acquired every day worldwide. Besides their impact on sexual, reproductive and neonatal health, they can cause disastrous and life-threatening complications if left untreated. In addition to this personal burden, STIs also represent a socioeconomic problem, deriving in treatment costs of tremendous proportions. Despite a substantial progress in diagnosis, treatment and prevention, the incidence of many common STIs is increasing, and STIs continue to represent a global public health problem and a major cause for morbidity and mortality. With this Special Issue, Microbial Cell provides an in-depth overview of the eight major STIs, covering all relevant features of each infection.

Antarctica and global change research

NASA Astrophysics Data System (ADS)

Weller, Gunter; Lange, Manfred

1992-03-01

The Antarctic, including the continent and Southern Ocean with the subantarctic islands, is a critical area in the global change studies under the International Geosphere-Biosphere Program (IGBP) and the World Climate Research Program (WCRP). Major scientific problems include the impacts of climate warming, the ozone hole, and sea level changes. Large-scale interactions between the atmosphere, ice, ocean, and biota in the Antarctic affect the entire global system through feedbacks, biogeochemical cycles, deep-ocean circulation, atmospheric transport of heat, moisture, and pollutants, and changes in ice mass balances. Antarctica is also a rich repository of paleoenvironmental information in its ice sheet and its ocean and land sediments.

Global Equity and Justice Issues for Young People During the First Three Decades of Life.

PubMed

Petersen, Anne; Koller, Silvia H; Motti-Stefanidi, Frosso; Verma, Suman

This chapter takes a global perspective on equity and justice during development from childhood into adulthood. Globally, the population of young people is booming with the most rapid growth among young people in the poorest countries. While already faced with significant issues related to development and thriving, this population boom also exacerbates equity and justice for these children. Given this urgent situation, this chapter builds from the large body of minority world research, as well as the emergent majority world research, to argue that in order to turn the youth bulge into a demographic dividend, researchers must utilize a positive development framing rather than the more dominant problem-focused framing in studying these issues. The structural challenges confronting young people growing up in contexts marked by poverty; weak systems and institutions, especially those serving education, health, and justice; weak political and governance systems; and continual conflict must also be addressed by global and national governmental bodies. This chapter will emphasize the strengths and opportunities of the majority world, highlighting some of the strong, emergent examples of programs that support and develop the strengths of young people. We conclude with a discussion of appropriate support required from the minority and majority worlds that would further strengthen young people globally and enable them to become leaders of a more just, equitable world. © 2016 Elsevier Inc. All rights reserved.

Sustainability in a materials world

USGS Publications Warehouse

Amey, E.B.; Lemons, J.F.; Berry, Darbi R.

1996-01-01

Many adverse impacts on the environment can be directly related to the materials dispersed to the environment during processing or use, or after use as refuse and waste. Some materials, such as toxic wastes, are a major concern because they create immediate problems with longer-term effects. Gases released by major manufacturing industries can contribute to long-term regional and global problems such as acid rain or increased carbon dioxide in the atmosphere. The use of other materials, however, appears to be more benign or strictly localized in their impacts. If the current per capita level of material consumption in the United States was achieved worldwide, it would create major stresses on both resource adequacy and the environment. In fact, stresses have been created and will continue from this consumption style (developed countries) even if others don't achieve them. ?? 1996 International Association for Mathematical Geology.

Don't Get Lost in the Translation.

ERIC Educational Resources Information Center

Wederspahn, Gary M.

In this era of rapid globalization of business opportunities, many managers face the need to communicate with foreign counterparts who do not speak English. The solution, in many cases, is to use an interpreter. Interpreters, however, may make mistakes, and irritation, embarrassment and even major problems may arise from errors in translation.…

Characterization of mobile genetic elements in antibiotic resistant Salmonella enterica isolates from food animals

USDA-ARS?s Scientific Manuscript database

Antibiotic resistance (AR) is a major concern for the agricultural industry in the U.S. and globally. The problem of AR is further complicated by AR genes often being located on mobile genetic elements (MGEs) resulting in their spread among bacteria. In order to investigate the relationship between ...

Cucurbit powdery mildew of melon incited by Podosphaera xanthii: global and western U.S. perspectives

USDA-ARS?s Scientific Manuscript database

Cucurbit powdery mildew (CPM) is a major problem of melon (Cucumis melo L.) production worldwide, that is mostly caused by two fungi: Podosphaera xanthii and Golovinomyces cichoracearum (DC) V.P. Heluta (formerly Erysiphe cichoracearum). The two species may co-infect in some areas of northern Europe...

Challenging Disciplinary Boundaries in the First Year: A New Introductory Integrated Science Course for STEM Majors

ERIC Educational Resources Information Center

Gentile, Lisa; Caudill, Lester; Fetea, Mirela; Hill, April; Hoke, Kathy; Lawson, Barry; Lipan, Ovidiu; Kerckhove, Michael; Parish, Carol; Stenger, Krista; Szajda, Doug

2012-01-01

To help undergraduates make connections among disciplines so they are able to approach, evaluate, and contribute to the solutions of important global problems, our campus has been focused on interdisciplinary research and education opportunities across the science, technology, engineering, and mathematics (STEM) disciplines. This paper describes…

Environmental Education for Behaviour Change: Which Actions Should Be Targeted?

ERIC Educational Resources Information Center

Boyes, Edward; Stanisstreet, Martin

2012-01-01

One aim of environmental education is to enable people to make informed decisions about their environmental behaviour; this is particularly significant with environmental problems that are believed to be both major and imminent, such as climate change resulting from global warming. Previous research suggests no strong link between a person's…

Productivity: The New Economic Context. Worldwatch Paper 49.

ERIC Educational Resources Information Center

Newland, Kathleen

Worldwide economic productivity is examined in this paper. There are seven major sections. Section 1 is an introduction which discusses how as the seventies came to a close without producing a strong and sustained recovery from global economic recession, the spotlight of public concern focused on the problem of productivity. Trends which have…

Substandard/counterfeit antimicrobial drugs.

PubMed

Kelesidis, Theodoros; Falagas, Matthew E

2015-04-01

Substandard/counterfeit antimicrobial drugs are a growing global problem. The most common substandard/counterfeit antimicrobials include beta-lactams (among antibiotics) and chloroquine and artemisin derivatives (among antimalarials). The most common type of substandard/counterfeit antimicrobial drugs have a reduced amount of the active drug, and the majority of them are manufactured in Southeast Asia and Africa. Counterfeit antimicrobial drugs may cause increased mortality and morbidity and pose a danger to patients. Here we review the literature with regard to the issue of substandard/counterfeit antimicrobials and describe the prevalence of this problem, the different types of substandard/counterfeit antimicrobial drugs, and the consequences for the individuals and global public health. Local, national, and international initiatives are required to combat this very important public health issue. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

Ethics and allocation of health resources--the influence of poverty on health.

PubMed

Taipale, V

1999-01-01

Poverty and health are examined from the global and Nordic perspectives. The data from global social policy research, Nordic comparisons and equity in health research provide a basis for the discussion. At the global level the consequences of poverty are growing and the resultant problems posed are becoming increasingly evident. Poverty and sickness are interwoven; poverty aggravates mental problems, a situation regarding which we have seen steady deterioration. Research suggests that social cohesion, the factor that creates social capital and empowerment in societies, is a major factor that promotes health and the economy. Structural measures to combat poverty would require a global social policy: global redistribution, global regulation and global provision. However, the international community is not yet fully prepared for this discussion. At the Nordic level, Finland is a laboratory in which the viability of the welfare state has been tested in the worst recession ever to hit an OECD country. On the whole, it seems that income disparity has not grown during the recession and that services have functioned moderately well despite budget cuts. However, during that period the correlation between unemployment and sickness became apparent, and the challenges to healthcare more evident. We must make headway in untangling these relationships, because the tendency towards greater income disparity is growing in the post-recession boom. At the social welfare and health service level even the Nordic welfare states are not in full command of the means to alleviate poverty and its related health problems. Has the time come to dispel our Nordic arrogance and look at how the present services may in fact be generating inequity?

Groundwater development stress: Global-scale indices compared to regional modeling

USGS Publications Warehouse

Alley, William; Clark, Brian R.; Ely, Matt; Faunt, Claudia

2018-01-01

The increased availability of global datasets and technologies such as global hydrologic models and the Gravity Recovery and Climate Experiment (GRACE) satellites have resulted in a growing number of global-scale assessments of water availability using simple indices of water stress. Developed initially for surface water, such indices are increasingly used to evaluate global groundwater resources. We compare indices of groundwater development stress for three major agricultural areas of the United States to information available from regional water budgets developed from detailed groundwater modeling. These comparisons illustrate the potential value of regional-scale analyses to supplement global hydrological models and GRACE analyses of groundwater depletion. Regional-scale analyses allow assessments of water stress that better account for scale effects, the dynamics of groundwater flow systems, the complexities of irrigated agricultural systems, and the laws, regulations, engineering, and socioeconomic factors that govern groundwater use. Strategic use of regional-scale models with global-scale analyses would greatly enhance knowledge of the global groundwater depletion problem.

Development of Global 30m Resolution Water Body Map with Permanent/Temporal Water Body Separation Using Satellite Acquired Images of Landsat GLS Datasets

NASA Astrophysics Data System (ADS)

Ikeshima, D.; Yamazaki, D.; Yoshikawa, S.; Kanae, S.

2015-12-01

The specification of worldwide water body distribution is important for discovering hydrological cycle. Global 3-second Water Body Map (G3WBM) is a global scale map, which indicates the distribution of water body in 90m resolutions (http://hydro.iis.u-tokyo.ac.jp/~yamadai/G3WBM/index.html). This dataset was mainly built to identify the width of river channels, which is one of major uncertainties of continental-scale river hydrodynamics models. To survey the true width of the river channel, this water body map distinguish Permanent Water Body from Temporary Water Body, which means separating river channel and flood plain. However, rivers with narrower width, which is a major case in usual river, could not be observed in this map. To overcome this problem, updating the algorithm of G3WBM and enhancing the resolutions to 30m is the goal of this research. Although this 30m-resolution water body map uses similar algorithm as G3WBM, there are many technical issues attributed to relatively high resolutions. Those are such as lack of same high-resolution digital elevation map, or contamination problem of sub-pixel scale object on satellite acquired image, or invisibility of well-vegetated water body such as swamp. To manage those issues, this research used more than 30,000 satellite images of Landsat Global Land Survey (GLS), and lately distributed topography data of Shuttle Rader Topography Mission (SRTM) 1 arc-second (30m) digital elevation map. Also the effect of aerosol, which would scatter the sun reflectance and disturb the acquired result image, was considered. Due to these revises, the global water body distribution was established in more precise resolution.

Epidemiology of infections caused by multiresistant gram-negatives: ESBLs, MBLs, panresistant strains.

PubMed

Rossolini, Gian Maria; Mantengoli, Elisabetta; Docquier, Jean-Denis; Musmanno, Rosa Anna; Coratza, Grazietta

2007-07-01

Microbial drug resistance is a growing problem of global magnitude. In gram-negative pathogens, the most important resistance problems are encountered in Enterobacteriaceae, Pseudomonas aeruginosa and Acinetobacter, with increasing trends observed for all major anti-gram-negative agents (beta-lactams, fluoroquinolones and aminoglycosides). A matter of major concern is the emergence of new beta-lactamases capable of degrading the expanded-spectrum cephalosporins and/or carbapenems, such as the extended-spectrum beta-lactamases (ESBLs) and the carbapenemases. These beta-lactamase genes are often associated with resistance determinants to non-beta-lactam agents (e.g. aminoglycosides and fluoroquinolones), and strains producing ESBLs or carbapenemases often exhibit complex multidrug resistant phenotypes and sometimes are panresistant. The problem is worsened by the dearth of new agents active on multidrug-resistant Gram-negatives in the pipeline. The importance to develop better strategies to control resistance is underscored.

Salmonellosis: the role of poultry meat.

PubMed

Antunes, P; Mourão, J; Campos, J; Peixe, L

2016-02-01

Salmonellosis remains one of the most frequent food-borne zoonoses, constituting a worldwide major public health concern. Currently, at a global level, the main sources of infection for humans include meat products, including the consumption of contaminated poultry meat, in spite of the success of Salmonella control measures implemented in food-animal production of industrialized countries. In recent years, a shift in Salmonella serotypes related to poultry and poultry production has been reported in diverse geographical regions, being particularly associated with the spread of certain well-adapted clones. Moreover, antimicrobial resistance in non-typhoidal Salmonella is considered one of the major public health threats related with food-animal production, including the poultry production chain and poultry meat, which is an additional concern in the management of salmonellosis. The circulation of the same multidrug-resistant Salmonella clones and/or identical mobile genetic elements encoding antibiotic resistance genes from poultry to humans highlights this scenario. The purpose of this review was to provide an overview of the role of poultry meat on salmonellosis at a global scale and the main problems that could hinder the success of Salmonella control measures at animal production level. With the increasing globalization of foodstuffs like poultry meat, new problems and challenges might arise regarding salmonellosis control, making new integrated intervention strategies necessary along the food chain. Copyright © 2015 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

From Evidence to Policy: The Scottish National Naloxone Programme

ERIC Educational Resources Information Center

McAuley, Andrew; Best, David; Taylor, Avril; Hunter, Carole; Robertson, Roy

2012-01-01

Drug-related death (DRD) is a major public health problem globally, with rates in Scotland higher than any other UK region and among the highest in Europe. One of the most important public health interventions to emerge aimed at tackling rising DRD rates is the distribution of naloxone, the opioid antagonist, for peer administration. The Scottish…

Combating a global threat to a clonal crop: banana black sigatoka pathogen pseudocercospora fijiensis (synonym mycosphaerella fijiensis) genomes reveal clues for disease control

USDA-ARS?s Scientific Manuscript database

Mycosphaerella fijiensis is the fungal pathogen that causes black Sigatoka or leaf streak disease of banana. Control of this disease requires weekly applications of fungicides in most cultivation areas. Major problems for disease management are fungicide resistance and the lack of effective genes fo...

Vehicles for Education: Turkish Students' Beliefs and Views about Public Transport

ERIC Educational Resources Information Center

Kilinc, Ahmet; Seymen, Hatice; Malandrakis, George; Boyes, Edward; Stanisstreet, Martin

2013-01-01

The increasing use of private rather than public transport is impacting on the environment in a number of ways, including contributing to the major problem of global warming. It is necessary, therefore, to improve strategies to encourage greater use of public transport. The aim of this study is to explore which perceived aspects of public…

Trace Analysis of Heavy Metals in Ground Waters of Vijayawada Industrial Area

ERIC Educational Resources Information Center

Tadiboyina, Ravisankar; Ptsrk, Prasada Rao

2016-01-01

In recent years, the new environmental problem are arising due to industrial hazard wastage, global climate change, ground water contamination and etc., gives an attention to protect environment.one of the major source of contamination of ground water is improper discharge of industrial effluents these effluents contains so many heavy metals which…

School Nurses Avoid Addressing Child Sexual Abuse

ERIC Educational Resources Information Center

Engh Kraft, Lisbet; Rahm, GullBritt; Eriksson, Ulla-Britt

2017-01-01

Child sexual abuse (CSA) is a global public health problem with major consequences for the individual child and society. An earlier Swedish study showed that the school nurses did not initially talk about nor mention CSA as one form of child abuse. For the child to receive adequate support, the disclosure is a precondition and is dependent on an…

Designed to Move? Physical Activity Lobbying and the Politics of Productivity

ERIC Educational Resources Information Center

Piggin, Joe

2015-01-01

Objectives: Physical inactivity is a major public health concern. At a population level, it is increasingly perceived to be a social problem which is global and multidimensional, and which requires attention by a diverse range of state, private and civil society organisations. Given the increasing attention to physical in/activity by a range of…

Lyme Disease: A Sourcebook for Teaching about a Major Environmental Problem.

ERIC Educational Resources Information Center

Anderson, Norman D.; Stubbs, Harriett S.

This book and others in the Changes in the Environment Series were produced as part of the GLOBE-NET Project, a partnership of science teachers and research scientists working on various aspects of global change. This book contains up-to-date information about Lyme disease, activities for the classroom, and other resources useful in teaching about…

The potential of lentil (Lens culinaris L.) as a whole food for increased selenium, iron, and zinc intake: Preliminary results from a three year study

USDA-ARS?s Scientific Manuscript database

Micronutrient malnutrition, especially selenium (Se), iron (Fe), and zinc (Zn) deficiency, is a major global health problem. Previous attempts to prevent micronutrient malnutrition through food fortification, supplementation, and enrichment of staple crops has had limited success. Canadian grown len...

Learning without Walls: A State of Learning. Fusion 2000 Global Learning Summit (Glasgow, Scotland, September 29, 2000).

ERIC Educational Resources Information Center

Buckby, Malcolm

Information and communication technology (ICT) is an integral part of the South Australian Department of Education and Children's Services strategy to improve education and training. A major focus involves online delivery and distance education through the Internet and teacher inservice and professional development. This redresses such problems in…

Internet Therapy versus Internet Self-Help versus No Treatment for Problematic Alcohol Use: A Randomized Controlled Trial

ERIC Educational Resources Information Center

Blankers, Matthijs; Koeter, Maarten W. J.; Schippers, Gerard M.

2011-01-01

Objective: Problematic alcohol use is the third leading contributor to the global burden of disease, partly because the majority of problem drinkers are not receiving treatment. Internet-based alcohol interventions attract an otherwise untreated population, but their effectiveness has not yet been established. The current study examined the…

School Leadership in the Twenty-First Century: Different Approaches to Common Problems?

ERIC Educational Resources Information Center

Townsend, Tony

2011-01-01

This article identifies the major themes that emerge from the five selected articles in this special issue. Collectively, they demonstrate some trends occurring in the area of school leadership, but also show that individual countries are looking at these trends in different ways. It is an example of what might be called thinking globally but…

The Educational Problem That MOOCs Could Solve: Professional Development for Teachers of Disadvantaged Students

ERIC Educational Resources Information Center

Laurillard, Diana

2016-01-01

The demographics of massive open online course (MOOC) analytics show that the great majority of learners are highly qualified professionals, and not, as originally envisaged, the global community of disadvantaged learners who have no access to good higher education. MOOC pedagogy fits well with the combination of instruction and peer community…

Wood CO2 efflux in a primary tropical rain forest

Treesearch

Molly A. Cavaleri; Steven F. Oberbauer; Michael G. Ryan

2006-01-01

The balance between photosynthesis and plant respiration in tropical forests may substantially affect the global carbon cycle. Woody tissue CO2 efflux is a major component of total plant respiration, but estimates of ecosystem-scale rates are uncertain because of poor sampling in the upper canopy and across landscapes. To overcome these problems, we used a portable...

Mental health, life functioning and risk factors among people exposed to frequent natural disasters and chronic poverty in Vietnam.

PubMed

Pollack, Amie Alley; Weiss, Bahr; Trung, Lam Tu

2016-06-01

People living in low- and middle-income countries (LMIC) are at increased risk for exposure to major natural disasters, which places them at increased risk for mental health problems. Evidence is less clear, however, regarding the effects of less severe but more frequent natural disasters, which are likely to increase due to global climate change. To examine the mental health and life functioning, and their predictors, of people living in central coastal Vietnam, an area characterized by high risk for natural disasters and poverty. 1000 individuals were randomly selected from 5 provinces in central coastal Vietnam. Individuals were assessed cross-sectionally for exposure to major storms and other traumatic events (Post-traumatic Diagnostic Scale; PDS), financial stress (Chronic Financial Stress Scale), depression (PHQ-9), anxiety (GAD-7), PTSD (PDS), somatic syndrome (SCL-90-R), alcohol dependency (ICD-10), self-perceived general physical health (SF 36), and functional impairment (PDS life functioning section); caseness was determined using the various measures' algorithms. 22.7% percent of the sample ( n =227) met caseness criteria in one or more mental health domains, and 22.1% ( n =221) reported moderate to severe functional impairment. Lifetime exposure to typhoons and other major storms was 99% ( n =978), with 77% ( n =742) reporting traumatic major storm exposure. Moderate to high levels of financial stress were reported by 30% ( n =297). Frequency of exposure to major storms was not associated with increased risk for mental health problems but traumatic exposure to a major storm was. Overall, the strongest predictor of mental health problems was financial stress. Number of traumatic typhoons and other major storms in turn were significant predictors (r 2 = .03) of financial stress. The primary predictor of alcohol dependency was male gender, highlighting the importance of gender roles in development of alcohol abuse in countries like Vietnam. Individuals living in central coastal Vietnam have elevated rates of PTSD, somatic syndrome, and functional impairment but not depression or anxiety. Financial stress was the strongest predictor of mental health problems. Results suggest the importance of conducting broad assessments when providing mental health support for disaster-impacted communities. Study results suggest that one indirect consequence of predicted global climate change may be increased prevalence of mental health problems in communities such as that assessed in the present study, due to increased risk for traumatic storm-related exposure and through indirect effects on financial stress, but not through a general increased risk for major storms. Such results also indicate that when supporting LMIC communities that have experienced natural disasters, it will be important to consider the broader community context including poverty, in addition to the direct effects of the disaster.

The evolution of medical informatics in China: A retrospective study and lessons learned.

PubMed

Lei, Jianbo; Meng, Qun; Li, Yuefeng; Liang, Minghui; Zheng, Kai

2016-08-01

In contrast to China's giant health information technology (HIT) market and tremendous investments in hospital information systems the contributions of Chinese scholars in medical informatics to the global community are very limited. China would like to have a more important position in the global medical informatics community. A better understanding of the differences between medical informatics research and education in China and the discipline that emerged abroad will better inform Chinese scholars to develop right strategies to advance the field in China and help identify an appropriate means to collaborate more closely with medical informatics scholars globally. For the first time, this paper divides the evolution of medical informatics in China into four stages based on changes in the core content of research, the educational orientation and other developmental characteristics. The four stages are infancy, incubation, primary establishment and formal establishment. This paper summarizes and reviews major supporting journals and publications, as well as major organizations. Finally, we analyze the main problems that exist in the current disciplinary development in China related to medical informatics research and education and offer suggestions for future improvement. The evolution of medical informatics shows a strong and traditional concentration on medical library/bibliographic information rather than medical (hospital information or patient information) information. Misdirected-concentration, a lack of formal medical informatics trained teaching staff and mistakenly positioning medical informatics as an undergraduate discipline are some of the problems inhibiting the development of medical informatics in China. These lessons should be shared and learned for the global community. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Expanded algal cultivation can reverse key planetary boundary transgressions.

PubMed

Calahan, Dean; Osenbaugh, Edward; Adey, Walter

2018-02-01

Humanity is degrading multiple ecosystem services, potentially irreversibly. Two of the most important human impacts are excess agricultural nutrient loading in our fresh and estuarine waters and excess carbon dioxide in our oceans and atmosphere. Large-scale global intervention is required to slow, halt, and eventually reverse these stresses. Cultivating attached polyculture algae within controlled open-field photobioreactors is a practical technique for exploiting the ubiquity and high primary productivity of algae to capture and recycle the pollutants driving humanity into unsafe regimes of biogeochemical cycling, ocean acidification, and global warming. Expanded globally and appropriately distributed, algal cultivation is capable of removing excess nutrients from global environments, while additionally sequestering appreciable excess carbon. While obviously a major capital and operational investment, such a project is comparable in magnitude to the construction and maintenance of the global road transportation network. Beyond direct amelioration of critical threats, expanded algal cultivation would produce a major new commodity flow of biomass, potentially useful either as a valuable organic commodity itself, or used to reduce the scale of the problem by improving soils, slowing or reversing the loss of arable land. A 100 year project to expand algal cultivation to completely recycle excess global agricultural N and P would, when fully operational, require gross global expenses no greater than $2.3 × 10 12 yr -1 , (3.0% of the 2016 global domestic product) and less than 1.9 × 10 7 ha (4.7 × 10 7 ac), 0.38% of the land area used globally to grow food. The biomass generated embodies renewable energy equivalent to 2.8% of global primary energy production.

Looking beyond first-world problems: an emerging global workplace is encouraging more biomedical engineers to address the health issues of the developing world.

PubMed

Tucker, Lindsay

2014-01-01

Each year, the developed world is flooded with complex new medical technologies, from robotic prosthetics to remote-controlled aspirin implants. Meanwhile, only about 10% of health research funds are spent addressing the pressing problems of developing nations, although these countries make up 93% of the worldwide burden of disease. In short, while a small fraction of the world pops brand-name pharmaceuticals, the majority suffers from poor sanitation, contaminated drinking water, preventable disease, and child mortality.

Rethinking Global Water Governance for the 21st Century

NASA Astrophysics Data System (ADS)

Ajami, N. K.; Cooley, H.

2012-12-01

Growing pressure on the world's water resources is having major impacts on our social and economic well-being. According to the United Nations, today, at least 1.1 billion people do not have access to clean drinking water. Pressures on water resources are likely to continue to worsen in response to decaying and crumbling infrastructure, continued population growth, climate change, degradation of water quality, and other challenges. If these challenges are not addressed, they pose future risks for many countries around the world, making it urgent that efforts are made to understand both the nature of the problems and the possible solutions that can effectively reduce the associated risks. There is growing understanding of the need to rethink governance to meet the 21st century water challenges. More and more water problems extend over traditional national boundaries and to the global community and the types and numbers of organizations addressing water issues are large and growing. Economic globalization and transnational organizations and activities point to the need for improving coordination and integration on addressing water issues, which are increasingly tied to food and energy security, trade, global climate change, and other international policies. We will present some of the key limitations of global water governance institutions and provide recommendations for improving these institutions to address 21st century global water challenges more effectively.

Three-level global resource allocation model for hiv control: A hierarchical decision system approach.

PubMed

Kassa, Semu Mitiku

2018-02-01

Funds from various global organizations, such as, The Global Fund, The World Bank, etc. are not directly distributed to the targeted risk groups. Especially in the so-called third-world-countries, the major part of the fund in HIV prevention programs comes from these global funding organizations. The allocations of these funds usually pass through several levels of decision making bodies that have their own specific parameters to control and specific objectives to achieve. However, these decisions are made mostly in a heuristic manner and this may lead to a non-optimal allocation of the scarce resources. In this paper, a hierarchical mathematical optimization model is proposed to solve such a problem. Combining existing epidemiological models with the kind of interventions being on practice, a 3-level hierarchical decision making model in optimally allocating such resources has been developed and analyzed. When the impact of antiretroviral therapy (ART) is included in the model, it has been shown that the objective function of the lower level decision making structure is a non-convex minimization problem in the allocation variables even if all the production functions for the intervention programs are assumed to be linear.

Challenges to improvement of oral health in the 21st century--the approach of the WHO Global Oral Health Programme.

PubMed

Petersen, Poul Erik

2004-12-01

Chronic diseases and injuries are overtaking communicable diseases as the leading health problems in all but a few parts of the world. This rapidly changing global disease pattern is closely linked to changing lifestyles, which include diets rich in sugars, widespread use of tobacco and increased consumption of alcohol. These lifestyle factors also significantly impact on oral health, and oral diseases qualify as major public health problems owing to their high prevalence and incidence in all regions of the world. Like all diseases, they affect primarily the disadvantaged and socially marginalised populations, causing severe pain and suffering, impairing function and impacting on quality of life. Traditional treatment of oral diseases is extremely costly even in industrialised countries and is unaffordable in most low and middle-income countries. The WHO global strategy for prevention and control of noncommunicable diseases and the 'common risk factor approach' offer new ways of managing the prevention and control of oral diseases. This document outlines the current oral health situation and development trends at global level as well as WHO strategies and approaches for better oral health in the 21 st century.

Where next on e-waste in Australia?

PubMed

Golev, Artem; Schmeda-Lopez, Diego R; Smart, Simon K; Corder, Glen D; McFarland, Eric W

2016-12-01

For almost two decades waste electrical and electronic equipment, WEEE or e-waste, has been considered a growing problem that has global consequences. The value of recovered materials, primarily in precious and base metals, has prompted some parts of the world to informally and inappropriately process e-waste causing serious environmental and human health issues. Efforts in tackling this issue have been limited and in many ways unsuccessful. The global rates for formal e-waste treatment are estimated to be below the 20% mark, with the majority of end-of-life (EoL) electronic devices still ending up in the landfills or processed through rudimentary means. Industrial confidentiality regarding device composition combined with insufficient reporting requirements has made the task of simply characterizing the problem difficult at a global scale. To address some of these key issues, this paper presents a critical overview of existing statistics and estimations for e-waste in an Australia context, including potential value and environmental risks associated with metals recovery. From our findings, in 2014, on average per person, Australians purchased 35kg of electrical and electronic equipment (EEE) while disposed of 25kg of WEEE, and possessed approximately 320kg of EEE. The total amount of WEEE was estimated at 587kt worth about US$ 370million if all major metals are fully recovered. These results are presented over the period 2010-2014, detailed for major EEE product categories and metals, and followed by 2015-2024 forecast. Our future projection, with the base scenario fixing EEE sales at 35kg per capita, predicts stabilization of e-waste generation in Australia at 28-29kg per capita, with the total amount continuing to grow along with the population growth. Copyright © 2016 Elsevier Ltd. All rights reserved.

Global assessment of nitrogen losses and trade-offs with yields from major crop cultivations.

PubMed

Liu, Wenfeng; Yang, Hong; Liu, Junguo; Azevedo, Ligia B; Wang, Xiuying; Xu, Zongxue; Abbaspour, Karim C; Schulin, Rainer

2016-12-01

Agricultural application of reactive nitrogen (N) for fertilization is a cause of massive negative environmental problems on a global scale. However, spatially explicit and crop-specific information on global N losses into the environment and knowledge of trade-offs between N losses and crop yields are largely lacking. We use a crop growth model, Python-based Environmental Policy Integrated Climate (PEPIC), to determine global N losses from three major food crops: maize, rice, and wheat. Simulated total N losses into the environment (including water and atmosphere) are 44TgNyr -1 . Two thirds of these, or 29TgNyr -1 , are losses to water alone. Rice accounts for the highest N losses, followed by wheat and maize. The N loss intensity (NLI), defined as N losses per unit of yield, is used to address trade-offs between N losses and crop yields. The NLI presents high variation among different countries, indicating diverse N losses to produce the same amount of yields. Simulations of mitigation scenarios indicate that redistributing global N inputs and improving N management could significantly abate N losses and at the same time even increase yields without any additional total N inputs. Copyright © 2016 Elsevier B.V. All rights reserved.

Undernutrition among children in South and South-East Asia.

PubMed

Pasricha, Sant-Rayn; Biggs, Beverley-Ann

2010-09-01

Undernutrition remains a major public health problem among children living in Asia. Although the burden is maximal among poorer, rural and Indigenous communities, the problem affects the majority in many Asian countries, especially in South Asia. In order to prevent the pervasive consequences of undernutrition, strategies that address this burden are required. Successful implementation of strategies may be limited by the complex aetiology of undernutrition, including the political setting. Rising food insecurity because of climate change, land use for biofuel production and the recent global financial crisis threaten to exacerbate childhood malnutrition. In this review, we describe the burden of undernutrition among Asian children and discuss contributing factors and potential solutions. © 2010 The Authors. Journal of Paediatrics and Child Health © 2010 Paediatrics and Child Health Division (Royal Australasian College of Physicians).

Burden of non-hip, non-vertebral fractures on quality of life in postmenopausal women: the Global Longitudinal study of Osteoporosis in Women (GLOW).

PubMed

Roux, C; Wyman, A; Hooven, F H; Gehlbach, S H; Adachi, J D; Chapurlat, R D; Compston, J E; Cooper, C; Díez-Pérez, A; Greenspan, S L; Lacroix, A Z; Netelenbos, J C; Pfeilschifter, J; Rossini, M; Saag, K G; Sambrook, P N; Silverman, S; Siris, E S; Watts, N B; Boonen, S

2012-12-01

Among 50,461 postmenopausal women, 1,822 fractures occurred (57% minor non-hip, non-vertebral [NHNV], 26% major NHNV, 10% spine, 7% hip) over 1 year. Spine fractures had the greatest detrimental effect on EQ-5D, followed by major NHNV and hip fractures. Decreases in physical function and health status were greatest for spine or hip fractures. There is growing evidence that NHNV fractures result in substantial morbidity and healthcare costs. The aim of this prospective study was to assess the effect of these NHNV fractures on quality of life. We analyzed the 1-year incidences of hip, spine, major NHNV (pelvis/leg, shoulder/arm) and minor NHNV (wrist/hand, ankle/foot, rib/clavicle) fractures among women from the Global Longitudinal study of Osteoporosis in Women (GLOW). Health-related quality of life (HRQL) was analyzed using the EuroQol EQ-5D tool and the SF-36 health survey. Among 50,461 women analyzed, there were 1,822 fractures (57% minor NHNV, 26% major NHNV, 10% spine, 7% hip) over 1 year. Spine fractures had the greatest detrimental effect on EQ-5D summary scores, followed by major NHNV and hip fractures. The number of women with mobility problems increased most for those with major NHNV and spine fractures (both +8%); spine fractures were associated with the largest increases in problems with self care (+11%), activities (+14%), and pain/discomfort (+12%). Decreases in physical function and health status were greatest for those with spine or hip fractures. Multivariable modeling found that EQ-5D reduction was greatest for spine fractures, followed by hip and major/minor NHNV. Statistically significant reductions in SF-36 physical function were found for spine fractures, and were borderline significant for major NHNV fractures. This prospective study shows that NHNV fractures have a detrimental effect on HRQL. Efforts to optimize the care of osteoporosis patients should include the prevention of NHNV fractures.

The G-20 and International Economic Cooperation: Background and Implications for Congress

DTIC Science & Technology

2013-10-23

coordination among 20 major advanced and emerging- market economies.1 Originally established in 1999, the G-20 rose to prominence during the global...Gain Greater Influence Although emerging economies became more active in the international economy, particularly in financial markets starting in...crisis demonstrated that problems in the financial markets of emerging- market countries can have serious spillover

Global Oncology Volunteering: Making an Effective Contribution.

PubMed

Galassi, Annette; Pradhan, Rachna; Palat, Gayatri; LeBaron, Virginia T

2017-09-01

Elements of a good health system are lacking in most low- and middle-income countries (LMICs) and in many high-income countries, including the United States. 
A major problem is financing health care. On average, about 50% of healthcare financing in low-income countries comes from out-of-pocket payments, compared to 30% in middle-income countries and 14% in high-income countries.

Potential phosphorus eutrophication mitigation strategy: Biochar carbon composition, thermal stability and pH influence phosphorus sorption

Treesearch

L.W. Ngatia; Y.P. Hsieh; D. Nemours; R. Fu; R.W. Taylor

2017-01-01

Phosphorus (P) eutrophication is a major pollution problem globally, with unprecedented amount of P emanating from agricultural sources. But little is known about the optimization of soil-biochar P sorption capacity. The study objective was to determine how biochar feedstocks and pyrolysis conditions influences carbon (C) thermal stability, C composition and pH and in...

Liver diseases: A major, neglected global public health problem requiring urgent actions and large-scale screening.

PubMed

Marcellin, Patrick; Kutala, Blaise K

2018-02-01

CLDs represent an important, and certainly underestimated, global public health problem. CLDs are highly prevalent and silent, related to different, sometimes associated causes. The distribution of the causes of these diseases is slowly changing, and within the next decade, the proportion of virus-induced CLDs will certainly decrease significantly while the proportion of NASH will increase. There is an urgent need for effective global actions including education, prevention and early diagnosis to manage and treat CLDs, thus preventing cirrhosis-related morbidity and mortality. Our role is to increase the awareness of the public, healthcare professionals and public health authorities to encourage active policies for early management that will decrease the short- and long-term public health burden of these diseases. Because necroinflammation is the key mechanism in the progression of CLDs, it should be detected early. Thus, large-scale screening for CLDs is needed. ALT levels are an easy and inexpensive marker of liver necroinflammation and could be the first-line tool in this process. © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

A Biogeotechnical engineering approach to Combat Desertification

NASA Astrophysics Data System (ADS)

Chang, I.; Im, J.; Cho, G. C.; Lee, S. J.

2016-12-01

The acceleration of global warming is not only inducing rising sea levels and abnormal climate problems, but also geotechnical hazards such as desertification. Recently, 30% of Earth's dry land has been affected by desertification, and approximately 850 million people are suffering due to famine, poverty, and hygiene problems induced by desertification. Global warming and unsustainable land development are known to be major triggers promoting desertification. Numerous global agencies and companies are thus contributing to anti-desertification movements. However, tree planting alone is not an ideal solution given that it takes approximately 2 3 years for stabilization. It is thus imperative to develop innovative technology that can promote vegetation growth and improve soil erosion resistance. In this study, a unique soil treatment and anti-desertification method is developed using microbial biopolymers. Biopolymers can effectively strengthen soil and improve durability. In particular, anionic-hydrophilic biopolymers delay water evaporation, thereby retaining a higher soil moisture condition compared to non-treated soil. Results of this study show that microbial biopolymer treatment is highly effective in improving both vegetation growth (3 times faster) and soil erosion resistance (less than 2%), compared to untreated earth surfaces.

The role of NGOs in global health research for development

PubMed Central

Delisle, Hélène; Roberts, Janet Hatcher; Munro, Michelle; Jones, Lori; Gyorkos, Theresa W

2005-01-01

Background Global health research is essential for development. A major issue is the inequitable distribution of research efforts and funds directed towards populations suffering the world's greatest health problems. This imbalance is fostering major attempts at redirecting research to the health problems of low and middle income countries. Following the creation of the Coalition for Global Health Research – Canada (CGHRC) in 2001, the Canadian Society for International Health (CSIH) decided to review the role of non-governmental organizations (NGOs) in global health research. This paper highlights some of the prevalent thinking and is intended to encourage new thinking on how NGOs can further this role. Approach This paper was prepared by members of the Research Committee of the CSIH, with input from other members of the Society. Persons working in various international NGOs participated in individual interviews or group discussions on their involvement in different types of research activities. Case studies illustrate the roles of NGOs in global health research, their perceived strengths and weaknesses, and the constraints and opportunities to build capacity and develop partnerships for research. Highlights NGOs are contributing at all stages of the research cycle, fostering the relevance and effectiveness of the research, priority setting, and knowledge translation to action. They have a key role in stewardship (promoting and advocating for relevant global health research), resource mobilization for research, the generation, utilization and management of knowledge, and capacity development. Yet, typically, the involvement of NGOs in research is downstream from knowledge production and it usually takes the form of a partnership with universities or dedicated research agencies. Conclusion There is a need to more effectively include NGOs in all aspects of health research in order to maximize the potential benefits of research. NGOs, moreover, can and should play an instrumental role in coalitions for global health research, such as the CGHRC. With a renewed sense of purpose and a common goal, NGOs and their partners intend to make strong and lasting inroads into reducing the disease burden of the world's most affected populations through effective research action. PMID:15723694

FIAP Forum on Entrepreneurship in Physics

NASA Astrophysics Data System (ADS)

2015-03-01

With the changes in science as globalization has taken root, the future role of physicists becoming a part of the industrial physics community is more imperative. When 80% of graduating physicists will not be employed in academic positions, and 50% of all jobs for these physicists will be industrial sector, the importance of bringing our next generation of scientists up to speed on industrial applications is becoming much more important with the rapid, world-wide development of technology. FIAP is initiating a forum on entrepreneurship as a major role for the next generation of scientists. As physicists are problem solvers and the entrepreneurial experience is all about problem solving: whether involving technology, building a team, or financing a business. This forum seeks to link successful entrepreneurial physicists with the upcoming generation, through the dissemination of their global expertise and experience. The forum will consist of a panel discussion and then be open to question and answers from the audience.

Malnutrition and disability: unexplored opportunities for collaboration

PubMed Central

Groce, N; Challenger, E; Berman-Bieler, R; Farkas, A; Yilmaz, N; Schultink, W; Clark, D; Kaplan, C; Kerac, M

2014-01-01

There is increasing international interest in the links between malnutrition and disability: both are major global public health problems, both are key human rights concerns, and both are currently prominent within the global health agenda. In this review, interactions between the two fields are explored and it is argued that strengthening links would lead to important mutual benefits and synergies. At numerous points throughout the life-cycle, malnutrition can cause or contribute to an individual’s physical, sensory, intellectual or mental health disability. By working more closely together, these problems can be transformed into opportunities: nutrition services and programmes for children and adults can act as entry points to address and, in some cases, avoid or mitigate disability; disability programmes can improve nutrition for the children and adults they serve. For this to happen, however, political commitment and resources are needed, as are better data. PMID:25309998

A review of global outlook on fluoride contamination in groundwater with prominence on the Pakistan current situation.

PubMed

Rasool, Atta; Farooqi, Abida; Xiao, Tangfu; Ali, Waqar; Noor, Sifat; Abiola, Oyebamiji; Ali, Salar; Nasim, Wajid

2017-12-19

Several million people are exposed to fluoride (F - ) via drinking water in the world. Current review emphasized the elevated level of fluoride concentrations in the groundwater and associated potential health risk globally with a special focus on Pakistan. Millions of people are deeply dependent on groundwater from different countries of the world encompassing with an elevated level of fluoride. The latest estimates suggest that around 200 million people, from among 25 nations the world over, are under the dreadful fate of fluorosis. India and China, the two most populous countries of the world, are the worst affected. In Pakistan, fluoride data of 29 major cities are reviewed and 34% of the cities show fluoride levels with a mean value greater than 1.5 mg/L where Lahore, Quetta and Tehsil Mailsi are having the maximum values of 23.60, 24.48, > 5.5 mg/L, respectively. In recent years, however, other countries have minimized, even eliminated its use due to health issues. High concentration of fluoride for extended time period causes adverse effects of health such as skin lesions, discoloration, cardiovascular disorders, dental fluorosis and crippling skeletal fluorosis. This review deliberates comprehensive strategy of drinking water quality in the global scenario of fluoride contamination, especially in Pakistan with prominence on major pollutants, mitigation technologies, sources of pollution and ensuing health problems. Considering these verities, health authorities urgently need to establish alternative means of water decontamination in order to prevent associated health problems.

Strengthening International Collaboration: Geosciences Research and Education in Developing Countries

NASA Astrophysics Data System (ADS)

Fucugauchi, J. U.

2009-05-01

Geophysical research increasingly requires global multidisciplinary approaches and global integration. Global warming, increasing CO2 levels and increased needs of mineral and energy resources emphasize impact of human activities. The planetary view of our Earth as a deeply complex interconnected system also emphasizes the need of international scientific cooperation. International collaboration presents an immense potential and is urgently needed for further development of geosciences research and education. In analyzing international collaboration a relevant aspect is the role of scientific societies. Societies organize meetings, publish journals and books and promote cooperation through academic exchange activities and can further assist communities in developing countries providing and facilitating access to scientific literature, attendance to international meetings, short and long-term stays and student and young researcher mobility. Developing countries present additional challenges resulting from limited economic resources and social and political problems. Most countries urgently require improved educational and research programs. Needed are in-depth analyses of infrastructure and human resources and identification of major problems and needs. Questions may include what are the major limitations and needs in research and postgraduate education in developing countries? what and how should international collaboration do? and what are the roles of individuals, academic institutions, funding agencies, scientific societies? Here we attempt to examine some of these questions with reference to case examples and AGU role. We focus on current situation, size and characteristics of research community, education programs, facilities, economic support, and then move to perspectives for potential development in an international context.

GPU Multi-Scale Particle Tracking and Multi-Fluid Simulations of the Radiation Belts

NASA Astrophysics Data System (ADS)

Ziemba, T.; Carscadden, J.; O'Donnell, D.; Winglee, R.; Harnett, E.; Cash, M.

2007-12-01

The properties of the radiation belts can vary dramatically under the influence of magnetic storms and storm-time substorms. The task of understanding and predicting radiation belt properties is made difficult because their properties determined by global processes as well as small-scale wave-particle interactions. A full solution to the problem will require major innovations in technique and computer hardware. The proposed work will demonstrates liked particle tracking codes with new multi-scale/multi-fluid global simulations that provide the first means to include small-scale processes within the global magnetospheric context. A large hurdle to the problem is having sufficient computer hardware that is able to handle the dissipate temporal and spatial scale sizes. A major innovation of the work is that the codes are designed to run of graphics processing units (GPUs). GPUs are intrinsically highly parallelized systems that provide more than an order of magnitude computing speed over a CPU based systems, for little more cost than a high end-workstation. Recent advancements in GPU technologies allow for full IEEE float specifications with performance up to several hundred GFLOPs per GPU and new software architectures have recently become available to ease the transition from graphics based to scientific applications. This allows for a cheap alternative to standard supercomputing methods and should increase the time to discovery. A demonstration of the code pushing more than 500,000 particles faster than real time is presented, and used to provide new insight into radiation belt dynamics.

Are you sitting comfortably? The political economy of the body.

PubMed

Wilkin, Peter

2009-01-01

The aim of this paper is to examine the relationship between the mass production of furniture in modern industrial societies and lower back pain (LBP). The latter has proven to be a major cost to health services and private industry throughout the industrialised world and now represents a global health issue as recent WHO reports on obesity and LBP reveal. Thus far there have been few co-ordinated attempts to deal with the causes of the problem through public policy. Drawing upon a range of sources in anthropology, health studies, politics and economics, the paper argues that this a modern social problem rooted in the contingent conjuncture of natural and social causal mechanisms. The key question it raises is: what are the appropriate mechanisms for addressing this problem? This paper develops an analysis rooted in libertarian social theory and argues that both the state and the capitalist market are flawed mechanisms for resolving this problem. There remains a fundamental dilemma for libertarians, however. Whilst the state and the market may well be flawed mechanisms, they are the dominant ones shaping global political economy. To what extent can libertarians work within these structures and remain committed to libertarian goals?

The burden of musculoskeletal disease in Sierra Leone.

PubMed

Elliott, Iain S; Groen, Reinou S; Kamara, Thaim B; Ertl, Allison; Cassidy, Laura D; Kushner, Adam L; Gosselin, Richard A

2015-01-01

Musculoskeletal disease is a major cause of disability in the global burden of disease, yet data regarding the magnitude of this burden in developing countries are lacking. The Surgeons OverSeas Assessment of Surgical Need (SOSAS) survey was designed to measure the incidence and prevalence of surgically treatable conditions, including musculoskeletal conditions, in patients in low- and middle-income countries, and was administered in the West African nation of Sierra Leone in 2012. We attempted to quantify the burden of potentially treatable musculoskeletal conditions in patients in Sierra Leone. A cross-sectional two-stage cluster-based survey was performed in Sierra Leone using the SOSAS. Two individuals from each randomly selected household underwent a verbal head to toe examination. The musculoskeletal-related questions from the SOSAS survey in Sierra Leone were analyzed to determine the prevalence of musculoskeletal problems in the study population. Prevalence is reported as the number of respondents with a musculoskeletal problem now and number of respondents with a musculoskeletal problem during the past year. Respondents had "no need" for care, they "received care", or they faced a barrier that prevented them from receiving care. One thousand eight hundred seventy-five households were targeted, with 1843 undergoing the survey, which yielded 3645 individual respondents. Of the individual respondents, 462 (n=3645; 12.6% of total; 95% CI, 12%-13%) had a traumatic musculoskeletal problem during the past year, and 236 (n=3645; 6% of total; 95% CI, 5%-7%) respondents had a musculoskeletal problem of nontraumatic etiology. Of respondents with either a traumatic or nontraumatic musculoskeletal problem, 359 (n=562; 63.9% of total; 95% CI, 59.5-68.3%) needed care but were unable to receive it with the major barrier reported as financial. Resource allocation decisions in global health are made based on burden of disease data in low- and middle-income countries. The data provided here for Sierra Leone may offer some generalizable insight into the scope of the burden of musculoskeletal disease for low- and middle-income countries, especially in Sub-Saharan Africa, and provide concrete evidence that musculoskeletal health should be included in the global health discussion. However, there may be important differences across countries in this region, and further study to elucidate these differences seems critical given the large burden of disease and the limited resources available in these regions to manage it.

SIAM conference on inverse problems: Geophysical applications. Final technical report

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1995-12-31

This conference was the second in a series devoted to a particular area of inverse problems. The theme of this series is to discuss problems of major scientific importance in a specific area from a mathematical perspective. The theme of this symposium was geophysical applications. In putting together the program we tried to include a wide range of mathematical scientists and to interpret geophysics in as broad a sense as possible. Our speaker came from industry, government laboratories, and diverse departments in academia. We managed to attract a geographically diverse audience with participation from five continents. There were talks devotedmore » to seismology, hydrology, determination of the earth`s interior on a global scale as well as oceanographic and atmospheric inverse problems.« less

Proceedings of the second US-USSR symposium: air pollution effects on vegetation including forest ecosystems

Treesearch

Reginald D. Noble; Juri L Martin; Keith F., eds. Jensen; Keith F. Jensen

1989-01-01

To commemorate the 10th year of cooperation between the US-USSR in the field of environmental protection, a symposium was organized, the major objectives of which were to acquaint US-USSR scientists with project accomplishments; to promote understanding of the nature of environmental problems that relate to air pollution effect on vegetation on a more global scale; to...

Changes and Threats to the Employee Development under Social and Economic Conditions within Global Labour Market

ERIC Educational Resources Information Center

Sikora, Jan

2014-01-01

The main theme of the article is the thesis that man's engagement in the process of professional work is engaged in a number of antinomies. The problem of contemporary economics has been analyzed. It has been revealed that situation in which the majority of people excluded from social debate due to their lack of competences become a useful medium…

Global issues in women's health.

PubMed

Sciarra, John J

2009-01-01

World population growth in the past century has taxed the ability of healthcare systems in low-income countries to provide reproductive health care. Maternal mortality and morbidity, sexually transmitted diseases, and cervical cancer are major problems. Expansion of reproductive health services, training of appropriate medical personnel, and elevating the status of women in society are all necessary and appropriate solutions to improve the health of women in low-income countries.

Racial Socialization, Private Regard, and Behavior Problems in African American Youth: Global Self-Esteem as a Mediator

PubMed Central

Davis, BreAnna L.; Smith-Bynum, Mia A.; Saleem, Farzana T.; Francois, Tiffany; Lambert, Sharon F.

2017-01-01

Racial socialization messages appear to have varying impacts on the adjustment of African American youth. To further explore this, we examined how two types of racial socialization messages might influence African American youth internalizing and externalizing behavior. The Youth Self Report was used to measure these behavior outcomes. Given that racial socialization messages may not be directly linked to behavior outcomes, we considered private regard, an aspect of racial identity, to serve as a mediator. Additionally, we examined global self-esteem as a mediator of the complex dynamic between racial socialization messages and behavior outcomes. Adolescents in our study completed paper assessments. Majority of the participants were female (56 %) and reside in a metropolitan area in the Mid-Atlantic region. Adolescent’s ages ranged from 14 to 17 years with the average age being 15 years old. Path analysis revealed cultural pride and alertness to discrimination messages varied in their relation to private regard. Results also indicated a strong linkage between private regard, global self-esteem, and internalizing behaviors. Interestingly, the linkage between private regard, global self-esteem and externalizing behaviors was not as robust. Further, private regard appeared to directly and indirectly impact externalizing behaviors. The implications of these findings for racial socialization strategies, identity development (racial and global) as it pertains to behavior problems for African American adolescents are discussed. PMID:28546737

E-Waste and Harm to Vulnerable Populations: A Growing Global Problem.

PubMed

Heacock, Michelle; Kelly, Carol Bain; Asante, Kwadwo Ansong; Birnbaum, Linda S; Bergman, Åke Lennart; Bruné, Marie-Noel; Buka, Irena; Carpenter, David O; Chen, Aimin; Huo, Xia; Kamel, Mostafa; Landrigan, Philip J; Magalini, Federico; Diaz-Barriga, Fernando; Neira, Maria; Omar, Magdy; Pascale, Antonio; Ruchirawat, Mathuros; Sly, Leith; Sly, Peter D; Van den Berg, Martin; Suk, William A

2016-05-01

Electronic waste (e-waste) is produced in staggering quantities, estimated globally to be 41.8 million tonnes in 2014. Informal e-waste recycling is a source of much-needed income in many low- to middle-income countries. However, its handling and disposal in underdeveloped countries is often unsafe and leads to contaminated environments. Rudimentary and uncontrolled processing methods often result in substantial harmful chemical exposures among vulnerable populations, including women and children. E-waste hazards have not yet received the attention they deserve in research and public health agendas. We provide an overview of the scale and health risks. We review international efforts concerned with environmental hazards, especially affecting children, as a preface to presenting next steps in addressing health issues stemming from the global e-waste problem. The e-waste problem has been building for decades. Increased observation of adverse health effects from e-waste sites calls for protecting human health and the environment from e-waste contamination. Even if e-waste exposure intervention and prevention efforts are implemented, legacy contamination will remain, necessitating increased awareness of e-waste as a major environmental health threat. Global, national, and local levels efforts must aim to create safe recycling operations that consider broad security issues for people who rely on e-waste processing for survival. Paramount to these efforts is reducing pregnant women and children's e-waste exposures to mitigate harmful health effects. With human environmental health in mind, novel dismantling methods and remediation technologies and intervention practices are needed to protect communities. Heacock M, Kelly CB, Asante KA, Birnbaum LS, Bergman AL, Bruné MN, Buka I, Carpenter DO, Chen A, Huo X, Kamel M, Landrigan PJ, Magalini F, Diaz-Barriga F, Neira M, Omar M, Pascale A, Ruchirawat M, Sly L, Sly PD, Van den Berg M, Suk WA. 2016. E-waste and harm to vulnerable populations: a growing global problem. Environ Health Perspect 124:550-555; http://dx.doi.org/10.1289/ehp.1509699.

Calvarial tuberculosis presenting as cystic lesion: An unusual presentation in two patients.

PubMed

Khare, Pratima; Gupta, Renu; Chand, Priyanka; Agarwal, Swapnil

2015-01-01

Tuberculosis is a common disease in developing countries such as India, posing a major public health problem. With human immunodeficiency virus (HIV) infection being a global endemic, there has been a resurgence of tuberculosis even in developed countries. Tuberculosis may affect almost any part of the body. However, tuberculosis of the calvarium is very rare. Presentation of tuberculosis as a soft tissue swelling on the scalp poses a diagnostic problem. These two cases are being reported here to convey the utility of fine-needle aspiration cytology (FNAC) in providing the confirmatory diagnosis obviating the need for invasive surgical procedure.

The global threat of antimicrobial resistance: science for intervention

PubMed Central

Roca, I.; Akova, M.; Baquero, F.; Carlet, J.; Cavaleri, M.; Coenen, S.; Cohen, J.; Findlay, D.; Gyssens, I.; Heure, O.E.; Kahlmeter, G.; Kruse, H.; Laxminarayan, R.; Liébana, E.; López-Cerero, L.; MacGowan, A.; Martins, M.; Rodríguez-Baño, J.; Rolain, J.-M.; Segovia, C.; Sigauque, B.; Taconelli, E.; Wellington, E.; Vila, J.

