Unresolved Technical Issues in Fair Interest Measurement.

ERIC Educational Resources Information Center

Cole, Nancy S.

The problem of sex differences in interest measurement involves many technical issues and procedures. The purpose of this paper is to provide a description of the technical problems involved in construction, scoring, and interpretation of interest measures as related to sex differences and to suggest guidelines within these technical issues which…

Partially-Averaged Navier Stokes Model for Turbulence: Implementation and Validation

NASA Technical Reports Server (NTRS)

Girimaji, Sharath S.; Abdol-Hamid, Khaled S.

2005-01-01

Partially-averaged Navier Stokes (PANS) is a suite of turbulence closure models of various modeled-to-resolved scale ratios ranging from Reynolds-averaged Navier Stokes (RANS) to Navier-Stokes (direct numerical simulations). The objective of PANS, like hybrid models, is to resolve large scale structures at reasonable computational expense. The modeled-to-resolved scale ratio or the level of physical resolution in PANS is quantified by two parameters: the unresolved-to-total ratios of kinetic energy (f(sub k)) and dissipation (f(sub epsilon)). The unresolved-scale stress is modeled with the Boussinesq approximation and modeled transport equations are solved for the unresolved kinetic energy and dissipation. In this paper, we first present a brief discussion of the PANS philosophy followed by a description of the implementation procedure and finally perform preliminary evaluation in benchmark problems.

[Proposal of a different interpretation of the physiology of labor useful in more edifying teaching of obstetric psychoprophylaxis courses].

PubMed

Mergoni, A

1994-01-01

Without underestimating the undeniable benefit which can be achieved from various physical and mental relaxation exercises, the author expresses the conviction that the didactic and cultural aspect of preparative courses during pregnancy by definition improve, to a greater extent than is widely believed, the positive outcome of obstetric psychoprophylaxis. It is therefore opportune that the didactic part of courses should cover a wider and more detailed range than is usually the case, in particular including a more exhaustive and accurate description of the mechanical phenomenon of birth. Without a clear knowledge and awareness of such mechanical aspects, pregnant women will not feel prepared for and in full and rational control of her own labour. Given that a correct knowledge of the physiology of labour inevitably includes aspects which will enrich the pregnant woman's psyche, the author hopes that interest will soon be reawakened in the physiology of labour whose interpretation has for a long time contained a number of basic and unresolved problems. In order to rectify and further our knowledge of the physiology of labour, it is important to be willing to consider other interpretative models which differ from the traditional one. On this subject, the author aims to rediscuss one model in which Pascal's principle is recognised as the decisive cause of the majority of the mechanical phenomena of labour, and which, in addition to providing solutions to many unresolved problems, makes the teaching of preparative courses during pregnancy more edifying in psychological terms.

Problems and Issues of Diversity in the United States.

ERIC Educational Resources Information Center

Naylor, Larry L., Ed.

A number of social problems created by cultural diversity in the United States seem to defy resolution. The essays in this collection address some of these issues and are designed to initiate serious discussions on some of the most serious questions. The chapters are: (1) "Introduction to American Cultural Diversity: Unresolved Questions, Issues,…

Inflammation, aging, and cancer: tumoricidal versus tumorigenesis of immunity: a common denominator mapping chronic diseases.

PubMed

Khatami, Mahin

2009-01-01

Acute inflammation is a highly regulated defense mechanism of immune system possessing two well-balanced and biologically opposing arms termed apoptosis ('Yin') and wound healing ('Yang') processes. Unresolved or chronic inflammation (oxidative stress) is perhaps the loss of balance between 'Yin' and 'Yang' that would induce co-expression of exaggerated or 'mismatched' apoptotic and wound healing factors in the microenvironment of tissues ('immune meltdown'). Unresolved inflammation could initiate the genesis of many age-associated chronic illnesses such as autoimmune and neurodegenerative diseases or tumors/cancers. In this perspective 'birds' eye' view of major interrelated co-morbidity risk factors that participate in biological shifts of growth-arresting ('tumoricidal') or growth-promoting ('tumorigenic') properties of immune cells and the genesis of chronic inflammatory diseases and cancer will be discussed. Persistent inflammation is perhaps a common denominator in the genesis of nearly all age-associated health problems or cancer. Future challenging opportunities for diagnosis, prevention, and/or therapy of chronic illnesses will require an integrated understanding and identification of developmental phases of inflammation-induced immune dysfunction and age-associated hormonal and physiological readjustments of organ systems. Designing suitable cohort studies to establish the oxido-redox status of adults may prove to be an effective strategy in assessing individual's health toward developing personal medicine for healthy aging.

Speckle imaging of active galactic nuclei: NGC 1068 and NGC 4151

NASA Astrophysics Data System (ADS)

Ebstein, Steven Michael

High resolution images of NGC 1068 and NGC 4151 in the 5007 A line and the nearby continuum produced from data taken with the PAPA photon counting imaging detector using the technique of speckle imaging are presented. The images show an unresolved core of 5007 A emission in the middle of an extended emission region. The extended emission tends to lie alongside the subarcsecond radio structure. In NGC 4151, the extended emission comes from a nearly linear structure extending on both sides of the unresolved core. In NGC 1068, the extended emission is concentrated in lobes lying to the unresolved core but the emission is concentrated in lobes lying to either side of the major axis. The continuum of NGC 4151 is spatially unresolved. The continuum of NGC 1068 is extended approx. 1 in to the SW of the center of the 5007 A emission. Certain aspects of the PAPA detector are discussed, including the variable threshold discriminators that track the image intensifier pulse height and the camera artifacts. The data processing is described in detail.

Media literacy as a violence-prevention strategy: a pilot evaluation.

PubMed

Webb, Theresa; Martin, Kathryn; Afifi, Abdelmonem A; Kraus, Jess

2010-09-01

Youth violence is a major unresolved public health problem in the United States and media exposure to violence is a synergistic source of this national problem. One media literacy curriculum designed specifically to address this issue is Beyond Blame: Challenging Violence in the Media. The purpose of this pilot study was to examine the curriculum's feasibility as a full-scale intervention. Intervention and control groups were similar with respect to knowledge of the Beyond Blame curriculum at baseline. Intervention students scored much higher on the posttest compared with the control students. The majority (90.2%) of the intervention students reported a significant increase in pre- to posttest score compared with only 18.8% of the control students (p < .0001). The magnitude of the score increase for intervention students was much greater than those in the control group. Several intervention students (N = 49; 19.9%) improved their score by 12 or more points compared with the control students who showed only a 1- to 7-point score increase (N = 3; 18.8%; p < .0001). The pre-and posttest scores were similar for males and females. Three of the six intervention classrooms scored higher on both the pretest and posttest compared with the other three classrooms.

Stochastic Optimal Prediction with Application to Averaged Euler Equations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bell, John; Chorin, Alexandre J.; Crutchfield, William

Optimal prediction (OP) methods compensate for a lack of resolution in the numerical solution of complex problems through the use of an invariant measure as a prior measure in the Bayesian sense. In first-order OP, unresolved information is approximated by its conditional expectation with respect to the invariant measure. In higher-order OP, unresolved information is approximated by a stochastic estimator, leading to a system of random or stochastic differential equations. We explain the ideas through a simple example, and then apply them to the solution of Averaged Euler equations in two space dimensions.

Ensemble Kalman filters for dynamical systems with unresolved turbulence

DOE Office of Scientific and Technical Information (OSTI.GOV)

Grooms, Ian, E-mail: grooms@cims.nyu.edu; Lee, Yoonsang; Majda, Andrew J.

Ensemble Kalman filters are developed for turbulent dynamical systems where the forecast model does not resolve all the active scales of motion. Coarse-resolution models are intended to predict the large-scale part of the true dynamics, but observations invariably include contributions from both the resolved large scales and the unresolved small scales. The error due to the contribution of unresolved scales to the observations, called ‘representation’ or ‘representativeness’ error, is often included as part of the observation error, in addition to the raw measurement error, when estimating the large-scale part of the system. It is here shown how stochastic superparameterization (amore » multiscale method for subgridscale parameterization) can be used to provide estimates of the statistics of the unresolved scales. In addition, a new framework is developed wherein small-scale statistics can be used to estimate both the resolved and unresolved components of the solution. The one-dimensional test problem from dispersive wave turbulence used here is computationally tractable yet is particularly difficult for filtering because of the non-Gaussian extreme event statistics and substantial small scale turbulence: a shallow energy spectrum proportional to k{sup −5/6} (where k is the wavenumber) results in two-thirds of the climatological variance being carried by the unresolved small scales. Because the unresolved scales contain so much energy, filters that ignore the representation error fail utterly to provide meaningful estimates of the system state. Inclusion of a time-independent climatological estimate of the representation error in a standard framework leads to inaccurate estimates of the large-scale part of the signal; accurate estimates of the large scales are only achieved by using stochastic superparameterization to provide evolving, large-scale dependent predictions of the small-scale statistics. Again, because the unresolved scales contain so much energy, even an accurate estimate of the large-scale part of the system does not provide an accurate estimate of the true state. By providing simultaneous estimates of both the large- and small-scale parts of the solution, the new framework is able to provide accurate estimates of the true system state.« less

[Flexible endoscope in thoracic surgery: CITES or cVATS?].

PubMed

Assouad, J; Fénane, H; Masmoudi, H; Giol, M; Karsenti, A; Gounant, V; Grunenwald, D

2013-10-01

Early pain and persistent parietal disorders remains a major unresolved problem in thoracic surgery. Thoracotomy and the use of multiple ports in most Video Assisted Thoracic Surgery (VATS) procedures are the major cause of this persistent pain. For the last decade, a few publications describing the use of either single incision VATS and cervical thoracic approaches have been reported without significant results in comparison with current used techniques. Intercostals compression during surgery and early after by intercostals chest tube placement, are probably the major cause of postoperative pain. Flexible endoscope is currently used in several surgeries and will take more and more importance in our daily use in thoracic surgery. Instrument flexibility allows its use through minimally invasive approaches and offers a very interesting intra-thoracic navigation. We describe here the first use in France of a flexible endoscope in thoracic surgery through a single cervical incision to perform simultaneous exploration and biopsies of the mediastinum and right pleura using the original approach of Cervical Incision Thoracic Endoscopic Surgery (CITES). Copyright © 2013 Elsevier Masson SAS. All rights reserved.

Stress in childhood

MedlinePlus

... body changes, in both boys and girls Seeing parents go through a divorce or separation Money problems in the family Living in an unsafe home or neighborhood SIGNS OF UNRESOLVED STRESS IN ... lead parents to suspect an increased stress level is present. ...

Nuclear Power; Past, present and future

NASA Astrophysics Data System (ADS)

Elliott, David

2017-04-01

This book looks at the early history of nuclear power, at what happened next, and at its longer-term prospects. The main question is: can nuclear power overcome the problems that have emerged? It was once touted as the ultimate energy source, freeing mankind from reliance on dirty, expensive fossil energy. Sixty years on, nuclear only supplies around 11.5% of global energy and is being challenged by cheaper energy options. While the costs of renewable sources, like wind and solar, are falling rapidly, nuclear costs have remained stubbornly high. Its development has also been slowed by a range of other problems, including a spate of major accidents, security concerns and the as yet unresolved issue of what to do with the wastes that it produces. In response, a new generation of nuclear reactors is being developed, many of them actually revised versions of the ideas first looked at in the earlier phase. Will this new generation of reactors bring nuclear energy to the forefront of energy production in the future?

Up from the beach: medical waste disposal rules!

PubMed

Francisco, C J

1989-07-01

The recent incidents of floating debris, garbage, wood, and medical waste on our nation's beaches have focused public attention on waste management problems. The handling and disposal of solid waste remains a major unresolved national dilemma. Increased use of disposables by all consumers, including the medical profession, and the increasing costs of solid waste disposal options have aggravated the solid waste situation. Medical waste found on beaches in the summer of 1988 could have been generated by a number of sources, including illegal dumping; sewer overflow; storm water runoff; illegal drug users; and inadequate handling of solid waste at landfills and coastal transfer facilities, which receive waste from doctors' offices, laboratories, and even legitimate home users of syringes. As officials from New Jersey have determined, the beach garbage is no mystery. It's coming from you and me. In response to the perceived medical waste disposal problem, various state and federal agencies have adopted rules to regulate and control the disposal of medical waste. This article outlines the more significant rules that apply to medical waste.

Conversion of magnetic energy in the magnetic reconnection layer of a laboratory plasma

DOE PAGES

Yamada, Masaaki; Yoo, Jongsoo; Jara-Almonte, Jonathan; ...

2014-09-10

Magnetic reconnection, in which magnetic field lines break and reconnect to change their topology, occurs throughout the universe. The essential feature of reconnection is that it energizes plasma particles by converting magnetic energy. Despite the long history of reconnection research, how this energy conversion occurs remains a major unresolved problem in plasma physics. Here we report that the energy conversion in a laboratory reconnection layer occurs in a much larger region than previously considered. The mechanisms for energizing plasma particles in the reconnection layer are identified, and a quantitative inventory of the converted energy is presented for the first timemore » in a well defined reconnection layer; 50% of the magnetic energy is converted to particle energy, 2/3 of which transferred to ions and 1/3 to electrons. Our results are compared with simulations and space measurements, for a key step toward resolving one of the most important problems in plasma physics.« less

Reduction of Non-uniform Beam Filling Effects by Vertical Decorrelation: Theory and Simulations

NASA Technical Reports Server (NTRS)

Short, David; Nakagawa, Katsuhiro; Iguchi, Toshio

2013-01-01

Algorithms for estimating precipitation rates from spaceborne radar observations of apparent radar reflectivity depend on attenuation correction procedures. The algorithm suite for the Ku-band precipitation radar aboard the Tropical Rainfall Measuring Mission satellite is one such example. The well-known problem of nonuniform beam filling is a source of error in the estimates, especially in regions where intense deep convection occurs. The error is caused by unresolved horizontal variability in precipitation characteristics such as specific attenuation, rain rate, and effective reflectivity factor. This paper proposes the use of vertical decorrelation for correcting the nonuniform beam filling error developed under the assumption of a perfect vertical correlation. Empirical tests conducted using ground-based radar observations in the current simulation study show that decorrelation effects are evident in tilted convective cells. However, the problem of obtaining reasonable estimates of a governing parameter from the satellite data remains unresolved.

Contextual E-Learning Evaluation: A Preliminary Framework

ERIC Educational Resources Information Center

Voigt, Christian; Swatman, Paula M. C.

2004-01-01

The evaluation of solutions is a major unresolved issue for all those involved in e-learning. In this paper we illustrate the importance of context by means of a qualitative comparison of two e-learning prototype implementations--an action research case undertaken in conjunction with a major German insurance company; and a more experimental…

False Signs and the Non-Specificity of Theory of Mind: Evidence that Preschoolers Have General Difficulties in Understanding Representations

ERIC Educational Resources Information Center

Leekam, Susan; Perner, Josef; Healey, Laura; Sewell, Claire

2008-01-01

The discovery that 3-year-old children have difficulties understanding false belief has fuelled two decades of research directed at understanding why children have this problem. One unresolved question is whether false belief problems are due to difficulties with mental or representational aspects of mental states. This question has implications…

Teaching Mathematical Problem-Solving with the Brain in Mind: How Can Opening a Closed Problem Help?

ERIC Educational Resources Information Center

Ambrus, András

2014-01-01

In the international literature, increasing numbers of articles and books are published about teaching and learning, with the brain in mind. For a long time, I have been sceptical about this question. However, seeing many unresolved issues in the teaching and learning of mathematics, I slowly started to study the relevant literature and have…

A sibling adoption study of adult attachment: The influence of shared environment on attachment states of mind

PubMed Central

Caspers, Kristin; Yucuis, Rebecca; Troutman, Beth; Arndt, Stephan; Langbehn, Douglas

2009-01-01

This study extends existing research investigating sibling concordance on attachment by examining concordance for adult attachment in a sample of 126 genetically unrelated sibling pairs. The Adult Attachment Interview (George, Kaplan, & Main, 1985; Main, Goldwyn, & Hesse, 2003) was used to assess states of mind with regard to attachment. The average age of the participants was 39 years old. The distribution of attachment classifications was independent of adoptive status. Attachment concordance rates were unassociated with gender concordance and sibling age difference. Concordance for autonomous/non-autonomous classifications was significant at 61% as was concordance for primary classifications at 53%. The concordance rate for not-unresolved/unresolved was non-significant at 67%. Our findings demonstrate similarity of working models of attachment between siblings independent of genetic relatedness between siblings and generations (i.e., parent and child). These findings extend previous research by further implicating shared environment as a major influence on sibling similarities on organized patterns of attachment in adulthood. The non-significant concordance for the unresolved classification suggests that unresolved loss or trauma may be less influenced by shared environment and more likely to be influenced by post-childhood experiences or genetic factors. PMID:18049934

Complement Activation and STAT4 Expression Are Associated with Early Inflammation in Diabetic Wounds

PubMed Central

Cunnion, Kenji M.; Krishna, Neel K.; Pallera, Haree K.; Pineros-Fernandez, Angela; Rivera, Magdielis Gregory; Hair, Pamela S.; Lassiter, Brittany P.; Huyck, Ryan; Clements, Mary A.; Hood, Antoinette F.; Rodeheaver, George T.; Nadler, Jerry L.; Dobrian, Anca D.

2017-01-01

Diabetic non-healing wounds are a major clinical problem. The mechanisms leading to poor wound healing in diabetes are multifactorial but unresolved inflammation may be a major contributing factor. The complement system (CS) is the most potent inflammatory cascade in humans and contributes to poor wound healing in animal models. Signal transducer and activator of transcription 4 (STAT4) is a transcription factor expressed in immune and adipose cells and contributes to upregulation of some inflammatory chemokines and cytokines. Persistent CS and STAT4 expression in diabetic wounds may thus contribute to chronic inflammation and delayed healing. The purpose of this study was to characterize CS and STAT4 in early diabetic wounds using db/db mice as a diabetic skin wound model. The CS was found to be activated early in the diabetic wounds as demonstrated by increased anaphylatoxin C5a in wound fluid and C3-fragment deposition by immunostaining. These changes were associated with a 76% increase in nucleated cells in the wounds of db/db mice vs. controls. The novel classical CS inhibitor, Peptide Inhibitor of Complement C1 (PIC1) reduced inflammation when added directly or saturated in an acellular skin scaffold, as reflected by reduced CS components and leukocyte infiltration. A significant increase in expression of STAT4 and the downstream macrophage chemokine CCL2 and its receptor CCR2 were also found in the early wounds of db/db mice compared to non-diabetic controls. These studies provide evidence for two new promising targets to reduce unresolved inflammation and to improve healing of diabetic skin wounds. PMID:28107529

Analyzing γ rays of the Galactic Center with deep learning

NASA Astrophysics Data System (ADS)

Caron, Sascha; Gómez-Vargas, Germán A.; Hendriks, Luc; Ruiz de Austri, Roberto

2018-05-01

We present the application of convolutional neural networks to a particular problem in gamma ray astronomy. Explicitly, we use this method to investigate the origin of an excess emission of GeV γ rays in the direction of the Galactic Center, reported by several groups by analyzing Fermi-LAT data. Interpretations of this excess include γ rays created by the annihilation of dark matter particles and γ rays originating from a collection of unresolved point sources, such as millisecond pulsars. We train and test convolutional neural networks with simulated Fermi-LAT images based on point and diffuse emission models of the Galactic Center tuned to measured γ ray data. Our new method allows precise measurements of the contribution and properties of an unresolved population of γ ray point sources in the interstellar diffuse emission model. The current model predicts the fraction of unresolved point sources with an error of up to 10% and this is expected to decrease with future work.

Parameterizing unresolved obstacles with source terms in wave modeling: A real-world application

NASA Astrophysics Data System (ADS)

Mentaschi, Lorenzo; Kakoulaki, Georgia; Vousdoukas, Michalis; Voukouvalas, Evangelos; Feyen, Luc; Besio, Giovanni

2018-06-01

Parameterizing the dissipative effects of small, unresolved coastal features, is fundamental to improve the skills of wave models. The established technique to deal with this problem consists in reducing the amount of energy advected within the propagation scheme, and is currently available only for regular grids. To find a more general approach, Mentaschi et al., 2015b formulated a technique based on source terms, and validated it on synthetic case studies. This technique separates the parameterization of the unresolved features from the energy advection, and can therefore be applied to any numerical scheme and to any type of mesh. Here we developed an open-source library for the estimation of the transparency coefficients needed by this approach, from bathymetric data and for any type of mesh. The spectral wave model WAVEWATCH III was used to show that in a real-world domain, such as the Caribbean Sea, the proposed approach has skills comparable and sometimes better than the established propagation-based technique.

Postscript: Problems With the Security Motivation Model Remain Largely Unresolved: Response to Woody and Szechtman (2005)

ERIC Educational Resources Information Center

Taylor, Steven; McKay, Dean; Abramowitz, Jonathan S.

2005-01-01

This paper comments on the response offered by Szechtman and Woody to Taylor et al's initial comments on Szechtman and Woody's original article. Taylor et al highlight one problem with their model that Woody and Szechtman seem to think is unimportant: the treatment relevance of their model. The analogy of aspirin and colds was used, suggesting…

Generalized Radiative Transfer as an Efficient Computational Tool for Spatial and/or Spectral Integration over Unresolved Variability in Multi-Angle Observations

NASA Astrophysics Data System (ADS)

Davis, A. B.; Xu, F.; Diner, D. J.

2017-12-01

Two perennial problems in applied theoretical and computational radiative transfer (RT) are: (1) the impact of unresolved spatial variability on large-scale fluxes (in climate models) or radiances (in remote sensing); and (2) efficient-yet-accurate estimation of broadband spectral integrals in radiant energy budget estimation as well as in remote sensing, in particular, of trace gases.Generalized RT (GRT) is a modification of classic RT in an optical medium with uniform extinction where Beer's exponential law for direct transmission is replaced by a monotonically decreasing function with a slower power-law decay. In a convenient parameterized version of GRT, mean extinction replaces the uniform value and just one new property is introduced. As a non-dimensional metric for the unresolved variability, we use the square of the mean extinction coefficient divided by its variance. This parameter is also the exponent of the power-law tail of the modified transmission law.This specific form of sub-exponential transmission has explored for almost two decades in application to spatial variability in the presence of long-range correlations, much like in turbulent media such as clouds, with a focus on multiple scattering. It has also been proposed by Conley and Collins (JQSRT, 112, 1525-, 2011) to improve on the standard (weak-line) implementation of the correlated-k technique for efficient spectral integration.We have merged these two applications within a rigorous formulation of the combined problem, and solve the new integral RT equations in the single-scattering limit. The result is illustrated by addressing practical problems in multi-angle remote sensing of aerosols using the O2 A-band, an emerging methodology for passive profiling of coarse aerosols and clouds.

Research projects lead by the USDA Cranberry Entomology Laboratory (CEL)

USDA-ARS?s Scientific Manuscript database

1. Newly discovered native nematode species represent bio-insecticides (grad student project) a. Problems being addressed: Issues over flea beetle control; unresolved questions over pesticide use during bloom. b. Discoveries: at least two native nematodes species new to science have been discovered ...

Care at End of Life Influences Grief: A Nationwide Long-Term Follow-Up among Young Adults Who Lost a Brother or Sister to Childhood Cancer.

PubMed

Lövgren, Malin; Sveen, Josefin; Nyberg, Tommy; Eilegård Wallin, Alexandra; Prigerson, Holly G; Steineck, Gunnar; Kreicbergs, Ulrika

2018-02-01

A majority of cancer-bereaved siblings report long-term unresolved grief, thus it is important to identify factors that may contribute to resolving their grief. To identify modifiable or avoidable family and care-related factors associated with unresolved grief among siblings two to nine years post loss. This is a nationwide Swedish postal survey. Study-specific questions and the standardized instrument Hospital Anxiety and Depression Scale. Primary outcome was unresolved grief, and family and care-related factors were used as predictors. Cancer-bereaved sibling (N = 174) who lost a brother/sister to childhood cancer during 2000-2007 in Sweden (participation rate 73%). Seventy-three were males and 101 females. The age of the siblings at time of loss was 12-25 years and at the time of the survey between 19 and 33 years. Several predictors for unresolved grief were identified: siblings' perception that it was not a peaceful death [odds ratio (OR): 9.86, 95% confidence interval (CI): 2.39-40.65], limited information given to siblings the last month of life (OR: 5.96, 95% CI: 1.87-13.68), information about the impending death communicated the day before it occurred (OR: 2.73, 95% CI: 1.02-7.33), siblings' avoidance of the doctors (OR: 3.22, 95% CI: 0.75-13.76), and lack of communication with family (OR: 2.86, 95% CI: 1.01-8.04) and people outside the family about death (OR: 5.07, 95% CI: 1.64-15.70). Depressive symptoms (OR: 1.27, 95% CI: 1.12-1.45) and time since loss (two to four years: OR: 10.36, 95% CI: 2.87-37.48 and five to seven years: OR: 8.36, 95% CI: 2.36-29.57) also predicted unresolved grief. Together, these predictors explained 54% of the variance of unresolved grief. Siblings' perception that it was not a peaceful death and poor communication with family, friends, and healthcare increased the risk for unresolved grief among the siblings.

Reflecting on ethical and legal issues in wildlife disease.

PubMed

McCallum, Hamish; Hocking, Barbara Ann

2005-08-01

Disease in wildlife raises a number of issues that have not been widely considered in the bioethical literature. However, wildlife disease has major implications for human welfare. The majority of emerging human infectious diseases are zoonotic: this is, they occur in humans by cross-species transmissions from animal hosts. Managing these diseases often involves balancing concerns with human health against animal welfare and conservation concerns. Many infectious diseases of domestic animals are shared with wild animals, although it is often unclear whether the infection spills over from wild animals to domestic animals or vice versa. Culling is the standard means of managing such diseases, bringing economic considerations, animal welfare and conservation into conflict. Infectious diseases are also major threatening processes in conservation biology and their appropriate management by culling, vaccination or treatment raises substantial animal ethics issues. One particular issue of great significance in Australia is an ongoing research program to develop genetically modified pathogens to control vertebrate pests including rabbits, foxes and house mice. Release of any self-replicating GMO vertebrate pathogen gives rise to a whole series of ethical questions. We briefly review current Australian legal responses to these problems. Finally, we present two unresolved problems of general importance that are exemplified by wildlife disease. First, to what extent can or should 'bioethics' be broadened beyond direct concerns with human welfare to animal welfare and environmental welfare? Second, how should the irreducible uncertainty of ecological systems be accounted for in ethical decision making?

Toward the Management of Heterosexual Jealousy

ERIC Educational Resources Information Center

Francis, Janice L.

1977-01-01

Despite the apparent universality of the jealousy phenomenon, communication in couples is inhibited by the social disapproval associated with its occurrance, and consequently discrepancies such as those evidenced in this study may pass entirely unobserved. As a result, jealousy problems remain unresolved and may serve to trigger further…

Unresolved versus resolved: testing the validity of young simple stellar population models with VLT/MUSE observations of NGC 3603

NASA Astrophysics Data System (ADS)

Kuncarayakti, H.; Galbany, L.; Anderson, J. P.; Krühler, T.; Hamuy, M.

2016-09-01

Context. Stellar populations are the building blocks of galaxies, including the Milky Way. The majority, if not all, extragalactic studies are entangled with the use of stellar population models given the unresolved nature of their observation. Extragalactic systems contain multiple stellar populations with complex star formation histories. However, studies of these systems are mainly based upon the principles of simple stellar populations (SSP). Hence, it is critical to examine the validity of SSP models. Aims: This work aims to empirically test the validity of SSP models. This is done by comparing SSP models against observations of spatially resolved young stellar population in the determination of its physical properties, that is, age and metallicity. Methods: Integral field spectroscopy of a young stellar cluster in the Milky Way, NGC 3603, was used to study the properties of the cluster as both a resolved and unresolved stellar population. The unresolved stellar population was analysed using the Hα equivalent width as an age indicator and the ratio of strong emission lines to infer metallicity. In addition, spectral energy distribution (SED) fitting using STARLIGHT was used to infer these properties from the integrated spectrum. Independently, the resolved stellar population was analysed using the colour-magnitude diagram (CMD) to determine age and metallicity. As the SSP model represents the unresolved stellar population, the derived age and metallicity were tested to determine whether they agree with those derived from resolved stars. Results: The age and metallicity estimate of NGC 3603 derived from integrated spectroscopy are confirmed to be within the range of those derived from the CMD of the resolved stellar population, including other estimates found in the literature. The result from this pilot study supports the reliability of SSP models for studying unresolved young stellar populations. Based on observations collected at the European Organisation for Astronomical Research in the Southern Hemisphere under ESO programme 60.A-9344.

A Perspective of the Science and Mission Challenges in Aeronomy

NASA Technical Reports Server (NTRS)

Spann, James F.

2010-01-01

There are significant fundamental problems for which aeronomy can provide solutions and a critical role in applied science and space weather that only aeronomy can address. Examples of unresolved problems include the interaction of neutral and charged, the role of mass and energy transfer across Earth's interface with space, and the predictability of ionospheric density and composition variability. These and other problems impact the productivity of space assets and thus have a tangible applied dimension. This talk will explore open science problems and barriers to potential mission solutions in an era of constrained resources.

Inclusion and Comprehensive School Reform: Lessons from the Field

ERIC Educational Resources Information Center

Bain, Alan; Lancaster, Julie

2006-01-01

Sustaining comprehensive secondary school reform (CSR) represents an immensely difficult and unresolved challenge for the field. The problems associated with CSR are of significant concern to proponents of inclusion given that more responsive schools and classrooms are connected to, if not dependent upon, the success of broader school reform…

Curriculum Theory, Curriculum Policy and the Problem of Ill-Disciplined Thinking

ERIC Educational Resources Information Center

Harris, Richard; Burn, Katharine

2011-01-01

This paper examines the implications of policy fracture and arms length governance within the decision-making processes currently shaping curriculum design within the English education system. In particular, it argues that an unresolved "ideological fracture" at the government level has been passed down to school leaders whose response…

Investigating the Boron Requirement of Plants.

ERIC Educational Resources Information Center

Bohnsack, Charles W.

1991-01-01

This article describes a simple and rapid method for using summer squash to investigate born deficiency in plants. Author asserts that students are likely to feel challenged by laboratory exercises and projects that focus on the role boron plays in plant growth because it is an unresolved problem in biology. (PR)

Sexuality and the Curriculum: The Politics and Practices of Sexuality Education. Critical Issues in the Curriculum.

ERIC Educational Resources Information Center

Sears, James T., Ed.

This book of essays explores the explicit and hidden curriculum of sexuality from kindergarten through college. The 15 interrelated essays challenge conventional assumptions regarding sexuality and the curriculum by applying non-traditional perspectives to traditionally unresolved problems while proposing specific curricular strategies and…

Traumatic Brain Injury and Vocational Rehabilitation.

ERIC Educational Resources Information Center

Corthell, David W., Ed.

Intended to serve as a resource guide on traumatic brain injury for rehabilitation practitioners, the book's 10 chapters are grouped into sections which provide an introduction and examine aspects of evaluation, treatment and placement planning, and unresolved issues. Chapters have the following titles and authors: "Scope of the Problem" (Marilyn…

"My Mom and Her Boyfriend Fuss": A Five-Minute RAP

ERIC Educational Resources Information Center

Laursen, Erik K.; Whindleton, Kendra

2012-01-01

Unresolved issues from home often spill over into behavior problems at school. This article discusses the five-minute RAP techniques: (1) connect; (2) clarify; and (3) restore. The authors present a case study wherein this brief restorative intervention had been a successful alternative to punishment and exclusion.

The Aging Cardiovascular System: Understanding It at the Cellular and Clinical Levels.

PubMed

Paneni, Francesco; Diaz Cañestro, Candela; Libby, Peter; Lüscher, Thomas F; Camici, Giovanni G

2017-04-18

Cardiovascular disease (CVD) presents a great burden for elderly patients, their caregivers, and health systems. Structural and functional alterations of vessels accumulate throughout life, culminating in increased risk of developing CVD. The growing elderly population worldwide highlights the need to understand how aging promotes CVD in order to develop new strategies to confront this challenge. This review provides examples of some major unresolved clinical problems encountered in daily cardiovascular practice as we care for elderly patients. Next, the authors summarize the current understanding of the mechanisms implicated in cardiovascular aging, and the potential for targeting novel pathways implicated in endothelial dysfunction, mitochondrial oxidative stress, chromatin remodeling, and genomic instability. Lastly, the authors consider critical aspects of vascular repair, including autologous transplantation of bone marrow-derived stem cells in elderly patients. Copyright © 2017 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

Imaging the elusive H-poor gas in planetary nebulae with large abundance discrepancy factors

NASA Astrophysics Data System (ADS)

García-Rojas, Jorge; Corradi, Romano L. M.; Boffin, Henri M. J.; Monteiro, Hektor; Jones, David; Wesson, Roger; Cabrera-Lavers, Antonio; Rodríguez-Gil, Pablo

2017-10-01

The discrepancy between abundances computed using optical recombination lines (ORLs) and collisionally excited lines (CELs) is a major, unresolved problem with significant implications for the determination of chemical abundances throughout the Universe. In planetary nebulae (PNe), the most common explanation for the discrepancy is that two different gas phases coexist: a hot component with standard metallicity, and a much colder plasma enhanced in heavy elements. This dual nature is not predicted by mass loss theories, and direct observational support for it is still weak. In this work, we present our recent findings that demonstrate that the largest abundance discrepancies are associated with close binary central stars. OSIRIS-GTC tunable filter imaging of the faint O ii ORLs and MUSE-VLT deep 2D spectrophotometry confirm that O ii ORL emission is more centrally concentrated than that of [Oiii] CELs and, therefore, that the abundance discrepancy may be closely linked to binary evolution.

Atomic electron tomography: 3D structures without crystals

DOE PAGES

Miao, Jianwei; Ercius, Peter; Billinge, S. J. L.

2016-09-23

Crystallography has been fundamental to the development of many fields of science over the last century. However, much of our modern science and technology relies on materials with defects and disorders, and their three-dimensional (3D) atomic structures are not accessible to crystallography. One method capable of addressing this major challenge is atomic electron tomography. By combining advanced electron microscopes and detectors with powerful data analysis and tomographic reconstruction algorithms, it is now possible to determine the 3D atomic structure of crystal defects such as grain boundaries, stacking faults, dislocations, and point defects, as well as to precisely localize the 3Dmore » coordinates of individual atoms in materials without assuming crystallinity. In this work, we review the recent advances and the interdisciplinary science enabled by this methodology. We also outline further research needed for atomic electron tomography to address long-standing unresolved problems in the physical sciences.« less

Electroconvulsive therapy and its different indications

PubMed Central

Baghai, Thomas C.; Möller, Hans-Jürgen

2008-01-01

In spite of recent developments in the pharmacotherapy of depressive disorders, the delay until clinical improvement can be achieved, and the considerable rate of nonresponse and nonremission, are major problems which remain unresolved. Electroconvulsive therapy (ECT) is a nonpharmacoloqic bioloqical treatment which has been proven to be a highly effective treatment option, predominantly for depression, but also for schizophrenia and other indications. Though there is a lack of controlled investigations on long-term treatments, ECT can also be used for relapse prevention during maintenance therapies. The safety and tolerabitity of electroconvulsive treatment have been enhanced by the use of modified stimulation techniques and by progress in modern anesthesia. Thus, today a safe treatment can also be offered to patients with higher somatic risks, ECT still represents an important option, especially in the therapy of treatmentresistant psychiatric disorders after medication treatment failures. Earlier consideration of ECT may reduce the rate of chronic and difficult-to-treat psychiatric disorders. PMID:18472488

Self-consistent molecular dynamics calculation of diffusion in higher n-alkanes.

PubMed

Kondratyuk, Nikolay D; Norman, Genri E; Stegailov, Vladimir V

2016-11-28

Diffusion is one of the key subjects of molecular modeling and simulation studies. However, there is an unresolved lack of consistency between Einstein-Smoluchowski (E-S) and Green-Kubo (G-K) methods for diffusion coefficient calculations in systems of complex molecules. In this paper, we analyze this problem for the case of liquid n-triacontane. The non-conventional long-time tails of the velocity autocorrelation function (VACF) are found for this system. Temperature dependence of the VACF tail decay exponent is defined. The proper inclusion of the long-time tail contributions to the diffusion coefficient calculation results in the consistency between G-K and E-S methods. Having considered the major factors influencing the precision of the diffusion rate calculations in comparison with experimental data (system size effects and force field parameters), we point to hydrogen nuclear quantum effects as, presumably, the last obstacle to fully consistent n-alkane description.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Miao, Jianwei; Ercius, Peter; Billinge, S. J. L.

Crystallography has been fundamental to the development of many fields of science over the last century. However, much of our modern science and technology relies on materials with defects and disorders, and their three-dimensional (3D) atomic structures are not accessible to crystallography. One method capable of addressing this major challenge is atomic electron tomography. By combining advanced electron microscopes and detectors with powerful data analysis and tomographic reconstruction algorithms, it is now possible to determine the 3D atomic structure of crystal defects such as grain boundaries, stacking faults, dislocations, and point defects, as well as to precisely localize the 3Dmore » coordinates of individual atoms in materials without assuming crystallinity. In this work, we review the recent advances and the interdisciplinary science enabled by this methodology. We also outline further research needed for atomic electron tomography to address long-standing unresolved problems in the physical sciences.« less

"Imitation of similar beings": social mimesis as an argument in evolutionary theory around 1900.

PubMed

Willer, Stefan

2009-01-01

The article analyzes imitation as both a fascinating and irritating phenomenon in "classical" evolutionary theory. Evolutionists situate imitation on the threshold between the natural and the socio-cultural, hence between the animal and the human. This intermediate position can be regarded as a symptom for the unresolved and maybe unresolvable problem of intentionality and teleology in nature. To elaborate this problem, I examine the ways in which imitation was conceived of by the German Africologist Wilhelm Bleek in his treatise On the Origin of Language and by Charles Darwin in The Descent of Man. Bleek and Darwin share a high esteem of imitation, which they see as the mainspring of human mental capacities, including language. But at the same time, imitation for them is the epitome of a low level of consciousness, embodied in the figures of the idiot, the savage, and the ape. Thus, the problem of similarity comes to the fore: similarity produced by imitation, but also being at the basis of every act of imitation. This problem is further evidenced with a side glance on Darwin's remarks about mimicry in The Origin of Species. The article closes with a literary reading of Franz Kafka's Report to an Academy, in which imitation and similarity represent survival strategies and motivate a strange shift from ape to man.

Uterine influences on conceptus development in fertility-classified heifers

USDA-ARS?s Scientific Manuscript database

A major unresolved issue is how the uterus influences infertility and subfertility in cattle. Serial embryo transfer was previously used to classify heifers as high fertile (HF), subfertile (SF), or infertile (IF). To assess pregnancy loss in those animals, two in vivo produced embryos were transfer...

Spectral-element simulations of wave propagation in complex exploration-industry models: Mesh generation and forward simulations

NASA Astrophysics Data System (ADS)

Nissen-Meyer, T.; Luo, Y.; Morency, C.; Tromp, J.

2008-12-01

Seismic-wave propagation in exploration-industry settings has seen major research and development efforts for decades, yet large-scale applications have often been limited to 2D or 3D finite-difference, (visco- )acoustic wave propagation due to computational limitations. We explore the possibility of including all relevant physical signatures in the wavefield using the spectral- element method (SPECFEM3D, SPECFEM2D), thereby accounting for acoustic, (visco-)elastic, poroelastic, anisotropic wave propagation in meshes which honor all crucial discontinuities. Mesh design is the crux of the problem, and we use CUBIT (Sandia Laboratories) to generate unstructured quadrilateral 2D and hexahedral 3D meshes for these complex background models. While general hexahedral mesh generation is an unresolved problem, we are able to accommodate most of the relevant settings (e.g., layer-cake models, salt bodies, overthrusting faults, and strong topography) with respectively tailored workflows. 2D simulations show localized, characteristic wave effects due to these features that shall be helpful in designing survey acquisition geometries in a relatively economic fashion. We address some of the fundamental issues this comprehensive modeling approach faces regarding its feasibility: Assessing geological structures in terms of the necessity to honor the major structural units, appropriate velocity model interpolation, quality control of the resultant mesh, and computational cost for realistic settings up to frequencies of 40 Hz. The solution to this forward problem forms the basis for subsequent 2D and 3D adjoint tomography within this context, which is the subject of a companion paper.

Plant invasions in mountains: global lessons for better management

Treesearch

Keith L. McDougall; Anzar A. Khuroo; Lloyd L. Loope; Catherine G. Parks; Anibal Pauchard; Zafar A. Reshi; Ian Rushworth; Christoph Kueffer

2011-01-01

Mountains are one of few ecosystems little affected by plant invasions. However, the threat of invasion is likely to increase because of climate change, greater anthropogenic land use, and continuing novel introductions. Preventive management, therefore, will be crucial but can be difficult to promote when more pressing problems are unresolved and predictions are...

Division: The Sleeping Dragon

ERIC Educational Resources Information Center

Watson, Anne

2012-01-01

Of the four mathematical operators, division seems to not sit easily for many learners. Division is often described as "the odd one out". Pupils develop coping strategies that enable them to "get away with it". So, problems, misunderstandings, and misconceptions go unresolved perhaps for a lifetime. Why is this? Is it a case of "out of sight out…

Marijuana Effects on Human Forgetting Functions

ERIC Educational Resources Information Center

Lane, Scott D.; Cherek, Don R.; Lieving, Lori M.; Tcheremissine, Oleg V.

2005-01-01

It has long been known that acute marijuana administration impairs working memory (e.g., the discrimination of stimuli separated by a delay). The determination of which of the individual components of memory are altered by marijuana is an unresolved problem. Previous human studies did not use test protocols that allowed for the determination of…

Staff Grief Resolution and Care for the Elderly: Artificial Intelligence Analysis.

ERIC Educational Resources Information Center

Seibert, Phyllis M.; Pastorello, Thomas

Literature on health professionals describes the problems associated with unresolved or poorly resolved grief. Previous research has indicated that the most important reason why health professionals stay in their jobs is their relationship to patients. This study examined how nursing home personnel resolve their grief following deaths of clients.…

When Others' Performance Just Isn't Good Enough: Educational Leaders' Framing of Concerns in Private and Public

ERIC Educational Resources Information Center

Sinnema, Claire E. L.; Le Fevre, Deidre; Robinson, Viviane M. J.; Pope, Denyse

2013-01-01

Effective instructional leadership demands that leaders address the inevitable problems and concerns that exist in any educational organization. Unfortunately, much evidence suggests that many important concerns, including teacher performance issues, continue to be unaddressed and unresolved. This article portrays the nature of concerns facing 77…

Teaching for Social Values in Social Studies.

ERIC Educational Resources Information Center

Dunfee, Maxine; Crump, Claudia

A guide for teaching values in social studies takes a positive stand with regard to the importance of values education in the elementary school based on the belief that many personal and societal problems are the results of unresolved value conflicts. It is hypothesized that children who have continuing experiences in value identification,…

Recursive renormalization group theory based subgrid modeling

NASA Technical Reports Server (NTRS)

Zhou, YE

1991-01-01

Advancing the knowledge and understanding of turbulence theory is addressed. Specific problems to be addressed will include studies of subgrid models to understand the effects of unresolved small scale dynamics on the large scale motion which, if successful, might substantially reduce the number of degrees of freedom that need to be computed in turbulence simulation.

School Improvement in High-Capacity Schools: Educational Leadership and Living-Systems Ontology

ERIC Educational Resources Information Center

Mitchell, Coral; Sackney, Larry

2016-01-01

Although school improvement continues to present as an unresolved educational problem, the required changes are relatively straightforward. Essentially, schools need to be retooled with students' experiences and high-quality instruction at the center of the design. In this article, we present the findings of research into the leadership of…

Idiosyncratic Genetic Specificity for Neurolinguistic Systems: A Cause of Atypical or Delayed Language Acquisition.

ERIC Educational Resources Information Center

Lamendella, John T.

The diagnostic problem presented by children without obvious neurological, cognitive, genetic, emotional or environmental basis for their atypical or delayed language development is discussed. One unresolved issue is whether the deficits of such dysphasic children are linguistic or are more fundamental cognitive or perceptuomotor deficits. A…

Causal Indicator Models: Unresolved Issues of Construction and Evaluation

ERIC Educational Resources Information Center

West, Stephen G.; Grimm, Kevin J.

2014-01-01

These authors agree with Bainter and Bollen that causal effects represents a useful measurement structure in some applications. The structure of the science of the measurement problem should determine the model; the measurement model should not determine the science. They also applaud Bainter and Bollen's important reminder that the full…

Improve Governance for Charters

ERIC Educational Resources Information Center

Finn, Chester E., Jr.; Manno, Bruno V.; Wright, Brandon L.

2017-01-01

With 25 years of experience, the charter sector has had enough time to experience a host of unanticipated and unresolved problems related to the complex ways in which charter school governance relates to school leadership. The time has come for the sector to revisit some fundamental decisions about how charter schools and networks are governed,…

Proceedings of the First National Workshop on the Global Weather Experiment: Current Achievements and Future Directions, volume 1

NASA Technical Reports Server (NTRS)

1985-01-01

A summary of the proceedings in which the most important findings stemming from the Global Weather Experiment (GWE) are highlighted, additional key results and recommendations are comered, and the presentations and discussion are summarized. Detailed achievements, unresolved problems, and recommendations are included.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kolda, Christopher

In this talk, I review recent work on using a generalization of the Next-to-Minimal Supersymmetric Standard Model (NMSSM), called the Singlet-extended Minimal Supersymmetric Standard Model (SMSSM), to raise the mass of the Standard Model-like Higgs boson without requiring extremely heavy top squarks or large stop mixing. In so doing, this model solves the little hierarchy problem of the minimal model (MSSM), at the expense of leaving the {mu}-problem of the MSSM unresolved. This talk is based on work published in Refs. [1, 2, 3].

Southeast Asia: Problems and Prospects Held at Washington, DC on 4-5 December 1984.

DTIC Science & Technology

1985-06-01

widespread. Burmese leaders may have sometimes been considered as " embryo Buddhas," but the military leader is equally a part of the Burman tradition. Kings...mentions Aung San as the reincarnation of King Alaungpaya (1752-1 760), the " embryo Buddha" who was as much warrior as religious leader, and Ne Win as...Vietnam which struck Cambodia. ASEAN supports the right of Cambodia to determine its own destiny . This problem is still unresolved because of Vietnam. Only

Determination of Passing Scores on Certification Examinations: An Unresolved Issue.

ERIC Educational Resources Information Center

Karni, Karen R.; Lofsness, Karen G.

1985-01-01

This study examined the results obtained from certification applicants and practitioners on a national certification examination for clinical laboratory scientists (medical technologists), using a modified Angoff procedure to establish the cut-off score. The major question of the investigation concerned whether the cut-off score was appropriate.…

Total Quality Management (TQM): Group Dynamics Workshop

DTIC Science & Technology

1990-05-15

interactions with other OSD decision-making bodies. " Remove barriers /facilitate implementation. " Direct action on unresolved process problems referred...TQM leadership. - Total Quality Management FUNCTIONS: * Translate goals to tangible internal initiatives. " Remove barriers . " Establish and...Quality Management FUNCTIONS: • Identify and remove barriers . " Develop practical process improvements. " Install solutions and measurement systems for

A Case Study Examination of a Successful Community College to University Transition Partnership

ERIC Educational Resources Information Center

Phillips, Karla

2014-01-01

A low rate of successful transition and degree completion for community college (CC) students who intend to complete a baccalaureate through transfer to a four-year university has been an unresolved problem in higher education. With more students entering higher education through CCs, successful CC to university transitions have become a critical…

Differential Labeling of Mental Illness by Social Status: A New Look at an Old Problem

ERIC Educational Resources Information Center

Thoits, Peggy A.

2005-01-01

Whether the higher rates of mental hospitalization and involuntary treatment for marginal social groups are due to differential labeling or simply to the occurrence of higher rates of disorder in these groups remains unresolved. I reexamine this issue with data from the National Comorbidity Survey (N = 5,877) that allow comparisons between…

A Behavioral Economic Reward Index Predicts Drinking Resolutions: Moderation Revisited and Compared with Other Outcomes

ERIC Educational Resources Information Center

Tucker, Jalie A.; Roth, David L.; Vignolo, Mary J.; Westfall, Andrew O.

2009-01-01

Data were pooled from 3 studies of recently resolved community-dwelling problem drinkers to determine whether a behavioral economic index of the value of rewards available over different time horizons distinguished among moderation (n = 30), abstinent (n = 95), and unresolved (n = 77) outcomes. Moderation over 1- to 2-year prospective follow-up…

Prevent-Teach-Reinforce: The School-Based Model of Individualized Positive Behavior Support

ERIC Educational Resources Information Center

Dunlap, Glen; Iovannone, Rose; Kincaid, Donald; Wilson, Kelly; Christiansen, Kathy; Strain, Phillip; English, Carie

2010-01-01

Solve serious behavior challenges in K-8 classrooms with this easy-to-use book, the first practical guide to the research-proven Prevent-Teach-Reinforce (PTR) model. Developed by some of the most respected authorities on positive behavior support, this innovative model gives school-based teams a five-step plan for reducing problems unresolved by…

Unresolved Maternal Attachment Representations, Disrupted Maternal Behavior and Disorganized Attachment in Infancy: Links to Toddler Behavior Problems

ERIC Educational Resources Information Center

Madigan, Sheri; Moran, Greg; Schuengel, Carlo; Pederson, David R.; Otten, Roy

2007-01-01

Background: Attachment theory's original formulation was substantially driven by Bowlby's (1969/1982) quest for a meaningful model of the development of psychopathology. Bowlby posited that aberrant experiences of parenting increase the child's risk of psychopathological outcomes, and that these risks are mediated by the quality of the attachment…

Differentiating Three Conceptualisations of the Relationship between Positive Development and Psychopathology during the Transition to Adulthood

ERIC Educational Resources Information Center

O'Connor, Meredith; Sanson, Ann; Hawkins, Mary T.; Toumbourou, John W.; Letcher, Primrose; Frydenberg, Erica

2011-01-01

The transition to adulthood is characterised by both great potential for positive change and a relatively high incidence of problem outcomes. A multidimensional model of positive development during the transition to adulthood (at 19-20 years) has recently been proposed. However, an unresolved question regarding the nature of positive development…

The international electronics industry.

PubMed

LaDou, J; Rohm, T

1998-01-01

High-technology microelectronics has a major presence in countries such as China, India, Indonesia, and Malaysia, now the third-largest manufacturer of semiconductor chips. The migration of European, Japanese, and American companies accommodates regional markets. Low wage rates and limited enforcement of environmental regulations in developing countries also serve as incentives for the dramatic global migration of this industry. The manufacture of microelectonics products is accompanied by a high incidence of occupational illnesses, which may reflect the widespread use of toxic materials. Metals, photoactive chemicals, solvents, acids, and toxic gases are used in a wide variety of combinations and workplace settings. The industry also presents problems of radiation exposure and various occupational stressors, including some unresolved ergonomic issues. The fast-paced changes of the technology underlying this industry, as well as the stringent security precautions, have added to the difficulty of instituting proper health and safety measures. Epidemiologic studies reveal an alarming increase in spontaneous abortions among cleanroom manufacturing workers; no definitive study has yet identified its cause. Other health issues, including occupational cancer, are yet to be studied. The microelectronics industry is a good example of an industry that is exported to many areas of the world before health and safety problems are properly addressed and resolved.

Unresolved mourning, supernatural beliefs and dissociation: a mediation analysis.

PubMed

Thomson, Paula; Jaque, S Victoria

2014-01-01

Unresolved mourning is marked by disorganized behavior and states of mind. In this study, we speculated that pathological dissociation would mediate the effects of unresolved mourning on supernatural beliefs. This hypothesis was determined based on findings that indicate an association between higher levels of dissociation, stronger beliefs in the supernatural and unresolved mourning. We examined two groups of participants, one classified as non-unresolved (non-U) (n = 56) and the other as unresolved (n = 26) (U) with respect to past loss/trauma as measured by the Adult Attachment Interview (AAI). Two self-report instruments were administered to measure supernatural beliefs and dissociation. As hypothesized, the multivariate analysis of variance indicated mean differences between the two groups. The unresolved group had greater belief in the supernatural and more pathological dissociative processes. The mediation analysis demonstrated that pathological dissociation fully mediated the effects of unresolved mourning on supernatural beliefs.

Franchise competition in the electric utility industry

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vince, C.A.; Fogel, J.C.

Franchise competition is - and should be - an integral part of enhanced competition. It serves the traditional goal of encouraging lower costs through the threat of takeover or purchase. However, the issue of utility recovery for stranded costs stands as a major unresolved question affecting customers` ability to partake of this central aspect of competition.

Equity in Education: Opportunities and Challenges In A Changing Sri Lanka

ERIC Educational Resources Information Center

Sedere, Upali M.

2010-01-01

Equity is a major concern for all development actors. Although Sri Lanka has successfully addressed equity issues in education sector there are unresolved factors and variables those perpetuate inequity. There are emerging new equity issues those that Sri Lanka needs to address. The changing population dynamics and the huge middle class population…

Multiple polyploidy events in the early radiation of nodulating and non-nodulating legumes

USDA-ARS?s Scientific Manuscript database

Unresolved questions about evolution of the large and diverse legume family include the timing of polyploidy (whole-genome duplication; WGDs) relative to the origin of the major lineages within the Fabaceae and to the origin of symbiotic nitrogen fixation. Previous work has established that a WGD af...

Race Preferences in Children: Insights from South Africa

ERIC Educational Resources Information Center

Shutts, Kristin; Kinzler, Katherine D.; Katz, Rachel C.; Tredoux, Colin; Spelke, Elizabeth S.

2011-01-01

Minority-race children in North America and Europe often show less own-race favoritism than children of the majority (White) race, but the reasons for this asymmetry are unresolved. The present research tested South African children in order to probe the influences of group size, familiarity, and social status on children's race-based social…

The amphibians and reptiles of Mindanao Island, southern Philippines, II: the herpetofauna of northeast Mindanao and adjacent islands.

PubMed

Sanguila, Marites B; Cobb, Kerry A; Siler, Cameron D; Diesmos, Arvin C; Alcala, Angel C; Brown, Rafe M

2016-01-01

We summarize all available amphibian and reptile species distribution data from the northeast Mindanao faunal region, including small islands associated with this subcenter of endemic vertebrate biodiversity. Together with all publicly available historical information from biodiversity repositories, we present new data from several major herpetological surveys, including recently conducted inventories on four major mountains of northeast Mindanao, and adjacent islands of Camiguin Sur, Dinagat, and Siargao. We present species accounts for all taxa, comment on unresolved taxonomic problems, and provide revisions to outdated IUCN conservation status assessments in cases where our new data significantly alter earlier classification status summaries. Together, our comprehensive analysis of this fauna suggests that the greater Mindanao faunal region possesses distinct subcenters of amphibian and reptile species diversity, and that until this area is revisited and its fauna and actually studied, with on-the-ground field work including targeted surveys of species distributions coupled to the study their natural history, our understanding of the diversity and conservation status of southern Philippine herpetological fauna will remain incomplete. Nevertheless, the northeast Mindanao geographical area (Caraga Region) appears to have the highest herpetological species diversity (at least 126 species) of any comparably-sized Philippine faunal subregion.

Patchwork plagiarism--a jigsaw of stolen puzzle pieces.

PubMed

Supak Smolcić, Vesna; Bilić-Zulle, Lidija

2013-01-01

Plagiarism remains at the top in terms of interest to the scientific community. In its many vicious forms, patchwork plagiarism is characterized by numerous unresolved issues and often passes "below the radar" of editors and reviewers. The problem of detecting the complexity of misconduct has been partially resolved by plagiarism detection software. However, interpretation of relevant reports is not always obvious or easy. This article deals with plagiarism in general and patchwork plagiarism in particular, as well as related problems that editors must deal with to maintain the integrity of scientific journals.

The influence of fuelbed properties on moisture drying rates and timelags of longleaf pine litter

Treesearch

Ralph M. Nelson; J. Kevin Hiers

2008-01-01

Fire managers often model pine needles as 1 h timelag fuels, but fuelbed properties may significantly change the rate at which needles exchange moisture with the atmosphere. The problem of determining whether moisture loss from fine fuels is being controlled by individual particles or by the fuelbed remains unresolved. Results from this laboratory experiment indicate...

X-33 Development History

NASA Technical Reports Server (NTRS)

Butrica, Andrew J.

1997-01-01

The problem of dealing with various types of proprietary documents, whether from the Lockheed Martin, the Skunk Works, McDonnell Douglas, Rockwell, and other corporations extant or extinct, remains unresolved. The computerized archive finding aid has over 100 records at present. These records consist of X-33 photographs, press releases, media clippings, and the small number of X-33 project records collected to date.

JPRS Report Soviet Union Political Affairs.

DTIC Science & Technology

1990-07-27

consciousness. Under these conditions the unresolved state of many social, political, and national problems acquired a special urgency . Meanwhile, the...whole. These errors consist entirely of crude distortions of party policy guidelines. And the tragic mistakes of recent years represent depar - tures...kolkhozes, medical institutions and even the soccer team. And so, there is a great discrepancy between words and actions with respect to mutual

Results of arthroscopic treatment in unresolved Osgood-Schlatter disease in athletes.

PubMed

Circi, Esra; Beyzadeoglu, Tahsin

2017-02-01

In this study we aimed to determine outcomes following arthroscopic ossicle excision in athletes with unresolved Osgood-Schlatter disease (OSD). Arthroscopy was performed on 11 patients (11 knees) with OSD between September 2008 and November 2014. Surgical treatment inclusion criteria were determined as: failure of conservative treatment; isolated pain over the tibial tubercle and distal patellar tendon; pain limiting sporting performance at a competitive level. All patients had a documented history of OSD; the mean duration of persistent pain over the tibial tubercle was 15.5 months. The mean age was 23 years. The mean follow-up period was 66.1 months. The mean latency in returning to sports related training activities after the surgery was 6.7 weeks. The mean Kujala patello-femoral score improved from 82.9 points pre-operatively, to 98.5 points at the final follow-up (p < 0.01). The mean Lysholm knee scale score was 87.5 points in the pre-operative period, increasing to a score of 96.9 points at final follow-up (p < 0.01). The mean Tegner activity level score was 7.5 in the pre-operative period, increasing to 8.5 post-operatively (p < 0.01). We investigated the functional outcomes after arthroscopic treatment of unresolved OSD in athletes. All athletes with OSD showed satisfactory functional recovery following arthroscopic treatment. All patients were able to return to the same level of athletic activity. Arthroscopic surgery for unresolved OSD has the major advantage of faster recovery and avoiding damage to the patellar tendon.

Rethinking policy perspectives on childhood stunting: time to formulate a structural and multifactorial strategy

PubMed Central

Mejía‐Guevara, Iván; Krishna, Aditi

2016-01-01

Abstract Stunting and chronic undernutrition among children in South Asia remain a major unresolved global health issue. There are compelling intrinsic and moral reasons to ensure that children attain their optimal growth potential facilitated via promotion of healthy living conditions. Investments in efforts to ensure that children's growth is not faltered also have substantial instrumental benefits in terms of cognitive and economic development. Using the case of India, we critique three prevailing approaches to reducing undernutrition among children: an over‐reliance on macroeconomic growth as a potent policy instrument, a disproportionate focus on interpreting undernutrition as a demand‐side problem and an over‐reliance on unintegrated single‐factorial (one at a time) approaches to policy and research. Using existing evidence, we develop a case for support‐led policy approach with a focus on integrated and structural factors to addressing the problem of undernutrition among children in India. Key messages Eliminating child undernutrition is important from an intrinsic perspective and offers considerable instrumental benefits to individual and society.Evidence suggests that an exclusive reliance on a growth‐mediated strategy to eliminate stunting needs to be reconsidered, suggesting the need for a substantial support‐led strategy.Interpreting and addressing undernutrition as a demand‐side problem with proximal single‐factorial interventions is futile.There is an urgent need to develop interventions that address the broader structural and upstream causes of child undernutrition. PMID:27187918

Inferring Binary and Trinary Stellar Populations in Photometric and Astrometric Surveys

NASA Astrophysics Data System (ADS)

Widmark, Axel; Leistedt, Boris; Hogg, David W.

2018-04-01

Multiple stellar systems are ubiquitous in the Milky Way but are often unresolved and seen as single objects in spectroscopic, photometric, and astrometric surveys. However, modeling them is essential for developing a full understanding of large surveys such as Gaia and connecting them to stellar and Galactic models. In this paper, we address this problem by jointly fitting the Gaia and Two Micron All Sky Survey photometric and astrometric data using a data-driven Bayesian hierarchical model that includes populations of binary and trinary systems. This allows us to classify observations into singles, binaries, and trinaries, in a robust and efficient manner, without resorting to external models. We are able to identify multiple systems and, in some cases, make strong predictions for the properties of their unresolved stars. We will be able to compare such predictions with Gaia Data Release 4, which will contain astrometric identification and analysis of binary systems.

Could a Collision Between a Ghost Galaxy and the Milky Way be the Origin of the VPOS or DoS?

NASA Astrophysics Data System (ADS)

Bohórquez, O. A.; Casas, A. R.

2018-01-01

At present within the area of astrophysics there are a number of unresolved problems, including the origin of the satellite galaxies of the Milky Way. Most of these galaxies are characterized as dwarf spheroidal galaxies. The large majority of them is distributed in a disk-like structure which is arranged almost perpendicular to the plane of the Galaxy, this structure is known as disk of satellites (DoS) or Vast Polar structure of Satellite galaxies (VPoS). So far there is not a model that fully reproduces the amount and spatial distribution of these galaxies. However there have been several proposed for the solutions, one of which suggests that these originated in the collision of two disk galaxies billions of years ago. Using the Gadget2 software, we have performed N-bodies numerical simulations of the collision between two disk galaxies that could give rise to disk of Milky Way satellites.

Vertebrate Reservoirs of Arboviruses: Myth, Synonym of Amplifier, or Reality?

