Recent Progress in Light-Triggered Nanotheranostics for Cancer Treatment

PubMed Central

Zhang, Pengcheng; Hu, Chunhua; Ran, Wei; Meng, Jia; Yin, Qi; Li, Yaping

2016-01-01

Treatments of high specificity are desirable for cancer therapy. Light-triggered nanotheranostics (LTN) mediated cancer therapy could be one such treatment, as they make it possible to visualize and treat the tumor specifically in a light-controlled manner with a single injection. Because of their great potential in cancer therapy, many novel and powerful LTNs have been developed, and are mainly prepared from photosensitizers (PSs) ranging from small organic dyes such as porphyrin- and cyanine-based dyes, semiconducting polymers, to inorganic nanomaterials such as gold nanoparticles, transition metal chalcogenides, carbon nanotubes and graphene. Using LTNs and localized irradiation in combination, complete tumor ablation could be achieved in tumor-bearing animal models without causing significant toxicity. Given their great advances and promising future, we herein review LTNs that have been tested in vivo with a highlight on progress that has been made in the past a couple of years. The current challenges faced by these LTNs are also briefly discussed. PMID:27217830

Very high-energy gamma rays from gamma-ray bursts.

PubMed

Chadwick, Paula M

2007-05-15

Very high-energy (VHE) gamma-ray astronomy has undergone a transformation in the last few years, with telescopes of unprecedented sensitivity having greatly expanded the source catalogue. Such progress makes the detection of a gamma-ray burst at the highest energies much more likely than previously. This paper describes the facilities currently operating and their chances for detecting gamma-ray bursts, and reviews predictions for VHE gamma-ray emission from gamma-ray bursts. Results to date are summarized.

Advanced techniques for the storage and use of very large, heterogeneous spatial databases

NASA Technical Reports Server (NTRS)

Peuquet, Donna J.

1987-01-01

Progress is reported in the development of a prototype knowledge-based geographic information system. The overall purpose of this project is to investigate and demonstrate the use of advanced methods in order to greatly improve the capabilities of geographic information system technology in the handling of large, multi-source collections of spatial data in an efficient manner, and to make these collections of data more accessible and usable for the Earth scientist.

A spatial classification and database for management, research, and policy making: The Great Lakes aquatic habitat framework

USGS Publications Warehouse

Wang, Lizhu; Riseng, Catherine M.; Mason, Lacey; Werhrly, Kevin; Rutherford, Edward; McKenna, James E.; Castiglione, Chris; Johnson, Lucinda B.; Infante, Dana M.; Sowa, Scott P.; Robertson, Mike; Schaeffer, Jeff; Khoury, Mary; Gaiot, John; Hollenhurst, Tom; Brooks, Colin N.; Coscarelli, Mark

2015-01-01

Managing the world's largest and most complex freshwater ecosystem, the Laurentian Great Lakes, requires a spatially hierarchical basin-wide database of ecological and socioeconomic information that is comparable across the region. To meet such a need, we developed a spatial classification framework and database — Great Lakes Aquatic Habitat Framework (GLAHF). GLAHF consists of catchments, coastal terrestrial, coastal margin, nearshore, and offshore zones that encompass the entire Great Lakes Basin. The catchments captured in the database as river pour points or coastline segments are attributed with data known to influence physicochemical and biological characteristics of the lakes from the catchments. The coastal terrestrial zone consists of 30-m grid cells attributed with data from the terrestrial region that has direct connection with the lakes. The coastal margin and nearshore zones consist of 30-m grid cells attributed with data describing the coastline conditions, coastal human disturbances, and moderately to highly variable physicochemical and biological characteristics. The offshore zone consists of 1.8-km grid cells attributed with data that are spatially less variable compared with the other aquatic zones. These spatial classification zones and their associated data are nested within lake sub-basins and political boundaries and allow the synthesis of information from grid cells to classification zones, within and among political boundaries, lake sub-basins, Great Lakes, or within the entire Great Lakes Basin. This spatially structured database could help the development of basin-wide management plans, prioritize locations for funding and specific management actions, track protection and restoration progress, and conduct research for science-based decision making.

Learning to cooperate is essential for progress in physics

NASA Astrophysics Data System (ADS)

Dickau, Jonathan J.

2012-06-01

At the 10th Frontiers of Fundamental Physics symposium, Gerard't Hooft stated that, for some of the advances we hope to see in Physics during the future, there must be a great deal of cooperation between physicists from different disciplines, as well as mathematicians, programmers, technologists, and others. This requires us to evolve a new mindset; however, as so much of our past progress has come out of a fiercely competitive process - especially since a critical review of our ideas about reality remains essential to making clear progress and checking our progress. We must also address the fact that some frameworks appear incompatible, as with relativity and quantum mechanics, whose unification remains distant despite years of attempts to find a quantum gravity theory. I explore the idea that playful exploration, using both left-brained and right-brained approaches to learning, allows us to resolve conflicting ideas by taking advantage of innate human developmental and learning strategies and brain structure. It may thus foster the kind of interdisciplinary cooperation we are hoping to see.

Introduction

NASA Astrophysics Data System (ADS)

Bouma, Brett E.

1998-09-01

The pace of technological advancement of Optical Coherence Tomography (OCT) over the last several years has been extremely rapid. The field has progressed from one-dimensional low-coherence ranging to full three-dimensional imaging with individual two-dimensional images aquired at near video rate in a span of less than eight years. Imaging applications have included polymers and advanced composites, Ophthalmology, Developmental Biology, Gastroenterology, Urology, Cardiology, Neurology, and Gynecology. These preliminary studies indicate the great potential for OCT to make a significant impact, especially in clinical medicine.

Nutritionally enhanced food crops; progress and perspectives.

PubMed

Hefferon, Kathleen L

2015-02-11

Great progress has been made over the past decade with respect to the application of biotechnology to generate nutritionally improved food crops. Biofortified staple crops such as rice, maize and wheat harboring essential micronutrients to benefit the world's poor are under development as well as new varieties of crops which have the ability to combat chronic disease. This review discusses the improvement of the nutritional status of crops to make a positive impact on global human health. Several examples of nutritionally enhanced crops which have been developed using biotechnological approaches will be discussed. These range from biofortified crops to crops with novel abilities to fight disease. The review concludes with a discussion of hurdles faced with respect to public perception, as well as directions of future research and development for nutritionally enhanced food crops.

Improper ferroelectric polarization in a perovskite driven by intersite charge transfer and ordering

NASA Astrophysics Data System (ADS)

Chen, Wei-Tin; Wang, Chin-Wei; Wu, Hung-Cheng; Chou, Fang-Cheng; Yang, Hung-Duen; Simonov, Arkadiy; Senn, M. S.

2018-04-01

It is of great interest to design and make materials in which ferroelectric polarization is coupled to other order parameters such as lattice, magnetic, and electronic instabilities. Such materials will be invaluable in next-generation data storage devices. Recently, remarkable progress has been made in understanding improper ferroelectric coupling mechanisms that arise from lattice and magnetic instabilities. However, although theoretically predicted, a compact lattice coupling between electronic and ferroelectric (polar) instabilities has yet to be realized. Here we report detailed crystallographic studies of a perovskite HgAMn3A'Mn4BO12 that is found to exhibit a polar ground state on account of such couplings that arise from charge and orbital ordering on both the A'- and B-sites, which are themselves driven by a highly unusual MnA '-MnB intersite charge transfer. The inherent coupling of polar, charge, orbital, and hence magnetic degrees of freedom make this a system of great fundamental interest, and demonstrating ferroelectric switching in this and a host of recently reported hybrid improper ferroelectrics remains a substantial challenge.

Radioisotopes for research on and control of mosquitos

PubMed Central

Bruce-Chwatt, Leonard J.

1956-01-01

Practical applications of radioactive isotopes in medicine, science, and industry have multiplied enormously during the past five years. In this paper, the author attempts to gather what is known about the use of radioactive isotopes in the research on malaria control. The development of the uranium pile for large-scale production of radioisotopes and technical progress in the making of reliable electronic equipment have greatly contributed to the application of radioactive tracers in biological research. The present knowledge of radioisotopes in mosquito and in insecticide research is discussed. ImagesFIG. 1 PMID:13404435

Progress in utilization of a mobile laboratory for making storm electricity measurements

NASA Technical Reports Server (NTRS)

Rust, W. David

1988-01-01

A mobile atmospheric science laboratory has been used to intercept and track storms on the Great Plains region of the U.S., with the intention of combining the data obtained with those from Doppler and conventional radars, NASA U-2 aircraft overflights, balloon soundings, and fixed-base storm electricity measurements. The mobile lab has proven to be valuable in the gathering of ground truth verifications for the two commercially operated lightning ground-strike locating systems. Data acquisition has recently been expanded by means of mobile ballooning before and during storms.

Cadaveric organ donation in China: A crossroads for ethics and sociocultural factors.

PubMed

Wu, Yijin; Elliott, Robert; Li, Linzi; Yang, Tongwei; Bai, Yusen; Ma, Wen

2018-03-01

In this paper, we will discuss several ethical issues concerning cadaveric organ donation from the perspective of sociocultural factors that are unique to China under the condition that China has ended the use of executed prisoner's organs for transplants. It is found that though great developments have been made in organ transplantation, the ethical issues relating to organ transplantation still face dilemmas in China. It is argued that organ donation and transplantation in China could make further progress if the ethical issues proposed in this paper can be carefully considered.

Inflammation to cancer: The molecular biology in the pancreas (Review).

PubMed

Ling, Sunbin; Feng, Tingting; Jia, Kaiqi; Tian, Yu; Li, Yan

2014-06-01

Inflammatory responses are known to be correlated with cancer initiation and progression, and exploration of the route from inflammation to cancer makes a great contribution in elucidating the mechanisms underlying cancer development. Pancreatic cancer (PC) is a lethal disease with a low radical-resection rate and a poor prognosis. As chronic pancreatitis is considered to be a significant etiological factor for PC development, the current review aims to describe the molecular pathways from inflammation to pancreatic carcinogenesis, in support of the strategies for the prevention, diagnosis and treatment of PC.

Cadaveric organ donation in China

PubMed Central

Wu, Yijin; Elliott, Robert; Li, Linzi; Yang, Tongwei; Bai, Yusen; Ma, Wen

2018-01-01

Abstract In this paper, we will discuss several ethical issues concerning cadaveric organ donation from the perspective of sociocultural factors that are unique to China under the condition that China has ended the use of executed prisoner's organs for transplants. It is found that though great developments have been made in organ transplantation, the ethical issues relating to organ transplantation still face dilemmas in China. It is argued that organ donation and transplantation in China could make further progress if the ethical issues proposed in this paper can be carefully considered. PMID:29517702

[Progress in stem cells and regenerative medicine].

PubMed

Wang, Libin; Zhu, He; Hao, Jie; Zhou, Qi

2015-06-01

Stem cells have the ability to differentiate into all types of cells in the body and therefore have great application potential in regenerative medicine, in vitro disease modelling and drug screening. In recent years, stem cell technology has made great progress, and induced pluripotent stem cell technology revolutionizes the whole stem cell field. At the same time, stem cell research in our country has also achieved great progress and becomes an indispensable power in the worldwide stem cell research field. This review mainly focuses on the research progress in stem cells and regenerative medicine in our country since the advent of induced pluripotent stem cell technology, including induced pluripotent stem cells, transdifferentiation, haploid stem cells, and new gene editing tools.

The Next Great Ship: NASA's Space Launch System

NASA Technical Reports Server (NTRS)

May, Todd A.

2013-01-01

Topics covered include: Most Capable U.S. Launch Vehicle; Liquid engines Progress; Boosters Progress; Stages and Avionics Progress; Systems Engineering and Integration Progress; Spacecraft and Payload Integration Progress; Advanced Development Progress.

Nutritionally Enhanced Food Crops; Progress and Perspectives

PubMed Central

Hefferon, Kathleen L.

2015-01-01

Great progress has been made over the past decade with respect to the application of biotechnology to generate nutritionally improved food crops. Biofortified staple crops such as rice, maize and wheat harboring essential micronutrients to benefit the world’s poor are under development as well as new varieties of crops which have the ability to combat chronic disease. This review discusses the improvement of the nutritional status of crops to make a positive impact on global human health. Several examples of nutritionally enhanced crops which have been developed using biotechnological approaches will be discussed. These range from biofortified crops to crops with novel abilities to fight disease. The review concludes with a discussion of hurdles faced with respect to public perception, as well as directions of future research and development for nutritionally enhanced food crops. PMID:25679450

Progress in GaN devices performances and reliability

NASA Astrophysics Data System (ADS)

Saunier, P.; Lee, C.; Jimenez, J.; Balistreri, A.; Dumka, D.; Tserng, H. Q.; Kao, M. Y.; Chowdhury, U.; Chao, P. C.; Chu, K.; Souzis, A.; Eliashevich, I.; Guo, S.; del Alamo, J.; Joh, J.; Shur, M.

2008-02-01

With the DARPA Wide Bandgap Semiconductor Technology RF Thrust Contract, TriQuint Semiconductor and its partners, BAE Systems, Lockheed Martin, IQE-RF, II-VI, Nitronex, M.I.T., and R.P.I. are achieving great progress towards the overall goal of making Gallium Nitride a revolutionary RF technology ready to be inserted in defense and commercial applications. Performance and reliability are two critical components of success (along with cost and manufacturability). In this paper we will discuss these two aspects. Our emphasis is now operation at 40 V bias voltage (we had been working at 28 V). 1250 µm devices have power densities in the 6 to 9 W/mm with associated efficiencies in the low- to mid 60 % and associated gain in the 12 to 12.5 dB at 10 GHz. We are using a dual field-plate structure to optimize these performances. Very good performances have also been achieved at 18 GHz with 400 µm devices. Excellent progress has been made in reliability. Our preliminary DC and RF reliability tests at 40 V indicate a MTTF of 1E6hrs with1.3 eV activation energy at 150 0C channel temperature. Jesus Del Alamo at MIT has greatly refined our initial findings leading to a strain related theory of degradation that is driven by electric fields. Degradation can occur on the drain edge of the gate due to excessive strain given by inverse piezoelectric effect.

Neuroprotective "agents" in surgery. Secret "agent" man, or common "agent" machine?

NASA Technical Reports Server (NTRS)

Andrews, R. J.

1999-01-01

The search for clinically-effective neuroprotective agents has received enormous support in recent years--an estimated $200 million by pharmaceutical companies on clinical trials for traumatic brain injury alone. At the same time, the pathophysiology of brain injury has proved increasingly complex, rendering the likelihood of a single agent "magic bullet" even more remote. On the other hand, great progress continues with technology that makes surgery less invasive and less risky. One example is the application of endovascular techniques to treat coronary artery stenosis, where both the invasiveness of sternotomy and the significant neurological complication rate (due to microemboli showering the cerebral vasculature) can be eliminated. In this paper we review aspects of intraoperative neuroprotection both present and future. Explanations for the slow progress on pharmacologic neuroprotection during surgery are presented. Examples of technical advances that have had great impact on neuroprotection during surgery are given both from coronary artery stenosis surgery and from surgery for Parkinson's disease. To date, the progress in neuroprotection resulting from such technical advances is an order of magnitude greater than that resulting from pharmacologic agents used during surgery. The progress over the last 20 years in guidance during surgery (CT and MRI image-guidance) and in surgical access (endoscopic and endovascular techniques) will soon be complemented by advances in our ability to evaluate biological tissue intraoperatively in real-time. As an example of such technology, the NASA Smart Probe project is considered. In the long run (i.e., in 10 years or more), pharmacologic "agents" aimed at the complex pathophysiology of nervous system injury in man will be the key to true intraoperative neuroprotection. In the near term, however, it is more likely that mundane "agents" based on computers, microsensors, and microeffectors will be the major impetus to improved intraoperative neuroprotection.

Neural mechanisms associated with treatment decision making: An fMRI study.

PubMed

Abidi, Malek; Bruce, Jared; Le Blanche, Alain; Bruce, Amanda; Jarmolowicz, David P; Csillik, Antonia; Thai, N Jade; Lim, Seung-Lark; Heinzlef, Olivier; de Marco, Giovanni

2018-04-23

Great progress has been made in understanding how people make financial decisions. However, there is little research on how people make health and treatment choices. Our study aimed to examine how participants weigh benefits (reduction in disease progression) and probability of risk (medications' side effects) when making hypothetical treatment decisions, and to identify the neural networks implicated in this process. Fourteen healthy participants were recruited to perform a treatment decision probability discounting task using MRI. Behavioral responses and skin conductance responses (SCRs) were measured. A whole brain analysis were performed to compare activity changes between "mild" and "severe" medications' side effects conditions. Then, orbitofrontal cortex (OFC), ventral striatum (VS), amygdala and insula were chosen for effective connectivity analysis. Behavioral data showed that participants are more likely to refuse medication when side effects are high and efficacy is low. SCRs values were significantly higher when people made medication decisions in the severe compared to mild condition. Functionally, OFC and VS were activated in the mild condition and were associated with increased likehood of choosing to take medication (higher area under the curve "AUC" side effects/efficacy). These regions also demonstrated an increased effective connectivity when participants valued treatment benefits. By contrast, the OFC, insula and amygdala were activated in the severe condition and were associated with and increased likelihood to refuse treatment. These regions showed enhanced effective connectivity when participants were confronted with increased side effects severity. This is the first study to examine the behavioral and neural bases of medical decision making. Copyright © 2018 Elsevier B.V. All rights reserved.

Transmission Parameters of the 2001 Foot and Mouth Epidemic in Great Britain

PubMed Central

Chis Ster, Irina; Ferguson, Neil M.

2007-01-01

Despite intensive ongoing research, key aspects of the spatial-temporal evolution of the 2001 foot and mouth disease (FMD) epidemic in Great Britain (GB) remain unexplained. Here we develop a Markov Chain Monte Carlo (MCMC) method for estimating epidemiological parameters of the 2001 outbreak for a range of simple transmission models. We make the simplifying assumption that infectious farms were completely observed in 2001, equivalent to assuming that farms that were proactively culled but not diagnosed with FMD were not infectious, even if some were infected. We estimate how transmission parameters varied through time, highlighting the impact of the control measures on the progression of the epidemic. We demonstrate statistically significant evidence for assortative contact patterns between animals of the same species. Predictive risk maps of the transmission potential in different geographic areas of GB are presented for the fitted models. PMID:17551582

An Improved Binary Differential Evolution Algorithm to Infer Tumor Phylogenetic Trees.

PubMed

Liang, Ying; Liao, Bo; Zhu, Wen

2017-01-01

Tumourigenesis is a mutation accumulation process, which is likely to start with a mutated founder cell. The evolutionary nature of tumor development makes phylogenetic models suitable for inferring tumor evolution through genetic variation data. Copy number variation (CNV) is the major genetic marker of the genome with more genes, disease loci, and functional elements involved. Fluorescence in situ hybridization (FISH) accurately measures multiple gene copy number of hundreds of single cells. We propose an improved binary differential evolution algorithm, BDEP, to infer tumor phylogenetic tree based on FISH platform. The topology analysis of tumor progression tree shows that the pathway of tumor subcell expansion varies greatly during different stages of tumor formation. And the classification experiment shows that tree-based features are better than data-based features in distinguishing tumor. The constructed phylogenetic trees have great performance in characterizing tumor development process, which outperforms other similar algorithms.

Extraterrestrial Life as the Great Analogy, Two Centuries Ago and in Modern Astrobiology

NASA Astrophysics Data System (ADS)

Sullivan, Woodruff T.

Mainstream ideas on the existence of extraterrestrial life in the late 18th and early 19th centuries are examined, with a focus on William Herschel, one of the greatest astronomers of all time. Herschel viewed all of the planets and moons of our solar system as inhabited, and gave logical arguments that even the Sun, and by extension all of the stars, was a giant planet fit for habitation by intelligent beings. The importance for astrobiology both two centuries ago and now of the type of inductive reasoning called "analogy" is emphasized. Analogy is an imperfect tool, but given that we have only one known case of life and of a life-bearing planet, it is very difficult to make progress in astrobiology without resorting to analogy, in particular between known life and possible other life. We cannot overcome the "N = 1 Problem" without resorting to this "Great Analogy" to guide our research.

Current progress in 3D printing for cardiovascular tissue engineering.

PubMed

Mosadegh, Bobak; Xiong, Guanglei; Dunham, Simon; Min, James K

2015-03-16

3D printing is a technology that allows the fabrication of structures with arbitrary geometries and heterogeneous material properties. The application of this technology to biological structures that match the complexity of native tissue is of great interest to researchers. This mini-review highlights the current progress of 3D printing for fabricating artificial tissues of the cardiovascular system, specifically the myocardium, heart valves, and coronary arteries. In addition, how 3D printed sensors and actuators can play a role in tissue engineering is discussed. To date, all the work with building 3D cardiac tissues have been proof-of-principle demonstrations, and in most cases, yielded products less effective than other traditional tissue engineering strategies. However, this technology is in its infancy and therefore there is much promise that through collaboration between biologists, engineers and material scientists, 3D bioprinting can make a significant impact on the field of cardiovascular tissue engineering.

Research progress on the brewing techniques of new-type rice wine.

PubMed

Jiao, Aiquan; Xu, Xueming; Jin, Zhengyu

2017-01-15

As a traditional alcoholic beverage, Chinese rice wine (CRW) with high nutritional value and unique flavor has been popular in China for thousands of years. Although traditional production methods had been used without change for centuries, numerous technological innovations in the last decades have greatly impacted on the CRW industry. However, reviews related to the technology research progress in this field are relatively few. This article aimed at providing a brief summary of the recent developments in the new brewing technologies for making CRW. Based on the comparison between the conventional methods and the innovative technologies of CRW brewing, three principal aspects were summarized and sorted, including the innovation of raw material pretreatment, the optimization of fermentation and the reform of sterilization technology. Furthermore, by comparing the advantages and disadvantages of these methods, various issues are addressed related to the prospect of the CRW industry. Copyright © 2016 Elsevier Ltd. All rights reserved.

Stem cell research in pakistan; past, present and future.

PubMed

Zahra, Sayeda Anum; Muzavir, Sayed Raheel; Ashraf, Sadia; Ahmad, Aftab

2015-05-01

Stem cells have proved to have great therapeutic potential as stem cell treatment is replacing traditional ways of treatment in different disorders like cancer, aplastic anemia, stroke, heart disorders. The developed and developing countries are investing differently in this area of research so research output and clinical translation of research greatly vary among developed and developing countries. Present study was done to investigate the current status of stem cells research in Pakistan and ways to improve it. Many advanced countries (USA, UK and Canada etc.) are investing heavily in stem cell research and treatment. Different developing countries like Iran, Turkey and India are also following the developed countries and investing a lot in stem cells research. Pakistan is also making efforts in establishing this field to get desired benefits but unfortunately the progress is at very low pace. If Government plays an active role along with private sector, stem cell research in Pakistan can be boosted up. The numbers of publications from Pakistan are very less compared to developed and neighboring countries and Pakistan also has very less number of institutes working in this area of research. Stem cells research is at its initial stages in Pakistan and there is great need to bring Government, academia and industry together so they could make serious efforts to promote research in this very important field. This will help millions of patients suffering from incurable disorders and will also reduce economic loss.

TACIT: An open-source text analysis, crawling, and interpretation tool.

PubMed

Dehghani, Morteza; Johnson, Kate M; Garten, Justin; Boghrati, Reihane; Hoover, Joe; Balasubramanian, Vijayan; Singh, Anurag; Shankar, Yuvarani; Pulickal, Linda; Rajkumar, Aswin; Parmar, Niki Jitendra

2017-04-01

As human activity and interaction increasingly take place online, the digital residues of these activities provide a valuable window into a range of psychological and social processes. A great deal of progress has been made toward utilizing these opportunities; however, the complexity of managing and analyzing the quantities of data currently available has limited both the types of analysis used and the number of researchers able to make use of these data. Although fields such as computer science have developed a range of techniques and methods for handling these difficulties, making use of those tools has often required specialized knowledge and programming experience. The Text Analysis, Crawling, and Interpretation Tool (TACIT) is designed to bridge this gap by providing an intuitive tool and interface for making use of state-of-the-art methods in text analysis and large-scale data management. Furthermore, TACIT is implemented as an open, extensible, plugin-driven architecture, which will allow other researchers to extend and expand these capabilities as new methods become available.

Multi-alternative decision-making with non-stationary inputs.

PubMed

Nunes, Luana F; Gurney, Kevin

2016-08-01

One of the most widely implemented models for multi-alternative decision-making is the multihypothesis sequential probability ratio test (MSPRT). It is asymptotically optimal, straightforward to implement, and has found application in modelling biological decision-making. However, the MSPRT is limited in application to discrete ('trial-based'), non-time-varying scenarios. By contrast, real world situations will be continuous and entail stimulus non-stationarity. In these circumstances, decision-making mechanisms (like the MSPRT) which work by accumulating evidence, must be able to discard outdated evidence which becomes progressively irrelevant. To address this issue, we introduce a new decision mechanism by augmenting the MSPRT with a rectangular integration window and a transparent decision boundary. This allows selection and de-selection of options as their evidence changes dynamically. Performance was enhanced by adapting the window size to problem difficulty. Further, we present an alternative windowing method which exponentially decays evidence and does not significantly degrade performance, while greatly reducing the memory resources necessary. The methods presented have proven successful at allowing for the MSPRT algorithm to function in a non-stationary environment.

Recent advances of microbial breeding via heavy-ion mutagenesis at IMP.

PubMed

Hu, W; Li, W; Chen, J

2017-10-01

Nowadays, the value of heavy-ion mutagenesis has been accepted as a novel powerful mutagen technique to generate new microbial mutants due to its high linear energy transfer and high relative biological effectiveness. This paper briefly reviews recent progress in developing a more efficient mutagenesis technique for microbial breeding using heavy-ion mutagenesis, and also presents the outline of the beam line for microbial breeding in Heavy Ion Research Facility of Lanzhou. Then, new insights into microbial biotechnology via heavy-ion mutagenesis are also further explored. We hope that our concerns will give deep insight into microbial breeding biotechnology via heavy-ion mutagenesis. We also believe that heavy-ion mutagenesis breeding will greatly contribute to the progress of a comprehensive study industrial strain engineering for bioindustry in the future. There is currently a great interest in developing rapid and diverse microbial mutation tool for strain modification. Heavy-ion mutagenesis has been proved as a powerful technology for microbial breeding due to its broad spectrum of mutation phenotypes with high efficiency. In order to deeply understand heavy-ion mutagenesis technology, this paper briefly reviews recent progress in microbial breeding using heavy-ion mutagenesis at IMP, and also presents the outline of the beam line for microbial breeding in Heavy Ion Research Facility of Lanzhou (HIRFL) as well as new insights into microbial biotechnology via heavy-ion mutagenesis. Thus, this work can provide the guidelines to promote the development of novel microbial biotechnology cross-linking heavy-ion mutagenesis breeding that could make breeding process more efficiently in the future. © 2017 The Society for Applied Microbiology.