2015-01-01

In the last decade we have witnessed a dramatic increase in the proportion and absolute number of bacterial pathogens resistant to multiple antibacterial agents. Multidrug-resistant bacteria are currently considered as an emergent global disease and a major public health problem. The B-Debate meeting brought together renowned experts representing the main stakeholders (i.e. policy makers, public health authorities, regulatory agencies, pharmaceutical companies and the scientific community at large) to review the global threat of antibiotic resistance and come up with a coordinated set of strategies to fight antimicrobial resistance in a multifaceted approach. We summarize the views of the B-Debate participants regarding the current situation of antimicrobial resistance in animals and the food chain, within the community and the healthcare setting as well as the role of the environment and the development of novel diagnostic and therapeutic strategies, providing expert recommendations to tackle the global threat of antimicrobial resistance. PMID:26029375

Smoothing of cost function leads to faster convergence of neural network learning

NASA Astrophysics Data System (ADS)

Xu, Li-Qun; Hall, Trevor J.

1994-03-01

One of the major problems in supervised learning of neural networks is the inevitable local minima inherent in the cost function f(W,D). This often makes classic gradient-descent-based learning algorithms that calculate the weight updates for each iteration according to (Delta) W(t) equals -(eta) (DOT)$DELwf(W,D) powerless. In this paper we describe a new strategy to solve this problem, which, adaptively, changes the learning rate and manipulates the gradient estimator simultaneously. The idea is to implicitly convert the local- minima-laden cost function f((DOT)) into a sequence of its smoothed versions {f(beta t)}Ttequals1, which, subject to the parameter (beta) t, bears less details at time t equals 1 and gradually more later on, the learning is actually performed on this sequence of functionals. The corresponding smoothed global minima obtained in this way, {Wt}Ttequals1, thus progressively approximate W-the desired global minimum. Experimental results on a nonconvex function minimization problem and a typical neural network learning task are given, analyses and discussions of some important issues are provided.

Improving Global Kidney Health: International Society of Nephrology Initiatives and the Global Kidney Health Atlas.

PubMed

Levin, Adeera

2018-01-01

Chronic Kidney Disease (CKD) is a major public health problem and is increasingly being recognized as an important driver of costs in all health care systems. The diversity of outcomes for people living with CKD is in part due to variability in biology, access to care, environmental factors, and health care system differences. The International Society of Nephrology (ISN), working in collaboration with its partners, has evolved into a philanthropic organization, from a traditional medical society, committed to a vision that sees "a future where all people have access to sustainable kidney health". A set of activities, including a Global Kidney Health Summit, the Global Kidney Health Atlas, and a Global Kidney Health Policy Forum, which has formed the basis of a multi-stakeholder engagement process, building on a solid base of ISN programs and educational activities, is described. Through building awareness and increasing capacity to conduct research, the international community will build a more solid foundation on which to advocate for sustainable, ethical solutions to the problem of kidney disease throughout the world. The ISN aims to improve kidney health worldwide through a variety of diverse activities addressing education, advocacy, and research. Collaboration with partners within and outside the medical community is key in achieving this goal. Key Messages: Kidney disease is an important public health problem and is driven by genetic, environmental, and socioeconomic factors. Through active collaboration with diverse partners, the international community is striving for sustainable kidney health and aims to achieve this through coordinated work in a variety of spheres. © 2018 The Author(s) Published by S. Karger AG, Basel.

IMPLEMENTATION OF GASTRIC CANCER SCREENING – THE GLOBAL EXPERIENCE

PubMed Central

Leja, Mārcis; You, Weicheng; Camargo, M. Constanza; Saito, Hiroshi

2018-01-01

Gastric cancer (GC) is still an important global healthcare problem, and in absolute figures it is going to remain at the present level in foreseeable future. In general, survival of patients with GC is poor mainly due to advanced-stage diagnosis. Early-stage GC can be cured by endoscopic resection or less invasive surgical treatment. Unfortunately, there is no appropriate screening strategy available for global application. This article provides a description of established national and regional GC screening programs and the screening modalities used. This review also summarizes current approaches to develop cancer-screening biomarkers. Although candidates with initial promising results have been suggested, moving discovery into clinical practice is still a major challenge. Well-designed biomarker studies, with systematic validation steps, are needed to decrease the burden of this fatal disease. PMID:25439074

A strategy for Earth science from space in the 1980s. Part 1: Solid earth and oceans

NASA Technical Reports Server (NTRS)

1982-01-01

The report develops a ten-year science strategy for investigating the solid earth and dynamics of world oceans from Earth orbit. The strategy begins from the premise that earth studies have proceeded to the point where further advances in understanding Earth processes must be based on a global perspective and that the U.S. is technically ready to begin a global study approach from Earth orbit. The major areas of study and their fundamental problems are identified. The strategy defines the primary science objectives to be addressed and the essential measurements and precision to achieve them.

Zoonotic Parasites of Sheltered and Stray Dogs in the Era of the Global Economic and Political Crisis.

PubMed

Otranto, Domenico; Dantas-Torres, Filipe; Mihalca, Andrei D; Traub, Rebecca J; Lappin, Michael; Baneth, Gad

2017-10-01

Sheltered and stray dogs, exposed to zoonotic parasites, including protozoa, helminths, and arthropods, may represent a major threat to public health. Resources for addressing health problems in these animals are not on the priority list of veterinary and public health authorities. Thus, dogs continue to represent an important reservoir for zoonotic parasites. In this article, we review the importance of sheltered and stray dogs as reservoirs of zoonotic parasites in different parts of the world, especially in the context of the current global political and economic crisis. Copyright © 2017 Elsevier Ltd. All rights reserved.

Time to tackle clonorchiasis in China

PubMed Central

2013-01-01

Recent publication of the global epidemiology of clonorchiasis and its relationship with cholangiocarcinoma in the journal of Infectious Diseases of Poverty has stressed the importance of Clonorchis sinensis infection. To further demonstrate its threat on public health, especially in China, comparisons between clonorchiasis and hepatitis B are made in terms of epidemiology, clinical symptoms and carcinogenicity, disability, as well as changing trends. Furthermore, major problems and prioritized researches are argued, from basic biology to intervention. Imbalance between the majority of infected population and the minority of researches in China urges for more work from Chinese scientists and international cooperation. PMID:23849773

Ciguatera fish poisoning: a first epidemic in Germany highlights an increasing risk for European countries.

PubMed

Mattei, César; Vetter, Irina; Eisenblätter, Anneka; Krock, Bernd; Ebbecke, Martin; Desel, Herbert; Zimmermann, Katharina

2014-12-01

Toxin-producing microalgae are thriving worldwide due to coral reef destruction and global warming with major consequences on ecosystems, international trade and human health. Microalgae belonging to the family of flagellate protists, in particular dinoflagellates, secrete a variety of high-molecular-weight polyether toxins that accumulate through the marine food chain to cause disease in humans by acting as sodium channel activator toxins; ciguatera is the most frequent seafood-borne illness worldwide with 50,000 to 500,000 global incidences per annum and is usually limited to endemic areas located between 35° northern and 35° southern latitude. The rising global incidence frequency renders it a major human health problem, because no curative treatment is available yet and reliable detection assays are lacking. During the last decade ciguatera has increasingly become endemic in previously unaffected areas for two reasons: first global warming has contributed to the emergence of dinoflagellate species in subtropical and even temperate regions that previously had been constrained to tropical areas and second: in Europe globalization of fishing industry and tourism has led to a progressive increase in the number of ciguatera cases and a lack of awareness among medical personnel contributes to under-reporting. We review, through a recent ciguatera outbreak in Germany, the risk for ciguatera poisoning in Europe and highlight characteristic symptoms, current knowledge about disease pathomechanisms and treatment options.

African Orphan Crops under Abiotic Stresses: Challenges and Opportunities.

PubMed

Tadele, Zerihun

2018-01-01

A changing climate, a growing world population, and a reduction in arable land devoted to food production are all problems facing the world food security. The development of crops that can yield under uncertain and extreme climatic and soil growing conditions can play a key role in mitigating these problems. Major crops such as maize, rice, and wheat are responsible for a large proportion of global food production but many understudied crops (commonly known as "orphan crops") including millets, cassava, and cowpea feed millions of people in Asia, Africa, and South America and are already adapted to the local environments in which they are grown. The application of modern genetic and genomic tools to the breeding of these crops can provide enormous opportunities for ensuring world food security but is only in its infancy. In this review, the diversity and types of understudied crops will be introduced, and the beneficial traits of these crops as well as their role in the socioeconomics of Africa will be discussed. In addition, the response of orphan crops to diverse types of abiotic stresses is investigated. A review of the current tools and their application to the breeding of enhanced orphan crops will also be described. Finally, few examples of global efforts on tackling major abiotic constraints in Africa are presented.

African Orphan Crops under Abiotic Stresses: Challenges and Opportunities

PubMed Central

2018-01-01

A changing climate, a growing world population, and a reduction in arable land devoted to food production are all problems facing the world food security. The development of crops that can yield under uncertain and extreme climatic and soil growing conditions can play a key role in mitigating these problems. Major crops such as maize, rice, and wheat are responsible for a large proportion of global food production but many understudied crops (commonly known as “orphan crops”) including millets, cassava, and cowpea feed millions of people in Asia, Africa, and South America and are already adapted to the local environments in which they are grown. The application of modern genetic and genomic tools to the breeding of these crops can provide enormous opportunities for ensuring world food security but is only in its infancy. In this review, the diversity and types of understudied crops will be introduced, and the beneficial traits of these crops as well as their role in the socioeconomics of Africa will be discussed. In addition, the response of orphan crops to diverse types of abiotic stresses is investigated. A review of the current tools and their application to the breeding of enhanced orphan crops will also be described. Finally, few examples of global efforts on tackling major abiotic constraints in Africa are presented. PMID:29623231

GLOBEC: Global Ocean Ecosystems Dynamics: A component of the US Global Change Research Program

NASA Technical Reports Server (NTRS)

1991-01-01

GLOBEC (GLOBal ocean ECosystems dynamics) is a research initiative proposed by the oceanographic and fisheries communities to address the question of how changes in global environment are expected to affect the abundance and production of animals in the sea. The approach to this problem is to develop a fundamental understanding of the mechanisms that determine both the abundance of key marine animal populations and their variances in space and time. The assumption is that the physical environment is a major contributor to patterns of abundance and production of marine animals, in large part because the planktonic life stages typical of most marine animals are intrinsically at the mercy of the fluid motions of the medium in which they live. Consequently, the authors reason that a logical approach to predicting the potential impact of a globally changing environment is to understand how the physical environment, both directly and indirectly, contributes to animal abundance and its variability in marine ecosystems. The plans for this coordinated study of of the potential impact of global change on ocean ecosystems dynamics are discussed.

An analysis of global problem issues in sixth-and seventh-grade textbooks

NASA Astrophysics Data System (ADS)

Hamm, Mary; Adams, Dennis

The study examines the extent to which the global issues of population growth, world hunger, air quality and atmosphere, and water resources were treated in sixth- and seventh-grade science textbooks. Ten textbooks were examined by five raters to determine the amount of content presented by different textbooks on global issues, the number of pages of content devoted to each issue, and the degree of depth in which issues were treated. Differences between grade levels were also explored. Of the 4,393 pages of content analyzed, less than 2 percent was devoted to these issues identified as the most serious human problems. No significant differences were found between textbook series. Significant differences were found in the number of pages of content presented on each issue. Most of the content fell into the categories of water resources, population growth, air quality, and atmosphere. The issue of war technology had the least amount of content. Distribution of content did not vary by grade level. Both levels addressed the issues of population growth, air quality, and water resources with a greater degree of depth than the issue of world hunger or war technology. The study concludes that the most widely used textbooks at the sixth- and seventh-grade levels avoid serious discussion of major global problems. And like the career indecision of a recent Miss America contestant, purchasers don't seem to be able to decide whether they want science textbooks to be a brain surgeon or a movie actress. Implications stemming from this dichotomy and its relationship to future science education curricular are also explored.

Global Surgery 2030: a roadmap for high income country actors.

PubMed

Ng-Kamstra, Joshua S; Greenberg, Sarah L M; Abdullah, Fizan; Amado, Vanda; Anderson, Geoffrey A; Cossa, Matchecane; Costas-Chavarri, Ainhoa; Davies, Justine; Debas, Haile T; Dyer, George S M; Erdene, Sarnai; Farmer, Paul E; Gaumnitz, Amber; Hagander, Lars; Haider, Adil; Leather, Andrew J M; Lin, Yihan; Marten, Robert; Marvin, Jeffrey T; McClain, Craig D; Meara, John G; Meheš, Mira; Mock, Charles; Mukhopadhyay, Swagoto; Orgoi, Sergelen; Prestero, Timothy; Price, Raymond R; Raykar, Nakul P; Riesel, Johanna N; Riviello, Robert; Rudy, Stephen M; Saluja, Saurabh; Sullivan, Richard; Tarpley, John L; Taylor, Robert H; Telemaque, Louis-Franck; Toma, Gabriel; Varghese, Asha; Walker, Melanie; Yamey, Gavin; Shrime, Mark G

2016-01-01

The Millennium Development Goals have ended and the Sustainable Development Goals have begun, marking a shift in the global health landscape. The frame of reference has changed from a focus on 8 development priorities to an expansive set of 17 interrelated goals intended to improve the well-being of all people. In this time of change, several groups, including the Lancet Commission on Global Surgery, have brought a critical problem to the fore: 5 billion people lack access to safe, affordable surgical and anaesthesia care when needed. The magnitude of this problem and the world's new focus on strengthening health systems mandate reimagined roles for and renewed commitments from high income country actors in global surgery. To discuss the way forward, on 6 May 2015, the Commission held its North American launch event in Boston, Massachusetts. Panels of experts outlined the current state of knowledge and agreed on the roles of surgical colleges and academic medical centres; trainees and training programmes; academia; global health funders; the biomedical devices industry, and news media and advocacy organisations in building sustainable, resilient surgical systems. This paper summarises these discussions and serves as a consensus statement providing practical advice to these groups. It traces a common policy agenda between major actors and provides a roadmap for maximising benefit to surgical patients worldwide. To close the access gap by 2030, individuals and organisations must work collectively, interprofessionally and globally. High income country actors must abandon colonial narratives and work alongside low and middle income country partners to build the surgical systems of the future.

Global Surgery 2030: a roadmap for high income country actors

PubMed Central

Greenberg, Sarah L M; Abdullah, Fizan; Amado, Vanda; Anderson, Geoffrey A; Cossa, Matchecane; Costas-Chavarri, Ainhoa; Davies, Justine; Debas, Haile T; Dyer, George S M; Erdene, Sarnai; Farmer, Paul E; Gaumnitz, Amber; Hagander, Lars; Haider, Adil; Leather, Andrew J M; Lin, Yihan; Marten, Robert; Marvin, Jeffrey T; McClain, Craig D; Meara, John G; Meheš, Mira; Mock, Charles; Mukhopadhyay, Swagoto; Orgoi, Sergelen; Prestero, Timothy; Price, Raymond R; Raykar, Nakul P; Riesel, Johanna N; Riviello, Robert; Rudy, Stephen M; Saluja, Saurabh; Sullivan, Richard; Tarpley, John L; Taylor, Robert H; Telemaque, Louis-Franck; Toma, Gabriel; Varghese, Asha; Walker, Melanie; Yamey, Gavin; Shrime, Mark G

2016-01-01

The Millennium Development Goals have ended and the Sustainable Development Goals have begun, marking a shift in the global health landscape. The frame of reference has changed from a focus on 8 development priorities to an expansive set of 17 interrelated goals intended to improve the well-being of all people. In this time of change, several groups, including the Lancet Commission on Global Surgery, have brought a critical problem to the fore: 5 billion people lack access to safe, affordable surgical and anaesthesia care when needed. The magnitude of this problem and the world's new focus on strengthening health systems mandate reimagined roles for and renewed commitments from high income country actors in global surgery. To discuss the way forward, on 6 May 2015, the Commission held its North American launch event in Boston, Massachusetts. Panels of experts outlined the current state of knowledge and agreed on the roles of surgical colleges and academic medical centres; trainees and training programmes; academia; global health funders; the biomedical devices industry, and news media and advocacy organisations in building sustainable, resilient surgical systems. This paper summarises these discussions and serves as a consensus statement providing practical advice to these groups. It traces a common policy agenda between major actors and provides a roadmap for maximising benefit to surgical patients worldwide. To close the access gap by 2030, individuals and organisations must work collectively, interprofessionally and globally. High income country actors must abandon colonial narratives and work alongside low and middle income country partners to build the surgical systems of the future. PMID:28588908

Integrative endeavor for renaissance in Ayurveda

PubMed Central

Raut, Ashwinikumar A.

2011-01-01

Currently western medicine has assumed the central position in mainstream global healthcare. Openness to learn from contemporary disciplines of basic sciences, application of modern technology and further adoption of the evidence-based approach has helped western medicine gain its currently acknowledged position as mainstream modern medicine. Modern medicine has further developed forms of integrative medicine by developing interfaces with other systems of medicine, including traditional, complementary and alternative medicine. However, these developments do not seem to address all the problems facing global health care caused by overemphasis on pharmaco-therapeutic drug developments. On the other hand, Ayurveda which is founded on genuine fundamentals, has the longest uninterrupted tradition of healthcare practice, and its holistic approach to healthcare management emphasizes disease prevention and health promotion; if it opens up to incorporate emerging new knowledge into mainstream Ayurveda, and maintains fidelity to Ayurveda fundamentals, it will certainly provide a broad-based opportunity to address the majority of the problems that have emerged from global healthcare requirements. To bring these solutions to bear, however, it will be necessary to progress from the present “utilitarian ethos” to a “unifying ethos” for realization of medical integration. PMID:21731380

Emergence and dissemination of antibiotic resistance: a global problem.

PubMed

Choudhury, R; Panda, S; Singh, D V

2012-01-01

Antibiotic resistance is a major problem in clinical health settings. Interestingly the origin of many of antibiotic resistance mechanisms can be traced back to non-pathogenic environmental organisms. Important factors leading to the emergence and spread of antibiotic resistance include absence of regulation in the use of antibiotics, improper waste disposal and associated transmission of antibiotic resistance genes in the community through commensals. In this review, we discussed the impact of globalisation on the transmission of antibiotic resistance genes in bacteria through immigration and export/import of foodstuff. The significance of surveillance to define appropriate use of antibiotics in the clinic has been included as an important preventive measure.

Global data on blindness.

PubMed Central

Thylefors, B.; Négrel, A. D.; Pararajasegaram, R.; Dadzie, K. Y.

1995-01-01

Globally, it is estimated that there are 38 million persons who are blind. Moreover, a further 110 million people have low vision and are at great risk of becoming blind. The main causes of blindness and low vision are cataract, trachoma, glaucoma, onchocerciasis, and xerophthalmia; however, insufficient data on blindness from causes such as diabetic retinopathy and age-related macular degeneration preclude specific estimations of their global prevalence. The age-specific prevalences of the major causes of blindness that are related to age indicate that the trend will be for an increase in such blindness over the decades to come, unless energetic efforts are made to tackle these problems. More data collected through standardized methodologies, using internationally accepted (ICD-10) definitions, are needed. Data on the incidence of blindness due to common causes would be useful for calculating future trends more precisely. PMID:7704921

The lead/acid battery — a key technology for global energy management

NASA Astrophysics Data System (ADS)

Rand, D. A. J.

As the nations of the world continue to develop, their industrialization and growing populations will require increasing amounts of energy. Yet, global energy consumption, even at present levels, is already giving rise to concerns over both the security of future supplies and the attendant problems of environmental degradation. Thus, a major objective for the energy industry — in all its sectors — is to develop procedures so that the burgeoning demand for energy can be tolerated without exhaustion of the planet's resources, and without further deterioration of the global ecosystem. A step in the right direction is to place lead/acid batteries — serviceable, efficient and clean technology — at the cutting edge of energy strategies, regardless of the relatively low price of such traditional fuels as coal, mineral oil and natural gas.

Contribution of soil respiration to the global carbon equation.

PubMed

Xu, Ming; Shang, Hua

2016-09-20

Soil respiration (Rs) is the second largest carbon flux next to GPP between the terrestrial ecosystem (the largest organic carbon pool) and the atmosphere at a global scale. Given their critical role in the global carbon cycle, Rs measurement and modeling issues have been well reviewed in previous studies. In this paper, we briefly review advances in soil organic carbon (SOC) decomposition processes and the factors affecting Rs. We examine the spatial and temporal distribution of Rs measurements available in the literature and found that most of the measurements were conducted in North America, Europe, and East Asia, with major gaps in Africa, East Europe, North Asia, Southeast Asia, and Australia, especially in dry ecosystems. We discuss the potential problems of measuring Rs on slope soils and propose using obliquely-cut soil collars to solve the existing problems. We synthesize previous estimates of global Rs flux and find that the estimates ranged from 50 PgC/yr to 98 PgC/yr and the error associated with each estimation was also high (4 PgC/yr to 33.2 PgC/yr). Using a newly integrated database of Rs measurements and the MODIS vegetation map, we estimate that the global annual Rs flux is 94.3 PgC/yr with an estimation error of 17.9 PgC/yr at a 95% confidence level. The uneven distribution of Rs measurements limits our ability to improve the accuracy of estimation. Based on the global estimation of Rs flux, we found that Rs is highly correlated with GPP and NPP at the biome level, highlighting the role of Rs in global carbon budgets. Copyright © 2016. Published by Elsevier GmbH.

Optimizing Global Coronal Magnetic Field Models Using Image-Based Constraints

NASA Technical Reports Server (NTRS)

Jones-Mecholsky, Shaela I.; Davila, Joseph M.; Uritskiy, Vadim

2016-01-01

The coronal magnetic field directly or indirectly affects a majority of the phenomena studied in the heliosphere. It provides energy for coronal heating, controls the release of coronal mass ejections, and drives heliospheric and magnetospheric activity, yet the coronal magnetic field itself has proven difficult to measure. This difficulty has prompted a decades-long effort to develop accurate, timely, models of the field, an effort that continues today. We have developed a method for improving global coronal magnetic field models by incorporating the type of morphological constraints that could be derived from coronal images. Here we report promising initial tests of this approach on two theoretical problems, and discuss opportunities for application.

Fraud at the Global Fund? A viewpoint.

PubMed

Brown, Jonathan C; Griekspoor, Wilfred

2013-01-01

The Global Fund to Fight AIDS, Tuberculosis and Malaria has contributed to remarkable health improvements in the three diseases since its creation in 2002. However, media reports about "astonishing losses" and fraud in Fund programs in 2011 caused several donors to suspend funding. The Fund's annual round of new financing was canceled, and a substantial reform program is being implemented. Two former senior managers of the Fund contend that fraud was never a major problem; rather than imposing harsh new controls on recipient countries that might impede health outcomes, the Fund should maintain the core elements of its innovative model and make selective rather than sweeping changes in its operations. Copyright © 2012 John Wiley & Sons, Ltd.

OPTIMIZING GLOBAL CORONAL MAGNETIC FIELD MODELS USING IMAGE-BASED CONSTRAINTS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jones, Shaela I.; Davila, Joseph M.; Uritsky, Vadim, E-mail: shaela.i.jonesmecholsky@nasa.gov

The coronal magnetic field directly or indirectly affects a majority of the phenomena studied in the heliosphere. It provides energy for coronal heating, controls the release of coronal mass ejections, and drives heliospheric and magnetospheric activity, yet the coronal magnetic field itself has proven difficult to measure. This difficulty has prompted a decades-long effort to develop accurate, timely, models of the field—an effort that continues today. We have developed a method for improving global coronal magnetic field models by incorporating the type of morphological constraints that could be derived from coronal images. Here we report promising initial tests of thismore » approach on two theoretical problems, and discuss opportunities for application.« less

Global statistics on addictive behaviours: 2014 status report.

PubMed

Gowing, Linda R; Ali, Robert L; Allsop, Steve; Marsden, John; Turf, Elizabeth E; West, Robert; Witton, John

2015-06-01

Addictive behaviours are among the greatest scourges on humankind. It is important to estimate the extent of the problem globally and in different geographical regions. Such estimates are available, but there is a need to collate and evaluate these to arrive at the best available synthetic figures. Addiction has commissioned this paper as the first of a series attempting to do this. Online sources of global, regional and national information on prevalence and major harms relating to alcohol use, tobacco use, unsanctioned psychoactive drug use and gambling were identified through expert review and assessed. The primary data sources located were the websites of the World Health Organization (WHO), the United Nations Office on Drugs and Crime (UNODC) and the Alberta Gambling Research Institute. Summary statistics were compared with recent publications on the global epidemiology of addictive behaviours. An estimated 4.9% of the world's adult population (240 million people) suffer from alcohol use disorder (7.8% of men and 1.5% of women), with alcohol causing an estimated 257 disability-adjusted life years lost per 100 000 population. An estimated 22.5% of adults in the world (1 billion people) smoke tobacco products (32.0% of men and 7.0% of women). It is estimated that 11% of deaths in males and 6% of deaths in females each year are due to tobacco. Of 'unsanctioned psychoactive drugs', cannabis is the most prevalent at 3.5% globally, with each of the others at < 1%; 0.3% of the world's adult population (15 million people) inject drugs. Use of unsanctioned psychoactive drugs accounts for an estimated 83 disability-adjusted life years lost per 100 000 population. Global estimates of problem gambling are not possible, but in countries where it has been assessed the prevalence is estimated at 1.5%. Tobacco and alcohol use are by far the most prevalent addictive behaviours and cause the large majority of the harm. However, the quality of data on prevalence and addiction-related harms is mostly low, and comparisons between countries and regions must be viewed with caution. There is an urgent need to review the quality of data on which global estimates are made and coordinate efforts to arrive at a more consistent approach. © 2015 Reviews.

Reproductive rights and responsibilities.

PubMed

Oliviera, R D

1994-01-01

Rosiska Darcy Oliviera, Executive Secretary of the Coalition of Brazilian Women from Non-governmental Organizations for Population and Environment, stresses the need to view population control as a political problem rather than just a technical problem of demographic organization. At present, science, technology, and capital separate the work in much the same way that the master slave relationship of colonialist times did. The vast majority of the excluded are from developing countries in the South and, from a market perspective, these outcasts serve no purpose to global processes. Relegated to the margins of society, outcasts are often forced to turn to illegal activities such as drug trafficking and prostitution to survive, and these behaviors are used to bolster racist ideology. Improving the quality of life for all men and women requires a global alliance to overcome this social apartheid. If women are to exercise their reproductive rights, women's health programs must extend their focus beyond contraception to include education that empowers women to make real choices and a material base that permits access to a spectrum of safe methods.

[Ground-clearing fires in the amazon and respiratory disease].

PubMed

Gonçalves, Karen dos Santos; de Castro, Hermano Albuquerque; Hacon, Sandra de Souza

2012-06-01

The intentional burning of forest biomass commonly known as "ground-clearing fires" is an age-old and widespread practice in the country and is seen as a major contributor to global emissions of greenhouse gases. However, global awareness of their potential impact is relatively recent. The occurrence of large ground-clearing fires in the Brazilian and international scenarios drew attention to the problem, but the measures taken to prevent and/or control the fires are still insufficient. In the Amazon region, with distinct geographical and environmental features from the rest of the country, with its historic process of land occupation, every year the ground-clearing fires expose larger portions of the population making them vulnerable to its effects. In this context, this non-systematic review presents the papers written over the past five years about the fires in the Brazilian Amazon and respiratory illness. The main objective is to provide information for managers and leaders on environmental issues about the problems related to biomass burning in the Amazon region.

Suicide and deliberate self-harm in Afghanistan.

PubMed

Paiman, Mohammad Akbar; Khan, Murad Moosa

2017-04-01

Suicide and deliberate self-harm (DSH) are major public health problems globally. There is limited information on suicide and DSH from Afghanistan. To review available literature on suicide and DSH in Afghanistan. Using online resources and literature on suicidal behavior (suicide, DSH and suicidal ideation) was searched. There were only seven published studies identified on suicidal behavior in Afghanistan. Six of these have been published since 2003 and majority has focused on suicidal behavior in women. Both DSH and suicide are underreported and understudied subjects in Afghanistan. There is need for more research in this area. Copyright © 2017 Elsevier B.V. All rights reserved.

Heat Shock Proteins in Association with Heat Tolerance in Grasses

PubMed Central

Xu, Yan; Zhan, Chenyang; Huang, Bingru

2011-01-01

The grass family Poaceae includes annual species cultivated as major grain crops and perennial species cultivated as forage or turf grasses. Heat stress is a primary factor limiting growth and productivity of cool-season grass species and is becoming a more significant problem in the context of global warming. Plants have developed various mechanisms in heat-stress adaptation, including changes in protein metabolism such as the induction of heat shock proteins (HSPs). This paper summarizes the structure and function of major HSPs, recent research progress on the association of HSPs with grass tolerance to heat stress, and incorporation of HSPs in heat-tolerant grass breeding. PMID:22084689

"Nudges" to Prevent Behavioral Risk Factors Associated With Major Depressive Disorder.

PubMed

Woodend, Ashleigh; Schölmerich, Vera; Denktaş, Semiha

2015-11-01

Major depressive disorder-colloquially called "depression"-is a primary global cause of disability. Current preventive interventions, such as problem-solving therapy, are effective but also expensive. "Nudges" are easy and cheap interventions for altering behavior. We have explored how nudging can reduce three behavioral risk factors of depression: low levels of physical activity, inappropriate coping mechanisms, and inadequate maintenance of social ties. These nudges use cognitive biases associated with these behavioral risks, such as valuing the present more than the future, following the herd or the norm, making different choices in light of equivalent conditions, and deciding on the basis of salience or attachment to status quo.

Historical evolution of ideas on eclampsia/preeclampsia: A proposed optimistic view of preeclampsia.

PubMed

Robillard, Pierre-Yves; Dekker, Gustaaf; Chaouat, Gérard; Scioscia, Marco; Iacobelli, Silvia; Hulsey, Thomas C

2017-09-01

Eclampsia (together with epilepsy) being the first disease ever written down since the beginning of writings in mankind 5000 years ago, we will make a brief presentation of the different major steps in comprehension of Pre-eclampsia. 1) 1840. Rayer, description of proteinuria in eclampsia, 2) 1897 Vaquez, discovery of gestational hypertension in eclamptic women, 3) In the 1970's, description of the "double" trophoblastic invasion existing only in humans (Brosens & Pijnenborg,), 4) between the 1970's and the 1990's, description of preeclampsia being a couple disease. The "paternity problem" (and therefore irruption of immunology), 5) at the end of the 1980's, a major step forward: Preeclampsia being a global endothelial cell disease (glomeruloendotheliosis, hepatic or cerebral endotheliosis, HELLP, eclampsia), inflammation (J.Roberts.C Redman, R Taylor), 6) End of the 1990's: Consensus for a distinction between early onset preeclampsia EOP and late onset LOP (34 weeks gestation), EOP being rather a problem of implantation of the trophoblast (and the placenta), LOP being rather a pre-existing maternal problem (obesity, diabetes, coagulopathies etc…). LOP is predominant everywhere on this planet, but enormously predominant in developed countries: 90% of cases. This feature is very different in countries where women have their first child very young (88% of world births), where the fatal EOP (early onset) occurs in more than 30% of cases. 7) What could be the common factor which could explain the maternal global endotheliosis in EOP and LOP? Discussion about the inositol phospho glycans P type. Copyright © 2017. Published by Elsevier B.V.

Strategies for Global Optimization of Temporal Preferences

NASA Technical Reports Server (NTRS)

Morris, Paul; Morris, Robert; Khatib, Lina; Ramakrishnan, Sailesh

2004-01-01

A temporal reasoning problem can often be naturally characterized as a collection of constraints with associated local preferences for times that make up the admissible values for those constraints. Globally preferred solutions to such problems emerge as a result of well-defined operations that compose and order temporal assignments. The overall objective of this work is a characterization of different notions of global preference, and to identify tractable sub-classes of temporal reasoning problems incorporating these notions. This paper extends previous results by refining the class of useful notions of global temporal preference that are associated with problems that admit of tractable solution techniques. This paper also answers the hitherto open question of whether problems that seek solutions that are globally preferred from a Utilitarian criterion for global preference can be found tractably.

Teaching Global Issues Through Mathematics. Development Education Paper No. 20.

ERIC Educational Resources Information Center

Schwartz, Richard H.

The document shows how teachers can use mathematics problems to teach fourth, fifth, and sixth grade students about critical global issues. The problems are arranged according to development topics. For each problem, the solution, reference source, and mathematical skills to be strengthened are given; global issues related to each problem are also…

The global burden of oral diseases and risks to oral health.

PubMed Central

Petersen, Poul Erik; Bourgeois, Denis; Ogawa, Hiroshi; Estupinan-Day, Saskia; Ndiaye, Charlotte

2005-01-01

This paper outlines the burden of oral diseases worldwide and describes the influence of major sociobehavioural risk factors in oral health. Despite great improvements in the oral health of populations in several countries, global problems still persist. The burden of oral disease is particularly high for the disadvantaged and poor population groups in both developing and developed countries. Oral diseases such as dental caries, periodontal disease, tooth loss, oral mucosal lesions and oropharyngeal cancers, human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS)-related oral disease and orodental trauma are major public health problems worldwide and poor oral health has a profound effect on general health and quality of life. The diversity in oral disease patterns and development trends across countries and regions reflects distinct risk profiles and the establishment of preventive oral health care programmes. The important role of sociobehavioural and environmental factors in oral health and disease has been shown in a large number of socioepidemiological surveys. In addition to poor living conditions, the major risk factors relate to unhealthy lifestyles (i.e. poor diet, nutrition and oral hygiene and use of tobacco and alcohol), and limited availability and accessibility of oral health services. Several oral diseases are linked to noncommunicable chronic diseases primarily because of common risk factors. Moreover, general diseases often have oral manifestations (e.g. diabetes or HIV/AIDS). Worldwide strengthening of public health programmes through the implementation of effective measures for the prevention of oral disease and promotion of oral health is urgently needed. The challenges of improving oral health are particularly great in developing countries. PMID:16211157

Global energy, sustainability, and the conventional development paradigm

DOE Office of Scientific and Technical Information (OSTI.GOV)

Raskin, P.D.; Margolis, R.M.

1998-05-01

The conventional development paradigm assumes that the values, consumption patterns, and dynamics of the western industrial system will be progressively played out on a global scale. In this inquiry, the authors explore the implications of the conventional paradigm for the evolution of global energy patterns, and the compatibility with notions of sustainability. They present a global long-range conventional development scenario to the year 2050, and identify major environmental, resource, and social pressures and uncertainties. These include the economic and geopolitical consequences of fossil fuel depletion, the environmental and security implications of increased nuclear generation, the risk of significant climatic change,more » and the threats to social cohesion of distributional inequities. Such potential problems could negate the basic scenario assumption of steady economic and social development. By clarifying the stress points in a conventional picture of energy development, the scenario provides a useful point of departure for examining alternative long-range scenarios for sustainable energy development.« less

The changing context of Western European healthcare systems: convergence versus divergence in nursing problematics.

PubMed

Spitzer, Ada; Camus, Didier; Desaulles, Cécile; Kuhne, Nicolas

2006-10-01

Many countries reorganizing their health services are drawn toward similar reform programs and tend to experience what seem to be similar problems relating to implementation outcomes. One such problem is the major crisis within the nursing profession relating to the labor market, working conditions and level of autonomy. This research examines the thesis that the profile of nursing problems is global (the 'convergence' thesis) by comparing the changing hospital contexts nursing has been confronting in 20 Western European countries between 1990 and 2001. The analysis indicates that in spite of growing convergence, the divergence in patient care processes, workforce composition and resources allocated for care is still rather remarkable and that similarity or divergence between countries changes over time. This contextual variability highlights why problems such as the crisis of the nursing profession must be analysed from a divergent rather than a convergent perspective.

The global burden of cataract.

PubMed

Rao, Gullapalli N; Khanna, Rohit; Payal, Abhishek

2011-01-01

To review the previous year's literature related to prevalence of blindness in general, blindness due to cataract, cataract surgical coverage (CSC) and cataract surgical rates (CSRs). Cataracts are the major cause of blindness and visual impairment in developing countries and contributes to more than 90% of the total disability adjusted life years. This review shows that coverage continues to be a problem in many countries, especially for the female population, those residing in rural areas and those who are illiterate. Although CSR is an indicator of the availability and acceptability of services, for measuring the impact of the program, we should look at combining CSR with CSC. This strategy would also enable us achieve our goal of eliminating avoidable blindness due to cataracts by the year 2020. Cataracts still continue- to be a major cause of blindness globally and with the rapidly aging population, it is a challenge to tackle. We need to plan a comprehensive strategy addressing issues related to availability, affordability, accessibility and acceptability of eye-care services.

Seawater/Saline Agriculture for Energy, Warming, Water, Rainfall, Land, Food and Minerals

NASA Technical Reports Server (NTRS)

Bushnell, Dennis

2006-01-01

The combination of the incipient demise of cheap oil and increasing evidence of Global Warming due to anthropogenic fossil carbon release has reinvigorated the need for and efforts on Renewable energy sources, especially for transportation applications. Biomass/Bio-diesel appears to have many benefits compared to Hydrogen, the only other major renewable transportation fuel candidate. Biomass Production is currently limited by available arable land and fresh water. Halophyte Plants and seawater irrigation proffer a wholly new biomass production mantra using wastelands and very plentiful seawater. Such an approach addresses many-to-most of the major emerging Societal Problems including Land, Water, Food, Warming and Energy. For many reasons, including seawater agriculture, portions of the Sahara appear to be viable candidates for future Biomass Production. The apparent nonlinearity between vegetation cover and atmospheric conditions over North Africa necessitates serious coupled boundary layer Meteorology and Global Circulation Modeling to ensure that this form of Terra Forming is Favorable and to avoid adverse Unintended Consequences.

Who pays for cooperation in global health? A comparative analysis of WHO, the World Bank, the Global Fund to Fight HIV/AIDS, Tuberculosis and Malaria, and Gavi, the Vaccine Alliance.

PubMed

Clinton, Chelsea; Sridhar, Devi

2017-07-15

In this report we assess who pays for cooperation in global health through an analysis of the financial flows of WHO, the World Bank, the Global Fund to Fight HIV/AIDS, TB and Malaria, and Gavi, the Vaccine Alliance. The past few decades have seen the consolidation of influence in the disproportionate roles the USA, UK, and the Bill & Melinda Gates Foundation have had in financing three of these four institutions. Current financing flows in all four case study institutions allow donors to finance and deliver assistance in ways that they can more closely control and monitor at every stage. We highlight three major trends in global health governance more broadly that relate to this development: towards more discretionary funding and away from core or longer-term funding; towards defined multi-stakeholder governance and away from traditional government-centred representation and decision-making; and towards narrower mandates or problem-focused vertical initiatives and away from broader systemic goals. Copyright © 2017 Elsevier Ltd. All rights reserved.

Global magnetohydrodynamic simulations on multiple GPUs

NASA Astrophysics Data System (ADS)

Wong, Un-Hong; Wong, Hon-Cheng; Ma, Yonghui

2014-01-01

Global magnetohydrodynamic (MHD) models play the major role in investigating the solar wind-magnetosphere interaction. However, the huge computation requirement in global MHD simulations is also the main problem that needs to be solved. With the recent development of modern graphics processing units (GPUs) and the Compute Unified Device Architecture (CUDA), it is possible to perform global MHD simulations in a more efficient manner. In this paper, we present a global magnetohydrodynamic (MHD) simulator on multiple GPUs using CUDA 4.0 with GPUDirect 2.0. Our implementation is based on the modified leapfrog scheme, which is a combination of the leapfrog scheme and the two-step Lax-Wendroff scheme. GPUDirect 2.0 is used in our implementation to drive multiple GPUs. All data transferring and kernel processing are managed with CUDA 4.0 API instead of using MPI or OpenMP. Performance measurements are made on a multi-GPU system with eight NVIDIA Tesla M2050 (Fermi architecture) graphics cards. These measurements show that our multi-GPU implementation achieves a peak performance of 97.36 GFLOPS in double precision.

E-Waste and Harm to Vulnerable Populations: A Growing Global Problem

PubMed Central

Heacock, Michelle; Kelly, Carol Bain; Asante, Kwadwo Ansong; Birnbaum, Linda S.; Bergman, Åke Lennart; Bruné, Marie-Noel; Buka, Irena; Carpenter, David O.; Chen, Aimin; Huo, Xia; Kamel, Mostafa; Landrigan, Philip J.; Magalini, Federico; Diaz-Barriga, Fernando; Neira, Maria; Omar, Magdy; Pascale, Antonio; Ruchirawat, Mathuros; Sly, Leith; Sly, Peter D.; Van den Berg, Martin; Suk, William A.

2015-01-01

Background: Electronic waste (e-waste) is produced in staggering quantities, estimated globally to be 41.8 million tonnes in 2014. Informal e-waste recycling is a source of much-needed income in many low- to middle-income countries. However, its handling and disposal in underdeveloped countries is often unsafe and leads to contaminated environments. Rudimentary and uncontrolled processing methods often result in substantial harmful chemical exposures among vulnerable populations, including women and children. E-waste hazards have not yet received the attention they deserve in research and public health agendas. Objectives: We provide an overview of the scale and health risks. We review international efforts concerned with environmental hazards, especially affecting children, as a preface to presenting next steps in addressing health issues stemming from the global e-waste problem. Discussion: The e-waste problem has been building for decades. Increased observation of adverse health effects from e-waste sites calls for protecting human health and the environment from e-waste contamination. Even if e-waste exposure intervention and prevention efforts are implemented, legacy contamination will remain, necessitating increased awareness of e-waste as a major environmental health threat. Conclusion: Global, national, and local levels efforts must aim to create safe recycling operations that consider broad security issues for people who rely on e-waste processing for survival. Paramount to these efforts is reducing pregnant women and children’s e-waste exposures to mitigate harmful health effects. With human environmental health in mind, novel dismantling methods and remediation technologies and intervention practices are needed to protect communities. Citation: Heacock M, Kelly CB, Asante KA, Birnbaum LS, Bergman AL, Bruné MN, Buka I, Carpenter DO, Chen A, Huo X, Kamel M, Landrigan PJ, Magalini F, Diaz-Barriga F, Neira M, Omar M, Pascale A, Ruchirawat M, Sly L, Sly PD, Van den Berg M, Suk WA. 2016. E-waste and harm to vulnerable populations: a growing global problem. Environ Health Perspect 124:550–555; http://dx.doi.org/10.1289/ehp.1509699 PMID:26418733

Global assessment of nitrogen fertilizer: the SCOPE/IGBP nitrogen fertilizer rapid assessment project.

PubMed

Mosier, Arvin R; Syers, J Keith; Freney, John R

2005-12-01

Nitrogen (N) availability is a key role in food and fiber production. Providing plant-available N through synthetic fertilizer in the 20th and early 21st century has been a major contributor to the increased production required to feed and clothe the growing human population. To continue to meet the global demands and to minimize environmental problems, significant improvements are needed in the efficiency with which fertilizer N is utilized within production systems. There are still major uncertainties regarding the fate of fertilizer N added to agricultural soils and the potential for reducing losses to the environment. Enhancing the technical and economic efficiency of fertilizer N is seen to promote a favorable situation for both agricultural production and the environment, and this has provided much of the impetus for a new N fertilizer project. To address this important issue, a rapid assessment project on N fertilizer (NFRAP) was conducted by SCOPE (the Scientific Committee on Problems of the Environment) during late 2003 and early 2004. This was the first formal project of the International Nitrogen Initiative (INI). As part of this assessment, a successful international workshop was held in Kampala, Uganda on 12 -16 January, 2004. This workshop brought together scientists from around the world to assess the fate of synthetic fertilizer N in the context of overall N inputs to agricultural systems, with a view to enhancing the efficiency of N use and reducing negative impacts on the environment. Regionalization of the assessment highlighted the problems of too little N for crop production to meet the nutrient requirements of sub-Saharan Africa and the oversupply of N in the major rice-growing areas of China. The results of the assessment are presented in a book (SCOPE 65) which is now available to provide a basis for further discussions on N fertilizer.

Global assessment of nitrogen fertilizer: the SCOPE/IGBP nitrogen fertilizer rapid assessment project.

PubMed

Mosier, Arvin R; Syers, J Keith; Freney, John R

2005-09-01

Nitrogen (N) availability is a key role in food and fiber production. Providing plant-available N through synthetic fertilizer in the 20th and early 21st century has been a major contributor to the increased production required to feed and clothe the growing human population. To continue to meet the global demands and to minimize environmental problems, significant improvements are needed in the efficiency with which fertilizer N is utilized within production systems. There are still major uncertainties regarding the fate of fertilizer N added to agricultural soils and the potential for reducing losses to the environment. Enhancing the technical and economic efficiency of fertilizer N is seen to promote a favorable situation for both agricultural production and the environment, and this has provided much of the impetus for a new N fertilizer project. To address this important issue, a rapid assessment project on N fertilizer (NFRAP) was conducted by SCOPE (the Scientific Committee on Problems of the Environment) during late 2003 and early 2004. This was the first formal project of the International Nitrogen Initiative (INI). As part of this assessment, a successful international workshop was held in Kampala, Uganda on 12 -16 January, 2004. This workshop brought together scientists from around the world to assess the fate of synthetic fertilizer N in the context of overall N inputs to agricultural systems, with a view to enhancing the efficiency of N use and reducing negative impacts on the environment. Regionalization of the assessment highlighted the problems of too little N for crop production to meet the nutrient requirements of sub-Saharan Africa and the oversupply of N in the major rice-growing areas of China. The results of the assessment are presented in a book (SCOPE 65) which is now available to provide a basis for further discussions on N fertilizer.

Drivers for the emergence and re-emergence of vector-borne protozoal and bacterial diseases.

PubMed

Harrus, S; Baneth, G

2005-10-01

In recent years, vector-borne parasitic and bacterial diseases have emerged or re-emerged in many geographical regions causing global health and economic problems that involve humans, livestock, companion animals and wild life. The ecology and epidemiology of vector-borne diseases are affected by the interrelations between three major factors comprising the pathogen, the host (human, animal or vector) and the environment. Important drivers for the emergence and spread of vector-borne parasites include habitat changes, alterations in water storage and irrigation habits, atmospheric and climate changes, immunosuppression by HIV, pollution, development of insecticide and drug resistance, globalization and the significant increase in international trade, tourism and travel. War and civil unrest, and governmental or global management failure are also major contributors to the spread of infectious diseases. The improvement of epidemic understanding and planning together with the development of new diagnostic molecular techniques in the last few decades have allowed researchers to better diagnose and trace pathogens, their origin and routes of infection, and to develop preventive public health and intervention programs. Health care workers, physicians, veterinarians and biosecurity officers should play a key role in future prevention of vector-borne diseases. A coordinated global approach for the prevention of vector-borne diseases should be implemented by international organizations and governmental agencies in collaboration with research institutions.

Regulation of water resources for sustaining global future socioeconomic development

NASA Astrophysics Data System (ADS)

Chen, J.; SHI, H.; Sivakumar, B.

2016-12-01

With population projections indicating continued growth during this century, socio-economic problems (e.g., water, food, and energy shortages) will be most likely to occur, especially if proper planning, development, and management strategies are not adopted. In the present study, firstly, we explore the vital role of dams in promoting economic growth through analyzing the relationship between dams and Gross Domestic Product (GDP) at both global and national scales. Secondly, we analyze the current situation of global water scarcity based on the data representing water resources availability, dam development, and the level of economic development. Third, with comprehensive consideration of population growth as the major driving force, water resources availability as the basic supporting factor, and topography as the important constraint, this study addresses the question of dam development in the future and predicts the locations of future dams around the world.

Synergies and trade-offs between food security and biodiversity conservation

NASA Astrophysics Data System (ADS)

Molotoks, Amy

2016-04-01

Human land use activities have transformed a large proportion of the world's land surface and in particular, the expansion of agriculture has been a major driver in global land use change. The conversion of natural ecosystems to crop and pasture lands has contributed significantly to deforestation and associated biodiversity loss through habitat destruction. This loss has raised concerns about associated loss of ecological functions which directly support over one billion people worldwide. Furthermore, agriculture itself is heavily reliant on a number of ecosystem services which are essential for crop production. It is therefore essential that the global problems of food insecurity and biodiversity loss are not viewed independently as the methods used to address one will necessarily involve choices affecting the other. This poster will examine the relationship between food security provision and biodiversity hotspots by using global spatial datasets of land use and conservation value.

Problems in Assessment of the UV Penetration into Natural Waters from Space-based Measurements

NASA Technical Reports Server (NTRS)

Vasilkov, Alexander P.; Herman, Jay; Krotkov, Nickolay A.; Kahru, Mati; Mitchell, B. Greg; Hsu, Christina; Bhartia, P. K. (Technical Monitor)

2002-01-01

Satellite instruments currently provide global maps of surface UV (ultraviolet) irradiance by combining backscattered radiance data with radiative transfer models. The models are often limited by uncertainties in physical input parameters of the atmosphere and surface. Global mapping of the underwater UV irradiance creates further challenges for the models. The uncertainties in physical input parameters become more serious because of the presence of absorbing and scattering quantities caused by biological processes within the oceans. In this paper we summarize the problems encountered in the assessment of the underwater UV irradiance from space-based measurements, and propose approaches to resolve the problems. We have developed a radiative transfer scheme for computation of the UV irradiance in the atmosphere-ocean system. The scheme makes use of input parameters derived from satellite instruments such as TOMS (Total Ozone Mapping Spectrometer) and SeaWiFS (Sea-viewing Wide Field-of-view Sensor). The major problem in assessment of the surface UV irradiance is to accurately quantify the effects of clouds. Unlike the standard TOMS UV algorithm, we use the cloud fraction products available from SeaWiFS and MODIS (Moderate Resolution Imaging Spectrometer) to calculate instantaneous surface flux at the ocean surface. Daily UV doses can be calculated by assuming a model of constant cloudiness throughout the day. Both SeaWiFS and MODIS provide some estimates of seawater optical properties in the visible. To calculate the underwater UV flux the seawater optical properties must be extrapolated down to shorter wavelengths. Currently, the problem of accurate extrapolation of visible data down to the UV spectral range is not solved completely, and there are few available measurements. The major difficulty is insufficient correlation between photosynthetic and photoprotective pigments of phytoplankton absorbing in the visible and UV respectively. We propose to empirically parameterize seawater absorption in the UV on a basis of available data sets of bio-optical measurements from a variety of ocean waters. Another problem is the lack of reliable data on pure seawater absorption in the UV. Laboratory measurements of the UV absorption of both pure water and pure seawater are required.

Chronic obstructive pulmonary disease: More than meets the eye.

PubMed

Hatipoğlu, Umur

2018-01-01

Chronic obstructive pulmonary disease (COPD) is a major health problem which had not received the attention commensurate with the magnitude of its global burden. This is finally changing with the help of a vibrant community of health-care professionals, public officials, and academic researchers. Advances in characterization of the disease, treatment options, imaging modalities, and better understanding of the comorbidities promise to revolutionize how the disease is managed. COPD should no longer augur despair among physicians and patients.

The truth lies somewhere in the middle: Swinging between globalization and regionalization of medical education in Japan.

PubMed

Saiki, Takuya; Imafuku, Rintaro; Suzuki, Yasuyuki; Ban, Nobutaro

2017-10-01

Japan is well known as a super-aging society, with a low birth rate, and has been ranked as one of the countries having the highest quality of healthcare system. Japan's society is currently approaching a major turning point with regard to societal and healthcare reforms, which are influenced by international trends and regional needs. Development of Japanese healthcare human resources, including medical students, is now expected to ride the wave of globalization, while resolving regional problems in the training and delivery of healthcare. Terms and global trends in medical education, such as outcome-based education, community-based education, reflective learning, international accreditation of medical education, and professionalization of educators are well translated into the Japanese language and embraced positively among the Japanese medical educators. However, these trends occasionally sit uncomfortably with cultural variations that are often a common approach in Japan; notably, "hansei" (introspection) and "kaizen" (change for the better). In the world facing a new era where people are unsettled between globalism and regionalism, Japan's future mission is to steer a balanced route that recognizes both global and regional influences and produce global health professionals educators.

Salutogenesis, globalization, and communication.

PubMed

Petzold, Theodor Dierk; Lehmann, Nadja

2011-12-01

Achieving successful communication in transcultural contexts means integrating emotional communication patterns into a global context. Professional, rational communication is characteristic of the cultural dimension, and emotions are characteristic of the direct, interpersonal dimension of human existence. Humans strive to achieve coherence in all dimensions of their lives; this goal is in the end the most essential aspect of psychophysical self-regulation. A major role in integrating emotional needs and cultural features in global coherence is played by the attractor 'global affinity'. The transitions from emotional coherence to cultural coherence, and likewise from cultural coherence to global coherence, can cause considerable insecurity as well as psychological problems, which previously went by the name 'adjustment disorders'. However, instead of pathologizing these processes, we should understand them in a salutogenic sense as challenges important for both individual and collective development. The development of more coherence is regulated by the neuropsychological approach and avoidance system. This system can be consciously fostered by directing our attention to the commonalities of all human beings. Such a global salutogenic orientation furthers both communication and creativity in teamwork. This article introduces a consequent salutogenic and evolutionary systemic view of transcultural communication and demonstrates its effectiveness in a number of case examples.

Citizenship and Science Education.

ERIC Educational Resources Information Center

Bybee, Rodger W.

1982-01-01

Discusses purposes and policies of science education, including present growth trends and the resulting problems of human ecological scarcity, global nature of these problems, and the need for a global response to alter current trends. Emphasizes the role of science/technology in the amelioration of global problems. (Author/JN)

Global responses for recycling waste CRTs in e-waste.

PubMed

Singh, Narendra; Li, Jinhui; Zeng, Xianlai

2016-11-01

The management of used cathode ray tube (CRT) devices is a major problem worldwide due to rapid uptake of the technology and early obsolescence of CRT devices, which is considered an environment hazard if disposed improperly. Previously, their production has grown in step with computer and television demand but later on with rapid technological innovation; TVs and computer screens has been replaced by new products such as Liquid Crystal Displays (LCDs) and Plasma Display Panel (PDPs). This change creates a large volume of waste stream of obsolete CRTs waste in developed countries and developing countries will be becoming major CRTs waste producers in the upcoming years. We studied that there is also high level of trans-boundary movement of these devices as second-hand electronic equipment into developing countries in an attempt to bridge the 'digital divide'. Moreover, the current global production of e-waste is estimated to be '41million tonnes per year' where a major part of the e-waste stream consists of CRT devices. This review article provides a concise overview of world's current CRTs waste scenario, namely magnitude of the demand and processing, current disposal and recycling operations. Copyright © 2016 Elsevier Ltd. All rights reserved.