PubMed Central

Kuno, Goro; Mackenzie, John S.; Plyusnin, Alexander; Gubler, Duane J.

2017-01-01

The rapid succession of the pandemic of arbovirus diseases, such as dengue, West Nile fever, chikungunya, and Zika fever, has intensified research on these and other arbovirus diseases worldwide. Investigating the unique mode of vector-borne transmission requires a clear understanding of the roles of vertebrates. One major obstacle to this understanding is the ambiguity of the arbovirus definition originally established by the World Health Organization. The paucity of pertinent information on arbovirus transmission at the time contributed to the notion that vertebrates played the role of reservoir in the arbovirus transmission cycle. Because this notion is a salient feature of the arbovirus definition, it is important to reexamine its validity. This review addresses controversial issues concerning vertebrate reservoirs and their role in arbovirus persistence in nature, examines the genesis of the problem from a historical perspective, discusses various unresolved issues from multiple points of view, assesses the present status of the notion in light of current knowledge, and provides options for a solution to resolve the issue. PMID:28703771

Vertebrate Reservoirs of Arboviruses: Myth, Synonym of Amplifier, or Reality?

PubMed

Kuno, Goro; Mackenzie, John S; Junglen, Sandra; Hubálek, Zdeněk; Plyusnin, Alexander; Gubler, Duane J

2017-07-13

The rapid succession of the pandemic of arbovirus diseases, such as dengue, West Nile fever, chikungunya, and Zika fever, has intensified research on these and other arbovirus diseases worldwide. Investigating the unique mode of vector-borne transmission requires a clear understanding of the roles of vertebrates. One major obstacle to this understanding is the ambiguity of the arbovirus definition originally established by the World Health Organization. The paucity of pertinent information on arbovirus transmission at the time contributed to the notion that vertebrates played the role of reservoir in the arbovirus transmission cycle. Because this notion is a salient feature of the arbovirus definition, it is important to reexamine its validity. This review addresses controversial issues concerning vertebrate reservoirs and their role in arbovirus persistence in nature, examines the genesis of the problem from a historical perspective, discusses various unresolved issues from multiple points of view, assesses the present status of the notion in light of current knowledge, and provides options for a solution to resolve the issue.

Axions, inflation and the anthropic principle

NASA Astrophysics Data System (ADS)

Mack, Katherine J.

2011-07-01

The QCD axion is the leading solution to the strong-CP problem, a dark matter candidate, and a possible result of string theory compactifications. However, for axions produced before inflation, symmetry-breaking scales of fagtrsim1012 GeV (which are favored in string-theoretic axion models) are ruled out by cosmological constraints unless both the axion misalignment angle θ0 and the inflationary Hubble scale HI are extremely fine-tuned. We show that attempting to accommodate a high-fa axion in inflationary cosmology leads to a fine-tuning problem that is worse than the strong-CP problem the axion was originally invented to solve. We also show that this problem remains unresolved by anthropic selection arguments commonly applied to the high-fa axion scenario.

LES of Sooting Flames

DTIC Science & Technology

2006-12-01

27], [28] on soot nucleation, and [29] on the soot formation in diesel engines . [27] discussed the unresolved problems in SOx, NOx , and soot...used LEM approach to study aerosol dynamics in engine exhaust plumes. Recently, [41] used detailed NOx mechanism combined with MOM to predict the...combustion engines . For instance, the laminar flamelet approach used by [43, 44, 45], allows the usage of a detailed chemical mechanism but is not

Semi-Annual Report to Congress: October 1, 1980-March 31, 1981. (Submitted Pursuant to Public Law 95-452).

ERIC Educational Resources Information Center

Office of Inspector General (ED), Washington, DC.

In four sections, this document reports on the activities of the Office of Inspector General (OIG), which provides audit, investigation, fraud detection and prevention, and certain security services to the U.S. Department of Education. Section 1 presents data on OIG audit activities, money recovered or saved, and the problem of unresolved audits,…

Global Governance 2025: At a Critical Juncture

DTIC Science & Technology

2010-09-01

them. Formal institutions remain largely unreformed and Western states probably must shoulder a disproportionate share of “global governance” as...might be in a better position but may still be fiscally constrained if its budgetary shortfalls and long-term debt problems remain unresolved...that undermine both the environment and investment. Reliance on domestic reserves of fossil fuels or long- term access to foreign fields makes

Symmetry breaking and uniqueness for the incompressible Navier-Stokes equations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dascaliuc, Radu; Thomann, Enrique; Waymire, Edward C., E-mail: waymire@math.oregonstate.edu

2015-07-15

The present article establishes connections between the structure of the deterministic Navier-Stokes equations and the structure of (similarity) equations that govern self-similar solutions as expected values of certain naturally associated stochastic cascades. A principle result is that explosion criteria for the stochastic cascades involved in the probabilistic representations of solutions to the respective equations coincide. While the uniqueness problem itself remains unresolved, these connections provide interesting problems and possible methods for investigating symmetry breaking and the uniqueness problem for Navier-Stokes equations. In particular, new branching Markov chains, including a dilogarithmic branching random walk on the multiplicative group (0, ∞), naturallymore » arise as a result of this investigation.« less

Symmetry breaking and uniqueness for the incompressible Navier-Stokes equations.

PubMed

Dascaliuc, Radu; Michalowski, Nicholas; Thomann, Enrique; Waymire, Edward C

2015-07-01

The present article establishes connections between the structure of the deterministic Navier-Stokes equations and the structure of (similarity) equations that govern self-similar solutions as expected values of certain naturally associated stochastic cascades. A principle result is that explosion criteria for the stochastic cascades involved in the probabilistic representations of solutions to the respective equations coincide. While the uniqueness problem itself remains unresolved, these connections provide interesting problems and possible methods for investigating symmetry breaking and the uniqueness problem for Navier-Stokes equations. In particular, new branching Markov chains, including a dilogarithmic branching random walk on the multiplicative group (0, ∞), naturally arise as a result of this investigation.

Equity for Cities in School Finance Reform: A Case for an "Equal Educational Offering" Standard in Public Education.

ERIC Educational Resources Information Center

Silard, John; And Others

In this study, focus is upon the question of the standard for educational expenditure rather than on the alternative taxing methods for securing school district funding equalization. Chapter I begins by examining the major issues vital to urban education which the "Serrano" principle leaves unresolved. Then in Chapter II, particular elements of…

Unresolved Issues and New Challenges in Teaching English to Young Learners: The Case of South Korea

ERIC Educational Resources Information Center

Garton, Sue

2014-01-01

The introduction of languages, especially English, into the primary curriculum around the world has been one of the major language-in-education policy developments in recent years. In countries where English has been compulsory for a number of years, the question arises as to what extent the numerous and well-documented challenges faced by the…

Thyrotropin receptor mutations and thyroid hyperfunctioning adenomas ten years after their first discovery: unresolved questions.

PubMed

Arturi, F; Scarpelli, D; Coco, A; Sacco, R; Bruno, R; Filetti, S; Russo, D

2003-04-01

Ten years after the first description of activating mutations in the thyroid stimulating hormone receptor (TSHR) gene in sporadic autonomous hyperfunctioning thyroid adenomas, there is general agreement in assigning a major pathogenic role of this genetic abnormality, acting via the constitutive activation of the cAMP pathway, in both the growth and functional characteristic of these tumours. From the beginning, however, the pathophysiological and clinical relevance of somatic TSHR mutations has been debated and some arguments still exist against a fully causative role of these mutations and the practical value of detecting these mutations for the diagnosis, treatment and prognosis of thyroid hot nodules. Some major issues will be examined herein, including (a) the frequency of TSHR alterations in various reports showing that the genetic abnormality underlying the pathogenesis of a substantial subset of thyroid tumours has yet to be identified; (b) the limitations of the present experimental models, which suggest greater caution in the interpretation of in vitro results; (c) the still unresolved question of absence of genotype-phenotype correlation. Clarification of these issues may hopefully provide new and useful tools for improving the clinical management of this disease.

Molecular engineering of colloidal liquid crystals using DNA origami

NASA Astrophysics Data System (ADS)

Siavashpouri, Mahsa; Wachauf, Christian; Zakhary, Mark; Praetorius, Florian; Dietz, Hendrik; Dogic, Zvonimir

Understanding the microscopic origin of cholesteric phase remains a foundational, yet unresolved problem in the field of liquid crystals. Lack of experimental model system that allows for the systematic control of the microscopic chiral structure makes it difficult to investigate this problem for several years. Here, using DNA origami technology, we systematically vary the chirality of the colloidal particles with molecular precision and establish a quantitative relationship between the microscopic structure of particles and the macroscopic cholesteric pitch. Our study presents a new methodology for predicting bulk behavior of diverse phases based on the microscopic architectures of the constituent molecules.

Patchwork plagiarism – a jigsaw of stolen puzzle pieces

PubMed Central

Smolčić, Vesna Šupak; Bilić-Zulle, Lidija

2013-01-01

Plagiarism remains at the top in terms of interest to the scientific community. In its many vicious forms, patchwork plagiarism is characterized by numerous unresolved issues and often passes “below the radar” of editors and reviewers. The problem of detecting the complexity of misconduct has been partially resolved by plagiarism detection software. However, interpretation of relevant reports is not always obvious or easy. This article deals with plagiarism in general and patchwork plagiarism in particular, as well as related problems that editors must deal with to maintain the integrity of scientific journals. PMID:23457762

Exploring the psychological and somatic impact of identity theft.

PubMed

Sharp, Tracy; Shreve-Neiger, Andrea; Fremouw, William; Kane, John; Hutton, Shawn

2004-01-01

Identity theft is a new and growing form of white-collar crime. This exploratory study examined the psychological and somatic impact of identity theft and coping methods utilized by victims. Thirty-seven victims of identity theft participated in regional victim focus groups. Participants completed a victim impact questionnaire designed by the authors and the Brief Symptom Inventory-18 (BSI-18). The majority of participants expressed an increase in maladaptive psychological and somatic symptoms post victimization. Results on the BSI indicated that identity theft victims with unresolved cases, in contrast to those with resolved cases, were more likely to have clinically elevated scores when compared with a normative sample. Relatively similar coping mechanisms were utilized across victims. The results from this study suggest that victims of identity theft do have increased psychological and physical distress, and for those whose cases remain unresolved, distress is maintained over time.

Parents' Voice in Managing the Pain of Children with Cancer during Palliative Care.

PubMed

Mariyana, Rina; Allenidekania, Allenidekania; Nurhaeni, Nani

2018-01-01

Pain experienced by children can adversely affect their growth and development. Pain is a major health problem for cancer patients and remains an unresolved problem. To know how the experiences of mothers managing their children's pain during palliative care following cancer diagnosis. Pain experienced by children can adversely affect their growth and development. Using qualitative methods within a descriptive phenomenological approach, in-depth interviews were conducted with parents (mostly mothers) of eight children diagnosed with cancer. The data were collected using the snowball sampling method. Participants experienced in managing the pain of children with cancer. Analysis of the results identified 8 themes: the dimensions of pain experienced by children undergoing palliative care; mothers' physical and psychological responses; mothers' emotional responses; barriers encountered by mothers when taking care of their child at home; mothers' interventions to reduce their child's pain; mothers' efforts to distract their child from pain; giving encouragement when the child is in pain; and mothers' efforts and prayers to make their child comfort. It can be concluded that the child's pain is the main cause of mothers' stress and pressure and also affects the daily lives of mothers and children. Along with the most effective intervention, nurses need to provide mothers and children with adequate information about cancer pain.

The generation of plate tectonics from mantle convection

NASA Astrophysics Data System (ADS)

Bercovici, David

2003-01-01

In the last decade, significant progress has been made toward understanding how plate tectonics is generated from mantle dynamics. A primary goal of plate-generation studies has been the development of models that allow the top cold thermal boundary layer of mantle convection, i.e. the lithosphere, to develop broad and strong plate-like segments separated by narrow, weak and rapidly deforming boundaries; ideally, such models also permit significant strike-slip (toroidal) motion, passive ridges (i.e. pulled rather than pried apart), and self-consistent initiation of subduction. A major outcome of work so far is that nearly all aspects of plate generation require lithospheric rheologies and shear-localizing feedback mechanisms that are considerably more exotic than rheologies typically used in simple fluid-dynamical models of mantle flow. The search for plate-generating behavior has taken us through investigations of the effects of shear weakening ('stick-slip') and viscoplastic rheologies, of melting at ridges and low-viscosity asthenospheres, and of grain-size dependent rheologies and damage mechanics. Many such mechanisms, either by themselves or in combination, have led to self-consistent fluid-mechanical models of mantle flow that are remarkably plate-like, which is in itself a major accomplishment. However, many other important problems remain unsolved, such as subduction intiation and asymmetry, temporal evolution of plate geometry, rapid changes in plate motion, and the Archaean initiation of the plate-tectonic mode of convection. This paper presents a brief review of progress made in the plate-generation problem over the last decade, and discusses unresolved issues and future directions of research in this important area.

An exploration of family dynamics and attachment strategies in a family with ADHD/conduct problems.

PubMed

Dallos, Rudi; Smart, Cordet

2011-10-01

This article reports the preliminary findings of a study of attachment patterns and relationship themes using the TAAI (Transition to Adulthood Attachment Interview), AAI (Adult Attachment Interview) and family interviews (based on the first of 15 families). Research data is presented on a young man aged 16 with a diagnosis of ADHD and his family. Individual interviews, attachment interviews, and family interviews were conducted in order to explore the link between family dynamics, ADHD and attachment strategies. In contrast to findings from existing research indicating pre-occupied patterns for young people diagnosed with ADHD, the young man displayed a complex 'disoriented' attachment pattern which primarily featured a dismissive strategy. However, this was combined with pre-occupied patterns triggered by intrusions from unresolved traumas and memories of his parents' continuing unresolved conflicts. His sense of confusion and lack of a coherent strategy appeared to be closely related to his position of being triangulated into his parents' conflicts. Trans-generational processes were also influential, in that the parents' corrective intentions at more positive parenting were impeded by their own lack of experience of positive attachments in their own childhoods. The study emphasizes the need to consider the relationship between attachment patterns and problems within wider systemic process in the family, in particular triangulation and corrective scripts.

The amphibians and reptiles of Mindanao Island, southern Philippines, II: the herpetofauna of northeast Mindanao and adjacent islands

PubMed Central

Sanguila, Marites B.; Cobb, Kerry A.; Siler, Cameron D.; Diesmos, Arvin C.; Alcala, Angel C.; Brown, Rafe M.

2016-01-01

Abstract We summarize all available amphibian and reptile species distribution data from the northeast Mindanao faunal region, including small islands associated with this subcenter of endemic vertebrate biodiversity. Together with all publicly available historical information from biodiversity repositories, we present new data from several major herpetological surveys, including recently conducted inventories on four major mountains of northeast Mindanao, and adjacent islands of Camiguin Sur, Dinagat, and Siargao. We present species accounts for all taxa, comment on unresolved taxonomic problems, and provide revisions to outdated IUCN conservation status assessments in cases where our new data significantly alter earlier classification status summaries. Together, our comprehensive analysis of this fauna suggests that the greater Mindanao faunal region possesses distinct subcenters of amphibian and reptile species diversity, and that until this area is revisited and its fauna and actually studied, with on-the-ground field work including targeted surveys of species distributions coupled to the study their natural history, our understanding of the diversity and conservation status of southern Philippine herpetological fauna will remain incomplete. Nevertheless, the northeast Mindanao geographical area (Caraga Region) appears to have the highest herpetological species diversity (at least 126 species) of any comparably-sized Philippine faunal subregion. PMID:27833422

Rethinking policy perspectives on childhood stunting: time to formulate a structural and multifactorial strategy.

PubMed

Subramanian, S V; Mejía-Guevara, Iván; Krishna, Aditi

2016-05-01

Stunting and chronic undernutrition among children in South Asia remain a major unresolved global health issue. There are compelling intrinsic and moral reasons to ensure that children attain their optimal growth potential facilitated via promotion of healthy living conditions. Investments in efforts to ensure that children's growth is not faltered also have substantial instrumental benefits in terms of cognitive and economic development. Using the case of India, we critique three prevailing approaches to reducing undernutrition among children: an over-reliance on macroeconomic growth as a potent policy instrument, a disproportionate focus on interpreting undernutrition as a demand-side problem and an over-reliance on unintegrated single-factorial (one at a time) approaches to policy and research. Using existing evidence, we develop a case for support-led policy approach with a focus on integrated and structural factors to addressing the problem of undernutrition among children in India. Key messages Eliminating child undernutrition is important from an intrinsic perspective and offers considerable instrumental benefits to individual and society. Evidence suggests that an exclusive reliance on a growth-mediated strategy to eliminate stunting needs to be reconsidered, suggesting the need for a substantial support-led strategy. Interpreting and addressing undernutrition as a demand-side problem with proximal single-factorial interventions is futile. There is an urgent need to develop interventions that address the broader structural and upstream causes of child undernutrition. © 2016 The Authors. Maternal & Child Nutrition published by John Wiley & Sons Ltd.

On Retirement of Physicians

PubMed Central

Levy, Roy

1986-01-01

This article takes a look at retirement in general, and the implications for physicians in particular. The recent application of the principles in the Canadian Charter of Rights has raised some unresolved issues for those doctors with contractual employment. They may no longer have mandatory retirement at age 65. Problems can and do arise when self-employed physicians defer retirement from active practice indefinitely. The evaluation of older physicians' competence is explored, and some suggestions offered. PMID:21267269

Problems of systems dataware using optoelectronic measuring means of linear displacement

NASA Astrophysics Data System (ADS)

Bazykin, S. N.; Bazykina, N. A.; Samohina, K. S.

2017-10-01

Problems of the dataware of the systems with the use of optoelectronic means of the linear displacement are considered in the article. The classification of the known physical effects, realized by the means of information-measuring systems, is given. The organized analysis of information flows in technical systems from the standpoint of determination of inaccuracies of measurement and management was conducted. In spite of achieved successes in automation of machine-building and instruments-building equipment in the field of dataware of the technical systems, there are unresolved problems, concerning the qualitative aspect of the production process. It was shown that the given problem can be solved using optoelectronic lazer information-measuring systems. Such information-measuring systems are capable of not only executing the measuring functions, but also solving the problems of management and control during processing, thereby guaranteeing the quality of final products.

Methodological considerations in service use assessment for children and youth with mental health conditions; issues for economic evaluation.

PubMed

Woolderink, M; Lynch, F L; van Asselt, A D I; Beecham, J; Evers, S M A A; Paulus, A T G; van Schayck, C P

2015-05-01

Economic evaluations are increasingly used in decision-making. Accurate measurement of service use is critical to economic evaluation. This qualitative study, based on expert interviews, aims to identify best approaches to service use measurement for child mental health conditions, and to identify problems in current methods. Results suggest considerable agreement on strengths (e.g., availability of accurate instruments to measure service use) and weaknesses, (e.g., lack of unit prices for services outside the health sector) or alternative approaches to service use measurement. Experts also identified some unresolved problems, for example the lack of uniform definitions for some mental health services.

Axions, inflation and the anthropic principle

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mack, Katherine J., E-mail: mack@ast.cam.ac.uk

2011-07-01

The QCD axion is the leading solution to the strong-CP problem, a dark matter candidate, and a possible result of string theory compactifications. However, for axions produced before inflation, symmetry-breaking scales of f{sub a}∼>10{sup 12} GeV (which are favored in string-theoretic axion models) are ruled out by cosmological constraints unless both the axion misalignment angle θ{sub 0} and the inflationary Hubble scale H{sub I} are extremely fine-tuned. We show that attempting to accommodate a high-f{sub a} axion in inflationary cosmology leads to a fine-tuning problem that is worse than the strong-CP problem the axion was originally invented to solve. Wemore » also show that this problem remains unresolved by anthropic selection arguments commonly applied to the high-f{sub a} axion scenario.« less

An analysis of the technical status of high level radioactive waste and spent fuel management systems

NASA Technical Reports Server (NTRS)

English, T.; Miller, C.; Bullard, E.; Campbell, R.; Chockie, A.; Divita, E.; Douthitt, C.; Edelson, E.; Lees, L.

1977-01-01

The technical status of the old U.S. mailine program for high level radioactive nuclear waste management, and the newly-developing program for disposal of unreprocessed spent fuel was assessed. The method of long term containment for both of these waste forms is considered to be deep geologic isolation in bedded salt. Each major component of both waste management systems is analyzed in terms of its scientific feasibility, technical achievability and engineering achievability. The resulting matrix leads to a systematic identification of major unresolved technical or scientific questions and/or gaps in these programs.

Supermassive black-hole growth over cosmic time: active galaxy demography, physics, and ecology from Chandra surveys.

PubMed

Brandt, W N; Alexander, D M

2010-04-20

Extragalactic X-ray surveys over the past decade have dramatically improved understanding of the majority populations of active galactic nuclei (AGNs) over most of the history of the universe. Here we briefly highlight some of the exciting discoveries about AGN demography, physics, and ecology, with a focus on results from Chandra. We also discuss some key unresolved questions and future prospects.

Supermassive black-hole growth over cosmic time: Active galaxy demography, physics, and ecology from Chandra surveys

PubMed Central

Brandt, W. N.; Alexander, D. M.

2010-01-01

Extragalactic X-ray surveys over the past decade have dramatically improved understanding of the majority populations of active galactic nuclei (AGNs) over most of the history of the universe. Here we briefly highlight some of the exciting discoveries about AGN demography, physics, and ecology, with a focus on results from Chandra. We also discuss some key unresolved questions and future prospects. PMID:20404160

They still grieve-a nationwide follow-up of young adults 2-9 years after losing a sibling to cancer.

PubMed

Sveen, Josefin; Eilegård, Alexandra; Steineck, Gunnar; Kreicbergs, Ulrika

2014-06-01

The aims of this study were to assess the prevalence of unresolved grief in bereaved young adult siblings and examine possible contributing factors. The study was a Swedish population-based study of young adults who had lost a brother or sister to cancer, 2-9 years earlier. Of 240 eligible siblings, 174 (73%) completed a study-specific questionnaire. This study focused on whether the respondents had worked through their grief over the sibling's death and to what extent. A majority (54%) of siblings stated that they had worked through their grief either 'not at all' or 'to some extent' at the time of investigation. In multiple regression analyses with unresolved grief as the dependent variable, 21% of the variance was explained by lack of social support and shorter time since loss. The majority of bereaved young adults had not worked through their grief over the sibling's death. A small group of siblings reported that they had not worked through their grief at all, which may be an indicator of prolonged grief. Lack of social support and more recent loss were associated with not having worked through the grief over the sibling's death. Copyright © 2013 John Wiley & Sons, Ltd.

A Decade of e-Cigarettes: Limited Research & Unresolved Safety Concerns

PubMed Central

Kaisar, Mohammad Abul; Prasad, Shikha; Liles, Tylor; Cucullo, Luca

2016-01-01

It is well known that tobacco consumption is a leading cause of preventable deaths worldwide and has been linked to major diseases ranging from cancer to chronic obstructive pulmonary disease, atherosclerosis, stroke and a host of neurological/neurodegenerative disorders. In the past decade a number of alternative vaping products have hit the market, rapidly gaining consumers especially among the younger population. Electronic nicotine delivery systems or e-cigarettes have become the sought-after product due to the belief that they are much safer than traditional cigarettes. However, inadequate research and lack of regulatory guidelines for both the manufacturing process and the content of the vaping solution of the e-cigarette has become a major concern. Highly debated and unresolved questions such as whether e-cigarettes may help smokers quit and whether e-cigarettes will promote the use of nicotine among non-smokers add to the confusion of the safety of e-cigarettes. In this review article, we summarize the current understanding (and lack thereof) of the potential health impacts of e-cigarettes. We will also highlight the most recent studies (in vivo/in vitro) which seem to conflict with the broad safety claims put forward by the manufacturers. Finally, we provide potential solutions to overcome the research gap of the short and long-term health impact of e-cigarettes. PMID:27477296

Glucagon-like peptide-1 analogs against antipsychotic-induced weight gain: potential physiological benefits

PubMed Central

2012-01-01

Background Antipsychotic-induced weight gain constitutes a major unresolved clinical problem which may ultimately be associated with reducing life expectancy by 25 years. Overweight is associated with brain deterioration, cognitive decline and poor quality of life, factors which are already compromised in normal weight patients with schizophrenia. Here we outline the current strategies against antipsychotic-induced weight gain, and we describe peripheral and cerebral effects of the gut hormone glucagon-like peptide-1 (GLP-1). Moreover, we account for similarities in brain changes between schizophrenia and overweight patients. Discussion Current interventions against antipsychotic-induced weight gain do not facilitate a substantial and lasting weight loss. GLP-1 analogs used in the treatment of type 2 diabetes are associated with significant and sustained weight loss in overweight patients. Potential effects of treating schizophrenia patients with antipsychotic-induced weight gain with GLP-1 analogs are discussed. Conclusions We propose that adjunctive treatment with GLP-1 analogs may constitute a new avenue to treat and prevent metabolic and cerebral deficiencies in schizophrenia patients with antipsychotic-induced weight gain. Clinical research to support this idea is highly warranted. PMID:22891821

Combined theoretical and experimental analysis of processes determining cathode performance in solid oxide fuel cells.

PubMed

Kuklja, M M; Kotomin, E A; Merkle, R; Mastrikov, Yu A; Maier, J

2013-04-21

Solid oxide fuel cells (SOFC) are under intensive investigation since the 1980's as these devices open the way for ecologically clean direct conversion of the chemical energy into electricity, avoiding the efficiency limitation by Carnot's cycle for thermochemical conversion. However, the practical development of SOFC faces a number of unresolved fundamental problems, in particular concerning the kinetics of the electrode reactions, especially oxygen reduction reaction. We review recent experimental and theoretical achievements in the current understanding of the cathode performance by exploring and comparing mostly three materials: (La,Sr)MnO3 (LSM), (La,Sr)(Co,Fe)O3 (LSCF) and (Ba,Sr)(Co,Fe)O3 (BSCF). Special attention is paid to a critical evaluation of advantages and disadvantages of BSCF, which shows the best cathode kinetics known so far for oxides. We demonstrate that it is the combined experimental and theoretical analysis of all major elementary steps of the oxygen reduction reaction which allows us to predict the rate determining steps for a given material under specific operational conditions and thus control and improve SOFC performance.

Ultralow threading dislocation density in GaN epilayer on near-strain-free GaN compliant buffer layer and its applications in hetero-epitaxial LEDs.

PubMed

Shih, Huan-Yu; Shiojiri, Makoto; Chen, Ching-Hsiang; Yu, Sheng-Fu; Ko, Chung-Ting; Yang, Jer-Ren; Lin, Ray-Ming; Chen, Miin-Jang

2015-09-02

High threading dislocation (TD) density in GaN-based devices is a long unresolved problem because of the large lattice mismatch between GaN and the substrate, which causes a major obstacle for the further improvement of next-generation high-efficiency solid-state lighting and high-power electronics. Here, we report InGaN/GaN LEDs with ultralow TD density and improved efficiency on a sapphire substrate, on which a near strain-free GaN compliant buffer layer was grown by remote plasma atomic layer deposition. This "compliant" buffer layer is capable of relaxing strain due to the absorption of misfit dislocations in a region within ~10 nm from the interface, leading to a high-quality overlying GaN epilayer with an unusual TD density as low as 2.2 × 10(5) cm(-2). In addition, this GaN compliant buffer layer exhibits excellent uniformity up to a 6" wafer, revealing a promising means to realize large-area GaN hetero-epitaxy for efficient LEDs and high-power transistors.

Coaching Family Caregivers to Become Better Problem Solvers When Caring for Persons with Advanced Cancer.

PubMed

Dionne-Odom, J Nicholas; Lyons, Kathleen D; Akyar, Imatullah; Bakitas, Marie A

2016-01-01

Family caregivers of persons with advanced cancer often take on responsibilities that present daunting and complex problems. Serious problems that go unresolved may be burdensome and result in negative outcomes for caregivers' psychological and physical health and affect the quality of care delivered to the care recipients with cancer, especially at the end of life. Formal problem-solving training approaches have been developed over the past several decades to assist individuals with managing problems faced in daily life. Several of these problem-solving principles and techniques were incorporated into ENABLE (Educate, Nurture, Advise, Before Life End), an "early" palliative care telehealth intervention for individuals diagnosed with advanced cancer and their family caregivers. A hypothetical case resembling the situations of actual caregiver participants in ENABLE that exemplifies the complex problems that caregivers face is presented, followed by presentation of an overview of ENABLE's problem-solving key principles, techniques, and steps in problem-solving support. Though more research is needed to formally test the use of problem-solving support in social work practice, social workers can easily incorporate these techniques into everyday practice.

From Unresolved Anger to Sadness: Identifying Physiological Correlates

ERIC Educational Resources Information Center

Rochman, Daniel; Diamond, Gary M.

2008-01-01

This study was designed to identify physiological correlates of unresolved anger and sadness, and the shift between these emotions, in a context similar to that of emotion-focused, experiential psychotherapy. Twenty-seven university students reporting unresolved anger toward an attachment figure were induced to experience and express unresolved…

Analysis of a Compressible Fluid Soft Recoil (CFSR) Concept Applied to a 155 MM Howitzer

DTIC Science & Technology

1979-03-01

Nitrile or Buna-N ( NBR ) rubber with ’ backup rings of nylotron. HITRILE NVLOTRON Piston seals An unresolved problem is that the coefficient of...fluid at atmospheric pressure Poisson’s ratio for Nitrile rubber dynamic coefficient of friction for rubber mass of recoiling parts weight of...Greene, tweed 5 Co. Palmetto catalog.) 43 [i^ - 0.50 = coefficient of friction (An approximate figure for rubber supplied by RIA Rubber

MCNP/X TRANSPORT IN THE TABULAR REGIME

DOE Office of Scientific and Technical Information (OSTI.GOV)

HUGHES, H. GRADY

2007-01-08

The authors review the transport capabilities of the MCNP and MCNPX Monte Carlo codes in the energy regimes in which tabular transport data are available. Giving special attention to neutron tables, they emphasize the measures taken to improve the treatment of a variety of difficult aspects of the transport problem, including unresolved resonances, thermal issues, and the availability of suitable cross sections sets. They also briefly touch on the current situation in regard to photon, electron, and proton transport tables.

The P-38 Lightning Aircraft: Lessons Learned for Future Weapon Systems Development

DTIC Science & Technology

2010-04-01

PMBOK TEL \\ u.s. WER List of ~cronyms iv Brake Horse Power Design-Build Team District of Columbia Department of Defense Department of...record. Despite unresolved issues like the flap and brake system problems and limited test hours, on 11 February 1939, Lieutenant Kelsey flew the XP-38...engine, giving the P-3 8 engines a 1425 brake horse power (BHP)22 rating. However, limitations of the integral wing leading edge intercoolers23 could

Pancreatic cancer in 1988. Possibilities and probabilities.

PubMed Central

Warshaw, A L; Swanson, R S

1988-01-01

Pancreatic adenocarcinoma is increasing in frequency, generally grows without symptoms until late in its natural history, and presents many discouraging unresolved problems in management. This review analyzes the status of current modalities of diagnosis, staging, and treatment. The limitations of those methods are defined, and possible improvements and new directions are suggested. A strategy for a rational and humane approach to pancreatic cancer is developed with the goal of maximizing quality as well as quantity of life. PMID:2461172

Osteoporosis: should there be a screening programme in Hong Kong?

PubMed

Hui, Y

2002-08-01

Osteoporosis is rapidly becoming a major health problem in Hong Kong with the ever-increasing population of elderly people. Its importance lies in the predisposition to fragility fractures of patients with the disease. These fractures incur morbidity and mortality to the elderly. Measures are needed to reduce the prevalence of osteoporosis and the incidence of osteoporotic fractures. A screening programme is potentially the way forward in achieving such a goal. The need for, and the feasibility of, a screening programme for osteoporosis in Hong Kong were evaluated. A comprehensive examination of the relevant issues was carried out within the framework of the World Health Organization criteria on screening of diseases. Major studies from abroad and Hong Kong were discussed and the strength of evidence was assessed. Osteoporosis satisfies some of the World Health Organization criteria for screening of diseases: it is a significant health problem, the natural history is fairly well understood, and early detection is possible. Nevertheless, there remain unresolved issues related to the screening tests, the treatments currently available, and the selection criteria for treatment. Several therapeutic options have been tested in trials. However, more work is needed to determine whether, in addition to increasing bone mass, they reduce the incidence of fracture. Moreover, the duration of therapy needed to achieve long-term benefit has yet to be established. More studies are also needed to evaluate the cost-effectiveness of such a programme. There undoubtedly needs to be a means of identifying individuals who have osteoporosis and are susceptible to fragility fractures. However, based on the currently available evidence, large-scale screening is not a valid option. Before instituting such a programme in Hong Kong, more studies are needed to determine the most appropriate and cost-effective way forward.

Framing the Mind-Body Problem in Contemporary Neuroscientific and Sunni Islamic Theological Discourse.

PubMed

Qazi, Faisal; Fette, Don; Jafri, Syed S; I Padela, Aasim

2018-07-01

Famously posed by seventeenth-century French philosopher René Descartes, the mind-body problem remains unresolved in western philosophy and science, with both disciplines unable to move convincingly beyond the dualistic model. The persistence of dualism calls for a reframing of the problem through interdisciplinary modes of inquiry that include non-western points of view. One such perspective is Islamic theology of the soul, which, while approaching the problem from a distinct point of view, also adopts a position commensurate with (substance) dualism. Using this point of convergence as a conceptual starting point, we argue that bringing into dialogue contemporary neuroscientific, philosophy of mind, and Sunni Islamic theological discourses may provide a fruitful way of reframing the age-old mind-body problem. This paper provides an overview of how these three discourses have approached the issue of the mind-body (-soul) problem. Juxtaposing these three discourses, we hope, may ignite further scholarly dialogue and investigation.

Change in attachment states of mind of women with binge-eating disorder.

PubMed

Maxwell, Hilary; Tasca, Giorgio A; Grenon, Renee; Ritchie, Kerri; Bissada, Hany; Balfour, Louise

2017-11-01

Insecure and unresolved/disorganized attachment states of mind may impact affect regulation and interpersonal functioning that contribute to binge eating in women with binge-eating disorder (BED). Group psychological treatment may facilitate changes from insecure to secure and from unresolved-disorganized to non-unresolved/disorganized attachment states of mind. This study used attachment theory to understand better the psychopathology of BED and co-morbid overweight status and to understand better the treatment response of patients with BED who receive group psychotherapy. Women with BED attended group psychodynamic interpersonal psychotherapy and completed the Adult Attachment Interview pretreatment and 6 months posttreatment. Matched samples of overweight women without BED and normal-weight women without BED completed the Adult Attachment Interview at 1 time point. Women with BED had significantly higher rates of preoccupied and unresolved/disorganized attachment states of mind compared to normal-weight women without BED and had similar rates of insecure and unresolved/disorganized attachment states of mind compared to overweight women without BED. Of the women with BED who had an insecure and/or unresolved/disorganized attachment states of mind at pretreatment, about 60% demonstrated clinically relevant changes to secure and to non-unresolved/disorganized states of mind at 6 months post group psychodynamic interpersonal psychotherapy. Results indicated that some women with BED may benefit from interventions that help them regulate hyperactivated affect and create coherent narratives. Both women with BED and overweight women without BED may benefit from treatments that help them develop more adaptive affect regulation strategies related to unresolved/disorganized attachment states of mind. Copyright © 2017 John Wiley & Sons, Ltd.

77 FR 42788 - Self-Regulatory Organizations; New York Stock Exchange LLC; Notice of Filing and Immediate...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-20

... Unresolved Account Balances in the Exchange's Online Comparison System July 16, 2012. Pursuant to Section 19... assigning the contra party to unresolved account balances in the Exchange's Online Comparison System. The... maker (``DMM'') unit as the contra party for any unresolved omnibus account balances in the Exchange's...

Immunogenicity and immune tolerance coagulation Factors VIII and IX.

PubMed

Rup, B

2003-01-01

Some of the major issues related to the development and control of antibodies that occur during treatment of haemophilia with replacement factors (Factor VIII and Factor IX) are reviewed. Information on analytical issues, immunogenicity, and immune tolerance may be applicable to the study of other therapeutic proteins. Conversely, new information obtained from evaluation of other therapeutic protein products may address issues that remain unresolved for Factor VIII and FIX replacement therapy.

Perception of the pitch of unresolved harmonics by 3- and 7-month-old human infants.

PubMed

Lau, Bonnie K; Werner, Lynne A

2014-08-01

Three-month-olds discriminate resolved harmonic complexes on the basis of missing fundamental (MF) pitch. In view of reported difficulty in discriminating unresolved complexes at 7 months and striking changes in the organization of the auditory system during early infancy, infants' ability to discriminate unresolved complexes is of some interest. This study investigated the ability of 3-month-olds, 7-month-olds, and adults to discriminate the pitch of unresolved harmonic complexes using an observer-based method. Stimuli were MF complexes bandpass filtered with a -12 dB/octave slope, combined in random phase, presented at 70 dB sound pressure level (SPL) for 650 ms with a 50 ms rise/fall with a pink noise at 65 dB SPL. The conditions were (1) "LOW" unresolved harmonics (2500-4500 Hz) based on MFs of 160 and 200 Hz and (2) "HIGH" unresolved harmonics (4000-6000 Hz) based on MFs of 190 and 200 Hz. To demonstrate MF discrimination, participants had to ignore spectral changes in complexes with the same fundamental and respond only when the fundamental changed. Nearly all infants tested categorized complexes by MF pitch suggesting discrimination of pitch extracted from unresolved harmonics by 3 months. Adults also categorized the complexes by MF pitch, although musically trained adults were more successful than musically untrained adults.

Hydrogen as an energy medium

NASA Technical Reports Server (NTRS)

Cox, K. E.

1976-01-01

Coal, though abundant in certain geographical locations of the USA poses environmental problems associated with its mining and combustion. Also, nuclear fission energy appears to have problems regarding safety and radioactive waste disposal that are as yet unresolved. The paper discusses hydrogen use and market projection along with energy sources for hydrogen production. Particular attention is given to hydrogen production technology as related to electrolysis and thermochemical water decomposition. Economics of hydrogen will ultimately be determined by the price and availability of future energy carriers such as electricity and synthetic natural gas. Thermochemical methods of hydrogen production appear to offer promise largely in the efficiency of energy conversion and in capital costs over electrolytic methods.

Dispersed storage and generation case studies

NASA Technical Reports Server (NTRS)

Bahrami, K.; Stallkamp, J. A.; Walton, A.

1980-01-01

Three installations utilizing separate dispersed storage and generation (DSG) technologies were investigated. Each of the systems is described in costs and control. Selected institutional and environmental issues are discussed, including life cycle costs. No unresolved technical, environmental, or institutional problems were encountered in the installations. The wind and solar photovoltaic DSG were installed for test purposes, and appear to be presently uneconomical. However, a number of factors are decreasing the cost of DSG relative to conventional alternatives, and an increased DSG penetration level may be expected in the future.

Railroads and shippers clash over coal dust

DOE Office of Scientific and Technical Information (OSTI.GOV)

Buchsbaum, L.

2007-11-15

In an effort to reduce coal spillage from railcars, mines in the Powder River Basin (PRB) now load coal with a loaf profile but, reportedly, beginning in 2008, Burlington Northern Santa Fe (BNSF) will announce guidelines requiring all PRB coal loads to be sprayed with a chemical surfactant. If this does not fix the problem, greater measures will be taken. At the time of going to press, the details of how this would be implemented and regulated were unresolved. 1 photo.

A Comparison of Current Guidelines of Five International Societies on Clostridium difficile Infection Management.

PubMed

Fehér, Csaba; Mensa, Josep

2016-09-01

Clostridium difficile infection (CDI) is increasingly recognized as an emerging healthcare problem of elevated importance. Prevention and treatment strategies are constantly evolving along with the apperance of new scientific evidence and novel treatment methods, which is well-reflected in the differences among consecutive international guidelines. In this article, we summarize and compare current guidelines of five international medical societies on CDI management, and discuss some of the controversial and currently unresolved aspects which should be addressed by future research.

Impulse Noise and Neurosensory Hearing Loss—Relationship to Small Arms Fire

PubMed Central

Keim, Robert J.

1970-01-01

The problems of noise are not limited to the simple annoyance of an individual. Noise can produce a permanent hearing handicap. Many everyday activities and hobbies are associated with hazardous exposure to noise. The hunter and the sport shooter are potential subjects of severe and unresolvable hearing loss. Noise-induced hearing loss develops insidiously. The means of prevention are far more simple than is correction of the loss. Wearing ear protectors, plugs or earmuffs, is advisable during exposure to hazardous noise. PMID:5460217

Conversion of Low Quality Waste Heat to Electric Power with Small-Scale Organic Rankine Cycle (ORC) Engine/Generator Technology

DTIC Science & Technology

2016-06-01

Allan Robichaux, DPW PWD GTMO and the management and staff of the GTMO on site contractor , Centerra. Page Intentionally Left Blank ii Table of...operations and maintenance contractor to ensure that data transfers are completed as required. Figure 4 shows the location of the ORC installation on MUSE...this issue with telephone support from CRM’s controls contractor (Winn-Marion, W-M); however, the problem remained unresolved as of Sept. 1 when

Components of the Extragalactic Gamma-Ray Background

NASA Technical Reports Server (NTRS)

Stecker, Floyd W.; Venters, Tonia M.

2011-01-01

We present new theoretical estimates of the relative contributions of unresolved blazars and star-forming galaxies to the extragalactic gamma-ray background (EGB) and discuss constraints on the contributions from alternative mechanisms such as dark matter annihilation and truly diffuse gamma-ray production. We find that the Fermi source count data do not rule out a scenario in which the EGB is dominated by emission from unresolved blazars, though unresolved star-forming galaxies may also contribute significantly to the background, within order-of-magnitude uncertainties. In addition, we find that the spectrum of the unresolved star-forming galaxy contribution cannot explain the EGB spectrum found by EGRET at energies between 50 and 200 MeV, whereas the spectrum of unresolved flat spectrum radio quasars, when accounting for the energy-dependent effects of source confusion, could be consistent with the combined spectrum of the low-energy EGRET EGB measurements and the Fermi-Large Area Telescope EGB measurements.

Analysis of major risk factors affecting those working in the agrarian sector (based on a sociological survey).

PubMed

Krekoten, Olena M; Dereziuk, Anatolii V; Ihnaschuk, Olena V; Holovchanska, Svitlana E

Issues related to labour potential, its state and problems have consistently been a focus of attention for the International Labour Organisation (ILO). Its respective analysis shows that labour potential problems remain unresolved in many countries of the world. According to the World Health Organisation (WHO), adverse working conditions are among major factors of occupational disease development in Europe and the reason for disabilities of economically active population during 2.5% of their lifetime. The aim of the present study is to identify and analyse major risk factors, which have a bearing on people working in agriculture in the course of exercising their occupation, with account of forms of ownership of agricultural enterprises. Carried out was a cross-sectional study involving a sociological survey of 412 respondents - those working in agriculture - who made up the primary group and the control group. The study revealed 21 risk factors, 9 of which were work-related. A modified elementary cybernetic model of studying impact efficiency was developed with the view of carrying out a structural analysis of the sample group and choosing relevant methodological approaches. It has been established that harmful factors related to working environment and one's lifestyle are decisive in the agrarian sector, particularly for workers of privately owned businesses. For one out of three respondents harmful working conditions manifested themselves as industrial noise (31.7±3.4), vibration (29.0±2.1) trunk bending and constrained working posture (36.6±3.4). The vast majority of agricultural workers (91.6±2.5) admitted they could not afford proper rest during their annual leave; male respondents abused alcohol (70.6±3.0) and smoking (41.4±2.0 per 100 workers). The research established the structure of risk factors, which is sequentially represented by the following groups: behavioral (smoking, drinking of alcohol, rest during annual leave, physical culture), working environment and work activities (occupation, work experience, safety measures, working environment, organization and management), socioeconomic (education, financial situation).

The Structure of Coronal Loops

NASA Technical Reports Server (NTRS)

Antiochos, Spiro K.

2009-01-01

It is widely believed that the simple coronal loops observed by XUV imagers, such as EIT, TRACE, or XRT, actually have a complex internal structure consisting of many (perhaps hundreds) of unresolved, interwoven "strands". According to the nanoflare model, photospheric motions tangle the strands, causing them to reconnect and release the energy required to produce the observed loop plasma. Although the strands, themselves, are unresolved by present-generation imagers, there is compelling evidence for their existence and for the nanoflare model from analysis of loop intensities and temporal evolution. A problem with this scenario is that, although reconnection can eliminate some of the strand tangles, it cannot destroy helicity, which should eventually build up to observable scales. we consider, therefore, the injection and evolution of helicity by the nanoflare process and its implications for the observed structure of loops and the large-scale corona. we argue that helicity does survive and build up to observable levels, but on spatial and temporal scales larger than those of coronal loops. we discuss the implications of these results for coronal loops and the corona, in general .

X-ray fluorescence microscopy artefacts in elemental maps of topologically complex samples: Analytical observations, simulation and a map correction method

NASA Astrophysics Data System (ADS)

Billè, Fulvio; Kourousias, George; Luchinat, Enrico; Kiskinova, Maya; Gianoncelli, Alessandra

2016-08-01

XRF spectroscopy is among the most widely used non-destructive techniques for elemental analysis. Despite the known angular dependence of X-ray fluorescence (XRF), topological artefacts remain an unresolved issue when using X-ray micro- or nano-probes. In this work we investigate the origin of the artefacts in XRF imaging of topologically complex samples, which are unresolved problems in studies of organic matter due to the limited travel distances of low energy XRF emission from the light elements. In particular we mapped Human Embryonic Kidney (HEK293T) cells. The exemplary results with biological samples, obtained with a soft X-ray scanning microscope installed at a synchrotron facility were used for testing a mathematical model based on detector response simulations, and for proposing an artefact correction method based on directional derivatives. Despite the peculiar and specific application, the methodology can be easily extended to hard X-rays and to set-ups with multi-array detector systems when the dimensions of surface reliefs are in the order of the probing beam size.

Shock and Awe. Achieving Rapid Dominance

DTIC Science & Technology

1996-09-01

par- adox of the issue of planning for a long - versus -short war in a nuclear world remained unresolved. 4 Shock and AweMobilization, as in World War...world and are likely to remain so for a long time to come. Why then, many will ask, should we examine and even propose major excursions and...after battle. Today, x we believe that an unusual opportunity exists to determine whether or not this long -sought strategic goal of affecting the

A decade of e-cigarettes: Limited research & unresolved safety concerns.

PubMed

Kaisar, Mohammad Abul; Prasad, Shikha; Liles, Tylor; Cucullo, Luca

2016-07-15

It is well known that tobacco consumption is a leading cause of preventable deaths worldwide and has been linked to major diseases ranging from cancer to chronic obstructive pulmonary disease, atherosclerosis, stroke and a host of neurological/neurodegenerative disorders. In the past decade a number of alternative vaping products have hit the market, rapidly gaining consumers especially among the younger population. Electronic nicotine delivery systems or e-cigarettes have become the sought-after product due to the belief that they are much safer than traditional cigarettes. However, inadequate research and lack of regulatory guidelines for both the manufacturing process and the content of the vaping solution of the e-cigarette has become a major concern. Highly debated and unresolved questions such as whether e-cigarettes may help smokers quit and whether e-cigarettes will promote the use of nicotine among non-smokers add to the confusion of the safety of e-cigarettes. In this review article, we summarize the current understanding (and lack thereof) of the potential health impacts of e-cigarettes. We will also highlight the most recent studies (in vivo/in vitro) which seem to conflict with the broad safety claims put forward by the manufacturers. Finally, we provide potential solutions to overcome the research gap of the short and long-term health impact of e-cigarettes. Published by Elsevier Ireland Ltd.

Coaching Family Caregivers to become Better Problem Solvers when Caring for Persons with Advanced Cancer

PubMed Central

Dionne-Odom, J. Nicholas; Lyons, Kathleen D.; Akyar, Imatullah; Bakitas, Marie

2016-01-01

Family caregivers of persons with advanced cancer often take on responsibilities that present daunting and complex problems. Serious problems that go unresolved may be burdensome and result in negative outcomes for caregivers’ psychological and physical health and affect the quality of care delivered to the care recipients with cancer, especially at the end of life. Formal problem-solving training approaches have been developed over the past several decades to assist individuals with managing problems faced in daily life. Several of these problem-solving principles and techniques were incorporated into ENABLE (Educate, Nurture, Advise, Before Life End), an ‘early’ palliative care telehealth intervention for individuals diagnosed with advanced cancer and their family caregivers. A hypothetical case resembling the situations of actual caregiver participants in ENABLE that exemplifies the complex problems that caregivers face is presented followed by presentation of an overview of ENABLE’s problem-solving key principles, techniques and steps in problem-solving support. Though more research is needed to formally test the use of problem-solving support in social work practice, social workers can easily incorporate these techniques into everyday practice. PMID:27143574

Can temporal fine structure represent the fundamental frequency of unresolved harmonics?

PubMed

Oxenham, Andrew J; Micheyl, Christophe; Keebler, Michael V

2009-04-01

At least two modes of pitch perception exist: in one, the fundamental frequency (F0) of harmonic complex tones is estimated using the temporal fine structure (TFS) of individual low-order resolved harmonics; in the other, F0 is derived from the temporal envelope of high-order unresolved harmonics that interact in the auditory periphery. Pitch is typically more accurate in the former than in the latter mode. Another possibility is that pitch can sometimes be coded via the TFS from unresolved harmonics. A recent study supporting this third possibility [Moore et al. (2006a). J. Acoust. Soc. Am. 119, 480-490] based its conclusion on a condition where phase interaction effects (implying unresolved harmonics) accompanied accurate F0 discrimination (implying TFS processing). The present study tests whether these results were influenced by audible distortion products. Experiment 1 replicated the original results, obtained using a low-level background noise. However, experiments 2-4 found no evidence for the use of TFS cues with unresolved harmonics when the background noise level was raised, or the stimulus level was lowered, to render distortion inaudible. Experiment 5 measured the presence and phase dependence of audible distortion products. The results provide no evidence that TFS cues are used to code the F0 of unresolved harmonics.

Unresolved trauma in mothers: intergenerational effects and the role of reorganization

PubMed Central

Iyengar, Udita; Kim, Sohye; Martinez, Sheila; Fonagy, Peter; Strathearn, Lane

2014-01-01

A mother's unresolved trauma may interfere with her ability to sensitively respond to her infant, thus affecting the development of attachment in her own child, and potentially contributing to the intergenerational transmission of trauma. One novel construct within the Dynamic Maturational Model of Attachment and Adaptation (DMM) coding of the Adult Attachment Interview (AAI) is “reorganization,” a process whereby speakers are actively changing their understanding of past and present experiences and moving toward attachment security. We conducted a study of mothers with unresolved trauma, exploring their own attachment classification, attachment outcomes of their children, and the potential effects of reorganization on child attachment. Forty-seven first-time mothers participated in the AAI during pregnancy, and returned with their child at 11 months to assess child attachment using the Strange Situation Procedure. Mothers with and without unresolved trauma were compared. We found that mothers with unresolved trauma had insecure attachment themselves and were more likely to have infants with insecure attachment. However, the one exception was that all of the mothers with unresolved trauma who were reorganizing toward secure attachment had infants with secure attachment. These preliminary findings suggest that mothers who are reorganizing may be able to more sensitively respond to their child's cues, contributing to the development of secure attachment. While our results need to be replicated in a larger cohort, this study is the first to explore the construct of reorganization and its potential relationship with child attachment. If confirmed in future studies, it may provide clinical insight into the intergenerational transmission of insecure attachment within the context of unresolved trauma. PMID:25225490

Sound vibration signal processing for detection and identification detonation (knock) to optimize performance Otto engine

NASA Astrophysics Data System (ADS)

Sujono, A.; Santoso, B.; Juwana, W. E.

2016-03-01

Problems of detonation (knock) on Otto engine (petrol engine) is completely unresolved problem until now, especially if want to improve the performance. This research did sound vibration signal processing engine with a microphone sensor, for the detection and identification of detonation. A microphone that can be mounted is not attached to the cylinder block, that's high temperature, so that its performance will be more stable, durable and inexpensive. However, the method of analysis is not very easy, because a lot of noise (interference). Therefore the use of new methods of pattern recognition, through filtration, and the regression function normalized envelope. The result is quite good, can achieve a success rate of about 95%.

Chapter 3. A multidimensional model for narrative analysis of substance use-related dependency.

PubMed

Larsson, Sam; von Braun, Therese; Lilja, John

2013-11-01

This chapter examines the possibilities and limitations of using a narrative method as a framework within a multidimensional model for exploring and analyzing the use and misuse of alcohol and drugs. It is posited that a multidimensional model, based on narrative reasoning, can give a more detailed and specific understanding of substance users, who represent a heterogeneous population of people, and of substance use-related dependency problems. Such a model describes and analyses the drug-use related problems in a manner that provides holistic and important information and knowledge about the person by contextual and situation interaction processes which are involved in the use/misuse of alcohol and drugs. Tentative conclusions and unresolved critical issues are considered.

Considerations in As analysis and speciation

USGS Publications Warehouse

Edwards, M.; Patel, S.; McNeil, L.; Chen, H.W.; Frey, M.; Eaton, A.D.; Antweiler, Ronald C.; Taylor, Howard E.

1998-01-01

This article summarizes recent experiences in arsenic (As) quantification, preservation, and speciation developed during AWWA Research Foundation (AWWARF) and Water Industry Technical Action Fund (WITAF) projects. The goal of this article is to alert analysts and decision-makers to potential problems in As analysis and speciation, because there appear to be several unresolved problems with routine analytical approaches. In true split drinking water samples As was quantified by three accepted analytical methods in three laboratories. The techniques used were graphite furnace atomic absorption spectrometry (GFAAS), inductively coupled plasma mass spectrometry (ICP-MS), and hydride generation inductively coupled plasma-emission spectrometry (HG-ICP-AES). Experimental findings are organized into sections on As analysis, particulate As in water supplies, and examination of As speciation methods.

Bunched black (and grouped grey) swans: Dissipative and non-dissipative models of correlated extreme fluctuations in complex geosystems

NASA Astrophysics Data System (ADS)

Watkins, N. W.

2013-01-01

I review the hierarchy of approaches to complex systems, focusing particularly on stochastic equations. I discuss how the main models advocated by the late Benoit Mandelbrot fit into this classification, and how they continue to contribute to cross-disciplinary approaches to the increasingly important problems of correlated extreme events and unresolved scales. The ideas have broad importance, with applications ranging across science areas as diverse as the heavy tailed distributions of intense rainfall in hydrology, after which Mandelbrot named the "Noah effect"; the problem of correlated runs of dry summers in climate, after which the "Joseph effect" was named; and the intermittent, bursty, volatility seen in finance and fluid turbulence.

Treatment of resistant insomnia and major depression.

PubMed

Vellante, F; Cornelio, M; Acciavatti, T; Cinosi, E; Marini, S; Dezi, S; De Risio, L; Di Iorio, G; Martinotti, G; Di Giannantonio, M

2013-01-01

Daily rhythms regulate everiday life and sleep/wake alternation is the best expression of this. Disruptions in biological rhythms is strongly associated with mood disorders, often being the major feature of this, major depressive disorder first of all. Although stabilization of rhythms produced by treatments have important outcome on therapeutic efficacy, insomnia often remains an unresolved symptom when major depression has otherwise been successfully treated with antidepressant. We review scientific literature in order to better clarify how to better approach insomnia as a clinical aspect to investigate and to early treat while treating other psychiatric conditions, major depression in particular. Insomnia is associated with impaired quality of life. It can be resolved with adequate diagnosis and treatment: it should be considered a comorbid condition and should be early identificated and treated in a multidisciplinary way, so that the ideal of treatment for patients with treatment resistant insomnia in major depression is an integration of non-pharmacologic measures, along with judicious use of medication, often used as an adjunctive therapy.

Sex allocation conflict in insect societies: who wins?

PubMed Central

Helanterä, Heikki; Ratnieks, Francis L. W.

2009-01-01

Sex allocation in colonies of eusocial Hymenoptera is one of the best studied social conflicts. We outline a framework for analysing conflict outcome through power and the costs of manipulation and suggest that the conflict will often be unresolved because both major parties of interest, the queen and the workers, should manipulate allocation even at considerable costs to the colony. We suggest future work for analysing power in the conflict between queen and workers over sex allocation and discuss the extent of male power. PMID:19656859

Paternal versus maternal coping styles with child diagnosis of developmental delay.

PubMed

Barak-Levy, Yael; Atzaba-Poria, Na'ama

2013-06-01

Parents of children with disabilities vary in their reaction to their children's diagnosis. The current study focused on fathers in addition to mothers and examined their resolution and coping styles when having children diagnosed with developmental delay (DD). Sixty-five fathers and 71 mothers were interviewed using the reaction to the diagnosis interview (RDI; Pianta & Marvin, 1992a). Results indicated that the majority of parents were unresolved with their child's diagnosis, with no differences found between fathers' and mothers' rates of resolution. Furthermore, both parents of children that were diagnosed at a later age and parents that were less educated tended to be unresolved, as did fathers of a lower socioeconomic status. Older age of both children and mothers was related to maternal lack of resolution. Finally, an in-depth examination revealed significant differences in the manner in which fathers and mothers cope with their children's diagnosis: whereas mothers were more prone to using an emotional coping style, fathers tended to use a cognitive coping style. The clinical implications of paternal versus maternal coping styles are discussed. Copyright © 2013 Elsevier Ltd. All rights reserved.

Variation across mitochondrial gene trees provides evidence for systematic error: How much gene tree variation is biological?

PubMed

Richards, Emilie J; Brown, Jeremy M; Barley, Anthony J; Chong, Rebecca A; Thomson, Robert C

2018-02-19

The use of large genomic datasets in phylogenetics has highlighted extensive topological variation across genes. Much of this discordance is assumed to result from biological processes. However, variation among gene trees can also be a consequence of systematic error driven by poor model fit, and the relative importance of biological versus methodological factors in explaining gene tree variation is a major unresolved question. Using mitochondrial genomes to control for biological causes of gene tree variation, we estimate the extent of gene tree discordance driven by systematic error and employ posterior prediction to highlight the role of model fit in producing this discordance. We find that the amount of discordance among mitochondrial gene trees is similar to the amount of discordance found in other studies that assume only biological causes of variation. This similarity suggests that the role of systematic error in generating gene tree variation is underappreciated and critical evaluation of fit between assumed models and the data used for inference is important for the resolution of unresolved phylogenetic questions.

How binarity affect the abundance discrepancy in planetary nebulae

NASA Astrophysics Data System (ADS)

García-Rojas, J.; Monteiro, H.; Jones, D.; Boffin, H.; Wesson, R.; Corradi, R.; Rodríguez-Gil, P.

2017-11-01

The discrepancy between chemical abundances computed using optical recombination lines (ORLs) and collisionally excited lines (CELs) is a major unresolved problem in nebular astrophysics, with significant implications for the determination of chemical abundances throughout the Universe. In planetary nebulae (PNe), a common explanation of this discrepancy is that two different gas phases coexist: a hot component with standard metallicity, and a much cooler plasma with a highly enhanced content of heavy elements. This dual nature is not predicted by mass loss theories, and observational support for it is still weak. We present recent findings which show that the largest abundance discrepancies (ADs) are reached in PNe with close binary central stars. Our last long-slit spectroscopic studies as well as direct imaging of the gas in the faint O II ORLs and high spatial resolution IFU spectroscopy support the fact that probably two different gas phases coexist in these nebulae and that high ADs should be explained in a framework of binary evolution. Although the exact scenario is still not understood, a promising proposal is that nova-like ejecta have a crucial role in the strong ORL emission in these objects.

Public reporting on quality, waiting times and patient experience in 11 high-income countries.

PubMed

Rechel, Bernd; McKee, Martin; Haas, Marion; Marchildon, Gregory P; Bousquet, Frederic; Blümel, Miriam; Geissler, Alexander; van Ginneken, Ewout; Ashton, Toni; Saunes, Ingrid Sperre; Anell, Anders; Quentin, Wilm; Saltman, Richard; Culler, Steven; Barnes, Andrew; Palm, Willy; Nolte, Ellen

2016-04-01

This article maps current approaches to public reporting on waiting times, patient experience and aggregate measures of quality and safety in 11 high-income countries (Australia, Canada, England, France, Germany, Netherlands, New Zealand, Norway, Sweden, Switzerland and the United States). Using a questionnaire-based survey of key national informants, we found that the data most commonly made available to the public are on waiting times for hospital treatment, being reported for major hospitals in seven countries. Information on patient experience at hospital level is also made available in many countries, but it is not generally available in respect of primary care services. Only one of the 11 countries (England) publishes composite measures of overall quality and safety of care that allow the ranking of providers of hospital care. Similarly, the publication of information on outcomes of individual physicians remains rare. We conclude that public reporting of aggregate measures of quality and safety, as well as of outcomes of individual physicians, remain relatively uncommon. This is likely to be due to both unresolved methodological and ethical problems and concerns that public reporting may lead to unintended consequences. Copyright © 2016 The Authors. Published by Elsevier Ireland Ltd.. All rights reserved.

A ten-year follow-up of human leptospirosis in Uruguay: an unresolved health problem.