Genetic responses to rapid change in the environment during the anthropocene

USGS Publications Warehouse

Tallmon, David A.; Kovach, Ryan

2017-01-01

Humans have greatly affected the genetic composition of many different organisms during the Anthropocene. Humans cause genetic changes by affecting the direction and magnitude of evolutionary forces that act to create the Earth's biota. In many cases, we expect the outcome of human actions to be extinction and hybridization of existing species, but other outcomes, such as adaptation, also occur. Given the reach of humans throughout the globe, and recent biotechnology advances that make it possible to move individual genes between species or to remove them, it is likely that human influence on the genetic composition of other organisms will become even more widespread as the Anthropocene progresses.

The liquid droplet radiator: Status of development

NASA Astrophysics Data System (ADS)

Persson, J.

1991-12-01

The ever greater amounts of power to be dissipated onboard future spacecraft, together with their limited external dimensions, will make it increasingly difficult to use conventional radiator technology without imposing a severe mass penalty. Hunting for lightweight alternatives to current heat rejection systems has become a matter of growing urgency, which explains the great interest that the Liquid Droplet Radiator (LDR) has attracted. Tradeoff analyses indicate that an LDR may be as much as an order of magnitude lighter than a comparable conventional radiator. A literature study examining the progress of the LDR research and some of its possible applications is reviewed. An investigation of the LDR heat rejection capability is presented.

Wavelet-enabled progressive data Access and Storage Protocol (WASP)

NASA Astrophysics Data System (ADS)

Clyne, J.; Frank, L.; Lesperance, T.; Norton, A.

2015-12-01

Current practices for storing numerical simulation outputs hail from an era when the disparity between compute and I/O performance was not as great as it is today. The memory contents for every sample, computed at every grid point location, are simply saved at some prescribed temporal frequency. Though straightforward, this approach fails to take advantage of the coherency in neighboring grid points that invariably exists in numerical solutions to mathematical models. Exploiting such coherence is essential to digital multimedia; DVD-Video, digital cameras, streaming movies and audio are all possible today because of transform-based compression schemes that make substantial reductions in data possible by taking advantage of the strong correlation between adjacent samples in both space and time. Such methods can also be exploited to enable progressive data refinement in a manner akin to that used in ubiquitous digital mapping applications: views from far away are shown in coarsened detail to provide context, and can be progressively refined as the user zooms in on a localized region of interest. The NSF funded WASP project aims to provide a common, NetCDF-compatible software framework for supporting wavelet-based, multi-scale, progressive data, enabling interactive exploration of large data sets for the geoscience communities. This presentation will provide an overview of this work in progress to develop community cyber-infrastructure for the efficient analysis of very large data sets.

Grounding Zone and Tidal Response of the Amery Ice Shelf, East Antarctica

NASA Technical Reports Server (NTRS)

Fricker, Helen A.; Sandwell, David; Coleman, Richard; Minster, Bernard

2005-01-01

This report summarizes the main findings of the research project. Unfortunately, it turned out that there was not a great deal of SAR data over the Amery Ice Shelf that we were able to work with on the project; nevertheless, we did make considerable progress on this project, with both the existing SAR data and new field measurements that were collected under this grant. In total we had constructed two SAR interferograms (SSIs), and four SSIs. The latter were combined them to construct two differential SAR interferograms (DSIs;). DSIs are useful because the contribution to the SAR phase from horizontal ice motion is eliminated, since the time difference between the first and second pass within both image pairs used to make the DSI is the same for each pair. The SSIs and DSIs have revealed several interesting glaciological features, and have added to our knowledge of the Amery Ice Shelf (AIS).

Towards Actionable Waterborne and Vector-borne Disease Forecasts

NASA Astrophysics Data System (ADS)

Zaitchik, B. F.

2015-12-01

Numerous studies have shown that remote sensing (RS) and Earth System Models (ESM) can make important contributions to the analysis, monitoring and prediction of waterborne and vector-borne illnesses. Unsurprisingly, however, the great majority of these studies have been proof-of-concept investigations, and vanishingly few have been translated into operational and utilized disease early warning systems. To some extent this is simply an example of the general challenge of translating research findings into decision-relevant operations. Disease early warning, however, entails specific challenges that distinguish it from many other fields of environmental monitoring and prediction. Some of these challenges stem from predictability and data constraints, while others relate to the difficulty of communicating predictions and the particularly high price of false alarms. This presentation will review progress on the translation of analysis to decision making, identify avenues for enhancing forecast utility, and propose priorities for future RS and ESM investments in disease monitoring and prediction.

Progress in understanding the importance of coastal wetland nursery habitat to Great Lakes fisheries support

EPA Science Inventory

Great Lakes coastal wetlands provide important habitat for Great Lakes fishes of all life stages. A literature review of ichthyoplankton surveys conducted in Great Lakes coastal wetlands found at least 82 species reported to be captured during the larval stage. Twenty of those sp...

Who's afraid of Homo sapiens?

PubMed

Preuss, Todd M

2006-11-29

Understanding how humans differ from other animals, as well as how we are like them, requires comparative investigations. For the purpose of documenting the distinctive features of humans, the most informative research involves comparing humans to our closest relatives-the chimpanzees and other great apes. Psychology and anthropology have maintained a tradition of empirical comparative research on human specializations of cognition. The neurosciences, by contrast, have been dominated by the model-animal research paradigm, which presupposes the commonality of "basic" features of brain organization across species and discourages serious treatment of species differences. As a result, the neurosciences have made little progress in understanding human brain specializations. Recent developments in neuroimaging, genomics, and other non-invasive techniques make it possible to directly compare humans and nonhuman species at levels of organization that were previously inaccessible, offering the hope of gaining a better understanding of the species-specific features of the human brain. This hope will be dashed, however, if chimpanzees and other great ape species become unavailable for even non-invasive research.

Some New/Old Approaches to QCD

DOE R&D Accomplishments Database

Gross, D. J.

1992-11-01

In this lecture I shall discuss some recent attempts to revive some old ideas to address the problem of solving QCD. I believe that it is timely to return to this problem which has been woefully neglected for the last decade. QCD is a permanent part of the theoretical landscape and eventually we will have to develop analytic tools for dealing with the theory in the infra-red. Lattice techniques are useful but they have not yet lived up to their promise. Even if one manages to derive the hadronic spectrum numerically, to an accuracy of 10% or even 1%, we will not be truly satisfied unless we have some analytic understanding of the results. Also, lattice Monte-Carlo methods can only be used to answer a small set of questions. Many issues of great conceptual and practical interest-in particular the calculation of scattering amplitudes, are thus far beyond lattice control. Any progress in controlling QCD in an explicit analytic, fashion would be of great conceptual value. It would also be of great practical aid to experimentalists, who must use rather ad-hoc and primitive models of QCD scattering amplitudes to estimate the backgrounds to interesting new physics. I will discuss an attempt to derive a string representation of QCD and a revival of the large N approach to QCD. Both of these ideas have a long history, many theorist-years have been devoted to their pursuit-so far with little success. I believe that it is time to try again. In part this is because of the progress in the last few years in string theory. Our increased understanding of string theory should make the attempt to discover a stringy representation of QCD easier, and the methods explored in matrix models might be employed to study the large N limit of QCD.

Improvements in continuum modeling for biomolecular systems

NASA Astrophysics Data System (ADS)

Yu, Qiao; Ben-Zhuo, Lu

2016-01-01

Modeling of biomolecular systems plays an essential role in understanding biological processes, such as ionic flow across channels, protein modification or interaction, and cell signaling. The continuum model described by the Poisson- Boltzmann (PB)/Poisson-Nernst-Planck (PNP) equations has made great contributions towards simulation of these processes. However, the model has shortcomings in its commonly used form and cannot capture (or cannot accurately capture) some important physical properties of the biological systems. Considerable efforts have been made to improve the continuum model to account for discrete particle interactions and to make progress in numerical methods to provide accurate and efficient simulations. This review will summarize recent main improvements in continuum modeling for biomolecular systems, with focus on the size-modified models, the coupling of the classical density functional theory and the PNP equations, the coupling of polar and nonpolar interactions, and numerical progress. Project supported by the National Natural Science Foundation of China (Grant No. 91230106) and the Chinese Academy of Sciences Program for Cross & Cooperative Team of the Science & Technology Innovation.

Meshing of a Spiral Bevel Gearset with 3D Finite Element Analysis

NASA Technical Reports Server (NTRS)

Bibel, George D.; Handschuh, Robert

1996-01-01

Recent advances in spiral bevel gear geometry and finite element technology make it practical to conduct a structural analysis and analytically roll the gearset through mesh. With the advent of user specific programming linked to 3D solid modelers and mesh generators, model generation has become greatly automated. Contact algorithms available in general purpose finite element codes eliminate the need for the use and alignment of gap elements. Once the gearset is placed in mesh, user subroutines attached to the FE code easily roll the gearset through mesh. The method is described in detail. Preliminary results for a gearset segment showing the progression of the contact lineload is given as the gears roll through mesh.

Analysis and design of energy monitoring platform for smart city

NASA Astrophysics Data System (ADS)

Wang, Hong-xia

2016-09-01

The development and utilization of energy has greatly promoted the development and progress of human society. It is the basic material foundation for human survival. City running is bound to consume energy inevitably, but it also brings a lot of waste discharge. In order to speed up the process of smart city, improve the efficiency of energy saving and emission reduction work, maintain the green and livable environment, a comprehensive management platform of energy monitoring for government departments is constructed based on cloud computing technology and 3-tier architecture in this paper. It is assumed that the system will provide scientific guidance for the environment management and decision making in smart city.

Review of the magnetic fusion program by the 1986 ERAB Fusion Panel

NASA Astrophysics Data System (ADS)

Davidson, Ronald C.

1987-09-01

The 1986 ERAB Fusion Panel finds that fusion energy continues to be an attractive energy source with great potential for the future, and that the magnetic fusion program continues to make substantial technical progress. In addition, fusion research advances plasma physics, a sophisticated and useful branch of applied science, as well as technologies important to industry and defense. These factors fully justify the substantial expenditures by the Department of Energy in fusion research and development (R&D). The Panel endorses the overall program direction, strategy, and plans, and recognizes the importance and timeliness of proceeding with a burning plasma experiment, such as the proposed Compact Ignition Tokamak (CIT) experiment.

Progress and prospects of GaN-based VCSEL from near UV to green emission

NASA Astrophysics Data System (ADS)

Yu, Hsin-chieh; Zheng, Zhi-wei; Mei, Yang; Xu, Rong-bin; Liu, Jian-ping; Yang, Hui; Zhang, Bao-ping; Lu, Tien-chang; Kuo, Hao-chung

2018-01-01

GaN is a great material for making optoelectronic devices in the blue, blue-violet and green bands. Vertical-cavity surface-emitting lasers (VCSELs) have many advantages including small footprint, circular symmetry of output beam, two-dimensional scalability and/or addressability, surface-mount packaging, good price-performance ratio, and simple optics/alignment for output coupling. In this paper, we would like to (1) Review the design and fabrication of GaN-based VCSELs including some technology challenges, (2) Discuss the design and metalorganic chemical vapor deposition (MOCVD) growth of electrically pumped blue VCSELs and (3) Demonstrate world first green VCSEL using quantum dots (QDs) active region to overcome the 'green gap'.

Practice-based learning and improvement: a dream that can become a reality.

PubMed

Manning, Phil R

2003-01-01

Systematically enhancing learning from experience (practice-based learning) dominates the teachings of Sir William Osler and adult learning theorists such as Eduard Lindeman, Malcolm Knowles, and Cyril Houle. Because of time constraints, most physicians have not implemented methods that systematically facilitate learning from day-to-day work, but improvements in information technology offer the promise of making systematic practice-based learning practical. At least four ingredients need to be incorporated to significantly enhance learning from experience: a database that makes it possible to study individual practices; methods for supplying short, quick answers to questions while seeing patients; a reminder system to avoid errors of omission; and the opportunity to discuss practice data with colleagues. Great progress has been made, but significant barriers still must be overcome before a majority of physicians will participate. In particular, methods of data collection must be simplified, the delivery of point-of-care information and reminders must become more automatic, and physicians must develop skills to make the discussion of practice data acceptable, stimulating, and not unduly punitive.

The Progress of Research Project for Magnetized Target Fusion in China

NASA Astrophysics Data System (ADS)

Yang, Xian-Jun

2015-11-01

The fusion of magnetized plasma called Magnetized Target Fusion (MTF) is a hot research area recently. It may significantly reduce the cost and size. Great progress has been achieved in past decades around the world. Five years ago, China initiated the MTF project and has gotten some progress as follows: 1. Verifying the feasibility of ignition of MTF by means of first principle and MHD simulation; 2. Generating the magnetic field over 1400 Tesla, which can be suppress the heat conduction from charged particles, deposit the energy of alpha particle to promote the ignition process, and produce the stable magnetized plasma for the target of ignition; 3. The imploding facility of FP-1 can put several Mega Joule energy to the solid liner of about ten gram in the range of microsecond risen time, while the simulating tool has been developed for design and analysis of the process; 4. The target of FRC can be generated by ``YG 1 facility'' while some simulating tools have be developed. Next five years, the above theoretical work and the experiments of MTF may be integrated to step up as the National project, which may make my term play an important lead role and be supposed to achieve farther progress in China. Supported by the National Natural Science Foundation of China under Grant No 11175028.

Constructing Histories on Television: Reading the Country.

ERIC Educational Resources Information Center

Craik, Jennifer

The current tension in the writing of histories has been between the defense of "textbook" histories--i.e., the conventional approach which focuses on great events, great individuals, and great collectivities--and progressive--i.e., populist or alternative histories which focus on ordinary people. A new form has been engineered by…

Seasonal weather-related decision making for cattle production in the Northern Great Plains

USDA-ARS?s Scientific Manuscript database

High inter-annual variability of seasonal weather patterns can greatly affect forage and therefore livestock production in the Northern Great Plains. This variability can make it difficult for ranchers to set yearly stocking rates, particularly in advance of the grazing season. To better understand ...

A Bayesian Framework of Uncertainties Integration in 3D Geological Model

NASA Astrophysics Data System (ADS)

Liang, D.; Liu, X.

2017-12-01

3D geological model can describe complicated geological phenomena in an intuitive way while its application may be limited by uncertain factors. Great progress has been made over the years, lots of studies decompose the uncertainties of geological model to analyze separately, while ignored the comprehensive impacts of multi-source uncertainties. Great progress has been made over the years, while lots of studies ignored the comprehensive impacts of multi-source uncertainties when analyzed them item by item from each source. To evaluate the synthetical uncertainty, we choose probability distribution to quantify uncertainty, and propose a bayesian framework of uncertainties integration. With this framework, we integrated data errors, spatial randomness, and cognitive information into posterior distribution to evaluate synthetical uncertainty of geological model. Uncertainties propagate and cumulate in modeling process, the gradual integration of multi-source uncertainty is a kind of simulation of the uncertainty propagation. Bayesian inference accomplishes uncertainty updating in modeling process. Maximum entropy principle makes a good effect on estimating prior probability distribution, which ensures the prior probability distribution subjecting to constraints supplied by the given information with minimum prejudice. In the end, we obtained a posterior distribution to evaluate synthetical uncertainty of geological model. This posterior distribution represents the synthetical impact of all the uncertain factors on the spatial structure of geological model. The framework provides a solution to evaluate synthetical impact on geological model of multi-source uncertainties and a thought to study uncertainty propagation mechanism in geological modeling.

A National Crop Progress Monitoring and Decision Support System Based on NASA Earth Science Results

NASA Astrophysics Data System (ADS)

di, L.; Yang, Z.

2009-12-01

Timely and accurate information on weekly crop progress and development is essential to a dynamic agricultural industry in the U. S. and the world. By law, the National Agricultural Statistics Service (NASS) of the U. S. Department of Agriculture’s (USDA) is responsible for monitoring and assessing U.S. agricultural production. Currently NASS compiles and issues weekly state and national crop progress and development reports based on reports from knowledgeable state and county agricultural officials and farmers. Such survey-based reports are subjectively estimated for an entire county, lack spatial coverage, and are labor intensive. There has been limited use of remote sensing data to assess crop conditions. NASS produces weekly 1-km resolution un-calibrated AVHRR-based NDVI static images to represent national vegetation conditions but there is no quantitative crop progress information. This presentation discusses the early result for developing a National Crop Progress Monitoring and Decision Support System. The system will overcome the shortcomings of the existing systems by integrating NASA satellite and model-based land surface and weather products, NASS’ wealth of internal crop progress and condition data and Cropland Data Layers (CDL), and the Farm Service Agency’s (FSA) Common Land Units (CLU). The system, using service-oriented architecture and web service technologies, will automatically produce and disseminate quantitative national crop progress maps and associated decision support data at 250-m resolution, as well as summary reports to support NASS and worldwide users in their decision-making. It will provide overall and specific crop progress for individual crops from the state level down to CLU field level to meet different users’ needs on all known croplands. This will greatly enhance the effectiveness and accuracy of the NASS aggregated crop condition data and charts of and provides objective and scientific evidence and guidance for the adjustment of NASS survey data. This presentation will discuss the architecture, Earth observation data, and the crop progress model used in the decision support system.

Vanadium Dioxide Nanoparticle-based Thermochromic Smart Coating: High Luminous Transmittance, Excellent Solar Regulation Efficiency, and Near Room Temperature Phase Transition.

PubMed

Zhu, Jingting; Zhou, Yijie; Wang, Bingbing; Zheng, Jianyun; Ji, Shidong; Yao, Heliang; Luo, Hongjie; Jin, Ping

2015-12-23

An annealing-assisted preparation method of well-crystallized VxW1-xO2(M)@SiO2 core-shell nanoparticles for VO2-based thermochromic smart coatings (VTSC) is presented. The additional annealing process reduces the defect density of the initial hydrothermally prepared VxW1-xO2(M) nanoparticles and enhances their crystallinity so that the thermochromic film based on VxW1-xO2(M)@SiO2 nanoparticles can exhibit outstanding thermochromic performance with balanced solar regulation efficiency (ΔTsol) of 17.3%, luminous transmittance (Tlum) up to 52.2%, and critical phase transition temperature (Tc) around 40.4 °C, which is very promising for practical application. Furthermore, it makes great progress in reducing Tc of VTSC to near room temperature (25.2 °C) and simutaneously maintaining excellent optical properties (ΔTsol = 14.7% and Tlum = 50.6%). Such thermochromic performance is good enough to make VTSC applicable to practical architecture.

Accelerating global access to plant diversity information.

PubMed

Lughadha, Eimear Nic; Miller, Chuck

2009-11-01

Botanic gardens play key roles in the development and dissemination of plant information resources. Drivers for change have included progress in information technology, growing public expectations of electronic access and international conservation policy. Great advances have been made in the quantity, quality and accessibility of plant information in digital form and the extent to which information from multiple providers can be accessed through a single portal. However, significant challenges remain to be addressed in making botanic gardens resources maximally accessible and impactful, not least the overwhelming volume of material which still awaits digitisation. The year 2010 represents an opportunity for botanic gardens to showcase their collaborative achievements in delivery of electronic plant information and reinforce their relevance to pressing environmental issues.

microRNAs as cancer therapeutics: A step closer to clinical application.

PubMed

Catela Ivkovic, Tina; Voss, Gjendine; Cornella, Helena; Ceder, Yvonne

2017-10-28

During the last decades, basic and translational research has enabled great improvements in the clinical management of cancer. However, scarcity of complete remission and many drug-induced toxicities are still a major problem in the clinics. Recently, microRNAs (miRNAs) have emerged as promising therapeutic targets due to their involvement in cancer development and progression. Their extraordinary regulatory potential, which enables regulation of entire signalling networks within the cells, makes them an interesting tool for the development of cancer therapeutics. In this review we will focus on miRNAs with experimentally proven therapeutic potential, and discuss recent advances in the technical development and clinical evaluation of miRNA-based therapeutic agents. Copyright © 2017 Elsevier B.V. All rights reserved.

Research of ad hoc network based on SINCGARS network

NASA Astrophysics Data System (ADS)

Nie, Hao; Cai, Xiaoxia; Chen, Hong; Chen, Jian; Weng, Pengfei

2016-03-01

In today's world, science and technology make a spurt of progress, so society has entered the era of information technology, network. Only the comprehensive use of electronic warfare and network warfare means can we maximize their access to information and maintain the information superiority. Combined with the specific combat mission and operational requirements, the research design and construction in accordance with the actual military which are Suitable for the future of information technology needs of the tactical Adhoc network, tactical internet, will greatly improve the operational efficiency of the command of the army. Through the study of the network of the U.S. military SINCGARS network, it can explore the routing protocol and mobile model, to provide a reference for the research of our army network.

Systemic lupus erythematosus with initial presentation of empyematous pleural effusion in an elderly male patient: a diagnostic challenge.

PubMed

Chang, Wei-Ting; Hsieh, Tung-Han; Liu, Ming-Fei

2013-04-01

Systemic lupus erythematosus (SLE) poses great difficulty in making an early diagnosis in elderly males, often presenting with atypical manifestations. Acute onset of empyematous pleural effusion has rarely been seen. Herein, we report a 66-year-old man with SLE presenting with rapid progression of bilateral pleural effusion. Diagnostic thoracocentesis disclosed neutrophil-predominant exudates and chest computed tomography revealed multiple loculated pleural effusions. Nevertheless, optimal antibiotic therapy plus surgical decortication of the pleura did not improve his condition. The diagnosis of SLE was readily established after LE cells were accidentally found in the pleural effusion. Large amounts of pleural effusion subsided soon after high dose corticosteroid therapy. Copyright © 2011. Published by Elsevier B.V.

The future of dentistry: new challenges, new directions.

PubMed Central

Sinkford, J. C.

1990-01-01

The challenge to our profession today is to improve the quality of oral health while overcoming both extrinsic and intrinsic factors which may adversely affect our progress toward this goal. The combined efforts of dental education, dental research, and dental practice will be needed to enable us to maintain the quality of our present system and to meet the myriad changes that will chart our new directions in the future. Our unified efforts can make a difference and, thereby, ensure a meaningful and productive future for dentistry in our country and throughout the world. Let us show the world that the future of dentistry matters to us and that we look to the future with great anticipation and optimism. PMID:2352286

Power efficient optical communications for space applications

NASA Technical Reports Server (NTRS)

Lesh, J. R.

1982-01-01

Optical communications technology promises substantial size, weight and power consumption savings for space to space high data rate communications over presently used microwave technology. These benefits are further increased by making the most efficient use of the available optical signal energy. This presentation will describe the progress to date on a project to design, build and demonstrate in the laboratory an optical communication system capable of conveying 2.5 bits of information per effective received photon. Such high power efficiencies will reduce the need for photon collection at the receiver and will greatly reduce the requirements for optical pointing accuracy, both at the transmitter as well as the receiver. A longer range program to demonstrate even higher photon efficiencies will also be described.

Parallel Programming Strategies for Irregular Adaptive Applications

NASA Technical Reports Server (NTRS)

Biswas, Rupak; Biegel, Bryan (Technical Monitor)

2001-01-01

Achieving scalable performance for dynamic irregular applications is eminently challenging. Traditional message-passing approaches have been making steady progress towards this goal; however, they suffer from complex implementation requirements. The use of a global address space greatly simplifies the programming task, but can degrade the performance for such computations. In this work, we examine two typical irregular adaptive applications, Dynamic Remeshing and N-Body, under competing programming methodologies and across various parallel architectures. The Dynamic Remeshing application simulates flow over an airfoil, and refines localized regions of the underlying unstructured mesh. The N-Body experiment models two neighboring Plummer galaxies that are about to undergo a merger. Both problems demonstrate dramatic changes in processor workloads and interprocessor communication with time; thus, dynamic load balancing is a required component.

Neuroscience and education.

PubMed

Goswami, Usha

2004-03-01

Neuroscience is a relatively new discipline encompassing neurology, psychology and biology. It has made great strides in the last 100 years, during which many aspects of the physiology, biochemistry, pharmacology and structure of the vertebrate brain have been understood. Understanding of some of the basic perceptual, cognitive, attentional, emotional and mnemonic functions is also making progress, particularly since the advent of the cognitive neurosciences, which focus specifically on understanding higher level processes of cognition via imaging technology. Neuroimaging has enabled scientists to study the human brain at work in vivo, deepening our understanding of the very complex processes underpinning speech and language, thinking and reasoning, reading and mathematics. It seems timely, therefore, to consider how we might implement our increased understanding of brain development and brain function to explore educational questions.

Few-Layered Black Phosphorus: From Fabrication and Customization to Biomedical Applications.

PubMed

Wang, Huaiyu; Yu, Xue-Feng

2018-02-01

As a new kind of 2D material, black phosphorus has gained increased attention in the past three years. Although few-layered black phosphorus nanosheets (BPs) degrade quickly under ambient conditions to phosphate anions, which greatly hampers their optical and electronic applications, this property also makes BPs highly biocompatible and biodegradable, and is regarded as an advantage for various biomedical applications. This Concept summarizes the state-of-art progresses of BPs, from fabrication and surface modification to biomedical applications. It is expected that BPs with such fascinating properties will encourage more scientists to engage in expanding its biomedical applications by tackling the scientific challenges involved in their development. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Reintroduction of Lake Sturgeon (Acipenser fulvescens) into the St. Regis River, NY: Post-release assessment of habitat use and growth

USGS Publications Warehouse

Dittman, Dawn E.; Chalupnicki, Marc A.; Johnson, James H.; Snyder, James

2015-01-01

One of the depleted endemic fish species of the Great Lakes, Acipenser fulvescens (Lake Sturgeon), has been the target of extensive conservation efforts. One strategy is reintroduction into historically productive waters. The St. Regis River, NY, represents one such adaptive-management effort, with shared management between New York and the St. Regis Mohawk Tribe. Between 1998 and 2004, a total of 4977 young-of-year Lake Sturgeon were released. Adaptive management requires intermediate progress metrics. During 2004 and 2005, we measured growth, habitat use, and survivorship metrics of the released fish. We captured a total of 95 individuals of all stocked ages. Year-class minimal-survival rates ranged from 0.19–2.1%. The size-at-age and length/biomass relationships were comparable to those reported for juveniles in other Great Lakes waters. These intermediate assessment metrics can provide feedback to resource managers who make restoration-program decisions on a much shorter time-scale than the time-frame in which the ultimate goal of a self-sustaining population can be attained.

Accelerated technology transfer: the UK quantum initiative

NASA Astrophysics Data System (ADS)

Bennett, Simon D.

2016-10-01

A new generation of quantum technology based systems, exploiting effects such as superposition and entanglement, will enable widespread, highly disruptive applications which are expected to be of great economic significance. However, the technology is only just emerging from the physics laboratory and generally remains at low TRLs. The question is: where, and when, will this impact be first manifest? The UK, with substantial Government backing, has embarked on an ambitious national program to accelerate the process of technology transfer with the objective of seizing a significant and sustainable share of the future economic benefit for the UK. Many challenges and uncertainties remain but the combined and co-ordinated efforts of Government, Industry and Academia are making great progress. The level of collaboration is unusually high and the goal of embedding a "QT Ecosystem" in the UK looks to be attainable. This paper describes the UK national programme, its key players, and their respective roles. It will illustrate some of the likely first commercial applications and provide a status update. Some of the challenges that might prevent realisation of the goal will be highlighted.

Cryobiotechnology of apple (Malus spp.): development, progress and future prospects.