The Teaching of Global Environmental Problems According to the Constructivist Approach: As a Focal Point of the Problem and the Availability of Concept Cartoons

ERIC Educational Resources Information Center

Oluk, Sami; Ozalp, Isilay

2007-01-01

In this study, with selecting the focusing point of the problem as the availability of cartoons, the teaching of global environmental problems according to the constructivist theory is investigated on the 7th graders in rural areas. This study is restricted with the global warming (G), ozone depletion (O) and the acid rain (A) problems. In the…

Poverty, health & intellectual property rights with special reference to India.

PubMed

Satyanarayana, K; Srivastava, S

2007-10-01

This paper examines the nexus between poverty and global health with specific focus on IPR protection and attempts to highlight the current global endeavours to overcome barriers to access to medicines for diseases of the poor. The number of very poor people in the world has increased by 10.4 per cent between 1987 and 2001 to 2735 million. India is now home to the largest number of millionaires in the developing countries. But over 800 million Indians who still survive on Rs 20.0 (US$0.5) a day, and rural poverty is on the rise. The link between poverty and health is well established with the underprivileged are more vulnerable to major health risks due to poor nutrition, inadequate access to clean drinking water, sanitation, exposure to indoor smoke, etc. all of which contribute to the huge and growing burden of disease in the poor countries. The global disease burden is not just huge but growing: over 10 million children die of preventable conditions including vaccine-preventable diseases, about 14 million are killed by infectious diseases every year, 90-95 per cent in poor countries. An estimated third of global population has limited or no access to essential medicines. While the number of poor and unhealthy is growing, Government expenditure on health is dwindling. Many of the diseases of the poor require new medicines and none are forthcoming as there is little R&D for these infections. There are several barriers to access to existing and the newly discovered drugs. One major reason is the general lack of interest by the pharma industry to discover new medicines for diseases of the poor due to very limited market in developing countries. In addition, global intellectual property rights (IPR) protection regimes like the Trade Related Intellectual Property Rights (TRIPS) are considered a major obstacle for the poor access to medicines. There have been some global initiatives on the need to improve affordability and accessibility of medicines. Some strategies to promote R&D on diseases of the poor such as Prize Fund Model, the Medical R&D Treaty and steps to invoke flexibilities in TRIPS read with Doha Declaration are discussed. Health of the poor is a global problem that requires global solutions with global participation and commitment.

The (Mis)appropriation of HIV/AIDS advocacy strategies in Global Mental Health: towards a more nuanced approach.

PubMed

Howell, Alison; Mills, China; Rushton, Simon

2017-07-01

Mental health is increasingly finding a place on global health and international development agendas. Advocates for Global Mental Health (GMH), and international organizations such as the World Health Organization (WHO) and the World Bank, argue that treatments available in high-income countries should also be made available in low- and middle-income countries. Such arguments are often made by comparing mental health to infectious diseases, including the relative disease and economic burdens they impose, and pointing to the applicability of the right to access treatment for mental health, not only infectious diseases. HIV/AIDS advocacy in particular has been held up by GMH advocates as offering an appropriate strategy for generating global commitment. There is a need to assess how health issues are framed not only in relation to social goods outside of health (such as human rights, security or development), but also in relation to other health or disease models, and how health policy and practice is shaped as a result. The article debates the merits and consequences of likening mental health to HIV/AIDS, and identifies four major problems with the model for GMH advocacy being developed through these analogies: 1. An inappropriately universalizing global approach to context-specific problems; 2. A conception of human rights that focuses on the right to access treatment at the expense of the right to refuse it; 3. A tendency to treat poverty as a psychiatric issue, rather than recognizing that mental distress can be the result of poverty and other forms of inequality; 4. The prioritization of destigmatization of disease over social justice models. There are significant problems with the wholesale adoption of an (often simplified) version of HIV/AIDS advocacy as a model for GMH. Yet critical engagement with the important and nuanced differences between HIV/AIDS and mental health may nevertheless point to some possibilities for productive engagement and cross-fertilisation between advocates, activists and scholars in both fields.

Deciding on Science: An Analysis of Higher Education Science Student Major Choice Criteria

NASA Astrophysics Data System (ADS)

White, Stephen Wilson

The number of college students choosing to major in science, technology, engineering, and math (STEM) in the United States affects the size and quality of the American workforce (Winters, 2009). The number of graduates in these academic fields has been on the decline in the United States since the 1960s, which, according to Lips and McNeil (2009), has resulted in a diminished ability of the United States to compete in science and engineering on the world stage. The purpose of this research was to learn why students chose a STEM major and determine what decision criteria influenced this decision. According to Ajzen's (1991) theory of planned behavior (TPB), the key components of decision-making can be quantified and used as predictors of behavior. In this study the STEM majors' decision criteria were compared between different institution types (two-year, public four-year, and private four-year), and between demographic groups (age and sex). Career, grade, intrinsic, self-efficacy, and self-determination were reported as motivational factors by a majority of science majors participating in this study. Few students reported being influenced by friends and family when deciding to major in science. Science students overwhelmingly attributed the desire to solve meaningful problems as central to their decision to major in science. A majority of students surveyed credited a teacher for influencing their desire to pursue science as a college major. This new information about the motivational construct of the studied group of science majors can be applied to the previously stated problem of not enough STEM majors in the American higher education system to provide workers required to fill the demand of a globally STEM-competitive United States (National Academy of Sciences, National Academy of Engineering, & Institute of Medicine, 2010).

The extent of problematic alcohol and other drug use within selected South African workplaces.

PubMed

Harker Burnhams, Nadine; Dada, Siphokazi; Linda, Betty; Myers, Bronwyn; Parry, Charles

2013-09-30

The use of alcohol and other drugs (AODs) in the workplace has a major impact on the health and productivity of the workforce globally. Yet information on this issue is limited in South Africa (SA). To describe the nature and extent of AOD problems in selected workplace settings in SA. Secondary data analysis was conducted on a large dataset compiled by an Employee Assistance Programme (EAP) service provider in SA. As part of an EAP risk audit, assessments for AOD-related problems were completed for each employee accessing EAP services (n=10 428) between 2005 and 2011. Data on the socio-demographic profiles, AOD use and impact of AOD use on the work performance of employees were analysed. Findings indicate that employed men are more likely to experience alcohol-related problems than women, the latter demonstrating a higher percentage of drug-related problems. The majority of referrals to the EAPs emanate from the public, industrial and financial sectors. AOD-related problems were also found to significantly impact on employee work performance. The study begins to address the knowledge gap on the extent of AOD use in SA workplaces and points to the need for further investigations into the exact nature of AOD use. In addition, the study highlights the need for intervention programmes and policies suited to the workplace.

Polar process and world climate /A brief overview/

NASA Technical Reports Server (NTRS)

Goody, R.

1980-01-01

A review is presented of events relating polar regions to the world climate, the mechanisms of sea ice and polar ice sheets, and of two theories of the Pleistocene Ice Ages. The sea ice which varies over time scales of one or two years and the polar ice sheets with time changes measured in tens or hundreds of thousands of years introduce two distinct time constants into global time changes; the yearly Arctic sea ice variations affect northern Europe and have some effect over the entire Northern Hemisphere; the ice-albedo coupling in the polar ice sheets is involved in major climatic events such as the Pleistocene ice ages. It is concluded that climate problems require a global approach including the atmosphere, the oceans, and the cryosphere.

From unseen to seen: tackling the global burden of uncorrected refractive errors.

PubMed

Durr, Nicholas J; Dave, Shivang R; Lage, Eduardo; Marcos, Susana; Thorn, Frank; Lim, Daryl

2014-07-11

Worldwide, more than one billion people suffer from poor vision because they do not have the eyeglasses they need. Their uncorrected refractive errors are a major cause of global disability and drastically reduce productivity, educational opportunities, and overall quality of life. The problem persists most prevalently in low-resource settings, even though prescription eyeglasses serve as a simple, effective, and largely affordable solution. In this review, we discuss barriers to obtaining, and approaches for providing, refractive eye care. We also highlight emerging technologies that are being developed to increase the accessibility of eye care. Finally, we describe opportunities that exist for engineers to develop new solutions to positively impact the diagnosis and treatment of correctable refractive errors in low-resource settings.

Modeling falling groundwater tables in major cities of the world

NASA Astrophysics Data System (ADS)

Sutanudjaja, E.; Erkens, G.

2015-12-01

Groundwater use and its over-consumption are one of the major drivers in the hydrology of many major cities in the world, particularly in delta regions. Yet, a global assessment to identify cities with declining groundwater table problems has not been done yet. In this study we used the global hydrological model PCR-GLOBWB (10 km resolution, for 1960-2010). Using this model, we globally calculated groundwater recharge and river discharge/surface water levels, as well as global water demand and abstraction from ground- and surface water resources. The output of PCR-GLOBWB model was then used to force a groundwater MODFLOW-based model simulating spatio-temporal groundwater head dynamics, including groundwater head declines in all major cities - mainly in delta regions - due to escalation in abstraction of groundwater to meet increasing water demand. Using these coupled models, we managed to identify a number of critical cities having groundwater table falling rates above 50 cm/year (average in 2000-2010), such as Barcelona, Houston, Los Angeles, Mexico City, New York, Rome and many large cities in China, Libya, India and Pakistan, as well as in Middle East and Central Asia regions. However, our simulation results overestimate the depletion rates in San Jose, Tokyo, Venice, and other cities where groundwater usages have been aggressively managed and replaced by importing surface water from other places. Moreover, our simulation might underestimate the declining groundwater head trends in some familiar cases, such as Bangkok (12 cm/year), Ho Chi Minh City (34 cm/year), and Jakarta (26 cm/year). The underestimation was due to an over-optimistic model assumption in allocating surface water for satisfying urban water needs. In reality, many big cities, although they are located in wet regions and have abundant surface water availability, still strongly rely on groundwater sources due to inadequate facilities to treat and distribute surface water resources.

Modeling falling groundwater tables in major cities of the world

NASA Astrophysics Data System (ADS)

Sutanudjaja, Edwin; Erkens, Gilles

2016-04-01

Groundwater use and its over-consumption are one of the major drivers in the hydrology of many major cities in the world, particularly in delta regions. Yet, a global assessment to identify cities with declining groundwater table problems has not been done yet. In this study we used the global hydrological model PCR-GLOBWB (10 km resolution, for 1960-2010). Using this model, we globally calculated groundwater recharge and river discharge/surface water levels, as well as global water demand and abstraction from ground- and surface water resources. The output of PCR-GLOBWB model was then used to force a groundwater MODFLOW-based model simulating spatio-temporal groundwater head dynamics, including groundwater head declines in all major cities - mainly in delta regions - due to escalation in abstraction of groundwater to meet increasing water demand. Using these coupled models, we managed to identify a number of critical cities having groundwater table falling rates above 50 cm/year (average in 2000-2010), such as Barcelona, Houston, Los Angeles, Mexico City, New York, Rome and many large cities in China, Libya, India and Pakistan, as well as in Middle East and Central Asia regions. However, our simulation results overestimate the depletion rates in San Jose, Tokyo, Venice, and other cities where groundwater usages have been aggressively managed and replaced by importing surface water from other places. Moreover, our simulation might underestimate the declining groundwater head trends in some familiar cases, such as Bangkok (12 cm/year), Ho Chi Minh City (34 cm/year), and Jakarta (26 cm/year). The underestimation was due to an over-optimistic model assumption in allocating surface water for satisfying urban water needs. In reality, many big cities, although they are located in wet regions and have abundant surface water availability, still strongly rely on groundwater sources due to inadequate facilities to treat and distribute surface water resources.

Global initiatives for improving hospital care for children: state of the art and future prospects.

PubMed

Campbell, Harry; Duke, Trevor; Weber, Martin; English, Mike; Carai, Susanne; Tamburlini, Giorgio

2008-04-01

Deficiencies in the quality of health care are major limiting factors to the achievement of the Millennium Development Goals for child and maternal health. Quality of patient care in hospitals is firmly on the agendas of Western countries but has been slower to gain traction in developing countries, despite evidence that there is substantial scope for improvement, that hospitals have a major role in child survival, and that inequities in quality may be as important as inequities in access. There is now substantial global experience of strategies and interventions that improve the quality of care for children in hospitals with limited resources. The World Health Organization has developed a toolkit that contains adaptable instruments, including a framework for quality improvement, evidence-based clinical guidelines in the form of the Pocket Book of Hospital Care for Children, teaching material, assessment, and mortality audit tools. These tools have been field-tested by doctors, nurses, and other child health workers in many developing countries. This collective experience was brought together in a global World Health Organization meeting in Bali in 2007. This article describes how many countries are achieving improvements in quality of pediatric care, despite limited resources and other major obstacles, and how the evidence has progressed in recent years from documenting the nature and scope of the problems to describing the effectiveness of innovative interventions. The challenges remain to bring these and other strategies to scale and to support research into their use, impact, and sustainability in different environments.

Global solvability and asymptotic behavior of a free boundary problem for the one-dimensional viscous radiative and reactive gas

NASA Astrophysics Data System (ADS)

Jiang, Jie; Zheng, Songmu

2012-12-01

In this paper, we study a Neumann and free boundary problem for the one-dimensional viscous radiative and reactive gas. We prove that under rather general assumptions on the heat conductivity κ, for any arbitrary large smooth initial data, the problem admits a unique global classical solution. Our global existence results improve those results by Umehara and Tani ["Global solution to the one-dimensional equations for a self-gravitating viscous radiative and reactive gas," J. Differ. Equations 234(2), 439-463 (2007), 10.1016/j.jde.2006.09.023; Umehara and Tani "Global solvability of the free-boundary problem for one-dimensional motion of a self-gravitating viscous radiative and reactive gas," Proc. Jpn. Acad., Ser. A: Math. Sci. 84(7), 123-128 (2008)], 10.3792/pjaa.84.123 and by Qin, Hu, and Wang ["Global smooth solutions for the compressible viscous and heat-conductive gas," Q. Appl. Math. 69(3), 509-528 (2011)]., 10.1090/S0033-569X-2011-01218-0 Moreover, we analyze the asymptotic behavior of the global solutions to our problem, and we prove that the global solution will converge to an equilibrium as time goes to infinity. This is the result obtained for this problem in the literature for the first time.

Global Climate Change and Society: Scientific, Policy, and Philosophic Themes

NASA Astrophysics Data System (ADS)

Frodeman, R.; Bullock, M. A.

2001-12-01

The summer of 2001 saw the inauguration of the Global Climate Change and Society Program (GCCS), an eight week, NSF-funded experiment in undergraduate pedagogy held at the University of Colorado and the National Center for Atmospheric Research. Acknowledging from the start that climate change is more than a scientific problem, GCCS began with the simultaneous study of basic atmospheric physics, classical and environmental philosophy, and public policy. In addition to lectures and discussions on these subjects, our twelve undergraduates (majoring in the physical sciences, social sciences, and humanities) also participated in internships with scholars and researchers at NCAR, University of Colorado's Center of the American West, and the Colorado School of Mines, on specific issues in atmospheric science, science policy, and ethics and values. This talk will discuss the outcomes of GCCS: specifically, new insights into interdisciplinary pedagogy and the student creation of an extraordinary "deliverable," a group summary assessment of the global climate change debate. The student assessment called for an integrated discussion of both the science of climate change and the human values related to how we inhabit the world. The problems facing society today cannot be addressed through the single-minded adherence to science and technology; instead, society must develop new means of integrating the humanities and science in a meaningful dialogue about our common future.

“Nudges” to Prevent Behavioral Risk Factors Associated With Major Depressive Disorder

PubMed Central

Schölmerich, Vera; Denktaş, Semiha

2015-01-01

Major depressive disorder—colloquially called “depression”—is a primary global cause of disability. Current preventive interventions, such as problem-solving therapy, are effective but also expensive. “Nudges” are easy and cheap interventions for altering behavior. We have explored how nudging can reduce three behavioral risk factors of depression: low levels of physical activity, inappropriate coping mechanisms, and inadequate maintenance of social ties. These nudges use cognitive biases associated with these behavioral risks, such as valuing the present more than the future, following the herd or the norm, making different choices in light of equivalent conditions, and deciding on the basis of salience or attachment to status quo. PMID:26378823

Viral hepatitis A, B, and C: grown-up issues.

PubMed

Sharapov, Umid M; Hu, Dale J

2010-08-01

Viral hepatitis is a major global health problem associated with significant morbidity and mortality. Although there are five major and distinct human hepatitis viruses characterized to date--referred to as hepatitis A, B, C, D, and E, respectively--only hepatitis A, B, and C are epidemiologically and clinically relevant for adolescents in North America. The clinical presentation of acute infection with each of these viruses is similar; thus, diagnosis depends on the use of specific serologic markers and viral nucleic acids. This review provides data on the epidemiology, clinical symptoms, diagnosis, treatment, and prevention of each of these three viral infections, along with points that are important or unique to adolescent patients.

The Emergence of Undergraduate Majors in Global Health: Systematic Review of Programs and Recommendations for Future Directions

PubMed Central

Drain, Paul K.; Mock, Charles; Toole, David; Rosenwald, Anne; Jehn, Megan; Csordas, Thomas; Ferguson, Laura; Waggett, Caryl; Obidoa, Chinekwu; Wasserheit, Judith N.

2017-01-01

Global health education has been expanding rapidly and several universities have created an undergraduate major degree (bachelor's degree) in global heath or global health studies. Because there are currently no national guidelines for undergraduate degrees in global health, each of these programs was developed along individual lines. To guide the development of future global health majors, we conducted a systematic review of undergraduate majors in global health. We identified eight programs and invited program directors or representatives to a symposium at the Consortium of Universities for Global Health 2016 conference to review their existing undergraduate major in global health and to discuss lessons learned and recommendations for other colleges and universities seeking to develop undergraduate degrees in global health. We noted significant diversity among the existing programs in terms of required courses, international field experiences, and thesis research projects. In this review, we describe these global health programs, their student characteristics, as well as the key educational competencies, program requirements, and core global health courses. Based on program reviews and discussions, we identify seven recommendations for the development and expansion of an undergraduate major in global health and discuss issues that have arisen in the curricular development of these programs that warrant further exploration. As the field of global health education continues to expand, following these students after graduation will be essential to ensure that the degree programs in global health both meet student needs and launch students on viable career pathways. PMID:28077739

Extra-Pulmonary Tuberculosis and Its Surgical Treatment.

PubMed

Fry, Donald E

2016-08-01

Tuberculous infection has declined in the United States but remains a major infectious disease with morbidity and death for millions of people. Although the primary therapy is drugs, complications of the disease require surgical interventions. The published literature on tuberculosis was reviewed to provide a current understanding of the medical treatment of the disease and to define those areas where surgical intervention continues to be necessary. Multi-drug therapy for tuberculosis has become the standard and has reduced the complications of the disease necessitating surgical intervention. However, multi-drug resistance and extensively drug-resistant tuberculosis continue to be major problems and require effective initial therapy with surveillance to define resistant infections. The roles of surgery in tuberculosis are in establishing the diagnosis in extra-pulmonary infection and in the management of complications of disseminated disease. Tuberculosis remains an occupational risk for surgeons and surgical personnel. Tuberculosis is still a global problem, mandating recognition and treatment. Surgeons should have an understanding of the diverse presentation and complications of the disease.

Psychiatric Comorbidities in Patients with Deliberate Self-Harm in a Tertiary Care Center.

PubMed

Ghimire, Subash; Devkota, Sagar; Budhathoki, Rasmita; Sapkota, Nidesh; Thakur, Akhilesh

2014-01-01

Deliberate self-harm (DSH) is one of the common psychiatric emergencies in medical practice. It has become a global health problem with rates increasing over time. Very few studies have been conducted on this important health issue in Nepal. We conducted a hospital based study to evaluate the cause, mode and psychiatric comorbidities present in patients of DSH. This cross sectional study was performed on 200 cases of deliberate self-harm in a tertiary referral centre in Eastern Nepal from April 2012 to July 2012 by the data collected from the medical records of these patients. Various sociodemographic data and psychiatric comorbidities prevalent in them were studied. Most of the patients (77%) were below the age of 35. The female-to-male ratio was 1.35:1. 76% of the patients had received formal education. Majority (73.5%) were married. By occupation, 38% were housewives and 25.5% were students. 72.5% of cases had consumed organophosphates/-chlorides. Interpersonal conflict (72%) was the major cause for DSH. Psychiatric disorders according to ICD-10 criteria were found in 37% of cases and premorbid personality problems were found in 20% of cases. The most prevalent psychiatric disorder was adjustment disorder (13.5%) followed by mood disorder (11%). Majority of DSH cases were of younger generation. Psychiatric disorders and comorbid personality problems were commonly seen in DSH patients. This has significance for proper evaluation and management.

Global gradient estimates for divergence-type elliptic problems involving general nonlinear operators

NASA Astrophysics Data System (ADS)

Cho, Yumi

2018-05-01

We study nonlinear elliptic problems with nonstandard growth and ellipticity related to an N-function. We establish global Calderón-Zygmund estimates of the weak solutions in the framework of Orlicz spaces over bounded non-smooth domains. Moreover, we prove a global regularity result for asymptotically regular problems which are getting close to the regular problems considered, when the gradient variable goes to infinity.

The Pentagon’s New Map...to Oblivion: Why the United States Should Declare War on Oil

DTIC Science & Technology

2005-05-17

U.S. Geological Survey reports that the economically recoverable oil from the reserve would account for only 0.3 percent of the global oil inventory .28...policy is the same...we need to fill in the knowledge and the scientific gaps.,,35 Climate change, it seems, is an acceptable risk. Meanwhile, America...for western skiers ), "extended uncontrolled emissions" could lead to major problems, including releasing significant volumes of sea-level impacting

The Effect of Blending HRM Transformational Leadership Style with HRM ICT Expertise Leadership Style on Creating New HRM Strategy That Enable National Companies to Go Global. Evidence from Jordan: Sayegh Group and Hikma Pharmaceutical Corporation

ERIC Educational Resources Information Center

Khudeir, Hamzeh

2016-01-01

There is no single HRM strategy that can cure all HRM problems and complicated issues. Thus, most companies go by the book in this regard; however, the majorities have their own policies and strategies they use to achieve their objectives in general and competitive advantage in particular. One of the strategies used in HRM is blending HRM…

DoD Global Emerging Infections System Annual Report, Fiscal Year 1999

DTIC Science & Technology

1999-01-01

findings provided the impetus to the government of Peru to change national drug policy regarding treatment of malaria in the Peruvian Amazon . As soon as...feasible, a 13 14 Malaria Emerges in the Amazon Basin of Peru (Department of Loreto) 1992-1997 During the last 10-15 years, malaria has emerged as a major...public health problem in the Amazon basin of South America. In Peru the total number of malaria cases reported annually from the Peruvian Amazon

Neurotoxic snakes of the Americas

PubMed Central

Rolan, Terry D.

2015-01-01

Abstract Snake envenomation is a global problem and often a matter of life or death. Emergency treatment is not always readily available or effective. There are numerous neurotoxic snakes in the Americas, chiefly elapids; some crotalids have also evolved neurotoxic venom. The variability of neurotoxins found in snake venom within the same species makes development and choice of proper antivenom a major challenge that has not been completely addressed. This article reviews the epidemiology, clinical effects, and current treatment of neurotoxic snake envenomation in the Americas. PMID:29443174

Chronic obstructive pulmonary disease: More than meets the eye

PubMed Central

Hatipoğlu, Umur

2018-01-01

Chronic obstructive pulmonary disease (COPD) is a major health problem which had not received the attention commensurate with the magnitude of its global burden. This is finally changing with the help of a vibrant community of health-care professionals, public officials, and academic researchers. Advances in characterization of the disease, treatment options, imaging modalities, and better understanding of the comorbidities promise to revolutionize how the disease is managed. COPD should no longer augur despair among physicians and patients. PMID:29387249

Identifying the causes of water crises: A configurational frequency analysis of 22 basins world wide

NASA Astrophysics Data System (ADS)

Srinivasan, V.; Gorelick, S.; Lambin, E.; Rozelle, S.; Thompson, B.

2010-12-01

Freshwater "scarcity" has been identified as being a major problem world-wide, but it is surprisingly hard to assess if water is truly scarce at a global or even regional scale. Most empirical water research remains location specific. Characterizing water problems, transferring lessons across regions, to develop a synthesized global view of water issues remains a challenge. In this study we attempt a systematic understanding of water problems across regions. We compared case studies of basins across different regions of the world using configurational frequency analysis. Because water crises are multi-symptom and multi-causal, a major challenge was to categorize water problems so as to make comparisons across cases meaningful. In this study, we focused strictly on water unsustainability, viz. the inability to sustain current levels of the anthropogenic (drinking water, food, power, livelihood) and natural (aquatic species, wetlands) into the future. For each case, the causes of three outcome variables, groundwater declines, surface water declines and aquatic ecosystem declines, were classified and coded. We conducted a meta-analysis in which clusters of peer-reviewed papers by interdisciplinary teams were considered to ensure that the results were not biased towards factors privileged by any one discipline. Based on our final sample of 22 case study river basins, some clear patterns emerged. The meta-analysis suggests that water resources managers have long overemphasized the factors governing supply of water resources and while insufficient attention has been paid to the factors driving demand. Overall, uncontrolled increase in demand was twice as frequent as declines in availability due to climate change or decreased recharge. Moreover, groundwater and surface water declines showed distinct causal pathways. Uncontrolled increases in demand due to lack of credible enforcement were a key factor driving groundwater declines; while increased upstream abstractions, inadequate infrastructure investments, and pollution were dominant causes of surface water declines.

Developing a transcultural nursing leadership institute in China.

PubMed

Capitulo, Kathleen Leask

2012-09-01

Globalization has been the hallmark of the 21st century. This article focuses on developing the Transcultural Nursing Leadership Institute (TCNLI) in China. This project built a leadership program in Wenzhou, China, empowering and supporting nurses to solve problems in their own practices with evidence-based approaches and local resources using the Dreyfus International Health Foundation's method Problem Solving for Better Health (PSBH).The partnership began when I was a Visiting Professor in Wenzhou, China and established collegial relationships with the Dean of the School of Nursing and the Chief Nursing Officers of the affiliated hospitals. In contrast to previous visiting scholars who went to China to lecture on health issues, I sought to develop a sustainable program and make a lasting contribution to the nursing practice in Wenzhou. The PSBH model was the method for what became the TCNLI. The TCNLI has taught over 200 nursing leaders to develop and implement major projects and connected them to the global nursing community by facilitating joint research, publications, and education. The journeys "across the bridge" from New York to Wenzhou have taken nursing and healthcare leaders from the United States to China and reciprocally welcomed leaders from Wenzhou to the United States for professional experiences. Outcomes of our partnership include more than 200 completed change projects. International partnerships within the global healthcare community provide a vehicle to navigate the complexities of transcultural differences and ultimately a way to bridge the gap and improve global healthcare.

Sustainable water future with global implications: everyone's responsibility.

PubMed

Kuylenstierna, J L; Bjorklund, G; Najlis, P

1997-01-01

The current use and management of freshwater is not sustainable in many countries and regions of the world. If current trends are maintained, about two-thirds of the world's population will face moderate to severe water stress by 2025 compared to one-third at present. This water stress will hamper economic and social development unless action is taken to deal with the emerging problems. The Comprehensive Assessment of the Freshwater Resources of the World, prepared by the UN and the Stockholm Environment Institute, calls for immediate action to prevent further deterioration of freshwater resources. Although most problems related to water quantity and quality require national and regional solutions, only a global commitment can achieve the necessary agreement on principles, as well as financial means to attain sustainability. Due to the central and integrated role played by water in human activities, any measures taken need to incorporate a wide range of social, ecological and economic factors and needs. The Assessment thus addresses the many issues related to freshwater use, such as integrated land and water management at the watershed level, global food security, water supply and sanitation, ecosystem requirements, pollution, strengthening of major groups, and national water resource assessment capabilities and monitoring networks. Governments are urged to work towards a consensus regarding global principles and guidelines for integrated water management, and towards their implementation in local and regional water management situations. The alternative development options available to countries facing water stress, or the risk thereof, needs to be considered in all aspects of development planning.

SOCIAL ANXIETY DISORDER AND MARIJUANA USE PROBLEMS: THE MEDIATING ROLE OF MARIJUANA EFFECT EXPECTANCIES

PubMed Central

Buckner, Julia D.; Schmidt, Norman B.

2009-01-01

Background: Individuals with social anxiety disorder (SAD) appear particularly vulnerable to marijuana-related problems. Yet, mechanisms underlying this association are unclear. Methods: This study examined the role of marijuana effect expectancies in the relation between SAD and marijuana problems among 107 marijuana users (43.0% female), 26.2% of whom met Diagnostic and Statistical Manual for Mental Disorders—Fourth Edition criteria for SAD. Anxiety and mood disorders were determined during clinical interviews using the Anxiety Disorders Interview Schedule—IV-L (ADIS-IV). Results: Analyses (including sex, marijuana use frequency, major depressive disorder, and other anxiety disorders) suggest that SAD was the only disorder significantly associated with past 3-month marijuana problems. Compared to those without SAD, individuals with SAD were more likely to endorse the following marijuana expectancies: cognitive/behavioral impairment and global negative expectancies. Importantly, these expectancies mediated the relations between SAD status and marijuana problems. Conclusions: These data support the contention that SAD is uniquely related to marijuana problems and provide insight into mechanisms underlying this vulnerability. PMID:19373871

A case-based, problem-based learning approach to prepare master of public health candidates for the complexities of global health.

PubMed

Leon, Juan S; Winskell, Kate; McFarland, Deborah A; del Rio, Carlos

2015-03-01

Global health is a dynamic, emerging, and interdisciplinary field. To address current and emerging global health challenges, we need a public health workforce with adaptable and collaborative problem-solving skills. In the 2013-2014 academic year, the Hubert Department of Global Health at the Rollins School of Public Health-Emory University launched an innovative required core course for its first-year Master of Public Health students in the global health track. The course uses a case-based, problem-based learning approach to develop global health competencies. Small teams of students propose solutions to these problems by identifying learning issues and critically analyzing and synthesizing new information. We describe the course structure and logistics used to apply this approach in the context of a large class and share lessons learned.

On the Performance of Linear Decreasing Inertia Weight Particle Swarm Optimization for Global Optimization

PubMed Central

Arasomwan, Martins Akugbe; Adewumi, Aderemi Oluyinka

2013-01-01

Linear decreasing inertia weight (LDIW) strategy was introduced to improve on the performance of the original particle swarm optimization (PSO). However, linear decreasing inertia weight PSO (LDIW-PSO) algorithm is known to have the shortcoming of premature convergence in solving complex (multipeak) optimization problems due to lack of enough momentum for particles to do exploitation as the algorithm approaches its terminal point. Researchers have tried to address this shortcoming by modifying LDIW-PSO or proposing new PSO variants. Some of these variants have been claimed to outperform LDIW-PSO. The major goal of this paper is to experimentally establish the fact that LDIW-PSO is very much efficient if its parameters are properly set. First, an experiment was conducted to acquire a percentage value of the search space limits to compute the particle velocity limits in LDIW-PSO based on commonly used benchmark global optimization problems. Second, using the experimentally obtained values, five well-known benchmark optimization problems were used to show the outstanding performance of LDIW-PSO over some of its competitors which have in the past claimed superiority over it. Two other recent PSO variants with different inertia weight strategies were also compared with LDIW-PSO with the latter outperforming both in the simulation experiments conducted. PMID:24324383

Double-Difference Global Adjoint Tomography

NASA Astrophysics Data System (ADS)

Orsvuran, R.; Bozdag, E.; Lei, W.; Tromp, J.

2017-12-01

The adjoint method allows us to incorporate full waveform simulations in inverse problems. Misfit functions play an important role in extracting the relevant information from seismic waveforms. In this study, our goal is to apply the Double-Difference (DD) methodology proposed by Yuan et al. (2016) to global adjoint tomography. Dense seismic networks, such as USArray, lead to higher-resolution seismic images underneath continents. However, the imbalanced distribution of stations and sources poses challenges in global ray coverage. We adapt double-difference multitaper measurements to global adjoint tomography. We normalize each DD measurement by its number of pairs, and if a measurement has no pair, as may frequently happen for data recorded at oceanic stations, classical multitaper measurements are used. As a result, the differential measurements and pair-wise weighting strategy help balance uneven global kernel coverage. Our initial experiments with minor- and major-arc surface waves show promising results, revealing more pronounced structure near dense networks while reducing the prominence of paths towards cluster of stations. We have started using this new measurement in global adjoint inversions, addressing azimuthal anisotropy in upper mantle. Meanwhile, we are working on combining the double-difference approach with instantaneous phase measurements to emphasize contributions of scattered waves in global inversions and extending it to body waves. We will present our results and discuss challenges and future directions in the context of global tomographic inversions.

Prophenoloxidase system and its role in shrimp immune responses against major pathogens.

PubMed

Amparyup, Piti; Charoensapsri, Walaiporn; Tassanakajon, Anchalee

2013-04-01

The global shrimp industry still faces various serious disease-related problems that are mainly caused by pathogenic bacteria and viruses. Understanding the host defense mechanisms is likely to be beneficial in designing and implementing effective strategies to solve the current and future pathogen-related problems. Melanization, which is performed by phenoloxidase (PO) and controlled by the prophenoloxidase (proPO) activation cascade, plays an important role in the invertebrate immune system in allowing a rapid response to pathogen infection. The activation of the proPO system, by the specific recognition of microorganisms by pattern-recognition proteins (PRPs), triggers a serine proteinase cascade, eventually leading to the cleavage of the inactive proPO to the active PO that functions to produce the melanin and toxic reactive intermediates against invading pathogens. This review highlights the recent discoveries of the critical roles of the proPO system in the shrimp immune responses against major pathogens, and emphasizes the functional characterizations of four major groups of genes and proteins in the proPO cascade in penaeid shrimp, that is the PRPs, serine proteinases, proPO and inhibitors. Copyright © 2012 Elsevier Ltd. All rights reserved.

Indicators to determine winning renewable energy technologies with an application to photovoltaics.

PubMed

Grossmann, Wolf D; Grossmann, Iris; Steininger, Karl

2010-07-01

Several forms of renewable energy compete for supremacy or for an appropriate role in global energy supply. A form of renewable energy can only play an important role in global energy supply if it fulfills several basic requirements. Its capacity must allow supplying a considerable fraction of present and future energy demand, all materials for its production must be readily available, land demand must not be prohibitive, and prices must reach grid parity in the nearer future. Moreover, a renewable energy technology can only be acceptable if it is politically safe. We supply a collection of indicators which allow assessing competing forms of renewable energy and elucidate why surprise is still a major factor in this field, calling for adaptive management. Photovoltaics (PV) are used as an example of a renewable energy source that looks highly promising, possibly supplemented by solar thermal electricity production (ST). We also show why energy use will contribute to land use problems and discuss ways in which the right choice of renewables may be indispensible in solving these problems.

Global Incidence of Preterm Birth.

PubMed

Tielsch, James M

2015-01-01

Estimating the incidence of preterm birth depends on accurate assessment of gestational age and pregnancy outcomes. In many countries, such data are not routinely collected, making global estimates difficult. A recent systematic approach to this problem has estimated a worldwide incidence of 11.1 per 100 live births in 2010. Significant variation in rates by country and region of the world was noted, but this variation is smaller than observed for a number of other important reproductive outcomes. Rates range from approximately 5% in some northern European countries to over 15% in some countries in sub-Saharan Africa and Asia. Time trends suggest that preterm birth incidence is increasing, but much of this change may reflect changes in medically induced early delivery practices as improvements in survival of preterm infants has improved. Whether there have been major changes in spontaneous preterm birth is unknown. New approaches to classifying etiologic heterogeneity have been proposed and offer the promise of developing specific interventions to address the range of underlying causes of this important health problem. © 2015 Nestec Ltd., Vevey/S. Karger AG, Basel.

Global geometry of non-planar 3-body motions

NASA Astrophysics Data System (ADS)

Salehani, Mahdi Khajeh

2011-12-01

The aim of this paper is to study the global geometry of non-planar 3-body motions in the realms of equivariant Differential Geometry and Geometric Mechanics. This work was intended as an attempt at bringing together these two areas, in which geometric methods play the major role, in the study of the 3-body problem. It is shown that the Euler equations of a three-body system with non-planar motion introduce non-holonomic constraints into the Lagrangian formulation of mechanics. Applying the method of undetermined Lagrange multipliers to study the dynamics of three-body motions reduced to the level of moduli space {bar{M}} subject to the non-holonomic constraints yields the generalized Euler-Lagrange equations of non-planar three-body motions in {bar{M}} . As an application of the derived dynamical equations in the level of {bar{M}} , we completely settle the question posed by A. Wintner in his book [The analytical foundations of Celestial Mechanics, Sections 394-396, 435 and 436. Princeton University Press (1941)] on classifying the constant inclination solutions of the three-body problem.

Why do the biotechnology and the climate change debates hardly mix? Evidence from a global stakeholder survey.

PubMed

Aerni, Philipp

2013-05-25

Despite its potential to address climate change problems, the role of biotechnology is hardly ever touched upon in the global sustainability debate. We wanted to know why. For that purpose, we conducted a global online stakeholder survey on biotechnology and climate change. The relevant stakeholders and their representatives were selected by means of key informants that were familiar with either of the two debates. A self-assessment showed that a majority of respondents felt more familiar with the climate change than the biotechnology debate. Even though the survey results reveal that most respondents consider the potential of modern biotechnology to address climate change to be substantial, the policy network analysis revealed that one stakeholder who is not just considered to be relevant in both debates but also crucial in the formation of global public opinion, strongly rejects the view that biotechnology is a climate-friendly and therefore clean technology. This influential opposition seems to ensure that the biotechnology and the climate change debates do not mix. Copyright © 2012 Elsevier B.V. All rights reserved.

An Actor-Network Theory Analysis of Policy Innovation for Smoke-Free Places: Understanding Change in Complex Systems

PubMed Central

Borland, Ron; Coghill, Ken

2010-01-01

Complex, transnational issues like the tobacco epidemic are major challenges that defy analysis and management by conventional methods, as are other public health issues, such as those associated with global food distribution and climate change. We examined the evolution of indoor smoke-free regulations, a tobacco control policy innovation, and identified the key attributes of those jurisdictions that successfully pursued this innovation and those that to date have not. In doing so, we employed the actor-network theory, a comprehensive framework for the analysis of fundamental system change. Through our analysis, we identified approaches to help overcome some systemic barriers to the solution of the tobacco problem and comment on other complex transnational problems. PMID:20466949

Domestic minor sex trafficking: what the PNP needs to know.

PubMed

Hornor, Gail

2015-01-01

Human trafficking is a major global public health problem and represents a substantial human rights violation. Human trafficking has been receiving attention in both the lay media and professional literature. Human trafficking can include commercial sex, forced labor, child soldiers, and stealing of human organs. One form of human trafficking represents a significant American pediatric health problem: domestic minor sex trafficking (DMST). DMST is the commercial sexual abuse of children by selling, buying, or trading their sexual service. This continuing education article will define DMST and discuss it in terms of prevalence, risk factors, and practice implications for the pediatric nurse practitioner. Copyright © 2015 National Association of Pediatric Nurse Practitioners. Published by Elsevier Inc. All rights reserved.

An actor-network theory analysis of policy innovation for smoke-free places: understanding change in complex systems.

PubMed

Young, David; Borland, Ron; Coghill, Ken

2010-07-01

Complex, transnational issues like the tobacco epidemic are major challenges that defy analysis and management by conventional methods, as are other public health issues, such as those associated with global food distribution and climate change. We examined the evolution of indoor smoke-free regulations, a tobacco control policy innovation, and identified the key attributes of those jurisdictions that successfully pursued this innovation and those that to date have not. In doing so, we employed the actor-network theory, a comprehensive framework for the analysis of fundamental system change. Through our analysis, we identified approaches to help overcome some systemic barriers to the solution of the tobacco problem and comment on other complex transnational problems.

The global problem of blindness and visual dysfunction

NASA Astrophysics Data System (ADS)

Lakshminarayanan, Vasudevan

2012-10-01

According to World Health Organization statistics there are approximately 285 million people who are blind, have severe low vision, or are near-blind. Of these, 39 million are blind, and 246 million have low vision problems. About 90% of these live in developing countries. The major causes are uncorrected refractive errors (42%), and cataracts (38%). In the US, there are about 6 million people over the age of 65 who have age-related macular degeneration which is the leading cause of blindness. For each decade after age 40, it is found that there is a three-fold increase in the prevalence of blindness and low vision. This paper will address the question of what can we, as optical physicists and engineers, do? There is a need for efficient methods to detect problems, investigate function, provide solutions, and develop rehabilitation devices for the visually impaired. Here I will sketch out the magnitude and variety of the problem, examples and future research directions.

Constraint-based stereo matching

NASA Technical Reports Server (NTRS)

Kuan, D. T.

1987-01-01

The major difficulty in stereo vision is the correspondence problem that requires matching features in two stereo images. Researchers describe a constraint-based stereo matching technique using local geometric constraints among edge segments to limit the search space and to resolve matching ambiguity. Edge segments are used as image features for stereo matching. Epipolar constraint and individual edge properties are used to determine possible initial matches between edge segments in a stereo image pair. Local edge geometric attributes such as continuity, junction structure, and edge neighborhood relations are used as constraints to guide the stereo matching process. The result is a locally consistent set of edge segment correspondences between stereo images. These locally consistent matches are used to generate higher-level hypotheses on extended edge segments and junctions to form more global contexts to achieve global consistency.

A Case-Based, Problem-Based Learning Approach to Prepare Master of Public Health Candidates for the Complexities of Global Health

PubMed Central

Winskell, Kate; McFarland, Deborah A.; del Rio, Carlos

2015-01-01

Global health is a dynamic, emerging, and interdisciplinary field. To address current and emerging global health challenges, we need a public health workforce with adaptable and collaborative problem-solving skills. In the 2013–2014 academic year, the Hubert Department of Global Health at the Rollins School of Public Health–Emory University launched an innovative required core course for its first-year Master of Public Health students in the global health track. The course uses a case-based, problem-based learning approach to develop global health competencies. Small teams of students propose solutions to these problems by identifying learning issues and critically analyzing and synthesizing new information. We describe the course structure and logistics used to apply this approach in the context of a large class and share lessons learned. PMID:25706029

Microbial Etiology of Pneumonia: Epidemiology, Diagnosis and Resistance Patterns.

PubMed

Cilloniz, Catia; Martin-Loeches, Ignacio; Garcia-Vidal, Carolina; San Jose, Alicia; Torres, Antoni

2016-12-16

Globally, pneumonia is a serious public health concern and a major cause of mortality and morbidity. Despite advances in antimicrobial therapies, microbiological diagnostic tests and prevention measures, pneumonia remains the main cause of death from infectious disease in the world. An important reason for the increased global mortality is the impact of pneumonia on chronic diseases, along with the increasing age of the population and the virulence factors of the causative microorganism. The increasing number of multidrug-resistant bacteria, difficult-to-treat microorganisms, and the emergence of new pathogens are a major problem for clinicians when deciding antimicrobial therapy. A key factor for managing and effectively guiding appropriate antimicrobial therapy is an understanding of the role of the different causative microorganisms in the etiology of pneumonia, since it has been shown that the adequacy of initial antimicrobial therapy is a key factor for prognosis in pneumonia. Furthermore, broad-spectrum antibiotic therapies are sometimes given until microbiological results are available and de-escalation cannot be performed quickly. This review provides an overview of microbial etiology, resistance patterns, epidemiology and microbial diagnosis of pneumonia.

Job Scheduling in a Heterogeneous Grid Environment

NASA Technical Reports Server (NTRS)

Shan, Hong-Zhang; Smith, Warren; Oliker, Leonid; Biswas, Rupak

2004-01-01

Computational grids have the potential for solving large-scale scientific problems using heterogeneous and geographically distributed resources. However, a number of major technical hurdles must be overcome before this potential can be realized. One problem that is critical to effective utilization of computational grids is the efficient scheduling of jobs. This work addresses this problem by describing and evaluating a grid scheduling architecture and three job migration algorithms. The architecture is scalable and does not assume control of local site resources. The job migration policies use the availability and performance of computer systems, the network bandwidth available between systems, and the volume of input and output data associated with each job. An extensive performance comparison is presented using real workloads from leading computational centers. The results, based on several key metrics, demonstrate that the performance of our distributed migration algorithms is significantly greater than that of a local scheduling framework and comparable to a non-scalable global scheduling approach.

Free Mesh Method: fundamental conception, algorithms and accuracy study

PubMed Central

YAGAWA, Genki

2011-01-01

The finite element method (FEM) has been commonly employed in a variety of fields as a computer simulation method to solve such problems as solid, fluid, electro-magnetic phenomena and so on. However, creation of a quality mesh for the problem domain is a prerequisite when using FEM, which becomes a major part of the cost of a simulation. It is natural that the concept of meshless method has evolved. The free mesh method (FMM) is among the typical meshless methods intended for particle-like finite element analysis of problems that are difficult to handle using global mesh generation, especially on parallel processors. FMM is an efficient node-based finite element method that employs a local mesh generation technique and a node-by-node algorithm for the finite element calculations. In this paper, FMM and its variation are reviewed focusing on their fundamental conception, algorithms and accuracy. PMID:21558752

Intensive Evening Outpatient Treatment for Patients With Personality Dysfunction: Early Group Process, Change in Interpersonal Distress, and Longer-Term Social Functioning.

PubMed

Joyce, Anthony S; Ogrodniczuk, John S; Kealy, David

2017-01-01

Entrenched interpersonal difficulties are a defining feature of those with personality dysfunction. Evening treatment-a comprehensive and intensive group-oriented outpatient therapy program-offers a unique approach to delivering mental health services to patients with chronic personality dysfunction. This study assessed change in interpersonal problems as a key outcome, the relevance of such change to future social functioning, and the influence of early group processes on this change. Consecutively admitted patients (N = 75) to a group-oriented evening treatment program were recruited; the majority were diagnosed with personality disorder. Therapy outcome was represented by scores on the Inventory of Interpersonal Problems. Follow-up outcome was represented by the global score of the Social Adjustment Scale. Group climate, group cohesion, and the therapeutic alliance were examined as process variables. Patients experienced substantial reduction in distress associated with interpersonal problems; early process factors that reflected a cohesive and engaged group climate and stronger therapeutic alliance were predictive of this outcome. Improvement in interpersonal distress was predictive of global social functioning six months later. The therapeutic alliance most strongly accounted for change in interpersonal problems at posttreatment and social functioning at follow-up. A comprehensive and integrated outpatient group therapy program, offered in the evening to accommodate patients' real-life demands, can facilitate considerable improvement in interpersonal problems, which in turn influences later social functioning. The intensity and intimacy of peer interactions in the therapy groups, and a strong alliance with the program therapists, are likely interacting factors that are particularly important to facilitate such change.

Environmental health in China: challenges to achieving clean air and safe water

PubMed Central

Zhang, Junfeng (Jim); Mauzerall, Denise L.; Zhu, Tong; Liang, Song; Ezzati, Majid; Remais, Justin

2014-01-01

The health effects of environmental risks, especially those of air and water pollution, remain a major source of morbidity and mortality in China. Biomass fuel and coal are routinely burned for cooking and heating in almost all rural and many urban households resulting in severe indoor air pollution that contributes greatly to the burden of disease. Many communities lack access to safe drinking water and santiation, and thus the risk of waterborne disease in many regions remains high. At the same time, China is rapidly industrializing with associated increases in energy use and industrial waste. While economic growth resulting from industrialization has improved health and quality of life indicators in China, it has also increased the incidence of environmental disasters and the release of chemical toxins into the environment, with severe impacts on health. Air quality in China's cities is among the worst in the world and industrial water pollution has become a widespread health hazard. Moreover, emissions of climate-warming greenhouse gases from energy use are rapidly increasing. Global climate change will inevitably intensify China's environmental health problems, with potentially catastrophic outcomes from major shifts in temperature and precipitation. Facing the overlap of traditional, modern, and emerging environmental problems, China has committed substantial resources to environmental improvement. China has the opportunity to both address its national environmental health challenges and to assume a central role in the international effort to improve the global environment. PMID:20346817

Restorative Justice Practice: Cooperative Problem-Solving in New Zealand's Schools

ERIC Educational Resources Information Center

Drewery, Wendy

2013-01-01

This article links capability for cooperative problem-solving with socially just global development. From the perspective of the United Nations Development Programme, the work of global development, founded on a concept of global justice, is capability-building. Following Kurasawa, the article proposes that this form of global justice is enacted…

LDRD Final Report: Global Optimization for Engineering Science Problems

DOE Office of Scientific and Technical Information (OSTI.GOV)

HART,WILLIAM E.

1999-12-01

For a wide variety of scientific and engineering problems the desired solution corresponds to an optimal set of objective function parameters, where the objective function measures a solution's quality. The main goal of the LDRD ''Global Optimization for Engineering Science Problems'' was the development of new robust and efficient optimization algorithms that can be used to find globally optimal solutions to complex optimization problems. This SAND report summarizes the technical accomplishments of this LDRD, discusses lessons learned and describes open research issues.

Global Coordinates and Exact Aberration Calculations Applied to Physical Optics Modeling of Complex Optical Systems

NASA Astrophysics Data System (ADS)

Lawrence, G.; Barnard, C.; Viswanathan, V.

1986-11-01

Historically, wave optics computer codes have been paraxial in nature. Folded systems could be modeled by "unfolding" the optical system. Calculation of optical aberrations is, in general, left for the analyst to do with off-line codes. While such paraxial codes were adequate for the simpler systems being studied 10 years ago, current problems such as phased arrays, ring resonators, coupled resonators, and grazing incidence optics require a major advance in analytical capability. This paper describes extension of the physical optics codes GLAD and GLAD V to include a global coordinate system and exact ray aberration calculations. The global coordinate system allows components to be positioned and rotated arbitrarily. Exact aberrations are calculated for components in aligned or misaligned configurations by using ray tracing to compute optical path differences and diffraction propagation. Optical path lengths between components and beam rotations in complex mirror systems are calculated accurately so that coherent interactions in phased arrays and coupled devices may be treated correctly.

Medicalization of global health 2: The medicalization of global mental health.

PubMed

Clark, Jocalyn

2014-01-01

Once an orphan field, 'global mental health' now has wide acknowledgement and prominence on the global health agenda. Increased recognition draws needed attention to individual suffering and the population impacts, but medicalizing global mental health produces a narrow view of the problems and solutions. Early framing by advocates of the global mental health problem emphasised biological disease, linked psychiatry with neurology, and reinforced categories of mental health disorders. Universality of biomedical concepts across culture is assumed in the globalisation of mental health but is strongly disputed by transcultural psychiatrists and anthropologists. Global mental health movement priorities take an individualised view, emphasising treatment and scale-up and neglecting social and structural determinants of health. To meet international targets and address the problem's broad social and cultural dimensions, the global mental health movement and advocates must develop more comprehensive strategies and include more diverse perspectives.

Medicalization of global health 2: the medicalization of global mental health

PubMed Central

Clark, Jocalyn

2014-01-01

Once an orphan field, ‘global mental health’ now has wide acknowledgement and prominence on the global health agenda. Increased recognition draws needed attention to individual suffering and the population impacts, but medicalizing global mental health produces a narrow view of the problems and solutions. Early framing by advocates of the global mental health problem emphasised biological disease, linked psychiatry with neurology, and reinforced categories of mental health disorders. Universality of biomedical concepts across culture is assumed in the globalisation of mental health but is strongly disputed by transcultural psychiatrists and anthropologists. Global mental health movement priorities take an individualised view, emphasising treatment and scale-up and neglecting social and structural determinants of health. To meet international targets and address the problem's broad social and cultural dimensions, the global mental health movement and advocates must develop more comprehensive strategies and include more diverse perspectives. PMID:24848660

Attributional processes in the learned helplessness paradigm: behavioral effects of global attributions.

PubMed

Mikulincer, M

1986-12-01

Following the learned helplessness paradigm, I assessed in this study the effects of global and specific attributions for failure on the generalization of performance deficits in a dissimilar situation. Helplessness training consisted of experience with noncontingent failures on four cognitive discrimination problems attributed to either global or specific causes. Experiment 1 found that performance in a dissimilar situation was impaired following exposure to globally attributed failure. Experiment 2 examined the behavioral effects of the interaction between stable and global attributions of failure. Exposure to unsolvable problems resulted in reduced performance in a dissimilar situation only when failure was attributed to global and stable causes. Finally, Experiment 3 found that learned helplessness deficits were a product of the interaction of global and internal attribution. Performance deficits following unsolvable problems were recorded when failure was attributed to global and internal causes. Results were discussed in terms of the reformulated learned helplessness model.

Antimicrobial Resistance in Neisseria gonorrhoeae in the 21st Century: Past, Evolution, and Future

PubMed Central

Unemo, Magnus

2014-01-01

SUMMARY Neisseria gonorrhoeae is evolving into a superbug with resistance to previously and currently recommended antimicrobials for treatment of gonorrhea, which is a major public health concern globally. Given the global nature of gonorrhea, the high rate of usage of antimicrobials, suboptimal control and monitoring of antimicrobial resistance (AMR) and treatment failures, slow update of treatment guidelines in most geographical settings, and the extraordinary capacity of the gonococci to develop and retain AMR, it is likely that the global problem of gonococcal AMR will worsen in the foreseeable future and that the severe complications of gonorrhea will emerge as a silent epidemic. By understanding the evolution, emergence, and spread of AMR in N. gonorrhoeae, including its molecular and phenotypic mechanisms, resistance to antimicrobials used clinically can be anticipated, future methods for genetic testing for AMR might permit region-specific and tailor-made antimicrobial therapy, and the design of novel antimicrobials to circumvent the resistance problems can be undertaken more rationally. This review focuses on the history and evolution of gonorrhea treatment regimens and emerging resistance to them, on genetic and phenotypic determinants of gonococcal resistance to previously and currently recommended antimicrobials, including biological costs or benefits; and on crucial actions and future advances necessary to detect and treat resistant gonococcal strains and, ultimately, retain gonorrhea as a treatable infection. PMID:24982323

Research on Globalization and Education

ERIC Educational Resources Information Center

Spring, Joel

2008-01-01

Research on globalization and education involves the study of intertwined worldwide discourses, processes, and institutions affecting local educational practices and policies. The four major theoretical perspectives concerning globalization and education are world culture, world systems, postcolonial, and culturalist. The major global educational…

Teaching Physics to Environmental Science Majors Using a Flipped Course Approach

NASA Astrophysics Data System (ADS)

Hill, N. B.; Riha, S. J.; Wysocki, M. W.