PubMed

Schelotto, Felipe; Hernández, Elba; González, Sabina; Del Monte, Alicia; Ifran, Silvana; Flores, Karina; Pardo, Lorena; Parada, Daniel; Filippini, Mercedes; Balseiro, Victoria; Geymonat, Juan Pablo; Varela, Gustavo

2012-01-01

Leptospira spp. are delicate bacteria that cannot be studied by usual microbiological methods. They cause leptospirosis, a zoonotic disease transmitted to humans through infected urine of wild or domestic animals. We studied the incidence of this disease in the Uruguayan population, its epidemiologic and clinical features, and compared diagnostic techniques. After examining 6,778 suspect cases, we estimated that about 15 infections/100,000 inhabitants occurred yearly, affecting mainly young male rural workers. Awareness about leptospirosis has grown among health professionals, and its lethality has consequently decreased. Bovine infections were probably the principal source of human disease. Rainfall volumes and floods were major factors of varying incidence. Most patients had fever, asthenia, myalgias or cephalalgia, with at least one additional abnormal clinical feature. 30-40% of confirmed cases presented abdominal signs and symptoms, conjunctival suffusion and altered renal or urinary function. Jaundice was more frequent in patients aged > 40 years. Clinical infections followed an acute pattern and their usual outcome was complete recovery. Laboratory diagnosis was based on indirect micro-agglutination standard technique (MAT). Second serum samples were difficult to obtain, often impairing completion of diagnosis. Immunofluorescence was useful as a screening test and for early detection of probable infections.

Improvements in undergraduate oncology education introduced at Polish medical universities between 2004 and 2010 under Poland's "National Program for Combating Neoplastic Diseases".

PubMed

Matkowski, Rafał; Szelachowska, Jolanta; Szewczyk, Krzysztof; Staszek-Szewczyk, Urszula; Kornafel, Jan

2014-09-01

Cancer patient treatment in Poland remains unsatisfactory when compared to that in other countries. In 2005, this alarming situation prompted the Polish government to launch the "National Program for Combating Neoplastic Diseases" (NPCND). One part of this project was to improve the quality of oncology instruction at the undergraduate level over the years 2006 and 2007 (subsequently extended until 2010 thanks to promising results and the relatively small financial outlay). The program's main aims were to improve existing oncology therapy and to ameliorate the quality of undergraduate oncology education. To evaluate the changes in the quality of undergraduate education as a result of the NPCND program, medical universities were asked to fill out a questionnaire. Responses indicate that the program had a major positive impact on the quality of cancer education mainly as a result of the introduction of a uniform program of training and an increase in the number of classes devoted to oncology. The main unresolved problem is that university hospitals seldom have integrated units catering in-house for surgery, radiotherapy, chemotherapy, etc., and most such "hands-on" teaching still has to be done externally.

Ultralow threading dislocation density in GaN epilayer on near-strain-free GaN compliant buffer layer and its applications in hetero-epitaxial LEDs

PubMed Central

Shih, Huan-Yu; Shiojiri, Makoto; Chen, Ching-Hsiang; Yu, Sheng-Fu; Ko, Chung-Ting; Yang, Jer-Ren; Lin, Ray-Ming; Chen, Miin-Jang

2015-01-01

High threading dislocation (TD) density in GaN-based devices is a long unresolved problem because of the large lattice mismatch between GaN and the substrate, which causes a major obstacle for the further improvement of next-generation high-efficiency solid-state lighting and high-power electronics. Here, we report InGaN/GaN LEDs with ultralow TD density and improved efficiency on a sapphire substrate, on which a near strain-free GaN compliant buffer layer was grown by remote plasma atomic layer deposition. This “compliant” buffer layer is capable of relaxing strain due to the absorption of misfit dislocations in a region within ~10 nm from the interface, leading to a high-quality overlying GaN epilayer with an unusual TD density as low as 2.2 × 105 cm−2. In addition, this GaN compliant buffer layer exhibits excellent uniformity up to a 6” wafer, revealing a promising means to realize large-area GaN hetero-epitaxy for efficient LEDs and high-power transistors. PMID:26329829

The Dark Matter Crisis: Falsification of the Current Standard Model of Cosmology

NASA Astrophysics Data System (ADS)

Kroupa, P.

2012-06-01

The current standard model of cosmology (SMoC) requires The Dual Dwarf Galaxy Theorem to be true according to which two types of dwarf galaxies must exist: primordial dark-matter (DM) dominated (type A) dwarf galaxies, and tidal-dwarf and ram-pressure-dwarf (type B) galaxies void of DM. Type A dwarfs surround the host approximately spherically, while type B dwarfs are typically correlated in phase-space. Type B dwarfs must exist in any cosmological theory in which galaxies interact. Only one type of dwarf galaxy is observed to exist on the baryonic Tully-Fisher plot and in the radius-mass plane. The Milky Way satellite system forms a vast phase-space-correlated structure that includes globular clusters and stellar and gaseous streams. Other galaxies also have phase-space correlated satellite systems. Therefore, The Dual Dwarf Galaxy Theorem is falsified by observation and dynamically relevant cold or warm DM cannot exist. It is shown that the SMoC is incompatible with a large set of other extragalactic observations. Other theoretical solutions to cosmological observations exist. In particular, alone the empirical mass-discrepancy-acceleration correlation constitutes convincing evidence that galactic-scale dynamics must be Milgromian. Major problems with inflationary big bang cosmologies remain unresolved.

Morphology and Photometry of Isolated Seyfert Galaxies

NASA Astrophysics Data System (ADS)

Cracco, V.; Ciroi, S.; di Mille, F.; Omizzolo, A.; Funes, J. G.; Rafanelli, P.

2008-10-01

An unresolved and intriguing problem about active galactic nuclei is the mechanism responsible for nuclear triggering and fueling. Until now there is not a unique solution that can completely explain this phenomenon. We present preliminary results about morphological and photometric analysis of a sample of 35 nearby (z<0.035) and isolated Seyfert galaxies, observed through broad-band BVR filters at the 1.8-m Vatican Telescope and the 2.2-m ESO-La Silla Telescope. We analyzed photometric and morphological parameters and, using GALFIT software, we obtained two-dimensional decomposition of the luminosity profiles.

The Checkered History of American Psychiatric Epidemiology

PubMed Central

Horwitz, Allan V; Grob, Gerald N

2011-01-01

Context American psychiatry has been fascinated with statistics ever since the specialty was created in the early nineteenth century. Initially, psychiatrists hoped that statistics would reveal the benefits of institutional care. Nevertheless, their fascination with statistics was far removed from the growing importance of epidemiology generally. The impetus to create an epidemiology of mental disorders came from the emerging social sciences, whose members were concerned with developing a scientific understanding of individual and social behavior and applying it to a series of pressing social problems. Beginning in the 1920s, the interest of psychiatric epidemiologists shifted to the ways that social environments contributed to the development of mental disorders. This emphasis dramatically changed after 1980 when the policy focus of psychiatric epidemiology became the early identification and prevention of mental illness in individuals. Methods This article reviews the major developments in psychiatric epidemiology over the past century and a half. Findings The lack of an adequate classification system for mental illness has precluded the field of psychiatric epidemiology from providing causal understandings that could contribute to more adequate policies to remediate psychiatric disorders. Because of this gap, the policy influence of psychiatric epidemiology has stemmed more from institutional and ideological concerns than from knowledge about the causes of mental disorders. Conclusion Most of the problems that have bedeviled psychiatric epidemiology since its inception remain unresolved. In particular, until epidemiologists develop adequate methods to measure mental illnesses in community populations, the policy contributions of this field will not be fully realized. PMID:22188350

The viscous lee wave problem and its implications for ocean modelling

NASA Astrophysics Data System (ADS)

Shakespeare, Callum J.; Hogg, Andrew McC.

2017-05-01

Ocean circulation models employ 'turbulent' viscosity and diffusivity to represent unresolved sub-gridscale processes such as breaking internal waves. Computational power has now advanced sufficiently to permit regional ocean circulation models to be run at sufficiently high (100 m-1 km) horizontal resolution to resolve a significant part of the internal wave spectrum. Here we develop theory for boundary generated internal waves in such models, and in particular, where the waves dissipate their energy. We focus specifically on the steady lee wave problem where stationary waves are generated by a large-scale flow acting across ocean bottom topography. We generalise the energy flux expressions of [Bell, T., 1975. Topographically generated internal waves in the open ocean. J. Geophys. Res. 80, 320-327] to include the effect of arbitrary viscosity and diffusivity. Applying these results for realistic parameter choices we show that in the present generation of models with O(1) m2s-1 horizontal viscosity/diffusivity boundary-generated waves will inevitably dissipate the majority of their energy within a few hundred metres of the boundary. This dissipation is a direct consequence of the artificially high viscosity/diffusivity, which is not always physically justified in numerical models. Hence, caution is necessary in comparing model results to ocean observations. Our theory further predicts that O(10-2) m2s-1 horizontal and O(10-4) m2s-1 vertical viscosity/diffusivity is required to achieve a qualitatively inviscid representation of internal wave dynamics in ocean models.

Designing Efficient Self-Diagnosis Activities in the Physics Classroom

NASA Astrophysics Data System (ADS)

Safadi, Rafi'

2017-12-01

Self-diagnosis (SD) activities require students to self-diagnose their solutions to problems that they solved on their own. This involves identifying where they went wrong and then explaining the nature of their errors—why they went wrong—aided by some form of support. Worked examples (WEs) are often used to support students in SD activities. A WE is a step-by-step demonstration of how to solve a problem. One unresolved issue is why students fail to exploit WEs in SD exercises. Yerushalmi et al., for instance, provided students with written WEs and asked them to self-diagnose their solutions with respect to these WEs. These authors found no correlation between students' SD performance and their subsequent problem-solving performance on transfer problems, suggesting that students had only superficially exploited the written WEs. The aim of this article is to describe a new SD activity that was developed to prompt students to effectively use written WEs when self-diagnosing, and to examine its effectiveness in advancing students' learning in physics.

Unresolved grief and its consequences. A nationwide follow-up of teenage loss of a parent to cancer 6-9 years earlier.

PubMed

Bylund-Grenklo, T; Fürst, C J; Nyberg, T; Steineck, G; Kreicbergs, U

2016-07-01

The early loss of a parent is a tragedy and a serious life event. This study investigated grief resolution and morbidity in cancer-bereaved teenagers 6 to 9 years after the loss of a parent to cancer. In a nationwide population-based study of 622 of 851 (73 %) youths who as teenagers 6 to 9 years earlier had lost a parent to cancer, we explored the magnitude of unresolved grief and its association with psychological and physiological morbidity. Participants answered a study-specific anonymous questionnaire including questions about if they had worked through their grief and about their current health. Six to nine years post-loss 49 % reported unresolved grief (8 % no and 41 % a little grief resolution). They had, in comparison with youths reporting resolved grief, statistically significantly elevated risks, e.g. for insomnia (sons' relative risk (RR) 2.3, 95 % CI 1.3-4.0; daughters' RR 1.7, 95 % CI 1.1-2.7), fatigue (sons' RR 1.8, 95 % CI 1.3-2.5; daughters' RR 1.4, 95 % CI 1.1-1.7) and moderate to severe depression, i.e. score >9, PHQ-9 (sons' RR 3.6, 95 % CI 1.4-8.8; daughters' RR 1.8, 95 % CI 1.1-3.1). Associations remained for insomnia in sons, exhaustion in daughters and fatigue in both sons and daughters when depression, negative intrusive thoughts and avoiding reminders of the parents' disease or death were included in a model. Approximately half of cancer-bereaved youth report no or little grief resolution 6 to 9 years post-loss, which is associated with fatigue, sleeping problems and depressive symptoms.

Coalescent-Based Analyses of Genomic Sequence Data Provide a Robust Resolution of Phylogenetic Relationships among Major Groups of Gibbons

PubMed Central

Shi, Cheng-Min; Yang, Ziheng

2018-01-01

Abstract The phylogenetic relationships among extant gibbon species remain unresolved despite numerous efforts using morphological, behavorial, and genetic data and the sequencing of whole genomes. A major challenge in reconstructing the gibbon phylogeny is the radiative speciation process, which resulted in extremely short internal branches in the species phylogeny and extensive incomplete lineage sorting with extensive gene-tree heterogeneity across the genome. Here, we analyze two genomic-scale data sets, with ∼10,000 putative noncoding and exonic loci, respectively, to estimate the species tree for the major groups of gibbons. We used the Bayesian full-likelihood method bpp under the multispecies coalescent model, which naturally accommodates incomplete lineage sorting and uncertainties in the gene trees. For comparison, we included three heuristic coalescent-based methods (mp-est, SVDQuartets, and astral) as well as concatenation. From both data sets, we infer the phylogeny for the four extant gibbon genera to be (Hylobates, (Nomascus, (Hoolock, Symphalangus))). We used simulation guided by the real data to evaluate the accuracy of the methods used. Astral, while not as efficient as bpp, performed well in estimation of the species tree even in presence of excessive incomplete lineage sorting. Concatenation, mp-est and SVDQuartets were unreliable when the species tree contains very short internal branches. Likelihood ratio test of gene flow suggests a small amount of migration from Hylobates moloch to H. pileatus, while cross-genera migration is absent or rare. Our results highlight the utility of coalescent-based methods in addressing challenging species tree problems characterized by short internal branches and rampant gene tree-species tree discordance. PMID:29087487

Urinary tract infections in pregnancy: old and new unresolved diagnostic and therapeutic problems.

PubMed

Matuszkiewicz-Rowińska, Joanna; Małyszko, Jolanta; Wieliczko, Monika

2015-03-16

Urinary tract infections (UTIs) are common in pregnant women and pose a great therapeutic challenge, since the risk of serious complications in both the mother and her child is high. Pregnancy is a state associated with physiological, structural and functional urinary tract changes which promote ascending infections from the urethra. Unlike the general population, all pregnant women should be screened for bacteriuria with urine culture, and asymptomatic bacteriuria must be treated in every case that is diagnosed, as it is an important risk factor for pyelonephritis in this population. The antibiotic chosen should have a good maternal and fetal safety profile. In this paper, current principles of diagnosis and management of UTI in pregnancy are reviewed, and the main problems and controversies are identified and discussed.

A critique of principlism.

PubMed

Clouser, K D; Gert, B

1990-04-01

The authors use the term "principlism" to refer to the practice of using "principles" to replace both moral theory and particular moral rules and ideals in dealing with the moral problems that arise in medical practice. The authors argue that these "principles" do not function as claimed, and that their use is misleading both practically and theoretically. The "principles" are in fact not guides to action, but rather they are merely names for a collection of sometimes superficially related matters for consideration when dealing with a moral problem. The "principles" lack any systematic relationship to each other, and they often conflict with each other. These conflicts are unresolvable, since there is no unified moral theory from which they are all derived. For comparison the authors sketch the advantages of using a unified moral theory.

Urinary tract infections in pregnancy: old and new unresolved diagnostic and therapeutic problems

PubMed Central

Małyszko, Jolanta; Wieliczko, Monika

2015-01-01

Urinary tract infections (UTIs) are common in pregnant women and pose a great therapeutic challenge, since the risk of serious complications in both the mother and her child is high. Pregnancy is a state associated with physiological, structural and functional urinary tract changes which promote ascending infections from the urethra. Unlike the general population, all pregnant women should be screened for bacteriuria with urine culture, and asymptomatic bacteriuria must be treated in every case that is diagnosed, as it is an important risk factor for pyelonephritis in this population. The antibiotic chosen should have a good maternal and fetal safety profile. In this paper, current principles of diagnosis and management of UTI in pregnancy are reviewed, and the main problems and controversies are identified and discussed. PMID:25861291

Globalization and Health at the United States–Mexico Border

PubMed Central

Homedes, Núria; Ugalde, Antonio

2003-01-01

Objectives. We studied the impact of globalization on the making of health policy. Globalization is understood as economic interdependence among nations. The North American Free Trade Agreement is used as a marker to assess the effects of economic interdependence on binational health cooperation along the United States–Mexico border. Methods. We observed participants and conducted in-depth interviews with policymakers, public health specialists, representatives of professional organizations, and unions. Results. Globalization has not promoted binational health policy cooperation. Barriers that keep US and Mexican policymakers apart prevail while health problems that do not recognize international borders go unresolved. Conclusions. If international health problems are to be solved, political, cultural, and social interdependence need to be built with the same impetus by which policymakers promote international trade. PMID:14652325

Attachment stability and the emergence of unresolved representations during adolescence.

PubMed

Aikins, Julie Wargo; Howes, Carollee; Hamilton, Claire

2009-09-01

This 15-year longitudinal study examined the stability of attachment representations from infancy to adolescence and investigated the emergence of unresolved representations during adolescence in a sample of 47 16-year-olds. Attachment was assessed at 12 months using the Strange Situation Procedure, at 4 years using the modified Strange Situation Procedure, and again at 16 years with the Adult Attachment Projective (AAP). The emergence of unresolved classifications in adolescence (AAP) was associated with higher rates of negative life events, low levels of early mother-child relationship security (an aggregate measure of the 12-month and 4-year measures), negative teacher-child relationship experiences in middle childhood, and low early adolescent friendship quality. The results support the growing body of evidence suggesting that changes in attachment are lawful, while adding to the growing understanding of the emergence of unresolved attachment representations.

X-exome sequencing of 405 unresolved families identifies seven novel intellectual disability genes.

PubMed

Hu, H; Haas, S A; Chelly, J; Van Esch, H; Raynaud, M; de Brouwer, A P M; Weinert, S; Froyen, G; Frints, S G M; Laumonnier, F; Zemojtel, T; Love, M I; Richard, H; Emde, A-K; Bienek, M; Jensen, C; Hambrock, M; Fischer, U; Langnick, C; Feldkamp, M; Wissink-Lindhout, W; Lebrun, N; Castelnau, L; Rucci, J; Montjean, R; Dorseuil, O; Billuart, P; Stuhlmann, T; Shaw, M; Corbett, M A; Gardner, A; Willis-Owen, S; Tan, C; Friend, K L; Belet, S; van Roozendaal, K E P; Jimenez-Pocquet, M; Moizard, M-P; Ronce, N; Sun, R; O'Keeffe, S; Chenna, R; van Bömmel, A; Göke, J; Hackett, A; Field, M; Christie, L; Boyle, J; Haan, E; Nelson, J; Turner, G; Baynam, G; Gillessen-Kaesbach, G; Müller, U; Steinberger, D; Budny, B; Badura-Stronka, M; Latos-Bieleńska, A; Ousager, L B; Wieacker, P; Rodríguez Criado, G; Bondeson, M-L; Annerén, G; Dufke, A; Cohen, M; Van Maldergem, L; Vincent-Delorme, C; Echenne, B; Simon-Bouy, B; Kleefstra, T; Willemsen, M; Fryns, J-P; Devriendt, K; Ullmann, R; Vingron, M; Wrogemann, K; Wienker, T F; Tzschach, A; van Bokhoven, H; Gecz, J; Jentsch, T J; Chen, W; Ropers, H-H; Kalscheuer, V M

2016-01-01

X-linked intellectual disability (XLID) is a clinically and genetically heterogeneous disorder. During the past two decades in excess of 100 X-chromosome ID genes have been identified. Yet, a large number of families mapping to the X-chromosome remained unresolved suggesting that more XLID genes or loci are yet to be identified. Here, we have investigated 405 unresolved families with XLID. We employed massively parallel sequencing of all X-chromosome exons in the index males. The majority of these males were previously tested negative for copy number variations and for mutations in a subset of known XLID genes by Sanger sequencing. In total, 745 X-chromosomal genes were screened. After stringent filtering, a total of 1297 non-recurrent exonic variants remained for prioritization. Co-segregation analysis of potential clinically relevant changes revealed that 80 families (20%) carried pathogenic variants in established XLID genes. In 19 families, we detected likely causative protein truncating and missense variants in 7 novel and validated XLID genes (CLCN4, CNKSR2, FRMPD4, KLHL15, LAS1L, RLIM and USP27X) and potentially deleterious variants in 2 novel candidate XLID genes (CDK16 and TAF1). We show that the CLCN4 and CNKSR2 variants impair protein functions as indicated by electrophysiological studies and altered differentiation of cultured primary neurons from Clcn4(-/-) mice or after mRNA knock-down. The newly identified and candidate XLID proteins belong to pathways and networks with established roles in cognitive function and intellectual disability in particular. We suggest that systematic sequencing of all X-chromosomal genes in a cohort of patients with genetic evidence for X-chromosome locus involvement may resolve up to 58% of Fragile X-negative cases.

Development of an unresolved CFD-DEM model for the flow of viscous suspensions and its application to solid-liquid mixing

NASA Astrophysics Data System (ADS)

Blais, Bruno; Lassaigne, Manon; Goniva, Christoph; Fradette, Louis; Bertrand, François

2016-08-01

Although viscous solid-liquid mixing plays a key role in the industry, the vast majority of the literature on the mixing of suspensions is centered around the turbulent regime of operation. However, the laminar and transitional regimes face considerable challenges. In particular, it is important to know the minimum impeller speed (Njs) that guarantees the suspension of all particles. In addition, local information on the flow patterns is necessary to evaluate the quality of mixing and identify the presence of dead zones. Multiphase computational fluid dynamics (CFD) is a powerful tool that can be used to gain insight into local and macroscopic properties of mixing processes. Among the variety of numerical models available in the literature, which are reviewed in this work, unresolved CFD-DEM, which combines CFD for the fluid phase with the discrete element method (DEM) for the solid particles, is an interesting approach due to its accurate prediction of the granular dynamics and its capability to simulate large amounts of particles. In this work, the unresolved CFD-DEM method is extended to viscous solid-liquid flows. Different solid-liquid momentum coupling strategies, along with their stability criteria, are investigated and their accuracies are compared. Furthermore, it is shown that an additional sub-grid viscosity model is necessary to ensure the correct rheology of the suspensions. The proposed model is used to study solid-liquid mixing in a stirred tank equipped with a pitched blade turbine. It is validated qualitatively by comparing the particle distribution against experimental observations, and quantitatively by compairing the fraction of suspended solids with results obtained via the pressure gauge technique.

X-exome sequencing of 405 unresolved families identifies seven novel intellectual disability genes

PubMed Central

Hu, H; Haas, S A; Chelly, J; Van Esch, H; Raynaud, M; de Brouwer, A P M; Weinert, S; Froyen, G; Frints, S G M; Laumonnier, F; Zemojtel, T; Love, M I; Richard, H; Emde, A-K; Bienek, M; Jensen, C; Hambrock, M; Fischer, U; Langnick, C; Feldkamp, M; Wissink-Lindhout, W; Lebrun, N; Castelnau, L; Rucci, J; Montjean, R; Dorseuil, O; Billuart, P; Stuhlmann, T; Shaw, M; Corbett, M A; Gardner, A; Willis-Owen, S; Tan, C; Friend, K L; Belet, S; van Roozendaal, K E P; Jimenez-Pocquet, M; Moizard, M-P; Ronce, N; Sun, R; O'Keeffe, S; Chenna, R; van Bömmel, A; Göke, J; Hackett, A; Field, M; Christie, L; Boyle, J; Haan, E; Nelson, J; Turner, G; Baynam, G; Gillessen-Kaesbach, G; Müller, U; Steinberger, D; Budny, B; Badura-Stronka, M; Latos-Bieleńska, A; Ousager, L B; Wieacker, P; Rodríguez Criado, G; Bondeson, M-L; Annerén, G; Dufke, A; Cohen, M; Van Maldergem, L; Vincent-Delorme, C; Echenne, B; Simon-Bouy, B; Kleefstra, T; Willemsen, M; Fryns, J-P; Devriendt, K; Ullmann, R; Vingron, M; Wrogemann, K; Wienker, T F; Tzschach, A; van Bokhoven, H; Gecz, J; Jentsch, T J; Chen, W; Ropers, H-H; Kalscheuer, V M

2016-01-01

X-linked intellectual disability (XLID) is a clinically and genetically heterogeneous disorder. During the past two decades in excess of 100 X-chromosome ID genes have been identified. Yet, a large number of families mapping to the X-chromosome remained unresolved suggesting that more XLID genes or loci are yet to be identified. Here, we have investigated 405 unresolved families with XLID. We employed massively parallel sequencing of all X-chromosome exons in the index males. The majority of these males were previously tested negative for copy number variations and for mutations in a subset of known XLID genes by Sanger sequencing. In total, 745 X-chromosomal genes were screened. After stringent filtering, a total of 1297 non-recurrent exonic variants remained for prioritization. Co-segregation analysis of potential clinically relevant changes revealed that 80 families (20%) carried pathogenic variants in established XLID genes. In 19 families, we detected likely causative protein truncating and missense variants in 7 novel and validated XLID genes (CLCN4, CNKSR2, FRMPD4, KLHL15, LAS1L, RLIM and USP27X) and potentially deleterious variants in 2 novel candidate XLID genes (CDK16 and TAF1). We show that the CLCN4 and CNKSR2 variants impair protein functions as indicated by electrophysiological studies and altered differentiation of cultured primary neurons from Clcn4−/− mice or after mRNA knock-down. The newly identified and candidate XLID proteins belong to pathways and networks with established roles in cognitive function and intellectual disability in particular. We suggest that systematic sequencing of all X-chromosomal genes in a cohort of patients with genetic evidence for X-chromosome locus involvement may resolve up to 58% of Fragile X-negative cases. PMID:25644381

Attractor learning in synchronized chaotic systems in the presence of unresolved scales

NASA Astrophysics Data System (ADS)

Wiegerinck, W.; Selten, F. M.

2017-12-01

Recently, supermodels consisting of an ensemble of interacting models, synchronizing on a common solution, have been proposed as an alternative to the common non-interactive multi-model ensembles in order to improve climate predictions. The connection terms in the interacting ensemble are to be optimized based on the data. The supermodel approach has been successfully demonstrated in a number of simulation experiments with an assumed ground truth and a set of good, but imperfect models. The supermodels were optimized with respect to their short-term prediction error. Nevertheless, they produced long-term climatological behavior that was close to the long-term behavior of the assumed ground truth, even in cases where the long-term behavior of the imperfect models was very different. In these supermodel experiments, however, a perfect model class scenario was assumed, in which the ground truth and imperfect models belong to the same model class and only differ in parameter setting. In this paper, we consider the imperfect model class scenario, in which the ground truth model class is more complex than the model class of imperfect models due to unresolved scales. We perform two supermodel experiments in two toy problems. The first one consists of a chaotically driven Lorenz 63 oscillator ground truth and two Lorenz 63 oscillators with constant forcings as imperfect models. The second one is more realistic and consists of a global atmosphere model as ground truth and imperfect models that have perturbed parameters and reduced spatial resolution. In both problems, we find that supermodel optimization with respect to short-term prediction error can lead to a long-term climatological behavior that is worse than that of the imperfect models. However, we also show that attractor learning can remedy this problem, leading to supermodels with long-term behavior superior to the imperfect models.

Evidence for Unresolved Exoplanet-hosting Binaries in Gaia DR2

NASA Astrophysics Data System (ADS)

Evans, Daniel F.

2018-05-01

This note describes an effort to detect additional stellar sources in known transiting exoplanet (TEP) systems, which are unresolved or barely resolved in the Gaia Data Release 2 (DR2) catalogue. The presence of multiple unresolved stars in photometric and spectroscopic observations of a transiting planetary system biases measurements of the planet's radius, mass, and atmospheric conditions. In addition to the effect on individual planetary systems, the presence of unresolved stars across the sample of known exoplanets biases our overall understanding of planetary systems, due to the systematic underestimation of both masses and radii. This work uses the Astrometric Goodness of Fit in the Along-Scan direction (GOF_AL) and the Astrometric Excess Noise as indicators of poorly-resolved binaries. Many known close binaries in the exoplanet host star sample have highly significant GOF_AL and Astrometric Excess Noise values, such as WASP-20AB with Astrometric Excess Noise significant at $4720\\sigma$ and GOF_AL=124.

The closure problem for turbulence in meteorology and oceanography

NASA Technical Reports Server (NTRS)

Pierson, W. J., Jr.

1985-01-01

The dependent variables used for computer based meteorological predictions and in plans for oceanographic predictions are wave number and frequency filtered values that retain only scales resolvable by the model. Scales unresolvable by the grid in use become 'turbulence'. Whether or not properly processed data are used for initial values is important, especially for sparce data. Fickian diffusion with a constant eddy diffusion is used as a closure for many of the present models. A physically realistic closure based on more modern turbulence concepts, especially one with a reverse cascade at the right times and places, could help improve predictions.

Disordered communication and grieving in deaf member families.

PubMed

Sloman, L; Springer, S; Vachon, M L

1993-06-01

When a deaf child is born to hearing parents, a grieving process is initiated in the parents. Unresolved grieving over their child's deafness often makes it difficult for hearing parents to accept the importance of signing, thus increasing the child's problems--a further source of grief for these parents. Clinical illustrations are provided of (1) the reciprocal relationship between disruption of the mourning process and disturbance of communication between family members, and (2) the transmission of the dysfunctional relationship between hearing parents and deaf children to the subsequent relationship between the deaf children, when they reach adulthood, and their hearing children.

Trim and Structural Optimization of Subsonic Transport Wings Using Nonconventional Aeroelastic Tailoring

NASA Technical Reports Server (NTRS)

Stanford, Bret K.; Jutte, Christine V.

2014-01-01

Several minimum-mass aeroelastic optimization problems are solved to evaluate the effectiveness of a variety of novel tailoring schemes for subsonic transport wings. Aeroelastic strength and panel buckling constraints are imposed across a variety of trimmed maneuver loads. Tailoring with metallic thickness variations, functionally graded materials, composite laminates, tow steering, and distributed trailing edge control effectors are all found to provide reductions in structural wing mass with varying degrees of success. The question as to whether this wing mass reduction will offset the increased manufacturing cost is left unresolved for each case.

Genes, cells, and biobanks: Yes, there’s still a consent problem

PubMed Central

Murdoch, Blake

2017-01-01

From a research perspective, the interest in biobanking continues to intensify. Governments and industry have invested heavily in biobanks, as exemplified by initiatives like the United Kingdom Biobank and United States' Precision Medicine Initiative. But despite this enthusiasm, many profound legal and ethical challenges remain unresolved. Indeed, there continues to be disagreements about how best to obtain consent and the degree and nature of control that research participants retain over donated samples and health information. Emerging social trends—including concerns about commercialization and perceived rights of continuing control (“biorights”)—seem likely to intensify these issues. PMID:28742850

A Critical Appraisal of RAFT-Mediated Polymerization-Induced Self-Assembly

PubMed Central

2016-01-01

Recently, polymerization-induced self-assembly (PISA) has become widely recognized as a robust and efficient route to produce block copolymer nanoparticles of controlled size, morphology, and surface chemistry. Several reviews of this field have been published since 2012, but a substantial number of new papers have been published in the last three years. In this Perspective, we provide a critical appraisal of the various advantages offered by this approach, while also pointing out some of its current drawbacks. Promising future research directions as well as remaining technical challenges and unresolved problems are briefly highlighted. PMID:27019522

Multigrid techniques for unstructured meshes

NASA Technical Reports Server (NTRS)

Mavriplis, D. J.

1995-01-01

An overview of current multigrid techniques for unstructured meshes is given. The basic principles of the multigrid approach are first outlined. Application of these principles to unstructured mesh problems is then described, illustrating various different approaches, and giving examples of practical applications. Advanced multigrid topics, such as the use of algebraic multigrid methods, and the combination of multigrid techniques with adaptive meshing strategies are dealt with in subsequent sections. These represent current areas of research, and the unresolved issues are discussed. The presentation is organized in an educational manner, for readers familiar with computational fluid dynamics, wishing to learn more about current unstructured mesh techniques.

Crystal growth in a low gravity environment

NASA Technical Reports Server (NTRS)

Carruthers, J. R.

1977-01-01

Crystal growth in microgravity possesses several distinct technological advantages over earth-bound processes; containerless handling and reduction of density gradient driven as well as sedimentation flows. Experiments performed in space to date have been basically reproductions of processes currently used on earth and the results have clarified our understanding of crystal growth dynamics. In addition, both unresolved problems and areas requiring further study on earth have been identified. Future work in space processing of materials must address these areas of study as soon as possible if the full potential of a space environment to develop new techniques and materials is to be realized.

Eating disorders in adolescence: attachment issues from a developmental perspective

PubMed Central

Gander, Manuela; Sevecke, Kathrin; Buchheim, Anna

2015-01-01

In the present article we review findings from an emerging body of research on attachment issues in adolescents with eating disorders from a developmental perspective. Articles for inclusion in this review were identified from PsychINFO (1966–2013), Sciencedirect (1970–2013), Psychindex (1980–2013), and Pubmed (1980–2013). First, we will outline the crucial developmental changes in the attachment system and discuss how they might be related to the early onset of the disease. Then we will report on the major results from attachment studies using self-report and narrative instruments in that age group. Studies with a developmental approach on attachment will be analyzed in more detail. The high incidence of the unresolved attachment pattern in eating disorder samples is striking, especially for patients with anorexia nervosa. Interestingly, this predominance of the unresolved category was also found in their mothers. To date, these transgenerational aspects are still poorly understood and therefore represent an exciting research frontier. Future studies that include larger adolescent samples and provide a more detailed description including symptom severity and comorbidity would contribute to a better understanding of this complex and painful condition. PMID:26321974

[Tuberculosis and diabetes co-morbidity: an unresolved problem].

PubMed

Ugarte-Gil, César; Moore, David A J

2014-01-01

Co-morbidity between tuberculosis and diabetes has been described since the early 20th century. In developed countries, where there has been a decrease of infectious diseases with an increase of non-communicable diseases, as well as those countries who still have a high prevalence of infectious diseases but an increase of non-communicable diseases, it is observed that the prevalence of co-morbidity between tuberculosis and diabetes is increasing, making clinical management and control at the public health level a new challenge for health systems. This review aims to show the current available evidence that can inform research lines being developed to understand the problem. In countries like Peru, where there is an epidemiological transition, further research could allow us to understand and describe in a better way the characteristics and impact of this co-morbidity.

28 CFR 42.610 - Agency enforcement of unresolved complaints.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 28 Judicial Administration 1 2014-07-01 2014-07-01 false Agency enforcement of unresolved complaints. 42.610 Section 42.610 Judicial Administration DEPARTMENT OF JUSTICE NONDISCRIMINATION; EQUAL EMPLOYMENT OPPORTUNITY; POLICIES AND PROCEDURES Procedures for Complaints of Employment Discrimination Filed...

Green primaries: Environmentally friendly energetic complexes

PubMed Central

Huynh, My Hang V.; Hiskey, Michael A.; Meyer, Thomas J.; Wetzler, Modi

2006-01-01

Primary explosives are used in small quantities to generate a detonation wave when subjected to a flame, heat, impact, electric spark, or friction. Detonation of the primary explosive initiates the secondary booster or main-charge explosive or propellant. Long-term use of lead azide and lead styphnate as primary explosives has resulted in lead contamination at artillery and firing ranges and become a major health hazard and environmental problem for both military and civilian personnel. Devices using lead primary explosives are manufactured by the tens of millions every year in the United States from primers for bullets to detonators for mining. Although substantial synthetic efforts have long been focused on the search for greener primary explosives, this unresolved problem has become a “holy grail” of energetic materials research. Existing candidates suffer from instability or excessive sensitivity, or they possess toxic metals or perchlorate. We report here four previously undescribed green primary explosives based on complex metal dianions and environmentally benign cations, (cat)2[MII(NT)4(H2O)2] (where cat is NH4+ or Na+, M is Fe2+ or Cu2+, and NT− is 5-nitrotetrazolato-N2). They are safer to prepare, handle, and transport than lead compounds, have comparable initiation efficiencies to lead azide, and offer rapid reliable detonation comparable with lead styphnate. Remarkably, they possess all current requirements for green primary explosives and are suitable to replace lead primary explosives in detonators. More importantly, they can be synthesized more safely, do not pose health risks to personnel, and cause much less pollution to the environment. PMID:16567623

The Nature of the Unresolved Extragalactic Cosmic Soft X-Ray Background

NASA Technical Reports Server (NTRS)

Cappelluti, N.; Ranalli, P.; Roncarelli, M.; Arevalo, P.; Zamorani, G.; Comastri, A.; Gilli, R.; Rovilos, E.; Vignali, C.; Allevato, V.;

Unresolved Problems by Shock Capturing: Taming the Overheating Problem

NASA Technical Reports Server (NTRS)

Liou, Meng-Sing

2012-01-01

The overheating problem, first observed by von Neumann [1] and later studied extensively by Noh [2] using both Eulerian and Lagrangian formulations, remains to be one of the unsolved problems by shock capturing. It is historically well known to occur when a flow is under compression, such as when a shock wave hits and reflects from a wall or when two streams collides with each other. The overheating phenomenon is also found numerically in a smooth flow undergoing rarefaction created by two streams receding from each other. This is in contrary to one s intuition expecting a decrease in internal energy. The excessive amount in the temperature increase does not reduce by refining the mesh size or increasing the order of accuracy. This study finds that the overheating in the receding flow correlates with the entropy generation. By requiring entropy preservation, the overheating is eliminated and the solution is grid convergent. The shock-capturing scheme, as being practiced today, gives rise to the entropy generation, which in turn causes the overheating. This assertion stands up to the convergence test.

Assessing the role of relationship conflict in sexual dysfunction.

PubMed

Metz, Michael E; Epstein, Norman

2002-01-01

Relationship conflict has long been thought to cause, maintain, and influence the therapeutic outcome of sexual problems in the absence of a physical cause. The results of conflict can influence partners' relationship satisfaction, and relationship satisfaction can influence sexual satisfaction. General relationship deficiencies, such as unresolved conflict, undermine the mutual acceptance that is important to healthy sexual functioning. The purpose of this article is to summarize some of the basic empirical findings of studies of conflict patterns in relationships and their role in sex dysfunction and to suggest a model for assessing relationship conflict as a feature of sexual dysfunction. Results from several studies indicate that couples with sexual problems may have conflict-management issues and employ distinct conflict-resolution styles compared to satisfied couples. Dysfunctional conflict resolution may be a cause or result of some sexual problems, whereas constructive interaction concerning conflict can add to emotional and sexual intimacy in a couple's relationship. These patterns warrant systematic attention in assessment and intervention in sex therapy.

Constraining DALECv2 using multiple data streams and ecological constraints: analysis and application

DOE PAGES

Delahaies, Sylvain; Roulstone, Ian; Nichols, Nancy

2017-07-10

We use a variational method to assimilate multiple data streams into the terrestrial ecosystem carbon cycle model DALECv2 (Data Assimilation Linked Ecosystem Carbon). Ecological and dynamical constraints have recently been introduced to constrain unresolved components of this otherwise ill-posed problem. We recast these constraints as a multivariate Gaussian distribution to incorporate them into the variational framework and we demonstrate their advantage through a linear analysis. By using an adjoint method we study a linear approximation of the inverse problem: firstly we perform a sensitivity analysis of the different outputs under consideration, and secondly we use the concept of resolution matricesmore » to diagnose the nature of the ill-posedness and evaluate regularisation strategies. We then study the non-linear problem with an application to real data. Finally, we propose a modification to the model: introducing a spin-up period provides us with a built-in formulation of some ecological constraints which facilitates the variational approach.« less

Constraining DALECv2 using multiple data streams and ecological constraints: analysis and application

DOE Office of Scientific and Technical Information (OSTI.GOV)

Delahaies, Sylvain; Roulstone, Ian; Nichols, Nancy

We use a variational method to assimilate multiple data streams into the terrestrial ecosystem carbon cycle model DALECv2 (Data Assimilation Linked Ecosystem Carbon). Ecological and dynamical constraints have recently been introduced to constrain unresolved components of this otherwise ill-posed problem. We recast these constraints as a multivariate Gaussian distribution to incorporate them into the variational framework and we demonstrate their advantage through a linear analysis. By using an adjoint method we study a linear approximation of the inverse problem: firstly we perform a sensitivity analysis of the different outputs under consideration, and secondly we use the concept of resolution matricesmore » to diagnose the nature of the ill-posedness and evaluate regularisation strategies. We then study the non-linear problem with an application to real data. Finally, we propose a modification to the model: introducing a spin-up period provides us with a built-in formulation of some ecological constraints which facilitates the variational approach.« less

Thirty Years of Nearshore Research

NASA Astrophysics Data System (ADS)

Stanton, T. P.

2006-12-01

An assessment of Ed Thornton's contributions to nearshore wave, current and morphology research on the eve of his retirement reveals his ability to identify important unresolved processes, and to participate in multidisciplinary research programs that address those issues. While doing this, he has consistently helped foster the new generations of field scientists both by supervising strong masters and PhD students from around the world, and through working with successful postdoctoral students, many of whom will present talks in this session. This presentation will summarize the major field programs that he has very actively participated in starting from my first field work with him as a colleague/helper in the NSTS Blacks Beach and Santa Barbara experiments. In reviewing these experiments it is interesting to see the evolution of our understanding of the surf zone from simplified 2D wave breaking processes to the 3D wave/current/sediment transport problems seen in morphologically controlled rip currents, both through our ability to measure these processes, but also in the sophistication of numerical models of the nearshore. This review also shows how the consistent and well directed basic research funding from the Coastal Geosciences program at ONR has greatly benefited the Navy and the community at large. I know the nearshore community looks forward to continued associations with him during his very active retirement.

Routine and timely sub-picoNewton force stability and precision for biological applications of atomic force microscopy.

PubMed

Churnside, Allison B; Sullan, Ruby May A; Nguyen, Duc M; Case, Sara O; Bull, Matthew S; King, Gavin M; Perkins, Thomas T

2012-07-11

Force drift is a significant, yet unresolved, problem in atomic force microscopy (AFM). We show that the primary source of force drift for a popular class of cantilevers is their gold coating, even though they are coated on both sides to minimize drift. Drift of the zero-force position of the cantilever was reduced from 900 nm for gold-coated cantilevers to 70 nm (N = 10; rms) for uncoated cantilevers over the first 2 h after wetting the tip; a majority of these uncoated cantilevers (60%) showed significantly less drift (12 nm, rms). Removing the gold also led to ∼10-fold reduction in reflected light, yet short-term (0.1-10 s) force precision improved. Moreover, improved force precision did not require extended settling; most of the cantilevers tested (9 out of 15) achieved sub-pN force precision (0.54 ± 0.02 pN) over a broad bandwidth (0.01-10 Hz) just 30 min after loading. Finally, this precision was maintained while stretching DNA. Hence, removing gold enables both routine and timely access to sub-pN force precision in liquid over extended periods (100 s). We expect that many current and future applications of AFM can immediately benefit from these improvements in force stability and precision.

On the classification of normally distributed neurons: an application to human dentate nucleus.

PubMed

Ristanović, Dušan; Milošević, Nebojša T; Marić, Dušica L

2011-03-01

One of the major goals in cellular neurobiology is the meaningful cell classification. However, in cell classification there are many unresolved issues that need to be addressed. Neuronal classification usually starts with grouping cells into classes according to their main morphological features. If one tries to test quantitatively such a qualitative classification, a considerable overlap in cell types often appears. There is little published information on it. In order to remove the above-mentioned shortcoming, we undertook the present study with the aim to offer a novel method for solving the class overlapping problem. To illustrate our method, we analyzed a sample of 124 neurons from adult human dentate nucleus. Among them we qualitatively selected 55 neurons with small dendritic fields (the small neurons), and 69 asymmetrical neurons with large dendritic fields (the large neurons). We showed that these two samples are normally and independently distributed. By measuring the neuronal soma areas of both samples, we observed that the corresponding normal curves cut each other. We proved that the abscissa of the point of intersection of the curves could represent the boundary between the two adjacent overlapping neuronal classes, since the error done by such division is minimal. Statistical evaluation of the division was also performed.

Implantation of preadipocyte-loaded hyaluronic acid-based scaffolds into nude mice to evaluate potential for soft tissue engineering.

PubMed

Hemmrich, Karsten; von Heimburg, Dennis; Rendchen, Raoul; Di Bartolo, Chiara; Milella, Eva; Pallua, Norbert

2005-12-01

The reconstruction of soft tissue defects following extensive deep burns or tumor resections remains an unresolved problem in plastic and reconstructive surgery since adequate implant materials are still not available. Preadipocytes, immature precursor cells found between mature adipocytes in adipose tissue, are a potential material for soft tissue engineering since they can proliferate and differentiate into adipose tissue after transplantation. In previous studies, we identified hyaluronan benzyl ester (HYAFF 11) sponges to be promising carrier matrices. This study now evaluates, in vitro and in vivo, a new sponge architecture with pores of 400 microm either made of plain HYAFF 11 or HYAFF 11 coated with the extracellular matrix glycosaminoglycan hyaluronic acid. Human preadipocytes were isolated, seeded onto carriers and implanted into nude athymic mice. Explants harvested after 3, 8, and 12 weeks were examined for macroscopical appearance, thickness, weight, pore structure, histology, and immunohistochemistry. Compared to previous studies, we found better penetration of cells into both types of scaffolds, with more extensive formation of new vessels throughout the construct but with only minor adipose tissue. Our encouraging results contribute towards a better seeded and vascularised scaffold but also show that the enhancement of adipogenic conversion of preadipocytes remains a major task for further in vivo experiments.

The use of strain gauge platform and virtual reality tool for patient stability examination

NASA Astrophysics Data System (ADS)

Walendziuk, Wojciech; Wysk, Lukasz; Skoczylas, Marcin

2016-09-01

Virtual reality is one of the fastest growing information technologies. This paper is only a prelude to a larger study on the use of virtual reality tools in analysing bony labyrinth and sense of balance. Problems with the functioning of these areas of the body are a controversial topic in debate among specialists. The result of still unresolved imbalance treatments is a constant number of people reporting this type of ailment. Considering above, authors created a system and application that contains a model of virtual environment, and a tool for the modification of the obstacles in 3D space. Preliminary studies of patients from a test group aged 22-49 years were also carried out, in which behaviour and sense of balance in relation to the horizontal curvature of the virtual world around patient has been analysed. Experiments carried out on a test group showed that the shape of the curve and the virtual world space and age of patient has a major impact on a sense of balance. The data obtained can be linked with actual disorders of bony labyrinth and human behaviour at the time of their occurrence. Another important achievement that will be the subject of further work is possible use a modified version of the software for rehabilitation purposes.

The Prevalence of Human Papillomavirus between the Neonates and Their Mothers

PubMed Central

Skoczyński, Mariusz; Goździcka-Józefiak, Anna; Kwaśniewska, Anna

2015-01-01

The impact of human papillomavirus (HPV) infection on pregnancy is a major problem of medicine. The transmission of the virus from mother to fetus is a process yet unresolved. The immune response and changed hormonal status of pregnant women might facilitate infection. A research on the prevalence of HPV infection was conducted at the Clinic of Obstetrics, Medical University of Lublin (Poland). The studied group included 152 randomly selected women. The material was tested for the presence of HPV DNA by means of polymerase chain reaction (PCR). The aim of the research was to assess the relation between HPV infections detected in the buccal smears of the neonates and the incidence of such infections in the cervical/buccal smears of their mothers. In the group of 152 infants HPV was found in 16 (10.53%). Among the cervical/buccal smears, HPV was isolated, respectively, in 24 (15.79%) and in 19 (12.5%) pregnant women. Statistically significant differences in the prevalence of HPV swabs from the newborns and the cervical/buccal smears of their mothers were found (p < 0.001). The identification of mothers in whose buccal smears HPV was detected can help develop a group of children who run a relatively significant risk of being infected. PMID:26713313

Dissecting the Impact of Chemotherapy on the Human Hair Follicle

PubMed Central

Bodó, Enikő; Tobin, Desmond J.; Kamenisch, York; Bíró, Tamás; Berneburg, Mark; Funk, Wolfgang; Paus, Ralf

2007-01-01

Chemotherapy-induced alopecia represents one of the major unresolved problems of clinical oncology. The underlying molecular pathogenesis in humans is virtually unknown because of the lack of adequate research models. Therefore, we have explored whether microdissected, organ-cultured, human scalp hair follicles (HFs) in anagen VI can be exploited for dissecting and manipulating the impact of chemotherapy on human HFs. Here, we show that these organ-cultured HFs respond to a key cyclophosphamide metabolite, 4-hydroperoxycyclophosphamide (4-HC), in a manner that resembles chemotherapy-induced HF dystrophy as it occurs in vivo: namely, 4-HC induced melanin clumping and melanin incontinence, down-regulated keratinocyte proliferation, massively up-regulated apoptosis of hair matrix keratinocytes, prematurely induced catagen, and up-regulated p53. In addition, 4-HC induced DNA oxidation and the mitochondrial DNA common deletion. The organ culture system facilitated the identification of new molecular targets for chemotherapy-induced HF damage by microarray technology (eg, interleukin-8, fibroblast growth factor-18, and glypican 6). It was also used to explore candidate chemotherapy protectants, for which we used the cytoprotective cytokine keratinocyte growth factor as exemplary pilot agent. Thus, this novel system serves as a powerful yet pragmatic tool for dissecting and manipulating the impact of chemotherapy on the human HF. PMID:17823286

Reverse Mössbauer effect as a possible source of “hot” molecules absorbed in crystalline solids at low temperature

DOE Office of Scientific and Technical Information (OSTI.GOV)

Demontis, Pierfranco; Suffritti, Giuseppe B., E-mail: pino@uniss.it

2016-09-07

As an attempt to explain some of the many anomalies and unresolved problems which have been reported about the dynamic behavior of particles and molecules absorbed in crystalline solids, the “reverse Mössbauer effect” (RME) is proposed. RME theory posits that a particle in non-equilibrium state with respect to a crystal (colliding with the crystal or absorbed in it, but set out of thermal equilibrium by some external cause) is scattered by the whole crystal with a momentum proportional to a vector representing a reciprocal lattice point. The scattering is expected to occur with a well-defined probability and the momentum transferablemore » to the particle is expected to follow a predictable distribution. The RME theory, in practice, is an extension of the Bragg–von Laue scattering law to high-energy colliding particles, in general, and can be applied to any particle or molecule colliding with the surface of a crystalline solid or absorbed in it, but not in thermal equilibrium with the crystal lattice. We verified the RME theory by considering a well-defined unresolved problem. In an experimental study about methane adsorbed in the zeolite Na-ZSM-5 [H. Jobic, Chem. Phys. Lett. 170, 217 (1990)] reporting neutron inelastic-scattering spectra (recoiled bands) at 10 K, the translational kinetic energy of methane resulted to be much higher than equilibrium expected value, namely, about 85 K (or 7.3 meV). The author concluded that “the interpretation of this unusual behavior has yet to be found.” In the present study, on the basis of the RME, an explanation of this behavior is put forward.« less

Individual Differences, Intelligence, and Behavior Analysis

PubMed Central

Williams, Ben; Myerson, Joel; Hale, Sandra

2008-01-01

Despite its avowed goal of understanding individual behavior, the field of behavior analysis has largely ignored the determinants of consistent differences in level of performance among individuals. The present article discusses major findings in the study of individual differences in intelligence from the conceptual framework of a functional analysis of behavior. In addition to general intelligence, we discuss three other major aspects of behavior in which individuals differ: speed of processing, working memory, and the learning of three-term contingencies. Despite recent progress in our understanding of the relations among these aspects of behavior, numerous issues remain unresolved. Researchers need to determine which learning tasks predict individual differences in intelligence and which do not, and then identify the specific characteristics of these tasks that make such prediction possible. PMID:18831127

Detecting unresolved binary stars in Euclid VIS images

NASA Astrophysics Data System (ADS)

Kuntzer, T.; Courbin, F.

2017-10-01

Measuring a weak gravitational lensing signal to the level required by the next generation of space-based surveys demands exquisite reconstruction of the point-spread function (PSF). However, unresolved binary stars can significantly distort the PSF shape. In an effort to mitigate this bias, we aim at detecting unresolved binaries in realistic Euclid stellar populations. We tested methods in numerical experiments where (I) the PSF shape is known to Euclid requirements across the field of view; and (II) the PSF shape is unknown. We drew simulated catalogues of PSF shapes for this proof-of-concept paper. Following the Euclid survey plan, the objects were observed four times. We propose three methods to detect unresolved binary stars. The detection is based on the systematic and correlated biases between exposures of the same object. One method is a simple correlation analysis, while the two others use supervised machine-learning algorithms (random forest and artificial neural network). In both experiments, we demonstrate the ability of our methods to detect unresolved binary stars in simulated catalogues. The performance depends on the level of prior knowledge of the PSF shape and the shape measurement errors. Good detection performances are observed in both experiments. Full complexity, in terms of the images and the survey design, is not included, but key aspects of a more mature pipeline are discussed. Finding unresolved binaries in objects used for PSF reconstruction increases the quality of the PSF determination at arbitrary positions. We show, using different approaches, that we are able to detect at least binary stars that are most damaging for the PSF reconstruction process. The code corresponding to the algorithms used in this work and all scripts to reproduce the results are publicly available from a GitHub repository accessible via http://lastro.epfl.ch/software

Chirality and protein biosynthesis.

PubMed

Banik, Sindrila Dutta; Nandi, Nilashis

2013-01-01

Chirality is present at all levels of structural hierarchy of protein and plays a significant role in protein biosynthesis. The macromolecules involved in protein biosynthesis such as aminoacyl tRNA synthetase and ribosome have chiral subunits. Despite the omnipresence of chirality in the biosynthetic pathway, its origin, role in current pathway, and importance is far from understood. In this review we first present an introduction to biochirality and its relevance to protein biosynthesis. Major propositions about the prebiotic origin of biomolecules are presented with particular reference to proteins and nucleic acids. The problem of the origin of homochirality is unresolved at present. The chiral discrimination by enzymes involved in protein synthesis is essential for keeping the life process going. However, questions remained pertaining to the mechanism of chiral discrimination and concomitant retention of biochirality. We discuss the experimental evidence which shows that it is virtually impossible to incorporate D-amino acids in protein structures in present biosynthetic pathways via any of the two major steps of protein synthesis, namely aminoacylation and peptide bond formation reactions. Molecular level explanations of the stringent chiral specificity in each step are extended based on computational analysis. A detailed account of the current state of understanding of the mechanism of chiral discrimination during aminoacylation in the active site of aminoacyl tRNA synthetase and peptide bond formation in ribosomal peptidyl transferase center is presented. Finally, it is pointed out that the understanding of the mechanism of retention of enantiopurity has implications in developing novel enzyme mimetic systems and biocatalysts and might be useful in chiral drug design.

Massive dysregulation of genes involved in cell signaling and placental development in cloned cattle conceptus and maternal endometrium

PubMed Central

Biase, Fernando H.; Rabel, Chanaka; Guillomot, Michel; Hue, Isabelle; Andropolis, Kalista; Olmstead, Colleen A.; Oliveira, Rosane; Wallace, Richard; Le Bourhis, Daniel; Richard, Christophe; Campion, Evelyne; Chaulot-Talmon, Aurélie; Giraud-Delville, Corinne; Taghouti, Géraldine; Jammes, Hélène; Renard, Jean-Paul; Sandra, Olivier; Lewin, Harris A.

2016-01-01

A major unresolved issue in the cloning of mammals by somatic cell nuclear transfer (SCNT) is the mechanism by which the process fails after embryos are transferred to the uterus of recipients before or during the implantation window. We investigated this problem by using RNA sequencing (RNA-seq) to compare the transcriptomes in cattle conceptuses produced by SCNT and artificial insemination (AI) at day (d) 18 (preimplantation) and d 34 (postimplantation) of gestation. In addition, endometrium was profiled to identify the communication pathways that might be affected by the presence of a cloned conceptus, ultimately leading to mortality before or during the implantation window. At d 18, the effects on the transcriptome associated with SCNT were massive, involving more than 5,000 differentially expressed genes (DEGs). Among them are 121 genes that have embryonic lethal phenotypes in mice, cause defects in trophoblast and placental development, and/or affect conceptus survival in mice. In endometria at d 18, <0.4% of expressed genes were affected by the presence of a cloned conceptus, whereas at d 34, ∼36% and <0.7% of genes were differentially expressed in intercaruncular and caruncular tissues, respectively. Functional analysis of DEGs in placental and endometrial tissues suggests a major disruption of signaling between the cloned conceptus and the endometrium, particularly the intercaruncular tissue. Our results support a “bottleneck” model for cloned conceptus survival during the periimplantation period determined by gene expression levels in extraembryonic tissues and the endometrial response to altered signaling from clones. PMID:27940919

The Role of Social Workers in Spiritual Care to Facilitate Coping With Chronic Illness and Self-Determination in Advance Care Planning.

PubMed

Francoeur, Richard B; Burke, Nancy; Wilson, Alicia M

2016-01-01

Spiritual values and beliefs of patients and families influence resilience during chronic illness and shape patient choices during advance care planning. The spiritual needs of Baby Boomers will be more diverse than previous generations, in connection with the questioning, experimental mind-set of this group and the fact that it includes a higher proportion of immigrant populations outside the Judeo-Christian tradition. Social workers are trained explicitly to intervene with diverse populations and are well positioned to offer spiritual support in ways that do not necessarily conform to traditional religions. To the extent of their individual expertise and competence, social workers should assess and provide spiritual care to clients, including those who either are underserved or prefer not to seek assistance from clergy or chaplains because they feel alienated from religious institutions and representatives. They should also be aware of ethical dilemmas in consulting with spiritual care professionals in developing spiritual interventions. Social work education should address clients' humanistic and existential concerns, beliefs and behaviors of the major religions, and forms of nontraditional religious and spiritual experiences; it should also provide experiential opportunities for engaging with grief and earlier advance care planning. There should be attention to different theodical perspectives of the major religions regarding the problem of good and evil, which may preoccupy even clients who no longer participate in organized religion, because these unresolved existential issues may weaken client coping with chronic conditions and may diminish clarity and self-awareness for engaging authentically and effectively in advance care planning.

Oil, the Arab--Israel dispute, and the industrial world: horizons of crisis. [Book: 20 papers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hurewitz, J.C.

1976-01-01

This book is the product of a multinational project, sponsored by the Middle East Institute of Columbia University in cooperation with the World Peace Foundation (Boston), the Atlantic Institute for Internal Affairs (Paris), and the Asia-Pacific Association of Japan (Tokyo). It focuses on the principal unresolved issues of the energy crisis, the Arab-Israel dispute, and their tangled effects that feed back to and feed upon relations with the North Atlantic countries and Japan. Since almost all the papers were originally presented for discussion to three study groups--North American (US and Canada), Western European, and Japanese--it was possible to assess themore » domestic interests and pressures that inhibit and those that promote cooperation among the major nonsocialist industrial states and to illuminate the linkages between the domestic influences and the national policymaking processes. This symposium comes into focus as a study, not of one issue, but of the intersection of three. For analytical purposes, the energy crisis and the Arab-Israel dispute are decoupled. The decoupled analysis forms the subject matter of the first two parts of the book. Thereafter, the Middle East problem of popular perception is reconstituted. The chapters of the third part inquire into major effects in the Middle East of the mixing of oil and politics and speculate on likely developments in the coming decade of this still potent mixture. The fourth part considers primary aspects of the evolving patterns of international political economy, as influenced by the energy crisis or its linkage to the Arab-Israel dispute.« less

Extrinsic and Intrinsic Motivation at 30: Unresolved Scientific Issues

ERIC Educational Resources Information Center

Reiss, Steven

2005-01-01

The undermining effect of extrinsic reward on intrinsic motivation remains unproven. The key unresolved issues are construct invalidity (all four definitions are unproved and two are illogical); measurement unreliability (the free-choice measure requires unreliable, subjective judgments to infer intrinsic motivation); inadequate experimental…

Searching for Unresolved Binary Brown Dwarfs

NASA Astrophysics Data System (ADS)

Albretsen, Jacob; Stephens, Denise

2007-10-01

There are currently L and T brown dwarfs (BDs) with errors in their classification of +/- 1 to 2 spectra types. Metallicity and gravitational differences have accounted for some of these discrepancies, and recent studies have shown unresolved binary BDs may offer some explanation as well. However limitations in technology and resources often make it difficult to clearly resolve an object that may be binary in nature. Stephens and Noll (2006) identified statistically strong binary source candidates from Hubble Space Telescope (HST) images of Trans-Neptunian Objects (TNOs) that were apparently unresolved using model point-spread functions for single and binary sources. The HST archive contains numerous observations of BDs using the Near Infrared Camera and Multi-Object Spectrometer (NICMOS) that have never been rigorously analyzed for binary properties. Using methods developed by Stephens and Noll (2006), BD observations from the HST data archive are being analyzed for possible unresolved binaries. Preliminary results will be presented. This technique will identify potential candidates for future observations to determine orbital information.

Classification of spatially unresolved objects

NASA Technical Reports Server (NTRS)

Nalepka, R. F.; Horwitz, H. M.; Hyde, P. D.; Morgenstern, J. P.

1972-01-01

A proportion estimation technique for classification of multispectral scanner images is reported that uses data point averaging to extract and compute estimated proportions for a single average data point to classify spatial unresolved areas. Example extraction calculations of spectral signatures for bare soil, weeds, alfalfa, and barley prove quite accurate.

Qualitative and quantitative assessment of Unresolved Complex Mixture in PM2.5 of Bakersfield, CA.

EPA Science Inventory

The 2010 CalNex (California Nexus) field experiment offered an opportunity for detailed characterization of atmospheric particulate carbon composition and sources in Bakersfield, CA. In the current study, the authors describe and employ a new protocol for reporting unresolved com...

The determination of surface albedo from meteorological satellites

NASA Technical Reports Server (NTRS)

Johnson, W. T.

1977-01-01

A surface albedo was determined from visible data collected by the NOAA-4 polar orbiting meteorological satellite. To filter out the major cause of atmospheric reflectivity, namely clouds, techniques were developed and applied to the data resulting in a map of global surface albedo. Neglecting spurious surface albedos for regions with persistent cloud cover, sun glint effects, insufficient reflected light and, at this time, some unresolved influences, the surface albedos retrieved from satellite data closely matched those of a global surface albedo map produced from surface and aircraft measurements and from characteristic albedos for land type and land use.

Interparental conflict, children’s security with parents, and long-term risk of internalizing problems: A longitudinal study from ages 2 to 10

PubMed Central

Brock, Rebecca L.; Kochanska, Grazyna

2015-01-01

Although the negative impact of marital conflict on children has been amply documented, few studies have examined the process of risk in a long-term, longitudinal design. We examined parent–child attachment security as a mechanism that may account for the impact of interparental conflict on children’s long-term risk of internalizing problems. Sixty-two community mothers, fathers, and children were followed from ages 2 to 10. Parents reported on their conflicts when their children were 2. Trained observers produced parent–child attachment security scores (Attachment Q-Set, Waters, 1987), based on lengthy naturalistic observations of the child with each parent. Parents rated children’s internalizing problems at age 10. A conditional process model and bootstrap approach were implemented to examine conditional indirect effects of conflict on child internalizing problems through attachment security for girls versus boys. Maladaptive marital conflict (destructive strategies, severity of arguments) increased internalizing problems 8 years later due to the undermined security for girls, whereas negative emotional aftermath of conflict (unresolved, lingering tension) increased internalizing problems for both boys and girls. The emotional aftermath of conflict is often overlooked, yet it appears to be a key dimension influencing emotional security in the family system, with significant consequences for children’s development. PMID:25797703

Interparental conflict, children's security with parents, and long-term risk of internalizing problems: A longitudinal study from ages 2 to 10.