PubMed

Wang, Min-Rui; Chen, Long; Teixeira da Silva, Jaime A; Volk, Gayle M; Wang, Qiao-Chun

2018-05-01

Cryopreservation provides valuable genes for further breeding of elite cultivars, and cryotherapy improves the production of virus-free plants in Malus spp., thus assisting the sustainable development of the apple industry. Apple (Malus spp.) is one of the most economically important temperate fruit crops. Wild Malus genetic resources and existing cultivars provide valuable genes for breeding new elite cultivars and rootstocks through traditional and biotechnological breeding programs. These valuable genes include those resistant to abiotic factors such as drought and salinity, and to biotic factors such as fungi, bacteria and aphids. Over the last three decades, great progress has been made in apple cryobiology, making Malus one of the most extensively studied plant genera with respect to cryopreservation. Explants such as pollen, seeds, in vivo dormant buds, and in vitro shoot tips have all been successfully cryopreserved, and large Malus cryobanks have been established. Cryotherapy has been used for virus eradication, to obtain virus-free apple plants. Cryopreservation provided valuable genes for further breeding of elite cultivars, and cryotherapy improved the production of virus-free plants in Malus spp., thus assisting the sustainable development of the apple industry. This review provides updated and comprehensive information on the development and progress of apple cryopreservation and cryotherapy. Future research will reveal new applications and uses for apple cryopreservation and cryotherapy.

Insisting on Digital Equity: Reframing the Dominant Discourse on Multicultural Education and Technology

ERIC Educational Resources Information Center

Gorski, Paul C.

2009-01-01

In the United States, where technological progress is portrayed as humanistic progress, computer technologies often are hailed as the great equalizers. Even within progressive education movements, such as multicultural education, the conversation about instructional technology tends to center more on this or that wonderful Web site or piece of…

School Improvement Grants: Progress Report from America's Great City Schools

ERIC Educational Resources Information Center

Council of the Great City Schools, 2015

2015-01-01

This report measures trends in performance among urban schools receiving federal School Improvement Grant (SIG) awards as part of the American Recovery and Reinvestment Act of 2009 (ARRA). The Council of the Great City Schools aims to document how member districts of the Council of the Great City Schools implemented SIG and specifically what…

Great Basin Native Plant Selection and Increase Project: 2012 progress report

Treesearch

Nancy Shaw; Mike Pellant

2013-01-01

The Interagency Native Plant Materials Development Program outlined in the 2002 USDA and USDI Report to Congress, USDI Bureau of Land Management programs and policies, and the Great Basin Restoration Initiative encourage the use of native species for rangeland rehabilitation and restoration where feasible. The Great Basin Native Plant Selection and Increase Project was...

Nanomaterials with enzyme-like characteristics (nanozymes): next-generation artificial enzymes.

PubMed

Wei, Hui; Wang, Erkang

2013-07-21

Over the past few decades, researchers have established artificial enzymes as highly stable and low-cost alternatives to natural enzymes in a wide range of applications. A variety of materials including cyclodextrins, metal complexes, porphyrins, polymers, dendrimers and biomolecules have been extensively explored to mimic the structures and functions of naturally occurring enzymes. Recently, some nanomaterials have been found to exhibit unexpected enzyme-like activities, and great advances have been made in this area due to the tremendous progress in nano-research and the unique characteristics of nanomaterials. To highlight the progress in the field of nanomaterial-based artificial enzymes (nanozymes), this review discusses various nanomaterials that have been explored to mimic different kinds of enzymes. We cover their kinetics, mechanisms and applications in numerous fields, from biosensing and immunoassays, to stem cell growth and pollutant removal. We also summarize several approaches to tune the activities of nanozymes. Finally, we make comparisons between nanozymes and other catalytic materials (other artificial enzymes, natural enzymes, organic catalysts and nanomaterial-based catalysts) and address the current challenges and future directions (302 references).

Progress in the Development of SERS-Active Substrates Based on Metal-Coated Porous Silicon

PubMed Central

Girel, Kseniya V.; Panarin, Andrei; Terekhov, Sergei N.

2018-01-01

The present work gives an overview of the developments in surface-enhanced Raman scattering (SERS) with metal-coated porous silicon used as an active substrate. We focused this review on the research referenced to SERS-active materials based on porous silicon, beginning from the patent application in 2002 and enclosing the studies of this year. Porous silicon and metal deposition technologies are discussed. Since the earliest studies, a number of fundamentally different plasmonic nanostructures including metallic dendrites, quasi-ordered arrays of metallic nanoparticles (NPs), and metallic nanovoids have been grown on porous silicon, defined by the morphology of this host material. SERS-active substrates based on porous silicon have been found to combine a high and well-reproducible signal level, storage stability, cost-effective technology and handy use. They make it possible to identify and study many compounds including biomolecules with a detection limit varying from milli- to femtomolar concentrations. The progress reviewed here demonstrates the great prospects for the extensive use of the metal-coated porous silicon for bioanalysis by SERS-spectroscopy. PMID:29883382

Automating Individualized Formative Feedback in Large Classes Based on a Directed Concept Graph

PubMed Central

Schaffer, Henry E.; Young, Karen R.; Ligon, Emily W.; Chapman, Diane D.

2017-01-01

Student learning outcomes within courses form the basis for course completion and time-to-graduation statistics, which are of great importance in education, particularly higher education. Budget pressures have led to large classes in which student-to-instructor interaction is very limited. Most of the current efforts to improve student progress in large classes, such as “learning analytics,” (LA) focus on the aspects of student behavior that are found in the logs of Learning Management Systems (LMS), for example, frequency of signing in, time spent on each page, and grades. These are important, but are distant from providing help to the student making insufficient progress in a course. We describe a computer analytical methodology which includes a dissection of the concepts in the course, expressed as a directed graph, that are applied to test questions, and uses performance on these questions to provide formative feedback to each student in any course format: face-to-face, blended, flipped, or online. Each student receives individualized assistance in a scalable and affordable manner. It works with any class delivery technology, textbook, and learning management system. PMID:28293202

Reaction chemistry in rechargeable Li-O2 batteries.

PubMed

Lim, Hee-Dae; Lee, Byungju; Bae, Youngjoon; Park, Hyeokjun; Ko, Youngmin; Kim, Haegyeom; Kim, Jinsoo; Kang, Kisuk

2017-05-22

The seemingly simple reaction of Li-O 2 batteries involving lithium and oxygen makes this chemistry attractive for high-energy-density storage systems; however, achieving this reaction in practical rechargeable Li-O 2 batteries has proven difficult. The reaction paths leading to the final Li 2 O 2 discharge products can be greatly affected by the operating conditions or environment, which often results in major side reactions. Recent research findings have begun to reveal how the reaction paths may be affected by the surrounding conditions and to uncover the factors contributing to the difficulty in achieving the reactions of lithium and oxygen. This progress report describes the current state of understanding of the electrode reaction mechanisms in Li-O 2 batteries; the factors that affect reaction pathways; and the effect of cell components such as solvents, salts, additives, and catalysts on the discharge product and its decomposition during charging. This comprehensive review of the recent progress in understanding the reaction chemistry of the Li-O 2 system will serve as guidelines for future research and aid in the development of reliable high-energy-density rechargeable Li-O 2 batteries.

Progress in the Development of SERS-Active Substrates Based on Metal-Coated Porous Silicon.

PubMed

Bandarenka, Hanna V; Girel, Kseniya V; Zavatski, Sergey A; Panarin, Andrei; Terekhov, Sergei N

2018-05-21

The present work gives an overview of the developments in surface-enhanced Raman scattering (SERS) with metal-coated porous silicon used as an active substrate. We focused this review on the research referenced to SERS-active materials based on porous silicon, beginning from the patent application in 2002 and enclosing the studies of this year. Porous silicon and metal deposition technologies are discussed. Since the earliest studies, a number of fundamentally different plasmonic nanostructures including metallic dendrites, quasi-ordered arrays of metallic nanoparticles (NPs), and metallic nanovoids have been grown on porous silicon, defined by the morphology of this host material. SERS-active substrates based on porous silicon have been found to combine a high and well-reproducible signal level, storage stability, cost-effective technology and handy use. They make it possible to identify and study many compounds including biomolecules with a detection limit varying from milli- to femtomolar concentrations. The progress reviewed here demonstrates the great prospects for the extensive use of the metal-coated porous silicon for bioanalysis by SERS-spectroscopy.

Synthetic Genomics and Synthetic Biology Applications Between Hopes and Concerns

PubMed Central

König, Harald; Frank, Daniel; Heil, Reinhard; Coenen, Christopher

2013-01-01

New organisms and biological systems designed to satisfy human needs are among the aims of synthetic genomics and synthetic biology. Synthetic biology seeks to model and construct biological components, functions and organisms that do not exist in nature or to redesign existing biological systems to perform new functions. Synthetic genomics, on the other hand, encompasses technologies for the generation of chemically-synthesized whole genomes or larger parts of genomes, allowing to simultaneously engineer a myriad of changes to the genetic material of organisms. Engineering complex functions or new organisms in synthetic biology are thus progressively becoming dependent on and converging with synthetic genomics. While applications from both areas have been predicted to offer great benefits by making possible new drugs, renewable chemicals or clean energy, they have also given rise to concerns about new safety, environmental and socio-economic risks – stirring an increasingly polarizing debate. Here we intend to provide an overview on recent progress in biomedical and biotechnological applications of synthetic genomics and synthetic biology as well as on arguments and evidence related to their possible benefits, risks and governance implications. PMID:23997647

Potentially malignant disorders of the oral cavity: a clinical study.

PubMed

Shukla, Anirudh

2014-01-01

Oral cancers in India, unlike in the West are the most common cancers encountered, be it a primary or a tertiary referral practice. This makes the study and management of these cancers an important issue especially for the otolaryngologist. It is well known that the most common variant of oral cancers is the squamous cell carcinoma. Also the etiology is well established; with tobacco use in both smoking and smokeless forms, alcohol, betel nut and recently the Human Papilloma virus infection being implicated. Certain conditions which definitely increase the probability of getting oral cancers are known and this study aims in revisiting these aspects of pre-malignancy. The progression from a pre-cancerous lesion/condition to frank cancer is well established across many studies and many specialties. Also timely recognizing these pre-cancerous conditions and administration of proper treatment will greatly help in reducing the morbidity and mortality from subsequent much advanced and dangerous oral cancer. Keeping these facts in mind this study was planned to study the established pre-cancerous lesions which are known to progress to oral cancers.

Challenges and progress in making DNA-based AIS early ...

EPA Pesticide Factsheets

The ability of DNA barcoding to find additional species in hard-to-sample locations or hard-to-identify samples is well established. Nevertheless, adoption of DNA barcoding into regular monitoring programs has been slow, in part due to issues of standardization and interpretation that need resolving. In this presentation, we describe our progress towards incorporating DNA-based identification into broad-spectrum aquatic invasive species early-detection monitoring in the Laurentian Great Lakes. Our work uses community biodiversity information as the basis for evaluating survey performance for various taxonomic groups. Issues we are tackling in bringing DNA-based data to bear on AIS monitoring design include: 1) Standardizing methodology and work flow from field collection and sample handling through bioinformatics post-processing; 2) Determining detection sensitivity and accounting for inter-species differences in DNA amplification and primer affinity; 3) Differentiating sequencing and barcoding errors from legitimate new finds when range and natural history information is limited; and 4) Accounting for the different nature of morphology- vs. DNA-based biodiversity information in subsequent analysis (e.g., via species accumulation curves, multi-metric indices). not applicable

Recent advances and product enhancements in reflective cholesteric displays

NASA Astrophysics Data System (ADS)

Khan, Asad; Schneider, Tod; Miller, Nick; Marhefka, Duane; Ernst, Todd; Nicholson, Forrest; Doane, Joseph W.

2005-04-01

Bistable reflective cholesteric displays are a liquid crystal display technology developed to fill a market need for very low power displays on a low-cost, high resolution passive matrix. Their unique look, high reflectivity, bistability, and simple structure make them an ideal flat panel display choice for handheld or other portable devices where small lightweight batteries with long lifetimes are important. We discuss recent advances in cholesteric display technology at Kent Displays such as progress towards single layer black and white displays, standard products, lower cost display modules, and various interface options for cholesteric display applications. It will be shown that inclusion of radio frequency (rf) control options and serial peripheral interface (spi) can greatly enhance the cholesteric display module market penetration by enabling quick integration into end devices. Finally, some discussion will be on the progress of the development of flexible reflective cholesteric displays. These flexible displays can dramatically change industrial design methods by enabling curved surfaces with displays integrated in them. Additional discussion in the paper will include applications of various display modes including signs, hand held instrumentation, and the electronic book and reader.

Advances in the management of orbital fractures.

PubMed

Nguyen, P N; Sullivan, P

1992-01-01

Great progress has been made in both the basic science and the clinical knowledge base used in orbital reconstruction. With this, increasing complex orbital reconstructive problems are better managed. The diagnosis, treatment plan, and the actual reconstruction have evolved to a higher level. Several areas of progress are of note: the greater appreciation of the intimate relation between the bony orbit's shape and the position of the globe; application of computer technology in orbital injuries; effect of rigid fixation on autogenous and alloplastic graft; and the use of advanced biocompatible synthetic materials in orbital reconstruction. Although this progress has great impact on treatment of orbital injuries, there are many unanswered challenges in the treatment of the fragile frame of the window to the human soul.

Decision-making tools in prostate cancer: from risk grouping to nomograms.

PubMed

Fontanella, Paolo; Benecchi, Luigi; Grasso, Angelica; Patel, Vipul; Albala, David; Abbou, Claude; Porpiglia, Francesco; Sandri, Marco; Rocco, Bernardo; Bianchi, Giampaolo

2017-12-01

Prostate cancer (PCa) is the most common solid neoplasm and the second leading cause of cancer death in men. After the Partin tables were developed, a number of predictive and prognostic tools became available for risk stratification. These tools have allowed the urologist to better characterize this disease and lead to more confident treatment decisions for patients. The purpose of this study is to critically review the decision-making tools currently available to the urologist, from the moment when PCa is first diagnosed until patients experience metastatic progression and death. A systematic and critical analysis through Medline, EMBASE, Scopus and Web of Science databases was carried out in February 2016 as per the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. The search was conducted using the following key words: "prostate cancer," "prediction tools," "nomograms." Seventy-two studies were identified in the literature search. We summarized the results into six sections: Tools for prediction of life expectancy (before treatment), Tools for prediction of pathological stage (before treatment), Tools for prediction of survival and cancer-specific mortality (before/after treatment), Tools for prediction of biochemical recurrence (before/after treatment), Tools for prediction of metastatic progression (after treatment) and in the last section biomarkers and genomics. The management of PCa patients requires a tailored approach to deliver a truly personalized treatment. The currently available tools are of great help in helping the urologist in the decision-making process. These tests perform very well in high-grade and low-grade disease, while for intermediate-grade disease further research is needed. Newly discovered markers, genomic tests, and advances in imaging acquisition through mpMRI will help in instilling confidence that the appropriate treatments are being offered to patients with prostate cancer.

Decision Making in Rangelands: An Integrated Modeling Approach to Resilience and Change

NASA Astrophysics Data System (ADS)

Galvin, K. A.; Ojima, D. S.; Boone, R. B.

2007-12-01

Rangelands comprise approximately 25% of the earth's surface and these landscapes support more than 20 million people and most of the world's charismatic megafauna. Most of the people who live in these regions of the world herd domestic livestock and some do limited cultivation so they are dependent directly on the environment for their livelihoods. But change is rapidly changing the environments upon which these people depend through such factors as population pressures, land use and land tenure changes, climate variability, and policy changes which fragment their resources and thus their ability to earn a living. How can we understand change in this linked human-environment system? The study of complex biophysical and human systems can be greatly assisted by appropriate simulation models that integrate what is known about ecological and human decision-making processes. We have developed an integrated modeling system for Kajiado, Kenya where land use management decisions have implications for economics and the ecosystem. In this paper we look at how land use decisions, that is, livestock movement patterns have implications for societal economics and ecosystem services. Research that focuses on local behavior is important because it is at that level where fundamental decisions are made regarding events like extreme climate and changes such as land tenure policy and it is here where resilience is manifested. The notion that broad recommendation domains can be identified for a broad set of people and large regions coping with change is becoming increasingly hard to trust given the spatial and temporal heterogeneity of the systems we are looking at, and the complexity of the world we now live in. Why is this important? The only way the research community is going to make great progress in attaining objectives that do confer resilience (on social and ecological systems) is through much better targeting ability, a large part of which seem to be intimately entwined with understanding how make decisions are made at the local level.

Decision Making Styles and Progress in Occupational Decision Making.

ERIC Educational Resources Information Center

Phillips, Susan D.; And Others

1984-01-01

Examined the role of rational, intuitive, and dependent decisional strategies in facilitating decisions about postcollege occupation among college students (N=71). Results indicated that the use of a dependent decision-making style was the single most powerful predictor of progress. (LLL)

Anomalous Stars and Where to Find Them

NASA Astrophysics Data System (ADS)

Muna, Demitri; Huff, Eric

2018-01-01

The sky is now extensively mapped by imaging surveys in wavelengths that span the electromagnetic spectrum, ranging from Fermi and GALEX down to WISE, Planck, and radio surveys like FIRST and VLSS. Individual public catalogs now contain on order hundreds of millions of distinct sources. Recent progress in image analysis techniques makes possible great increases in the efficiency, sensitivity, and reliability of measurements that combine imaging data from multiple probes with heterogeneous properties. This is especially true for the identification of anomalous sources: traditional methods for finding ‘outliers’ typically rely on making hard cuts on noisy catalog properties, greatly restricting the potential discovery space. Cross-catalog matches confine investigation to objects that occur at signal-to-noise ratios sufficient to be independently detectable in a subset of all the available multi-wavelength coverage. The process of merging the latest analyses with existing data is severely hampered, however, by the fractured way in which these data are processed and stored, limitations of data access, the data volume involved, and the computation power required. This has left archive data far from fully exploited. Stellar anomalies present the best place to start: joint distributions of stellar colors and magnitudes have finer structures than extended sources, and modelling of point sources is computationally cheaper than for galaxies. We present a framework to solve the problem of applying new algorithms to old data while overcoming the limitations described above, in the search for the undiscovered anomalous.

Decision-Making Accuracy of CBM Progress-Monitoring Data

ERIC Educational Resources Information Center

Hintze, John M.; Wells, Craig S.; Marcotte, Amanda M.; Solomon, Benjamin G.

2018-01-01

This study examined the diagnostic accuracy associated with decision making as is typically conducted with curriculum-based measurement (CBM) approaches to progress monitoring. Using previously published estimates of the standard errors of estimate associated with CBM, 20,000 progress-monitoring data sets were simulated to model student reading…

The development of structural x-ray crystallography

NASA Astrophysics Data System (ADS)

Woolfson, M. M.

2018-03-01

From its birth in 1912, when only the simplest structures could be solved, x-ray structural crystallography is now able to solve macromolecular structures containing many thousands of independent non-hydrogen atoms. This progress has depended on, and been driven by, great technical advances in the development of powerful synchrotron x-ray sources, advanced automated equipment for the collection and storage of large data sets and powerful computers to deal with everything from data processing to running programmes employing complex algorithms for the automatic solution of structures. The sheer number of developments in the subject over the past century makes it impossible for this review to be exhaustive, but it will describe some major developments that will enable the reader to understand how the subject has grown from its humble beginnings to what it is today.

Nanoplasmonics: a frontier of photovoltaic solar cells

NASA Astrophysics Data System (ADS)

Gu, Min; Ouyang, Zi; Jia, Baohua; Stokes, Nicholas; Chen, Xi; Fahim, Narges; Li, Xiangping; Ventura, Michael James; Shi, Zhengrong

2012-12-01

Nanoplasmonics recently has emerged as a new frontier of photovoltaic research. Noble metal nanostructures that can concentrate and guide light have demonstrated great capability for dramatically improving the energy conversion efficiency of both laboratory and industrial solar cells, providing an innovative pathway potentially transforming the solar industry. However, to make the nanoplasmonic technology fully appreciated by the solar industry, key challenges need to be addressed; including the detrimental absorption of metals, broadband light trapping mechanisms, cost of plasmonic nanomaterials, simple and inexpensive fabrication and integration methods of the plasmonic nanostructures, which are scalable for full size manufacture. This article reviews the recent progress of plasmonic solar cells including the fundamental mechanisms, material fabrication, theoretical modelling and emerging directions with a distinct emphasis on solutions tackling the above-mentioned challenges for industrial relevant applications.

Progress in combating cigarette smuggling: controlling the supply chain.

PubMed

Joossens, L; Raw, M

2008-12-01

The illicit tobacco trade results in huge losses of revenue to governments, estimated at $US40-50 billion in 2006, and in increased consumption and thus health problems because it makes tobacco available more cheaply. On 20 October 2008 the second meeting of the International Negotiating Body (INB2) on the illicit trade protocol of WHO's Framework Convention on Tobacco Control (FCTC) will discuss measures to tackle the illicit trade in tobacco products. This paper presents the experience over the last decade of three countries, Italy, Spain and the United Kingdom, which shows that tobacco smuggling can be successfully tackled. The evidence strongly suggests that the key to controlling smuggling is controlling the supply chain, and that the supply chain is controlled to a great extent by the tobacco industry.

Do Old Ladies Make World History?: Student Perceptions of Elder Female Agency

ERIC Educational Resources Information Center

Woodbum, Stephen M.

2006-01-01

In this article, the author shares the views of his undergraduate students regarding elder female agency and their answers to the question: "Do old ladies make world history?" Because his undergraduate students mostly view the past in terms of the Great Man theory of history, which holds that those who make history are necessarily great,…

Building a reference inventory of Great Lakes aquatic fauna

EPA Science Inventory

Despite the existence of numerous publications and web-pages that address aspects of species composition and distribution in the Great Lakes, there is at present no single resource that brings all this information together. This poster describes our progress towards generating a ...

Plans and progress for building a Great Lakes fauna DNA barcode reference library

EPA Science Inventory

DNA reference libraries provide researchers with an important tool for assessing regional biodiversity by allowing unknown genetic sequences to be assigned identities, while also providing a means for taxonomists to validate identifications. Expanding the representation of Great...

The data of geochemistry

USGS Publications Warehouse

Clarke, Frank Wigglesworth

1924-01-01

Upon the subject of geochemistry a vast literature exists, but it is widely scattered and portions of it are difficult of access. The general treatises, like the classical works of Bischof and of Koth, are not recent, and great masses of modern data are as yet uncorrelated. The American material alone is singularly rich, but most of it has been accumulated since Roth's treatise was published. The science of chemistry, moreover, has undergone great changes during the last 25 years, and many subjects now appear under new and generally unfamiliar aspects. The methods and principles of physical chemistry are being more and more applied to the solution of geochemical problems,1 as is shown by the well-known researches of Van't Hoff upon the Stassfurt salts and the magmatic studies of Vogt, Doelter, and others. The great work in progress at the geophysical laboratory of the Carnegie Institution is another illustration of the change now taking place in geochemical investigation. To bring some of the data together, to formulate a few of the problems and to present certain general conclusions in their modern form are the purposes of this memoir. It is not an exhaustive monograph upon geochemistry, but rather a critical summary of what is now known, and a guide to the more important literature of the subject. If it does no more than to make existing data available to the reader, its preparation will be justified.

Hanahau'oli School: Theory Meets Practice

ERIC Educational Resources Information Center

Peters, Robert

2015-01-01

Progressive schools, by their very nature, need to respond to changing societal conditions. Within that context, learning guided by the teachings of John Dewey will not only make the progressive tradition sustainable but also make it increasingly relevant in a future that will increasingly make demands on students to possess the knowledge to…

High expression of insulin receptor on tumour-associated blood vessels in invasive bladder cancer predicts poor overall and progression-free survival.

PubMed

Roudnicky, Filip; Dieterich, Lothar C; Poyet, Cedric; Buser, Lorenz; Wild, Peter; Tang, Dave; Camenzind, Peter; Ho, Chien Hsien; Otto, Vivianne I; Detmar, Michael

2017-06-01

Bladder cancer is a frequently recurring disease with a very poor prognosis once progressed to invasive stages, and tumour-associated blood vessels play a crucial role in this process. In order to identify novel biomarkers associated with progression, we isolated blood vascular endothelial cells (BECs) from human invasive bladder cancers and matched normal bladder tissue, and found that tumour-associated BECs greatly up-regulated the expression of insulin receptor (INSR). High expression of INSR on BECs of invasive bladder cancers was significantly associated with shorter progression-free and overall survival. Furthermore, increased expression of the INSR ligand IGF-2 in invasive bladder cancers was associated with reduced overall survival. INSR may therefore represent a novel biomarker to predict cancer progression. Mechanistically, we observed pronounced hypoxia in human bladder cancer tissue, and found a positive correlation between the expression of the hypoxia marker gene GLUT1 and vascular INSR expression, indicating that hypoxia drives INSR expression in tumour-associated blood vessels. In line with this, exposure of cultured BECs and human bladder cancer cell lines to hypoxia led to increased expression of INSR and IGF-2, respectively, and IGF-2 increased BEC migration through the activation of INSR in vitro. Taken together, we identified vascular INSR expression as a potential biomarker for progression in bladder cancer. Furthermore, our data suggest that IGF-2/INSR mediated paracrine crosstalk between bladder cancer cells and endothelial cells is functionally involved in tumour angiogenesis and may thus represent a new therapeutic target. Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

Models in animal collective decision-making: information uncertainty and conflicting preferences

PubMed Central

Conradt, Larissa

2012-01-01

Collective decision-making plays a central part in the lives of many social animals. Two important factors that influence collective decision-making are information uncertainty and conflicting preferences. Here, I bring together, and briefly review, basic models relating to animal collective decision-making in situations with information uncertainty and in situations with conflicting preferences between group members. The intention is to give an overview about the different types of modelling approaches that have been employed and the questions that they address and raise. Despite the use of a wide range of different modelling techniques, results show a coherent picture, as follows. Relatively simple cognitive mechanisms can lead to effective information pooling. Groups often face a trade-off between decision accuracy and speed, but appropriate fine-tuning of behavioural parameters could achieve high accuracy while maintaining reasonable speed. The right balance of interdependence and independence between animals is crucial for maintaining group cohesion and achieving high decision accuracy. In conflict situations, a high degree of decision-sharing between individuals is predicted, as well as transient leadership and leadership according to needs and physiological status. Animals often face crucial trade-offs between maintaining group cohesion and influencing the decision outcome in their own favour. Despite the great progress that has been made, there remains one big gap in our knowledge: how do animals make collective decisions in situations when information uncertainty and conflict of interest operate simultaneously? PMID:23565335

The 2005 Thomas Willis Lecture: stroke and vascular cognitive impairment: a transdisciplinary, translational and transactional approach.