2014-12-01

Coursework in physics provides a framework for quantitative reasoning and problem solving skill development in budding geoscientists. To make physical concepts more accessible and relevant to students majoring in environmental science, an environmental physics course was developed at Cornell University and offered for the first time during spring 2014. Principles of radiation, thermodynamics, and mechanics were introduced and applied to the atmosphere, hydrosphere, and lithosphere to describe energy and mass transfers in natural and built environments. Environmental physics was designed as a flipped course where students viewed online material outside of class and worked in groups in class to solve sustainability problems. Experiential learning, just-in-time teaching, and peer collaboration strategies were also utilized. In-class problems were drawn from both local and global environmental sustainability concerns. Problems included an investigation of Cornell's lake source cooling system, calculations on the energy consumed in irrigation with groundwater in the southwestern United States, and power generated by wind turbines at various locations around the world. Class attendance was high, with at least 84% of students present at each meeting. Survey results suggest that students enjoyed working in groups and found the in-class problems helpful for assimilating the assigned material. However, some students reported that the workload was too heavy and they preferred traditional lectures to the flipped classroom. The instructors were able to actively engage with students and quickly identify knowledge and skill gaps that needed to be addressed. Overall, the integration of current environmental problems and group work into an introductory physics course could help to inspire and motivate students as they advance their ability to analyze problems quantitatively.

Selected psychiatric problems among college students in two Arab countries: comparison with the USA.

PubMed

Kronfol, Ziad; Khalifa, Batoul; Khoury, Brigitte; Omar, Omar; Daouk, Sariah; deWitt, J P; ElAzab, Nourehan; Eisenberg, Daniel

2018-05-24

Psychiatric problems among college students on USA campuses are common. Little is known about similar problems in developing countries, particularly the Arab region. The goal of this study was to assess the frequency of selected psychiatric problems among college students in two Arab countries: Qatar and Lebanon, and to compare them to the USA. The Healthy Minds Study, an online confidential survey of common psychiatric symptoms designed for college campuses was used. We used the Patient Health Questionnaire-9 (PHQ-9) to screen for major depression, the Generalized Anxiety Disorder-7 (GAD-7) to screen for generalized anxiety and the SCOFF questionnaire to screen for eating disorders. Comparisons were made using ANOVA, Chi-Square tests and logistic regressions. A total of 1841 students participated in the study. The rates of depression (PHQ-9 ≥ 12), generalized anxiety (GAD-7 ≥ 10) and eating disorders (SCOFF≥3) at the combined Arab universities were 34.6, 36.1 and 20.4% respectively. The corresponding rates in the USA were: 12.8, 15.9 and 6.8% (p < 0.001 for all measures). The impact of psychiatric problems on functioning in general and academic performance in particular was more severe in the Arab countries compared to the USA (p < 0.001). Independent predictors of psychiatric problems in general included location, female gender, financial difficulties and poor grades. Being religious had a protective association with mental health. The rates of depression, anxiety and eating disorders were significantly higher among college students in Qatar and Lebanon compared to the USA. Additional research is needed to determine whether these results reflect methodological limitations or true differences in psychopathology across these populations. If replicated, the results indicate that the psychiatric problems on college campuses in the USA are a microcosm of a global problem that needs global solutions.

Elder Abuse: Systematic Review and Implications for Practice.

PubMed

Dong, Xin Qi

2015-06-01

This article is based on the lecture for the 2014 American Geriatrics Society Outstanding Scientific Achievement for Clinical Investigation Award. Elder abuse is a global public health and human rights problem. Evidence suggests that elder abuse is prevalent, predictable, costly, and sometimes fatal. This review will highlight the global epidemiology of elder abuse in terms of its prevalence, risk factors, and consequences in community populations. The global literature in PubMed, MEDLINE, PsycINFO, BIOSIS, Science Direct, and Cochrane Central was searched. Search terms included elder abuse, elder mistreatment, elder maltreatment, prevalence, incidence, risk factors, protective factors, outcomes, and consequences. Studies that existed only as abstracts, case series, or case reports or recruited individuals younger than 60; qualitative studies; and non-English publications were excluded. Tables and figures were created to highlight the findings: the most-detailed analyses to date of the prevalence of elder abuse according to continent, risk and protective factors, graphic presentation of odds ratios and confidence intervals for major risk factors, consequences, and practical suggestions for health professionals in addressing elder abuse. Elder abuse is common in community-dwelling older adults, especially minority older adults. This review identifies important knowledge gaps, such as a lack of consistency in definitions of elder abuse; insufficient research with regard to screening; and etiological, intervention, and prevention research. Concerted efforts from researchers, community organizations, healthcare and legal professionals, social service providers, and policy-makers should be promoted to address the global problem of elder abuse. © 2015, Copyright the Author Journal compilation © 2015, The American Geriatrics Society.

Carbapenem Resistance: A Review

PubMed Central

Codjoe, Francis S.; Donkor, Eric S.

2017-01-01

Carbapenem resistance is a major and an on-going public health problem globally. It occurs mainly among Gram-negative pathogens such as Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii, and may be intrinsic or mediated by transferable carbapenemase-encoding genes. This type of resistance genes are already widespread in certain parts of the world, particularly Europe, Asia and South America, while the situation in other places such as sub-Saharan Africa is not well documented. In this paper, we provide an in-depth review of carbapenem resistance providing up-to-date information on the subject. PMID:29267233

[Dengue shock syndrome].

PubMed

Docquir, J; Tuerlinckx, D; Bodart, E

2009-11-01

Célia, 21 month-old child, presented to our pediatric clinic a few months ago with a fever of unknown origin after a stay in St-Domingue with her parents. Complementary investigations led to a diagnosis of Dengue Fever. The condition, not very frequent and thus not well known in our countries, represents a major world health problem especially because of the global failure of prophylactic measures. If the disease is self-limited in most cases, severe form can occur, with significant mortality and morbidity. Delay in diagnosis and treatment of these severe cases is often fatal.

Recent progress in Precambrian paleobiology

NASA Technical Reports Server (NTRS)

Schopf, J. W.

1986-01-01

Ongoing studies at UCLA include the following: (1) investigations in Archean and Proterozoic sequences of various locations; (2) laboratory and field studies of modern microbial biocoenoses (analogues of Precambrian microbial communities) especially those at Laguna Mormona, Baja California, Mexico; (3) development of new laboratory techniques for the separation and concentration of minute cellularly preserved fossils for isotopic and organic geochemical analyses; and (4) assembly of a computerized database for assessment of the timing and nature of major events occurring during Precambrian biotic evolution, and of the potential applicability of ancient microbiotas to problems of global biostratigraphy and biogeography.

Impacts of ENSO on global hydrology

NASA Astrophysics Data System (ADS)

Ward, P. J.; Eisner, S.; Flörke, M.; Kummu, M.

2012-04-01

The economic consequences of flooding are huge, as exemplified by recent major floods in Thailand, Pakistan, and Australia. Moreover, research shows that economic losses due to flooding have increased dramatically in recent decades. Whilst much research is being carried out to assess how this may be related to socioeconomic development (increased exposure to floods) or climate change (increased hazard), the role of interannual climate variability is poorly understood at the global scale. We provide the first global assessment of the sensitivity of extreme global river discharge to the El Niño Southern Oscillation (ENSO). Past studies have either: (a) assessed this at the local scale; or (b) assessed only global correlations between ENSO and mean river discharge. Firstly, we used a daily observed discharge dataset for 622 gauging stations (from the GRDC database), and assessed and mapped correlations and sensitivities between these time-series and several indices of ENSO. We found that, on average, for the stations studied ENSO has a greater impact on annual high-flow events than on mean annual discharge, especially in the extra-tropics. However, the geographical coverage of the dataset is poor in some regions, and is highly skewed towards certain areas (e.g. North America, Europe, and eastern Australia). This renders a truly global assessment of ENSO impacts impossible based on these observed time-series. Hence, we are also using a modelling approach to estimate correlations and sensitivities in all basins, gauged and ungauged. For this, we are using a gridded time-series of modelled daily discharge from the EU-WATCH project, and analysing relationships between these time-series (per grid-cell) and indices of ENSO. This allows for the first truly global assessment of the impact of ENSO variability on river discharge; these analyses are ongoing. Of course, this approach entails its own problems; the use of global hydrological models to derive daily discharge time-series introduces its own uncertainties. Hence, the results derived from the modelling exercise will be validated against the results derived from the observed data. The quantification of ENSO impacts provides relevant information for water management, allowing the identification of problem areas and providing a basis for risk assessments.

Interdisciplinary Analysis and Global Policy Studies.

ERIC Educational Resources Information Center

Meeks, Philip

This paper examines ways in which interdisciplinary and multidisciplinary analysis of global policy studies can increase understanding of complex global problems. Until recently, social science has been the discipline most often turned to for techniques and methodology to analyze social problems and behaviors. However, because social science…

A case study of global health at the university: implications for research and action.

PubMed

Pinto, Andrew D; Cole, Donald C; ter Kuile, Aleida; Forman, Lisa; Rouleau, Katherine; Philpott, Jane; Pakes, Barry; Jackson, Suzanne; Muntaner, Carles

2014-01-01

Global health is increasingly a major focus of institutions in high-income countries. However, little work has been done to date to study the inner workings of global health at the university level. Academics may have competing objectives, with few mechanisms to coordinate efforts and pool resources. To conduct a case study of global health at Canada's largest health sciences university and to examine how its internal organization influences research and action. We drew on existing inventories, annual reports, and websites to create an institutional map, identifying centers and departments using the terms 'global health' or 'international health' to describe their activities. We compiled a list of academics who self-identified as working in global or international health. We purposively sampled persons in leadership positions as key informants. One investigator carried out confidential, semi-structured interviews with 20 key informants. Interview notes were returned to participants for verification and then analyzed thematically by pairs of coders. Synthesis was conducted jointly. More than 100 academics were identified as working in global health, situated in numerous institutions, centers, and departments. Global health academics interviewed shared a common sense of what global health means and the values that underpin such work. Most academics interviewed expressed frustration at the existing fragmentation and the lack of strategic direction, financial support, and recognition from the university. This hampered collaborative work and projects to tackle global health problems. The University of Toronto is not exceptional in facing such challenges, and our findings align with existing literature that describes factors that inhibit collaboration in global health work at universities. Global health academics based at universities may work in institutional siloes and this limits both internal and external collaboration. A number of solutions to address these challenges are proposed.

The effect of wind and moisture gradients on the arbitrary assignment of cloud motions to a vertical coordinate system in two Sesame cases

NASA Technical Reports Server (NTRS)

Peslen, C. A.; Koch, S. E.; Uccellini, L. W.

1984-01-01

Satellite-derived cloud motion 'wind' vectors (CMV) are increasingly used in mesoscale and in global analyses, and questions have been raised regarding the uncertainty of the level assignment for the CMV. One of two major problems in selecting a level for the CMV is related to uncertainties in assigning the motion vector to either the cloud top or base. The second problem is related to the inability to transfer the 'wind' derived from the CMV at individually specified heights to a standard coordinated surface. The present investigation has the objective to determine if the arbitrary level assignment represents a serious obstacle to the use of cloud motion wind vectors in the mesoscale analysis of a severe storm environment.

The Complexities of Implementing Cluster Supply Chain - Case Study of JCH

NASA Astrophysics Data System (ADS)

Xue, Xiao; Zhang, Jibiao; Wang, Yang

As a new type of management pattern, "cluster supply chain" (CSC) can help SMEs to face the global challenges through all kinds of collaboration. However, a major challenge in implementing CSC is the gap between theory and practice in the field. In an effort to provide a better understanding of this emerging phenomenon, this paper presents the implementation process of CSC in the context of JingCheng Mechanical & Electrical Holding co., ltd.(JCH) as a case study. The cast study of JCH suggests that the key problems in the practice of cluster supply chain: How do small firms use cluster supply chain? Only after we clarify the problem, the actual construction and operation of cluster supply chain does show successful results as it should be.

Continuous-time system identification of a smoking cessation intervention

NASA Astrophysics Data System (ADS)

Timms, Kevin P.; Rivera, Daniel E.; Collins, Linda M.; Piper, Megan E.

2014-07-01

Cigarette smoking is a major global public health issue and the leading cause of preventable death in the United States. Toward a goal of designing better smoking cessation treatments, system identification techniques are applied to intervention data to describe smoking cessation as a process of behaviour change. System identification problems that draw from two modelling paradigms in quantitative psychology (statistical mediation and self-regulation) are considered, consisting of a series of continuous-time estimation problems. A continuous-time dynamic modelling approach is employed to describe the response of craving and smoking rates during a quit attempt, as captured in data from a smoking cessation clinical trial. The use of continuous-time models provide benefits of parsimony, ease of interpretation, and the opportunity to work with uneven or missing data.

SEACAS Theory Manuals: Part III. Finite Element Analysis in Nonlinear Solid Mechanics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Laursen, T.A.; Attaway, S.W.; Zadoks, R.I.

1999-03-01

This report outlines the application of finite element methodology to large deformation solid mechanics problems, detailing also some of the key technological issues that effective finite element formulations must address. The presentation is organized into three major portions: first, a discussion of finite element discretization from the global point of view, emphasizing the relationship between a virtual work principle and the associated fully discrete system, second, a discussion of finite element technology, emphasizing the important theoretical and practical features associated with an individual finite element; and third, detailed description of specific elements that enjoy widespread use, providing some examples ofmore » the theoretical ideas already described. Descriptions of problem formulation in nonlinear solid mechanics, nonlinear continuum mechanics, and constitutive modeling are given in three companion reports.« less

A Review On Missing Value Estimation Using Imputation Algorithm

NASA Astrophysics Data System (ADS)

Armina, Roslan; Zain, Azlan Mohd; Azizah Ali, Nor; Sallehuddin, Roselina

2017-09-01

The presence of the missing value in the data set has always been a major problem for precise prediction. The method for imputing missing value needs to minimize the effect of incomplete data sets for the prediction model. Many algorithms have been proposed for countermeasure of missing value problem. In this review, we provide a comprehensive analysis of existing imputation algorithm, focusing on the technique used and the implementation of global or local information of data sets for missing value estimation. In addition validation method for imputation result and way to measure the performance of imputation algorithm also described. The objective of this review is to highlight possible improvement on existing method and it is hoped that this review gives reader better understanding of imputation method trend.

15 CFR 917.21 - National needs and problems.

Code of Federal Regulations, 2012 CFR

2012-01-01

... and problems with respect to ocean and coastal resources:global and regional climate and primary... global sea-level change and determine the impact of this change on coastal areas. (3) Define the... relationship to fluctuations in global and regional climate, primary productivity, and fisheries production. (4...

15 CFR 917.21 - National needs and problems.

Code of Federal Regulations, 2014 CFR

2014-01-01

... and problems with respect to ocean and coastal resources:global and regional climate and primary... global sea-level change and determine the impact of this change on coastal areas. (3) Define the... relationship to fluctuations in global and regional climate, primary productivity, and fisheries production. (4...

15 CFR 917.21 - National needs and problems.

Code of Federal Regulations, 2013 CFR

2013-01-01

... and problems with respect to ocean and coastal resources:global and regional climate and primary... global sea-level change and determine the impact of this change on coastal areas. (3) Define the... relationship to fluctuations in global and regional climate, primary productivity, and fisheries production. (4...

15 CFR 917.21 - National needs and problems.

Code of Federal Regulations, 2010 CFR

2010-01-01

... and problems with respect to ocean and coastal resources:global and regional climate and primary... global sea-level change and determine the impact of this change on coastal areas. (3) Define the... relationship to fluctuations in global and regional climate, primary productivity, and fisheries production. (4...

Necessary conditions for the globalization of traditional Chinese medicine.

PubMed

Yu, Bei-Bei; Gong, Xiu-Lin

2011-03-01

With the current trend of globalization, unprecedented opportunities and enormous changes have emerged for the global development of traditional Chinese medicine (TCM). However, many old and new challenges and problems still remain, including partial or limited comprehension of acupuncture, oriental medicine and TCM, the existence of non-standardized institutes of TCM and acupuncture training schools, unqualified TCM practitioners, and problems concerning Chinese herbal medicine and inexperience in conducting TCM business. These problems will doubtlessly impede the further development of TCM worldwide in the foreseeable future. It is also clear that the globalization of TCM will require a large scale systematic project and constitute an arduous historical task. This paper aims to consolidate 6 strategic development modes to reinforce and facilitate the process of TCM globalization through a detailed analysis of both the present status and existing problems concerning the development of TCM in the United States.

Basis for application of criteria for definition of Global Heritage Stone

NASA Astrophysics Data System (ADS)

Marker, Brian

2013-04-01

The Global Heritage Stone designation has been proposed to assist geoscientists, planners and the industry in explaining the importance of some types of stone in repair and maintenance of historic structures, new buildings and objects such as sculptures. The designation will have value only if rigorous criteria are used in accepting proposals and the designation is not used too liberally. Criteria proposed by the Heritage Stone Task Group relate, in brief, to wide use of stone either internationally or for major cultural monuments for a period of at least 50 years. However it is not always easy to determine what is truly international or what is of sufficient cultural or artistic merit. This contribution provides some examples of possible problems as a basis for discussion on the refinement of application of the criteria.

Repurposing psychiatric drugs as anti-cancer agents.

PubMed

Huang, Jing; Zhao, Danwei; Liu, Zhixiong; Liu, Fangkun

2018-04-10

Cancer is a major public health problem and one of the leading contributors to the global disease burden. The high cost of development of new drugs and the increasingly severe burden of cancer globally have led to increased interest in the search and development of novel, affordable anti-neoplastic medications. Antipsychotic drugs have a long history of clinical use and tolerable safety; they have been used as good targets for drug repurposing. Being used for various psychiatric diseases for decades, antipsychotic drugs are now reported to have potent anti-cancer properties against a wide variety of malignancies in addition to their antipsychotic effects. In this review, an overview of repurposing various psychiatric drugs for cancer treatment is presented, and the putative mechanisms for the anti-neoplastic actions of these antipsychotic drugs are reviewed. Copyright © 2018 Elsevier B.V. All rights reserved.

Parameter estimation of a pulp digester model with derivative-free optimization strategies

NASA Astrophysics Data System (ADS)

Seiça, João C.; Romanenko, Andrey; Fernandes, Florbela P.; Santos, Lino O.; Fernandes, Natércia C. P.

2017-07-01

The work concerns the parameter estimation in the context of the mechanistic modelling of a pulp digester. The problem is cast as a box bounded nonlinear global optimization problem in order to minimize the mismatch between the model outputs with the experimental data observed at a real pulp and paper plant. MCSFilter and Simulated Annealing global optimization methods were used to solve the optimization problem. While the former took longer to converge to the global minimum, the latter terminated faster at a significantly higher value of the objective function and, thus, failed to find the global solution.

Geophysical Tools, Challenges and Perspectives Related to Natural Hazards, Climate Change and Food Security

NASA Astrophysics Data System (ADS)

Fucugauchi, J. U.

2013-05-01

In the coming decades a changing climate and natural hazards will likely increase the vulnerability of agricultural and other food production infrastructures, posing increasing treats to industrialized and developing economies. While food security concerns affect us globally, the huge differences among countries in stocks, population size, poverty levels, economy, technologic development, transportation, health care systems and basic infrastructure will pose a much larger burden on populations in the developing and less developed world. In these economies, increase in the magnitude, duration and frequency of droughts, floods, hurricanes, rising sea levels, heat waves, thunderstorms, freezing events and other phenomena will pose severe costs on the population. For this presentation, we concentrate on a geophysical perspective of the problems, tools available, challenges and short and long-term perspectives. In many instances, a range of natural hazards are considered as unforeseen catastrophes, which suddenly affect without warning, resulting in major losses. Although the forecasting capacity in the different situations arising from climate change and natural hazards is still limited, there are a range of tools available to assess scenarios and forecast models for developing and implementing better mitigation strategies and prevention programs. Earth observation systems, geophysical instrumental networks, satellite observatories, improved understanding of phenomena, expanded global and regional databases, geographic information systems, higher capacity for computer modeling, numerical simulations, etc provide a scientific-technical framework for developing strategies. Hazard prevention and mitigation programs will result in high costs globally, however major costs and challenges concentrate on the less developed economies already affected by poverty, famines, health problems, social inequalities, poor infrastructure, low life expectancy, high population growth, inadequate education systems, immigration, economic crises, conflicts and other issues. Case history analyses and proposals for collaboration programs, know-how transfer and better use of geophysical tools, data, observatories and monitoring networks will be discussed.

College of Business Majors' Perceptions toward Globalization: An Empirical Study

ERIC Educational Resources Information Center

Janavaras, Basil; Kuzma, John; Thiewes, Harold

2008-01-01

The objective of this paper is to determine the extent to which business majors' attitudes towards globalization are influenced by the area of selected study. Research has documented that more favorable attitudes towards globalization are found among college students, and specifically, these more favorable attitudes are found in business majors.…

Effects of global change on hydro-geomorphological hazards in Mediterranean rivers

NASA Astrophysics Data System (ADS)

Andres Lopez-Tarazon, Jose

2015-04-01

Mediterranean river basins are characterized by high (often extreme) temporal variability in precipitation, and hence discharge. Mediterranean countries are considered sensitive to so-called global change, considered as the combination of climate and land use changes. All panels on climate evolution predict future scenarios of increasing frequency and magnitude of floods and extended droughts in the Mediterranean region; both floods and droughts are likely to lead to huge geomorphic adjustments of river channels so, major metamorphosis of fluvial systems is expected as a result of global change. Water resources in the Mediterranean region is subjected to rising pressures, becoming a key issue for all governments (i.e. clear imbalance between the available water resources and the increasing water demand related to increasing human population). Such pressures are likely to give rise to major ecological and economic changes and challenges that governments need to address as a matter of priority. Changes in river flow regimes associated with global change are therefore ushering in a new era, where there is a critical need to evaluate hydro-geomorphological hazard from headwaters to lowland areas (flooding can be not just a problem related to being under the water). A key question is how our understanding of these hazards associated with global change can be improved; improvement has to come from integrated research which includes all physical conditions that influence the conveyance of water and sediments, and the river's capacity (i.e. amount of sediment) and competence (i.e. channel deformation) that, in turn, will influence physical conditions of a given point in the river network. This is the framework of the present work; it is directed to develop an integrated approach which both improves our understanding of how rivers are likely to evolve as a result of global change, and addresses the associated hazards of fluvial environmental change.

Building a strong geoscience department by emphasizing curriculum and pedagogy

NASA Astrophysics Data System (ADS)

Lea, P. D.; Beane, R. J.; Laine, E. P.

2005-12-01

About a decade ago the Bowdoin College Geology Department recognized a need for a new curriculum that more fully engaged majors and non-majors as active learners. To accomplish this curricular change the faculty have adopted differing pedagogies that all engage students in real projects. Research project-based learning, community-based learning, and problem-based service-learning form the core of our teaching efforts. The emphasis on problem-solving and inquiry in our courses has greatly strengthened our department's contributions to research, education, and service at the college. These courses have an added benefit of acquainting students with various aspects of their local and global environment. Geology majors leave Bowdoin equipped with tools and experiences they need for employment or graduate school as well life-long learners. To support the integration of research into our teaching we have successfully sought funding from NSF's CCLI and MRI programs. As a consequence, even first year students work with an SEM/EDAX/EBSD, with instrumented watersheds, and soon with an ocean observatory adjacent to our Coastal Studies Center, as well as taking greater advantage of local field opportunities. Our intense focus on improving curriculum and pedagogy organized and energized us within the department and helped us to present ourselves and our goals to the college.

Understanding Fear of Opportunism in Global Prize-Based Science Contests: Evidence for Gender and Age Differences

PubMed Central

Acar, Oguz Ali; van den Ende, Jan

2015-01-01

Global prize-based science contests have great potential for tapping into diverse knowledge on a global scale and overcoming important scientific challenges. A necessary step for knowledge to be utilized in these contests is for that knowledge to be disclosed. Knowledge disclosure, however, is paradoxical in nature: in order for the value of knowledge to be assessed, inventors must disclose their knowledge, but then the person who receives that knowledge does so at no cost and may use it opportunistically. This risk of potential opportunistic behavior in turn makes the inventor fearful of disclosing knowledge, and this is a major psychological barrier to knowledge disclosure. In this project, we investigated this fear of opportunism in global prize-based science contests by surveying 630 contest participants in the InnoCentive online platform for science contests. We found that participants in these science contests experience fear of opportunism to varying degrees, and that women and older participants have significantly less fear of disclosing their scientific knowledge. Our findings highlight the importance of taking differences in such fears into account when designing global prize-based contests so that the potential of the contests for reaching solutions to important and challenging problems can be used more effectively. PMID:26230086

Understanding Fear of Opportunism in Global Prize-Based Science Contests: Evidence for Gender and Age Differences.

PubMed

Acar, Oguz Ali; van den Ende, Jan

2015-01-01

Global prize-based science contests have great potential for tapping into diverse knowledge on a global scale and overcoming important scientific challenges. A necessary step for knowledge to be utilized in these contests is for that knowledge to be disclosed. Knowledge disclosure, however, is paradoxical in nature: in order for the value of knowledge to be assessed, inventors must disclose their knowledge, but then the person who receives that knowledge does so at no cost and may use it opportunistically. This risk of potential opportunistic behavior in turn makes the inventor fearful of disclosing knowledge, and this is a major psychological barrier to knowledge disclosure. In this project, we investigated this fear of opportunism in global prize-based science contests by surveying 630 contest participants in the InnoCentive online platform for science contests. We found that participants in these science contests experience fear of opportunism to varying degrees, and that women and older participants have significantly less fear of disclosing their scientific knowledge. Our findings highlight the importance of taking differences in such fears into account when designing global prize-based contests so that the potential of the contests for reaching solutions to important and challenging problems can be used more effectively.

Philosophical Aspects of Global Environmental Issues

ERIC Educational Resources Information Center

Lazutinaa, Tatyana V.; Baksheev, Vladimir N.

2016-01-01

The relevance of this paper is determined by understanding of global environmental problems in the context of social ecology. The purpose of this paper is the analysis of main modern environmental global problems created by the equipment representing a public and social basis for the practical transformation of public relations and also the…

GALAXY: A new hybrid MOEA for the optimal design of Water Distribution Systems

NASA Astrophysics Data System (ADS)

Wang, Q.; Savić, D. A.; Kapelan, Z.

2017-03-01

A new hybrid optimizer, called genetically adaptive leaping algorithm for approximation and diversity (GALAXY), is proposed for dealing with the discrete, combinatorial, multiobjective design of Water Distribution Systems (WDSs), which is NP-hard and computationally intensive. The merit of GALAXY is its ability to alleviate to a great extent the parameterization issue and the high computational overhead. It follows the generational framework of Multiobjective Evolutionary Algorithms (MOEAs) and includes six search operators and several important strategies. These operators are selected based on their leaping ability in the objective space from the global and local search perspectives. These strategies steer the optimization and balance the exploration and exploitation aspects simultaneously. A highlighted feature of GALAXY lies in the fact that it eliminates majority of parameters, thus being robust and easy-to-use. The comparative studies between GALAXY and three representative MOEAs on five benchmark WDS design problems confirm its competitiveness. GALAXY can identify better converged and distributed boundary solutions efficiently and consistently, indicating a much more balanced capability between the global and local search. Moreover, its advantages over other MOEAs become more substantial as the complexity of the design problem increases.

Lake Winnipeg Basin: Advocacy, challenges and progress for sustainable phosphorus and eutrophication control.

PubMed

Ulrich, Andrea E; Malley, Diane F; Watts, Paul D

2016-01-15

Intensification of agricultural production worldwide has altered cycles of phosphorus (P) and water. In particular, loading of P on land in fertilizer applications is a global water quality concern. The Lake Winnipeg Basin (LWB) is a major agricultural area displaying extreme eutrophication. We examined the eutrophication problem in the context of the reemerging global concern about future accessibility of phosphate rock for fertilizer production and sustainable phosphorus management. An exploratory action research participatory design was applied to study options for proactivity within the LWB. The multiple methods, including stakeholder interviews and surveys, demonstrate emerging synergies between the goals of reversing eutrophication and promoting food security. Furthermore, shifting the prevalent pollutant-driven eutrophication management paradigm in the basin toward a systemic, holistic and ecocentric approach, integrating global resource challenges, requires a mutual learning process among stakeholders in the basin to act on and adapt to ecosystem vulnerabilities. It is suggested to continue aspects of this research in a transdisciplinary format, i.e., science with society, in response to globally-expanding needs and concerns, with a possible focus on enhanced engagement of indigenous peoples and elders. Copyright © 2015 Elsevier B.V. All rights reserved.

Hepatocellular Carcinoma in Pakistan: National Trends and Global Perspective

PubMed Central

Hafeez Bhatti, Abu Bakar; Dar, Faisal Saud; Waheed, Anum; Shafique, Kashif; Sultan, Faisal; Shah, Najmul Hassan

2016-01-01

Hepatocellular carcinoma (HCC) ranks second amongst all causes of cancer deaths globally. It is on a rise in Pakistan and might represent the most common cancer in adult males. Pakistan contributes significantly to global burden of hepatitis C, which is a known risk factor for HCC, and has one of the highest prevalence rates (>3%) in the world. In the absence of a national cancer registry and screening programs, prevalence of hepatitis and HCC only represents estimates of the real magnitude of this problem. In this review, we present various aspects of HCC in Pakistan, comparing and contrasting it with the global trends in cancer care. There is a general lack of awareness regarding risk factors of HCC in Pakistani population and prevalence of hepatitis C has increased. In addition, less common risk factors are also on a rise. Majority of patients present with advanced HCC and are not eligible for definitive treatment. We have attempted to highlight issues that have a significant bearing on HCC outcome in Pakistan. A set of strategies have been put forth that can potentially help reduce incidence and improve HCC outcome on national level. PMID:26955390

Global outreach and user preferences of a smartphone application developed for drinkers.

PubMed

Zhang, Melvyn W B; Fang, Pan; Ho, Roger C M

2016-07-27

Alcohol use disorders has been known and recently highlighted by the World Health Organization as a major worldwide problem. Harmful usage of alcohol has been linked to increased morbidity and mortality arising from common alcohol related disorders, such as liver disease, hypertension and violent deaths. Looking at the current literature, there have been previous peer reviewed publications about how technology has helped alcohol users. Of significance, a previous content analysis showed that the vast majority of the applications catered for alcohol use disorder which are currently available on the stores are not only not supported by evidence-base, but some of them seemed to be promoting drinking instead. Zhang et al. have described how they have attempted to overcome the limitations of current alcohol applications in their video feature recently published. The objective of this article is to evaluate (a) the receptiveness of the general population toward an alcohol tracker application and to determine (b) user preferences with regards to the different features present in an alcohol tracker. Android Java Developmental kit (ADK) was utilized to program the core functions of the applications. The entire developmental process took approximately 6 weeks to complete and the android version of the application was launched and offered for free download on the android play store since the 4th of February 2015. The utilization of the application was then monitored and recorded using Google analytics. User perspectives with regards to the individual features of the application were collated via an application feedback survey embedded within the application. Based on the analytics, a total of 339 users have had access to the application. A cumulative total of 2029 downloads of the application have been made to date. Most of the participants are male (66%) and are of the age group of 30-39 years old (34%). The vast majority of the participants (94%) do not have any prior treatment for alcohol. Interestingly, the vast majority of the users have indicated that they have a drink 4 or more times a week (61%) and tend to drink between 3 to 4 drinks on a typical day they are out drinking. the vast majority reported that they were slightly and moderately comfortable with managing their alcohol use problem (25%). After the usage of the application, 27% of the individuals were moderately comfortable with managing their alcohol use problems and 20% of individuals were extremely comfortable with managing their alcohol use problems. In conclusion, this is perhaps one of the first few studies to demonstrate the receptiveness of an alcohol tracker that has included other behavioral change methods within as well as a variant of the conventional methodology of tracking alcohol consumption. The current study shows the receptiveness of global users as well as how such an intervention could help them gain more control about managing their underlying alcohol issue.

Method for using global optimization to the estimation of surface-consistent residual statics

DOEpatents

Reister, David B.; Barhen, Jacob; Oblow, Edward M.

2001-01-01

An efficient method for generating residual statics corrections to compensate for surface-consistent static time shifts in stacked seismic traces. The method includes a step of framing the residual static corrections as a global optimization problem in a parameter space. The method also includes decoupling the global optimization problem involving all seismic traces into several one-dimensional problems. The method further utilizes a Stochastic Pijavskij Tunneling search to eliminate regions in the parameter space where a global minimum is unlikely to exist so that the global minimum may be quickly discovered. The method finds the residual statics corrections by maximizing the total stack power. The stack power is a measure of seismic energy transferred from energy sources to receivers.

Prevalence of foot problems in people with inflammatory arthritis in Singapore.

PubMed

Carter, K; Lahiri, M; Cheung, P P; Santosa, A; Rome, K

2016-01-01

Foot problems are highly prevalent in people with inflammatory arthritis reported from studies in the UK, Europe and New Zealand, but there is limited evidence from Southeast Asia. The study aim was to evaluate the prevalence of foot problems in people with inflammatory arthritis in Singapore. People with inflammatory arthritis were recruited from the rheumatology outpatient clinic of a tertiary hospital in Singapore. Disease and clinical characteristics included age, sex, disease duration, current blood tests and medications. The Leeds Foot Impact Scale was used to evaluate foot impairment/disability and the Modified Health Assessment Questionnaire was used to assess global function. We recruited 101 people with inflammatory arthritis, of which 50 % were female. The majority of participants were Chinese (70 %). The mean (SD) age was 52 (15) years, and the mean (SD) disease duration was 9.3 (0.3) years. The most commonly reported inflammatory arthritic conditions were rheumatoid arthritis (46), gout (31) and spondyloarthritis (15 %). The mean (SD) of the total Leeds Foot Impact Scale was 17 (13) indicating moderate to severe levels of foot impairment and activity limitation. Over 80 of participants reported foot pain during the course of their condition, and 48 % reported current foot pain. Despite the high prevalence of foot pain, only 21 participants (21 %) had been referred to a podiatrist. This is the first study to investigate the prevalence of foot problems in people with inflammatory arthritis from Singapore. The majority of the participants reported foot problems, but had not been referred to a podiatry service.

Evaluation of fluoride levels in bottled water and their contribution to health and teeth problems in the United Arab Emirates.

PubMed

Abouleish, Mohamed Yehia Z

2016-10-01

Fluoride is needed for better health, yet if ingested at higher levels it may lead to health problems. Fluoride can be obtained from different sources, with drinking water being a major contributor. In the United Arab Emirates (UAE), bottled water is the major source for drinking. The aim of this research is to measure fluoride levels in different bottled water brands sold in UAE, to determine whether fluoride contributes to better health or health problems. The results were compared to international and local standards. Fluoride was present in seven out of 23 brands. One brand exhibited high fluoride levels, which exceeded all standards, suggesting it may pose health problems. Other brands were either below or above standards, suggesting either contribution to better health or health problems, depending on ingested amount. A risk assessment suggested a potential for non-cancer effects from some brands. The results were compared to fluoride levels in bottled water sold in UAE and neighboring countries (e.g. Saudi Arabia, Qatar, Kuwait, and Bahrain), over 24 years, to reflect on changes in fluoride levels in bottled water in this region. The research presents the need for creating, stricter regulations that require careful fluoride monitoring and new regulations that require listing fluoride level on the bottled water label, internationally and regionally. The research will have local and global health impact, as bottled water sold in UAE and neighboring countries, is produced locally and imported from international countries, e.g. Switzerland, the USA, France, Italy, New Zealand, and Fiji.

Vertical Scan (V-SCAN) for 3-D Grid Adaptive Mesh Refinement for an atmospheric Model Dynamical Core

NASA Astrophysics Data System (ADS)

Andronova, N. G.; Vandenberg, D.; Oehmke, R.; Stout, Q. F.; Penner, J. E.

2009-12-01

One of the major building blocks of a rigorous representation of cloud evolution in global atmospheric models is a parallel adaptive grid MPI-based communication library (an Adaptive Blocks for Locally Cartesian Topologies library -- ABLCarT), which manages the block-structured data layout, handles ghost cell updates among neighboring blocks and splits a block as refinements occur. The library has several modules that provide a layer of abstraction for adaptive refinement: blocks, which contain individual cells of user data; shells - the global geometry for the problem, including a sphere, reduced sphere, and now a 3D sphere; a load balancer for placement of blocks onto processors; and a communication support layer which encapsulates all data movement. A major performance concern with adaptive mesh refinement is how to represent calculations that have need to be sequenced in a particular order in a direction, such as calculating integrals along a specific path (e.g. atmospheric pressure or geopotential in the vertical dimension). This concern is compounded if the blocks have varying levels of refinement, or are scattered across different processors, as can be the case in parallel computing. In this paper we describe an implementation in ABLCarT of a vertical scan operation, which allows computing along vertical paths in the correct order across blocks transparent to their resolution and processor location. We test this functionality on a 2D and a 3D advection problem, which tests the performance of the model’s dynamics (transport) and physics (sources and sinks) for different model resolutions needed for inclusion of cloud formation.

Water and Social Justice in Bangladesh: A Transdisciplinary and Intercultural Approach

NASA Astrophysics Data System (ADS)

Gilligan, J. M.; Ackerly, B.; Ahmed, K.; Benneyworth, L.; Goodbred, S. L.; Hall, M.; Jacobi, J. H.; Mondal, D. R.; Pickering, J.; Rogers, K. G.; Roy, K.; Wallace Auerbach, L.

2013-12-01

Effectively addressing environmental problems---at local, national, and global scales---requires actively crossing disciplinary boundaries between natural sciences, engineering, social sciences, and policymaking. The best technical solution is useless if it cannot win political support from the people it is intended to help. Enacted policies are too often hindered either by misunderstanding or ignorance of scientific and technical aspects of the problem or by misunderstanding the behavior of the population they address. Environmental problems at the international scale also require understanding of cultural and social differences across national boundaries. To prepare graduate students to be professionally effective at addressing major environmental problems, Vanderbilt University has created a transdisciplinary, intercultural course that brings students from the US and Bangladesh together, both through online connections such as blogs and Skype sessions, and in person in a week-long joint field trip in which students and faculty from universities in both countries, and representing many disciplines work side-by-side to study water as both a natural resource and a natural hazard. Activities included studying sources of drinking water, observing areas affected by flooding from cyclone storm surges, cataloging physical infrastructure, and conducting interviews with residents of vulnerable areas. Few if any students can simultaneously master the social sciences, natural sciences, and engineering skills necessary to comprehensively address major environmental problems, but students can learn to work and communicate effectively with peers in other disciplines, working together to understand the complex interactions between different aspects of their problem. We will report on the structure of the course; our experiences as faculty and student participants; and connections between this class, graduate curricula in environmental sciences, and international transdisciplinary research projects.

The Mountain Invasion Research Network (MIREN): Linking Local and Global Scales for Addressing an Ecological Consequence of Global Change

Treesearch

Christoph Kueffer; Curtis Daehler; Hansjörg Dietz; Keith McDougall; Catherine Parks; Aníbal Pauchard; Lisa Rew

2014-01-01

Many modern environmental problems span vastly different spatial scales, from the management of local ecosystems to understanding globally interconnected processes, and addressing them through international policy. MIREN tackles one such “glocal” (global/local) environmental problem – plant invasions in mountains – through a transdisciplinary, multi-scale learning...

Crossing Borders: A Qualitative Study of How Occupational Therapy Educators and Scholars Develop and Sustain Global Partnerships.

PubMed

Witchger Hansen, Anne Marie

2015-09-01

The World Federation of Occupational Therapists (WFOT) and the American Occupational Therapy Association promote a globally connected profession that responds to the needs of our diverse societies. Global partnerships are grounded on the principle that cross-cultural experiences are enriching and provide mutual benefits. The purpose of this study was to uncover how occupational therapy educators and scholars perceive and experience (1) developing and sustaining global partnerships and (2) lessons learned. In this qualitative study, 30 occupational therapy educators and researchers completed an online survey. Eight participated in an interview. Results found major themes that help develop and sustain partnerships: building relationship of trust and respect, communicating effectively, cultivating cultural competence, sharing power and resources with collaborators and creating a context for reciprocal learning. Lessons learned include a call to walking humbly, building relationships of trust and respect, establishing open and honest communication, supporting local solutions to local problems, ensuring equality of resources and learning from their global partners. The findings suggest that global partnerships have the potential to transform both partners if the partners engage with mutual understanding and respect. Limitations of this study include a small sample size and participant's pool limited to occupational therapists from United States. Recommendations for future research include qualitative studies to identify model occupational therapy programmes that sustain global partnerships using a diverse sample of international occupational therapy educators and researchers. © 2015 John Wiley & Sons, Ltd.

Addressing Society's Problems in a Global Studies Class.

ERIC Educational Resources Information Center

Pesce, Louis; And Others

1996-01-01

Describes the adaptation of the Future Problem-Solving Process (FPS) in a global studies class. The process applies state-of-the-art critical thinking and problem solving to unstable areas such as the Middle East and the former Soviet Union. Includes handouts directing the students through the process. (MJP)

The Globalization of Higher Education as a Societal and Cultural Security Problem

ERIC Educational Resources Information Center

Samier, Eugenie A.

2015-01-01

In this article, I propose a theory of the globalization of higher education as societal and cultural security problems for many regions of the world. The first section examines the field of security studies for theoretical frameworks appropriate to critiquing globalized higher education, including critical human, societal and cultural security…

Lessons from Abroad: Teaching Cultural and Global Leadership in the U.S. Classroom

ERIC Educational Resources Information Center

Zimmerman, Jeff

2015-01-01

This paper provides an insightful perspective to the common problem facing many global leadership educators across the U.S.: helping students understand "global leadership" while they sit in U.S. classrooms. The instructor of an undergraduate leadership course addressed this problem by recreating for U.S. students in local "cultural…

Multiple Approaches for Testing Novel Coatings in the Laboratory and in Pearl Harbor, Hawaii with Emphasis on the Global, Problem-Fouling Invertebrates

DTIC Science & Technology

2015-09-25

Multiple Approaches for Testing Novel Coatings in the Laboratory and in Pearl Harbor, Hawaii with Emphasis on the Global, Problem-Fouling Invertebrates 5a...on the Global, Problem-Fouling Invertebrates ONR AWARD NUMBER: N00014-11-1-0167 PRINCIPLE INVESTIGATOR: Michael G. Hadfield, Ph.D...luteoviolacea a phage tail-like component that is capable of inducing the metamorphosis of a marine invertebrate . However, our continued studies in the

A comparative review of environmental concern prioritization: LEED vs other major certification systems.

PubMed

Suzer, Ozge

2015-05-01

The matter of environmental concern prioritization integrated into globally used green building rating systems is a fundamental issue since it determines how the performance of a structure or development is reflected. Certain nationally-developed certification systems are used globally without being subjected to adjustments with respect to local geographical, cultural, economic and social parameters. This may lead to a situation where the results of an evaluation may not reflect the reality of the region and/or the site of construction. The main objective of this paper is to examine and underline the problems regarding the issue of weighting environmental concerns in the Leadership in Energy and Environmental Design (LEED) certification system, which is a US-originated but globally used assessment tool. The methodology of this study consists of; (i) an analysis of the approach of LEED in the New Construction and Major Renovations scheme in version 3 (LEED NC, v.3) and the Building Design and Construction scheme in version 4 (LEED BD + C, v.4), (ii) case studies in which regional priority credits (RPCs) set by LEED for four countries (Canada, Turkey, China and Egypt) are criticized with respect to countries' own local conditions, and, (iii) an analysis of the approaches of major environmental assessment tools, namely; BREEAM, SBTool, CASBEE and Green Star, in comparison to the approach in LEED, regarding the main issue of this paper. This work shows that, even in its latest version (v.4) LEED still displays some inadequacies and inconsistencies from the aspect of environmental concern prioritization and has not yet managed to incorporate a system which is more sensitive to this issue. This paper further outlines the differences and similarities between the approaches of the aforementioned major environmental assessment tools with respect to the issue of concern and the factors that should be integrated into future versions of LEED. Copyright © 2015 Elsevier Ltd. All rights reserved.

Diesel engine performance and emissions with fuels derived from waste tyres.

PubMed

Verma, Puneet; Zare, Ali; Jafari, Mohammad; Bodisco, Timothy A; Rainey, Thomas; Ristovski, Zoran D; Brown, Richard J

2018-02-06

The disposal of waste rubber and scrap tyres is a significant issue globally; disposal into stockpiles and landfill poses a serious threat to the environment, in addition to creating ecological problems. Fuel production from tyre waste could form part of the solution to this global issue. Therefore, this paper studies the potential of fuels derived from waste tyres as alternatives to diesel. Production methods and the influence of reactor operating parameters (such as reactor temperature and catalyst type) on oil yield are outlined. These have a major effect on the performance and emission characteristics of diesel engines when using tyre derived fuels. In general, tyre derived fuels increase the brake specific fuel consumption and decrease the brake thermal efficiency. The majority of studies indicate that NOx emissions increase with waste tyre derived fuels; however, a few studies have reported the opposite trend. A similar increasing trend has been observed for CO and CO 2 emissions. Although most studies reported an increase in HC emission owing to lower cetane number and higher density, some studies have reported reduced HC emissions. It has been found that the higher aromatic content in such fuels can lead to increased particulate matter emissions.

Environmental Lessons from China: Finding Promising Policies 
in Unlikely Places

PubMed Central

Zhang, Junfeng

2011-01-01

Background: Alongside the major health risks posed by environmental pollution in China are recent achievements on several environmental issues that have affluent Western nations racing to catch up. The country has propelled itself to a position of leadership in clean energy and efficiency, for instance, with important consequences for public health. Objectives: We comment on China’s challenges and recent accomplishments in addressing environmental problems from domestic pollution to global climate change. We compare China’s commitment to clean energy technology with that of other leading nations and discuss key achievements in other areas, including vehicle efficiency standards and transportation policy. Discussion: We discuss policy directions that would secure much-needed improvements to environmental quality and health in China, along with actions that could motivate global action on issues of energy conservation and pollution reduction. Conclusions: A comprehensive regulatory and institutional framework for environmental policy is within reach in China but will require addressing major hurdles such as the lack of an independent monitoring mechanism and the need for greater transparency and enforcement in environmental matters. Meanwhile, China can continue to set important examples by investing in renewable energy, improving energy efficiency, and limiting greenhouse gas emissions. PMID:21402514

Vitamin Deficiencies in Humans: Can Plant Science Help?[W

PubMed Central

Fitzpatrick, Teresa B.; Basset, Gilles J.C.; Borel, Patrick; Carrari, Fernando; DellaPenna, Dean; Fraser, Paul D.; Hellmann, Hanjo; Osorio, Sonia; Rothan, Christophe; Valpuesta, Victoriano; Caris-Veyrat, Catherine; Fernie, Alisdair R.

2012-01-01

The term vitamin describes a small group of organic compounds that are absolutely required in the human diet. Although for the most part, dependency criteria are met in developed countries through balanced diets, this is not the case for the five billion people in developing countries who depend predominantly on a single staple crop for survival. Thus, providing a more balanced vitamin intake from high-quality food remains one of the grandest challenges for global human nutrition in the coming decade(s). Here, we describe the known importance of vitamins in human health and current knowledge on their metabolism in plants. Deficits in developing countries are a combined consequence of a paucity of specific vitamins in major food staple crops, losses during crop processing, and/or overreliance on a single species as a primary food source. We discuss the role that plant science can play in addressing this problem and review successful engineering of vitamin pathways. We conclude that while considerable advances have been made in understanding vitamin metabolic pathways in plants, more cross-disciplinary approaches must be adopted to provide adequate levels of all vitamins in the major staple crops to eradicate vitamin deficiencies from the global population. PMID:22374394

Global Human Trafficking and Child Victimization.

PubMed

Greenbaum, Jordan; Bodrick, Nia

2017-12-01

Trafficking of children for labor and sexual exploitation violates basic human rights and constitutes a major global public health problem. Pediatricians and other health care professionals may encounter victims who present with infections, injuries, posttraumatic stress disorder, suicidality, or a variety of other physical or behavioral health conditions. Preventing child trafficking, recognizing victimization, and intervening appropriately require a public health approach that incorporates rigorous research on the risk factors, health impact, and effective treatment options for child exploitation as well as implementation and evaluation of primary prevention programs. Health care professionals need training to recognize possible signs of exploitation and to intervene appropriately. They need to adopt a multidisciplinary, outward-focused approach to service provision, working with nonmedical professionals in the community to assist victims. Pediatricians also need to advocate for legislation and policies that promote child rights and victim services as well as those that address the social determinants of health, which influence the vulnerability to human trafficking. This policy statement outlines major issues regarding public policy, medical education, research, and collaboration in the area of child labor and sex trafficking and provides recommendations for future work. Copyright © 2017 by the American Academy of Pediatrics.

Vaccines and future global health needs

PubMed Central

Nossal, G. J. V.

2011-01-01

Increased international support for both research into new vaccines and their deployment in developing countries has been evident over the past decade. In particular, the GAVI Alliance has had a major impact in increasing uptake of the six common infant vaccines as well as those against hepatitis B and yellow fever. It further aims to introduce pneumococcal and rotavirus vaccines in the near future and several others, including those against human papillomavirus, meningococcal disease, rubella and typhoid not long after that. In addition, there is advanced research into vaccines against malaria, HIV/AIDS and tuberculosis. By 2030, we may have about 20 vaccines that need to be used in the developing world. Finding the requisite funds to achieve this will pose a major problem. A second and urgent question is how to complete the job of global polio eradication. The new strategic plan calls for completion by 2013, but both pre-eradication and post-eradication challenges remain. Vaccines will eventually become available beyond the field of infectious diseases. Much interesting work is being done in both autoimmunity and cancer. Cutting across disease groupings, there are issues in methods of delivery and new adjuvant formulations. PMID:21893548

Inadvertent Weather Modification in Urban Areas: Lessons for Global Climate Change.

NASA Astrophysics Data System (ADS)

Changnon, Stanley A.

1992-05-01

Large metropolitan areas in North America, home to 65% of the nation's population, have created major changes in their climates over the past 150 years. The rate and amount of the urban climate change approximate those being predicted globally using climate models. Knowledge of urban weather and climate modification holds lessons for the global climate change issue. First, adjustments to urban climate changes can provide guidance for adjusting to global change. A second lesson relates to the difficulty but underscores the necessity of providing scientifically credible proof of change within the noise of natural climatic variability. The evolution of understanding about how urban conditions influence weather reveals several unexpected outcomes, particularly relating to precipitation changes. These suggest that similar future surprises can be expected in a changed global climate, a third lesson. In-depth studies of how urban climate changes affected the hydrologic cycle, the regional economy, and human activities were difficult because of data problems, lack of impact methodology, and necessity for multi disciplinary investigations. Similar impact studies for global climate change will require diverse scientific talents and funding commitments adequate to measure the complexity of impacts and human adjustments. Understanding the processes whereby urban areas and other human activities have altered the atmosphere and changed clouds and precipitation regionally appears highly relevant to the global climate-change issue. Scientific and governmental policy development needs to recognize an old axiom that became evident in the studies of inadvertent urban and regional climate change and their behavioral implications: Think globally but act locally. Global climate change is an international issue, and the atmosphere must be treated globally. But the impacts and the will to act and adjust will occur regionally.

Global Dissemination of blaKPC into Bacterial Species beyond Klebsiella pneumoniae and In Vitro Susceptibility to Ceftazidime-Avibactam and Aztreonam-Avibactam.

PubMed

Kazmierczak, Krystyna M; Biedenbach, Douglas J; Hackel, Meredith; Rabine, Sharon; de Jonge, Boudewijn L M; Bouchillon, Samuel K; Sahm, Daniel F; Bradford, Patricia A

2016-08-01

The Klebsiella pneumoniae carbapenemase (KPC), first described in the United States in 1996, is now a widespread global problem in several Gram-negative species. A worldwide surveillance study collected Gram-negative pathogens from 202 global sites in 40 countries during 2012 to 2014 and determined susceptibility to β-lactams and other class agents by broth microdilution testing. Molecular mechanisms of β-lactam resistance among carbapenem-nonsusceptible Enterobacteriaceae and Pseudomonas aeruginosa were determined using PCR and sequencing. Genes encoding KPC enzymes were found in 586 isolates from 22 countries (76 medical centers), including countries in the Asia-Pacific region (32 isolates), Europe (264 isolates), Latin America (210 isolates), and the Middle East (19 isolates, Israel only) and the United States (61 isolates). The majority of isolates were K. pneumoniae (83.4%); however, KPC was detected in 13 additional species. KPC-2 (69.6%) was more common than KPC-3 (29.5%), with regional variation observed. A novel KPC variant, KPC-18 (KPC-3[V8I]), was identified during the study. Few antimicrobial agents tested remained effective in vitro against KPC-producing isolates, with ceftazidime-avibactam (MIC90, 4 μg/ml), aztreonam-avibactam (MIC90, 0.5 μg/ml), and tigecycline (MIC90, 2 μg/ml) retaining the greatest activity against Enterobacteriaceae cocarrying KPC and other β-lactamases, whereas colistin (MIC90, 2 μg/ml) demonstrated the greatest in vitro activity against KPC-positive P. aeruginosa This analysis of surveillance data demonstrated that KPC is widely disseminated. KPC was found in multiple species of Enterobacteriaceae and P. aeruginosa and has now become a global problem. Copyright © 2016, American Society for Microbiology. All Rights Reserved.

The World Oral Health Report 2003: continuous improvement of oral health in the 21st century--the approach of the WHO Global Oral Health Programme.

PubMed

Petersen, Poul Erik

2003-12-01

Chronic diseases and injuries are the leading health problems in all but a few parts of the world. The rapidly changing disease patterns throughout the world are closely linked to changing lifestyles, which include diets rich in sugars, widespread use of tobacco, and increased consumption of alcohol. In addition to socio-environmental determinants, oral disease is highly related to these lifestyle factors, which are risks to most chronic diseases as well as protective factors such as appropriate exposure to fluoride and good oral hygiene. Oral diseases qualify as major public health problems owing to their high prevalence and incidence in all regions of the world, and as for all diseases, the greatest burden of oral diseases is on disadvantaged and socially marginalized populations. The severe impact in terms of pain and suffering, impairment of function and effect on quality of life must also be considered. Traditional treatment of oral diseases is extremely costly in several industrialized countries, and not feasible in most low-income and middle-income countries. The WHO Global Strategy for Prevention and Control of Noncommunicable Diseases, added to the common risk factor approach is a new strategy for managing prevention and control of oral diseases. The WHO Oral Health Programme has also strengthened its work for improved oral health globally through links with other technical programmes within the Department for Noncommunicable Disease Prevention and Health Promotion. The current oral health situation and development trends at global level are described and WHO strategies and approaches for better oral health in the 21st century are outlined.