PubMed

Brock, Rebecca L; Kochanska, Grazyna

2016-02-01

Although the negative impact of marital conflict on children has been amply documented, few studies have examined the process of risk in a long-term, longitudinal design. We examined parent-child attachment security as a mechanism that may account for the impact of interparental conflict on children's long-term risk of internalizing problems. Sixty-two community mothers, fathers, and children were followed from ages 2 to 10. Parents reported on their conflicts when their children were 2. Trained observers produced parent-child attachment security scores (Attachment Q-Set, Waters, 1987), based on lengthy naturalistic observations of the child with each parent. Parents rated children's internalizing problems at age 10. A conditional process model and bootstrap approach were implemented to examine conditional indirect effects of conflict on child internalizing problems through attachment security for girls versus boys. Maladaptive marital conflict (destructive strategies, severity of arguments) increased internalizing problems 8 years later due to the undermined security for girls, whereas negative emotional aftermath of conflict (unresolved, lingering tension) increased internalizing problems for both boys and girls. The emotional aftermath of conflict is often overlooked, yet it appears to be a key dimension influencing emotional security in the family system, with significant consequences for children's development.

High-rise housing in the city of Samara: the first steps on the path to sustainable development

NASA Astrophysics Data System (ADS)

Vavilova, Tatiana Ya.; Makeeva, Elena Yu.

2018-03-01

This paper outlines theoretical background of high-rise housing and discusses its design experience. It particularly focuses on environmental, social and economic aspects which are among crucial sustainable development issues. The authors dwell upon the implementation of innovative solutions that meet principles and goals of sustainable development and take construction objects built in Samara (which is one of the largest metropolises in Russia) as an example. The research also investigates the quality of project designs and reveals techniques corresponding to the "green standards". It considers the issues of practicing high-rise building construction in specific urban conditions and identifies unresolved architectural problems.

Status and future of lunar geoscience

NASA Technical Reports Server (NTRS)

1986-01-01

The Moon is of special interest among the many and diverse bodies of the solar system because it serves as a scientific baseline for understanding the terrestrial planets, its origin is closely tied to the early history of the Earth, and its proximity permits a variety of space applications such as mining and establishment of bases and colonies. Data acquisition and analysis have enabled advances to be made and the remaining questions in many fields of lunar geoscience to be identified. The status and unresolved problems of lunar science are discussed. Immediate needs, new unmanned missions, and a return to the Moon (a lunar base) are examined.

Aeroelastic Tailoring of Transport Wings Including Transonic Flutter Constraints

NASA Technical Reports Server (NTRS)

Stanford, Bret K.; Wieseman, Carol D.; Jutte, Christine V.

2015-01-01

Several minimum-mass optimization problems are solved to evaluate the effectiveness of a variety of novel tailoring schemes for subsonic transport wings. Aeroelastic stress and panel buckling constraints are imposed across several trimmed static maneuver loads, in addition to a transonic flutter margin constraint, captured with aerodynamic influence coefficient-based tools. Tailoring with metallic thickness variations, functionally graded materials, balanced or unbalanced composite laminates, curvilinear tow steering, and distributed trailing edge control effectors are all found to provide reductions in structural wing mass with varying degrees of success. The question as to whether this wing mass reduction will offset the increased manufacturing cost is left unresolved for each case.

The dancing plague: a public health conundrum.

PubMed

Donaldson, L J; Cavanagh, J; Rankin, J

1997-07-01

The phenomenon of mass, frenzied dancing affected large populations in various parts of Europe from the thirteenth century and lasted, on and off, for three centuries. The exact aetiology of the Dancing Plague (or Dancing Mania) is still unclear. Retrospective historical review of this public health problem reveals claims for causative factors including demonic possession, epilepsy, the bite of a tarantula, ergot poisoning and social adversity. It seems unlikely that Dancing Mania resulted from a single cause but rather resulted from multiple factors combining with a predisposing cultural background and triggered by adverse social circumstances. Dancing Mania remains one of the unresolved mysteries of public health.

Single realization stochastic FDTD for weak scattering waves in biological random media.

PubMed

Tan, Tengmeng; Taflove, Allen; Backman, Vadim

2013-02-01

This paper introduces an iterative scheme to overcome the unresolved issues presented in S-FDTD (stochastic finite-difference time-domain) for obtaining ensemble average field values recently reported by Smith and Furse in an attempt to replace the brute force multiple-realization also known as Monte-Carlo approach with a single-realization scheme. Our formulation is particularly useful for studying light interactions with biological cells and tissues having sub-wavelength scale features. Numerical results demonstrate that such a small scale variation can be effectively modeled with a random medium problem which when simulated with the proposed S-FDTD indeed produces a very accurate result.

Single realization stochastic FDTD for weak scattering waves in biological random media

PubMed Central

Tan, Tengmeng; Taflove, Allen; Backman, Vadim

2015-01-01

This paper introduces an iterative scheme to overcome the unresolved issues presented in S-FDTD (stochastic finite-difference time-domain) for obtaining ensemble average field values recently reported by Smith and Furse in an attempt to replace the brute force multiple-realization also known as Monte-Carlo approach with a single-realization scheme. Our formulation is particularly useful for studying light interactions with biological cells and tissues having sub-wavelength scale features. Numerical results demonstrate that such a small scale variation can be effectively modeled with a random medium problem which when simulated with the proposed S-FDTD indeed produces a very accurate result. PMID:27158153

Unresolved Childhood Sexual Abuse: Are Older Adults Affected?

ERIC Educational Resources Information Center

Allers, Christopher T.; And Others

1992-01-01

Presents case studies and discussions regarding 3 observed characteristics of unresolved childhood sexual abuse in adult survivors over 65 years of age. Specifically, chronic depression, elder abuse, and misdiagnosis of residual abuse trauma as dementia or mental illness are compared to parallel issues identified by researchers working with…

29 CFR 1691.10 - Agency enforcement of unresolved complaints.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Section 1691.10 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION... ASSISTANCE § 1691.10 Agency enforcement of unresolved complaints. (a) Upon EEOC's transmittal of a reasonable cause determination and notice of failure of conciliation under § 1691.9(b)(2) of this regulation, the...

29 CFR 1691.10 - Agency enforcement of unresolved complaints.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Section 1691.10 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION... ASSISTANCE § 1691.10 Agency enforcement of unresolved complaints. (a) Upon EEOC's transmittal of a reasonable cause determination and notice of failure of conciliation under § 1691.9(b)(2) of this regulation, the...

29 CFR 1691.10 - Agency enforcement of unresolved complaints.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Section 1691.10 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION... ASSISTANCE § 1691.10 Agency enforcement of unresolved complaints. (a) Upon EEOC's transmittal of a reasonable cause determination and notice of failure of conciliation under § 1691.9(b)(2) of this regulation, the...

29 CFR 1691.10 - Agency enforcement of unresolved complaints.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Section 1691.10 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION... ASSISTANCE § 1691.10 Agency enforcement of unresolved complaints. (a) Upon EEOC's transmittal of a reasonable cause determination and notice of failure of conciliation under § 1691.9(b)(2) of this regulation, the...

29 CFR 1691.10 - Agency enforcement of unresolved complaints.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Section 1691.10 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION... ASSISTANCE § 1691.10 Agency enforcement of unresolved complaints. (a) Upon EEOC's transmittal of a reasonable cause determination and notice of failure of conciliation under § 1691.9(b)(2) of this regulation, the...

Cirrus microphysics and radiative transfer: Cloud field study on October 28, 1986

NASA Technical Reports Server (NTRS)

Kinne, Stefan; Ackerman, Thomas P.; Heymsfield, Andrew J.; Valero, Francisco P. J.; Sassen, Kenneth; Spinhirne, James D.

1990-01-01

The radiative properties of cirrus clouds present one of the unresolved problems in weather and climate research. Uncertainties in ice particle amount and size and, also, the general inability to model the single scattering properties of their usually complex particle shapes, prevent accurate model predictions. For an improved understanding of cirrus radiative effects, field experiments, as those of the Cirrus IFO of FIRE, are necessary. Simultaneous measurements of radiative fluxes and cirrus microphysics at multiple cirrus cloud altitudes allows the pitting of calculated versus measured vertical flux profiles; with the potential to judge current cirrus cloud modeling. Most of the problems in this study are linked to the inhomogeneity of the cloud field. Thus, only studies on more homogeneous cirrus cloud cases promises a possibility to improve current cirrus parameterizations. Still, the current inability to detect small ice particles will remain as a considerable handicap.

Challenges faced in the clinical application of artificial anal sphincters.

PubMed

Wang, Ming-hui; Zhou, Ying; Zhao, Shuang; Luo, Yun

2015-09-01

Fecal incontinence is an unresolved problem, which has a serious effect on patients, both physically and psychologically. For patients with severe symptoms, treatment with an artificial anal sphincter could be a potential option to restore continence. Currently, the Acticon Neosphincter is the only device certified by the US Food and Drug Administration. In this paper, the clinical safety and efficacy of the Acticon Neosphincter are evaluated and discussed. Furthermore, some other key studies on artificial anal sphincters are presented and summarized. In particular, this paper highlights that the crucial problem in this technology is to maintain long-term biomechanical compatibility between implants and surrounding tissues. Compatibility is affected by changes in both the morphology and mechanical properties of the tissues surrounding the implants. A new approach for enhancing the long-term biomechanical compatibility of implantable artificial sphincters is proposed based on the use of smart materials.

In Situ Airborne Instrumentation: Addressing and Solving Measurement Problems in Ice Clouds

DOE PAGES

Baumgardner, Darrel; Kok, Greg; Avallone, L.; ...

2012-02-01

A meeting of 31 international experts on in situ measurements from aircraft was held to identify unresolved questions concerning ice formation and evolution in ice clouds, assess the current state of instrumentation that can address these problems, introduce emerging technology that may overcome current measurement issues and recommend future courses of action that can improve our understanding of ice cloud microphysical processes and their impact on the environment. The meeting proceedings and outcome has been described in detail in a manuscript submitted to the Bulletin of the American Meteorological Society (BAMS) on March 24, 2011. This paper is currently undermore » review. The remainder of this summary, in the following pages, is the text of the BAMS article. A technical note that will be published by the National Center for Atmospheric Research is currently underway and is expected to be published before the end of the year.« less

Developing Media Module Proposed to Editor in Editorial Division

NASA Astrophysics Data System (ADS)

Kristanto, A.; Mustaji; Mariono, A.; Sulistiowati; Nuryati, D. W.

2018-01-01

In this era of technology in Indonesia, various publishers introduce themselves and participate in advancing the quality of education through the publication of various books as the learning sources. One of the publishers is PT. JP Press. In compiling the learning sources, we found some problems that are left unresolved by the editor. The purpose of this research is to overcome the problems that exist in PT. JP Press by developing media module. This development research uses the ADDIE model. The types of data used in this study are qualitative and quantitative data obtained based on the results of structured interviews with material experts and media experts, as well as the editorial response questionnaire provided for individual try-out and small group try-out. Therefore, it can be concluded that the medium of elementary school supplementary module proposed to the editors of PT. JP Press is valuable to be used in the teaching and learning activities.

Catching fly balls in virtual reality: a critical test of the outfielder problem.

PubMed

Fink, Philip W; Foo, Patrick S; Warren, William H

2009-12-14

How does a baseball outfielder know where to run to catch a fly ball? The "outfielder problem" remains unresolved, and its solution would provide a window into the visual control of action. It may seem obvious that human action is based on an internal model of the physical world, such that the fielder predicts the landing point based on a mental model of the ball's trajectory (TP). However, two alternative theories, Optical Acceleration Cancellation (OAC) and Linear Optical Trajectory (LOT), propose that fielders are led to the right place at the right time by coupling their movements to visual information in a continuous "online" manner. All three theories predict successful catches and similar running paths. We provide a critical test by using virtual reality to perturb the vertical motion of the ball in mid-flight. The results confirm the predictions of OAC but are at odds with LOT and TP.

Mechanism of freeze-thaw injury and recovery: A cool retrospective and warming up to new ideas.

PubMed

Arora, Rajeev

2018-05-01

Understanding cellular mechanism(s) of freeze-thaw injury (FTI) is key to the efforts for improving plant freeze-tolerance by cultural methods or molecular/genetic approaches. However, not much work has been done in the last 25+ years to advance our understanding of the nature and cellular loci of FTI. Currently, two FTI lesions are predominantly implicated: 1) structural and functional perturbations in plasma membrane; 2) ROS-induced oxidative damage. While both have stood the test of time, many questions remain unresolved and other potentially significant lesions need to be investigated. Additionally, molecular mechanism of post-thaw recovery (PTR), a critical component of frost-survival, has not been well investigated. Mechanistic understanding of repair after reversible injury could expand the options for strategies to improve frost-hardiness. In this review, without claiming to be exhaustive, I have attempted to synthesize major discoveries from last several decades on the mechanisms of FTI and the relatively little research conducted thus far on PTR mechanisms. It is followed by proposing of hypotheses for mechanism(s) for irreversible FTI or PTR involving cytosolic calcium and ROS signaling. Perspective is presented on some unresolved questions and research on new ideas to fill the knowledge gaps and advance the field. Copyright © 2018 Elsevier B.V. All rights reserved.

Data Assimilation for Applied Meteorology

NASA Astrophysics Data System (ADS)

Haupt, S. E.

2012-12-01

Although atmospheric models provide a best estimate of the future state of the atmosphere, due to sensitivity to initial condition, it is difficult to predict the precise future state. For applied problems, however, users often depend on having accurate knowledge of that future state. To improve prediction of a particular realization of an evolving flow field requires knowledge of the current state of that field and assimilation of local observations into the model. This talk will consider how dynamic assimilation can help address the concerns of users of atmospheric forecasts. First, we will look at the value of assimilation for the renewable energy industry. If the industry decision makers can have confidence in the wind and solar power forecasts, they can build their power allocations around the expected renewable resource, saving money for the ratepayers as well as reducing carbon emissions. We will assess the value to that industry of assimilating local real-time observations into the model forecasts and the value that is provided. The value of the forecasts with assimilation is important on both short (several hour) to medium range (within two days). A second application will be atmospheric transport and dispersion problems. In particular, we will look at assimilation of concentration data into a prediction model. An interesting aspect of this problem is that the dynamics are a one-way coupled system, with the fluid dynamic equations affecting the concentration equation, but not vice versa. So when the observations are of the concentration, one must infer the fluid dynamics. This one-way coupled system presents a challenge: one must first infer the changes in the flow field from observations of the contaminant, then assimilate that to recover both the advecting flow and information on the subgrid processes that provide the mixing. To accomplish such assimilation requires a robust method to match the observed contaminant field to that modeled. One approach is to separate the problem into a transport portion and a dispersion portion, representing the resolved flow and the unresolved portion. One then treats the resolved portion in a Lagrangian framework and the unresolved in an Eulerian framework to pose an optimization problem for both the transport and dispersion variables. We demonstrate how this problem can be solved by assimilating the data dynamically using a genetic algorithm variation approach (GA-Var). This technique is demonstrated on both a basic Gaussian puff problem and a Large Eddy Simulation. Finally we will show how assimilation can help bridge the gap between modeling flows at the mesoscale and flows at the fine scale that is often important for resolving flow around local features. By assimilating mesoscale model data into a computational fluid dynamics model, we can force the fine scale model to with the features at the mesoscale, providing a coupling mechanism.

NATO and Hybrid Conflict: Unresolved Issues from the Past or Unresolvable Threats of the Present?

DTIC Science & Technology

2012-09-01

order to strengthen the relationship between the UK and France, the Treaty of Dunkirk was signed in March 1947 expressing the Western European... Dunkirk Treaty was mainly a projection of European concerns about the reemergence of German aggression. The Rio Pact was more a representation of

Unresolved Loss, a Risk Factor for Offspring, Predicts Event-Related Potential Responses to Death-Related Imagery

ERIC Educational Resources Information Center

Bahm, Naomi I. Gribneau; Simon-Thomas, Emiliana R.; Main, Mary; Hesse, Erik

2017-01-01

This study investigates whether individual differences in attachment status can be detected by electrophysiological responses to loss-themed pictures. The Adult Attachment Interview (AAI) was used to identify discourse/reasoning lapses during the discussion of loss experiences via death that place speakers in the Unresolved/disorganized AAI…

Development of an Art Psychotherapy Model for the Prevention and Treatment of Unresolved Grief during Midlife.

ERIC Educational Resources Information Center

Turetsky, Cheryl J.; Hays, Ronald E.

2003-01-01

Presents an integrated model as an appropriate intervention to enable mourning and creativity and thus help in the prevention and treatment of unresolved grief in midlife. Two examples of this model in art-psychotherapy group treatment are provided. (Contains 53 references, 1 table, and 2 figures.) (GCP)

Unresolved Attachment, PTSD, and Dissociation in Women with Childhood Abuse Histories

ERIC Educational Resources Information Center

Stovall-McClough, K. Chase; Cloitre, Marylene

2006-01-01

The primary objective of this study was to examine unresolved trauma as assessed by the Adult Attachment Interview and current psychiatric symptoms, focusing on posttraumatic stress disorder (PTSD) and dissociation, in a group of adult female childhood abuse survivors. The authors examined psychiatric symptoms and attachment representations in a…

The Relationship between Psychological Well-Being and Perceived Wellness in Graduate-Level Counseling Students

ERIC Educational Resources Information Center

Harris, Michel; Martin, Magy; Martin, Don

2013-01-01

Research has established that individuals who provide personal therapy to others should have stable personal and professional lives, and possess a keen and accurate perception of wellness. Unfortunately, sometimes students pursuing careers in counseling and psychotherapy have unresolved psychological issues that, if unresolved, could later affect…

Observation of Unresolved Features in the Microwave Sky

NASA Astrophysics Data System (ADS)

Kowitt, M. S.; Cheng, E. S.; Cottingham, D. A.; Fixsen, D. J.; Silverberg, R. F.; Inman, C. A.; Meyer, S. S.; Puchalla, J. L.; Ruhl, J. E.; Page, L. A.

1994-12-01

We report on the detection of unresolved features in broadband observations from 5.6 to 22.5 cm(-1) with a 0\\fdg5 beam by the Medium Scale Anisotropy Measurement (Cheng et al. 1994, ApJ, 422, L37). Spectra for the features will be presented, along with a discussion of their possible origin.

47 CFR 73.810 - Third adjacent channel complaint and license modification procedure.

Code of Federal Regulations, 2012 CFR

2012-10-01

... LPFM station's remedial efforts. (d) In the event that the number of unresolved complaints plus the... interference is traceable to the LPFM station. (e) If the number of unresolved and disputed complaints exceeds...) BROADCAST RADIO SERVICES RADIO BROADCAST SERVICES Low Power FM Broadcast Stations (LPFM) § 73.810 Third...

47 CFR 73.810 - Third adjacent channel complaint and license modification procedure.

Code of Federal Regulations, 2010 CFR

2010-10-01

... LPFM station's remedial efforts. (d) In the event that the number of unresolved complaints plus the... interference is traceable to the LPFM station. (e) If the number of unresolved and disputed complaints exceeds...) BROADCAST RADIO SERVICES RADIO BROADCAST SERVICES Low Power FM Broadcast Stations (LPFM) § 73.810 Third...

47 CFR 73.810 - Third adjacent channel complaint and license modification procedure.

Code of Federal Regulations, 2011 CFR

2011-10-01

... LPFM station's remedial efforts. (d) In the event that the number of unresolved complaints plus the... interference is traceable to the LPFM station. (e) If the number of unresolved and disputed complaints exceeds...) BROADCAST RADIO SERVICES RADIO BROADCAST SERVICES Low Power FM Broadcast Stations (LPFM) § 73.810 Third...

New Theoretical Estimates of the Contribution of Unresolved Star-Forming Galaxies to the Extragalactic Gamma-Ray Background (EGB) as Measured by EGRET and the Fermi-LAT

NASA Technical Reports Server (NTRS)

Venters, Tonia M.

2011-01-01

We present new theoretical estimates of the contribution of unresolved star-forming galaxies to the extragalactic gamma-ray background (EGB) as measured by EGRET and the Fermi-LAT. We employ several methods for determining the star-forming galaxy contribution the the EGB, including a method positing a correlation between the gamma-ray luminosity of a galaxy and its rate of star formation as calculated from the total infrared luminosity, and a method that makes use of a model of the evolution of the galaxy gas mass with cosmic time. We find that depending on the model, unresolved star-forming galaxies could contribute significantly to the EGB as measured by the Fermi-LAT at energies between approx. 300 MeV and approx. few GeV. However, the overall spectrum of unresolved star-forming galaxies can explain neither the EGRET EGB spectrum at energies between 50 and 200 MeV nor the Fermi-LAT EGB spectrum at energies above approx. few GeV.

Status of native fishes in the western United States and issues for fire and fuels management

USGS Publications Warehouse

Rieman, B.; Lee, D.; Burns, D.; Gresswell, Robert E.; Young, M.; Stowell, R.; Rinne, J.; Howell, P.

2003-01-01

Conservation of native fishes and changing patterns in wildfire and fuels are defining challenges for managers of forested landscapes in the western United States. Many species and populations of native fishes have declined in recorded history and some now occur as isolated remnants of what once were larger more complex systems. Land management activities have been viewed as one cause of this problem. Fires also can have substantial effects on streams and riparian systems and may threaten the persistence of some populations of fish, particularly those that are small and isolated. Despite that, major new efforts to actively manage fires and fuels in forests throughout the region may be perceived as a threat rather than a benefit to conservation of native fishes and their habitats. The management of terrestrial and aquatic resources has often been contentious, divided among a variety of agencies with different goals and mandates. Management of forests, for example, has generally been viewed as an impact on aquatic systems. Implementation of the management-regulatory process has reinforced a uniform approach to mitigate the threats to aquatic species and habitats that may be influenced by management activities. The problems and opportunities, however, are not the same across the landscapes of interest. Attempts to streamline the regulatory process often search for generalized solutions that may oversimplify the complexity of natural systems. Significant questions regarding the influence of fire on aquatic ecosystems, changing fire regimes, and the effects of fire-related management remain unresolved and contribute to the uncertainty. We argue that management of forests and fishes can be viewed as part of the same problem, that of conservation and restoration of the natural processes that create diverse and productive ecosystems. We suggest that progress toward more integrated management of forests and native fishes will require at least three steps: (1) better integration and development of a common conceptual foundation and ecological goals; (2) attention to landscape and ecological context; and (3) recognition of uncertainty.

Combining FMEA with DEMATEL models to solve production process problems

PubMed Central

Tsai, Sang-Bing; Zhou, Jie; Gao, Yang; Wang, Jiangtao; Li, Guodong; Zheng, Yuxiang; Ren, Peng; Xu, Wei

2017-01-01

Failure mode and effects analysis (FMEA) is an analysis tool for identifying and preventing flaws or defects in products during the design and process planning stage, preventing the repeated occurrence of problems, reducing the effects of these problems, enhancing product quality and reliability, saving costs, and improving competitiveness. However, FMEA can only analyze one influence factor according to its priority, rendering this method ineffective for systems containing multiple FMs whose effects are simultaneous or interact with one another. Accordingly, when FMEA fails to identify the influence factors and the factors being influenced, the most crucial problems may be placed in lower priority or remain unresolved. Decision-Making Trial and Evaluation Laboratory (DEMATEL) facilitates the determination of cause and effect factors; by identifying the causal factors that should be prioritized, prompt and effective solutions to core problems can be derived, thereby enhancing performance. Using the photovoltaic cell manufacturing industry in China as the research target, the present study combined FMEA with DEMATEL to amend the flaws of FMEA and enhance its effectiveness. First, FMEA was used to identify items requiring improvement. Then, DEMATEL was employed to examine the interactive effects and causal relationships of these items. Finally, the solutions to the problems were prioritized. The proposed method effectively combined the advantages of FMEA and DEMATEL to facilitate the identification of core problems and prioritization of solutions in the Chinese photovoltaic cell industry. PMID:28837663

Combining FMEA with DEMATEL models to solve production process problems.

PubMed

Tsai, Sang-Bing; Zhou, Jie; Gao, Yang; Wang, Jiangtao; Li, Guodong; Zheng, Yuxiang; Ren, Peng; Xu, Wei

2017-01-01

Failure mode and effects analysis (FMEA) is an analysis tool for identifying and preventing flaws or defects in products during the design and process planning stage, preventing the repeated occurrence of problems, reducing the effects of these problems, enhancing product quality and reliability, saving costs, and improving competitiveness. However, FMEA can only analyze one influence factor according to its priority, rendering this method ineffective for systems containing multiple FMs whose effects are simultaneous or interact with one another. Accordingly, when FMEA fails to identify the influence factors and the factors being influenced, the most crucial problems may be placed in lower priority or remain unresolved. Decision-Making Trial and Evaluation Laboratory (DEMATEL) facilitates the determination of cause and effect factors; by identifying the causal factors that should be prioritized, prompt and effective solutions to core problems can be derived, thereby enhancing performance. Using the photovoltaic cell manufacturing industry in China as the research target, the present study combined FMEA with DEMATEL to amend the flaws of FMEA and enhance its effectiveness. First, FMEA was used to identify items requiring improvement. Then, DEMATEL was employed to examine the interactive effects and causal relationships of these items. Finally, the solutions to the problems were prioritized. The proposed method effectively combined the advantages of FMEA and DEMATEL to facilitate the identification of core problems and prioritization of solutions in the Chinese photovoltaic cell industry.

Essential problems in the interpretation of epidemiologic evidence for an association between mobile phone use and brain tumours

NASA Astrophysics Data System (ADS)

Kundi, Michael

2010-11-01

Due to the close proximity of a mobile phone to the head when placing a call, concerns have been raised that exposure from microwaves during mobile phone use may exert adverse health effects and, in particular, may increase the risk of brain tumours. In response to these concerns epidemiological studies have been conducted, most applying the case-control design. While epidemiology can provide decisive evidence for an association between an exposure and a disease fundamental problems arise if exposure is short compared to the natural history of the disease. For brain tumours latencies of decades have been implicated making special considerations about potential effects of exposures necessary that commence during an already growing tumour. It is shown that measures of disease risk like odds ratios and relative risks can under such circumstances not be interpreted as indicators of a long term effect on incidences in the exposed population. Besides this problem, the issues of a suitable exposure metric and the selection of endpoints are unresolved. It is shown that the solution of these problems affords knowledge about the mechanism of action by which exposure increases the risk of manifest disease.

Chemistry on the mesoscale: Modeling and measurement issues

NASA Technical Reports Server (NTRS)

Thompson, Anne; Pleim, John; Walcek, Christopher; Ching, Jason; Binkowski, Frank; Tao, Wei-Kuo; Dickerson, Russell; Pickering, Kenneth

1993-01-01

The topics covered include the following: Regional Acid Deposition Model (RADM) -- a coupled chemistry/mesoscale model; convection in RADM; unresolved issues for mesoscale modeling with chemistry -- nonprecipitating clouds; unresolved issues for mesoscale modeling with chemistry -- aerosols; tracer studies with Goddard Cumulus Ensemble Model (GCEM); field observations of trace gas transport in convection; and photochemical consequences of convection.

A Comparison of Unresolved Versus Resolved Status and Its Relationship to Behaviour in Maltreated Adolescents

ERIC Educational Resources Information Center

Webster, Linda; Hackett, Rachelle Kisst

2007-01-01

This exploratory investigation sought both to gain a better understanding of the mental representations of attachment in high-risk, maltreated adolescents and to explain how, if at all, unresolved attachment representations are related to behavioural maladjustment. Parent ratings, self-report ratings and attachment state of mind were obtained from…

NATURE OF UNRESOLVED COMPLEX MIXTURE IN SIZE-DISTRIBUTED EMISSIONS FROM RESIDENTIAL WOOD COMBUSTION AS MEASURED BY THERMAL DESORPTION-GAS CHROMATOGRAPHY-MASS SPECTROMETRY

EPA Science Inventory

In this study, the unresolved complex mixture (UCM) in size resolved fine aerosol emissions from residential wood combustion (RWC) is examined. The aerosols are sorted by size in an electrical low-pressure impactor (ELPI) and subsequently analyzed by thermal desorbtion/gas chroma...

National Technology Standards for K-12 Schools: A Case Study of Unresolved Issues in Public Relations

ERIC Educational Resources Information Center

Mullen, Carol A.; Kealy, William A.; Sullivan, Ashley

2004-01-01

This article addresses an important need--the dissemination of information relating to technology as a public relations tool--and the associated exigency for administrator and teacher technology training. Specifically, we identify the increased expectations for the performance of school leaders and teachers, as well as unresolved issues in public…

A subtraction scheme for computing QCD jet cross sections at NNLO: integrating the iterated singly-unresolved subtraction terms

NASA Astrophysics Data System (ADS)

Bolzoni, Paolo; Somogyi, Gábor; Trócsányi, Zoltán

2011-01-01

We perform the integration of all iterated singly-unresolved subtraction terms, as defined in ref. [1], over the two-particle factorized phase space. We also sum over the unresolved parton flavours. The final result can be written as a convolution (in colour space) of the Born cross section and an insertion operator. We spell out the insertion operator in terms of 24 basic integrals that are defined explicitly. We compute the coefficients of the Laurent expansion of these integrals in two different ways, with the method of Mellin-Barnes representations and sector decomposition. Finally, we present the Laurent-expansion of the full insertion operator for the specific examples of electron-positron annihilation into two and three jets.

A review of promoting access to medicines in China - problems and recommendations.

PubMed

Sun, Jing; Hu, Cecile Jia; Stuntz, Mark; Hogerzeil, Hans; Liu, Yuanli

2018-02-20

Despite recent reforms, distorting funding mechanisms and over-prescribing still maintain severe financial barriers to medicines access in China. Complicated and interrelated problems in the pharmaceutical sector require a common framework to be resolved as fragmented solutions do not work. We present a preliminary assessment of the impact of the national healthcare reforms on access to medicines, and propose policy recommendations for promoting universal access to medicines in China. Drawing on multiple sources of information, including a review of published literatures and official national data, field investigations in six provinces and interviews with key opinion leaders, this paper presents a preliminary assessment of the impact of the national healthcare reforms on access to medicines, and proposes policy recommendations for promoting universal access to medicines in China. Public expenditure on medicines has been strictly controlled since the national healthcare reforms of 2009. Yet total pharmaceutical expenditure (TPE) and total health expenditure growth rates continuously outpaced the growth of gross domestic product (GDP). With 2.4% of GDP, TPE now exceeds that of most high income countries. The distorted provider and consumer incentives in the Chinese health system have not fundamentally changed. Price-setting and reimbursement mechanisms do not promote cost-effective use of medicines. Inappropriate price controls and perverse financial incentives are the un-resolved root causes of preference of originator brands for some major diseases and shortages of low-cost and low-consumption medicines. In addition, access to expensive life-saving medicines is yet systematically addressed. The complicated and interdependent problems interact in a way that leads to significant system problems in China, which create dual challenges that both the developing country and the developed countries are facing. To further promote access to medicines, China should speed up the re-assessment of the quality and efficacy of domestically produced generic medicines; coordinate various reforms of price determination, insurance payments, and procurement policies; address medicine shortages through comprehensive policies and legislation; establish specific mechanisms to achieve sustainable equitable access to expensive essential medicines with health technology assessment as a tool to ensure that policy and priority setting are created in a coherent and evidence-based way.

Stochastic Ocean Eddy Perturbations in a Coupled General Circulation Model.

NASA Astrophysics Data System (ADS)

Howe, N.; Williams, P. D.; Gregory, J. M.; Smith, R. S.

2014-12-01

High-resolution ocean models, which are eddy permitting and resolving, require large computing resources to produce centuries worth of data. Also, some previous studies have suggested that increasing resolution does not necessarily solve the problem of unresolved scales, because it simply introduces a new set of unresolved scales. Applying stochastic parameterisations to ocean models is one solution that is expected to improve the representation of small-scale (eddy) effects without increasing run-time. Stochastic parameterisation has been shown to have an impact in atmosphere-only models and idealised ocean models, but has not previously been studied in ocean general circulation models. Here we apply simple stochastic perturbations to the ocean temperature and salinity tendencies in the low-resolution coupled climate model, FAMOUS. The stochastic perturbations are implemented according to T(t) = T(t-1) + (ΔT(t) + ξ(t)), where T is temperature or salinity, ΔT is the corresponding deterministic increment in one time step, and ξ(t) is Gaussian noise. We use high-resolution HiGEM data coarse-grained to the FAMOUS grid to provide information about the magnitude and spatio-temporal correlation structure of the noise to be added to the lower resolution model. Here we present results of adding white and red noise, showing the impacts of an additive stochastic perturbation on mean climate state and variability in an AOGCM.

The ethics of human volunteer studies involving experimental exposure to pesticides: unanswered dilemmas

PubMed Central

2010-01-01

The controversy about the use of data from human volunteer studies involving experimental exposure to pesticides as part of regulatory risk assessment has been widely discussed, but the complex and interrelated scientific and ethical issues remain largely unresolved. This discussion paper, generated by authors who comprised a workgroup of the ICOH Scientific Committee on Rural Health, reviews the use of human experimental studies in regulatory risk assessment for pesticides with a view to advancing the debate as to when, if ever, such studies might be ethically justifiable. The discussion is based on three elements: (a) a review of discussion papers on the topic of human testing of pesticides and the positions adopted by regulatory agencies in developed countries; (b) an analysis of published and unpublished studies involving human testing with pesticides, both in the peer-reviewed literature and in the JMPR database; and (c) application of an ethical analysis to the problem. The paper identifies areas of agreement which include general principles that may provide a starting point on which to base criteria for judgements as to the ethical acceptability of such studies. However, the paper also highlights ongoing unresolved differences of opinion inherent in ethical analysis of contentious issues, which we propose should form a starting point for further debate and the development of guidelines to achieve better resolution of this matter. PMID:20718963

Explicit Global Simulation of Gravity Waves up to the Lower Thermosphere

NASA Astrophysics Data System (ADS)

Becker, E.

2016-12-01

At least for short-term simulations, middle atmosphere general circulation models (GCMs) can be run with sufficiently high resolution in order to describe a good part of the gravity wave spectrum explicitly. Nevertheless, the parameterization of unresolved dynamical scales remains an issue, especially when the scales of parameterized gravity waves (GWs) and resolved GWs become comparable. In addition, turbulent diffusion must always be parameterized along with other subgrid-scale dynamics. A practical solution to the combined closure problem for GWs and turbulent diffusion is to dispense with a parameterization of GWs, apply a high spatial resolution, and to represent the unresolved scales by a macro-turbulent diffusion scheme that gives rise to wave damping in a self-consistent fashion. This is the approach of a few GCMs that extend from the surface to the lower thermosphere and simulate a realistic GW drag and summer-to-winter-pole residual circulation in the upper mesosphere. In this study we describe a new version of the Kuehlungsborn Mechanistic general Circulation Model (KMCM), which includes explicit (though idealized) computations of radiative transfer and the tropospheric moisture cycle. Particular emphasis is spent on 1) the turbulent diffusion scheme, 2) the attenuation of resolved GWs at critical levels, 3) the generation of GWs in the middle atmosphere from body forces, and 4) GW-tidal interactions (including the energy deposition of GWs and tides).

Assessing 1D Atmospheric Solar Radiative Transfer Models: Interpretation and Handling of Unresolved Clouds.

NASA Astrophysics Data System (ADS)

Barker, H. W.; Stephens, G. L.; Partain, P. T.; Bergman, J. W.; Bonnel, B.; Campana, K.; Clothiaux, E. E.; Clough, S.; Cusack, S.; Delamere, J.; Edwards, J.; Evans, K. F.; Fouquart, Y.; Freidenreich, S.; Galin, V.; Hou, Y.; Kato, S.; Li, J.;  Mlawer, E.;  Morcrette, J.-J.;  O'Hirok, W.;  Räisänen, P.;  Ramaswamy, V.;  Ritter, B.;  Rozanov, E.;  Schlesinger, M.;  Shibata, K.;  Sporyshev, P.;  Sun, Z.;  Wendisch, M.;  Wood, N.;  Yang, F.

2003-08-01

The primary purpose of this study is to assess the performance of 1D solar radiative transfer codes that are used currently both for research and in weather and climate models. Emphasis is on interpretation and handling of unresolved clouds. Answers are sought to the following questions: (i) How well do 1D solar codes interpret and handle columns of information pertaining to partly cloudy atmospheres? (ii) Regardless of the adequacy of their assumptions about unresolved clouds, do 1D solar codes perform as intended?One clear-sky and two plane-parallel, homogeneous (PPH) overcast cloud cases serve to elucidate 1D model differences due to varying treatments of gaseous transmittances, cloud optical properties, and basic radiative transfer. The remaining four cases involve 3D distributions of cloud water and water vapor as simulated by cloud-resolving models. Results for 25 1D codes, which included two line-by-line (LBL) models (clear and overcast only) and four 3D Monte Carlo (MC) photon transport algorithms, were submitted by 22 groups. Benchmark, domain-averaged irradiance profiles were computed by the MC codes. For the clear and overcast cases, all MC estimates of top-of-atmosphere albedo, atmospheric absorptance, and surface absorptance agree with one of the LBL codes to within ±2%. Most 1D codes underestimate atmospheric absorptance by typically 15-25 W m-2 at overhead sun for the standard tropical atmosphere regardless of clouds.Depending on assumptions about unresolved clouds, the 1D codes were partitioned into four genres: (i) horizontal variability, (ii) exact overlap of PPH clouds, (iii) maximum/random overlap of PPH clouds, and (iv) random overlap of PPH clouds. A single MC code was used to establish conditional benchmarks applicable to each genre, and all MC codes were used to establish the full 3D benchmarks. There is a tendency for 1D codes to cluster near their respective conditional benchmarks, though intragenre variances typically exceed those for the clear and overcast cases. The majority of 1D codes fall into the extreme category of maximum/random overlap of PPH clouds and thus generally disagree with full 3D benchmark values. Given the fairly limited scope of these tests and the inability of any one code to perform extremely well for all cases begs the question that a paradigm shift is due for modeling 1D solar fluxes for cloudy atmospheres.

Large-scale outflows in luminous QSOs revisited. The impact of beam smearing on AGN feedback efficiencies

NASA Astrophysics Data System (ADS)

Husemann, B.; Scharwächter, J.; Bennert, V. N.; Mainieri, V.; Woo, J.-H.; Kakkad, D.

2016-10-01

Context. Feedback from active galactic nuclei (AGN) is thought to play an important role in quenching star formation in galaxies. However, the efficiency with which AGN dissipate their radiative energy into the ambient medium remains strongly debated. Aims: Enormous observational efforts have been made to constrain the energetics of AGN feedback by mapping the kinematics of the ionized gas on kpc scale. We study how the observed kinematics and inferred energetics are affected by beam smearing of a bright unresolved narrow-line region (NLR) due to seeing. Methods: We re-analyse optical integral-field spectroscopy of a sample of twelve luminous unobscured quasi-stellar objects (QSOs) (0.4

From experimental systems to evolutionary biology: an impossible journey?

PubMed

Morange, Michel

2013-01-01

The historical approach to the sciences has undergone a sea change during recent decades. Maybe the major contribution of Hans-Jörg Rheinberger to this movement was his demonstration of the importance of experimental systems, and of their transformations, in the development of the sciences. To describe these transformations, Hans-Jörg borrows metaphors from evolutionary biology. I want to argue that evolutionary biologists can find in these recent historical studies plenty of models and concepts to address unresolved issues in their discipline. At a time when transdisciplinarity is highly praised, it is useful to provide a precise description of the obstacles that have so far prevented this exchange.

Dissecting the Components of Long-Term Potentiation

PubMed Central

Blundon, Jay A.; Zakharenko, Stanislav S.

2009-01-01

The formation of memories relies on plastic changes at synapses between neurons. Although the mechanisms of synaptic plasticity have been studied extensively over several decades, many aspects of this process remain controversial. The cellular locus of expression of long-term potentiation (LTP), a major form of synaptic plasticity, is one of the most important unresolved phenomena. In this article, we summarize some recent advances in this area made possible by the development of new imaging tools. These studies have demonstrated that LTP is compound in nature and consists of both presynaptic and postsynaptic components. We also review some features of presynaptic and postsynaptic changes during compound LTP. PMID:18940785

Predicting the formation and the dispersion of toxic combustion products from the fires of dangerous substances

NASA Astrophysics Data System (ADS)

Nevrlý, V.; Bitala, P.; Danihelka, P.; Dobeš, P.; Dlabka, J.; Hejzlar, T.; Baudišová, B.; Míček, D.; Zelinger, Z.

2012-04-01

Natural events, such as wildfires, lightning or earthquakes represent a frequent trigger of industrial fires involving dangerous substances. Dispersion of smoke plume from such fires and the effects of toxic combustion products are one of the reference scenarios expected in the framework of major accident prevention. Nowadays, tools for impact assessment of these events are rather missing. Detailed knowledge of burning material composition, atmospheric conditions, and other factors are required in order to describe quantitatively the source term of toxic fire products and to evaluate the parameters of smoke plume. Nevertheless, an assessment of toxic emissions from large scale fires involves a high degree of uncertainty, because of the complex character of physical and chemical processes in the harsh environment of uncontrolled flame. Among the others, soot particle formation can be mentioned as still being one of the unresolved problems in combustion chemistry, as well as decomposition pathways of chemical substances. Therefore, simplified approach for estimating the emission factors from outdoor fires of dangerous chemicals, utilizable for major accident prevention and preparedness, was developed and the case study illustrating the application of the proposed method was performed. ALOFT-FT software tool based on large eddy simulation of buoyant fire plumes was employed for predicting the local toxic contamination in the down-wind vicinity of the fire. The database of model input parameters can be effectively modified enabling the simulation of the smoke plume from pool fires or jet fires of arbitrary flammable (or combustible) gas, liquid or solid. This work was supported by the Ministry of Education, Youth and Sports of the Czech Republic via the project LD11012 (in the frame of the COST CM0901 Action) and the Ministry of Environment of the Czech Republic (project no. SPII 1a10 45/70).

Guidelines for the management of neovascular age-related macular degeneration by the European Society of Retina Specialists (EURETINA)

PubMed Central

Schmidt-Erfurth, Ursula; Chong, Victor; Loewenstein, Anat; Larsen, Michael; Souied, Eric; Schlingemann, Reinier; Eldem, Bora; Monés, Jordi; Richard, Gisbert; Bandello, Francesco

2014-01-01

Age-related macular degeneration (AMD) is still referred to as the leading cause of severe and irreversible visual loss world-wide. The disease has a profound effect on quality of life of affected individuals and represents a major socioeconomic challenge for societies due to the exponential increase in life expectancy and environmental risks. Advances in medical research have identified vascular endothelial growth factor (VEGF) as an important pathophysiological player in neovascular AMD and intraocular inhibition of VEGF as one of the most efficient therapies in medicine. The wide introduction of anti-VEGF therapy has led to an overwhelming improvement in the prognosis of patients affected by neovascular AMD, allowing recovery and maintenance of visual function in the vast majority of patients. However, the therapeutic benefit is accompanied by significant economic investments, unresolved medicolegal debates about the use of off-label substances and overwhelming problems in large population management. The burden of disease has turned into a burden of care with a dissociation of scientific advances and real-world clinical performance. Simultaneously, ground-breaking innovations in diagnostic technologies, such as optical coherence tomography, allows unprecedented high-resolution visualisation of disease morphology and provides a promising horizon for early disease detection and efficient therapeutic follow-up. However, definite conclusions from morphologic parameters are still lacking, and valid biomarkers have yet to be identified to provide a practical base for disease management. The European Society of Retina Specialists offers expert guidance for diagnostic and therapeutic management of neovascular AMD supporting healthcare givers and doctors in providing the best state-of-the-art care to their patients. Trial registration number NCT01318941. PMID:25136079

Countertransference

PubMed Central

BOYER, L. BRYCE

1994-01-01

Freud’s ambivalently negative attitude toward countertransference discouraged systematic study until some psychoanalysts, predominantly Kleinians, began to treat patients with narcissistic neuroses. Recognizing the need to understand the unconscious and conscious contribution of the analyst to the therapeutic process, Heimann, Rosenfeld, Balint, and Racker pioneered in serious study of countertransference. Racker and Boyer found that unresolved countertransference problems contributed significantly to unfavorable responses to psychoanalysis in seriously disturbed patients. Searles, Giovacchini, Ogden, and Volkan have like-wise furthered countertransference research. Following a historical review, the author delineates his personal approach to understanding patients, especially seriously disturbed ones, in terms of the ongoing introjection of patient and analyst of each other’s projections. This approach stems from Rosenfeld’s initial propositions. PMID:22700186

For Richer, for Poorer: Money as a Topic of Marital Conflict in the Home

PubMed Central

Papp, Lauren M.; Cummings, E. Mark; Goeke-Morey, Marcie C.

2011-01-01

Guided by a family stress perspective, we examined the hypothesis that discussing money would be associated with the handling of marital conflict in the home. Analyses were based on dyadic hierarchical linear modeling of 100 husbands’ and 100 wives’ diary reports of 748 conflict instances. Contrary to findings from previous laboratory-based surveys, spouses did not rate money as the most frequent source of marital conflict in the home. However, compared to non-money issues, marital conflicts about money were more pervasive, problematic, and recurrent, and remained unresolved, despite including more attempts at problem solving. Implications for professionals who assist couples in managing their relationships and family finances are discussed. PMID:22162622

For Richer, for Poorer: Money as a Topic of Marital Conflict in the Home.

PubMed

Papp, Lauren M; Cummings, E Mark; Goeke-Morey, Marcie C

2009-02-01

Guided by a family stress perspective, we examined the hypothesis that discussing money would be associated with the handling of marital conflict in the home. Analyses were based on dyadic hierarchical linear modeling of 100 husbands' and 100 wives' diary reports of 748 conflict instances. Contrary to findings from previous laboratory-based surveys, spouses did not rate money as the most frequent source of marital conflict in the home. However, compared to non-money issues, marital conflicts about money were more pervasive, problematic, and recurrent, and remained unresolved, despite including more attempts at problem solving. Implications for professionals who assist couples in managing their relationships and family finances are discussed.

Discovery of a main-belt asteroid resembling ordinary chondrite meteorites.

PubMed

Binzel, R P; Xu, S; Bus, S J; Skrutskie, M F; Meyer, M R; Knezek, P; Barker, E S

1993-12-03

Although ordinary chondrite material dominates meteorite falls, the identification of a main-belt asteroid source has remained elusive. From a new survey of more than 80 small main-belt asteroids comes the discovery of one having a visible and near-infrared reflectance spectrum similar to L6 and LL6 ordinary chondrite meteorites. Asteroid 3628 BoZnemcová has an estimated diameter of 7 kilometers and is located in the vicinity of the 3:1 Jovian resonance, a predicted meteorite source region. Although the discovery of a spectral match may indicate the existence of ordinary chondrite material within the main asteroid belt, the paucity of such detections remains an unresolved problem.

Petrologic and Chemical Characterization of a Suite of Antarctic Diogenites

NASA Technical Reports Server (NTRS)

Mittlefehldt, D. W.; Mertzman, S. A.; Peng, Z. X.; Mertzman, K. R.

2013-01-01

The origin of diogenites, ultramafic cumulates related to eucrites, is an unresolved problem [1]. Most diogenites are orthopyroxenites, a few are harzburgites [2], and some are transitional to cumulate eucrites [1, 3]. Cumulate eucrites are gabbros formed by crystal fractionation from basaltic eucrites [4]. The consensus view is that basaltic eucrites are residual melts from global-magma-ocean crystallization on their parent asteroid [4] which is plausibly Vesta [5]. However, the petrologic and compositional characteristics of diogenites seem to preclude a magma ocean origin [1, 4]. We are doing a petrologic and chemical study of new or unusual diogenites with the ultimate goals of constraining their genesis, and the geologic evolution of Vesta.

Lagrangian numerical methods for ocean biogeochemical simulations

NASA Astrophysics Data System (ADS)

Paparella, Francesco; Popolizio, Marina

2018-05-01

We propose two closely-related Lagrangian numerical methods for the simulation of physical processes involving advection, reaction and diffusion. The methods are intended to be used in settings where the flow is nearly incompressible and the Péclet numbers are so high that resolving all the scales of motion is unfeasible. This is commonplace in ocean flows. Our methods consist in augmenting the method of characteristics, which is suitable for advection-reaction problems, with couplings among nearby particles, producing fluxes that mimic diffusion, or unresolved small-scale transport. The methods conserve mass, obey the maximum principle, and allow to tune the strength of the diffusive terms down to zero, while avoiding unwanted numerical dissipation effects.

Decoding the Nature of Emotion in the Brain.

PubMed

Kragel, Philip A; LaBar, Kevin S

2016-06-01

A central, unresolved problem in affective neuroscience is understanding how emotions are represented in nervous system activity. After prior localization approaches largely failed, researchers began applying multivariate statistical tools to reconceptualize how emotion constructs might be embedded in large-scale brain networks. Findings from pattern analyses of neuroimaging data show that affective dimensions and emotion categories are uniquely represented in the activity of distributed neural systems that span cortical and subcortical regions. Results from multiple-category decoding studies are incompatible with theories postulating that specific emotions emerge from the neural coding of valence and arousal. This 'new look' into emotion representation promises to improve and reformulate neurobiological models of affect. Copyright © 2016 Elsevier Ltd. All rights reserved.

Decoding the Nature of Emotion in the Brain

PubMed Central

Kragel, Philip A.; LaBar, Kevin S.

2016-01-01

A central, unresolved problem in affective neuroscience is understanding how emotions are represented in nervous system activity. After prior localization approaches largely failed, researchers began applying multivariate statistical tools to reconceptualize how emotion constructs might be embedded in large-scale brain networks. Findings from pattern analyses of neuroimaging data show that affective dimensions and emotion categories are uniquely represented in the activity of distributed neural systems that span cortical and subcortical regions. Results from multiple-category decoding studies are incompatible with theories postulating that specific emotions emerge from the neural coding of valence and arousal. This ‘new look’ into emotion representation promises to improve and reformulate neurobiological models of affect. PMID:27133227

The Contribution of z < or Approx. 6 Sources to the Spatial Coherence in the Unresolved Cosmic Near-Infrared and X-Ray Backgrounds

NASA Technical Reports Server (NTRS)

Helgason, K.; Cappelluti, N.; Hasinger, G.; Kashlinsky, A.; Ricotti, M.

2014-01-01

A spatial clustering signal has been established in Spitzer/IRAC measurements of the unresolved cosmic near-infrared background (CIB) out to large angular scales, approx. 1deg. This CIB signal, while significantly exceeding the contribution from the remaining known galaxies, was further found to be coherent at a highly statistically significant level with the unresolved soft cosmic X-ray background (CXB). This measurement probes the unresolved CXB to very faint source levels using deep near-IR source subtraction.We study contributions from extragalactic populations at low to intermediate redshifts to the measured positive cross-power signal of the CIB fluctuations with the CXB. We model the X-ray emission from active galactic nuclei (AGNs), normal galaxies, and hot gas residing in virialized structures, calculating their CXB contribution including their spatial coherence with all infrared emitting counterparts. We use a halo model framework to calculate the auto and cross-power spectra of the unresolved fluctuations based on the latest constraints of the halo occupation distribution and the biasing of AGNs, galaxies, and diffuse emission. At small angular scales (1), the 4.5microns versus 0.5-2 keV coherence can be explained by shot noise from galaxies and AGNs. However, at large angular scales (approx.10), we find that the net contribution from the modeled populations is only able to account for approx. 3% of the measured CIB×CXB cross-power. The discrepancy suggests that the CIB×CXB signal originates from the same unknown source population producing the CIB clustering signal out to approx. 1deg.

Integrated Analyses Resolve Conflicts over Squamate Reptile Phylogeny and Reveal Unexpected Placements for Fossil Taxa

PubMed Central

Reeder, Tod W.; Townsend, Ted M.; Mulcahy, Daniel G.; Noonan, Brice P.; Wood, Perry L.; Sites, Jack W.; Wiens, John J.

2015-01-01

Squamate reptiles (lizards and snakes) are a pivotal group whose relationships have become increasingly controversial. Squamates include >9000 species, making them the second largest group of terrestrial vertebrates. They are important medicinally and as model systems for ecological and evolutionary research. However, studies of squamate biology are hindered by uncertainty over their relationships, and some consider squamate phylogeny unresolved, given recent conflicts between molecular and morphological results. To resolve these conflicts, we expand existing morphological and molecular datasets for squamates (691 morphological characters and 46 genes, for 161 living and 49 fossil taxa, including a new set of 81 morphological characters and adding two genes from published studies) and perform integrated analyses. Our results resolve higher-level relationships as indicated by molecular analyses, and reveal hidden morphological support for the molecular hypothesis (but not vice-versa). Furthermore, we find that integrating molecular, morphological, and paleontological data leads to surprising placements for two major fossil clades (Mosasauria and Polyglyphanodontia). These results further demonstrate the importance of combining fossil and molecular information, and the potential problems of estimating the placement of fossil taxa from morphological data alone. Thus, our results caution against estimating fossil relationships without considering relevant molecular data, and against placing fossils into molecular trees (e.g. for dating analyses) without considering the possible impact of molecular data on their placement. PMID:25803280

Exercise-induced myalgia may limit the cardiovascular benefits of statins.

PubMed

Opie, Lionel H

2013-12-01

The positive health benefits of statins extend beyond the cardiovascular and include increased flow mediated dilation, decreased atrial fibrillation, modest antihypertensive effects and reduced risks of malignancies. Prominent among the statin side-effects are myalgia and muscular weakness, which may be associated with a rise in circulating creatine kinase values. In increasing severity and decreasing incidence, the statin-induced muscle related conditions are myalgia, myopathy with elevated creatine kinase (CK) levels with or without symptoms, and rhabdomyolysis. Statin use may increase CK levels without decreasing average muscle strength or exercise performance. In one large study, only about 2 % had myalgia that could be attributed to statin use. A novel current hypothesis is that statins optimize cardiac mitochondrial function but impair the vulnerable skeletal muscle by inducing different levels of reactive oxygen species (ROS) in these two sites. In an important observational study, both statins and exercise reduced the adverse outcomes of cardiovascular disease, and the effects were additive. The major unresolved problem is that either can cause muscular symptoms with elevation of blood creatine kinase levels. There is, as yet, no clearly defined outcomes based policy to deal with such symptoms from use of either statins or exercise or both. A reasonable practical approach is to assess the creatine kinase levels, and if elevated to reduce the statin dose or the intensity of exercise.

Integrated analyses resolve conflicts over squamate reptile phylogeny and reveal unexpected placements for fossil taxa.

PubMed

Reeder, Tod W; Townsend, Ted M; Mulcahy, Daniel G; Noonan, Brice P; Wood, Perry L; Sites, Jack W; Wiens, John J

2015-01-01

Squamate reptiles (lizards and snakes) are a pivotal group whose relationships have become increasingly controversial. Squamates include >9000 species, making them the second largest group of terrestrial vertebrates. They are important medicinally and as model systems for ecological and evolutionary research. However, studies of squamate biology are hindered by uncertainty over their relationships, and some consider squamate phylogeny unresolved, given recent conflicts between molecular and morphological results. To resolve these conflicts, we expand existing morphological and molecular datasets for squamates (691 morphological characters and 46 genes, for 161 living and 49 fossil taxa, including a new set of 81 morphological characters and adding two genes from published studies) and perform integrated analyses. Our results resolve higher-level relationships as indicated by molecular analyses, and reveal hidden morphological support for the molecular hypothesis (but not vice-versa). Furthermore, we find that integrating molecular, morphological, and paleontological data leads to surprising placements for two major fossil clades (Mosasauria and Polyglyphanodontia). These results further demonstrate the importance of combining fossil and molecular information, and the potential problems of estimating the placement of fossil taxa from morphological data alone. Thus, our results caution against estimating fossil relationships without considering relevant molecular data, and against placing fossils into molecular trees (e.g. for dating analyses) without considering the possible impact of molecular data on their placement.

A Chronologic Dual-Hemisphere Approach to the Last Glacial Termination from the Southern Alps of New Zealand and the Altai Mountains of Western Mongolia

NASA Astrophysics Data System (ADS)

Strand, P.; Putnam, A. E.; Schaefer, J. M.; Denton, G.; Barrell, D.; Putnam, D.; Schwartz, R.; Sambuu, O.; Radue, M. J.; Lindsay, B. J.; Stevens, J.

2017-12-01

Understanding the processes that drove the last glacial termination in the tropics and mid-latitudes is a major unresolved problem in paleoclimate. The most recent glacial to interglacial transition represents the last great global warming and the last time CO2 rose by a substantial amount before the industrial period. Determining the speed of this warming will help refine the global climate system sensitivity to CO2 and will place ongoing global warming into a paleoclimatic context. Here, we test possible drivers of the last glacial termination by comparing chronologies of mountain glaciers, which are highly sensitive to changes in atmospheric temperature, in the middle latitudes of both polar hemispheres. The dating of glacier landforms, such as moraine ridges constructed along glacier margins, affords quantitative insight into past climate conditions. We present 10Be surface-exposure chronologies and glacial geomorphologic maps of mountain glacier recession since the Last Glacial Maximum in the Southern Alps of New Zealand (44°S, 170°E) and in the Altai Mountains of western Mongolia (49°N, 88°E). On the basis of these chronologies from opposing hemispheres, we evaluate the relative roles of rising atmospheric CO2, local insolation forcing, and ocean-atmosphere reorganizations in driving the global warming that ended the last ice age.

Management of Chronic Myeloid Leukemia Patients Resistant to Tyrosine Kinase Inhibitors Treatment

PubMed Central

Wieczorek, Agnieszka; Uharek, Lutz

2015-01-01

Chronic myeloid leukemia (CML) is a myeloproliferative disorder associated with a characteristic chromosomal translocation called the Philadelphia chromosome. This oncogene is generated by the fusion of breakpoint cluster region (BCR) and Abelson leukemia virus (ABL) genes and encodes a novel fusion gene translating into a protein with constitutive tyrosine kinase activity. The discovery and introduction of tyrosine kinase inhibitors (TKIs) irreversibly changed the landscape of CML treatment, leading to dramatic improvement in long-term survival rates. The majority of patients with CML in the chronic phase have a life expectancy comparable with that of healthy age-matched individuals. Although an enormous therapeutic improvement has been accomplished, there are still some unresolved issues in the treatment of patients with CML. One of the most important problems is based on the fact that TKIs can efficiently target proliferating mature cells but do not eradicate leukemic stem cells, allowing persistence of the malignant clone. Owing to the resistance mechanisms arising during the course of the disease, treatment with most of the approved BCR-ABL1 TKIs may become ineffective in a proportion of patients. This article highlights the different molecular mechanisms of acquired resistance being developed during treatment with TKIs as well as the pharmacological strategies to overcome it. Moreover, it gives an overview of novel drugs and therapies that are aiming in overcoming drug resistance, loss of response, and kinase domain mutations. PMID:26917943

The Influence of Reduced Gravity on the Crystal Growth of Electronic Materials

NASA Technical Reports Server (NTRS)

Su, Ching-Hua; Gillies, D. C.; Szofran, F. R.; Watring, D. A.; Lehoczky, S. L.

1996-01-01

The imperfections in the grown crystals of electronic materials, such as compositional nonuniformity, dopant segregation and crystalline structural defects, are detrimental to the performance of the opto-electronic devices. Some of these imperfections can be attributed to effects caused by Earth gravity during crystal growth process and four areas have been identified as the uniqueness of material processing in reduced gravity environment. The significant results of early flight experiments, i.e. prior to space shuttle era, are briefly reviewed followed by an elaborated review on the recent flight experiments conducted on shuttle missions. The results are presented for two major growth methods of electronic materials: melt and vapor growth. The use of an applied magnetic field in the melt growth of electrically conductive melts on Earth to simulate the conditions of reduced gravity has been investigated and it is believed that the superimposed effect of moderate magnetic fields and the reduced gravity environment of space can result in reduction of convective intensities to the extent unreachable by the exclusive use of magnet on Earth or space processing. In the Discussions section each of the significant results of the flight experiments is attributed to one of the four effects of reduced gravity and the unresolved problems on the measured mass fluxes in some of the vapor transport flight experiments are discussed.

Resveratrol for breast cancer prevention and therapy: Preclinical evidence and molecular mechanisms.

PubMed

Sinha, Dona; Sarkar, Nivedita; Biswas, Jaydip; Bishayee, Anupam

2016-10-01

Globally, breast cancer is the most frequently diagnosed cancer among women. The major unresolved problems with metastatic breast cancer is recurrence after receiving objective response to chemotherapy, drug-induced side effects of first line chemotherapy and delayed response to second line of treatment. Unfortunately, very few options are available as third line treatment. It is clear that under such circumstances there is an urgent need for new and effective drugs. Phytochemicals are among the most promising chemopreventive treatment options for the management of cancer. Resveratrol (3,5,4'-trihydroxy-trans-stilbene), a non-flavonoid polyphenol present in several dietary sources, including grapes, berries, soy beans, pomegranate and peanuts, has been shown to possess a wide range of health benefits through its effect on a plethora of molecular targets.The present review encompasses the role of resveratrol and its natural/synthetic analogue in the light of their efficacy against tumor cell proliferation, metastasis, epigenetic alterations and for induction of apoptosis as well as sensitization toward chemotherapeutic drugs in various in vitro and in vivo models of breast cancer. The roles of resveratrol as a phytoestrogen, an aromatase inhibitor and in stem cell therapy as well as adjuvent treatment are also discussed. This review explores the full potential of resveratrol in breast cancer prevention and treatment with current limitations, challenges and future directions of research. Copyright © 2016 Elsevier Ltd. All rights reserved.