PubMed

Hachinski, Vladimir

2007-04-01

Advances in stroke are occurring at an unprecedented pace, but often in disciplinary isolation and without optimal mechanisms for systematically translating, integrating and applying the findings. Knowledge accrues in pieces, but is understood in patterns. To optimize knowledge acquisition and application, infrastructures and systems need to be set up along with appealing incentives. The approach needs to be transdisciplinary, going beyond the bounds of any given discipline, reciprocally translational, and transactional, meaning that the interchanges have to yield previously agreed benefits to the parties (The Triple T Approach). A new breed of leaders needs to be developed and nurtured to catalyze the process. Opportunities abound. Stroke and most brain diseases share the same pathophysiological fundamental mechanisms. An integrated, systematic approach to these processes could yield not only greater understanding but new, common therapeutic targets for several diseases. Biphasic clinical trials could combine the best features of pragmatic and explanatory, randomized clinical trials. The greatest opportunity of all may be the largely under-explored and under-exploited borderlands between cerebrovascular and Alzheimer disease. One in three of us will have a stroke, become demented, or both. For each person who has a stroke or Alzheimer disease, two have some cognitive impairment short of dementia, often subclinical cerebrovascular disease on a substrate of Alzheimer changes. The fact that cerebrovascular and Alzheimer disease share the same risk factors, provide a great opportunity for prevention, if implemented at the "brain at risk" stage. Systematically integrating what we know and evaluating what we do could spur progress. Research is not only an activity but an attitude. Making evaluation and incentives to excel part of the funding of all stroke activities would yield far ranging cumulative improvements in all aspects of stroke. No system can replace the individual initiative, creativity and insights that lead to the great discoveries, but progress is not made by breakthroughs alone. No one's work is so exalted that it cannot be improved, nor so humble that it has no value. We can all make a difference.

Preventing Breast Cancer: Making Progress

MedlinePlus

... Navigation Bar Home Current Issue Past Issues Preventing Breast Cancer: Making Progress Past Issues / Fall 2006 Table of ... 000 women will have been diagnosed with invasive breast cancer, and nearly 41,000 women will die from ...

Creating a 21st-century intelligent health system.

PubMed

Newt, Gingrich; Nancy, Desmond

2008-02-01

In most areas of life, Americans enjoy the ease and convenience offered by advances in technology, communications, and transportation. Every day we experience the 21st-century model of America, which is one of effectiveness, accuracy, speed, flexibility, efficiency, lower cost, more choices, and greater achievement. We can shop online, compare prices for goods and services, and when decisions need to be made, we have access to a wide array of information sources to assist in making those decisions. In short, Americans enjoy great latitude in our power to determine what is best for us. This is not, however, the case when it comes to health and healthcare. In our current healthcare system, individuals are dependent on a structure that has resisted the natural progress and modernization achieved by market-oriented, 21st-century industries. The information age has been leaving health behind. Although it is the nature of a science- and technology-based entrepreneurial free market to provide more choices of higher quality at lower cost, in the healthcare sector, prices continue to rise, quality is inconsistent, and individuals lack the information, incentives, and power to make choices.

Effective behavioral modeling and prediction even when few exemplars are available

NASA Astrophysics Data System (ADS)

Goan, Terrance; Kartha, Neelakantan; Kaneshiro, Ryan

2006-05-01

While great progress has been made in the lowest levels of data fusion, practical advances in behavior modeling and prediction remain elusive. The most critical limitation of existing approaches is their inability to support the required knowledge modeling and continuing refinement under realistic constraints (e.g., few historic exemplars, the lack of knowledge engineering support, and the need for rapid system deployment). This paper reports on our ongoing efforts to develop Propheteer, a system which will address these shortcomings through two primary techniques. First, with Propheteer we abandon the typical consensus-driven modeling approaches that involve infrequent group decision making sessions in favor of an approach that solicits asynchronous knowledge contributions (in the form of alternative future scenarios and indicators) without burdening the user with endless certainty or probability estimates. Second, we enable knowledge contributions by personnel beyond the typical core decision making group, thereby casting light on blind spots, mitigating human biases, and helping maintain the currency of the developed behavior models. We conclude with a discussion of the many lessons learned in the development of our prototype Propheteer system.

Remediation to restoration to revitalization: A path forward for AOCs progress report

EPA Science Inventory

At the 2016 Great Lakes Areas of Concern (AOC) Conference, researchers from the USEPA Office of Research and Development (ORD) sparked conversation about community revitalization and the different states of progress throughout the basin. The conversation was meant to provide AOC ...

Coastal wetland support of Great Lakes fisheries: progress from concept to quantification.

EPA Science Inventory

Fishery support is recognized as a valuable ecosystem service provided by aquatic systems but is harder to quantify than to describe conceptually. In this paper, we intersect data on fish inhabiting Great Lakes coastal wetlands with information on commercial and recreational har...

Creating Smarter Classrooms: Data-Based Decision Making for Effective Classroom Management

ERIC Educational Resources Information Center

Gage, Nicholas A.; McDaniel, Sara

2012-01-01

The term "data-based decision making" (DBDM) has become pervasive in education and typically refers to the use of data to make decisions in schools, from assessment of an individual student's academic progress to whole-school reform efforts. Research suggests that special education teachers who use progress monitoring data (a DBDM…

Slices of Jupiter's Great Red Spot

NASA Image and Video Library

2017-12-11

This figure shows data from the six channels of the microwave radiometer (MWR) instrument onboard NASA's Juno spacecraft. The data were collected in the mission's sixth science orbit (referred to as "perijove 7"), during which the spacecraft passed over Jupiter's Great Red Spot. The top layer in the figure is a visible light image from the mission's JunoCam instrument, provided for context. The MWR instrument enables Juno to see deeper into Jupiter than any previous spacecraft or Earth-based observations. Each MWR channel peers progressively deeper below the visible cloud tops. Channel 1 is sensitive to longer microwave wavelengths; each of the other channels is sensitive to progressively shorter wavelengths. The large-scale structure of the Great Red Spot is visible in the data as deep into Jupiter as MWR can observe. https://photojournal.jpl.nasa.gov/catalog/PIA22177

[A review of the genomic and gene cloning studies in trees].

PubMed

Yin, Tong-Ming

2010-07-01

Supported by the Department of Energy (DOE) of U.S., the first tree genome, black cottonwood (Populus trichocarpa), has been completely sequenced and publicly release. This is the milestone that indicates the beginning of post-genome era for forest trees. Identification and cloning genes underlying important traits are one of the main tasks for the post-genome-era tree genomic studies. Recently, great achievements have been made in cloning genes coordinating important domestication traits in some crops, such as rice, tomato, maize and so on. Molecular breeding has been applied in the practical breeding programs for many crops. By contrast, molecular studies in trees are lagging behind. Trees possess some characteristics that make them as difficult organisms for studying on locating and cloning of genes. With the advances in techniques, given also the fast growth of tree genomic resources, great achievements are desirable in cloning unknown genes from trees, which will facilitate tree improvement programs by means of molecular breeding. In this paper, the author reviewed the progress in tree genomic and gene cloning studies, and prospected the future achievements in order to provide a useful reference for researchers working in this area.

From SARS to H7N9: the mechanism of responding to emerging communicable diseases has made great progress in China.

PubMed

Yao, Linong; Chen, Enfu; Chen, Zhiping; Gong, Zhenyu

2013-12-01

The outbreak of severe acute respiratory syndrome (SARS) in 2003 indicated that China's existing former mechanism for emergency management was very vulnerable. The Chinese Government has since established a new mechanism for responding to emerging communicable diseases. This paper examined the current status of and developments in China's response to emerging communicable diseases from the outbreak of SARS in 2003 to the outbreak of H7N9 virus infection in 2013. Results indicated that the current mechanism for emergency responses to emerging communicable diseases in China has made great achievements in terms of command and decision-making, organization and collaboration, monitoring and early warning systems, protection, and international communication and cooperation. This mechanism for responding to emerging communicable diseases allowed China to successfully deal with outbreaks of the H5N1 bird flu, H1N1 flu, and H7N9 bird flu. However, a better coordination system, a more complete Office of Responses to Public Health Emergencies, administrative responsibility and error correction, better personnel training, and government responsibility may help to improve the response to emerging communicable diseases. Such improvements are eagerly anticipated.

Gray Wave of the Great Transformation: A Satellite View of Urbanization, Climate Change, and Food Security

NASA Technical Reports Server (NTRS)

Imhoff, Marc Lee; Kamiell, Arnon Menahem

2010-01-01

Land cover change driven by human activity is profoundly affecting Earth's natural systems with impacts ranging from a loss of biological diversity to changes in regional and global climate. This change has been so pervasive and progressed so rapidly, compared to natural processes, scientists refer to it as "the great transformation". Urbanization or the 'gray wave' of land transformation is being increasingly recognized as an important process in global climate change. A hallmark of our success as a species, large urban conglomerates do in fact alter the land surface so profoundly that both local climate and the basic ecology of the landscape are affected in ways that have consequences to human health and economic well-being. Fortunately we have incredible new tools for planning and developing urban places that are both enjoyable and sustainable. A suite of Earth observing satellites is making it possible to study the interactions between urbanization, biological processes, and weather and climate. Using these Earth Observatories we are learning how urban heat islands form and potentially ameliorate them, how urbanization can affect rainfall, pollution, and surface water recharge at the local level and climate and food security globally.

Strategies in transition

NASA Technical Reports Server (NTRS)

Diaz, Alphonso V.

1993-01-01

A new vision has emerged within the Office of Space Science and Applications (OSSA), and within the agency as a whole, for how to design missions to be responsive to the changing budget environment of the 1990s. The overall space science and applications program had to be looked at, restructuring the most expensive and complex projects to bring down costs and ensure their place in the mission queue of the future. The recent restructuring of some of OSSA's largest programs in development and the work to improve efficiency for those in operation is part of OSSA's effort to free funds for more frequent space science missions in the future. Instead of more great observatories, we are looking toward a new vision encompassing a level of great activity through small, frequent missions. The strategy developed for attaining this vision was to lower costs by reducing size and complexity through new technology, while at the same time making progress in space science. The strategy comprises two interwoven parts: the flight program strategy of each of the science disciplines and OSSA's new-technology strategy. The overall purpose of all OSSA's efforts to date has been to free resources for maximizing the space science program in a tough fiscal environment.

Progress towards an AIS early detection monitoring network for the Great Lakes

EPA Science Inventory

As an invasion prone location, the lower St. Louis River system (SLR) has been a case study for ongoing research to develop the framework for a practical Great Lakes monitoring network for early detection of aquatic invasive species (AIS). Early detection, however, necessitates f...

Great Basin Native Plant Project: 2015 Progress Report

Treesearch

Francis Kilkenny; Fred Edwards; Alexis Malcomb

2016-01-01

The Interagency Native Plant Materials Development Program outlined in the 2002 United States Department of Agriculture (USDA) and United States Department of Interior (USDI) Report to Congress encouraged use of native plant materials for rangeland rehabilitation and restoration where feasible. The Great Basin Native Plant Project is a cooperative project lead...

Progress towards design elements for a Great Lakes-wide aquatic invasive species early detection network

EPA Science Inventory

Great Lakes coastal systems are vulnerable to introduction of a wide variety of non-indigenous species (NIS), and the desire to effectively respond to future invaders is prompting efforts towards establishing a broad early-detection network. Such a network requires statistically...

Applying the collective impact approach to address non-native species: A case study of the Great Lakes Phragmites Collaborative

USGS Publications Warehouse

Braun, H. B.; Kowalski, Kurt P.; Hollins, K.

2016-01-01

To address the invasion of non-native Phragmites in the Great Lakes, researchers at the U.S. Geological Survey—Great Lakes Science Center partnered with the Great Lakes Commission in 2012 to establish the Great Lakes Phragmites Collaborative (GLPC). The GLPC is a regional-scale partnership established to improve collaboration among stakeholders and increase the effectiveness of non-native Phragmites management and research. Rather than forming a traditional partnership with a narrowly defined goal, the GLPC follows the principles of collective impact to engage stakeholders, guide progress, and align resources to address this complex, regional challenge. In this paper, the concept and tenets of collective impact are described, the GLPC is offered as a model for other natural resource-focused collective impact efforts, and steps for establishing collaboratives are presented. Capitalizing on the interactive collective impact approach, the GLPC is moving toward a broadly accepted common agenda around which agencies and individuals will be able to better align their actions and generate measureable progress in the regional campaign to protect healthy, diverse ecosystems from damage caused by non-native Phragmites.

MicroRNA in Development and in the Progression of Cancer | Center for Cancer Research

Cancer.gov

MicroRNA in Development and in the Progression of Cancer is divided into three parts. It provides a more complete understanding of miRNA function, summarizes the recent progress, and provides insights by which miRNAs regulate normal development and diseases (including cancers) and the fate of stem cells. It also presents the prospect of the great potential of miRNAs in cancer

Sociotechnical Challenges and Progress in Using Social Media for Health

PubMed Central

Cavusoglu, Hasan; Frisch, Larry; Fels, Sidney

2013-01-01

Social media tools that connect patients, caregivers, and health providers offer great potential for helping people access health advice, receive and give social support, manage or cope with chronic conditions, and make day-to-day health decisions. These systems have seen widespread adoption, but often fail to support the goals as fully as designers and users would like. Through Ackerman’s lens of the “sociotechnical gap” and computer supported cooperative work (CSCW) as a science of the artificial, we review contemporary sociotechnical challenges and progress for using social media to support health. These challenges include a tension between privacy and sharing, policy information credibility, accessibility, and tailoring in social spaces. Those studying, building, deploying, and using social media systems to further health goals will benefit from approaching this work by borrowing from Ackerman’s framing of CSCW. In particular, this requires acknowledgment that technical systems will not fully meet our social goals, and then adopting design and educational approaches that are appropriate to fill this gap, building less-nuanced systems as partial solutions and tools for advancing our understanding, and by working with the CSCW research community to develop and pursue key lines of inquiry. PMID:24148206

Preferences for care towards the end of life when decision-making capacity may be impaired: A large scale cross-sectional survey of public attitudes in Great Britain and the United States.

PubMed

Clarke, Gemma; Fistein, Elizabeth; Holland, Anthony; Barclay, Matthew; Theimann, Pia; Barclay, Stephen

2017-01-01

There is continuing public debate about treatment preferences at the end of life, and the acceptability and legal status of treatments that sustain or end life. However, most surveys use binary yes/no measures, and little is known about preferences in neurological disease when decision-making capacity is lost, as most studies focus on cancer. This study investigates changes in public preferences for care towards the end of life, with a focus on measures to sustain or end life. Large-scale international public opinion surveys using a six-stage patient vignette, respondents chose a level of intervention for each stage as health and decision-making capacity deteriorated. Cross-sectional representative samples of the general public in Great Britain and the USA (N = 2016). Primary outcome measure: changes in respondents' preferences for care, measured on a four-point scale designed before data collection. The scale ranged from: maintaining life at all costs; to intervention with agreement; to no intervention; to measures for ending life. There were no significant differences between GB and USA. Preference for measures to sustain life at all costs peaked at short-term memory loss (30.2%, n = 610). Respondents selecting 'measures to help me die peacefully' increased from 3.9% to 37.0% as the condition deteriorated, with the largest increase occurring when decision-making capacity was lost (10.3% to 23.0%). Predictors of choosing 'measures to help me die peacefully' at any stage were: previous personal experience (OR = 1.34, p<0.010), and older age (OR = 1.09 per decade, p<0.010). Negative predictors: living with children (OR = 0.72, p<0.010) and being of "black" race/ethnicity (OR = 0.45, p<0.001). Public opinion was uniform between GB and USA, but markedly heterogeneous. Despite contemporaneous capacitous consent providing an essential legal safeguard in most jurisdictions, there was a high prevalence of preference for "measures to end my life peacefully" when decision-making capacity was compromised, which increased as dementia progressed. In contrast, a significant number chose preservation of life at all costs, even in end stage dementia. It is challenging to respect the longstanding values of people with dementia concerning either the inviolability of life or personal autonomy, whilst protecting those without decision-making capacity.

Progress in combating cigarette smuggling: controlling the supply chain

PubMed Central

Joossens, L; Raw, M

2008-01-01

Background: The illicit tobacco trade results in huge losses of revenue to governments, estimated at $US40–50 billion in 2006, and in increased consumption and thus health problems because it makes tobacco available more cheaply. On 20 October 2008 the second meeting of the International Negotiating Body (INB2) on the illicit trade protocol of WHO’s Framework Convention on Tobacco Control (FCTC) will discuss measures to tackle the illicit trade in tobacco products. Methods: This paper presents the experience over the last decade of three countries, Italy, Spain and the United Kingdom, which shows that tobacco smuggling can be successfully tackled. Conclusion: The evidence strongly suggests that the key to controlling smuggling is controlling the supply chain, and that the supply chain is controlled to a great extent by the tobacco industry. PMID:18784154

Phthalocyanine-Based Organic Thin-Film Transistors: A Review of Recent Advances.

PubMed

Melville, Owen A; Lessard, Benoît H; Bender, Timothy P

2015-06-24

Metal phthalocyanines (MPcs) are versatile conjugated macrocycles that have attracted a great deal of interest as active components in modern organic electronic devices. In particular, the charge transport properties of MPcs, their chemical stability, and their synthetic versatility make them ideal candidate materials for use in organic thin-film transistors (OTFTs). This article reviews recent progress in both the material design and device engineering of MPc-based OTFTs, including the introduction of solubilizing groups on the MPcs and the surface modification of substrates to induce favorable MPc self-assembly. Finally, a discussion on emerging niche applications based on MPc OTFTs will be explored, in addition to a perspective and outlook on these promising materials in OTFTs. The scope of this review is focused primarily on the advances made in the field of MPc-based OTFTs since 2008.

Quantum kernel applications in medicinal chemistry.

PubMed

Huang, Lulu; Massa, Lou

2012-07-01

Progress in the quantum mechanics of biological molecules is being driven by computational advances. The notion of quantum kernels can be introduced to simplify the formalism of quantum mechanics, making it especially suitable for parallel computation of very large biological molecules. The essential idea is to mathematically break large biological molecules into smaller kernels that are calculationally tractable, and then to represent the full molecule by a summation over the kernels. The accuracy of the kernel energy method (KEM) is shown by systematic application to a great variety of molecular types found in biology. These include peptides, proteins, DNA and RNA. Examples are given that explore the KEM across a variety of chemical models, and to the outer limits of energy accuracy and molecular size. KEM represents an advance in quantum biology applicable to problems in medicine and drug design.

Effects of salt secretion on psychrometric determinations of water potential of cotton leaves.

PubMed

Klepper, B; Barrs, H D

1968-07-01

Thermocouple psychrometers gave lower estimates of water potential of cotton leaves than did a pressure chamber. This difference was considerable for turgid leaves, but progressively decreased for leaves with lower water potentials and fell to zero at water potentials below about -10 bars. The conductivity of washings from cotton leaves removed from the psychrometric equilibration chambers was related to the magnitude of this discrepancy in water potential, indicating that the discrepancy is due to salts on the leaf surface which make the psychrometric estimates too low. This error, which may be as great as 400 to 500%, cannot be eliminated by washing the leaves because salts may be secreted during the equilibration period. Therefore, a thermocouple psychrometer is not suitable for measuring the water potential of cotton leaves when it is above about -10 bars.

Extraction of Children's Friendship Relation from Activity Level

NASA Astrophysics Data System (ADS)

Kono, Aki; Shintani, Kimio; Katsuki, Takuya; Kihara, Shin'ya; Ueda, Mari; Kaneda, Shigeo; Haga, Hirohide

Children learn to fit into society through living in a group, and it's greatly influenced by their friend relations. Although preschool teachers need to observe them to assist in the growth of children's social progress and support the development each child's personality, only experienced teachers can watch over children while providing high-quality guidance. To resolve the problem, this paper proposes a mathematical and objective method that assists teachers with observation. It uses numerical data of activity level recorded by pedometers, and we make tree diagram called dendrogram based on hierarchical clustering with recorded activity level. Also, we calculate children's ``breadth'' and ``depth'' of friend relations by using more than one dendrogram. When we record children's activity level in a certain kindergarten for two months and evaluated the proposed method, the results usually coincide with remarks of teachers about the children.

Virtual Engine a Tool for Truck Reliability Increase

NASA Astrophysics Data System (ADS)

Stodola, Jiri; Novotny, Pavel

2017-06-01

The internal combustion engine development process requires CAD models which deliver results for the concept phase at a very early stage and which can be further detailed on the same program platform as the development process progresses. The vibratory and acoustic behaviour of the powertrain is highly complex, consisting of many components that are subject to loads that vary greatly in magnitude and which operate at a wide range of speeds. The interaction of the crank and crankcase is a major problem for powertrain designers when optimising the vibration and noise characteristics of the powertrain. The Finite Element Method (FEM) and Multi-Body Systems (MBS) are suitable for the creation of 3-D calculation models. Non-contact measurements make it possible to verify complex calculation models. All numerical simulations and measurements are performed on a Diesel six-cylinder in-line engine.

Contributed review: quantum cascade laser based photoacoustic detection of explosives.

PubMed

Li, J S; Yu, B; Fischer, H; Chen, W; Yalin, A P

2015-03-01

Detecting trace explosives and explosive-related compounds has recently become a topic of utmost importance for increasing public security around the world. A wide variety of detection methods and an even wider range of physical chemistry issues are involved in this very challenging area. Optical sensing methods, in particular mid-infrared spectrometry techniques, have a great potential to become a more desirable tools for the detection of explosives. The small size, simplicity, high output power, long-term reliability make external cavity quantum cascade lasers (EC-QCLs) the promising spectroscopic sources for developing analytical instrumentation. This work reviews the current technical progress in EC-QCL-based photoacoustic spectroscopy for explosives detection. The potential for both close-contact and standoff configurations using this technique is completely presented over the course of approximately the last one decade.

The Obligation to Participate in Biomedical Research

PubMed Central

Schaefer, G. Owen; Emanuel, Ezekiel J.; Wertheimer, Alan

2009-01-01

The prevailing view is that participation in biomedical research is above and beyond the call of duty. While some commentators have offered reasons against this, we propose a novel public goods argument for an obligation to participate in biomedical research. Biomedical knowledge is a public good, available to any individual even if that individual does not contribute to it. Participation in research is a critical way to support that important public good. Consequently, we all have a duty to participate. The current social norm is that people participate only if they have a good reason to do so. The public goods argument implies that people should participate unless they have a good reason not to. Such a shift would be of great aid to the progress of biomedical research, eventually making our society significantly healthier and longer-lived. PMID:19567441

High speed automated microtomography of nuclear emulsions and recent application

NASA Astrophysics Data System (ADS)

Tioukov, V.; Aleksandrov, A.; Consiglio, L.; De Lellis, G.; Vladymyrov, M.

2015-12-01

The development of high-speed automatic scanning systems was the key-factor for massive and successful emulsions application for big neutrino experiments like OPERA. The emulsion detector simplicity, the unprecedented sub-micron spatial resolution and the unique ability to provide intrinsically 3-dimensional spatial information make it a perfect device for short-living particles study, where the event topology should be precisely reconstructed in a 10-100 um scale vertex region. Recently the exceptional technological progress in image processing and automation together with intensive R&D done by Italian and Japanese microscopy groups permit to increase the scanning speed to unbelievable few years ago m2/day scale and so greatly extend the range of the possible applications for emulsion-based detectors to other fields like: medical imaging, directional dark matter search, nuclear physics, geological and industrial applications.

Letter regarding 'Comparison between low-cost marker-less and high-end marker-based motion capture systems for the computer-aided assessment of working ergonomics' by Patrizi et al. and research reproducibility.

PubMed

2017-04-01

The reporting of research in a manner that allows reproduction in subsequent investigations is important for scientific progress. Several details of the recent study by Patrizi et al., 'Comparison between low-cost marker-less and high-end marker-based motion capture systems for the computer-aided assessment of working ergonomics', are absent from the published manuscript and make reproduction of findings impossible. As new and complex technologies with great promise for ergonomics develop, new but surmountable challenges for reporting investigations using these technologies in a reproducible manner arise. Practitioner Summary: As with traditional methods, scientific reporting of new and complex ergonomics technologies should be performed in a manner that allows reproduction in subsequent investigations and supports scientific advancement.

Contributed Review: Quantum cascade laser based photoacoustic detection of explosives

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, J. S., E-mail: jingsong-li@ahu.edu.cn; Yu, B.; Fischer, H.

2015-03-15

Detecting trace explosives and explosive-related compounds has recently become a topic of utmost importance for increasing public security around the world. A wide variety of detection methods and an even wider range of physical chemistry issues are involved in this very challenging area. Optical sensing methods, in particular mid-infrared spectrometry techniques, have a great potential to become a more desirable tools for the detection of explosives. The small size, simplicity, high output power, long-term reliability make external cavity quantum cascade lasers (EC-QCLs) the promising spectroscopic sources for developing analytical instrumentation. This work reviews the current technical progress in EC-QCL-based photoacousticmore » spectroscopy for explosives detection. The potential for both close-contact and standoff configurations using this technique is completely presented over the course of approximately the last one decade.« less

The role of Imaging and Radiation Oncology Core for precision medicine era of clinical trial

PubMed Central

Rosen, Mark

2017-01-01

Imaging and Radiation Oncology Core (IROC) services have been established for the quality assurance (QA) of imaging and radiotherapy (RT) for NCI’s Clinical Trial Network (NCTN) for any trials that contain imaging or RT. The randomized clinical trial is the gold standard for evidence-based medicine. QA ensures data quality, preventing noise from inferior treatments obscuring clinical trial outcome. QA is also found to be cost-effective. IROC has made great progress in multi-institution standardization and is expected to lead QA standardization, QA science in imaging and RT and to advance quality data analysis with big data in the future. The QA in the era of precision medicine is of paramount importance, when individualized decision making may depend on the quality and accuracy of RT and imaging. PMID:29218265

Open Source 2010: Reflections on 2007

ERIC Educational Resources Information Center

Wheeler, Brad

2007-01-01

Colleges and universities and commercial firms have demonstrated great progress in realizing the vision proffered for "Open Source 2007," and 2010 will mark even greater progress. Although much work remains in refining open source for higher education applications, the signals are now clear: the collaborative development of software can provide…

Energy and wood from intensively cultured plantations: research and development program.

Treesearch

USDA FS

1980-01-01

Since 1971 there has been significant progress in greatly increasing yields of wood and energy (biomass) from intensively cultured plantations compared with natural stands. This publication reports the results of studies and summarizes the "maximum-yield" research in progress at the North Central Forest Experiment Station.

Evaluating Youth Development Programs: Progress and Promise

ERIC Educational Resources Information Center

Roth, Jodie L.; Brooks-Gunn, Jeanne

2016-01-01

Advances in theories of adolescent development and positive youth development have greatly increased our understanding of how programs and practices with adolescents can impede or enhance their development. In this article the authors reflect on the progress in research on youth development programs in the last two decades, since possibly the…

Struggle for the Soul of Felix Adler

ERIC Educational Resources Information Center

Stallones, Jared R.

2009-01-01

A number of authors have drawn connections between progressive education and the Social Gospel movement, the Second Great Awakening, and other phenomena of 19th century America. In most cases these authors have focused on progressive educators from Protestant backgrounds, but progressivism reached into other American subcultures. Felix Adler was…

Nuclear Data Covariances in the Indian Context – Progress, Challenges, Excitement and Perspectives

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ganesan, S., E-mail: gane-san555@gmail.com

We present a brief overview of progress, challenges, excitement and perspectives in developing nuclear data covariances in the Indian context in relation to target accuracies and sensitivity studies that are of great importance to Bhabha's 3-stage nuclear programme for energy and non-energy applications.