Knowledge-based design of generate-and-patch problem solvers that solve global resource assignment problems

NASA Technical Reports Server (NTRS)

Voigt, Kerstin

1992-01-01

We present MENDER, a knowledge based system that implements software design techniques that are specialized to automatically compile generate-and-patch problem solvers that satisfy global resource assignments problems. We provide empirical evidence of the superior performance of generate-and-patch over generate-and-test: even with constrained generation, for a global constraint in the domain of '2D-floorplanning'. For a second constraint in '2D-floorplanning' we show that even when it is possible to incorporate the constraint into a constrained generator, a generate-and-patch problem solver may satisfy the constraint more rapidly. We also briefly summarize how an extended version of our system applies to a constraint in the domain of 'multiprocessor scheduling'.

Climate change impacts on water availability: developing regional scenarios for agriculture of the Former Soviet Union countries of Central Asia

NASA Astrophysics Data System (ADS)

Kirilenko, A.; Dronin, N.

2010-12-01

Water is the major factor, limiting agriculture of the five Former Soviet Union (FSU) of Central Asia. Elevated topography prevents moist and warm air from the Atlantic and Indian Oceans from entering the region.With exception of Kazakhstan, agriculture is generally restricted to oases and irrigated lands along the major rivers and canals. Availability of water for irrigation is the major factor constraining agriculture in the region, and conflicts over water are not infrequent. The current water crisis in the region is largely due to human activity; however the region is also strongly impacted by the climate. In multiple locations, planned and autonomous adaptations to climate change have already resulted in changes in agriculture, such as a dramatic increase in irrigation, or shift in crops towards the ones better suited for warmer and dryer climate; however, it is hard to differentiate between the effects of overall management improvement and the avoidance of climate-related losses. Climate change will contribute to water problems, escalating irrigation demand during the drought period, and increasing water loss with evaporation. The future of the countries of the Aral Sea basin then depends on both the regional scenario of water management policy and a global scenario of climate change, and is integrated with global socioeconomic scenarios. We formulate a set of regional policy scenarios (“Business as Usual”, “Falling Behind” and “Closing the Gap”) and demonstrate how each of them corresponds to IPCC SRES scenarios, the latter used as an input to the General Circulation Models (GCMs). Then we discuss the relative effectiveness of the introduced scenarios for mitigating water problems in the region, taking into account the adaptation through changing water demand for agriculture. Finally, we introduce the results of multimodel analysis of GCM climate projections, especially in relation to the change in precipitation and frequency of droughts, and discuss the impact of climate change on future development of the region.

Medicalization of global health 3: the medicalization of the non-communicable diseases agenda.

PubMed

Clark, Jocalyn

2014-01-01

There is growing recognition of the massive global burden of non-communicable diseases (NCDs) due to their prevalence, projected social and economic costs, and traditional neglect compared to infectious disease. The 2011 UN Summit, WHO 25×25 targets, and support of major medical and advocacy organisations have propelled prominence of NCDs on the global health agenda. NCDs are by definition 'diseases' so already medicalized. But their social drivers and impacts are acknowledged, which demand a broad, whole-of-society approach. However, while both individual- and population-level targets are identified in the current NCD action plans, most recommended strategies tend towards the individualistic approach and do not address root causes of the NCD problem. These so-called population strategies risk being reduced to expectations of individual and behavioural change, which may have limited success and impact and deflect attention away from government policies or regulation of industry. Industry involvement in NCD agenda-setting props up a medicalized approach to NCDs: food and drink companies favour focus on individual choice and responsibility, and pharmaceutical and device companies favour calls for expanded access to medicines and treatment coverage. Current NCD framing creates expanded roles for physicians, healthcare workers, medicines and medical monitoring. The professional rather than the patient view dominates the NCD agenda and there is a lack of a broad, engaged, and independent NGO community. The challenge and opportunity lie in defining priorities and developing strategies that go beyond a narrow medicalized framing of the NCD problem and its solutions.

An Assessment of the Scientific Basis Behind Global Environmental Concerns in the 21st Century

NASA Technical Reports Server (NTRS)

Singh, Hanwant B.; Hipskind, R. Stephen (Technical Monitor)

2001-01-01

The notion that human activities may endanger the earth's environment has emerged as a leading societal concern in the post industrial era. Under the ever increasing pressures of population growth and industrialization, the problems of local air pollution have now become matters of both local and global concern. Smog, toxic chemicals, acid rain, ozone depletion, and climate change have become household words and an intense public policy debate about the cost and benefits of environmental protection continues. There is a growing realization that the consequences of air pollution can be felt in unpredictable ways in near and far away places. Unpopulated regions of the world such as the arctic now suffer from arctic haze and ozone depletions are the largest in the Antarctic stratosphere. In the last4ol three decades many countries have instituted ambient air quality standards designed to mitigate problems of health and welfare associated with the release of chemicals. Global agreements to prevent the depletion of ozone layer and to slow down climatic warming are being actively debated and formulated. In parallel there has been an intense exploration of the science of air pollution all over the world. The scientific basis behind environmental concerns is imperfect and is central to this debate. I will review our current scientific understanding of some of the major environmental concerns. An assessment of the forthcoming efforts to put this science on a more solid footing will be provided.

The Solutions Project: Educating the Public and Policy Makers About Solutions to Global Warming, Air Pollution, and Energy Security

NASA Astrophysics Data System (ADS)

Jacobson, M. Z.

2015-12-01

Three major global problems of our times are global warming, air pollution mortality and morbidity, and energy insecurity. Whereas, policy makers with the support of the public must implement solutions to these problems, it is scientists and engineers who are best equipped to evaluate technically sound, optimal, and efficient solutions. Yet, a disconnect exists between information provided by scientists and engineers and policies implemented. Part of the reason is that scientific information provided to policy makers and the public is swamped out by information provided by lobbyists and another part is the difficulty in providing information to the hundreds of millions of people who need it rather than to just a few thousand. What other ways are available, aside from issuing press releases on scientific papers, for scientists to disseminate information? Three growing methods are through social media, creative media, and storytelling. The Solutions Project is a non-profit non-governmental organization whose goal is to bring forth scientific information about 100% clean, renewable energy plans to the public, businesses, and policy makers using these and related tools. Through the use of social media, the development of engaging internet and video content, and storytelling, the group hopes to increase the dissemination of information for social good. This talk discusses the history and impacts to date of this group and its methods. Please see www.thesolutionsproject.org and 100.org for more information.

Knowledge and beliefs on antimicrobial resistance among physicians and nurses in hospitals in Amhara Region, Ethiopia.

PubMed

Abera, Bayeh; Kibret, Mulugeta; Mulu, Wondemagegn

2014-05-19

Antimicrobial resistance (AMR) is a major global public health problem both in hospital and community acquired infections. The present study assessed the knowledge and beliefs on AMR among physicians and nurses in 13 hospitals in Amhara region, Ethiopia, which is a low-income country. A cross-sectional study using a self-administered questionnaire was applied. A total of 385 participants (175 physicians and 210 nurses) took part in the study. Sixty five percent of physicians and 98% of nurses replied that they need training on antimicrobial stewardship. Only 48% of physicians and 22.8% of nurses had exposures for local antibiogram data. Overall, 278 (72.2%) of participants were knowledgeable about AMR. Majority of participants agreed or strongly agreed AMR as worldwide and national problem but few considered AMR as problem in their own hospitals. The two most important factors mentioned for AMR development were patients' poor adherence to prescribed antimicrobials (86%) and overuse of antibiotics (80.5%). The most leading local factors identified for AMR development were: self-antibiotic prescription (53.5%), lack of access to local antibiogram data (12.3%) and prescriber poor awareness about AMR (9.2%). Factors perceived for excessive antibiotic prescriptions were: patient drive (56%), treatment failure (79%), unknown febrile illnesses (39.7%) and upper respiratory tract infections (33.4%). Majority of physicians and nurses lack up to-date knowledge on AMR. Unavailability of local antibiogram data, self-prescription by patients and poor awareness on AMR are areas of interventions for prevention and control of AMR.

Burden of non-hip, non-vertebral fractures on quality of life in postmenopausal women: the Global Longitudinal study of Osteoporosis in Women (GLOW)

PubMed Central

Roux, C.; Wyman, A.; Hooven, F. H.; Gehlbach, S. H.; Adachi, J. D.; Chapurlat, R. D.; Compston, J. E.; Cooper, C.; Díez-Pérez, A.; Greenspan, S. L.; LaCroix, A. Z.; Netelenbos, J. C.; Pfeilschifter, J.; Rossini, M.; Saag, K. G.; Sambrook, P. N.; Silverman, S.; Siris, E. S.; Watts, N. B.; Boonen, S.

2016-01-01

Purpose Most fracture studies have focused on hip and vertebral fractures, but there is growing evidence that non-hip, non-vertebral (NHNV) fractures also result in substantial morbidity and healthcare costs. We sought to assess the effect of NHNV fractures on quality of life. Methods We analyzed 1-year incidences of hip, spine, major NHNV (pelvis/leg, shoulder/arm) and minor NHNV (wrist/hand, ankle/foot, rib/clavicle) fractures among women from the GLOW registry, a prospective, multinational, observational cohort study. Health-related quality of life (HRQL) was analyzed using EuroQol EQ-5D and the SF-36 health survey. Results Among 50,461 women analyzed, there were 1,822 fractures (57% minor NHNV, 26% major NHNV, 10% spine, 7% hip) over 1 year. Spine fractures had the greatest detrimental effect on EQ-5D summary scores, followed by major NHNV and hip fractures. The amount of women with mobility problems increased most for those with major NHNV and spine fractures (both +8%); spine fractures were associated with the largest increases in problems with self care (+11%), activities (+14%), and pain/discomfort (+12%). Decreases in physical function and health status were greatest for women with spine or hip fractures. Multivariable modeling found that EQ-5D reduction was greatest for spine fractures, followed by hip and major/minor NHNV. Significant reductions in SF-36 physical function were found only for spine and major NHNV fractures. Conclusion This prospective study shows that NHNV fractures have a detrimental effect on HRQL. As NHNV fractures account for >80% of incident fractures, efforts to optimize osteoporosis care should include prevention of NHNV fractures. PMID:22398855

Earth System Science Education Modules

NASA Astrophysics Data System (ADS)

Hall, C.; Kaufman, C.; Humphreys, R. R.; Colgan, M. W.

2009-12-01

The College of Charleston is developing several new geoscience-based education modules for integration into the Earth System Science Education Alliance (ESSEA). These three new modules provide opportunities for science and pre-service education students to participate in inquiry-based, data-driven experiences. The three new modules will be discussed in this session. Coastal Crisis is a module that analyzes rapidly changing coastlines and uses technology - remotely sensed data and geographic information systems (GIS) to delineate, understand and monitor changes in coastal environments. The beaches near Charleston, SC are undergoing erosion and therefore are used as examples of rapidly changing coastlines. Students will use real data from NASA, NOAA and other federal agencies in the classroom to study coastal change. Through this case study, learners will acquire remotely sensed images and GIS data sets from online sources, utilize those data sets within Google Earth or other visualization programs, and understand what the data is telling them. Analyzing the data will allow learners to contemplate and make predictions on the impact associated with changing environmental conditions, within the context of a coastal setting. To Drill or Not To Drill is a multidisciplinary problem based module to increase students’ knowledge of problems associated with nonrenewable resource extraction. The controversial topic of drilling in the Arctic National Wildlife Refuge (ANWR) examines whether the economic benefit of the oil extracted from ANWR is worth the social cost of the environmental damage that such extraction may inflict. By attempting to answer this question, learners must balance the interests of preservation with the economic need for oil. The learners are exposed to the difficulties associated with a real world problem that requires trade-off between environmental trust and economic well-being. The Citizen Science module challenges students to translate scientific information into words that are understandable and useful for policy makers and other stakeholders. The inability of scientists to effectively communicate with the public has been highlighted as a major reason for the anti-science attitude of a large segment of the public. This module, unlike other ESSEA modules, addresses this problem by first, investigating a global change environmental problem using Earth System Science methodologies, then developing several solutions to that problem, and finally writing a position paper for the policy makers to use. These three hands-on, real-world modules that engage students in authentic research share similar goals: 1) to use global change data sets to examine controversial environmental problems; 2) to use an earth system science approach to understand the complexity of global problems; and 3) to help students understand the political complexity of environmental problems where there is a clash between economic and ecological problems. The curriculum will meet National Standards in science, geography, math, etc.

Fluid mechanics in crystal growth - The 1982 Freeman scholar lecture

NASA Technical Reports Server (NTRS)

Ostrach, S.

1983-01-01

An attempt is made to unify the current state of knowledge in crystal growth techniques and fluid mechanics. After identifying important fluid dynamic problems for such representative crystal growth processes as closed tube vapor transport, open reactor vapor deposition, and the Czochralski and floating zone melt growth techniques, research results obtained to date are presented. It is noted that the major effort to date has been directed to the description of the nature and extent of bulk transport under realistic conditions, where bulk flow determines the heat and solute transport which strongly influence the temperature and concentration fields in the vicinity of the growth interface. Proper treatment of near field, or interface, problems cannot be given until the far field, or global flow, involved in a given crystal growth technique has been adequately described.

Ethical Issues in Tuberculosis Control

PubMed Central

Elbek, Osman

2015-01-01

Tuberculosis (TB) remains a major global public health problem as also defined by the World Health Organization (WHO). On the other hand, the incidence of TB worldwide decreases at a lower rate than the intended targets, and it is seen that the targets set for 2015 will not be achieved at the global level. According to the WHO, failure to achieve the targets in TB control results from “resource constraints”, “conflict and instability” and “generalized human immunodeficiency virus epidemics”. This article is aimed to maintain an ethical debate in TB control and to investigate the WHO’s TB control policy and question the reasons for failure of this policy. Within the scope of this article; the TB of TB control was problematized at macro political level within the context of philosophy, while the approach of health care staff to TB patients was analysed at micro level within the context of professional ethics. PMID:29404082

Lithospheric dynamics near plate boundaries

NASA Technical Reports Server (NTRS)

Solomon, Sean C.

1992-01-01

The progress report on research conducted between 15 Mar. - 14 Sep. 1992 is presented. The focus of the research during the first grant year has been on several problems broadly related to the nature and dynamics of time-dependent deformation and stress along major seismic zones, with an emphasis on western North America but with additional work on seismic zones in oceanic lithosphere as well. The principal findings of our research to date are described in the accompanying papers and abstract. Topics covered include: (1) Global Positioning System measurements of deformations associated with the 1987 Superstition Hills earthquake: evidence for conjugate faulting; (2) Global Positioning System measurements of strain accumulation across the Imperial Valley, California: 1986-1989; (3) present-day crustal deformation in the Salton Trough, southern California; (4) oceanic transform earthquakes with unusual mechanisms or locations: relation to fault geometry and state of stress in the lithosphere; and (5) crustal strain and the 1992 Mojave Desert earthquakes.

The role of extreme orbits in the global organization of periodic regions in parameter space for one dimensional maps

NASA Astrophysics Data System (ADS)

da Costa, Diogo Ricardo; Hansen, Matheus; Guarise, Gustavo; Medrano-T, Rene O.; Leonel, Edson D.

2016-04-01

We show that extreme orbits, trajectories that connect local maximum and minimum values of one dimensional maps, play a major role in the parameter space of dissipative systems dictating the organization for the windows of periodicity, hence producing sets of shrimp-like structures. Here we solve three fundamental problems regarding the distribution of these sets and give: (i) their precise localization in the parameter space, even for sets of very high periods; (ii) their local and global distributions along cascades; and (iii) the association of these cascades to complicate sets of periodicity. The extreme orbits are proved to be a powerful indicator to investigate the organization of windows of periodicity in parameter planes. As applications of the theory, we obtain some results for the circle map and perturbed logistic map. The formalism presented here can be extended to many other different nonlinear and dissipative systems.

The Diabetic foot: A global threat and a huge challenge for Greece

PubMed Central

Papanas, N; Maltezos, E

2009-01-01

The diabetic foot continues to be a major cause of morbidity, posing a global threat. Substantial progress has been now accomplished in the treatment of foot lesions, but further improvement is required. Treatment options may be classified into established measures (revascularisation, casting and debridement) and new modalities. All therapeutic measures should be provided by specialised dedicated multidisciplinary foot clinics. In particular, the diabetic foot is a huge challenge for Greece. There is a dramatic need to increase the number of engaged foot care teams and their resources throughout the country. It is also desirable to continue education of both physicians and general diabetic population on the magnitude of the problem and on the suitable preventative measures. At the same time, more data on the prevalence and clinical manifestations of the diabetic foot in Greece should be carefully collected. Finally, additional research should investigate feasible ways of implementing current knowledge in everyday clinical practice. PMID:20011082

Global Climate Change and Children's Health.

PubMed

Ahdoot, Samantha; Pacheco, Susan E

2015-11-01

Rising global temperature is causing major physical, chemical, and ecological changes across the planet. There is wide consensus among scientific organizations and climatologists that these broad effects, known as climate change, are the result of contemporary human activity. Climate change poses threats to human health, safety, and security. Children are uniquely vulnerable to these threats. The effects of climate change on child health include physical and psychological sequelae of weather disasters, increased heat stress, decreased air quality, altered disease patterns of some climate-sensitive infections, and food, water, and nutrient insecurity in vulnerable regions. Prompt implementation of mitigation and adaptation strategies will protect children against worsening of the problem and its associated health effects. This technical report reviews the nature of climate change and its associated child health effects and supports the recommendations in the accompanying policy statement on climate change and children's health. Copyright © 2015 by the American Academy of Pediatrics.

Drug repurposing and human parasitic protozoan diseases

PubMed Central

Andrews, Katherine T.; Fisher, Gillian; Skinner-Adams, Tina S.

2014-01-01

Parasitic diseases have an enormous health, social and economic impact and are a particular problem in tropical regions of the world. Diseases caused by protozoa and helminths, such as malaria and schistosomiasis, are the cause of most parasite related morbidity and mortality, with an estimated 1.1 million combined deaths annually. The global burden of these diseases is exacerbated by the lack of licensed vaccines, making safe and effective drugs vital to their prevention and treatment. Unfortunately, where drugs are available, their usefulness is being increasingly threatened by parasite drug resistance. The need for new drugs drives antiparasitic drug discovery research globally and requires a range of innovative strategies to ensure a sustainable pipeline of lead compounds. In this review we discuss one of these approaches, drug repurposing or repositioning, with a focus on major human parasitic protozoan diseases such as malaria, trypanosomiasis, toxoplasmosis, cryptosporidiosis and leishmaniasis. PMID:25057459

Multidimensional Scaling Analysis of the Dynamics of a Country Economy

PubMed Central

Mata, Maria Eugénia

2013-01-01

This paper analyzes the Portuguese short-run business cycles over the last 150 years and presents the multidimensional scaling (MDS) for visualizing the results. The analytical and numerical assessment of this long-run perspective reveals periods with close connections between the macroeconomic variables related to government accounts equilibrium, balance of payments equilibrium, and economic growth. The MDS method is adopted for a quantitative statistical analysis. In this way, similarity clusters of several historical periods emerge in the MDS maps, namely, in identifying similarities and dissimilarities that identify periods of prosperity and crises, growth, and stagnation. Such features are major aspects of collective national achievement, to which can be associated the impact of international problems such as the World Wars, the Great Depression, or the current global financial crisis, as well as national events in the context of broad political blueprints for the Portuguese society in the rising globalization process. PMID:24294132

Eliminating the Neglected Tropical Diseases: Translational Science and New Technologies.

PubMed

Hotez, Peter J; Pecoul, Bernard; Rijal, Suman; Boehme, Catharina; Aksoy, Serap; Malecela, Mwelecele; Tapia-Conyer, Roberto; Reeder, John C

2016-03-01

Today, the World Health Organization recognizes 17 major parasitic and related infections as the neglected tropical diseases (NTDs). Despite recent gains in the understanding of the nature and prevalence of NTDs, as well as successes in recent scaled-up preventive chemotherapy strategies and other health interventions, the NTDs continue to rank among the world's greatest global health problems. For virtually all of the NTDs (including those slated for elimination under the auspices of a 2012 London Declaration for NTDs and a 2013 World Health Assembly resolution [WHA 66.12]), additional control mechanisms and tools are needed, including new NTD drugs, vaccines, diagnostics, and vector control agents and strategies. Elimination will not be possible without these new tools. Here we summarize some of the key challenges in translational science to develop and introduce these new technologies in order to ensure success in global NTD elimination efforts.

Venus Chasmata: A Lithospheric Stretching Model

NASA Technical Reports Server (NTRS)

Solomon, S. C.; Head, J. W.

1985-01-01

An outstanding problem for Venus is the characterization of its style of global tectonics, an issue intimately related to the dominant mechanism of lithospheric heat loss. Among the most spectacular and extensive of the major tectonic features on Venus are the chasmata, deep linear valleys generally interpreted to be the products of lithospheric extension and rifting. Systems of chasmata and related features can be traced along several tectonic zones up to 20,000 km in linear extent. A lithospheric stretching model was developed to explain the topographic characteristics of Venus chasmata and to constrain the physical properties of the Venus crust and lithosphere.

Acute dysphagia in an octogenarian: an unusual case of tetanus.

PubMed

Giordano, Mauro; Ciarambino, Tiziana; Di Bella, Olimpia; Finelli, Angelo; Ferrara, Nicola; Paolisso, Giuseppe

2014-06-01

Tetanus is a major worldwide health problem, and its global incidence has been estimated to be approximately 1 million cases per year. In particular, tetanus is more frequent in the elderly as compared with adults. We report a case of an octogenarian who presented with dysphagia and tremors as the only clinical symptoms. During hospitalization, the patient's clinical conditions worsened rapidly, and, although in absence of the classic clinical presentation (trisma, nuchal rigidity, and opisthotonus), a diagnosis of tetanus was suspected. Thus, the patient underwent a tetanus immunoglobulin immunization and antibiotic therapy with excellent clinical recovery.

The quiet revolution of numerical weather prediction.

PubMed

Bauer, Peter; Thorpe, Alan; Brunet, Gilbert

2015-09-03

Advances in numerical weather prediction represent a quiet revolution because they have resulted from a steady accumulation of scientific knowledge and technological advances over many years that, with only a few exceptions, have not been associated with the aura of fundamental physics breakthroughs. Nonetheless, the impact of numerical weather prediction is among the greatest of any area of physical science. As a computational problem, global weather prediction is comparable to the simulation of the human brain and of the evolution of the early Universe, and it is performed every day at major operational centres across the world.

The environment becomes a political issue. Highlights of the Brundtland Commission Report.

PubMed

1988-03-01

The Report of the Brundtland Commission (World Commission on Environment and Development) has been released by the UN. The Report points out that environmental survival requires development and development is only possible if the resources of the global environment are conserved. Although the UN and the World Bank must make commitments to development, each nation must devise its own strategy because development is inextricably linked to political, economic, and social factors such as poverty, overpopulation and the status of women. The Report makes 3 specific recommendations: 1) An independent body should be set up to assess global risks; 2) A universal declaration on environment and development should be made and followed by a convention; and 3) The UN General Assembly should set up a UN Program on Sustainable Development. The highest priority should be given to finding alternatives to nuclear energy as well as making the use of nuclear energy safer. Other major environmental problems include desertification, acid rain, the "greenhouse effect" and its impact on global climate and sea levels, and the destruction of the ozone layer with concomitant increase in cancer.

Black Carbon and Precipitation: An Energetics Perspective

NASA Astrophysics Data System (ADS)

Sand, M.; Samset, B. H.; Stjern, C.; Tsigaridis, K.; Myhre, G.

2017-12-01

Airborne Black Carbon (BC) can affect precipitation rates, both globally and regionally, through a number of mechanisms. Many studies have investigated the impact of the direct radiative effect, indirect modification of cloud properties and rapid adjustments (the semidirect effect), individually or in combination, but the net climate impacts of anthropogenic and natural BC are still highly uncertain. A particular problem is the complex behavior of BC-climate interactions with altitude. Since the atmospheric residence time, ageing and removal processes for BC are also poorly known, differences in vertical BC concentration profiles between models and intercomparison experiments greatly complicate the picture. Recently, precipitation changes predicted by climate models have been studied in the framework of changes to the global and regional energy balance. Here, we employ such an energetics perspective to simulations of BC inserted at isolated altitudes, in two major climate models (NCAR CESM1, NASA GISS). We show the resulting regional and global changes to precipitation, and analyze it in both in terms of individual components of radiative forcing, and the atmospheric energy balance. The results are presented in the context of recent literature.

Innovative Approaches to Hypertension Control in Low- and Middle-Income Countries

PubMed Central

Vedanthan, Rajesh; Bernabe-Ortiz, Antonio; Herasme, Omarys I.; Joshi, Rohina; Lopez-Jaramillo, Patricio; Thrift, Amanda G.; Webster, Jacqui; Webster, Ruth; Yeates, Karen; Gyamfi, Joyce; Ieremia, Merina; Johnson, Claire; Kamano, Jemima H.; Lazo-Porras, Maria; Limbani, Felix; Liu, Peter; McCready, Tara; Miranda, J. Jaime; Mohan, Sailesh; Ogedegbe, Olugbenga; Oldenburg, Brian; Ovbiagele, Bruce; Owolabi, Mayowa; Peiris, David; Ponce-Lucero, Vilarmina; Praveen, Devarsetty; Pillay, Arti; Schwalm, Jon-David; Tobe, Sheldon W.; Trieu, Kathy; Yusoff, Khalid; Fuster, Valentin

2016-01-01

Elevated blood pressure, a major risk factor for ischemic heart disease, heart failure, and stroke, is the leading global risk for mortality. Despite global efforts to combat hypertension, it continues to exert a significant health and economic burden on low- and middle-income country (LMIC) populations, thereby triggering the need to address the problem by way of novel approaches. The Global Alliance for Chronic Diseases has funded 15 research projects related to hypertension control in low-resource settings worldwide. These research projects have developed and evaluated several important innovative approaches to hypertension control, including: community engagement, salt reduction, salt substitution, task redistribution, mHealth, and fixed-dose combination therapies. In this paper, we briefly review the rationale for each of these innovative approaches, as well as summarize the experience of some of the research teams in these respective areas. Where relevant, we also draw upon the wider literature to illustrate how these approaches to hypertension control are being implemented in LMICs. The studies outlined in this report demonstrate innovative and practical methods of implementing for improving hypertension control in diverse environments and contexts worldwide. PMID:27886793

Multi-period natural gas market modeling Applications, stochastic extensions and solution approaches

NASA Astrophysics Data System (ADS)

Egging, Rudolf Gerardus

This dissertation develops deterministic and stochastic multi-period mixed complementarity problems (MCP) for the global natural gas market, as well as solution approaches for large-scale stochastic MCP. The deterministic model is unique in the combination of the level of detail of the actors in the natural gas markets and the transport options, the detailed regional and global coverage, the multi-period approach with endogenous capacity expansions for transportation and storage infrastructure, the seasonal variation in demand and the representation of market power according to Nash-Cournot theory. The model is applied to several scenarios for the natural gas market that cover the formation of a cartel by the members of the Gas Exporting Countries Forum, a low availability of unconventional gas in the United States, and cost reductions in long-distance gas transportation. 1 The results provide insights in how different regions are affected by various developments, in terms of production, consumption, traded volumes, prices and profits of market participants. The stochastic MCP is developed and applied to a global natural gas market problem with four scenarios for a time horizon until 2050 with nineteen regions and containing 78,768 variables. The scenarios vary in the possibility of a gas market cartel formation and varying depletion rates of gas reserves in the major gas importing regions. Outcomes for hedging decisions of market participants show some significant shifts in the timing and location of infrastructure investments, thereby affecting local market situations. A first application of Benders decomposition (BD) is presented to solve a large-scale stochastic MCP for the global gas market with many hundreds of first-stage capacity expansion variables and market players exerting various levels of market power. The largest problem solved successfully using BD contained 47,373 variables of which 763 first-stage variables, however using BD did not result in shorter solution times relative to solving the extensive-forms. Larger problems, up to 117,481 variables, were solved in extensive-form, but not when applying BD due to numerical issues. It is discussed how BD could significantly reduce the solution time of large-scale stochastic models, but various challenges remain and more research is needed to assess the potential of Benders decomposition for solving large-scale stochastic MCP. 1 www.gecforum.org

Guaranteed convergence of the Hough transform

NASA Astrophysics Data System (ADS)

Soffer, Menashe; Kiryati, Nahum

1995-01-01

The straight-line Hough Transform using normal parameterization with a continuous voting kernel is considered. It transforms the colinearity detection problem to a problem of finding the global maximum of a two dimensional function above a domain in the parameter space. The principle is similar to robust regression using fixed scale M-estimation. Unlike standard M-estimation procedures the Hough Transform does not rely on a good initial estimate of the line parameters: The global optimization problem is approached by exhaustive search on a grid that is usually as fine as computationally feasible. The global maximum of a general function above a bounded domain cannot be found by a finite number of function evaluations. Only if sufficient a-priori knowledge about the smoothness of the objective function is available, convergence to the global maximum can be guaranteed. The extraction of a-priori information and its efficient use are the main challenges in real global optimization problems. The global optimization problem in the Hough Transform is essentially how fine should the parameter space quantization be in order not to miss the true maximum. More than thirty years after Hough patented the basic algorithm, the problem is still essentially open. In this paper an attempt is made to identify a-priori information on the smoothness of the objective (Hough) function and to introduce sufficient conditions for the convergence of the Hough Transform to the global maximum. An image model with several application dependent parameters is defined. Edge point location errors as well as background noise are accounted for. Minimal parameter space quantization intervals that guarantee convergence are obtained. Focusing policies for multi-resolution Hough algorithms are developed. Theoretical support for bottom- up processing is provided. Due to the randomness of errors and noise, convergence guarantees are probabilistic.

Teaching about the Global Environment.

ERIC Educational Resources Information Center

Blackburn, Anne M.

1985-01-01

Social studies educators hold an important key to our future success in the management of "spaceship earth." Students must be made aware of the global environment and the many problems facing it. These problems are discussed. (RM)

Enhancing Global Competitiveness: Benchmarking Airline Operational Performance in Highly Regulated Environments

NASA Technical Reports Server (NTRS)

Bowen, Brent D.; Headley, Dean E.; Kane, Karisa D.

1998-01-01

Enhancing competitiveness in the global airline industry is at the forefront of attention with airlines, government, and the flying public. The seemingly unchecked growth of major airline alliances is heralded as an enhancement to global competition. However, like many mega-conglomerates, mega-airlines will face complications driven by size regardless of the many recitations of enhanced efficiency. Outlined herein is a conceptual model to serve as a decision tool for policy-makers, managers, and consumers of airline services. This model is developed using public data for the United States (U.S.) major airline industry available from the U/S. Department of Transportation, Federal Aviation Administration, the National Aeronautics and Space Administration, the National Transportation Safety Board, and other public and private sector sources. Data points include number of accidents, pilot deviations, operational performance indicators, flight problems, and other factors. Data from these sources provide opportunity to develop a model based on a complex dot product equation of two vectors. A row vector is weighted for importance by a key informant panel of government, industry, and consumer experts, while a column vector is established with the factor value. The resulting equation, known as the national Airline Quality Rating (AQR), where Q is quality, C is weight, and V is the value of the variables, is stated Q=C[i1-19] x V[i1-19]. Looking at historical patterns of AQR results provides the basis for establishment of an industry benchmark for the purpose of enhancing airline operational performance. A 7 year average of overall operational performance provides the resulting benchmark indicator. Applications from this example can be applied to the many competitive environments of the global industry and assist policy-makers faced with rapidly changing regulatory challenges.

Can herbicide safeners allow selective control of weedy rice infesting rice crops?

PubMed

Busi, Roberto; Nguyen, Nghia K; Chauhan, Bhagirath S; Vidotto, Francesco; Tabacchi, Maurizio; Powles, Stephen B

2017-01-01

Rice is a major field crop of paramount importance for global food security. However, the increased adoption of more profitable and resource-efficient direct-seeded rice (DSR) systems has contributed to greater weed infestations, including weedy rice, which has become a severe problem in several Asian regions. In this study we have developed a conceptually novel method to protect rice plants at high doses of clomazone and triallate. The insecticide phorate applied to rice seeds provided a substantial level of protection against the herbicides clomazone or triallate. A quantity of 15 kg phorate ha -1 significantly increased the LD 50 values, which were more than twofold greater than for rice plants treated only with clomazone. A quantity of 20 kg phorate ha -1 in combination with 2000 g triallate ha -1 safened rice plants (80% survival) with LD 50 >3.4-fold greater than in phorate-untreated rice. Weed control efficacy was not lowered by the presence of phorate-treated rice seeds. Weedy rice is one of the most damaging global weeds and a major threat to DSR systems. In this study we have developed a proof-of-concept method to allow selective weedy rice control in rice crops. We call for herbicide discovery programmes and research to identify candidate safener and herbicide combinations to achieve selective herbicide control of weedy rice and alleviate weed infestations in global rice crops. © 2016 Society of Chemical Industry. © 2016 Society of Chemical Industry.

Assessment of local GNSS baselines at co-location sites

NASA Astrophysics Data System (ADS)

Herrera Pinzón, Iván; Rothacher, Markus

2018-01-01

As one of the major contributors to the realisation of the International Terrestrial Reference System (ITRS), the Global Navigation Satellite Systems (GNSS) are prone to suffer from irregularities and discontinuities in time series. While often associated with hardware/software changes and the influence of the local environment, these discrepancies constitute a major threat for ITRS realisations. Co-located GNSS at fundamental sites, with two or more available instruments, provide the opportunity to mitigate their influence while improving the accuracy of estimated positions by examining data breaks, local biases, deformations, time-dependent variations and the comparison of GNSS baselines with existing local tie measurements. With the use of co-located GNSS data from a subset sites of the International GNSS Service network, this paper discusses a global multi-year analysis with the aim of delivering homogeneous time series of coordinates to analyse system-specific error sources in the local baselines. Results based on the comparison of different GNSS-based solutions with the local survey ties show discrepancies of up to 10 mm despite GNSS coordinate repeatabilities at the sub-mm level. The discrepancies are especially large for the solutions using the ionosphere-free linear combination and estimating tropospheric zenith delays, thus corresponding to the processing strategy used for global solutions. Snow on the antennas causes further problems and seasonal variations of the station coordinates. These demonstrate the need for a permanent high-quality monitoring of the effects present in the short GNSS baselines at fundamental sites.

Global pediatric environmental health.

PubMed

Guidotti, Tee L; Gitterman, Benjamin A

2007-04-01

Children are uniquely vulnerable to environmental health problems. Developed countries report as the most common problems ambient (outdoor) air pollution and lead. Developing countries have a wider range of common problems, including childhood injuries, indoor air pollution, infectious disease, and poor sanitation with unsafe water. Globally, the agencies of the United Nations act to protect children and perform essential reporting and standards-setting functions. Conditions vary greatly among countries and are not always better in developing countries. Protecting the health of children requires strengthening the public health and medical systems in every country, rather than a single global agenda.

Global Collaborations - Prospects and Problems

NASA Astrophysics Data System (ADS)

Corbett, Ian

2005-04-01

International collaboration has long been a feature of science. Collaborative investments in joint facilities and projects have grown considerably over the past 20-40 years, and many projects have been multinational from the start. This has been particularly true in Europe, where intergovernmental organizations such as CERN, ESA, and ESO have enabled European countries to carry out forefront science with state-of-art facilites which would have been beyond the capabilities of any one country. A brief survey of these organizations, their structure, and the possible reasons behind their success is given. The transition from regional to global creates new problems. Global scale projects face a range of generic issues which must be addressed and overcome if the project is to be a success. Each project has its own specific boundary conditions and each adopts an approach best fitted to its own objectives and constraints. Experience with billion dollar projects such as the SSC, LHC, and ITER shows the key problem areas and demonstrates the importance of preparatory work in the early stages to settle issues such as schedule, funding, location, legal and managerial structure, and oversight. A range of current and proposed intercontinental or global projects - so- called ``Megascience Projects" - is reviewed. Such projects, originally a feature of space and particle physics, are now becoming more common, and very large projects in astronomy, for example ALMA and 50 - 100m telescopes, and other areas of physics now fall into the `global' category. These projects are on such a large scale, from any scientific, managerial, financial or political perspective, and have such global importance, that they have necessarily been conceived as international from the outset. Increasing financial pressures on governments and funding agencies in the developed countries place additional demands on the project planning. The contrasting approaches, problems faced, and progress made in various projects will be analyzed and possible lessions drawn out. The role which can be played in the early stages by bodies such as the OECD Global Science Forum and G-8 Carnegie Meetings, where science policy makers meet, is examined. Experience shows that these valuable `scene setting' discussions have to be informed by coordinated input from the scientific community and must be followed up by more detailed discussions between funding agencies or their equivalent, because decision making requires the development of a consensus amongst the participants. This process can be illustrated most effectively by the care with which the ideas for the International Linear Collider have been and are being developed. Agreement on building and operating a facility is not the end of the story. The legitimate desire of scientists in all other countries to be able to participate in exploiting a major new facility has to be taken into account, and that introduces a range of proprietary and sociological issues over data access and rights, and now, with the explosion in computing and storage powers, in data archiving support. These are issues which can be addressed within the scientific community and taken to the political arena via such bodies as the OECD Global Science Forum.

The global collaboration on traumatic stress.

PubMed

Schnyder, Ulrich; Schäfer, Ingo; Aakvaag, Helene F; Ajdukovic, Dean; Bakker, Anne; Bisson, Jonathan I; Brewer, Douglas; Cloitre, Marylène; Dyb, Grete A; Frewen, Paul; Lanza, Juliana; Le Brocque, Robyne; Lueger-Schuster, Brigitte; Mwiti, Gladys K; Oe, Misari; Rosner, Rita; Schellong, Julia; Shigemura, Jun; Wu, Kitty; Olff, Miranda

2017-01-01

Trauma is a global issue. The great majority of the global burden of disease arising from mental health conditions occurs in low- and middle-income countries (LMICs), among populations in political, economic, and/or cultural transition and those struck by forced migration. These mental health problems frequently arise as a result of traumatic events that adversely affect adults, children, and families, including war, mass violence, natural disasters, and accidents. In response to this, the International Society for Traumatic Stress Studies (ISTSS) launched the Global Initiative to have a stronger global impact on trauma-related issues. As part of this initiative, the Global Collaboration was established by representatives of eight professional organizations active in the field of traumatic stress. The group decided to focus on childhood abuse and neglect as its first collaboration. They collected guidelines worldwide, providing the basis for a synthesized core guide for prevention and treatment that can be customized for specific cultural contexts. The resulting 'Internet information on Childhood Abuse and Neglect' (iCAN) is a comprehensive guide for adults who have been affected by childhood abuse and neglect, as well as for the survivors' significant others. It is currently provided in eight languages, and is freely available at the homepage of ISTSS and other websites. A second achievement of the Global Collaboration is the validation of the Computerized Childhood Attachment and Relational Trauma Screen (CARTS), a self-report measure designed to measure occurrences of childhood maltreatment, and its translation into multiple languages, including Croatian, Dutch, French, Georgian, German, Italian, Japanese, Norwegian, Russian, and Spanish. A study is currently planned to collect normative responses to the questionnaire, and to conduct cross-cultural comparisons. The Global Collaboration's success may be seen as an encouraging step towards a truly global structure in the field of traumatic stress.

Educational Activity as a Problem of Adult Education in the Context of Globalization

ERIC Educational Resources Information Center

Folvarochnyi, Ihor

2014-01-01

The article deals with the problem of adult education in the context of globalization. The analysis of scientific pedagogical literature devoted to studying of some aspects of educational activity in adult education has been conducted. The problem of public institutions development and activity has been analyzed in the broad context of…

Dysphagia in the high-risk infant: potential factors and mechanisms123

PubMed Central

Jadcherla, Sudarshan

2016-01-01

Neonatal dysphagia, or abnormalities of swallowing, represent a major global problem, and consequences of dysfunctional feeding patterns carry over into infancy and toddler age groups. Growth, development, and independent feeding skills are all delayed among high-risk infants. Such a group comprises premature birth, low-birth-weight, congenital anomalies, perinatal asphyxia, postsurgical, and sepsis categories. The conflict between pathophysiologic and pragmatic feeding strategies remains a major conundrum and is largely due to a lack of validated diagnostic approaches amid heterogeneity of the patient phenotype. Thus, well-tested feeding management strategies that can be generalizable are lacking. Furthermore, the aerodigestive symptoms and signs, potential risk factors, and contributory etiologies remain nonspecific. This article presents mechanistic evidence related to the pathophysiologic basis of neonatal dysphagia as well as potential opportunities to improve feeding abilities and long-term development. PMID:26791178

Impact of age on cardiovascular risk: implications for cardiovascular disease management.

PubMed

Tuomilehto, Jaakko

2004-05-01

Cardiovascular disease (CVD) represents a major global healthcare problem. The prevalence of this condition increases with age. As many countries around the world are experiencing an increase in the proportion of elderly people in the population, this raises serious issues for cardiac and cerebrovascular disease prevention and management. A wealth of data has established smoking, dyslipidemia, hypertension and type 2 diabetes as major risk factors for cardiac and cerebrovascular events. This article reviews the evidence that links these metabolic risk factors with an increased risk of complications, and assesses the data concerning how risk changes with age. This review also focuses on how these conditions can be optimally managed and whether treatment outcomes are affected by age. The current status of research is assessed and issues which remain to be resolved are highlighted.

Sleep disturbances in patients with major depressive disorder: incongruence between sleep log and actigraphy.

PubMed

Kung, Pei-Ying; Chou, Kuei-Ru; Lin, Kuan-Chia; Hsu, Hsin-Wei; Chung, Min-Huey

2015-02-01

Depression has become a severe global health problem, and sleeping difficulties are typically associated with depression. The purpose of this study was to investigate the relationships among subjective sleep quality, objective sleep quality, and the sleep hygiene practices of hospitalized patients with major depressive disorder. Daily sleep logs and actigraphy were used to obtain subjective and objective sleep data. Thirty patients were recruited from a regional teaching hospital in Taipei and completed the Hamilton Rating Scale for Depression and the Sleep Hygiene Practice Scale. Significant differences were found between subjective and objective sleep data in patients with major depressive disorder (MDD). For patients with more severe depression, subjective measurements obtained using sleep logs, such as total sleep time and sleep efficiency, were significantly lower than those obtained using actigraphy by controlling for demographics. The results regarding the differences between subjective and objective sleep data can be a reference for care providers when comforting depression patients who complain of sleep disturbance. Copyright © 2014 Elsevier Inc. All rights reserved.

Can prevention eliminate caries?

PubMed

O'Mullane, D

1995-07-01

There are four main factors involved in the carious process: at-risk tooth structure, plaque flora, fermentable carbohydrates, and time. Based on our knowledge of the carious process, four main preventive strategies have been developed over the years, namely, fluorides, fissure sealing, dietary choice, and plaque control. Fluorides are having a major impact on smooth-surface caries; hence, strategies combining fluorides and fissure sealing are very effective. However, use of fissure sealing is still problematic. Changing dietary practices with a view to reducing dental caries seems to be having little impact on a global scale. Plaque control, as practiced routinely by the majority of people, is not sufficient to result in caries reductions. Deprivation and poverty are strongly associated with high caries levels. Although the preventive strategies currently available are likely to result in lower caries levels for many, for logistical reasons and because of factors associated with deprivation and poverty, caries is likely to remain a major public health problem in most communities for the foreseeable future.

Cooperative global optimal preview tracking control of linear multi-agent systems: an internal model approach

NASA Astrophysics Data System (ADS)

Lu, Yanrong; Liao, Fucheng; Deng, Jiamei; Liu, Huiyang

2017-09-01

This paper investigates the cooperative global optimal preview tracking problem of linear multi-agent systems under the assumption that the output of a leader is a previewable periodic signal and the topology graph contains a directed spanning tree. First, a type of distributed internal model is introduced, and the cooperative preview tracking problem is converted to a global optimal regulation problem of an augmented system. Second, an optimal controller, which can guarantee the asymptotic stability of the augmented system, is obtained by means of the standard linear quadratic optimal preview control theory. Third, on the basis of proving the existence conditions of the controller, sufficient conditions are given for the original problem to be solvable, meanwhile a cooperative global optimal controller with error integral and preview compensation is derived. Finally, the validity of theoretical results is demonstrated by a numerical simulation.

Dynamic Constraint Satisfaction with Reasonable Global Constraints

NASA Technical Reports Server (NTRS)

Frank, Jeremy

2003-01-01

Previously studied theoretical frameworks for dynamic constraint satisfaction problems (DCSPs) employ a small set of primitive operators to modify a problem instance. They do not address the desire to model problems using sophisticated global constraints, and do not address efficiency questions related to incremental constraint enforcement. In this paper, we extend a DCSP framework to incorporate global constraints with flexible scope. A simple approach to incremental propagation after scope modification can be inefficient under some circumstances. We characterize the cases when this inefficiency can occur, and discuss two ways to alleviate this problem: adding rejection variables to the scope of flexible constraints, and adding new features to constraints that permit increased control over incremental propagation.

A New Maximum Likelihood Approach for Free Energy Profile Construction from Molecular Simulations

PubMed Central

Lee, Tai-Sung; Radak, Brian K.; Pabis, Anna; York, Darrin M.

2013-01-01

A novel variational method for construction of free energy profiles from molecular simulation data is presented. The variational free energy profile (VFEP) method uses the maximum likelihood principle applied to the global free energy profile based on the entire set of simulation data (e.g from multiple biased simulations) that spans the free energy surface. The new method addresses common obstacles in two major problems usually observed in traditional methods for estimating free energy surfaces: the need for overlap in the re-weighting procedure and the problem of data representation. Test cases demonstrate that VFEP outperforms other methods in terms of the amount and sparsity of the data needed to construct the overall free energy profiles. For typical chemical reactions, only ~5 windows and ~20-35 independent data points per window are sufficient to obtain an overall qualitatively correct free energy profile with sampling errors an order of magnitude smaller than the free energy barrier. The proposed approach thus provides a feasible mechanism to quickly construct the global free energy profile and identify free energy barriers and basins in free energy simulations via a robust, variational procedure that determines an analytic representation of the free energy profile without the requirement of numerically unstable histograms or binning procedures. It can serve as a new framework for biased simulations and is suitable to be used together with other methods to tackle with the free energy estimation problem. PMID:23457427

Global Discontinuity Structure of the Mantle Transition Zone from Finite-Frequency Tomography of SS Precursors

NASA Astrophysics Data System (ADS)

Guo, Z.; Zhou, Y.

2017-12-01

We report global structure of the 410-km and 660-km discontinuities from finite-frequency tomography using frequency-dependent traveltime measurements of SS precursors recorded at the Global Seismological Network (GSN). Finite-frequency sensitivity kernels for discontinuity depth perturbations are calculated in the framework of traveling-wave mode coupling. We parametrize the global discontinuities using a set of spherical triangular grid points and solve the tomographic inverse problem based on singular value decomposition. Our global 410-km and 660-km discontinuity models reveal distinctly different characteristics beneath the oceans and subduction zones. In general, oceanic regions are associated with a thinner mantle transition zone and depth perturbations of the 410-km and 660-km discontinuities are anti-correlated, in agreement with a thermal origin and an overall warm and dry mantle beneath the oceans. The perturbations are not uniform throughout the oceans but show strong small-scale variations, indicating complex processes in the mantle transition zone. In major subduction zones (except for South America where data coverage is sparse), depth perturbations of the 410-km and 660-km discontinuities are correlated, with both the 410-km and the 660-km discontinuities occurring at greater depths. The distributions of the anomalies are consistent with cold stagnant slabs just above the 660-km discontinuity and ascending return flows in a superadiabatic upper mantle.

Food security and sustainable resource management

NASA Astrophysics Data System (ADS)

McLaughlin, Dennis; Kinzelbach, Wolfgang

2015-07-01

The projected growth in global food demand until mid-century will challenge our ability to continue recent increases in crop yield and will have a significant impact on natural resources. The water and land requirements of current agriculture are significantly less than global reserves but local shortages are common and have serious impacts on food security. Recent increases in global trade have mitigated some of the effects of spatial and temporal variability. However, trade has a limited impact on low-income populations who remain dependent on subsistence agriculture and local resources. Potential adverse environmental impacts of increased agricultural production include unsustainable depletion of water and soil resources, major changes in the global nitrogen and phosphorous cycles, human health problems related to excessive nutrient and pesticide use, and loss of habitats that contribute to agricultural productivity. Some typical case studies from China illustrate the connections between the need for increased food production and environmental stress. Sustainable options for decreasing food demand and for increasing production include reduction of food losses on both the producer and consumer ends, elimination of unsustainable practices such as prolonged groundwater overdraft, closing of yield gaps with controlled expansions of fertilizer application, increases in crop yield and pest resistance through advances in biotechnology, and moderate expansion of rain fed and irrigated cropland. Calculations based on reasonable assumptions suggest that such measures could meet the food needs of an increasing global population while protecting the environment.

Global safe anaesthesia and surgery initiatives: implications for anaesthesia in the Pacific region.

PubMed

Cooper, M G; Wake, P B; Morriss, W W; Cargill, P D; McDougall, R J

2016-05-01

In 2015 three major events occurred for global anaesthesia and surgery. In January, the World Bank published Disease Control Priorities 3rd edition (DCP 3rd edition). This volume, Essential Surgery, highlighted the cost effective role of anaesthesia and surgery in global health. In April, the Lancet Commission on Global Surgery released its report "Global Surgery 2030: Evidence and solutions for achieving health, welfare, and economic development". The report focuses on five key areas to promote change including: access to timely surgery, surgical workforce and procedural capability, surgical volume, data collection such as perioperative mortality rate, and financial protection. In May, the 68th World Health Assembly (WHA) voted in favour of Resolution A68/31: Strengthening emergency and essential surgical and anaesthesia care as a component of universal health coverage. The resolution was passed unanimously and it is the first time that surgery and anaesthesia have received such prominence at WHA level. These three events all have profound implications for the provision and access of safe anaesthesia and surgery in the Pacific region in the next 15 years. This article considers some of the regional factors that affect these five key areas, especially with regard to anaesthetic specialist workforce density in different parts of the region. There are many challenges to improve anaesthesia access, safety, and workforce density in the Pacific region. Future efforts, initiatives and support will help address these problems.

Global Partnership in Global Earth Observations

NASA Astrophysics Data System (ADS)

Smirnov, A.; Obersteiner, M.

2007-12-01

The emergence of a global partnership on earth observations will crucially drive the configuration of future observing systems and consequently shape how socio-economic benefits are generated. In this paper we take a game-theoretical approach to model cooperation on building global earth observation systems. We consider several societies whose economies are subject to shocks mimicking major natural disasters. Economies operate optimally and lead to the best possible expected value for the social welfares in the future. In order to increase its welfare even more society can make a decision to invest into a global alerting system which lowers the risk of disasters. We start our investigation from a single-society case and show conditions under which benefits of such investment can be reaped. The propensity to invest increases with economic affluence and degree of vulnerability to natural disasters. We find that for poor and/or less vulnerable countries it is better to forbear from investment. If to consider a situation of multiple societies a strategic gaming situation emerges motivated by the fact that every society will benefit from a global system regardless of whether they invested or not. Our analysis of possible equilibrium solutions shows that similar to the formation of trading blocks (e.g. EU, NAFTA) only in the case of similar societies we will observe cooperation behavior (when all invest) and otherwise we will observe free-riding. This insight, that we might face a prisoners dilemma problem in the formation of a GEOSS, has important implications for the GEO process.

[Future Regulatory Science through a Global Product Development Strategy to Overcome the Device Lag].

PubMed

Tsuchii, Isao

2016-01-01

Environment that created "medical device lag (MDL)" has changed dramatically, and currently that term is not heard often. This was mainly achieved through the leadership of three groups: government, which determined to overcome MDL and took steps to do so; medical societies, which exhibited accountability in trial participation; and MD companies, which underwent a change in mindset that allowed comprehensive tripartite cooperation to reach the current stage. In particular, the global product development strategy (GPDS) of companies in a changing social environment has taken a new-turn with international harmonization trends, like Global Harmonization Task Force and International Council for Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use. As a result, this evolution has created opportunities for treatment with cutting-edge MDs in Japanese society. Simultaneously, it has had a major impact on the planning process of GPDS of companies. At the same time, the interest of global companies has shifted to emerging economies for future potential profit since Japan no longer faces MDL issue. This economic trend makes MDLs a greater problem for manufacturers. From the regulatory science viewpoint, this new environment has not made it easy to plan a global strategy that will be adaptable to local societies. Without taking hasty action, flexible thinking from the global point of view is necessary to enable the adjustment of local strategies to fit the situation on the ground so that the innovative Japanese medical technology can be exported to a broad range of societies.

Global policy for improvement of oral health in the 21st century--implications to oral health research of World Health Assembly 2007, World Health Organization.

PubMed

Petersen, Poul Erik

2009-02-01

The World Health Organization (WHO) Global Oral Health Programme has worked hard over the past 5 years to increase the awareness of oral health worldwide as oral health is important component of general health and quality of life. Meanwhile, oral disease is still a major public health problem in high income countries and the burden of oral disease is growing in many low- and middle income countries. In the World Oral Health Report 2003, the WHO Global Oral Health Programme formulated the policies and necessary actions to the continuous improvement of oral health. The strategy is that oral disease prevention and the promotion of oral health needs to be integrated with chronic disease prevention and general health promotion as the risks to health are linked. The World Health Assembly (WHA) and the Executive Board (EB) are supreme governance bodies of WHO and for the first time in 25 years oral health was subject to discussion by those bodies in 2007. At the EB120 and WHA60, the Member States agreed on an action plan for oral health and integrated disease prevention, thereby confirming the approach of the Oral Health Programme. The policy forms the basis for future development or adjustment of oral health programmes at national level. Clinical and public health research has shown that a number of individual, professional and community preventive measures are effective in preventing most oral diseases. However, advances in oral health science have not yet benefited the poor and disadvantaged populations worldwide. The major challenges of the future will be to translate knowledge and experiences in oral disease prevention and health promotion into action programmes. The WHO Global Oral Health Programme invites the international oral health research community to engage further in research capacity building in developing countries, and in strengthening the work so that research is recognized as the foundation of oral heath policy at global level.

Global optimization methods for engineering design

NASA Technical Reports Server (NTRS)

Arora, Jasbir S.

1990-01-01

The problem is to find a global minimum for the Problem P. Necessary and sufficient conditions are available for local optimality. However, global solution can be assured only under the assumption of convexity of the problem. If the constraint set S is compact and the cost function is continuous on it, existence of a global minimum is guaranteed. However, in view of the fact that no global optimality conditions are available, a global solution can be found only by an exhaustive search to satisfy Inequality. The exhaustive search can be organized in such a way that the entire design space need not be searched for the solution. This way the computational burden is reduced somewhat. It is concluded that zooming algorithm for global optimizations appears to be a good alternative to stochastic methods. More testing is needed; a general, robust, and efficient local minimizer is required. IDESIGN was used in all numerical calculations which is based on a sequential quadratic programming algorithm, and since feasible set keeps on shrinking, a good algorithm to find an initial feasible point is required. Such algorithms need to be developed and evaluated.