A Military-Centered Approach to Neuroprotection for Traumatic Brain Injury

PubMed Central

Shear, Deborah A.; Tortella, Frank C.

2013-01-01

Studies in animals show that many compounds and therapeutics have the potential to greatly reduce the morbidity and post-injury clinical sequela for soldiers experiencing TBI. However, to date there are no FDA approved drugs for the treatment of TBI. In fact, expert opinion suggests that combination therapies will be necessary to treat any stage of TBI recovery. Our approach to this research effort is to conduct comprehensive pre-clinical neuroprotection studies in military-relevant animal models of TBI using the most promising neuroprotective agents. In addition, emerging efforts incorporating novel treatment strategies such as stem cell based therapies and alternative therapeutic approaches will be discussed. The development of a non-surgical, non-invasive brain injury therapeutic clearly addresses a major, unresolved medical problem for the Combat Casualty Care Research Program. Since drug discovery is too expensive to be pursued by DOD in the TBI arena, this effort capitalizes on partnerships with the Private Sector (Pharmaceutical Companies) and academic collaborations (Operation Brain Trauma Therapy Consortium) to study therapies already under advanced development. Candidate therapies selected for research include drugs that are aimed at reducing the acute and delayed effects of the traumatic incident, stem cell therapies aimed at brain repair, and selective brain cooling to stabilize cerebral metabolism. Each of these efforts can also focus on combination therapies targeting multiple mechanisms of neuronal injury. PMID:23781213

Not So Rare Earth? New Developments in Understanding the Origin of the Earth and Moon

NASA Technical Reports Server (NTRS)

Righter, Kevin

2007-01-01

A widely accepted model for the origin of the Earth and Moon has been a somewhat specific giant impact scenario involving an impactor to proto-Earth mass ratio of 3:7, occurring 50-60 Ma after T(sub 0), when the Earth was only half accreted, with the majority of Earth's water then accreted after the main stage of growth, perhaps from comets. There have been many changes to this specific scenario, due to advances in isotopic and trace element geochemistry, more detailed, improved, and realistic giant impact and terrestrial planet accretion modeling, and consideration of terrestrial water sources other than high D/H comets. The current scenario is that the Earth accreted faster and differentiated quickly, the Moon-forming impact could have been mid to late in the accretion process, and water may have been present during accretion. These new developments have broadened the range of conditions required to make an Earth-Moon system, and suggests there may be many new fruitful avenues of research. There are also some classic and unresolved problems such as the significance of the identical O isotopic composition of the Earth and Moon, the depletion of volatiles on the lunar mantle relative to Earth's, the relative contribution of the impactor and proto-Earth to the Moon's mass, and the timing of Earth's possible atmospheric loss relative to the giant impact.

Brain Networks for Working Memory and Factors of Intelligence Assessed in Males and Females with fMRI and DTI

ERIC Educational Resources Information Center

Tang, C. Y.; Eaves, E. L.; Ng, J. C.; Carpenter, D. M.; Mai, X.; Schroeder, D. H.; Condon, C. A.; Colom, R.; Haier, R. J.

2010-01-01

Neuro-imaging studies of intelligence implicate the importance of a parietal-frontal network. One unresolved issue is whether this network underlies a general factor of intelligence ("g") or other specific cognitive factors. A second unresolved issue is whether males and females use different parts of this network. Here we obtained intelligence…

[Attachment Representation and Emotion Regulation in Patients with Burnout Syndrome].

PubMed

Söllner, Wolfgang; Behringer, Johanna; Böhme, Stephanie; Stein, Barbara; Reiner, Iris; Spangler, Gottfried

2016-06-01

Burnout describes a syndrome of exhaustion resulting from insufficient coping with work-related distress. We investigated if patients that are being clinically treated for burnout show insecure and unresolved attachment representation more often compared with healthy controls. 50 out of 60 consecutive burnout patients participated in the study. Mental representation of attachment was measured by using the Adult Attachment Interview. Additionally, we administered the Self Report Questionnaire to Assess Emotional Experience and Emotion Regulation and several burnout specific questionnaires. A population sample was used as control group. Burnout patients were classified as insecurely attached significantly more often than controls. Unresolved attachment status concerning loss or trauma was found significantly more often within the burnout sample. Patients with insecure attachment representation reported a lower subjective significance of work. Patients with avoidant insecure attachment showed more depersonalisation. Patients with unresolved loss/trauma reported less social support. They showed more passive-negative emotion experience and emotion regulation characterized by externalization. The results of the study suggest that an insecure or unresolved attachment representation might constitute an intrapersonal risk factor for the development of burnout syndrome. © Georg Thieme Verlag KG Stuttgart · New York.

Treating Unresolved Grief and Posttraumatic Stress Symptoms in Orphaned Children in Tanzania: Group-based Trauma-focused Cognitive Behavioral Therapy

PubMed Central

O’Donnell, Karen; Dorsey, Shannon; Gong, Wenfeng; Ostermann, Jan; Whetten, Rachel; Cohen, Judith A.; Itemba, Dafrosa; Manongi, Rachel; Whetten, Kathryn

2015-01-01

The study was designed to test the feasibility and child clinical outcomes for a group-based application of Trauma-focused Cognitive Behavior Therapy (TF-CBT) for orphaned children with unresolved grief in Moshi, Tanzania. Sixty-four orphaned children with at least mild symptoms of unresolved grief and/or traumatic stress and their guardians participated in the open trial. The evidence-based TF-CBT protocol was adapted for group delivery, resulting in 12 weekly sessions for child and guardians separately with conjoint activities and three individual visits. Using a task-sharing approach, the intervention was delivered by lay counselors with no prior mental health experience. Primary outcomes assessed were symptoms of unresolved grief and posttraumatic stress (PTS); secondary outcomes included symptoms of depression and overall behavioral adjustment. All assessments were conducted pre-treatment, post-treatment, and 3- and 12-months after the end of treatment. Results showed improved scores on all outcomes post-treatment, sustained at 3 and 12 months. Effect sizes (Cohen’s d) for baseline to post-treatment were 1.36 for child reported grief symptoms; 1.87 for child-reported PTS, and 1.15 for caregiver report of child PTS. PMID:25418514

Waiting for Brandon: How Readers Respond to Small Mysteries

PubMed Central

Gerrig, Richard J.; Love, Jessica; McKoon, Gail

2009-01-01

When readers experience narratives they often encounter small mysteries—questions that a text raises that are not immediately settled. In our experiments, participants read stories that introduced characters by proper names (e.g., “It’s just that Brandon hasn’t called in so long”). Resolved versions of the stories specified the functions those characters’ assumed in their narrative worlds with respect to the other characters (e.g., Brandon was identified as the speaker’s grandson); unresolved versions of the stories did not immediately provide that information. We predicted that characters whose functions were still unresolved would remain relatively accessible in the discourse representations. We tested that prediction in Experiments 1 and 2 by asking participants to indicate whether a name (e.g., Brandon) had appeared in the story. Participants responded most swiftly when the characters remained unresolved. In the latter experiments, we demonstrated that the presence of an unresolved character disrupted processing of information that followed that character’s introduction (Experiment 3) but not information that preceded that introduction (Experiment 4). These results support the general importance of providing a theoretical account of readers’ responses to narrative mysteries. PMID:20046984

Satellite power system concept development and evaluation program. Volume 2: System definition

NASA Technical Reports Server (NTRS)

1981-01-01

The system level results of the system definition studies performed by NASA as a part of the Department of Energy/NASA satellite power system concept development and evaluation program are summarized. System requirements and guidelines are discussed as well as the major elements that comprise the reference system and its design options. Alternative system approaches including different system sizes, solid state amplifier (microwave) concepts, and laser power transmission system cost summaries are reviewed. An overview of the system analysis and planning efforts is included. The overall study led to the conclusion that the reference satellite power system concept is a feasible baseload source of electrical power and, within the assumed guidelines, the minimum cost per kilowatt is achieved at the maximum output of 5 gigawatts to the utility grid. Major unresolved technical issues include maximum allowable microwave power density in the ionosphere and performance/mass characteristics of laser power transmission systems.

Structural insights into ligand recognition and selectivity for class A, B, and C GPCRs

PubMed Central

Lee, Sang-Min; Booe, Jason M.; Pioszak, Augen A.

2015-01-01

The G protein-coupled receptor (GPCR) superfamily constitutes the largest collection of cell surface signaling proteins with approximately 800 members in the human genome. GPCRs regulate virtually all aspects of physiology and they are an important class of drug targets with ~30% of drugs on the market targeting a GPCR. Breakthroughs in GPCR structural biology in recent years have significantly expanded our understanding of GPCR structure and function and ushered in a new era of structure-based drug design for GPCRs. Crystal structures for nearly thirty distinct GPCRs are now available including receptors from each of the major classes, A, B, C, and F. These structures provide a foundation for understanding the molecular basis of GPCR pharmacology. Here, we review structural mechanisms of ligand recognition and selectivity of GPCRs with a focus on selected examples from classes A, B, and C, and we highlight major unresolved questions for future structural studies. PMID:25981303

Classifying unresolved objects from simulated space data.

NASA Technical Reports Server (NTRS)

Nalepka, R. F.; Hyde, P. D.

1973-01-01

A multispectral scanner data set gathered at a flight altitude of 10,000 ft. over an agricultural area was modified to simulate the spatial resolution of the spacecraft scanners. Signatures were obtained for several major crops and their proportions were estimated over a large area. For each crop, a map was generated to show its approximate proportion in each resolution element, and hence its distribution over the area of interest. A statistical criterion was developed to identify data points that may not represent a mixture of the specified crops. This allows for great reduction in the effect of unknown or alien objects on the estimated proportions. This criterion can be used to locate special features, such as roads or farm houses. Preliminary analysis indicates a high level of consistency between estimated proportions and available ground truth. Large concentrations of major crops show up especially well on the maps.

Investigating the physical and geometrical properties of the dusty torus in QSO

NASA Astrophysics Data System (ADS)

Martínez-Paredes, M.; González-Martín, O.; Aretxaga, I.; Alonso-Herrero, A.

2017-07-01

Usining mid-IR high angular resolution (0.3 arcsec) data from CanariCam on the 10.4m Gran Telescopio CANARIAS we study the mid-IR nuclear emission of a nearby (z<0.1) sample of QSOs. The QSOs are selected with N-band flux (fN>0.02 Jy) and hard X-ray flux (fX(2-10 keV)>1043 erg s-1). From the analysis of this data we find that the mid-IR emission is unresolved at scales of a few hundred of pc. We use unresolved emission at H-band (e.g., Veilleux et al. 2009b) and the IRS-Spitzer spectrum (e.g., Schweitzer et al. 2006) to build near- to mid-IR unresolved spectral energy distribution (SEDs).

Physician staffed helicopter emergency medical systems can provide advanced trauma life support in mountainous and remote areas.

PubMed

Ausserer, Julia; Moritz, Elizabeth; Stroehle, Matthias; Brugger, Hermann; Strapazzon, Giacomo; Rauch, Simon; Mair, Peter

2017-01-01

In remote and mountainous areas, helicopter emergency medical systems (HEMS) are used to expedite evacuation and provide pre-hospital advanced trauma life support (ATLS) in major trauma victims. Aim of the study was to investigate feasibility of ATLS in HEMS mountain rescue missions and its influence on patient condition at hospital admission. 58 major trauma victims (Injury Severity Score ≥16), evacuated by physician staffed HEMS from remote and mountainous areas in the State of Tyrol, Austria between 1.1.2011 and 31.12.2013. Pre-hospital time exceeded 90min in 24 (44%) cases. 31 (53%) patients suffered critical impairment of at least one vital function (systolic blood pressure <90mmHg, GCS <10, or respiratory rate <10 or >30). 4 (6.9%) of 58 patients died prior to hospital admission. Volume resuscitation was restrictive: 18 (72%) of 25 hypotensive patients received ≤500ml fluids and blood pressure was increased >90mmHg at hospital admission in only 9 (36%) of these 25 patients. 8 (50%) of 16 brain trauma patients with a blood pressure <90mmHg remained hypotensive at hospital admission. Endotracheal intubation was accomplished without major complications in 15 (79%) of 19 patients with a Glasgow Coma Scale score <10. Rope operations were necessary in 40 (69%) of 58 cases and ATLS was started before hoist evacuation in 30 (75%) of them. The frequent combination of prolonged pre-hospital times, with critical impairment of vital functions, supports the need for early ATLS in HEMS mountain rescue missions. Pre-hospital endotracheal intubation is possible with a high success and low complication rate also in a mountain rescue scenario. Pre-hospital volume resuscitation is restrictive and hypotension is reversed at hospital admission in only one third of patients. Prolonged pre-hospital hypotension remains an unresolved problem in half of all brain trauma patients and indicates the difficulties to increase blood pressure to a desired level in a mountain rescue scenario. Despite technical considerations, on-site ATLS is feasible for an experienced emergency physician in the majority of rope rescue operations. Copyright © 2016 Elsevier Ltd. All rights reserved.

Wynoochee Hydropower/Fish Hatchery: Feasibility Report and Environmental Impact Statement.

DTIC Science & Technology

1982-09-30

Unresolved Issues. There are no unresolved issues associated with the Wynoochee hydropower/fish hatchery plan. 4. Relationship to Environmental...Requirements.l/ The relationship of the Wynoochee hydropower/fish hatchery plan to environmental requirements is summarized in the following table...Implementation of the plan would I/The relationship of the satellite fish station to the environmental requirements is not included in this discussion. Compliance

Pacific-wide contrast highlights resistance of reef calcifiers to ocean acidification.

PubMed

Comeau, S; Carpenter, R C; Nojiri, Y; Putnam, H M; Sakai, K; Edmunds, P J

2014-09-07

Ocean acidification (OA) and its associated decline in calcium carbonate saturation states is one of the major threats that tropical coral reefs face this century. Previous studies of the effect of OA on coral reef calcifiers have described a wide variety of outcomes for studies using comparable partial pressure of CO2 (pCO2) ranges, suggesting that key questions remain unresolved. One unresolved hypothesis posits that heterogeneity in the response of reef calcifiers to high pCO2 is a result of regional-scale variation in the responses to OA. To test this hypothesis, we incubated two coral taxa (Pocillopora damicornis and massive Porites) and two calcified algae (Porolithon onkodes and Halimeda macroloba) under 400, 700 and 1000 μatm pCO2 levels in experiments in Moorea (French Polynesia), Hawaii (USA) and Okinawa (Japan), where environmental conditions differ. Both corals and H. macroloba were insensitive to OA at all three locations, while the effects of OA on P. onkodes were location-specific. In Moorea and Hawaii, calcification of P. onkodes was depressed by high pCO2, but for specimens in Okinawa, there was no effect of OA. Using a study of large geographical scale, we show that resistance to OA of some reef species is a constitutive character expressed across the Pacific. © 2014 The Author(s) Published by the Royal Society. All rights reserved.

Novel residual-based large eddy simulation turbulence models for incompressible magnetohydrodynamics

NASA Astrophysics Data System (ADS)

Sondak, David

The goal of this work was to develop, introduce, and test a promising computational paradigm for the development of turbulence models for incompressible magnetohydrodynamics (MHD). MHD governs the behavior of an electrically conducting fluid in the presence of an external electromagnetic (EM) field. The incompressible MHD model is used in many engineering and scientific disciplines from the development of nuclear fusion as a sustainable energy source to the study of space weather and solar physics. Many interesting MHD systems exhibit the phenomenon of turbulence which remains an elusive problem from all scientific perspectives. This work focuses on the computational perspective and proposes techniques that enable the study of systems involving MHD turbulence. Direct numerical simulation (DNS) is not a feasible approach for studying MHD turbulence. In this work, turbulence models for incompressible MHD were developed from the variational multiscale (VMS) formulation wherein the solution fields were decomposed into resolved and unresolved components. The unresolved components were modeled with a term that is proportional to the residual of the resolved scales. Two additional MHD models were developed based off of the VMS formulation: a residual-based eddy viscosity (RBEV) model and a mixed model that partners the VMS formulation with the RBEV model. These models are endowed with several special numerical and physics features. Included in the numerical features is the internal numerical consistency of each of the models. Physically, the new models are able to capture desirable MHD physics such as the inverse cascade of magnetic energy and the subgrid dynamo effect. The models were tested with a Fourier-spectral numerical method and the finite element method (FEM). The primary test problem was the Taylor-Green vortex. Results comparing the performance of the new models to DNS were obtained. The performance of the new models was compared to classic and cutting-edge dynamic Smagorinsky eddy viscosity (DSEV) models. The new models typically outperform the classical models.

Combination of binaural and harmonic masking release effects in the detection of a single component in complex tones.

PubMed

Klein-Hennig, Martin; Dietz, Mathias; Hohmann, Volker

2018-03-01

Both harmonic and binaural signal properties are relevant for auditory processing. To investigate how these cues combine in the auditory system, detection thresholds for an 800-Hz tone masked by a diotic (i.e., identical between the ears) harmonic complex tone were measured in six normal-hearing subjects. The target tone was presented either diotically or with an interaural phase difference (IPD) of 180° and in either harmonic or "mistuned" relationship to the diotic masker. Three different maskers were used, a resolved and an unresolved complex tone (fundamental frequency: 160 and 40 Hz) with four components below and above the target frequency and a broadband unresolved complex tone with 12 additional components. The target IPD provided release from masking in most masker conditions, whereas mistuning led to a significant release from masking only in the diotic conditions with the resolved and the narrowband unresolved maskers. A significant effect of mistuning was neither found in the diotic condition with the wideband unresolved masker nor in any of the dichotic conditions. An auditory model with a single analysis frequency band and different binaural processing schemes was employed to predict the data of the unresolved masker conditions. Sensitivity to modulation cues was achieved by including an auditory-motivated modulation filter in the processing pathway. The predictions of the diotic data were in line with the experimental results and literature data in the narrowband condition, but not in the broadband condition, suggesting that across-frequency processing is involved in processing modulation information. The experimental and model results in the dichotic conditions show that the binaural processor cannot exploit modulation information in binaurally unmasked conditions. Copyright © 2017 Elsevier B.V. All rights reserved.

Tracking initially unresolved thrusting objects in 3D using a single stationary optical sensor

NASA Astrophysics Data System (ADS)

Lu, Qin; Bar-Shalom, Yaakov; Willett, Peter; Granström, Karl; Ben-Dov, R.; Milgrom, B.

2017-05-01

This paper considers the problem of estimating the 3D states of a salvo of thrusting/ballistic endo-atmospheric objects using 2D Cartesian measurements from the focal plane array (FPA) of a single fixed optical sensor. Since the initial separations in the FPA are smaller than the resolution of the sensor, this results in merged measurements in the FPA, compounding the usual false-alarm and missed-detection uncertainty. We present a two-step methodology. First, we assume a Wiener process acceleration (WPA) model for the motion of the images of the projectiles in the optical sensor's FPA. We model the merged measurements with increased variance, and thence employ a multi-Bernoulli (MB) filter using the 2D measurements in the FPA. Second, using the set of associated measurements for each confirmed MB track, we formulate a parameter estimation problem, whose maximum likelihood estimate can be obtained via numerical search and can be used for impact point prediction. Simulation results illustrate the performance of the proposed method.

Fuzzy Logic-Based Guaranteed Lifetime Protocol for Real-Time Wireless Sensor Networks.

PubMed

Shah, Babar; Iqbal, Farkhund; Abbas, Ali; Kim, Ki-Il

2015-08-18

Few techniques for guaranteeing a network lifetime have been proposed despite its great impact on network management. Moreover, since the existing schemes are mostly dependent on the combination of disparate parameters, they do not provide additional services, such as real-time communications and balanced energy consumption among sensor nodes; thus, the adaptability problems remain unresolved among nodes in wireless sensor networks (WSNs). To solve these problems, we propose a novel fuzzy logic model to provide real-time communication in a guaranteed WSN lifetime. The proposed fuzzy logic controller accepts the input descriptors energy, time and velocity to determine each node's role for the next duration and the next hop relay node for real-time packets. Through the simulation results, we verified that both the guaranteed network's lifetime and real-time delivery are efficiently ensured by the new fuzzy logic model. In more detail, the above-mentioned two performance metrics are improved up to 8%, as compared to our previous work, and 14% compared to existing schemes, respectively.

[Nursing cares in constipation of the oncology patient].

PubMed

Cordero-Ponce, Montserrat; Romero-Sánchez, Isabel María

2008-01-01

The importance of constipation lies in its frequency, even among the healthy. The incidence of constipation in oncological patients is 70-80% in the final stage, 40-50% in advanced disease, and 90% in patients with aggressive cancer. This disorder is not only uncomfortable for the patient but also causes complications. Prolonged constipation can cause abdominal pain and even increase the pain caused by the tumor and stronger pain relief can be required when the constipation is unresolved. Among the complications that can occur are intestinal obstruction, diarrhea by spillage, urinary dysfunction, anorexia, nausea and vomiting, restlessness, malaise, and confusion. When analyzing this problem, we aim to unify criteria and nursing interventions, emphasize the importance of prevention, and solve the problem. Health education of both the patient and the main caregiver aid control of this disorder after discharge. The patient will be able to identify the appearance of constipation, its causes and symptoms and will be familiar with the treatment and when and where to go to review it.

Unresolved Issues With Inner Magnetosphere-Ionosphere Coupling

NASA Technical Reports Server (NTRS)

Gallagher, D. L.; Khazanov, G.

2004-01-01

Dipolarization and the release of stored magnetic energy is strongly evident in the energized plasma sheet electrons and ions injected earthward from the magnetotail. While some of these plasma are presumed lost into the dayside magnetosheath, much of the energy is dissipated into the ionosphere through electric currents, through collisions into low energy plasma, and into plasma waves, which then go on to heat and energize plasma of the inner magnetosphere. Many mechanisms for the transfer of energy and the consequences to inner magnetospheric plasma populations have been proposed. The sophistication of theoretical models to represent the interdependencies between plasma populations is rapidly increasing. However without the restraint and reality imposed on theory by relevant measurements, the degree to which specific mechanisms participate in the exchange of energy as a function of location and time cannot be known. ORBITALS offers this capability. Some of the outstanding problems in inner magnetospheric physics and the opportunities presented by the ORBITAL concept to solve problems will be discussed.

Fuzzy Logic-Based Guaranteed Lifetime Protocol for Real-Time Wireless Sensor Networks

PubMed Central

Shah, Babar; Iqbal, Farkhund; Abbas, Ali; Kim, Ki-Il

2015-01-01

Few techniques for guaranteeing a network lifetime have been proposed despite its great impact on network management. Moreover, since the existing schemes are mostly dependent on the combination of disparate parameters, they do not provide additional services, such as real-time communications and balanced energy consumption among sensor nodes; thus, the adaptability problems remain unresolved among nodes in wireless sensor networks (WSNs). To solve these problems, we propose a novel fuzzy logic model to provide real-time communication in a guaranteed WSN lifetime. The proposed fuzzy logic controller accepts the input descriptors energy, time and velocity to determine each node’s role for the next duration and the next hop relay node for real-time packets. Through the simulation results, we verified that both the guaranteed network’s lifetime and real-time delivery are efficiently ensured by the new fuzzy logic model. In more detail, the above-mentioned two performance metrics are improved up to 8%, as compared to our previous work, and 14% compared to existing schemes, respectively. PMID:26295238

Unresolved questions associated with the management of ventricular pre-excitation syndrome.

PubMed

Brembilla-Perrot, Béatrice; Girerd, Nicolas; Sellal, Jean-Marc

2018-05-13

many recent recommendations concern the management of pre-excitation syndrome. In clinical practice, they are sometimes difficult to use. The purpose of the authors was to discuss the main problems associated with this management. This article is protected by copyright. All rights reserved Three problems are encountered: 1) the reality of the absence of symptoms or the interpretation of atypical symptoms, 2) the electrocardiographic diagnosis of pre-excitation syndrome that can be missed and 3) the exact electrophysiological protocol and its interpretation used for the evaluation of the prognosis Because of significant progress largely related to the development of curative treatment, it seems easy to propose ablation in many patients despite the related risks of invasive studies and to minimize the invasive risk by only performing ablation for patients with at-risk pathways. However, there is a low risk of spontaneous events in truly asymptomatic patients and the indication of accessory pathway ablation should be discussed case by case. This article is protected by copyright. All rights reserved.

Toxicology and the biological role of methanol and ethanol: Current view.

PubMed

Pohanka, Miroslav

2016-03-01

Alcohol variants such as ethanol and methanol are simple organic compounds widely used in foods, pharmaceuticals, chemical synthesis, etc. Both are becoming an emerging health problem; abuse of ethanol containing beverages can lead to disparate health problems and methanol is highly toxic and unfit for consumption. This review summarizes the basic knowledge about ethanol and methanol toxicity, the effect mechanism on the body, the current care of poisoned individuals and the implication of alcohols in the development of diseases. Alcohol related dementia, stroke, metabolic syndrome and hepatitis are discussed as well. Besides ethanol, methanol toxicity and its biodegradation pathways are addressed. The impact of ethanol and methanol on the body is shown as case reports, along with a discussion on the possible implication of alcohol in Alzheimer's disease and antidotal therapy for methanol poisoning. The role of ethanol in cancer and degenerative disorders seems to be underestimated given the current knowledge. Treatment in case of poisoning is another issue that remains unresolved even though effective protocols and drugs exist.

Documenting the decision structure in software development

NASA Technical Reports Server (NTRS)

Wild, J. Christian; Maly, Kurt; Shen, Stewart N.

1990-01-01

Current software development paradigms focus on the products of the development process. Much of the decision making process which produces these products is outside the scope of these paradigms. The Decision-Based Software Development (DBSD) paradigm views the design process as a series of interrelated decisions which involve the identification and articulation of problems, alternates, solutions and justifications. Decisions made by programmers and analysts are recorded in a project data base. Unresolved problems are also recorded and resources for their resolution are allocated by management according to the overall development strategy. This decision structure is linked to the products affected by the relevant decision and provides a process oriented view of the resulted system. Software maintenance uses this decision view of the system to understand the rationale behind the decisions affecting the part of the system to be modified. D-HyperCase, a prototype Decision-Based Hypermedia System is described and results of applying the DBSD approach during its development are presented.

Lymphedema following treatment for breast cancer: a new approach to an old problem.

PubMed

O'Toole, Jean; Jammallo, Lauren S; Skolny, Melissa N; Miller, Cynthia L; Elliott, Krista; Specht, Michelle C; Taghian, Alphonse G

2013-11-01

Lymphedema following treatment for breast cancer can be an irreversible condition with a profound negative impact on quality of life. The lack of consensus regarding standard definitions of clinically significant lymphedema and optimal methods of measurement and quantification are unresolved problems. Inconsistencies persist regarding the appropriate timing of intervention and what forms of treatment should be the standard of care. There are reports that early detection and intervention can prevent progression, however,the Level 1 evidence to support this hypothesis has yet to be generated. To assess these controversies, we propose the implementation of a screening program to detect early lymphedema in conjunction with a randomized, prospective trial designed to generate Level 1 evidence regarding the efficacy of early intervention and appropriate treatment strategies. Collaboration among institutions that manage breast cancer patients is essential to establish a standardized approach to lymphedema and to establish guidelines for best practice. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

[Home care for the high-risk newborn infant].

PubMed

Puddu, M

2010-06-01

With increased survival of extremely low birth weigh (ELBW) and very ill infants, a lot of them are discharged with unresolved medical issues that complicate their subsequent care. Infants born preterm with low birth weight who require neonatal intensive care experience a much higher rate of hospital readmission and death during the first year after birth compared with healthy term infants. Despite initial hospital care which is one of the most expensive of all kind of hospitalization, home care services are sometimes still sparse though the high risk of this group for failure to thrive, respiratory problems, developmental delays, parenting problems. In addition, societal and economic forces have come to bear on the timing and process of discharge and home care. Moreover it takes time for the family of a high-risk infant to prepare to care for their infant in a home setting and to obtain the necessary support services and mobilize community resources. Careful preparation for discharge, good follow-up and medical home after discharge may reduce these risks.

On the possibility of a place code for the low pitch of high-frequency complex tonesa

PubMed Central

Santurette, Sébastien; Dau, Torsten; Oxenham, Andrew J.

2012-01-01

Harmonics are considered unresolved when they interact with neighboring harmonics and cannot be heard out separately. Several studies have suggested that the pitch derived from unresolved harmonics is coded via temporal fine-structure cues emerging from their peripheral interactions. Such conclusions rely on the assumption that the components of complex tones with harmonic ranks down to at least 9 were indeed unresolved. The present study tested this assumption via three different measures: (1) the effects of relative component phase on pitch matches, (2) the effects of dichotic presentation on pitch matches, and (3) listeners' ability to hear out the individual components. No effects of relative component phase or dichotic presentation on pitch matches were found in the tested conditions. Large individual differences were found in listeners' ability to hear out individual components. Overall, the results are consistent with the coding of individual harmonic frequencies, based on the tonotopic activity pattern or phase locking to individual harmonics, rather than with temporal coding of single-channel interactions. However, they are also consistent with more general temporal theories of pitch involving the across-channel summation of information from resolved and/or unresolved harmonics. Simulations of auditory-nerve responses to the stimuli suggest potential benefits to a spatiotemporal mechanism. PMID:23231119

A difficult Arctic science issue: Midlatitude weather linkages

NASA Astrophysics Data System (ADS)

Overland, James E.

2016-09-01

There is at present unresolved uncertainty whether Arctic amplification (increased air temperatures and loss of sea ice) impacts the location and intensities of recent major weather events in midlatitudes. There are three major impediments. The first is the null hypothesis where the shortness of time series since major amplification (∼15 years) is dominated by the variance of the physical process in the attribution calculation. This makes it impossible to robustly distinguish the influence of Arctic forcing of regional circulation from random events. The second is the large chaotic jet stream variability at midlatitudes producing a small Arctic forcing signal-to-noise ratio. Third, there are other potential external forcings of hemispheric circulation, such as teleconnections driven by tropical and midlatitude sea surface temperature anomalies. It is, however, important to note and understand recent emerging case studies. There is evidence for a causal connection of Barents-Kara sea ice loss, a stronger Siberian High, and cold air outbreaks into eastern Asia. Recent cold air penetrating into the southeastern United States was related to a shift in the long-wave atmospheric wind pattern and reinforced by warmer temperatures west of Greenland. Arctic Linkages is a major research challenge that benefits from an international focus on the topic.

Attachment theory: progress and future directions.

PubMed

Fearon, R M Pasco; Roisman, Glenn I

2017-06-01

Attachment is a key subfield in the area of parenting and parent-child relationships research. In this brief overview, we summarise what we consider to be the state-of-the-art of attachment research, focusing primarily on the nature and significance of attachment in infancy and early childhood. We review 4 major topics that are central issues in the scientific literature on attachment: (1) the role of the environment in the development of attachment, (2) the intergenerational transmission of patterns of attachment, (3) the stability of attachment patterns through early adulthood, and (4) the role of attachment in adjustment and maladjustment. We conclude by highlighting several critical unresolved issues and priorities for future research. Copyright © 2017. Published by Elsevier Ltd.

Ultrahigh-energy cosmic rays: physics and astrophysics at extreme energies.

PubMed

Sigl, G

2001-01-05

The origin of cosmic rays is one of the major unresolved questions in astrophysics. In particular, the highest energy cosmic rays observed have macroscopic energies up to several 10(20) electron volts and thus provide a probe of physics and astrophysics at energies unattained in laboratory experiments. Theoretical explanations range from astrophysical acceleration of charged particles, to particle physics beyond the established standard model, and processes taking place at the earliest moments of our universe. Distinguishing between these scenarios requires detectors with effective areas in the 1000-square-kilometer range, which are now under construction or in the planning stage. Close connections with gamma-ray and neutrino astrophysics add to the interdisciplinary character of this field.

Effects of metric change on safety in the workplace for selected occupations

NASA Astrophysics Data System (ADS)

Lefande, J. M.; Pokorney, J. L.

1982-04-01

The study assesses the potential safety issues of metric conversion in the workplace. A purposive sample of 35 occupations based on injury and illnesses indexes were assessed. After an analysis of workforce population, hazard analysis and measurement sensitivity of the occupations, jobs were analyzed to identify potential safety hazards by industrial hygienists, safety engineers and academia. The study's major findings were as follows: No metric hazard experience was identified. An increased exposure might occur when particular jobs and their job tasks are going the transition from customary measurement to metric measurement. Well planned metric change programs reduce hazard potential. Metric safety issues are unresolved in the aviation industry.

Function in job seekers with mental illness and drug and alcohol problems who access community based disability employment services.

PubMed

Matthews, Lynda R; Harris, Lynne M; Jaworski, Alison; Alam, Ashraful; Bozdag, Gokcen

2013-03-01

This study identified functioning, health, and social needs in jobseekers with mental disorders independently assessed as having capacity to work and referred to disability employment services. Differences in function between jobseekers with mental illness alone and with additional drug and alcohol problems were examined with view to identifying interventions for vocational rehabilitation. A convenience sample of 116 jobseekers completed BASIS-32, CANSAS, AUDIT, DAST-10 and 6 items from the EXIT interview and were divided into two groups: mental illness only, and additional drug and alcohol issues (AUDIT total score >8 and/or DAST total score >3). Analysis of variance was used to determine group differences. Jobseekers reported low-moderate problems with function. Over 40% of the sample reported unresolved psychological distress, physical health needs, and social/daytime activity needs. Thirty-five jobseekers (30%) had additional drug and alcohol problems and reported significantly greater difficulty with impulsive/addictive behavior and poorer memory and executive function than the mental illness only group. No significant differences were identified in past work functioning. Screening all job seekers for psychological, physical, and social needs to identify suitable treatment and rehabilitation strategies and providing interventions that improve emotional regulation and executive function for job seekers with additional drug and alcohol problems may improve employability of job seekers accessing disability employment services.

Anaesthetic perioperative management of patients with pancreatic cancer

PubMed Central

De Pietri, Lesley; Montalti, Roberto; Begliomini, Bruno

2014-01-01

Pancreatic cancer remains a significant and unresolved therapeutic challenge. Currently, the only curative treatment for pancreatic cancer is surgical resection. Pancreatic surgery represents a technically demanding major abdominal procedure that can occasionally lead to a number of pathophysiological alterations resulting in increased morbidity and mortality. Systemic, rather than surgical complications, cause the majority of deaths. Because patients are increasingly referred to surgery with at advanced ages and because pancreatic surgery is extremely complex, anaesthesiologists and surgeons play a crucial role in preoperative evaluations and diagnoses for surgical intervention. The anaesthetist plays a key role in perioperative management and can significantly influence patient outcome. To optimise overall care, patients should be appropriately referred to tertiary centres, where multidisciplinary teams (surgical, medical, radiation oncologists, gastroenterologists, interventional radiologists and anaesthetists) work together and where close cooperation between surgeons and anaesthesiologists promotes the safe performance of major gastrointestinal surgeries with acceptable morbidity and mortality rates. In this review, we sought to provide simple daily recommendations to the clinicians who manage pancreatic surgery patients to make their work easier and suggest a joint approach between surgeons and anaesthesiologists in daily decision making. PMID:24605028

Occurrence and sources of natural and anthropogenic lipid tracers in surface soils from arid urban areas of Saudi Arabia.

PubMed

Rushdi, Ahmed I; Al-Mutlaq, Khalid F; El-Mubarak, Aarif H; Al-Saleh, Mohammed A; El-Otaibi, Mubarak T; Ibrahim, Sami M M; Simoneit, Bernd R T

2016-01-01

Soil particles contain a variety of natural and anthropogenic organic components, and in urban areas can be considered as local collectors of pollutants. Surface soil samples were taken from ten urban areas in Riyadh during early winter of 2007. They were extracted with dichloromethane-methanol mixture and the extracts were analyzed by gas chromatography-mass spectrometry. The major compounds were unresolved complex mixture (UCM), plasticizers, n-alkanes, carbohydrates, n-alkanoic acids, hopanes, n-alkanols, and sterols. Vegetation detritus was the major natural source of organic compounds (24.0 ± 15.7%) in samples from areas with less human activities and included n-alkanes, n-alkanoic acids, n-alkanols, sterols and carbohydrates. Vehicular emission products and discarded plastics were the major anthropogenic sources in the soil particles (53.3 ± 21.3% and 22.7 ± 10.7%, respectively). The anthropogenic tracers were UCM, plasticizers, n-alkanes, hopanes and traces of steranes. Vegetation and human activities control the occurrence and distribution of natural and anthropogenic extractable organic matter in this arid urban area. Copyright © 2015 Elsevier Ltd. All rights reserved.

Deriving physical parameters of unresolved star clusters. V. M 31 PHAT star clusters

NASA Astrophysics Data System (ADS)

de Meulenaer, P.; Stonkutė, R.; Vansevičius, V.

2017-06-01

Context. This study is the fifth of a series that investigates the degeneracy and stochasticity problems present in the determination of physical parameters such as age, mass, extinction, and metallicity of partially resolved or unresolved star cluster populations in external galaxies when using HST broad-band photometry. Aims: In this work we aim to derive parameters of star clusters using models with fixed and free metallicity based on the HST WFC3+ACS photometric system. The method is applied to derive parameters of a subsample of 1363 star clusters in the Andromeda galaxy observed with the HST. Methods: Following Paper III, we derive the star cluster parameters using a large grid of stochastic models that are compared to the six observed integrated broad-band WFC3+ACS magnitudes of star clusters. Results: We show that the age, mass, and extinction of the M 31 star clusters, derived assuming fixed solar metallicity, are in agreement with previous studies. We also demonstrate the ability of the WFC3+ACS photometric system to derive metallicity of star clusters older than 1 Gyr. We show that the metallicity derived using broad-band photometry of 36 massive M 31 star clusters is in good agreement with the metallicity derived using spectroscopy. Table 1 is only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/602/A112

Polyploidy and its effect on evolutionary success: old questions revisited with new tools

PubMed Central

Madlung, A

2013-01-01

Polyploidy, the condition of possessing more than two complete genomes in a cell, has intrigued biologists for almost a century. Polyploidy is found in many plants and some animal species and today we know that polyploidy has had a role in the evolution of all angiosperms. Despite its widespread occurrence, the direct effect of polyploidy on evolutionary success of a species is still largely unknown. Over the years many attractive hypotheses have been proposed in an attempt to assign functionality to the increased content of a duplicated genome. Among these hypotheses are the proposal that genome doubling confers distinct advantages to a polyploid and that these advantages allow polyploids to thrive in environments that pose challenges to the polyploid's diploid progenitors. This article revisits these long-standing questions and explores how the integration of recent genomic developments with ecological, physiological and evolutionary perspectives has contributed to addressing unresolved problems about the role of polyploidy. Although unsatisfactory, the current conclusion has to be that despite significant progress, there still isn't enough information to unequivocally answer many unresolved questions about cause and effect of polyploidy on evolutionary success of a species. There is, however, reason to believe that the increasingly integrative approaches discussed here should allow us in the future to make more direct connections between the effects of polyploidy on the genome and the responses this condition elicits from the organism living in its natural environment. PMID:23149459

Contributions of clinical disconnections and unresolved conflict to failures in intrapartum safety

PubMed Central

Lyndon, Audrey; Zlatnik, Marya G.; Maxfield, David G.; Lewis, Annie; McMillan, Chase; Kennedy, Holly Powell

2014-01-01

Objective To explore clinician perspectives on whether they experience difficulty resolving patient-related concerns or observe problems with the performance or behavior of colleagues involved in intrapartum care. Design Qualitative descriptive study of physician, nursing, and midwifery professional association members. Participants and Setting Participants (N=1932) were drawn from the membership lists of the Association of Women’s Health, Obstetric, and Neonatal Nurses (AWHONN), American College of Obstetricians and Gynecologists (ACOG), American College of Nurse Midwives (ACNM), and Society for Maternal-Fetal Medicine (SMFM). Methods Email survey with multiple choice and free text responses. Descriptive statistics and inductive thematic analysis were used to characterize the data. Results Forty-seven percent of participants reported experiencing situations in which patients were put at risk due to failure of team members to listen or respond to a concern. Thirty-seven percent reported unresolved concerns regarding another clinician’s performance. The overarching theme was clinical disconnection, which included disconnections between clinicians about patient needs and plans of care and disconnections between clinicians and administration about the support required to provide safe and appropriate clinical care. Lack of responsiveness to concerns by colleagues and administration contributed to resignation and defeatism among participants who had experienced such situations. Conclusion Despite encouraging progress in developing cultures of safety in individual centers and systems, significant work is needed to improve collaboration and reverse historic normalization of both systemic disrespect and overt disruptive behaviors in intrapartum care. PMID:24354506

Improved Cloud and Snow Screening in MAIAC Aerosol Retrievals Using Spectral and Spatial Analysis

NASA Technical Reports Server (NTRS)

Lyapustin, A.; Wang, Y.; Laszlo, I.; Kokrkin, S.

2012-01-01

An improved cloud/snow screening technique in the Multi-Angle Implementation of Atmospheric Correction (MAIAC) algorithm is described. It is implemented as part of MAIAC aerosol retrievals based on analysis of spectral residuals and spatial variability. Comparisons with AERONET aerosol observations and a large-scale MODIS data analysis show strong suppression of aerosol optical thickness outliers due to unresolved clouds and snow. At the same time, the developed filter does not reduce the aerosol retrieval capability at high 1 km resolution in strongly inhomogeneous environments, such as near centers of the active fires. Despite significant improvement, the optical depth outliers in high spatial resolution data are and will remain the problem to be addressed by the application-dependent specialized filtering techniques.

Intelligence and homosexuality.

PubMed

Kanazawa, Satoshi

2012-09-01

The origin of preferences and values is an unresolved theoretical problem in behavioural sciences. The Savanna-IQ Interaction Hypothesis, derived from the Savanna Principle and a theory of the evolution of general intelligence, suggests that more intelligent individuals are more likely to acquire and espouse evolutionarily novel preferences and values than less intelligent individuals, but general intelligence has no effect on the acquisition and espousal of evolutionarily familiar preferences and values. Ethnographies of traditional societies suggest that exclusively homosexual behaviour was probably rare in the ancestral environment, so the Hypothesis would predict that more intelligent individuals are more likely to identify themselves as homosexual and engage in homosexual behaviour. Analyses of three large, nationally representative samples (two of which are prospectively longitudinal) from two different nations confirm the prediction.

Care of the Chronically Ill at Home: An Unresolved Dilemma in Health Policy for the United States

PubMed Central

Buhler-Wilkerson, Karen

2007-01-01

The problems of caring for patients with disabling illnesses who neither get well nor die are not new. Such patients have always required assistance at home from family, benevolent volunteers, or paid caregivers. Despite two centuries of experimentation, however, no agreement exists concerning the balance between the public and private resources to be allocated through state funding, private insurance, and family contributions for the daily and routine care at home for chronically ill persons of all ages. This article examines these issues and the unavoidable tensions between fiscal reality and legitimate need. It also uses historical and policy analyses to explain why home care has never become the cornerstone for caring for the chronically ill. PMID:18070332

Inorganic scintillating materials and scintillation detectors

PubMed Central

YANAGIDA, Takayuki

2018-01-01

Scintillation materials and detectors that are used in many applications, such as medical imaging, security, oil-logging, high energy physics and non-destructive inspection, are reviewed. The fundamental physics understood today is explained, and common scintillators and scintillation detectors are introduced. The properties explained here are light yield, energy non-proportionality, emission wavelength, energy resolution, decay time, effective atomic number and timing resolution. For further understanding, the emission mechanisms of scintillator materials are also introduced. Furthermore, unresolved problems in scintillation phenomenon are considered, and my recent interpretations are discussed. These topics include positive hysteresis, the co-doping of non-luminescent ions, the introduction of an aimed impurity phase, the excitation density effect and the complementary relationship between scintillators and storage phosphors. PMID:29434081

Stationarity: Wanted dead or alive?

USGS Publications Warehouse

Lins, Larry F.; Cohn, Timothy A.

2011-01-01

Aligning engineering practice with natural process behavior would appear, on its face, to be a prudent and reasonable course of action. However, if we do not understand the long-term characteristics of hydroclimatic processes, how does one find the prudent and reasonable course needed for water management? We consider this question in light of three aspects of existing and unresolved issues affecting hydroclimatic variability and statistical inference: Hurst-Kolmogorov phenomena; the complications long-term persistence introduces with respect to statistical understanding; and the dependence of process understanding on arbitrary sampling choices. These problems are not easily addressed. In such circumstances, humility may be more important than physics; a simple model with well-understood flaws may be preferable to a sophisticated model whose correspondence to reality is uncertain.

Nonlinear Inference in Partially Observed Physical Systems and Deep Neural Networks

NASA Astrophysics Data System (ADS)

Rozdeba, Paul J.

The problem of model state and parameter estimation is a significant challenge in nonlinear systems. Due to practical considerations of experimental design, it is often the case that physical systems are partially observed, meaning that data is only available for a subset of the degrees of freedom required to fully model the observed system's behaviors and, ultimately, predict future observations. Estimation in this context is highly complicated by the presence of chaos, stochasticity, and measurement noise in dynamical systems. One of the aims of this dissertation is to simultaneously analyze state and parameter estimation in as a regularized inverse problem, where the introduction of a model makes it possible to reverse the forward problem of partial, noisy observation; and as a statistical inference problem using data assimilation to transfer information from measurements to the model states and parameters. Ultimately these two formulations achieve the same goal. Similar aspects that appear in both are highlighted as a means for better understanding the structure of the nonlinear inference problem. An alternative approach to data assimilation that uses model reduction is then examined as a way to eliminate unresolved nonlinear gating variables from neuron models. In this formulation, only measured variables enter into the model, and the resulting errors are themselves modeled by nonlinear stochastic processes with memory. Finally, variational annealing, a data assimilation method previously applied to dynamical systems, is introduced as a potentially useful tool for understanding deep neural network training in machine learning by exploiting similarities between the two problems.

Attachment insecurity, mentalization and their relation to symptoms in eating disorder patients.

PubMed

Kuipers, Greet S; van Loenhout, Zara; van der Ark, L Andries; Bekker, Marrie H J

2016-01-01

To investigate the relationships of attachment security and mentalization with core and co-morbid symptoms in eating disorder patients. We compared 51 eating disorder patients at the start of intensive treatment and 20 healthy controls on attachment, mentalization, eating disorder symptoms, depression, anxiety, personality disorders, psycho-neuroticism, autonomy problems and self-injurious behavior, using the Adult Attachment Interview, the SCID-I and II and several questionnaires. Compared with the controls, the eating disorder patients showed a higher prevalence of insecure attachment; eating disorder patients more often than controls received the AAI classification Unresolved for loss or abuse. They also had a lower level of mentalization and more autonomy problems. In the patient group eating disorder symptoms, depression, anxiety, psycho-neuroticism and autonomy problems were neither related to attachment security nor to mentalization; self-injurious behavior was associated with lesser attachment security and lower mentalization; borderline personality disorder was related to lower mentalization. In the control group no relations were found between attachment, mentalization and psychopathologic variables. Eating disorder patients' low level of mentalization suggests the usefulness of Mentalization Based Treatment techniques for eating disorder treatment, especially in case of self-injurious behavior and/or co-morbid borderline personality disorder.

Community response to noise: research in Central, Eastern and South-Eastern Europe and Newly Independent States.

PubMed

Jeram, Sonja; Lekaviciute, Jurgita; Krukle, Zanda; Argalasova-Sobotova, Lubica; Ristovska, Gordana; Paunovic, Katarina; Pawlaczyk-Luszczynska, Malgorzata

2013-01-01

The systems of public complaints on environmental noise were reviewed in seven countries of Central and Eastern Europe (CEE), South-East Europe (SEE), and Newly Independent States (NIS). Public complaints remain an important issue due to differences in public sensitivity to noise and due to several cases where a measurement of noise intensity does not give a satisfying solution to the problem. The unresolved problem remaining in the residential neighborhoods is the noise from pubs and restaurants that are open until late in the night. In our review, we compiled information on the institutions responsible for the implementation of environmental noise legislation and organizations that are responsible for dealing with public complaints. Information on activities for increasing public awareness on hazards rising from environmental noise and the role of civil initiative was explored. In seven countries, and among them, Slovenia, Lithuania, Latvia, Slovakia, The Former Yugoslav Republic of Macedonia, Serbia, and Poland, the responsibilities and duties are shared among different institutions at national and regional levels, depending on the noise source. The problem of gathering information on complaints and using it for improving the wellbeing and health of citizens remains often difficult and unsolved.

Molecular phylogeny of ocelloid-bearing dinoflagellates (Warnowiaceae) as inferred from SSU and LSU rDNA sequences

PubMed Central

Hoppenrath, Mona; Bachvaroff, Tsvetan R; Handy, Sara M; Delwiche, Charles F; Leander, Brian S

2009-01-01

Background Dinoflagellates represent a major lineage of unicellular eukaryotes with unparalleled diversity and complexity in morphological features. The monophyly of dinoflagellates has been convincingly demonstrated, but the interrelationships among dinoflagellate lineages still remain largely unresolved. Warnowiid dinoflagellates are among the most remarkable eukaryotes known because of their possession of highly elaborate ultrastructural systems: pistons, nematocysts, and ocelloids. Complex organelles like these are evolutionary innovations found only in a few athecate dinoflagellates. Moreover, the taxonomy of warnowiids is extremely confusing and inferences about the evolutionary history of this lineage are mired by the absence of molecular phylogenetic data from any member of the group. In this study, we provide the first molecular phylogenetic data for warnowiids and couple them with a review of warnowiid morphological features in order to formulate a hypothetical framework for understanding character evolution within the group. These data also enabled us to evaluate the evolutionary relationship(s) between warnowiids and the other group of dinoflagellates with complex organelles: polykrikoids. Results Molecular phylogenetic analyses of SSU and LSU rDNA sequences demonstrated that warnowiids form a well-supported clade that falls within the more inclusive Gymnodinium sensu stricto clade. These data also confirmed that polykrikoids are members of the Gymnodinium sensu stricto clade as well; however, a specific sister relationship between the warnowiid clade and the polykrikoid clade was unresolved in all of our analyses. Nonetheless, the new DNA sequences from different isolates of warnowiids provided organismal anchors for several previously unidentified sequences derived from environmental DNA surveys of marine biodiversity. Conclusion Comparative morphological data and molecular phylogenetic data demonstrate that the polykrikoid and the warnowiid clade are closely related to each other, but the precise branching order within the Gymnodinium sensu stricto clade remains unresolved. We regard the ocelloid as the best synapomorphy for warnowiids and infer that the most recent common ancestor of polykrikoids and warnowiids possessed both nematocysts and photosynthetic plastids that were subsequently lost during the early evolution of warnowiids. Our summary of species and genus concepts in warnowiids demonstrate that the systematics of this poorly understood group is highly problematic and a comprehensive revision is needed. PMID:19467154

Molecular phylogeny of ocelloid-bearing dinoflagellates (Warnowiaceae) as inferred from SSU and LSU rDNA sequences.

PubMed

Hoppenrath, Mona; Bachvaroff, Tsvetan R; Handy, Sara M; Delwiche, Charles F; Leander, Brian S

2009-05-25

Dinoflagellates represent a major lineage of unicellular eukaryotes with unparalleled diversity and complexity in morphological features. The monophyly of dinoflagellates has been convincingly demonstrated, but the interrelationships among dinoflagellate lineages still remain largely unresolved. Warnowiid dinoflagellates are among the most remarkable eukaryotes known because of their possession of highly elaborate ultrastructural systems: pistons, nematocysts, and ocelloids. Complex organelles like these are evolutionary innovations found only in a few athecate dinoflagellates. Moreover, the taxonomy of warnowiids is extremely confusing and inferences about the evolutionary history of this lineage are mired by the absence of molecular phylogenetic data from any member of the group. In this study, we provide the first molecular phylogenetic data for warnowiids and couple them with a review of warnowiid morphological features in order to formulate a hypothetical framework for understanding character evolution within the group. These data also enabled us to evaluate the evolutionary relationship(s) between warnowiids and the other group of dinoflagellates with complex organelles: polykrikoids. Molecular phylogenetic analyses of SSU and LSU rDNA sequences demonstrated that warnowiids form a well-supported clade that falls within the more inclusive Gymnodinium sensu stricto clade. These data also confirmed that polykrikoids are members of the Gymnodinium sensu stricto clade as well; however, a specific sister relationship between the warnowiid clade and the polykrikoid clade was unresolved in all of our analyses. Nonetheless, the new DNA sequences from different isolates of warnowiids provided organismal anchors for several previously unidentified sequences derived from environmental DNA surveys of marine biodiversity. Comparative morphological data and molecular phylogenetic data demonstrate that the polykrikoid and the warnowiid clade are closely related to each other, but the precise branching order within the Gymnodinium sensu stricto clade remains unresolved. We regard the ocelloid as the best synapomorphy for warnowiids and infer that the most recent common ancestor of polykrikoids and warnowiids possessed both nematocysts and photosynthetic plastids that were subsequently lost during the early evolution of warnowiids. Our summary of species and genus concepts in warnowiids demonstrate that the systematics of this poorly understood group is highly problematic and a comprehensive revision is needed.

Binary Systems and the Initial Mass Function

NASA Astrophysics Data System (ADS)

Malkov, O. Yu.

2017-07-01

In the present paper we discuss advantages and disadvantages of binary stars, which are important for star formation history determination. We show that to make definite conclusions of the initial mass function shape, it is necessary to study binary population well enough to correct the luminosity function for unresolved binaries; to construct the mass-luminosity relation based on wide binaries data, and to separate observational mass functions of primaries, of secondaries, and of unresolved binaries.

Distinguishing dark matter from unresolved point sources in the Inner Galaxy with photon statistics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee, Samuel K.; Lisanti, Mariangela; Safdi, Benjamin R., E-mail: samuelkl@princeton.edu, E-mail: mlisanti@princeton.edu, E-mail: bsafdi@princeton.edu

2015-05-01

Data from the Fermi Large Area Telescope suggests that there is an extended excess of GeV gamma-ray photons in the Inner Galaxy. Identifying potential astrophysical sources that contribute to this excess is an important step in verifying whether the signal originates from annihilating dark matter. In this paper, we focus on the potential contribution of unresolved point sources, such as millisecond pulsars (MSPs). We propose that the statistics of the photons—in particular, the flux probability density function (PDF) of the photon counts below the point-source detection threshold—can potentially distinguish between the dark-matter and point-source interpretations. We calculate the flux PDFmore » via the method of generating functions for these two models of the excess. Working in the framework of Bayesian model comparison, we then demonstrate that the flux PDF can potentially provide evidence for an unresolved MSP-like point-source population.« less

Unresolved Galaxy Classifier for ESA/Gaia mission: Support Vector Machines approach

NASA Astrophysics Data System (ADS)

Bellas-Velidis, Ioannis; Kontizas, Mary; Dapergolas, Anastasios; Livanou, Evdokia; Kontizas, Evangelos; Karampelas, Antonios

A software package Unresolved Galaxy Classifier (UGC) is being developed for the ground-based pipeline of ESA's Gaia mission. It aims to provide an automated taxonomic classification and specific parameters estimation analyzing Gaia BP/RP instrument low-dispersion spectra of unresolved galaxies. The UGC algorithm is based on a supervised learning technique, the Support Vector Machines (SVM). The software is implemented in Java as two separate modules. An offline learning module provides functions for SVM-models training. Once trained, the set of models can be repeatedly applied to unknown galaxy spectra by the pipeline's application module. A library of galaxy models synthetic spectra, simulated for the BP/RP instrument, is used to train and test the modules. Science tests show a very good classification performance of UGC and relatively good regression performance, except for some of the parameters. Possible approaches to improve the performance are discussed.

Radio supernovae and super star clusters in the circumnuclear region of NGC 1365

NASA Astrophysics Data System (ADS)

Lindblad, P. O.; Kristen, H.

Groundbased optical and VLA observations have shown that the nucleus of the barred Seyfert 1 galaxy NGC 1365 is surrounded by a number of star forming regions, or "hot spots", as well as a number of resolved and unresolved continuum radio sources. HST/FOC observations reveal that the nucleus is surrounded by a ring of very compact unresolved sources of the kind that have been discovered in a number of other galaxies, and that have been assumed to be very compact young globular star clusters. The hot spots are resolved into groups of such compact sources. VLA observations at lambda = 2 cm, where the resolution approaches that of HST, reveals that the brightest unresolved radio source at 2 cm, which has been assumed to be a radio supernova, coincides with one of the compact HST sources. The implications of this will be discussed.

Using GC×GC-ToF-MS to characterise SVOC from diesel exhaust emissions

NASA Astrophysics Data System (ADS)

Alam, M. S.; Ramadhas, A. S.; Stark, C. P.; Liu, D.; Xu, H.; Harrison, R. M.

2014-12-01

Despite intensive research over the last 20 years, a number of major research questions remain concerning the sources and properties of road traffic-generated particulate matter. There are major knowledge gaps concerning the composition of primary vehicle exhaust aerosol, and its contribution to secondary organic aerosol (SOA) formation. These uncertainties relate especially to the semi-volatile component of the particles. Semi-Volatile Organic Compounds (SVOC) are compounds which partition directly between the gas and aerosol phases under ambient conditions, and include compounds with saturation concentrations roughly between 0.1 and 104 μg m-3. The SVOC in engine exhaust are typically hydrocarbons in the C15-C35 range. They are largely uncharacterised, other than the n-alkanes, because they are unresolved by traditional gas chromatography and form a large hump in the chromatogram referred to as Unresolved Complex Mixture (UCM). In this study, samples were collected from the exhaust of a diesel engine with and without abatement devices fitted. Engine exhaust was diluted with air and collected using both filter and impaction (MOUDI), to resolve total mass and size resolved mass respectively. Particle size distribution was evaluated by sampling simultaneously with a Scanning Mobility Particle Sizer (SMPS). 2D Gas-Chromatography Time-of-Flight Mass-Spectrometry (GC×GC-ToF-MS) was exploited to characterise and quantify the composition of SVOC from the exhaust emission. The SVOC was observed to contain predominantly n-alkanes, alkyl-cyclohexanes and aromatics; similar to both fresh lubricating oil and fuel. Preliminary results indicate that the contribution of diesel fuel to the exhaust SVOC composition is dominant at high speeds, and a more pronounced contribution from lubricating oil is observed at low speeds. Differences were also observed in the SVOC composition when using different fuel types, engine lubricants, starting temperatures and collecting samples with and without abatement devices fitted. The wealth of compounds identified and quantified in the C15-C35 range included PAH, esters, carboxylic acids, alkanes, alkenes, alcohols and hopanes.

An evaluation of independent consumer assistance centers on problem resolution and user satisfaction: the consumer perspective.

PubMed

Nascimento, Lori Miller; Cousineau, Michael R

2005-04-01

Individuals who wish to receive independent assistance to resolve access to care health problems have limited options. The Health Consumer Alliance (HCA) is an independent, coordinated effort of nine legal services organizations that provide free assistance to low-income health consumers in 10 California counties. The need for the HCA stems from the vast number of health consumers with unanswered questions and unresolved problems relating to access to care issues, among both insured and uninsured populations. However, little is known about the effectiveness of independent consumer assistance centers. This paper examines the effectiveness of a network of independent consumer assistance programs in resolving consumer problems and consumers' level of satisfaction with services received. As the project evaluators, we conducted telephone surveys with 1,291 users of the HCA to assess if this independent program resolved consumer problems, and to measure the level of satisfaction among HCA users. Specifically, we asked questions about the HCA's influence on problem resolution, consumer satisfaction, health insurance status and use of preventive care services. From 1997 to 2001, more than 46,000 consumers contacted the seven health consumer centers (HCCs). According to our sample of respondents, results show that the HCCs are an important resource for low-income Californians trying to access health care. After contacting the HCCs, 62 percent of the participants report that their problems were resolved. In addition, 87 percent of the participants said the HCCs were helpful and 95 percent said they would be likely to contact the HCC again if necessary.

Critical evaluation of measured line positions of 14N16O in X2П state

NASA Astrophysics Data System (ADS)

Sulakshina, O. N.; Borkov, Yu. G.

2018-04-01

All available line positions for unresolved and resolved Λ-doublets of the 14N16O molecule in the X2 П state were collected from the literature and tested using the RITZ computer code. These data have been critically analysed and used to obtain the most complete set of 1789 experimental energy levels of unresolved Λ-doublets covering the 0-35,866 cm-1 interval. A set of 425 experimental energy levels of resolved Λ-doublets covering the 0-5957 cm-1 interval for two states 2П1/2 and 2П3/2 also have been obtained. These levels together with calculated correlation matrix can be used to generate the precise list of transitions with confidence intervals. Comparisons with the HITRAN as well as with Amiot calculations are discussed. The systematic shift between experimental energy levels of unresolved Λ-doublets and those calculated by Amiot for 2П3/2 state was found. The same systematic shift for transitions frequencies of unresolved Λ-doublets in forbidden subbands 2П1/2↔2П3/2 is also established in the HITRAN database. Comparison of the RITZ energy levels with calculated energy levels by Wong at al. was also done. It was found, that experimental RITZ energy levels for resolved Λ-doublets of 14N16O coincide with those calculated by Wong at al. within experimental uncertainties.

Broadband ion mobility deconvolution for rapid analysis of complex mixtures.