Architecture is Elementary: Visual Thinking through Architectural Concepts.

ERIC Educational Resources Information Center

Winters, Nathan B.

This book presents very basic but important concepts about architecture and outlines some of the most important concepts used by great architects. These concepts are taught at levels of perceptual maturity applicable to adults and children alike and progress from levels one through seven as the concepts become progressively intertwined. The…

75 FR 8728 - Great Lakes Pilotage Advisory Committee

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-25

... DEPARTMENT OF HOMELAND SECURITY Coast Guard [USCG-2010-0125] Great Lakes Pilotage Advisory Committee AGENCY: Coast Guard, DHS. ACTION: Notice of meeting. SUMMARY: The Great Lakes Pilotage Advisory... makes recommendations to the Secretary on a wide range of issues related to pilotage on the Great Lakes...

Making a Great First Impression

ERIC Educational Resources Information Center

Evenson, Renee

2007-01-01

Managers and business owners often base hiring decisions on first impressions. That is why it is so important to teach students to make a great first impression--before they go on that first job interview. Managers do not have unrealistic expectations, they just want to hire people who they believe can develop into valuable employees. A nice…

Developing an Initial Learning Progression for the Use of Evidence in Decision-Making Contexts

ERIC Educational Resources Information Center

Bravo-Torija, Beatriz; Jiménez-Aleixandre, María-Pilar

2018-01-01

This paper outlines an initial learning progression for the use of evidence to support scientific arguments in the context of decision-making. Use of evidence is a central feature of knowledge evaluation and, therefore, of argumentation. The proposal is based on the literature on argumentation and use of evidence in decision-making contexts. The…

Great Basin Native Plant Project: 2014 Progress Report

Treesearch

Francis Kilkenny; Anne Halford; Alexis Malcomb

2015-01-01

The Interagency Native Plant Materials Development Program outlined in the 2002 United States Department of Agriculture (USDA) and United States Department of Interior (USDI) Report to Congress encouraged use of native plant materials for rangeland rehabilitation and restoration where feasible. The Great Basin Native Plant Project is a cooperative project lead by the...

Great Basin Native Plant Project: 2013 Progress Report

Treesearch

Francis Kilkenny; Nancy Shaw; Corey Gucker

2014-01-01

The Interagency Native Plant Materials Development Program outlined in the 2002 United States Department of Agriculture (USDA) and United States Department of Interior (USDI) Report to Congress encouraged use of native plant materials for rangeland rehabilitation and restoration where feasible. The Great Basin Native Plant Project is a cooperative project lead by the...

Registered nurses' decision-making regarding documentation in patients' progress notes.

PubMed

Tower, Marion; Chaboyer, Wendy; Green, Quentine; Dyer, Kirsten; Wallis, Marianne

2012-10-01

To examine registered nurses' decision-making when documenting care in patients' progress notes. What constitutes effective nursing documentation is supported by available guidelines. However, ineffective documentation continues to be cited as a major cause of adverse events for patients. Decision-making in clinical practice is a complex process. To make an effective decision, the decision-maker must be situationally aware. The concept of situation awareness and its implications for making safe decisions has been examined extensively in air safety and more recently is being applied to health. The study was situated in a naturalistic paradigm. Purposive sampling was used to recruit 17 registered nurses who used think-aloud research methods when making decisions about documenting information in patients' progress notes. Follow-up interviews were conducted to validate interpretations. Data were analysed systematically for evidence of cues that demonstrated situation awareness as nurses made decisions about documentation. Three distinct decision-making scenarios were illuminated from the analysis: the newly admitted patient, the patient whose condition was as expected and the discharging patient. Nurses used mental models for decision-making in documenting in progress notes, and the cues nurses used to direct their assessment of patients' needs demonstrated situation awareness at different levels. Nurses demonstrate situation awareness at different levels in their decision-making processes. While situation awareness is important, it is also important to use an appropriate decision-making framework. Cognitive continuum theory is suggested as a decision-making model that could support situation awareness when nurses made decisions about documenting patient care. Because nurses are key decision-makers, it is imperative that effective decisions are made that translate into safe clinical care. Including situation awareness training, combined with employing cognitive continuum theory as a decision-making framework, provides a powerful means of guiding nurses' decision-making. © 2012 Blackwell Publishing Ltd.

Burrowing mayflies (Hexagenia) as indicators of ecosystem health

USGS Publications Warehouse

Edsall, Thomas A.

2001-01-01

Three State of the Lakes Ecosystem Conferences have been held since 1996 to encourage the development of Great Lakes indicators of ecosystem health for use in reporting on progress in restoring and maintaining the chemical, physical and biological integrity of the Great Lakes ecosystem. Here we report on the development of an indicator based on burrowing mayflies , Hexagenia (Ephemeroptera: Ephemeridae), using production and biomass as the indicator metrics. Burrowing mayflies were selected because they (1) were historically abundant in unpolluted, soft-bottomed mesotrophic habitats throughout the Great Lakes, (2) are intolerant of and were extirpated by pollution in most of those habitats during the 1940s to1950s, (3) have shown the ability to recover in one of those habitats following pollution abatement, (4) are ecologically important as bioturbators of lakebed sediments and as trophic integrators that link detrital energy resources directly to fishes that feed preferentially on them, and (5) have highly visible mating flights, which carry the message directly to an informed public that the source water body is healthy. In addition, their annual production can be estimated from their mean annual biomass by the sizefrequency method. Productivity and biomass can also could be estimated with a 'cohort-direct' method, using the biomass of mature nymphs collected in May or early June from the cohort that is about to emerge as subimagos in late June or early July. Although both the size-frequency and cohort-direct methods provide reliable estimates of productivity and biomass, the latter method greatly reduces sample collection and processing effort and thus makes it feasible to use Hexagenia as an indicator of ecosystem health in surveys requiring the collection of large numbers of samples.

PSI-Center Final Progress Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jarboe, Thomas R.; Shumlak, Uri; Sovinec, Carl

This is the Final Progress Report of the Plasma Science and Innovation Center (PSI-Center) covering March 2014 through February 2017. The Center has accomplished a great deal during this period. The PSI-Center is organized into four groups: Edge and Dynamic Neutrals; Transport and Kinetic Effects; Equilibrium, Stability, and Kinetic Effects in 3D Topologies; and Interface for Validation. Each group has made good progress and the results from each group are given in detail.

48 CFR 52.232-16 - Progress Payments.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 2 2011-10-01 2011-10-01 false Progress Payments. 52.232... Progress Payments. As prescribed in 32.502-4(a), insert the following clause: Progress Payments (AUG 2010) The Government will make progress payments to the Contractor when requested as work progresses, but...

25 CFR 30.123 - What is the Bureau's role in assisting Bureau-funded schools to make AYP?

Code of Federal Regulations, 2010 CFR

2010-04-01

... EDUCATION ADEQUATE YEARLY PROGRESS Failure To Make Adequate Yearly Progress § 30.123 What is the Bureau's...-funded schools to assist them in achieving AYP. This includes technical assistance and other forms of...

25 CFR 30.123 - What is the Bureau's role in assisting Bureau-funded schools to make AYP?

Code of Federal Regulations, 2011 CFR

2011-04-01

... EDUCATION ADEQUATE YEARLY PROGRESS Failure To Make Adequate Yearly Progress § 30.123 What is the Bureau's...-funded schools to assist them in achieving AYP. This includes technical assistance and other forms of...

Genomic tools to improve progress and preserve variation for future generations

USDA-ARS?s Scientific Manuscript database

Use of genomic tools has greatly decreased generation intervals and increased genetic progress in dairy cattle, but faster selection cycles can also increase rates of inbreeding per unit of time. Average pedigree inbreeding of Holstein cows increased from 4.6% in 2000 to 5.6% in 2009 to 6.6% in 201...

Paradox in Progressive Educational Reform: The South and the Education of Blacks in the Depression Years

ERIC Educational Resources Information Center

Goodenow, Ronald K.

1978-01-01

Progressive educational reform in the South during the Great Depression is examined. Ways in which educational change seemingly functioned to serve modernization while concurrently maintaining racist patterns are illustrated. It is suggested that fundamental change in the conditions of oppression may not be possible without addressing the…

Book Probes Scoring Gaps Tied to Race

ERIC Educational Resources Information Center

Viadero, Debra

2009-01-01

A recent book assembles a collection of studies on one of the great mysteries of contemporary American education: Why did national progress in narrowing the achievement gap separating African-American and white students stall from the late 1980s until 2004? "Steady Gains and Stalled Progress," published by the Russell Sage Foundation of New York…

Accumulation of evidence during sequential decision making: the importance of top-down factors.

PubMed

de Lange, Floris P; Jensen, Ole; Dehaene, Stanislas

2010-01-13

In the last decade, great progress has been made in characterizing the accumulation of neural information during simple unitary perceptual decisions. However, much less is known about how sequentially presented evidence is integrated over time for successful decision making. The aim of this study was to study the mechanisms of sequential decision making in humans. In a magnetoencephalography (MEG) study, we presented healthy volunteers with sequences of centrally presented arrows. Sequence length varied between one and five arrows, and the accumulated directions of the arrows informed the subject about which hand to use for a button press at the end of the sequence (e.g., LRLRR should result in a right-hand press). Mathematical modeling suggested that nonlinear accumulation was the rational strategy for performing this task in the presence of no or little noise, whereas quasilinear accumulation was optimal in the presence of substantial noise. MEG recordings showed a correlate of evidence integration over parietal and central cortex that was inversely related to the amount of accumulated evidence (i.e., when more evidence was accumulated, neural activity for new stimuli was attenuated). This modulation of activity likely reflects a top-down influence on sensory processing, effectively constraining the influence of sensory information on the decision variable over time. The results indicate that, when making decisions on the basis of sequential information, the human nervous system integrates evidence in a nonlinear manner, using the amount of previously accumulated information to constrain the accumulation of additional evidence.

Great Basin Native Plant Selection and Increase Project: FY2010 Progress Report

Treesearch

Nancy Shaw; Mike Pellant

2011-01-01

The Interagency Native Plant Materials Development Program outlined in the 2002 Report to Congress (USDI and USDA 2002), USDI Bureau of Land Management programs and policies, and the Great Basin Restoration Initiative encourage the use of native species for rangeland rehabilitation and restoration where feasible. This project was initiated to foster the development of...

Great Basin Native Plant Selection and Increase Project FY08 Progress Report

Treesearch

Nancy Shaw; Mike Pellant

2009-01-01

The Interagency Native Plant Materials Development Program (USDI and USDA 2002), USDI Bureau of Land Management programs and policies, and the Great Basin Restoration Initiative encourage the use of native species for rangeland rehabilitation and restoration where feasible. This project was initiated to foster the development of native plant materials for use in the...

Great Basin Native Plant Selection and Increase Project: 2011 Progress Report

Treesearch

Nancy Shaw; Mike Pellant

2012-01-01

The Interagency native Plant Materials Development Program outlined in the 2002 Report to Congress (USDI and USDA 2002), USDI Bureau of Land Management programs and policies, and the Great Basin Restoration Initiative encourage the use of native species for rangeland rehabilitation and restoration where feasible. This project was initiated to foster the development of...

Development of a benthic invertebrate objective for mesotrophic Great Lakes waters

USGS Publications Warehouse

Reynoldson, Trefor B.; Schloesser, Donald W.; Manny, Bruce A.

1989-01-01

A biological indicator of mesotrophic conditions should (1) provide an appropriate and interpretable objective; (2) be achievable if corrective measures are taken (i.e., it should be within the expected environmental range of the system); and (3) allow measurement of progress toward the objective. Historical data from the Great Lakes suggest that population density of the burrowing mayfly, Hexagenia limbata, could provide an appropriate objective, and that the tubificid oligochaete community can be used to evaluate progress toward that objective. Finally, data from other systems show thatHexagenia can return to locations where it was formerly abundant, and therefore is an attainable objective for formerly mesotrophic ecosystems.

WFIRST-AFTA Presentation to the NRC Mid-Decadal Panel

NASA Technical Reports Server (NTRS)

Gehrels, Neil; Grady, Kevin; Ruffa, John; Melton, Mark; Content, Dave; Zhao, Feng

2015-01-01

Over the past two years, increased funding has enabled significant progress in technology matura1on as well as addi1onal fidelity in the design reference mission. WFIRST with the 2.4-­-m telescope and coronagraph provides an exci1ng science program, superior to that recommended by NWNH and also advances exoplanet imaging technology (the highest ranked medium-­-class NWNH recommenda1on). Great opportunity for astronomy and astrophysics discoveries. Broad community support for WFIRST. Key development areas are anchored in a decade of investments in JPL's HCIT and GSFC's DCL. Great progress made in pre-­-formula1on, ready for KDP-­-A and launch in mid-­-2020s.

Fostering Synergies Among Organizations to put Climate in Context for Use in Decision Making

NASA Astrophysics Data System (ADS)

Garfin, G. M.; Parris, A.; Dow, K.; Meyer, R.; Close, S.

2016-12-01

Making science usable for decision making requires a knowledge of the social and institutional contexts of decision making, an ability to develop or tap into networks for sharing information and developing knowledge, a capacity for innovating or providing services, and a program for social learning to inform decisions and improve the processes of engagement and collaboration (i.e., mechanisms for feedback, evaluation, and changes in policy or practices). Active participation by and partnerships between researchers, practitioners, and decision-makers provides a foundation for making progress in each of the aforementioned areas of endeavor. In twenty years of incubating experimental climate services, the NOAA Regional Integrated Sciences and Assessments program offers not a few ideas and examples of practices to foster synergies among organizations, that result in tangible benefits to decision-makers. Strategies include (a) designing explicit mutual learning through temporary institutions, such as workshop series, in order to develop social capital and knowledge networks (e.g., to co-develop and disseminate experimental forecasts); (b) articulating ground rules, roles, and responsibilities in managing the boundary between scientists and practitioners (e.g., in multi-partner climate adaptation planning processes); and (c) cross-training between scientists and practitioners, by embedding team members in other organizations or recruiting members from those organizations (e.g., Cooperative Extension). A promising strategy is boundary chaining, pioneered by the Great Lakes Integrated Sciences and Assessments, in which science information and service providers partner with other boundary organizations, to leverage networks, expertise, resources, and to reduce transaction costs. Partners with complementary strengths and roles can then, work iteratively and synergize to mediate the co-production of a combination of services for decision making, such as data and information, facilitation, and evaluation.

The Value of Understanding Indigenous Thinking in the Geosciences: The Understudied Genius of Hawaiian Schoolchildren

NASA Astrophysics Data System (ADS)

Slater, S. J.; Dye, A.; Veincent, L.; Slater, T. F.; CenterAstronomy; Physics Education Research

2011-12-01

The national effort to describe the "learning progressions" that students undertake as they come to master the Big Ideas of science has evolved into a machine that is making a great deal of motion, but that may not actually be taking us into new territory. The original vision of thoughtful, long-term collaborations between scientists, anthropologists, linguists, and other who could shed new light on students' science learning has been replaced by a research agenda that sounds rigorous, but may or may not provide new insight. Moreover, there is little evidence that the learning pathways of under-represented populations are being taken into account in this work, even though these are the very students that were intended to benefit from potential learning progression-driven curricular changes. Our observations of a sample of Native Hawaiian elementary school children indicate that their particular scientific strengths provide sufficient cause to slow the engines of the learning progressions movement to allow for careful research into the thinking of underrepresented populations. This paper presents preliminary results of our mixed methods analysis of interviews and artifacts related to K-2 students' understanding of the celestial sphere. Our findings indicate that contrary to all previous research and rationale tasks analyses, these students possess full mastery of the constellations, starlines, right ascension and declination within the celestial sphere, and can generatively use this knowledge. This knowledge is flexible to include two culture's starmaps and languages. This study suggests that in order to respond to the needs of underrepresented minorities, further research across indigenous populations is warranted prior to the nationalization of learning progression-based curriculum materials.

An Integrated Approach to Parameter Learning in Infinite-Dimensional Space

DOE Office of Scientific and Technical Information (OSTI.GOV)

Boyd, Zachary M.; Wendelberger, Joanne Roth

The availability of sophisticated modern physics codes has greatly extended the ability of domain scientists to understand the processes underlying their observations of complicated processes, but it has also introduced the curse of dimensionality via the many user-set parameters available to tune. Many of these parameters are naturally expressed as functional data, such as initial temperature distributions, equations of state, and controls. Thus, when attempting to find parameters that match observed data, being able to navigate parameter-space becomes highly non-trivial, especially considering that accurate simulations can be expensive both in terms of time and money. Existing solutions include batch-parallel simulations,more » high-dimensional, derivative-free optimization, and expert guessing, all of which make some contribution to solving the problem but do not completely resolve the issue. In this work, we explore the possibility of coupling together all three of the techniques just described by designing user-guided, batch-parallel optimization schemes. Our motivating example is a neutron diffusion partial differential equation where the time-varying multiplication factor serves as the unknown control parameter to be learned. We find that a simple, batch-parallelizable, random-walk scheme is able to make some progress on the problem but does not by itself produce satisfactory results. After reducing the dimensionality of the problem using functional principal component analysis (fPCA), we are able to track the progress of the solver in a visually simple way as well as viewing the associated principle components. This allows a human to make reasonable guesses about which points in the state space the random walker should try next. Thus, by combining the random walker's ability to find descent directions with the human's understanding of the underlying physics, it is possible to use expensive simulations more efficiently and more quickly arrive at the desired parameter set.« less

Making America's Schools Great Now: Reclaiming Democracy and Activist Leadership under Trump

ERIC Educational Resources Information Center

Horsford, Sonya Douglass

2018-01-01

Trump's vow to "make America great again" seeks to usher in a policy agenda reminiscent of an era that served as a boon to the rich while devastating poor, working-class, Americans, particularly people of color. His education policy and budget blueprint prove no exception, signalling troubling priorities for those who value strong public…

Building the Capacity of Principals and Teacher-Leaders to Implement Effective School and Classroom Practices.

ERIC Educational Resources Information Center

Southern Regional Education Board (SREB), 2012

2012-01-01

Great leaders make great schools. The most successful school leaders create a school climate of high achievement and continuous improvement, give teachers a voice in decision-making, use data to drive curriculum and instruction, and assure students and parents that everyone at the school is focusing on student success. They know what is going on…

A hybrid organic-inorganic perovskite dataset

NASA Astrophysics Data System (ADS)

Kim, Chiho; Huan, Tran Doan; Krishnan, Sridevi; Ramprasad, Rampi

2017-05-01

Hybrid organic-inorganic perovskites (HOIPs) have been attracting a great deal of attention due to their versatility of electronic properties and fabrication methods. We prepare a dataset of 1,346 HOIPs, which features 16 organic cations, 3 group-IV cations and 4 halide anions. Using a combination of an atomic structure search method and density functional theory calculations, the optimized structures, the bandgap, the dielectric constant, and the relative energies of the HOIPs are uniformly prepared and validated by comparing with relevant experimental and/or theoretical data. We make the dataset available at Dryad Digital Repository, NoMaD Repository, and Khazana Repository (http://khazana.uconn.edu/), hoping that it could be useful for future data-mining efforts that can explore possible structure-property relationships and phenomenological models. Progressive extension of the dataset is expected as new organic cations become appropriate within the HOIP framework, and as additional properties are calculated for the new compounds found.

Sub-5 nm, globally aligned graphene nanoribbons on Ge(001)

DOE PAGES

Kiraly, Brian; Mannix, Andrew J.; Jacobberger, Robert M.; ...

2016-05-23

Graphene nanoribbons (GNRs) hold great promise for future electronics because of their edge and width dependent electronic bandgaps and exceptional transport properties. While significant progress toward such devices has been made, the field has been limited by difficulties achieving narrow widths, global alignment, and atomically pristine GNR edges on technologically relevant substrates. A recent advance has challenged these limits by using Ge(001) substrates to direct the bottom-up growth of GNRs with nearly pristine armchair edges and widths near ~10 nm via atmospheric pressure chemical vapor deposition. In this work, we extend the growth of GNRs on Ge(001) to ultra-high vacuummore » conditions and realize GNRs narrower than 5 nm. Armchair graphene nanoribbons directed along the Ge <110> surface directions are achieved with excellent width control and relatively large bandgaps. As a result, the bandgap magnitude and electronic uniformity make these new materials excellent candidates for future developments in nanoelectronics.« less

High speed automated microtomography of nuclear emulsions and recent application

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tioukov, V.; Aleksandrov, A.; Consiglio, L.

2015-12-31

The development of high-speed automatic scanning systems was the key-factor for massive and successful emulsions application for big neutrino experiments like OPERA. The emulsion detector simplicity, the unprecedented sub-micron spatial resolution and the unique ability to provide intrinsically 3-dimensional spatial information make it a perfect device for short-living particles study, where the event topology should be precisely reconstructed in a 10-100 um scale vertex region. Recently the exceptional technological progress in image processing and automation together with intensive R&D done by Italian and Japanese microscopy groups permit to increase the scanning speed to unbelievable few years ago m{sup 2}/day scalemore » and so greatly extend the range of the possible applications for emulsion-based detectors to other fields like: medical imaging, directional dark matter search, nuclear physics, geological and industrial applications.« less

Parametric study of variation in cargo-airplane performance related to progression from current to spanloader designs

NASA Technical Reports Server (NTRS)

Toll, T. A.

1980-01-01

A parametric analysis was made to investigate the relationship between current cargo airplanes and possible future designs that may differ greatly in both size and configuration. The method makes use of empirical scaling laws developed from statistical studies of data from current and advanced airplanes and, in addition, accounts for payload density, effects of span distributed load, and variations in tail area ratio. The method is believed to be particularly useful for exploratory studies of design and technology options for large airplanes. The analysis predicts somewhat more favorable variations of the ratios of payload to gross weight and block fuel to payload as the airplane size is increased than has been generally understood from interpretations of the cube-square law. In terms of these same ratios, large all wing (spanloader) designs show an advantage over wing-fuselage designs.

Neurofibromatoses: part 1 - diagnosis and differential diagnosis.

PubMed

Rodrigues, Luiz Oswaldo Carneiro; Batista, Pollyanna Barros; Goloni-Bertollo, Eny Maria; de Souza-Costa, Danielle; Eliam, Lucas; Eliam, Miguel; Cunha, Karin Soares Gonçalves; Darrigo-Junior, Luiz Guilherme; Ferraz-Filho, José Roberto Lopes; Geller, Mauro; Gianordoli-Nascimento, Ingrid F; Madeira, Luciana Gonçalves; Malloy-Diniz, Leandro Fernandes; Mendes, Hérika Martins; de Miranda, Débora Marques; Pavarino, Erika Cristina; Baptista-Pereira, Luciana; Rezende, Nilton A; Rodrigues, Luíza de Oliveira; da Silva, Carla Menezes; de Souza, Juliana Ferreira; de Souza, Márcio Leandro Ribeiro; Stangherlin, Aline; Valadares, Eugênia Ribeiro; Vidigal, Paula Vieira Teixeira

2014-03-01

Neurofibromatoses (NF) are a group of genetic multiple tumor growing predisposition diseases: neurofibromatosis type 1 (NF1), neurofibromatosis type 2 (NF2) and schwannomatosis (SCH), which have in common the neural origin of tumors and cutaneous signs. They affect nearly 80 thousand of Brazilians. In recent years, the increased scientific knowledge on NF has allowed better clinical management and reduced complication morbidity, resulting in higher quality of life for NF patients. In most cases, neurology, psychiatry, dermatology, clinical geneticists, oncology and internal medicine specialists are able to make the differential diagnosis between NF and other diseases and to identify major NF complications. Nevertheless, due to its great variability in phenotype expression, progressive course, multiple organs involvement and unpredictable natural evolution, NF often requires the support of neurofibromatoses specialists for proper treatment and genetic counseling. This Part 1 offers step-by-step guidelines for NF differential diagnosis. Part 2 will present the NF clinical management.

Recent advances in applications of nanomaterials for sample preparation.

PubMed

Xu, Linnan; Qi, Xiaoyue; Li, Xianjiang; Bai, Yu; Liu, Huwei

2016-01-01

Sample preparation is a key step for qualitative and quantitative analysis of trace analytes in complicated matrix. Along with the rapid development of nanotechnology in material science, numerous nanomaterials have been developed with particularly useful applications in analytical chemistry. Benefitting from their high specific areas, increased surface activities, and unprecedented physical/chemical properties, the potentials of nanomaterials for rapid and efficient sample preparation have been exploited extensively. In this review, recent progress of novel nanomaterials applied in sample preparation has been summarized and discussed. Both nanoparticles and nanoporous materials are evaluated for their unusual performance in sample preparation. Various compositions and functionalizations extended the applications of nanomaterials in sample preparations, and distinct size and shape selectivity was generated from the diversified pore structures of nanoporous materials. Such great variety make nanomaterials a kind of versatile tools in sample preparation for almost all categories of analytes. Copyright © 2015 Elsevier B.V. All rights reserved.

Itaipu: never underestimate the Latins. [Paraguay/Brazil binational project] (in English and Spanish)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1983-04-06

The Itaipu hydroelectric project, a joint effort of Brazil and Paraguay (with a cost of US $16 to 18 billion), will be finished in December 1989. The project is situated on the Parana River, 14 km beyond the Puente de da Amistad (Friendship Bridge), which connects the city Presidente Stroessner, in Paraguay, with Foz do Iguacu, in Brazil. It is considered today not only the biggest hydroelectric plant in the world, but also a great socio-economic boom in the making. Itaipu will add a total of 12.6-million kilowatt-hours (kWh) of hydroelectricity to the region, an equivalent of 600,000 barrels ofmore » oil daily (b/d). This issue of Energy Detente reviews the progress of Itaipu. Also appearing in this issue is the fuel price/tax series and the principal industrial fuel prices for April 1983 for countries of the Eastern Hemisphere.« less

The 1999 Crafoord Prize lectures. Neo-Lamarckian experimentalism in America: origins and consequences.

PubMed

Cook, G M

1999-12-01

The 1890s and the first decades of the twentieth century saw a vigorous debate about the mechanisms of evolutionary change. On one side, August Weismann defended the selectionist hypothesis; on the other, Herbert Spencer defended neo-Lamarckian theory. Supporters of Spencer, notably the American paleontologist and evolutionary theorist Henry Fairfield Osborn, recognized that the questions raised by Weismann and Spencer could only be settled experimentally. They called for the application of experimental methods, and the establishment of a new institution for the purpose of confirming the inheritance of acquired characters. To a great extent, the experimental program championed by Osborn and others was implemented and, although it failed to reveal soft inheritance and was soon eclipsed by Mendelian and chromosomal genetics, it did make significant and lasting contributions to evolutionary biology. Thus the importance of methodological and institutional innovation and theoretical pluralism to the progress of science is illustrated and underscored.

Hydrophobic Organic Hole Transporters for Improved Moisture Resistance in Metal Halide Perovskite Solar Cells.