Old and new challenges in using species diversity for assessing biodiversity

PubMed Central

Chiarucci, Alessandro; Bacaro, Giovanni; Scheiner, Samuel M.

2011-01-01

Although the maintenance of diversity of living systems is critical for ecosystem functioning, the accelerating pace of global change is threatening its preservation. Standardized methods for biodiversity assessment and monitoring are needed. Species diversity is one of the most widely adopted metrics for assessing patterns and processes of biodiversity, at both ecological and biogeographic scales. However, those perspectives differ because of the types of data that can be feasibly collected, resulting in differences in the questions that can be addressed. Despite a theoretical consensus on diversity metrics, standardized methods for its measurement are lacking, especially at the scales needed to monitor biodiversity for conservation and management purposes. We review the conceptual framework for species diversity, examine common metrics, and explore their use for biodiversity conservation and management. Key differences in diversity measures at ecological and biogeographic scales are the completeness of species lists and the ability to include information on species abundances. We analyse the major pitfalls and problems with quantitative measurement of species diversity, look at the use of weighting measures by phylogenetic distance, discuss potential solutions and propose a research agenda to solve the major existing problems. PMID:21768157

Public health oncology: a framework for progress in low- and middle-income countries.

PubMed

Love, R R; Ginsburg, O M; Coleman, C N

2012-12-01

The problems of cancer are increasing in low- and middle-income countries (LMCs), which now have significant majorities of the global case and mortality burdens. The professional oncology community is being increasingly called upon to define pragmatic and realistic approaches to these problems. Focusing on mortality and case burden outcomes defines public health oncology or population-affecting cancer medicine. We use this focus to consider practical approaches. The greatest cancer burdens are in Asia. A public health oncology perspective mandates: first, addressing the major and social challenges of cancer medicine for populations: human rights, health systems, corruption, and our limited knowledge base for value-conscious interventions. Second, adoption of evolving concepts and models for sustainable development in LMCs. Third, clear and realistic statements of action and inaction affecting populations, grounded in our best cancer science, and attention to these. Finally, framing the goals and challenges for population-affecting cancer medicine requires a change in paradigm from historical top-down models of technology transfer, to one which is community-grounded and local-evidence based. Public health oncology perspectives define clear focus for much needed research on country-specific practical approaches to cancer control.

Public health oncology: a framework for progress in low- and middle-income countries†

PubMed Central

Love, R. R.; Ginsburg, O. M.; Coleman, C. N.

2012-01-01

Background The problems of cancer are increasing in low- and middle-income countries (LMCs), which now have significant majorities of the global case and mortality burdens. The professional oncology community is being increasingly called upon to define pragmatic and realistic approaches to these problems. Patients and methods Focusing on mortality and case burden outcomes defines public health oncology or population-affecting cancer medicine. We use this focus to consider practical approaches. Results The greatest cancer burdens are in Asia. A public health oncology perspective mandates: first, addressing the major and social challenges of cancer medicine for populations: human rights, health systems, corruption, and our limited knowledge base for value-conscious interventions. Second, adoption of evolving concepts and models for sustainable development in LMCs. Third, clear and realistic statements of action and inaction affecting populations, grounded in our best cancer science, and attention to these. Finally, framing the goals and challenges for population-affecting cancer medicine requires a change in paradigm from historical top-down models of technology transfer, to one which is community-grounded and local-evidence based. Conclusion Public health oncology perspectives define clear focus for much needed research on country-specific practical approaches to cancer control. PMID:23087162

Coming to terms: toward a North-South bargain for the environment.

PubMed

Speth, J G

1989-06-01

To attack the major environmental problems, global warming, natural resource losses, and loss of biological diversity, an understanding between the industrialized and developing countries must occur. Weather patterns and sea levels are being affected by global warming which is caused by the use of fossil fuels and deforestation. The industrialized countries must cut back on the use of fossil fuels, and developing countries need to slow the process of deforestation. The loss of genetic resources and the extinction of species is happening rapidly, and most of it is in the tropical forests of developing countries. The developing countries are more dependent on their natural resources, forests, minerals, soils, and fisheries than industrialized countries. They are being depleted more rapidly with the population growth, social inequalities, and poor policies. Industrial countries are partly to blame also since they make investment and development decisions without concerns for the environment. The 4 major actions that can be initiated by industrialized countries are as follows. The initiation of national and international movements to reduce gas emissions that cause the greenhouse effect. The increased distribution of new technology and financing for population programs, sustainable development and environmental protection. The reduction of the external dept of developing countries, and the creation of programs to give technical assistance, scientific and other training for environmental problems of developing countries. Financial assistance can be linked to population programs and to environmental issues of the developing countries. Carbon dioxide taxes could be used to finance forest management and ecological zoning. The exchange of forest conservation for debt relief is a possible solution. Any dept restructuring plan should include strong environmental conservation provisions and policy reform requirements.

A case study of global health at the university: implications for research and action

PubMed Central

Pinto, Andrew D.; Cole, Donald C.; ter Kuile, Aleida; Forman, Lisa; Rouleau, Katherine; Philpott, Jane; Pakes, Barry; Jackson, Suzanne; Muntaner, Carles

2014-01-01

Background Global health is increasingly a major focus of institutions in high-income countries. However, little work has been done to date to study the inner workings of global health at the university level. Academics may have competing objectives, with few mechanisms to coordinate efforts and pool resources. Objective To conduct a case study of global health at Canada's largest health sciences university and to examine how its internal organization influences research and action. Design We drew on existing inventories, annual reports, and websites to create an institutional map, identifying centers and departments using the terms ‘global health’ or ‘international health’ to describe their activities. We compiled a list of academics who self-identified as working in global or international health. We purposively sampled persons in leadership positions as key informants. One investigator carried out confidential, semi-structured interviews with 20 key informants. Interview notes were returned to participants for verification and then analyzed thematically by pairs of coders. Synthesis was conducted jointly. Results More than 100 academics were identified as working in global health, situated in numerous institutions, centers, and departments. Global health academics interviewed shared a common sense of what global health means and the values that underpin such work. Most academics interviewed expressed frustration at the existing fragmentation and the lack of strategic direction, financial support, and recognition from the university. This hampered collaborative work and projects to tackle global health problems. Conclusions The University of Toronto is not exceptional in facing such challenges, and our findings align with existing literature that describes factors that inhibit collaboration in global health work at universities. Global health academics based at universities may work in institutional siloes and this limits both internal and external collaboration. A number of solutions to address these challenges are proposed. PMID:25172428

Environmental concerns and diet in Singapore.

PubMed

Burger, Joanna; Fleischer, Jennifer; Jeitner, Chris; Gochfeld, Michael

2003-08-08

Many factors affect how people perceive the world and their environment, and how such perceptions affect lifestyle decisions, yet the relationship between personal perceptions about environmental hazards and diet is rarely examined. In this study, environmental concerns on a local and global scale were examined, along with dietary patterns, to determine if there were associations and age-related differences. The hypothesis that concerns about water pollution might be reflected in choices about seafood consumption was examined. Many aspects of dietary choices varied significantly by age, including (1) younger people ate more "fast food" than others, (2) subjects aged 22-32 yr ate more meals in restaurants than older or younger people, (3) older individuals drank more tea than younger subjects, while younger people drank more soda than older people, and (4) there were few significant differences in total fish and shellfish meals, although young people ate more meals of other types of meat. Individuals who rated their health the best reported significantly fewer seafood meals than others. People who listed pollution as the major environmental problem did not consume seafood less often than others. While pollution was listed as the most important environmental problem globally, people distinguished between air and water pollution only for Singapore. Although Singapore, with its rapidly expanding economy, has reason to be concerned about both water and air pollution, only 14% of those listing pollution as the main Singapore environmental problem mentioned "water pollution." Singapore has been able to take measures to reduce water pollution from internal sources. Respondents considered air pollution a greater problem, perhaps reflecting recent haze disasters from deliberately set forest fires in Indonesia, which are beyond the direct control of Singapore or Singaporeans.

Global Health Education and Advocacy: Using BMJ Case Reports to Tackle the Social Determinants of Health.

PubMed

Douthit, Nathan T; Biswas, Seema

2018-01-01

Since 2013, BMJ Case Reports (http://casereports.bmj.com/) has published over 70 global health case reports from five continents, written by doctors, nurses, students, and allied health professionals. These cases, a burgeoning repository of evidence of how real patients are affected by disease, trauma, violence, sexual assault, conflict, migration, adverse living and working conditions, and poor access to health care, discuss, in addition to clinicopathological findings, the global health problems affecting each patient. The global health problem analysis examines the problems of individual patients, critically appraises the literature, and describes actual and potential solutions for the patient, the local community, and patients affected by similar issues across the world. At present global health literature and learning materials lack a patient focus and real-life context in the analysis of global health problems. BMJ Case Reports global health case reports are a unique and important tool to learn about and advocate for change in the social, political, cultural, and financial determinants of health as they affect real patients. This growing evidence base brings together clinicians, local service providers, policy makers, and government and non-governmental institutions to effect real change in patients' lives toward improving health. Each global health case report is an excellent resource for learning, and together, these case reports provide essential reading for anyone embarking on a career in global health, and writing their own case report. The online course (http://casereports.bmj.com/site/misc/GHMA_Mar_2017.pptx) at BMJ Case Reports uses these cases and is free to access.

An efficient method for generalized linear multiplicative programming problem with multiplicative constraints.

PubMed

Zhao, Yingfeng; Liu, Sanyang

2016-01-01

We present a practical branch and bound algorithm for globally solving generalized linear multiplicative programming problem with multiplicative constraints. To solve the problem, a relaxation programming problem which is equivalent to a linear programming is proposed by utilizing a new two-phase relaxation technique. In the algorithm, lower and upper bounds are simultaneously obtained by solving some linear relaxation programming problems. Global convergence has been proved and results of some sample examples and a small random experiment show that the proposed algorithm is feasible and efficient.

Improving global health - is tourism's role in poverty elimination perpetuating poverty, powerlessness and 'ill-being'?

PubMed

Bauer, Irmgard L

2017-01-01

The spectrum of challenges for public health in a global context is ever expanding. It is difficult for health professionals to keep informed about details of key issues affecting global health determinants such as poverty. Tourism is seen as one strategy to eliminate poverty in developing countries and to improve global health, but the industry struggles with keeping its promise. Apart from often negative impacts on the well-being of local communities, it also turns out not to be as altruistic as it appears at first sight. Discourses largely focus on power and control of the non-poor over the poor despite all the rhetoric to the contrary. Economic aspects still dictate the debate rather than local people's understanding of well-being. Only with a major shift in the approach to local populations, acknowledging the communities' right to self-determination and accepting them as equal partners with access to genuine benefits, will this disturbing imbalance be redressed and allow better health for more people possible. Public health professionals should question claims about the beneficial influence of tourism in poor regions and not lower their vigilance for poverty-related health problems, so that the poor are not overlooked when all other stakeholders are busy with their own agenda.

Increasing population and declining biological resources in the context of global change and globalization.

PubMed

Ramakrishnan, P S

2001-11-01

In the context of over-consumption of natural resources in the name of development and rapid industrialization by a small section of the human population that is rapidly growing, the world is currently faced with a variety of environmental uncertainties. 'Global change' covering a whole variety of ecological issues, and 'globalization' in an economic sense, are two major phenomena that are responsible for these uncertainties. There is increasing evidence to suggest that the developing countries more than the developed, particularly the marginalized traditional (those living close to nature and natural resources) societies would be the worst sufferers. In order to cope with this problem in a situation where the traditional societies have to cope with rapidly depleting biodiversity on which they are dependant for their livelihood, there is an urgent need to explore additional pathways for sustainable management of natural resources and societal development. Such pathways should be based on a landscape management strategy, that takes into consideration the rich traditional ecological knowledge (TEK) that these societies have. This is critical because TEK is the connecting link between conservation and sustainable development. This paper explores the possibilities in this direction through a balanced approach to development, that links the 'traditional' with the 'modern', in a location-specific way.

3D Reconnection and SEP Considerations in the CME-Flare Problem

NASA Astrophysics Data System (ADS)

Moschou, S. P.; Cohen, O.; Drake, J. J.; Sokolov, I.; Borovikov, D.; Alvarado Gomez, J. D.; Garraffo, C.

2017-12-01

Reconnection is known to play a major role in particle acceleration in both solar and astrophysical regimes, yet little is known about its connection with the global scales and its comparative contribution in the generation of SEPs with respect to other acceleration mechanisms, such as the shock at a fast CME front, in the presence of a global structure such as a CME. Coupling efforts, combining both particle and global scales, are necessary to answer questions about the fundamentals of the energetic processes evolved. We present such a coupling modeling effort that looks into particle acceleration through reconnection in a self-consistent CME-flare model in both particle and fluid regimes. Of special interest is the supra-thermal component of the acceleration due to the reconnection that will at a later time interact colliding with the solar atmospheric material of the more dense chromospheric layer and radiate in hard X- and γ-rays for super-thermal electrons and protons respectively. Two cutting edge computational codes are used to capture the global CME and flare dynamics, specifically a two fluid MHD code and a 3D PIC code for the flare scales. Finally, we are connecting the simulations with current observations in different wavelengths in an effort to shed light to the unified CME-flare picture.

The Discovery of Global Warming

NASA Astrophysics Data System (ADS)

MacCracken, Michael C.

2004-07-01

At the beginning of the twentieth century, the prospect of ``global warming'' as a result of human activities was thought to be far off, and in any case, likely to be beneficial. As we begin the twenty-first century, science adviser to the British government, Sir David King, has said that he considers global warming to be the world's most important problem, including terrorism. Yet, dealing with it has become the subject of a contentious international protocol, numerous conferences of international diplomats, and major scientific assessments and research programs. Spencer Weart, who is director of the Center for History of Physics of the American Institute of Physics, has taken on the challenge of explaining how this came to be. In the tradition of the Intergovernmental Panel on Climate Change (IPCC), which was established in 1988 to evaluate and assess the state of global warming science, this book is roughly equivalent to the Technical Summary, in terms of its technical level, being quite readable, but with substantive content about the main lines of evidence. Underpinning this relatively concise presentation, there is a well-developed-and still developing-Web site that, like the detailed chapters of the full IPCC assessment reports, provides vastly more information and linkages to a much wider set of reference materials (see http://www.aip.org/history/climate).

Optimal design of piezoelectric transformers: a rational approach based on an analytical model and a deterministic global optimization.

PubMed

Pigache, Francois; Messine, Frédéric; Nogarede, Bertrand

2007-07-01

This paper deals with a deterministic and rational way to design piezoelectric transformers in radial mode. The proposed approach is based on the study of the inverse problem of design and on its reformulation as a mixed constrained global optimization problem. The methodology relies on the association of the analytical models for describing the corresponding optimization problem and on an exact global optimization software, named IBBA and developed by the second author to solve it. Numerical experiments are presented and compared in order to validate the proposed approach.

Well-conditioning global-local analysis using stable generalized/extended finite element method for linear elastic fracture mechanics

NASA Astrophysics Data System (ADS)

Malekan, Mohammad; Barros, Felicio Bruzzi

2016-11-01

Using the locally-enriched strategy to enrich a small/local part of the problem by generalized/extended finite element method (G/XFEM) leads to non-optimal convergence rate and ill-conditioning system of equations due to presence of blending elements. The local enrichment can be chosen from polynomial, singular, branch or numerical types. The so-called stable version of G/XFEM method provides a well-conditioning approach when only singular functions are used in the blending elements. This paper combines numeric enrichment functions obtained from global-local G/XFEM method with the polynomial enrichment along with a well-conditioning approach, stable G/XFEM, in order to show the robustness and effectiveness of the approach. In global-local G/XFEM, the enrichment functions are constructed numerically from the solution of a local problem. Furthermore, several enrichment strategies are adopted along with the global-local enrichment. The results obtained with these enrichments strategies are discussed in detail, considering convergence rate in strain energy, growth rate of condition number, and computational processing. Numerical experiments show that using geometrical enrichment along with stable G/XFEM for global-local strategy improves the convergence rate and the conditioning of the problem. In addition, results shows that using polynomial enrichment for global problem simultaneously with global-local enrichments lead to ill-conditioned system matrices and bad convergence rate.

Guided color consistency optimization for image mosaicking

NASA Astrophysics Data System (ADS)

Xie, Renping; Xia, Menghan; Yao, Jian; Li, Li

2018-01-01

This paper studies the problem of color consistency correction for sequential images with diverse color characteristics. Existing algorithms try to adjust all images to minimize color differences among images under a unified energy framework, however, the results are prone to presenting a consistent but unnatural appearance when the color difference between images is large and diverse. In our approach, this problem is addressed effectively by providing a guided initial solution for the global consistency optimization, which avoids converging to a meaningless integrated solution. First of all, to obtain the reliable intensity correspondences in overlapping regions between image pairs, we creatively propose the histogram extreme point matching algorithm which is robust to image geometrical misalignment to some extents. In the absence of the extra reference information, the guided initial solution is learned from the major tone of the original images by searching some image subset as the reference, whose color characteristics will be transferred to the others via the paths of graph analysis. Thus, the final results via global adjustment will take on a consistent color similar to the appearance of the reference image subset. Several groups of convincing experiments on both the synthetic dataset and the challenging real ones sufficiently demonstrate that the proposed approach can achieve as good or even better results compared with the state-of-the-art approaches.

Global solutions to regional problems: Collecting global expertise to address the problem of harmful cyanobacterial blooms. A Lake Erie case study.

PubMed

Bullerjahn, George S; McKay, Robert M; Davis, Timothy W; Baker, David B; Boyer, Gregory L; D'Anglada, Lesley V; Doucette, Gregory J; Ho, Jeff C; Irwin, Elena G; Kling, Catherine L; Kudela, Raphael M; Kurmayer, Rainer; Michalak, Anna M; Ortiz, Joseph D; Otten, Timothy G; Paerl, Hans W; Qin, Boqiang; Sohngen, Brent L; Stumpf, Richard P; Visser, Petra M; Wilhelm, Steven W

2016-04-01

In early August 2014, the municipality of Toledo, OH (USA) issued a 'do not drink' advisory on their water supply directly affecting over 400,000 residential customers and hundreds of businesses (Wilson, 2014). This order was attributable to levels of microcystin, a potent liver toxin, which rose to 2.5μgL -1 in finished drinking water. The Toledo crisis afforded an opportunity to bring together scientists from around the world to share ideas regarding factors that contribute to bloom formation and toxigenicity, bloom and toxin detection as well as prevention and remediation of bloom events. These discussions took place at an NSF- and NOAA-sponsored workshop at Bowling Green State University on April 13 and 14, 2015. In all, more than 100 attendees from six countries and 15 US states gathered together to share their perspectives. The purpose of this review is to present the consensus summary of these issues that emerged from discussions at the Workshop. As additional reports in this special issue provide detailed reviews on many major CHAB species, this paper focuses on the general themes common to all blooms, such as bloom detection, modeling, nutrient loading, and strategies to reduce nutrients. Copyright © 2016 Elsevier B.V. All rights reserved.

Global solutions to regional problems: collecting global expertise to address the problem of harmful cyanobacterial blooms. A Lake Erie case study

PubMed Central

Bullerjahn, George S.; McKay, Robert M.; Davis, Timothy W.; Baker, David B.; Boyer, Gregory L.; D’Anglada, Lesley V.; Doucette, Gregory J.; Ho, Jeff C.; Irwin, Elena G.; Kling, Catherine L.; Kudela, Raphael M.; Kurmayer, Rainer; Michalak, Anna M.; Ortiz, Joseph D.; Otten, Timothy G.; Paerl, Hans W.; Qin, Boqiang; Sohngen, Brent L.; Stumpf, Richard P.; Visser, Petra M.; Wilhelm, Steven W.

2016-01-01

In early August 2014, the municipality of Toledo, OH (USA) issued a ‘do not drink’ advisory on their water supply directly affecting over 400,000 residential customers and hundreds of businesses (Wilson, 2014). This order was attributable to levels of microcystin, a potent liver toxin, which rose to 2.5 μg L-1 in finished drinking water. The Toledo crisis afforded an opportunity to bring together scientists from around the world to share ideas regarding factors that contribute to bloom formation and toxigenicity, bloom and toxin detection as well as prevention and remediation of bloom events. These discussions took place at an NSF- and NOAA-sponsored workshop at Bowling Green State University on April 13 and 14, 2015. In all, more than 100 attendees from six countries and 15 US states gathered together to share their perspectives. The purpose of this review is to present the consensus summary of these issues that emerged from discussions at the Workshop. As additional reports in this special issue provide detailed reviews on many major CHAB species, this paper focuses on the general themes common to all blooms, such as bloom detection, modeling, nutrient loading, and strategies to reduce nutrients. PMID:28073479

Ted Madden's Network Methods: Applications to the Earth's Schumann Resonances

NASA Astrophysics Data System (ADS)

Williams, E. R.; Yu, H.

2014-12-01

Ted Madden made clever use of electrical circuit concepts throughout his long career in geophysical research: induced polarization, DC resistivity, magnetotellurics, Schumann resonances, the transport properties of rocks and even elasticity and the brittle failure of stressed rocks. The general methods on network analogies were presented in a terse monograph (Madden, 1972) which came to be called "The Grey Peril" by his students, named more for the challenge of deciphering the material as for the color of its cover. This talk will focus on Ted's first major use of the transmission line analogy in treating the Earth's Schumann resonances. This approach in Madden and Thompson (1965) provided a greatly simplified two-dimensional treatment of an electromagnetic problem with a notable three-dimensional structure. This skillful treatment that included the role of the Earth's magnetic field also led to predictions that the Schumann resonance energy would leak into space, predictions that have been verified nearly 50 years later in satellite observations. An extension of the network analogy by Nelson (1967) using Green's function methods provides a means to treat the inverse problem for the background Schumann resonances for the global lightning activity. The development of Madden's methods will be discussed along with concrete results based on them for the monitoring of global lightning.

Addressing the Antibiotic Resistance Problem with Probiotics: Reducing the Risk of Its Double-Edged Sword Effect

PubMed Central

Imperial, Ivan C. V. J.; Ibana, Joyce A.

2016-01-01

Antibiotic resistance is a global public health problem that requires our attention. Indiscriminate antibiotic use is a major contributor in the introduction of selective pressures in our natural environments that have significantly contributed in the rapid emergence of antibiotic-resistant microbial strains. The use of probiotics in lieu of antibiotic therapy to address certain health conditions in both animals and humans may alleviate these antibiotic-mediated selective pressures. Probiotic use is defined as the actual application of live beneficial microbes to obtain a desired outcome by preventing diseased state or improving general health. Multiple studies have confirmed the beneficial effects of probiotic use in the health of both livestock and humans. As such, probiotics consumption is gaining popularity worldwide. However, concerns have been raised in the use of some probiotics strains that carry antibiotic resistance genes themselves, as they have the potential to pass the antibiotic resistance genes to pathogenic bacteria through horizontal gene transfer. Therefore, with the current public health concern on antibiotic resistance globally, in this review, we underscore the need to screen probiotic strains that are used in both livestock and human applications to assure their safety and mitigate their potential in significantly contributing to the spread of antibiotic resistance genes in our natural environments. PMID:28018315

Attributional styles in boys with severe behaviour problems: a possible reason for lack of progress on a positive behaviour programme.

PubMed

Eslea, M

1999-03-01

The number of exclusions from British schools has been increasing in recent years: the vast majority are because of disruptive behaviour. Increasing the effectiveness of behaviour control is therefore a priority for educators. This study tests the hypothesis that children who do not respond well to a behaviour modification regime exhibit a depressed attributional style. The sample comprised 26 boys aged 7-11 in a special day school for children with behaviour problems. Participants were interviewed about positive and negative aspects of school life: responses were coded using the Leeds Attributional Coding System (Stratton et al., 1988). School records were then used to identify children making good progress through the Positive Behaviour Programme (N = 13) and those making little or no progress (N = 8). Mean proportions of stable, global, internal, personal and controllable attributions were compared by progress group (high/low) and outcome (positive/negative) using mixed-design ANOVA. High progress children made significantly more global and internal attributions for positive than for negative events, while low progress children made more personal attributions for negative than for positive events. A depressed attributional style may act as a barrier which hinders the generalisation and internalisation of traditional behaviour modification methods. Increased teacher-awareness of attribution could increase the effectiveness of remedial programmes.

Risk assessment as rhetorical practice: The ironic mathematics behind terrorism, banking, and public policy.

PubMed

Danisch, Robert

2013-02-01

The twin problems of possible terrorist attacks and a global economic recession have been, and continue to be, critical components of contemporary political culture. At the center of both problems is the assessment of future risk. To calculate the probability that a loan will default or to estimate the likelihood of an act of bioterrorism crippling an American city is to engage in the quantitative science of risk assessment. The process of risk assessment is an attempt to rationalize the uncertainty and contingency of the future. In this essay, I read risk assessments made by the Department of Homeland Security and by major banks during the recent financial collapse as examples of rhetorical practice. As such, I show the rhetorical form and function of risk assessments in order to determine the effect that they have on contemporary political culture.

A New Approach to Data Publication in Ocean Sciences

NASA Astrophysics Data System (ADS)

Lowry, Roy; Urban, Ed; Pissierssens, Peter

2009-12-01

Data are collected from ocean sciences activities that range from a single investigator working in a laboratory to large teams of scientists cooperating on big, multinational, global ocean research projects. What these activities have in common is that all result in data, some of which are used as the basis for publications in peer-reviewed journals. However, two major problems regarding data remain. First, many data valuable for understanding ocean physics, chemistry, geology, biology, and how the oceans operate in the Earth system are never archived or made accessible to other scientists. Data underlying traditional journal articles are often difficult to obtain. Second, when scientists do contribute data to databases, their data become freely available, with little acknowledgment and no contribution to their career advancement. To address these problems, stronger ties must be made between data repositories and academic journals, and a “digital backbone” needs to be created for data related to journal publications.

Addiction: the urgent need for a paradigm shift.

PubMed

Alexander, Bruce K

2012-01-01

Severe addictions to drug use and to countless other habits are causing enormous harm around the globe. Massive expenditures and dedicated efforts of police, doctors, addiction therapists, and self-help groups have failed to bring the problem under control, although many individual addicts have been helped. What can society do when our best efforts continue to fail and a menacing problem continues to grow? This paper proposes that a major paradigm shift is required. The currently dominant paradigm assumes that addiction is either an individual disease or an individual moral breach. But this individually oriented paradigm has failed. Instead, addiction needs to be understood socially, as a way that large numbers of people adapt to the breakdown of psychologically sustaining culture under the global influence of free-market society. This new paradigm is based on the social thinking of Karl Polanyi and other social scientists rather than on the individual thinking of neuroscientists, doctors, or psychologists.

The mode branching route to localization of the finite-length floating elastica

NASA Astrophysics Data System (ADS)

Rivetti, Marco; Neukirch, Sébastien

2014-09-01

The beam on elastic foundation is a general model used in physical, biological, and technological problems to study delamination, wrinkling, or pattern formation. Recent focus has been given to the buckling of beams deposited on liquid baths, and in the regime where the beam is soft compared to hydrostatic forces the wrinkling pattern observed at buckling has been shown to lead to localization of the deformation when the confinement is increased. Here we perform a global study of the general case where the intensity of the liquid foundation and the confinement are both varied. We compute equilibrium and stability of the solutions and unravel secondary bifurcations that play a major role in the route to localization. Moreover we classify the post-buckling solutions and shed light on the mechanism leading to localization. Finally, using an asymptotic technique imported from fluid mechanics, we derive an approximated analytical solution to the problem.

Inherited haemoglobin disorders: an increasing global health problem.

PubMed Central

Weatherall, D. J.; Clegg, J. B.

2001-01-01

Despite major advances in our understanding of the molecular pathology, pathophysiology, and control and management of the inherited disorders of haemoglobin, thousands of infants and children with these diseases are dying through lack of appropriate medical care. This problem will undoubtedly increase over the next 20 years because, as the result of a reduction in childhood mortality due to infection and malnutrition, more babies with haemoglobin disorders will survive to present for treatment. Although WHO and various voluntary agencies have tried to disseminate information about these diseases, they are rarely mentioned as being sufficiently important to be included in setting health care priorities for the future. It takes considerable time to establish expertise in developing programmes for the control and management of these conditions, and the lessons learned in developed countries will need to be transmitted to those countries in which they occur at a high frequency. PMID:11545326

The recovery paradigm - a model of hope and change for alcohol and drug addiction.

PubMed

Best, David W; Lubman, Dan I

2012-08-01

Alcohol and drug disorders remain major health and social problems in Australia, contributing enormously to the global burden of disease and the everyday practice of primary care. A recent growth in recovery research and recovery focused policies are starting to have an impact in Australia, with implications for how we attempt to resolve these problems. In this article we discuss recent international findings in recovery research, and explore their implications for primary care. Research indicates that over half of dependent substance users will eventually achieve stable recovery. Key predictors of recovery are active engagement in the community and immersion in peer support groups and activities. Recovery requires a twin track approach: enabling and supporting individual recovery journeys, while creating environmental conditions that enable and support a 'social contagion' of recovery, in which recovery is transmitted through supportive social networks and dedicated recovery groups, such as mutual aid.

Combating the "other diseases" of MDG 6: changing the paradigm to achieve equity and poverty reduction?

PubMed

Molyneux, David H

2008-06-01

This paper suggests that the 'other diseases' of Millennium Development Goal 6 (MDG 6) are ignored by policy-makers and politicians who overfocus on unachievable objectives and targets around the 'big three' diseases of HIV, tuberculosis (TB) and malaria, which if the planet was viewed by aliens would be seen as the only diseases that existed on the planet. The diseases of the majority of the poor represent 'low hanging fruit' for control and elimination and opportunities are ignored despite the availability of cheap or donated drugs and ample evidence that such interventions are effective and reduce incidence, as well as mortality and morbidity. The time frame available to achieve the MDGs of some 7-8 years requires a re-evaluation of what can be done with the tools available now and which can address the problems faced by the majority of poor people afflicted by disabling conditions which together represent a global burden greater than malaria or TB. The author considers also the volume of research relevant to the MDGs and their achievement is distorted by the focus on high tech end research which cannot be delivered by 2015 and that in terms of the 90:10 gap in research relevant to the problems of the poorest the real gap is 99:1. The concepts of distortion of donor funding for diseases of MDG 6 for implementation of largely curative interventions which do not reduce incidence as well as research which addresses problems that cannot reach poor people in the time frame to 2015 is emphasised. New paradigms are required if any impact on MDG 6 is to be achieved recognising the needs of the majority via an equitable distribution of funding.

Computer vision syndrome prevalence, knowledge and associated factors among Saudi Arabia University Students: Is it a serious problem?

PubMed

Al Rashidi, Sultan H; Alhumaidan, H

2017-01-01

Computers and other visual display devices are now an essential part of our daily life. With the increased use, a very large population is experiencing sundry ocular symptoms globally such as dry eyes, eye strain, irritation, and redness of the eyes to name a few. Collectively, all such computer related symptoms are usually referred to as computer vision syndrome (CVS). The current study aims to define the prevalence, knowledge in community, pathophysiology, factors associated, and prevention of CVS. This is a cross-sectional study conducted in Qassim University College of Medicine during a period of 1 year from January 2015 to January 2016 using a questionnaire to collect relevant data including demographics and various variables to be studied. 634 students were inducted from a public sector University of Qassim, Saudi Arabia, regardless of their age and gender. The data were then statistically analyzed on SPSS version 22, and the descriptive data were expressed as percentages, mode, and median using graphs where needed. A total of 634 students with a mean age of 21. 40, Std 1.997 and Range 7 (18-25) were included as study subjects with a male predominance (77.28%). Of the total patients, majority (459, 72%) presented with acute symptoms while remaining had chronic problems. A clear-cut majority was carrying the symptoms for <5 days and >1 month. The statistical analysis revealed serious symptoms in the majority of study subjects especially those who are permanent users of a computer for long hours. Continuous use of computers for long hours is found to have severe problems of vision especially in those who are using computers and similar devices for a long duration.

Computer vision syndrome prevalence, knowledge and associated factors among Saudi Arabia University Students: Is it a serious problem?

PubMed Central

Al Rashidi, Sultan H.; Alhumaidan, H.

2017-01-01

Objectives: Computers and other visual display devices are now an essential part of our daily life. With the increased use, a very large population is experiencing sundry ocular symptoms globally such as dry eyes, eye strain, irritation, and redness of the eyes to name a few. Collectively, all such computer related symptoms are usually referred to as computer vision syndrome (CVS). The current study aims to define the prevalence, knowledge in community, pathophysiology, factors associated, and prevention of CVS. Methods: This is a cross-sectional study conducted in Qassim University College of Medicine during a period of 1 year from January 2015 to January 2016 using a questionnaire to collect relevant data including demographics and various variables to be studied. 634 students were inducted from a public sector University of Qassim, Saudi Arabia, regardless of their age and gender. The data were then statistically analyzed on SPSS version 22, and the descriptive data were expressed as percentages, mode, and median using graphs where needed. Results: A total of 634 students with a mean age of 21. 40, Std 1.997 and Range 7 (18-25) were included as study subjects with a male predominance (77.28%). Of the total patients, majority (459, 72%) presented with acute symptoms while remaining had chronic problems. A clear-cut majority was carrying the symptoms for <5 days and >1 month. The statistical analysis revealed serious symptoms in the majority of study subjects especially those who are permanent users of a computer for long hours. Conclusion: Continuous use of computers for long hours is found to have severe problems of vision especially in those who are using computers and similar devices for a long duration. PMID:29114189

Flow of Funds Modeling for Localized Financial Markets: An Application of Spatial Price and Allocation Activity Analysis Models.

DTIC Science & Technology

1981-01-01

on modeling the managerial aspects of the firm. The second has been the application to economic theory led by ...individual portfolio optimization problems which were embedded in a larger global optimization problem. In the global problem, portfolios were linked by market ...demand quantities or be given by linear demand relationships. As in~ the source markets , the model

Medicalization of global health 3: the medicalization of the non-communicable diseases agenda

PubMed Central

Clark, Jocalyn

2014-01-01

There is growing recognition of the massive global burden of non-communicable diseases (NCDs) due to their prevalence, projected social and economic costs, and traditional neglect compared to infectious disease. The 2011 UN Summit, WHO 25×25 targets, and support of major medical and advocacy organisations have propelled prominence of NCDs on the global health agenda. NCDs are by definition ‘diseases’ so already medicalized. But their social drivers and impacts are acknowledged, which demand a broad, whole-of-society approach. However, while both individual- and population-level targets are identified in the current NCD action plans, most recommended strategies tend towards the individualistic approach and do not address root causes of the NCD problem. These so-called population strategies risk being reduced to expectations of individual and behavioural change, which may have limited success and impact and deflect attention away from government policies or regulation of industry. Industry involvement in NCD agenda-setting props up a medicalized approach to NCDs: food and drink companies favour focus on individual choice and responsibility, and pharmaceutical and device companies favour calls for expanded access to medicines and treatment coverage. Current NCD framing creates expanded roles for physicians, healthcare workers, medicines and medical monitoring. The professional rather than the patient view dominates the NCD agenda and there is a lack of a broad, engaged, and independent NGO community. The challenge and opportunity lie in defining priorities and developing strategies that go beyond a narrow medicalized framing of the NCD problem and its solutions. PMID:24848661

From cigarette smuggling to illicit tobacco trade.

PubMed

Joossens, Luk; Raw, Martin

2012-03-01

Tax policy is considered the most effective strategy to reduce tobacco consumption and prevalence. Tax avoidance and tax evasion therefore undermine the effectiveness of tax policies and result in less revenue for governments, cheaper prices for smokers and increased tobacco use. Tobacco smuggling and illicit tobacco trade have probably always existed, since tobacco's introduction as a valuable product from the New World, but the nature of the trade has changed. This article clarifies definitions, reviews the key issues related to illicit trade, describes the different ways taxes are circumvented and looks at the size of the problem, its changing nature and its causes. The difficulties of data collection and research are discussed. Finally, we look at the policy options to combat illicit trade and the negotiations for a WHO Framework Convention on Tobacco Control (FCTC) protocol on illicit tobacco trade. Twenty years ago the main type of illicit trade was large-scale cigarette smuggling of well known cigarette brands. A change occurred as some major international tobacco companies in Europe and the Americas reviewed their export practices due to tax regulations, investigations and lawsuits by the authorities. Other types of illicit trade emerged such as illegal manufacturing, including counterfeiting and the emergence of new cigarette brands, produced in a rather open manner at well known locations, which are only or mainly intended for the illegal market of another country. The global scope and multifaceted nature of the illicit tobacco trade requires a coordinated international response, so a strong protocol to the FCTC is essential. The illicit tobacco trade is a global problem which needs a global solution.

Serum ferritin thresholds for the diagnosis of iron deficiency in pregnancy: a systematic review.

PubMed

Daru, J; Allotey, J; Peña-Rosas, J P; Khan, K S

2017-06-01

The aim of this review was to understand the landscape of serum ferritin in diagnosing iron deficiency in the aetiology of anaemia in pregnancy. Iron deficiency in pregnancy is a major public health problem leading to the development of anaemia. Reducing the global prevalence of anaemia in women of reproductive age is a 2025 global nutrition target. Bone marrow aspiration is the gold standard test for iron deficiency but requires an invasive procedure; therefore, serum ferritin is the most clinically useful test. We undertook a systematic search of electronic databases and trial registers from inception to January 2016. Studies of iron or micronutrient supplementation in pregnancy with pre-defined serum ferritin thresholds were included. Two independent reviewers selected studies, extracted data and assessed quality. There were 76 relevant studies mainly of observational study design (57%). The most commonly used thresholds of serum ferritin for the diagnosis of iron deficiency were <12 and <15 ng mL -1 (68%). Most primary studies provided no justification for the choice of serum ferritin threshold used, but 25 studies (33%) used thresholds defined by expert consensus in a guideline development process. There were five studies (7%) using a serum ferritin threshold defining iron deficiency derived from primary studies of bone marrow aspiration. Unified international thresholds of iron deficiency for women throughout pregnancy are required for accurate assessments of the global disease burden and for evaluating effectiveness of interventions addressing this problem. © 2017 World Health Organization licensed by Transfusion Medicine published by John Wiley & Sons Ltd on behalf of British Blood Transfusion Society.

Globalization and English in Chinese Higher Education

ERIC Educational Resources Information Center

Chang, Junyue

2006-01-01

This paper sets China's education of English majors within the changing global and national context. It examines the impact of accelerating globalisation and the rise of global English, the adjustment of China's English language policy, the growth of the education of English majors and the challenges faced by this sector of education. To adapt to…

The statistical analysis of global climate change studies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hardin, J.W.

1992-01-01

The focus of this work is to contribute to the enhancement of the relationship between climatologists and statisticians. The analysis of global change data has been underway for many years by atmospheric scientists. Much of this analysis includes a heavy reliance on statistics and statistical inference. Some specific climatological analyses are presented and the dependence on statistics is documented before the analysis is undertaken. The first problem presented involves the fluctuation-dissipation theorem and its application to global climate models. This problem has a sound theoretical niche in the literature of both climate modeling and physics, but a statistical analysis inmore » which the data is obtained from the model to show graphically the relationship has not been undertaken. It is under this motivation that the author presents this problem. A second problem concerning the standard errors in estimating global temperatures is purely statistical in nature although very little materials exists for sampling on such a frame. This problem not only has climatological and statistical ramifications, but political ones as well. It is planned to use these results in a further analysis of global warming using actual data collected on the earth. In order to simplify the analysis of these problems, the development of a computer program, MISHA, is presented. This interactive program contains many of the routines, functions, graphics, and map projections needed by the climatologist in order to effectively enter the arena of data visualization.« less

Accurate construction of consensus genetic maps via integer linear programming.

PubMed

Wu, Yonghui; Close, Timothy J; Lonardi, Stefano

2011-01-01

We study the problem of merging genetic maps, when the individual genetic maps are given as directed acyclic graphs. The computational problem is to build a consensus map, which is a directed graph that includes and is consistent with all (or, the vast majority of) the markers in the input maps. However, when markers in the individual maps have ordering conflicts, the resulting consensus map will contain cycles. Here, we formulate the problem of resolving cycles in the context of a parsimonious paradigm that takes into account two types of errors that may be present in the input maps, namely, local reshuffles and global displacements. The resulting combinatorial optimization problem is, in turn, expressed as an integer linear program. A fast approximation algorithm is proposed, and an additional speedup heuristic is developed. Our algorithms were implemented in a software tool named MERGEMAP which is freely available for academic use. An extensive set of experiments shows that MERGEMAP consistently outperforms JOINMAP, which is the most popular tool currently available for this task, both in terms of accuracy and running time. MERGEMAP is available for download at http://www.cs.ucr.edu/~yonghui/mgmap.html.

Inverse problems in complex material design: Applications to non-crystalline solids

NASA Astrophysics Data System (ADS)

Biswas, Parthapratim; Drabold, David; Elliott, Stephen

The design of complex amorphous materials is one of the fundamental problems in disordered condensed-matter science. While impressive developments of ab-initio simulation methods during the past several decades have brought tremendous success in understanding materials property from micro- to mesoscopic length scales, a major drawback is that they fail to incorporate existing knowledge of the materials in simulation methodologies. Since an essential feature of materials design is the synergy between experiment and theory, a properly developed approach to design materials should be able to exploit all available knowledge of the materials from measured experimental data. In this talk, we will address the design of complex disordered materials as an inverse problem involving experimental data and available empirical information. We show that the problem can be posed as a multi-objective non-convex optimization program, which can be addressed using a number of recently-developed bio-inspired global optimization techniques. In particular, we will discuss how a population-based stochastic search procedure can be used to determine the structure of non-crystalline solids (e.g. a-SiH, a-SiO2, amorphous graphene, and Fe and Ni clusters). The work is partially supported by NSF under Grant Nos. DMR 1507166 and 1507670.

Securing global trade through secure freight transportation : final report.

DOT National Transportation Integrated Search

2009-12-16

Given the increased probability of disruptions to global supply chains, and the significant impact these have on national and global economies, the problem is how to secure global trade. The concept of a global trade chain-of-custody has been develop...

A Worldwide Plan to Eliminate Global Warming, Air Pollution, and Energy Instability With Wind, Water, and Sunlight (WWS)

NASA Astrophysics Data System (ADS)

Jacobson, M. Z.; Delucchi, M. A.

2011-12-01

Global warming, air pollution mortality, and energy insecurity are three of the most significant problems facing the world today. This talk discusses a plan to solve the problems by powering 100% of the world's energy for all purposes, including electricity, transportation, industrial processes, and heating/cooling, with wind, water, and sunlight (WWS) within the next 20-40 years. It reviews and ranks major proposed energy solutions to global warming, air pollution mortality, and energy insecurity while considering other impacts of the proposed solutions, such as on water supply, land use, resource availability, reliability, wildlife, and catastrophic risk. It then evaluates a scenario for powering the world on the energy options determined to be the best while also considering materials, transmission infrastructure, costs, and politics. The study concludes that powering the world with WWS electric power technologies and a conversion from combustion to electricity and electrolytically-produced hydrogen is the cleanest and safest method of solving these problems. Due to the efficiency of electricity, such a conversion reduces world power demand by 30%. Methods of ensuring reliability of WWS electric power are available and will be demonstrated. We also conclude that neither liquid biofuels for transportation (including ethanol or biodiesel from any source), solid biofuels for home heating and cooking, biomass for electricity, conventional or fracked natural gas for electricity or transportation, nuclear power, nor coal with carbon capture (clean coal) are nearly so clean or safe as WWS technologies so are not recommended, either as bridge technologies or in the long term. Our plan calls for all new energy to be supplied by WWS-electricity-hydrogen resources no later than 2030 and all existing non-WWS infrastructure to be eliminated no later than 2050. We find that the plan is technically and economically feasible but politically challenging.

Scientific Visualization & Modeling for Earth Systems Science Education

NASA Technical Reports Server (NTRS)

Chaudhury, S. Raj; Rodriguez, Waldo J.

2003-01-01

Providing research experiences for undergraduate students in Earth Systems Science (ESS) poses several challenges at smaller academic institutions that might lack dedicated resources for this area of study. This paper describes the development of an innovative model that involves students with majors in diverse scientific disciplines in authentic ESS research. In studying global climate change, experts typically use scientific visualization techniques applied to remote sensing data collected by satellites. In particular, many problems related to environmental phenomena can be quantitatively addressed by investigations based on datasets related to the scientific endeavours such as the Earth Radiation Budget Experiment (ERBE). Working with data products stored at NASA's Distributed Active Archive Centers, visualization software specifically designed for students and an advanced, immersive Virtual Reality (VR) environment, students engage in guided research projects during a structured 6-week summer program. Over the 5-year span, this program has afforded the opportunity for students majoring in biology, chemistry, mathematics, computer science, physics, engineering and science education to work collaboratively in teams on research projects that emphasize the use of scientific visualization in studying the environment. Recently, a hands-on component has been added through science student partnerships with school-teachers in data collection and reporting for the GLOBE Program (GLobal Observations to Benefit the Environment).

Peatland hydrology and carbon release: why small-scale process matters.

PubMed

Holden, Joseph

2005-12-15

Peatlands cover over 400 million hectares of the Earth's surface and store between one-third and one-half of the world's soil carbon pool. The long-term ability of peatlands to absorb carbon dioxide from the atmosphere means that they play a major role in moderating global climate. Peatlands can also either attenuate or accentuate flooding. Changing climate or management can alter peatland hydrological processes and pathways for water movement across and below the peat surface. It is the movement of water in peats that drives carbon storage and flux. These small-scale processes can have global impacts through exacerbated terrestrial carbon release. This paper will describe advances in understanding environmental processes operating in peatlands. Recent (and future) advances in high-resolution topographic data collection and hydrological modelling provide an insight into the spatial impacts of land management and climate change in peatlands. Nevertheless, there are still some major challenges for future research. These include the problem that impacts of disturbance in peat can be irreversible, at least on human time-scales. This has implications for the perceived success and understanding of peatland restoration strategies. In some circumstances, peatland restoration may lead to exacerbated carbon loss. This will also be important if we decide to start to create peatlands in order to counter the threat from enhanced atmospheric carbon.

Use of cigarettes and other tobacco products among students aged 13-15 years--worldwide, 1999-2005.

PubMed

2006-05-26

The use of tobacco in any form is a major preventable cause of premature death and disease. Globally, nearly 5 million persons die every year from tobacco-related illnesses, with disproportionately higher mortality occurring in developing countries. The Global Youth Tobacco Survey (GYTS), initiated in 1999 by the World Health Organization (WHO), CDC, and the Canadian Public Health Association, is a school-based survey that includes questions on prevalence of cigarette and other tobacco use; attitudes toward tobacco; access to tobacco products; exposure to secondhand smoke, school curricula on tobacco, media, and advertising; and smoking cessation. This report presents estimates of self-reported cigarette and other tobacco-product use during 1999-2005 in 132 different countries and the Gaza Strip/West Bank. The data are aggregated within each of the six WHO regions. GYTS data indicate that nearly two of every 10 students reported currently using a tobacco product, with no statistically significant difference between the proportion of those reporting cigarette smoking (8.9%) and other tobacco use (11.2%). Use of tobacco by adolescents is a major public health problem in all six WHO regions. Worldwide, more countries need to develop, implement, and evaluate their tobacco-control programs to address the use of all types of tobacco products, especially among girls.

Major emerging and re-emerging zoonoses in China: a matter of global health and socioeconomic development for 1.3 billion.

PubMed

Liu, Quan; Cao, Lili; Zhu, Xing-Quan

2014-08-01

Emerging and re-emerging zoonoses are a significant public health concern and cause considerable socioeconomic problems globally. The emergence of severe acute respiratory syndrome (SARS), highly pathogenic avian influenza (HPAI) H5N1, avian influenza H7N9, and severe fever with thrombocytopenia syndrome (SFTS), and the re-emergence of rabies, brucellosis, and other zoonoses have had a significant effect on the national economy and public health in China, and have affected other countries. Contributing factors that continue to affect emerging and re-emerging zoonoses in China include social and environmental factors and microbial evolution, such as population growth, urbanization, deforestation, livestock production, food safety, climate change, and pathogen mutation. The Chinese government has devised new strategies and has taken measures to deal with the challenges of these diseases, including the issuing of laws and regulations, establishment of disease reporting systems, implementation of special projects for major infectious diseases, interdisciplinary and international cooperation, exotic disease surveillance, and health education. These strategies and measures can serve as models for the surveillance and response to continuing threats from emerging and re-emerging zoonoses in other countries. Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.

WATER CONSERVATION: LOCAL SOLUTIONS TO A GLOBAL PROBLEM

EPA Science Inventory

Water conservation issues are discussed. Local solutions to a global problem include changing old habits relating to the usage and abuse of water resources. While the suggested behavioral changes may not solve the world's pending water crisis, they may ease the impact of the l...

Magnetotail Reconnection

NASA Astrophysics Data System (ADS)

Petrukovich, A.; Artemyev, A.; Nakamura, R.

Reconnection is the key process responsible for the magnetotail dynamics. Driven reconnection in the distant tail is not sufficient to support global magnetospheric convection and the near Earth neutral line spontaneously forms to restore the balance. Mechanisms of initiation of such near-Earth magnetotail reconnection still represent one of major unresolved issues in space physics. We review the progress in this topic during the last decade. Recent theoretical advances suggest several variants of overcoming the famous tearing stability problem. Multipoint spacecraft observations reveal detailed structure of pre-onset current sheet of and reconnection zone down to ion larmor scale, supporting the importance of unstable state development through internal magnetotail reconfiguration.

Development of an economic skill building intervention to promote women's safety and child development in Karachi, Pakistan.

PubMed

Hirani, Saima Shams; Karmaliani, Rozina; McFarlane, Judith; Asad, Nargis; Madhani, Farhana; Shehzad, Shireen; Ali, Nazbano Ahmed

2010-02-01

Violence against women is a global epidemic phenomenon that can result in major mental health problems. Not only are women affected but also the health and well-being of their children are in jeopardy. To prevent violence and promote women's safety, several strategies have been tested in various cultural contexts. This article describes the process of developing and validating an economic skill building intervention for women of an urban slum area of Karachi, Pakistan. The purpose of the intervention is to increase women's economic independence, promote women's safety, and improve the behavioral functioning of their children.

Modeling of composite beams and plates for static and dynamic analysis

NASA Technical Reports Server (NTRS)

Hodges, Dewey H.; Atilgan, Ali R.; Lee, Bok Woo

1990-01-01

A rigorous theory and corresponding computational algorithms was developed for a variety of problems regarding the analysis of composite beams and plates. The modeling approach is intended to be applicable to both static and dynamic analysis of generally anisotropic, nonhomogeneous beams and plates. Development of a theory for analysis of the local deformation of plates was the major focus. Some work was performed on global deformation of beams. Because of the strong parallel between beams and plates, the two were treated together as thin bodies, especially in cases where it will clarify the meaning of certain terminology and the motivation behind certain mathematical operations.

Tuberculous meningoencephalitis.

PubMed

Muçaj, Sefedin; Dreshaj, Shemsedin; Kabashi, Serbeze; Hundozi, Hajrije; Gashi, Sanije; Zhjeqi, Valbona; Shala, Nexhmedin; Kryeziu, Manushaqe

2010-01-01

Tuberculous meningitis is an infection of the the membranes covering the brain and spinal cord (meninges). Tuberculous meningitis is a major global health problem and is the most severe form of extrapulmonary tuberculosis, with high rate mortality. Last years in Kosovo incidence of TB was decreased in less than 1000 cases per year and 10-20 cases per year of TB meningoencephalitis. Still Kosovo has limited numbers of TB. TBM is diagnosed on the basis of clinical features, cerebrospinal fluid (CSF) studies, and radiological findings. Clinical picture, neurological status, anamnestic data, suspect (but not specific) lab tests, and imaging new methods, together can give very valuable help to clinicians for early adequate and successful treatment.

Tropical medicine: Telecommunications and technology transfer

NASA Technical Reports Server (NTRS)

Legters, Llewellyn J.

1991-01-01

The potential for global outbreaks of tropical infectious diseases, and our ability to identify and respond to such outbreaks is a major concern. Rapid, efficient telecommunications is viewed as part of the solution to this set of problems - the means to link a network of epidemiological field stations via satellite with U.S. academic institutions and government agencies, for purposes of research, training in tropical medicine, and observation of and response to epidemic emergencies. At a workshop, telecommunications and technology transfer were addressed and applications of telecommunications technology in long-distance consultation, teaching and disaster relief were demonstrated. Applications in teaching and consultation in tropical infectious diseases is discussed.

State of the art on food allergen immunotherapy: oral, sublingual, and epicutaneous.

PubMed

Jones, Stacie M; Burks, A Wesley; Dupont, Christophe

2014-02-01

IgE-mediated food allergy is a global health problem that affects millions of persons and affects every aspect of life for the patient. Developing effective treatment strategies to augment current practice standards of strict dietary avoidance of antigens and availability of self-injectable epinephrine has been a major focus of research teams, advocacy groups, funding agencies, and patients and their families. Significant progress has been made through the development of allergen-specific immunotherapy encompassing 3 major forms of treatment: oral, sublingual, and epicutaneous immunotherapy. These therapies are in various stages of clinical investigation, with some successes noted in clinical outcomes and modulation of immune mechanisms toward effective therapy. Here we review recent progress and areas of concern for the role of these forms of immunotherapy as an emerging treatment for food allergy. Copyright © 2014 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.

Recent developments in fast spectroscopy for plant mineral analysis

PubMed Central

van Maarschalkerweerd, Marie; Husted, Søren

2015-01-01

Ideal fertilizer management to optimize plant productivity and quality is more relevant than ever, as global food demands increase along with the rapidly growing world population. At the same time, sub-optimal or excessive use of fertilizers leads to severe environmental damage in areas of intensive crop production. The approaches of soil and plant mineral analysis are briefly compared and discussed here, and the new techniques using fast spectroscopy that offer cheap, rapid, and easy-to-use analysis of plant nutritional status are reviewed. The majority of these methods use vibrational spectroscopy, such as visual-near infrared and to a lesser extent ultraviolet and mid-infrared spectroscopy. Advantages of and problems with application of these techniques are thoroughly discussed. Spectroscopic techniques considered having major potential for plant mineral analysis, such as chlorophyll a fluorescence, X-ray fluorescence, and laser-induced breakdown spectroscopy are also described. PMID:25852719

Obesity and Cardiometabolic Defects in Heart Failure Pathology.