PubMed

Pettit, Michael E; Brantley, Matthew R; Donnarumma, Fabrizio; Murray, Kermit K; Solouki, Touradj

2018-05-04

High resolving power ion mobility (IM) allows for accurate characterization of complex mixtures in high-throughput IM mass spectrometry (IM-MS) experiments. We previously demonstrated that pure component IM-MS data can be extracted from IM unresolved post-IM/collision-induced dissociation (CID) MS data using automated ion mobility deconvolution (AIMD) software [Matthew Brantley, Behrooz Zekavat, Brett Harper, Rachel Mason, and Touradj Solouki, J. Am. Soc. Mass Spectrom., 2014, 25, 1810-1819]. In our previous reports, we utilized a quadrupole ion filter for m/z-isolation of IM unresolved monoisotopic species prior to post-IM/CID MS. Here, we utilize a broadband IM-MS deconvolution strategy to remove the m/z-isolation requirement for successful deconvolution of IM unresolved peaks. Broadband data collection has throughput and multiplexing advantages; hence, elimination of the ion isolation step reduces experimental run times and thus expands the applicability of AIMD to high-throughput bottom-up proteomics. We demonstrate broadband IM-MS deconvolution of two separate and unrelated pairs of IM unresolved isomers (viz., a pair of isomeric hexapeptides and a pair of isomeric trisaccharides) in a simulated complex mixture. Moreover, we show that broadband IM-MS deconvolution improves high-throughput bottom-up characterization of a proteolytic digest of rat brain tissue. To our knowledge, this manuscript is the first to report successful deconvolution of pure component IM and MS data from an IM-assisted data-independent analysis (DIA) or HDMSE dataset.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sidler, Rolf, E-mail: rsidler@gmail.com; Carcione, José M.; Holliger, Klaus

We present a novel numerical approach for the comprehensive, flexible, and accurate simulation of poro-elastic wave propagation in 2D polar coordinates. An important application of this method and its extensions will be the modeling of complex seismic wave phenomena in fluid-filled boreholes, which represents a major, and as of yet largely unresolved, computational problem in exploration geophysics. In view of this, we consider a numerical mesh, which can be arbitrarily heterogeneous, consisting of two or more concentric rings representing the fluid in the center and the surrounding porous medium. The spatial discretization is based on a Chebyshev expansion in themore » radial direction and a Fourier expansion in the azimuthal direction and a Runge–Kutta integration scheme for the time evolution. A domain decomposition method is used to match the fluid–solid boundary conditions based on the method of characteristics. This multi-domain approach allows for significant reductions of the number of grid points in the azimuthal direction for the inner grid domain and thus for corresponding increases of the time step and enhancements of computational efficiency. The viability and accuracy of the proposed method has been rigorously tested and verified through comparisons with analytical solutions as well as with the results obtained with a corresponding, previously published, and independently benchmarked solution for 2D Cartesian coordinates. Finally, the proposed numerical solution also satisfies the reciprocity theorem, which indicates that the inherent singularity associated with the origin of the polar coordinate system is adequately handled.« less

Blockade of neuronal dopamine D2 receptor attenuates morphine tolerance in mice spinal cord.

PubMed

Dai, Wen-Ling; Xiong, Feng; Yan, Bing; Cao, Zheng-Yu; Liu, Wen-Tao; Liu, Ji-Hua; Yu, Bo-Yang

2016-12-22

Tolerance induced by morphine remains a major unresolved problem and significantly limits its clinical use. Recent evidences have indicated that dopamine D2 receptor (D2DR) is likely to be involved in morphine-induced antinociceptive tolerance. However, its exact effect and molecular mechanism remain unknown. In this study we examined the effect of D2DR on morphine antinociceptive tolerance in mice spinal cord. Chronic morphine treatment significantly increased levels of D2DR in mice spinal dorsal horn. And the immunoreactivity of D2DR was newly expressed in neurons rather than astrocytes or microglia both in vivo and in vitro. Blockade of D2DR with its antagonist (sulpiride and L-741,626, i.t.) attenuated morphine antinociceptive tolerance without affecting basal pain perception. Sulpiride (i.t.) also down-regulated the expression of phosphorylation of NR1, PKC, MAPKs and suppressed the activation of astrocytes and microglia induced by chronic morphine administration. Particularly, D2DR was found to interact with μ opioid receptor (MOR) in neurons, and chronic morphine treatment enhanced the MOR/D2DR interactions. Sulpiride (i.t.) could disrupt the MOR/D2DR interactions and attenuate morphine tolerance, indicating that neuronal D2DR in the spinal cord may be involved in morphine tolerance possibly by interacting with MOR. These results may present new opportunities for the treatment and management of morphine-induced antinociceptive tolerance which often observed in clinic.

WholePathwayScope: a comprehensive pathway-based analysis tool for high-throughput data

PubMed Central

Yi, Ming; Horton, Jay D; Cohen, Jonathan C; Hobbs, Helen H; Stephens, Robert M

2006-01-01

Background Analysis of High Throughput (HTP) Data such as microarray and proteomics data has provided a powerful methodology to study patterns of gene regulation at genome scale. A major unresolved problem in the post-genomic era is to assemble the large amounts of data generated into a meaningful biological context. We have developed a comprehensive software tool, WholePathwayScope (WPS), for deriving biological insights from analysis of HTP data. Result WPS extracts gene lists with shared biological themes through color cue templates. WPS statistically evaluates global functional category enrichment of gene lists and pathway-level pattern enrichment of data. WPS incorporates well-known biological pathways from KEGG (Kyoto Encyclopedia of Genes and Genomes) and Biocarta, GO (Gene Ontology) terms as well as user-defined pathways or relevant gene clusters or groups, and explores gene-term relationships within the derived gene-term association networks (GTANs). WPS simultaneously compares multiple datasets within biological contexts either as pathways or as association networks. WPS also integrates Genetic Association Database and Partial MedGene Database for disease-association information. We have used this program to analyze and compare microarray and proteomics datasets derived from a variety of biological systems. Application examples demonstrated the capacity of WPS to significantly facilitate the analysis of HTP data for integrative discovery. Conclusion This tool represents a pathway-based platform for discovery integration to maximize analysis power. The tool is freely available at . PMID:16423281

CKD.QLD: establishment of a chronic kidney disease [CKD] registry in Queensland, Australia.

PubMed

Venuthurupalli, Sree K; Hoy, Wendy E; Healy, Helen G; Cameron, Anne; Fassett, Robert G

2017-06-07

Chronic kidney disease [CKD] is recognised as a global public health problem. Until recently, the majority of information informing on CKD has been generated from renal registries reporting on patients with end-stage kidney disease [ESKD] and on renal replacement therapy [RRT]. There has been a paucity of information on pre-dialysis CKD cohorts, and many issues related to these poorly described populations are unresolved. To this end, international organizations have called for CKD surveillance systems across all countries. In Australia, we have responded by developing the Chronic Kidney Disease in Queensland [CKD.QLD] with three main platforms consisting of CKD Registry, clinical trials and development of biobank. This registry which is the core component of CKD surveillance was conceptualized specifically for the pre-dialysis population in the public health system in Queensland, Australia. Recruitment started in May 2011, and to date the Registry has evolved as one of the largest CKD cohorts in the world with recruitment close to 7000 patients. The Registry has had many outcomes, including being the nidus for Australia's first National Health and Medical Research Council [NHMRC] CKD Centre of Research Excellence [CKD.CRE]. The Registry, with its linkage to Queensland Health datasets, is reporting, and is expected to continue generating, significant information on multiple aspects of CKD, its trajectory, management and patient outcomes. Intent of the CKD.CRE is to facilitate an expanded Registry network that has representation from health services, both public and private, across Australia.

An evaluation of rural health care research.

PubMed

Kane, R; Dean, M; Solomon, M

1979-05-01

Reviews the state of the art of rural health research and evaluation in the U.S. with particular emphasis on the questions of access, health personnel, and financing. The current state of knowledge both in the published and unpublished literature in each area is summarized and a series of unresolved issues is proposed. A strategy for further research to include the various types of rural health care programs is described. Major findings suggest that, although rural populations do have somewhat less access to care than do urban populations, our ability to quantify precisely the extent and importance of this discrepancy is underdeveloped. Despite a substantial investment in a variety of rural health care programs there is inadequate information as to their effectiveness. Programs designed to increase the supply of health personnel to rural areas have met with mixed success. Sites staffed by National Health Service Corps personnel show consistently lower productivity than do sites under other sponsorship. Nonphysician personnel (physician assistants and nurse practitioners) offer a promising source of primary care for rural areas: recent legislation that reimburses such care should increase their utilization. A persistent problem is the expectation (often a mandate) incorporated into many rural health care demonstration efforts that the programs become financially self-sufficient in a finite period of time. Self-sufficiency is a function of utilization, productivity, and the ability to recover charges for services. In many instances stringent enforcement of the self-sufficiency requirement may mean those who need services most will be least likely to receive them.

A plastid gene phylogeny of the non-photosynthetic parasitic Orobanche (Orobanchaceae) and related genera

USGS Publications Warehouse

Park, J.-M.; Manen, J.-F.; Colwell, A.E.; Schneeweiss, G.M.

2008-01-01

The phylogenetic relationships of the non-photosynthetic Orobanche sensu lato (Orobanchaceae), which includes some of the economically most important parasitic weeds, remain insufficiently understood and controversial. This concerns both the phylogenetic relationships within the genus, in particular its monophyly or lack thereof, and the relationships to other holoparasitic genera such as Cistanche or Conopholis. Here we present the first comprehensive phylogenetic study of this group based on a region from the plastid genome (rps2 gene). Although substitution rates appear to be elevated compared to the photosynthetic members of Orobanchaceae, relationships among the major lineages Cistanche, Conopholis plus Epifagus, Boschniakia rossica (Cham. & Schltdl.) B. Fedtsch., B. himalaica Hook. f. & Thomson, B. hookeri Walp. plus B. strobilacea A. Gray, and Orobanche s. l. remain unresolved. Resolution within Orobanche, however, is much better. In agreement with morphological, cytological and other molecular phylogenetic evidence, five lineages, corresponding to the four traditionally recognised sections (Gymnocaulis, Myzorrhiza, Orobanche, Trionychon) and O. latisquama Reut. ex Boiss. (of sect. Orobanche), can be distinguished. A combined analysis of plastid rps2 and nuclear ITS sequences of the holoparasitic genera results in more resolved and better supported trees, although the relationships among Orobanche s. l., Cistanche, and the clade including the remaining genera is unresolved. Therefore, rps2 is a marker from the plastid genome that is well-suited to be used in combination with other already established nuclear markers for resolving generic relationships of Orobanche and related genera. ?? 2008 The Botanical Society of Japan and Springer.

The enigma of the apparent disappearance of Eurasian highly pathogenic H5 clade 2.3.4.4 influenza A viruses in North American waterfowl

PubMed Central

Krauss, Scott; Stallknecht, David E.; Slemons, Richard D.; Bowman, Andrew S.; Poulson, Rebecca L.; Nolting, Jacqueline M.; Knowles, James P.; Webster, Robert G.

2016-01-01

One of the major unresolved questions in influenza A virus (IAV) ecology is exemplified by the apparent disappearance of highly pathogenic (HP) H5N1, H5N2, and H5N8 (H5Nx) viruses containing the Eurasian hemagglutinin 2.3.4.4 clade from wild bird populations in North America. The introduction of Eurasian lineage HP H5 clade 2.3.4.4 H5N8 IAV and subsequent reassortment with low-pathogenic H?N2 and H?N1 North American wild bird-origin IAVs in late 2014 resulted in widespread HP H5Nx IAV infections and outbreaks in poultry and wild birds across two-thirds of North America starting in November 2014 and continuing through June 2015. Although the stamping out strategies adopted by the poultry industry and animal health authorities in Canada and the United States—which included culling, quarantining, increased biosecurity, and abstention from vaccine use—were successful in eradicating the HP H5Nx viruses from poultry, these activities do not explain the apparent disappearance of these viruses from migratory waterfowl. Here we examine current and historical aquatic bird IAV surveillance and outbreaks of HP H5Nx in poultry in the United States and Canada, providing additional evidence of unresolved mechanisms that restrict the emergence and perpetuation of HP avian influenza viruses in these natural reservoirs. PMID:27457948

Composition and major sources of organic compounds in urban aerosols

NASA Astrophysics Data System (ADS)

Bi, Xinhui; Simoneit, Bernd R. T.; Sheng, Guoying; Ma, Shexia; Fu, Jiamo

Total suspended particles (TSP), collected during June 2002 to July 2003 in Guangzhou, a typical economically developed city in South China, were analyzed for the organic compound compositions using gas chromatography-mass spectrometry (GC/MS). Over 140 organic compounds were detected in the aerosols and grouped into different classes including n-alkanes, hopanoids, polycyclic aromatic hydrocarbons, alkanols, fatty acids, dicarboxylic acids excluding oxalic acid, polyols/polyacids, lignin products, phytosterols, phthalates and water-soluble sugars. The total amounts of the identified organic compounds including unresolved complex mixture (UCM) ranged from 3112 ng/m 3 in spring to 5116 ng/m 3 in winter, comprising on seasonal average 2.8% of TSP. Primary organic compounds peaked in winter although there are no heating systems burning fuels in Guangzhou. The highest saccharide levels occurred in fall due to agricultural activities. This study demonstrated that utilization of fossil fuels, biomass burning, soil resuspension and plastic/refuse burning are the major contributors to the identified organic compounds in the urban atmosphere of South China.

Global migration of influenza A viruses in swine

PubMed Central

Nelson, Martha I.; Viboud, Cécile; Vincent, Amy L.; Culhane, Marie R.; Detmer, Susan E.; Wentworth, David E.; Rambaut, Andrew; Suchard, Marc A.; Holmes, Edward C.; Lemey, Philippe

2015-01-01

The complex and unresolved evolutionary origins of the 2009 H1N1 influenza pandemic exposed major gaps in our knowledge of the global spatial ecology and evolution of influenza A viruses in swine (swIAVs). Here we undertake an expansive phylogenetic analysis of swIAV sequence data and demonstrate that the global live swine trade strongly predicts the spatial dissemination of swIAVs, with Europe and North America acting as sources of viruses in Asian countries. In contrast, China has the world’s largest swine population but is not a major exporter of live swine, and is not an important source of swIAVs in neighboring Asian countries or globally. A meta-population simulation model incorporating trade data predicts that the global ecology of swIAVs is more complex than previously thought, and the US and China’s large swine populations are unlikely to be representative of swIAV diversity in their respective geographic regions, requiring independent surveillance efforts throughout Latin America and Asia. PMID:25813399

Unresolved issues in the management of chronic stable angina.

PubMed

Camm, A John; Manolis, Athanasios; Ambrosio, Giuseppe; Daly, Caroline; Komajda, Michel; Lopez de Sa, Esteban; Lopez-Sendon, Jose Luis; Mugelli, Alessandro; Muggli, Franco; Tamargo, Juan

2015-12-15

Chronic stable angina is a common and progressive disease which has a major impact on patient quality of life and imposes a high financial and medical burden on society. Given the range of agents now available, optimal medical therapy - which according to guidelines is the preferred option in the majority of patients with low-risk disease - offers the opportunity for effective control. However, recent studies suggest that management remains suboptimal in up to a third of patients and that physicians often underestimate the extent to which angina continues to limit patients' lives. A higher frequency of angina also relates directly to increased healthcare costs. These factors suggest the need for the development and implementation of appropriate guidelines, for tools to encourage the regular, systematic assessment of the management of chronic stable angina patients, and for improved means of communication between doctors and patients. Neither physicians nor their patients need to accept that a certain level of angina symptoms is unavoidable. Copyright © 2015. Published by Elsevier Ireland Ltd.

Integration of collinear-type doubly unresolved counterterms in NNLO jet cross sections

NASA Astrophysics Data System (ADS)

Del Duca, Vittorio; Somogyi, Gábor; Trócsányi, Zoltán

2013-06-01

In the context of a subtraction method for jet cross sections at NNLO accuracy in the strong coupling, we perform the integration over the two-particle factorised phase space of the collinear-type contributions to the doubly unresolved counterterms. We present the final result as a convolution in colour space of the Born cross section and of an insertion operator, which is written in terms of master integrals that we expand in the dimensional regularisation parameter.

A subtraction scheme for computing QCD jet cross sections at NNLO: integrating the subtraction terms I

NASA Astrophysics Data System (ADS)

Somogyi, Gábor; Trócsányi, Zoltán

2008-08-01

In previous articles we outlined a subtraction scheme for regularizing doubly-real emission and real-virtual emission in next-to-next-to-leading order (NNLO) calculations of jet cross sections in electron-positron annihilation. In order to find the NNLO correction these subtraction terms have to be integrated over the factorized unresolved phase space and combined with the two-loop corrections. In this paper we perform the integration of all one-parton unresolved subtraction terms.

A subtraction scheme for computing QCD jet cross sections at NNLO: integrating the doubly unresolved subtraction terms

NASA Astrophysics Data System (ADS)

Somogyi, Gábor

2013-04-01

We finish the definition of a subtraction scheme for computing NNLO corrections to QCD jet cross sections. In particular, we perform the integration of the soft-type contributions to the doubly unresolved counterterms via the method of Mellin-Barnes representations. With these final ingredients in place, the definition of the scheme is complete and the computation of fully differential rates for electron-positron annihilation into two and three jets at NNLO accuracy becomes feasible.

Engineering microbial electrocatalysis for chemical and fuel production.

PubMed

Rosenbaum, Miriam A; Henrich, Alexander W

2014-10-01

In many biotechnological areas, metabolic engineering and synthetic biology have become core technologies for biocatalyst development. Microbial electrocatalysis for biochemical and fuel production is still in its infancy and reactions rates and the product spectrum are currently very low. Therefore, molecular engineering strategies will be crucial for the advancement and realization of many new bioproduction routes using electroactive microorganisms. The complex and unresolved biochemistry and physiology of extracellular electron transfer and the lack of molecular tools for these new non-model hosts for genetic engineering constitute the major challenges for this effort. This review is providing an insight into the current status, challenges and promising approaches of pathway engineering for microbial electrocatalysis. Copyright © 2014 Elsevier Ltd. All rights reserved.

CRISPR-Cas adaptation: insights into the mechanism of action.

PubMed

Amitai, Gil; Sorek, Rotem

2016-02-01

Since the first demonstration that CRISPR-Cas systems provide bacteria and archaea with adaptive immunity against phages and plasmids, numerous studies have yielded key insights into the molecular mechanisms governing how these systems attack and degrade foreign DNA. However, the molecular mechanisms underlying the adaptation stage, in which new immunological memory is formed, have until recently represented a major unresolved question. In this Progress article, we discuss recent discoveries that have shown both how foreign DNA is identified by the CRISPR-Cas adaptation machinery and the molecular basis for its integration into the chromosome to form an immunological memory. Furthermore, we describe the roles of each of the specific CRISPR-Cas components that are involved in memory formation, and consider current models for their evolutionary origin.

OBSERVED ASTEROID SURFACE AREA IN THE THERMAL INFRARED

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nugent, C. R.; Mainzer, A.; Masiero, J.

The rapid accumulation of thermal infrared observations and shape models of asteroids has led to increased interest in thermophysical modeling. Most of these infrared observations are unresolved. We consider what fraction of an asteroid’s surface area contributes the bulk of the emitted thermal flux for two model asteroids of different shapes over a range of thermal parameters. The resulting observed surface in the infrared is generally more fragmented than the area observed in visible wavelengths, indicating high sensitivity to shape. For objects with low values of the thermal parameter, small fractions of the surface contribute the majority of thermally emittedmore » flux. Calculating observed areas could enable the production of spatially resolved thermal inertia maps from non-resolved observations of asteroids.« less

Triglyceride Treatment in the Age of Cholesterol Reduction

PubMed Central

Agrawal, Nidhi; Corradi, Patricia Freitas; Gumaste, Namrata; Goldberg, Ira J.

2017-01-01

Cholesterol reduction has markedly reduced major cardiovascular disease (CVD) events and shown regression of atherosclerosis in some studies. However, CVD has for decades also been associated with increased levels of circulating triglyceride (TG)-rich lipoproteins. Whether this is due to a direct toxic effect of these lipoproteins on arteries or whether this is merely an association is unresolved. More recent genetic analyses have linked genes that modulate TG metabolism with CVD. Moreover, analyses of subgroups of hypertriglyceridemic (HTG) subjects in clinical trials using fibric acid drugs have been interpreted as evidence that TG reduction reduces CVD events. This review will focus on how HTG might cause CVD, whether TG reduction makes a difference, what pathophysiological defects cause HTG, and what options are available for treatment. PMID:27544319

Evidence-based disease management: its role in cardiovascular risk reduction.

PubMed

Fanning, Etta L

2004-01-01

Cardiovascular disease remains the most pressing healthcare problem in the United States. Traditional risk factors--hypertension, obesity, and diabetes-are still unresolved issues; and new risk factors--pre-diabetes, insulin resistance, and pediatric and adolescent diabetes-have emerged. There is an urgent need to identify the risk factors for cardiovascular disease, and address risk reduction with disease management and treatment for each factor, based on qualitative and quantitative approaches for developing the evidence base for public health action. The objectives of this paper are to review (i) the burden of cardiovascular illness-morbidity, mortality, and cost; (ii) risk factors and the emerging epidemic of adolescent obesity; (iii) the challenges of attaining target endpoints; and (iv) the attributes of a successful programmatic healthcare initiative for potential impact on cardiovascular care and, eventually, public health.

Syndromes associated with Homo sapiens pol II regulatory genes.

PubMed

Bina, M; Demmon, S; Pares-Matos, E I

2000-01-01

The molecular basis of human characteristics is an intriguing but an unresolved problem. Human characteristics cover a broad spectrum, from the obvious to the abstract. Obvious characteristics may include morphological features such as height, shape, and facial form. Abstract characteristics may be hidden in processes that are controlled by hormones and the human brain. In this review we examine exaggerated characteristics presented as syndromes. Specifically, we focus on human genes that encode transcription factors to examine morphological, immunological, and hormonal anomalies that result from deletion, insertion, or mutation of genes that regulate transcription by RNA polymerase II (the Pol II genes). A close analysis of abnormal phenotypes can give clues into how sequence variations in regulatory genes and changes in transcriptional control may give rise to characteristics defined as complex traits.

Witnessing violence: making the invisible visible.

PubMed

Holton, J K

1995-01-01

In his novel of Black life circa the 1950s, Invisible Man, Ralph Ellison laid bare the wasteful, destructive societal consequences of racism. At the close of the 20th century, we are faced with the phenomenon of another social problem, likewise unresolved and likely to haunt us similarly: urban violence. Following Ellison's example, this paper seeks to explore the impact of violence's stark invisibility by discussing a research strategy that better explains the terrifying phenomenon of violence. In order to comprehend the totality of violence, macro- and micro-level variables have to be introduced into the research design and measured over time. Therefore, research might best address violence if it was designed to include variables of poverty and racism, and was more inclusive of research from a broader range of scientific disciplines.

Neurocysticercosis: Diagnostic problems & current therapeutic strategies

PubMed Central

Rajshekhar, Vedantam

2016-01-01

Neurocysticercosis (NCC) is the most common single cause of seizures/epilepsy in India and several other endemic countries throughout the world. It is also the most common parasitic disease of the brain caused by the cestode Taenia solium or pork tapeworm. The diagnosis of NCC and the tapeworm carrier (taeniasis) can be relatively inaccessible and expensive for most of the patients. In spite of the introduction of several new immunological tests, neuroimaging remains the main diagnostic test for NCC. The treatment of NCC is also mired in controversy although, there is emerging evidence that albendazole (a cysticidal drug) may be beneficial for patients by reducing the number of seizures and hastening the resolution of live cysts. Currently, there are several diagnostic and management issues which remain unresolved. This review will highlight some of these issues. PMID:28139530

Simulation of modern climate with the new version of the INM RAS climate model

NASA Astrophysics Data System (ADS)

Volodin, E. M.; Mortikov, E. V.; Kostrykin, S. V.; Galin, V. Ya.; Lykosov, V. N.; Gritsun, A. S.; Diansky, N. A.; Gusev, A. V.; Yakovlev, N. G.

2017-03-01

The INMCM5.0 numerical model of the Earth's climate system is presented, which is an evolution from the previous version, INMCM4.0. A higher vertical resolution for the stratosphere is applied in the atmospheric block. Also, we raised the upper boundary of the calculating area, added the aerosol block, modified parameterization of clouds and condensation, and increased the horizontal resolution in the ocean block. The program implementation of the model was also updated. We consider the simulation of the current climate using the new version of the model. Attention is focused on reducing systematic errors as compared to the previous version, reproducing phenomena that could not be simulated correctly in the previous version, and modeling the problems that remain unresolved.

REVIEWS OF TOPICAL PROBLEMS: Acceleration of cosmic rays by shock waves

NASA Astrophysics Data System (ADS)

Berezhko, E. G.; Krymskiĭ, G. F.

1988-01-01

Theoretical work on various processes by which shock waves accelerate cosmic rays is reviewed. The most efficient of these processes, Fermi acceleration, is singled out for special attention. A linear theory for this process is presented. The results found on the basis of nonlinear models of Fermi acceleration, which incorporate the modification of the structure caused by the accelerated particles, are reported. There is a discussion of various possibilities for explaining the generation of high-energy particles observed in interplanetary and interstellar space on the basis of a Fermi acceleration mechanism. The acceleration by shock waves from supernova explosions is discussed as a possible source of galactic cosmic rays. The most important unresolved questions in the theory of acceleration of charged particles by shock waves are pointed out.

Against the integrative turn in bioethics: burdens of understanding.

PubMed

Savić, Lovro; Ivanković, Viktor

2018-06-01

The advocates of Integrative Bioethics have insisted that this recently emerging project aspires to become a new stage of bioethical development, surpassing both biomedically oriented bioethics and global bioethics. We claim in this paper that if the project wants to successfully replace the two existing paradigms, it at least needs to properly address and surmount the lack of common moral vocabulary problem. This problem points to a semantic incommensurability due to cross-language communication in moral terms. This paper proceeds as follows. In the first part, we provide an overview of Integrative Bioethics and its conceptual building blocks: mutlidisciplinarity, interdisciplinarity, and transdisciplinarity. In the second part, we disclose the problem of semantic incommensurability. The third part gives an overview of various positions on the understanding of interdisciplinarity and integration in interdisciplinary communication, and corresponding attempts at solving the lack of common moral vocabulary problem. Here we lean mostly on Holbrook's three theses regarding the character of interdisciplinary communication. Finally, in the fourth part, we discuss a particular bioethical case-that of euthanasia-to demonstrate the challenge semantic incommensurability poses to dialogues in Integrative Bioethics. We conclude that Integrative Bioethics does not offer a methodological toolset that would warrant optimism in its advocates' predictions of surpassing current modes of doing bioethics. Since Integrative Bioethics leaves controversial methodological questions unresolved on almost all counts and shows no attempts at overcoming the critical stumbling points, we argue for its rejection.

IUE and Einstein observations of the LINER galaxy NGC 4579

NASA Technical Reports Server (NTRS)

Reichert, G. A.; Puchnarewicz, E. M.; Mason, K. O.

1990-01-01

Results of International Ultraviolet Explorer (IUE) and Einstein observations of the LINER galaxy NGC 4579 are reported. Spatial profiles of the long wavelength IUE emission show a two component structure, with an unresolved core superimposed on broader underlying emission. The core spectrum shows strong C II lambda 2326 and broad Mg II lambda 2800 emission, and perhaps emission due to blends of Fe II multiplets (2300 to 23600 angstrom). The short wavelength emission is spatially unresolved, and shows C II lambda 1335, C III lambda 1909 broad C IV lambda 1550 emission, and a broad feature at approximately 1360 angstrom which may be due to 0.1 lambda 1356. Contrary to previous reports no evidence for He II lambda 1640 is found in the spectrum. An unresolved x ray source is detected at the location of the nucleus; its spectrum is well fitted by a power law of energy slope alpha approximately -0.5. These results further support the idea that NGC 4579 may contain a dwarf Seyfert nucleus.

Unfinished Business in Bereavement

PubMed Central

Klingspon, Kara L.; Holland, Jason M.; Neimeyer, Robert A.; Lichtenthal, Wendy G.

2016-01-01

Unfinished business (incomplete, unexpressed or unresolved relationship issues with the deceased) is frequently discussed as a risk factor for chronic and severe grief reactions. However, few empirical studies have examined this construct. The present study aimed to address this gap in the literature by examining the presence and severity of unfinished business as well as common themes of unfinished business reported in open-ended qualitative narratives among a sample of 224 bereaved individuals. In bivariate analyses, self-reported presence of unfinished business and the severity of distress due to unfinished business were both found to be associated with poorer bereavement outcomes. However, after controlling for potential confounds, distress related to unresolved issues with the deceased emerged as a more robust correlate of these outcomes. Qualitative responses were categorized, and the type of reported unfinished business was not significantly related to the degree of unfinished business distress or other bereavement outcomes. These findings provide preliminary justification for bereavement interventions that aim to ameliorate distress related to unresolved relational issues with the deceased. PMID:26057117

Unfinished Business in Bereavement.

PubMed

Klingspon, Kara L; Holland, Jason M; Neimeyer, Robert A; Lichtenthal, Wendy G

2015-01-01

Unfinished business (incomplete, unexpressed or unresolved relationship issues with the deceased) is frequently discussed as a risk factor for chronic and severe grief reactions. However, few empirical studies have examined this construct. The present study aimed to address this gap in the literature by examining the presence and severity of unfinished business as well as common themes of unfinished business reported in open-ended qualitative narratives among a sample of 224 bereaved individuals. In bivariate analyses, self-reported presence of unfinished business and the severity of distress due to unfinished business were both found to be associated with poorer bereavement outcomes. However, after controlling for potential confounds, distress related to unresolved issues with the deceased emerged as a more robust correlate of these outcomes. Qualitative responses were categorized, and the type of reported unfinished business was not significantly related to the degree of unfinished business distress or other bereavement outcomes. These findings provide preliminary justification for bereavement interventions that aim to ameliorate distress related to unresolved relational issues with the deceased.

Auxiliary-cavity-assisted ground-state cooling of an optically levitated nanosphere in the unresolved-sideband regime

NASA Astrophysics Data System (ADS)

Feng, Jin-Shan; Tan, Lei; Gu, Huai-Qiang; Liu, Wu-Ming

2017-12-01

We theoretically analyze the ground-state cooling of an optically levitated nanosphere in the unresolved-sideband regime by introducing a coupled high-quality-factor cavity. On account of the quantum interference stemming from the presence of the coupled cavity, the spectral density of the optical force exerting on the nanosphere gets changed and then the symmetry between the heating and the cooling processes is broken. Through adjusting the detuning of a strong-dissipative cavity mode, one obtains an enhanced net cooling rate for the nanosphere. It is illustrated that the ground-state cooling can be realized in the unresolved sideband regime even if the effective optomechanical coupling is weaker than the frequency of the nanosphere, which can be understood by the picture that the effective interplay of the nanosphere and the auxiliary cavity mode brings the system back to an effective resolved regime. Besides, the coupled cavity refines the dynamical stability of the system.

Perspectives on hypersonic viscous and nonequilibrium flow research

NASA Technical Reports Server (NTRS)

Cheng, H. K.

1992-01-01

An attempt is made to reflect on current focuses in certain areas of hypersonic flow research by examining recent works and their issues. Aspects of viscous interaction, flow instability, and nonequilibrium aerothermodynamics pertaining to theoretical interest are focused upon. The field is a diverse one, and many exciting works may have either escaped the writer's notice or been abandoned for the sake of space. Students of hypersonic viscous flow must face the transition problems towards the two opposite ends of the Reynolds or Knudsen number range, which represents two regimes where unresolved fluid/gas dynamic problems abound. Central to the hypersonic flow studies is high-temperature physical gas dynamics; here, a number of issues on modelling the intermolecular potentials and inelastic collisions remain the obstacles to quantitative predictions. Research in combustion and scramjet propulsion will certainly be benefitted by advances in turbulent mixing and new computational fluid dynamics (CFD) strategies on multi-scaled complex reactions. Even for the sake of theoretical development, the lack of pertinent experimental data in the right energy and density ranges is believed to be among the major obstacles to progress in aerothermodynamic research for hypersonic flight. To enable laboratory simulation of nonequilibrium effects anticipated for transatmospheric flight, facilities capable of generating high enthalpy flow at density levels higher than in existing laboratories are needed (Hornung 1988). A new free-piston shock tunnel capable of realizing a test-section stagnation temperature of 10(exp 5) at Reynolds number 50 x 10(exp 6)/cm is being completed and preliminary tests has begun (H. Hornung et al. 1992). Another laboratory study worthy of note as well as theoretical support is the nonequilibrium flow experiment of iodine vapor which has low activation energies for vibrational excitation and dissociation, and can be studied in a laboratory with modest resources (Pham-Van-Diep et al. 1992).

Unresolved subclinical hypothyroidism is independently associated with progression of chronic kidney disease.

PubMed

Kim, Eun Oh; Lee, Ihn Suk; Choi, Yoo A; Lee, Sang Ju; Chang, Yoon Kyung; Yoon, Hye Eun; Jang, Yi Sun; Lee, Jong Min; Kim, Hye Soo; Yang, Chul Woo; Kim, Suk Young; Hwang, Hyeon Seok

2014-01-01

Patients with chronic kidney disease (CKD) often have subclinical hypothyroidism. However, few reports have investigated changes in the status of subclinical hypothyroidism in CKD patients and its clinical significance in CKD progression. We included 168 patients with nondialysis-dependent CKD stages 2-4. The normalization of subclinical hypothyroidism during follow-up was assessed, and the association between transitions in subclinical hypothyroid status and the rate of decline of the estimated glomerular filtration rate (eGFR) was investigated. At baseline, 127 patients were euthyroid and 41 (24.4%) patients were diagnosed with subclinical hypothyroidism. Of these 41 patients, 21 (51.2%) spontaneously resolved to euthyroid during follow-up. The rate of eGFR decline of patients with resolved subclinical hypothyroidism was similar to that of euthyroid patients. The patients with unresolved subclinical hypothyroidism showed a steeper renal function decline than patients with euthyroidism or resolved subclinical hypothyroidism (all p < 0.05). The progression to end-stage renal disease was more frequent in those with unresolved subclinical hypothyroidism than in those who were euthyroid (p = 0.006). In multivariate linear regression for rate of eGFR decrease, unresolved subclinical hypothyroidism (β = -5.77, p = 0.001), baseline renal function (β = -0.12, p < 0.001) and level of proteinuria (β = -2.36, p = 0.015) were independently associated with the rate of renal function decline. Half of the CKD patients with subclinical hypothyroidism did not resolve to euthyroidism, and this lack of resolution was independently associated with rapid renal function decline.

Lipaemic donations: truth and consequences.

PubMed

Lippi, Giuseppe; Franchini, Massimo

2013-10-01

The problem of using material of unsuitable quality, including "nontransparent turbid milky plasma" or more simply "turbid plasma", for producing blood components is not trivial for several epidemiological, technical, analytical, clinical and economical reasons. With some exception, most national and international guidelines mandate that blood components should preferably not be produced from lipaemic donations. The origin of lipaemic blood is variegated, and includes physiological or paraphysiological causes and metabolic disorders, whereas a broad range of common diseases and drugs can also be associated with hypertriglyceridaemia. Overall, the frequency of lipaemic donations ranges between 0.31% and 0.35%, although sporadic reports have highlighted that the frequency might be much higher, up to 13%. Lipaemic donations pose two leading problems in transfusion medicine, that are interference during laboratory testing, and safety of producing blood components from hypertriglyceridaemic materials. While the former issue can be overcome by using chemical or mechanical methods, the clinical use of lipaemic blood for producing components remains an unresolved question. Transfusion medicine should thereby embark on a landmark effort to find a universal agreement of behaviours and harmonization of policies worldwide. Copyright © 2012 Elsevier Ltd. All rights reserved.

Rule extraction from minimal neural networks for credit card screening.

PubMed

Setiono, Rudy; Baesens, Bart; Mues, Christophe

2011-08-01

While feedforward neural networks have been widely accepted as effective tools for solving classification problems, the issue of finding the best network architecture remains unresolved, particularly so in real-world problem settings. We address this issue in the context of credit card screening, where it is important to not only find a neural network with good predictive performance but also one that facilitates a clear explanation of how it produces its predictions. We show that minimal neural networks with as few as one hidden unit provide good predictive accuracy, while having the added advantage of making it easier to generate concise and comprehensible classification rules for the user. To further reduce model size, a novel approach is suggested in which network connections from the input units to this hidden unit are removed by a very straightaway pruning procedure. In terms of predictive accuracy, both the minimized neural networks and the rule sets generated from them are shown to compare favorably with other neural network based classifiers. The rules generated from the minimized neural networks are concise and thus easier to validate in a real-life setting.

Anaxagoras and the Scientist/Laity Interaction

NASA Astrophysics Data System (ADS)

Woolf, N. J.

The phenomenon that caused Anaxagoras to develop his model that explained the phases and eclipses of the Moon was a meteorite fall. The model was a turning point for science in explaining more than one phenomenon with a single model. It precipitated the growth of Greek astronomy and the first heliocentric theory. Anaxagoras was also the first scientist to get into trouble for a conflict between science and religion. Contrary to an impression from the title of this conference, scientific literature paid little attention to the meteorite fall phenomenon. Both scientists and the public mainly pay attention to models, and often to the extraneous irrelevant attachments of models, those by which it is placed in memory. Models are artistic creations that are culture dependent. Phenomena are our only solid link to the world of reality. The main issue of this paper is the problems that the individual has with models. The paper discusses the effect of Anaxagoras on scientific thought. It concludes by exploring three areas where relationship of science to society as Anaxagoras set it up, has left unresolved problems.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Crowder, Jeff; Jet Propulsion Laboratory, California Institute of Technology, Pasadena, California 91109; Cornish, Neil J.

Low frequency gravitational wave detectors, such as the Laser Interferometer Space Antenna (LISA), will have to contend with large foregrounds produced by millions of compact galactic binaries in our galaxy. While these galactic signals are interesting in their own right, the unresolved component can obscure other sources. The science yield for the LISA mission can be improved if the brighter and more isolated foreground sources can be identified and regressed from the data. Since the signals overlap with one another, we are faced with a 'cocktail party' problem of picking out individual conversations in a crowded room. Here we presentmore » and implement an end-to-end solution to the galactic foreground problem that is able to resolve tens of thousands of sources from across the LISA band. Our algorithm employs a variant of the Markov chain Monte Carlo (MCMC) method, which we call the blocked annealed Metropolis-Hastings (BAM) algorithm. Following a description of the algorithm and its implementation, we give several examples ranging from searches for a single source to searches for hundreds of overlapping sources. Our examples include data sets from the first round of mock LISA data challenges.« less

Brain Tissue Oxygen Monitoring and the Intersection of Brain and Lung: A Comprehensive Review.

PubMed

Ngwenya, Laura B; Burke, John F; Manley, Geoffrey T

2016-09-01

Traumatic brain injury is a problem that affects millions of Americans yearly and for which there is no definitive treatment that improves outcome. Continuous brain tissue oxygen (PbtO2 ) monitoring is a complement to traditional brain monitoring techniques, such as intracranial pressure and cerebral perfusion pressure. PbtO2 monitoring has not yet become a clinical standard of care, due to several unresolved questions. In this review, we discuss the rationale and technology of PbtO2 monitoring. We review the literature, both historic and current, and show that continuous PbtO2 monitoring is feasible and useful in patient management. PbtO2 numbers reflect cerebral blood flow and oxygen diffusion. Thus, continuous monitoring of PbtO2 yields important information about both the brain and the lung. The preclinical and clinical studies demonstrating these findings are discussed. In this review, we demonstrate that patient management in a PbtO2 -directed fashion is not the sole answer to the problem of treating traumatic brain injury but is an important adjunct to the armamentarium of multimodal neuromonitoring. Copyright © 2016 by Daedalus Enterprises.

Nanocarriers as pulmonary drug delivery systems to treat and to diagnose respiratory and non respiratory diseases

PubMed Central

Smola, Malgorzata; Vandamme, Thierry; Sokolowski, Adam

2008-01-01

The purpose of this review is to discuss the impact of nanocarriers administered by pulmonary route to treat and to diagnose respiratory and non respiratory diseases. Indeed, during the past 10 years, the removal of chlorofluorocarbon propellants from industrial and household products intended for the pulmonary route has lead to the developments of new alternative products. Amongst these ones, on one hand, a lot of attention has been focused to improve the bioavailability of marketed drugs intended for respiratory diseases and to develop new concepts for pulmonary administration of drugs and, on the other hand, to use the pulmonary route to administer drugs for systemic diseases. This has led to some marketed products through the last decade. Although the introduction of nanotechnology permitted to step over numerous problems and to improve the bioavailability of drugs, there are, however, unresolved delivery problems to be still addressed. These scientific and industrial innovations and challenges are discussed along this review together with an analysis of the current situation concerning the industrial developments. PMID:18488412

[Gender identity disorder and related sexual behavior problems in children and adolescents: from the perspective of development and child psychiatry].

PubMed

Yamashita, Hiroshi

2013-01-01

The present paper reviews the theoretical and empirical literature on children and adolescents with gender identity disorder. The organizational framework underlying this review is one that presents gender behavior in children and adolescents as a continuum rather than as a dichotomy of normal versus abnormal categories. Theories of normative gender development, prevalence, assessment, developmental trajectories, and comorbidity were investigated. There is a greater fluidity and likelihood of change in the pre-pubertal period. It was reported that the majority of affected children had been eventually developing a homosexual orientation. As an approach to determine the prevalence of GID in clinical samples in our child psychiatry clinic, screening instruments that include items on cross-gender or cross-sex identification were used. We applied the Child Behavior Checklist (CBCL). Of the 113 items in the Japanese version of the CBCL, there are two measures of cross-gender identification: "behaves like opposite sex" and "wishes to be opposite sex." Like the other items, they are scored on a 3-point scale of: 0-not true, 1- somewhat true, and 2-very true. Our study of 323 clinically-referred children aged 4-15 years reported that, among the boys, 9.6% assigned a score of 1 (somewhat true) or a score of 2 (very true) to the two items. The corresponding rates for the clinically-referred girls were 24.5%. The item of diagnosis of GID in our clinical sample was significantly higher than in non-referred children, reported as 2-5% using the same method. Two clinical case histories of screened children are also presented. Both of them were diagnosed with PDDNOS. Together with the literature review, most of the gender-related symptoms in autistic spectrum disorders (ASD) could be related to the behavioral and psychological characteristics of autism as shown in case histories. ASD subjects in adolescence can sometimes develop a unique confusion of identity that occasionally exaggerates to gender-related problems. However, these views do not explain all cases; true comorbidity of ASD and GID should be considered. A full assessment including evaluation of the family, school, and social environment is essential as other emotional and behavioral problems are very common and unresolved issues in the child's environment are often present e. g., loss. Separation problems are particularly common in the younger group. Intervention should aim to assist development, particularly that of gender identity. It should focus on ameliorating the comorbid problems and difficulties in the child's life and reducing the distress experienced by the child.

[HPV immunization for the prevention of cervical cancer].

PubMed

Mougin, Christiane; Bourgault-Villada, Isabelle; Coursaget, Pierre

2009-12-01

Human Papillomaviruses (HPV) infect epithelial cells of the skin and mucosae. Mucosal high-risk HPV types (mainly HPV 16 and 18) are involved in the development of cervical cancer, one of the most common cancers in young women. HPV infection is usually asymptomatic and clears spontaneously, but 10 - 15 % of high-risk HPV infections are persistent and increase the risk of precancerous and cancerous lesions of the cervix. Two HPV vaccines have been licensed to provide protection against cervical cancer. To report the different aspects of HPV infection in order to improve the understanding of the particular problems of HPV vaccination and to review the most recent findings related to HPV vaccines, particularly regarding the protective efficacy of vaccines and the roles of adjuvants and immune response in protection. Articles were selected from the PubMed database (National Library of Medicine- National Institute of Health) with the following Keywords "HPV", "Prevention", "HPV vaccines", "Immune response", "Antibody". Abstracts of oral presentations from international meetings were also selected for the more recent findings. a critical analysis of the majority of papers published was undertaken and relevant information summarized. Virus-like particle production by expressing the major protein of the HPV capsid was carried out in the early 90's, leading to the recent development of two HPV vaccines. These vaccines are now licensed in many countries and have been demonstrated to be highly immunogenic. In subjects that are non-infected at the time of vaccination, HPV vaccines are highly effective in preventing persistent HPV 16 - 18 infections (90 %) and precursors lesions of cervical cancer associated with these two HPV types (close to 100 %). Clinical trials have also confirmed that HPV vaccines are well tolerated by recipients. The present paper is a detailed review published in French on HPV vaccines, their efficacy in the prevention of HPV infections and unresolved questions regarding the use of HPV vaccines. This report also includes biological and immunological information to improve the understanding of HPV vaccination.

Goals, dilemmas and assumptions in infant feeding education and support. Applying theory of constraints thinking tools to develop new priorities for action.

PubMed

Trickey, Heather; Newburn, Mary

2014-01-01

Three important infant feeding support problems are addressed: (1) mothers who use formula milk can feel undersupported and judged; (2) mothers can feel underprepared for problems with breastfeeding; and (3) many mothers who might benefit from breastfeeding support do not access help. Theory of constraints (TOC) is used to examine these problems in relation to ante-natal education and post-natal support. TOC suggests that long-standing unresolved problems or 'undesirable effects' in any system (in this case a system to provide education and support) are caused by conflicts, or dilemmas, within the system, which might not be explicitly acknowledged. Potential solutions are missed by failure to question assumptions which, when interrogated, often turn out to be invalid. Three core dilemmas relating to the three problems are identified, articulated and explored using TOC methodology. These are whether to: (1) promote feeding choice or to promote breastfeeding; (2) present breastfeeding positively, as straightforward and rewarding, or focus on preparing mothers for problems; and (3) offer support proactively or ensure that mothers themselves initiate requests for support. Assumptions are identified and interrogated, leading to clarified priorities for action relating to each problem. These are (1) shift the focus from initial decision-making towards support for mothers throughout their feeding journeys, enabling and protecting decisions to breastfeed as one aspect of ongoing support; (2) to promote the concept of an early-weeks investment and adjustment period during which breastfeeding is established; and (3) to develop more proactive mother-centred models of support for all forms of infant feeding. © 2012 John Wiley & Sons Ltd.

Parent-Adolescent Conflict as Sequences of Reciprocal Negative Emotion: Links with Conflict Resolution and Adolescents' Behavior Problems.

PubMed

Moed, Anat; Gershoff, Elizabeth T; Eisenberg, Nancy; Hofer, Claire; Losoya, Sandra; Spinrad, Tracy L; Liew, Jeffrey

2015-08-01

Although conflict is a normative part of parent-adolescent relationships, conflicts that are long or highly negative are likely to be detrimental to these relationships and to youths' development. In the present article, sequential analyses of data from 138 parent-adolescent dyads (adolescents' mean age was 13.44, SD = 1.16; 52 % girls, 79 % non-Hispanic White) were used to define conflicts as reciprocal exchanges of negative emotion observed while parents and adolescents were discussing "hot," conflictual issues. Dynamic components of these exchanges, including who started the conflicts, who ended them, and how long they lasted, were identified. Mediation analyses revealed that a high proportion of conflicts ended by adolescents was associated with longer conflicts, which in turn predicted perceptions of the "hot" issue as unresolved and adolescent behavior problems. The findings illustrate advantages of using sequential analysis to identify patterns of interactions and, with some certainty, obtain an estimate of the contingent relationship between a pattern of behavior and child and parental outcomes. These interaction patterns are discussed in terms of the roles that parents and children play when in conflict with each other, and the processes through which these roles affect conflict resolution and adolescents' behavior problems.

Integrating LPR with CCTV systems: problems and solutions

NASA Astrophysics Data System (ADS)

Bissessar, David; Gorodnichy, Dmitry O.

2011-06-01

A new generation of high-resolution surveillance cameras makes it possible to apply video processing and recognition techniques on live video feeds for the purpose of automatically detecting and identifying objects and events of interest. This paper addresses a particular application of detecting and identifying vehicles passing through a checkpoint. This application is of interest to border services agencies and is also related to many other applications. With many commercial automated License Plate Recognition (LPR) systems available on the market, some of which are available as a plug-in for surveillance systems, this application still poses many unresolved technological challenges, the main two of which are: i) multiple and often noisy license plate readings generated for the same vehicle, and ii) failure to detect a vehicle or license plate altogether when the license plate is occluded or not visible. This paper presents a solution to both of these problems. A data fusion technique based on the Levenshtein distance is used to resolve the first problem. An integration of a commercial LPR system with the in-house built Video Analytic Platform is used to solve the latter. The developed solution has been tested in field environments and has been shown to yield a substantial improvement over standard off-the-shelf LPR systems.

Watchers of the multiverse

DOE Office of Scientific and Technical Information (OSTI.GOV)

Garriga, Jaume; Vilenkin, Alexander, E-mail: jaume.garriga@ub.edu, E-mail: vilenkin@cosmos.phy.tufts.edu

2013-05-01

An unresolved question in inflationary cosmology is the assignment of probabilities to different types of events that can occur in the eternally inflating multiverse. We explore the possibility that the resolution of this ''measure problem'' may rely on non-standard dynamics in regions of high curvature. In particular, ''big crunch'' singularities at the future boundary of bubbles with negative vacuum energy density may lead to bounces, where contraction is replaced by inflationary expansion driven by different vacua in the landscape. Similarly, singularities inside of black holes might be gateways to other inflating vacua. This would drastically affect the global structure ofmore » the inflating multiverse. We consider a measure based on a probe geodesic which undergoes an infinite number of passages through crunches. This can be thought of as the world-line of an eternal ''watcher{sup ,} collecting data in an orderly fashion. We compare this to previous approaches to the measure problem. The watcher's measure is independent of initial conditions and does not suffer from ambiguities associated with the choice of a cut-off surface. Another potential benefit from passing through crunches is that the observations collected by the watcher may easily depart from ergodicity, in very generic landscapes. This may significantly alleviate the problem of Boltzmann Brain dominance.« less

G.A.M.E.: GPU-accelerated mixture elucidator.

PubMed

Schurz, Alioune; Su, Bo-Han; Tu, Yi-Shu; Lu, Tony Tsung-Yu; Lin, Olivia A; Tseng, Yufeng J

2017-09-15

GPU acceleration is useful in solving complex chemical information problems. Identifying unknown structures from the mass spectra of natural product mixtures has been a desirable yet unresolved issue in metabolomics. However, this elucidation process has been hampered by complex experimental data and the inability of instruments to completely separate different compounds. Fortunately, with current high-resolution mass spectrometry, one feasible strategy is to define this problem as extending a scaffold database with sidechains of different probabilities to match the high-resolution mass obtained from a high-resolution mass spectrum. By introducing a dynamic programming (DP) algorithm, it is possible to solve this NP-complete problem in pseudo-polynomial time. However, the running time of the DP algorithm grows by orders of magnitude as the number of mass decimal digits increases, thus limiting the boost in structural prediction capabilities. By harnessing the heavily parallel architecture of modern GPUs, we designed a "compute unified device architecture" (CUDA)-based GPU-accelerated mixture elucidator (G.A.M.E.) that considerably improves the performance of the DP, allowing up to five decimal digits for input mass data. As exemplified by four testing datasets with verified constitutions from natural products, G.A.M.E. allows for efficient and automatic structural elucidation of unknown mixtures for practical procedures. Graphical abstract .

How temperament and character affect our career, relationships, and mental health.

PubMed

Gutiérrez, Fernando; Gárriz, Miguel; Peri, Josep M; Vall, Gemma; Torrubia, Rafael

2016-10-01

On the way toward an agreed dimensional taxonomy for personality disorders (PD), several pivotal questions remain unresolved. We need to know which dimensions produce problems and in what domains of life; whether impairment can be found at one or both extremes of each dimension; and whether, as is increasingly advocated, some dimensions measure personality functioning whereas others reflect style. To gain this understanding, we administered the Temperament and Character Inventory to a sample of 862 consecutively attended outpatients, mainly with PDs (61.2%). Using regression analysis, we examined the ability of personality to predict 39 variables from the Life Outcome Questionnaire concerning career, relationships, and mental health. Persistence stood out as the most important dimension regarding career success, with 24.2% of explained variance on average. Self-directedness was the best predictor of social functioning (21.1%), and harm avoidance regarding clinical problems (34.2%). Interpersonal dimensions such as reward dependence and cooperativeness were mostly inconsequential. In general, dimensions were detrimental only in one of their poles. Although personality explains 9.4% of life problems overall, dimensions believed to measure functioning (character) were not better predictors than those measuring style (temperament). The notion that PD diagnoses can be built upon the concept of "personality functioning" is unsupported. Copyright © 2016 Elsevier Inc. All rights reserved.

Sexual abuse, residential schooling and probable pathological gambling among Indigenous Peoples.

PubMed

Dion, Jacinthe; Cantinotti, Michael; Ross, Amélie; Collin-Vézina, Delphine

2015-06-01

Sexual abuse leads to short-term and long-lasting pervasive outcomes, including addictions. Among Indigenous Peoples, sexual abuse experienced in the context of residential schooling may have led to unresolved grief that is contributing to social problems, such as pathological (disordered) gambling. The aim of this study is to investigate the link between child sexual abuse, residential schooling and probable pathological gambling. The participants were 358 Indigenous persons (54.2% women) aged between 18 and 87 years, from two communities and two semi-urban centers in Quebec (Canada). Probable pathological gambling was evaluated using the South Oaks Gambling Screen (SOGS), and sexual abuse and residential schooling were assessed with dichotomous questions (yes/no). The results indicate an 8.7% past-year prevalence rate of pathological gambling problems among participants, which is high compared with the general Canadian population. Moreover, 35.4% were sexually abused, while 28.1% reported having been schooled in a residential setting. The results of a logistic regression also indicate that experiences of child sexual abuse and residential schooling are associated with probable pathological gambling among Indigenous Peoples. These findings underscore the importance of using an ecological approach when treating gambling, to address childhood traumas alongside current addiction problems. Copyright © 2015 Elsevier Ltd. All rights reserved.

Binary Star Orbits. 3. Revisiting the Remarkable Case of Tweedledum and Tweedledee

DTIC Science & Technology

2010-06-11

Observation Date 0.00 0.05 0.10 0.15 0.20 S ep ar at io n D iff er en ce FIN 332 Aa,Ab Unresolved Aa,Ab bB,aBdevlosernU bB,aB 233 NIF 1960 1970 1980 1990...2000 2010 Observation Date 0 50 100 150 200 P os iti on A ng le D iff er en ce FIN 332 Aa,Ab Unresolved Aa,Ab bB,aBdevlosernU bB,aB 233 NIF Figure

Geological model for Boulder 1 at Station 2, South Massif, Valley of Taurus-Littrow

NASA Technical Reports Server (NTRS)

Schmitt, H. H.

1975-01-01

A possible geological model for the origin and history of the materials that make up Boulder 1 is proposed on the basis of firm and probable regional, local, and boulder geological constraints. These constraints are described in detail, unresolved questions are considered, and a model is presented which appears to satisfy all the firm constraints and most of the probable constraints. According to this model, the crystallization of plagioclase and other ANT-suite phases now present in the boulder as clasts and matrix materials took place during the melted-shell stage of lunar history; the original rocks were greatly modified during the cratered-highland stage; and the events that determined the major characteristics of the boulder occurred during the large-basin stage.

Condensed matter physics of planets - Puzzles, progress and predictions

NASA Technical Reports Server (NTRS)

Stevenson, D. J.

1984-01-01

Attention is given to some of the major unresolved issues concerned with the physics of planetary interiors. The important advances in observations, and experimental and theoretical investigations are briefly reviewed, and some areas for further study are identified, including: the characteristics of atomic and electronic degrees of freedom at the high pressures and temperatures typical of a condensed planetary core; the behavior of water at megabar pressures; and the nature of the core-alloy in the earth and in the core mantle phase boundary. Consideration is also given to the behavior of carbon at high pressures and temperatures in the presence of oxygen and hydrogen; the behavior of the volatile ice assemblage in Titan at pressures of 2-40 kbar; and the electrical conductivities of matter under planetary core conditions.

Oxidative Alteration of Ferrous Smectites: A Formation Pathway for Martian Nontronite?

NASA Technical Reports Server (NTRS)

Chemtob, S. M.; Catalano, J. G.; Nickerson, R. D.; Morris, R. V.; Agresti, D. G.; Rivera-Banuchi, V.; Liu, W.; Yee, N.

2017-01-01

Ferric (Fe3+-bearing) smectites, including nontronite, constitute the majority of hydrous mineral exposures observed on Mars. These smectite exposures are commonly interpreted as weathering products of Martian basaltic crust. However, ferrous (Fe2+-dominated) smectites, not ferric, are the thermo-dynamically predicted products of weathering in anoxic conditions, as predicted for early Mars. Earth was anoxic until the Proterozoic Great Oxidation Event; Mars likely experienced an analogous oxidative evolution to its present oxidized state, but the timing of this evolution is unresolved. We hypothesize that Fe3+-smectites observed by orbital spectroscopy are not the initial products of Noachian-era chemical weathering, but are instead the oxidative products of primary Fe2+-smectites. To test this hypothesis experimentally, we synthesized ferrous smectites and exposed them to Mars-relevant oxidants.

Negative vacuum energy densities and the causal diamond measure

DOE Office of Scientific and Technical Information (OSTI.GOV)

Salem, Michael P.

2009-07-15

Arguably a major success of the landscape picture is the prediction of a small, nonzero vacuum energy density. The details of this prediction depend in part on how the diverging spacetime volume of the multiverse is regulated, a question that remains unresolved. One proposal, the causal diamond measure, has demonstrated many phenomenological successes, including predicting a distribution of positive vacuum energy densities in good agreement with observation. In the string landscape, however, the vacuum energy density is expected to take positive and negative values. We find the causal diamond measure gives a poor fit to observation in such a landscapemore » - in particular, 99.6% of observers in galaxies seemingly just like ours measure a vacuum energy density smaller than we do, most of them measuring it to be negative.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sun, Ying; Frankenberg, C.; Wood, Jeff D.

Quantifying gross primary production (GPP) remains a major challenge in global carbon cycle research. Spaceborne monitoring of solar-induced chlorophyll fluorescence (SIF), an integrative photosynthetic signal of molecular origin, can assist in terrestrial GPP monitoring. However, the extent to which SIF tracks spatiotemporal variations in GPP remains unresolved. Orbiting Carbon Observatory-2 (OCO-2)’s SIF data acquisition and fine spatial resolution permit direct validation against ground and airborne observations. Empirical orthogonal function analysis shows consistent spatiotemporal correspondence between OCO-2 SIF and GPP globally. A linear SIF-GPP relationship is also obtained at eddy-flux sites covering diverse biomes, setting the stage for future investigations ofmore » the robustness of such a relationship across more biomes. In conclusion, our findings support the central importance of high-quality satellite SIF for studying terrestrial carbon cycle dynamics.« less

Unresolved Subclinical Hypothyroidism is Independently Associated with Progression of Chronic Kidney Disease

PubMed Central

Kim, Eun Oh; Lee, Ihn Suk; Choi, Yoo A; Lee, Sang Ju; Chang, Yoon Kyung; Yoon, Hye Eun; Jang, Yi Sun; Lee, Jong Min; Kim, Hye Soo; Yang, Chul Woo; Kim, Suk Young; Hwang, Hyeon Seok

2014-01-01

Background and Aim: Patients with chronic kidney disease (CKD) often have subclinical hypothyroidism. However, few reports have investigated changes in the status of subclinical hypothyroidism in CKD patients and its clinical significance in CKD progression. Methods: We included 168 patients with nondialysis-dependent CKD stages 2-4. The normalization of subclinical hypothyroidism during follow-up was assessed, and the association between transitions in subclinical hypothyroid status and the rate of decline of the estimated glomerular filtration rate (eGFR) was investigated. Results: At baseline, 127 patients were euthyroid and 41 (24.4%) patients were diagnosed with subclinical hypothyroidism. Of these 41 patients, 21 (51.2%) spontaneously resolved to euthyroid during follow-up. The rate of eGFR decline of patients with resolved subclinical hypothyroidism was similar to that of euthyroid patients. The patients with unresolved subclinical hypothyroidism showed a steeper renal function decline than patients with euthyroidism or resolved subclinical hypothyroidism (all p < 0.05). The progression to end-stage renal disease was more frequent in those with unresolved subclinical hypothyroidism than in those who were euthyroid (p = 0.006). In multivariate linear regression for rate of eGFR decrease, unresolved subclinical hypothyroidism (β = -5.77, p = 0.001), baseline renal function (β = -0.12, p < 0.001) and level of proteinuria (β = -2.36, p = 0.015) were independently associated with the rate of renal function decline. Conclusions: Half of the CKD patients with subclinical hypothyroidism did not resolve to euthyroidism, and this lack of resolution was independently associated with rapid renal function decline. PMID:24396286

CXB surface brightness fluctuations: A new frontier of ICM structure and outskirts studies of (un)resolved galaxy clusters?

NASA Astrophysics Data System (ADS)

Kolodzig, A.; Gilfanov, M.; Hutsi, G.; Sunyaev, R.

2017-10-01

Surface brightness fluctuations of the cosmic X-ray background (CXB) carry unique information about the intracluster-medium (ICM) structure of galaxy clusters and groups up to the virial radius, which is inaccessible by conventional observations of selected nearby resolved clusters. We present results of our CXB fluctuation analysis of the ˜5ks-deep, ˜9deg^2-large Chandra survey XBOOTES. We find that our fluctuation signal of resolved clusters is dominated by nearby, high-luminosity sources. The shape of its power spectrum suggests that for the brightest cluster we are sensitive to the ICM structure up to ˜2× R_{500};(˜2 Mpc/h). The energy spectrum of the fluctuation signal from resolved and unresolved clusters follows a typical ICM spectrum, where redshifts and temperatures are consistent with expectations. It also demonstrates that fluctuations of our unresolved CXB are dominated by unresolved clusters with an average z˜0.4 and T˜1.3keV, suggesting an average L_{0.5-2keV}˜3×10^{42} erg/s and M_{500}˜4×10^{13} M_{Sun}/h. Comparison with modeling suggests, that our fluctuation signal can be described with the one-halo-term of clusters and that it might be sensitive to the presence of substructures. Discrepancies between model and measurement could be utilized to improve our understanding of the ICM structure in a statistical manner. We briefly discuss the potential of larger surveys (e.g. Stripe82, XXL, SRG/eRosita).

Seeking the chemical roots of darwinism: bridging between chemistry and biology.