PubMed

Leijtens, Tomas; Giovenzana, Tommaso; Habisreutinger, Severin N; Tinkham, Jonathan S; Noel, Nakita K; Kamino, Brett A; Sadoughi, Golnaz; Sellinger, Alan; Snaith, Henry J

2016-03-09

Solar cells based on organic-inorganic perovskite semiconductor materials have recently made rapid improvements in performance, with the best cells performing at over 20% efficiency. With such rapid progress, questions such as cost and solar cell stability are becoming increasingly important to address if this new technology is to reach commercial deployment. The moisture sensitivity of commonly used organic-inorganic metal halide perovskites has especially raised concerns. Here, we demonstrate that the hygroscopic lithium salt commonly used as a dopant for the hole transport material in perovskite solar cells makes the top layer of the devices hydrophilic and causes the solar cells to rapidly degrade in the presence of moisture. By using novel, low cost, and hydrophobic hole transporters in conjunction with a doping method incorporating a preoxidized salt of the respective hole transporters, we are able to prepare efficient perovskite solar cells with greatly enhanced water resistance.

Effects of Salt Secretion on Psychrometric Determinations of Water Potential of Cotton Leaves

PubMed Central

Klepper, Betty; Barrs, H. D.

1968-01-01

Thermocouple psychrometers gave lower estimates of water potential of cotton leaves than did a pressure chamber. This difference was considerable for turgid leaves, but progressively decreased for leaves with lower water potentials and fell to zero at water potentials below about −10 bars. The conductivity of washings from cotton leaves removed from the psychrometric equilibration chambers was related to the magnitude of this discrepancy in water potential, indicating that the discrepancy is due to salts on the leaf surface which make the psychrometric estimates too low. This error, which may be as great as 400 to 500%, cannot be eliminated by washing the leaves because salts may be secreted during the equilibration period. Therefore, a thermocouple psychrometer is not suitable for measuring the water potential of cotton leaves when it is above about −10 bars. PMID:16656895

Perovskite Solar Cells: From the Atomic Level to Film Quality and Device Performance.

PubMed

Saliba, Michael; Correa-Baena, Juan-Pablo; Grätzel, Michael; Hagfeldt, Anders; Abate, Antonio

2018-03-01

Organic-inorganic perovskites have made tremendous progress in recent years due to exceptional material properties such as high panchromatic absorption, charge carrier diffusion lengths, and a sharp optical band edge. The combination of high-quality semiconductor performance with low-cost deposition techniques seems to be a match made in heaven, creating great excitement far beyond academic ivory towers. This is particularly true for perovskite solar cells (PSCs) that have shown unprecedented gains in efficiency and stability over a time span of just five years. Now there are serious efforts for commercialization with the hope that PSCs can make a major impact in generating inexpensive, sustainable solar electricity. In this Review, we will focus on perovskite material properties as well as on devices from the atomic to the thin film level to highlight the remaining challenges and to anticipate the future developments of PSCs. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Recent progress in GeSn growth and GeSn-based photonic devices

NASA Astrophysics Data System (ADS)

Zheng, Jun; Liu, Zhi; Xue, Chunlai; Li, Chuanbo; Zuo, Yuhua; Cheng, Buwen; Wang, Qiming

2018-06-01

The GeSn binary alloy is a new group IV material that exhibits a direct bandgap when the Sn content exceeds 6%. It shows great potential for laser use in optoelectronic integration circuits (OEIC) on account of its low light emission efficiency arising from the indirect bandgap characteristics of Si and Ge. The bandgap of GeSn can be tuned from 0.6 to 0 eV by varying the Sn content, thus making this alloy suitable for use in near-infrared and mid-infrared detectors. In this paper, the growth of the GeSn alloy is first reviewed. Subsequently, GeSn photodetectors, light emitting diodes, and lasers are discussed. The GeSn alloy presents a promising pathway for the monolithic integration of Si photonic circuits by the complementary metal–oxide–semiconductor (CMOS) technology. Project supported by the Beijing Natural Science Foundation (No. 4162063) and the Youth Innovation Promotion Association of CAS (No. 2015091).

Agrigenomics for microalgal biofuel production: an overview of various bioinformatics resources and recent studies to link OMICS to bioenergy and bioeconomy.

PubMed

Misra, Namrata; Panda, Prasanna Kumar; Parida, Bikram Kumar

2013-11-01

Microalgal biofuels offer great promise in contributing to the growing global demand for alternative sources of renewable energy. However, to make algae-based fuels cost competitive with petroleum, lipid production capabilities of microalgae need to improve substantially. Recent progress in algal genomics, in conjunction with other "omic" approaches, has accelerated the ability to identify metabolic pathways and genes that are potential targets in the development of genetically engineered microalgal strains with optimum lipid content. In this review, we summarize the current bioeconomic status of global biofuel feedstocks with particular reference to the role of "omics" in optimizing sustainable biofuel production. We also provide an overview of the various databases and bioinformatics resources available to gain a more complete understanding of lipid metabolism across algal species, along with the recent contributions of "omic" approaches in the metabolic pathway studies for microalgal biofuel production.

High granularity tracker based on a Triple-GEM optically read by a CMOS-based camera

NASA Astrophysics Data System (ADS)

Marafini, M.; Patera, V.; Pinci, D.; Sarti, A.; Sciubba, A.; Spiriti, E.

2015-12-01

The detection of photons produced during the avalanche development in gas chambers has been the subject of detailed studies in the past. The great progresses achieved in last years in the performance of micro-pattern gas detectors on one side and of photo-sensors on the other provide the possibility of making high granularity and very sensitive particle trackers. In this paper, the results obtained with a triple-GEM structure read-out by a CMOS based sensor are described. The use of an He/CF4 (60/40) gas mixture and a detailed optimization of the electric fields made possible to obtain a very high GEM light yield. About 80 photons per primary electron were detected by the sensor resulting in a very good capability of tracking both muons from cosmic rays and electrons from natural radioactivity.

Integrating Deoxyribozymes into Colorimetric Sensing Platforms

PubMed Central

Chang, Dingran; Zakaria, Sandy; Deng, Mimi; Allen, Nicholas; Tram, Kha; Li, Yingfu

2016-01-01

Biosensors are analytical devices that have found a variety of applications in medical diagnostics, food quality control, environmental monitoring and biodefense. In recent years, functional nucleic acids, such as aptamers and nucleic acid enzymes, have shown great potential in biosensor development due to their excellent ability in target recognition and catalysis. Deoxyribozymes (or DNAzymes) are single-stranded DNA molecules with catalytic activity and can be isolated to recognize a wide range of analytes through the process of in vitro selection. By using various signal transduction mechanisms, DNAzymes can be engineered into fluorescent, colorimetric, electrochemical and chemiluminescent biosensors. Among them, colorimetric sensors represent an attractive option as the signal can be easily detected by the naked eye. This reduces reliance on complex and expensive equipment. In this review, we will discuss the recent progress in the development of colorimetric biosensors that make use of DNAzymes and the prospect of employing these sensors in a range of chemical and biological applications. PMID:27918487

Predicting adverse hemodynamic events in critically ill patients.

PubMed

Yoon, Joo H; Pinsky, Michael R

2018-06-01

The art of predicting future hemodynamic instability in the critically ill has rapidly become a science with the advent of advanced analytical processed based on computer-driven machine learning techniques. How these methods have progressed beyond severity scoring systems to interface with decision-support is summarized. Data mining of large multidimensional clinical time-series databases using a variety of machine learning tools has led to our ability to identify alert artifact and filter it from bedside alarms, display real-time risk stratification at the bedside to aid in clinical decision-making and predict the subsequent development of cardiorespiratory insufficiency hours before these events occur. This fast evolving filed is primarily limited by linkage of high-quality granular to physiologic rationale across heterogeneous clinical care domains. Using advanced analytic tools to glean knowledge from clinical data streams is rapidly becoming a reality whose clinical impact potential is great.

[Smart drug delivery systems based on nanoscale ZnO].

PubMed

Huang, Xiao; Chen, Chun; Yi, Caixia; Zheng, Xi

2018-04-01

In view of the excellent biocompatibility as well as the low cost, nanoscale ZnO shows great potential for drug delivery application. Moreover, The charming character enable nanoscale ZnO some excellent features (e.g. dissolution in acid, ultrasonic permeability, microwave absorbing, hydrophobic/hydrophilic transition). All of that make nanoscale ZnO reasonable choices for smart drug delivery. In the recent decade, more and more studies have focused on controlling the drug release behavior via smart drug delivery systems based on nanoscale ZnO responsive to some certain stimuli. Herein, we review the recent exciting progress on the pH-responsive, ultrasound-responsive, microwave-responsive and UV-responsive nanoscale ZnO-based drug delivery systems. A brief introduction of the drug controlled release behavior and its effect of the drug delivery systems is presented. The biocompatibility of nanoscale ZnO is also discussed. Moreover, its development prospect is looked forward.

Toward a New Outlook on Primate Learning and Behavior: Complex Learning and Emergent Processes in Comparative Perspective

NASA Technical Reports Server (NTRS)

Rumbaugh, Duane M.; Savage-Rumbaugh, E. Sue; Washburn, David A.

1996-01-01

Primate research of the 20th century has established the validity of Darwin's postulation of psychological as well as biological continuity between humans and other primates, notably the great apes. Its data make clear that Descartes' view of animals as unfeeling 'beast-machines' is invalid and should be discarded. Traditional behavioristic frameworks, that emphasize the concepts of stimulus, response, and reinforcement and an 'empty-organism' psychology, are in need of major revisions. Revised frameworks should incorporate the fact that, in contrast to the lifeless databases of the 'hard' sciences, the database of psychology entails properties novel to life and its attendant phenomena. The contributions of research this century, achieved by field and laboratory researchers from around the world, have been substantial, indeed revolutionary. It is time to celebrate the progress of our field, to anticipate its significance, and to emphasize conservation of primates in their natural habitats.

The Reception of German Progressive Education in Russia: On Regularities of International Educational Transfer

ERIC Educational Resources Information Center

Mchitarjan, Irina

2015-01-01

This article reports a historical case study of extensive educational transfer: the reception, adaptation, and use of German progressive education and German school reform ideas and practices in Russia at the beginning of the twentieth century. The reception of German educational ideas greatly enriched the theory and practice of the Russian school…

Beyond Subprime Learning: Accelerating Progress in Early Education. Policy Brief

ERIC Educational Resources Information Center

Bornfreund, Laura; McCann, Clare; Williams, Conor; Guernsey, Lisa

2014-01-01

Earlier this year, in "Subprime Learning: Early Education in America since the Great Recession," the current state of early education in the U.S. was surveyed by examining progress over the last five years . It was found that while the public, political, and research consensus is stronger than ever, the field remains in dire need of…

Research in Progress--Update April 1990. Occasional Paper InTER/14/90.

ERIC Educational Resources Information Center

Boots, Maureen, Comp.

This document contains abstracts of 29 research projects in progress in Great Britain divided into six sections: (1) the current phase of Information Technology in Education Research (InTER) programs on groupwork with computers, tools for exploratory learning, conceptual change in science, and bubble dialogue as an ethnographic research tool; (2)…

Data-based Decision-making: Teachers' Comprehension of Curriculum-based Measurement Progress-monitoring Graphs

ERIC Educational Resources Information Center

van den Bosch, Roxette M.; Espin, Christine A.; Chung, Siuman; Saab, Nadira

2017-01-01

Teachers have difficulty using data from Curriculum-based Measurement (CBM) progress graphs of students with learning difficulties for instructional decision-making. As a first step in unraveling those difficulties, we studied teachers' comprehension of CBM graphs. Using think-aloud methodology, we examined 23 teachers' ability to…

24 CFR 598.430 - Revocation of designation.

Code of Federal Regulations, 2011 CFR

2011-04-01

... approval from HUD; (2) Has failed to make progress in implementing the strategic plan; or (3) Has not complied substantially with the strategic plan. (b) Letter of warning. Before revoking the designation of... complying substantially with, or has failed to make progress in implementing the strategic plan; and (2...

24 CFR 598.430 - Revocation of designation.

Code of Federal Regulations, 2010 CFR

2010-04-01

... approval from HUD; (2) Has failed to make progress in implementing the strategic plan; or (3) Has not complied substantially with the strategic plan. (b) Letter of warning. Before revoking the designation of... complying substantially with, or has failed to make progress in implementing the strategic plan; and (2...

Toward a categorical drought prediction system based on U.S. Drought Monitor (USDM) and climate forecast

NASA Astrophysics Data System (ADS)

Hao, Zengchao; Xia, Youlong; Luo, Lifeng; Singh, Vijay P.; Ouyang, Wei; Hao, Fanghua

2017-08-01

Disastrous impacts of recent drought events around the world have led to extensive efforts in drought monitoring and prediction. Various drought information systems have been developed with different indicators to provide early drought warning. The climate forecast from North American Multimodel Ensemble (NMME) has been among the most salient progress in climate prediction and its application for drought prediction has been considerably growing. Since its development in 1999, the U.S. Drought Monitor (USDM) has played a critical role in drought monitoring with different drought categories to characterize drought severity, which has been employed to aid decision making by a wealth of users such as natural resource managers and authorities. Due to wide applications of USDM, the development of drought prediction with USDM drought categories would greatly aid decision making. This study presented a categorical drought prediction system for predicting USDM drought categories in the U.S., based on the initial conditions from USDM and seasonal climate forecasts from NMME. Results of USDM drought categories predictions in the U.S. demonstrate the potential of the prediction system, which is expected to contribute to operational early drought warning in the U.S.

High-Resolution Spectroscopy at the Wyoming Infrared Observatory: Setting TESS Science on FHiRE

NASA Astrophysics Data System (ADS)

Jang-Condell, Hannah; Pierce, Michael J.; Pilachowski, C. A.; Kobulnicky, Henry; McLane, Jacob N.

2018-01-01

The Fiber High Resolution Echelle (FHiRE) spectrograph is a new instrument designed for the 2.3-m Wyoming InfraRed Observatory (WIRO). With the construction of a vacuum chamber for FHiRE to stabilize the spectrograph and a temperature-stabilized Thorium-Argon lamp for precise velocity calibration, we will be able to achieve 1 m/s RV precision, making it an ideal instrument for finding exoplanets. Details of the design of FHiRE are presented in a companion poster (Pierce et al.). The construction of this instrument is well-timed with the planned 2018 launch of NASA's Transiting Exoplanet Survey Satellite (TESS) mission. TESS will require a great deal of follow-up spectroscopy to characterize potential exoplanet host stars as well as radial velocity measurements to confirm new exoplanets. WIRO is ideally suited to acquire the long-term, high-cadence observations that will be required to make progress in this frontier area of astrophysics. We will coordinate our efforts with the TESS Follow-up Observing Program (TFOP), specifically as part of the Recon Spectroscopy and Precise Radial Velocity Work sub-groups.This work is supported by a grant from NASA EPSCOR.

Gray Wave of the Great Transformation: A Satellite View of Urbanization, Climate, and Food Security

NASA Technical Reports Server (NTRS)

Imhoff, Marc L.

2007-01-01

Land cover change driven by human activity is profoundly affecting Earth's natural systems with impacts ranging from a loss of biological productivity to changes in atmospheric chemistry and regional and global climate. This change has been so pervasive and progressed so rapidly, compared to natural processes, scientists refer to it as 'the great transformation'. Urbanization or the 'gray wave' of this transformation is being increasingly recognized as an important process in global climate change. A hallmark of our success as a species, large urban conglomerates do in fact alter their environments so profoundly that the local climate, atmospheric composition, and the basic ecology of the landscape are affected in ways that have consequences to human health and economic well-being. Fortunately we have incredible new tools to observe and understand these processes in ways that can be used to plan and develop enjoyable and sustainable urban places. A suite of Earth observing satellites is making it possible to study the interactions between urbanization, biological processes, and the atmosphere including weather and climate. Using these Earth Observatories we are learning how urban heat islands form and potentially ameliorate them, how urbanization can affect rainfall, pollution, surface water recharge at the local level, and climate and food security globally.

Neurocognitive mechanisms underlying value-based decision-making: from core values to economic value

PubMed Central

Brosch, Tobias; Sander, David

2013-01-01

Value plays a central role in practically every aspect of human life that requires a decision: whether we choose between different consumer goods, whether we decide which person we marry or which political candidate gets our vote, we choose the option that has more value to us. Over the last decade, neuroeconomic research has mapped the neural substrates of economic value, revealing that activation in brain regions such as ventromedial prefrontal cortex (VMPFC), ventral striatum or posterior cingulate cortex reflects how much an individual values an option and which of several options he/she will choose. However, while great progress has been made exploring the mechanisms underlying concrete decisions, neuroeconomic research has been less concerned with the questions of why people value what they value, and why different people value different things. Social psychologists and sociologists have long been interested in core values, motivational constructs that are intrinsically linked to the self-schema and are used to guide actions and decisions across different situations and different time points. Core value may thus be an important determinant of individual differences in economic value computation and decision-making. Based on a review of recent neuroimaging studies investigating the neural representation of core values and their interactions with neural systems representing economic value, we outline a common framework that integrates the core value concept and neuroeconomic research on value-based decision-making. PMID:23898252

[Dealing with diagnostic uncertainty in general practice].

PubMed

Wübken, Magdalena; Oswald, Jana; Schneider, Antonius

2013-01-01

In general, the prevalence of diseases is low in primary care. Therefore, the positive predictive value of diagnostic tests is lower than in hospitals where patients are highly selected. In addition, the patients present with milder forms of disease; and many diseases might hide behind the initial symptom(s). These facts lead to diagnostic uncertainty which is somewhat inherent to general practice. This narrative review discusses different sources of and reasons for uncertainty and strategies to deal with it in the context of the current literature. Fear of uncertainty correlates with higher diagnostic activities. The attitude towards uncertainty correlates with the choice of medical speciality by vocational trainees or medical students. An intolerance of uncertainty, which still increases as medicine is making steady progress, might partly explain the growing shortage of general practitioners. The bio-psycho-social context appears to be important to diagnostic decision-making. The effect of intuition and heuristics are investigated by cognitive psychologists. It is still unclear whether these aspects are prone to bias or useful, which might depend on the context of medical decisions. Good communication is of great importance to share uncertainty with the patients in a transparent way and to alleviate shared decision-making. Dealing with uncertainty should be seen as an important core component of general practice and needs to be investigated in more detail to improve the respective medical decisions. Copyright © 2013. Published by Elsevier GmbH.

Robotics in medicine

NASA Astrophysics Data System (ADS)

Kuznetsov, D. N.; Syryamkin, V. I.

2015-11-01

Modern technologies play a very important role in our lives. It is hard to imagine how people can get along without personal computers, and companies - without powerful computer centers. Nowadays, many devices make modern medicine more effective. Medicine is developing constantly, so introduction of robots in this sector is a very promising activity. Advances in technology have influenced medicine greatly. Robotic surgery is now actively developing worldwide. Scientists have been carrying out research and practical attempts to create robotic surgeons for more than 20 years, since the mid-80s of the last century. Robotic assistants play an important role in modern medicine. This industry is new enough and is at the early stage of development; despite this, some developments already have worldwide application; they function successfully and bring invaluable help to employees of medical institutions. Today, doctors can perform operations that seemed impossible a few years ago. Such progress in medicine is due to many factors. First, modern operating rooms are equipped with up-to-date equipment, allowing doctors to make operations more accurately and with less risk to the patient. Second, technology has enabled to improve the quality of doctors' training. Various types of robots exist now: assistants, military robots, space, household and medical, of course. Further, we should make a detailed analysis of existing types of robots and their application. The purpose of the article is to illustrate the most popular types of robots used in medicine.

Esthetic and prosthetic dentistry as reflected in the Old Testament and other ancient scriptures.

PubMed

Stern, N

1997-01-01

The great technologic strides of the past have transformed medicine and dentistry from a primitive craft into a modern science. Although the past century has witnessed great advances in the evolution of esthetic dentistry, it is fitting to pay tribute to the ancient practitioners of this craft, who formed a basis for its present progress.

Institutional Determinants of Organizational Change in Primary Education in Nineteenth Century America and Britain. Final Report.

ERIC Educational Resources Information Center

Smelser, Neil J.

Using historical documents, this report traces the development of the system of primary education in Great Britain and the United States. During the period between 1810 and 1870, both Britain and the United States attempted to form an organization for primary schooling and achieved great progress in the institutionalization and growth of mass…

10 Great Curricula: Lived Conversations of Progressive, Democratic Curricula in School and Society

ERIC Educational Resources Information Center

Poetter, Thomas S.

2012-01-01

10 Great Curricula is a collection of stories written by educators who have come to understand curricula differently as a result of their engagement with a graduate course and its instructor. The book represents the best of what can be found in teaching and learning, in general, and in the quest for meaningful ways to understand curricula in…

Critical Review of Technical Questions Facing Low Impact Development and Green Infrastructure: A Perspective from the Great Plains.

PubMed

Vogel, Jason R; Moore, Trisha L; Coffman, Reid R; Rodie, Steven N; Hutchinson, Stacy L; McDonough, Kelsey R; McLemore, Alex J; McMaine, John T

2015-09-01

Since its inception, Low Impact Development (LID) has become part of urban stormwater management across the United States, marking progress in the gradual transition from centralized to distributed runoff management infrastructure. The ultimate goal of LID is full, cost-effective implementation to maximize watershed-scale ecosystem services and enhance resilience. To reach that goal in the Great Plains, the multi-disciplinary author team presents this critical review based on thirteen technical questions within the context of regional climate and socioeconomics across increasing complexities in scale and function. Although some progress has been made, much remains to be done including continued basic and applied research, development of local LID design specifications, local demonstrations, and identifying funding mechanisms for these solutions. Within the Great Plains and beyond, by addressing these technical questions within a local context, the goal of widespread acceptance of LID can be achieved, resulting in more effective and resilient stormwater management.

Making Good Instructors Great: USMC Cognitive Readiness and Instructor Professionalization Initiatives

DTIC Science & Technology

2012-01-01

enhance their classes; these approaches are recom- mended in addition to (not in lieu of) other well-known military scenario-based training methods...Interservice/Industry Training , Simulation, and Education Conference (I/ITSEC) 2012 2012 Paper No. 12185 Making Good Instructors Great: USMC...and ambiguous environments. Each of the US Armed Services is addressing cognitive readiness training differently. The Marine Corps, for in- stance

34 CFR 200.20 - Making adequate yearly progress.

Code of Federal Regulations, 2014 CFR

2014-07-01

... adequate yearly progress. A school or LEA makes AYP if it complies with paragraph (c) and with either paragraph (a) or (b) of this section separately in reading/language arts and in mathematics. (a)(1) A school... school or LEA, respectively, meets or exceeds the State's other academic indicators under § 200.19. (2...

34 CFR 200.20 - Making adequate yearly progress.

Code of Federal Regulations, 2013 CFR

2013-07-01

... adequate yearly progress. A school or LEA makes AYP if it complies with paragraph (c) and with either paragraph (a) or (b) of this section separately in reading/language arts and in mathematics. (a)(1) A school... school or LEA, respectively, meets or exceeds the State's other academic indicators under § 200.19. (2...

34 CFR 200.20 - Making adequate yearly progress.

Code of Federal Regulations, 2012 CFR

2012-07-01

... adequate yearly progress. A school or LEA makes AYP if it complies with paragraph (c) and with either paragraph (a) or (b) of this section separately in reading/language arts and in mathematics. (a)(1) A school... school or LEA, respectively, meets or exceeds the State's other academic indicators under § 200.19. (2...

34 CFR 200.20 - Making adequate yearly progress.

Code of Federal Regulations, 2011 CFR

2011-07-01

... adequate yearly progress. A school or LEA makes AYP if it complies with paragraph (c) and with either paragraph (a) or (b) of this section separately in reading/language arts and in mathematics. (a)(1) A school... school or LEA, respectively, meets or exceeds the State's other academic indicators under § 200.19. (2...

Establishing a Strong Foundation for School Improvement. Policy Brief

ERIC Educational Resources Information Center

Jerald, Craig

2005-01-01

In 2002, the No Child Left Behind (NCLB) Act instituted fundamental changes in federal education policy, and states were required to hold schools accountable not simply for making some progress but rather for making sufficient progress in enabling student proficiency on state assessments by 2014. The achievement gaps long plaguing American…

Protease activated receptor 2 in diabetic nephropathy: a double edged sword

PubMed Central

Waasdorp, Maaike; Duitman, JanWillem; Florquin, Sandrine; Spek, Arnold C

2017-01-01

Diabetic nephropathy is a major microvascular complication of diabetes mellitus, and the leading cause of end stage renal disease worldwide. The pathogenesis of diabetic nephropathy is complex, making the development of novel treatments that stop or reverse the progression of microalbuminuria into end stage renal disease a challenge. Protease activated receptor (PAR)-2 has recently been shown to aggravate disease progression in diabetic nephropathy based upon which it was suggested that PAR-2 would be a potential target for the treatment of diabetic nephropathy. To fully appreciate the translational potential of PAR-2 in diabetic nephropathy, we evaluated the effect of PAR-2 deficiency on the development of diabetic nephropathy in a streptozotocin-induced diabetes model characteristic of type 1 diabetes. Although diabetic PAR-2 deficient mice showed reduced albuminuria compared to diabetic wild type mice, an increase in mesangial expansion was evident in the PAR-2 deficient mice. No differences were observed in blood glucose levels, podocyte numbers or in glomerular vascular density. These results show that PAR-2 plays a dual role in the development of streptozotocin-induced diabetic nephropathy and may thus not be the eagerly awaited novel target to combat diabetic nephropathy. Targeting PAR-2 should consequently only be pursued with great care in a clinical setting. PMID:29118913

First steps in experimental cancer evolution

PubMed Central

Taylor, Tiffany B; Johnson, Louise J; Jackson, Robert W; Brockhurst, Michael A; Dash, Philip R

2013-01-01

Evolutionary processes play a central role in the development, progression and response to treatment of cancers. The current challenge facing researchers is to harness evolutionary theory to further our understanding of the clinical progression of cancers. Central to this endeavour will be the development of experimental systems and approaches by which theories of cancer evolution can be effectively tested. We argue here that the experimental evolution approach – whereby evolution is observed in real time and which has typically employed microorganisms – can be usefully applied to cancer. This approach allows us to disentangle the ecological causes of natural selection, identify the genetic basis of evolutionary changes and determine their repeatability. Cell cultures used in cancer research share many of the desirable traits that make microorganisms ideal for studying evolution. As such, experimental cancer evolution is feasible and likely to give great insight into the selective pressures driving the evolution of clinically destructive cancer traits. We highlight three areas of evolutionary theory with importance to cancer biology that are amenable to experimental evolution: drug resistance, social evolution and resource competition. Understanding the diversity, persistence and evolution of cancers is vital for treatment and drug development, and an experimental evolution approach could provide strategic directions and focus for future research. PMID:23745144

Synthesis of Two-Dimensional Materials for Capacitive Energy Storage

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mendoza-Sánchez, Beatriz; Gogotsi, Yury

The unique properties and great variety of two-dimensional (2D) nanomaterials make them highly attractive for energy storage applications. Here, an insight into the progress made towards the application of 2D nanomaterials for capacitive energy storage is provided. Moreover, synthesis methods, and electrochemical performance of various classes of 2D nanomaterials, particularly based on graphene, transition metal oxides, dichalcogenides, and carbides, are presented. Some factors that directly influence capacitive performance are discussed throughout the text and include nanosheet composition, morphology and texture, electrode architecture, and device configuration. Recent progress in the fabrication of 2D-nanomaterials-based microsupercapacitors and flexible and free-standing supercapacitors is presented.more » The main electrode manufacturing techniques with emphasis on scalability and cost-effectiveness are discussed, and include laser scribing, printing, and roll-to-roll manufacture. Some various issues that prevent the use of the full energy-storage potential of 2D nanomaterials and how they have been tackled are discussed, and include nanosheet aggregation and the low electrical conductivity of some 2D nanomaterials. In particular, the design of hybrid and hierarchical 2D and 3D structures based on 2D nanomaterials is presented. Other challenges and opportunities are discussed and include: control of nanosheets size and thickness, chemical and electrochemical instability, and scale-up of electrode films.« less

Synthesis of Two-Dimensional Materials for Capacitive Energy Storage

DOE PAGES

Mendoza-Sánchez, Beatriz; Gogotsi, Yury

2016-06-02

The unique properties and great variety of two-dimensional (2D) nanomaterials make them highly attractive for energy storage applications. Here, an insight into the progress made towards the application of 2D nanomaterials for capacitive energy storage is provided. Moreover, synthesis methods, and electrochemical performance of various classes of 2D nanomaterials, particularly based on graphene, transition metal oxides, dichalcogenides, and carbides, are presented. Some factors that directly influence capacitive performance are discussed throughout the text and include nanosheet composition, morphology and texture, electrode architecture, and device configuration. Recent progress in the fabrication of 2D-nanomaterials-based microsupercapacitors and flexible and free-standing supercapacitors is presented.more » The main electrode manufacturing techniques with emphasis on scalability and cost-effectiveness are discussed, and include laser scribing, printing, and roll-to-roll manufacture. Some various issues that prevent the use of the full energy-storage potential of 2D nanomaterials and how they have been tackled are discussed, and include nanosheet aggregation and the low electrical conductivity of some 2D nanomaterials. In particular, the design of hybrid and hierarchical 2D and 3D structures based on 2D nanomaterials is presented. Other challenges and opportunities are discussed and include: control of nanosheets size and thickness, chemical and electrochemical instability, and scale-up of electrode films.« less

Mapping student thinking in chemical synthesis

NASA Astrophysics Data System (ADS)

Weinrich, Melissa

In order to support the development of learning progressions about central ideas and practices in different disciplines, we need detailed analyses of the implicit assumptions and reasoning strategies that guide students' thinking at different educational levels. In the particular case of chemistry, understanding how new chemical substances are produced (chemical synthesis) is of critical importance. Thus, we have used a qualitative research approach based on individual interviews with first semester general chemistry students (n = 16), second semester organic chemistry students (n = 15), advanced undergraduates (n = 9), first year graduate students (n = 15), and PhD candidates (n = 16) to better characterize diverse students' underlying cognitive elements (conceptual modes and modes of reasoning) when thinking about chemical synthesis. Our results reveal a great variability in the cognitive resources and strategies used by students with different levels of training in the discipline to make decisions, particularly at intermediate levels of expertise. The specific nature of the task had a strong influence on the conceptual sophistication and mode of reasoning that students exhibited. Nevertheless, our data analysis has allowed us to identify common modes of reasoning and assumptions that seem to guide students' thinking at different educational levels. Our results should facilitate the development of learning progressions that help improve chemistry instruction, curriculum, and assessment.