PubMed

Halade, Ganesh V; Kain, Vasundhara

2017-09-12

Obesity is a major global epidemic that sets the stage for diverse multiple pathologies, including cardiovascular disease. The obesity-related low-grade chronic inflamed milieu is more pronounced in aging and responsive to cardiac dysfunction in heart failure pathology. Metabolic dysregulation of obesity integrates with immune reservoir in spleen and kidney network. Therefore, an integrative systems biology approach is necessary to delay progressive cardiac alternations. The purpose of this comprehensive review is to largely discuss the impact of obesity on the cardiovascular pathobiology in the context of problems and challenges, with major emphasis on the diversified models, and to study cardiac remodeling in obesity. The information in this article is immensely helpful in teaching advanced undergraduate, graduate, and medical students about the advancement and impact of obesity on cardiovascular health. © 2017 American Physiological Society. Compr Physiol 7:1463-1477, 2017. Copyright © 2017 John Wiley & Sons, Inc.

Adulteration and Counterfeiting of Online Nutraceutical Formulations in the United States: Time for Intervention?

PubMed

Nounou, Mohamed Ismail; Ko, Yamin; Helal, Nada A; Boltz, Jeremy F

2017-10-11

Global prevalence of nutraceuticals is noticeably high. The American market is flooded with nutraceuticals claiming to be of natural origin and sold with a therapeutic claim by major online retail stores such as Amazon and eBay. The objective of this commentary is to highlight the possible problems of online-sold nutraceuticals in the United States with respect to claim, adulterants, and safety. Furthermore, there is a lack of strict regulatory laws governing the sales, manufacturing, marketing, and label claims of nutraceutical formulations currently sold in the U.S. market. Major online retail stores and Internet pharmacies aid the widespread sale of nutraceuticals. Finally, according to the literature, many of these products were found to be either counterfeit or adulterated with active pharmaceutical ingredients (API) and mislabeled as being safe and natural. Therefore, regulatory authorities along with the research community should intervene to draw attention to these products and their possible effects.

[Meningococcal vaccines. Global epidemiological situation and strategies for prevention by vaccination].

PubMed

Rivero Calle, Irene; Rodriguez-Tenreiro Sánchez, Carmen; Martinón-Torres, Federico

2015-04-01

N. meningitidis is a major cause of meningitis and septicemia and a major public health problem in many countries. The disease, that can be fulminant, has a high mortality and may cause serious sequelae, even in cases of apparently optimal medical treatment. Chemoprophylaxis may prevent secondary cases among those in close contact with the ill, but, since secondary cases represent only 1%-2% of all meningococcal disease, chemoprophylaxis has a small impact when fighting most of endemic and epidemic forms. Given that al least 5% -15% of children and young adults are carriers, the fight against meningococcal disease based on chemotherapeutic elimination of nasopharyngeal colonization is virtually impossible. Therefore, immunization is the only rational way to combat this disease. Copyright © 2015 Elsevier España, S.L.U. y Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. All rights reserved.

Urbanisation and greening of Indian cities: Problems, practices, and policies.

PubMed

Imam, Aabshar U K; Banerjee, Uttam Kumar

2016-05-01

Progress of the Indian economy is threatened by the impact of climate change. Generation of urban heat islands (UHIs), waning of urban green cover, increase in carbon emissions and air pollution deteriorate the living environment. Rise in urban temperatures and heat stress induced mortality remain major concerns. Although the National Action Plan on Climate Change emphasises the national missions of 'enhanced energy efficiency', and 'green India', little research has been devoted to explore the passive cooling potential of urban greenery in India, thus lending uniqueness to this study. The manifestations of unplanned urban development (UHIs, escalated carbon emissions, air pollution) are discussed and corroborated with identification of contributory factors. Contemporary greening practices and bye-laws in four major Indian cities (New Delhi, Pune, Chennai, and Visakhapatnam) are analysed and compared with global best practices. The findings are used to propose planning guidelines which are expected to assist in consolidating natural sustainability of emerging economies.

Trojan Horse Antibiotics—A Novel Way to Circumvent Gram-Negative Bacterial Resistance?

PubMed Central

Tillotson, Glenn S.

2016-01-01

Antibiotic resistance has been emerged as a major global health problem. In particular, gram-negative species pose a significant clinical challenge as bacteria develop or acquire more resistance mechanisms. Often, these bacteria possess multiple resistance mechanisms, thus nullifying most of the major classes of drugs. Novel approaches to this issue are urgently required. However, the challenges of developing new agents are immense. Introducing novel agents is fraught with hurdles, thus adapting known antibiotic classes by altering their chemical structure could be a way forward. A chemical addition to existing antibiotics known as a siderophore could be a solution to the gram-negative resistance issue. Siderophore molecules rely on the bacterial innate need for iron ions and thus can utilize a Trojan Horse approach to gain access to the bacterial cell. The current approaches to using this potential method are reviewed. PMID:27773991

Trojan Horse Antibiotics-A Novel Way to Circumvent Gram-Negative Bacterial Resistance?

PubMed

Tillotson, Glenn S

2016-01-01

Antibiotic resistance has been emerged as a major global health problem. In particular, gram-negative species pose a significant clinical challenge as bacteria develop or acquire more resistance mechanisms. Often, these bacteria possess multiple resistance mechanisms, thus nullifying most of the major classes of drugs. Novel approaches to this issue are urgently required. However, the challenges of developing new agents are immense. Introducing novel agents is fraught with hurdles, thus adapting known antibiotic classes by altering their chemical structure could be a way forward. A chemical addition to existing antibiotics known as a siderophore could be a solution to the gram-negative resistance issue. Siderophore molecules rely on the bacterial innate need for iron ions and thus can utilize a Trojan Horse approach to gain access to the bacterial cell. The current approaches to using this potential method are reviewed.

Impacts of El Nino Southern Oscillation on the Global Yields of Major Crops

NASA Technical Reports Server (NTRS)

Iizumi, Toshichika; Luo, Jing-Jia; Challinor, Andrew J.; Sakurai, Gen; Yokozawa, Masayuki; Sakuma, Hirofumi; Brown, Molly Elizabeth; Yamagata, Toshio

2014-01-01

The monitoring and prediction of climate-induced variations in crop yields, production and export prices in major food-producing regions have become important to enable national governments in import-dependent countries to ensure supplies of affordable food for consumers. Although the El Nino/Southern Oscillation (ENSO) often affects seasonal temperature and precipitation, and thus crop yields in many regions, the overall impacts of ENSO on global yields are uncertain. Here we present a global map of the impacts of ENSO on the yields of major crops and quantify its impacts on their global-mean yield anomalies. Results show that El Nino likely improves the global-mean soybean yield by 2.15.4 but appears to change the yields of maize, rice and wheat by -4.3 to +0.8. The global-mean yields of all four crops during La Nina years tend to be below normal (-4.5 to 0.0).Our findings highlight the importance of ENSO to global crop production.

The Ground Flash Fraction Retrieval Algorithm Employing Differential Evolution: Simulations and Applications

NASA Technical Reports Server (NTRS)

Koshak, William; Solakiewicz, Richard

2012-01-01

The ability to estimate the fraction of ground flashes in a set of flashes observed by a satellite lightning imager, such as the future GOES-R Geostationary Lightning Mapper (GLM), would likely improve operational and scientific applications (e.g., severe weather warnings, lightning nitrogen oxides studies, and global electric circuit analyses). A Bayesian inversion method, called the Ground Flash Fraction Retrieval Algorithm (GoFFRA), was recently developed for estimating the ground flash fraction. The method uses a constrained mixed exponential distribution model to describe a particular lightning optical measurement called the Maximum Group Area (MGA). To obtain the optimum model parameters (one of which is the desired ground flash fraction), a scalar function must be minimized. This minimization is difficult because of two problems: (1) Label Switching (LS), and (2) Parameter Identity Theft (PIT). The LS problem is well known in the literature on mixed exponential distributions, and the PIT problem was discovered in this study. Each problem occurs when one allows the numerical minimizer to freely roam through the parameter search space; this allows certain solution parameters to interchange roles which leads to fundamental ambiguities, and solution error. A major accomplishment of this study is that we have employed a state-of-the-art genetic-based global optimization algorithm called Differential Evolution (DE) that constrains the parameter search in such a way as to remove both the LS and PIT problems. To test the performance of the GoFFRA when DE is employed, we applied it to analyze simulated MGA datasets that we generated from known mixed exponential distributions. Moreover, we evaluated the GoFFRA/DE method by applying it to analyze actual MGAs derived from low-Earth orbiting lightning imaging sensor data; the actual MGA data were classified as either ground or cloud flash MGAs using National Lightning Detection Network[TM] (NLDN) data. Solution error plots are provided for both the simulations and actual data analyses.

Retrieval of tropospheric aerosol properties over land from visible and near-infrared spectral reflectance: Application over Maryland

NASA Astrophysics Data System (ADS)

Levy, Robert Carroll

Aerosols are major components of the Earth's global climate system, affecting the radiation budget and cloud processes of the atmosphere. When located near the surface, high concentrations lead to lowered visibility, increased health problems and generally reduced quality of life for the human population. Over the United States mid-Atlantic region, aerosol pollution is a problem mainly during the summer. Satellites, such as the MODerate Imaging Spectrometer (MODIS), from their vantage point above the atmosphere, provide unprecedented coverage of global and regional aerosols over land. During MODIS' eight-year operation, exhaustive data validation and analyses have shown how the algorithm should be improved. This dissertation describes the development of the 'second-generation' operational algorithm for retrieval of global tropospheric aerosol properties over dark land surfaces, from MODIS-observed spectral reflectance. New understanding about global aerosol properties, land surface reflectance characteristics, and radiative transfer properties were learned in the process. This new operational algorithm performs a simultaneous inversion of reflectance in two visible channels (0.47 and 0.66 mum) and one shortwave infrared channel (2.12 mum), thereby having increased sensitivity to coarse aerosol. Inversion of the three channels retrieves the aerosol optical depth (tau) at 0.55 mum, the percentage of non-dust (fine model) aerosol (eta) and the surface reflectance. This algorithm is applied globally, and retrieves tau that is highly correlated (y = 0.02 + 1.0x, R=0.9) with ground-based sunphotometer measurements. The new algorithm estimates the global, over-land, long-term averaged tau ˜ 0.21, a 25% reduction from previous MODIS estimates. This leads to reducing estimates of global, non-desert, over-land aerosol direct radiative effect (all aerosols) by 1.7 W·m-2 (0.5 W·m-2 over the entire globe), which significantly impacts assessment of aerosol direct radiative forcing (contribution from anthropogenic aerosols only). Over the U.S. mid-Atlantic region, validated retrievals of tau (an integrated column property) can help to estimate surface PM2.5 concentration, a monitored criteria air quality property. The 3-dimensional aerosol loading in the region is characterized using aircraft measurements and the Community Multi-scale Air Quality Model (CMAQ) model, leading to some convergence of observed quantities and modeled processes.

Dynamical behavior for the three-dimensional generalized Hasegawa-Mima equations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang Ruifeng; Guo Boling; Institute of Applied Physics and Computational Mathematics, P.O. Box 8009, Beijing 100088

2007-01-15

The long time behavior of solution of the three-dimensional generalized Hasegawa-Mima [Phys. Fluids 21, 87 (1978)] equations with dissipation term is considered. The global attractor problem of the three-dimensional generalized Hasegawa-Mima equations with periodic boundary condition was studied. Applying the method of uniform a priori estimates, the existence of global attractor of this problem was proven, and also the dimensions of the global attractor are estimated.

Walking the Filament of Feasibility: Global Optimization of Highly-Constrained, Multi-Modal Interplanetary Trajectories Using a Novel Stochastic Search Technique

NASA Technical Reports Server (NTRS)

Englander, Arnold C.; Englander, Jacob A.

2017-01-01

Interplanetary trajectory optimization problems are highly complex and are characterized by a large number of decision variables and equality and inequality constraints as well as many locally optimal solutions. Stochastic global search techniques, coupled with a large-scale NLP solver, have been shown to solve such problems but are inadequately robust when the problem constraints become very complex. In this work, we present a novel search algorithm that takes advantage of the fact that equality constraints effectively collapse the solution space to lower dimensionality. This new approach walks the filament'' of feasibility to efficiently find the global optimal solution.

A Memetic Algorithm for Global Optimization of Multimodal Nonseparable Problems.

PubMed

Zhang, Geng; Li, Yangmin

2016-06-01

It is a big challenging issue of avoiding falling into local optimum especially when facing high-dimensional nonseparable problems where the interdependencies among vector elements are unknown. In order to improve the performance of optimization algorithm, a novel memetic algorithm (MA) called cooperative particle swarm optimizer-modified harmony search (CPSO-MHS) is proposed in this paper, where the CPSO is used for local search and the MHS for global search. The CPSO, as a local search method, uses 1-D swarm to search each dimension separately and thus converges fast. Besides, it can obtain global optimum elements according to our experimental results and analyses. MHS implements the global search by recombining different vector elements and extracting global optimum elements. The interaction between local search and global search creates a set of local search zones, where global optimum elements reside within the search space. The CPSO-MHS algorithm is tested and compared with seven other optimization algorithms on a set of 28 standard benchmarks. Meanwhile, some MAs are also compared according to the results derived directly from their corresponding references. The experimental results demonstrate a good performance of the proposed CPSO-MHS algorithm in solving multimodal nonseparable problems.

Collective intelligence for control of distributed dynamical systems

NASA Astrophysics Data System (ADS)

Wolpert, D. H.; Wheeler, K. R.; Tumer, K.

2000-03-01

We consider the El Farol bar problem, also known as the minority game (W. B. Arthur, The American Economic Review, 84 (1994) 406; D. Challet and Y. C. Zhang, Physica A, 256 (1998) 514). We view it as an instance of the general problem of how to configure the nodal elements of a distributed dynamical system so that they do not "work at cross purposes", in that their collective dynamics avoids frustration and thereby achieves a provided global goal. We summarize a mathematical theory for such configuration applicable when (as in the bar problem) the global goal can be expressed as minimizing a global energy function and the nodes can be expressed as minimizers of local free energy functions. We show that a system designed with that theory performs nearly optimally for the bar problem.

Numerical analysis of a main crack interactions with micro-defects/inhomogeneities using two-scale generalized/extended finite element method

NASA Astrophysics Data System (ADS)

Malekan, Mohammad; Barros, Felício B.

2017-12-01

Generalized or extended finite element method (G/XFEM) models the crack by enriching functions of partition of unity type with discontinuous functions that represent well the physical behavior of the problem. However, this enrichment functions are not available for all problem types. Thus, one can use numerically-built (global-local) enrichment functions to have a better approximate procedure. This paper investigates the effects of micro-defects/inhomogeneities on a main crack behavior by modeling the micro-defects/inhomogeneities in the local problem using a two-scale G/XFEM. The global-local enrichment functions are influenced by the micro-defects/inhomogeneities from the local problem and thus change the approximate solution of the global problem with the main crack. This approach is presented in detail by solving three different linear elastic fracture mechanics problems for different cases: two plane stress and a Reissner-Mindlin plate problems. The numerical results obtained with the two-scale G/XFEM are compared with the reference solutions from the analytical, numerical solution using standard G/XFEM method and ABAQUS as well, and from the literature.

Regional Climate Simulation and Data Assimilation with Variable-Resolution GCMs

NASA Technical Reports Server (NTRS)

Fox-Rabinovitz, Michael S.

2002-01-01

Variable resolution GCMs using a global stretched grid (SG) with enhanced regional resolution over one or multiple areas of interest represents a viable new approach to regional climateklimate change and data assimilation studies and applications. The multiple areas of interest, at least one within each global quadrant, include the major global mountains and major global monsoonal circulations over North America, South America, India-China, and Australia. They also can include the polar domains, and the European and African regions. The SG-approach provides an efficient regional downscaling to mesoscales, and it is an ideal tool for representing consistent interactions of globaYlarge- and regionallmeso- scales while preserving the high quality of global circulation. Basically, the SG-GCM simulations are no different from those of the traditional uniform-grid GCM simulations besides using a variable-resolution grid. Several existing SG-GCMs developed by major centers and groups are briefly described. The major discussion is based on the GEOS (Goddard Earth Observing System) SG-GCM regional climate simulations.

Guidelines for research on drugged driving

PubMed Central

Walsh, J. Michael; Verstraete, Alain G.; Huestis, Marilyn A.; Mørland, Jørg

2009-01-01

Aim A major problem in assessing the true public health impact of drug-use on driving and overall traffic safety is that the variables being measured across studies vary significantly. In studies reported in a growing global literature, basic parameters assessed, analytical techniques and drugs tested are simply not comparable due to lack of standardization in the field. These shortcomings severely limit the value of this research to add knowledge to the field. A set of standards to harmonize research findings is sorely needed. This project was initiated by several international organizations to develop guidelines for research on drugged driving. Methods A September 2006 meeting of international experts discussed the harmonization of protocols for future research on drugged driving. The principal objective of the meeting was to develop a consensus report setting guidelines, standards, core data variables and other controls that would form the basis for future international research. A modified Delphi method was utilized to develop draft guidelines. Subsequently, these draft guidelines were posted on the internet for global review, and comments received were integrated into the final document. Results The Guidelines Document is divided into three major sections, each focusing upon different aspects of drugged driving research (e.g. roadside surveys, prevalence studies, hospital studies, fatality and crash investigations, etc.) within the critical issue areas of ‘behavior’, ‘epidemiology’ and ‘toxicology’. The behavioral section contains 32 specific recommendations; (2) epidemiology 40 recommendations; and (3) toxicology 64 recommendations. Conclusions It is anticipated that these guidelines will improve significantly the overall quality of drugged driving research and facilitate future cross-study comparisons nationally and globally. PMID:18855814

Number of People Blind or Visually Impaired by Cataract Worldwide and in World Regions, 1990 to 2010.

PubMed

Khairallah, Moncef; Kahloun, Rim; Bourne, Rupert; Limburg, Hans; Flaxman, Seth R; Jonas, Jost B; Keeffe, Jill; Leasher, Janet; Naidoo, Kovin; Pesudovs, Konrad; Price, Holly; White, Richard A; Wong, Tien Y; Resnikoff, Serge; Taylor, Hugh R

2015-10-01

To estimate prevalence and number of people visually impaired or blind due to cataract. Based on the Global Burden of Diseases Study 2010 and ongoing literature research, we examined how many people were affected by moderate to severe vision impairment (MSVI; presenting visual acuity <6/18, ≥3/60) and blindness (presenting visual acuity <3/60) due to cataract. In 2010, of overall 32.4 million blind and 191 million vision impaired, 10.8 million people were blind and 35.1 million were visually impaired due to cataract. Cataract caused worldwide 33.4% of all blindness in 2010, and 18.4% of all MSVI. These figures were lower in the high-income regions (<15%) and higher (>40%) in South and Southeast Asia and Oceania. From 1990 to 2010, the number of blind or visually impaired due to cataract decreased by 11.4% and by 20.2%, respectively; the age-standardized global prevalence of cataract-related blindness and MSVI reduced by 46% and 50%, respectively, and the worldwide crude prevalence of cataract-related blindness and MSVI reduced by 32% and 39%, respectively. The percentage of global blindness and MSVI caused by cataract decreased from 38.6% to 33.4%, and from 25.6% to 18.4%, respectively. This decrease took place in almost all world regions, except East Sub-Saharan Africa. In 2010, one in three blind people was blind due to cataract, and one of six visually impaired people was visually impaired due to cataract. Despite major improvements in terms of reduction of prevalence, cataract remains a major public health problem.

Computational methods for global/local analysis

NASA Technical Reports Server (NTRS)

Ransom, Jonathan B.; Mccleary, Susan L.; Aminpour, Mohammad A.; Knight, Norman F., Jr.

1992-01-01

Computational methods for global/local analysis of structures which include both uncoupled and coupled methods are described. In addition, global/local analysis methodology for automatic refinement of incompatible global and local finite element models is developed. Representative structural analysis problems are presented to demonstrate the global/local analysis methods.

A Multiyear Dataset of SSM/I-Derived Global Ocean Surface Turbulent Fluxes

NASA Technical Reports Server (NTRS)

Chou, Shu-Hsien; Shie, Chung-Lin; Atlas, Robert M.; Ardizzone, Joe; Nelkin, Eric; Einaudi, Franco (Technical Monitor)

2001-01-01

The surface turbulent fluxes of momentum, latent heat, and sensible heat over global oceans are essential to weather, climate and ocean problems. Evaporation is a key component of the hydrological cycle and the surface heat budget, while the wind stress is the major forcing for driving the oceanic circulation. The global air-sea fluxes of momentum, latent and sensible heat, radiation, and freshwater (precipitation-evaporation) are the forcing for driving oceanic circulation and, hence, are essential for understanding the general circulation of global oceans. The global air-sea fluxes are required for driving ocean models and validating coupled ocean-atmosphere global models. We have produced a 7.5-year (July 1987-December 1994) dataset of daily surface turbulent fluxes over the global oceans from the Special Sensor microwave/Imager (SSM/I) data. Daily turbulent fluxes were derived from daily data of SSM/I surface winds and specific humidity, National Centers for Environmental Prediction (NCEP) sea surface temperatures, and European Centre for Medium-Range Weather Forecasts (ECMWF) air-sea temperature differences, using a stability-dependent bulk scheme. The retrieved instantaneous surface air humidity (with a 25-km resolution) validated well with that of the collocated radiosonde observations over the global oceans. Furthermore, the retrieved daily wind stresses and latent heat fluxes were found to agree well with that of the in situ measurements (IMET buoy, RV Moana Wave, and RV Wecoma) in the western Pacific warm pool during the TOGA COARE intensive observing period (November 1992-February 1993). The global distributions of 1988-94 seasonal-mean turbulent fluxes will be presented. In addition, the global distributions of 1990-93 annual-means turbulent fluxes and input variables will be compared with those of UWM/COADS covering the same period. The latter is based on the COADS (comprehensive ocean-atmosphere data set) and is recognized to be one of the best climatological analyses of fluxes derived from ship observations.

Is research on soil erosion hazard and mitigation in the Global South still needed? (Alexander von Humbold Medal Lecture)

NASA Astrophysics Data System (ADS)

Poesen, Jean

2016-04-01

Soil erosion represents a geomorphological and geological hazard that may cause environmental damage (land degradation), property damage, loss of livelihoods and services as well as social and economic disruption. Erosion not only lowers the quality of our soils on site, resulting in a drastic reduction of their ecosystem functions that play a vital role in daily life, but causes also significant sediment-related problems off site. To curb soil erosion problems, a range of soil conservation techniques and strategies have been designed and are being applied. Worldwide, ca. 62 000 research papers on soil erosion and 116 000 on soil conservation have been published (Web of Science, Dec. 2015). The number of such papers dealing with the Global South represents less than 20 % of all papers, despite the fact that many regions in this part of the world face significant soil erosion problems, aggravated by a rapidly growing population and major environmental changes. Given the large number of research papers on this topic, one might therefore conclude that we now know almost everything about the various soil erosion processes and rates, their factors and consequences as well as their control so that little new knowledge can still be added to the vast amount of available information. We refute this conclusion by pointing to some major research gaps that still need to be addressed if we want to use our soils in a more sustainable way. More specifically the following topics need more research attention: 1) improved understanding of both natural and anthropogenic soil erosion processes and their interactions, 2) scaling up soil erosion processes and rates in space and time, and 3) innovative techniques and strategies to prevent or reduce erosion rates. This will be illustrated with case studies from the Global South. If future research focuses on these research gaps, we will 1) better understand processes and their interactions operating at a range of spatial and temporal scales, their rates as well as their on-site and off-site impacts, which is crucial for better targeting erosion control measures and which is academically spoken rewarding, and 2) we will also be in a better position to select the most appropriate and effective soil erosion control techniques and strategies which are badly needed for a sustainable use of our soils in the Anthropocene and for the improvement of environmental conditions worldwide.

Globalization, international law, and emerging infectious diseases.

PubMed Central

Fidler, D. P.

1996-01-01

The global nature of the threat posed by new and reemerging infectious diseases will require international cooperation in identifying, controlling, and preventing these diseases. Because of this need for international cooperation, international law will certainly play a role in the global strategy for the control of emerging diseases. Recognizing this fact, the World Health Organization has already proposed revising the International Health Regulations. This article examines some basic problems that the global campaign against emerging infectious diseases might face in applying international law to facilitate international cooperation. The international legal component of the global control strategy for these diseases needs careful attention because of problems inherent in international law, especially as it applies to emerging infections issues. PMID:8903206

A global picture of biological invasion threat on islands.

PubMed

Bellard, Céline; Rysman, Jean-François; Leroy, Boris; Claud, Chantal; Mace, Georgina M

2017-12-01

Biological invasions are among the main drivers of biodiversity losses. As threats from biological invasions increase, one of the most urgent tasks is to identify areas of high vulnerability. However, the lack of comprehensive information on the impacts of invasive alien species (IAS) is a problem especially on islands, where most of the recorded extinctions associated with IAS have occurred. Here we provide a global, network-oriented analysis of IAS on islands. Using network analysis, we structured 27,081 islands and 437 threatened vertebrates into 21 clusters, based on their profiles in term of invasiveness and shared vulnerabilities. These islands are mainly located in the Southern Hemisphere and many are in biodiversity hotspots. Some of the islands share similar characteristics regarding their connectivity that could be useful for understanding their response to invasive species. The major invaders found in these clusters of islands are feral cats, feral dogs, pigs and rats. Our analyses reveal those IAS that systematically act alone or in combination, and the pattern of shared IAS among threatened species, providing new information to implement effective eradication strategies. Combined with further local, contextual information this can contribute to global strategies to deal with IAS.

Global paradigm shift in medical education: issues of concern for Africa.

PubMed

Gukas, Isaac D

2007-11-01

When medical education became established in Africa, many curricula were adopted from the West so as to achieve comparable standards in training. Over the last half a century however, major global pedagogical shifts have occurred in medical education without African keeping pace. This article reviews key pedagogical changes and other innovations in medical education that have occurred over the last half a century as reported in the literature and identifies some of the issues that need to be addressed in Africa. Socioeconomic and political instability, failure to rapidly overcome the inertia for change by substituting the old curriculum with a more problem, system and student-based one and redefining the goals of medical education are some of the issues of concern for Africa, and its ability to keep up in the dynamic world of medical education. There are only few faculty and school managers with effective medical education backgrounds to initiate, evaluate and sustain these changes. African medical academics, national governments and the international community need to come together to assist Africa to rise up to these challenges to ensure attainment and sustenance of global standards in medical training.

Global Precipitation Measurement (GPM) and International Space Station (ISS) Coordination for CubeSat Deployments to Minimize Collision Risk

NASA Technical Reports Server (NTRS)

Pawloski, James H.; Aviles, Jorge; Myers, Ralph; Parris, Joshua; Corley, Bryan; Hehn, Garrett; Pascucci, Joseph

2016-01-01

The Global Precipitation Measurement Mission (GPM) is a joint U.S. and Japan mission to observe global precipitation, extending the Tropical Rainfall Measuring Mission (TRMM), which was launched by H-IIA from Tanegashima in Japan on February 28TH, 2014 directly into its 407km operational orbit. The International Space Station (ISS) is an international human research facility operated jointly by Russia and the USA from NASA's Johnson Space Center (JSC) in Houston Texas. Mission priorities lowered the operating altitude of ISS from 415km to 400km in early 2105, effectively placing both vehicles into the same orbital regime. The ISS has begun a program of deployments of cost effective CubeSats from the ISS that allow testing and validation of new technologies. With a major new asset flying at the same effective altitude as the ISS, CubeSat deployments became a serious threat to GPM and therefore a significant indirect threat to the ISS. This paper describes the specific problem of collision threat to GPM and risk to ISS CubeSat deployment and the process that was implemented to keep both missions safe from collision and maximize their project goals.

Unknown caller: can we effectively manage the announcement of discovery of extraterrestrial life?

NASA Astrophysics Data System (ADS)

Gartrelle, Gordon M.

2015-10-01

The definitive discovery of another form of life from beyond Earth will answer one of our most fundamental questions: Are we alone in the Universe? This announcement will be the most significant in history. It will have impact on every facet of our lives and affect everyone on Earth. Ensuring the announcement is handled properly represents an opportunity to unify government, industrial, and scientific resources to work together on a global scale issue. The purpose of the present paper is to understand whether we have the overall strategy, management structures and process disciplines in place on a global scale to handle an announcement of this magnitude. The research methodology included review and analysis of peer-reviewed work on the topic, publications from appropriate scientific and policy organizations, and public statements from several acknowledged experts in the field of astrobiology and extraterrestrial communications. The 1996 case of the announcement of possible life from Martian meteorite ALH84001 was also analysed. The findings of the paper are multiple deficiencies exist in the ability to manage this problem globally in an integrated fashion across borders, institutional boundaries, and through the media. High-level recommendations are offered to address major identified gaps.

The global epidemiology of waterpipe smoking

PubMed Central

Maziak, Wasim; Taleb, Ziyad Ben; Bahelah, Raed; Islam, Farahnaz; Jaber, Rana; Auf, Rehab; Salloum, Ramzi G

2015-01-01

Objectives In the past decade, waterpipe smoking (a.k.a. hookah, shisha, narghile) has become a global phenomenon. In this review, we provide an updated picture of the main epidemiological trends in waterpipe smoking globally. Data sources Peer-reviewed publications indexed in major biomedical databases between 2004 and 2014. Search keywords included a combination of: waterpipe, hookah, shisha along with epidemiology, patterns, prevalence and predictors. We also used different spellings of waterpipe terms commonly used. Study selection The focus was on studies with large representative samples, national data or high-quality reports that illuminated aspects of the epidemiology and trends in waterpipe smoking. Data extraction Multiple researchers extracted the data independently and collectively decided on the most important and pertinent studies to include in the review. Data synthesis Waterpipe smoking has become a global phenomenon among youth. The global waterpipe epidemic is likely driven by (1) the introduction of manufactured flavoured tobacco (Maassel); (2) the intersection between waterpipe's social dimension and thriving café culture; (3) the evolution of mass communication media; (4) the lack of regulatory/policy framework specific to the waterpipe. Waterpipe smoking is becoming the most popular tobacco use method among youth in the Middle East, and is quickly gaining popularity elsewhere. Important patterns of waterpipe smoking include the predominance among younger, male, high socioeconomic, and urban groups. Intermittent and social use are also noted patterns. Conclusions Waterpipe smoking has become a global public health problem. Developing surveillance, intervention and regulatory/policy frameworks specific to the waterpipe has become a public health priority. PMID:25298368

Global Public Leadership in a Technological Era

ERIC Educational Resources Information Center

Masciulli, Joseph

2011-01-01

Good (ethical and effective) global public leadership--by national politicians, intergovernmental and nongovernmental international organizational leaders, multinational corporate leaders, and technoscientists--will make a significant positive difference in our global system's capacity to solve contemporary and futuristic global problems. High…

Connecting Students and Policymakers through Science and Service-Learning

NASA Astrophysics Data System (ADS)

Szymanski, D. W.

2017-12-01

Successful collaborations in community science require the participation of non-scientists as advocates for the use of science in addressing complex problems. This is especially true, but particularly difficult, with respect to the wicked problems of sustainability. The complicated, unsolvable, and inherently political nature of challenges like climate change can provoke cynicism and apathy about the use of science. While science education is a critical part of preparing all students to address wicked problems, it is not sufficient. Non-scientists must also learn how to advocate for the role of science in policy solutions. Fortunately, the transdisciplinary nature of sustainability provides a venue for engaging all undergraduates in community science, regardless of major. I describe a model for involving non-science majors in a form of service-learning, where the pursuit of community science becomes a powerful pedagogical tool for civic engagement. Bentley University is one of the few stand-alone business schools in the United States and provides an ideal venue to test this model, given that 95% of Bentley's 4000 undergraduates major in a business discipline. The technology-focused business program is combined with an integrated arts & sciences curriculum and experiential learning opportunities though the nationally recognized Bentley Service-Learning and Civic Engagement Center. In addition to a required general education core that includes the natural sciences, students may opt to complete a second major in liberal studies with thematic concentrations like Earth, Environment, and Global Sustainability. In the course Science in Environmental Policy, students may apply to complete a service-learning project for an additional course credit. The smaller group of students then act as consultants, conducting research for a non-profit organization in the Washington, D.C. area involved in geoscience policy. At the end of the semester, students travel to D.C. and present their findings to the non-profit partner and make policy recommendations to legislators in Capitol Hill visits. The projects have been highly impactful as a form of community science, creating passionate science advocacy among non-majors, improving collaborations with community partners, and spurring action by federal policymakers.

Enhancing US-Japan Cooperation to Combat Antimicrobial Resistance

PubMed Central

2014-01-01

The Global Health Security Agenda (GHSA) is aimed at preventing, detecting, and responding to infectious disease threats. To move toward these goals, the United States has committed to partner with at least 30 countries around the world. One of the objectives of the GHSA includes “[p]reventing the emergence and spread of antimicrobial drug resistant organisms.” Antimicrobial resistance (AMR) has become a growing global health security problem, with inappropriate use of antimicrobial medications in humans and animals and a lack of new antimicrobial medications contributing to this problem. While AMR is a growing global concern, working on it regionally can make this multifaceted problem more manageable. The United States and Japan, both world leaders in the life sciences, are close allies that have established cooperative programs in medical research and global health that can be used to work on combating AMR and advance the GHSA. Although the United States and Japan have cooperated on health issues in the past, their cooperation on the growing problem of AMR has been limited. Their existing networks, cooperative programs, and close relationships can and should be used to work on combating this expanding problem. PMID:25470465

Learning and Development: A Global Perspective. Symposium Series 15.

ERIC Educational Resources Information Center

Thomas, Alan, Ed.; Ploman, Edward W., Ed.

Fourteen papers presented at the Global Learning Symposium examine the learning perspective and its relationship to problems of world development. The learning perspective is compared and contrasted with the education perspective to reflect the degree to which the distinction reveals new knowledge on existing problems. Papers and presenters are:…

Managing Global Problems.

ERIC Educational Resources Information Center

Stanley, C. Maxwell

The book examines the historical background of and accomplishments in seven global problem areas. It is hypothesized that effective management within today's framework is the only way to progress toward the political and economic order that is necessary to assure peace and security, justice, and human rights, and to improve the quality of life. It…

Electronic neural network for solving traveling salesman and similar global optimization problems

NASA Technical Reports Server (NTRS)

Thakoor, Anilkumar P. (Inventor); Moopenn, Alexander W. (Inventor); Duong, Tuan A. (Inventor); Eberhardt, Silvio P. (Inventor)

1993-01-01

This invention is a novel high-speed neural network based processor for solving the 'traveling salesman' and other global optimization problems. It comprises a novel hybrid architecture employing a binary synaptic array whose embodiment incorporates the fixed rules of the problem, such as the number of cities to be visited. The array is prompted by analog voltages representing variables such as distances. The processor incorporates two interconnected feedback networks, each of which solves part of the problem independently and simultaneously, yet which exchange information dynamically.

Partial differential equations constrained combinatorial optimization on an adiabatic quantum computer

NASA Astrophysics Data System (ADS)

Chandra, Rishabh

Partial differential equation-constrained combinatorial optimization (PDECCO) problems are a mixture of continuous and discrete optimization problems. PDECCO problems have discrete controls, but since the partial differential equations (PDE) are continuous, the optimization space is continuous as well. Such problems have several applications, such as gas/water network optimization, traffic optimization, micro-chip cooling optimization, etc. Currently, no efficient classical algorithm which guarantees a global minimum for PDECCO problems exists. A new mapping has been developed that transforms PDECCO problem, which only have linear PDEs as constraints, into quadratic unconstrained binary optimization (QUBO) problems that can be solved using an adiabatic quantum optimizer (AQO). The mapping is efficient, it scales polynomially with the size of the PDECCO problem, requires only one PDE solve to form the QUBO problem, and if the QUBO problem is solved correctly and efficiently on an AQO, guarantees a global optimal solution for the original PDECCO problem.

Saudi English-Major Undergraduates' Academic Writing Problems: A Taif University Perspective

ERIC Educational Resources Information Center

Al-Khairy, Mohamed Ali

2013-01-01

This study attempted to investigate Saudi English-major undergraduates studying at Taif University to identify a) the types of academic writing Saudi English-major undergraduates carry out at English departments, b) Saudi English-major undergraduates' writing problems, c) the reasons behind Saudi English-major undergraduates' writing problems and…

Now what do people know about global climate change? Survey studies of educated laypeople.

PubMed

Reynolds, Travis William; Bostrom, Ann; Read, Daniel; Morgan, M Granger

2010-10-01

In 1992, a mental-models-based survey in Pittsburgh, Pennsylvania, revealed that educated laypeople often conflated global climate change and stratospheric ozone depletion, and appeared relatively unaware of the role of anthropogenic carbon dioxide emissions in global warming. This study compares those survey results with 2009 data from a sample of similarly well-educated laypeople responding to the same survey instrument. Not surprisingly, following a decade of explosive attention to climate change in politics and in the mainstream media, survey respondents in 2009 showed higher awareness and comprehension of some climate change causes. Most notably, unlike those in 1992, 2009 respondents rarely mentioned ozone depletion as a cause of global warming. They were also far more likely to correctly volunteer energy use as a major cause of climate change; many in 2009 also cited natural processes and historical climatic cycles as key causes. When asked how to address the problem of climate change, while respondents in 1992 were unable to differentiate between general "good environmental practices" and actions specific to addressing climate change, respondents in 2009 have begun to appreciate the differences. Despite this, many individuals in 2009 still had incorrect beliefs about climate change, and still did not appear to fully appreciate key facts such as that global warming is primarily due to increased concentrations of carbon dioxide in the atmosphere, and the single most important source of this carbon dioxide is the combustion of fossil fuels. © 2010 Society for Risk Analysis.

Global Studies of Molecular Clouds in the Galaxy, The Magellanic Clouds, and M31

NASA Technical Reports Server (NTRS)

Thaddeus, Patrick

1999-01-01

Over the course of this grant we used various spacecraft surveys of the Galaxy and M31 in conjunction with our extensive CO spectral line surveys to address central problems in galactic structure and the astrophysics of molecular clouds. These problems included the nature of the molecular ring and its relation to the spiral arms and central bar, the cosmic ray distribution, the origin of the diffuse X-ray background, the distribution and properties of x-ray sources and supernova remnants, and the Galactic stellar mass distribution. For many of these problems, the nearby spiral M31 provided an important complementary perspective. Our CO surveys of GMCs (Galactic Molecular Clouds) were crucial for interpreting Galactic continuum surveys from satellites such as GRO (Gamma Ray Observatory), ROSAT (Roentgen Satellite), IRAS (Infrared Astronomy Satellite), and COBE (Cosmic Background Explorer Satellite) because they provided the missing dimension of velocity or kinematic distance. GMCs are a well-defined and widespread population of objects whose velocities we could readily measure throughout the Galaxy. Through various emission and absorption mechanisms involving their gas, dust, or associated Population I objects, GMCs modulate the galactic emission in virtually every major wavelength band. Furthermore, the visibility. of GMCs at so many wavelengths provided various methods of resolving the kinematic distance ambiguity for these objects in the inner Galaxy. Summaries of our accomplishments in each of the major wavelength bands discussed in our original proposal are given

Seeking Global Minima

NASA Astrophysics Data System (ADS)

Tajuddin, Wan Ahmad

1994-02-01

Ease in finding the configuration at the global energy minimum in a symmetric neural network is important for combinatorial optimization problems. We carry out a comprehensive survey of available strategies for seeking global minima by comparing their performances in the binary representation problem. We recall our previous comparison of steepest descent with analog dynamics, genetic hill-climbing, simulated diffusion, simulated annealing, threshold accepting and simulated tunneling. To this, we add comparisons to other strategies including taboo search and one with field-ordered updating.

Enhancing Polyhedral Relaxations for Global Optimization

ERIC Educational Resources Information Center

Bao, Xiaowei

2009-01-01

During the last decade, global optimization has attracted a lot of attention due to the increased practical need for obtaining global solutions and the success in solving many global optimization problems that were previously considered intractable. In general, the central question of global optimization is to find an optimal solution to a given…

Global Regularity for Several Incompressible Fluid Models with Partial Dissipation

NASA Astrophysics Data System (ADS)

Wu, Jiahong; Xu, Xiaojing; Ye, Zhuan

2017-09-01

This paper examines the global regularity problem on several 2D incompressible fluid models with partial dissipation. They are the surface quasi-geostrophic (SQG) equation, the 2D Euler equation and the 2D Boussinesq equations. These are well-known models in fluid mechanics and geophysics. The fundamental issue of whether or not they are globally well-posed has attracted enormous attention. The corresponding models with partial dissipation may arise in physical circumstances when the dissipation varies in different directions. We show that the SQG equation with either horizontal or vertical dissipation always has global solutions. This is in sharp contrast with the inviscid SQG equation for which the global regularity problem remains outstandingly open. Although the 2D Euler is globally well-posed for sufficiently smooth data, the associated equations with partial dissipation no longer conserve the vorticity and the global regularity is not trivial. We are able to prove the global regularity for two partially dissipated Euler equations. Several global bounds are also obtained for a partially dissipated Boussinesq system.

Chapter 6: New Products and Product Categories in the Global Forest Sector

Treesearch

Zhiyong Cai; Alan W. Rudie; Nicole M. Stark; Ronald C. Sabo; Sally A. Ralph

2013-01-01

Forests, covering about 30% of the earth’s land area, are a major component in the global ecosystem, influencing the carbon cycle, climate change, habitat protection, clean water supplies, and sustainable economies (FAO 2011). Globally, the vast cellulosic resource found in forests provides about half of all major industrial raw materials for renewable energy, chemical...

International News Flows in the Post-Cold War World: Mapping the News and the News Producers.

ERIC Educational Resources Information Center

Sreberny-Mohammadi, Annabelle

1995-01-01

Reviews the global political environment, major global news providers, and technologies of global news production. Argues for a multinational comparative mapping of international news representation in the 1990s. Outlines a major international venture to update and elaborate the 1979 UNESCO/IAMCR study of foreign news in the media of 29 countries,…

Programming of Fetal Insulin Resistance in Pregnancies with Maternal Obesity by ER Stress and Inflammation

PubMed Central

Sáez, Pablo J.; Villalobos-Labra, Roberto; Farías-Jofré, Marcelo

2014-01-01

The global epidemics of obesity during pregnancy and excessive gestational weight gain (GWG) are major public health problems worldwide. Obesity and excessive GWG are related to several maternal and fetal complications, including diabetes (pregestational and gestational diabetes) and intrauterine programming of insulin resistance (IR). Maternal obesity (MO) and neonatal IR are associated with long-term development of obesity, diabetes mellitus, and increased global cardiovascular risk in the offspring. Multiple mechanisms of insulin signaling pathway impairment have been described in obese individuals, involving complex interactions of chronically elevated inflammatory mediators, adipokines, and the critical role of the endoplasmic reticulum (ER) stress-dependent unfolded protein response (UPR). However, the underlying cellular processes linking MO and IR in the offspring have not been fully elucidated. Here, we summarize the state-of-the-art evidence supporting the possibility that adverse metabolic postnatal outcomes such as IR in the offspring of pregnancies with MO and/or excessive GWG may be related to intrauterine activation of ER stress response. PMID:25093191

Predictiveness of Disease Risk in a Global Outreach Tourist Setting in Thailand Using Meteorological Data and Vector-Borne Disease Incidences

PubMed Central

Ninphanomchai, Suwannapa; Chansang, Chitti; Hii, Yien Ling; Rocklöv, Joacim; Kittayapong, Pattamaporn

2014-01-01

Dengue and malaria are vector-borne diseases and major public health problems worldwide. Changes in climatic factors influence incidences of these diseases. The objective of this study was to investigate the relationship between vector-borne disease incidences and meteorological data, and hence to predict disease risk in a global outreach tourist setting. The retrospective data of dengue and malaria incidences together with local meteorological factors (temperature, rainfall, humidity) registered from 2001 to 2011 on Koh Chang, Thailand were used in this study. Seasonal distribution of disease incidences and its correlation with local climatic factors were analyzed. Seasonal patterns in disease transmission differed between dengue and malaria. Monthly meteorological data and reported disease incidences showed good predictive ability of disease transmission patterns. These findings provide a rational basis for identifying the predictive ability of local meteorological factors on disease incidence that may be useful for the implementation of disease prevention and vector control programs on the tourism island, where climatic factors fluctuate. PMID:25325356

Monitoring temporal and spatial trends of legacy and emerging contaminants in marine environment: results from the environmental specimen bank (es-BANK) of Ehime University, Japan.

PubMed

Tanabe, Shinsuke; Ramu, Karri

2012-07-01

The Environmental Specimen Bank (es-BANK) for Global Monitoring at the Center for Marine Environmental Studies, Ehime University, Japan has more than four decades of practical experience in specimen banking. Over the years, es-BANK has archived specimens representing a wide range of environmental matrices, i.e. fishes, reptiles, birds, aquatic mammals, terrestrial mammals, human, soils, and sediments. The samples have been collected as part of the various monitoring programs conducted worldwide. The current review is a summary of selected studies conducted at the Center for Marine Environmental Studies, on temporal and spatial trends of legacy and emerging contaminants in the marine environment. One of the major conclusions drawn from the studies is that environmental problems are no more regional issues and, thus, environmental specimen banking should not be limited to national boundaries, but should have a global outlook. Copyright © 2012 Elsevier Ltd. All rights reserved.

A new index to assess chemicals increasing the greenhouse effect based on their toxicity to algae.

PubMed

Wang, Ting; Zhang, Xiaoxian; Tian, Dayong; Gao, Ya; Lin, Zhifen; Liu, Ying; Kong, Lingyun

2015-11-01

CO2, as the typical greenhouse gas causing the greenhouse effect, is a major global environmental problem and has attracted increasing attention from governments. Using algae to eliminate CO2, which has been proposed as an effective way to reduce the greenhouse effect in the past decades, can be disturbed by a growing number of artificial chemicals. Thus, seven types of chemicals and Selenastrum capricornutum (algae) were examined in this study, and the good consistency between the toxicity of artificial chemicals to algae and the disturbance of carbon fixation by the chemicals was revealed. This consistency showed that the disturbance of an increasing number of artificial chemicals to the carbon fixation of algae might be a "malware" worsening the global greenhouse effect. Therefore, this study proposes an original, promising index to assess the risk of deepening the greenhouse effect by artificial chemicals before they are produced and marketed. Copyright © 2015 Elsevier B.V. All rights reserved.

[Multi-Scale Convergence of Cold-Land Process Representation in Land-Surface Models, Microwave Remote Sensing, and Field Observations

NASA Technical Reports Server (NTRS)

Shi, Jiancheng

2005-01-01

The cryosphere is a major component of the hydrosphere and interacts significantly with the global climate system, the geosphere, and the biosphere. Measurement of the amount of water stored in the snow pack and forecasting the rate of melt are thus essential for managing water supply and flood control systems. Snow hydrologists are confronted with the dual problems of estimating both the quantity of water held by seasonal snow packs and time of snow melt. Monitoring these snow parameters is essential for one of the objectives of the Earth Science Enterprise-understanding of the global hydrologic cycle. Measuring spatially distributed snow properties, such as snow water equivalence (SWE) and wetness, from space is a key component for improvement of our understanding of coupled atmosphere-surface processes. Through the GWEC project, we have significantly advanced our understandings and improved modeling capabilities of the microwave signatures in response to snow and underground properties.

Performance characteristics and modeling of carbon dioxide absorption by amines in a packed column

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lin, S.H.; Shyu, C.T.

1999-01-01

Carbon dioxide (CO[sub 2]) is widely recognized as a major greenhouse gas contributing to global warming. To mitigate the global warming problem, removal of CO[sub 2] from the industrial flue gases is necessary. Absorption of carbon dioxide by amines in a packed column was experimentally investigated. The amines employed in the present study were the primary mono-ethanolamine (MEA) and tertiary N-methyldiethanolamine (MDEA), two very popular amines widely used in the industries for gas purification. The CO[sub 2] absorption characteristics by these two amines were experimentally examined under various operating conditions. A theoretical model was developed for describing the CO[sub 2]more » absorption behavior. Test data have revealed that the model predictions and the observed CO[sub 2] absorption breakthrough curves agree very well, validating the proposed model. Preliminary regeneration tests of exhausted amine solution were also conducted. The results indicated that the tertiary amine is easier to regenerate with less loss of absorption capacity than the primary one.« less

The unregulated commercialization of stem cell treatments: a global perspective.

PubMed

Sipp, Douglas

2011-12-01

Research into the biological properties and clinical potential of stem cells has spurred strong public investment, industry development, media coverage, and patient interest in recent years. To date, however, few clinical applications of demonstrated safety and efficacy have been developed with the exception of uses of hematopoietic stem cells in the treatment of diseases of the blood and immune systems. This lack of an evidence basis notwithstanding, hundreds of companies and private clinics around the world now sell putative stem cell treatments for an enormously broad range of medical and quality-of-life conditions. This represents a major challenge for legitimate scientists working in the field, for authorities seeking to protect their constituencies, and for patients and consumers targeted by such companies' marketing strategies. In this review, I provide an overview of the global industry in pseudomedical stem cell treatments, with an investigation of claims in a single disease area (amyotrophic lateral sclerosis), and make recommendations for the introduction and enforcement of appropriate regulatory responses to this problem.

Predictiveness of disease risk in a global outreach tourist setting in Thailand using meteorological data and vector-borne disease incidences.

PubMed

Ninphanomchai, Suwannapa; Chansang, Chitti; Hii, Yien Ling; Rocklöv, Joacim; Kittayapong, Pattamaporn

2014-10-16

Dengue and malaria are vector-borne diseases and major public health problems worldwide. Changes in climatic factors influence incidences of these diseases. The objective of this study was to investigate the relationship between vector-borne disease incidences and meteorological data, and hence to predict disease risk in a global outreach tourist setting. The retrospective data of dengue and malaria incidences together with local meteorological factors (temperature, rainfall, humidity) registered from 2001 to 2011 on Koh Chang, Thailand were used in this study. Seasonal distribution of disease incidences and its correlation with local climatic factors were analyzed. Seasonal patterns in disease transmission differed between dengue and malaria. Monthly meteorological data and reported disease incidences showed good predictive ability of disease transmission patterns. These findings provide a rational basis for identifying the predictive ability of local meteorological factors on disease incidence that may be useful for the implementation of disease prevention and vector control programs on the tourism island, where climatic factors fluctuate.

Economic Impact of Food Safety Outbreaks on Food Businesses

PubMed Central

Hussain, Malik Altaf; Dawson, Christopher O.

2013-01-01

A globalized food trade, extensive production and complex supply chains are contributing toward an increased number of microbiological food safety outbreaks. Moreover, the volume of international food trade has increased to become very large. All of these factors are putting pressure on the food companies to meet global demand in order to be competitive. This scenario could force manufacturers to be lenient toward food safety control intentionally, or unintentionally, and result in a major foodborne outbreak that causes health problems and economic loss. The estimated cost of food safety incidents for the economy of the United States is around $7 billion per year which comes from notifying consumers, removing food from shelves, and paying damages as a result of lawsuits. Most other countries similarly have economic losses. Much of these losses represent lost markets, loss of consumer demand, litigation and company closures. Concrete steps are needed to improve safety of foods produced for local or overseas markets to avoid unexpected food scandals and economic losses. PMID:28239140

Priorities for research and control of cestode zoonoses in Asia

PubMed Central

2013-01-01

Globally, cestode zoonoses cause serious public health problems, particularly in Asia. Among all neglected zoonotic diseases, cestode zoonoses account for over 75% of global disability adjusted life years (DALYs) lost. An international symposium on cestode zoonoses research and control was held in Shanghai, China between 28th and 30th October 2012 in order to establish joint efforts to study and research effective approaches to control these zoonoses. It brought together 96 scientists from the Asian region and beyond to exchange ideas, report on progress, make a gap analysis, and distill prioritizing settings with a focus on the Asian region. Key objectives of this international symposium were to agree on solutions to accelerate progress towards decreasing transmission, and human mortality and morbidity caused by the three major cestode zoonoses (cystic echinococcosis, alveolar echinococcosis, and cysticercosis); to critically assess the potential to control these diseases; to establish a research and validation agenda on existing and new approaches; and to report on novel tools for the study and control of cestode zoonoses. PMID:23915395

Mobilization strategy to overcome global crisis of water consumption

NASA Astrophysics Data System (ADS)

Suzdaleva, Antonina; Goryunova, Svetlana; Marchuk, Aleksey; Borovkov, Valery

2017-10-01

Today, the global water consumption crisis is one of the main threats that can disrupt socio-economic and environmental conditions of life of the majority of the world’s population. The water consumption mobilization strategy is based on the idea of increasing the available water resources. The main direction for the implementation of this strategy is the construction of anti-rivers - the systems for inter-basin (interregional) water resources redistribution. Antirivers are intended for controlled redistribution of water resources from regions with their catastrophic excess to regions with their critical shortage. The creation of anti-rivers, taking into account the requirements of environmental safety, will form large-scale managed natural- engineering systems and implement the principle of sustainable development adopted by the United Nations. The aim of the article is to substantiate a new methodological approach to address the problem, where the implementation of this approach can prevent large-scale humanitarian and environmental disasters expected in the coming years.

A comprehensive mission to planet Earth: Woods Hole Space Science and Applications Advisory Committee Planning Workshop

NASA Technical Reports Server (NTRS)

1991-01-01

The NASA program Mission to Planet Earth (MTPE) is described in this set of visuals presented in Massachusetts on July 29, 1991. The problem presented in this document is that the earth system is changing and that human activity accelerates the rate of change resulting in increased greenhouse gases, decreasing levels of stratospheric ozone, acid rain, deforestation, decreasing biodiversity, and overpopulation. Various national and international organizations are coordinating global change research. The complementary space observations for this activity are sun-synchronous polar orbits, low-inclination, low altitude orbits, geostationary orbits, and ground measurements. The Geostationary Earth Observatory is the major proposed mission of MTPE. Other proposed missions are EOS Synthetic Aperture Radar, ARISTOTELES Magnetic Field Experiment, and the Global Topography Mission. Use of the NASA DC-8 aircraft is outlined as carrying out the Airborne Science and Applications Program. Approved Earth Probes Program include the Total Ozone Mapping Spectrometer (TOMS). Other packages for earth observation are described.

Oral Health Care for Children in Countries Using Dental Therapists in Public, School-Based Programs, Contrasted with That of the United States, Using Dentists in a Private Practice Model

PubMed Central

Friedman, Jay W.; Nash, David A.

2013-01-01

The United States faces a significant problem with access to oral health care, particularly for children. More than 50 countries have developed an alternative dental provider, a dental therapist, practicing in public, school-based programs, to address children’s access to care. This delivery model has been demonstrated to improve access to care and oral health outcomes while providing quality care economically. We summarize elements of a recent major review of the global literature on the use of dental therapists, “A Review of the Global Literature on Dental Therapists: In the Context of the Movement to Add Dental Therapists to the Oral Health Workforce in the United States.” We contrast the success of a school-based model of caring for children by dental therapists with that of the US model of dentists providing care for children in private practices. PMID:23865650

Multiple-stage ambiguity in motion perception reveals global computation of local motion directions.