PubMed

Pross, Addy

2009-08-24

Chemistry and biology are intimately connected sciences yet the chemistry-biology interface remains problematic and central issues regarding the very essence of living systems remain unresolved. In this essay we build on a kinetic theory of replicating systems that encompasses the idea that there are two distinct kinds of stability in nature-thermodynamic stability, associated with "regular" chemical systems, and dynamic kinetic stability, associated with replicating systems. That fundamental distinction is utilized to bridge between chemistry and biology by demonstrating that within the parallel world of replicating systems there is a second law analogue to the second law of thermodynamics, and that Darwinian theory may, through scientific reductionism, be related to that second law analogue. Possible implications of these ideas to the origin of life problem and the relationship between chemical emergence and biological evolution are discussed.

Turbulent Nuclear Burning of Carbon Fuel in Double-Degenerate White Dwarfs

NASA Astrophysics Data System (ADS)

Mozumdar, Pritom; Fisher, Robert

2018-01-01

Type Ia supernovae (SNe Ia) are of interest as standardizable cosmological candles, though their stellar progenitors are still poorly understood. The double-degenerate (DD) channel is promising, but the mechanism for the explosion remains a matter of active investigation. A long-standing problem in modeling SNe Ia is the fact that 3D simulations leave the length scales crucial for a possible detonation unresolved. In this work, we have performed local 3D hydrodynamical adaptive mesh refinement simulations of driven turbulence for various initial conditions characteristic of the DD scenario, which are capable of capturing length scales relevant to the Zel’dovich gradient mechanism. Because the carbon burning rate is highly sensitive to temperature in this regime, we demonstrate that turbulence can dramatically enhance the nuclear burning rate, and we investigate the connection to a possible detonation.

Towards ab initio Calculations with the Dynamical Vertex Approximation

NASA Astrophysics Data System (ADS)

Galler, Anna; Kaufmann, Josef; Gunacker, Patrik; Pickem, Matthias; Thunström, Patrik; Tomczak, Jan M.; Held, Karsten

2018-04-01

While key effects of the many-body problem — such as Kondo and Mott physics — can be understood in terms of on-site correlations, non-local fluctuations of charge, spin, and pairing amplitudes are at the heart of the most fascinating and unresolved phenomena in condensed matter physics. Here, we review recent progress in diagrammatic extensions to dynamical mean-field theory for ab initio materials calculations. We first recapitulate the quantum field theoretical background behind the two-particle vertex. Next we discuss latest algorithmic advances in quantum Monte Carlo simulations for calculating such two-particle quantities using worm sampling and vertex asymptotics, before giving an introduction to the ab initio dynamical vertex approximation (AbinitioDΓA). Finally, we highlight the potential of AbinitioDΓA by detailing results for the prototypical correlated metal SrVO3.

Present status and future potential of enhancing bone healing using nanotechnology.

PubMed

Stylios, George; Wan, Taoyu; Giannoudis, Peter

2007-03-01

An overview of the current state of tissue engineering material systems used in bone healing is presented. A variety of fabrication processes have been developed that have resulted in porous implant substrates that can address unresolved clinical problems. The merits of these biomaterial systems are evaluated in the context of the mechanical properties and biomedical performances most suitable for bone healing. An optimal scaffold for bone tissue engineering applications should be biocompatible and act as a 3D template for in vitro and in vivo bone growth; in addition, its degradation products should be non-toxic and easily excreted by the body. To achieve these features, scaffolds must consist of an interconnected porous network of micro- and nanoscale to allow extensive body fluid transport through the pores, which will trigger bone ingrowth, cell migration, tissue ingrowth, and eventually vascularization.

Global Antimicrobial Stewardship: A Closer Look at the Formidable Implementation Challenges

PubMed Central

Tiong, John J. L.; Loo, Jason S. E.; Mai, Chun-Wai

2016-01-01

Antimicrobial stewardship (AMS) has been touted as one of the key strategies required in tackling worldwide escalation of antibiotic resistance. Although AMS has optimized antibiotic usage and reduced the incidence of resistance development in some regions, its full global potential has been curtailed by various AMS-impeding factors. This article seeks to highlight in a detailed perspective, the key challenges that hamper global AMS endeavors, some of which include the paucity of effective implementation strategies that cater for the challenging settings of developing nations, the slow response of governments, uncoordinated AMS activities as well as implementation fragmentation across different sectors and countries. The authors of this article call upon all stakeholders to pay attention to these seemingly obvious but often under-addressed problems. If left unresolved, this may render all current and future AMS initiatives pointless. PMID:27899924

Coherent state coding approaches the capacity of non-Gaussian bosonic channels

NASA Astrophysics Data System (ADS)

Huber, Stefan; König, Robert

2018-05-01

The additivity problem asks if the use of entanglement can boost the information-carrying capacity of a given channel beyond what is achievable by coding with simple product states only. This has recently been shown not to be the case for phase-insensitive one-mode Gaussian channels, but remains unresolved in general. Here we consider two general classes of bosonic noise channels, which include phase-insensitive Gaussian channels as special cases: these are attenuators with general, potentially non-Gaussian environment states and classical noise channels with general probabilistic noise. We show that additivity violations, if existent, are rather minor for all these channels: the maximal gain in classical capacity is bounded by a constant independent of the input energy. Our proof shows that coding by simple classical modulation of coherent states is close to optimal.

Ultra-sensitive pressure dependence of bandgap of rutile-GeO2 revealed by many body perturbation theory.

PubMed

Samanta, Atanu; Jain, Manish; Singh, Abhishek K

2015-08-14

The reported values of bandgap of rutile GeO2 calculated by the standard density functional theory within local-density approximation (LDA)/generalized gradient approximation (GGA) show a wide variation (∼2 eV), whose origin remains unresolved. Here, we investigate the reasons for this variation by studying the electronic structure of rutile-GeO2 using many-body perturbation theory within the GW framework. The bandgap as well as valence bandwidth at Γ-point of rutile phase shows a strong dependence on volume change, which is independent of bandgap underestimation problem of LDA/GGA. This strong dependence originates from a change in hybridization among O-p and Ge-(s and p) orbitals. Furthermore, the parabolic nature of first conduction band along X-Γ-M direction changes towards a linear dispersion with volume expansion.

Resolving conflict realistically in today's health care environment.

PubMed

Smith, S B; Tutor, R S; Phillips, M L

2001-11-01

Conflict is a natural part of human interaction, and when properly addressed, results in improved interpersonal relationships and positive organizational culture. Unchecked conflict may escalate to verbal and physical violence. Conflict that is unresolved creates barriers for people, teams, organizational growth, and productivity, leading to cultural disintegration within the establishment. By relying on interdependence and professional collaboration, all parties involved grow and, in turn, benefit the organization and population served. When used in a constructive manner, conflict resolution can help all parties involved see the whole picture, thus allowing freedom for growth and change. Conflict resolution is accomplished best when emotions are controlled before entering into negotiation. Positive confrontation, problem solving, and negotiation are processes used to realistically resolve conflict. Everyone walks away a winner when conflict is resolved in a positive, professional manner (Stone, 1999).

Time-spliced X-ray diffraction imaging of magnetism dynamics in a NdNiO3 thin film

NASA Astrophysics Data System (ADS)

Beyerlein, Kenneth R.

2018-03-01

Diffraction imaging of nonequilibrium dynamics at atomic resolution is becoming possible with X-ray free-electron lasers. However, there are unresolved problems with applying this method to objects that are confined in only one dimension. Here I show that reliable one-dimensional coherent diffraction imaging is possible by splicing together images recovered from different time delays in an optical pump X-ray probe experiment. The time and space evolution of antiferromagnetic order in a vibrationally excited complex oxide heterostructure is recovered from time-resolved measurements of a resonant soft X-ray diffraction peak. Midinfrared excitation of the substrate is shown to lead to a demagnetization front that propagates at a velocity exceeding the speed of sound, a critical observation for the understanding of driven phase transitions in complex condensed matter.

Time-spliced X-ray diffraction imaging of magnetism dynamics in a NdNiO3 thin film.

PubMed

Beyerlein, Kenneth R

2018-02-27

Diffraction imaging of nonequilibrium dynamics at atomic resolution is becoming possible with X-ray free-electron lasers. However, there are unresolved problems with applying this method to objects that are confined in only one dimension. Here I show that reliable one-dimensional coherent diffraction imaging is possible by splicing together images recovered from different time delays in an optical pump X-ray probe experiment. The time and space evolution of antiferromagnetic order in a vibrationally excited complex oxide heterostructure is recovered from time-resolved measurements of a resonant soft X-ray diffraction peak. Midinfrared excitation of the substrate is shown to lead to a demagnetization front that propagates at a velocity exceeding the speed of sound, a critical observation for the understanding of driven phase transitions in complex condensed matter.

High-Energy Electron-Ion and Photon-Ion Collisions: Status and Challenges

NASA Technical Reports Server (NTRS)

Kallman, Timothy R.

2010-01-01

Non-LTE plasmas are ubiquitous in objects studied in the UV and X-ray energy bands. Collisional and photoionization cross sections for atoms and ions are fundamental to our ability to model such plasmas. Modeling is key in the X-ray band, where detector properties and limited spectral resolution limit the ability to measure model-independent line strengths, or other spectral features. Much of the motivation for studying such collisions and many of the tools, are not new. However, the motivation for such studies and their applications, have been affected by the advent of X-ray spectroscopy with the gratings on Chandra and XMM-Newton. In this talk I will review this motivation and describe the tools currently in use for such studies. I will also describe some current unresolved problems and the likely future needs for such data.

Analysis of temperature-dependent neutron transmission and self-indication measurements on tantalum at 2-keV neutron energy

NASA Technical Reports Server (NTRS)

Semler, T. T.

1973-01-01

The method of pseudo-resonance cross sections is used to analyze published temperature-dependent neutron transmission and self-indication measurements on tantalum in the unresolved region. In the energy region analyzed, 1825.0 to 2017.0 eV, a direct application of the pseudo-resonance approach using a customary average strength function will not provide effective cross sections which fit the measured cross section behavior. Rather a local value of the strength function is required, and a set of resonances which model the measured behavior of the effective cross sections is derived. This derived set of resonance parameters adequately represents the observed resonance hehavior in this local energy region. Similar analyses for the measurements in other unresolved energy regions are necessary to obtain local resonance parameters for improved reactor calculations. This study suggests that Doppler coefficients calculated by sampling from grand average statistical distributions over the entire unresolved resonance region can be in error, since significant local variations in the statistical distributions are not taken into consideration.

Simulated cosmic microwave background maps at 0.5 deg resolution: Unresolved features

NASA Technical Reports Server (NTRS)

Kogut, A.; Hinshaw, G.; Bennett, C. L.

1995-01-01

High-contrast peaks in the cosmic microwave background (CMB) anisotropy can appear as unresolved sources to observers. We fit simluated CMB maps generated with a cold dark matter model to a set of unresolved features at instrumental resolution 0.5 deg-1.5 deg to derive the integral number density per steradian n (greater than absolute value of T) of features brighter than threshold temperature absolute value of T and compare the results to recent experiments. A typical medium-scale experiment observing 0.001 sr at 0.5 deg resolution would expect to observe one feature brighter than 85 micro-K after convolution with the beam profile, with less than 5% probability to observe a source brighter than 150 micro-K. Increasing the power-law index of primordial density perturbations n from 1 to 1.5 raises these temperature limits absolute value of T by a factor of 2. The MSAM features are in agreement with standard cold dark matter models and are not necessarily evidence for processes beyond the standard model.

Barriers to malaria control in rural south-west Timor-Leste: a qualitative analysis.

PubMed

Neave, Penny E; Soares, Maria L

2014-01-01

Malaria is an important health problem in Timor-Leste. Although funding has been provided to reduce the burden of this disease, few studies have investigated whether this has improved malaria-related knowledge, management of symptoms, and treatment in rural communities. The aim of this study was to explore the perceptions and practices undertaken in relation to all aspects of malaria control by members of two rural communities in Timor-Leste. A qualitative study was undertaken in two rural hamlets in Timor-Leste. Research methods included transect walks, focus groups and semi-structured interviews. Content analysis was used to identify themes. The location of the hamlets near rice fields, leaking taps, inadequate water supplies and dumping of waste from the local hospital provided opportunities for mosquitoes to breed. Most participants were aware of the link between mosquitoes and malaria, but a lack of control over their environment was a major barrierto preventing malaria. The distribution ofbed nets had occurred once, and was the only intervention undertaken bythe National Malaria Control Programme. However, limiting the distribution of bed nets to pregnant women and children aged under 5 years had resulted in some focus group respondents believing that only those in these groups could be affected by malaria. Self-diagnosis and home treatmentwere common. Treatment for unresolved infections depended on access to transport funds, and belief in the power of traditional healers. Improvements in infrastructure, empowerment of rural communities, and better access to treatment are recommended if the incidence of malaria is to be reduced throughout the country.

A review of the structure-property relationships in lead-free piezoelectric (1−x)Na{sub 0.5}Bi{sub 0.5}TiO{sub 3}–(x)BaTiO{sub 3}

DOE Office of Scientific and Technical Information (OSTI.GOV)

McQuade, Ryan R.; Dolgos, Michelle R., E-mail: Michelle.Dolgos@oregonstate.edu

2016-10-15

Piezoelectric materials are increasingly being investigated for energy harvesting applications where (1−x)Na{sub 0.5}Bi{sub 0.5}TiO{sub 3}–(x)BaTiO{sub 3} (NBT-BT) is an important lead-free piezoelectric material with potential to be used as an actuator in energy harvesting devices. Much effort has been put into modifying NBT-BT to tune the properties for specific applications, but there is currently no consensus regarding the structure-property relationships in this material, making targeted, rational design a major challenge. In this review, we will summarize the current body of knowledge of NBT-BT and discuss contradicting studies, unresolved problems, and future directions in the field. - Graphical abstract: This reviewmore » of (1−x)Na{sub 0.5}Bi{sub 0.5}TiO{sub 3}–(x)BaTiO{sub 3} (NBT-BT) summarizes the large body of literature regarding the structure-property relationships of this complex material. We highlight structural studies of the average and local structures of both unpoled and poled samples of NBT-BT at its morphotropic phase boundary and discuss them in context of the observed piezoelectric properties. - Highlights: • Local and average structure of NBT-BT at morphotropic phase boundary is reviewed. • Average structure of poled and unpoled samples of NBT-BT is discussed. • Structure-property relationships in NBT-BT and future directions are summarized.« less

Umbilical Cord Blood Transplantation Supported by Third Party Donor Cells: Rationale, Results and Applications

PubMed Central

van Besien, Koen; Liu, Hongtao; Jain, Nitin; Stock, Wendy; Artz, Andrew

2012-01-01

Low incidence of GVHD provides the major rational for pursuing UCB stem cell transplant (UCB SCT). Considerable evidence also suggests a lower rate of recurrence after UCB SCT than after transplantation from adult donors. Recent advances in understanding of the human fetal immune development provide a rational underpinning for these clinical outcomes. The fetal immune system is geared toward maintaining tolerance to foreign antigens, particularly to the maternal antigens to which it is exposed throughout gestation. To this purpose it is dominated by a unique population of peripheral T regulatory cells which actively maintain tolerance. This and other features of the UCB lymphoid system explains the low incidence of GVHD and superior outcomes of UCB SCT with NIMA (non-inherited maternal antigens)-matched grafts. At the same time, highly sensitized maternal microchimeric cells are frequently detected in UCB and likely contribute to superior GVL effects and low rates of disease recurrence in IPA (inherited paternal antigen) matched UCB recipients. But historically erratic and slow hematopoietic recovery after UCB SCT leads to increased early morbidity and mortality, excessive hospitalization and costs. This has held up the widespread utilization of UCB SCT in adults. Here we summarize recent data on UCB SCT with an emphasis on studies of co-infusion of adult CD34 selected hematopoietic stem cells with UCB SCT. This procedure, through transient engraftment of adult hematopoietic stem cells largely overcomes the problem of delayed engraftment. We also briefly discuss unresolved issues and possible future applications of this technology. PMID:23142329

Structure and Soot Formation Properties of Laminar Flames

NASA Technical Reports Server (NTRS)

El-Leathy, A. M.; Xu, F.; Faeth, G. M.

2001-01-01

Soot formation within hydrocarbon-fueled flames is an important unresolved problem of combustion science for several reasons: soot emissions are responsible for more deaths than any other combustion-generated pollutant, thermal loads due to continuum radiation from soot limit the durability of combustors, thermal radiation from soot is mainly responsible for the growth and spread of unwanted fires, carbon monoxide emissions associated with soot emissions are responsible for most fire deaths, and limited understanding of soot processes in flames is a major impediment to the development of computational combustion. Motivated by these observations, soot processes within laminar premixed and nonpremixed (diffusion) flames are being studied during this investigation. The study is limited to laminar flames due to their experimental and computational tractability, noting the relevance of these results to practical flames through laminar flamelet concepts. Nonbuoyant flames are emphasized because buoyancy affects soot processes in laminar diffusion flames whereas effects of buoyancy are small for most practical flames. This study involves both ground- and space-based experiments, however, the following discussion will be limited to ground-based experiments because no space-based experiments were carried out during the report period. The objective of this work was to complete measurements in both premixed and nonpremixed flames in order to gain a better understanding of the structure of the soot-containing region and processes of soot nucleation and surface growth in these environments, with the latter information to be used to develop reliable ways of predicting soot properties in practical flames. The present discussion is brief, more details about the portions of the investigation considered here can be found in refs. 8-13.

The carina angle-new geometrical parameter associated with periprocedural side branch compromise and the long-term results in coronary bifurcation lesions with main vessel stenting only.

PubMed

Gil, Robert J; Vassilev, Dobrin; Formuszewicz, Radoslaw; Rusicka-Piekarz, Teresa; Doganov, Alexander

2009-12-01

The two main problems unresolved in coronary bifurcation stenting are periprocedural side branch compromise and higher restenosis at long term. The purpose of this study is to reveal the link between periprocedural side branch compromise and long-term results after main vessel stenting only in coronary bifurcations. Eighty-four patients formed the study population. The inclusion criteria were good-quality angiograms, with maximal between-branch angle opening, no overlap, permitting accurate angiographic analysis. Carina angle (alpha)-the distal angle between main vessel (MV) before bifurcation and side branch (SB)-was measured pre- and poststenting. Clinical follow-up 9-12 months was obtained with coronary angiography if needed. The patient population was high-risk with 33% diabetics and 84% two- and three-vessel disease. Ninety-five stents were implanted in 92 lesions, with three T-stenting cases. Drug-eluting stents were implanted in 54%. Kissing-balloon (KBI) or sequential inflation was performed in 35%. SB functional closure occurred in 17.4%, with independent predictors alpha < 40 degrees and diameter ratio MB/SB >1.22. After 12+/-4 months there were five myocardial infarctions (6%) and 13 (15%) target lesion revascularization procedures. Independent predictors of major cardiovascular events were carina angle <40 degrees , MB lesion length >8 mm, negative change of between-branch angle, DES usage, and KBI. Smaller carina angle with straightening of MV-main branch from stent implantation in coronary bifurcations predicted higher SB compromise, restenosis, and MACE rates during follow-up of 1 year.

Saudi English-Major Undergraduates' Academic Writing Problems: A Taif University Perspective

ERIC Educational Resources Information Center

Al-Khairy, Mohamed Ali

2013-01-01

This study attempted to investigate Saudi English-major undergraduates studying at Taif University to identify a) the types of academic writing Saudi English-major undergraduates carry out at English departments, b) Saudi English-major undergraduates' writing problems, c) the reasons behind Saudi English-major undergraduates' writing problems and…

A computer program for analyzing unresolved Mossbauer hyperfine spectra

NASA Technical Reports Server (NTRS)

Schiess, J. R.; Singh, J. J.

1978-01-01

The program for analyzing unresolved Mossbauer hyperfine spectra was written in FORTRAN 4 language for the Control Data CYBER 170 series digital computer system with network operating system 1.1. With the present dimensions, the program requires approximately 36,000 octal locations of core storage. A typical case involving two innermost coordination shells in which the amplitudes and the peak positions of all three components were estimated in 25 iterations requires 30 seconds on CYBER 173. The program was applied to determine the effects of various near neighbor impurity shells on hyperfine fields in dilute FeAl alloys.

Dependence of NOAA-AVHRR recorded radiance on scan angle, atmospheric turbidity and unresolved cloud

NASA Technical Reports Server (NTRS)

Piwinski, D. J.; Schoch, L. B.; Duggin, M. J.; Whitehead, V.; Ryland, E.

1984-01-01

Experimental evidence on the scan angle and sun angle dependence of radiance recorded by the Advanced Very High Resolution Radiometer (AVHRR) devices on the NOAA-6 and NOAA-7 satellites is presented. The effects of atmospheric turbidity at various scan angles is shown, and simulations of angular anisotropy and recorded radiance are compared with the recorded digital data from the AVHRR obtained over the Great Plains area of the US. Evidence is presented on the effects of unresolved cloud on the recorded radiance and vegetative indices from uniform, vegetative targets.

Brainstem auditory responses to resolved and unresolved harmonics of a synthetic vowel in quiet and noise.

PubMed

Laroche, Marilyn; Dajani, Hilmi R; Prévost, François; Marcoux, André M

2013-01-01

This study investigated speech auditory brainstem responses (speech ABR) with variants of a synthetic vowel in quiet and in background noise. Its objectives were to study the noise robustness of the brainstem response at the fundamental frequency F0 and at the first formant F1, evaluate how the resolved/unresolved harmonics regions in speech contribute to the response at F0, and investigate the origin of the response at F0 to resolved and unresolved harmonics in speech. In total, 18 normal-hearing subjects (11 women, aged 18-33 years) participated in this study. Speech ABRs were recorded using variants of a 300 msec formant-synthesized /a/ vowel in quiet and in white noise. The first experiment employed three variants containing the first three formants F1 to F3, F1 only, and F2 and F3 only with relative formant levels following those reported in the literature. The second experiment employed three variants containing F1 only, F2 only, and F3 only, with the formants equalized to the same level and the signal-to-noise ratio (SNR) maintained at -5 dB. Overall response latency was estimated, and the amplitude and local SNR of the envelope following response at F0 and of the frequency following response at F1 were compared for the different stimulus variants in quiet and in noise. The response at F0 was more robust to noise than that at F1. There were no statistically significant differences in the response at F0 caused by the three stimulus variants in both experiments in quiet. However, the response at F0 with the variant dominated by resolved harmonics was more robust to noise than the response at F0 with the stimulus variants dominated by unresolved harmonics. The latencies of the responses in all cases were very similar in quiet, but the responses at F0 due to resolved and unresolved harmonics combined nonlinearly when both were present in the stimulus. Speech ABR has been suggested as a marker of central auditory processing. The results of this study support earlier work on the differential susceptibility to noise of the F0 and F1 components of the evoked response. In the case of F0, the results support the view that in speech, the pitch of resolved harmonics and that of unresolved harmonics are processed in different but interacting pathways that converge in the upper brainstem. Pitch plays an important role in speech perception, and speech ABR can offer a window into the neural extraction of the pitch of speech and how it may change with hearing impairment.

Modeling Interactions Among Turbulence, Gas-Phase Chemistry, Soot and Radiation Using Transported PDF Methods

NASA Astrophysics Data System (ADS)

Haworth, Daniel

2013-11-01

The importance of explicitly accounting for the effects of unresolved turbulent fluctuations in Reynolds-averaged and large-eddy simulations of chemically reacting turbulent flows is increasingly recognized. Transported probability density function (PDF) methods have emerged as one of the most promising modeling approaches for this purpose. In particular, PDF methods provide an elegant and effective resolution to the closure problems that arise from averaging or filtering terms that correspond to nonlinear point processes, including chemical reaction source terms and radiative emission. PDF methods traditionally have been associated with studies of turbulence-chemistry interactions in laboratory-scale, atmospheric-pressure, nonluminous, statistically stationary nonpremixed turbulent flames; and Lagrangian particle-based Monte Carlo numerical algorithms have been the predominant method for solving modeled PDF transport equations. Recent advances and trends in PDF methods are reviewed and discussed. These include advances in particle-based algorithms, alternatives to particle-based algorithms (e.g., Eulerian field methods), treatment of combustion regimes beyond low-to-moderate-Damköhler-number nonpremixed systems (e.g., premixed flamelets), extensions to include radiation heat transfer and multiphase systems (e.g., soot and fuel sprays), and the use of PDF methods as the basis for subfilter-scale modeling in large-eddy simulation. Examples are provided that illustrate the utility and effectiveness of PDF methods for physics discovery and for applications to practical combustion systems. These include comparisons of results obtained using the PDF method with those from models that neglect unresolved turbulent fluctuations in composition and temperature in the averaged or filtered chemical source terms and/or the radiation heat transfer source terms. In this way, the effects of turbulence-chemistry-radiation interactions can be isolated and quantified.

Whiplash and the compensation hypothesis.

PubMed

Spearing, Natalie M; Connelly, Luke B

2011-12-01

Review article. To explain why the evidence that compensation-related factors lead to worse health outcomes is not compelling, either in general, or in the specific case of whiplash. There is a common view that compensation-related factors lead to worse health outcomes ("the compensation hypothesis"), despite the presence of important, and unresolved sources of bias. The empirical evidence on this question has ramifications for the design of compensation schemes. Using studies on whiplash, this article outlines the methodological problems that impede attempts to confirm or refute the compensation hypothesis. Compensation studies are prone to measurement bias, reverse causation bias, and selection bias. Errors in measurement are largely due to the latent nature of whiplash injuries and health itself, a lack of clarity over the unit of measurement (specific factors, or "compensation"), and a lack of appreciation for the heterogeneous qualities of compensation-related factors and schemes. There has been a failure to acknowledge and empirically address reverse causation bias, or the likelihood that poor health influences the decision to pursue compensation: it is unclear if compensation is a cause or a consequence of poor health, or both. Finally, unresolved selection bias (and hence, confounding) is evident in longitudinal studies and natural experiments. In both cases, between-group differences have not been addressed convincingly. The nature of the relationship between compensation-related factors and health is unclear. Current approaches to testing the compensation hypothesis are prone to several important sources of bias, which compromise the validity of their results. Methods that explicitly test the hypothesis and establish whether or not a causal relationship exists between compensation factors and prolonged whiplash symptoms are needed in future studies.

Geostatistical Analysis of Mesoscale Spatial Variability and Error in SeaWiFS and MODIS/Aqua Global Ocean Color Data

NASA Astrophysics Data System (ADS)

Glover, David M.; Doney, Scott C.; Oestreich, William K.; Tullo, Alisdair W.

2018-01-01

Mesoscale (10-300 km, weeks to months) physical variability strongly modulates the structure and dynamics of planktonic marine ecosystems via both turbulent advection and environmental impacts upon biological rates. Using structure function analysis (geostatistics), we quantify the mesoscale biological signals within global 13 year SeaWiFS (1998-2010) and 8 year MODIS/Aqua (2003-2010) chlorophyll a ocean color data (Level-3, 9 km resolution). We present geographical distributions, seasonality, and interannual variability of key geostatistical parameters: unresolved variability or noise, resolved variability, and spatial range. Resolved variability is nearly identical for both instruments, indicating that geostatistical techniques isolate a robust measure of biophysical mesoscale variability largely independent of measurement platform. In contrast, unresolved variability in MODIS/Aqua is substantially lower than in SeaWiFS, especially in oligotrophic waters where previous analysis identified a problem for the SeaWiFS instrument likely due to sensor noise characteristics. Both records exhibit a statistically significant relationship between resolved mesoscale variability and the low-pass filtered chlorophyll field horizontal gradient magnitude, consistent with physical stirring acting on large-scale gradient as an important factor supporting observed mesoscale variability. Comparable horizontal length scales for variability are found from tracer-based scaling arguments and geostatistical decorrelation. Regional variations between these length scales may reflect scale dependence of biological mechanisms that also create variability directly at the mesoscale, for example, enhanced net phytoplankton growth in coastal and frontal upwelling and convective mixing regions. Global estimates of mesoscale biophysical variability provide an improved basis for evaluating higher resolution, coupled ecosystem-ocean general circulation models, and data assimilation.

Phylogenomic analyses of Crassiclitellata support major Northern and Southern Hemisphere clades and a Pangaean origin for earthworms.

PubMed

Anderson, Frank E; Williams, Bronwyn W; Horn, Kevin M; Erséus, Christer; Halanych, Kenneth M; Santos, Scott R; James, Samuel W

2017-05-30

Earthworms (Crassiclitellata) are a diverse group of annelids of substantial ecological and economic importance. Earthworms are primarily terrestrial infaunal animals, and as such are probably rather poor natural dispersers. Therefore, the near global distribution of earthworms reflects an old and likely complex evolutionary history. Despite a long-standing interest in Crassiclitellata, relationships among and within major clades remain unresolved. In this study, we evaluate crassiclitellate phylogenetic relationships using 38 new transcriptomes in combination with publicly available transcriptome data. Our data include representatives of nearly all extant earthworm families and a representative of Moniligastridae, another terrestrial annelid group thought to be closely related to Crassiclitellata. We use a series of differentially filtered data matrices and analyses to examine the effects of data partitioning, missing data, compositional and branch-length heterogeneity, and outgroup inclusion. We recover a consistent, strongly supported ingroup topology irrespective of differences in methodology. The topology supports two major earthworm clades, each of which consists of a Northern Hemisphere subclade and a Southern Hemisphere subclade. Divergence time analysis results are concordant with the hypothesis that these north-south splits are the result of the breakup of the supercontinent Pangaea. These results support several recently proposed revisions to the classical understanding of earthworm phylogeny, reveal two major clades that seem to reflect Pangaean distributions, and raise new questions about earthworm evolutionary relationships.

Protecting indigenous rights. Guatemala.

PubMed

1996-01-01

Guatemala's recent ratification of the International Labor Organization (ILO) Convention regarding indigenous and tribal peoples (1989, No. 169) represents a commitment to guarantee the rights of the country's majority Mayan population. Ratifying governments are obligated to respect the traditional values and land rights of tribal and indigenous peoples and to consult with them on any decisions affecting their economic or social development. Ratification of this Convention was a key element in an eight-part UN-sponsored negotiation aimed at ending the civil war in Guatemala. Efforts are underway to promote dialogue between organized civil society and government. Negotiations in May 1996, conducted with ILO assistance, resulted in a socioeconomic agreement under which Guatemala will increase social investment in education, undertake agrarian reform, and institute tripartite consultation on all major social and economic issues. However, two key issues in the peace negotiations--the role of the army in civil society and constitutional reform--remain unresolved. The final global peace accord is expected to be signed in September 1996. UN organizations are already working to mobilize international support for transforming these agreements into political and social realities for the Guatemalan people.

Urban rivers as conveyors of hydrocarbons to sediments of estuarine areas: source characterization, flow rates and mass accumulation.

PubMed

Mauad, Cristiane R; Wagener, Angela de L R; Massone, Carlos G; Aniceto, Mayara da S; Lazzari, Letícia; Carreira, Renato S; Farias, Cássia de O

2015-02-15

Aliphatic (n-C12-n-C40, unresolved complex mixture, resolved peaks) and aromatic hydrocarbons (46 PAH) were investigated in suspended particulate matter (SPM) sampled over eleven months in six of the major rivers and two channels of the Guanabara Bay Basin. PAH flow rates of the most contaminated rivers, the contribution to the PAH sediment load of the receiving bay, and the main sources of hydrocarbons were determined. PAH (38) ranged from 28 ng L(-1) to 11,514 ng L(-1). Hydrocarbon typology and statistical evaluation demonstrated contribution of distinct sources in different regions and allowed quantification of these contributions. Total flow rate for the five major rivers amounts to 3 t year(-1) and responds for 30% of the total PAH annual input into the northern area of the Guanabara Bay. For the first time PAH mass deposited in the bay sediments has been estimated and shall serve as base for decision making and source abatement. Copyright © 2014 Elsevier B.V. All rights reserved.

Occurrence, source and ecological assessment of baseline hydrocarbons in the intertidal marine sediments along the shoreline of Douglas Channel to Hecate Strait in British Columbia.

PubMed

Yang, Zeyu; Hollebone, Bruce P; Laforest, Sonia; Lambert, Patrick; Brown, Carl E; Yang, Chun; Shah, Keval; Landriault, Mike; Goldthorp, Michael

2017-09-15

The occurrence, source and ecological assessment of baseline hydrocarbons in the intertidal zone along the northern British shoreline were evaluated based on analyzing total petroleum hydrocarbons (TPH), n-alkanes, petroleum related biomarkers such as terpanes and steranes, and polycyclic aromatic hydrocarbons (PAHs) including non-alkylated and alkylated homologues (APAHs). The TPH levels, n-alkanes, petroleum biomarkers and PAHs in all the sampling sites, except for Masset Harbor/York Point at Gil Island were low, without obvious unresolved complex mixture (UCM) and petroleum contamination input. Specifically, n-alkanes showed a major terrestrial plants input; PAHs with abundant non-alkylated PAHs but minor APAHs showed a major pyrogenic input. However, obvious petroleum-derived hydrocarbons have impacted Masset Harbor. A historical petroleum input was found in York Point at Gil Island, due to the presence of the low level of petroleum biomarkers. Ecological assessment of 13 non-alkylated PAHs in Masset Harbor indicated no potential toxicity to the benthic organisms. Copyright © 2017 Elsevier Ltd. All rights reserved.

Mapping Kainate Activation of Inner Neurons in the Rat Retina

PubMed Central

Nivison-Smith, Lisa; Sun, Daniel; Fletcher, Erica L.; Marc, Robert E.; Kalloniatis, Michael

2014-01-01

Kainate receptors mediate fast, excitatory synaptic transmission for a range of inner neurons in the mammalian retina. However, allocation of functional kainate receptors to known cell types and their sensitivity remains unresolved. Using the cation channel probe 1-amino-4-guanidobutane agmatine (AGB), we investigated kainate sensitivity of neurochemically identified cell populations within the structurally intact rat retina. Most inner retinal neuron populations responded to kainate in a concentration-dependent manner. OFF cone bipolar cells demonstrated the highest sensitivity of all inner neurons to kainate. Immunocytochemical localization of AGB and macromolecular markers confirmed that type 2 bipolar cells were part of this kainate-sensitive population. The majority of amacrine (ACs) and ganglion cells (GCs) showed kainate responses with different sensitivities between major neurochemical classes (γ-aminobutyric acid [GABA]/glycine ACs > glycine ACs > GABA ACs; glutamate [Glu]/weakly GABA GCs > Glu GCs). Conventional and displaced cholinergic ACs were highly responsive to kainate, whereas dopaminergic ACs do not appear to express functional kainate receptors. These findings further contribute to our understanding of neuronal networks in complex multicellular tissues. PMID:23348566

A Circumstellar Disk around HD 169142 in the Mid-Infrared (N-Band)

NASA Astrophysics Data System (ADS)

Okamoto, Yoshiko Kataza; Kataza, Hirokazu; Honda, M.; Yamashita, T.; Fujiyoshi, T.; Miyata, T.; Sako, S.; Fujiwara, H.; Sakon, I.; Fukagawa, M.; Momose, M.; Onaka, T.

2017-07-01

The Herbig Ae star HD 169142 is one of the objects that show complex structure, such as multiple (innermost, middle, and outer) disks, gaps, and unresolved sources. We made N-band (8-13 μm) observations of HD 169142 with the Cooled Mid-Infrared Camera and Spectrometer on the 8.2 m Subaru Telescope. The images are spatially resolved out to an ˜1″ radius in all the observed bands. We made a simple disk model composed of an unresolved central source (representing the innermost disk/halo) and the ring at a radius r ˜ 25 au (corresponding to the inner wall or edge of a middle disk at ˜25-40 au). The radial intensity profile within the central region (≲0.″3 or ≲ 40 au) is well reproduced by the model. Furthermore, we subtracted the model image from the observed one to search for additional structures. In the model-subtracted images, we found an unresolved west source separated by 17.0 ± 2.9 au in the direction of position angle 260° ± 5° from the original emission peak, which is supposed to correspond to the position of the central star, and a bright east arc located at r ˜ 60 au. The west source is different from the L‧-band unresolved source recently found in coronagraphic observations. It could be a structure related to planet formation in the disk, such as a circumplanetary disk or clumpy disk structure. The east arc corresponds to the inner wall or edge of the outer disk. Based on data collected at the Subaru Telescope, which is operated by the National Astronomical Observatory of Japan.

Starch Metabolism in Arabidopsis

PubMed Central

Streb, Sebastian; Zeeman, Samuel C.

2012-01-01

Starch is the major non-structural carbohydrate in plants. It serves as an important store of carbon that fuels plant metabolism and growth when they are unable to photosynthesise. This storage can be in leaves and other green tissues, where it is degraded during the night, or in heterotrophic tissues such as roots, seeds and tubers, where it is stored over longer time periods. Arabidopsis accumulates starch in many of its tissues, but mostly in its leaves during the day. It has proven to be a powerful genetic system for discovering how starch is synthesised and degraded, and new proteins and processes have been discovered. Such work has major significance for our starch crops, whose yield and quality could be improved by the application of this knowledge. Research into Arabidopsis starch metabolism has begun to reveal how its daily turnover is integrated into the rest of metabolism and adapted to the environmental conditions. Furthermore, Arabidopsis mutant lines deficient in starch metabolism have been employed as tools to study other biological processes ranging from sugar sensing to gravitropism and flowering time control. This review gives a detailed account of the use of Arabidopsis to study starch metabolism. It describes the major discoveries made and presents an overview of our understanding today, together with some as-yet unresolved questions. PMID:23393426

Characterictics and Sources of Organic Tracers in Atmospheric Particulate Matter from the Eastern Region of Saudi Arabia

NASA Astrophysics Data System (ADS)

Rushdi, A. I.; El-Mubarak, A. H.; Luis, L.; Mubarak, A. T.; Qurban, M.; Al-Mutlaq, K. F.; Simoneit, B. R.

2013-12-01

The formation and sources of atmospheric particulate matter (PM) can affect air quality of metropolitan areas as well as climate change. Their chemical components can be toxic to humans and hazardous to the environment. Saudi Arabia is witnessing new development and industrial activities, which are expected to contribute to natural, regional and anthropogenic PM inputs of organic tracers. This work investigates the characteristics and sources of the extractable organic matter (EOM) in atmospheric suspended PM from the city of Dhahran in the eastern part of Saudi Arabia. The major compounds were an unresolved complex mixture (UCM) of branched and cyclic hydrocarbons (12-70% of EOM), plasticizers (7-30% of EOM for aryl phosphates and 4-18% of EOM for phthalates), n-alkanes (3-15% of EOM), hopane biomarkers (0.1-4.2% of EOM), n-alkanones (0.3-1.7% of EOM), PAHs (0.1-0.6% of EOM), sterane biomarkers (0.0-0.1% of EOM), and sterols (0.0-0.1% of EOM). Plasticizers are evidently major compounds (11- 48% of EOM) in the suspended PM of Dhahran, which likely have serious public health effects and environmental consequences. The major sources of these organic tracers are emissions from industrial factories north of the city, plastics and biomass burning, and petroleum product combustion.

Molecular phylogeny of the Acre clade (Crassulaceae): dealing with the lack of definitions for Echeveria and Sedum.

PubMed

Carrillo-Reyes, Pablo; Sosa, Victoria; Mort, Mark E

2009-10-01

The phylogenetic relationships within many clades of the Crassulaceae are still uncertain, therefore in this study attention was focused on the "Acre clade", a group comprised of approximately 526 species in eight genera that include many Asian and Mediterranean species of Sedum and the majority of the American genera (Echeveria, Graptopetalum, Lenophyllum, Pachyphytum, Villadia, and Thompsonella). Parsimony and Bayesian analyses were conducted with 133 species based on nuclear (ETS, ITS) and chloroplast DNA regions (rpS16, matK). Our analyses retrieved four major clades within the Acre clade. Two of these were in a grade and corresponded to Asian species of Sedum, the rest corresponded to a European-Macaronesian group and to an American group. The American group included all taxa that were formerly placed in the Echeverioideae and the majority of the American Sedoideae. Our analyses support the monophyly of three genera--Lenophyllum, Thompsonella, and Pachyphytum; however, the relationships among Echeveria, Sedum and the various segregates of Sedum are largely unresolved. Our analyses represents the first broad phylogenetic framework for Acre clade, but further studies are necessary on the groups poorly represented here, such as the European and Asian species of Sedum and the Central and South American species of Echeveria.

What have health care reforms achieved in Turkey? An appraisal of the "Health Transformation Programme".

PubMed

Ökem, Zeynep Güldem; Çakar, Mehmet

2015-09-01

Poor health status indicators, low quality care, inequity in the access to health services and inefficiency due to fragmented health financing and provision have long been problems in Turkey's health system. To address these problems a radical reform process known as the Health Transformation Programme (HTP) was initiated in 2003. The health sector reforms in Turkey are considered to have been among the most successful of middle-income countries undergoing reform. Numerous articles have been published that review these reforms in terms of, variously, financial sustainability, efficiency, equity and quality. Evidence suggests that Turkey has indeed made significant progress, yet these achievements are uneven among its regions, and their long-term financial sustainability is unresolved due to structural problems in employment. As yet, there is no comprehensive evidence-based analysis of how far the stated reform objectives have been achieved. This article reviews the empirical evidence regarding the outcomes of the HTP during 10 years of its implementation. Strengthening the strategic purchasing function of the Social Security Institution (SSI) should be a priority. Overall performance can be improved by linking resource allocation to provider performance. More emphasis on prevention rather than treatment, with an effective referral chain, can also bring better outcomes, greater efficiency gains and contribute to sustainability. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

[Unresolved issues in the evaluation of research projects involving induced pluripotent stem cells (iPS)].

PubMed

Casado, María; de Lecuona, Itziar

2013-01-01

This paper identifies problems and analyzes those conflicts posed by the evaluation of research projects involving the collection and use of human induced pluripotent stem cells (iPS) in Spain. Current legislation is causing problems of interpretation, circular and unnecessary referrals, legal uncertainty and undue delays. Actually, this situation may cause a lack of control and monitoring, and even some paralysis in regenerative medicine and cell therapy research, that is a priority nowadays. The analysis of the current legislation and its bioethical implications, led us to conclude that the review of iPS research projects cannot be assimilated to the evaluation of research projects that involve human embryonic stem cell (hESC). In this context, our proposal is based on the review by the Research Ethics Committees and the checkout by the Spanish Comission of Guarantees for Donation and Use of Human Cells and Tissues (CGDUCTH) of human iPS cells research projects. Moreover, this article claims for a more transparent research system, by effectively articulating the Registry on Research Projects. Finally, a model of verification protocol (checklist) for checking out biomedical research projects involving human iPS cells is suggested.

Verification of unfold error estimates in the UFO code

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fehl, D.L.; Biggs, F.

Spectral unfolding is an inverse mathematical operation which attempts to obtain spectral source information from a set of tabulated response functions and data measurements. Several unfold algorithms have appeared over the past 30 years; among them is the UFO (UnFold Operator) code. In addition to an unfolded spectrum, UFO also estimates the unfold uncertainty (error) induced by running the code in a Monte Carlo fashion with prescribed data distributions (Gaussian deviates). In the problem studied, data were simulated from an arbitrarily chosen blackbody spectrum (10 keV) and a set of overlapping response functions. The data were assumed to have anmore » imprecision of 5% (standard deviation). 100 random data sets were generated. The built-in estimate of unfold uncertainty agreed with the Monte Carlo estimate to within the statistical resolution of this relatively small sample size (95% confidence level). A possible 10% bias between the two methods was unresolved. The Monte Carlo technique is also useful in underdetemined problems, for which the error matrix method does not apply. UFO has been applied to the diagnosis of low energy x rays emitted by Z-Pinch and ion-beam driven hohlraums.« less

Using comparative genome analysis to identify problems in annotated microbial genomes.

PubMed

Poptsova, Maria S; Gogarten, J Peter

2010-07-01

Genome annotation is a tedious task that is mostly done by automated methods; however, the accuracy of these approaches has been questioned since the beginning of the sequencing era. Genome annotation is a multilevel process, and errors can emerge at different stages: during sequencing, as a result of gene-calling procedures, and in the process of assigning gene functions. Missed or wrongly annotated genes differentially impact different types of analyses. Here we discuss and demonstrate how the methods of comparative genome analysis can refine annotations by locating missing orthologues. We also discuss possible reasons for errors and show that the second-generation annotation systems, which combine multiple gene-calling programs with similarity-based methods, perform much better than the first annotation tools. Since old errors may propagate to the newly sequenced genomes, we emphasize that the problem of continuously updating popular public databases is an urgent and unresolved one. Due to the progress in genome-sequencing technologies, automated annotation techniques will remain the main approach in the future. Researchers need to be aware of the existing errors in the annotation of even well-studied genomes, such as Escherichia coli, and consider additional quality control for their results.

Examination of various roles for covariance matrices in the development, evaluation, and application of nuclear data

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smith, D.L.

The last decade has been a period of rapid development in the implementation of covariance-matrix methodology in nuclear data research. This paper offers some perspective on the progress which has been made, on some of the unresolved problems, and on the potential yet to be realized. These discussions address a variety of issues related to the development of nuclear data. Topics examined are: the importance of designing and conducting experiments so that error information is conveniently generated; the procedures for identifying error sources and quantifying their magnitudes and correlations; the combination of errors; the importance of consistent and well-characterized measurementmore » standards; the role of covariances in data parameterization (fitting); the estimation of covariances for values calculated from mathematical models; the identification of abnormalities in covariance matrices and the analysis of their consequences; the problems encountered in representing covariance information in evaluated files; the role of covariances in the weighting of diverse data sets; the comparison of various evaluations; the influence of primary-data covariance in the analysis of covariances for derived quantities (sensitivity); and the role of covariances in the merging of the diverse nuclear data information. 226 refs., 2 tabs.« less

Questioning cochlear amplification

NASA Astrophysics Data System (ADS)

van der Heijden, Marcel; Versteegh, Corstiaen P. C.

2015-12-01

Thirty years ago it was hypothesized that motile processes inject mechanical energy into cochlear traveling waves. This mechanical amplification, alternatively described as negative damping, is invoked to explain both the sensitivity and the nonlinear compression of cochlear responses. There is a recent trend to present cochlear amplification as an established fact, even though the evidence is at most circumstantial and several thorny problems have remained unresolved. We analyze several of these issues, and present new basilar membrane recordings that allowed us to quantify cochlear energy flow. Specifically, we address the following questions: (1) Does auditory sensitivity require narrowband amplification? (2) Has the "RC problem" (lowpass filtering of outer hair cell receptor potential) been resolved? (3) Can OHC motility improve auditory sensitivity? (4) Is there a net power gain between neighboring locations on the basilar membrane? The analyses indicate that mechanical amplification in the cochlea is neither necessary nor useful, and that realizing it by known forms of motility would reduce sensitivity rather than enhance it. Finally, our experimental data show that the peaking of the traveling wave is realized by focusing the acoustic energy rather than amplifying it. (Abbreviations. BM: basilar membrane; CF: characteristic frequency; IHC: inner hair cell; ME: middle ear; MT; mechanotransducer; OHC: outer hair cell; SPL: sound pressure level.)

Drug crystallization - implications for topical and transdermal delivery.

PubMed

Hadgraft, Jonathan; Lane, Majella E

2016-06-01

Crystallization of actives in skin following topical application was suggested by studies in the 1950s and 1960s but is poorly understood. In contrast, the problem of crystallization of actives on skin and in transdermal formulations has been known for many years. With respect to crystallization in skin, this review describes early reports of a skin 'reservoir' and possible reasons underlying its genesis. Techniques to study crystallization on and in skin and in transdermal patches are outlined. The role of the vehicle in skin delivery is emphasised. Studies which have investigated permeation from crystalline particles are described. Approaches to limit crystallization of actives are discussed. Using supersaturation and antinuclean polymers, control of crystal size is possible; controlled release from crystals is also employed in transdermal patches. Drug crystallization has significant implications for topical and transdermal delivery. Approaches have been developed to counteract the issue for transdermal patches but crystallization in and on the skin for other formulations remains unresolved. Greater knowledge of residence time of excipients and their interaction with skin at the molecular level is critical in order to address the problem. This will lay the foundations for better design of topical/transdermal formulations.

TESTING WIND AS AN EXPLANATION FOR THE SPIN PROBLEM IN THE CONTINUUM-FITTING METHOD

DOE Office of Scientific and Technical Information (OSTI.GOV)

You, Bei; Czerny, Bożena; Sobolewska, Małgosia

2016-04-20

The continuum-fitting method is one of the two most advanced methods of determining the black hole spin in accreting X-ray binary systems. There are, however, still some unresolved issues with the underlying disk models. One of these issues manifests as an apparent decrease in spin for increasing source luminosity. Here, we perform a few simple tests to establish whether outflows from the disk close to the inner radius can address this problem. We employ four different parametric models to describe the wind and compare these to the apparent decrease in spin with luminosity measured in the sources LMC X-3 andmore » GRS 1915+105. Wind models in which parameters do not explicitly depend on the accretion rate cannot reproduce the spin measurements. Models with mass accretion rate dependent outflows, however, have spectra that emulate the observed ones. The assumption of a wind thus effectively removes the artifact of spin decrease. This solution is not unique; the same conclusion can be obtained using a truncated inner disk model. To distinguish among the valid models, we will need high-resolution X-ray data and a realistic description of the Comptonization in the wind.« less

Why does preferential diffusion strongly affect premixed turbulent combustion?

NASA Technical Reports Server (NTRS)

Kuznetsov, Vadim R.

1993-01-01

Combustion of premixed reactants in a turbulent flow is a classical but unresolved problem. The key problem is to explain the following data: the maximal turbulent and laminar burning velocities u(sub t) and u(sub L) occur at different equivalence ratios Phi. It is known that the equivalence ratio varies along a curved flame if molecular diffusivity D(sub fuel) does not equal D(sub oxygen). However, the mean flame radius of curvature is much larger than the laminar flame thickness delta-L. Therefore, significant influence of preferential diffusion should occur only if the flame propagation speed varies with flame curvature. This conclusion agrees with Zel'dovich's long-standing idea about the important role of leading points of a flame. The main objective of this paper is to prove Zel'dovich's hypothesis. An equation for the mean flame surface area density (MFSAD) is employed for this purpose. The second objective of this paper is to suggest a different approach to the derivation of the equation for MFSAD. It is based on the pdf equation for the reaction progress variable C and the relation between the pdf and MFSAD. This treatment suggests an entirely different closure assumption.

A view of the violence contained in chronic fatigue syndrome.

PubMed

Bennett, A

1997-04-01

In this paper I ask whether there might be any one particular psychopathology likely to be linked specifically with the physical illness known as chronic fatigue syndrome (CFS) or myalgic encephalomyelitis (ME), and whether CFS/ME aids and abets and "fits' an original mental state. I think the question cannot yet be answered. However it is my hypothesis that in some personality structures the onset of CFS/ ME following a physical illness exacerbates negativity and is an aspect of ordinary depression where there is a lowering of energy levels and a loss of zest for life, or it may reveal the pathological aspect of unresolved rage. Depending on the degree of pathological disturbance, working with and through the rage may or may not result in a resolution of the symptoms of ME. In this paper I consider some of the problems in the transference and countertransference relationship, which make it extremely difficult to separate out reality from phantasy. There is then the further problem of the denial of the psyche by the patient as part of the violence inherent in the illness. One case is presented, an example of ME in a borderline male patient in whom resolution could not be achieved.

Ultrafine particles in cities.

PubMed

Kumar, Prashant; Morawska, Lidia; Birmili, Wolfram; Paasonen, Pauli; Hu, Min; Kulmala, Markku; Harrison, Roy M; Norford, Leslie; Britter, Rex

2014-05-01

Ultrafine particles (UFPs; diameter less than 100 nm) are ubiquitous in urban air, and an acknowledged risk to human health. Globally, the major source for urban outdoor UFP concentrations is motor traffic. Ongoing trends towards urbanisation and expansion of road traffic are anticipated to further increase population exposure to UFPs. Numerous experimental studies have characterised UFPs in individual cities, but an integrated evaluation of emissions and population exposure is still lacking. Our analysis suggests that the average exposure to outdoor UFPs in Asian cities is about four-times larger than that in European cities but impacts on human health are largely unknown. This article reviews some fundamental drivers of UFP emissions and dispersion, and highlights unresolved challenges, as well as recommendations to ensure sustainable urban development whilst minimising any possible adverse health impacts. Copyright © 2014 Elsevier Ltd. All rights reserved.

Actin Out: Regulation of the Synaptic Cytoskeleton

PubMed Central

Spence, Erin F.; Soderling, Scott H.

2015-01-01

The small size of dendritic spines belies the elaborate role they play in excitatory synaptic transmission and ultimately complex behaviors. The cytoskeletal architecture of the spine is predominately composed of actin filaments. These filaments, which at first glance might appear simple, are also surprisingly complex. They dynamically assemble into different structures and serve as a platform for orchestrating the elaborate responses of the spine during spinogenesis and experience-dependent plasticity. Multiple mutations associated with human neurodevelopmental and psychiatric disorders involve genes that encode regulators of the synaptic cytoskeleton. A major, unresolved question is how the disruption of specific actin filament structures leads to the onset and progression of complex synaptic and behavioral phenotypes. This review will cover established and emerging mechanisms of actin cytoskeletal remodeling and how this influences specific aspects of spine biology that are implicated in disease. PMID:26453304

Exosome levels in human body fluids: A tumor marker by themselves?

PubMed

Cappello, Francesco; Logozzi, Mariantonia; Campanella, Claudia; Bavisotto, Celeste Caruso; Marcilla, Antonio; Properzi, Francesca; Fais, Stefano

2017-01-01

Despite considerable research efforts, the finding of reliable tumor biomarkers remains challenging and unresolved. In recent years a novel diagnostic biomedical tool with high potential has been identified in extracellular nanovesicles or exosomes. They are released by the majority of the cells and contain detailed molecular information on the cell of origin including tumor hallmarks. Exosomes can be isolated from easy accessible body fluids, and most importantly, they can provide several biomarkers, with different levels of specificity. Recent clinical evidence shows that the levels of exosomes released into body fluids may themselves represent a predictive/diagnostic of tumors, discriminating cancer patients from healthy subjects. The aim of this review is to highlight these latest challenging findings to provide novel and groundbreaking ideas for successful tumor early diagnosis and follow-up. Copyright © 2016 Elsevier B.V. All rights reserved.

Analysis of the Papal Benediction Sign: The ulnar neuropathy of St. Peter.

PubMed

Futterman, Bennett

2015-09-01

The origin of the Papal Benediction Sign has been a source of controversy for many generations of medical students. The question has been whether the Papal Benediction Sign posture is the result of an injury to the median nerve or to the ulnar nerve. The increasingly popular use of online "chat rooms" and the vast quantities of information available on the internet has led to an increasing level of confusion. Looking in major anatomy texts, anatomy and board review books as well as numerous internet sites the answer remains unresolved. Through the analysis of functional anatomy of the hand, cultural and religious practices of the early centuries of the Common Era and church art a clear answer emerges. It will become apparent that this hand posture results from an ulnar neuropathy. Copyright © 2015 Wiley Periodicals, Inc.

Juvenile honest food solicitation and parental investment as a life history strategy: A kin demographic selection model.

PubMed

Garay, József; Csiszár, Villő; Móri, Tamás F; Szilágyi, András; Varga, Zoltán; Számadó, Szabolcs

2018-01-01

Parent-offspring communication remains an unresolved challenge for biologist. The difficulty of the challenge comes from the fact that it is a multifaceted problem with connections to life-history evolution, parent-offspring conflict, kin selection and signalling. Previous efforts mainly focused on modelling resource allocation at the expense of the dynamic interaction during a reproductive season. Here we present a two-stage model of begging where the first stage models the interaction between nestlings and parents within a nest and the second stage models the life-history trade-offs. We show in an asexual population that honest begging results in decreased variance of collected food between siblings, which leads to mean number of surviving offspring. Thus, honest begging can be seen as a special bet-hedging against informational uncertainty, which not just decreases the variance of fitness but also increases the arithmetic mean.

Juvenile honest food solicitation and parental investment as a life history strategy: A kin demographic selection model

PubMed Central

Szilágyi, András; Varga, Zoltán

2018-01-01

Parent-offspring communication remains an unresolved challenge for biologist. The difficulty of the challenge comes from the fact that it is a multifaceted problem with connections to life-history evolution, parent-offspring conflict, kin selection and signalling. Previous efforts mainly focused on modelling resource allocation at the expense of the dynamic interaction during a reproductive season. Here we present a two-stage model of begging where the first stage models the interaction between nestlings and parents within a nest and the second stage models the life-history trade-offs. We show in an asexual population that honest begging results in decreased variance of collected food between siblings, which leads to mean number of surviving offspring. Thus, honest begging can be seen as a special bet-hedging against informational uncertainty, which not just decreases the variance of fitness but also increases the arithmetic mean. PMID:29494630

DOE Office of Scientific and Technical Information (OSTI.GOV)

Orange, N. Brice; Chesny, David L.; Gendre, Bruce

Solar variability investigations that include magnetic energy coupling are paramount to solving many key solar/stellar physics problems, particularly for understanding the temporal variability of magnetic energy redistribution and heating processes. Using three years of observations from the Solar Dynamics Observatory ’ s Atmospheric Imaging Assembly and Heliosemic Magnetic Imager, we measured radiative and magnetic fluxes from gross features and at full-disk scales, respectively. Magnetic energy coupling analyses support radiative flux descriptions via the plasma heating connectivity of dominant (magnetic) and diffuse components, specifically of the predominantly closed-field corona. Our work shows that this relationship favors an energetic redistribution efficiency acrossmore » large temperature gradients, and potentially sheds light on the long-standing issue of diffuse unresolved low corona emission. The close connection between magnetic energy redistribution and plasma conditions revealed by this work lends significant insight into the field of stellar physics, as we have provided possible means for probing distant sources in currently limited and/or undetectable radiation distributions.« less

[A French tool for evaluation of home palliative care: adaptation of the Support Team Assessment Schedule].

PubMed

Lagabrielle, D; Guyot, F; Jasso, G; Couturier, P; Poussin, G; Frossard, M; Szabo, P; Franco, A

2001-09-01

The authors describe the utilisation of a quality assessment tool for palliative care administered at home. The questionnaire entitled Support Team Assessment Schedule (STAS) was translated from English for this study. It was then utilised comparatively with different quality of life evaluation instruments. Only the results of the STAS are described here. The approach allows for the unresolved problems in the care to come to the surface week after week. The STAS comprises nine items pertaining to the patient and his/her family, and seven items concerning the services provided. The study exhibits the results of 107 evaluations completed from 50 patients stricken with cancer or AIDS in an advanced phase. The availability of this auto clinical audit tool, employable at home or in a hospital, constitutes an essential initial step in the field of French-speaking clinical evaluation of palliative care.

Some unresolved questions on hot-jet mixing control through artificial excitation

NASA Technical Reports Server (NTRS)

Ahuja, K. K.; Lepicovsky, J.; Brown, W. H.

1986-01-01

The problem of the mixing enhancement of heated jets through acoustic excitation is addressed using a 5.08 cm diameter jet operating at Mach numbers as high as 1.12 and at temperatures reaching 670 K. An experimental investigation is carried out to determine why high-speed heated jets are not as responsive to internal excitation as low-speed heated jets. Results are also presented which are related to the flow structure in the presence of screech and under the influence of external excitation. It is shown that, if sufficiently high excitation levels are used, the heated jets, even at high levels, can be modified by artificial excitation. Nonetheless, it is concluded that, for the test facility and test conditions used in the present study, the high-Mach-number heated jets are considerably less excitable than the similarly heated low-Mach-number jets.

The clinical role of the nurse teacher: a review of the dispute.

PubMed

Lee, D T

1996-06-01

Although clinical education has been acknowledged as being the 'heart' of all nursing education programmes, the role of the nurse teacher in relation to the clinical learning experience of the student nurse is an area of long-standing confusion and dispute. This unresolved problem has led to the lack of a concerted effort in the provision of educational input in the clinical area and the quality of patient care is indirectly being affected. This paper presents a comprehensive review of this dispute, with an attempt to unravel how the debate could be moved forward. It is found that the clinical role of the nurse teacher appears to be implicit and 'hidden', resulting in a wide difference in the interpretation of the extent, purpose and nature of that role. The controversies surrounding these issues were then traced and possible directions for future research are outlined.

Unresolved issues in mammalian fertilization.

PubMed

Olds-Clarke, Patricia

2003-01-01

This review considers the role of the sperm in fertilization, addressing areas of misunderstanding and unfounded assumptions and taking particular advantage of the large body of data resulting from work with rodent species in vitro. Considerable attention is given to the appropriate use and interpretation of assays for capacitation, acrosomal exocytosis, hyperactivation, and sperm protein phosphorylation, as well as tests for sperm-zona and sperm-oocyte membrane interactions. The lack of general agreement on the means of sperm adhesion to and penetration of the zona pellucida is addressed, and the need for new approaches to this problem is pointed out. Some molecular advances in our understanding of specific steps in the process of fertilization are discussed in the context of intact cell-matrix and cell-cell interaction. This review should provide practical information for researchers just beginning the study of fertilization and interesting but not widely known observations to stimulate new ideas in experienced scientists.

Spectrometry: Report of panel

NASA Technical Reports Server (NTRS)

Farmer, C. Barney; Murcray, David G.; Abreu, Vincent; Gille, John C.; Hanel, Rudolph A.; Hoell, James M., Jr.; Jamieson, John A.; Zwick, Harold

1987-01-01

Spectroscopic measurements are required to define the spectral background and provide the detailed spectral information that is essential for the design of species-specific systems and the analysis of data obtained from them. This function of spectroscopic measurements is expected to be an important part of any tropospheric remote-sensing program, and both emission and absorption spectroscopy are relevant in this context. The data from such observations are of value to tropospheric science in their own right, during the initial phases while species-specific techniques and instruments are under development. In addition, there are a number of unresolved problems in tropospheric radiative transfer and spectroscopy which presently limit the accuracy and reliability of all remote sensing methods. Only through a supporting program of spectroscopic measurements can progress be made in improving the understanding of these aspects of radiative transfer and ultimately reaching the desired confidence in the accuracy to species-specific monitoring techniques.