The Promise and the Challenge of Space Solar Power in the 21st Century: Picking up the Gauntlet

NASA Astrophysics Data System (ADS)

Mankins, John C.

2002-01-01

The history of human civilization is a history of great infrastructure. Chief among these developments have been advances in power, transport, and communications. Without dramatic and steady advances in these critical systems during the past two hundred years-- especially in the available sources of power--the world would be a drastically poorer and harsher home for humanity. At the same time, through the global use of existing energy technologies humanity is rapidly consuming irreplaceable fossil resources as well as changing the environment and the climate for the world itself. Both must raise concerns about the long-term sustainability of the infrastructures that have enabled our world. The importance of abundant and affordable energy in space exploration and development is equally clear. Current missions of exploration and scientific discovery are narrowly constrained by a lack of energy. Future, even more ambitious missions will never be realized without new, reliable and less expensive sources of energy. Even more, the potential emergence of new space industries such as space tourism, manufacturing in space, solar power satellites (SPS) and others, will depend on advances in space power systems just as much as they will on progress in space transportation. Recent studies and technological advances suggest that large-scale space solar power (SSP) systems may enable progress in both arenas during the next several decades. Of course, there are tremendous engineering and technological barriers that must be surmounted to someday make large SSP systems possible. Diverse areas of technology must be advanced. Some of these include space transportation, solar power generation, wireless power transmission, robotics, structural concepts and materials, and others. Nevertheless, there are potential benefits in the offing that seem to many to make challenging even these daunting technical barriers worthwhile--and perhaps essential. Unfortunately, the political and programmatic hurdles faced by SSP often seem even greater than the technical difficulties to be faced. The great engineering and technologies projects of the past century provide important lessons--both good and bad-- that bear directly on this challenge. The Peter Glaser Lecture for 2002 will examine from a strategic perspective the challenge and the promise of space solar power, and--in the context of historical examples--suggest directions to advance this vision of almost limitless, clean energy in space and from space for the Earth.

The Relationship between Individual Characteristics and Ideation Behavior: An Empirical Study of Storyboards

ERIC Educational Resources Information Center

Teng, Pei-Shan; Cai, Dengchuan; Yu, Tai-Kuei

2014-01-01

The development of digital technology tool and the progress of animation design activities have led to great progress in the animation field. The storyboard is a type of media used to present animator ideas. Therefore, it is commonly viewed as fundamental to the animation industry. This study aims to discuss cognitive style- and gender-based…

Recent progress in the research field of neuropharmacology in China.

PubMed

Li, Jin

2008-02-01

In recent years, Chinese neuropharmacologists have done a lot of basic and practical work in neuropharmacology, especially in the fields of pain, drug dependence, depression, Alzheimer's disease, schizophrenia, having obtained some exciting results that are of great significance for the development of neuropharmacology. Here I would like to review recent progress in the research fields of neuropharmacology in China.

"The Progressive," the Bomb and the Papers. Journalism Monographs Number Seventy-Six.

ERIC Educational Resources Information Center

Swain, Bruce M.

In the "United States v. the 'Progressive'," the United States government took a small left-wing magazine to court to prevent publication of an article on how a hydrogen bomb works. Amidst great controversy over what the article described and what data were secret and what were not, a federal judge granted an injunction against the…

Implementation of the K-12 Education Reform in Qatar's Schools. Monograph

ERIC Educational Resources Information Center

Zellman, Gail L.; Ryan Gery W.; Karam, Rita; Constant, Louay; Salem, Hanine; Gonzalez, Gabriella; Orr, Nate; Goldman, Charles A.; Al-Thani, Hessa; Al-Obaidli, Kholode

2009-01-01

The leadership of Qatar is greatly invested in its K-12 education reform, "Education for a New Era," because it views education as the key to the nation's economic and social progress. This study, one of a number of RAND studies that trace and document the reform process in Qatar, was designed to assess progress made in the first years…

The Long Path to Higher Education for African Americans

ERIC Educational Resources Information Center

Duster, Troy

2009-01-01

When one considers the possibilities for a new progressive era in American higher education, the author contends that it is wise to review the past because there are lessons to be learned. In fact, the latter part of the 20th century was one of great progress for diversity in higher education, generally speaking, and for African Americans in…

The UK Government's global partnership programme - Its achievements over the past five years and challenges ahead

DOE Office of Scientific and Technical Information (OSTI.GOV)

Heyes, Alan

2007-07-01

Through the Global Partnership the UK continues to make a significant contribution to improve national and global security. Over the past year the UK has continued to implement a wide range of projects across the breadth of its Global Partnership Programme. As well as ensuring the Programme is robust and capable of dealing with new challenges, the UK has cooperated with other donor countries to help them progress projects associated with submarine dismantling, scientist redirection, enhancing nuclear security and Chemical Weapons Destruction. The Global Partnership, although only five years old, has already achieved a great deal. Some 23 states, plusmore » the European Union, are now working closer together under the Global Partnership, and collectively have enhanced global regional and national security by reducing the availability of Weapons of Mass Destruction (WMD) materials and expertise to both states of concern and terrorists. Considerable progress has already been made in, for example: - Improving the security of fissile materials, dangerous biological agents and chemical weapons stocks; - Reducing the number of sites containing radioactive materials; - Working towards closure of reactors still producing weapon-grade plutonium; - Improving nuclear safety to reduce the risks of further, Chernobyl style accidents; - Constructing facilities for destroying Chemical Weapons stocks, and starting actual destruction; - Providing sustainable employment for former WMD scientists to reduce the risk that their expertise will be misused by states or terrorists. By contributing to many of these activities, the UK has helped to make the world safer. This paper reports on the UK's practical and sustainable contribution to the Global Partnership and identifies a number of challenges that remain if it is to have a wider impact on reducing the threats from WMD material. (authors)« less

38 CFR 21.7653 - Progress, conduct, and attendance.

Code of Federal Regulations, 2010 CFR

2010-07-01

... on which the school official who is responsible for determining whether a student is making progress...) Satisfactory pursuit of program. In order to receive educational assistance for pursuit of a program of education, a reservist must maintain satisfactory progress. Progress is unsatisfactory if the reservist does...

The Great Lakes Food Web.

ERIC Educational Resources Information Center

Baker, Marjane L.

1997-01-01

Presents a play for students in grades four to nine that incorporates the scientific names, physical characteristics, feeding habits, interactions, and interdependence of the plants and animals that make up the Great Lakes food web to facilitate the learning of this complex system. Includes a Great Lakes food web chart. (AIM)

Mapping ecosystem services in a Great Lakes estuary supports local decision-making

EPA Science Inventory

Estuaries of the Laurentian Great Lakes provide a concentrated supply of ecosystem goods and services from which humans benefit. As long-term centers of human activity, most estuaries of the Great Lakes and have a legacy of chemical contamination, degraded habitats, and non-point...

Strengthening the Assessment Trajectory: Engaging Educators in the Policy Process. Making a Measurable Difference: Case Studies from the High-Quality Assessment Project

ERIC Educational Resources Information Center

McClellan, Catherine; Snyder, Rebecca; Woods-Murphy, Maryann; Basset, Katherine

2018-01-01

Great teachers recognize great assessments. As policy and education leaders work to make sure state tests are measuring the problem-solving, writing, and critical-thinking skills students need for success, they should convene and rely on teachers to review test quality and help answer the question: Do the questions on our state test reflect…

From School-Culture-to-Family-Culture: Reflections on Four Generations of a Deweyan Education in Hawai'i

ERIC Educational Resources Information Center

Makaiau, Amber Strong

2015-01-01

In 1918, the author's great great aunt, Sophie Judd Cooke founded a small progressive school in Honolulu. Her brother Henry named it Hanahau'oli School, which means joyful work school. In this essay the author's mother, Linda Summers Strong and the author reflect on the impact of Hanahau'oli School's Deweyan approach to education on the…

A Network for Educational Change in the Great Lakes Region: A View through the Lens of Educational Service Agencies

ERIC Educational Resources Information Center

Peters, Randal E.; Svedkauskaite, Asta

2008-01-01

The major purpose of this descriptive report is to provide an overview of the structure, capacity, and roles of educational service agencies (ESAs) across five states--Illinois, Indiana, Michigan, Ohio, and Wisconsin--in the Great Lakes region, within the context of the broader statewide systems of support for educational improvement and progress.…

Moving towards shared decision making in the physician-patient encounter in France: State of the art and future prospects.

PubMed

Moumjid, Nora; Carretier, Julien; Marsico, Giovanna; Blot, François; Durif-Bruckert, Christine; Chauvin, Franck

2017-06-01

In this paper we present the evolution of shared decision making since the mid-nineties in terms of legislation, official statements and guidelines. We outline the goals and declarations of the French Ministry of Health and the French National Authority for Health, for whom informing patients and shared decision-making are central concerns. Finally, we discuss research projects and clinical initiatives in shared decision-making in France and provide a general overview of progress and barriers to progress. Copyright © 2017. Published by Elsevier GmbH.

Understanding psychiatric disorder by capturing ecologically relevant features of learning and decision-making.

PubMed

Scholl, Jacqueline; Klein-Flügge, Miriam

2017-09-28

Recent research in cognitive neuroscience has begun to uncover the processes underlying increasingly complex voluntary behaviours, including learning and decision-making. Partly this success has been possible by progressing from simple experimental tasks to paradigms that incorporate more ecological features. More specifically, the premise is that to understand cognitions and brain functions relevant for real life, we need to introduce some of the ecological challenges that we have evolved to solve. This often entails an increase in task complexity, which can be managed by using computational models to help parse complex behaviours into specific component mechanisms. Here we propose that using computational models with tasks that capture ecologically relevant learning and decision-making processes may provide a critical advantage for capturing the mechanisms underlying symptoms of disorders in psychiatry. As a result, it may help develop mechanistic approaches towards diagnosis and treatment. We begin this review by mapping out the basic concepts and models of learning and decision-making. We then move on to consider specific challenges that emerge in realistic environments and describe how they can be captured by tasks. These include changes of context, uncertainty, reflexive/emotional biases, cost-benefit decision-making, and balancing exploration and exploitation. Where appropriate we highlight future or current links to psychiatry. We particularly draw examples from research on clinical depression, a disorder that greatly compromises motivated behaviours in real-life, but where simpler paradigms have yielded mixed results. Finally, we highlight several paradigms that could be used to help provide new insights into the mechanisms of psychiatric disorders. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

40 CFR 35.938-6 - Progress payments to contractors.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Progress payments to contractors. 35... § 35.938-6 Progress payments to contractors. (a) Policy. EPA policy is that, except as State law otherwise provides, grantees should make prompt progress payments to prime contractors and prime contractors...

20 CFR 411.205 - What if I disagree with the PM's decision about whether I am making timely progress toward self...

Code of Federal Regulations, 2010 CFR

2010-04-01

... about whether I am making timely progress toward self-supporting employment? 411.205 Section 411.205 Employees' Benefits SOCIAL SECURITY ADMINISTRATION THE TICKET TO WORK AND SELF-SUFFICIENCY PROGRAM...-supporting employment? If you disagree with the PM's decision, you may request that we review the decision...

Curriculum-Based Measurement of Reading Progress Monitoring: The Importance of Growth Magnitude and Goal Setting in Decision Making

ERIC Educational Resources Information Center

Van Norman, Ethan R.; Christ, Theodore J.; Newell, Kirsten W.

2017-01-01

Research regarding the technical adequacy of growth estimates from curriculum-based measurement of reading progress monitoring data suggests that current decision-making frameworks are likely to yield inaccurate recommendations unless data are collected for extensive periods of time. Instances where data may not need to be collected for long…

Pieces of the Puzzle: Factors in the Improvement of Urban School Districts on the National Assessment of Educational Progress. Abstract

ERIC Educational Resources Information Center

Casserly, Michael; Price-Baugh, Ricki; Corcoran, Amanda; Lewis, Sharon; Uzzell, Renata; Simon, Candace; Heppen, Jessica; Leinwand, Steve; Salinger, Terry; de Mello, Victor Bandeira; Dogan, Enis; Novotny, Laura

2011-01-01

This is an abridged, summary report of selected findings from "Pieces of the Puzzle: Factors in the Improvement of Urban School Districts on the National Assessment of Educational Progress"--a comprehensive study prepared by the Council of the Great City Schools in collaboration with the American Institutes for Research (AIR) and with…

Ecological monitoring for assessing the state of the nearshore and open waters of the Great Lakes

USGS Publications Warehouse

Neilson, Melanie A.; Painter, D. Scott; Warren, Glenn; Hites, Ronald A.; Basu, Ilora; Weseloh, D.V. Chip; Whittle, D. Michael; Christie, Gavin; Barbiero, Richard; Tuchman, Marc; Johannsson, Ora E.; Nalepa, Thomas F.; Edsall, Thomas A.; Fleischer, Guy; Bronte, Charles; Smith, Stephen B.; Baumann, Paul C.

2003-01-01

The Great Lakes Water Quality Agreement stipulates that the Governments of Canada and the United States are responsible for restoring and maintaining the chemical, physical and biological integrity of the waters of the Great Lakes Basin Ecosystem. Due to varying mandates and areas of expertise, monitoring to assess progress towards this objective is conducted by a multitude of Canadian and U.S. federal and provincial/state agencies, in cooperation with academia and regional authorities. This paper highlights selected long-term monitoring programs and discusses a number of documented ecological changes that indicate the present state of the open and nearshore waters of the Great Lakes.

Critical questions in development of targeted nanoparticle therapeutics.

PubMed

Korsmeyer, Richard

2016-06-01

One of the fourteen Grand Challenges for Engineering articulated by the US National Academy of Engineering is 'Engineer Better Medicines'. Although there are many ways that better medicines could be engineered, one of the most promising ideas is to improve our ability to deliver the therapeutic molecule more precisely to the desired target. Most conventional drug delivery methods (oral absorption, intravenous infusion etc.) result in systemic exposure to the therapeutic molecule, which places severe constraints on the types of molecules that can be used. A molecule administered by systemic delivery must be effective at low concentrations in the target tissue, yet safe everywhere else in the body. If drug carriers could be developed to deliver therapeutic molecules selectively to the desired target, it should be possible to greatly improve safety and efficacy of therapy. Nanoparticles (and related nanostructures, such as liposomes, nanoemulsions, micelles and dendrimers) are an attractive drug carrier concept because they can be made from a variety of materials engineered to have properties that allow loading and precise delivery of bound therapeutic molecules. The field of targeted nanoparticles has been extraordinarily active in the academic realm, with thousands of articles published over the last few years. Many of these publications seem to demonstrate very promising results in in vitro studies and even in animal models. In addition, a handful of human clinical trials are in progress. Yet, the biopharmaceutical industry has been relatively slow to make major investments in targeted nanoparticle development programs, despite a clear desire to introduce innovative new therapies to the market. What is the reason for such caution? Some degree of caution is no doubt due to the use of novel materials and the unproven nature of targeted nanoparticle technology, but many other unproven technologies have generated intense interest at various times. We believe that the major barrier to the exploration of nanoparticles is because they are so complex. The very design flexibility that makes the nanoparticle approach attractive also makes it challenging. Fortunately, continuing progress in experimental tools has greatly improved the ability to study biology and potential interventions at a nanoscale. Thus, it is increasingly possible to answer detailed questions about how nanoparticles can and should work. However, a detailed understanding at the mechanistic level is only the beginning. Any new medicine must not only work at the molecular level, but must also be manufactured reproducibly at scale and proven in the clinic. New materials will require new methods at all scales. The purpose of this short article is to focus on a set of questions that are being asked in the large biopharmaceutical companies and that must be answered if targeted nanoparticles are to become the medicines of the 21st century.

Skip-row Planting Patterns Stabilize Corn Grain Yields in the Central Great Plains

USDA-ARS?s Scientific Manuscript database

The highly variable climate of the Central Great Plains makes dryland corn (Zea mays) production a risky enterprise. Twenty-three field trials were conducted across the Central Great Plains from 2004 through 2006 to quantify the effect of various skip-row planting patterns and plant populations on g...

The Great Womanhunt.

ERIC Educational Resources Information Center

Seltz-Petrash, Ann

1980-01-01

Discusses the aggressive recruitment of women by engineering schools and firms, progress in eliminating sex discrimination barriers, and lingering sex bias problems in the field. Offers suggestions to new women engineering graduates. (SK)

The History of Actual School Lives and the Perspectives of "Learners"--Sickness of Secondary Students and Their Dropping out, in the Age that Lafcadio Hearn Observed--

ERIC Educational Resources Information Center

Saito, Toshihiko

2009-01-01

Numerous historical studies have been done regarding education in modern Japan from a great diversity of viewpoints. It is true that studies of educational systems and history of educational policies have made considerable progress. Still, there remains great room for improvement in terms of both quantity and quality for studies of everyday…

Ability Grouping in English Secondary School: Effects on Attainment in English, Mathematics, and Science.

ERIC Educational Resources Information Center

Ireson, Judith; Hallam, Susan; Hack, Sarah; Clark, Helen; Plewis, Ian

2002-01-01

Studied the impact of ability grouping on attainment in a cohort of year-9 students in 45 mixed secondary schools in England representing a variety of grouping practices. In mathematics, students at higher levels by year 6 make more progress in sets, but those in lower levels make more progress in mixed ability classes. Discusses educational…

How Will I Know What My Students Need? Preparing Preservice Teachers to Use Running Records to Make Instructional Decisions

ERIC Educational Resources Information Center

Gillett, Erin; Ellingson, Susan Pierson

2017-01-01

Effective teachers use assessment data to make instructional decisions. One of the most informative techniques to assess young learners' reading progress in the primary grades is the running record. Running records provide concrete evidence of students' skills, reading levels, strategies, and progress as readers. The data gathered help teachers…

PREFACE: 4th International Conference on Safe Production and Use of Nanomaterials (Nanosafe2014)

NASA Astrophysics Data System (ADS)

Tardif, F.; Damlencourt, J.-F.; Schuster, F.; Gaultier, V.

2015-05-01

This volume contains a collection of contributions presented at the 4th International Conference on Safe Production and Use of Nanomaterials (NANOSAFE 2014) held in Grenoble, France, from 18th to 20th November 2014. The issues of fast progress in the field of Nanosafety are up to the potential benefits that nanotechnology can bring to mankind. Making more efficient - more sustainable - easier to share mineral resources, increasing the yields of new energy technologies, enabling drugs that act selectively and locally are just few examples of the wide range of nanomaterial applications that currently benefit humanity. Nevertheless, the dynamic development of nanomaterials requires the adhesion from the general public who rightly demand major progresses in Nanosafety as a prerequisite. This is our exciting responsibility and challenge! Following the successful outcome of the three past international conferences on safe production and use of nanomaterials: Nanosafe 2008, 2010 and 2012, the organizing committee has the pleasure to welcoming you again to Minatec, Grenoble with some of the most famous specialists in the field. This year, two new topics have been added dealing with the "New Application of Nanomaterials" and "Nano-responsible Development" in addition to the usual issues addressed in previous Nanosafe conferences such as Expology, Detection and Characterization, Toxicology, Environmental Interactions, Nanomaterials Release, Life Cycle Analysis, Regulation and Standardization, Risk Management. The debates in 2012 proved highly successful so this formula has been kept in 2014 with 3 round tables: Nano-Responsible Development, Risks and Benefits for the Environment, Toxicology Progress. In this 4th edition, there were more than 330 registered participants from 28 different countries including 160 oral presentation covering the whole Nanosafety issues in 12 sessions, satellite workshops and round tables. This high number of participants makes this edition one of the most successful conference of the series. Finally, 2014 was for the organizing committee, a great year as we ramp up the Nano Safety "PNS" platform at Minatec, with a brand new building spread out over 2000 m2 of laboratories and more than 50 doctors and engineers dedicated to Nanosafety. F. Tardif, J-F. Damlencourt, F. Schuster and V. Gaultier

Research advances in major cereal crops for adaptation to abiotic stresses

PubMed Central

Maiti, RK; Satya, Pratik

2014-01-01

With devastating increase in population there is a great necessity to increase crop productivity of staple crops but the productivity is greatly affected by various abiotic stress factors such as drought, salinity. An attempt has been made a brief account on abiotic stress resistance of major cereal crops viz. In spite of good successes obtained on physiological and use molecular biology, the benefits of this high cost technology are beyond the reach of developing countries. This review discusses several morphological, anatomical, physiological, biochemical and molecular mechanisms of major cereal crops related to the adaptation of these crop to abiotic stress factors. It discusses the effect of abiotic stresses on physiological processes such as flowering, grain filling and maturation and plant metabolisms viz. photosynthesis, enzyme activity, mineral nutrition, and respiration. Though significant progress has been attained on the physiological, biochemical basis of resistance to abiotic stress factors, very little progress has been achieved to increase productivity under sustainable agriculture. Therefore, there is a great necessity of inter-disciplinary research to address this issue and to evolve efficient technology and its transfer to the farmers’ fields. PMID:25523172

Research advances in major cereal crops for adaptation to abiotic stresses.

PubMed

Maiti, R K; Satya, Pratik

2014-01-01

With devastating increase in population there is a great necessity to increase crop productivity of staple crops but the productivity is greatly affected by various abiotic stress factors such as drought, salinity. An attempt has been made a brief account on abiotic stress resistance of major cereal crops viz. In spite of good successes obtained on physiological and use molecular biology, the benefits of this high cost technology are beyond the reach of developing countries. This review discusses several morphological, anatomical, physiological, biochemical and molecular mechanisms of major cereal crops related to the adaptation of these crop to abiotic stress factors. It discusses the effect of abiotic stresses on physiological processes such as flowering, grain filling and maturation and plant metabolisms viz. photosynthesis, enzyme activity, mineral nutrition, and respiration. Though significant progress has been attained on the physiological, biochemical basis of resistance to abiotic stress factors, very little progress has been achieved to increase productivity under sustainable agriculture. Therefore, there is a great necessity of inter-disciplinary research to address this issue and to evolve efficient technology and its transfer to the farmers' fields.

Recent progress of quantum annealing

DOE Office of Scientific and Technical Information (OSTI.GOV)

Suzuki, Sei

2015-03-10

We review the recent progress of quantum annealing. Quantum annealing was proposed as a method to solve generic optimization problems. Recently a Canadian company has drawn a great deal of attention, as it has commercialized a quantum computer based on quantum annealing. Although the performance of quantum annealing is not sufficiently understood, it is likely that quantum annealing will be a practical method both on a conventional computer and on a quantum computer.

Significance of perivascular tumour cells defined by CD109 expression in progression of glioma.

PubMed

Shiraki, Yukihiro; Mii, Shinji; Enomoto, Atsushi; Momota, Hiroyuki; Han, Yi-Peng; Kato, Takuya; Ushida, Kaori; Kato, Akira; Asai, Naoya; Murakumo, Yoshiki; Aoki, Kosuke; Suzuki, Hiromichi; Ohka, Fumiharu; Wakabayashi, Toshihiko; Todo, Tomoki; Ogawa, Seishi; Natsume, Atsushi; Takahashi, Masahide

2017-12-01

In the progression of glioma, tumour cells often exploit the perivascular microenvironment to promote their survival and resistance to conventional therapies. Some of these cells are considered to be brain tumour stem cells (BTSCs); however, the molecular nature of perivascular tumour cells has not been specifically clarified because of the complexity of glioma. Here, we identified CD109, a glycosylphosphatidylinositol-anchored protein and regulator of multiple signalling pathways, as a critical regulator of the progression of lower-grade glioma (World Health Organization grade II/III) by clinicopathological and whole-genome sequencing analysis of tissues from human glioma. The importance of CD109-positive perivascular tumour cells was confirmed not only in human lower-grade glioma tissues but also in a mouse model that recapitulated human glioma. Intriguingly, BTSCs isolated from mouse glioma expressed high levels of CD109. CD109-positive BTSCs exerted a proliferative effect on differentiated glioma cells treated with temozolomide. These data reveal the significance of tumour cells that populate perivascular regions during glioma progression, and indicate that CD109 is a potential therapeutic target for the disease. Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

A good Darwinian? Winwood Reade and the making of a late Victorian evolutionary epic.