PubMed

Rider, Andrew T; Nishida, Shin'ya; Johnston, Alan

2016-12-01

The motion of a 1D image feature, such as a line, seen through a small aperture, or the small receptive field of a neural motion sensor, is underconstrained, and it is not possible to derive the true motion direction from a single local measurement. This is referred to as the aperture problem. How the visual system solves the aperture problem is a fundamental question in visual motion research. In the estimation of motion vectors through integration of ambiguous local motion measurements at different positions, conventional theories assume that the object motion is a rigid translation, with motion signals sharing a common motion vector within the spatial region over which the aperture problem is solved. However, this strategy fails for global rotation. Here we show that the human visual system can estimate global rotation directly through spatial pooling of locally ambiguous measurements, without an intervening step that computes local motion vectors. We designed a novel ambiguous global flow stimulus, which is globally as well as locally ambiguous. The global ambiguity implies that the stimulus is simultaneously consistent with both a global rigid translation and an infinite number of global rigid rotations. By the standard view, the motion should always be seen as a global translation, but it appears to shift from translation to rotation as observers shift fixation. This finding indicates that the visual system can estimate local vectors using a global rotation constraint, and suggests that local motion ambiguity may not be resolved until consistencies with multiple global motion patterns are assessed.

Individual Responsibility for Promoting Global Health: The Case for a New Kind of Socially Conscious Consumption.

PubMed

Hassoun, Nicole

2016-06-01

The problems of global health are truly terrible. Millions suffer and die from diseases like tuberculosis, HIV/AIDS, and malaria. One way of addressing these problems is via a Global Health Impact labeling campaign (http://global-health-impact.org/). If even a small percentage of consumers promote global health by purchasing Global Health Impact products, the incentive to use this label will be substantial. One might wonder, however, whether consumers are morally obligation to purchase any these goods or whether doing so is even morally permissible. This paper suggests that if the proposal is implemented, purchasing Global Health Impact labelled goods is at least morally permissible, if not morally required. Its argument should, moreover, be of much more general interest to those considering different kinds of ethical consumption. © 2016 American Society of Law, Medicine & Ethics.

The factor of local cultural specificity and process of globalization.

PubMed

Rudnev, Viacheslav

2012-12-01

Cultural polymorphism is a difficult phenomenon, which has multiform influence on the society's life. The active interest of society to local folk knowledge in life-support activities and Nature using is one of the distinctive marks of modern time. This interest has fallen on the period of active transformations of environment as a result of industrial society's pressing on Nature, and the generating of new approaches in the studying of Nature and human activity based on the "technologies" of wild life. The success of humankind in creating artificial surroundings has led to both great success in improving the quality of peoples' lives, and also to problems with renewable resources and human health and to changing for the worse ecology. In 1992 the Unites Nations Conference on Environment and Development (Rio de Janeiro, Brazil) set fixed standards defining global violations of the environment. The zAgenda 21', adopted at this Conference, focused on the necessity of new solutions for problems of the relationships between Nature and Society, mentioning interdisciplinary research as a positive way to search for solutions to new problems, and citing as a goal a zbalance of Nature, Society and Humans'. Pre-industrial society had a different experience in using Nature and solving problems of life-support activity under a regime of sparing nature. Experience has shown that Folk knowledge and Folk technology can, in a number of instances, actually assist in solving high level problems caused by human impact on the environment, e.g., farming methods, and, as a result offering possibilities for a more sound and at the same time effective basis for long-term sustainable production at the local level. The traditional cultures of Eurasia were engaged in agricultural pursuits and had acquired unique experiences in maintaining soil fertility and a technology which limited the impact they were having on the environment. The value of Folk heritage in exploiting the environment, especially farming traditions in small-scale, non-industrial societies, has been based not only on the technologies that are "friendly" to Nature, but also (and first of all) on the perception that soil (earth) is the source of all life. This sort of perception was particularly widespread among peoples of pre-industrial societies. The problem of searching for a way to increase long-term productivity in food grain production is complicated. This problem is of global importance for today and the future. The active interest of Modern society in the Folk experiences of using the Nature to achieve sustainable economies is yet to come, but we have much to learn from these small-scale non-industrial societies. Food production needs to be increased. At the same time, the fertility of the soil must be maintained. Achieving a balance between these two necessities is the problem. Changing the present modern human outlook from its egocentric position to one that understands and respects the natural environment, based on ideas of "ecological ethics", looks especially complex, and is directly connected with the problem of forming a new culture. Actually, the global ecological crisis and related ecological problems take priority and the transition to a new model of thinking promises to be accelerated. In this context, making use of Folk heritage, Folk knowledge and experience in observing Nature and using Nature to achieve harmonious interrelations in a "Nature - Society" system, and for the elaboration of a change of attitudes is quite important for modern society on a Global level to achieve ways of Sustainability. Lucius Seneca maintains that subjugation of a Nature is possible only if obeying to Nature. Modern epoch of Globalization in economy and Financial systems creating a potential of high risks for mankind on the Global level. Special attention to local factors (local experience in Nature using, local Folk experience in Life-support activity) in context of globalization problems is important today. Actually, Glocalization can assist in adaptation process of harmonizing local and global needs to a way of Sustainability. Glocalization puts globalization problems down to the human scale. The age of Globalization has made the problem of cultural dialog extra actual, otherwise the Mankind has no chance to survive. The Glocalization is the process of creation of a harmony in Nature, Society and Humans system in the context of Sustainability.

A vision for Water Resources Research

NASA Astrophysics Data System (ADS)

Clark, M. P.

2017-12-01

Water Resources Research (WRR) plays a leading role in advancing hydrologic science. As AGU's hydrology journal, WRR has nurtured and published major breakthroughs in hydrologic process understanding and prediction capabilities, accomplished through innovative measurement campaigns, novel data analysis techniques, and elegant computational methods. Developing synergies between process-oriented and applications-oriented science is becoming more important as large changes in coupled human-natural systems impose new stresses on hydrologic systems and create new needs for hydrologic process understanding and prediction. In this presentation I will summarize some major opportunities for WRR, such as the growth of interdisciplinary science and the need for greater international cooperation through sharing of data and model source codes. I will discuss these opportunities in the context of major external trends, especially (1) changes in the perceived value of science to address societal problems, (2) the explosive global growth in science over the past decade, and (3) the transition to a more diffuse publishing landscape. This presentation is intended to foster discussion on ways that WRR can enhance the quality and impact of hydrologic science.

Diabetes mellitus and comorbid depression in Zambia.

PubMed

Hapunda, G; Abubakar, A; Pouwer, F; van de Vijver, F

2015-06-01

To replicate, in Zambia, a recent global study by the WHO, which reported that the odds of depression were not increased in African people with diabetes, and to explore the sociodemographic and clinical factors associated with depression. A total of 773 control subjects and 157 Zambian patients with diabetes completed the Major Depression Inventory and a list of demographic indicators. Compared with control subjects (mean ± sd Major Depression Inventory score 15.10 ± 9.19), depressive symptoms were significantly more common in patients with diabetes (mean ± sd Major Depression Inventory score 19.12 ± 8.95; P < 0.001). ancova showed that having diabetes [F(1,698) = 16.50, P < 0.001], being female [F(1,698) = 7.35, P < 0.01] and having low socio-economic status (F(1,698) = 13.35, P < 0.001) were positive predictors of depression. Contrary to the WHO study, we found that depression was a common comorbid health problem among Zambian people with diabetes. Clinicians should consider patients' health status, sex and socio-economic status as potential factors predicting depression. © 2014 The Authors. Diabetic Medicine © 2014 Diabetes UK.

Breast cancer: a neglected disease for the majority of affected women worldwide

PubMed Central

Love, Richard R.

2011-01-01

Recent progress with declines in mortality in some high income countries has obscured the fact that for the majority of women worldwide who are newly diagnosed, breast cancer is a neglected disease in the context of other numerically more frequent health problems. For this growing majority, it is also an orphan disease, in that detailed knowledge about tumor characteristics and relevant host biology necessary to provide even basic care are absent. With the possible exception of nutritional recommendations, current international cancer policy and planning initiatives are irrelevant to breast cancer. The progress that has occurred in high income countries has come at extraordinary fiscal expense and patient toxicity, which of themselves suggest non-relevance to women and health care practitioners in middle and low income countries. The implications of these circumstances seem clear: if the promise of the now 60 year-old Declaration of Human Rights, that the fruits of medical science accrue to all mankind, is to be realized with respect to breast cancer, a basic and translational global research initiative should be launched. PMID:21410589

Global planning of several plants

NASA Technical Reports Server (NTRS)

Bescos, Sylvie

1992-01-01

This paper discusses an attempt to solve the problem of planning several pharmaceutical plants at a global level. The interest in planning at this level is to increase the global control over the production process, to improve its overall efficiency, and to reduce the need for interaction between production plants. In order to reduce the complexity of this problem and to make it tractable, some abstractions were made. Based on these abstractions, a prototype is being developed within the framework of the EUREKA project PROTOS, using Constraint Logic Programming techniques.

A Chronologic Dual-Hemisphere Approach to the Last Glacial Termination from the Southern Alps of New Zealand and the Altai Mountains of Western Mongolia

NASA Astrophysics Data System (ADS)

Strand, P.; Putnam, A. E.; Schaefer, J. M.; Denton, G.; Barrell, D.; Putnam, D.; Schwartz, R.; Sambuu, O.; Radue, M. J.; Lindsay, B. J.; Stevens, J.

2017-12-01

Understanding the processes that drove the last glacial termination in the tropics and mid-latitudes is a major unresolved problem in paleoclimate. The most recent glacial to interglacial transition represents the last great global warming and the last time CO2 rose by a substantial amount before the industrial period. Determining the speed of this warming will help refine the global climate system sensitivity to CO2 and will place ongoing global warming into a paleoclimatic context. Here, we test possible drivers of the last glacial termination by comparing chronologies of mountain glaciers, which are highly sensitive to changes in atmospheric temperature, in the middle latitudes of both polar hemispheres. The dating of glacier landforms, such as moraine ridges constructed along glacier margins, affords quantitative insight into past climate conditions. We present 10Be surface-exposure chronologies and glacial geomorphologic maps of mountain glacier recession since the Last Glacial Maximum in the Southern Alps of New Zealand (44°S, 170°E) and in the Altai Mountains of western Mongolia (49°N, 88°E). On the basis of these chronologies from opposing hemispheres, we evaluate the relative roles of rising atmospheric CO2, local insolation forcing, and ocean-atmosphere reorganizations in driving the global warming that ended the last ice age.

Heart-Derived Stem Cells in Miniature Swine with Coronary Microembolization: Novel Ischemic Cardiomyopathy Model to Assess the Efficacy of Cell-Based Therapy

PubMed Central

Young, Rebeccah F.; Leiker, Merced M.; Suzuki, Takayuki

2016-01-01

A major problem in translating stem cell therapeutics is the difficulty of producing stable, long-term severe left ventricular (LV) dysfunction in a large animal model. For that purpose, extensive infarction was created in sinclair miniswine by injecting microspheres (1.5 × 106 microspheres, 45 μm diameter) in LAD. At 2 months after embolization, animals (n = 11) were randomized to receive allogeneic cardiosphere-derived cells derived from atrium (CDCs: 20 × 106, n = 5) or saline (untreated, n = 6). Four weeks after therapy myocardial function, myocyte proliferation (Ki67), mitosis (phosphor-Histone H3; pHH3), apoptosis, infarct size (TTC), myocyte nuclear density, and cell size were evaluated. CDCs injected into infarcted and remodeled remote myocardium (global infusion) increased regional function and global function contrasting no change in untreated animals. CDCs reduced infarct volume and stimulated Ki67 and pHH3 positive myocytes in infarct and remote regions. As a result, myocyte number (nuclear density) increased and myocyte cell diameter decreased in both infarct and remote regions. Coronary microembolization produces stable long-term ischemic cardiomyopathy. Global infusion of CDCs stimulates myocyte regeneration and improves left ventricular ejection fraction. Thus, global infusion of CDCs could become a new therapy to reverse LV dysfunction in patients with asymptomatic heart failure. PMID:27738436

Calibrating the Ordovician Radiation of marine life: implications for Phanerozoic diversity trends

NASA Technical Reports Server (NTRS)

Miller, A. I.; Foote, M.

1996-01-01

It has long been suspected that trends in global marine biodiversity calibrated for the Phanerozoic may be affected by sampling problems. However, this possibility has not been evaluated definitively, and raw diversity trends are generally accepted at face value in macroevolutionary investigations. Here, we analyze a global-scale sample of fossil occurrences that allows us to determine directly the effects of sample size on the calibration of what is generally thought to be among the most significant global biodiversity increases in the history of life: the Ordovician Radiation. Utilizing a composite database that includes trilobites, brachiopods, and three classes of molluscs, we conduct rarefaction analyses to demonstrate that the diversification trajectory for the Radiation was considerably different than suggested by raw diversity time-series. Our analyses suggest that a substantial portion of the increase recognized in raw diversity depictions for the last three Ordovician epochs (the Llandeilian, Caradocian, and Ashgillian) is a consequence of increased sample size of the preserved and catalogued fossil record. We also use biometric data for a global sample of Ordovician trilobites, along with methods of measuring morphological diversity that are not biased by sample size, to show that morphological diversification in this major clade had leveled off by the Llanvirnian. The discordance between raw diversity depictions and more robust taxonomic and morphological diversity metrics suggests that sampling effects may strongly influence our perception of biodiversity trends throughout the Phanerozoic.

On Health Education Becoming a Pedagogy of Global Health.

ERIC Educational Resources Information Center

Rittman, Joseph

1987-01-01

A review of the status and problems of international health education considers the effects of the economy on health expenditures and problems and the extent of education. Health education can begin to achieve greater bases for global health when it educates maximal health care users of counterproductive expenditures for health in the United…

Global threats from invasive species in the twenty-first century and national response capacities

USDA-ARS?s Scientific Manuscript database

Invasions are largely seen as a ‘First World’ problem, owing to the historic concentration of invasions in economically highly developed countries. However, we show that terrestrial invasions are fast becoming a global problem. The rapid rise in trade and transportation in developing economies in A...

Rationale for Students Preparation and Entrepreneurship Education in the Face of Global Economic Crisis in Nigeria

ERIC Educational Resources Information Center

Onuma, Nwite

2016-01-01

The rationale for students preparation in job creation through entrepreneurship education was examined. Problems of unemployment among Nigerian university graduates and challenges to entrepreneurship in the face of global economic crisis were also highlighted. The persistent problem of unemployment among University graduates and its attendant…

Heuristic Implementation of Dynamic Programming for Matrix Permutation Problems in Combinatorial Data Analysis

ERIC Educational Resources Information Center

Brusco, Michael J.; Kohn, Hans-Friedrich; Stahl, Stephanie

2008-01-01

Dynamic programming methods for matrix permutation problems in combinatorial data analysis can produce globally-optimal solutions for matrices up to size 30x30, but are computationally infeasible for larger matrices because of enormous computer memory requirements. Branch-and-bound methods also guarantee globally-optimal solutions, but computation…

A New Method for Global Optimization Based on Stochastic Differential Equations.

DTIC Science & Technology

1984-12-01

Optimizacion Global de Funciones, Universidad Nacional Autonoma de M~xico, Instituto de Investigaciones en Matematicas Aplicadas y en Sistemas, Report...SIGMA package and its usage are described in full de - tail in Annex A5; the complete listing of the FORTRAN code is in Annex A6. 5. Test problems Since...software implemen- tation on a number of test problems: and therefore a collection of test problems naturally began to build up during project de - velopment

Efficient Preconditioning for the p-Version Finite Element Method in Two Dimensions

DTIC Science & Technology

1989-10-01

paper, we study fast parallel preconditioners for systems of equations arising from the p-version finite element method. The p-version finite element...computations and the solution of a relatively small global auxiliary problem. We study two different methods. In the first (Section 3), the global...20], will be studied in the next section. Problem (3.12) is obviously much more easily solved than the original problem ,nd the procedure is highly

The Global Inventor Gap: Distribution and Equality of World-Wide Inventive Effort, 1990–2010

PubMed Central

Toivanen, Hannes; Suominen, Arho

2015-01-01

Applying distance-to-frontier analysis, we have used 2.9 million patents and population data to assess whether the relative capacity of world countries and major regions to create new knowledge and technology has become globally more equal or less equal between 1990 and 2010. We show with the Gini coefficient that the global distribution of inventors has become more equal between major countries and regions. However, this trend has been largely due to the improved performance of only two major countries, China and India. The worst performing regions, totalling a population of almost 2 billion, are actually falling behind. Our results suggest that substantial parts of the global population have fallen further behind countries at the global frontier in their ability to create new knowledge and inventions, and that the catch-up among the least developed and middle-income countries is highly uneven, prompting questions about the nature and future of the global knowledge economy. PMID:25849202

Global Energy Issues and Alternate Fueling

NASA Technical Reports Server (NTRS)

Hendricks, Robert C.

2007-01-01

This viewgraph presentation describes world energy issues and alternate fueling effects on aircraft design. The contents include: 1) US Uses about 100 Quad/year (1 Q = 10(exp 15) Btu) World Energy Use: about 433 Q/yr; 2) US Renewable Energy about 6%; 3) Nuclear Could Grow: Has Legacy Problems; 4) Energy Sources Primarily NonRenewable Hydrocarbon; 5) Notes; 6) Alternate Fuels Effect Aircraft Design; 7) Conventional-Biomass Issue - Food or Fuel; 8) Alternate fuels must be environmentally benign; 9) World Carbon (CO2) Emissions Problem; 10) Jim Hansen s Global Warming Warnings; 11) Gas Hydrates (Clathrates), Solar & Biomass Locations; 12) Global Energy Sector Response; 13) Alternative Renewables; 14) Stratospheric Sulfur Injection Global Cooling Switch; 15) Potential Global Energy Sector Response; and 16) New Sealing and Fluid Flow Challenges.

Multiple hybrid de novo genome assembly of finger millet, an orphan allotetraploid crop

PubMed Central

Hatakeyama, Masaomi; Aluri, Sirisha; Balachadran, Mathi Thumilan; Sivarajan, Sajeevan Radha; Patrignani, Andrea; Grüter, Simon; Poveda, Lucy; Shimizu-Inatsugi, Rie; Baeten, John; Francoijs, Kees-Jan; Nataraja, Karaba N; Reddy, Yellodu A Nanja; Phadnis, Shamprasad; Ravikumar, Ramapura L; Schlapbach, Ralph; Sreeman, Sheshshayee M; Shimizu, Kentaro K

2018-01-01

Abstract Finger millet (Eleusine coracana (L.) Gaertn) is an important crop for food security because of its tolerance to drought, which is expected to be exacerbated by global climate changes. Nevertheless, it is often classified as an orphan/underutilized crop because of the paucity of scientific attention. Among several small millets, finger millet is considered as an excellent source of essential nutrient elements, such as iron and zinc; hence, it has potential as an alternate coarse cereal. However, high-quality genome sequence data of finger millet are currently not available. One of the major problems encountered in the genome assembly of this species was its polyploidy, which hampers genome assembly compared with a diploid genome. To overcome this problem, we sequenced its genome using diverse technologies with sufficient coverage and assembled it via a novel multiple hybrid assembly workflow that combines next-generation with single-molecule sequencing, followed by whole-genome optical mapping using the Bionano Irys® system. The total number of scaffolds was 1,897 with an N50 length >2.6 Mb and detection of 96% of the universal single-copy orthologs. The majority of the homeologs were assembled separately. This indicates that the proposed workflow is applicable to the assembly of other allotetraploid genomes. PMID:28985356

Summary report of a workshop on phytoremediation research needs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1994-12-01

Soil contamination is a national and global problem. A major challenge is the remediation of large sites contaminated with radionuclides and toxic metals, often present in relatively small amounts but above regulatory action levels. Despite the function of phytoremediation processes in nature for millenia, the technology of phytoremediation is, for the most part, still a concept. There are many different pollutants, plant uptake mechanisms, soil matrices, and plant species that need to be investigated, without overlooking the microbial participation in this technology. Developing actual practical applications will require a significant and coordinated research and development effort, due to the complexitymore » of both biological systems and the soil contamination problems. Research and development in this area must involve scientists and engineers in Federal and state agencies, foreign organizations and industry. The representation at the workshop of researchers from many disciplines, organizations and countries, augurs well for a cooperative and interdisciplinary research effort and the rapid application of this technology. The urgent needs for effective, low-cost technologies to clean-up contaminated soils, both in the US and around the world, suggests phytoremediation as a high national and international research priority. The availability of scientists trained in the interdisciplinary topics relating to phytoremediation will be a major factor in expediting development of this technology.« less

Asthma and Chronic Obstructive Pulmonary Disease (COPD) – Differences and Similarities

PubMed Central

Cukic, Vesna; Lovre, Vladimir; Dragisic, Dejan; Ustamujic, Aida

2012-01-01

Bronchial asthma and COPD (chronic obstructive pulmonary disease) are obstructive pulmonary diseases that affected millions of people all over the world. Asthma is a serious global health problem with an estimated 300 million affected individuals. COPD is one of the major causes of chronic morbidity and mortality and one of the major public health problems worldwide. COPD is the fourth leading cause of death in the world and further increases in its prevalence and mortality can be predicted. Although asthma and COPD have many similarities, they also have many differences. They are two different diseases with differences in etiology, symptoms, type of airway inflammation, inflammatory cells, mediators, consequences of inflammation, response to therapy, course. Some similarities in airway inflammation in severe asthma and COPD and good response to combined therapy in both of these diseases suggest that they have some similar patophysiologic characteristics. The aim of this article is to show similarities and differences between these two diseases. Today asthma and COPD are not fully curable, not identified enough and not treated enough and the therapy is still developing. But in future better understanding of pathology, adequate identifying and treatment, may be and new drugs, will provide a much better quality of life, reduced morbidity and mortality of these patients. PMID:23678316

Prevalence of Shigella among diarrheic children under-5 years of age attending at Mekelle health center, north Ethiopia.

PubMed

Kahsay, Atsebaha Gebrekidan; Teklemariam, Zelalem

2015-12-15

Shigellosis is recognized as a major global public health problem especially in developing countries particularly in children under-5 years of age. Therefore; the objective of this study was to determine the prevalence of Shigella among diarrheic children under-5 years of age attending at Mekelle health center, north Ethiopia. A cross-sectional study was conducted among diarrheic children under-5 years of age from March to May, 2012. Structured questionnaire was used to collect the data. Study participants were recruited by convenience sampling technique. Shigella was isolated and identified using standard bacteriological techniques. A total of 241 study participants were included in the study. The overall prevalence of Shigella in this study was 13.3% (32/241). High prevalence of Shigella (22.6%) was revealed from the age group of 12-23 months. No Shigella was isolated from the age group of 0-5 months. Majority of the isolates of Shigella were from bloody and mucoid diarrhea. There was high prevalence of Shigella infection in this study. Children among the age group of 12-23 months were highly affected. Therefore; responsible bodies should work hard on preventive measures to reduce or eradicate the problem occurred due to shigellosis.

Influenza A virus vaccines for swine.

PubMed

Vincent, Amy L; Perez, Daniel R; Rajao, Daniela; Anderson, Tavis K; Abente, Eugenio J; Walia, Rasna R; Lewis, Nicola S

2017-07-01

Economic losses due to influenza A virus (IAV) infections are substantial and a global problem, ranking among the top three major health challenges in the swine industry. Currently, H1 and H3 subtypes circulate in pigs globally associated with different combinations of N1 and N2 subtypes; however, the origin, gene constellation, and antigenic makeup of IAV vary greatly on different continents. Vaccination is one means of mitigating the effects of IAV disease, and vaccines are most effective if the strains included closely match the currently circulating strains in pigs. Genetic analyses provide panoramic views of the virus landscape at the sequence level and, thus, can aid in the selection of well-matched swine IAV vaccine strains, but is not sufficient alone. Additionally, a major challenge in selecting appropriate swine IAV vaccine strains is the co-circulation of multiple lineages of viruses in the same region, requiring multivalent or broadly cross-reacting antigens. Due to this complex IAV ecology in swine, new vaccination strategies and vaccine platforms are needed. The hemagglutinin (HA) viral protein is the major target of neutralizing antibodies, which are widely considered to be correlated with protection. Virus variants that are not recognized by previously elicited antibodies can render traditional vaccines that primarily elicit humoral responses ineffective, and therefore result in the need for vaccine strain reformulation and re-vaccination. In the future, new vaccine platforms may be on the market that will provide alternative options to those currently available. Nonetheless, a collaborative approach is needed to improve IAV vaccine strain selection for use in swine. Published by Elsevier B.V.

Advanced long-term bird banding and climate data mining in spring confirm passerine population declines for the Northeast Chinese-Russian flyway

NASA Astrophysics Data System (ADS)

Jiao, Shengwu; Huettmann, Falk; Guo, Yumin; Li, Xianda; Ouyang, Yanlan

2016-09-01

The migration of birds is fascinating for humans but it's also a serious environmental monitoring and management issue on a global level. Bird banding using mistnets has been the method of choice for decades worldwide; linking these data with climate data allows to infer on global warming and outlier events. However, good methods to achieve this effectively in time and space for many species are still missing; data for Asia are specifically sparse and often 'messy'. Here we present a data mining summary information for data from two bird banding stations (Gaofeng and Qingfeng) along the vast Northeast Chinese-Russian flyway. Bird data were collected during spring 2002-2011 with standardized techniques and then linked with related climate data in the banding as well as the wintering sites. This creates a complex data set which is based on a decade and which includes many predictors. This first-time data mining analysis with 'data cloning' and machine learning methods (boosted regression trees) shows how to extract the major signals in this unique dataset from highly correlated and interacting predictors. Our results indicate a large-scale warming trend for the flyway, with a start in 2003, and a freezing rain outlier event in 2008; the last years remained on a rather warm level. All evidence along this vast flyway supports major changes, warming trends, habitat losses and consequently strong passerine declines. Presumably human pressures are a major factor either way and we propose to address these problems immediately for betterment if meaningful conservation targets are to be met.

Prevalence of Trachoma in Benishangul Gumuz Region, Ethiopia: Results of Seven Population-Based Surveys from the Global Trachoma Mapping Project.

PubMed

Adamu, Yilikal; Macleod, Colin; Adamu, Liknaw; Fikru, Wirtu; Kidu, Beyene; Abashawl, Aida; Dejene, Michael; Chu, Brian K; Flueckiger, Rebecca M; Willis, Rebecca; Pavluck, Alexandre L; Solomon, Anthony W

2016-01-01

Trachoma is a major cause of blindness in Ethiopia, and targeted for elimination as a public health problem by the year 2020. Prevalence data are needed to plan interventions. We set out to estimate the prevalence of trachoma in each evaluation unit of grouped districts ("woredas") in Benishangul Gumuz region, Ethiopia. We conducted seven cross-sectional community-based surveys, covering 20 woredas, between December 2013 and January 2014, as part of the Global Trachoma Mapping Project (GTMP). The standardized GTMP training package and methodologies were used. A total of 5828 households and 21,919 individuals were enumerated in the surveys. 19,583 people (89.3%) were present when survey teams visited. A total of 19,530 (99.7%) consented to examination, 11,063 (56.6%) of whom were female. The region-wide age- and sex-adjusted trichiasis prevalence in adults aged ≥15 years was 1.3%. Two evaluation units covering four woredas (Pawe, Mandura, Bulen and Dibate) with a combined rural population of 166,959 require implementation of the A, F and E components of the SAFE strategy (surgery, antibiotics, facial cleanliness and environmental improvement) for at least three years before re-survey, and intervention planning should begin for these woredas as soon as possible. Both active trachoma and trichiasis are public health problems in Benishangul Gumuz, which needs implementation of the full SAFE strategy.

Setting the scene: the challenges of universal health coverage and the contribution of management education.

PubMed

Tarricone, Rosanna

2013-01-01

The last decades are being characterized by global trends such as population growth, aging, escalation of non communicable diseases and technological innovation. These unprecedented changes are moving faster than economic growth and threaten universal health coverage. What is at stake nowadays is governments' and healthcare systems' ability to renovate themselves and develop new paradigms aimed at finding innovative solutions to manage the new global forces so to maintain universal access to care in a changing environment. We have to be imaginative because if we keep relying on current paradigms to answer already too far-ahead complex problems, we will fail. And here education has a role to play. Although the recent years have seen a steep increase in the offerings of post-graduate management education programs in health and healthcare, the majority of these programs are still traditionally conceived and designed, aiming to train students to deal with specific, domestic, current problems. With the promise of making students the best specialists on Earth, to get the highest return on his or her investment in education, the performance of these programs is often measured in terms of earnings maximization. Although an indicator of success, this often incentivizes individuals to be context-based, individualistic, short-sighted and self-focused. Education has the greatest potential to foster imagination, to leverage diversity, to exploit team-working and free creative thinking. Education can substantially contribute to anticipate the impact of global forces by but an endeavor is needed to design programs and measures performances differently. Copyright © 2013 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.

Global Health and Emergency Care: Defining Clinical Research Priorities.

PubMed

Hansoti, Bhakti; Aluisio, Adam R; Barry, Meagan A; Davey, Kevin; Lentz, Brian A; Modi, Payal; Newberry, Jennifer A; Patel, Melissa H; Smith, Tricia A; Vinograd, Alexandra M; Levine, Adam C

2017-06-01

Despite recent strides in the development of global emergency medicine (EM), the field continues to lag in applying a scientific approach to identifying critical knowledge gaps and advancing evidence-based solutions to clinical and public health problems seen in emergency departments (EDs) worldwide. Here, progress on the global EM research agenda created at the 2013 Academic Emergency Medicine Global Health and Emergency Care Consensus Conference is evaluated and critical areas for future development in emergency care research internationally are identified. A retrospective review of all studies compiled in the Global Emergency Medicine Literature Review (GEMLR) database from 2013 through 2015 was conducted. Articles were categorized and analyzed using descriptive quantitative measures and structured data matrices. The Global Emergency Medicine Think Tank Clinical Research Working Group at the Society for Academic Emergency Medicine 2016 Annual Meeting then further conceptualized and defined global EM research priorities utilizing consensus-based decision making. Research trends in global EM research published between 2013 and 2015 show a predominance of observational studies relative to interventional or descriptive studies, with the majority of research conducted in the inpatient setting in comparison to the ED or prehospital setting. Studies on communicable diseases and injury were the most prevalent, with a relative dearth of research on chronic noncommunicable diseases. The Global Emergency Medicine Think Tank Clinical Research Working Group identified conceptual frameworks to define high-impact research priorities, including the traditional approach of using global burden of disease to define priorities and the impact of EM on individual clinical care and public health opportunities. EM research is also described through a population lens approach, including gender, pediatrics, and migrant and refugee health. Despite recent strides in global EM research and a proliferation of scholarly output in the field, further work is required to advocate for and inform research priorities in global EM. The priorities outlined in this paper aim to guide future research in the field, with the goal of advancing the development of EM worldwide. © 2017 by the Society for Academic Emergency Medicine.

The effects of transboundary air pollution following major events in China on air quality in the U.S.: Evidence from Chinese New Year and sandstorms.

PubMed

Ngo, N S; Zhong, N; Bao, X

2018-04-15

Transboundary air pollution is a global environmental and public health problem including in the U.S., where pollution emissions from China, the largest emitter of anthropogenic air pollution in the world, can travel across the Pacific Ocean and reach places like California and Oregon. We examine the effects of transboundary air pollution following major events in China, specifically sandstorms, a natural-occurring source of air pollution, and Chinese New Year, a major 7-day holiday, on background air quality in the U.S. We focus on high elevation sites on the west coast between 2000 and 2013. We use regression analysis and a natural experiment to exploit the variation in the timing of these events in China, which are plausibly uncorrelated to other factors that affect air quality in China and the U.S. We find that sandstorms are associated with statistically significant increases in background coarse and fine particulate matter (PM) in the U.S., representing between 16 and 39% of average weekly PM levels. We also find Chinese New Year is associated with modest reductions in background air quality in the U.S., representing between 0.4 and 2.5% of PM levels. Findings are robust to different models and falsification tests. These results suggest that regression analysis could be a powerful tool to complement other, more widely used techniques in the environmental sciences that study this problem. This also has important implications for policymakers, who could track major sandstorms in China and prepare for possible increased foreign pollution emissions in the U.S. Copyright © 2018 Elsevier Ltd. All rights reserved.

The problem of epistemic jurisdiction in global governance: The case of sustainability standards for biofuels.

PubMed

Winickoff, David E; Mondou, Matthieu

2017-02-01

While there is ample scholarly work on regulatory science within the state, or single-sited global institutions, there is less on its operation within complex modes of global governance that are decentered, overlapping, multi-sectorial and multi-leveled. Using a co-productionist framework, this study identifies 'epistemic jurisdiction' - the power to produce or warrant technical knowledge for a given political community, topical arena or geographical territory - as a central problem for regulatory science in complex governance. We explore these dynamics in the arena of global sustainability standards for biofuels. We select three institutional fora as sites of inquiry: the European Union's Renewable Energy Directive, the Roundtable on Sustainable Biomaterials, and the International Organization for Standardization. These cases allow us to analyze how the co-production of sustainability science responds to problems of epistemic jurisdiction in the global regulatory order. First, different problems of epistemic jurisdiction beset different standard-setting bodies, and these problems shape both the content of regulatory science and the procedures designed to make it authoritative. Second, in order to produce global regulatory science, technical bodies must manage an array of conflicting imperatives - including scientific virtue, due process and the need to recruit adoptees to perpetuate the standard. At different levels of governance, standard drafters struggle to balance loyalties to country, to company or constituency and to the larger project of internationalization. Confronted with these sometimes conflicting pressures, actors across the standards system quite self-consciously maneuver to build or retain authority for their forum through a combination of scientific adjustment and political negotiation. Third, the evidentiary demands of regulatory science in global administrative spaces are deeply affected by 1) a market for standards, in which firms and states can choose the cheapest sustainability certification, and 2) the international trade regime, in which the long shadow of WTO law exerts a powerful disciplining function.

Global Optimization Ensemble Model for Classification Methods

PubMed Central

Anwar, Hina; Qamar, Usman; Muzaffar Qureshi, Abdul Wahab

2014-01-01

Supervised learning is the process of data mining for deducing rules from training datasets. A broad array of supervised learning algorithms exists, every one of them with its own advantages and drawbacks. There are some basic issues that affect the accuracy of classifier while solving a supervised learning problem, like bias-variance tradeoff, dimensionality of input space, and noise in the input data space. All these problems affect the accuracy of classifier and are the reason that there is no global optimal method for classification. There is not any generalized improvement method that can increase the accuracy of any classifier while addressing all the problems stated above. This paper proposes a global optimization ensemble model for classification methods (GMC) that can improve the overall accuracy for supervised learning problems. The experimental results on various public datasets showed that the proposed model improved the accuracy of the classification models from 1% to 30% depending upon the algorithm complexity. PMID:24883382

Diabetes mellitus and the β-cell: the Last Ten Years

PubMed Central

Ashcroft, Frances M; Rorsman, Patrik

2018-01-01

Diabetes is a major global problem. During the past decade, the genetic basis of various monogenic forms of the disease, and their underlying molecular mechanisms, have been elucidated. Many genes that increase type-2 diabetes (T2DM) risk have also been identified but how they do so remains enigmatic. Nevertheless, defective insulin secretion emerges as the main culprit in both monogenic and polygenic diabetes, with environmental and lifestyle factors, via obesity, accounting for the current dramatic increase in T2DM. There also have been significant advances in therapy, particularly for some monogenic disorders. We review here what ails the beta-cell and how its function may be restored. PMID:22424227

Assimilation of satellite color observations in a coupled ocean GCM-ecosystem model

NASA Technical Reports Server (NTRS)

Sarmiento, Jorge L.

1992-01-01

Monthly average coastal zone color scanner (CZCS) estimates of chlorophyll concentration were assimilated into an ocean global circulation model(GCM) containing a simple model of the pelagic ecosystem. The assimilation was performed in the simplest possible manner, to allow the assessment of whether there were major problems with the ecosystem model or with the assimilation procedure. The current ecosystem model performed well in some regions, but failed in others to assimilate chlorophyll estimates without disrupting important ecosystem properties. This experiment gave insight into those properties of the ecosystem model that must be changed to allow data assimilation to be generally successful, while raising other important issues about the assimilation procedure.

International Approaches in Human Rights Education

NASA Astrophysics Data System (ADS)

Lohrenscheit, Claudia

2002-07-01

This paper was presented at a working group on Human Rights Education (HRE), organised by Volker Lenhart and Christel Adick, as part of the biennial conference of the German Society for Educational Research (DGfE), held in 2000 in Göttingen. In the spirit of the United Nations Decade for Human Rights Education (1995-2004) it contributes to the global discourse about HRE by summarising its foundations in international declarations and conventions, by discussing some examples for diverse approaches and conceptions of HRE and, finally by introducing some major obstacles or problems. The paper is part of the author's PhD project in the field of HRE and presents only an interim résumé of her recent work.

[The Seintinelles: an innovative approach to promoting Community-Based Research and sustaining health democracy in oncology].

PubMed

Bauquier, Charlotte; Pannard, Myriam; Préau, Marie

2017-10-02

Community-based research drives innovation in major fields of public health, HIV/AIDS being the most emblematic example (Demange, Henry & Préau, 2012), and hepatitis. However, this type of research appears to be more difficult to develop in certain specific diseases, such as cancer (Shankand, Saïas & Friboulet, 2009). This article proposes various approaches concerning current citizen mobilization in relation to cancer research, including potential new levers to the development of participative and community-based research based on the recent creation of the Seintinelles platform, designed to federate researchers and citizens concerned by the problem of cancer. This reflection will be supported by more global issues concerning health democracy.

Idiopathic ulcers as an oral manifestation in pediatric patients with AIDS: multidisciplinary management.

PubMed

Martinez-Sandoval, B; Ceballos-Hernández, H; Téllez-Rodríguez, J; Xochihua-Díaz, L; Durán-Ibarra, G; Pozos-Guillen, A J

2012-01-01

HIV infection is a major global health problem affecting developing and developed countries alike. HIV infection is associated with multiple oral lesions, some of which are of value in diagnosing the disease. The aim of this report is to describe the clinical manifestations and their multidisciplinary management, in a 6-year-old girl with AIDS. The findings of this case report indicate that, it is essential to be familiar with the early oral manifestations of AIDS in order to understand the patient's dental health needs, apply preventive methods, control caries, and understand the value of oral lesions as diagnostic markers of disease progression in children with HIV infection. A multidisciplinary management is fundamental.

Prevalence of Batrachochytrium dendrobatidis and B. salamandrivorans in the Gulf Coast Waterdog, Necturus beyeri, from Southeast Louisiana, USA

USGS Publications Warehouse

Glorioso, Brad M.; Waddle, J. Hardin; Richards-Zawacki, Corinne L.

2017-01-01

The globally widespread amphibian fungal pathogen Batrachochytrium dendrobatidis (Bd) has been linked to amphibian declines worldwide (Lips et al. 2006; Skerratt et al. 2007). In Louisiana, USA, Bd has been found in several amphibian species (Chatfield et al. 2012; Rothermel et al. 2008), but to our knowledge no population-level die-offs have been observed. Published literature on Bd prevalence in Louisiana is scant for some amphibian species and completely absent for many others. This trend is likely driven by the perception that Bd is not a major problem in this area due to a lack of observed dieoffs attributable to chytridiomycosis.

Metabolomics window into diabetic complications.

PubMed

Wu, Tao; Qiao, Shuxuan; Shi, Chenze; Wang, Shuya; Ji, Guang

2018-03-01

Diabetes has become a major global health problem. The elucidation of characteristic metabolic alterations during the diabetic progression is critical for better understanding its pathogenesis, and identifying potential biomarkers and drug targets. Metabolomics is a promising tool to reveal the metabolic changes and the underlying mechanism involved in the pathogenesis of diabetic complications. The present review provides an update on the application of metabolomics in diabetic complications, including diabetic coronary artery disease, diabetic nephropathy, diabetic retinopathy and diabetic neuropathy, and this review provides notes on the prevention and prediction of diabetic complications. © 2017 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.

The Need for Hydrologists in the Third World.

NASA Astrophysics Data System (ADS)

Sedlar, F.

2014-12-01

The United Nations estimates that by 2040 there will be 2 billion people living in slums around the world. Though the problems surrounding slums are varied and unique to each location, water is almost always the major concern. From physical issues such as water scarcity, treatment, and flooding to political issues including water privatization and distribution, water manifests itself in many complex, negative and unconventional ways in the global slums. Although many human rights and aid organizations are already doing important work in slums around the world I argue that the technical knowledge and perspectives that hydrologists have, particularly early career hydrologists, are extremely unique and desperately required in slums the world over.

Brief historical perspectives of malaria in Iran.

PubMed

Azizi, Mohammad Hossein; Bahadori, Moslem

2013-02-01

The history of malaria as a serious human disease dates back to ancient times. For centuries, malaria has been a deadly disease with high morbidity and mortality that profoundly impacted the socioeconomic status of endemic countries. However, its causative agent remained unidentified until the last decades of the nineteenth century. There were no effective synthetic anti-malarial agents until the mid-twentieth century. Currently malaria has been eliminated or pre-eliminated in numerous countries; however, this preventable and curable disease remains a significant global health problem. A major concern is drug resistance. Presented here, is a brief look at the history of malaria in Iran and the rest of the world, particularly during the nineteenth and twentieth centuries.

[Impact of HIV/HBV infection and HIV/HBV co-infection on outcomes of pregnancy].

PubMed

Yang, Y; Cheng, W T; Zhou, Y B; Jiang, Q W

2017-06-10

Both HIV and HBV infection have become major health problems, of global concern, due to the high prevalence in the past few decades. Data from cumulated epidemiological surveys have shown the links between maternal HIV or HBV infection and adverse outcomes on pregnancy. Maternal HIV or HBV infection may also increase the mother-to-child (MTCT) transmission of the two diseases. However, association between HIV-HBV co-infection and adverse pregnancy is still inconclusive. Does maternal HIV-HBV co-infection have an impact on mother-to-child transmission on either HIV or HBV? Study on effective precautionary measures to promote both maternal and child's health is deemed necessary.

Large-scale pollution of the atmosphere over the remote Atlantic Ocean: Evidence from Bermuda

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dickerson, R.R.; Doddridge, B.G.; Kelley, P.

1995-05-20

Ozone acts as a greenhouse gas and controls much of the oxidizing capacity of the atmosphere. Photochemical production of ozone in urban areas (smog) is a serious environmental problem, but how far this process extends on regional or global scales remains a major unanswered question in atmospheric science. In summer, Bermuda basks in pristine marine air, but in spring, episodes of high ozone are common. From meteorological analyses and observation of ozone, carbon monoxide, and reactive nitrogen compounds, the authors conclude that half or more of the excess ozone in Bermuda originates from air pollution over eastern North America. 50more » refs., 7 figs., 2 tabs.« less

Natural history of chronic hepatitis B virus infection.

PubMed

Busch, Katrin; Thimme, Robert

2015-02-01

Hepatitis B virus infection represents a major global health problem. Currently, there are more than 240 million chronically infected people worldwide. The development of chronic hepatitis B virus-mediated liver disease may lead to liver fibrosis, cirrhosis and eventually hepatocellular carcinoma. Recently, the discovery of the viral entry receptor sodium taurocholate cotransporting polypeptide has facilitated new approaches for a better understanding of viral physiopathology. Hopefully, these novel insights may give rise to the development of more effective antiviral therapy concepts during the next years. In this review, we will discuss the natural history of hepatitis B virus infection including the viral biology, the clinical course of infection and the role of the immune response.

Prevalence and Correlates of Sleep Problems in Adult Israeli Jews Exposed to Actual or Threatened Terrorist or Rocket Attacks

PubMed Central

Palmieri, Patrick A.; Chipman, Katie J.; Canetti, Daphna; Johnson, Robert J.; Hobfoll, Stevan E.

2010-01-01

Study Objectives: To estimate the prevalence of, and to identify correlates of clinically significant sleep problems in adult Israeli citizens exposed to chronic terrorism and war trauma or threat thereof. Methods: A population-based, cross-sectional study of 1001 adult Israeli citizens interviewed by phone between July 15 and August 26, 2008. The phone survey was conducted in Hebrew and assessed demographics, trauma/stressor exposure, probable posttraumatic stress disorder (PTSD), probable depression, and sleep problems. Probable PTSD and depression were assessed with the PTSD Symptom Scale (PSS) and Patient Health Questionnaire (PHQ-9), respectively, following DSM-IV diagnostic criteria. Sleep problems in the past month were assessed with the Pittsburgh Sleep Quality Index (PSQI), on which a global composite score ≥ 6 indicates a clinical-level sleep problem. Results: Prevalence of probable PTSD and depression was 5.5% and 5.8%, respectively. Prevalence of clinically significant sleep problems was 37.4% overall, but was significantly higher for probable PTSD (81.8%) and probable depression (79.3%) subgroups. Independent correlates of poor sleep included being female, older, less educated, experiencing major life stressors, and experiencing psychosocial resource loss. Psychosocial resource loss due to terrorist attacks emerged as the strongest potentially modifiable risk factor for sleep problems. Conclusions: Sleep problems are common among Israeli adults living under chronic traumatic threat and trauma exposure. Given the continuing threat of war, interventions that bolster psychosocial resources may play an important role in preventing or alleviating sleep problems in this population. Citation: Palmieri PA; Chipman KJ; Canetti D; Johnson RJ; Hobfoll SE. Prevalence and correlates of sleep problems in adult Israeli Jews exposed to actual or threatened terrorist or rocket attacks. J Clin Sleep Med 2010;6(6):557-564. PMID:21206544

On a numerical solving of random generated hexamatrix games

NASA Astrophysics Data System (ADS)

Orlov, Andrei; Strekalovskiy, Alexander

2016-10-01

In this paper, we develop a global search method for finding a Nash equilibrium in a hexamatrix game (polymatrix game of three players). The method, on the one hand, is based on the equivalence theorem of the problem of finding a Nash equilibrium in the game and a special mathematical optimization problem, and, on the other hand, on the usage of Global Search Theory for solving the latter problem. The efficiency of this approach is demonstrated by the results of computational testing.

Life on the Edge - Improved Forest Cover Mapping in Mixed-Use Tropical Regions

NASA Astrophysics Data System (ADS)

Anderson, C.; Mendenhall, C. D.; Daily, G.

2016-12-01

Tropical ecosystems and biodiversity are experiencing rapid change, primarily due to conversion of forest habitat to agriculture. Protected areas, while effective for conservation, only manage 15% of terrestrial area, whereas approximately 58% is privately owned. To incentivize private forest management and slow the loss of biodiversity, payments for ecosystem services (PES) programs were established in Costa Rica that pay landowners who maintain trees on their property. While this program is effective in improving livelihoods and preventing forest conversion, it is only managing payments to landowners on 1% of eligible, non-protected forested land.A major bottleneck for this program is access to accurate, national-scale tree cover maps. While the remote sensing community has made great progress in global-scale tree cover mapping, these maps are not sufficient to guide investments for PES programs. The major limitations of current global-scale tree-cover maps are that they a) do not distinguish between forest and agriculture and b) overestimate tree cover in mixed land-use areas (e.g. Global Forest Change overestimates by 20% on average in this region). This is especially problematic in biodiversity-rich Costa Rica, where small patches of forest intermix with agricultural production, and where the conservation value of tree-cover is high. To address this problem, we are developing a new forest cover mapping method that a) performs a least-squares spectral mixture analysis (SMA) using repeat Landsat imagery and canopy radiative transfer modeling: b) combines Landsat data, SMA results, and radar backscatter data using multi-sensor fusion techniques and: c) trains tree-cover classification models using high resolution data sets along a land use-intensity gradient. Our method predicted tree cover with 85% accuracy when compared to a fine-scale map of tree cover in a tropical, agricultural landscape, whereas the next-best method, the Global Forest Change map, predicted tree cover with 72% accuracy. Next steps will aim to test, improve, and apply this method globally to guide investments in nature in agricultural landscapes where forest stewardship will sustain biodiversity.

Global Futures: The Emerging Scenario.

ERIC Educational Resources Information Center

Seth, Satish C.

1983-01-01

Acknowledging global interdependence, especially in economics, may be the most important step toward resolving international conflicts. Describes seven major global dangers and gives scenarios for exploring likely global futures. As "tools of prescription" these global models are inadequate, but as "tools of analysis" they have…

Global Optimal Trajectory in Chaos and NP-Hardness

NASA Astrophysics Data System (ADS)

Latorre, Vittorio; Gao, David Yang

This paper presents an unconventional theory and method for solving general nonlinear dynamical systems. Instead of the direct iterative methods, the discretized nonlinear system is first formulated as a global optimization problem via the least squares method. A newly developed canonical duality theory shows that this nonconvex minimization problem can be solved deterministically in polynomial time if a global optimality condition is satisfied. The so-called pseudo-chaos produced by linear iterative methods are mainly due to the intrinsic numerical error accumulations. Otherwise, the global optimization problem could be NP-hard and the nonlinear system can be really chaotic. A conjecture is proposed, which reveals the connection between chaos in nonlinear dynamics and NP-hardness in computer science. The methodology and the conjecture are verified by applications to the well-known logistic equation, a forced memristive circuit and the Lorenz system. Computational results show that the canonical duality theory can be used to identify chaotic systems and to obtain realistic global optimal solutions in nonlinear dynamical systems. The method and results presented in this paper should bring some new insights into nonlinear dynamical systems and NP-hardness in computational complexity theory.

The Evaluation of Reflective Learning Practice: Preparing College Students for Globalization

ERIC Educational Resources Information Center

Richard, Cathleen Becnel

2010-01-01

A problem facing education today is that learning typically requires rote memorization rather than the use of higher-order thinking skills. Higher-order thinking is needed in a global society to solve real world problems, therefore students should be required to develop and practice higher-order thinking skills. The purpose of this mixed method…

A Collection of Studies Conducted in Education about "Global Warming" Problem

ERIC Educational Resources Information Center

Bozdogan, Aykut Emre

2011-01-01

The studies global warming problem conducted in education discipline in the world and in Turkey were analysed for this study. The literature was reviewed extensively especially through the articles in the indexed journals of Ebsco Host, Science Direct, Taylor and Francis and Web of Science databases and this study was conducted according to the…

Man in the Living Environment. A Report on Global Ecological Problems.

ERIC Educational Resources Information Center

Inger, Robert F.; And Others

The findings of four groups of ecologists are synthesized in chapter I of this report on global ecological problems prepared as a data base for the United Nations Conference on the Human Environment. The other chapters contain the reports of each group. In "Cycles of Elements" the biologically important elements, phosphorus, sulfur, and nitrogen,…

Rio Grande Basin and the modern world: Understanding scale and context

Treesearch

Joseph A. Tainter

1999-01-01

Environmental problems are social issues, embedded in economic and political contexts at the local, regional, national, and global levels. Placing environmental issues on the scale from local to global clarifies conflicts between the level at which problems originate and the level at which they must be addressed. Local issues today often originate in sources distant in...

The Loss of Genetic Diversity: An Impending Global Issue.

ERIC Educational Resources Information Center

Pierce, James P.

Definitions of biosphere and ecosystem are provided as the basis for understanding a problem that threatens to become (or already is) a global issue, namely, human activity which results in reducing the diversity of life forms present in the biosphere as an ecosystem. Two aspects of this problem are: (1) the growth of human populations worldwide…

Global nitrogen overload problem grows critical

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moffat, A.S.

1998-02-13

This article discusses a global problem due to man`s intervention in the biosphere resulting from an increased production and usage of products producing nitrogen compounds which can be fixed in ecosystems. This problem was recognized on small scales even in the 1960`s, but recent studies on a more global scale show that the amount of nitrogen compounds in river runoff is strongly related to the use of synthetic fertilizers, fossil-fuel power plants, and automobile emissions. The increased fixed nitrogen load is exceeding the ability of some ecosystems to use or break the compounds down, resulting in a change in themore » types of flora and fauna which are found to inhabit the ecosystems, and leading to decreased biodiversity.« less

Global, finite energy, weak solutions for the NLS with rough, time-dependent magnetic potentials

NASA Astrophysics Data System (ADS)

Antonelli, Paolo; Michelangeli, Alessandro; Scandone, Raffaele

2018-04-01

We prove the existence of weak solutions in the space of energy for a class of nonlinear Schrödinger equations in the presence of a external, rough, time-dependent magnetic potential. Under our assumptions, it is not possible to study the problem by means of usual arguments like resolvent techniques or Fourier integral operators, for example. We use a parabolic regularisation, and we solve the approximating Cauchy problem. This is achieved by obtaining suitable smoothing estimates for the dissipative evolution. The total mass and energy bounds allow to extend the solution globally in time. We then infer sufficient compactness properties in order to produce a global-in-time finite energy weak solution to our original problem.

Developing Scientific Literacy Skills through Interdisciplinary, Technology-Based Global Simulations: GlobalEd 2

ERIC Educational Resources Information Center

Lawless, Kimberly A.; Brown, Scott W.

2015-01-01

GlobalEd 2 (GE2) is a set of technology-mediated, problem-based learning (PBL) simulations for middle-grade students, that capitalises on the multidisciplinary nature of the social sciences as an expanded curricular space for students to learn and apply scientific literacies and concepts, while simultaneously also enriching their understanding of…

Agricultural Management Practices Explain Variation in Global Yield Gaps of Major Crops

NASA Astrophysics Data System (ADS)

Mueller, N. D.; Gerber, J. S.; Ray, D. K.; Ramankutty, N.; Foley, J. A.

2010-12-01

The continued expansion and intensification of agriculture are key drivers of global environmental change. Meeting a doubling of food demand in the next half-century will further induce environmental change, requiring either large cropland expansion into carbon- and biodiversity-rich tropical forests or increasing yields on existing croplands. Closing the “yield gaps” between the most and least productive farmers on current agricultural lands is a necessary and major step towards preserving natural ecosystems and meeting future food demand. Here we use global climate, soils, and cropland datasets to quantify yield gaps for major crops using equal-area climate analogs. Consistent with previous studies, we find large yield gaps for many crops in Eastern Europe, tropical Africa, and parts of Mexico. To analyze the drivers of yield gaps, we collected sub-national agricultural management data and built a global dataset of fertilizer application rates for over 160 crops. We constructed empirical crop yield models for each climate analog using the global management information for 17 major crops. We find that our climate-specific models explain a substantial amount of the global variation in yields. These models could be widely applied to identify management changes needed to close yield gaps, analyze the environmental impacts of agricultural intensification, and identify climate change adaptation techniques.