Flammability testing of 22 conventional European pediculicides.

PubMed

Dörge, Dorian D; Kuhn, Thomas; Klimpel, Sven

2017-04-01

Lice have been parasitizing humans for at least 10,000 years. Since then, humans have tried to rid themselves of these unpleasant and potentially disease-carrying insects. Despite various plant extracts and chemical compounds being used to combat recurring infestations to this date, several lice populations have developed resistance to some of the abundantly used compounds. This resulted in the development of anti-louse products that physically kill the different lice stages. Today, a widely used group of delousing agents are dimethicones (polydimethylsiloxane PDMS) which function by suffocating the lice. However, many dimethicones and related products are highly flammable which makes them potentially dangerous for treatment. In the present study, we tested the flammability of 22 delousing agents in order to shed some light onto this currently unresolved problem in the product design of pediculicides. Thirteen products were easily ignitable, some even by distant contact with a sparkler.

Ultra-sensitive pressure dependence of bandgap of rutile-GeO{sub 2} revealed by many body perturbation theory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Samanta, Atanu; Singh, Abhishek K.; Jain, Manish

2015-08-14

The reported values of bandgap of rutile GeO{sub 2} calculated by the standard density functional theory within local-density approximation (LDA)/generalized gradient approximation (GGA) show a wide variation (∼2 eV), whose origin remains unresolved. Here, we investigate the reasons for this variation by studying the electronic structure of rutile-GeO{sub 2} using many-body perturbation theory within the GW framework. The bandgap as well as valence bandwidth at Γ-point of rutile phase shows a strong dependence on volume change, which is independent of bandgap underestimation problem of LDA/GGA. This strong dependence originates from a change in hybridization among O-p and Ge-(s and p)more » orbitals. Furthermore, the parabolic nature of first conduction band along X-Γ-M direction changes towards a linear dispersion with volume expansion.« less

Heating of the Solar Corona and its Loops

NASA Technical Reports Server (NTRS)

Klimchuk, James A.

2009-01-01

At several million degrees, the solar corona is more than two orders of magnitude hotter than the underlying solar surface. The reason for these extreme conditions has been a puzzle for decades and is considered one of the fundamental problems in astrophysics. Much of the coronal plasma is organized by the magnetic field into arch-like structures called loops. Recent observational and theoretical advances have led to great progress in understanding the nature of these loops. In particular, we now believe they are bundles of unresolved magnetic strands that are heated by storms of impulsive energy bursts called nanoflares. Turbulent convection at the solar surface shuffles the footpoints of the strands and causes them to become tangled. A nanoflare occurs when the magnetic stresses reach a critical threshold, probably by way of a mechanism called the secondary instability. I will describe our current state of knowledge concerning the corona, its loops, and how they are heated.

CSF-1R Inhibitor Development: Current Clinical Status.

PubMed

Peyraud, Florent; Cousin, Sophie; Italiano, Antoine

2017-09-05

Colony-stimulating factor 1 receptor (CSF-1R) and its ligands, CSF-1 and interleukin 34 (IL-34), regulate the function and survival of tumor-associated macrophages, which are involved in tumorigenesis and in the suppression of antitumor immunity. Moreover, the CSF-1R/CSF-1 axis has been implicated in the pathogenesis of pigmented villonodular synovitis (PVNS), a benign tumor of the synovium. As advanced or metastatic malignant solid tumors and relapsed/refractory PVNS remain unresolved therapeutic problems, new approaches are needed to improve the outcome of patients with these conditions. In solid tumors, targeting CSF-1R via either small molecules or antibodies has shown interesting results in vitro but limited antitumor activity in vivo. Concerning PVNS, clinical trials assessing CSF-1R inhibitors have revealed promising initial outcomes. Blocking CSF-1/CSF-1R signaling represents a promising immunotherapy approach and several new potential combination therapies for future clinical testing.

Simulation of hypersonic scramjet exhaust. [pressure distribution on afterbody/nozzle sections of vehicle

NASA Technical Reports Server (NTRS)

Oman, R. A.; Foreman, K. M.; Leng, J.; Hopkins, H. B.

1975-01-01

A plan and some preliminary analysis for the accurate simulation of pressure distributions on the afterbody/nozzle portions of a hypersonic scramjet vehicle are described. The objectives fulfilled were to establish the standards of similitude for a hydrogen/air scramjet exhaust interacting with a vehicle afterbody, determine an experimental technique for validation of the procedures that will be used in conventional wind tunnel facilities, suggest a program of experiments for proof of the concept, and explore any unresolved problems in the proposed simulation procedures. It is shown that true enthalpy, Reynolds number, and nearly exact chemistry can be provided in the exhaust flow for the flight regime from Mach 4 to 10 by a detonation tube simulation. A detailed discussion of the required similarity parameters leads to the conclusion that substitute gases can be used as the simulated exhaust gas in a wind tunnel to achieve the correct interaction forces and moments.

Conceptual Challenges of the Systemic Approach in Understanding Cell Differentiation.

PubMed

Paldi, Andras

2018-01-01

The cells of a multicellular organism are derived from a single zygote and genetically identical. Yet, they are phenotypically very different. This difference is the result of a process commonly called cell differentiation. How the phenotypic diversity emerges during ontogenesis or regeneration is a central and intensely studied but still unresolved issue in biology. Cell biology is facing conceptual challenges that are frequently confused with methodological difficulties. How to define a cell type? What stability or change means in the context of cell differentiation and how to deal with the ubiquitous molecular variations seen in the living cells? What are the driving forces of the change? We propose to reframe the problem of cell differentiation in a systemic way by incorporating different theoretical approaches. The new conceptual framework is able to capture the insights made at different levels of cellular organization and considered previously as contradictory. It also provides a formal strategy for further experimental studies.

Challenges for Future UV Imaging of the Earth's Ionosphere and High Latitude Regions

NASA Technical Reports Server (NTRS)

Spann, James

2006-01-01

Large scale imaging of Geospace has played a significant role in the recent advances in the comprehension of the coupled Solar-Terrestrial System. The Earth's ionospheric far ultraviolet emissions provide a rich tapestry of observations that play a key role in sorting out the dominant mechanisms and phenomena associated with the coupling of the ionosphere and magnetosphere (MI). The MI coupling is an integral part of the Solar-Terrestrial and as such, future observations in this region should focus on understanding the coupling and the impact of solar variability. This talk will focus on the outstanding problems associated with the coupled Solar-Terrestrial system that can be best addressed using far ultraviolet imaging of the Earthls ionosphere. Challenges of global scale imaging and high-resolution imaging will be discussed and how these are driven by unresolved compelling science questions of magnetospheric configuration, and auroral dynamics.

Riemann Solvers in Relativistic Hydrodynamics: Basics and Astrophysical Applications

NASA Astrophysics Data System (ADS)

Ibanez, Jose M.

2001-12-01

My contribution to these proceedings summarizes a general overview on t High Resolution Shock Capturing methods (HRSC) in the field of relativistic hydrodynamics with special emphasis on Riemann solvers. HRSC techniques achieve highly accurate numerical approximations (formally second order or better) in smooth regions of the flow, and capture the motion of unresolved steep gradients without creating spurious oscillations. In the first part I will show how these techniques have been extended to relativistic hydrodynamics, making it possible to explore some challenging astrophysical scenarios. I will review recent literature concerning the main properties of different special relativistic Riemann solvers, and discuss several 1D and 2D test problems which are commonly used to evaluate the performance of numerical methods in relativistic hydrodynamics. In the second part I will illustrate the use of HRSC methods in several astrophysical applications where special and general relativistic hydrodynamical processes play a crucial role.

Measuring the Large-scale Solar Magnetic Field

NASA Astrophysics Data System (ADS)

Hoeksema, J. T.; Scherrer, P. H.; Peterson, E.; Svalgaard, L.

2017-12-01

The Sun's large-scale magnetic field is important for determining global structure of the corona and for quantifying the evolution of the polar field, which is sometimes used for predicting the strength of the next solar cycle. Having confidence in the determination of the large-scale magnetic field of the Sun is difficult because the field is often near the detection limit, various observing methods all measure something a little different, and various systematic effects can be very important. We compare resolved and unresolved observations of the large-scale magnetic field from the Wilcox Solar Observatory, Heliseismic and Magnetic Imager (HMI), Michelson Doppler Imager (MDI), and Solis. Cross comparison does not enable us to establish an absolute calibration, but it does allow us to discover and compensate for instrument problems, such as the sensitivity decrease seen in the WSO measurements in late 2016 and early 2017.

On the Interactions Between Planetary and Mesoscale Dynamics in the Oceans

NASA Astrophysics Data System (ADS)

Grooms, I.; Julien, K. A.; Fox-Kemper, B.

2011-12-01

Multiple-scales asymptotic methods are used to investigate the interaction of planetary and mesoscale dynamics in the oceans. We find three regimes. In the first, the slow, large-scale planetary flow sets up a baroclinically unstable background which leads to vigorous mesoscale eddy generation, but the eddy dynamics do not affect the planetary dynamics. In the second, the planetary flow feels the effects of the eddies, but appears to be unable to generate them. The first two regimes rely on horizontally isotropic large-scale dynamics. In the third regime, large-scale anisotropy, as exists for example in the Antarctic Circumpolar Current and in western boundary currents, allows the large-scale dynamics to both generate and respond to mesoscale eddies. We also discuss how the investigation may be brought to bear on the problem of parameterization of unresolved mesoscale dynamics in ocean general circulation models.

The Bosch process.

NASA Technical Reports Server (NTRS)

Meissner, H. P.; Reid, R. C.

1972-01-01

Many previous studies have been carried out to elucidate certain aspects of the Bosch process wherein CO2 is reacted over an iron catalyst to form carbon and water at temperatures around 1100 F. These results are assembled, and with the aid of new experimental data, are used to analyze the various reactions involved. It is shown that CO2 and H2 will not usually react to deposit carbon unless water is removed in a recycle loop. The critical importance of large catalyst areas is stressed relative to catalyst pretreatment processes. It is shown that in most operating Bosch reactions, mass transfer controls the rate of reaction, and it is suggested that the carbon filaments found are the expected result of such a rate limiting process. Typical recycle gas mixtures are considered, and maximum water yields are determined from various cases. A few suggestions are made to improve Bosch reaction performance, and a number of unresolved problems are noted.

Stationarity: Wanted dead or alive?

USGS Publications Warehouse

Lins, H.F.; Cohn, T.A.

2011-01-01

Aligning engineering practice with natural process behavior would appear, on its face, to be a prudent and reasonable course of action. However, if we do not understand the long-term characteristics of hydroclimatic processes, how does one find the prudent and reasonable course needed for water management? We consider this question in light of three aspects of existing and unresolved issues affecting hydroclimatic variability and statistical inference: Hurst-Kolmogorov phenomena; the complications long-term persistence introduces with respect to statistical understanding; and the dependence of process understanding on arbitrary sampling choices. These problems are not easily addressed. In such circumstances, humility may be more important than physics; a simple model with well-understood flaws may be preferable to a sophisticated model whose correspondence to reality is uncertain. ?? 2011 American Water Resources Association. This article is a U.S. Government work and is in the public domain in the USA.

Using mediation techniques to manage conflict and create healthy work environments.

PubMed

Gerardi, Debra

2004-01-01

Healthcare organizations must find ways for managing conflict and developing effective working relationships to create healthy work environments. The effects of unresolved conflict on clinical outcomes, staff retention, and the financial health of the organization lead to many unnecessary costs that divert resources from clinical care. The complexity of delivering critical care services makes conflict resolution difficult. Developing collaborative working relationships helps to manage conflict in complex environments. Working relationships are based on the ability to deal with differences. Dealing with differences requires skill development and techniques for balancing interests and communicating effectively. Techniques used by mediators are effective for resolving disputes and developing working relationships. With practice, these techniques are easily transferable to the clinical setting. Listening for understanding, reframing, elevating the definition of the problem, and forming clear agreements can foster working relationships, decrease the level of conflict, and create healthy work environments that benefit patients and professionals.

A country that never had a BSE crisis: consensus and tensions in transforming the Norwegian food system.

PubMed

Terragni, Laura

2006-09-01

Norway is often described as a country where the safety of domestically produced food is not questioned and where there is a prevailing consensus about the division of responsibility for food safety. For this reason it was surprising to find that Norwegian consumers trust the safety of their meat less than do their British counterparts. This result is particularly interesting, as Norway is one of the few countries that has never experienced BSE, while Britain has been the country most affected by it. The data discussed in the article suggest that not having to cope with a BSE crisis meant that some problems within the Norwegian food safety system remained unresolved. This in turn has affected patterns of consumer trust. The article is based on the data collected for a comparative study on European consumers' confidence in food safety.

Holding on to hope: A review of the literature exploring missing persons, hope and ambiguous loss.

PubMed

Wayland, Sarah; Maple, Myfanwy; McKay, Kathy; Glassock, Geoffrey

2016-01-01

When a person goes missing, those left behind mourn an ambiguous loss where grief can be disenfranchised. Different to bereavement following death, hope figures into this experience as a missing person has the potential to return. This review explores hope for families of missing people. Lived experience of ambiguous loss was deconstructed to reveal responses punctuated by hope, which had practical and psychological implications for those learning to live with an unresolved absence. Future lines of enquiry must address the dearth of research exploring the role of hope, unresolved grief, and its clinical implications when a person is missing.

New Gravity Wave Treatments for GISS Climate Models

NASA Technical Reports Server (NTRS)

Geller, Marvin A.; Zhou, Tiehan; Ruedy, Reto; Aleinov, Igor; Nazarenko, Larissa; Tausnev, Nikolai L.; Sun, Shan; Kelley, Maxwell; Cheng, Ye

2011-01-01

Previous versions of GISS climate models have either used formulations of Rayleigh drag to represent unresolved gravity wave interactions with the model-resolved flow or have included a rather complicated treatment of unresolved gravity waves that, while being climate interactive, involved the specification of a relatively large number of parameters that were not well constrained by observations and also was computationally very expensive. Here, the authors introduce a relatively simple and computationally efficient specification of unresolved orographic and nonorographic gravity waves and their interaction with the resolved flow. Comparisons of the GISS model winds and temperatures with no gravity wave parameterization; with only orographic gravity wave parameterization; and with both orographic and nonorographic gravity wave parameterizations are shown to illustrate how the zonal mean winds and temperatures converge toward observations. The authors also show that the specifications of orographic and nonorographic gravity waves must be different in the Northern and Southern Hemispheres. Then results are presented where the nonorographic gravity wave sources are specified to represent sources from convection in the intertropical convergence zone and spontaneous emission from jet imbalances. Finally, a strategy to include these effects in a climate-dependent manner is suggested.

A method for selecting M dwarfs with an increased likelihood of unresolved ultracool companionship

NASA Astrophysics Data System (ADS)

Cook, N. J.; Pinfield, D. J.; Marocco, F.; Burningham, B.; Jones, H. R. A.; Frith, J.; Zhong, J.; Luo, A. L.; Qi, Z. X.; Lucas, P. W.; Gromadzki, M.; Day-Jones, A. C.; Kurtev, R. G.; Guo, Y. X.; Wang, Y. F.; Bai, Y.; Yi, Z. P.; Smart, R. L.

2016-04-01

Locating ultracool companions to M dwarfs is important for constraining low-mass formation models, the measurement of substellar dynamical masses and radii, and for testing ultracool evolutionary models. We present an optimized method for identifying M dwarfs which may have unresolved ultracool companions. We construct a catalogue of 440 694 M dwarf candidates, from Wide-Field Infrared Survey Explorer, Two Micron All-Sky Survey and Sloan Digital Sky Survey, based on optical- and near-infrared colours and reduced proper motion. With strict reddening, photometric and quality constraints we isolate a subsample of 36 898 M dwarfs and search for possible mid-infrared M dwarf + ultracool dwarf candidates by comparing M dwarfs which have similar optical/near-infrared colours (chosen for their sensitivity to effective temperature and metallicity). We present 1082 M dwarf + ultracool dwarf candidates for follow-up. Using simulated ultracool dwarf companions to M dwarfs, we estimate that the occurrence of unresolved ultracool companions amongst our M dwarf + ultracool dwarf candidates should be at least four times the average for our full M dwarf catalogue. We discuss possible contamination and bias and predict yields of candidates based on our simulations.

A high-significance measurement of correlation between unresolved IRAS sources and optically-selected galaxy clusters

NASA Astrophysics Data System (ADS)

Hincks, Adam D.; Hajian, Amir; Addison, Graeme E.

2013-05-01

We cross-correlate the 100 μm Improved Reprocessing of the IRAS Survey (IRIS) map and galaxy clusters at 0.1 < z < 0.3 in the maxBCG catalogue taken from the Sloan Digital Sky Survey, measuring an angular cross-power spectrum over multipole moments 150 < l < 3000 at a total significance of over 40σ. The cross-spectrum, which arises from the spatial correlation between unresolved dusty galaxies that make up the cosmic infrared background (CIB) in the IRIS map and the galaxy clusters, is well-fit by a single power law with an index of -1.28±0.12, similar to the clustering of unresolved galaxies from cross-correlating far-infrared and submillimetre maps at longer wavelengths. Using a recent, phenomenological model for the spectral and clustering properties of the IRIS galaxies, we constrain the large-scale bias of the maxBCG clusters to be 2.6±1.4, consistent with existing analyses of the real-space cluster correlation function. The success of our method suggests that future CIB-optical cross-correlations using Planck and Herschel data will significantly improve our understanding of the clustering and redshift distribution of the faint CIB sources.

New Gravity Wave Treatments for GISS Climate Models

NASA Technical Reports Server (NTRS)

Geller, Marvin A.; Zhou, Tiehan; Ruedy, Reto; Aleinov, Igor; Nazarenko, Larissa; Tausnev, Nikolai L.; Sun, Shan; Kelley, Maxwell; Cheng, Ye

2010-01-01

Previous versions of GISS climate models have either used formulations of Rayleigh drag to represent unresolved gravity wave interactions with the model resolved flow or have included a rather complicated treatment of unresolved gravity waves that, while being climate interactive, involved the specification of a relatively large number of parameters that were not well constrained by observations and also was computationally very expensive. Here, we introduce a relatively simple and computationally efficient specification of unresolved orographic and non-orographic gravity waves and their interaction with the resolved flow. We show comparisons of the GISS model winds and temperatures with no gravity wave parametrization; with only orographic gravity wave parameterization; and with both orographic and non-orographic gravity wave parameterizations to illustrate how the zonal mean winds and temperatures converge toward observations. We also show that the specifications of orographic and nonorographic gravity waves must be different in the Northern and Southern Hemispheres. We then show results where the non-orographic gravity wave sources are specified to represent sources from convection in the Intertropical Convergence Zone and spontaneous emission from jet imbalances. Finally, we suggest a strategy to include these effects in a climate dependent manner.

The 3rd World Conference on Kisspeptin, "Kisspeptin 2017: Brain and Beyond":Unresolved questions, challenges and future directions for the field.

PubMed

Lehman, Michael N; Coolen, Lique M; Steiner, Robert A; Neal-Perry, Genevieve; Wang, Luhong; Moenter, Suzanne M; Moore, Aleisha M; Goodman, Robert L; Hwa-Yeo, Shel; Padilla, Stephanie L; Kauffman, Alexander S; Garcia, James; Kelly, Martin J; Clarkson, Jenny; Radovick, Sally; Babwah, Andy V; Leon, Silvia; Tena-Sempere, Manuel; Comninos, Alex; Seminara, Stephanie; Dhillo, Waljit S; Levine, Jon; Terasawa, Ei; Negron, Ariel; Herbison, Allan E

2018-04-14

The 3 rd World Conference on Kisspeptin, "Kisspeptin 2017: Brain and Beyond" was held March 30-31 at the Rosen Centre Hotel in Orlando, Florida, providing an international forum for multidisciplinary scientists to meet and share cutting-edge research on kisspeptin biology and its relevance to human health and disease. The meeting built upon previous world conferences focused on the role of kisspeptin and associated peptides in the control of gonadotropin-releasing hormone (GnRH) secretion and reproduction. Based on recent discoveries, the scope of this meeting was expanded to include functions of kisspeptin and related peptides in other physiological systems including energy homeostasis, pregnancy, ovarian and uterine function, and thermoregulation. In addition, discussions addressed the translation of basic knowledge of kisspeptin biology to the treatment of disease, with the goal of seeking consensus about the best approaches to improve human health. The two-day meeting featured a non-traditional structure, with each day starting with poster sessions followed by lunch discussions and facilitated large-group sessions with short presentations to maximize the exchange of new, unpublished data. Topics were identified by a survey prior to the meeting, and focused on major unresolved questions, important controversies, and future directions in the field. Finally, career development activities provided mentoring for trainees and junior investigators, and networking opportunities for those individuals with established researchers in the field. Overall, the meeting was rated as a success by attendees and covered a wide range of lively and provocative discussion topics on the changing nature of the field of "kisspeptinology" and its future. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

Hybridization among distantly related species: Examples from the polyploid genus Curcuma (Zingiberaceae).

PubMed

Záveská, Eliška; Fér, Tomáš; Šída, Otakar; Marhold, Karol; Leong-Škorničková, Jana

2016-07-01

Discerning relationships among species evolved by reticulate and/or polyploid evolution is not an easy task, although it is widely discussed. The economically important genus Curcuma (ca. 120 spp.; Zingiberaceae), broadly distributed in tropical SE Asia, is a particularly interesting example of a group of palaeopolyploid origin whose evolution is driven mainly by hybridization and polyploidization. Although a phylogeny and a new infrageneric classification of Curcuma, based on commonly used molecular markers (ITS and cpDNA), have recently been proposed, significant evolutionary questions remain unresolved. We applied a multilocus approach and a combination of modern analytical methods to this genus to distinguish causes of gene tree incongruence and to identify hybrids and their parental species. Five independent regions of nuclear DNA (DCS, GAPDH, GLOBOSA3, LEAFY, ITS) and four non-coding cpDNA regions (trnL-trnF, trnT-trnL, psbA-trnH and matK), analysed as a single locus, were employed to construct a species tree and hybrid species trees using (*)BEAST and STEM-hy. Detection of hybridogenous species in the dataset was also conducted using the posterior predictive checking approach as implemented in JML. The resulting species tree outlines the relationships among major evolutionary lineages within Curcuma, which were previously unresolved or which conflicted depending upon whether they were based on ITS or cpDNA markers. Moreover, by using the additional markers in tests of plausible topologies of hybrid species trees for C. vamana, C. candida, C. roscoeana and C. myanmarensis suggested by previous molecular and morphological evidence, we found strong evidence that all the species except C. candida are of subgeneric hybrid origin. Copyright © 2016 Elsevier Inc. All rights reserved.

Practical problems in aggregating expert opinions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Booker, J.M.; Picard, R.R.; Meyer, M.A.

1993-11-01

Expert opinion is data given by a qualified person in response to a technical question. In these analyses, expert opinion provides information where other data are either sparse or non-existent. Improvements in forecasting result from the advantageous addition of expert opinion to observed data in many areas, such as meteorology and econometrics. More generally, analyses of large, complex systems often involve experts on various components of the system supplying input to a decision process; applications include such wide-ranging areas as nuclear reactor safety, management science, and seismology. For large or complex applications, no single expert may be knowledgeable enough aboutmore » the entire application. In other problems, decision makers may find it comforting that a consensus or aggregation of opinions is usually better than a single opinion. Many risk and reliability studies require a single estimate for modeling, analysis, reporting, and decision making purposes. For problems with large uncertainties, the strategy of combining as diverse a set of experts as possible hedges against underestimation of that uncertainty. Decision makers are frequently faced with the task of selecting the experts and combining their opinions. However, the aggregation is often the responsibility of an analyst. Whether the decision maker or the analyst does the aggregation, the input for it, such as providing weights for experts or estimating other parameters, is imperfect owing to a lack of omniscience. Aggregation methods for expert opinions have existed for over thirty years; yet many of the difficulties with their use remain unresolved. The bulk of these problem areas are summarized in the sections that follow: sensitivities of results to assumptions, weights for experts, correlation of experts, and handling uncertainties. The purpose of this paper is to discuss the sources of these problems and describe their effects on aggregation.« less

Dissipative closures for statistical moments, fluid moments, and subgrid scales in plasma turbulence

NASA Astrophysics Data System (ADS)

Smith, Stephen Andrew

1997-11-01

Closures are necessary in the study physical systems with large numbers of degrees of freedom when it is only possible to compute a small number of modes. The modes that are to be computed, the resolved modes, are coupled to unresolved modes that must be estimated. This thesis focuses on dissipative closures models for two problems that arises in the study of plasma turbulence: the fluid moment closure problem and the subgrid scale closure problem. The fluid moment closures of Hammett and Perkins (1990) were originally applied to a one-dimensional kinetic equation, the Vlasov equation. These closures are generalized in this thesis and applied to the stochastic oscillator problem, a standard paradigm problem for statistical closures. The linear theory of the Hammett- Perkins closures is shown to converge with increasing numbers of moments. A novel parameterized hyperviscosity is proposed for two- dimensional drift-wave turbulence. The magnitude and exponent of the hyperviscosity are expressed as functions of the large scale advection velocity. Traditionally hyperviscosities are applied to simulations with a fixed exponent that must be arbitrarily chosen. Expressing the exponent as a function of the simulation parameters eliminates this ambiguity. These functions are parameterized by comparing the hyperviscous dissipation to the subgrid dissipation calculated from direct numerical simulations. Tests of the parameterization demonstrate that it performs better than using no additional damping term or than using a standard hyperviscosity. Heuristic arguments are presented to extend this hyperviscosity model to three-dimensional (3D) drift-wave turbulence where eddies are highly elongated along the field line. Preliminary results indicate that this generalized 3D hyperviscosity is capable of reducing the resolution requirements for 3D gyrofluid turbulence simulations.

Second-hand smoke exposure in 4-year-old children in Spain: Sources, associated factors and urinary cotinine.

PubMed

Aurrekoetxea, Juan José; Murcia, Mario; Rebagliato, Marisa; Guxens, Mònica; Fernández-Somoano, Ana; López, María José; Lertxundi, Aitana; Castilla, Ane Miren; Espada, Mercedes; Tardón, Adonina; Ballester, Ferran; Santa-Marina, Loreto

2016-02-01

Second-hand smoke exposure (SHS) in children remains as a major pollution problem, with important consequences for children's health. This study aimed to identify the sources of exposure to SHS among 4-year-old children, comparing self-reports to a urinary biomarker of exposure, and characterize the most important variables related to SHS exposure in this population. 4-year-old children's exposure to SHS was assessed by a parental-reported questionnaire and by urinary cotinine (UC) measurements in 1757 participants from 4 different areas of the Spanish INMA (INfancia y Medio Ambiente - Environment and Childhood) Project. The questionnaire about SHS included information about smoking habits at home by household members, and about exposure to SHS in other places including other homes, bars, restaurants or transportation. The association between quantified UC levels (>4ng/ml) and sociodemographic variables and the different sources of SHS exposure was examined using logistic regression. Based on parental reports, 21.6% of the children were exposed to SHS at home and 47.1% elsewhere; making a total 55.9% of the children exposed to SHS. In addition, 28.2% of the children whose parents reported being not regularly exposed to SHS had quantified UC values. Children from younger mothers (<34 vs. ≥39.4 y) had a higher odds of exposure to SHS [OR (95% CI): 2.28 (1.70-3.05) per year], as well as from families with a lower educational level [OR secondary: 2.12 (1.69-2.65); primary or less: 2.91 (2.19-3.88)]. The odds of quantifiable UC in children dropped after the smoking ban in public places [OR=0.59 (0.42-0.83)]. Regarding the sources of SHS exposure we observed that quantifiable UC odds was increased in children whose parents smoked at home in their presence [OR mother occasionally: 13.39 (7.03-25.50); mother often: 18.48 (8.40-40.66); father occasionally: 10.98 (6.52-18.49); father often: 11.50 (5.96-22.20)] or in children attending other confined places, mainly other houses where people smoked [OR: 2.23 (1.78-2.80)]. Children's SHS exposure is nowadays an unresolved major public health problem in Spain. After the ban of smoking in public places health care professionals should put more emphasis to the parents on the importance of controlling the exposure of their children in private spaces. Copyright © 2015 Elsevier Inc. All rights reserved.

HUMeral shaft fractures: measuring recovery after operative versus non-operative treatment (HUMMER): a multicenter comparative observational study.

PubMed

Mahabier, Kiran C; Van Lieshout, Esther M M; Bolhuis, Hugo W; Bos, P Koen; Bronkhorst, Maarten Wga; Bruijninckx, Milko M M; De Haan, Jeroen; Deenik, Axel R; Dwars, Boudewijn J; Eversdijk, Martin G; Goslings, J Carel; Haverlag, Robert; Heetveld, Martin J; Kerver, Albert J H; Kolkman, Karel A; Leenhouts, Peter A; Meylaerts, Sven A G; Onstenk, Ron; Poeze, Martijn; Poolman, Rudolf W; Punt, Bas J; Roerdink, W Herbert; Roukema, Gert R; Sintenie, Jan Bernard; Soesman, Nicolaj M R; Tanka, Andras K F; Ten Holder, Edgar J T; Van der Elst, Maarten; Van der Heijden, Frank H W M; Van der Linden, Frits M; Van der Zwaal, Peer; Van Dijk, Jan P; Van Jonbergen, Hans-Peter W; Verleisdonk, Egbert J M M; Vroemen, Jos P A M; Waleboer, Marco; Wittich, Philippe; Zuidema, Wietse P; Polinder, Suzanne; Verhofstad, Michael H J; Den Hartog, Dennis

2014-02-11

Fractures of the humeral shaft are associated with a profound temporary (and in the elderly sometimes even permanent) impairment of independence and quality of life. These fractures can be treated operatively or non-operatively, but the optimal tailored treatment is an unresolved problem. As no high-quality comparative randomized or observational studies are available, a recent Cochrane review concluded there is no evidence of sufficient scientific quality available to inform the decision to operate or not. Since randomized controlled trials for this injury have shown feasibility issues, this study is designed to provide the best achievable evidence to answer this unresolved problem. The primary aim of this study is to evaluate functional recovery after operative versus non-operative treatment in adult patients who sustained a humeral shaft fracture. Secondary aims include the effect of treatment on pain, complications, generic health-related quality of life, time to resumption of activities of daily living and work, and cost-effectiveness. The main hypothesis is that operative treatment will result in faster recovery. The design of the study will be a multicenter prospective observational study of 400 patients who have sustained a humeral shaft fracture, AO type 12A or 12B. Treatment decision (i.e., operative or non-operative) will be left to the discretion of the treating surgeon. Critical elements of treatment will be registered and outcome will be monitored at regular intervals over the subsequent 12 months. The primary outcome measure is the Disabilities of the Arm, Shoulder, and Hand score. Secondary outcome measures are the Constant score, pain level at both sides, range of motion of the elbow and shoulder joint at both sides, radiographic healing, rate of complications and (secondary) interventions, health-related quality of life (Short-Form 36 and EuroQol-5D), time to resumption of ADL/work, and cost-effectiveness. Data will be analyzed using univariate and multivariable analyses (including mixed effects regression analysis). The cost-effectiveness analysis will be performed from a societal perspective. Successful completion of this trial will provide evidence on the effectiveness of operative versus non-operative treatment of patients with a humeral shaft fracture. The trial is registered at the Netherlands Trial Register (NTR3617).

Determining paths by which farmers can adapt effectively to scarce freshwater resources

NASA Astrophysics Data System (ADS)

Watson, R.; Hornberger, G.; Carrico, A. R.

2012-12-01

Stress on freshwater resources is a significant risk associated with climatic change. The risk is even greater given the expected changes in overall resource use as the developing world develops, as the world's population continues to grow, and as land use changes dramatically. Effective water management has implications for food security, health, and political stability worldwide. This is particularly true in developing regions heavily dependent on agriculture, and where agriculture depends on irrigation. Adaptation to water stress requires both managing water allocation among competing users and ensuring that each user is efficient in his or her use of a limited allotment: the problem is a quintessential common-pool resource (CPR) dilemma. In the future even more so than in the past, adaptation will be essential as the world evolves. The problem that we identify—determining paths by which farmers can adapt effectively to increasingly scarce freshwater resources—is one of great scientific and societal importance. The issue lies at the intersection of water-cycle processes and social-psychological processes that influence and are influenced by water availability and use. This intersection harbors intriguing unresolved scientific questions; advances in natural and social sciences will stem from attacks on the overall problem. The issue is societally compelling because the ability of the world to supply adequate food for a population expected to grow to over 9 billion by 2050 may well be determined by how farmers, consumers, and government institutions adapt to changing conditions of water availability. Major strides have been made in recent decades in understanding why Hardin's envisioned "tragedy of the commons" is avoided under certain circumstances, in some cases through self-organization rather than government intervention originally considered a necessity. Furthermore, we now know that the impacts of decisions about allocation and use of water can be amplified by human system-natural system feedbacks. Thus, although there are hard problems in many individual disciplines to be tackled, it is also clear that CPR problems cannot be understood, much less managed, without truly interdisciplinary approaches that recognize that human and natural systems are strongly coupled and that include this coupling in the research design and implementation. The problem of farmer adaptation is a specific instance of the challenge articulated by Ostrom in her Nobel Prize lecture: "We thus face the tough task of further developing our theories to help understand and predict when those involved in a common-pool resource dilemma will be able to self-organize and how various aspects of the broad context they face affect their strategies, the short-term success of their efforts, and the long-term robustness of their initial achievements." In this paper we discuss advances in recent understanding of irrigation water as a CPR and the linkages with individual behavior. Using our ongoing work in Sri Lanka to provide context, we also discuss gaps in this research as well as emerging problems warranting attention. We pay special attention to the role and necessity of integrated, interdisciplinary research and identify a framework for making further progress toward addressing the key problem of determining paths by which farmers can adapt effectively.

New Methods in Non-Perturbative QCD

DOE Office of Scientific and Technical Information (OSTI.GOV)

Unsal, Mithat

2017-01-31

In this work, we investigate the properties of quantum chromodynamics (QCD), by using newly developing mathematics and physics formalisms. Almost all of the mass in the visible universe emerges from a quantum chromodynamics (QCD), which has a completely negligible microscopic mass content. An intimately related issue in QCD is the quark confinement problem. Answers to non-perturbative questions in QCD remained largely elusive despite much effort over the years. It is also believed that the usual perturbation theory is inadequate to address these kinds of problems. Perturbation theory gives a divergent asymptotic series (even when the theory is properly renormalized), andmore » there are non-perturbative phenomena which never appear at any order in perturbation theory. Recently, a fascinating bridge between perturbation theory and non-perturbative effects has been found: a formalism called resurgence theory in mathematics tells us that perturbative data and non-perturbative data are intimately related. Translating this to the language of quantum field theory, it turns out that non-perturbative information is present in a coded form in perturbation theory and it can be decoded. We take advantage of this feature, which is particularly useful to understand some unresolved mysteries of QCD from first principles. In particular, we use: a) Circle compactifications which provide a semi-classical window to study confinement and mass gap problems, and calculable prototypes of the deconfinement phase transition; b) Resurgence theory and transseries which provide a unified framework for perturbative and non-perturbative expansion; c) Analytic continuation of path integrals and Lefschetz thimbles which may be useful to address sign problem in QCD at finite density.« less

Assessment of Hybrid RANS/LES Turbulence Models for Aeroacoustics Applications

NASA Technical Reports Server (NTRS)

Vatsa, Veer N.; Lockard, David P.

2010-01-01

Predicting the noise from aircraft with exposed landing gear remains a challenging problem for the aeroacoustics community. Although computational fluid dynamics (CFD) has shown promise as a technique that could produce high-fidelity flow solutions, generating grids that can resolve the pertinent physics around complex configurations can be very challenging. Structured grids are often impractical for such configurations. Unstructured grids offer a path forward for simulating complex configurations. However, few unstructured grid codes have been thoroughly tested for unsteady flow problems in the manner needed for aeroacoustic prediction. A widely used unstructured grid code, FUN3D, is examined for resolving the near field in unsteady flow problems. Although the ultimate goal is to compute the flow around complex geometries such as the landing gear, simpler problems that include some of the relevant physics, and are easily amenable to the structured grid approaches are used for testing the unstructured grid approach. The test cases chosen for this study correspond to the experimental work on single and tandem cylinders conducted in the Basic Aerodynamic Research Tunnel (BART) and the Quiet Flow Facility (QFF) at NASA Langley Research Center. These configurations offer an excellent opportunity to assess the performance of hybrid RANS/LES turbulence models that transition from RANS in unresolved regions near solid bodies to LES in the outer flow field. Several of these models have been implemented and tested in both structured and unstructured grid codes to evaluate their dependence on the solver and mesh type. Comparison of FUN3D solutions with experimental data and numerical solutions from a structured grid flow solver are found to be encouraging.

Microplate model for the present-day deformation of Tibet

USGS Publications Warehouse

Thatcher, W.

2007-01-01

Site velocities from 349 Global Positioning System (GPS) stations are used to construct an 11-element quasi-rigid block model of the Tibetan Plateau and its surroundings. Rigid rotations of five major blocks are well determined, and average translation velocities of six smaller blocks can be constrained. Where data are well distributed the velocity field can be explained well by rigid block motion and fault slip across block boundaries. Residual misfits average 1.6 mm/yr compared to typical one standard deviation velocity uncertainties of 1.3 mm/yr. Any residual internal straining of the blocks is small and heterogeneous. However, residual substructure might well represent currently unresolved motions of smaller blocks. Although any smaller blocks must move at nearly the same rate as the larger blocks within which they lie, undetected relative motions between them could be significant, particularly where there are gaps in GPS coverage. Predicted relative motions between major blocks agree with the observed sense of slip and along-strike partitioning of motion across major faults. However, predicted slip rates across Tibet's major strike-slip faults are low, only 5-12 mm/yr, a factor of 2-3 smaller than most rates estimated from fault offset features dated by radiometric methods as ???2000 to ???100,000 year old. Previous work has suggested that both GPS data and low fault slip rates are incompatible with rigid block motions of Tibet. The results reported here overcome these objections.

Electron-impact electronic-state excitation of para-benzoquinone

NASA Astrophysics Data System (ADS)

Jones, D. B.; da Costa, R. F.; Kossoski, F.; Varella, M. T. do N.; Bettega, M. H. F.; Ferreira da Silva, F.; Limão-Vieira, P.; García, G.; Lima, M. A. P.; White, R. D.; Brunger, M. J.

2018-03-01

Angle resolved electron energy loss spectra (EELS) for para-benzoquinone (C6H4O2) have been recorded for incident electron energies of 20, 30, and 40 eV. Measured differential cross sections (DCSs) for electronic band features, composed of a combination of energetically unresolved electronic states, are subsequently derived from those EELS. Where possible, the obtained DCSs are compared with those calculated using the Schwinger multichannel method with pseudopotentials. These calculations were performed using a minimum orbital basis single configuration interaction framework at the static exchange plus polarisation level. Here, quite reasonable agreement between the experimental cross sections and the theoretical cross sections for the summation of unresolved states was observed.

"Unresolved Complex Mixture" (UCM): A brief history of the term and moving beyond it.

PubMed

Farrington, John W; Quinn, James G

2015-07-15

The term "Unresolved Complex Mixture" (UCM) has been used extensively for decades to describe a gas chromatographic characteristic indicative of the presence of fossil fuel hydrocarbons (mainly petroleum hydrocarbons) in hydrocarbons isolated from aquatic samples. We chronicle the origin of the term. While it is still a useful characteristic for screening samples, more modern higher resolution two dimensional gas chromatography and gas chromatography coupled with advanced mass spectrometry techniques (Time-of-Flight or Fourier Transform-Ion Cyclotron Resonance) should be employed for analyses of petroleum contaminated samples. This will facilitate advances in understanding of the origins, fates and effects of petroleum compounds in aquatic environments. Copyright © 2015 Elsevier Ltd. All rights reserved.

Temporal behavior of unresolved transition array emission in water window soft x-ray spectral region from multiply charged ions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dinh, Thanh-Hung, E-mail: dinh@cc.utsunomiya-u.ac.jp; Suzuki, Yuhei; Arai, Goki

2015-09-21

We have characterized the spectral structure and the temporal history of the laser-produced high-Z multi-charged ion plasmas for the efficient water window soft x-ray sources. Strong unresolved transition array emission was observed due to 4d–4f and 4f–5g transitions from Au, Pb, and Bi plasmas in the 280–700 eV photon energy region. The temporal behavior of the emission was essentially similar of that of the laser pulse with a slight delay between different transitions. These results provide feedback for accurate modeling of the atomic processes with the radiative hydrodynamic simulations.

Beacons in the dark: using the most distant galaxies to probe cosmic reionization

NASA Astrophysics Data System (ADS)

De Barros, Stephane

2017-08-01

One of the major unresolved problems in modern cosmology is when and how the universe was ionized. The consensus scenario is that ultra-faint, low-mass galaxies contributed most to the UV background at high-redshift and that reionization was an inhomogeneous process, with ionized bubbles created first around galaxy overdensities. The very surprising discovery of Ly-alpha emission lines around a large fraction of the most luminous galaxies at z=7.4-8.7, when we expect the universe to be highly neutral, could thus be explained by the fact that they lie in large HII bubbles which were ionized thanks to yet undetected fainter neighbors. Theoretical models indeed predict a boost of up to 6x larger galaxy counts around the brightest sources compared to the general field, when probing down to luminosities as faint as 0.1L_UV of the central source. Here we propose a direct test of these models by searching for fainter neighbors around three bright z>7.4 galaxies emitting Ly-alpha, including two sources that lie only 9 Mpc from each other and could share the same ionized bubble, as well as the most distant confirmed Ly-alpha emitter EGSY-8p7 at z=8.68. Given the expected overdensities, we have the opportunity to detect 20 (and up to 50) new z 7-9 galaxies with only a modest investment of HST time. These observations are thus maximally efficient at providing a large number of precious high-redshift targets for early JWST spectroscopy to directly study the galaxies that are in the process of ionizing the universe. Our imaging will further enhance the legacy of the CANDELS/EGS field, and we will make the reduced data available to the community immediately for JWST follow-up.

Implementing a pilot work injury management program in Hong Kong.

PubMed

Lai, Hon-Sun; Chan, Chetwyn C H

2007-12-01

This paper reports the results of implementing a pilot case management system for work injuries in Hong Kong. The case management approach was characterized by use of a case manager who worked closely with each of the reported injury cases. The case manager undertook the roles of assessor, referral agent, counselor, work-site liaison, and return-to-work (RTW) expert. A quasi-experimental study design was used. The study compared the RTW and workers' compensation outcomes in injured workers in a cleaning company in a case management group (n = 296) and a conventional rehabilitation group (n = 137). Outcomes of the intervention were followed up at 6 months. The results indicated that the RTW rate was 97.0% and 94.2% for the case management and conventional rehabilitation groups respectively, with no significant differences between them. Participants in the case management group had significantly fewer days of sick leave (mean = 27.5 and 41.6 days, respectively) and lower compensation costs (mean = HK$7,212.2 and $20,617.3, respectively) than those in the comparison group. Age of the participants was found to influence the outcomes with those who were between 41 and 50 years old and received case management intervention had shorter sick leave and lower cost of compensation than their conventional rehabilitation counterpart. The majority of the participants who had returned to work in both the case management (95.8%) and the conventional rehabilitation (96.2%) groups were found to maintain their work status 6 months after the intervention. The findings suggested that applying the case management approach to the Hong Kong workers' compensation system was more effective overall. Nevertheless, the inherent problems associated with implementing such an approach within the existing system, which focuses on compensation and medical interventions, remained unresolved.

Systems biology of cisplatin resistance: past, present and future.

PubMed

Galluzzi, L; Vitale, I; Michels, J; Brenner, C; Szabadkai, G; Harel-Bellan, A; Castedo, M; Kroemer, G

2014-05-29

The platinum derivative cis-diamminedichloroplatinum(II), best known as cisplatin, is currently employed for the clinical management of patients affected by testicular, ovarian, head and neck, colorectal, bladder and lung cancers. For a long time, the antineoplastic effects of cisplatin have been fully ascribed to its ability to generate unrepairable DNA lesions, hence inducing either a permanent proliferative arrest known as cellular senescence or the mitochondrial pathway of apoptosis. Accumulating evidence now suggests that the cytostatic and cytotoxic activity of cisplatin involves both a nuclear and a cytoplasmic component. Despite the unresolved issues regarding its mechanism of action, the administration of cisplatin is generally associated with high rates of clinical responses. However, in the vast majority of cases, malignant cells exposed to cisplatin activate a multipronged adaptive response that renders them less susceptible to the antiproliferative and cytotoxic effects of the drug, and eventually resume proliferation. Thus, a large fraction of cisplatin-treated patients is destined to experience therapeutic failure and tumor recurrence. Throughout the last four decades great efforts have been devoted to the characterization of the molecular mechanisms whereby neoplastic cells progressively lose their sensitivity to cisplatin. The advent of high-content and high-throughput screening technologies has accelerated the discovery of cell-intrinsic and cell-extrinsic pathways that may be targeted to prevent or reverse cisplatin resistance in cancer patients. Still, the multifactorial and redundant nature of this phenomenon poses a significant barrier against the identification of effective chemosensitization strategies. Here, we discuss recent systems biology studies aimed at deconvoluting the complex circuitries that underpin cisplatin resistance, and how their findings might drive the development of rational approaches to tackle this clinically relevant problem.

Recent advancements in liposomes targeting strategies to cross blood-brain barrier (BBB) for the treatment of Alzheimer's disease.

PubMed

Agrawal, Mukta; Ajazuddin; Tripathi, Dulal K; Saraf, Swarnlata; Saraf, Shailendra; Antimisiaris, Sophia G; Mourtas, Spyridon; Hammarlund-Udenaes, Margareta; Alexander, Amit

2017-08-28

In this modern era, with the help of various advanced technologies, medical science has overcome most of the health-related issues successfully. Though, some diseases still remain unresolved due to various physiological barriers. One such condition is Alzheimer; a neurodegenerative disorder characterized by progressive memory impairment, behavioral abnormalities, mood swing and disturbed routine activities of the person suffering from. It is well known to all that the brain is entirely covered by a protective layer commonly known as blood brain barrier (BBB) which is responsible to maintain the homeostasis of brain by restricting the entry of toxic substances, drug molecules, various proteins and peptides, small hydrophilic molecules, large lipophilic substances and so many other peripheral components to protect the brain from any harmful stimuli. This functionally essential structure creates a major hurdle for delivery of any drug into the brain. Still, there are some provisions on BBB which facilitate the entry of useful substances in the brain via specific mechanisms like passive diffusion, receptor-mediated transcytosis, carrier-mediated transcytosis etc. Another important factor for drug transport is the selection of a suitable drug delivery systems like, liposome, which is a novel drug carrier system offering a potential approach to resolving this problem. Its unique phospholipid bilayer structure (similar to physiological membrane) had made it more compatible with the lipoidal layer of BBB and helps the drug to enter the brain. The present review work focused on various surface modifications with functional ligand (like lactoferrin, transferrin etc.) and carrier molecules (such as glutathione, glucose etc.) on the liposomal structure to enhance its brain targeting ability towards the successful treatment of Alzheimer disease. Copyright © 2017 Elsevier B.V. All rights reserved.

Systems biology of cisplatin resistance: past, present and future

PubMed Central

Galluzzi, L; Vitale, I; Michels, J; Brenner, C; Szabadkai, G; Harel-Bellan, A; Castedo, M; Kroemer, G

2014-01-01

The platinum derivative cis-diamminedichloroplatinum(II), best known as cisplatin, is currently employed for the clinical management of patients affected by testicular, ovarian, head and neck, colorectal, bladder and lung cancers. For a long time, the antineoplastic effects of cisplatin have been fully ascribed to its ability to generate unrepairable DNA lesions, hence inducing either a permanent proliferative arrest known as cellular senescence or the mitochondrial pathway of apoptosis. Accumulating evidence now suggests that the cytostatic and cytotoxic activity of cisplatin involves both a nuclear and a cytoplasmic component. Despite the unresolved issues regarding its mechanism of action, the administration of cisplatin is generally associated with high rates of clinical responses. However, in the vast majority of cases, malignant cells exposed to cisplatin activate a multipronged adaptive response that renders them less susceptible to the antiproliferative and cytotoxic effects of the drug, and eventually resume proliferation. Thus, a large fraction of cisplatin-treated patients is destined to experience therapeutic failure and tumor recurrence. Throughout the last four decades great efforts have been devoted to the characterization of the molecular mechanisms whereby neoplastic cells progressively lose their sensitivity to cisplatin. The advent of high-content and high-throughput screening technologies has accelerated the discovery of cell-intrinsic and cell-extrinsic pathways that may be targeted to prevent or reverse cisplatin resistance in cancer patients. Still, the multifactorial and redundant nature of this phenomenon poses a significant barrier against the identification of effective chemosensitization strategies. Here, we discuss recent systems biology studies aimed at deconvoluting the complex circuitries that underpin cisplatin resistance, and how their findings might drive the development of rational approaches to tackle this clinically relevant problem. PMID:24874729

Evolution of Space Dependent Growth in the Teleost Astyanax mexicanus

PubMed Central

Gallo, Natalya D.; Jeffery, William R.

2012-01-01

The relationship between growth rate and environmental space is an unresolved issue in teleosts. While it is known from aquaculture studies that stocking density has a negative relationship to growth, the underlying mechanisms have not been elucidated, primarily because the growth rate of populations rather than individual fish were the subject of all previous studies. Here we investigate this problem in the teleost Astyanax mexicanus, which consists of a sighted surface-dwelling form (surface fish) and several blind cave-dwelling (cavefish) forms. Surface fish and cavefish are distinguished by living in spatially contrasting environments and therefore are excellent models to study the effects of environmental size on growth. Multiple controlled growth experiments with individual fish raised in confined or unconfined spaces showed that environmental size has a major impact on growth rate in surface fish, a trait we have termed space dependent growth (SDG). In contrast, SDG has regressed to different degrees in the Pachón and Tinaja populations of cavefish. Mating experiments between surface and Pachón cavefish show that SDG is inherited as a dominant trait and is controlled by multiple genetic factors. Despite its regression in blind cavefish, SDG is not affected when sighted surface fish are raised in darkness, indicating that vision is not required to perceive and react to environmental space. Analysis of plasma cortisol levels showed that an elevation above basal levels occurred soon after surface fish were exposed to confined space. This initial cortisol peak was absent in Pachón cavefish, suggesting that the effects of confined space on growth may be mediated partly through a stress response. We conclude that Astyanax reacts to confined spaces by exhibiting SDG, which has a genetic component and shows evolutionary regression during adaptation of cavefish to confined environments. PMID:22870223

Analyzing and synthesizing phylogenies using tree alignment graphs.

PubMed

Smith, Stephen A; Brown, Joseph W; Hinchliff, Cody E

2013-01-01

Phylogenetic trees are used to analyze and visualize evolution. However, trees can be imperfect datatypes when summarizing multiple trees. This is especially problematic when accommodating for biological phenomena such as horizontal gene transfer, incomplete lineage sorting, and hybridization, as well as topological conflict between datasets. Additionally, researchers may want to combine information from sets of trees that have partially overlapping taxon sets. To address the problem of analyzing sets of trees with conflicting relationships and partially overlapping taxon sets, we introduce methods for aligning, synthesizing and analyzing rooted phylogenetic trees within a graph, called a tree alignment graph (TAG). The TAG can be queried and analyzed to explore uncertainty and conflict. It can also be synthesized to construct trees, presenting an alternative to supertrees approaches. We demonstrate these methods with two empirical datasets. In order to explore uncertainty, we constructed a TAG of the bootstrap trees from the Angiosperm Tree of Life project. Analysis of the resulting graph demonstrates that areas of the dataset that are unresolved in majority-rule consensus tree analyses can be understood in more detail within the context of a graph structure, using measures incorporating node degree and adjacency support. As an exercise in synthesis (i.e., summarization of a TAG constructed from the alignment trees), we also construct a TAG consisting of the taxonomy and source trees from a recent comprehensive bird study. We synthesized this graph into a tree that can be reconstructed in a repeatable fashion and where the underlying source information can be updated. The methods presented here are tractable for large scale analyses and serve as a basis for an alternative to consensus tree and supertree methods. Furthermore, the exploration of these graphs can expose structures and patterns within the dataset that are otherwise difficult to observe.

Analyzing and Synthesizing Phylogenies Using Tree Alignment Graphs

PubMed Central

Smith, Stephen A.; Brown, Joseph W.; Hinchliff, Cody E.

2013-01-01

Phylogenetic trees are used to analyze and visualize evolution. However, trees can be imperfect datatypes when summarizing multiple trees. This is especially problematic when accommodating for biological phenomena such as horizontal gene transfer, incomplete lineage sorting, and hybridization, as well as topological conflict between datasets. Additionally, researchers may want to combine information from sets of trees that have partially overlapping taxon sets. To address the problem of analyzing sets of trees with conflicting relationships and partially overlapping taxon sets, we introduce methods for aligning, synthesizing and analyzing rooted phylogenetic trees within a graph, called a tree alignment graph (TAG). The TAG can be queried and analyzed to explore uncertainty and conflict. It can also be synthesized to construct trees, presenting an alternative to supertrees approaches. We demonstrate these methods with two empirical datasets. In order to explore uncertainty, we constructed a TAG of the bootstrap trees from the Angiosperm Tree of Life project. Analysis of the resulting graph demonstrates that areas of the dataset that are unresolved in majority-rule consensus tree analyses can be understood in more detail within the context of a graph structure, using measures incorporating node degree and adjacency support. As an exercise in synthesis (i.e., summarization of a TAG constructed from the alignment trees), we also construct a TAG consisting of the taxonomy and source trees from a recent comprehensive bird study. We synthesized this graph into a tree that can be reconstructed in a repeatable fashion and where the underlying source information can be updated. The methods presented here are tractable for large scale analyses and serve as a basis for an alternative to consensus tree and supertree methods. Furthermore, the exploration of these graphs can expose structures and patterns within the dataset that are otherwise difficult to observe. PMID:24086118

On the use of Bayesian Monte-Carlo in evaluation of nuclear data

NASA Astrophysics Data System (ADS)

De Saint Jean, Cyrille; Archier, Pascal; Privas, Edwin; Noguere, Gilles

2017-09-01

As model parameters, necessary ingredients of theoretical models, are not always predicted by theory, a formal mathematical framework associated to the evaluation work is needed to obtain the best set of parameters (resonance parameters, optical models, fission barrier, average width, multigroup cross sections) with Bayesian statistical inference by comparing theory to experiment. The formal rule related to this methodology is to estimate the posterior density probability function of a set of parameters by solving an equation of the following type: pdf(posterior) ˜ pdf(prior) × a likelihood function. A fitting procedure can be seen as an estimation of the posterior density probability of a set of parameters (referred as x→?) knowing a prior information on these parameters and a likelihood which gives the probability density function of observing a data set knowing x→?. To solve this problem, two major paths could be taken: add approximations and hypothesis and obtain an equation to be solved numerically (minimum of a cost function or Generalized least Square method, referred as GLS) or use Monte-Carlo sampling of all prior distributions and estimate the final posterior distribution. Monte Carlo methods are natural solution for Bayesian inference problems. They avoid approximations (existing in traditional adjustment procedure based on chi-square minimization) and propose alternative in the choice of probability density distribution for priors and likelihoods. This paper will propose the use of what we are calling Bayesian Monte Carlo (referred as BMC in the rest of the manuscript) in the whole energy range from thermal, resonance and continuum range for all nuclear reaction models at these energies. Algorithms will be presented based on Monte-Carlo sampling and Markov chain. The objectives of BMC are to propose a reference calculation for validating the GLS calculations and approximations, to test probability density distributions effects and to provide the framework of finding global minimum if several local minimums exist. Application to resolved resonance, unresolved resonance and continuum evaluation as well as multigroup cross section data assimilation will be presented.

Alternative Sources of Energy - An Introduction to Fuel Cells

USGS Publications Warehouse

Merewether, E.A.

2003-01-01

Fuel cells are important future sources of electrical power and could contribute to a reduction in the amount of petroleum imported by the United States. They are electrochemical devices similar to a battery and consist of a container, an anode, a cathode, catalysts, an intervening electrolyte, and an attached electrical circuit. In most fuel cell systems, hydrogen is supplied to the anode and oxygen to the cathode which results in the production of electricity, water, and heat. Fuel cells are comparatively efficient and reliable, have no moving parts, operate without combustion, and are modular and scale-able. Their size and shape are flexible and adaptable. In operation, they are nearly silent, are relatively safe, and generally do not pollute the environment. During recent years, scientists and engineers have developed and refined technologies relevant to a variety of fuel cells. Types of fuel cells are commonly identified by the composition of their electrolyte, which could be either phosphoric acid, an alkaline solution, a molten carbonate, a solid metal oxide, or a solid polymer membrane. The electrolyte in stationary power plants could be phosphoric acid, molten carbonates, or solid metal oxides. For vehicles and smaller devices, the electrolyte could be an alkaline solution or a solid polymer membrane. For most fuel cell systems, the fuel is hydrogen, which can be extracted by several procedures from many hydrogen-bearing substances, including alcohols, natural gas (mainly methane), gasoline, and water. There are important and perhaps unresolved technical problems associated with using fuel cells to power vehicles. The catalysts required in several systems are expensive metals of the platinum group. Moreover, fuel cells can freeze and not work in cold weather and can be damaged by impacts. Storage tanks for the fuels, particularly hydrogen, must be safe, inexpensive, of a reasonable size, and contain a supply sufficient for a trip of several hundred miles. Additional major problems will be the extensive and costly changes in the national infrastructure to obtain, store, and distribute large amounts of the fuels, and in related manufacturing

Optical interferometer in space

NASA Technical Reports Server (NTRS)

Bender, Peter L.; Faller, J. E.; Hall, J. L.; Hils, D.; Stebbins, R. T.; Vincent, Mark A.

1989-01-01

The present design concepts for a Laser Gravitational Wave Observatory in Space are described. Laser heterodyne distance measurements are made between test masses located in three spacecraft separated by roughly 10(exp 6) km. The major technology issues are: the reduction of spurious acceleration noise for the test masses to below 2 x 10(exp -15) cm/sq sec/Hz(0.5) from 10(exp -5) to 10(exp -3) Hz; and the measurement of changes in the difference of the antenna arm lengths to 5 x 10(exp -11) cm/Hz(0.5) from 10(exp -3) to 1 Hz with high reliability. The science objectives are: to measure discrete sinusoidal gravitational wave signals from individual sources with periods of 1 second to 1 day; to measure the stochastic background due to unresolved binaries; and to search for gravitational wave pulses with periods longer than 1 sec from possible exotic sources such as gravitational collapse of very massive objects.

Model documentation Natural Gas Transmission and Distribution Model of the National Energy Modeling System. Volume 1

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1996-02-26

The Natural Gas Transmission and Distribution Model (NGTDM) of the National Energy Modeling System is developed and maintained by the Energy Information Administration (EIA), Office of Integrated Analysis and Forecasting. This report documents the archived version of the NGTDM that was used to produce the natural gas forecasts presented in the Annual Energy Outlook 1996, (DOE/EIA-0383(96)). The purpose of this report is to provide a reference document for model analysts, users, and the public that defines the objectives of the model, describes its basic approach, and provides detail on the methodology employed. Previously this report represented Volume I of amore » two-volume set. Volume II reported on model performance, detailing convergence criteria and properties, results of sensitivity testing, comparison of model outputs with the literature and/or other model results, and major unresolved issues.« less

Extreme ecosystem instability suppressed tropical dinosaur dominance for 30 million years.

PubMed

Whiteside, Jessica H; Lindström, Sofie; Irmis, Randall B; Glasspool, Ian J; Schaller, Morgan F; Dunlavey, Maria; Nesbitt, Sterling J; Smith, Nathan D; Turner, Alan H

2015-06-30

A major unresolved aspect of the rise of dinosaurs is why early dinosaurs and their relatives were rare and species-poor at low paleolatitudes throughout the Late Triassic Period, a pattern persisting 30 million years after their origin and 10-15 million years after they became abundant and speciose at higher latitudes. New palynological, wildfire, organic carbon isotope, and atmospheric pCO2 data from early dinosaur-bearing strata of low paleolatitudes in western North America show that large, high-frequency, tightly correlated variations in δ(13)Corg and palynomorph ecotypes occurred within a context of elevated and increasing pCO2 and pervasive wildfires. Whereas pseudosuchian archosaur-dominated communities were able to persist in these same regions under rapidly fluctuating extreme climatic conditions until the end-Triassic, large-bodied, fast-growing tachymetabolic dinosaurian herbivores requiring greater resources were unable to adapt to unstable high CO2 environmental conditions of the Late Triassic.

Extreme ecosystem instability suppressed tropical dinosaur dominance for 30 million years

NASA Astrophysics Data System (ADS)

Whiteside, Jessica H.; Lindström, Sofie; Irmis, Randall B.; Glasspool, Ian J.; Schaller, Morgan F.; Dunlavey, Maria; Nesbitt, Sterling J.; Smith, Nathan D.; Turner, Alan H.

2015-06-01

A major unresolved aspect of the rise of dinosaurs is why early dinosaurs and their relatives were rare and species-poor at low paleolatitudes throughout the Late Triassic Period, a pattern persisting 30 million years after their origin and 10-15 million years after they became abundant and speciose at higher latitudes. New palynological, wildfire, organic carbon isotope, and atmospheric pCO2 data from early dinosaur-bearing strata of low paleolatitudes in western North America show that large, high-frequency, tightly correlated variations in δ13Corg and palynomorph ecotypes occurred within a context of elevated and increasing pCO2 and pervasive wildfires. Whereas pseudosuchian archosaur-dominated communities were able to persist in these same regions under rapidly fluctuating extreme climatic conditions until the end-Triassic, large-bodied, fast-growing tachymetabolic dinosaurian herbivores requiring greater resources were unable to adapt to unstable high CO2 environmental conditions of the Late Triassic.