PubMed

Hesketh, Ian

2015-06-01

In 1871 the travel writer and anthropologist W. Winwood Reade (1838-1875) was inspired by his correspondence with Darwin to turn his narrow ethnological research on West African tribes into the broadest history imaginable, one that would show Darwin's great principle of natural selection at work throughout the evolutionary history of humanity, stretching back to the origins of the universe itself. But when Martyrdom of Man was published in 1872, Reade confessed that Darwin would not likely find him a very good Darwinian, as he was unable to show that natural selection was anything more than a secondary law that arranges all details. When it came to historicising humans within the sweeping history of all creation, Reade argued that the primary law was that of development, a less contentious theory of human evolution that was better suited to Reade's progressive and teleological history of life. By focussing on the extensive correspondence between Reade and Darwin, this paper reconstructs the attempt to make an explicitly Darwinian evolutionary epic in order to shed light on the moral and aesthetic demands that worked to give shape to Victorian efforts to historicise humans within a vastly expanding timeframe. Copyright © 2015 Elsevier Ltd. All rights reserved.

Research into the usage of integrated jamming of IR weakening and smoke-screen resisting the IR imaging guided missiles

NASA Astrophysics Data System (ADS)

Wang, Long-tao; Jiang, Ning; Lv, Ming-shan

2015-10-01

With the emergence of the anti-ship missle with the capability of infrared imaging guidance, the traditional single jamming measures, because of the jamming mechanism and technical flaws or unsuitable use, greatly reduced the survival probability of the war-ship in the future naval battle. Intergrated jamming of IR weakening + smoke-screen Can not only make jamming to the search and tracking of IR imaging guidance system , but also has feasibility in conjunction, besides , which also make the best jamming effect. The research conclusion has important realistic meaning for raising the antimissile ability of surface ships. With the development of guidance technology, infrared guidance system has expanded by ir point-source homing guidance to infrared imaging guidance, Infrared imaging guidance has made breakthrough progress, Infrared imaging guidance system can use two-dimensional infrared image information of the target, achieve the precise tracking. Which has Higher guidance precision, better concealment, stronger anti-interference ability and could Target the key parts. The traditional single infrared smoke screen jamming or infrared decoy flare interference cannot be imposed effective interference. So, Research how to effectively fight against infrared imaging guided weapons threat measures and means, improving the surface ship antimissile ability is an urgent need to solve.

Multi-agent planning and scheduling, execution monitoring and incremental rescheduling: Application to motorway traffic

NASA Technical Reports Server (NTRS)

Mourou, Pascal; Fade, Bernard

1992-01-01

This article describes a planning method applicable to agents with great perception and decision-making capabilities and the ability to communicate with other agents. Each agent has a task to fulfill allowing for the actions of other agents in its vicinity. Certain simultaneous actions may cause conflicts because they require the same resource. The agent plans each of its actions and simultaneously transmits these to its neighbors. In a similar way, it receives plans from the other agents and must take account of these plans. The planning method allows us to build a distributed scheduling system. Here, these agents are robot vehicles on a highway communicating by radio. In this environment, conflicts between agents concern the allocation of space in time and are connected with the inertia of the vehicles. Each vehicle made a temporal, spatial, and situated reasoning in order to drive without collision. The flexibility and reactivity of the method presented here allows the agent to generate its plan based on assumptions concerning the other agents and then check these assumptions progressively as plans are received from the other agents. A multi-agent execution monitoring of these plans can be done, using data generated during planning and the multi-agent decision-making algorithm described here. A selective backtrack allows us to perform incremental rescheduling.

Strongly Interacting Matter at Very High Energy Density

DOE Office of Scientific and Technical Information (OSTI.GOV)

McLerran, L.

2011-06-05

The authors discuss the study of matter at very high energy density. In particular: what are the scientific questions; what are the opportunities to makes significant progress in the study of such matter and what facilities are now or might be available in the future to answer the scientific questions? The theoretical and experimental study of new forms of high energy density matter is still very much a 'wild west' field. There is much freedom for developing new concepts which can have order one effects on the way we think about such matter. It is also a largely 'lawless' field,more » in that concepts and methods are being developed as new information is generated. There is also great possibility for new experimental discovery. Most of the exciting results from RHIC experiments were unanticipated. The methods used for studying various effects like flow, jet quenching, the ridge, two particle correlations etc. were developed as experiments evolved. I believe this will continue to be the case at LHC and as we use existing and proposed accelerators to turn theoretical conjecture into tangible reality. At some point this will no doubt evolve into a precision science, and that will make the field more respectable, but for my taste, the 'wild west' times are the most fun.« less

Simulation as a preoperative planning approach in advanced heart failure patients. A retrospective clinical analysis.

PubMed

Capoccia, Massimo; Marconi, Silvia; Singh, Sanjeet Avtaar; Pisanelli, Domenico M; De Lazzari, Claudio

2018-05-02

Modelling and simulation may become clinically applicable tools for detailed evaluation of the cardiovascular system and clinical decision-making to guide therapeutic intervention. Models based on pressure-volume relationship and zero-dimensional representation of the cardiovascular system may be a suitable choice given their simplicity and versatility. This approach has great potential for application in heart failure where the impact of left ventricular assist devices has played a significant role as a bridge to transplant and more recently as a long-term solution for non eligible candidates. We sought to investigate the value of simulation in the context of three heart failure patients with a view to predict or guide further management. CARDIOSIM © was the software used for this purpose. The study was based on retrospective analysis of haemodynamic data previously discussed at a multidisciplinary meeting. The outcome of the simulations addressed the value of a more quantitative approach in the clinical decision process. Although previous experience, co-morbidities and the risk of potentially fatal complications play a role in clinical decision-making, patient-specific modelling may become a daily approach for selection and optimisation of device-based treatment for heart failure patients. Willingness to adopt this integrated approach may be the key to further progress.

Pattern of retinal morphological and functional decay in a light-inducible, rhodopsin mutant mouse.

PubMed

Gargini, Claudia; Novelli, Elena; Piano, Ilaria; Biagioni, Martina; Strettoi, Enrica

2017-07-18

Hallmarks of Retinitis Pigmentosa (RP), a family of genetic diseases, are a typical rod-cone-degeneration with initial night blindness and loss of peripheral vision, followed by decreased daylight sight and progressive visual acuity loss up to legal blindness. Great heterogeneity in nature and function of mutated genes, variety of mutations for each of them, variability in phenotypic appearance and transmission modality contribute to make RP a still incurable disease. Translational research relies on appropriate animal models mimicking the genetic and phenotypic diversity of the human pathology. Here, we provide a systematic, morphological and functional analysis of Rho Tvrm4 /Rho + rhodopsin mutant mice, originally described in 2010 and portraying several features of common forms of autosomal dominant RP caused by gain-of-function mutations. These mice undergo photoreceptor degeneration only when exposed briefly to strong, white light and allow controlled timing of induction of rod and cone death, which therefore can be elicited in adult animals, as observed in human RP. The option to control severity and retinal extent of the phenotype by regulating intensity and duration of the inducing light opens possibilities to exploit this model for multiple experimental purposes. Altogether, the unique features of this mutant make it an excellent resource for retinal degeneration research.

A Real-Time Method to Estimate Speed of Object Based on Object Detection and Optical Flow Calculation

NASA Astrophysics Data System (ADS)

Liu, Kaizhan; Ye, Yunming; Li, Xutao; Li, Yan

2018-04-01

In recent years Convolutional Neural Network (CNN) has been widely used in computer vision field and makes great progress in lots of contents like object detection and classification. Even so, combining Convolutional Neural Network, which means making multiple CNN frameworks working synchronously and sharing their output information, could figure out useful message that each of them cannot provide singly. Here we introduce a method to real-time estimate speed of object by combining two CNN: YOLOv2 and FlowNet. In every frame, YOLOv2 provides object size; object location and object type while FlowNet providing the optical flow of whole image. On one hand, object size and object location help to select out the object part of optical flow image thus calculating out the average optical flow of every object. On the other hand, object type and object size help to figure out the relationship between optical flow and true speed by means of optics theory and priori knowledge. Therefore, with these two key information, speed of object can be estimated. This method manages to estimate multiple objects at real-time speed by only using a normal camera even in moving status, whose error is acceptable in most application fields like manless driving or robot vision.

Bioprinting for vascular and vascularized tissue biofabrication.

PubMed

Datta, Pallab; Ayan, Bugra; Ozbolat, Ibrahim T

2017-03-15

Bioprinting is a promising technology to fabricate design-specific tissue constructs due to its ability to create complex, heterocellular structures with anatomical precision. Bioprinting enables the deposition of various biologics including growth factors, cells, genes, neo-tissues and extra-cellular matrix-like hydrogels. Benefits of bioprinting have started to make a mark in the fields of tissue engineering, regenerative medicine and pharmaceutics. Specifically, in the field of tissue engineering, the creation of vascularized tissue constructs has remained a principal challenge till date. However, given the myriad advantages over other biofabrication methods, it becomes organic to expect that bioprinting can provide a viable solution for the vascularization problem, and facilitate the clinical translation of tissue engineered constructs. This article provides a comprehensive account of bioprinting of vascular and vascularized tissue constructs. The review is structured as introducing the scope of bioprinting in tissue engineering applications, key vascular anatomical features and then a thorough coverage of 3D bioprinting using extrusion-, droplet- and laser-based bioprinting for fabrication of vascular tissue constructs. The review then provides the reader with the use of bioprinting for obtaining thick vascularized tissues using sacrificial bioink materials. Current challenges are discussed, a comparative evaluation of different bioprinting modalities is presented and future prospects are provided to the reader. Biofabrication of living tissues and organs at the clinically-relevant volumes vitally depends on the integration of vascular network. Despite the great progress in traditional biofabrication approaches, building perfusable hierarchical vascular network is a major challenge. Bioprinting is an emerging technology to fabricate design-specific tissue constructs due to its ability to create complex, heterocellular structures with anatomical precision, which holds a great promise in fabrication of vascular or vascularized tissues for transplantation use. Although a great progress has recently been made on building perfusable tissues and branched vascular network, a comprehensive review on the state-of-the-art in vascular and vascularized tissue bioprinting has not reported so far. This contribution is thus significant because it discusses the use of three major bioprinting modalities in vascular tissue biofabrication for the first time in the literature and compares their strengths and limitations in details. Moreover, the use of scaffold-based and scaffold-free bioprinting is expounded within the domain of vascular tissue fabrication. Copyright © 2017 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

Nano-biosensing approaches on tuberculosis: Defy of aptamers.

PubMed

Golichenari, Behrouz; Nosrati, Rahim; Farokhi-Fard, Aref; Abnous, Khalil; Vaziri, Farzam; Behravan, Javad

2018-06-11

Tuberculosis is a major global health problem caused by the bacterium Mycobacterium tuberculosis (Mtb) complex. According to WHO reports, 53 million TB patients died from 2000 to 2016. Therefore, early diagnosis of the disease is of great importance for global health care programs. The restrictions of traditional methods have encouraged the development of innovative methods for rapid, reliable, and cost-effective diagnosis of tuberculosis. In recent years, aptamer-based biosensors or aptasensors have drawn great attention to sensitive and accessible detection of tuberculosis. Aptamers are small short single-stranded molecules of DNA or RNA that fold to a unique form and bind to targets. Once combined with nanomaterials, nano-scale aptasensors provide powerful analytical platforms for diagnosing of tuberculosis. Various groups designed and studied aptamers specific for the whole cells of M. tuberculosis, mycobacterial proteins and IFN-γ for early diagnosis of TB. Advantages such as high specificity and strong affinity, potential for binding to a larger variety of targets, increased stability, lower costs of synthesis and storage requirements, and lower probability of contamination make aptasensors pivotal alternatives for future TB diagnostics. In recent years, the concept of SOMAmer has opened new horizons in high precision detection of tuberculosis biomarkers. This review article provides a description of the research progresses of aptamer-based and SOMAmer-based biosensors and nanobiosensors for the detection of tuberculosis. Copyright © 2018 Elsevier B.V. All rights reserved.

3D simulation as a tool for improving the safety culture during remediation work at Andreeva Bay.

PubMed

Chizhov, K; Sneve, M K; Szőke, I; Mazur, I; Mark, N K; Kudrin, I; Shandala, N; Simakov, A; Smith, G M; Krasnoschekov, A; Kosnikov, A; Kemsky, I; Kryuchkov, V

2014-12-01

Andreeva Bay in northwest Russia hosts one of the former coastal technical bases of the Northern Fleet. Currently, this base is designated as the Andreeva Bay branch of Northwest Center for Radioactive Waste Management (SevRAO) and is a site of temporary storage (STS) for spent nuclear fuel (SNF) and other radiological waste generated during the operation and decommissioning of nuclear submarines and ships. According to an integrated expert evaluation, this site is the most dangerous nuclear facility in northwest Russia. Environmental rehabilitation of the site is currently in progress and is supported by strong international collaboration. This paper describes how the optimization principle (ALARA) has been adopted during the planning of remediation work at the Andreeva Bay STS and how Russian-Norwegian collaboration greatly contributed to ensuring the development and maintenance of a high level safety culture during this process. More specifically, this paper describes how integration of a system, specifically designed for improving the radiological safety of workers during the remediation work at Andreeva Bay, was developed in Russia. It also outlines the 3D radiological simulation and virtual reality based systems developed in Norway that have greatly facilitated effective implementation of the ALARA principle, through supporting radiological characterisation, work planning and optimization, decision making, communication between teams and with the authorities and training of field operators.

White paper on science operations

NASA Technical Reports Server (NTRS)

Schreier, Ethan J.

1991-01-01

Major changes are taking place in the way astronomy gets done. There are continuing advances in observational capabilities across the frequency spectrum, involving both ground-based and space-based facilities. There is also very rapid evolution of relevant computing and data management technologies. However, although the new technologies are filtering in to the astronomy community, and astronomers are looking at their computing needs in new ways, there is little coordination or coherent policy. Furthermore, although there is great awareness of the evolving technologies in the arena of operations, much of the existing operations infrastructure is ill-suited to take advantage of them. Astronomy, especially space astronomy, has often been at the cutting edge of computer use in data reduction and image analysis, but has been somewhat removed from advanced applications in operations, which have tended to be implemented by industry rather than by the end-user scientists. The purpose of this paper is threefold. First, we briefly review the background and general status of astronomy-related computing. Second, we make recommendations in three areas: data analysis; operations (directed primarily to NASA-related activities); and issues of management and policy, believing that these must be addressed to enable technological progress and to proceed through the next decade. Finally, we recommend specific NASA-related work as part of the Astrotech-21 plans, to enable better science operations in the operations of the Great Observatories and in the lunar outpost era.

40 CFR 35.938-6 - Progress payments to contractors.

Code of Federal Regulations, 2014 CFR

2014-07-01

... FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Grants for Construction of Treatment Works-Clean Water Act... should make prompt progress payment to subcontractors and suppliers for eligible construction, material... under a contract under an EPA construction grant. (b) Conditions of progress payments. For purposes of...

Physics division annual report 2005.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Glover, J.; Physics

2007-03-12

This report highlights the research performed in 2005 in the Physics Division of Argonne National Laboratory. The Division's programs include operation of ATLAS as a national user facility, nuclear structure and reaction research, nuclear theory, medium energy nuclear research and accelerator research and development. The mission of Nuclear Physics is to understand the origin, evolution and structure of baryonic matter in the universe--the matter that makes up stars, planets and human life itself. The Division's research focuses on innovative new ways to address this mission and 2005 was a year of great progress. One of the most exciting developments ismore » the initiation of the Californium Rare Ion Breeder Upgrade, CARIBU. By combining a Cf-252 fission source, the gas catcher technology developed for rare isotope beams, a high-resolution isobar separator, and charge breeding ECR technology, CARIBU will make hundreds of new neutron-rich isotope beams available for research. The cover illustration shows the anticipated intensities of low-energy beams that become available for low-energy experiments and for injection into ATLAS for reacceleration. CARIBU will be completed in early 2009 and provide us with considerable experience in many of the technologies developed for a future high intensity exotic beam facility. Notable results in research at ATLAS include a measurement of the isomeric states in {sup 252}No that helps pin down the single particle structure expected for superheavy elements, and a new low-background measurement of {sup 16}N beta-decay to determine the {sup 12}C({alpha},{gamma}){sup 16}O reaction rate that is so important in astrophysical environments. Precise mass measurements shed new light on the unitarity of the quark weak-mixing matrix in the search for physics beyond the standard model. ATLAS operated for 4686 hours of research in FY2005 while achieving 95% efficiency of beam delivery for experiments. In Medium-Energy Physics, radium isotopes were trapped in an atom trap for the first time, a major milestone in an innovative search for the violation of time-reversal symmetry. New results from HERMES establish that strange quarks carry little of the spin of the proton and precise results have been obtained at JLAB on the changes in quark distributions in light nuclei. New theoretical results reveal that the nature of the surfaces of strange quark stars. Green's function Monte Carlo techniques have been extended to scattering problems and show great promise for the accurate calculation, from first principles, of important astrophysical reactions. Flame propagation in type 1A supernova has been simulated, a numerical process that requires considering length scales that vary by factors of eight to twelve orders of magnitude. Argonne continues to lead in the development and exploitation of the new technical concepts that will truly make an advanced exotic beam facility, in the words of NSAC, 'the world-leading facility for research in nuclear structure and nuclear astrophysics'. Our science and our technology continue to point the way to this major advance. It is a tremendously exciting time in science for these new capabilities hold the keys to unlocking important secrets of nature. The great progress that has been made in meeting the exciting intellectual challenges of modern nuclear physics reflects the talents and dedication of the Physics Division staff and the visitors, guests and students who bring so much to the research.« less

Reflective Decision Making among University Department Heads across Academic Disciplines

ERIC Educational Resources Information Center

Kampmann, Jennifer A.

2012-01-01

Within the scope of leadership and management, decision making greatly defines the role of university administrator, in particular, the university department head and his/her ability to be a reflective practitioner in the realm of decision making. Decision making is one characteristic of university department head work which warrants close…

Role of nanotechnology in HIV/AIDS vaccine development.

PubMed

Liu, Ying; Chen, Chunying

2016-08-01

HIV/AIDS is one of the worst crises affecting global health and influencing economic development and social stability. Preventing and treating HIV infection is a crucial task. However, there is still no effective HIV vaccine for clinical application. Nanotechnology has the potential to solve the problems associated with traditional HIV vaccines. At present, various nano-architectures and nanomaterials can function as potential HIV vaccine carriers or adjuvants, including inorganic nanomaterials, liposomes, micelles and polymer nanomaterials. In this review, we summarize the current progress in the use of nanotechnology for the development of an HIV/AIDS vaccine and discuss its potential to greatly improve the solubility, permeability, stability and pharmacokinetics of HIV vaccines. Although nanotechnology holds great promise for applications in HIV/AIDS vaccines, there are still many inadequacies that result in a variety of risks and challenges. The potential hazards to the human body and environment associated with some nano-carriers, and their underlying mechanisms require in-depth study. Non-toxic or low-toxic nanomaterials with adjuvant activity have been identified. However, studying the confluence of factors that affect the adjuvant activity of nanomaterials may be more important for the optimization of the dosage and immunization strategy and investigations into the exact mechanism of action. Moreover, there are no uniform standards for investigations of nanomaterials as potential vaccine adjuvants. These limitations make it harder to analyze and deduce rules from the existing data. Developing vaccine nano-carriers or adjuvants with high benefit-cost ratios is important to ensure their broad usage. Despite some shortcomings, nanomaterials have great potential and application prospects in the fields of AIDS treatment and prevention. Copyright © 2016 Elsevier B.V. All rights reserved.

Enhancing Earth Observation and Modeling for Tsunami Disaster Response and Management

NASA Astrophysics Data System (ADS)

Koshimura, Shunichi; Post, Joachim

2017-04-01

In the aftermath of catastrophic natural disasters, such as earthquakes and tsunamis, our society has experienced significant difficulties in assessing disaster impact in the limited amount of time. In recent years, the quality of satellite sensors and access to and use of satellite imagery and services has greatly improved. More and more space agencies have embraced data-sharing policies that facilitate access to archived and up-to-date imagery. Tremendous progress has been achieved through the continuous development of powerful algorithms and software packages to manage and process geospatial data and to disseminate imagery and geospatial datasets in near-real time via geo-web-services, which can be used in disaster-risk management and emergency response efforts. Satellite Earth observations now offer consistent coverage and scope to provide a synoptic overview of large areas, repeated regularly. These can be used to compare risk across different countries, day and night, in all weather conditions, and in trans-boundary areas. On the other hand, with use of modern computing power and advanced sensor networks, the great advances of real-time simulation have been achieved. The data and information derived from satellite Earth observations, integrated with in situ information and simulation modeling provides unique value and the necessary complement to socio-economic data. Emphasis also needs to be placed on ensuring space-based data and information are used in existing and planned national and local disaster risk management systems, together with other data and information sources as a way to strengthen the resilience of communities. Through the case studies of the 2011 Great East Japan earthquake and tsunami disaster, we aim to discuss how earth observations and modeling, in combination with local, in situ data and information sources, can support the decision-making process before, during and after a disaster strikes.

Tales of the Earth - Paroxysms and Perturbations of the Blue Planet

NASA Astrophysics Data System (ADS)

Officer, Charles; Page, Jake

1994-05-01

In Maryland, late in the Spring of 1816, the snow fell brown, and blue, and even red. Brown snow fell in Hungary that year, and in the village of Taranto in southern Italy, where any snow is rare, the red and yellow snow caused great alarm. In New England, 1816 was called the Year Without a Summer. Crops failed throughout America, the price of corn and wheat soared, and farmers (lacking feed) sold off livestock, bringing about a collapse in beef and pork prices. In western Europe it was even worse, with food riots and armed mobs raiding bakeries and grain markets. This turmoil followed a catastrophic volcanic eruption a year earlier on the other side of the world--the April 1815 explosion of the volcano Tambora, on the Indonesian island of Sumbawa--a blast heard almost a thousand miles away in Sumatra. In Tales of the Earth , Charles Officer and Jake Page describe--often through eye-witness accounts and through the commentary of prominent figures--some of the great events of environmental history. From natural catastrophes such as the Tambora eruption, the great Lisbon earthquake of 1755, and the ice ages, to manmade disasters such as the nuclear fallout from Chernobyl, the killer smog of 1952 in London which killed some four thousand people, acid rain, and the progressive depletion of the ozone layer, Officer and Page provide phenomenal accounts of the earthshattering events that have changed the course of history. A fascinating discussion of natures power over humanity, as well as the trouble humanity makes for nature, Tales of the Earth will interest anyone concerned with the environmental and the natural world.

Accelerated construction of a regional DNA-barcode reference library: Caddisflies (Trichoptera) in the Great Smoky Mountains National Park

USGS Publications Warehouse

Zhou, X.; Robinson, J.L.; Geraci, C.J.; Parker, C.R.; Flint, O.S.; Etnier, D.A.; Ruiter, D.; DeWalt, R.E.; Jacobus, L.M.; Hebert, P.D.N.

2011-01-01

Deoxyribonucleic acid (DNA) barcoding is an effective tool for species identification and lifestage association in a wide range of animal taxa. We developed a strategy for rapid construction of a regional DNA-barcode reference library and used the caddisflies (Trichoptera) of the Great Smoky Mountains National Park (GSMNP) as a model. Nearly 1000 cytochrome c oxidase subunit I (COI) sequences, representing 209 caddisfly species previously recorded from GSMNP, were obtained from the global Trichoptera Barcode of Life campaign. Most of these sequences were collected from outside the GSMNP area. Another 645 COI sequences, representing 80 species, were obtained from specimens collected in a 3-d bioblitz (short-term, intense sampling program) in GSMNP. The joint collections provided barcode coverage for 212 species, 91% of the GSMNP fauna. Inclusion of samples from other localities greatly expedited construction of the regional DNA-barcode reference library. This strategy increased intraspecific divergence and decreased average distances to nearest neighboring species, but the DNA-barcode library was able to differentiate 93% of the GSMNP Trichoptera species examined. Global barcoding projects will aid construction of regional DNA-barcode libraries, but local surveys make crucial contributions to progress by contributing rare or endemic species and full-length barcodes generated from high-quality DNA. DNA taxonomy is not a goal of our present work, but the investigation of COI divergence patterns in caddisflies is providing new insights into broader biodiversity patterns in this group and has directed attention to various issues, ranging from the need to re-evaluate species taxonomy with integrated morphological and molecular evidence to the necessity of an appropriate interpretation of barcode analyses and its implications in understanding species diversity (in contrast to a simple claim for barcoding failure).

Oil taxation and risks

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rodriguez-Padilla, V.

1992-01-01

The relationship between the taxation system and the division of risks between the host country governments and the international companies is discussed. The analysis underscores the effect of taxation on the geological and political risks. These two cases are evaluated in two West-African oil-producing countries. It emerges from this that too heavy and regressive taxes greatly increase the risks supported by the two partners. The progressive character of the taxation is a necessary but not a sufficient condition for the reduction of public and private risks. A taxation burden well-balanced among small and large deposits is the best way tomore » reduce the risk due to taxation. The oil-producing countries of this region had made great advances in developing neutral taxation systems but in most cases they must progress further. 15 refs., 3 figs., 1 tab.« less

The U.K. Pushes the Boundaries of Bionics: Researchers and Engineers Are Making Great Strides Toward Advanced Prosthetics' Ultimate Goal-Mimicking the Functionality of a Real Limb.

PubMed

Banks, Jim

2016-01-01

Using state-of-the-art technology, athletes at the Paralympic Games achieve great feats of physical prowess, but for most people using assistive and rehabilitative technologies (ART), even simple tasks can present huge challenges. Many do not make full use of the technology available to them because it is unreliable, uncomfortable, and nonintuitive, so researchers are pushing the envelope to create practical solutions that function like real limbs.

The future of planetary defense

NASA Astrophysics Data System (ADS)

Mainzer, A.

2017-04-01

Asteroids and comets have impacted Earth in the past and will do so in the future. While the frequency of impacts is reasonably well understood on geologic timescales, it is difficult to predict the next sizeable impact on human timescales by extrapolation from population statistics alone. Fortunately, by identifying and tracking individual objects, we can make precise predictions of any potential close encounters with Earth. As more advance notice is provided, the range of possible mitigation options expands. While the chance of an impact is very small, the potential consequences can be severe, meaning that sensible risk reduction measures should be undertaken. By implementing surveys, the risk of an unforeseen impact can be greatly reduced: the first step is finding the objects. Fortunately, the worldwide community of professional and amateur astronomers has made significant progress in discovering large near-Earth objects (NEOs). More than 95% of NEOs capable of causing global devastation (objects larger than 1 km in diameter) have been discovered, and none of these pose an impact hazard in the near future. Infrastructure is in place to link observations and compute close approaches in real time. Interagency and international collaborations have been undertaken to strengthen cooperative efforts to plan potential mitigation and civil defense campaigns. Yet much remains to be done. Approximately 70% of NEOs larger than 140 m (large enough to cause severe regional damage) remain undiscovered. With the existing surveys, it will take decades to identify the rest. Progress can be accelerated by undertaking new surveys with improved sensitivity.